variant	position	start	end	class	abundance_class	score	sd	expts	se	lower_ci	upper_ci	score1	score2	score3	score4	score5	score6	score7	score8	median_w_ave	exp1_w_ave	exp2_w_ave	exp3_w_ave	exp4_w_ave	exp5_w_ave	exp6_w_ave	exp7_w_ave	exp8_w_ave	rsid	tpmt_allele	hgvs	snv	xca	yca	zca	abs_tco	kappa	alpha	phi	psi	rsa	hbond_sum	helix	sheet	bfactor	schbond_unique_partners	schbond_partner_seq_dist	saltbridge_unique_partners	saltbridge_partner_seq_dist	crowding	substr_dist	grantham	hydro1	hydro2	hydrodiff	vol1	vol2	voldiff	polarity1	polarity2	polaritydiff	weight1	weight2	weightdiff	AA1_PI	AA2_PI	deltaPI	AA1_psic	AA2_psic	delta_psic	evolutionary_coupling_avg	single_WTNorm	single_StErr	published_western	catalytic_efficiency	gnomad_allele_freq	rbc_assay	average_dose_intensity
M1A	1	M	A	missense	wt-like	1.18241755010817	0.301024033420065	6	0.122892547032278	0.941552583956508	1.42328251625983	1.063162697287	1.02213303636472	1.27594371881049	0.770104024696145	NA	NA	1.64804033150451	1.31512149198614	0.733581941112347	0.699732760563024	0.678324806640812	0.800302718019016	0.648193796317749	NA	NA	0.824741977836777	0.76743112166167	NA	NA	p.Met1Ala	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-1.167	-2.987	1.82	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1D	1	M	D	missense	possibly_wt-like	0.784485620841637	0.376986782316888	6	0.153904209408342	0.482838913332176	1.0861323283511	0.882382403649576	1.10705729969264	0.858866817135297	0.209796604481745	NA	NA	1.18355130981365	0.46525929027691	0.668366916029241	0.661226780404247	0.696686431893242	0.675507051654234	0.462617808939488	NA	NA	0.7291942290636	0.576295856993874	NA	NA	p.Met1Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-1.167	-3.828	2.661	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1E	1	M	E	missense	wt-like	1.13103816491359	0.0763423790534935	6	0.0311666457385329	1.06995266174714	1.19212366808003	1.02900694842708	1.10482655850024	1.07920879098903	1.13742324318162	NA	NA	1.20709478887303	1.22866865951053	0.737736959093136	0.692457628072389	0.69620411939261	0.741436676010709	0.76985134393218	NA	NA	0.734037242175564	0.747987751920935	NA	NA	p.Met1Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-1.167	-3.574	2.407	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1G	1	M	G	missense	wt-like	1.02827455371144	0.102411732273866	6	0.0418094146242487	0.946329606833209	1.11021950058967	0.934928333803872	1.05509210526648	1.1583435194677	1.11040945893935	NA	NA	0.889355919361755	1.02151798542947	0.69342510227347	0.672418998887993	0.685450945251004	0.765114974025836	0.760904273979648	NA	NA	0.668676744377314	0.701399259295937	NA	NA	p.Met1Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-1.167	-3.492	2.325	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1H	1	M	H	missense	possibly_low	0.543960343183958	0.546764986175211	6	0.223215870891528	0.106465275458822	0.981455410909095	0.991434937945222	1.22753895806334	0.209281739355519	0.810327136783071	NA	NA	-0.186879448431367	0.212058735387965	0.590433262475722	0.684454836058778	0.722735984448697	0.48114145069061	0.661515846805857	NA	NA	0.447289667954344	0.519350678145587	NA	NA	p.Met1His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-1.167	-4.589	3.422	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1I	1	M	I	missense	wt-like	1.39606491710642	0.115453676169202	3	0.0666572110152204	1.2654191842067	1.52671065000614	NA	NA	1.39958568087182	1.50971794219129	NA	NA	NA	1.27889112825614	0.837298248061839	NA	NA	0.837298248061839	0.893156789963891	NA	NA	NA	0.759282859335591	NA	NA	p.Met1Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-1.167	-3.019	1.852	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1K	1	M	K	missense	wt-like	1.09849338556752	0.169193988692355	6	0.069073156640416	0.96311248625381	1.23387428488123	0.969958258892478	0.951853524847355	1.20257396654185	1.35324391035414	NA	NA	0.942913994037017	1.17041665873228	0.707383560365034	0.679880329839975	0.663129549092061	0.778349387377573	0.841331984670171	NA	NA	0.679693912114064	0.734886790890092	NA	NA	p.Met1Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-1.167	-3.366	2.199	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1L	1	M	L	missense	wt-like	1.17180319814594	0.0983780203384231	6	0.0401626586223804	1.0930858337227	1.25052056256919	1.17808148220287	1.05552960357578	1.13602555113769	1.20433127366972	NA	NA	1.34262259928714	1.11422867900245	0.741323711724739	0.724210320383323	0.685545537534635	0.758437103066154	0.792011542732713	NA	NA	0.761916000502483	0.722250031242222	NA	NA	p.Met1Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-1.167	-2.367	1.2	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1P	1	M	P	missense	wt-like	1.22504865907714	0.192830899307114	6	0.0787228849907387	1.07075463973621	1.37934267841808	1.1270007227744	0.944703717700422	1.23868051500282	1.16149253635062	NA	NA	1.40955003733912	1.46886442529548	0.7767532505831	0.713330181461807	0.661583676636833	0.789153008381807	0.777823187038642	NA	NA	0.775683314127558	0.802008134487728	NA	NA	p.Met1Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-1.167	-3.789	2.622	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1Q	1	M	Q	missense	wt-like	1.22768351931176	0.213287787251539	6	0.087074374522261	1.05702088127178	1.39834615735174	1.08844879232628	0.992263575807316	1.35670047580429	1.04797812685839	NA	NA	1.35895556482079	1.52175458025349	0.752751274710361	0.705118667700826	0.671866677717991	0.824466351301084	0.740226775027677	NA	NA	0.765275774393044	0.813903208472533	NA	NA	p.Met1Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-1.167	-3.583	2.416	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1R	1	M	R	missense	wt-like	1.01824316970585	0.0928461854674899	6	0.0379042964931935	0.943952113719865	1.09253422569184	1.12544129103352	0.989050741957403	0.951543105921766	1.09524915101193	NA	NA	1.0648622112549	0.883312517055599	0.704008233444393	0.712998024419326	0.671172025226009	0.703237187676798	0.755883121285446	NA	NA	0.704779279211989	0.670316645287397	NA	NA	p.Met1Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-1.167	-3.617	2.45	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1S	1	M	S	missense	wt-like	0.912125954495816	0.146785932180735	6	0.0599251058769296	0.794674905207285	1.02957700378435	1.06619838301484	1.09327609242238	0.771504997703253	0.778585169552796	NA	NA	0.805093068845217	0.95809801543641	0.669239731397591	0.700379357888722	0.69370677268271	0.649367084595229	0.651002784337698	NA	NA	0.651343448441152	0.68713601435403	NA	NA	p.Met1Ser	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-1.167	-3.295	2.128	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1T	1	M	T	missense	wt-like	1.00651421459196	0.233215936691665	6	0.0952100074633009	0.819906028996097	1.19312240018782	0.651565766111975	0.789203315402543	1.19962621489844	1.04491985749322	NA	NA	1.20783862074839	1.14593151289717	0.731785148793327	0.612063120546695	0.627962659489228	0.777467375860896	0.739213864370714	NA	NA	0.73419025216684	0.729380045419814	NA	NA	p.Met1Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-1.167	-3.33	2.163	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1V	1	M	V	missense	wt-like	0.920898026621234	0.0457851127623113	6	0.0186916940139088	0.88426297954393	0.957533073698538	0.847696837800717	0.971744275873515	0.902645530162168	0.938882004759518	NA	NA	0.960715370148059	0.903704140983425	0.679129248572542	0.653838797546719	0.667430163569239	0.688606299401681	0.704093716911312	NA	NA	0.683355745511725	0.674902751633358	NA	NA	p.Met1Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-1.167	-2.763	1.596	0.001946481	NA	NA	NA	NA	NA	NA	NA
M1W	1	M	W	missense	wt-like	0.997387103515708	0.17110844901459	6	0.0698547317941294	0.86047434504951	1.13429986198191	0.814479364534461	0.764578464232671	1.02069743905957	1.09092548672546	NA	NA	1.19571706445483	1.09792480208726	0.721256233454407	0.646763516603319	0.62263847684272	0.723929201670573	0.754451106930279	NA	NA	0.731696786527413	0.718583265238241	NA	NA	p.Met1Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-1.167	-4.781	3.614	0.001946481	NA	NA	NA	NA	NA	NA	NA
D2A	2	D	A	missense	wt-like	0.80539798045034	0.0923377757454547	6	0.0376967390933174	0.731513729492835	0.879282231407845	0.790886296641357	0.776338203775819	0.75550787888411	0.706642983443543	NA	NA	0.975198491946693	0.827814028010518	0.643159364402783	0.641738222164985	0.62518107093887	0.644580506640581	0.627175253700559	NA	NA	0.686334997159116	0.657834953113112	NA	NA	p.Asp2Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.604	-2.334	0.73	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2C	2	D	C	missense	wt-like	1.2256005198664	0.187973261504105	6	0.0767397626619676	1.0751933488668	1.37600769086601	1.00157004635096	1.23753961304749	1.1639898460671	1.13480658787722	NA	NA	1.56255705346618	1.25313997238948	0.760147912997433	0.686613601681546	0.724898243759548	0.766804439655928	0.768984697562305	NA	NA	0.807157633766424	0.753491386338937	NA	NA	p.Asp2Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.604	-5.076	3.472	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2E	2	D	E	missense	wt-like	1.17685865494205	0.282052655358372	6	0.115147514370848	0.951173673865879	1.40254363601822	0.691247514978408	1.06749971074709	1.31777540332697	1.38854742230205	NA	NA	1.46529970248936	1.13078217580841	0.75656212013723	0.620515284240936	0.688133615587928	0.812819385624984	0.853024644540973	NA	NA	0.787151303146058	0.725972937128402	NA	NA	p.Asp2Glu	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.604	-2.166	0.562	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2F	2	D	F	missense	possibly_wt-like	0.725402507382429	0.381881234616263	5	0.170782479986702	0.39067499741806	1.0601300173468	NA	1.38620007280058	0.577018915331193	0.615561686432917	NA	NA	0.649743195501723	0.398488666845728	0.597008775416242	NA	0.757040384825877	0.591173930884697	0.597008775416242	NA	NA	0.619387191184231	0.561279045143806	NA	NA	p.Asp2Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.604	-4.367	2.763	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2G	2	D	G	missense	wt-like	0.937068461289165	0.174447804358432	8	0.0616766127124756	0.816184521684287	1.05795240089404	0.987712882625347	0.952033991818646	0.787266597827993	0.707420415908068	1.29540564073145	0.934464018513795	0.862424828637114	0.969819314250902	0.663152725265459	0.683662042854313	0.66316856817527	0.654083191823037	0.627432742343435	0.695393734577644	0.659552680078801	0.663136882355649	0.689772151773311	NA	NA	p.Asp2Gly	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.604	-2.48	0.876	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2H	2	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp2His	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.604	-4.492	2.888	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2I	2	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp2Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.604	-4.05	2.446	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2K	2	D	K	missense	wt-like	1.08704347461753	0.301038817409488	6	0.122898582570687	0.84616667902796	1.3279202702071	0.927636418542327	0.661354899812037	1.14685713278589	1.03930618560275	NA	NA	1.56908880052027	1.17801741044189	0.736975402839855	0.670865829907398	0.600320327319383	0.761678074800964	0.737354594501518	NA	NA	0.808501247280264	0.736596211178192	NA	NA	p.Asp2Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.604	-3.44	1.836	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2L	2	D	L	missense	wt-like	0.851433208204705	0.124751965743168	6	0.0509297767466548	0.751612680040596	0.951253736368814	0.685090171787209	0.731592789536581	0.988444469941001	0.977145214463715	NA	NA	0.884759001824021	0.841567601675702	0.66432964363086	0.619203777715637	0.615506585746656	0.714278629420642	0.716766640140493	NA	NA	0.667731135113122	0.660928152148598	NA	NA	p.Asp2Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.604	-3.687	2.083	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2M	2	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp2Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.604	-4.846	3.242	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2N	2	D	N	missense	wt-like	1.11368973507076	0.208471335924881	8	0.0737057476577512	0.969229124207975	1.25815034593355	0.890641139637972	0.977960537011884	1.06071626578741	1.29065584136549	1.52626413373453	1.04386503347933	1.16218797161174	0.957226957937768	0.705869897112366	0.662985881010332	0.668774192389992	0.735903435027969	0.820602573847406	0.729148646684842	0.680572085550597	0.724799681988962	0.68694011223577	NA	NA	p.Asp2Asn	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.604	-2.256	0.652	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2P	2	D	P	missense	wt-like	1.11629595084935	0.0958250534600152	6	0.0391204142586595	1.0396213478421	1.19297055385661	1.08764192816338	1.0897633931909	1.13135017450981	1.28954186967046	NA	NA	1.1011531098675	0.998325229694082	0.708595653919234	0.704946806626687	0.692947285765952	0.757038160234653	0.820233622108134	NA	NA	0.712244501211782	0.696183174268337	NA	NA	p.Asp2Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.604	-2.772	1.168	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2Q	2	D	Q	missense	possibly_wt-like	0.839401587200027	0.176230854919698	6	0.0719459452479519	0.698390125680351	0.980413048719703	0.807287820319145	1.04031720663042	0.831455122668451	0.97042758186582	NA	NA	0.85786871595633	0.529053075759993	0.664752364135544	0.645231726532099	0.68225643827188	0.667305061413495	0.714541734209885	NA	NA	0.662199666857592	0.590643173591726	NA	NA	p.Asp2Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.604	-3.761	2.157	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2R	2	D	R	missense	wt-like	0.933711520653533	0.0817789183125847	6	0.0333861035970966	0.868275960019101	0.999147081287966	1.00924404737749	1.04483557133228	0.902864222362472	0.936155208695766	NA	NA	0.885453402272361	0.823716671880836	0.685740758179816	0.688248154460061	0.68323336189957	0.68867173538904	0.703190591495417	NA	NA	0.667873976809024	0.656913451666513	NA	NA	p.Asp2Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.604	-3.835	2.231	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2S	2	D	S	missense	possibly_wt-like	0.864520466507365	0.19306238704944	6	0.0788173894658066	0.710041221798917	1.01899971121581	0.910857539011916	1.00530613737332	1.0057396265095	0.993918147766183	NA	NA	0.742768185179594	0.528533163203675	0.670989291120803	0.667291949207877	0.674686633033729	0.719453599744292	0.722321900603837	NA	NA	0.638522903608634	0.590526244489742	NA	NA	p.Asp2Ser	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.604	-2.581	0.977	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2T	2	D	T	missense	wt-like	0.995155179028136	0.0860932259812064	6	0.0351474123273465	0.926267516716758	1.06404284133951	0.996369948275199	1.06711129372727	1.04874651465937	1.07847389352392	NA	NA	0.890216745887837	0.890012678095227	0.686777811222515	0.685505987188284	0.688049635256745	0.73232190590889	0.750327091042851	NA	NA	0.668853820761923	0.671823521403372	NA	NA	p.Asp2Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.604	-3.435	1.831	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2V	2	D	V	missense	possibly_wt-like	0.777788554709688	0.136341890837862	6	0.0556613438531678	0.668694325426379	0.886882783992997	1.02338009039145	0.710779805724826	0.706113832005049	0.64474652236529	NA	NA	0.741049712162651	0.840661365608857	0.633985235873394	0.691259114232653	0.611006573686961	0.62980106675799	0.606674906095986	NA	NA	0.638169404988798	0.66072433831838	NA	NA	p.Asp2Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.604	-3.685	2.081	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2W	2	D	W	missense	possibly_wt-like	0.735752376334467	0.237390895162225	6	0.0969144271216644	0.545803589593673	0.925701163075261	0.911370648138822	1.1171962826738	0.656235990883322	0.452909401205642	NA	NA	0.629644349024599	0.647157586080617	0.616228904456421	0.667401240820709	0.698878599345103	0.614876868379653	0.543137708674287	NA	NA	0.615252756473942	0.617205052438899	NA	NA	p.Asp2Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.604	-5.529	3.925	0.001814418	NA	NA	NA	NA	NA	NA	NA
D2X	2	D	X	nonsense	possibly_low	0.552744448066144	0.458511560510954	6	0.187186560736515	0.185865530632655	0.919623365499633	0.730492181661286	1.18464176167935	0.514064118717357	0.824944736962837	NA	NA	0.0483375530729569	0.013986336303073	0.600605630598989	0.628874349967755	0.713461105709494	0.572336911230223	0.666357252592385	NA	NA	0.495674998753127	0.474803902978584	NA	NA	p.Asp2Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D2Y	2	D	Y	missense	wt-like	0.901381946620025	0.221224069706347	6	0.0903143482670745	0.724369076729351	1.0783948165107	1.00578028098974	1.00757180649451	1.16891204699374	0.911465550570652	NA	NA	0.531422811328072	0.783139183343429	0.68134343692203	0.687510376480408	0.675176497363652	0.76827723602071	0.695013281113116	NA	NA	0.595048087752645	0.647787514549233	NA	NA	p.Asp2Tyr	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.604	-4.374	2.77	0.001814418	NA	NA	NA	NA	NA	NA	NA
G3A	3	G	A	missense	wt-like	0.943546330132181	0.147647842028849	6	0.0602769790989562	0.825405622001354	1.06168703826301	1.09209590356294	0.983233007879273	1.08883123679152	0.697824935770495	NA	NA	0.896790652657909	0.902502244130952	0.672419274999474	0.705895497907757	0.669914162646167	0.74431585615988	0.624254682163155	NA	NA	0.670206106743276	0.674632443255672	NA	NA	p.Gly3Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-2.405	-2.732	0.327	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3C	3	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly3Cys	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-2.405	-3.11	0.705	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3D	3	G	D	missense	wt-like	1.00662850008804	0.123775546454938	6	0.0505311552414588	0.90758925571758	1.1056677444585	0.941204877965903	0.900928597244319	1.06619263313912	1.18443043874203	NA	NA	0.864434414171387	1.08258003926549	0.694444050242108	0.673755895073446	0.652118980380461	0.737542046301261	0.785420309138225	NA	NA	0.663550264297526	0.715132205410771	NA	NA	p.Gly3Asp	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-2.405	-2.364	-0.041	0.00162102	NA	NA	NA	NA	4.06e-06	NA	NA
G3E	3	G	E	missense	wt-like	1.05617047831591	0.0586284976127578	6	0.023934983922873	1.00925877185653	1.10308218477529	1.09246664426709	1.07285749757687	1.01899486649672	1.04315978948895	NA	NA	0.971000262840645	1.13854380922518	0.714697115818919	0.705974465221676	0.689292032159302	0.723419766416162	0.738630923031797	NA	NA	0.685471400128433	0.727718539950112	NA	NA	p.Gly3Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-2.405	-2.876	0.471	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3F	3	G	F	missense	possibly_low	0.633674297905319	0.284415816826394	6	0.116112271000258	0.406098428581658	0.86125016722898	1.14916109600771	0.654604294259889	0.510024122225129	0.657828683699592	NA	NA	0.299079610034032	0.531347981205559	0.595010034082038	0.718050313700027	0.598860766947374	0.571128083667886	0.611007768590874	NA	NA	0.547253912239981	0.591159301216703	NA	NA	p.Gly3Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-2.405	-4.281	1.876	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3G	3	G	G	synonymous	wt-like	0.946950013430011	0.0516716377150139	6	0.0210948577626225	0.905604851956276	0.988295174903746	0.955582082344335	1.0300786597244	0.96098868622391	0.942736239200152	NA	NA	0.873905829255797	0.918408583831474	0.679126273240215	0.676818221920004	0.680042743927639	0.70606344701476	0.70537025428366	NA	NA	0.665498582442306	0.678209802552791	NA	NA	p.Gly3=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3H	3	G	H	missense	wt-like	1.24811996999367	0.146654651388671	6	0.0598715107179987	1.13077396528639	1.36546597470095	1.11651292399887	1.09566972640846	1.30435133436602	1.29609182260626	NA	NA	1.48861166656748	1.18748234601493	0.765335790811355	0.711096293224134	0.694224304522511	0.808802702791243	0.822402991885312	NA	NA	0.791946692451571	0.738724889171138	NA	NA	p.Gly3His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-2.405	-2.802	0.397	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3I	3	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly3Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-2.405	-4.089	1.684	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3K	3	G	K	missense	possibly_low	0.674903817905635	0.352165971546634	5	0.157493410348106	0.36622240582096	0.983585229990311	1.16742940528741	NA	0.89204965445676	0.458874674755016	NA	NA	0.290533093498518	0.565632261530477	0.598869886510023	0.721941441103931	NA	0.685435854421238	0.545113430374498	NA	NA	0.54549585042003	0.598869886510023	NA	NA	p.Gly3Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-2.405	-2.711	0.306	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3L	3	G	L	missense	wt-like	1.05343221220847	0.0396975640010716	6	0.0162064626390173	1.0216681291192	1.08519629529774	1.02589139965268	1.04522133861281	0.999294993553599	1.09318719805026	NA	NA	1.10385233597373	1.05314600740774	0.710656096940918	0.691794020016019	0.683316769325932	0.717525268875386	0.755200194479583	NA	NA	0.712799745718836	0.708512448163001	NA	NA	p.Gly3Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-2.405	-3.651	1.246	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3M	3	G	M	missense	wt-like	1.05262578201169	0.220433069276246	6	0.0899914236937298	0.876245832654497	1.22900573136889	0.774993726229682	0.779434763376677	1.20390335874914	1.18038987625819	NA	NA	1.27540625431126	1.10162671314521	0.73375254388057	0.638353124217466	0.625850583569709	0.778747161470797	0.784082059196406	NA	NA	0.748089257257124	0.719415830504015	NA	NA	p.Gly3Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-2.405	-4.848	2.443	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3N	3	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly3Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-2.405	-2.743	0.338	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3P	3	G	P	missense	wt-like	1.10088846536815	0.270822106512846	6	0.110562662003692	0.884189629806036	1.31758730093026	0.829650678203436	0.717529736698586	1.11648123790664	1.23750186685837	NA	NA	1.32879382030761	1.37537345223424	0.755830250909238	0.649994987751893	0.612465988207184	0.752589151325086	0.802997771650671	NA	NA	0.75907135049339	0.780981876531826	NA	NA	p.Gly3Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-2.405	-3.079	0.674	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3Q	3	G	Q	missense	wt-like	1.26147077872565	0.534377458491125	5	0.238980864565946	0.793076891182151	1.72986466626915	0.790701631483207	0.582421666774657	1.54069534554187	NA	NA	NA	1.73263361730071	1.6609016325278	0.842143245986732	0.641698888713464	0.583254033327539	0.879520376792249	NA	NA	NA	0.842143245986732	0.845197586091286	NA	NA	p.Gly3Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-2.405	-3.956	1.551	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3R	3	G	R	missense	wt-like	0.875317120937725	0.0866833547471087	6	0.0353883313871797	0.805957265945884	0.944676975929566	0.950267493341202	0.96687956502975	0.901071614304252	0.892108955666632	NA	NA	0.790417345493778	0.751157751790736	0.67103228841469	0.675686221000052	0.666378355829327	0.688135360163613	0.68860230192205	NA	NA	0.648324577677009	0.64059484334679	NA	NA	p.Gly3Arg	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-2.405	-2.843	0.438	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3S	3	G	S	missense	wt-like	1.10257432973424	0.123443825236434	6	0.0503957306210943	1.00380051274231	1.20134814672617	0.97455260635382	1.09723326058218	1.26824193580474	1.23781418881858	NA	NA	1.01994598199048	1.01765800485563	0.698035463445553	0.680858920197527	0.694562359012974	0.797998228994237	0.803101213893367	NA	NA	0.695539782928583	0.700531143962523	NA	NA	p.Gly3Ser	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-2.405	-2.487	0.082	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3T	3	G	T	missense	wt-like	1.13427241395413	0.347535989221577	6	0.141880973474376	0.856190815852874	1.41235401205539	0.551141596109485	0.858238657413349	1.37080621163338	1.30972509780943	NA	NA	1.33601966018547	1.3797032605737	0.771256699623501	0.590672895872466	0.642888912947337	0.828686999088783	0.82691838542777	NA	NA	0.760557742423196	0.781955656823806	NA	NA	p.Gly3Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-2.405	-2.532	0.127	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3V	3	G	V	missense	wt-like	1.01596014173147	0.148210342684973	6	0.0605066190302035	0.897369347605981	1.13455093585695	1.01369771370882	1.04117557954354	0.746788272654722	1.03884879153529	NA	NA	1.20270858311755	1.05254190982887	0.698786682817529	0.689196779909979	0.682442028598365	0.641971469636939	0.737203103815107	NA	NA	0.73313497739422	0.708376585725078	NA	NA	p.Gly3Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-2.405	-3.733	1.328	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3W	3	G	W	missense	wt-like	1.05606491453715	0.143840413393437	6	0.058722602867486	0.940970727838429	1.17115910123587	0.872354535265803	1.22542743794186	0.886184866887356	1.13956476231587	NA	NA	1.09892464147171	1.1139332433403	0.716984840639973	0.659090856774237	0.722279448946778	0.683681021991363	0.770560623362527	NA	NA	0.711786093954589	0.722183587325356	NA	NA	p.Gly3Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-2.405	-5.412	3.007	0.00162102	NA	NA	NA	NA	NA	NA	NA
G3X	3	G	X	nonsense	possibly_low	0.582682331663892	0.465394877035564	6	0.189996662940409	0.210295715117895	0.955068948209889	0.833016548897757	1.33904469512144	0.542911279977716	0.15598282475567	NA	NA	0.0690180637327301	0.556120577498045	0.588849554695656	0.650711914069274	0.746844837173753	0.580968414671816	0.444794476699124	NA	NA	0.499929084737394	0.596730694719496	NA	NA	p.Gly3Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G3Y	3	G	Y	missense	possibly_wt-like	0.786866263005503	0.248436717369743	6	0.101423865154651	0.58807914012954	0.985653385881467	0.485866439756215	0.480328217198379	0.907471241900574	0.809168165693311	NA	NA	1.04213423488539	0.996229278599156	0.675591107923253	0.576769367867134	0.561180227934503	0.69005022475372	0.661131991092787	NA	NA	0.700104019141531	0.695711791770735	NA	NA	p.Gly3Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-2.405	-3.216	0.811	0.00162102	NA	NA	NA	NA	NA	NA	NA
T4A	4	T	A	missense	wt-like	1.1146792172103	0.218561870360636	6	0.0892275099353143	0.939796511306892	1.2895619231137	1.07244988879883	1.14963547388785	1.37378913587334	1.24850449617346	NA	NA	0.726366176954618	1.11733013157369	0.714419943393879	0.701710920930451	0.705892334280481	0.829579534774041	0.806641885087762	NA	NA	0.635148927286113	0.722947552507277	NA	NA	p.Thr4Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.987	-2.03	0.043	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4C	4	T	C	missense	possibly_wt-like	0.843129126515326	0.155240552339795	6	0.0633766901033871	0.718913096453331	0.967345156577321	0.893615693450934	1.09973283602478	0.888191926354705	0.711684109737912	NA	NA	0.667816201496385	0.797733992027239	0.657344682948263	0.66361945731336	0.695102796642559	0.684281564295805	0.62884489425113	NA	NA	0.623104900227316	0.651069908583166	NA	NA	p.Thr4Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.987	-4.815	2.828	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4D	4	T	D	missense	wt-like	1.11158001733931	0.208002546169558	2	0.147080010900563	0.823308493128454	1.39985154155018	0.964500006438752	1.25866002823988	NA	NA	NA	NA	NA	NA	0.70409122744192	0.678717728781774	0.729464726102065	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr4Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.987	-3.681	1.694	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4E	4	T	E	missense	wt-like	0.990705512194727	0.0627978975141594	6	0.0256371343048804	0.940457652290345	1.04095337209911	1.05540510177295	0.978128544441945	0.91345419382905	1.07571410266112	NA	NA	0.94686169596933	0.97466943449397	0.691351682356858	0.6980804022615	0.668810517573744	0.691840413732644	0.74941303762174	NA	NA	0.68050597443383	0.690862950981071	NA	NA	p.Thr4Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.987	-3.577	1.59	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4F	4	T	F	missense	wt-like	0.871358770098544	0.0747585967718007	6	0.0305200693295649	0.811540533406931	0.931177006790156	0.865042260265599	0.944513715459921	0.890764632921247	0.950969311980773	NA	NA	0.75614857807443	0.820714121889293	0.659537973555274	0.657533351194352	0.661542595916195	0.6850513566987	0.708097079871364	NA	NA	0.641275318324805	0.656238173737741	NA	NA	p.Thr4Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.987	-3.03	1.043	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4G	4	T	G	missense	wt-like	1.06533837466435	0.0664476025646863	6	0.0271271201524554	1.01217019616125	1.11850655316745	1.02071932296515	0.968734187428997	1.16471722955702	1.06902935469019	NA	NA	1.09264822354031	1.07618192980442	0.712094132038984	0.690692374043981	0.666779347020127	0.767022083709012	0.74719902320693	NA	NA	0.710495002936933	0.713693261141035	NA	NA	p.Thr4Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.987	-3.34	1.353	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4H	4	T	H	missense	wt-like	1.28411940165126	0.160444920854535	6	0.0655013646524736	1.15573908599418	1.41249971730833	1.11628251923264	1.24327459007606	1.40418541840954	1.29630931958811	NA	NA	1.12060170034449	1.52406286225671	0.770280278898174	0.711047217292358	0.726138213291261	0.838674558542754	0.822475027727961	NA	NA	0.716245174963173	0.814422344505087	NA	NA	p.Thr4His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.987	-4.737	2.75	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4I	4	T	I	missense	possibly_low	0.621900555135473	0.135602093903848	6	0.0553593230195661	0.513398275808604	0.730402834462341	0.619440212189319	0.845569144391138	0.65411566268326	0.65128260397677	NA	NA	0.483271155277384	0.477724552294965	0.607030049358548	0.605220417080263	0.640149615117383	0.614242434371019	0.608839681636833	NA	NA	0.585143047761397	0.579099312836695	NA	NA	p.Thr4Ile	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.987	-2.894	0.907	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4K	4	T	K	missense	wt-like	0.915453016184398	0.169608679020671	6	0.0692424532580232	0.779740301597475	1.05116573077132	0.721139906505435	0.814201429897524	1.13754703853032	1.11228583023182	NA	NA	0.845168708675266	0.862375183266022	0.662597509451042	0.626882326864214	0.633367546059769	0.758892354920828	0.761525735418003	NA	NA	0.659587210914734	0.665607807987349	NA	NA	p.Thr4Lys	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.987	-3.538	1.551	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4L	4	T	L	missense	wt-like	0.843625994549899	0.0864515258427295	6	0.0352936876332868	0.77445163790705	0.912800351192748	0.906683456502376	0.972809714837102	0.847736329942705	0.827232781361508	NA	NA	0.743004320477459	0.764289364178245	0.666758968262901	0.666402874768072	0.667660524012911	0.672176642896077	0.667115061757729	NA	NA	0.638571477837654	0.643548162372102	NA	NA	p.Thr4Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.987	-2.655	0.668	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4M	4	T	M	missense	wt-like	1.13901664744283	0.0879728033577484	6	0.0359147465781144	1.06862503763584	1.20940825724982	1.23101101567683	1.24072074529544	1.06721709455796	1.14640230140328	NA	NA	1.01814976953563	1.13059895818783	0.730707988558568	0.735484245902271	0.725586041992071	0.737848580527721	0.772825242786803	NA	NA	0.695170292911888	0.725931731214864	NA	NA	p.Thr4Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.987	-4.531	2.544	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4N	4	T	N	missense	wt-like	1.16369435424655	0.164309754678372	6	0.0670791764539821	1.03222158428414	1.29516712420897	1.06993777955741	0.970284456102798	1.2104990120543	1.12089652433312	NA	NA	1.15581051739318	1.45473783603851	0.7439327189719	0.701175844752288	0.667114533353378	0.780720679893954	0.764377630649462	NA	NA	0.723487807294338	0.798831043694594	NA	NA	p.Thr4Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.987	-3.735	1.748	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4P	4	T	P	missense	wt-like	1.09656209807149	0.193042797775698	6	0.0788093921782898	0.942098527758552	1.25102566838443	1.05768898791192	0.892410483396824	1.17177193910649	1.28193251908818	NA	NA	1.31468276134109	0.860885897584452	0.727367750629079	0.698566867199589	0.650277263912209	0.769132958647661	0.817713375727898	NA	NA	0.756168634058569	0.665272865437439	NA	NA	p.Thr4Pro	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.987	-2.607	0.62	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4Q	4	T	Q	missense	possibly_wt-like	0.808516247131712	0.286426828895662	6	0.116933263239639	0.579331262587277	1.03770123167615	1.07132356391088	1.13190589925659	0.594504518784917	0.565939224415055	NA	NA	0.992216979025472	0.495207297397356	0.643120836041903	0.70147101511486	0.70205899157597	0.596405885773671	0.580573623831811	NA	NA	0.689835786310134	0.583031208037523	NA	NA	p.Thr4Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.987	-4.005	2.018	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4R	4	T	R	missense	wt-like	0.997070491140481	0.0616691933340813	6	0.0251763427529241	0.947725766082313	1.04641521619865	0.907836165927689	1.06289158161087	0.955281211591758	1.03292027107309	NA	NA	1.0521072607701	0.971386455869381	0.696140062705883	0.666648400457664	0.687137283833038	0.704355684975869	0.735239554879696	NA	NA	0.702155521173317	0.690124604238449	NA	NA	p.Thr4Arg	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.987	-2.964	0.977	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4S	4	T	S	missense	wt-like	1.0399307078578	0.0665495465569371	6	0.0271687386130148	0.986680958670907	1.09318045704469	0.937683441285361	1.03485665372215	1.008406069227	1.11348669444076	NA	NA	1.11212493514841	1.03302645332311	0.709244496037198	0.673005833392368	0.681075802464824	0.720251439409874	0.761923466294377	NA	NA	0.714501461347692	0.703987530726703	NA	NA	p.Thr4Ser	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.987	-1.854	-0.133	0.001454016	NA	NA	NA	NA	4.06e-06	NA	NA
T4T	4	T	T	synonymous	possibly_wt-like	0.848100285044173	0.229472095782116	8	0.0811306375103117	0.689087157481188	1.00711341260716	1.07493384804978	1.01386360733174	0.929676418540262	1.04603771058713	0.50414218522339	0.525737564105951	0.741292993890298	0.949117952624841	0.680826621858904	0.702240001195273	0.676536858756366	0.696694346747452	0.739584101644328	0.579699362467383	0.581023362275352	0.638219449274689	0.685116384961441	NA	NA	p.Thr4=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4V	4	T	V	missense	wt-like	0.998336292447527	0.02231801389174	6	0.00911129101785162	0.980478490199875	1.01619409469518	0.980994764763042	1.02061374140075	0.962316074313266	1.00387240602801	NA	NA	1.00669473558357	1.01552603259652	0.696432797276101	0.682231092013902	0.677996317188173	0.706460621445832	0.725618789488247	NA	NA	0.692813934300321	0.700051660251881	NA	NA	p.Thr4Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.987	-3.323	1.336	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4W	4	T	W	missense	wt-like	1.07859319912397	0.0910010843084383	6	0.0371510370992778	1.00577850442107	1.15140789382686	0.940978046126561	1.05624879171552	1.19720397702782	1.1386704748525	NA	NA	1.02386591730342	1.11459198771799	0.709338936711453	0.673707580170702	0.685701034474971	0.776742605949297	0.770264431891509	NA	NA	0.696346133513844	0.722331739909063	NA	NA	p.Thr4Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.987	-5.331	3.344	0.001454016	NA	NA	NA	NA	NA	NA	NA
T4X	4	T	X	nonsense	wt-like	0.85940686901108	0.0820672296858169	6	0.0335038062223399	0.793740615470285	0.925073122551875	0.851872467732369	0.844098364123259	0.919615582246774	0.953847542148732	NA	NA	0.71555034349728	0.871456914318067	0.661189252151473	0.65472820158553	0.639831615113036	0.693683993586225	0.709050360849004	NA	NA	0.632924055459881	0.667650302717416	NA	NA	p.Thr4Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T4Y	4	T	Y	missense	wt-like	1.23037567984606	0.240283684715765	6	0.098095403511569	1.03811222191446	1.42263913777766	1.0164331596787	0.909319225228087	1.28125105571282	1.19337547110953	NA	NA	1.48421947579608	1.49765569155112	0.789713067510134	0.68977942653657	0.653933132904523	0.801890752845899	0.788382938498183	NA	NA	0.791043196522084	0.808483332802026	NA	NA	p.Thr4Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.987	-4.166	2.179	0.001454016	NA	NA	NA	NA	NA	NA	NA
R5A	5	R	A	missense	wt-like	0.98666517547761	0.0672360749083403	6	0.0274490126388302	0.932866099294318	1.0404642516609	0.911894833763199	1.01941313395786	0.938351583647045	1.07178411602001	NA	NA	1.04560916176784	0.932938223709701	0.690383813163269	0.667512891713877	0.677736731728403	0.699290086300463	0.748111410827241	NA	NA	0.700818829234483	0.681477540026075	NA	NA	p.Arg5Ala	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.08	-2.175	0.095	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5C	5	R	C	missense	wt-like	1.14903164283821	0.132530529860953	6	0.0541053622500041	1.04298708145771	1.25507620421871	1.32966648793796	1.17833955633493	1.16837276271008	1.22655843133372	NA	NA	1.0166373913685	0.974615227344051	0.734298117436606	0.756497740133346	0.712098494739866	0.768115874072184	0.799373263426205	NA	NA	0.69485918904847	0.690850759712974	NA	NA	p.Arg5Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.08	-4.945	2.865	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5D	5	R	D	missense	wt-like	0.812159341148166	0.0569844559875481	2	0.0402940952510216	0.733184365666537	0.891134316629795	0.852453436399188	0.771865245897145	NA	NA	NA	NA	NA	NA	0.639532955998828	0.654851947196887	0.624213964800769	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg5Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.08	-3.672	1.592	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5E	5	R	E	missense	wt-like	1.29166007813424	0.20060995177751	6	0.0818986698632066	1.13114163482062	1.45217852144786	1.27891025879245	0.893794235969363	1.37893830479428	1.41076116590029	NA	NA	1.40096075874646	1.38659574460258	0.778711121299821	0.745686725762878	0.650576447504546	0.831120243367906	0.86038192244394	NA	NA	0.773916455935459	0.783505786664183	NA	NA	p.Arg5Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.08	-3.444	1.364	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5F	5	R	F	missense	possibly_wt-like	0.752336406406458	0.0973911892992587	6	0.0397597865376648	0.674408656759634	0.830264156053281	0.616374146440242	0.830084117373916	0.842485052077922	0.813824910754378	NA	NA	0.763171914651048	0.64807829714124	0.639760812161158	0.604567348847415	0.636801570024356	0.670605381774279	0.662674323090363	NA	NA	0.64272005429796	0.617412121716602	NA	NA	p.Arg5Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.08	-4.288	2.208	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5G	5	R	G	missense	wt-like	1.12473837962059	0.132615048278416	6	0.0541398667494458	1.01862619066387	1.2308505685773	0.932280298668915	1.00284433231963	1.23892872330945	1.16472660919279	NA	NA	1.27028203797319	1.13936827625954	0.737469571879048	0.671854970661715	0.674154361806767	0.789227276031007	0.77889432448799	NA	NA	0.747035179953968	0.727903963804127	NA	NA	p.Arg5Gly	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.08	-2.616	0.536	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5H	5	R	H	missense	wt-like	1.14757646565158	0.110258336280155	6	0.0450127772957632	1.05935304330776	1.2357998879954	0.96575067241777	1.10630202552744	1.22459698534528	1.1230118872904	NA	NA	1.28252213904444	1.18327508428413	0.743665850324098	0.678984119096804	0.696523132729483	0.784939005013793	0.765078247052707	NA	NA	0.749553030855711	0.737778669792484	NA	NA	p.Arg5His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.08	-4.651	2.571	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5I	5	R	I	missense	wt-like	0.990644932410229	0.18783233690224	6	0.0766822304341717	0.840350522505052	1.14093934231541	0.953948365936284	1.18595620031331	0.964535850550833	1.08639360224383	NA	NA	1.10125352399003	0.651782051427098	0.709694984352816	0.676470242334798	0.713745302812515	0.707124811799302	0.752950129240137	NA	NA	0.71226515690633	0.618245101527056	NA	NA	p.Arg5Ile	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.08	-2.973	0.893	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5K	5	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg5Lys	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.08	-2.141	0.061	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5L	5	R	L	missense	wt-like	0.994251800048145	0.0557454172237634	6	0.0227579712827962	0.949646995972667	1.03885660412362	0.913906036744727	0.968408309695428	0.980571473999489	1.0547210421141	NA	NA	0.986491660405104	1.06141227733002	0.699514801848783	0.667941275474871	0.666708888418693	0.711922910916784	0.74246005467246	NA	NA	0.688658059217266	0.710371544480301	NA	NA	p.Arg5Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.08	-3.376	1.296	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5M	5	R	M	missense	wt-like	0.970000677288582	0.159926203814917	6	0.0652895993078152	0.842035414080213	1.09796594049695	1.05589983921755	1.20940798506532	0.989150873998039	0.939724196684121	NA	NA	0.733697459187916	0.892123709578542	0.701279217433375	0.698185780728602	0.718815854693011	0.714489996112652	0.704372654138148	NA	NA	0.636657009243492	0.672298295502601	NA	NA	p.Arg5Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.08	-4.62	2.54	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5N	5	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg5Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.08	-3.665	1.585	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5P	5	R	P	missense	possibly_wt-like	0.746260433650975	0.246619545995344	6	0.100682008047573	0.54892732398656	0.94359354331539	0.990947027027089	1.12241312724915	0.602211286810612	0.641395080866513	NA	NA	0.530026751491487	0.590569328460996	0.60502158269767	0.684350911633417	0.700006542542243	0.598711866391208	0.605564895693057	NA	NA	0.594760911160069	0.604478269702283	NA	NA	p.Arg5Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.08	-2.866	0.786	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5Q	5	R	Q	missense	possibly_wt-like	0.825147030021879	0.294421291379148	6	0.1201969888817	0.589565260763586	1.06072879928017	0.767254294321228	1.22400885676699	0.748189938922675	0.537735868186394	NA	NA	1.13865435457111	0.535038867362878	0.639547751977513	0.636704634741589	0.7219727350007	0.642390869213438	0.571232563030739	NA	NA	0.719958697544299	0.591989386966038	NA	NA	p.Arg5Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.08	-3.846	1.766	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5R	5	R	R	synonymous	wt-like	1.07439814502674	0.0347886412218512	6	0.0142024033063814	1.04656194605231	1.10223434400116	1.06046810039299	1.06143987946034	1.01714138190961	1.10294903681785	NA	NA	1.10721709529737	1.09717337628224	0.715953081125256	0.699158814739346	0.686823408742204	0.722865176019963	0.758433353282351	NA	NA	0.713491893785903	0.718414268464608	NA	NA	p.Arg5=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5S	5	R	S	missense	wt-like	1.03298197702621	0.133282328239847	6	0.054412282652961	0.926335862709788	1.13962809134262	1.136195112479	1.01591682748545	1.1570866234661	1.11031568065277	NA	NA	0.802179300530745	0.976198317543171	0.703247687097955	0.715288575158451	0.67698078911909	0.764738891885014	0.760873214247973	NA	NA	0.650744071513188	0.691206799037459	NA	NA	p.Arg5Ser	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.08	-2.296	0.216	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5T	5	R	T	missense	wt-like	1.02591889158232	0.249184922861262	6	0.10172931876748	0.826533090626268	1.22530469253838	0.818919386867695	0.618558539179203	1.17708751801494	1.24593503038399	NA	NA	1.16810084984617	1.12691202520194	0.725559262792912	0.647709235898426	0.591067250456371	0.770723459606429	0.805790868067974	NA	NA	0.726015991046201	0.725102534539623	NA	NA	p.Arg5Thr	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.08	-2.31	0.23	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5V	5	R	V	missense	wt-like	1.11743869686257	0.14066949884031	6	0.0574280824219649	1.00488172361432	1.22999567011082	1.14214314979604	1.01169174153218	1.21097510618472	1.34053494629593	NA	NA	1.02055358875604	0.978733648610526	0.70611013525677	0.716555499790032	0.676067275808604	0.780863134400593	0.837122726558339	NA	NA	0.695664770723509	0.691776998739957	NA	NA	p.Arg5Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.08	-3.453	1.373	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5W	5	R	W	missense	wt-like	1.19677897710068	0.151909888575698	6	0.0620169523155848	1.07522798413119	1.31832997007016	0.945382626168849	1.10093911387512	1.27704010627217	1.19515428937968	NA	NA	1.34657497869803	1.31558274821021	0.765131941935602	0.674645750301437	0.695363608111159	0.800630773596595	0.788972089997771	NA	NA	0.762729025003327	0.767534858867876	NA	NA	p.Arg5Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.08	-5.426	3.346	0.001436606	NA	NA	NA	NA	NA	NA	NA
R5X	5	R	X	nonsense	possibly_wt-like	0.764578191941753	0.102716285653634	6	0.0419337480208938	0.682389556084024	0.846766827799483	0.740707824306595	0.947026210577824	0.778492865191365	0.741396458078219	NA	NA	0.630684962872617	0.749160830623898	0.639415735954749	0.631050269284483	0.662085826931639	0.651457959386293	0.638685739083186	NA	NA	0.615466816022988	0.640145732826312	NA	NA	p.Arg5Ter	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R5Y	5	R	Y	missense	wt-like	0.988162786507119	0.131109975590578	6	0.0535254233976123	0.883254884390541	1.0930706886237	0.736053234803868	0.952209413922534	1.0445640126029	1.06960066761041	NA	NA	1.06280937659641	1.06374001350658	0.707626028245488	0.630058847446222	0.663206496498771	0.73107043854373	0.747388244258529	NA	NA	0.704357000705797	0.710895055785179	NA	NA	p.Arg5Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.08	-4.314	2.234	0.001436606	NA	NA	NA	NA	NA	NA	NA
T6A	6	T	A	missense	wt-like	1.41092172506618	0.2048214697938	6	0.0836180148936146	1.24703342741596	1.5748100227164	1.35042509162541	1.15309962828306	1.3204415893306	1.3998570018155	NA	NA	1.76778087648337	1.47392616285914	0.808381837610717	0.760919297182677	0.706641325232287	0.813617148477923	0.856770421072431	NA	NA	0.849373215552484	0.803146526743512	NA	NA	p.Thr6Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.797	-2.222	0.425	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6C	6	T	C	missense	possibly_wt-like	0.814056834122384	0.19812033252437	6	0.0808822870592062	0.65553046449911	0.972583203745658	0.897652993058065	1.07042524513826	0.684774386362142	0.651004818517997	NA	NA	0.591356102329994	0.989127459327849	0.643947690815114	0.664479397163214	0.68876615055554	0.623415984467014	0.608747678017157	NA	NA	0.6073766698383	0.694114582125084	NA	NA	p.Thr6Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.797	-4.957	3.16	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6D	6	T	D	missense	wt-like	0.951956455498335	0.143887009719624	6	0.0587416257379938	0.836824984658536	1.06708792633813	0.766113018008219	0.919990981711409	1.06505002375015	0.850525186613882	NA	NA	0.946330376060817	1.16372914684553	0.677613137905097	0.636461544290854	0.656240492258061	0.73720016042957	0.674829596577685	NA	NA	0.680396679232509	0.733382759587286	NA	NA	p.Thr6Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.797	-2.522	0.725	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6E	6	T	E	missense	wt-like	1.03190056529721	0.338275260009406	6	0.138100296605059	0.761228957697001	1.30257217289743	0.868437416178504	0.438674201857668	1.16275923134377	1.06604313054447	NA	NA	1.33712079089743	1.31836862096145	0.753497112401944	0.658256515227267	0.552174139568546	0.766436221267858	0.746209974205644	NA	NA	0.760784250598244	0.768161405765208	NA	NA	p.Thr6Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.797	-2.757	0.96	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6F	6	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr6Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.797	-4.306	2.509	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6G	6	T	G	missense	possibly_wt-like	0.821646093537725	0.181006606227254	6	0.073895637554942	0.676813305315413	0.966478881760036	1.01992592150061	1.02399972972669	0.761954540546763	0.781244776365116	NA	NA	0.542539852435417	0.800211740651754	0.651755407161265	0.690523380508031	0.678728407715823	0.646509444528984	0.651883656413327	NA	NA	0.597334919520938	0.651627157909203	NA	NA	p.Thr6Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.797	-2.393	0.596	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6H	6	T	H	missense	possibly_low	0.539492078614319	0.512903709125339	6	0.209392062422994	0.129091177616687	0.94989297961195	0.91663492273813	1.03996524664768	-0.0467651267867333	0.273260855147612	NA	NA	0.0230688400881954	1.03078773385103	0.579499810551347	0.66852252483454	0.682180340381197	0.404528386882725	0.48363741452678	NA	NA	0.490477096268154	0.703484039410167	NA	NA	p.Thr6His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.797	-3.199	1.402	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6I	6	T	I	missense	wt-like	1.01574537733199	0.146768567508788	6	0.0599180167792929	0.898308222419513	1.13318253224447	0.744236153347081	0.957932940468914	1.08894094950373	1.13461145421301	NA	NA	1.05489120068773	1.11385956577149	0.712447604436267	0.63180179902975	0.664443990301469	0.744348683849387	0.768920068537062	NA	NA	0.702728191741248	0.722167017131286	NA	NA	p.Thr6Ile	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.797	-3.956	2.159	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6K	6	T	K	missense	wt-like	1.39086476856351	0.335511178421981	6	0.13697186502229	1.12240484622454	1.65932469090248	0.969700166105932	1.11125312823971	1.36674187894002	1.34224348523445	NA	NA	1.82843640569482	1.72681354716613	0.832579745520545	0.679825356393933	0.697593619408161	0.827470889769955	0.837688601271135	NA	NA	0.861850365702777	0.860021273065269	NA	NA	p.Thr6Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.797	-3.544	1.747	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6L	6	T	L	missense	wt-like	0.861188949678342	0.121513644190705	6	0.0496077375088895	0.763959570806402	0.958418328550282	0.915254322424073	1.00623357672172	0.868890715280886	0.8248843358209	NA	NA	0.906229529028319	0.645641218794153	0.670188095087728	0.668228458665985	0.674887156336403	0.678506352367429	0.666337247500271	NA	NA	0.672147731509472	0.616864019196041	NA	NA	p.Thr6Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.797	-3.544	1.747	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6M	6	T	M	missense	possibly_wt-like	0.83338071865479	0.271973921595633	3	0.157024216845797	0.52561890893642	1.14114252837316	0.52842563013066	1.05083217703273	0.920884348800974	NA	NA	NA	NA	NA	0.6845298986294	0.585834423062911	0.6845298986294	0.694063627574481	NA	NA	NA	NA	NA	NA	NA	p.Thr6Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.797	-4.774	2.977	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6N	6	T	N	missense	wt-like	1.1238049720408	0.176566181408792	6	0.0720828417138718	0.982525198378309	1.26508474570329	1.18388841567214	0.896791465865024	1.29125394785318	1.2884530029852	NA	NA	0.914839664655802	1.16760333521345	0.729850630171743	0.725447190068908	0.651224483884055	0.804883768247177	0.819872985245313	NA	NA	0.673918880099471	0.734254070274577	NA	NA	p.Thr6Asn	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.797	-2.586	0.789	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6P	6	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr6Pro	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.797	-2.897	1.1	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6Q	6	T	Q	missense	possibly_low	0.526234817326991	0.354588964967955	6	0.144760338765518	0.242509766956758	0.809959867697224	0.968044631589682	0.962215446220478	0.484077613055565	0.185757431705771	NA	NA	0.318026359411623	0.239287421978827	0.557257926790434	0.679472729578519	0.665369918448151	0.563364498850194	0.454655941823841	NA	NA	0.551151354730674	0.525474449984874	NA	NA	p.Thr6Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.797	-3.928	2.131	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6R	6	T	R	missense	possibly_low	0.715214430115694	0.212005806826337	6	0.0865510082052641	0.545577571207746	0.884851289023643	0.889336292253605	0.954194469408588	0.699421072786887	0.776183223138087	NA	NA	0.367065791663598	0.605085731443401	0.639002871586172	0.662707950122613	0.663635688858079	0.62779849278879	0.650207250383555	NA	NA	0.561239014791474	0.607743030178142	NA	NA	p.Thr6Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.797	-3.861	2.064	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6S	6	T	S	missense	wt-like	1.11404705161546	0.0750003612088135	6	0.0306187692476703	1.05403536663908	1.17405873659183	1.13500196252064	1.09416908165787	1.21368038322045	1.08346677954642	NA	NA	1.16255826400666	0.995405838740703	0.719955144349343	0.715034435685069	0.69389984746551	0.781672593876815	0.75198075422857	NA	NA	0.724875853013617	0.695526598930099	NA	NA	p.Thr6Ser	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.797	-2.295	0.498	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6T	6	T	T	synonymous	wt-like	0.906000433291862	0.126111195213691	6	0.0514846798543437	0.805092315021773	1.00690855156195	1.06279756318562	0.963412646939954	0.964499096649282	0.881395094064387	NA	NA	0.873692443591107	0.69020575532082	0.675341298401968	0.699654987448599	0.665628767334224	0.707113814480541	0.685053829469713	NA	NA	0.665454687928271	0.626886649296181	NA	NA	p.Thr6=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6V	6	T	V	missense	wt-like	1.0793448728434	0.130219394428839	6	0.0531618451608128	0.975149570976511	1.18354017471029	0.908737365067238	0.936015777056047	1.14363252025096	1.23386188251721	NA	NA	1.16297918753356	1.09084250463536	0.720976442598828	0.666840354765782	0.659705241616309	0.760713222351817	0.801792194740958	NA	NA	0.724962439119042	0.716990446078615	NA	NA	p.Thr6Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.797	-3.544	1.747	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6W	6	T	W	missense	wt-like	1.06477225397332	0.153561638591826	6	0.0626912764359426	0.941899610014026	1.18764489793261	1.25997347985629	1.207907056322	0.851786514230361	1.09909881149869	NA	NA	0.988484080501124	0.981383581431433	0.705432154389785	0.741653215144463	0.71849133623344	0.673388518799653	0.757158143746561	NA	NA	0.689067910141389	0.692372972546131	NA	NA	p.Thr6Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.797	-5.426	3.629	0.001427476	NA	NA	NA	NA	NA	NA	NA
T6X	6	T	X	nonsense	possibly_low	0.471506228586068	0.415694712626394	6	0.169706655784592	0.138887295311532	0.804125161860604	0.963850579256606	0.929041279369941	0.501533155946911	0.384149191893296	NA	NA	-0.0267982191952274	0.0772613842448801	0.544475760121234	0.678579401590867	0.658197273129827	0.568587459167907	0.520364061074561	NA	NA	0.48021918912726	0.48903455473707	NA	NA	p.Thr6Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T6Y	6	T	Y	missense	possibly_wt-like	0.823903866497038	0.223484003667845	6	0.0912369624434175	0.645082706049106	1.00272502694497	1.0534941578583	1.10538551708036	0.806461677763806	0.768900579222461	NA	NA	0.509050856195648	0.700130410861652	0.653810929119568	0.697673373558419	0.696324972816325	0.659826647722641	0.647795210516495	NA	NA	0.590446063057258	0.62911871898903	NA	NA	p.Thr6Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.797	-4.28	2.483	0.001427476	NA	NA	NA	NA	NA	NA	NA
S7A	7	S	A	missense	low	0.371558302944022	0.387642116725723	6	0.15825423146507	0.0613857088714203	0.681730897016624	0.784431475520008	0.910535582954387	0.31144735541525	0.190039575831997	NA	NA	0.0447510699763021	-0.011855242033812	0.503324088391029	0.640363353206504	0.654196123760941	0.511710935801228	0.456074204541148	NA	NA	0.494937240980831	0.468992093834795	NA	NA	p.Ser7Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.099	-2.099	0	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7C	7	S	C	missense	wt-like	1.16776032724952	0.294982045939744	6	0.120425915972433	0.931729869138306	1.40379078536074	0.902789151619948	0.986133405841087	0.859152819466181	1.30191232058564	NA	NA	1.59183190234203	1.36474236364224	0.727091778422334	0.665573392618675	0.670541262821909	0.675592627842514	0.824330763356094	NA	NA	0.813179618733	0.778590929002155	NA	NA	p.Ser7Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.099	-4.861	2.762	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7D	7	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser7Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.099	-3.775	1.676	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7E	7	S	E	missense	wt-like	1.15955118995398	0.127244618381901	6	0.0519473979251379	1.05773616093014	1.26136621897782	1.1226845351785	0.94737878630237	1.18598635541314	1.33481786876546	NA	NA	1.1512662930488	1.21517330101563	0.733752831573057	0.712410838813417	0.662162057952946	0.773386125264775	0.835229208340734	NA	NA	0.722553037287405	0.744952625858708	NA	NA	p.Ser7Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.099	-3.637	1.538	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7F	7	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser7Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.099	-3.076	0.977	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7G	7	S	G	missense	wt-like	1.12400676382476	0.0796150119099892	6	0.0325026925075132	1.06030265710946	1.18771087054007	1.15238388230012	1.02682117842054	1.05140446590378	1.09753989019808	NA	NA	1.23420783668494	1.18168332944113	0.735268943287558	0.718736763215815	0.679338438130633	0.733117204798325	0.756641822974841	NA	NA	0.739614533693407	0.737420681776791	NA	NA	p.Ser7Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.099	-2.706	0.607	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7H	7	S	H	missense	possibly_low	0.54805486089823	0.336691416344292	6	0.137453695136414	0.27865056888891	0.81745915290755	1.1572662568813	0.687191750193119	0.39237287190836	0.199644024910766	NA	NA	0.446549848423649	0.405304413072186	0.570200602570692	0.719776702995578	0.605906558460049	0.535925064457378	0.459255235269484	NA	NA	0.57758928860233	0.562811916539054	NA	NA	p.Ser7His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.099	-4.822	2.723	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7I	7	S	I	missense	possibly_wt-like	0.955905790564413	0.331609755019041	6	0.135379115587664	0.690567599753708	1.22124398137512	0.973443059550868	1.58374878757129	0.748272340852572	0.638541131766989	NA	NA	0.849601506491596	0.941827917153168	0.670560824006412	0.680622588093402	0.799752742020105	0.642415525107135	0.604619656699312	NA	NA	0.660499059919421	0.683476845214275	NA	NA	p.Ser7Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.099	-2.838	0.739	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7K	7	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser7Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.099	-3.658	1.559	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7L	7	S	L	missense	possibly_wt-like	0.832964895875239	0.167864697432887	6	0.0685304757562099	0.698647631549672	0.967282160200805	0.925283556942468	0.836364234866452	1.01961690146039	0.937984815989714	NA	NA	0.563590145618326	0.714949720374086	0.654262039310715	0.670364673280989	0.638159405340442	0.723605888609648	0.703796564516369	NA	NA	0.601665071646645	0.632451603590977	NA	NA	p.Ser7Leu	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.099	-2.304	0.205	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7M	7	S	M	missense	wt-like	1.02607530299782	0.106039232164734	6	0.0432903352533533	0.941227805022583	1.11092280097306	0.867771098932201	1.01373253243027	1.01933862942861	1.05299010489718	NA	NA	1.19856917965992	1.00405027263874	0.710496685163525	0.658114590473471	0.676508518819976	0.72352262544284	0.741886761563122	NA	NA	0.732283481097925	0.69747074488421	NA	NA	p.Ser7Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.099	-4.448	2.349	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7N	7	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser7Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.099	-3.884	1.785	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7P	7	S	P	missense	possibly_low	0.657938833589705	0.245455095590864	6	0.100206623160614	0.461537461182524	0.854340205996887	0.972523157954661	0.885017485057168	0.573403708291456	0.727359210483752	NA	NA	0.402446577878774	0.386882861872421	0.612064377509989	0.680426650185022	0.648678810658862	0.59009220669964	0.634036548320337	NA	NA	0.568517022052828	0.558668882460027	NA	NA	p.Ser7Pro	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.099	-2.689	0.59	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7Q	7	S	Q	missense	wt-like	1.11988464293146	0.179146528089055	6	0.0731362638348929	0.976540199851247	1.26322908601167	1.04805234810095	1.24974017373168	1.05511392271697	1.19088590661667	NA	NA	0.835622516241473	1.339892990181	0.730881639252142	0.696514274774318	0.727536148574659	0.734227129929625	0.787558385097253	NA	NA	0.657623510689734	0.773002268200684	NA	NA	p.Ser7Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.099	-3.1	1.001	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7R	7	S	R	missense	wt-like	1.01771980443234	0.0275765972484057	6	0.0112580986834721	0.995654336478335	1.03978527238634	0.997972551993793	0.992889235084048	0.988843601244972	1.03591383773581	NA	NA	1.03813380664653	1.05256579388887	0.703831534019205	0.68584733980891	0.672001952617353	0.714398055494937	0.736231035751044	NA	NA	0.699281110752954	0.708381957285456	NA	NA	p.Ser7Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.099	-4.006	1.907	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7S	7	S	S	synonymous	possibly_wt-like	0.774830918670965	0.191316736310466	6	0.0781047305358732	0.621748459798448	0.927913377543483	0.943198329944166	0.787052291503737	0.636183515651337	1.05469299381481	NA	NA	0.562993421488707	0.66486495962303	0.62434252485672	0.674180497892581	0.627497582805709	0.608876866943977	0.74245076496712	NA	NA	0.601542322465154	0.621187466907732	NA	NA	p.Ser7=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7T	7	S	T	missense	wt-like	0.918922356746549	0.169405627090776	6	0.0691595576547678	0.783372114556483	1.05447259893662	0.948373495530733	1.22625943364978	0.913340791837904	0.808597008053237	NA	NA	0.732419978145308	0.884543433262329	0.67293814097852	0.675282801796315	0.722459336211051	0.691806482155529	0.660942821470573	NA	NA	0.636394224910555	0.670593480160726	NA	NA	p.Ser7Thr	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.099	-2.769	0.67	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7V	7	S	V	missense	wt-like	0.797265314459202	0.0714914291762593	6	0.0291862537440262	0.740061308277264	0.854469320641141	0.803055033402606	0.886120649960874	0.812133273555916	0.854287477082832	NA	NA	0.725971970560607	0.702023482192379	0.646623738010312	0.644330148125819	0.648917327894805	0.661523674274304	0.676075681750557	NA	NA	0.635067837030497	0.62954447352795	NA	NA	p.Ser7Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.099	-2.21	0.111	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7W	7	S	W	missense	wt-like	0.974025934835922	0.106824862146289	6	0.0436110673502603	0.888549813502061	1.05950205616978	1.08200099454811	1.07173768942297	0.959298669024145	0.785801272258506	NA	NA	0.982718302947569	0.96259868081423	0.688599068551564	0.703745294705803	0.689049916456782	0.705557768513349	0.653392785498352	NA	NA	0.687881860440659	0.688148220646345	NA	NA	p.Ser7Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.099	-5.358	3.259	0.001493052	NA	NA	NA	NA	NA	NA	NA
S7X	7	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser7Ter	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S7Y	7	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser7Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.099	-4.157	2.058	0.001493052	NA	NA	NA	NA	NA	NA	NA
L8A	8	L	A	missense	wt-like	1.25043725471441	0.179996934092606	6	0.0734834406320432	1.10641235761551	1.3944621518133	1.19592929151788	1.01721087342377	1.13804367387652	1.22382513335759	NA	NA	1.45297301079261	1.47464154531806	0.771828297890328	0.728011881812026	0.677260577081303	0.759040955667404	0.79846798455175	NA	NA	0.784615640113252	0.803307417315361	NA	NA	p.Leu8Ala	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.999	-2.364	0.365	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8C	8	L	C	missense	wt-like	1.11114343995744	0.145482057512956	6	0.0593928012728296	0.994735688521745	1.22755119139313	1.11304997855751	1.10500946139214	0.961210618210098	0.939438982561301	NA	NA	1.29315072286452	1.25500087615906	0.708244271249855	0.710358690105048	0.696243665150523	0.706129852394662	0.704278190116171	NA	NA	0.751739384481377	0.753909906345833	NA	NA	p.Leu8Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.999	-3.075	1.076	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8D	8	L	D	missense	wt-like	1.36977031804979	0.377739212553934	6	0.154211387766309	1.06752155202189	1.6720190840777	0.877019976692627	1.01384689748069	1.46671119602931	1.51246859305386	NA	NA	1.92798850380612	1.42058674123615	0.824266810649853	0.66008459005898	0.676533245889902	0.857383209277655	0.89406781618153	NA	NA	0.88232873745321	0.791150412022052	NA	NA	p.Leu8Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.999	-3.009	1.01	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8E	8	L	E	missense	wt-like	1.04563765926424	0.151973182669785	6	0.0620427920212921	0.924036021402194	1.16723929712628	1.04667296538098	1.30320318140662	1.07227391365625	1.03876132876481	NA	NA	0.837034509330378	0.975880057046368	0.716697301879315	0.696220467951806	0.739095480069881	0.73936165666913	0.737174135806824	NA	NA	0.657913964833165	0.691135221781561	NA	NA	p.Leu8Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.999	-2.984	0.985	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8F	8	L	F	missense	wt-like	1.22861291635627	0.293432173437522	6	0.119793183172964	0.99382259174385	1.46340324096869	0.900257574592562	0.898222850347661	1.20449569477149	1.429708334534	NA	NA	1.3014689269108	1.6375241169811	0.766187439279607	0.665034169826049	0.651533966055962	0.778924397295473	0.866657298068765	NA	NA	0.75345048126374	0.839939948309176	NA	NA	p.Leu8Phe	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.999	-4.16	2.161	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8G	8	L	G	missense	wt-like	0.984907762578094	0.0765542377761592	6	0.0312531366998811	0.92365274024242	1.04616278491377	1.07855388442848	1.07594929886551	0.97278497036753	0.964864636018636	NA	NA	0.914324464430854	0.902969321357553	0.696485790238901	0.703011064490767	0.689960515987036	0.709593072209583	0.712699265002663	NA	NA	0.673812900798858	0.674737489613948	NA	NA	p.Leu8Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.999	-3.567	1.568	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8H	8	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu8His	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.999	-3.404	1.405	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8I	8	L	I	missense	wt-like	1.26963112556628	0.326695062563841	6	0.133372700794673	1.00822543548789	1.53103681564468	0.921350961689286	0.83105915446299	1.47195331012235	1.50160807451573	NA	NA	1.62354418292768	1.26827106967966	0.788298694121768	0.669527035329724	0.637012384518769	0.858951728461464	0.890470770384096	NA	NA	0.819702995770831	0.756894392472706	NA	NA	p.Leu8Ile	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.999	-2.948	0.949	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8K	8	L	K	missense	wt-like	0.87402079718416	0.114641902363324	6	0.046802360655352	0.782289855908216	0.965751738460105	0.66813429404509	0.928981400242113	0.928045194072776	0.829887622096388	NA	NA	0.892135149850415	0.996941122798181	0.66862140074093	0.615592196614755	0.65818432655764	0.696206259913602	0.667994355290052	NA	NA	0.669248446191808	0.695871886582704	NA	NA	p.Leu8Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.999	-3.718	1.719	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8L	8	L	L	synonymous	wt-like	1.08361480965959	0.171521961635218	6	0.0700235476145861	0.946371178265271	1.2208584410539	0.952746781961308	0.906814612295885	1.02181993868799	1.05282923130122	NA	NA	1.36695064715742	1.20052764655369	0.732961933467181	0.67621430642625	0.653391606110397	0.724265070400202	0.741833479605153	NA	NA	0.766920403400079	0.74165879653416	NA	NA	p.Leu8=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8M	8	L	M	missense	wt-like	1.3548311698668	0.0983241639171332	6	0.0401406718304583	1.27615689876386	1.43350544096974	1.21034675531358	1.26960135069812	1.39355959665017	1.46923009050926	NA	NA	1.42972077582028	1.35652845020941	0.778288072562282	0.731082783864937	0.731830368792053	0.835495153253688	0.879747056696672	NA	NA	0.779832537387888	0.776743607736677	NA	NA	p.Leu8Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.999	-3.357	1.358	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8N	8	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu8Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.999	-3.921	1.922	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8P	8	L	P	missense	wt-like	0.862737556668824	0.0742867206945984	6	0.0303274267277363	0.803296892538684	0.922178220798965	0.807812795353325	0.885530896895	0.983572010550272	0.853177170134315	NA	NA	0.767344315220642	0.878988151859392	0.659066952753603	0.645343545568584	0.648789816340831	0.712820716469675	0.67570794378952	NA	NA	0.643578338267629	0.669344089166375	NA	NA	p.Leu8Pro	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.999	-2.611	0.612	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8Q	8	L	Q	missense	possibly_low	0.534693236720616	0.458142251738772	6	0.187035791061619	0.168109822419885	0.901276651021347	1.12718234710287	0.985600259153275	0.406168884870808	-0.110296620625784	NA	NA	0.514125728768589	0.285378821053937	0.56577151430708	0.713368867220347	0.670425990233104	0.540053038516624	0.356601693215566	NA	NA	0.591489990097536	0.535840473727796	NA	NA	p.Leu8Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.999	-4.103	2.104	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8R	8	L	R	missense	wt-like	0.989660818795493	0.0883758748044502	6	0.0360792998071652	0.918946690586026	1.06037494700496	0.978490212415611	1.093547403869	1.07946398781361	0.860392786265303	NA	NA	0.931877620102029	0.994192902307404	0.687731529427773	0.681697625444862	0.693765433410685	0.741513034729329	0.678097783794741	NA	NA	0.677423673992464	0.695253807734376	NA	NA	p.Leu8Arg	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.999	-4.051	2.052	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8S	8	L	S	missense	wt-like	0.964686550487145	0.185681934601625	6	0.0758043323711362	0.816112789167615	1.11326031180668	1.18429177970284	1.06841559642164	0.943615598458489	1.09730672666743	NA	NA	0.767354591805669	0.7271350098668	0.694598399679064	0.725533106111251	0.688331640850334	0.700865158507794	0.756564598310557	NA	NA	0.643580452213317	0.635192093199244	NA	NA	p.Leu8Ser	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.999	-2.376	0.377	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8T	8	L	T	missense	possibly_wt-like	0.849940202624264	0.23623666154123	6	0.0964432132190973	0.660914978161516	1.03896542708701	1.14454820274634	0.515503728919257	0.826613499623196	0.901309525408744	NA	NA	1.0522316746172	0.659434584430848	0.678752970704892	0.717067773109882	0.568785587568737	0.66585637515973	0.691649566250053	NA	NA	0.702181113732994	0.619966167504704	NA	NA	p.Leu8Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.999	-2.505	0.506	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8V	8	L	V	missense	possibly_wt-like	0.81687919225082	0.197488704640998	6	0.0806244260556103	0.658858220907611	0.974900163594029	1.09512901436442	0.891012324124893	0.655136913891897	0.612195812121227	NA	NA	0.972116279278839	0.675684809723641	0.636797916300725	0.706541546777307	0.649974965421902	0.614548008054423	0.595893984809785	NA	NA	0.685700970372903	0.623620867179549	NA	NA	p.Leu8Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.999	-2.618	0.619	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8W	8	L	W	missense	possibly_wt-like	0.777231201515199	0.1565722912344	6	0.0639203702304538	0.651949577985043	0.902512825045354	0.945606415715172	0.912890171822846	0.544501517312164	0.651376466579562	NA	NA	0.851038343641684	0.757974294019765	0.64841655367548	0.67469341719951	0.654705213586769	0.581444237540533	0.608870769294363	NA	NA	0.660794624612307	0.642127893764192	NA	NA	p.Leu8Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.999	-5.448	3.449	0.001418913	NA	NA	NA	NA	NA	NA	NA
L8X	8	L	X	nonsense	possibly_wt-like	0.849314036490844	0.188392897581044	6	0.0769110783729948	0.698571092867637	1.00005698011405	0.517571542383057	0.97479332211223	0.83762452694114	1.07451773855266	NA	NA	0.865457779888991	0.825919309066989	0.665925089535297	0.583522515724775	0.668089403251972	0.669151039731142	0.749016797196069	NA	NA	0.663760775818622	0.65740882802364	NA	NA	p.Leu8Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L8Y	8	L	Y	missense	possibly_wt-like	0.804305210039493	0.16827538966054	4	0.08413769483027	0.639398358429941	0.969212061649044	0.871910540050636	0.627551758485067	NA	NA	NA	NA	0.711942378242099	1.00581616338017	0.645589082519076	0.658996286339585	0.593011690316503	NA	NA	NA	NA	0.632181878698567	0.697867896320711	NA	NA	p.Leu8Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.999	-4.26	2.261	0.001418913	NA	NA	NA	NA	NA	NA	NA
D9A	9	D	A	missense	wt-like	1.08747050542767	0.271576662319044	5	0.121452775609578	0.849427439410473	1.32551357144487	1.11542455743269	0.721574972900566	1.18445546697807	NA	NA	NA	0.961049534928678	1.45484799489835	0.710864472484384	0.710864472484384	0.613340615884689	0.772928060477164	NA	NA	NA	0.68342448490279	0.798855818584909	NA	NA	p.Asp9Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.812	-2.438	0.626	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9C	9	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp9Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.812	-5.094	3.282	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9D	9	D	D	synonymous	wt-like	0.931033650511957	0.175912909008682	6	0.0718161443733197	0.790276594031721	1.07179070699219	0.94208067243741	1.22813247945007	0.98485196892448	0.795732593809185	NA	NA	0.719096474995673	0.916307713454924	0.675839875960003	0.673942438218522	0.722864310757992	0.713203699218389	0.656682077655206	NA	NA	0.633653512703653	0.677737313701484	NA	NA	p.Asp9=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9E	9	D	E	missense	possibly_wt-like	0.882446670798284	0.34819615427968	6	0.142150484730771	0.603836840341062	1.1610565012555	0.231265582149404	0.762934348639883	1.19234582896705	1.05269838894491	NA	NA	1.04577598298391	1.00965989310454	0.699792751009611	0.522539698392883	0.622282999701047	0.775288975162964	0.741790144110056	NA	NA	0.700853145205149	0.698732356814073	NA	NA	p.Asp9Glu	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.812	-2.327	0.515	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9F	9	D	F	missense	wt-like	0.942312626362968	0.109984726740563	6	0.0449010766689701	0.854308133224715	1.03031711950122	0.930242317886938	1.15557130042504	0.908580689243732	0.852648676830801	NA	NA	0.939850875053457	0.866981898737844	0.677298358878197	0.671420883262166	0.707175729839868	0.690382188043775	0.675532904760793	NA	NA	0.6790638129956	0.666643865102473	NA	NA	p.Asp9Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.812	-4.375	2.563	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9G	9	D	G	missense	wt-like	1.01080132412824	0.137788705588505	6	0.0562520035017357	0.900549423206614	1.12105322504986	0.813385903104001	0.891186409612493	1.11762348360085	1.13421708232737	NA	NA	0.979233622812065	1.12916144331264	0.706386738024927	0.646530610663747	0.65001260475323	0.752930928373846	0.768789451041324	NA	NA	0.687165044054063	0.725608431995791	NA	NA	p.Asp9Gly	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.812	-2.268	0.456	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9H	9	D	H	missense	possibly_wt-like	0.926394150922333	0.55966614543558	3	0.323123399723552	0.293083924902031	1.55970437694263	1.33738508176808	1.15280265100409	NA	NA	NA	NA	0.288994719994824	NA	0.706577115249284	0.75814179112417	0.706577115249284	NA	NA	NA	NA	0.54517939918397	NA	NA	NA	p.Asp9His	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.812	-4.621	2.809	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9I	9	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp9Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.812	-3.957	2.145	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9K	9	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp9Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.812	-3.43	1.618	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9L	9	D	L	missense	low	0.475063411733345	0.206868871262116	3	0.119435798510136	0.240973548188695	0.709153275277995	NA	NA	NA	0.511929321507554	NA	NA	0.661020790325228	0.252240123367253	0.562685334834267	NA	NA	NA	0.562685334834267	NA	NA	0.621707049666654	0.528387531662186	NA	NA	p.Asp9Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.812	-3.597	1.785	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9M	9	D	M	missense	possibly_low	0.662076217646057	0.223624360780603	6	0.0912942629947552	0.483142750181209	0.841009685110905	0.291750296408917	0.564986834060068	0.640894170349939	0.799520183447248	NA	NA	0.943666504516669	0.731639317093502	0.623245742026132	0.535422868125183	0.579484417294392	0.610286365503511	0.657936542010859	NA	NA	0.679848707338281	0.636205118548753	NA	NA	p.Asp9Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.812	-4.761	2.949	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9N	9	D	N	missense	possibly_wt-like	0.863572385680013	0.258393447267121	6	0.105488683113867	0.656818366000276	1.07032640535975	0.655400449864356	0.463356478491566	1.1475928048952	0.985690929770328	NA	NA	1.04923882312058	0.880154827938044	0.685585972666579	0.612879903468735	0.557510738276249	0.761898198933322	0.719597014143521	NA	NA	0.70156546899316	0.669606476339997	NA	NA	p.Asp9Asn	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.812	-3.597	1.785	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9P	9	D	P	missense	wt-like	1.20151634207355	0.296211377355235	6	0.120927788421221	0.964502232037877	1.43853045210922	0.815805306686521	0.852620792881369	1.33150991060781	1.33773228865463	NA	NA	1.54307821785716	1.32835153575381	0.786778658243845	0.647045940650606	0.641674264515748	0.816928956261527	0.836194475494184	NA	NA	0.803150738437898	0.770406578049791	NA	NA	p.Asp9Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.812	-3.89	2.078	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9Q	9	D	Q	missense	possibly_low	0.397640595273229	0.648189910496383	6	0.264622422856073	-0.121009823026402	0.916291013572861	1.1437054507006	1.14440329540205	0.0700120961640539	0.533604039677954	NA	NA	-0.168842251229951	-0.337039059075331	0.510432048187547	0.716888267960848	0.70476107571143	0.439469883992343	0.569864085428143	NA	NA	0.45100001094695	0.395857772987355	NA	NA	p.Asp9Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.812	-2.742	0.93	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9R	9	D	R	missense	possibly_low	0.681301996536882	0.264799419579216	6	0.108103910359038	0.469422225645221	0.893181767428543	0.928708088031754	0.996817594509813	0.735722524988805	0.665513194344208	NA	NA	0.433862237387901	0.327188339958812	0.62610667009563	0.671094094190337	0.672851310160252	0.638660431916446	0.613552908274814	NA	NA	0.574979382630037	0.545243496294801	NA	NA	p.Asp9Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.812	-2.533	0.721	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9S	9	D	S	missense	possibly_low	0.710403615720132	0.0878615366856161	6	0.0358693221494307	0.640101036157383	0.780706195282881	0.576401538666269	0.68738497222787	0.670252312669265	0.722183163612146	NA	NA	0.82734612783881	0.778853579306434	0.625696491848136	0.596053232563666	0.6059483353381	0.619070762144171	0.632322221552102	NA	NA	0.655921015597453	0.64682367587018	NA	NA	p.Asp9Ser	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.812	-2.537	0.725	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9T	9	D	T	missense	wt-like	0.972326348554939	0.237332326850636	6	0.0968905167085829	0.78242442536264	1.16222827174724	0.894544495034186	0.843243891666813	0.61023154467175	1.05711093348217	NA	NA	1.25568896390193	1.17313826257279	0.699658087261243	0.663817290908032	0.63964686811119	0.601111647870782	0.743251595948475	NA	NA	0.744033310566156	0.735498883614453	NA	NA	p.Asp9Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.812	-2.814	1.002	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9V	9	D	V	missense	wt-like	1.02259819162406	0.0946472860850713	6	0.0386395927412745	0.946865981473863	1.09833040177425	0.935370802097257	1.10259947806563	1.06115244402315	1.12571633598952	NA	NA	0.886006336122285	1.0247437534465	0.698923668839649	0.672513244090184	0.695722598390898	0.736033946100062	0.765973970934892	NA	NA	0.66798771810777	0.702124739288401	NA	NA	p.Asp9Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.812	-2.908	1.096	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9W	9	D	W	missense	possibly_low	0.709960243314587	0.276888594073082	6	0.113039295179278	0.48840729592541	0.931513190703765	0.935773597263206	1.04855789507985	0.85239679041888	0.606841981964555	NA	NA	0.360501729418712	0.455689465742321	0.63335990724705	0.672599038965035	0.684038172103896	0.673571122591201	0.594120775529066	NA	NA	0.559888753878907	0.574143589318521	NA	NA	p.Asp9Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.812	-5.478	3.666	0.001193295	NA	NA	NA	NA	NA	NA	NA
D9X	9	D	X	nonsense	possibly_wt-like	0.789088183336301	0.10901850550735	6	0.0445066185023008	0.701856813998128	0.876319552674475	0.649967131173117	0.887551714953623	0.827783114915817	0.913765428438768	NA	NA	0.673859332595559	0.781602377940925	0.648334312866561	0.611722613271272	0.649226740989238	0.666206341602961	0.695775009569365	NA	NA	0.624348002959788	0.647441884743884	NA	NA	p.Asp9Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D9Y	9	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp9Tyr	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.812	-4.373	2.561	0.001193295	NA	NA	NA	NA	NA	NA	NA
I10A	10	I	A	missense	wt-like	0.948177499232604	0.115745587075361	6	0.0472529380522523	0.855563442486487	1.04079155597872	1.02306390192183	0.912574242285997	0.821228512273868	1.112192699791	NA	NA	0.825806632640345	0.99419900648258	0.67771843631585	0.691191766477581	0.654636905902551	0.66424510615412	0.761494890255354	NA	NA	0.655604333623087	0.695255180572391	NA	NA	p.Ile10Ala	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.972	-2.495	0.523	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10C	10	I	C	missense	wt-like	0.954258964085966	0.158502458536815	6	0.0647083577319741	0.827432913432563	1.08108501473937	0.827982816777812	1.12521023004619	1.02780731457804	1.08735832829549	NA	NA	0.942040842061426	0.715154252756833	0.690062804704784	0.649639735319947	0.700611309087622	0.726056583094803	0.753269650244373	NA	NA	0.679514300321947	0.632497603226013	NA	NA	p.Ile10Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.972	-4.887	2.915	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10D	10	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile10Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.972	-3.874	1.902	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10E	10	I	E	missense	wt-like	1.18539997988367	0.219083246780689	6	0.089440360967489	1.01010009362313	1.36069986614421	1.12033757566427	0.840487197344783	1.05322601301145	1.3900926262856	NA	NA	1.33860539623954	1.36965107075636	0.747375940236071	0.711910939323987	0.639050838353697	0.733662239021519	0.853536422084163	NA	NA	0.761089641450624	0.779694904483763	NA	NA	p.Ile10Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.972	-3.809	1.837	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10F	10	I	F	missense	wt-like	1.28672006945781	0.318104043022791	6	0.129865431753698	1.03218850038382	1.5412516385318	1.36850990724441	1.35097141208862	1.50039325410057	1.45266462914357	NA	NA	1.40057390843692	0.647207305732763	0.769304109763162	0.764771340662577	0.74942353375423	0.86746138638278	0.874260511742231	NA	NA	0.773836878863748	0.617216234462118	NA	NA	p.Ile10Phe	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.972	-3.127	1.155	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10G	10	I	G	missense	wt-like	0.87622568104697	0.0716618269866581	6	0.0292558183588203	0.818885330725437	0.933566031368504	0.798824030659609	0.96854690124571	0.814384147255497	0.926485961490651	NA	NA	0.923581112478387	0.825531933151967	0.664468011498994	0.643428949746308	0.666738853543025	0.662197169454962	0.699988099376703	NA	NA	0.675717040274335	0.65732170660808	NA	NA	p.Ile10Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.972	-2.85	0.878	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10H	10	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile10His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.972	-4.884	2.912	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10K	10	I	K	missense	wt-like	1.1202228239941	0.147840475614619	2	0.104539002840941	0.91533014344612	1.32511550454207	1.01568382115315	1.22476182683504	NA	NA	NA	NA	NA	NA	0.705877677171979	0.689619818352423	0.722135535991535	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile10Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.972	-3.8	1.828	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10L	10	I	L	missense	possibly_wt-like	0.88299883925212	0.212959034273602	4	0.106479517136801	0.674302820572775	1.09169485793147	0.856556281729851	0.782008771069949	NA	NA	NA	NA	0.704809270541373	1.18862103366731	0.643220205226691	0.655725848205223	0.626407114327924	NA	NA	NA	NA	0.630714562248159	0.738980981706345	NA	NA	p.Ile10Leu	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.972	-2.442	0.47	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10M	10	I	M	missense	wt-like	0.973962153542079	0.169169656124667	6	0.0690632229112548	0.838600723979758	1.1093235831044	1.05382248162313	0.727453987337052	0.852384388633529	0.986247469299161	NA	NA	1.21904044762942	1.00482414673019	0.697694048213532	0.697743306116442	0.614611727999251	0.67356741179096	0.719781342190682	NA	NA	0.736494524799016	0.697644790310622	NA	NA	p.Ile10Met	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.972	-3.31	1.338	0.001878584	NA	NA	NA	NA	4.06e-06	NA	NA
I10N	10	I	N	missense	possibly_wt-like	0.775358148811305	0.252270306082669	3	0.145648329125378	0.489892669317128	1.06082362830548	0.616729540798796	1.06625702425663	NA	NA	NA	NA	0.643087881378493	NA	0.618018159297238	0.6046430474086	0.68786493214282	NA	NA	NA	NA	0.618018159297238	NA	NA	NA	p.Ile10Asn	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.972	-2.831	0.859	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10P	10	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile10Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.972	-4.098	2.126	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10Q	10	I	Q	missense	wt-like	1.1528404494169	0.149521560578561	6	0.0610419214936863	1.03320048174215	1.27248041709164	1.10407212430217	0.868415838012853	1.22568863157456	1.2236635455761	NA	NA	1.25822620734945	1.23697634968624	0.747205699066383	0.708446418192724	0.645089339173854	0.785265641943506	0.798414466052769	NA	NA	0.744555234418344	0.749856163714423	NA	NA	p.Ile10Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.972	-4.228	2.256	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10R	10	I	R	missense	wt-like	0.964111407459249	0.135879615535779	6	0.0554726207513688	0.855387068658517	1.07283574625998	1.11746499717518	1.11046082173465	0.892370448678618	0.759584784886	NA	NA	0.960404970326225	0.944382421954815	0.68479159899161	0.711299083639499	0.69742231341667	0.685531840865278	0.644709783356633	NA	NA	0.683291894693276	0.684051357117941	NA	NA	p.Ile10Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.972	-4.111	2.139	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10S	10	I	S	missense	wt-like	0.910213358016046	0.134863105437799	6	0.0550576322416291	0.802302381748402	1.01812433428369	1.06700314240909	1.05294370581245	0.92036964745523	0.713515976765076	NA	NA	0.833597293401458	0.873850382252973	0.676587516597592	0.700550770649725	0.684986436003332	0.693909621209797	0.629451615704474	NA	NA	0.657206912074716	0.668188597191853	NA	NA	p.Ile10Ser	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.972	-2.679	0.707	0.001878584	NA	NA	NA	NA	4.06e-06	NA	NA
I10T	10	I	T	missense	wt-like	1.28352252978337	0.0945457521285543	6	0.0385981416771024	1.20787156222608	1.35917349734067	1.12410878409809	1.3391628612668	1.35413361676124	1.27333279306478	NA	NA	1.23393689476554	1.37646022874381	0.764048340129735	0.712714202081256	0.746870386085143	0.823698308564945	0.814865113166312	NA	NA	0.739558799565714	0.781226294174326	NA	NA	p.Ile10Thr	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.972	-2.328	0.356	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10V	10	I	V	missense	wt-like	0.944751116702353	0.103031943974682	6	0.0420626149908325	0.862309906224747	1.02719232717996	1.04566911269787	0.991016360997814	0.765211043215186	1.02913220879168	NA	NA	0.913999567255127	0.92347840725644	0.676548040565937	0.696006648565187	0.671597015197011	0.64748383898452	0.733984933982736	NA	NA	0.673746067801147	0.679350013330728	NA	NA	p.Ile10Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.972	-1.953	-0.019	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10W	10	I	W	missense	wt-like	0.911063080926042	0.158035488563518	6	0.0645177180386775	0.784610677205524	1.03751548464656	0.68019433328704	0.886894939969569	0.89032130961119	0.876089365020595	NA	NA	0.963836395738757	1.1690421419291	0.683647153888486	0.618160970137692	0.649084738507735	0.684918707713174	0.683296551463852	NA	NA	0.68399775631312	0.734577660030481	NA	NA	p.Ile10Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.972	-5.392	3.42	0.001878584	NA	NA	NA	NA	NA	NA	NA
I10X	10	I	X	nonsense	possibly_wt-like	0.739945165549291	0.156898511731136	6	0.0640535491905606	0.614402516053827	0.865487815044754	0.653263306698428	1.02940547032232	0.746327958536946	0.656125964476393	NA	NA	0.585450972854515	0.769097320407138	0.62712921567511	0.612424694603389	0.67989719245577	0.641833736746831	0.610443821390332	NA	NA	0.6061619547401	0.644629478830784	NA	NA	p.Ile10Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I10Y	10	I	Y	missense	possibly_wt-like	1.00508071811172	0.366763915924938	6	0.149730741680188	0.711613857040085	1.29854757918336	0.572639379370821	1.11479421992656	1.18927018638558	1.31268396691922	NA	NA	0.513916195901114	1.32718036016705	0.734251212019042	0.595251897261738	0.698359245107936	0.774368696758879	0.827898374335222	NA	NA	0.591446888123439	0.770143178930148	NA	NA	p.Ile10Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.972	-4.165	2.193	0.001878584	NA	NA	NA	NA	NA	NA	NA
E11A	11	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu11Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.054	-2.781	0.727	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11C	11	E	C	missense	wt-like	1.05628572471836	0.120346281269743	6	0.0491311635920558	0.959990413559383	1.15258103587733	0.817956041820236	1.14505117116753	1.06146753272481	1.1229819803286	NA	NA	1.08410650483463	1.10615111743435	0.714585651883739	0.647504044588371	0.704901154077137	0.736128225366858	0.765068341751142	NA	NA	0.708737928054924	0.720433375712555	NA	NA	p.Glu11Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.054	-5.203	3.149	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11D	11	E	D	missense	wt-like	1.46214896717272	0.229353330779968	6	0.0936331052031149	1.27863145321396	1.64566648113147	1.23895775076499	1.25395773258596	1.62115059701869	1.76588847971487	NA	NA	1.60744469551381	1.28549454743798	0.788579613789553	0.737176890700411	0.728448034437752	0.903593795100162	0.978001464017944	NA	NA	0.81639124951427	0.760767978064835	NA	NA	p.Glu11Asp	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.054	-2.503	0.449	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11E	11	E	E	synonymous	wt-like	1.08387413021653	0.207224239691598	6	0.0845989415967685	0.918063251556653	1.2496850088764	1.05271310261439	1.12729489704162	0.961407364147856	0.781128685899239	NA	NA	1.19051232099571	1.39018841060034	0.703625380179324	0.697507009752277	0.70106203862764	0.706188721731009	0.651845206801466	NA	NA	0.73062614438683	0.784313782554535	NA	NA	p.Glu11=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11F	11	E	F	missense	possibly_wt-like	0.750458777417076	0.247094098745031	6	0.100875743396368	0.552745953446491	0.948171601387661	0.914736505975151	1.06692684054465	0.463075531229902	0.89780003510122	NA	NA	0.491224526800199	0.668989224851337	0.645116592324859	0.668118164399354	0.68800975430773	0.557080360874789	0.69048720946962	NA	NA	0.58677909664237	0.622115020250365	NA	NA	p.Glu11Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.054	-4.416	2.362	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11G	11	E	G	missense	wt-like	0.847224493414227	0.156977894440339	6	0.064085957045885	0.721618325689512	0.972830661138943	1.0558576477162	0.953375836188794	0.693421596672922	0.643900646919595	NA	NA	0.832884733912144	0.903906499075706	0.660259512846475	0.698176793990716	0.663458690721009	0.626003359525656	0.6063947488727	NA	NA	0.65706033497194	0.674948262267256	NA	NA	p.Glu11Gly	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.054	-3.493	1.439	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11H	11	E	H	missense	wt-like	1.00349494703044	0.269102754376086	6	0.109860739433154	0.788171854426518	1.21881803963436	0.637389347979539	1.17148953407945	1.11454974665216	1.25119784213649	NA	NA	1.16111319517156	0.685230016163436	0.71759801716393	0.609043560923538	0.710617439306507	0.752011220163681	0.80753393170076	NA	NA	0.724578595021352	0.625767598209014	NA	NA	p.Glu11His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.054	-4.624	2.57	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11I	11	E	I	missense	wt-like	1.13776735886942	0.137971621995533	6	0.0563266788122028	1.02736909702875	1.24816562071009	0.968579964066144	1.08157830587357	1.24118276933601	1.20473826374351	NA	NA	1.01244316651523	1.31808168368207	0.731046644430043	0.679586754737469	0.691177573553095	0.789901720419492	0.79214633942123	NA	NA	0.693996415712903	0.768096873147183	NA	NA	p.Glu11Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.054	-3.952	1.898	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11K	11	E	K	missense	wt-like	1.03067039680303	0.12956497319765	6	0.0528946788119367	0.92699873135782	1.13434206224824	0.951316307312494	1.2132643857464	1.09699085390673	0.94290891866871	NA	NA	0.869663158613078	1.10987875657077	0.712538550150369	0.675909617085744	0.719649653908386	0.746757336019073	0.705427446392352	NA	NA	0.664625843562015	0.721271727261186	NA	NA	p.Glu11Lys	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.054	-1.999	-0.055	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11L	11	E	L	missense	possibly_low	0.473700474841262	0.464761514709665	6	0.189738093853616	0.101820644392893	0.84558030528963	0.8124373710387	0.998421470716482	0.0948383889993078	0.842175541772126	NA	NA	-0.105750309337158	0.200080385858111	0.581492652070675	0.64632857450067	0.673198087073046	0.446898283276261	0.672064161871906	NA	NA	0.463978343549172	0.51665672964068	NA	NA	p.Glu11Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.054	-2.737	0.683	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11M	11	E	M	missense	possibly_low	0.485254317329559	0.393724121535227	6	0.160737199531142	0.170215195272691	0.800293439386426	0.91390997732598	1.03452806656435	0.263475005733383	0.076269432774116	NA	NA	0.231267881543836	0.392075540035687	0.546570709517302	0.667942114813831	0.681004758053982	0.497356889049688	0.418393092582906	NA	NA	0.533304695584504	0.5598367234501	NA	NA	p.Glu11Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.054	-4.707	2.653	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11N	11	E	N	missense	low	-0.58114977868058	0.525282602493604	3	0.303272051950309	-1.17555207802075	0.0132525206595868	0.0234015525241948	NA	NA	NA	NA	NA	-0.84088042769636	-0.925970460869575	0.312758347845314	0.478264915785632	NA	NA	NA	NA	NA	0.312758347845314	0.263406230694113	NA	NA	p.Glu11Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.054	-2.446	0.392	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11P	11	E	P	missense	wt-like	1.0253201013844	0.167937360054602	6	0.0685601401473057	0.890944695920665	1.15969550684814	1.10998140764145	0.986040087633421	0.750017436063939	0.944594245418171	NA	NA	1.15110343374708	1.21018399780235	0.707845360706478	0.709705088274716	0.670521086327098	0.642937683775951	0.70598563313824	NA	NA	0.722519536302626	0.743830524195333	NA	NA	p.Glu11Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.054	-3.086	1.032	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11Q	11	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu11Gln	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.054	-2.856	0.802	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11R	11	E	R	missense	wt-like	0.940249666550789	0.0979585362204247	6	0.0399914049483308	0.861867953160904	1.01863137994067	1.00655070758375	1.10653594098859	0.896564500753224	0.869882842052099	NA	NA	0.912975953593743	0.848988054333328	0.684013845595467	0.687674476397195	0.696573708005264	0.68678676416915	0.681240927021785	NA	NA	0.673535505276757	0.66259702291355	NA	NA	p.Glu11Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.054	-3.027	0.973	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11S	11	E	S	missense	wt-like	0.939494755718891	0.0859296012581449	6	0.0350806128138791	0.870738018048094	1.00825149338969	1.02220610006459	0.927670902129178	0.917098082407246	0.94667633943748	NA	NA	1.02963231836251	0.793684791912342	0.691969887800762	0.691009055737209	0.657900981441641	0.692930719864316	0.706675230740391	NA	NA	0.697532311472828	0.650159237495433	NA	NA	p.Glu11Ser	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.054	-2.86	0.806	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11T	11	E	T	missense	possibly_low	0.688096725105537	0.202720972223941	6	0.0827604903515964	0.525889144673534	0.850304305537541	0.749672672672242	0.922320790443169	0.836479321462265	0.702067833947626	NA	NA	0.558169881952502	0.359869850155418	0.629309858714221	0.632959770958301	0.656744224326683	0.668808377070403	0.625659946470141	NA	NA	0.600550095905902	0.552593616218488	NA	NA	p.Glu11Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.054	-2.936	0.882	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11V	11	E	V	missense	possibly_low	0.700902609918175	0.148422598551361	6	0.0605932721247973	0.582141978848137	0.819663240988212	0.75754237543919	0.778745567297013	0.765524483829904	0.599630610465577	NA	NA	0.85405206382672	0.449920558650645	0.630168789616269	0.634636007966785	0.625701571265753	0.647577625118977	0.591732341362404	NA	NA	0.661414562147244	0.572846153591184	NA	NA	p.Glu11Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.054	-3.003	0.949	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11W	11	E	W	missense	wt-like	0.978696669784663	0.088861983307089	6	0.0362777527723474	0.907593580910814	1.04979975865851	0.909933068519684	0.975845222663445	1.05242299661007	1.0862487462764	NA	NA	0.84728284477642	1.00044713986195	0.682488615765671	0.667095038130264	0.668316836531547	0.733421964466613	0.752902152382769	NA	NA	0.660022099438751	0.696660394999794	NA	NA	p.Glu11Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.054	-5.564	3.51	0.001850592	NA	NA	NA	NA	NA	NA	NA
E11X	11	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu11Ter	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E11Y	11	E	Y	missense	wt-like	1.09817297088372	0.20655473567637	6	0.084325617727093	0.932897797164522	1.26344814460291	1.09606555000003	1.27902367702215	1.32762904734707	1.18003772948049	NA	NA	0.828855891866183	0.877425929586385	0.720304307177764	0.706741027715617	0.733867586639911	0.815767743749517	0.783965426819935	NA	NA	0.656231581719057	0.668992743069301	NA	NA	p.Glu11Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.054	-4.381	2.327	0.001850592	NA	NA	NA	NA	NA	NA	NA
E12A	12	E	A	missense	wt-like	1.00435183178019	0.0560348714466243	6	0.0228761404744467	0.959515420344991	1.04918824321538	0.921901612888988	0.984880513262867	1.08191754817064	1.01898947414444	NA	NA	1.04271047945394	0.975711362760244	0.695659918880394	0.66964432335788	0.670270372700508	0.742247176798792	0.730625620989597	NA	NA	0.700222555573389	0.691097282187399	NA	NA	p.Glu12Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.643	-2.286	0.643	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12C	12	E	C	missense	wt-like	0.954639517880414	0.0995753576752498	6	0.0406514695432484	0.87496410165702	1.03431493410381	0.906668844181054	0.989424254100984	0.961403278755892	0.833214621769882	NA	NA	1.12604073800071	0.911085370473957	0.673907791998805	0.666399762361606	0.671252782947524	0.70618749932044	0.669096270465796	NA	NA	0.717364012609008	0.676562801050086	NA	NA	p.Glu12Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.643	-5.147	3.504	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12D	12	E	D	missense	wt-like	1.04044339127096	0.168673336637412	6	0.0688606013290592	0.905479092712236	1.17540768982969	1.16267370562011	1.22263114934375	0.992594262337438	1.15506436454668	NA	NA	0.924856859940445	0.784840005837359	0.718224396244888	0.720928482924996	0.721674858440789	0.715520309564781	0.775694151643933	NA	NA	0.675979468000956	0.648170032040747	NA	NA	p.Glu12Asp	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.643	-2.467	0.824	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12F	12	E	F	missense	wt-like	1.05660611130468	0.166524691226493	6	0.0679834205132383	0.923361055552895	1.18985116705647	0.941122183332977	0.974173672322933	1.13657305783302	1.20171445412933	NA	NA	1.25598295090019	0.830070349309655	0.708916033200934	0.673738281218359	0.667955427674522	0.758600925283612	0.791144841967242	NA	NA	0.74409378518351	0.658342403106557	NA	NA	p.Glu12Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.643	-4.294	2.651	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12G	12	E	G	missense	possibly_wt-like	0.795414453476133	0.137143986202721	6	0.0559887979146605	0.685678426025707	0.905150480926558	0.939726287338256	0.995088330420958	0.74744268610496	0.668235687105293	NA	NA	0.693412573040983	0.728581156846345	0.638842306875361	0.673440957088638	0.67247742291157	0.642167279959382	0.6144546084202	NA	NA	0.628370203740724	0.63551733379134	NA	NA	p.Glu12Gly	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.643	-3.368	1.725	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12H	12	E	H	missense	wt-like	0.9928267505897	0.308481850084253	6	0.125937187936026	0.745994397920837	1.23965910325856	0.848995676239324	0.457677345002729	1.21190730539449	1.28258907323986	NA	NA	0.972299387369953	1.18349171629184	0.711783013643732	0.654115448536383	0.556282842775079	0.78114206238989	0.817930829005457	NA	NA	0.685738636636412	0.737827390651051	NA	NA	p.Glu12His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.643	-3.175	1.532	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12I	12	E	I	missense	possibly_wt-like	0.763029725342127	0.209670463794088	6	0.0855976084047016	0.595261495706149	0.930797954978105	0.721069383378311	1.12053560495587	0.799418597340957	0.530407378122184	NA	NA	0.82102232805531	0.585725060200135	0.640743741708638	0.62686730552489	0.699600600124829	0.657719252393147	0.568805338741728	NA	NA	0.654620177892385	0.603388786613967	NA	NA	p.Glu12Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.643	-4.09	2.447	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12K	12	E	K	missense	low	0.482446124614651	0.0931838782864766	6	0.0380421590092468	0.407884863062381	0.55700738616692	0.436686821194664	0.516699197866069	0.390325413524931	0.520629670330985	NA	NA	0.396712426981456	0.6336232177898	0.566815823863681	0.566294169611591	0.569044062025177	0.535312434191142	0.565566924056886	NA	NA	0.567337478115772	0.614161153015941	NA	NA	p.Glu12Lys	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.643	-2.513	0.87	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12L	12	E	L	missense	possibly_low	0.704848282424305	0.309433137282243	6	0.126325549308346	0.457254755452709	0.952441809395901	0.694001514981345	1.1195406116374	0.445084099701893	0.856965315771001	NA	NA	0.263343912880073	0.850154239574118	0.641980591275377	0.621101882853742	0.699385470858746	0.551697054637075	0.67696259229407	NA	NA	0.539902897997553	0.662859299697012	NA	NA	p.Glu12Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.643	-3.616	1.973	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12M	12	E	M	missense	wt-like	0.987935480758842	0.12658641725175	6	0.0516786884389722	0.88664711265019	1.08922384886749	1.04564121715841	1.16400207645535	0.987987337124808	1.01111631763221	NA	NA	0.781240699871898	0.937625236310381	0.702499634846858	0.696000706849597	0.708998562844118	0.714141848423697	0.728018001063771	NA	NA	0.646436895106455	0.682531656084102	NA	NA	p.Glu12Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.643	-4.738	3.095	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12N	12	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu12Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.643	-2.849	1.206	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12P	12	E	P	missense	possibly_low	0.364304305801906	0.537310032522415	5	0.240292351542548	-0.106660048981926	0.835268660585738	1.11508112862219	0.713355171064084	0.102404104679592	0.102904815759888	NA	NA	NA	-0.21222369111622	0.44916205891585	0.710791322570215	0.611563397984217	0.44916205891585	0.427214834573921	NA	NA	NA	0.42392893363139	NA	NA	p.Glu12Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.643	-3.875	2.232	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12Q	12	E	Q	missense	wt-like	1.08131167546434	0.212787086046281	5	0.095161277826716	0.894798998201166	1.26782435272751	1.01263253120241	1.44083527931114	1.09654580350415	NA	NA	NA	0.922562748807779	0.933982014496218	0.688969897346443	0.688969897346443	0.768853159505621	0.746624170261552	NA	NA	NA	0.675507557699688	0.681712290115957	NA	NA	p.Glu12Gln	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.643	-2.476	0.833	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12R	12	E	R	missense	wt-like	0.940696972917875	0.0855332747170759	6	0.0349188131810222	0.872257356700189	1.00913658913556	1.04391283748207	0.915257621232457	0.997585149459958	0.810055750497624	NA	NA	0.888847791960203	0.988522686874937	0.681275393949678	0.695632564104696	0.655217084012957	0.717013657869864	0.661425962617167	NA	NA	0.668572219992364	0.693978567906992	NA	NA	p.Glu12Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.643	-3.664	2.021	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12S	12	E	S	missense	wt-like	0.920187455094687	0.0788879909764751	6	0.0322058874542746	0.857065075594158	0.983309834595215	0.920111006092422	0.990990989490799	0.977742369874854	0.92698691556101	NA	NA	0.935172865759486	0.77012058378955	0.67484652616212	0.669262926312918	0.671591529578583	0.711076400517787	0.700154017304762	NA	NA	0.678101522745656	0.644859612277158	NA	NA	p.Glu12Ser	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.643	-2.714	1.071	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12T	12	E	T	missense	wt-like	0.931992807351314	0.246347213931345	6	0.100570828948007	0.734877604717882	1.12910800998475	1.25094103482186	1.10604645748606	0.874958475802181	1.00441328656111	NA	NA	0.548019614520386	0.807577974916284	0.688394896630359	0.739729315463347	0.696467875911013	0.680321917349704	0.725797931215382	NA	NA	0.598462134388418	0.653283834877451	NA	NA	p.Glu12Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.643	-3.528	1.885	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12V	12	E	V	missense	possibly_wt-like	0.751047180631024	0.110238512639866	6	0.0450046843285044	0.662839620211561	0.839254741050487	0.849157649756123	0.860852944538548	0.749785424863264	0.783236105685715	NA	NA	0.56263680624729	0.700614152695205	0.643161207568331	0.65414994869621	0.643454152592806	0.642868262543857	0.652543192395777	NA	NA	0.60146896490038	0.629227513242029	NA	NA	p.Glu12Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.643	-3.677	2.034	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12W	12	E	W	missense	wt-like	0.929359822330854	0.119403678386116	6	0.048746347576229	0.833818736703574	1.02490090795813	1.04655598840613	0.772655770803688	0.961804629316582	0.878611430245129	NA	NA	1.07594296217027	0.840588153043327	0.690163710616516	0.69619555200006	0.624384885589691	0.706307589429641	0.684131869232973	NA	NA	0.707058645903641	0.660707872704235	NA	NA	p.Glu12Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.643	-3.303	1.66	0.001772277	NA	NA	NA	NA	NA	NA	NA
E12X	12	E	X	nonsense	possibly_low	0.713368011449704	0.185526034364537	6	0.0757406863658622	0.56491899400827	0.861817028891137	0.837679270415387	1.00897279378314	0.621446531205952	0.583456227074499	NA	NA	0.724596853073822	0.504056393145424	0.619626154242617	0.651705068016705	0.675479407304452	0.604467340099688	0.586375322947611	NA	NA	0.634784968385545	0.585021382744053	NA	NA	p.Glu12Ter	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E12Y	12	E	Y	missense	possibly_low	0.41793202787856	0.566666107210829	6	0.231340469532633	-0.0354869605719862	0.871351016329106	1.18072813810702	1.11203278330356	0.0273937339447421	0.0558880578400266	NA	NA	0.137514174016397	-0.00596471994038855	0.492167981578157	0.724774054835137	0.697762190009159	0.426717830615202	0.411642702277397	NA	NA	0.514019082200626	0.470316880955688	NA	NA	p.Glu12Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.643	-4.147	2.504	0.001772277	NA	NA	NA	NA	NA	NA	NA
Y13A	13	Y	A	missense	wt-like	0.974092869164678	0.13529910694768	6	0.0552356291126779	0.865833025440418	1.08235271288894	0.778935366831419	1.02081492192106	1.03191969330501	1.09996029923093	NA	NA	0.831060720508535	1.08186621319111	0.696505739828288	0.639192688816846	0.678039814784469	0.727287068507722	0.757443471819609	NA	NA	0.656685126159011	0.714971664872106	NA	NA	p.Tyr13Ala	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.744	-2.743	0.999	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13C	13	Y	C	missense	wt-like	0.995232498462701	0.300084549960486	6	0.122509004515986	0.755119261829514	1.23534573509589	0.615563868899771	0.615455819304598	1.1226405153099	1.20628435668546	NA	NA	1.28473481606237	1.12671561451411	0.73753327561606	0.604394760728053	0.590396405901844	0.754432099531466	0.792658411390885	NA	NA	0.750008189746349	0.725058361485772	NA	NA	p.Tyr13Cys	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.744	-2.82	1.076	0.001428615	NA	NA	NA	NA	4.06e-06	NA	NA
Y13D	13	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr13Asp	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.744	-3.954	2.21	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13E	13	Y	E	missense	wt-like	0.971316076979391	0.0851617354983507	6	0.0347671329301374	0.903173748590605	1.03945840536818	0.851974546988041	1.02851153837538	0.992383207144332	0.876281216484067	NA	NA	1.0416037351392	1.03714221774533	0.691677493031633	0.654749944341416	0.679703913847657	0.715457158684553	0.683360093411503	NA	NA	0.699994892651763	0.704913172225488	NA	NA	p.Tyr13Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.744	-3.79	2.046	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13F	13	Y	F	missense	wt-like	1.36501030522102	0.321644401039096	5	0.143843749061125	1.08308173766	1.64693887278204	1.19820451434333	1.17945222822845	1.03798185669403	NA	NA	NA	1.78786277747907	1.62155014936023	0.729100958744046	0.728496501474993	0.712339067498901	0.729100958744046	NA	NA	NA	0.853504164491255	0.836347379392863	NA	NA	p.Tyr13Phe	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.744	-2.993	1.249	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13G	13	Y	G	missense	wt-like	0.866906859457643	0.0668588356452608	6	0.0272950053545821	0.813409632004835	0.920404086910452	0.811930789164726	0.961690816814964	0.911974001300998	0.901392769039008	NA	NA	0.806832315379755	0.807620465046409	0.659274939183255	0.646220673184683	0.665256487396024	0.691397517920998	0.691677136862759	NA	NA	0.65170122027897	0.653293390970487	NA	NA	p.Tyr13Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.744	-2.636	0.892	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13H	13	Y	H	missense	wt-like	0.955419881865929	0.214653197569326	6	0.0876318009502792	0.783664708102999	1.12717505562886	0.699057238417395	0.691423164225735	1.10938712070279	0.948227130152715	NA	NA	1.16889029584221	1.11553434185472	0.714866267688653	0.622178745726348	0.606821439975768	0.750466485025014	0.707188858630749	NA	NA	0.726178384093564	0.722543676746557	NA	NA	p.Tyr13His	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.744	-2.569	0.825	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13I	13	Y	I	missense	wt-like	1.22628193766038	0.364084953457497	6	0.148637059832639	0.93495865362048	1.51760522170027	0.698855133717883	0.877569709535198	1.30041662303972	1.38020438566092	NA	NA	1.6594486626752	1.44119711133333	0.801705546417397	0.62213569767397	0.647068513933995	0.807625378130141	0.850261398496832	NA	NA	0.827088729449227	0.795785714704654	NA	NA	p.Tyr13Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.744	-3.707	1.963	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13K	13	Y	K	missense	wt-like	0.889462630838158	0.0596450196424125	6	0.0243499773036984	0.841737552298541	0.937187709377774	0.826204194691666	0.934082378531288	0.846140742163862	0.927161964690076	NA	NA	0.965635271647005	0.83755123330505	0.665862042031387	0.649260891003561	0.659287218100013	0.671699219094125	0.70021199425419	NA	NA	0.684367794215694	0.660024864968648	NA	NA	p.Tyr13Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.744	-3.763	2.019	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13L	13	Y	L	missense	possibly_wt-like	0.842858972782537	0.213713032444026	6	0.0872479801451219	0.671856073974232	1.01386187159084	1.07329252487871	1.0041164493426	0.741851770835687	0.485454605420316	NA	NA	0.808778329796987	0.943660156420922	0.663265466899436	0.701890401378901	0.674429408479386	0.640494394230597	0.553916806342232	NA	NA	0.652101525319485	0.683888918532364	NA	NA	p.Tyr13Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.744	-2.594	0.85	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13M	13	Y	M	missense	wt-like	1.13311158623599	0.183951164210709	6	0.0750977483178592	0.985922704212928	1.28030046825904	0.872367689103734	1.18388604000645	1.23135095045694	0.943521535734839	NA	NA	1.34554728876991	1.22199601334405	0.72989238686494	0.659093658525535	0.713297709789303	0.786959892704595	0.705630347537027	NA	NA	0.762517623970183	0.746487063940578	NA	NA	p.Tyr13Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.744	-3.377	1.633	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13N	13	Y	N	missense	wt-like	1.08925218857613	0.0781329865556661	6	0.0318976581901867	1.02673392733219	1.15177044982006	1.13993035910253	1.04853271641789	0.951542779648807	1.15917832376018	NA	NA	1.13781236561909	1.09851658690825	0.717400268306548	0.71608417809437	0.684032728180839	0.703237090051033	0.777056710866846	NA	NA	0.719785496144265	0.718716358518726	NA	NA	p.Tyr13Asn	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.744	-3.923	2.179	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13P	13	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr13Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.744	-4.18	2.436	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13Q	13	Y	Q	missense	possibly_wt-like	0.7862097769883	0.190215099011518	6	0.0776549889918665	0.634008795344387	0.938410758632213	0.633600165848896	1.02937450385915	0.909368599792694	0.924670536151004	NA	NA	0.577433321838114	0.642811534439942	0.648059058073225	0.608236469790955	0.67989049714197	0.690617942701007	0.699386823473936	NA	NA	0.604512683241115	0.61622761900448	NA	NA	p.Tyr13Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.744	-4.118	2.374	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13R	13	Y	R	missense	wt-like	0.817195937719568	0.102844054463662	6	0.0419859094191623	0.734905067399849	0.899486808039287	0.878557669079904	0.923605051508887	0.831592752566439	0.885127442521024	NA	NA	0.662995177119629	0.721297533521524	0.65871700666508	0.660412116645886	0.657021896684275	0.667346242343827	0.686289997732155	NA	NA	0.622113191049125	0.633879236145475	NA	NA	p.Tyr13Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.744	-3.143	1.399	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13S	13	Y	S	missense	wt-like	1.07938880684589	0.0660303215806132	6	0.0269567659040644	1.02655451653425	1.13222309715753	1.14463550759547	1.04685223757717	1.13704905666451	1.12575022644798	NA	NA	0.982192555927642	1.03985325686258	0.711304628931666	0.71708636893535	0.683669388876983	0.758743351275379	0.765985195585977	NA	NA	0.6877737116108	0.705522888927982	NA	NA	p.Tyr13Ser	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.744	-2.733	0.989	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13T	13	Y	T	missense	wt-like	1.07759814320914	0.109286928356499	6	0.0446162016715875	0.99015199480585	1.16504429161242	1.09960752380716	1.00123580520837	1.01899174046855	1.22630735704752	NA	NA	0.943073361439909	1.17637307128332	0.715457147420512	0.707495463779393	0.673806579313661	0.723418831061631	0.799290106650324	NA	NA	0.679726694797536	0.736226396872243	NA	NA	p.Tyr13Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.744	-3.679	1.935	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13V	13	Y	V	missense	wt-like	0.976758636990752	0.111884400628905	6	0.0456766152863245	0.887234116093865	1.06628315788764	0.958530802572296	1.11501032509362	0.8678812036377	1.03239492260703	NA	NA	1.05730839958107	0.829426168452799	0.688305130463326	0.677446295701206	0.698405969588516	0.678204291338136	0.735065557433312	NA	NA	0.703225421819486	0.6581975258802	NA	NA	p.Tyr13Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.744	-2.897	1.153	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13W	13	Y	W	missense	wt-like	0.963199681628066	0.0934195077730276	6	0.0381383543443141	0.888449880683584	1.03794948257255	1.02642715551203	0.822180913218474	0.878087094038393	0.96967782631938	NA	NA	1.05216873637642	1.0306563643037	0.697038151186247	0.691908135355003	0.63509280426874	0.681258046864479	0.714293412269459	NA	NA	0.702168167017491	0.703454494204899	NA	NA	p.Tyr13Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.744	-4.946	3.202	0.001428615	NA	NA	NA	NA	NA	NA	NA
Y13X	13	Y	X	nonsense	low	0.421206313872387	0.128400666159122	6	0.0524193524538829	0.318466270969865	0.523946356774909	0.368425654115874	0.527628841141533	0.497403553414433	0.519699143924429	NA	NA	0.422685296265676	0.191395394372379	0.566305275120762	0.551754624994949	0.571407179538389	0.567351820133973	0.56525873010755	NA	NA	0.572680229124727	0.514703462225181	NA	NA	p.Tyr13Ter	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Y13Y	13	Y	Y	synonymous	wt-like	1.11699450950863	0.130379648119101	6	0.0532272684559029	1.01267098033962	1.22131803867765	0.977507830476696	1.05481139702025	1.22484529566066	1.19757384032194	NA	NA	0.976205858236261	1.27102283533599	0.72202774307534	0.681488379300345	0.685390252824357	0.785013303185541	0.789773454639613	NA	NA	0.686542217516677	0.757513268634002	NA	NA	p.Tyr13=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-1.3	-1.3	0	255	255	0	6.2	6.2	0	181	181	0	5.66	5.66	0	NA	NA	NA	0.001428615	NA	NA	NA	NA	NA	NA	NA
S14A	14	S	A	missense	possibly_wt-like	0.849741321113321	0.413446032627367	6	0.168788636019189	0.518921673516071	1.18056096871057	0.436794310699372	0.299317614802759	0.989429339126741	0.945807991526302	NA	NA	1.42300401978765	1.0040946507371	0.701934178066802	0.566317064743866	0.52204360528202	0.714573317056958	0.706387630549512	NA	NA	0.778450866588349	0.697480725584091	NA	NA	p.Ser14Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.883	-2.395	0.512	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14C	14	S	C	missense	wt-like	1.21682596855001	0.223346057320568	6	0.0911806460829658	1.03811518614031	1.39553675095972	0.810766649155883	1.17702467560178	1.33770552823781	1.47312275526512	NA	NA	1.26321629207705	1.23911991096244	0.747959986990357	0.64597271279486	0.711814202049796	0.818782778008959	0.881036322338247	NA	NA	0.745581720168585	0.750338253812128	NA	NA	p.Ser14Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.883	-5.06	3.177	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14D	14	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser14Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.883	-2.742	0.859	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14E	14	S	E	missense	possibly_wt-like	0.778223392843833	0.22373893088658	6	0.0913410360446586	0.599198251885728	0.957248533801939	0.595530770205049	1.02602419217111	0.803254526034488	0.451108847086995	NA	NA	0.797200708368008	0.996221313197349	0.654293484825175	0.600127735349696	0.679166120323332	0.658867019808495	0.542541358177505	NA	NA	0.649719949841856	0.695710000340101	NA	NA	p.Ser14Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.883	-3.549	1.666	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14F	14	S	F	missense	possibly_low	0.648843761385559	0.580385643991479	5	0.259556350625988	0.140122662199972	1.15756486057114	1.11250046091459	1.36107117513909	NA	0.313616047820324	NA	NA	-0.0538099137232029	0.510841036776991	0.586547259119762	0.710241643523092	0.751607221395477	NA	0.497003210616385	NA	NA	0.474662746494231	0.586547259119762	NA	NA	p.Ser14Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.883	-2.788	0.905	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14G	14	S	G	missense	wt-like	1.06960945757786	0.0379954253389999	6	0.015511567440094	1.03920734405151	1.10001157110421	1.07543108668921	1.09242789269673	1.12399844658039	1.03161188990508	NA	NA	1.07207165273356	1.02211577686217	0.704304105160831	0.702345912413796	0.693523381919091	0.754838412940571	0.734806213970115	NA	NA	0.706262297907866	0.701533703472271	NA	NA	p.Ser14Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.883	-2.42	0.537	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14H	14	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser14His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.883	-3.412	1.529	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14I	14	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser14Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.883	-4.031	2.148	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14K	14	S	K	missense	wt-like	1.10999276046164	0.102802746137801	6	0.0419690453657478	1.02773494307924	1.19225057784403	1.07731072973462	0.972890605302371	1.10764024618575	1.23710869903283	NA	NA	1.04362267001557	1.22138361249866	0.724547804077993	0.702746274070236	0.667678013483547	0.749943793961246	0.802867552944303	NA	NA	0.700410197800751	0.74634933408575	NA	NA	p.Ser14Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.883	-3.654	1.771	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14L	14	S	L	missense	wt-like	0.949867560020287	0.104071378392872	6	0.0424869623151078	0.866594644070165	1.03314047597041	1.02696289053304	1.08815480559419	0.827345473489196	0.966500527889473	NA	NA	0.832652916302717	0.95758874631311	0.689521862615651	0.692022246255446	0.69259949019518	0.666075392722204	0.713241078725313	NA	NA	0.657012648913341	0.687021478975856	NA	NA	p.Ser14Leu	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.883	-3.606	1.723	0.002281122	NA	NA	NA	NA	2.44e-05	NA	NA
S14M	14	S	M	missense	possibly_wt-like	0.822969718867884	0.22777818376412	6	0.0929900541266656	0.640712561859189	1.00522687587658	0.798907111805781	0.961808043025774	0.996636952855412	1.05357391884027	NA	NA	0.667166531802261	0.459725754877809	0.654364239505371	0.643446645928241	0.665281833082501	0.716729943220039	0.742080123001906	NA	NA	0.622971259874539	0.575051356707912	NA	NA	p.Ser14Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.883	-4.8	2.917	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14N	14	S	N	missense	wt-like	1.31466435483515	0.411003257892622	6	0.167791377409741	0.985799298195692	1.64352941147461	1.05522316746643	0.785169519472573	1.30778145730325	1.14443744495928	NA	NA	1.82315324253431	1.77222129727506	0.791001760879812	0.698041650478017	0.627090505333179	0.809829047036024	0.7721744747236	NA	NA	0.860763592231682	0.870233543145743	NA	NA	p.Ser14Asn	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.883	-3.025	1.142	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14P	14	S	P	missense	low	-0.0134107663779522	0.268468448270983	2	0.189835860307042	-0.385482215553932	0.358660682798027	NA	NA	NA	-0.203246626684994	NA	NA	NA	0.17642509392909	0.418576455398783	NA	NA	NA	0.32581629125774	NA	NA	NA	0.511336619539826	NA	NA	p.Ser14Pro	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.883	-2.131	0.248	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14Q	14	S	Q	missense	possibly_low	0.571853566743503	0.219320924175998	6	0.0895373923578058	0.396363502452572	0.747343631034435	0.593680901215925	0.901524984613893	0.39600927800158	0.741023431192377	NA	NA	0.478045146547839	0.320837658889407	0.591900873388699	0.59973371553062	0.652247926348978	0.537013131717285	0.63856219113404	NA	NA	0.584068031246778	0.543815218740416	NA	NA	p.Ser14Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.883	-3.21	1.327	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14R	14	S	R	missense	wt-like	1.23201478323819	0.172223684329941	6	0.0703100247050863	1.0942096670641	1.36981989941228	0.998030635943248	1.02621096317318	1.30273500277487	1.34107948517172	NA	NA	1.37788991772969	1.34614269463643	0.771789251416318	0.685859711618692	0.679206502412192	0.808319072129432	0.83730307994274	NA	NA	0.769170666867223	0.774407835965414	NA	NA	p.Ser14Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.883	-4.001	2.118	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14S	14	S	S	synonymous	possibly_wt-like	1.1702747594412	0.685856062588958	4	0.342928031294479	0.498148168814793	1.8424013500676	0.236797043341778	1.08475485423031	1.59815482528062	NA	NA	NA	NA	1.76139231491208	0.779831234854508	0.523717892822358	0.691864380694389	0.896713115191735	NA	NA	NA	NA	0.867798089014628	NA	NA	p.Ser14=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14T	14	S	T	missense	possibly_wt-like	0.808773677032367	0.164850013899592	6	0.0672997363574526	0.676868617602719	0.940678736462015	0.835880768472631	0.502572280581684	0.775124992595792	0.913406872469416	NA	NA	0.850988606841079	0.9746685412336	0.656053191407677	0.651321989315317	0.565989656240739	0.650450241377676	0.6956562544438	NA	NA	0.660784393500037	0.690862750085494	NA	NA	p.Ser14Thr	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.883	-2.395	0.512	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14V	14	S	V	missense	wt-like	0.833016289616132	0.0886761351030731	6	0.0362018805607721	0.762061907544398	0.903970671687866	0.705624386087459	0.92213703458239	0.792654201381652	0.942091996081405	NA	NA	0.841837738846639	0.793752380717248	0.656199868891546	0.623577540101526	0.656704494146858	0.655695243636234	0.705156878467885	NA	NA	0.658902013518253	0.650174438317506	NA	NA	p.Ser14Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.883	-3.683	1.8	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14W	14	S	W	missense	possibly_wt-like	0.813616907057996	0.235286718165335	6	0.0960554004598509	0.625351781636117	1.00188203247988	0.774898232819596	0.936629395976853	1.05867513695406	0.882753028493319	NA	NA	0.855140598066408	0.373605050037748	0.660738196206518	0.638332784238588	0.65983791324901	0.735292698658077	0.685503582611207	NA	NA	0.661638479164025	0.555682682963067	NA	NA	p.Ser14Trp	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.883	-5.422	3.539	0.002281122	NA	NA	NA	NA	NA	NA	NA
S14X	14	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser14Ter	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S14Y	14	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser14Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.883	-4.219	2.336	0.002281122	NA	NA	NA	NA	NA	NA	NA
D15A	15	D	A	missense	wt-like	0.921960129825061	0.0959671379595708	6	0.0391784200127045	0.845171837628977	0.998748422021145	1.04191759111905	0.928643649657018	0.88430845943779	0.920301923929413	NA	NA	0.993142818611274	0.763446336195819	0.686572904470919	0.695207579083815	0.658111300905967	0.683119572730807	0.697939922188595	NA	NA	0.690026236211031	0.643358564133447	NA	NA	p.Asp15Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.729	-3.313	1.584	0.002282319	NA	NA	NA	NA	4.06e-06	NA	NA
D15C	15	D	C	missense	possibly_wt-like	0.776688954527	0.243993017502951	6	0.0996097322806991	0.581457466747153	0.971920442306847	0.794859362377571	1.17853527183497	0.57834868291705	0.931461755578085	NA	NA	0.61763479657302	0.55929385788131	0.627683405436258	0.642584480279351	0.712140810734459	0.591571817296821	0.701636101647337	NA	NA	0.612782330593165	0.597444370165587	NA	NA	p.Asp15Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.729	-3.571	1.842	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15E	15	D	E	missense	possibly_wt-like	0.79479157684663	0.276962197073131	6	0.113069343478221	0.573179735873727	1.01640341781953	1.07952705067445	1.19863586983262	0.589077683028535	0.746488777657039	NA	NA	0.589796026418032	0.565224053469099	0.623714044677274	0.703218347704022	0.71648679659668	0.594782095096821	0.640372335047815	NA	NA	0.607055754306733	0.598778079913973	NA	NA	p.Asp15Glu	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.729	-2.432	0.703	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15F	15	D	F	missense	possibly_wt-like	0.882733922117664	0.320344517188877	6	0.130780101501831	0.626409633279583	1.13905821095574	0.926989723273105	0.747739176434595	1.0350118517361	1.41248105175356	NA	NA	0.50256078955538	0.671620939953238	0.646717490737602	0.670728084610583	0.618997624629823	0.728212288701799	0.86095155529884	NA	NA	0.589111023416045	0.622706896864621	NA	NA	p.Asp15Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.729	-4.374	2.645	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15G	15	D	G	missense	wt-like	0.861082835204773	0.10135651843327	6	0.0413786253777516	0.779982219734605	0.942183450674941	0.97776655788753	0.99063253703974	0.801201930691981	0.852249044784126	NA	NA	0.800137985551839	0.744508955273422	0.664883440213435	0.681543487920581	0.671514027939838	0.658252852487033	0.67540054507935	NA	NA	0.650324162663542	0.639099519187763	NA	NA	p.Asp15Gly	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.729	-2.521	0.792	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15H	15	D	H	missense	wt-like	1.46245393654667	0.0825721421332648	4	0.0412860710666324	1.38153472419291	1.54337314890043	NA	NA	1.52121497642564	1.431206727084	NA	NA	1.36024725415262	1.53714678852441	0.842259255167748	NA	NA	0.873691558089683	0.867153571483886	NA	NA	0.765541481443174	0.817364938851609	NA	NA	p.Asp15His	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.729	-4.745	3.016	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15I	15	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp15Ile	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.729	-2.953	1.224	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15K	15	D	K	missense	wt-like	0.857555022792468	0.0777195643705822	6	0.0317288792898863	0.795367562114472	0.919742483470464	0.832221171351565	0.900092942781473	0.911791645693474	0.770126653497111	NA	NA	0.957845234399289	0.773252489031895	0.651240400840338	0.650542499630365	0.651938302050311	0.691342954387355	0.648201291064259	NA	NA	0.682765344023935	0.645563982392933	NA	NA	p.Asp15Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.729	-2.653	0.924	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15L	15	D	L	missense	wt-like	1.0247398147891	0.174305008289081	6	0.0711597216533069	0.885269323198727	1.16421030637948	0.787062081847618	0.819966647653956	1.18332805346924	1.14068056428907	NA	NA	1.08873763259796	1.12866390887677	0.717593555151137	0.640923669118257	0.634614053992767	0.772590721440792	0.770930181297019	NA	NA	0.70969057453612	0.725496535766155	NA	NA	p.Asp15Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.729	-3.521	1.792	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15M	15	D	M	missense	wt-like	1.07143878680208	0.150778090137664	6	0.0615548975381077	0.950793404555332	1.19208416904882	1.16866998907727	1.08220358858084	1.12101287706588	1.22524209493034	NA	NA	0.794280630531995	1.03722354062613	0.713568572893297	0.722205683925074	0.691312767033708	0.753945085749481	0.798937287711861	NA	NA	0.649119275013293	0.704931461861519	NA	NA	p.Asp15Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.729	-3.235	1.506	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15N	15	D	N	missense	possibly_wt-like	0.811426470669298	0.18628250206842	6	0.0760495130127636	0.662372164122471	0.960480777216125	0.730483519298131	1.02693793407021	0.869296813989216	0.637517448871091	NA	NA	0.593902221826577	1.01042088596056	0.653750184044349	0.628872504895059	0.679363682076255	0.67862786319364	0.604280608959955	NA	NA	0.607900419538821	0.698903505231609	NA	NA	p.Asp15Asn	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.729	-2.518	0.789	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15P	15	D	P	missense	possibly_wt-like	1.01875633631262	0.373210910202358	6	0.152362716072575	0.72013090022367	1.31738177240157	0.574656671698729	0.558238399883461	1.16298530780102	1.0533110207675	NA	NA	1.35237181382127	1.41097480390373	0.752957256772934	0.59568157804602	0.578025326399331	0.766503866735681	0.741993050142129	NA	NA	0.76392146340374	0.788988673116254	NA	NA	p.Asp15Pro	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.729	-4.033	2.304	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15Q	15	D	Q	missense	wt-like	1.24748867723496	0.167745783345263	5	0.0750181948997922	1.10045571704616	1.39452163742376	1.35915576744244	0.970283837954145	1.29566547497681	1.22239944156367	NA	NA	1.38993886423774	NA	0.771649196305319	0.762778920391706	0.667114399702364	0.806203763348485	0.797995789908582	NA	NA	0.771649196305319	NA	NA	NA	p.Asp15Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.729	-3.984	2.255	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15R	15	D	R	missense	wt-like	1.01090644263669	0.118573653922202	6	0.0484074915077925	0.916029502699492	1.1057833825739	1.01215536578656	1.0971223593353	0.858812996493096	0.873224973578895	NA	NA	1.09960101594195	1.12452194468436	0.691703321278995	0.68886826169985	0.694538380858141	0.67549094771062	0.68234785392594	NA	NA	0.711925227615324	0.724565001900349	NA	NA	p.Asp15Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.729	-3.983	2.254	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15S	15	D	S	missense	wt-like	1.10702820224984	0.158259048874817	6	0.0646089861535812	0.980396916311173	1.23365948818851	1.06294691375424	0.832156350316413	1.23325775752933	1.06520897925274	NA	NA	1.25996489272516	1.18863431992116	0.741948430313703	0.699686798935992	0.637249611175787	0.787530437988384	0.745933700067554	NA	NA	0.744912890822943	0.738983969804463	NA	NA	p.Asp15Ser	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.729	-2.591	0.862	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15T	15	D	T	missense	wt-like	1.09669193143748	0.0500776924701085	6	0.0204441323412968	1.05662216835336	1.13676169452159	1.07290005946205	1.0448567110841	1.1085525546055	1.04994699962664	NA	NA	1.17260901220374	1.13128625164283	0.726514823723843	0.701806806727942	0.68323793256272	0.750216770327751	0.740878873313025	NA	NA	0.726943342919452	0.726086304528233	NA	NA	p.Asp15Thr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.729	-3.001	1.272	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15V	15	D	V	missense	wt-like	0.974405287661486	0.0459814991749668	6	0.0187718684311457	0.937613101613916	1.01119747370906	0.937719456467783	0.986730964922936	1.01445667989283	1.01947287502194	NA	NA	0.901642506020138	0.986409243643287	0.68325837799196	0.67301350458192	0.67067046212841	0.722061872898095	0.730785725232207	NA	NA	0.671204157600218	0.693503251401999	NA	NA	p.Asp15Val	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.729	-2.653	0.924	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15W	15	D	W	missense	possibly_wt-like	0.723144843284804	0.274881332839929	6	0.112219834212329	0.503198009877583	0.943091676692024	0.905060782756228	1.1764394844109	0.651411650436525	0.672488449945817	NA	NA	0.463206760815738	0.470261931343615	0.61464824664027	0.666057247256267	0.711687676826886	0.613433353338637	0.615863139941903	NA	NA	0.581015700005516	0.577420958360189	NA	NA	p.Asp15Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.729	-5.589	3.86	0.002282319	NA	NA	NA	NA	NA	NA	NA
D15X	15	D	X	nonsense	possibly_wt-like	0.759701685594314	0.124595499075227	6	0.0508658994969532	0.660006354539052	0.859397016649576	0.847217724717032	0.838971785857472	0.881468745059014	0.675577616011066	NA	NA	0.55531648978628	0.759657752135019	0.640614847267854	0.653736747049273	0.638723188554419	0.682269887584587	0.616886283705579	NA	NA	0.599963138658006	0.642506505981289	NA	NA	p.Asp15Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D15Y	15	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp15Tyr	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.729	-4.45	2.721	0.002282319	1.107028754	0.0449999997830672	NA	NA	1.63e-05	NA	NA
T16A	16	T	A	missense	wt-like	1.02492967978079	0.0670296290806991	6	0.0273647314826223	0.971295791628239	1.07856356793334	0.967420055558291	1.00470455864178	1.08693361566299	1.11228267908457	NA	NA	1.03763940452519	0.940597765211917	0.691189795976586	0.679339695652152	0.674556564631654	0.74374805944831	0.76152469174583	NA	NA	0.699179409727791	0.683200182225382	NA	NA	p.Thr16Ala	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.192	-2.302	0.11	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16C	16	T	C	missense	low	0.19945082004389	0.0625380790452068	2	0.0442210997752461	0.112779057127655	0.286122582960124	NA	NA	0.243671919819136	0.155229720268643	NA	NA	NA	NA	0.46798827710803	NA	NA	0.491431508639454	0.444545045576606	NA	NA	NA	NA	NA	NA	p.Thr16Cys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.192	-5.052	2.86	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16D	16	T	D	missense	possibly_wt-like	0.725586822604969	0.231249033859061	6	0.0944070227443815	0.540552458138328	0.91062118707161	0.691731278480557	1.01485609347617	0.395808687146604	0.60569556594451	NA	NA	0.965126918721573	0.680302391860404	0.622638846747733	0.620618325271795	0.676751445941914	0.536953111924022	0.593741078103705	NA	NA	0.684263223439338	0.624659368223672	NA	NA	p.Thr16Asp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.192	-3.831	1.639	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16E	16	T	E	missense	wt-like	1.09564621641712	0.18312833556157	6	0.0747618299285038	0.949115722338942	1.24217671049529	0.869324122785006	1.16990431681906	1.31624547348087	1.2252860578044	NA	NA	1.11021774621936	0.882899581394017	0.712191919792309	0.658445382643674	0.710274696677506	0.812361607661571	0.798951848385998	NA	NA	0.714109142907112	0.670223775447076	NA	NA	p.Thr16Glu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.192	-3.14	0.948	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16F	16	T	F	missense	wt-like	1.10786506387162	0.0886920166542	6	0.0362083641768696	1.03689797414584	1.17883215359739	1.18701374837335	1.09818399612669	1.06396801851654	1.04480306148007	NA	NA	1.2414292476644	1.01179231106866	0.731494645160029	0.726112882089653	0.694767919227433	0.736876408230404	0.739175181078865	NA	NA	0.741100014576339	0.69921194076443	NA	NA	p.Thr16Phe	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.192	-4.285	2.093	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16G	16	T	G	missense	wt-like	1.0634467665072	0.132845094634639	6	0.0542337827811015	0.957150505510874	1.16974302750353	0.820316482995258	1.05108001304997	1.05027262547259	1.09885451886653	NA	NA	1.19312923984231	1.16702771881654	0.731971499516642	0.648006815654966	0.684583483693247	0.73277854116037	0.757077233080761	NA	NA	0.731164457872914	0.734124613296555	NA	NA	p.Thr16Gly	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.192	-2.795	0.603	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16H	16	T	H	missense	possibly_low	0.688001027754943	0.349891905110254	6	0.142842772108405	0.408034338970606	0.967967716539279	1.211352465599	1.02528047484686	0.425579773931385	0.351960847143869	NA	NA	0.621388178360362	0.492444426648184	0.597982127298743	0.731296998918562	0.679005319884605	0.545861067744131	0.509703156643452	NA	NA	0.613554420273049	0.582409834324438	NA	NA	p.Thr16His	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.192	-4.88	2.688	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16I	16	T	I	missense	wt-like	0.908707702667828	0.176287592162948	6	0.0719691081305141	0.767650842732552	1.0497645626031	0.725591302796327	0.896977464126886	0.843896584659565	1.14713880061516	NA	NA	0.745478852968996	1.09316321084003	0.661146216198623	0.627830468798311	0.651264698897387	0.671027733499858	0.773069174177889	NA	NA	0.639080501727975	0.717512376332428	NA	NA	p.Thr16Ile	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.192	-2.784	0.592	0.001895448	NA	NA	NA	NA	4.06e-06	NA	NA
T16K	16	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr16Lys	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.192	-3.734	1.542	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16L	16	T	L	missense	wt-like	1.03348610764468	0.081598866547511	6	0.0333125977718103	0.968194615780462	1.0987775995089	0.935145493185743	1.06252822265047	0.978945344873103	1.12346802426294	NA	NA	0.97580595333857	1.12502360755726	0.699247535017331	0.672465253569194	0.687058721349226	0.711436348685436	0.765229321384411	NA	NA	0.686459955049938	0.72467782662157	NA	NA	p.Thr16Leu	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.192	-2.606	0.414	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16M	16	T	M	missense	wt-like	1.13420383559077	0.0689065056586885	6	0.0281309631369981	1.07906816099183	1.18933951018971	1.16967096261038	1.12606320684173	1.08210754116475	1.25520016992863	NA	NA	1.10079491166681	1.07138622133234	0.717516794638617	0.722418890056283	0.700795732709977	0.742304025553085	0.808859518164623	NA	NA	0.712170818024253	0.712614699220952	NA	NA	p.Thr16Met	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.192	-3.288	1.096	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16N	16	T	N	missense	wt-like	0.927696231753737	0.136823192695848	6	0.0558578345138876	0.818216887852119	1.03717557565535	0.936958325725958	1.16397079481669	0.84028372450509	0.756109217505463	NA	NA	0.950518041857673	0.918337286111547	0.675522576130232	0.672851384670213	0.708991799385669	0.669946711538082	0.643558661980985	NA	NA	0.681258103336889	0.678193767590251	NA	NA	p.Thr16Asn	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.192	-2.673	0.481	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16P	16	T	P	missense	possibly_low	0.557905105964368	0.416013126902132	6	0.169836647868321	0.225031392887447	0.890778819041289	0.917843261137799	1.15844088039193	0.36357350364669	0.542295585586653	NA	NA	0.3491886063706	0.0160887986525372	0.565152173075855	0.668779899427238	0.707796166802395	0.527307861398028	0.572742759091314	NA	NA	0.557561587060397	0.475276749866951	NA	NA	p.Thr16Pro	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.192	-2.833	0.641	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16Q	16	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr16Gln	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.192	-3.362	1.17	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16R	16	T	R	missense	wt-like	0.994754236992301	0.127668511756448	6	0.0521204516706353	0.892600028859895	1.09690844512471	0.896451288179025	0.957452823218885	1.02934715111621	1.14943011872742	NA	NA	1.11604383755115	0.819800203161115	0.689823891379664	0.66422343550225	0.664340183301245	0.726517325289112	0.773828067609851	NA	NA	0.715307599458083	0.65603263206564	NA	NA	p.Thr16Arg	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.192	-3.312	1.12	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16S	16	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr16Ser	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.192	-2.55	0.358	0.001895448	NA	NA	NA	NA	1.08e-05	NA	NA
T16T	16	T	T	synonymous	wt-like	0.873244662695433	0.173195483953697	6	0.0707067602401584	0.734661959161214	1.01182736622965	0.694725805257692	1.1417414430542	0.917298041309078	0.941259406401347	NA	NA	0.674636121019954	0.869807159130329	0.680134910453112	0.621256155791622	0.704185551905002	0.692990550567717	0.704881121541627	NA	NA	0.624507792280435	0.667279270338507	NA	NA	p.Thr16=	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16V	16	T	V	missense	wt-like	0.861941708266705	0.147389048143847	6	0.0601713269378217	0.74400807456659	0.97987534196682	0.727013256646694	0.700101751924259	0.77128371645599	0.974527407144144	NA	NA	0.946652085593031	1.05207203183611	0.664881865220976	0.628133343219229	0.608697852779319	0.649300873926177	0.715899612218733	NA	NA	0.680462856515774	0.708270909470354	NA	NA	p.Thr16Val	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.192	-2.391	0.199	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16W	16	T	W	missense	wt-like	1.17850849295334	0.191047808589561	6	0.0779949412535557	1.02564121712006	1.33137576878663	1.01283403368755	1.09876193158701	1.35834171544707	1.41628177267506	NA	NA	1.24239699238102	0.942434511942355	0.718095980125643	0.689012817127901	0.694892875675998	0.824957434825637	0.86221036878642	NA	NA	0.741299084575289	0.683613269278487	NA	NA	p.Thr16Trp	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.192	-3.709	1.517	0.001895448	NA	NA	NA	NA	NA	NA	NA
T16X	16	T	X	nonsense	possibly_low	0.675083498214091	0.184482679662412	6	0.075314738592372	0.527469323067993	0.822697673360189	0.710314516400644	1.00160701714209	0.480603146079393	0.71447237395751	NA	NA	0.59987278922214	0.543631146482769	0.616852563818968	0.624576532088694	0.673886839702732	0.562324886203671	0.629768378158278	NA	NA	0.609128595549242	0.593921803233496	NA	NA	p.Thr16Ter	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T16Y	16	T	Y	missense	possibly_wt-like	0.816691199211462	0.131731292443921	6	0.0537790749408261	0.711286149205562	0.922096249217361	0.800868920268483	1.00993726963573	0.711937914129086	0.640026361427854	NA	NA	0.840580068311636	0.896796661495984	0.651253906512372	0.643864508717487	0.675687938335235	0.63154371950791	0.605111570514576	NA	NA	0.658643304307257	0.673349249292197	NA	NA	p.Thr16Tyr	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.192	-4.367	2.175	0.001895448	NA	NA	NA	NA	NA	NA	NA
E17A	17	E	A	missense	wt-like	0.957869558931649	0.120884413098267	6	0.049350854991095	0.861143660542844	1.05459545732045	0.753801394246329	0.918019079785079	1.03601227122997	0.915543396842429	NA	NA	1.05003990802192	1.07380130346417	0.699047067906142	0.633839183574655	0.655814143853177	0.728511629223608	0.696363879589881	NA	NA	0.701730256222404	0.713157854760207	NA	NA	p.Glu17Ala	1	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.549	-2.627	1.078	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17C	17	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu17Cys	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.549	-5.304	3.755	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17D	17	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu17Asp	1	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.549	-2.876	1.327	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17F	17	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu17Phe	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.549	-4.47	2.921	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17G	17	E	G	missense	wt-like	1.21042560336447	0.132362662925774	6	0.0540368308606919	1.10451536103883	1.31633584569011	1.20270888105863	0.965849926312817	1.19883366784906	1.30716461296131	NA	NA	1.24784106587078	1.34015546613422	0.757740128773977	0.729455926044327	0.666155735820334	0.777230233893181	0.826070342930537	NA	NA	0.742418958117634	0.773061299430321	NA	NA	p.Glu17Gly	1	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.549	-2.199	0.65	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17H	17	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu17His	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.549	-3.419	1.87	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17I	17	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu17Ile	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.549	-4.189	2.64	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17K	17	E	K	missense	possibly_wt-like	0.829228833363672	0.166718661076684	6	0.0680626083729806	0.695828572258775	0.962629094468568	0.873191365113332	1.05195817838211	0.540601394172506	0.790337759788537	NA	NA	0.879215607170625	0.84006869555492	0.659930073225018	0.659269100502338	0.684773353373672	0.580277262183798	0.654895287735949	NA	NA	0.666590830703418	0.660591045947697	NA	NA	p.Glu17Lys	1	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.549	-2.411	0.862	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17L	17	E	L	missense	wt-like	0.944117020116386	0.133189415757053	6	0.0543743512906977	0.83754524990389	1.05068879032888	0.871188830728342	0.839864606268747	0.804878561853862	1.02985947449229	NA	NA	1.15734569723283	0.961564950122243	0.673634344388781	0.658842563141743	0.638916226835438	0.659352955690978	0.73422580719913	NA	NA	0.723803601577498	0.687915733086584	NA	NA	p.Glu17Leu	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.549	-3.698	2.149	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17M	17	E	M	missense	wt-like	1.01492824397809	0.0677487488650855	6	0.0276583109052367	0.960718950730612	1.06913753722556	0.919487177203523	1.00730698624487	1.12121368129955	1.05402953790677	NA	NA	0.999297812061963	0.988234269151851	0.692603025965918	0.669130051526982	0.675119240108863	0.754005169388851	0.742231025801127	NA	NA	0.691292349596846	0.69391370233499	NA	NA	p.Glu17Met	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.549	-3.537	1.988	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17N	17	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu17Asn	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.549	-3.046	1.497	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17P	17	E	P	missense	possibly_wt-like	0.759168812074331	0.160209265849823	6	0.0654051588996609	0.630977056227876	0.887360567920785	0.984220006439926	0.837596651896209	0.782428098140527	0.68381889632349	NA	NA	0.763319534685196	0.503629684960635	0.640588144447674	0.682918064523563	0.638425868407277	0.652635440124782	0.6196158276596	NA	NA	0.64275042048807	0.584925415442917	NA	NA	p.Glu17Pro	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.549	-3.134	1.585	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17Q	17	E	Q	missense	wt-like	1.04911629711183	0.214555778199878	6	0.0875920296592441	0.877439073646945	1.22079352057671	1.0287977454505	0.885006115510931	0.855621307043393	0.895005526219504	NA	NA	1.30788364284742	1.32238344559922	0.690987362700962	0.692413068095727	0.648676352429151	0.674535946342514	0.689561657306196	NA	NA	0.754770020882852	0.769064345757351	NA	NA	p.Glu17Gln	1	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.549	-3.1	1.551	0.001923936	0.805111821	0.106926766345816	NA	NA	3.66e-05	NA	NA
E17R	17	E	R	missense	wt-like	0.931035856234051	0.0621117814011464	6	0.0253570285746832	0.881336993472719	0.980734718995384	0.848207213504687	0.919915557817085	0.970752899848635	0.91721965543115	NA	NA	1.02917511049837	0.900944700304386	0.685600606136964	0.653947506943829	0.656224184724402	0.708985046223279	0.696919062925815	NA	NA	0.697438261495109	0.674282149348114	NA	NA	p.Glu17Arg	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.549	-2.868	1.319	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17S	17	E	S	missense	possibly_wt-like	0.907135925974166	0.255643248663647	6	0.104365919235562	0.702582483059048	1.11168936888928	1.34224218173354	0.815420181432809	0.837728739838099	1.06961089972195	NA	NA	0.724786599917695	0.653026953200903	0.652003111033799	0.759176347441875	0.633631054485863	0.669182221793413	0.747391633173494	NA	NA	0.634824000274184	0.618525081775081	NA	NA	p.Glu17Ser	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.549	-2.902	1.353	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17T	17	E	T	missense	possibly_wt-like	0.758243264905874	0.262223475427949	6	0.107052285562953	0.548424640739788	0.968061889071959	1.02145082858495	1.04613763378633	0.712312220220683	0.657419604259449	NA	NA	0.335138717942669	0.777000584641158	0.639031326069369	0.69084818384114	0.683514883126834	0.631655717506211	0.61087227989613	NA	NA	0.554671453715767	0.646406934632526	NA	NA	p.Glu17Thr	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.549	-3.664	2.115	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17V	17	E	V	missense	wt-like	0.905767381401132	0.120522881312584	6	0.0492032602576415	0.809330763374204	1.00220399942806	0.877350998674663	0.935009307518753	1.04631569537204	1.01061421990433	NA	NA	0.853038991059732	0.71227507587728	0.660680632636134	0.660155097333949	0.659487631056646	0.731594568308663	0.72785170435191	NA	NA	0.66120616793832	0.631850072092387	NA	NA	p.Glu17Val	1	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.549	-3.775	2.226	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17W	17	E	W	missense	wt-like	0.937817249180383	0.150602523018662	6	0.0614832225619132	0.817312347305572	1.05832215105519	0.756883694702857	1.06692088141709	0.922359316791663	1.10212391350216	NA	NA	0.762700284579687	1.01591540408884	0.691256713000191	0.634495709780219	0.688008465874217	0.694504960126165	0.758160069244885	NA	NA	0.642623037599033	0.700139230475722	NA	NA	p.Glu17Trp	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.549	-5.529	3.98	0.001923936	NA	NA	NA	NA	NA	NA	NA
E17X	17	E	X	nonsense	possibly_low	0.642773335499697	0.167859804037378	6	0.0685284780358586	0.50845998663407	0.777086684365324	0.716725178438554	0.913472650842707	0.62722556121206	0.608382111422338	NA	NA	0.402450980807264	0.588383530275257	0.605091596520618	0.625941995216724	0.654831152406383	0.606196512580009	0.59463087236967	NA	NA	0.56851792775756	0.603986680461226	NA	NA	p.Glu17Ter	1	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E17Y	17	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu17Tyr	0	37.7	4.9	1.1	0	360	360	360	-36.2	88.3177570093458	-1.4	0	0	32.31	1	3	1	3	4	22.6182271471703	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.549	-4.382	2.833	0.001923936	NA	NA	NA	NA	NA	NA	NA
V18A	18	V	A	missense	wt-like	0.986684060670335	0.0746621312614585	6	0.030480687449879	0.92694301104455	1.04642511029612	1.09657548364445	1.01798802400333	0.945846782474298	0.911297631279747	NA	NA	0.914392214658984	1.0340042279612	0.69824521391668	0.706849642954586	0.677428606183321	0.701532762239664	0.694957665593697	NA	NA	0.673826837364577	0.704207433687278	NA	NA	p.Val18Ala	1	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.877	-2.196	0.319	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18C	18	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val18Cys	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.877	-5.046	3.169	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18D	18	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val18Asp	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.877	-3.926	2.049	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18E	18	V	E	missense	wt-like	1.22752482613151	0.11519356627305	6	0.0470275765034085	1.13535246990463	1.31969718235839	1.08551099436263	1.13289831103605	1.27415188178855	1.19481865419623	NA	NA	1.27113528778954	1.40663382761606	0.767611539453581	0.704492920348485	0.702273562682935	0.799766573499212	0.788860926325257	NA	NA	0.74721069777094	0.788012381136223	NA	NA	p.Val18Glu	1	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.877	-3.139	1.262	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18F	18	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val18Phe	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.877	-4.227	2.35	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18G	18	V	G	missense	wt-like	0.985501360283698	0.0703682434123905	6	0.0287277150760534	0.929196073376505	1.04180664719089	0.868231033491681	0.956896711675004	0.965059206803276	1.04261213672123	NA	NA	1.05661751330499	1.02359155970601	0.702474456110338	0.658212555968854	0.664219945440272	0.70728140784192	0.73844953831433	NA	NA	0.703083303006649	0.701865609214028	NA	NA	p.Val18Gly	1	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.877	-3.679	1.802	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18H	18	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val18His	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.877	-3.63	1.753	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18I	18	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val18Ile	1	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.877	-2.617	0.74	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18K	18	V	K	missense	possibly_low	0.396113254422178	0.44303300140837	6	0.180867465444041	0.041619536176815	0.750606972667542	0.464152196871186	1.0564665179122	-0.210952470168341	0.129422548598723	NA	NA	0.256101495133912	0.681489238185391	0.555278678380203	0.572144260844292	0.685748109441235	0.355401070448578	0.435997610380668	NA	NA	0.538413095916114	0.624926291715492	NA	NA	p.Val18Lys	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.877	-3.149	1.272	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18L	18	V	L	missense	wt-like	1.03465808798486	0.140225651622982	6	0.0572468825542636	0.922456259951306	1.14685991601841	0.921326451523785	0.879656656428689	1.1763190241138	1.23087459012396	NA	NA	0.984724817729729	1.01504698798918	0.69411926656262	0.669521814694624	0.647519736414808	0.770493514701533	0.800802791931954	NA	NA	0.688294610713243	0.699943922411997	NA	NA	p.Val18Leu	1	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.877	-2.721	0.844	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18M	18	V	M	missense	wt-like	1.03456344822568	0.321951766736658	5	0.143981207179865	0.752365467702549	1.31676142874882	1.42575003241056	1.11217321883208	0.667733870455819	NA	NA	NA	1.22420319798801	0.742956921441945	0.697792553823288	0.776963416909307	0.697792553823288	0.618317206449848	NA	NA	NA	0.737556528745732	0.638750464486241	NA	NA	p.Val18Met	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.877	-3.295	1.418	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18N	18	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val18Asn	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.877	-4.055	2.178	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18P	18	V	P	missense	possibly_wt-like	0.967754507544921	0.332410239472506	6	0.135705911997334	0.701775807540984	1.23373320754886	0.864968101096939	0.352921968964332	1.16008982556932	1.00303953556862	NA	NA	1.26572322943767	1.15978438463264	0.728919258152394	0.657517555382654	0.533633497551238	0.765637495011183	0.725342939566786	NA	NA	0.746097409904913	0.732495576738001	NA	NA	p.Val18Pro	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.877	-2.86	0.983	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18Q	18	V	Q	missense	possibly_wt-like	0.766412666341396	0.317104225350881	6	0.129457257898365	0.512681103323288	1.02014422935951	0.797010910181815	1.03802429635553	0.446322471135402	0.370293658419904	NA	NA	0.769696113203086	1.17712854875264	0.643552436180781	0.643042757314939	0.68176068408391	0.552067593949205	0.515775054732305	NA	NA	0.644062115046624	0.736396304871162	NA	NA	p.Val18Gln	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.877	-2.785	0.908	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18R	18	V	R	missense	wt-like	0.903910050428332	0.0978470408597962	6	0.0399458871579595	0.82561755026823	0.982202550588433	0.943769182222119	1.01545760494501	0.966040897689583	0.931042701849321	NA	NA	0.795430711647855	0.771719204216105	0.675591794263277	0.674302088725553	0.676881499801001	0.707575144483362	0.701497309429575	NA	NA	0.649355852534817	0.645219144372736	NA	NA	p.Val18Arg	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.877	-3.324	1.447	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18S	18	V	S	missense	wt-like	0.94153896434734	0.179377502567423	6	0.0732305587708278	0.798009706588774	1.08506822210591	0.723048725327355	0.924966262475238	0.768705248120389	0.94991080995906	NA	NA	1.18078037954612	1.10182236065588	0.682531353209375	0.627288902925159	0.65731620651605	0.648529357515535	0.707746499902699	NA	NA	0.72862423464671	0.719459831918196	NA	NA	p.Val18Ser	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.877	-2.741	0.864	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18T	18	V	T	missense	possibly_wt-like	0.926985465140779	0.259074513600922	6	0.105766727280333	0.719686488908655	1.1342844413729	0.620084968061642	0.644187359251968	1.13579087496869	1.26889819891166	NA	NA	0.955737967539251	0.937213422111453	0.682385453500031	0.605357749287924	0.596608502995954	0.758366884435556	0.813396358409734	NA	NA	0.682331868537673	0.682439038462389	NA	NA	p.Val18Thr	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.877	-2.588	0.711	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18V	18	V	V	synonymous	wt-like	0.958543399599114	0.127189746944635	6	0.0519249967546787	0.856772276062585	1.06031452313564	1.18118048621195	0.989414727302833	0.994590410896819	0.8888918601576	NA	NA	0.844333294787829	0.852849618237653	0.67939375528641	0.724870404425034	0.671250723141638	0.716117587161863	0.687536787431182	NA	NA	0.659415362038849	0.66346549434033	NA	NA	p.Val18=	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18W	18	V	W	missense	wt-like	0.897599067901061	0.0526678213823242	6	0.0215015480417899	0.855456808127295	0.939741327674827	0.941885210715761	0.834184122911754	0.969785071757313	0.848908999820171	NA	NA	0.883256110861014	0.907574891340354	0.674097557182573	0.673900805112257	0.637688039476885	0.70869545753808	0.674294309252888	NA	NA	0.667421982815735	0.675773289106899	NA	NA	p.Val18Trp	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.877	-5.506	3.629	0.002327618	NA	NA	NA	NA	NA	NA	NA
V18X	18	V	X	nonsense	possibly_low	0.640131895927821	0.218447187212204	6	0.0891806907360219	0.465340953968813	0.814922837886829	0.668513712845157	1.07017031724932	0.522763960141763	0.512825339778336	NA	NA	0.537226581200729	0.529291464351622	0.59346937010218	0.615673012352429	0.688711032145564	0.574940034307684	0.562982099555401	NA	NA	0.596241952666204	0.590696787538155	NA	NA	p.Val18Ter	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V18Y	18	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val18Tyr	0	36.7	1.8	3.1	0.869	360	25.2	-54.4	-49.1	47.2727272727273	-0.7	0	0	29.08	0	0	0	0	4	21.7933697008369	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.877	-3.417	1.54	0.002327618	NA	NA	NA	NA	NA	NA	NA
Q19A	19	Q	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Ala	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-1.444	-3.258	1.814	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19C	19	Q	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Cys	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-1.444	-5.194	3.75	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19D	19	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Asp	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-1.444	-3.51	2.066	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19E	19	Q	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Glu	1	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-1.444	-2.434	0.99	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19F	19	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Phe	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-1.444	-4.374	2.93	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19G	19	Q	G	missense	possibly_low	0.393380059688125	0.703654645378146	5	0.314683923949809	-0.223389097767241	1.01014921714349	1.11820721320045	1.19972652417952	-0.204377230999635	NA	NA	NA	0.00414323899659032	-0.1507994469363	0.486584004087203	0.711457174739848	0.716722608902997	0.357368480655834	NA	NA	NA	0.486584004087203	0.437743336889632	NA	NA	p.Gln19Gly	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-1.444	-2.853	1.409	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19H	19	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19His	1	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-1.444	-4.59	3.146	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19I	19	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Ile	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-1.444	-2.722	1.278	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19K	19	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Lys	1	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-1.444	-2.848	1.404	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19L	19	Q	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Leu	1	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-1.444	-3.438	1.994	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19M	19	Q	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Met	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-1.444	-3.399	1.955	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19N	19	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Asn	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-1.444	-2.776	1.332	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19P	19	Q	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Pro	1	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-1.444	-3.071	1.627	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19R	19	Q	R	missense	low	0.355782631308734	0.183327307940164	6	0.0748430600619142	0.209092929094614	0.502472333522854	0.602124504961786	0.543633221554094	0.380523555976775	0.193301487278795	NA	NA	0.23120121297641	0.183911805104543	0.532835276438922	0.601532192741631	0.574867514948048	0.532379571355963	0.457154562244154	NA	NA	0.533290981521881	0.513020391943321	NA	NA	p.Gln19Arg	1	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-1.444	-3.693	2.249	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19S	19	Q	S	missense	possibly_wt-like	0.73744767488395	0.273135854411162	6	0.111507245627743	0.518897489438311	0.955997860329588	1.04792643472375	1.01112424903337	0.591920787049107	0.33807653103492	NA	NA	0.818501926352382	0.61713612111016	0.632277449544393	0.696487455379867	0.675944577251228	0.595632794474721	0.505104617380838	NA	NA	0.654101718472522	0.610453180616264	NA	NA	p.Gln19Ser	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-1.444	-2.662	1.218	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19T	19	Q	T	missense	wt-like	0.939424388453908	0.160589681062617	6	0.0655604627599502	0.810928242634626	1.06792053427319	0.727299627394017	0.960724182605508	0.823581961454235	1.15965815494234	NA	NA	1.07707866047351	0.88820374385384	0.668232089561612	0.628194339836131	0.665047489703083	0.664949293457564	0.777215632812535	NA	NA	0.707292264807623	0.671416689420142	NA	NA	p.Gln19Thr	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-1.444	-2.936	1.492	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19V	19	Q	V	missense	possibly_low	0.695778082868088	0.374284178303337	6	0.152800875940009	0.396293869219497	0.995262296516678	0.683609323922694	1.25168805594425	0.900785816723365	0.614687038723359	NA	NA	0.606665075584628	0.117233186310226	0.614707081131529	0.618888358942153	0.727957303634728	0.688049845239605	0.596719088707743	NA	NA	0.610525803320905	0.498024272072002	NA	NA	p.Gln19Val	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-1.444	-3.536	2.092	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19W	19	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Trp	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-1.444	-5.425	3.981	0.002773475	NA	NA	NA	NA	NA	NA	NA
Q19X	19	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Ter	1	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q19Y	19	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln19Tyr	0	33.2	2.8	4.2	0.31	89.3	115.5	-98.5	9.7	4.20560747663551	-2.8	0	0	23.25	2	179	0	0	7	18.1929386703416	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-1.444	-4.275	2.831	0.002773475	NA	NA	NA	NA	NA	NA	NA
K20A	20	K	A	missense	wt-like	0.892104249886418	0.207825495802267	6	0.0848444033760804	0.725812274979512	1.05839622479332	0.992032207253954	0.837045151922119	0.971206802480894	1.11690423267624	NA	NA	0.924270112151139	0.511166992834157	0.680220412345051	0.68458205368681	0.638306627621969	0.709120860700729	0.763055368192465	NA	NA	0.675858771003292	0.586620567118554	NA	NA	p.Lys20Ala	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.806	-2.159	0.353	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20C	20	K	C	missense	wt-like	1.0531699843769	0.12973681005084	6	0.0529648309134905	0.949360823339209	1.1569791454146	0.894236774438591	1.04012521778022	0.912238905479306	1.18233565585215	NA	NA	1.09355326507188	1.19653008763928	0.701078977899013	0.663751746799711	0.682214928022842	0.691476781225491	0.784726508933002	NA	NA	0.710681174572535	0.740759739628706	NA	NA	p.Lys20Cys	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.806	-5.2	3.394	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20D	20	K	D	missense	possibly_low	0.713415788028179	0.265540813855022	6	0.108406583304696	0.500942789063934	0.925888786992423	0.54697201605724	0.950518756216254	0.793295755313868	0.950048840766137	NA	NA	0.263596291152164	0.776063068663409	0.651041646051045	0.589784780450527	0.662840956404382	0.655887206197954	0.707792216240531	NA	NA	0.539954813488795	0.646196085904136	NA	NA	p.Lys20Asp	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.806	-3.714	1.908	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20E	20	K	E	missense	wt-like	0.861522900313363	0.102265201339555	6	0.041749593620816	0.77969520044738	0.943350600179345	0.824320380299845	0.87545097072753	0.874241773767093	0.969681332229596	NA	NA	0.682165615568856	0.943277329287257	0.664483555101815	0.648859640855468	0.646610417667161	0.680107469348161	0.714294573440499	NA	NA	0.626056647516946	0.683802820144452	NA	NA	p.Lys20Glu	1	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.806	-2.49	0.684	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20F	20	K	F	missense	wt-like	1.0415868594169	0.239829445557349	6	0.0979099611516837	0.849686861831889	1.23348685700192	0.579889907433203	1.01728329660811	1.24128100798513	1.11177795353058	NA	NA	1.20292970946495	1.09635928147946	0.725705820773384	0.596796250819824	0.677276235826146	0.789931114897178	0.761357524687788	NA	NA	0.733180464205968	0.718231177340799	NA	NA	p.Lys20Phe	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.806	-4.43	2.624	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20G	20	K	G	missense	wt-like	0.971569563661269	0.111069453931092	6	0.045343914690123	0.882697123950571	1.06044200337197	0.811445415265058	0.872132606054608	1.08722485077313	1.06268739375881	NA	NA	1.03722407426724	0.958703041848762	0.693183029937074	0.646117289141134	0.645892948169194	0.743835201362651	0.745098541187068	NA	NA	0.699093974186172	0.687272085687975	NA	NA	p.Lys20Gly	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.806	-2.951	1.145	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20H	20	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys20His	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.806	-3.516	1.71	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20I	20	K	I	missense	possibly_low	0.671498567418948	0.225282207665894	6	0.0919710761515264	0.491238570542565	0.85175856429533	0.831768752738063	1.02626345362103	0.540453242281547	0.397472803205686	NA	NA	0.572320008087561	0.660713144579802	0.61185728311328	0.65044613502223	0.679217851464805	0.580232932915308	0.524776892737213	NA	NA	0.603460848655536	0.620253717571024	NA	NA	p.Lys20Ile	1	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.806	-4.151	2.345	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20K	20	K	K	synonymous	wt-like	1.10779169006795	0.299794764225713	6	0.122390699985164	0.867910326054382	1.34767305408152	0.508617263661028	1.25056122190903	1.2343427115467	1.19032359660674	NA	NA	1.32250380348518	1.14040154319902	0.742956904590053	0.581615265372044	0.727713668853976	0.787855072507893	0.787372145844406	NA	NA	0.757777462114844	0.728136347065262	NA	NA	p.Lys20=	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20L	20	K	L	missense	wt-like	1.05203241214942	0.182226137457166	6	0.0743935090947211	0.906223813640214	1.19784101065863	1.31957249465268	1.16118093122753	1.06973928863585	1.05904451487093	NA	NA	0.822920833360103	0.879736410149432	0.723495928439205	0.754347731980657	0.708388598042234	0.738603258836175	0.743892005592271	NA	NA	0.65501071006739	0.669512373561209	NA	NA	p.Lys20Leu	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.806	-3.599	1.793	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20M	20	K	M	missense	possibly_wt-like	1.17496918140858	0.571631846527432	6	0.233367724119526	0.717576846980234	1.63236151583693	0.806311944949781	0.188233389397979	1.46781942303255	1.353272646741	NA	NA	1.5283020752178	1.70587560911239	0.820726356594721	0.645023866278893	0.498025888337416	0.857714807423698	0.841341502272782	NA	NA	0.800111210916659	0.855312299865319	NA	NA	p.Lys20Met	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.806	-3.586	1.78	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20N	20	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys20Asn	1	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.806	-3.143	1.337	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20P	20	K	P	missense	wt-like	0.897144165379222	0.11243048900962	6	0.0458995549341935	0.807182690801785	0.987105639956659	0.944222233134988	1.06066819487025	0.780419853360255	0.771036444160583	NA	NA	0.959082243569522	0.867436023179732	0.670572293186505	0.674398588012676	0.686656561451441	0.652034543156931	0.648502617255186	NA	NA	0.683019803087354	0.666745998360333	NA	NA	p.Lys20Pro	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.806	-4.033	2.227	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20Q	20	K	Q	missense	wt-like	1.23520676229537	0.220828449541048	6	0.0901528370109182	1.05851044864986	1.41190307594087	1.29458551207158	0.900178282708406	1.44128546500636	1.46047662706798	NA	NA	1.05077382019637	1.26394086672149	0.752473029429445	0.749025535428497	0.651956753546927	0.849775449094636	0.876847875706935	NA	NA	0.701881225680867	0.755920523430394	NA	NA	p.Lys20Gln	1	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.806	-2.651	0.845	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20R	20	K	R	missense	possibly_wt-like	0.786458819387666	0.110403751473439	4	0.0552018757367194	0.678265131064641	0.894652507710692	0.884367132065051	0.855660477721729	NA	NA	NA	NA	0.767048929582964	0.638758738180922	0.642924528048513	0.661649525115239	0.642331480153977	NA	NA	NA	NA	0.643517575943049	0.615316139138621	NA	NA	p.Lys20Arg	1	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.806	-2.208	0.402	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20S	20	K	S	missense	wt-like	1.22573661739577	0.210484552924539	6	0.0859299589004935	1.05731699275779	1.39415624203374	1.00290944950387	1.05490648092615	1.32340541029007	1.39140993245783	NA	NA	1.51135508195122	1.07043334924547	0.754512762643267	0.686898892905457	0.685410811083906	0.814503968175053	0.853972718989704	NA	NA	0.796625128405599	0.712400396880934	NA	NA	p.Lys20Ser	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.806	-2.963	1.157	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20T	20	K	T	missense	wt-like	1.18280111106741	0.143674618649315	6	0.0586549174466302	1.06783958535585	1.29776263677898	0.931297847986922	1.31622238710842	1.16457741697513	1.14478624082183	NA	NA	1.32088187024346	1.21904090326871	0.751633138767849	0.671645709875007	0.741910385572891	0.766980249686908	0.772289997263997	NA	NA	0.757443822216655	0.745822455319043	NA	NA	p.Lys20Thr	1	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.806	-2.863	1.057	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20V	20	K	V	missense	wt-like	0.991251725616887	0.115690510380985	6	0.0472304530859291	0.898681738594957	1.08382171263882	0.930769407252138	1.05437789749725	1.14814759394807	1.05992373177918	NA	NA	0.832953146037147	0.921338577187529	0.682082643756221	0.671533152648557	0.685296525125387	0.762064200141413	0.74418320563707	NA	NA	0.657074407693204	0.678868762387054	NA	NA	p.Lys20Val	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.806	-3.742	1.936	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20W	20	K	W	missense	wt-like	0.963434387222686	0.184834267724102	6	0.0754582738175045	0.815538888204815	1.11132988624056	0.871368545647971	0.638347061867719	0.982260276541628	1.09307411368594	NA	NA	1.139029050528	1.05652727506485	0.710850563114325	0.658880842198549	0.595345761963768	0.71242822597441	0.755162740500198	NA	NA	0.720035774403996	0.709272900254239	NA	NA	p.Lys20Trp	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.806	-3.67	1.864	0.002604079	NA	NA	NA	NA	NA	NA	NA
K20X	20	K	X	nonsense	possibly_wt-like	0.786835721443096	0.265676119548605	4	0.132838059774303	0.526477908509284	1.04719353437691	NA	NA	0.92132674828268	1.08281197236601	NA	NA	0.653487934429962	0.489716230693728	0.657176751560422	NA	NA	0.694196000136705	0.751763879554662	NA	NA	0.620157502984139	0.581796259023911	NA	NA	p.Lys20Ter	1	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K20Y	20	K	Y	missense	wt-like	1.14689895351635	0.164457631285974	6	0.0671395468262353	1.01530785979859	1.27849004723411	1.01085565627557	0.960536204008079	1.06165143693806	1.18542879402293	NA	NA	1.28088977456874	1.38203185528474	0.742700248733165	0.688591425172841	0.665006846517894	0.736183252266569	0.785750968273411	NA	NA	0.749217245199761	0.782479361214357	NA	NA	p.Lys20Tyr	0	32.6	5.1	1.3	0.718	73.7	47.5	-60.3	-28.8	42.6086956521739	-2	0	0	24.38	1	3	1	3	7	18.7031416711712	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.806	-4.333	2.527	0.002604079	NA	NA	NA	NA	NA	NA	NA
N21A	21	N	A	missense	wt-like	1.12957454238859	0.224280047154316	6	0.0915619458359039	0.950116426195808	1.30903265858137	0.929937400975457	0.895762552896134	1.28785378320032	1.27456023945643	NA	NA	1.42098227094297	0.968351006860204	0.733738454931905	0.671355936335112	0.651002020790331	0.803866387970545	0.815271648164541	NA	NA	0.7780349825918	0.689441927272009	NA	NA	p.Asn21Ala	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.918	-3.407	1.489	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21C	21	N	C	missense	wt-like	1.07796048067102	0.274993581470225	6	0.112265659523754	0.857923831303821	1.29799713003821	0.612080284444143	0.950595126783086	1.12425468261314	1.35791842225058	NA	NA	1.09171012372663	1.33120424420852	0.732608556825407	0.603652761524319	0.662857468619778	0.754915082605865	0.842880201112426	NA	NA	0.710302031044949	0.771048156395568	NA	NA	p.Asn21Cys	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.918	-3.718	1.8	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21D	21	N	D	missense	wt-like	1.07548650215943	0.360902268711985	6	0.147337734226198	0.786709849512347	1.36426315480651	0.614455024144262	0.721644820720537	1.35172795635955	1.37561227160511	NA	NA	1.43832818013762	0.951150759989494	0.733588345237177	0.60415857815917	0.613355717805444	0.822978498880759	0.848740472538482	NA	NA	0.781603124133531	0.685573566340822	NA	NA	p.Asn21Asp	1	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.918	-1.945	0.027	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21E	21	N	E	missense	wt-like	1.0235292505496	0.137944879583405	6	0.0563157612681685	0.913152386702038	1.13390611439717	1.21168506744386	1.07993407677057	0.874034498017638	0.847656736374245	NA	NA	1.06668534994228	1.06117977474903	0.697988189980265	0.731367842702369	0.690822071869179	0.680045449334177	0.673879554750179	NA	NA	0.70515430809135	0.71031925430636	NA	NA	p.Asn21Glu	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.918	-2.56	0.642	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21F	21	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn21Phe	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.918	-4.399	2.481	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21G	21	N	G	missense	wt-like	0.899030312245785	0.139779239204664	6	0.0570646354476436	0.787185681977496	1.01087494251407	0.900148308625472	1.08060193821803	0.979215745089134	0.964250856012959	NA	NA	0.745348063648028	0.724616961881087	0.677988683842013	0.665010896309472	0.690966471374554	0.711517256486874	0.712495978687906	NA	NA	0.639053597700972	0.63462578048734	NA	NA	p.Asn21Gly	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.918	-2.345	0.427	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21H	21	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn21His	1	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.918	-3.564	1.646	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21I	21	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn21Ile	1	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.918	-3.115	1.197	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21K	21	N	K	missense	wt-like	1.05718145742411	0.00668740906082932	2	0.00472871229548077	1.04791335163172	1.06644956321651	NA	NA	1.06191016971959	1.05245274512863	NA	NA	NA	NA	0.7389847274617	NA	NA	0.736260668996558	0.741708785926842	NA	NA	NA	NA	NA	NA	p.Asn21Lys	1	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.918	-3.707	1.789	0.00216686	NA	NA	NA	NA	4.06e-06	NA	NA
N21L	21	N	L	missense	wt-like	1.07640406891785	0.17631335988833	6	0.0719796277603507	0.935326590886958	1.21748154694873	0.820338654112425	1.07897168198307	0.911632892704091	1.1810886936783	NA	NA	1.19728015842786	1.26911233260132	0.711656888000313	0.648011538075649	0.690613990789162	0.691295453111168	0.784313510232135	NA	NA	0.732018322889457	0.757083593746586	NA	NA	p.Asn21Leu	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.918	-3.134	1.216	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21M	21	N	M	missense	wt-like	1.10841510571189	0.250435684926282	6	0.102239940242301	0.908028505055454	1.30880170636833	0.976035718331946	1.11104513519937	1.1847100795202	1.39038338345232	NA	NA	0.690330403661332	1.29798591410618	0.730562976873445	0.681174821224425	0.697548648864853	0.773004244369705	0.853632721983745	NA	NA	0.627736185859114	0.763577304882038	NA	NA	p.Asn21Met	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.918	-4.897	2.979	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21N	21	N	N	synonymous	wt-like	1.21870229535051	0.173711101490738	6	0.0709172602181882	1.07970701944061	1.35769757126042	1.51036167312302	1.13061436686887	1.13957754718698	1.10961046519334	NA	NA	1.35204510470381	1.07000461502705	0.760069778865682	0.794985592296466	0.701779747072981	0.759499913574518	0.760639644156847	NA	NA	0.76385425768042	0.712303973921843	NA	NA	p.Asn21=	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	0	-3.5	-3.5	0	187	187	0	11.6	11.6	0	132	132	0	5.47	5.47	0	NA	NA	NA	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21P	21	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn21Pro	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.918	-3.307	1.389	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21Q	21	N	Q	missense	wt-like	1.31031153524265	0.0680194946287879	6	0.0277688424004186	1.25588560424546	1.36473746623984	1.25300533278678	1.3834861257561	1.35464228908878	1.25835073674952	NA	NA	1.37617686626251	1.23620786081224	0.762635940510296	0.740169008390489	0.756453597532906	0.82385051095693	0.809902998096344	NA	NA	0.768818283487686	0.749683329431369	NA	NA	p.Asn21Gln	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.918	-3.107	1.189	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21R	21	N	R	missense	wt-like	0.85417472008769	0.0754106382957738	6	0.0307862641670384	0.793834751101758	0.914514689073621	0.834346163305362	0.793719340265423	0.828231547872041	0.774351097459062	NA	NA	0.943107349755572	0.951292821868679	0.658667819886878	0.650995120302475	0.628939077216194	0.66634051947128	0.649600443263713	NA	NA	0.679733686366538	0.685605516267319	NA	NA	p.Asn21Arg	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.918	-4.042	2.124	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21S	21	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn21Ser	1	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.918	-2.692	0.774	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21T	21	N	T	missense	wt-like	0.986740093606786	0.115211201963143	8	0.0407333110883956	0.906904270902464	1.06657591631111	0.909988301354413	0.941616606423108	1.09404520633909	1.01234841680277	0.797395606094625	1.17737921764761	0.997119811465438	0.964027582727226	0.689656953309777	0.667106802656117	0.660916206844747	0.745875954073433	0.728426077080393	0.622577332074989	0.706224395761371	0.690844323822056	0.688469582797498	NA	NA	p.Asn21Thr	1	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.918	-3.108	1.19	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21V	21	N	V	missense	wt-like	1.06623733104493	0.210064228684203	6	0.0857583622479357	0.898154029665837	1.23432063242402	0.715189606456623	0.910322780931747	1.1706048571611	1.14733420615223	NA	NA	1.2713784067423	1.18259412882559	0.742443115238545	0.625614920273549	0.65415011345906	0.768783750219929	0.773133893248476	NA	NA	0.747260708573209	0.737625521903882	NA	NA	p.Asn21Val	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.918	-3.174	1.256	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21W	21	N	W	missense	wt-like	0.975043070505464	0.301998875280803	6	0.123290524555397	0.733398082741835	1.21668805826909	1.29172949818668	1.1233725188434	0.709634812358122	0.694593775874032	NA	NA	0.714329681397023	1.31659813637354	0.66644346668412	0.748417207984324	0.700213974296532	0.630854596904719	0.623184509492706	NA	NA	0.632672959071709	0.767763221165844	NA	NA	p.Asn21Trp	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.918	-5.594	3.676	0.00216686	NA	NA	NA	NA	NA	NA	NA
N21X	21	N	X	nonsense	possibly_low	0.674517727081026	0.339121305159698	4	0.169560652579849	0.342184954829413	1.00685049933264	NA	NA	1.11346448332265	0.764743597015917	NA	NA	0.455664237390293	0.364198590595239	0.612941283287333	NA	NA	0.751686493093341	0.646418401911679	NA	NA	0.579464164662987	0.553567156338262	NA	NA	p.Asn21Ter	0	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N21Y	21	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn21Tyr	1	29.8	3.2	-0.4	0.322	77.1	125.2	-98.7	8.7	66.3101604278075	-1.2	0	0	22.34	0	0	0	0	4	18.9159576502604	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.918	-3.466	1.548	0.00216686	NA	NA	NA	NA	NA	NA	NA
Q22A	22	Q	A	missense	possibly_low	0.620905651452414	0.383553024792404	6	0.156584866673743	0.314004952247872	0.927806350656956	1.0687322124387	1.14801424864199	0.486946084101778	0.294234923594967	NA	NA	0.35237701626934	0.37512942366771	0.561220123789319	0.700919060439024	0.705541806301224	0.564222788422746	0.490584107219102	NA	NA	0.558217459155892	0.556025516844406	NA	NA	p.Gln22Ala	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.122	-2.711	0.589	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22C	22	Q	C	missense	wt-like	1.11352097957532	0.311030735454665	6	0.126977766031085	0.864649131317043	1.3623928278336	0.536420457247447	0.978075408503504	1.23064928269441	1.32458357194298	NA	NA	1.29623390676237	1.31516325030123	0.759907062111475	0.587537311403989	0.668799028958467	0.786749943182961	0.83183956960058	NA	NA	0.752373611054528	0.767440513168423	NA	NA	p.Gln22Cys	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.122	-5.237	3.115	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22D	22	Q	D	missense	wt-like	1.25377424462719	0.0944069636308012	2	0.0667558041745713	1.12293527268602	1.38461321656836	1.18701844045262	1.32053004880176	NA	NA	NA	NA	NA	NA	0.734477817113512	0.726113881496765	0.74284175273026	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln22Asp	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.122	-2.898	0.776	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22E	22	Q	E	missense	wt-like	1.00840319176303	0.154617485194739	6	0.0631223240065739	0.88468571008968	1.13212067343639	0.834978463342676	1.09765161558855	0.800849522042549	1.0240502438222	NA	NA	1.14109815761933	1.15179114816289	0.7075571062607	0.651129799432603	0.694652812289205	0.658147406531954	0.732301767504819	NA	NA	0.720461400232195	0.730697886047527	NA	NA	p.Gln22Glu	1	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.122	-3.482	1.36	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22F	22	Q	F	missense	possibly_wt-like	0.93486009033122	0.442675040749307	6	0.180721328616925	0.580652795003818	1.28906738565862	1.55181927622732	1.27704512983768	0.711395499824465	1.07277849462699	NA	NA	0.372498250412569	0.623623891058297	0.682410611231079	0.803816010758814	0.733439801452005	0.631381421010153	0.748440752872626	NA	NA	0.562356499122703	0.611912289661998	NA	NA	p.Gln22Phe	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.122	-4.392	2.27	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22G	22	Q	G	missense	wt-like	0.952453294571264	0.141738803687264	6	0.0578646242977185	0.839040714968795	1.06586587417373	0.777319979060429	0.83544865615516	1.06365609230186	1.12018962773662	NA	NA	1.04708404876995	0.871021363403569	0.684337283824158	0.638848613208786	0.637961446447105	0.736783075227159	0.764143503759228	NA	NA	0.701122220975011	0.667552346673305	NA	NA	p.Gln22Gly	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.122	-2.604	0.482	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22H	22	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln22His	1	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.122	-2.789	0.667	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22I	22	Q	I	missense	wt-like	1.06302394493375	0.148461274701226	2	0.104977974084836	0.857270896557494	1.26877699331001	0.958045970848915	1.16800191901859	NA	NA	NA	NA	NA	NA	0.693603201511602	0.677343027140539	0.709863375882664	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln22Ile	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.122	-3.024	0.902	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22K	22	Q	K	missense	wt-like	0.975737111279629	0.0675654859499599	6	0.0275834941334313	0.921674456210332	1.02979976634893	0.988002321830419	0.997132937636564	1.00869004328485	0.918164736262788	NA	NA	0.876940367293089	1.06549226137007	0.690477885203021	0.683723693048941	0.672919491055704	0.720336408708429	0.6972320773571	NA	NA	0.666122802315091	0.711289138918277	NA	NA	p.Gln22Lys	1	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.122	-2.959	0.837	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22L	22	Q	L	missense	possibly_low	0.55149447358055	0.282022200442406	6	0.115135081203469	0.325833861064656	0.777155086096444	1.00781341183274	0.743958542497961	0.343505515525127	0.438638144028628	NA	NA	0.24150218292055	0.533549044678293	0.565032668337424	0.68794343084892	0.618180207076337	0.52130321827305	0.538411013031492	NA	NA	0.535409943310816	0.591654323643357	NA	NA	p.Gln22Leu	1	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.122	-2.65	0.528	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22M	22	Q	M	missense	wt-like	1.24986351879856	0.270406402594521	6	0.110392951589696	1.03349730953568	1.46622972806144	1.06523575947808	1.17955027703596	0.999128498101306	1.13189804917163	NA	NA	1.72799495840219	1.39537357060218	0.742748414608885	0.700174320259558	0.712360266805075	0.717475450938137	0.768021378279632	NA	NA	0.841189050312812	0.785479932698997	NA	NA	p.Gln22Met	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.122	-4.682	2.56	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22N	22	Q	N	missense	wt-like	1.37096940566564	0.122355317232993	6	0.0499513490895329	1.27306656047097	1.46887225086032	1.15513866471269	1.39048581473926	1.40489828350825	1.3248819360283	NA	NA	1.43722813882745	1.51318359617792	0.796676210772981	0.719323528480909	0.757967012674302	0.838887858475366	0.831938388941063	NA	NA	0.78137684005396	0.811975581492002	NA	NA	p.Gln22Asn	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.122	-3.14	1.018	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22P	22	Q	P	missense	possibly_low	0.694852383676704	0.0926151291061001	6	0.0378099681286553	0.620746207887933	0.768958559465476	0.564996642006788	0.760412189547039	0.606613424827163	0.803551711734574	NA	NA	0.692637485003407	0.740902848941255	0.624974221709377	0.593624003604875	0.62173767922048	0.600029052130813	0.659271799791807	NA	NA	0.628210764198274	0.63828850054635	NA	NA	p.Gln22Pro	1	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.122	-3.243	1.121	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22Q	22	Q	Q	synonymous	wt-like	1.09494134175139	0.44349358889642	6	0.181055499498647	0.740079083531137	1.44980359997165	0.810417748681199	0.386846633385418	1.60087277275741	1.41024312446011	NA	NA	1.05610924000746	1.30515853121677	0.734084592838245	0.645898397422951	0.540968409277339	0.89752636585402	0.860210345112824	NA	NA	0.702978748610156	0.765190437066333	NA	NA	p.Gln22=	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22R	22	Q	R	missense	wt-like	1.21269445429243	0.303942399204506	8	0.107459865783807	1.00207698757265	1.4233119210122	0.840232032368075	0.867719409804127	1.13272939970725	1.14449776856152	1.69692669724541	1.59123668542444	1.22140626756113	1.20680737366746	0.748586571841722	0.65224880317236	0.644938763198477	0.757450845106173	0.772194454134266	0.754102027244343	0.785739544002663	0.736981185964128	0.743071116439101	NA	NA	p.Gln22Arg	1	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.122	-1.875	-0.247	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22S	22	Q	S	missense	wt-like	1.22078140708089	0.242972008741204	6	0.0991929071991674	1.0263668814487	1.41519593271308	0.896964312816694	0.968147433276136	1.40885769151737	1.31254131735609	NA	NA	1.50821610286261	1.22996158465645	0.772128978587438	0.664332709118979	0.666652483866442	0.840072572754494	0.827851128247497	NA	NA	0.79597942447858	0.748278532696295	NA	NA	p.Gln22Ser	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.122	-3.572	1.45	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22T	22	Q	T	missense	possibly_low	0.700119084077591	0.38925124935155	6	0.158911157108693	0.388658939402966	1.01157922875222	1.03428276934782	1.04132827701286	0.38172415787545	0.979684936637724	NA	NA	0.110399957460456	0.653294406131239	0.650530137961317	0.693581371438481	0.682475043588412	0.532738809456616	0.717607805959657	NA	NA	0.508441550266206	0.618585232334223	NA	NA	p.Gln22Thr	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.122	-3.713	1.591	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22V	22	Q	V	missense	wt-like	0.997308665673972	0.0288084110316859	6	0.011760984554666	0.974257559524094	1.02035977182385	0.983513380562557	0.986764786366083	0.979289661142558	1.02902020936145	NA	NA	1.03771158496383	0.967552371647346	0.694228285321553	0.682767554080936	0.670677774722482	0.711539373279017	0.733947839337723	NA	NA	0.699194257610295	0.689262313032812	NA	NA	p.Gln22Val	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.122	-3.083	0.961	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22W	22	Q	W	missense	possibly_low	0.508503935455263	0.322995371768782	6	0.131862308352345	0.250058560166351	0.766949310744174	0.617908000151254	0.9803672754465	0.533173162058808	0.634931308553945	NA	NA	0.108894242283977	0.175749624237093	0.59073934648101	0.604894057800998	0.669294557565801	0.578054623689991	0.603424069272029	NA	NA	0.508131817013776	0.511184705408223	NA	NA	p.Gln22Trp	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.122	-5.533	3.411	0.00184999	NA	NA	NA	NA	NA	NA	NA
Q22X	22	Q	X	nonsense	wt-like	0.858302526719454	0.16315284964411	6	0.0666068719515156	0.727755456571612	0.988849596867295	0.928988474558258	0.939956477620244	0.828592773925465	1.0948683246262	NA	NA	0.672643134783955	0.684765974802596	0.663502935592254	0.671153816175566	0.660557267458587	0.666448603725921	0.755756990111736	NA	NA	0.624097824898446	0.625663234621432	NA	NA	p.Gln22Ter	1	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q22Y	22	Q	Y	missense	possibly_wt-like	0.799455038467469	0.134654168651268	6	0.054972334155713	0.691711243376171	0.907198833558768	0.616898730575945	0.707522223429405	0.866983285083033	0.727060712000819	NA	NA	0.944592053203805	0.933673226511808	0.655936652551001	0.604679084623005	0.610302246054392	0.677935620635153	0.633937684466848	NA	NA	0.680039097399845	0.68164284324209	NA	NA	p.Gln22Tyr	0	27.7	2.6	2.8	0.544	35.4	-178.9	-70.4	124.4	32.7102803738318	-3.2	0	0	18.08	0	0	0	0	5	15.76908826583	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.122	-4.275	2.153	0.00184999	NA	NA	NA	NA	NA	NA	NA
V23A	23	V	A	missense	wt-like	1.0532015012552	0.164836317731515	6	0.067294144920249	0.921307400841096	1.18509560166931	1.0328854498921	0.829001862825992	1.11402220779107	1.09461339652322	NA	NA	1.31094488932481	0.937741201174027	0.722568558367561	0.69328374411332	0.636567573853439	0.751853372621803	0.755672556936812	NA	NA	0.755399734817295	0.682557736753252	NA	NA	p.Val23Ala	1	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.534	-2.274	0.74	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23C	23	V	C	missense	wt-like	1.03902391295749	0.0717667179315333	6	0.0292986399077507	0.981599633942291	1.09644819197269	0.961073935498582	0.951441817105881	1.04274610622044	1.08232324973115	NA	NA	1.13761380542935	1.05894456375953	0.714780601679199	0.677987979886082	0.663040533032737	0.730526493680139	0.751602012725407	NA	NA	0.719744651305659	0.709816552052739	NA	NA	p.Val23Cys	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.534	-5.006	3.472	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23D	23	V	D	missense	possibly_low	0.614738713722217	0.325290863076946	6	0.132799438754678	0.354456596595915	0.875020830848518	0.795077467119841	0.774951820902688	0.831212189222509	0.851005236369196	NA	NA	0.38171093805656	0.0544746306625058	0.63375612748287	0.642630936321154	0.624881318644587	0.667232372081751	0.674988590915649	NA	NA	0.564251595720098	0.483909780193471	NA	NA	p.Val23Asp	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.534	-3.187	1.653	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23E	23	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val23Glu	1	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.534	-2.734	1.2	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23F	23	V	F	missense	wt-like	0.970567835315521	0.248335941659111	6	0.101382723643066	0.771861348320535	1.16927432231051	0.652244695501787	0.649241637921658	1.14565999113687	1.10036481762926	NA	NA	1.12706588457023	1.14882998513332	0.723803403284011	0.612207731671544	0.59770129753096	0.761319872058923	0.757577449879644	NA	NA	0.71757489046038	0.730031916107643	NA	NA	p.Val23Phe	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.534	-4.1	2.566	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23G	23	V	G	missense	wt-like	0.989465309483952	0.0619713852124387	6	0.0252997120706556	0.939878785006234	1.03905183396167	1.05959123754814	1.02923533895883	1.02593600351193	0.933265531761487	NA	NA	0.898832982421197	0.989930762702125	0.696633645136371	0.698972044032062	0.679860408052611	0.725496658748638	0.702233519304444	NA	NA	0.670626224339219	0.69429524624068	NA	NA	p.Val23Gly	1	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.534	-3.705	2.171	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23H	23	V	H	missense	possibly_wt-like	0.925522814905916	0.406118718581711	6	0.165797272586358	0.600566131901685	1.25047949791015	1.21102597995301	1.26117526424353	0.590042779898963	1.39581148921035	NA	NA	0.621797594895432	0.473283781234222	0.671823594530565	0.731227457877591	0.730008549729267	0.595070866559752	0.855430531631266	NA	NA	0.613638639331863	0.578100576864773	NA	NA	p.Val23His	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.534	-4.861	3.327	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23I	23	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val23Ile	1	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.534	-2.375	0.841	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23K	23	V	K	missense	possibly_wt-like	0.787913495946306	0.374438026087533	6	0.152863684034899	0.488306180693794	1.08752081119882	0.909955408844826	1.08008691561359	1.02217686451473	0.79293191208725	NA	NA	0.0535340443794874	0.868795830237951	0.667075808784305	0.667099796592038	0.690855117425885	0.724371867962505	0.655754481023197	NA	NA	0.496743943384048	0.667051820976573	NA	NA	p.Val23Lys	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.534	-3.766	2.232	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23L	23	V	L	missense	wt-like	1.093993357974	0.18501868351168	6	0.075533561247518	0.945950298304812	1.24203641764318	1.20196126973117	1.17094245267935	1.13805199052196	1.26151237044425	NA	NA	1.04570193596766	0.745790128499601	0.719897919810074	0.729296685751249	0.710499153868898	0.759043444132494	0.810950143419537	NA	NA	0.70083791335816	0.639387656939011	NA	NA	p.Val23Leu	1	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.534	-2.784	1.25	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23M	23	V	M	missense	wt-like	1.02984099025269	0.172489610179654	6	0.0704185884786221	0.891823092992443	1.16785888751294	1.12067841078779	0.992131305421362	0.96754498645699	1.23736144084663	NA	NA	0.740306622133018	1.12102317587035	0.710004363597178	0.711983536786019	0.671838079303784	0.708025190408337	0.802951262011781	NA	NA	0.638016547598954	0.723778123625338	NA	NA	p.Val23Met	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.534	-3.504	1.97	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23N	23	V	N	missense	wt-like	1.25724819156198	0.149472755794777	6	0.0610219970241403	1.13764727512996	1.37684910799401	1.17414168492923	0.989351788399189	1.35211211760806	1.35313801723477	NA	NA	1.30573869176446	1.36900684943619	0.766939405858929	0.723371148410562	0.671237115009907	0.823093445689865	0.841296912458963	NA	NA	0.75432879356071	0.779550018157148	NA	NA	p.Val23Asn	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.534	-4.1	2.566	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23P	23	V	P	missense	wt-like	1.09724419990487	0.118580028478976	6	0.0484100939096982	1.00236215935366	1.19212624045608	1.01585460184215	0.988823845127207	1.07174291906619	1.01500697031628	NA	NA	1.25711019686615	1.23492666621124	0.734254687710337	0.689656194429095	0.671122967460846	0.739202775121299	0.729306600299375	NA	NA	0.744325665398826	0.749395186872893	NA	NA	p.Val23Pro	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.534	-4.13	2.596	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23Q	23	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val23Gln	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.534	-3.096	1.562	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23R	23	V	R	missense	wt-like	1.0406862494145	0.319269085289417	6	0.130341058267366	0.785222469503624	1.29615002932537	0.929337377891515	0.736811549986065	1.47986498207794	1.2847020556754	NA	NA	0.665247408443349	1.14815412241273	0.700554022869838	0.671228132156348	0.616634943178331	0.861319019408987	0.818630656970677	NA	NA	0.622576486461177	0.729879913583329	NA	NA	p.Val23Arg	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.534	-3.323	1.789	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23S	23	V	S	missense	wt-like	1.00160487502135	0.196715397768211	6	0.0803087248467909	0.844202666677299	1.15900708336539	0.848640564093052	0.742447893811313	1.18757802112273	1.22679813868175	NA	NA	0.908205150991401	1.09595948142784	0.695347694345486	0.654039810086066	0.617853587050618	0.773862375524765	0.799452655428142	NA	NA	0.672554126972409	0.718141261718564	NA	NA	p.Val23Ser	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.534	-3.074	1.54	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23T	23	V	T	missense	wt-like	0.909258286849752	0.169685997120845	6	0.0692740182402409	0.773483706034509	1.045032867665	1.17568386842805	1.03542563346102	0.766280404024431	0.76921662100376	NA	NA	0.780281327093288	0.928661867087957	0.664207832941357	0.723699631598701	0.681198822581008	0.647803807782212	0.64789988477834	NA	NA	0.646239547257636	0.680515781104373	NA	NA	p.Val23Thr	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.534	-2.836	1.302	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23V	23	V	V	synonymous	wt-like	0.989082386699704	0.151485527124492	6	0.061843707478591	0.867870947371235	1.11029382602817	0.822739128757091	0.893703554894191	1.18566596586368	0.851893646173846	NA	NA	1.08588073869384	1.09461128581558	0.692192866323152	0.64852283622203	0.650556841188818	0.77329025990479	0.675282835683336	NA	NA	0.709102896962968	0.717838050533675	NA	NA	p.Val23=	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23W	23	V	W	missense	wt-like	0.932314804290513	0.146739735199307	6	0.0599062460382372	0.814900719606573	1.04972888897445	0.910967451032127	1.05298875843227	0.811949763516144	1.16687842120703	NA	NA	0.838600255841423	0.812504175714088	0.664392062825093	0.667315360332974	0.684996176909986	0.661468765317212	0.779607012960046	NA	NA	0.658236046835739	0.654391744714365	NA	NA	p.Val23Trp	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.534	-5.434	3.9	0.001566786	NA	NA	NA	NA	NA	NA	NA
V23X	23	V	X	nonsense	wt-like	0.997009984308049	0.103897628008835	6	0.0424160290178571	0.913876095065844	1.08014387355025	1.11779724012888	0.954433718256444	0.833975114366838	1.00103217012087	NA	NA	0.975321048799293	1.09950061417598	0.698865029352765	0.711369850979929	0.663687417274838	0.66805908073696	0.724678092356922	NA	NA	0.6863602077256	0.718937667704943	NA	NA	p.Val23Ter	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V23Y	23	V	Y	missense	wt-like	1.10286657819961	0.233500862559384	6	0.095326327961706	0.916030408616215	1.28970274778301	0.873557317763787	0.788148099695022	1.29610014135471	1.38545518546044	NA	NA	1.10993904823958	1.16399967668413	0.723747707733042	0.65934704796671	0.627734509433841	0.806333822050031	0.852000483724273	NA	NA	0.714051813318442	0.733443602147642	NA	NA	p.Val23Tyr	0	24.2	3.9	2.2	0.892	3.6	-172.7	-131.7	99	65.4545454545455	-0.7	0	0	15.06	0	0	0	0	4	14.1998296791671	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.534	-2.888	1.354	0.001566786	NA	NA	NA	NA	NA	NA	NA
L24A	24	L	A	missense	wt-like	0.967997888268763	0.110542014157285	6	0.0451285883041437	0.879547480519506	1.05644829601802	0.835019242364114	1.03950623405487	1.03615115438438	1.06041389298254	NA	NA	0.817937129718265	1.01895967610841	0.691452494103246	0.651138485314005	0.682081096456258	0.728553185147064	0.744345548925783	NA	NA	0.65398553693887	0.700823891750233	NA	NA	p.Leu24Ala	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.877	-2.708	0.831	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24C	24	L	C	missense	wt-like	1.12022238200548	0.240781696227377	6	0.0982987158598157	0.927560439193709	1.31288432481726	1.02967136726665	1.19558076002353	1.14692827372132	1.00806565470926	NA	NA	0.8116263947191	1.52946184159305	0.721416927794296	0.692599148467885	0.715826245898666	0.76169936123617	0.727007609689926	NA	NA	0.652687386726235	0.815636582933755	NA	NA	p.Leu24Cys	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.877	-4.974	3.097	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24D	24	L	D	missense	possibly_low	0.621792300055836	0.145599552389369	6	0.0594407683552634	0.505290534866131	0.73829406524554	0.452029059528925	0.512638012764479	0.576113114675268	0.783362558487463	NA	NA	0.594260621212776	0.812350433666102	0.599438522924997	0.569562047503609	0.568165986007865	0.590902901738763	0.652585074053408	NA	NA	0.607974144111231	0.654357167900649	NA	NA	p.Leu24Asp	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.877	-3.276	1.399	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24E	24	L	E	missense	wt-like	0.805016155052817	0.0862350631941525	6	0.035205317127056	0.736015001419476	0.874017308686157	0.65153846628236	0.870038634009652	0.812881013774474	0.885048809887276	NA	NA	0.767007475542903	0.843582530820233	0.653410759728907	0.61205730571657	0.645440206767952	0.661747409366005	0.686263954299351	NA	NA	0.643509048636653	0.661381312689863	NA	NA	p.Leu24Glu	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.877	-3.893	2.016	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24F	24	L	F	missense	possibly_wt-like	0.794807777216433	0.489424895049536	3	0.282569594904954	0.240981548076651	1.34863400635622	0.824233656984681	1.26885583832783	NA	NA	NA	NA	0.291333836336784	NA	0.648841168896021	0.648841168896021	0.731669180243247	NA	NA	NA	NA	0.545660567285165	NA	NA	NA	p.Leu24Phe	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.877	-4.047	2.17	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24G	24	L	G	missense	possibly_low	0.697556790004451	0.152789987952769	6	0.0623762513817122	0.575301583805679	0.819811996203224	0.838645697628797	0.880535485882491	0.745504681469477	0.645591747798784	NA	NA	0.477861189779855	0.597201937467304	0.624271123964687	0.651910915824316	0.647709749686153	0.64158739989666	0.606954848032714	NA	NA	0.58403019040613	0.605969953266171	NA	NA	p.Leu24Gly	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.877	-3.802	1.925	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24H	24	L	H	missense	possibly_wt-like	0.809859891737166	0.424734946807546	6	0.17339731593444	0.47000739748975	1.14971238598458	0.967612957243569	1.46025025922092	0.468553238517067	0.33274047772834	NA	NA	1.04943582913036	0.580566588582741	0.640804711100206	0.679380783473819	0.773050906667822	0.558719373076872	0.503337295861711	NA	NA	0.701605994129063	0.602228638726593	NA	NA	p.Leu24His	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.877	-4.988	3.111	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24I	24	L	I	missense	wt-like	1.58545415390098	0.276487344327766	6	0.112875485656704	1.36422226727637	1.80668604052559	1.33353000821847	1.29748734021667	1.66632969340922	1.41471885448154	NA	NA	1.8699056961302	1.93075333094977	0.866036766703064	0.757320665200404	0.737859647931697	0.917112058559895	0.861692724228289	NA	NA	0.870380809177839	0.905887631718924	NA	NA	p.Leu24Ile	1	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.877	-2.76	0.883	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24K	24	L	K	missense	wt-like	1.04968314070517	0.105310979602714	6	0.0429930273898826	0.965418355434654	1.13394792597568	0.91960224506	1.00004030881178	1.07294357460845	1.11374587773557	NA	NA	1.21240068910636	0.979366148908855	0.713523970884679	0.669154560838861	0.673548098922255	0.739562029272915	0.762009308805314	NA	NA	0.735128692777913	0.691919248991446	NA	NA	p.Leu24Lys	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.877	-3.795	1.918	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24L	24	L	L	synonymous	wt-like	1.00396701746258	0.118360513412597	6	0.0483204772591177	0.90926062231892	1.09867341260623	0.981413185734308	0.797201946009744	0.992819993412622	1.07493405835246	NA	NA	1.02846667928642	1.1489662419799	0.706440192644522	0.682320215166063	0.629692057566842	0.715587851689108	0.749154683925973	NA	NA	0.697292533599937	0.730062560473732	NA	NA	p.Leu24=	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24M	24	L	M	missense	wt-like	1.12769468732616	0.218391351926322	6	0.0891578960760128	0.952948422079814	1.30244095257251	0.857557468111758	0.934470025148794	1.06639156601097	1.19786376491937	NA	NA	1.26494548160312	1.44493981816297	0.741769496614914	0.655939099672965	0.659371031861146	0.737601570001099	0.789869478789024	NA	NA	0.745937423228729	0.796627454999749	NA	NA	p.Leu24Met	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.877	-1.478	-0.399	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24N	24	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu24Asn	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.877	-3.321	1.444	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24P	24	L	P	missense	possibly_wt-like	0.730402930987326	0.175299083975425	6	0.0715655513528485	0.590137027801992	0.870668834172661	0.408546488486047	0.913653822103798	0.832197962530501	0.69442826739277	NA	NA	0.733847539405848	0.799743506004996	0.644104866375657	0.560300313361348	0.654870323765336	0.667527330245009	0.623129692442777	NA	NA	0.63668788150589	0.651521851245423	NA	NA	p.Leu24Pro	1	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.877	-3.291	1.414	0.003985873	NA	NA	NA	NA	4.06e-06	NA	NA
L24Q	24	L	Q	missense	possibly_low	0.562353541365324	0.275591159444192	6	0.112509619710045	0.341838738819337	0.78286834391131	0.733786985335718	0.45671931459427	0.157477048482682	0.618735291038276	NA	NA	0.446658347023251	0.960744261717744	0.587835746433114	0.629576139097322	0.556075705325177	0.465640709958312	0.598059885551393	NA	NA	0.577611607314836	0.687731159052008	NA	NA	p.Leu24Gln	1	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.877	-4.139	2.262	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24R	24	L	R	missense	wt-like	1.05146164050864	0.12107840701304	6	0.0494300526751615	0.954580517511401	1.14834276350587	0.92849883491118	0.870259232921175	1.12852930363621	1.16455803504271	NA	NA	1.1008010087928	1.11612342774775	0.717424117634082	0.671049523533066	0.645487902848975	0.756194113347889	0.778838492076673	NA	NA	0.712172072234009	0.722676163034156	NA	NA	p.Leu24Arg	1	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.877	-3.308	1.431	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24S	24	L	S	missense	wt-like	0.932974608644738	0.0681405329517809	6	0.0278182560888611	0.878451828597858	0.987497388691617	0.916061914048563	0.999457980757397	0.925965460127028	1.02156998655924	NA	NA	0.899099837012967	0.835692473363233	0.672051655213017	0.668400474688546	0.673422192743155	0.695583972314892	0.731480296694472	NA	NA	0.670681117682878	0.659606827111783	NA	NA	p.Leu24Ser	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.877	-3.697	1.82	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24T	24	L	T	missense	wt-like	1.29251385637447	0.206957260036565	6	0.0844899476090128	1.12691660200513	1.45811111074381	0.983981994370417	1.08587822205668	1.37476638224634	1.42631393114119	NA	NA	1.50065263118094	1.38348997725126	0.788615437486081	0.682867368245547	0.692107266039992	0.829871941550419	0.865533058520164	NA	NA	0.794423579973446	0.782807294998715	NA	NA	p.Leu24Thr	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.877	-3.661	1.784	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24V	24	L	V	missense	wt-like	0.915024044546591	0.08141175182353	6	0.0332362085056244	0.849882272892904	0.980165816200279	0.804080450556542	0.844889805054846	0.924842106483706	0.967332078666482	NA	NA	0.919705792285614	1.02929403423236	0.68508385764844	0.644548560718195	0.640002733957354	0.695247848051192	0.713516491562858	NA	NA	0.674919867245688	0.703148104159281	NA	NA	p.Leu24Val	1	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.877	-2.151	0.274	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24W	24	L	W	missense	possibly_wt-like	0.827432199420317	0.175225382875243	6	0.0715354630046939	0.687225268313719	0.967639130526914	0.89401362512397	1.05788191373751	0.692146275485368	0.897316662405591	NA	NA	0.560013858199757	0.863220861569706	0.664751109278687	0.663704216270203	0.686054134677248	0.625621764292761	0.690327114560956	NA	NA	0.600929411177068	0.66579800228717	NA	NA	p.Leu24Trp	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.877	-5.388	3.511	0.003985873	NA	NA	NA	NA	NA	NA	NA
L24X	24	L	X	nonsense	possibly_wt-like	0.726522879587234	0.153791591176965	6	0.0627851541857131	0.603466238619442	0.849579520555026	0.958090992308627	0.745311784829149	0.642525470352758	0.750394760539584	NA	NA	0.770264998230687	0.492549271262597	0.630069402849962	0.677352616656075	0.618472793995402	0.610774474938666	0.641666011704521	NA	NA	0.644179137583561	0.582433414033107	NA	NA	p.Leu24Ter	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L24Y	24	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu24Tyr	0	21.6	3.6	5	0.642	17.6	-132	-87.1	151.3	15.7068062827225	-0.9	0	0	14.37	0	0	0	0	3	11.5181705937378	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.877	-4.289	2.412	0.003985873	NA	NA	NA	NA	NA	NA	NA
T25A	25	T	A	missense	possibly_low	0.414019096481852	0.392483938782636	6	0.160230897042535	0.099972309067938	0.728065883895765	0.861984840842713	0.919473418512193	0.0185194337629719	0.335145203201531	NA	NA	0.309915517515725	0.0390761650559759	0.526808331822836	0.656882124618347	0.656128589002901	0.424062506860142	0.504133750250786	NA	NA	0.549482913394887	0.480446642530373	NA	NA	p.Thr25Ala	1	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.844	-2.402	0.558	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25C	25	T	C	missense	possibly_low	0.690789128687513	0.165488038455692	6	0.0675602087917543	0.558373552667668	0.823204704707358	0.664881282042522	0.478067867967806	0.844153221261333	0.519932467226374	NA	NA	0.766418092443573	0.87128184118347	0.629143559301115	0.614899309059885	0.560691513827545	0.671104523021413	0.565336007688704	NA	NA	0.643387809542345	0.66761092851081	NA	NA	p.Thr25Cys	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.844	-5.221	3.377	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25D	25	T	D	missense	wt-like	1.10124299330586	0.181685732365171	2	0.128471213400257	0.849444041991201	1.35304194462053	0.972771779905607	1.22971420670612	NA	NA	NA	NA	NA	NA	0.701842952580856	0.680479606354733	0.723206298806979	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr25Asp	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.844	-2.439	0.595	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25E	25	T	E	missense	wt-like	1.01398645153747	0.167517985774239	6	0.0683889313142828	0.879946609220297	1.14802629385465	1.1551413635992	1.23714830154278	0.911260746086761	1.03732049966579	NA	NA	0.96872794042136	0.774319857908954	0.705254102300192	0.719324103340418	0.724813637606665	0.691184101259967	0.736696927629584	NA	NA	0.685003971876073	0.64580403523021	NA	NA	p.Thr25Glu	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.844	-2.748	0.904	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25F	25	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr25Phe	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.844	-3.64	1.796	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25G	25	T	G	missense	wt-like	0.801380914110851	0.0796980542389908	6	0.0325365943963642	0.737610360914389	0.865151467307312	0.761710240285327	0.957401835801899	0.783563050365988	0.807477684889686	NA	NA	0.746389400870081	0.751743272452123	0.646850781333399	0.635523758051933	0.664329159221594	0.652975034858271	0.660572097304201	NA	NA	0.639267806051728	0.640726527808527	NA	NA	p.Thr25Gly	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.844	-3.639	1.795	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25H	25	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr25His	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.844	-4.856	3.012	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25I	25	T	I	missense	possibly_low	0.65492906530329	0.447618420314616	6	0.182739454873577	0.296766315196597	1.01309181540998	1.14122496255959	1.29507769011169	0.34560309068833	0.397732597616791	NA	NA	0.239048306051639	0.510887744791698	0.560731466104078	0.716359927038173	0.737338653218488	0.521930844231694	0.524862937652231	NA	NA	0.534905168386884	0.586557763821271	NA	NA	p.Thr25Ile	1	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.844	-4.064	2.22	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25K	25	T	K	missense	possibly_low	0.592296846460826	0.412044223393483	2	0.291359264510277	0.0212431814586047	1.16335051146305	0.300937581950549	0.883656110971103	NA	NA	NA	NA	NA	NA	0.592882107101271	0.537379748643857	0.648384465558685	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr25Lys	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.844	-2.919	1.075	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25L	25	T	L	missense	possibly_low	0.719264132021765	0.155646102892021	6	0.0635422554230302	0.594723599896181	0.843804664147349	0.85009970845127	0.862533166157287	0.705683051752623	0.756763717172347	NA	NA	0.707155878180598	0.433349270416466	0.637486353076219	0.654350606039407	0.643817436282241	0.62967217084349	0.643775434805222	NA	NA	0.631197271347215	0.569119246386515	NA	NA	p.Thr25Leu	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.844	-3.205	1.361	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25M	25	T	M	missense	wt-like	0.952251702115308	0.0788603126884877	6	0.0321945878405208	0.889151469450776	1.01535193477984	1.0722031882555	1.00019992226712	0.932346985916482	0.948812134665248	NA	NA	0.837836179479567	0.922111802107933	0.688268041193372	0.701658374018199	0.67358260922988	0.697493420572804	0.707382614390744	NA	NA	0.658078872450862	0.67904266181394	NA	NA	p.Thr25Met	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.844	-3.831	1.987	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25N	25	T	N	missense	possibly_wt-like	1.15660541100502	0.326444672638031	2	0.230831241704574	0.704184490757399	1.60902633125265	NA	NA	1.3874366527096	0.92577416930045	NA	NA	NA	NA	0.766707713805664	NA	NA	0.833663076564451	0.699752351046877	NA	NA	NA	NA	NA	NA	p.Thr25Asn	1	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.844	-2.854	1.01	0.003758957	NA	NA	NA	NA	4.06e-06	NA	NA
T25P	25	T	P	missense	possibly_low	0.682495803370011	0.199441125069198	6	0.0814214983576895	0.522912599021652	0.842079007718369	0.831397423292533	0.838100669851257	0.551283772536837	0.888831371507237	NA	NA	0.594289855560754	0.391071727471446	0.623257500393092	0.650367042307121	0.638534843021227	0.583473590057586	0.687516753355939	NA	NA	0.607980157764957	0.559610964521468	NA	NA	p.Thr25Pro	1	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.844	-3.228	1.384	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25Q	25	T	Q	missense	possibly_wt-like	0.820982480206605	0.269349325757873	6	0.109961401778246	0.605462093031705	1.03650286738151	1.06376312244449	1.08744158073795	0.653669464140402	0.951017181498269	NA	NA	0.780610994374898	0.389392538043621	0.669376322038627	0.69986065038296	0.692445282586921	0.614108925072701	0.708112934440934	NA	NA	0.646307361490333	0.55923331233848	NA	NA	p.Thr25Gln	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.844	-2.569	0.725	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25R	25	T	R	missense	wt-like	0.955578924143099	0.0960645085860346	6	0.0392181714044997	0.878712720650761	1.03244512763544	0.815077342058705	0.982959899744315	1.00503701043509	1.08927772427171	NA	NA	0.882629761600143	0.958491806748629	0.678539846027462	0.646890885080384	0.669855113453027	0.719243366473515	0.753905361624602	NA	NA	0.667293139594416	0.687224578601897	NA	NA	p.Thr25Arg	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.844	-3.229	1.385	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25S	25	T	S	missense	wt-like	1.14671205183873	0.0923749294814583	6	0.0377119070425253	1.07279807224706	1.2206260314304	1.20725650669663	0.98538578093645	1.11276336034962	1.23234878351609	NA	NA	1.13074611213073	1.21177176740284	0.73730609031754	0.730424564710981	0.670379617518313	0.751476706580897	0.801291050492277	NA	NA	0.718331931944587	0.744187615924099	NA	NA	p.Thr25Ser	1	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.844	-2.404	0.56	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25T	25	T	T	synonymous	wt-like	1.0322222896202	0.146539409562152	6	0.0598244634393326	0.914968495884672	1.14947608335572	1.15384970948425	1.21579871797093	0.901060795880669	1.10365422975847	NA	NA	0.966233641392339	0.852736643234528	0.703590552865912	0.719048982602854	0.720197606363297	0.688132123128969	0.758666915915159	NA	NA	0.684490881908688	0.663440086095229	NA	NA	p.Thr25=	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25V	25	T	V	missense	possibly_wt-like	0.724617492079291	0.0855789921396179	6	0.0349374772406194	0.656141294976989	0.793093689181593	0.760076357689635	0.869882485655397	0.700172957056322	0.675161825182332	NA	NA	0.618715069943405	0.723696256948656	0.631221090215281	0.635175743068964	0.645406445655965	0.628023467842686	0.616748572172943	NA	NA	0.613004548307211	0.634418712587876	NA	NA	p.Thr25Val	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.844	-3.086	1.242	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25W	25	T	W	missense	possibly_low	0.654236697292486	0.154602560032746	6	0.0631162308347055	0.530531158016547	0.777942236568425	0.597446442121099	0.88965537534782	0.614055308505372	0.786550609212647	NA	NA	0.468430979876269	0.569281468691709	0.601395773244398	0.60053577111126	0.649681577125613	0.602255775377536	0.653640968799388	NA	NA	0.582090348376137	0.599690598591566	NA	NA	p.Thr25Trp	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.844	-5.597	3.753	0.003758957	NA	NA	NA	NA	NA	NA	NA
T25X	25	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr25Ter	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T25Y	25	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr25Tyr	0	18	4.5	4.5	0.671	16.6	-121.2	-101.5	157.4	33.7423312883436	-2.3	0	0	16.07	1	3	0	0	5	11.4692481805237	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.844	-3.638	1.794	0.003758957	NA	NA	NA	NA	NA	NA	NA
L26A	26	L	A	missense	possibly_wt-like	0.795230445097475	0.165922483165327	6	0.0677375701017638	0.662467247297761	0.927993642897189	0.706589619650451	0.598761961785595	0.992251396788126	0.987509030866499	NA	NA	0.672501842233653	0.813768819260525	0.639372462610045	0.623783133663066	0.586786997426933	0.715417719048432	0.72019917626721	NA	NA	0.624068760303871	0.654676164916219	NA	NA	p.Leu26Ala	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.836	-2.153	0.317	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26C	26	L	C	missense	wt-like	1.10992946366652	0.118769821243867	6	0.0484875764815075	1.01489556006514	1.20496336726791	1.03159180147452	1.10822197920397	1.23402815648936	0.972151167913872	NA	NA	1.04361909728966	1.26996457962776	0.707761027728264	0.69300819859175	0.696938249311352	0.787760952915483	0.715112592583626	NA	NA	0.700409462872902	0.757275265361858	NA	NA	p.Leu26Cys	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.836	-3.906	2.07	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26D	26	L	D	missense	possibly_wt-like	0.849864935955336	0.331424658149257	6	0.135303550107004	0.584674850765196	1.11505502114547	1.34278568492371	1.08875165345854	0.428175591093614	0.679252444439361	NA	NA	0.652612404558488	0.907611837258294	0.647879500172599	0.759292112952795	0.692728535728088	0.546637775183983	0.618103401111887	NA	NA	0.619977402046773	0.675781598298424	NA	NA	p.Leu26Asp	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.836	-4.032	2.196	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26E	26	L	E	missense	wt-like	0.911552409164813	0.126307392237608	6	0.0515647769539522	0.810487303464226	1.0126175148654	0.969777730232714	1.03162125181429	0.8524594846479	1.03682078608681	NA	NA	0.86961154574611	0.709023656461054	0.676715879551322	0.679841877457522	0.680376270493099	0.673589881645122	0.736531420557072	NA	NA	0.664615226533375	0.631118823062348	NA	NA	p.Leu26Glu	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.836	-2.598	0.762	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26F	26	L	F	missense	wt-like	0.943530400782659	0.202181187665878	6	0.0825401242285483	0.781754730015242	1.10530607155008	0.578513145409651	0.964199428572165	0.977203322042938	1.08402746908616	NA	NA	0.895638788811879	1.16160025077316	0.69044213591214	0.596503002202424	0.665798878783179	0.710915109319171	0.752166456775413	NA	NA	0.669969162505109	0.732903967715586	NA	NA	p.Leu26Phe	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.836	-3.587	1.751	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26G	26	L	G	missense	possibly_wt-like	0.75698063165161	0.163884143690629	6	0.0669054214958334	0.625848415149304	0.888112848153915	0.881510033610163	1.01439158103441	0.636965341196074	0.612489188108433	NA	NA	0.77018502816464	0.62634261779594	0.628343211328425	0.661040966658994	0.676651012884901	0.609110800876651	0.595991152072853	NA	NA	0.644162687335174	0.612523735321675	NA	NA	p.Leu26Gly	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.836	-3.833	1.997	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26H	26	L	H	missense	possibly_wt-like	0.969191887241222	0.374227193300071	6	0.152777611909844	0.66975327025389	1.26863050422855	0.762340110364214	0.296764279025898	1.09853006267781	1.19780175593016	NA	NA	1.21572610495915	1.2439890104901	0.741515319034716	0.635657919603905	0.521491544035432	0.747217890376049	0.789848941171663	NA	NA	0.735812747693383	0.751433321489031	NA	NA	p.Leu26His	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.836	-3.878	2.042	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26I	26	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu26Ile	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.836	-2.963	1.127	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26K	26	L	K	missense	possibly_low	0.593686446079184	0.28905185822557	6	0.118004926975992	0.362401039207962	0.824971852950407	0.971544294707545	0.409833245082337	0.480667325824249	0.851966876817353	NA	NA	0.195861077996474	0.652245856047149	0.590346750808752	0.68021815351753	0.545938385268443	0.562344089746218	0.675307089956053	NA	NA	0.526021336425897	0.618349411871286	NA	NA	p.Leu26Lys	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.836	-3.173	1.337	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26L	26	L	L	synonymous	possibly_wt-like	0.820034259432502	0.176222905717017	6	0.0719426999995465	0.679029158482821	0.961039360382183	0.949872732953008	1.01120406005902	0.813584982158177	0.929404836884983	NA	NA	0.606201018950792	0.609937925589034	0.668780092395495	0.67560213752298	0.675961833334312	0.661958047268011	0.700954842210717	NA	NA	0.610430344516508	0.608834295809652	NA	NA	p.Leu26=	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26M	26	L	M	missense	possibly_wt-like	0.766556310358611	0.101933358973193	6	0.0416141195420452	0.684994134807858	0.848118485909364	0.875174799780599	0.875255672155357	0.770190867291374	0.660254695644324	NA	NA	0.636936808259272	0.781525019020742	0.646996339212866	0.659691569646554	0.64656819181728	0.648973877060163	0.611811273141756	NA	NA	0.616752852343499	0.647424486608452	NA	NA	p.Leu26Met	1	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.836	-3.139	1.303	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26N	26	L	N	missense	possibly_wt-like	0.9412859921591	0.29805965960061	6	0.12168234648819	0.702792975487924	1.17977900883028	1.2586874148702	1.10757487187685	0.892802498801539	1.20431793925827	NA	NA	0.607930720727588	0.576402507420158	0.691229726917572	0.741379284884471	0.696798337091062	0.685661116744082	0.792007126324004	NA	NA	0.610786152949224	0.601292130721522	NA	NA	p.Leu26Asn	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.836	-4.239	2.403	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26P	26	L	P	missense	wt-like	1.02842831584927	0.0823781828976307	6	0.0336307523394772	0.962513252490906	1.09434337920763	0.915995458297209	1.10498663016559	1.07983476211041	0.973345251083079	NA	NA	1.11517250205283	0.981235291386485	0.705683545047595	0.668386319695258	0.696238728770632	0.741623975961639	0.715508077553382	NA	NA	0.715128361324558	0.692339621895953	NA	NA	p.Leu26Pro	1	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.836	-2.409	0.573	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26Q	26	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu26Gln	1	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.836	-3.36	1.524	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26R	26	L	R	missense	wt-like	0.793042579459981	0.0700974203881039	6	0.0286171520393702	0.736953992122708	0.849131166797253	0.794688025547206	0.921112623215078	0.790259082258335	0.752489247036923	NA	NA	0.712566247411539	0.787140251290804	0.645617673193318	0.642547985745252	0.656483004352377	0.654978588060687	0.642359713743387	NA	NA	0.632310211752494	0.648687360641384	NA	NA	p.Leu26Arg	1	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.836	-4.193	2.357	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26S	26	L	S	missense	possibly_low	0.64014967111403	0.287815897122837	6	0.117500347968721	0.409853220924412	0.870446121303648	1.10262342752783	0.834648474257183	0.65714973379522	0.389440220848285	NA	NA	0.498368304990509	0.358667865265158	0.601699441017182	0.708137847561897	0.637788437702976	0.615150273967732	0.522116470354084	NA	NA	0.588248608066632	0.552323288040974	NA	NA	p.Leu26Ser	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.836	-3.274	1.438	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26T	26	L	T	missense	possibly_wt-like	0.742441972478877	0.270702439980785	6	0.110513808346552	0.525838888325273	0.959045056632481	0.91593214923695	1.02928980191527	0.937169300863048	0.60816586937333	NA	NA	0.305328625024642	0.658766088460018	0.644094328358298	0.668372834943302	0.679872183584799	0.698936329553762	0.594559252165636	NA	NA	0.548539366333662	0.619815821773294	NA	NA	p.Leu26Thr	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.836	-2.831	0.995	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26V	26	L	V	missense	possibly_wt-like	0.764276059925831	0.279425764257622	6	0.114075090569733	0.54069299087601	0.987859128975652	1.06111585271614	1.14231393520647	0.482546100939711	0.51577023076938	NA	NA	0.629586308466538	0.75432393145675	0.628273869533853	0.699296785187347	0.704309331446303	0.562906247447931	0.563957458855792	NA	NA	0.615240817236626	0.641306921831081	NA	NA	p.Leu26Val	1	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.836	-2.421	0.585	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26W	26	L	W	missense	possibly_low	0.657838890945113	0.20506844583995	6	0.0837188424422409	0.493752974930937	0.821924806959288	0.775054556477756	0.939654143706172	0.466174758369621	0.391276692845515	NA	NA	0.748932104556743	0.625941089714868	0.62539975602427	0.638366080985475	0.660491899308029	0.55800769613254	0.522724716991346	NA	NA	0.639790853102815	0.612433431063064	NA	NA	p.Leu26Trp	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.836	-5.582	3.746	0.003591061	NA	NA	NA	NA	NA	NA	NA
L26X	26	L	X	nonsense	possibly_low	0.581767077076739	0.276149762091914	6	0.112737668286026	0.360805307535104	0.802728846618373	0.909687311940297	0.784357356567659	0.432995884087979	0.299817549775076	NA	NA	0.782981268322414	0.280763091767007	0.587497492660424	0.667042692281171	0.626914906154339	0.548080079166508	0.492433094628801	NA	NA	0.646794938869097	0.534802389392338	NA	NA	p.Leu26Ter	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L26Y	26	L	Y	missense	possibly_wt-like	0.798176521165561	0.165938049528354	6	0.0677439250428583	0.665400867910177	0.930952174420944	0.89183465545435	0.958342331635713	0.796187970379029	0.916037887735127	NA	NA	0.715844346937478	0.510811934851668	0.659996349374114	0.663240098411023	0.664532505490083	0.656752600337206	0.69652765688847	NA	NA	0.632984533459426	0.586540714053764	NA	NA	p.Leu26Tyr	0	15.7	6.6	6.7	0.879	115.3	56.5	-61.5	-35.4	36.6492146596859	-3.3	1	0	15.26	0	0	0	0	5	9.372702104278	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.836	-3.626	1.79	0.003591061	NA	NA	NA	NA	NA	NA	NA
E27A	27	E	A	missense	wt-like	1.32522291818914	0.151108698374766	6	0.0616898677857178	1.2043129991181	1.44613283726019	1.26701530087652	1.3215260534409	1.32095613804939	1.35358630534581	NA	NA	1.57782537437242	1.11042833704983	0.776725759606993	0.743153114359309	0.743057100655776	0.813771109174332	0.841445387217344	NA	NA	0.810298404854677	0.721395328722823	NA	NA	p.Glu27Ala	1	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.383	-2.565	1.182	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27C	27	E	C	missense	possibly_low	0.571428269344705	0.343503908513996	6	0.140234883418494	0.296572948468283	0.846283590221127	1.0409962618856	0.868676946859331	0.548250908204417	0.491874452964437	NA	NA	0.0754449401651808	0.40332610598926	0.572466551950481	0.695011337090459	0.645145793979598	0.582566111547417	0.556043084709851	NA	NA	0.501251125832205	0.562366992353546	NA	NA	p.Glu27Cys	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.383	-5.45	4.067	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27D	27	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu27Asp	1	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.383	-2.077	0.694	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27E	27	E	E	synonymous	wt-like	0.945493945797456	0.132719051413572	6	0.0541823258515764	0.839298538529753	1.05168935306516	0.897264337532589	0.747903813233614	1.07586952030299	1.08568054554658	NA	NA	1.00293537212937	0.863310086039593	0.678929341581736	0.664396614014391	0.619033221043473	0.740437516122536	0.75271396210068	NA	NA	0.692040614161212	0.665818069002259	NA	NA	p.Glu27=	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27F	27	E	F	missense	possibly_wt-like	0.852062088580012	0.209388980341741	6	0.0854826932664874	0.684519088476212	1.01960508868381	0.534217324355586	0.708816086239584	1.11625474693016	0.922358795734295	NA	NA	1.00173601694527	0.828989561275175	0.674946616497382	0.587068046808196	0.610581994422144	0.752521381826891	0.698621166095654	NA	NA	0.691793900713812	0.658099332280951	NA	NA	p.Glu27Phe	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.383	-4.667	3.284	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27G	27	E	G	missense	wt-like	0.947531473115731	0.142543269390024	6	0.058193046045607	0.83347519871566	1.0615877475158	1.02331086103507	1.03205793299388	0.970325832771373	1.09621069155737	NA	NA	0.707339022543934	0.855944497792761	0.685857527284288	0.691244368464904	0.680470686103671	0.708857261346497	0.756201587237684	NA	NA	0.631234945072104	0.664161537324346	NA	NA	p.Glu27Gly	1	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.383	-2.583	1.2	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27H	27	E	H	missense	wt-like	1.32382777584604	0.289454756047857	2	0.204675420848138	0.922671322463107	1.72498422922896	1.52850319669417	1.1191523549979	NA	NA	NA	NA	NA	NA	0.749075619852046	0.798849714500414	0.699301525203677	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu27His	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.383	-4.795	3.412	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27I	27	E	I	missense	wt-like	0.963260665328292	0.145483523349349	6	0.0593933996980314	0.846851741000758	1.07966958965583	0.740160969760844	0.870608194315525	0.950550198939866	1.15967984976967	NA	NA	1.03146586866563	1.02709891051822	0.700281949833745	0.630933789938948	0.645563352409554	0.70294009501128	0.77722281822336	NA	NA	0.69790948207438	0.70265441759311	NA	NA	p.Glu27Ile	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.383	-4.31	2.927	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27K	27	E	K	missense	possibly_low	0.617805006648924	0.173689512458338	5	0.0776763113671281	0.465562233917434	0.770047779380414	0.888669669902306	0.553377096521096	0.412553526651034	NA	NA	NA	0.594577296949191	0.639847443220993	0.608039285917156	0.662565960381829	0.576974255397002	0.541963419125724	NA	NA	NA	0.608039285917156	0.615560990510479	NA	NA	p.Glu27Lys	1	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.383	-2.761	1.378	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27L	27	E	L	missense	possibly_wt-like	0.988269618586136	0.345831465024075	6	0.141185104384692	0.711551898838612	1.26498733833366	0.58887739511709	0.539547723808584	1.28789539886442	1.08832145615342	NA	NA	1.34813059459468	1.07684514297862	0.733715530342166	0.598710574640578	0.573984182250971	0.803878840001599	0.753588641920654	NA	NA	0.763049023087113	0.713842418763678	NA	NA	p.Glu27Leu	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.383	-3.905	2.522	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27M	27	E	M	missense	possibly_wt-like	0.732233685353398	0.314003453922389	6	0.128191373263564	0.480983210628083	0.983484160078714	1.0397799071408	1.10821857487461	0.777058142250272	0.66784428480901	NA	NA	0.276839161708465	0.523662041337233	0.6326768216106	0.69475225502611	0.696937513255277	0.651028668757243	0.614324974463957	NA	NA	0.542678939162085	0.58943072198586	NA	NA	p.Glu27Met	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.383	-5.048	3.665	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27N	27	E	N	missense	wt-like	0.992882160539186	0.122994758315139	6	0.0502123998181714	0.894467665318245	1.09129665576013	1.15846126056532	1.04029672835665	1.0897436402645	0.848781947105235	NA	NA	0.8776812778347	0.942328109108711	0.682920674876041	0.720031237310246	0.68225201062807	0.744588860967738	0.674252228901687	NA	NA	0.66627521137319	0.683589339124012	NA	NA	p.Glu27Asn	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.383	-3.147	1.764	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27P	27	E	P	missense	possibly_low	0.720180349659605	0.188016272361695	6	0.0767573217710501	0.569738763438595	0.870621935880616	0.469008122086837	0.953818699322465	0.644280220484871	0.903556039771425	NA	NA	0.5867674352359	0.763651581056133	0.627352123255181	0.573178566941734	0.663554442942812	0.611299522504621	0.692393620506651	NA	NA	0.606432757732231	0.64340472400574	NA	NA	p.Glu27Pro	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.383	-3.231	1.848	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27Q	27	E	Q	missense	possibly_wt-like	0.873766935444057	0.295850014582765	6	0.120780262687123	0.63704197053401	1.1104919003541	0.364762903195994	0.853167019220313	0.827368026496903	1.22131121570063	NA	NA	1.10859918422901	0.867393263821489	0.666409261318984	0.55097446355473	0.64179236507907	0.666082140920472	0.797635365288563	NA	NA	0.713776196492439	0.666736381717496	NA	NA	p.Glu27Gln	1	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.383	-2.761	1.378	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27R	27	E	R	missense	wt-like	0.887564260732293	0.0774302511859093	6	0.031610767676835	0.825608294562034	0.949520226902552	0.928860428915735	1.01143465016836	0.808299242885666	0.904238065360045	NA	NA	0.85979426968299	0.812758907380961	0.666861152820727	0.671126542611224	0.676011689629896	0.660376474775998	0.692619510022761	NA	NA	0.66259576303023	0.65444903424256	NA	NA	p.Glu27Arg	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.383	-3.418	2.035	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27S	27	E	S	missense	wt-like	1.11779743090567	0.107911397825494	6	0.0440546436838239	1.03145191593363	1.20414294587771	1.18486879599196	1.18410496139172	1.08233695094582	1.23654160615958	NA	NA	1.08192346206328	0.937008808881651	0.719500526520213	0.725656009871019	0.713345043169407	0.742372668401406	0.802679729588602	NA	NA	0.708288865079187	0.682393020644731	NA	NA	p.Glu27Ser	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.383	-2.867	1.484	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27T	27	E	T	missense	wt-like	0.984082941163219	0.226771054617969	6	0.0925788953744733	0.802631640500749	1.16553424182569	0.727263896161968	1.18622044714007	1.30149850320462	0.958618826895999	NA	NA	0.967331248230781	0.763564725345881	0.697673647019639	0.628186729127659	0.713802436086528	0.80794909290687	0.710630628834207	NA	NA	0.684716665205071	0.643385190028192	NA	NA	p.Glu27Thr	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.383	-3.109	1.726	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27V	27	E	V	missense	wt-like	0.824091944721391	0.110557992399605	6	0.0451351113942556	0.735628751950447	0.912555137492336	0.909433690541092	0.991186961601679	0.740199298690025	0.68890393651253	NA	NA	0.811958203638988	0.802869577344035	0.652490275406259	0.666988671235132	0.67163390105546	0.63999994977266	0.621300012662144	NA	NA	0.652755641504793	0.652224909307726	NA	NA	p.Glu27Val	1	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.383	-3.381	1.998	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27W	27	E	W	missense	wt-like	0.839777259432792	0.0626679373716006	6	0.0255840782988524	0.789633387389389	0.889921131476196	0.878538316312564	0.890233896013167	0.868968940807901	0.726234513560495	NA	NA	0.807077554960477	0.867610334942149	0.656079830917711	0.660407994530249	0.649806660102393	0.678529758618726	0.63366404434394	NA	NA	0.651751667305173	0.666785201333212	NA	NA	p.Glu27Trp	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.383	-5.741	4.358	0.004716147	NA	NA	NA	NA	NA	NA	NA
E27X	27	E	X	nonsense	low	0.445391688143057	0.259701525887799	6	0.106022703974551	0.237591006809386	0.653192369476728	0.529488677843497	0.839338036263887	0.589343463498844	0.345211710644541	NA	NA	0.247945622163372	0.1210226184442	0.561398121188905	0.586060850918042	0.638802376202891	0.594861620601028	0.50746781649869	NA	NA	0.536735391459767	0.498876520957069	NA	NA	p.Glu27Ter	1	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E27Y	27	E	Y	missense	wt-like	1.011842930823	0.330398153029045	5	0.147758545962665	0.722241502328168	1.30144435931783	1.4117509234889	1.13597161978793	1.15715029818506	NA	NA	NA	0.587191839019202	0.767149973633897	0.702938048206574	0.773981623929928	0.702938048206574	0.764757944316232	NA	NA	NA	0.606520059744058	0.644191517664663	NA	NA	p.Glu27Tyr	0	13.4	3.6	7.1	0.892	103	54.6	-64.1	-41	54.2056074766355	-3.5	1	0	18.08	0	0	0	0	7	11.8569710684203	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.383	-4.611	3.228	0.004716147	NA	NA	NA	NA	NA	NA	NA
E28A	28	E	A	missense	wt-like	0.927825001637964	0.156744157012398	6	0.063990534140511	0.802405859371082	1.05324414390485	0.637661857578295	0.934875628499268	0.996616963027229	0.888082828347036	NA	NA	1.0574624004704	1.05225033190555	0.695262966773208	0.609101605132847	0.65945872807929	0.71672396196354	0.687268832962529	NA	NA	0.703257100583886	0.708311009419374	NA	NA	p.Glu28Ala	1	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.998	-3.604	1.606	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28C	28	E	C	missense	wt-like	1.16053985373568	0.128240596844248	6	0.0523540044297299	1.05792789060695	1.2631518168644	1.1811777654604	0.981827091792435	1.20687633458261	1.03898260870646	NA	NA	1.22367400105651	1.33070132081564	0.737347547415982	0.724869824908299	0.669610187041183	0.779636720443578	0.737247424580408	NA	NA	0.737447670251556	0.770935048181541	NA	NA	p.Glu28Cys	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.998	-5.415	3.417	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28D	28	E	D	missense	wt-like	1.39265561450579	0.09107198497383	4	0.045535992486915	1.30340670923115	1.48190451978043	1.25791478554281	1.45834232615392	1.43094091113976	1.42342443518668	NA	NA	NA	NA	0.809659296231072	0.741214715788183	0.772638389083211	0.846680203378934	0.864576046270391	NA	NA	NA	NA	NA	NA	p.Glu28Asp	1	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.998	-2.152	0.154	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28E	28	E	E	synonymous	wt-like	1.07876165065472	0.162778827034068	6	0.0664541778603711	0.948513855426171	1.20900944588326	0.790348175118273	1.15209192352094	1.2623626643608	1.03974162856412	NA	NA	1.16972584092721	1.05829967143697	0.718010887387073	0.641623602942536	0.706423447602478	0.796239062771799	0.737498814896587	NA	NA	0.726350259957454	0.709671514816693	NA	NA	p.Glu28=	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28F	28	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu28Phe	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.998	-1.755	-0.243	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28G	28	E	G	missense	wt-like	1.07176309697063	0.0759440807116806	6	0.0310040411213932	1.0109962929975	1.13252990094375	1.05401294150603	0.959365392400312	1.14624477905989	1.06305085520726	NA	NA	1.16795812835144	1.03994648529883	0.715765244325763	0.697783873837205	0.664753703268361	0.761494849379033	0.745218921026306	NA	NA	0.725986632510504	0.705543856141021	NA	NA	p.Glu28Gly	1	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.998	-3.09	1.092	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28H	28	E	H	missense	wt-like	0.988614507478132	0.167058707755444	6	0.068201431848262	0.854942157361475	1.12228685759479	0.957468485202031	0.878974579624769	1.00002388227784	1.0047130756918	NA	NA	1.28994390676242	0.800563115309929	0.697481693362651	0.677220023408144	0.647372263382059	0.717743363317158	0.725897222536407	NA	NA	0.751079726136451	0.651706182588914	NA	NA	p.Glu28His	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.998	-3.777	1.779	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28I	28	E	I	missense	possibly_low	0.666624516774879	0.212175246646129	6	0.0866201817220307	0.496852080265384	0.836396953284373	0.714329837348018	0.630294796186053	0.706117327643734	0.996190443671398	NA	NA	0.615973649861993	0.336841045938076	0.618936207398206	0.625431790511057	0.593604767351794	0.629802112705529	0.723074493807162	NA	NA	0.612440624285354	0.547414404129502	NA	NA	p.Glu28Ile	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.998	-4.098	2.1	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28K	28	E	K	missense	wt-like	1.17928067897541	0.193544336735214	6	0.0790141446011134	1.02441580128799	1.33414555666283	1.07594063026603	0.939328650911718	1.07667712715597	1.16102621885542	NA	NA	1.42656334290361	1.3961481037597	0.75917395254392	0.702454444568845	0.660421523934962	0.740679164209435	0.777668740878406	NA	NA	0.779183037414794	0.785654126350343	NA	NA	p.Glu28Lys	1	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.998	-3.144	1.146	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28L	28	E	L	missense	wt-like	0.903373388021746	0.147181894255081	6	0.06008675671687	0.78560550890886	1.02114126713463	0.678263519717478	0.91949711365319	1.07751252576809	0.935146266732384	NA	NA	0.790806458202666	1.01901444405666	0.678484960656985	0.617749709222557	0.656133712171266	0.740929128007624	0.702856426009994	NA	NA	0.648404620135748	0.700836209142705	NA	NA	p.Glu28Leu	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.998	-3.231	1.233	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28M	28	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu28Met	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.998	-3.872	1.874	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28N	28	E	N	missense	possibly_low	0.584403308594796	0.399934281681748	6	0.163272486794467	0.26439511481135	0.904411502378242	1.06486310282856	0.847805132153216	0.73315223351986	0.655408975317212	NA	NA	0.166112393957371	0.0390780137925542	0.62404885697562	0.700094944851632	0.640633061988129	0.637891362146985	0.610206351804254	NA	NA	0.519901881161802	0.480447058313961	NA	NA	p.Glu28Asn	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.998	-3.234	1.236	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28P	28	E	P	missense	low	0.507749464581249	0.221120489843519	6	0.0902720619651487	0.33081947431939	0.684679454843109	0.784841723487097	0.689748359557816	0.381440148684785	0.43010825948472	NA	NA	0.180132820829248	0.58022547544383	0.568868902058051	0.640450735518829	0.606459327494855	0.532653829645793	0.535585882238377	NA	NA	0.522785954114851	0.602151921877725	NA	NA	p.Glu28Pro	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.998	-4.306	2.308	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28Q	28	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu28Gln	1	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.998	-2.842	0.844	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28R	28	E	R	missense	wt-like	0.850364448972833	0.127628188369416	6	0.0521039897168138	0.748242505677032	0.952486392268633	0.932232786411837	1.02184206599432	0.872078240429276	0.767049311971708	NA	NA	0.853340200137766	0.655644088892088	0.666556489391768	0.671844850609404	0.678261895422139	0.679460107714105	0.647182063633971	NA	NA	0.661268128174132	0.61911367945833	NA	NA	p.Glu28Arg	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.998	-3.516	1.518	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28S	28	E	S	missense	possibly_wt-like	0.83773524945497	0.20970570642225	6	0.0856119961474004	0.669938820361483	1.00553167854846	1.08624452825815	1.09684060236838	0.83912577827585	0.659289377635188	NA	NA	0.719944480382484	0.624966729809774	0.651714094184269	0.704649162165877	0.694477461685737	0.669600236653685	0.611491556078914	NA	NA	0.633827951714854	0.612214296080984	NA	NA	p.Glu28Ser	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.998	-3.73	1.732	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28T	28	E	T	missense	possibly_wt-like	0.79910859717118	0.122223697495348	6	0.0498976155566483	0.701311067765724	0.896906126576636	0.883182313725419	0.964407839228855	0.629537606402706	0.829290151914405	NA	NA	0.696223740708076	0.792009931047621	0.655589859539539	0.661397160266396	0.665843939620056	0.606888311188547	0.667796470852063	NA	NA	0.628948475194884	0.649782558812682	NA	NA	p.Glu28Thr	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.998	-3.026	1.028	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28V	28	E	V	missense	wt-like	0.964319822431121	0.0926664461965225	6	0.0378309182430919	0.890172585172581	1.03846705968966	0.877478727344561	0.99608917189567	0.99915812590802	1.11464136104128	NA	NA	0.866772273525543	0.931779274871647	0.676955353669071	0.660182303383512	0.672693816617863	0.71748431602241	0.762305896343944	NA	NA	0.66403117382995	0.681216890720279	rs72552742	*13	p.Glu28Val	1	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.998	-3.856	1.858	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28W	28	E	W	missense	wt-like	0.968712773857907	0.0892234844378261	6	0.0364253349909716	0.897320429150796	1.04010511856502	1.0948887753335	0.935706463938405	0.876293287522142	1.04462355849616	NA	NA	0.877694098701675	0.98307045915556	0.686736833440372	0.706490376159249	0.659638364479797	0.680721313042428	0.739115728995464	NA	NA	0.666277848690585	0.692752353838315	NA	NA	p.Glu28Trp	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.998	-5.277	3.279	0.003499527	NA	NA	NA	NA	NA	NA	NA
E28X	28	E	X	nonsense	wt-like	1.00183796817049	0.135465126206565	6	0.0553034061913015	0.893445283813147	1.11023065252783	1.18601775887585	0.999138238875285	1.01877534643467	0.766662698599714	NA	NA	0.992336181739725	1.04809758449768	0.698618678652911	0.725900737551896	0.673353060785022	0.723354082720147	0.647054015787997	NA	NA	0.689860306913341	0.707377050392481	NA	NA	p.Glu28Ter	1	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E28Y	28	E	Y	missense	wt-like	1.16748073127907	0.163223001903275	2	0.115416091491431	0.941269348719487	1.39369211383865	1.05206463978764	1.2828968227705	NA	NA	NA	NA	NA	NA	0.716036947151898	0.697368887967882	0.734705006335914	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu28Tyr	0	16.3	1.6	8.5	0.925	110.6	46	-57.7	-46.4	43.9252336448598	-2.3	1	0	16.72	1	3	0	0	7	11.2048601147039	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.998	-2.564	0.566	0.003499527	NA	NA	NA	NA	NA	NA	NA
W29A	29	W	A	missense	possibly_wt-like	0.758371636314774	0.0969350527839982	6	0.0395735695850916	0.680808865188305	0.835934407441243	0.633282111146051	0.846957107937922	0.850303216117394	0.643249483607195	NA	NA	0.787512699236134	0.788925199843948	0.644088393187168	0.608168724530502	0.640449709171914	0.672944693750407	0.606179081061988	NA	NA	0.647727077202423	0.649088798207895	NA	NA	p.Trp29Ala	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	148	-0.9	1.8	-2.7	264	121	143	5.4	8.1	-2.7	204	89	115	5.89	6	0.11	-0.563	-3.788	3.225	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29C	29	W	C	missense	possibly_low	0.647928888614526	0.17277632908111	6	0.0705356409799852	0.509681572667308	0.786176204561745	0.676511914732436	0.907372393700331	0.765391934925047	0.604072798827954	NA	NA	0.470279490445752	0.463944799055639	0.605290115432985	0.617376619515471	0.653512205014879	0.64753796449802	0.593203611350499	NA	NA	0.582470596380395	0.57600022597631	NA	NA	p.Trp29Cys	1	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	215	-0.9	2.5	-3.4	264	148	116	5.4	5.5	-0.0999999999999996	204	121	83	5.89	5.07	-0.82	-0.563	-5.122	4.559	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29D	29	W	D	missense	possibly_wt-like	0.727159823933091	0.267637312948856	6	0.109262475475713	0.513009307139003	0.941310340727178	0.303705965352091	0.528045146529518	0.905684033693894	1.03466531721117	NA	NA	0.753975151405248	0.836883329406621	0.650351442912638	0.537969410902872	0.571497189663001	0.689515465244888	0.73581752091836	NA	NA	0.64082823343008	0.659874652395196	NA	NA	p.Trp29Asp	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	181	-0.9	-3.5	2.6	264	187	77	5.4	13	-7.6	204	133	71	5.89	5.05	-0.84	-0.563	-4.404	3.841	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29E	29	W	E	missense	wt-like	0.840278959085101	0.09618324214018	6	0.0392666441750003	0.763317750708351	0.917240167461851	0.881675658027325	0.931176295997442	0.927269712081038	0.714724490567963	NA	NA	0.858820471573414	0.728007126263425	0.6598675666545	0.661076244456107	0.658658888852892	0.695974224067157	0.629851880155987	NA	NA	0.662395447817632	0.635388233465225	NA	NA	p.Trp29Glu	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	152	-0.9	-3.5	2.6	264	214	50	5.4	12.3	-6.9	204	147	57	5.89	3.22	-2.67	-0.563	-4.15	3.587	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29F	29	W	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp29Phe	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	40	-0.9	2.8	-3.7	264	228	36	5.4	5.2	0.2	204	165	39	5.89	3.32	-2.57	-0.563	-3.652	3.089	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29G	29	W	G	missense	possibly_low	0.67887182829268	0.112966883145344	6	0.0461185369231175	0.588481156903689	0.769262499681671	0.785611886455976	0.815699124565828	0.680391521492302	0.686424261427138	NA	NA	0.523228615397551	0.581875560417286	0.621291650106661	0.640614779283788	0.633691365274259	0.622104565542058	0.620478734671264	NA	NA	0.593362500068963	0.60252302842593	NA	NA	p.Trp29Gly	1	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	184	-0.9	-9.4	8.5	264	97	167	5.4	9	-3.6	204	75	129	5.89	3.29	-2.6	-0.563	-3.618	3.055	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29H	29	W	H	missense	possibly_wt-like	0.883678219155958	0.295093809534018	6	0.120471543268732	0.647558333187285	1.11979810512463	0.661673616453283	1.2866862766318	0.494672272756016	0.758759950021765	NA	NA	1.02413929816077	1.07613790091212	0.670419482099428	0.614216080235271	0.735524330860919	0.56653457998371	0.644436594855407	NA	NA	0.696402369343449	0.713683358978111	NA	NA	p.Trp29His	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	115	-0.9	-3.2	2.3	264	216	48	5.4	10.4	-5	204	155	49	5.89	7.59	1.7	-0.563	-4.94	4.377	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29I	29	W	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp29Ile	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	61	-0.9	4.5	-5.4	264	191	73	5.4	5.2	0.2	204	131	73	5.89	6.02	0.13	-0.563	-4.27	3.707	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29K	29	W	K	missense	possibly_low	0.343020550257584	0.527774681104095	6	0.215463111310857	-0.0792793879086406	0.765320488423809	0.538291637131698	0.821530137547996	0.522427741817194	0.801206498513032	NA	NA	-0.203908819023144	-0.421423894441271	0.581387651579109	0.587935870417512	0.634952098909442	0.574839432740706	0.65849505609094	NA	NA	0.443786640009474	0.376879498851644	NA	NA	p.Trp29Lys	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	110	-0.9	-3.9	3	264	230	34	5.4	11.3	-5.9	204	146	58	5.89	9.74	3.85	-0.563	-4.167	3.604	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29L	29	W	L	missense	possibly_low	0.622895163978231	0.262904016396642	6	0.107330115250013	0.412532003631673	0.833258324324789	0.770757950005057	1.00260407065212	0.761030408800062	0.473033284739866	NA	NA	0.315161184850247	0.414784084822041	0.601197408906089	0.63745090909224	0.674102414406477	0.646232930445669	0.54980281683102	NA	NA	0.550561973784306	0.564943908719937	NA	NA	p.Trp29Leu	1	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	61	-0.9	3.8	-4.7	264	191	73	5.4	4.9	0.5	204	131	73	5.89	9.71	3.82	-0.563	-3.618	3.055	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29M	29	W	M	missense	possibly_low	0.510178866133405	0.398734244535178	6	0.162782573680886	0.19113088440813	0.829226847858679	0.0323601156712333	0.0209971364533756	0.810952221401124	0.92947914585548	NA	NA	0.757278239461697	0.510006337957519	0.61393361476335	0.480173078715618	0.461867442154229	0.661170285750325	0.700979453629509	NA	NA	0.64150769540454	0.58635953412216	NA	NA	p.Trp29Met	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	67	-0.9	1.9	-2.8	264	203	61	5.4	5.7	-0.3	204	149	55	5.89	5.74	-0.15	-0.563	-4.74	4.177	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29N	29	W	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp29Asn	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	174	-0.9	-3.5	2.6	264	187	77	5.4	11.6	-6.2	204	132	72	5.89	5.47	-0.42	-0.563	-4.608	4.045	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29P	29	W	P	missense	possibly_low	0.705853225552816	0.120337841807637	6	0.0491277181960784	0.609564667245869	0.802141783859763	0.609635343277171	0.92544376452168	0.655188895168653	0.669223715810493	NA	NA	0.759816106540995	0.615811527997906	0.614672704492913	0.603131992063386	0.657419448078478	0.614563561632301	0.614781847353526	NA	NA	0.64202974754095	0.610155277668494	NA	NA	p.Trp29Pro	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	147	-0.9	-1.6	0.7	264	154	110	5.4	8	-2.6	204	115	89	5.89	6.3	0.41	-0.563	-4.589	4.026	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29Q	29	W	Q	missense	possibly_wt-like	0.773690897729442	0.194909474119924	6	0.0795714596046694	0.617733702707007	0.929648092751878	0.911499933988756	1.08154601627856	0.768679588605548	0.561983703321685	NA	NA	0.608575668837959	0.709860475344143	0.639914352334558	0.667428778547705	0.691170592162621	0.648521679803727	0.579263539927841	NA	NA	0.610918822048264	0.631307024865389	NA	NA	p.Trp29Gln	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	130	-0.9	-3.5	2.6	264	214	50	5.4	10.5	-5.1	204	146	58	5.89	6.24	0.35	-0.563	-4.384	3.821	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29R	29	W	R	missense	possibly_low	0.621136247892862	0.155360893786515	6	0.0634258192932827	0.496823926388083	0.745448569397642	0.709879526195314	0.872305419974342	0.579228384992561	0.573564249264679	NA	NA	0.411226065444836	0.580613841485443	0.597037151665079	0.62448387971006	0.645930312572584	0.591835037355939	0.583099061590089	NA	NA	0.570323007195955	0.602239265974218	NA	NA	p.Trp29Arg	1	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	101	-0.9	-4.5	3.6	264	265	-1	5.4	10.5	-5.1	204	174	30	5.89	6.34	0.45	-0.563	-4.418	3.855	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29S	29	W	S	missense	possibly_wt-like	0.723773821232699	0.054807962877751	6	0.0223752571486487	0.679919123076525	0.767628519388873	0.765315875093517	0.735174717286746	0.726210468366148	0.620004407872747	NA	NA	0.772657043877116	0.72328041489992	0.635069735481418	0.636291753830624	0.616281040683943	0.635814281866045	0.598480221961653	NA	NA	0.644671193511271	0.634325189096791	NA	NA	p.Trp29Ser	1	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	177	-0.9	-0.8	-0.1	264	143	121	5.4	9.2	-3.8	204	105	99	5.89	5.68	-0.21	-0.563	-4.096	3.533	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29T	29	W	T	missense	possibly_wt-like	0.760387133030257	0.137796374735555	6	0.0562551344179082	0.650129095625698	0.870645170434817	0.949276635438027	0.805470121393762	0.712974176380219	0.711062317815199	NA	NA	0.544919723184358	0.838619823969979	0.631666759559032	0.675475169485575	0.631479734397626	0.631853784720439	0.628638954358424	NA	NA	0.597824471010453	0.660265192587822	NA	NA	p.Trp29Thr	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	128	-0.9	-0.7	-0.2	264	163	101	5.4	8.6	-3.2	204	119	85	5.89	5.6	-0.29	-0.563	-3.906	3.343	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29V	29	W	V	missense	possibly_low	0.639804423624888	0.176312751702345	6	0.0719793794694619	0.498727432235201	0.780881415014575	0.800118266137181	0.904904587225855	0.497127743988	0.464585209464539	NA	NA	0.622196626509745	0.549894108424005	0.604525537393074	0.643704620310933	0.652978636210109	0.567269293815629	0.547004781584468	NA	NA	0.61372072215978	0.595330352626368	NA	NA	p.Trp29Val	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	88	-0.9	4.2	-5.1	264	165	99	5.4	5.9	-0.5	204	117	87	5.89	5.61	-0.28	-0.563	-4.013	3.45	0.001931839	NA	NA	NA	NA	NA	NA	NA
W29X	29	W	X	nonsense	low	0.264394656589145	0.423125223139402	8	0.149597357286471	-0.0288107758747088	0.557600089052999	-0.14735228836389	-0.13837118311523	-0.0336603281170312	0.375799869673028	0.825522955130425	0.943159660352168	0.0551464844159069	0.234912082737785	0.507337181852001	0.441894557728472	0.427410135769022	0.408449539255329	0.517598733222268	0.626689964805807	0.661223388725297	0.497075630481734	0.524490429725865	NA	NA	p.Trp29Ter	1	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	NA	-0.9	NA	NA	264	NA	NA	5.4	NA	NA	204	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
W29Y	29	W	Y	missense	low	0.569035832840673	0.156524741904319	6	0.0639009582977355	0.443792255999516	0.694279409681831	0.78121586612675	0.741161819052887	0.533081986521896	0.404725920348477	NA	NA	0.440779021059354	0.513250383934675	0.582558233728152	0.639678432361406	0.617575522551317	0.578027342601445	0.527179153222767	NA	NA	0.576402200129906	0.587089124854859	NA	NA	p.Trp29Tyr	0	16.9	4.3	11.1	0.915	112.5	49.2	-62.3	-45.1	17.8030303030303	-3.6	1	0	14.13	0	0	0	0	7	7.62899130763044	37	-0.9	-1.3	0.4	264	255	9	5.4	6.2	-0.8	204	181	23	5.89	5.66	-0.23	-0.563	-3.522	2.959	0.001931839	NA	NA	NA	NA	NA	NA	NA
Q30A	30	Q	A	missense	wt-like	0.984343325675273	0.0794757699117889	6	0.0324458471997872	0.9207506337158	1.04793601763475	0.829217810853719	1.00922640746209	1.02394398208308	1.05326904171088	NA	NA	0.982083868697395	1.00831884324446	0.693091053407709	0.649902787538893	0.675534241566763	0.72490061605093	0.741979146516011	NA	NA	0.687751354096014	0.698430752719405	NA	NA	p.Gln30Ala	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.179	-3.247	1.068	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30C	30	Q	C	missense	wt-like	1.0837891433591	0.106047210214954	6	0.0432935922787169	0.998935261731457	1.16864302498675	1.11097648541784	1.02877274279862	0.93006208100946	1.04553411326116	NA	NA	1.2337582309473	1.15363120672023	0.720514378276196	0.709917038616996	0.679760389318222	0.69680974274431	0.739417308259777	NA	NA	0.739522047511688	0.731111717935396	NA	NA	p.Gln30Cys	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.179	-4.323	2.144	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30D	30	Q	D	missense	wt-like	1.05770619425601	0.212150176093698	6	0.0866099467118599	0.887953817997831	1.22745857051419	0.881198907533165	1.002877361694	1.18053546414863	1.02877994258471	NA	NA	0.838751250958013	1.41409423861753	0.704014882598538	0.660974697187323	0.674161503146248	0.771755136818992	0.733868262050829	NA	NA	0.658267107297433	0.789690238591735	NA	NA	p.Gln30Asp	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.179	-3.62	1.441	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30E	30	Q	E	missense	wt-like	0.954826894744127	0.138228513655868	6	0.0564315543933691	0.844223080541511	1.06543070894674	0.793929312391662	1.07177109945777	0.94637694048881	1.09874517791741	NA	NA	0.784569893398019	1.03356894481109	0.695374266785534	0.642386380776449	0.689057140099528	0.70169139347154	0.757041018934985	NA	NA	0.647121727108497	0.704109537863774	NA	NA	p.Gln30Glu	1	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.179	-2.531	0.352	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30F	30	Q	F	missense	wt-like	0.893448153424582	0.078590765066311	6	0.0320845454845686	0.83056359981449	0.956332707034673	0.971043515800815	0.9295899043211	0.845436043865157	0.891799618219031	NA	NA	0.763444368829027	0.95937546951236	0.675799925508514	0.680111488226428	0.65831589230134	0.6714883627906	0.688499848161488	NA	NA	0.642776099504917	0.687423315662897	NA	NA	p.Gln30Phe	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.179	-3.909	1.73	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30G	30	Q	G	missense	wt-like	0.928869806769518	0.076157716075457	6	0.0310912573934376	0.867932062044316	0.989807551494721	0.902108002694276	0.969436462675675	0.883919821676888	0.933405114889907	NA	NA	0.832076968945865	1.0522724697345	0.67496723683798	0.665428308735419	0.666931187193928	0.683003286482033	0.702279749777116	NA	NA	0.656894173619439	0.708315988249809	NA	NA	p.Gln30Gly	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.179	-3.982	1.803	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30H	30	Q	H	missense	possibly_wt-like	0.880123102028641	0.213402339872331	6	0.0871211404338674	0.709368804486204	1.05087739957108	0.736825101426547	0.644242763117923	1.12052578824851	0.961282057786962	NA	NA	0.702184174520266	1.11567872707163	0.670867977653031	0.630223254087345	0.596620481963852	0.753799341467557	0.711512701218717	NA	NA	0.630174566675783	0.72257614919514	NA	NA	p.Gln30His	1	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.179	-2.141	-0.038	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30I	30	Q	I	missense	wt-like	1.01765712278728	0.128549025176118	6	0.0524799197689463	0.914798370128589	1.12051587544596	1.06256427015123	1.00639513360115	0.876460603202224	0.892770057421678	NA	NA	1.2285698621535	1.03918281019387	0.694213278851355	0.699605296319258	0.674922086835189	0.680771376404137	0.688821261383452	NA	NA	0.738454773722851	0.705372104481736	NA	NA	p.Gln30Ile	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.179	-2.935	0.756	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30K	30	Q	K	missense	low	0.368254519239987	0.211941186038868	6	0.0865246268792515	0.198669366780888	0.537839671699087	0.320263794539113	-0.0284123787802226	0.381056553790611	0.474248529152107	NA	NA	0.546286429803097	0.51608418693522	0.545850759318795	0.541496208151175	0.451184523432634	0.532539052298402	0.550205310486416	NA	NA	0.598105609497168	0.587726451336065	NA	NA	p.Gln30Lys	1	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.179	-2.901	0.722	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30L	30	Q	L	missense	wt-like	0.876104459326867	0.121281405009318	6	0.0495129262601093	0.779060907087865	0.973148011565868	0.694415323468789	0.913389589410034	1.0459020226633	0.917964100179392	NA	NA	0.89860198414528	0.786353736094406	0.662695950184362	0.621190023552523	0.654813193547042	0.731470791227898	0.697165625909312	NA	NA	0.670578706821681	0.648510472211794	NA	NA	p.Gln30Leu	1	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.179	-2.01	-0.169	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30M	30	Q	M	missense	wt-like	1.02453958456146	0.112687068964712	5	0.0503951892780606	0.925766828582381	1.12331234054054	1.04369717417746	0.841629902117052	1.00605379524738	NA	NA	NA	1.11908559618706	1.11223145507834	0.715933304644644	0.69558662808611	0.639297904574591	0.719547603744125	NA	NA	NA	0.715933304644644	0.721800852631187	NA	NA	p.Gln30Met	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.179	-4.126	1.947	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30N	30	Q	N	missense	possibly_low	0.694270391357981	0.262810209178073	6	0.107291818613399	0.483982291039915	0.904558491676047	0.883616435929149	0.791710180814063	0.599859859303659	1.05302761948208	NA	NA	0.491181581140213	0.346226671478727	0.613256478649337	0.661489627761757	0.628504673295894	0.598008284002781	0.741899186538917	NA	NA	0.586770262502187	0.549525245179001	NA	NA	p.Gln30Asn	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.179	-2.911	0.732	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30P	30	Q	P	missense	low	0.476858989782216	0.265970416136843	6	0.108581967701828	0.264042243716141	0.689675735848291	0.598959075540803	0.915574463318181	0.245077906868995	0.555164554082033	NA	NA	0.315048421600546	0.231329517282737	0.563771894551996	0.600857960168899	0.655285589000981	0.491852201058724	0.577005011292358	NA	NA	0.550538777811635	0.523684705462492	NA	NA	p.Gln30Pro	1	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.179	-4.434	2.255	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30Q	30	Q	Q	synonymous	possibly_wt-like	0.766196166100478	0.36146031637992	6	0.14756555623263	0.476972990525904	1.05541934167505	0.917266711020371	0.941480280563661	1.15278219076736	0.920816132671162	NA	NA	0.174247984575454	0.490583697004862	0.664771913275453	0.668657094961466	0.660886731589439	0.763450941042363	0.698110230115147	NA	NA	0.521575413435327	0.581991353478795	NA	NA	p.Gln30=	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30R	30	Q	R	missense	possibly_wt-like	0.795044291800784	0.198259114781149	6	0.0809389446782827	0.63640687528467	0.953681708316898	1.0333515047691	1.00298127505039	0.719832912561962	0.719430251964961	NA	NA	0.503295143645841	0.791374662812442	0.641772853767697	0.693383013228806	0.674183970436913	0.633906021487287	0.631410446553841	NA	NA	0.589262083778872	0.649639686048107	NA	NA	p.Gln30Arg	1	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.179	-2.804	0.625	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30S	30	Q	S	missense	wt-like	0.929237325051425	0.0515785714310073	6	0.021056863611277	0.887966630745951	0.9705080193569	0.884950946221332	0.957793589499905	0.944518643656509	0.850637200816976	NA	NA	0.946522883782891	0.991000686330939	0.677651487581666	0.661773876812351	0.66441386098187	0.701135363179382	0.674866696115528	NA	NA	0.680436279047804	0.694535873645401	NA	NA	p.Gln30Ser	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.179	-3.033	0.854	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30T	30	Q	T	missense	wt-like	1.0046044173805	0.133892190369678	6	0.054661257824883	0.897470320694069	1.11173851406693	1.13348809279031	1.02997414417682	0.925457177191317	0.830109708478598	NA	NA	1.17825279058335	0.930344591062583	0.688163057323471	0.714711983294789	0.680020146436152	0.695431886434784	0.668067911159875	NA	NA	0.728104296771027	0.680894228212159	NA	NA	p.Gln30Thr	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.179	-3.307	1.128	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30V	30	Q	V	missense	wt-like	0.981588118101956	0.0509545325132987	6	0.0208021007899395	0.940816749750903	1.02235948645301	1.02999859303184	0.997095802507462	0.89284271549549	0.95611185487145	NA	NA	0.989307836122528	1.02417190658296	0.690953104003065	0.692668847153337	0.672911462003729	0.685673150182281	0.709800309991371	NA	NA	0.689237360852792	0.701996130084002	NA	NA	p.Gln30Val	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.179	-3.248	1.069	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30W	30	Q	W	missense	possibly_low	0.603185342439039	0.313695238760655	6	0.128065544950691	0.35218148667519	0.854189198202888	0.98532657379855	1.02104537235355	0.424250958727912	0.403076697865406	NA	NA	0.319491853951954	0.465920597936858	0.56394870022885	0.683153762009711	0.678089640880274	0.545463466299105	0.526632924349722	NA	NA	0.551452814394152	0.576444586063548	NA	NA	p.Gln30Trp	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.179	-5.733	3.554	0.008262544	NA	NA	NA	NA	NA	NA	NA
Q30X	30	Q	X	nonsense	possibly_low	0.645785726460005	0.170791390552495	6	0.069725293219002	0.509126662939266	0.782444789980744	0.449341771999619	0.691225649949438	0.779005741322095	0.872587535360119	NA	NA	0.457126281012005	0.625427379116755	0.609548315927609	0.56898965856562	0.606778735064577	0.651611419619262	0.682136731919387	NA	NA	0.579764914454993	0.612317896790642	NA	NA	p.Gln30Ter	1	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q30Y	30	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln30Tyr	0	13.2	4.6	12	0.907	108.3	55.2	-61.5	-39.4	30.3738317757009	-5.3	1	0	15.47	0	0	0	0	8	9.31886060188451	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.179	-3.495	1.316	0.008262544	NA	NA	NA	NA	NA	NA	NA
D31A	31	D	A	missense	wt-like	1.01008059472877	0.215752256690495	6	0.0880804899576153	0.837446006671204	1.18271518278634	0.804236281140968	0.714198179900532	1.14744371662047	1.08128177668832	NA	NA	1.02265330478546	1.29067030923688	0.723676882893045	0.644581752440984	0.611745666416498	0.761853589484758	0.751257072820493	NA	NA	0.696096692965597	0.761932014539572	NA	NA	p.Asp31Ala	1	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.229	-2.472	0.243	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31C	31	D	C	missense	wt-like	1.2293614675567	0.236698007775066	6	0.0966315570303729	1.03996709600714	1.41875583910626	0.904011191848355	1.09684195195713	1.35916667569939	1.36518275133259	NA	NA	1.55235307365551	1.09861316084722	0.76189835074019	0.665833685684039	0.69447775348271	0.82520427530997	0.845286175035667	NA	NA	0.805058623340112	0.718738078140269	NA	NA	p.Asp31Cys	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.229	-5.569	3.34	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31E	31	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp31Glu	1	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.229	-2.009	-0.22	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31F	31	D	F	missense	possibly_wt-like	0.776150966961314	0.38664025351364	6	0.157845222521458	0.466780015687545	1.08552191823508	1.27062868852433	1.03508134705228	0.378786964318011	0.738286603126537	NA	NA	0.953178070639041	0.280944128107681	0.659390063443772	0.743922761483303	0.681124383807339	0.531859957077664	0.637655743080205	NA	NA	0.681805284755313	0.534843104732801	NA	NA	p.Asp31Phe	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.229	-4.807	2.578	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31G	31	D	G	missense	wt-like	0.909857843878926	0.0682740965185359	6	0.0278727831866571	0.855228192684185	0.964487495073667	0.886333861918737	1.01970160813175	0.94862179133838	0.87370834461423	NA	NA	0.821098221319107	0.909683235951348	0.677023281082293	0.662068436154711	0.677799103240012	0.702363086525114	0.682507948284708	NA	NA	0.654635789521862	0.676247458924574	NA	NA	p.Asp31Gly	1	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.229	-2.893	0.664	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31H	31	D	H	missense	possibly_wt-like	0.870834061543648	0.35634771031852	4	0.17817385515926	0.521619722444842	1.22004840064245	1.05742455120832	1.12796039463971	0.950288444898745	0.347662855427821	NA	NA	NA	NA	0.699858234773988	0.698510542507017	0.701205927040959	0.702861774275094	0.508279645143026	NA	NA	NA	NA	NA	NA	p.Asp31His	1	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.229	-3.957	1.728	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31I	31	D	I	missense	wt-like	1.22013355358199	0.209616807406997	6	0.0855757032763993	1.05240825720856	1.38785884995542	0.938267798213433	1.02739897236297	1.27166909797592	1.28554960557166	NA	NA	1.27205318773665	1.52586265963129	0.773211600890631	0.673130300699204	0.679463363981366	0.799023687333395	0.818911368778477	NA	NA	0.747399514447867	0.814827121593476	NA	NA	p.Asp31Ile	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.229	-3.919	1.69	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31K	31	D	K	missense	wt-like	0.985979245574942	0.0956717198486393	6	0.0390578160739446	0.909427332755221	1.06253115839466	1.03486889697399	1.08440922035895	0.828574962810366	0.928186561946381	NA	NA	1.06033426616752	0.979501565192447	0.692827960107754	0.693706215901833	0.691789650583443	0.666443274373064	0.700551344833255	NA	NA	0.70384785793083	0.691949704313676	NA	NA	p.Asp31Lys	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.229	-2.296	0.067	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31L	31	D	L	missense	possibly_wt-like	0.739481729452504	0.136303649169921	6	0.0556457317576064	0.630418099314219	0.848545359590789	0.896667071739867	0.912960983878674	0.707793339134513	0.709540274558513	NA	NA	0.604395680216939	0.605533027186519	0.629219224113174	0.664269397135264	0.654720523986665	0.630303600488686	0.628134847737663	NA	NA	0.610058977177911	0.60784362765156	NA	NA	p.Asp31Leu	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.229	-3.477	1.248	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31M	31	D	M	missense	possibly_wt-like	0.782269512623941	0.241399172270074	6	0.0985507993986493	0.589113495154956	0.975425530092925	0.94020125556048	1.17255871286099	0.667283246038053	0.753227815546426	NA	NA	0.484390815232007	0.675955230505689	0.633143007853391	0.673542124735692	0.710848608342835	0.618182372863357	0.642604330493858	NA	NA	0.585373367495686	0.623681685212925	NA	NA	p.Asp31Met	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.229	-4.027	1.798	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31N	31	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp31Asn	1	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.229	-2.723	0.494	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31P	31	D	P	missense	low	0.316604714676451	0.371701108862469	6	0.151746342256625	0.0191873490677776	0.614022080285125	0.697270559201031	0.795678385933397	0.235870453337556	0.298120642252253	NA	NA	-0.164488876714704	0.0371771240491742	0.490484132554544	0.621798185251137	0.629362645946709	0.48909719282316	0.491871072285929	NA	NA	0.451895522175578	0.480019545402486	NA	NA	p.Asp31Pro	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.229	-4.341	2.112	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31Q	31	D	Q	missense	possibly_low	0.386546537683478	0.457110197041732	6	0.186614456495887	0.0207889239570231	0.752304151409932	0.768498251201931	1.13596009395674	0.16086724931727	0.136502337834461	NA	NA	0.12526343864481	-0.0078121448543483	0.490700218066337	0.636969596026931	0.702935556186216	0.466655108911031	0.43834246399219	NA	NA	0.511499043769341	0.469901392363333	NA	NA	p.Asp31Gln	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.229	-2.245	0.016	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31R	31	D	R	missense	wt-like	0.939772974887477	0.193619744419714	6	0.0790449296593984	0.784847759594554	1.0946981901804	1.05702572809573	1.13241637229021	1.04584565974247	0.966625795704168	NA	NA	0.833612618227542	0.60311167526474	0.700297477764263	0.698425593674647	0.702169361853878	0.731453926596376	0.713282567910642	NA	NA	0.657210064469206	0.607299062027283	NA	NA	p.Asp31Arg	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.229	-2.986	0.757	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31S	31	D	S	missense	wt-like	1.07301357652095	0.126185639574119	6	0.0515150716372231	0.972045891450991	1.17398126159091	1.27390323892037	1.0770859105579	1.13400406900516	1.07064106458599	NA	NA	0.921498392338814	0.960948783717456	0.717413250750917	0.744620236689487	0.690206264812346	0.757832245283906	0.747732827765802	NA	NA	0.675288614173033	0.687777156351884	NA	NA	p.Asp31Ser	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.229	-2.52	0.291	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31T	31	D	T	missense	wt-like	1.18194636768741	0.210596767753975	6	0.0859757704127756	1.01343695413529	1.35045578123954	0.988031338406082	0.85758260766856	1.31605047967987	1.23723880767469	NA	NA	1.30270009822544	1.39007487446983	0.768995993780847	0.683729873543863	0.642747067271099	0.81230326259083	0.802910645430333	NA	NA	0.75370373945064	0.784288248111055	NA	NA	p.Asp31Thr	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.229	-3.103	0.874	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31V	31	D	V	missense	wt-like	0.945054563478916	0.164668632102853	6	0.0672256875490124	0.813294637046909	1.07681448991092	1.16699905143824	1.11968300692249	0.755276545789744	0.857066742527506	NA	NA	0.93569713442443	0.835604899771094	0.677602776349498	0.721849776263455	0.699416258395311	0.644511288308068	0.676996185228602	NA	NA	0.678209367470394	0.659587131681538	NA	NA	p.Asp31Val	1	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.229	-3.531	1.302	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31W	31	D	W	missense	possibly_low	0.663562505171817	0.162937918486251	6	0.0665191266737522	0.533187412608205	0.793937597735429	0.78876599963884	0.637178059804962	0.758302527389609	0.812129466157642	NA	NA	0.376743608558641	0.608255369481208	0.62487124398354	0.641286601511722	0.595093009959164	0.645416707401395	0.662112785274276	NA	NA	0.563229790836071	0.608455886455358	NA	NA	p.Asp31Trp	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.229	-5.916	3.687	0.008497346	NA	NA	NA	NA	NA	NA	NA
D31X	31	D	X	nonsense	low	0.301315884783996	0.397100119333415	6	0.162115444860863	-0.0164245484809841	0.619056318048976	0.647183736392281	0.839101356548373	0.210046923363559	-0.0234794446320662	NA	NA	-0.21217753964498	0.347220276676808	0.515559556840868	0.611129753606933	0.638751203262782	0.481370405225832	0.385355878106178	NA	NA	0.442085722218619	0.549748708455905	NA	NA	p.Asp31Ter	0	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D31Y	31	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp31Tyr	1	13.1	0.8	12.3	0.866	100.1	59.5	-60.6	-39.4	47.0588235294118	-6.2	1	0	17.79	0	0	0	0	9	12.1452414628151	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.229	-4.749	2.52	0.008497346	NA	NA	NA	NA	NA	NA	NA
K32A	32	K	A	missense	wt-like	1.08150670943074	0.101552784522257	6	0.0414587506730566	1.00024905126752	1.16276436759396	0.913189498167311	1.01172910583068	1.16941449397261	1.08833689014776	NA	NA	1.14063086138491	1.16573940708117	0.727100072554781	0.667788653639328	0.676075354409701	0.768427575694975	0.753593753719347	NA	NA	0.72036527502552	0.733834870084042	NA	NA	p.Lys32Ala	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.739	-2.737	0.998	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32C	32	K	C	missense	possibly_low	0.717569911536313	0.241684778645729	6	0.0986673977132562	0.524185365570042	0.910954457502585	0.552047988931391	1.05707687641105	0.42767413883927	0.600138398469893	NA	NA	0.723920694052604	0.944561372513668	0.613273200879811	0.590865956428538	0.685880076132336	0.54648773314622	0.591900522715854	NA	NA	0.634645879043767	0.684091603362992	NA	NA	p.Lys32Cys	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.739	-3.222	1.483	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32D	32	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys32Asp	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.739	-4.123	2.384	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32E	32	K	E	missense	wt-like	0.936069584794352	0.126354980923325	6	0.0515842049535414	0.834966400914279	1.03717276867443	0.910366583758078	1.13100059530885	1.0041607798007	0.843089223776265	NA	NA	0.957362865940736	0.770437460181489	0.677516447637102	0.667187376342756	0.701863254207441	0.718981185121662	0.672366776889931	NA	NA	0.682666118384272	0.644930878245828	NA	NA	p.Lys32Glu	1	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.739	-3.796	2.057	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32F	32	K	F	missense	wt-like	1.11166917110814	0.0870618318065613	6	0.035542843999681	1.04200647696064	1.18133186525564	1.1491846035878	1.06839735491636	1.0388620541969	1.1861098872363	NA	NA	1.22274469058312	1.00471643612833	0.723709823914065	0.718055320785667	0.688327696822197	0.729364327042463	0.785976548983231	NA	NA	0.73725650637147	0.697620566037143	NA	NA	p.Lys32Phe	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.739	-3.594	1.855	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32G	32	K	G	missense	wt-like	0.863342674666288	0.055629223113078	6	0.0227105352357469	0.818830843534596	0.90785450579798	0.797643642653545	0.858966567796864	0.943510207139507	0.911561938946322	NA	NA	0.815673556318955	0.852700135142536	0.65847589188786	0.643177528553065	0.643046295739436	0.700833623843974	0.695045205316404	NA	NA	0.653519908404314	0.663431875371406	NA	NA	p.Lys32Gly	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.739	-3.078	1.339	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32H	32	K	H	missense	wt-like	1.00123880663112	0.14199324307633	6	0.0579684987433315	0.887622636856339	1.11485497640591	1.1140031574062	1.16580364541266	0.919514549230821	0.840486998465886	NA	NA	0.865732499916694	1.10189198935449	0.701520923124207	0.71056171602727	0.709388083256356	0.693653762992058	0.671504909789957	NA	NA	0.663817287122365	0.719475491515376	NA	NA	p.Lys32His	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.739	-3.985	2.246	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32I	32	K	I	missense	possibly_low	0.688719931460197	0.139190872164228	6	0.0568244356092201	0.57734608422431	0.800093778696083	0.456170519194485	0.877936763843427	0.666644816503363	0.705695495318302	NA	NA	0.662736696444857	0.763135297456745	0.624460731113498	0.570444173317777	0.647147875395501	0.617991345168252	0.62686144196431	NA	NA	0.622060020262686	0.643288611061531	NA	NA	p.Lys32Ile	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.739	-3.66	1.921	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32L	32	K	L	missense	wt-like	0.957639916033573	0.212300261882332	6	0.0866712189784924	0.787767448339544	1.1275123837276	1.13026586143995	1.0547036817727	0.728342064248204	0.875326075231078	NA	NA	0.727698420871732	1.22950339263777	0.684205355224891	0.714025651980975	0.685366963520076	0.636452087334181	0.683043746929707	NA	NA	0.635422976620226	0.748175484634404	NA	NA	p.Lys32Leu	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.739	-3.049	1.31	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32M	32	K	M	missense	possibly_wt-like	0.927846545400729	0.285652197318231	6	0.116617021222414	0.699281383820454	1.156411706981	1.09183758351169	1.04147066862828	0.993143326664412	0.400515284287077	NA	NA	1.20557603660509	0.834536372707817	0.694173153193083	0.705840476054614	0.682505830331553	0.715684597848995	0.525784574253447	NA	NA	0.733724827127265	0.65934681836647	NA	NA	p.Lys32Met	1	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.739	-3.198	1.459	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32N	32	K	N	missense	possibly_wt-like	0.82186014729717	0.203551775337397	6	0.0830996643023765	0.658987798137143	0.984732496457196	1.09167979172111	1.01258881807269	0.694247711369244	0.560775180024345	NA	NA	0.859944789005274	0.711924593590353	0.647198986863455	0.705806866597327	0.676261234314856	0.626250545436952	0.578863272331728	NA	NA	0.662626725618622	0.631771248108289	NA	NA	p.Lys32Asn	1	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.739	-3.555	1.816	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32P	32	K	P	missense	possibly_low	0.559037725054767	0.433548523934506	6	0.176995443729393	0.21213302991747	0.905942420192063	0.744300993300682	1.07576953608179	0.677986614271804	0.800540957129883	NA	NA	0.0562543568170144	-0.000626107272573899	0.626600295540544	0.631815609860104	0.689921649157467	0.621384981220985	0.658274626207518	NA	NA	0.497303525456449	0.471517542831424	NA	NA	p.Lys32Pro	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.739	-4.331	2.592	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32Q	32	K	Q	missense	possibly_wt-like	0.835898888964709	0.159873712644658	6	0.0652681698772926	0.707975626668373	0.963822151261044	0.927616583857382	1.02549669943034	0.705502642047432	0.601502253411504	NA	NA	0.940920096712938	0.814355058328654	0.662834808046299	0.670861605143904	0.679052070184423	0.629618189553019	0.592352236754075	NA	NA	0.679283757316633	0.654808010948694	NA	NA	p.Lys32Gln	1	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.739	-3.618	1.879	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32R	32	K	R	missense	wt-like	0.986720716506204	0.0640594978492624	6	0.0261521804849349	0.93546338463854	1.03797804837387	0.935353140253134	1.01528186303388	0.931604605697441	0.938719639785042	NA	NA	1.09323399820884	1.00613105205888	0.697605002261557	0.672509482139112	0.676843502331411	0.697271289273374	0.704039941003003	NA	NA	0.710615499758716	0.697938715249739	NA	NA	p.Lys32Arg	1	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.739	-1.538	-0.201	0.006357969	NA	NA	NA	NA	4.06e-06	NA	NA
K32S	32	K	S	missense	wt-like	0.868743534313813	0.0567892367438619	6	0.0231841088174292	0.823303516017994	0.914183552609631	0.90923819176659	0.911049054592164	0.776245798616467	0.883375112267799	NA	NA	0.91051127458673	0.822041774053126	0.661741897453693	0.666947030236655	0.654307142372362	0.650785603354458	0.685709619166348	NA	NA	0.673028508298203	0.656536764670731	NA	NA	p.Lys32Ser	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.739	-2.858	1.119	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32T	32	K	T	missense	wt-like	1.01396370878982	0.17297055323147	6	0.0706149326573361	0.875560984010721	1.15236643356892	1.28244453153101	1.16311344489059	0.895109468684617	0.832821244278112	NA	NA	0.981686193850606	0.928607369503993	0.687010473553256	0.746439521508523	0.708806430241018	0.686351396744451	0.668965982317158	NA	NA	0.687669550362061	0.68050352451723	NA	NA	p.Lys32Thr	1	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.739	-3.283	1.544	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32V	32	K	V	missense	wt-like	1.06176288612144	0.185062880026376	6	0.0755516043990871	0.913684462525011	1.20984130971787	0.810269306246528	0.886121757132375	1.13492926793256	1.05840299582176	NA	NA	1.30341979263645	1.17743419695897	0.740072288801593	0.645866779366972	0.648917567278314	0.758109078683697	0.743679531998886	NA	NA	0.753851784243014	0.736465045604301	NA	NA	p.Lys32Val	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.739	-3.469	1.73	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32W	32	K	W	missense	wt-like	0.971234813788032	0.303688552857126	6	0.123980332537366	0.728237827223495	1.21423180035257	0.909753681646099	0.845672891738422	1.17147410202265	0.688603998782112	NA	NA	0.728252148649188	1.48365205988972	0.653614437730895	0.667056828946863	0.640172046514926	0.769043841323741	0.621200672124314	NA	NA	0.635536881233895	0.80533389535378	NA	NA	p.Lys32Trp	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.739	-5.677	3.938	0.006357969	NA	NA	NA	NA	NA	NA	NA
K32X	32	K	X	nonsense	low	0.607474947453237	0.107377350097455	6	0.0438366196118255	0.521556751810077	0.693393143096397	0.622584837091828	0.768394722658479	0.692849314227621	0.494365100583053	NA	NA	0.518364714088852	0.548290996069589	0.600430014302865	0.605890218316152	0.623463596830049	0.625832124032097	0.556867996846226	NA	NA	0.592361970888296	0.594969810289578	NA	NA	p.Lys32Ter	1	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K32Y	32	K	Y	missense	wt-like	1.03728499308908	0.146087657382941	6	0.059640036384456	0.920392669738892	1.15417731643928	1.04429310351502	1.13632187659427	1.12584169144623	0.90876911778848	NA	NA	1.19173650272597	0.816747666464535	0.699363669076201	0.695713560301931	0.703013777850471	0.755389939458541	0.694120212133663	NA	NA	0.730877964780753	0.655346112053059	NA	NA	p.Lys32Tyr	0	15.9	0.9	14.9	0.931	108.1	45.8	-53.5	-45.5	25.6521739130435	-4.8	1	0	16.32	0	0	0	0	8	10.6181362518481	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.739	-3.583	1.844	0.006357969	NA	NA	NA	NA	NA	NA	NA
W33A	33	W	A	missense	possibly_wt-like	0.834219992187733	0.165210086511619	6	0.0674467353857553	0.702026819956849	0.966413164418616	0.740067238310569	0.835369761975081	0.914511051739076	0.76763808366167	NA	NA	0.635558033911715	1.11217578352829	0.64266072784727	0.630913825255343	0.637944388596822	0.69215664147531	0.647377067097718	NA	NA	0.616469231463729	0.721788332017335	NA	NA	p.Trp33Ala	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	148	-0.9	1.8	-2.7	264	121	143	5.4	8.1	-2.7	204	89	115	5.89	6	0.11	-0.597	-3.76	3.163	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33C	33	W	C	missense	wt-like	0.864346566900294	0.0996500293769236	6	0.0406819541378028	0.78461140196949	0.944081731831097	0.986933929346314	0.898541405526299	0.781918293163012	0.781870488072891	NA	NA	0.768848653119079	0.967966632174166	0.652286896690478	0.683496126764104	0.651602841434837	0.652482898826931	0.652090894554025	NA	NA	0.643887788206977	0.689355480837282	NA	NA	p.Trp33Cys	1	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	215	-0.9	2.5	-3.4	264	148	116	5.4	5.5	-0.0999999999999996	204	121	83	5.89	5.07	-0.82	-0.597	-5.141	4.544	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33D	33	W	D	missense	wt-like	0.922110740652588	0.0695113044366467	6	0.0283778712041742	0.86649113513449	0.977730346170686	0.941644958752678	0.953654527462102	0.805791028358866	0.871770071851811	NA	NA	0.97551958840694	0.984284269083132	0.677857808289728	0.673849631739666	0.663518947054371	0.659625979358964	0.68186598483979	NA	NA	0.686401048330366	0.693025341484191	NA	NA	p.Trp33Asp	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	181	-0.9	-3.5	2.6	264	187	77	5.4	13	-7.6	204	133	71	5.89	5.05	-0.84	-0.597	-4.376	3.779	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33E	33	W	E	missense	low	0.585763497521923	0.0719492380004443	6	0.029373153413859	0.52819317471839	0.643333820325457	0.588661648245414	0.708285420851711	0.57181674890109	0.601003250788575	NA	NA	0.487704081946092	0.557109834398657	0.594570072605419	0.598664620822311	0.61046725831959	0.589617364640972	0.592186965152962	NA	NA	0.586054923271673	0.596953180057876	NA	NA	p.Trp33Glu	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	152	-0.9	-3.5	2.6	264	214	50	5.4	12.3	-6.9	204	147	57	5.89	3.22	-2.67	-0.597	-4.15	3.553	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33F	33	W	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp33Phe	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	40	-0.9	2.8	-3.7	264	228	36	5.4	5.2	0.2	204	165	39	5.89	3.32	-2.57	-0.597	-3.687	3.09	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33G	33	W	G	missense	possibly_wt-like	0.750751076397375	0.151065709835378	6	0.061672317788003	0.62987555468978	0.87162659810497	0.806128628115331	1.02642262122668	0.60766616761161	0.648133731843937	NA	NA	0.722168737598858	0.693986571987835	0.631011226630537	0.644984820018662	0.679252265374479	0.600344048566167	0.607796762992359	NA	NA	0.634285492711072	0.627736960550002	NA	NA	p.Trp33Gly	1	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	184	-0.9	-9.4	8.5	264	97	167	5.4	9	-3.6	204	75	129	5.89	3.29	-2.6	-0.597	-2.959	2.362	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33H	33	W	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp33His	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	115	-0.9	-3.2	2.3	264	216	48	5.4	10.4	-5	204	155	49	5.89	7.59	1.7	-0.597	-4.951	4.354	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33I	33	W	I	missense	possibly_low	0.694055372723987	0.125493436613185	6	0.051232480961768	0.593641555200288	0.794469190247686	0.688099954958604	0.835167115354959	0.660769289348529	0.803410840291553	NA	NA	0.480229093568234	0.696655942822043	0.624091081911378	0.619844857828674	0.637900574012491	0.61623329929329	0.65922514262435	NA	NA	0.584517280231133	0.628337305994083	NA	NA	p.Trp33Ile	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	61	-0.9	4.5	-5.4	264	191	73	5.4	5.2	0.2	204	131	73	5.89	6.02	0.13	-0.597	-4.289	3.692	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33K	33	W	K	missense	possibly_low	0.627606025677925	0.217538773285889	6	0.0888098323035701	0.453541952889886	0.801670098465965	0.788376544644806	0.913013020569869	0.579381377592288	0.373825400390366	NA	NA	0.717056645828538	0.393983165041686	0.612557362265073	0.641203648077078	0.65473177493175	0.591880815037118	0.516944781349673	NA	NA	0.633233909493028	0.560265751132088	NA	NA	p.Trp33Lys	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	110	-0.9	-3.9	3	264	230	34	5.4	11.3	-5.9	204	146	58	5.89	9.74	3.85	-0.597	-4.167	3.57	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33L	33	W	L	missense	possibly_wt-like	0.732479987951265	0.105920244090806	6	0.0432417585755865	0.647727698514939	0.81723227738759	0.616639237387402	0.78150935344103	0.7202819239727	0.628054590736996	NA	NA	0.745473511889245	0.902921310280216	0.630169753398251	0.60462381289306	0.626299134358627	0.634040372437875	0.601146473700809	NA	NA	0.639079403040767	0.674726691851728	NA	NA	p.Trp33Leu	1	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	61	-0.9	3.8	-4.7	264	191	73	5.4	4.9	0.5	204	131	73	5.89	9.71	3.82	-0.597	-3.644	3.047	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33M	33	W	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp33Met	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	67	-0.9	1.9	-2.8	264	203	61	5.4	5.7	-0.3	204	149	55	5.89	5.74	-0.15	-0.597	-4.766	4.169	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33N	33	W	N	missense	possibly_low	0.349023606729605	0.540344549455385	6	0.220594738576627	-0.083334136059612	0.781381349518823	1.02046054456383	1.02153486373791	-0.193360403338797	0.114333320103085	NA	NA	0.218605047276746	-0.0874317319651411	0.491347357959584	0.690637254562834	0.678195474678668	0.360664880776862	0.430999999469532	NA	NA	0.530699886319252	0.451994829599916	NA	NA	p.Trp33Asn	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	174	-0.9	-3.5	2.6	264	187	77	5.4	11.6	-6.2	204	132	72	5.89	5.47	-0.42	-0.597	-4.561	3.964	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33P	33	W	P	missense	low	0.57004872121605	0.18802700166987	6	0.0767617019927702	0.419598549918224	0.720498892513876	0.553299146791265	0.892553247260658	0.612371510688383	0.516374276915333	NA	NA	0.312230089129776	0.533464056510887	0.59138383059627	0.591132451513585	0.650308131139837	0.60175195780876	0.564157521278514	NA	NA	0.549959032521001	0.591635209678954	NA	NA	p.Trp33Pro	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	147	-0.9	-1.6	0.7	264	154	110	5.4	8	-2.6	204	115	89	5.89	6.3	0.41	-0.597	-4.578	3.981	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33Q	33	W	Q	missense	wt-like	0.824521503639687	0.0956394039780833	6	0.0390446231750353	0.74799544842668	0.901047558852694	0.767731442263208	0.871337086025879	0.693241360401211	0.791813555370063	NA	NA	0.970162375851228	0.852843201926532	0.650552512161834	0.63680626666627	0.645720947376065	0.625949430129084	0.655384076947603	NA	NA	0.685299042522921	0.66346405130248	NA	NA	p.Trp33Gln	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	130	-0.9	-3.5	2.6	264	214	50	5.4	10.5	-5.1	204	146	58	5.89	6.24	0.35	-0.597	-4.395	3.798	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33R	33	W	R	missense	possibly_low	0.61386269901403	0.184742858674052	6	0.0754209562290887	0.466040341125445	0.761685056902616	0.801754737060815	0.886471932073285	0.541124818776543	0.522357295702394	NA	NA	0.424008583351575	0.507458827119571	0.58311023692475	0.644053186604571	0.648993279221943	0.580433878678239	0.566139120270165	NA	NA	0.572952435993208	0.585786595171262	NA	NA	p.Trp33Arg	1	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	101	-0.9	-4.5	3.6	264	265	-1	5.4	10.5	-5.1	204	174	30	5.89	6.34	0.45	-0.597	-4.419	3.822	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33S	33	W	S	missense	possibly_wt-like	0.723419358641176	0.140884146039425	6	0.0575157117740564	0.610690635018839	0.836148082263513	0.662696189784825	0.795041876870699	0.632553631582505	0.554604826387307	NA	NA	0.741217770184363	0.954401857037355	0.62182945614645	0.614433887096976	0.629225025195924	0.607790751171616	0.576819627312306	NA	NA	0.638203975376661	0.686304742869739	NA	NA	p.Trp33Ser	1	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	177	-0.9	-0.8	-0.1	264	143	121	5.4	9.2	-3.8	204	105	99	5.89	5.68	-0.21	-0.597	-4.068	3.471	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33T	33	W	T	missense	possibly_low	0.63008550024894	0.123903813616359	6	0.0505835200908318	0.530943622659652	0.729227377838229	0.658348322397057	0.78749729117975	0.583232676996191	0.663211067093597	NA	NA	0.415449319324405	0.672774324502643	0.61314911575313	0.613507796691889	0.627593796973112	0.593033181599615	0.612790434814371	NA	NA	0.571191751949537	0.62296629475368	NA	NA	p.Trp33Thr	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	128	-0.9	-0.7	-0.2	264	163	101	5.4	8.6	-3.2	204	119	85	5.89	5.6	-0.29	-0.597	-3.917	3.32	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33V	33	W	V	missense	possibly_wt-like	0.798375222710656	0.14226101653404	6	0.0580778167996733	0.684544793482581	0.912205651938731	0.79461258124424	1.02894504432637	0.88480071262525	0.710115033639393	NA	NA	0.746917045971626	0.62486091845706	0.640954130764068	0.642531916201528	0.679797642936433	0.683266862269745	0.628325210171018	NA	NA	0.639376345326608	0.612190498951443	NA	NA	p.Trp33Val	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	88	-0.9	4.2	-5.1	264	165	99	5.4	5.9	-0.5	204	117	87	5.89	5.61	-0.28	-0.597	-4.024	3.427	0.001488209	NA	NA	NA	NA	NA	NA	NA
W33X	33	W	X	nonsense	possibly_wt-like	0.724238009608058	0.0955478440049577	6	0.0390072439725318	0.647785216285729	0.800690802930388	0.712398655327797	0.893040688991527	0.724063594148184	0.597857934032343	NA	NA	0.692031606290068	0.726035578858431	0.631515480706864	0.625020451116384	0.650413521779024	0.635171904890585	0.591145224062987	NA	NA	0.628086131872458	0.63494482954127	NA	NA	p.Trp33Ter	1	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	NA	-0.9	NA	NA	264	NA	NA	5.4	NA	NA	204	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
W33Y	33	W	Y	missense	possibly_low	0.572513432067861	0.399076228719607	6	0.162922188139545	0.253191811031894	0.891835053103828	0.989073627995097	1.16118010075854	0.309276572123502	0.321265031839532	NA	NA	0.218917693325045	0.435367566365449	0.550168681662479	0.683951879944156	0.708388418485065	0.511061404872185	0.499536583744412	NA	NA	0.530764199197884	0.569573164127074	NA	NA	p.Trp33Tyr	0	13.7	3.1	17	0.946	112.5	49	-63.3	-49.2	2.27272727272727	-3	1	0	16.07	1	1213	0	0	7	10.2927988599749	37	-0.9	-1.3	0.4	264	255	9	5.4	6.2	-0.8	204	181	23	5.89	5.66	-0.23	-0.597	-3.561	2.964	0.001488209	NA	NA	NA	NA	NA	NA	NA
V34A	34	V	A	missense	wt-like	1.0927915228604	0.038982705813938	6	0.0159146230061959	1.06159943494073	1.12398361078008	1.14631021297954	1.06186167942039	1.0871730829442	1.10380557919713	NA	NA	1.0385941301741	1.11900445244707	0.720383594433601	0.717443079122025	0.686914606857965	0.743819711651564	0.758717043435347	NA	NA	0.69937580163845	0.723324109745177	NA	NA	p.Val34Ala	1	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.876	-2.242	-0.634	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34C	34	V	C	missense	possibly_low	0.710293038356864	0.244376753900029	6	0.099766392008795	0.514754503152121	0.905831573561606	1.00718259514616	0.989697407020305	0.454622532876841	0.637540210610045	NA	NA	0.461839706377546	0.710875778110282	0.617911757846723	0.687809067670675	0.67131184182357	0.554551096947648	0.604288147736042	NA	NA	0.580734489970574	0.631535367957403	NA	NA	p.Val34Cys	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.876	-5.557	2.681	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34D	34	V	D	missense	wt-like	0.927649537308354	0.116663080808905	6	0.0476275033004831	0.834301346165845	1.02099772845086	0.774920691718267	1.01305833999209	1.03752176085672	1.02192013984497	NA	NA	0.799607955129353	0.918868336308725	0.677337976022007	0.638337567956377	0.676362750479895	0.728963291166728	0.731596268818682	NA	NA	0.65021513271604	0.678313201564118	NA	NA	p.Val34Asp	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.876	-2.727	-0.149	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34E	34	V	E	missense	possibly_wt-like	0.772801730842278	0.410798483395304	6	0.16770777857128	0.44410052491535	1.10150293676921	0.724101276237127	0.866991180012664	1.06394317326301	1.31754900528065	NA	NA	0.155184477769801	0.509041272490413	0.636147203160385	0.62751309497415	0.64478131134662	0.736868974157797	0.829509693880499	NA	NA	0.517653953349206	0.586142489472914	NA	NA	p.Val34Glu	1	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.876	-2.13	-0.746	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34F	34	V	F	missense	wt-like	1.17844276917284	0.181174667632955	6	0.0739642483365126	1.0334755062897	1.32341003205598	0.948017268236774	1.09070199523094	1.12637178385024	1.23985226841767	NA	NA	1.17608111108113	1.48963218822029	0.74160306116809	0.675206925820913	0.693150222573938	0.75554855105877	0.803776233749095	NA	NA	0.72765757127741	0.806678835049783	NA	NA	p.Val34Phe	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.876	-4.097	1.221	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34G	34	V	G	missense	wt-like	0.90161870175801	0.141261801161699	6	0.0576698888321096	0.788587796654647	1.01464960686137	1.00526335839745	1.11372205226048	0.742165448940997	0.836593363652992	NA	NA	0.784479628065266	0.927488359230875	0.675233590157713	0.687400272604139	0.698127429839591	0.640588251425803	0.670215322861737	NA	NA	0.647103159071505	0.68025185745369	NA	NA	p.Val34Gly	1	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.876	-3.186	0.31	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34H	34	V	H	missense	wt-like	0.91003360634196	0.17897307805455	6	0.0730654531548257	0.766827949644403	1.05323926303952	1.03112452190499	1.14596076813737	0.694049940914629	1.00467767856171	NA	NA	0.84899911650293	0.735389612030118	0.676641906930118	0.692908668618262	0.705097819647571	0.626191369549791	0.725885498869845	NA	NA	0.660375145241974	0.637048565420318	NA	NA	p.Val34His	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.876	-3.08	0.204	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34I	34	V	I	missense	wt-like	1.26819090464476	0.159413751828376	6	0.0650803916603652	1.14063568089068	1.39574612839883	1.25569621651126	1.05557467355891	1.48592072872942	1.17463993770441	NA	NA	1.4197762763608	1.21753759500373	0.761635631227969	0.740742163313625	0.685555282195441	0.86313098966117	0.782177657280628	NA	NA	0.777786903386528	0.74548435906941	NA	NA	p.Val34Ile	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.876	-3.887	1.011	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34K	34	V	K	missense	possibly_low	0.521468521816241	0.529402990868749	3	0.305650959287865	-0.0775963502280926	1.12053339386058	NA	-0.0898333445052393	0.826900560750132	0.827338349203831	NA	NA	NA	NA	0.665942268155673	NA	0.437904587745346	0.665942268155673	0.66715002623592	NA	NA	NA	NA	NA	NA	p.Val34Lys	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.876	-2.491	-0.385	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34L	34	V	L	missense	possibly_wt-like	0.818234536706238	0.205704071988579	6	0.0839783357307927	0.653640023192271	0.982829050220205	1.0111436554257	1.14248540772326	0.683063067334369	0.651931239970103	NA	NA	0.706512476496865	0.714271373287127	0.631681981342489	0.688652768637538	0.704346405822588	0.622903932139071	0.609054512389682	NA	NA	0.631064920355982	0.632299042328996	NA	NA	p.Val34Leu	1	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.876	-3.346	0.47	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34M	34	V	M	missense	wt-like	1.03174378316523	0.115479839336464	6	0.047144446992153	0.93934236498955	1.12414520134091	1.0830851805392	0.911422243288686	1.01561941516589	1.21239892781887	NA	NA	0.906175419977584	1.06176151220114	0.707213156453469	0.703976224988198	0.654387830160815	0.722409780736251	0.794683581029085	NA	NA	0.672136601003164	0.71045008791874	NA	NA	p.Val34Met	1	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.876	-4.293	1.417	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34N	34	V	N	missense	possibly_low	0.640627412597857	0.17548832947784	6	0.0716428105056873	0.500210084255482	0.781044740940232	0.56632734474932	0.836620772437719	0.683998103188227	0.768292107459747	NA	NA	0.337702316794988	0.650823830957142	0.620606652611312	0.593907441652077	0.638214871782683	0.623183708894841	0.647593682312363	NA	NA	0.555198799008461	0.618029596327782	NA	NA	p.Val34Asn	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.876	-3.081	0.205	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34P	34	V	P	missense	low	0.519039012574099	0.153033040482127	6	0.0624754771613157	0.396589327420966	0.641488697727233	0.624526222538163	0.622103730650345	0.261779272858887	0.522338276092799	NA	NA	0.423165795371285	0.660320777933118	0.582306416403384	0.606303731028036	0.591833762577764	0.496849500332645	0.566132820901814	NA	NA	0.572779070229004	0.620165473732541	NA	NA	p.Val34Pro	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.876	-4.396	1.52	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34Q	34	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val34Gln	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.876	-2.221	-0.655	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34R	34	V	R	missense	wt-like	1.02886945780412	0.100728689225428	6	0.0411223151769469	0.948271201096401	1.10946771451184	0.943444520270336	1.08172659980486	1.15950496065256	1.09724828775818	NA	NA	0.895414113374222	0.995878264964583	0.69342124236608	0.674232936129205	0.691209636446394	0.76546249465339	0.756545243117506	NA	NA	0.669922945627486	0.695632848285766	NA	NA	p.Val34Arg	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.876	-2.465	-0.411	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34S	34	V	S	missense	wt-like	1.09126679508755	0.0549388897623153	6	0.0224287078254479	1.0473073355299	1.1352262546452	1.12862982995881	0.996375209347726	1.11120866489616	1.08041303965414	NA	NA	1.15423155166071	1.07674247500775	0.718491167308097	0.713677179288047	0.672755661281532	0.751011518376206	0.75096934375057	NA	NA	0.723163006030837	0.713819328585358	NA	NA	p.Val34Ser	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.876	-2.914	0.038	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34T	34	V	T	missense	wt-like	1.12365412098509	0.19927196687292	6	0.0813524398132413	0.964206268896678	1.28310197307351	0.797516359096584	0.96328716009915	1.3066125508856	1.26223809195554	NA	NA	1.21555850134632	1.19671206252736	0.7382894684148	0.643150417312009	0.665601635602317	0.809479292698819	0.811190505194449	NA	NA	0.735778270779733	0.740800666049867	NA	NA	p.Val34Thr	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.876	-3.268	0.392	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34V	34	V	V	synonymous	wt-like	1.2194026737973	0.127813098181672	6	0.0521794788315575	1.11713277455537	1.32167257303922	1.1504563388236	1.05889420131798	1.1607169727009	1.20325848075697	NA	NA	1.3956814824637	1.34740856672062	0.769327814428426	0.718326198826475	0.686273003166323	0.76582514684201	0.791656229565596	NA	NA	0.772830482014842	0.774692532467223	NA	NA	p.Val34=	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34W	34	V	W	missense	possibly_wt-like	0.746401874673475	0.173224583347567	6	0.0707186400179593	0.607795887202622	0.885007862144328	0.641703426334679	0.511628008623743	0.791095379167369	1.03019537660047	NA	NA	0.777939187799792	0.7258498695148	0.640330410277755	0.60996245430624	0.567947611225337	0.65522882064279	0.734337059278148	NA	NA	0.645757757319971	0.634903063235539	NA	NA	p.Val34Trp	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.876	-4.52	1.644	0.008317489	NA	NA	NA	NA	NA	NA	NA
V34X	34	V	X	nonsense	low	0.512449280714118	0.251603547601975	6	0.102716718183149	0.311128212464994	0.713770348963241	0.691987456145332	0.919528491393253	0.508258205369367	0.353415643054226	NA	NA	0.258124639095869	0.343381249226659	0.559742500180822	0.620672890799256	0.65614049640797	0.570599694850681	0.510184990682693	NA	NA	0.538829266895367	0.548885305510962	NA	NA	p.Val34Ter	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V34Y	34	V	Y	missense	wt-like	0.803204782445236	0.078705261701452	6	0.0321312885401287	0.740228614129719	0.866180950760753	0.819150878103759	0.897772656047959	0.804334156400236	0.668614044804995	NA	NA	0.77347170343366	0.855885255880807	0.649597585998359	0.64775854324694	0.651436628749779	0.659190061411566	0.61457992195554	NA	NA	0.644838773115975	0.66414821373083	NA	NA	p.Val34Tyr	0	10.6	0.9	16.6	0.885	115.7	45.9	-54.6	-40.2	60	-2.9	1	0	19.13	0	0	0	0	6	13.8008602896898	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.876	-4.042	1.166	0.008317489	NA	NA	NA	NA	NA	NA	NA
N35A	35	N	A	missense	wt-like	1.13906300645176	0.151285994279633	6	0.061762248535786	1.0180112237174	1.26011478918611	0.906218917365493	1.05658352107091	1.26755626000339	1.27620066670394	NA	NA	1.07207772276851	1.25574095079829	0.730169948385185	0.666303928503367	0.685773406901223	0.797793064507312	0.815814964021508	NA	NA	0.706263546544859	0.754076350225512	NA	NA	p.Asn35Ala	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.397	-2.526	0.129	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35C	35	N	C	missense	wt-like	1.14490296793203	0.201846191097573	6	0.0824033624522265	0.983395345320665	1.30641059054339	0.835769225042668	0.987730918911909	1.30263152483844	1.2408572981926	NA	NA	1.36687106591199	1.13555777469456	0.746975504753482	0.651298230701949	0.670886663949842	0.808288109978375	0.804109103502554	NA	NA	0.766904033134065	0.7270469763729	NA	NA	p.Asn35Cys	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.397	-5.562	3.165	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35D	35	N	D	missense	possibly_wt-like	0.935259835687673	0.485350276817332	6	0.198143420786839	0.546905867171904	1.32361380420344	1.31286977916456	1.17663575271748	1.21718644374861	1.22721902218723	NA	NA	0.114348306069062	0.563299710239103	0.73232508708588	0.752920061826999	0.71173011234476	0.782721659788088	0.79959205367504	NA	NA	0.509253745610567	0.59834529227871	NA	NA	p.Asn35Asp	1	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.397	-2.509	0.112	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35E	35	N	E	missense	wt-like	1.17644803136872	0.12898843426375	6	0.0526593077777865	1.07323768467345	1.27965837806399	1.08971257007151	0.972286152548069	1.28153162249365	1.22263390858497	NA	NA	1.32063030794267	1.17189362657147	0.746305518856952	0.705387850805929	0.667547323683926	0.801974702636052	0.798073446294015	NA	NA	0.75739207457485	0.735218963139054	NA	NA	p.Asn35Glu	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.397	-2.21	-0.187	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35F	35	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn35Phe	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.397	-4.792	2.395	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35G	35	N	G	missense	wt-like	0.968478391597722	0.0707103129370609	6	0.0288673643747199	0.911899397094677	1.02505738610077	0.837051927587195	0.94887897226677	0.988082396358856	0.989704409356796	NA	NA	1.03834562114899	1.00880702286773	0.698932613554406	0.651571444766023	0.662486415814973	0.714170291572693	0.72092629412485	NA	NA	0.699324682070945	0.698540545037867	NA	NA	p.Asn35Gly	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.397	-3.534	1.137	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35H	35	N	H	missense	wt-like	0.98047199103953	0.139597678146262	6	0.0569905134559361	0.86877263720545	1.09217134487361	0.806191838877681	1.04888980752482	1.07692287068373	1.13348156264161	NA	NA	0.810290823383552	1.00705504312578	0.69112822884333	0.644998283833284	0.684109935480961	0.740752694359818	0.768545844073083	NA	NA	0.652412652925266	0.6981465222057	NA	NA	p.Asn35His	1	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.397	-3.485	1.088	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35I	35	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn35Ile	1	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.397	-3.748	1.351	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35K	35	N	K	missense	possibly_wt-like	0.738215022853283	0.138443631716383	6	0.056519375973822	0.627439081515914	0.848990964190653	0.48937606282145	0.741963914554725	0.855625409348621	0.770037990684015	NA	NA	0.700978367535242	0.871308392175648	0.639049225828704	0.577516913262683	0.617748945039123	0.674537173813785	0.648171925597213	NA	NA	0.629926526060195	0.667616899868174	NA	NA	p.Asn35Lys	1	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.397	-2.351	-0.046	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35L	35	N	L	missense	wt-like	1.0896112155939	0.141077156326714	6	0.057594507893884	0.976728054414578	1.20249437677322	0.982018792259181	0.869117081277433	1.20075232738283	1.23118969465177	NA	NA	1.08211104567717	1.172478352315	0.721838960401517	0.682449208610877	0.645240956220979	0.777804325611236	0.800907155771815	NA	NA	0.708327451980443	0.735350468822591	NA	NA	p.Asn35Leu	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.397	-3.142	0.745	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35M	35	N	M	missense	wt-like	1.04815422270246	0.106200644329101	6	0.0433562314935163	0.963177570469789	1.13313087493514	0.931768501398195	1.1205681121752	0.929664779140704	1.0099309788504	NA	NA	1.11714704828735	1.17984591636293	0.707571082036458	0.671745958472636	0.699607628568244	0.696690864064479	0.727625412268983	NA	NA	0.715534535504672	0.737007444861088	NA	NA	p.Asn35Met	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.397	-3.704	1.307	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35P	35	N	P	missense	wt-like	0.832787175519841	0.119169136706839	6	0.0486505963366214	0.737433758873667	0.928140592166016	0.685239760521807	0.756335373393293	0.807430911557827	0.895048562057268	NA	NA	0.8229664872262	1.02970195836265	0.657568379157246	0.61923563993209	0.620856223585721	0.660116657015178	0.689575910942321	NA	NA	0.655020101299313	0.703239846898812	NA	NA	p.Asn35Pro	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.397	-4.392	1.995	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35Q	35	N	Q	missense	wt-like	1.07254626756609	0.152299907981851	6	0.0621761770713943	0.950683199809777	1.19440933532241	0.901649176321705	0.958632252038402	1.15556843596737	1.05198493319378	NA	NA	1.3282184978795	1.03922430999581	0.723467641325454	0.665330579282484	0.664595189693379	0.764284627408102	0.741553844802407	NA	NA	0.758953003750501	0.705381437848502	NA	NA	p.Asn35Gln	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.397	-2.608	0.211	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35R	35	N	R	missense	possibly_low	0.711247447329526	0.194231368254775	6	0.0792946240444691	0.555832840034723	0.866662054624329	0.951658151406398	0.96442609186865	0.619538804430912	0.608851132626271	NA	NA	0.522830591464935	0.600179912179988	0.605268111902745	0.675982429457228	0.665847886055605	0.603896519627069	0.594786214008708	NA	NA	0.593280624526284	0.606639704178422	NA	NA	p.Asn35Arg	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.397	-2.476	0.079	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35S	35	N	S	missense	wt-like	1.24908453518848	0.111725376226434	6	0.0456116938458737	1.1596872579767	1.33848181240026	1.3398979721174	1.07376717381087	1.26354049685966	1.33088109103462	NA	NA	1.3339319969092	1.15248848039915	0.759402666585473	0.758677033677355	0.689488714867578	0.79659148792642	0.833925332311019	NA	NA	0.760128299493592	0.730854717097631	NA	NA	p.Asn35Ser	1	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.397	-2.497	0.1	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35T	35	N	T	missense	wt-like	1.0972635762659	0.182381143077533	6	0.0744567898742482	0.95133094970791	1.2431962028239	0.918198738419487	1.00077469343633	1.30425851479068	1.32171781690453	NA	NA	0.920417468914568	1.11821422512983	0.699106324596867	0.668855615650949	0.673706881521465	0.808774929781733	0.830890420434144	NA	NA	0.675066262739608	0.723146386454126	NA	NA	p.Asn35Thr	1	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.397	-2.673	0.276	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35V	35	N	V	missense	wt-like	0.925441274554911	0.177318825736526	6	0.0723901074739965	0.783559271068894	1.06732327804093	1.09407088119477	1.06916782972113	0.795797193368065	0.642465071374966	NA	NA	1.0312823854506	0.919864286219934	0.683515737356802	0.706316165713828	0.688494282543136	0.656635673992718	0.605919280693019	NA	NA	0.697871738645978	0.678537192170468	NA	NA	p.Asn35Val	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.397	-3.55	1.153	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35W	35	N	W	missense	wt-like	0.987702790327828	0.0982587005555662	6	0.0401139465250105	0.909080899861042	1.06632468079461	0.918480375731099	1.03473119054154	1.00476047365392	1.15367804998985	NA	NA	0.923049051624405	0.891517600426159	0.67832813425265	0.668915604051868	0.681048675848529	0.719160622519722	0.775234998894178	NA	NA	0.675607592656772	0.672161980658824	NA	NA	p.Asn35Trp	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.397	-5.94	3.543	0.008629843	NA	NA	NA	NA	NA	NA	NA
N35X	35	N	X	nonsense	low	0.628849701463708	0.053472890710379	6	0.0218302162186732	0.586063263900387	0.67163613902703	0.650451113911693	0.72322327843181	0.59116064180246	0.58539523585803	NA	NA	0.588979728046932	0.633888210731324	0.609356769294389	0.611825700999219	0.613696998940369	0.595405347612504	0.587017530165572	NA	NA	0.606887837589558	0.614220750319965	NA	NA	p.Asn35Ter	0	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N35Y	35	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn35Tyr	1	12.8	-2.1	17.5	0.477	111.4	-117.6	-86.9	-4.1	59.3582887700535	-3.5	1	0	20.14	0	0	0	0	7	15.0633709618909	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.397	-4.742	2.345	0.008629843	NA	NA	NA	NA	NA	NA	NA
G36A	36	G	A	missense	wt-like	1.09343796518683	0.091961860007524	6	0.0375432721359488	1.01985450393858	1.16702142643507	1.0561229727393	1.16410534074439	0.988224461022332	1.23671093264083	NA	NA	1.08732749168729	1.02813659228681	0.709210695596967	0.698233307894246	0.709020889798783	0.714212799451394	0.802735811174913	NA	NA	0.709400501395151	0.702887793755836	NA	NA	p.Gly36Ala	1	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.818	-2.797	0.979	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36C	36	G	C	missense	wt-like	1.11687569017894	0.0659539361522923	6	0.0269255816835361	1.06410251981642	1.16964886054147	1.02975082632264	1.08869565574327	1.10749481456275	1.12452018125057	NA	NA	1.23182762704595	1.11896503614848	0.731220078726942	0.692616073149066	0.692716428362978	0.749900278637739	0.765577799853217	NA	NA	0.739124912492489	0.723315244961395	NA	NA	p.Gly36Cys	1	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.818	-4.355	2.537	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36D	36	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Asp	1	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.818	-2.595	0.777	0.008193478	NA	NA	NA	NA	8.12e-06	NA	NA
G36E	36	G	E	missense	wt-like	1.10604185281677	0.178117778372081	6	0.0727162785216232	0.963520565824608	1.24856313980894	1.16324855900541	1.1046958904828	1.152252518059	1.33925947658114	NA	NA	1.08437685998195	0.792417812790327	0.714922233734769	0.721050925988914	0.696175867429334	0.763292455021371	0.836700286049516	NA	NA	0.708793541480624	0.649874292019181	NA	NA	p.Gly36Glu	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.818	-2.689	0.871	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36F	36	G	F	missense	possibly_wt-like	0.831935791260392	0.270472127916374	6	0.110419783839983	0.615516991753328	1.04835459076746	0.709796119097759	0.332845415768895	0.999813867936889	1.03920183668576	NA	NA	0.941841899742396	0.968115608330659	0.684431181336183	0.624466114100883	0.529292710458253	0.717680523875512	0.737320033736117	NA	NA	0.679473376877406	0.68938898579496	NA	NA	p.Gly36Phe	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.818	-4.816	2.998	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36G	36	G	G	synonymous	possibly_wt-like	0.792861278665481	0.156775055097625	6	0.0640031482309834	0.667417413235575	0.918305144095387	0.66534284414486	1.00434968313983	0.979215155301963	0.708295832072578	NA	NA	0.662755613249454	0.737208544084204	0.632590164746792	0.614997621219895	0.674479836371405	0.711517080013703	0.627722683567189	NA	NA	0.622063911545383	0.637457645926394	NA	NA	p.Gly36=	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36H	36	G	H	missense	wt-like	1.23591305248237	0.280057004802579	6	0.114332793443083	1.01182489508207	1.46000120988266	0.714110646725432	1.11298586790668	1.3721867424993	1.40577480919105	NA	NA	1.40172771792946	1.40869253064227	0.781274804909709	0.625385103178083	0.697968258117737	0.829100074635901	0.858730421792059	NA	NA	0.774074223331275	0.788475386488142	NA	NA	p.Gly36His	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.818	-3.096	1.278	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36I	36	G	I	missense	possibly_wt-like	0.825768879399672	0.233548554790274	5	0.104446088911577	0.621058306806913	1.03047945199243	0.540887201060771	0.601878339647681	1.00048277799455	NA	NA	NA	1.00972048814897	0.975875590146385	0.691134217169155	0.588488722341484	0.587460794999102	0.71788067180039	NA	NA	NA	0.693436346956956	0.691134217169155	NA	NA	p.Gly36Ile	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.818	-4.567	2.749	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36K	36	G	K	missense	possibly_wt-like	0.885191708641879	0.274783413067599	6	0.112179858632673	0.665323225931046	1.10506019135271	1.19913390201204	1.2231914411044	0.779565870401165	0.698863298965121	NA	NA	0.540796771025429	0.869598968343116	0.659505733283105	0.728694459905146	0.721796000113828	0.651779018643308	0.6245985920743	NA	NA	0.59697635882978	0.667232447922902	NA	NA	p.Gly36Lys	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.818	-2.534	0.716	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36L	36	G	L	missense	possibly_wt-like	0.804108920747162	0.19776251177268	6	0.080736207349036	0.645868862094694	0.962348979399631	0.789751358166582	0.847893036786289	0.540363370699647	0.697393464906195	NA	NA	1.13943621087709	0.809816083047167	0.641074274835198	0.641496481665997	0.640652068004398	0.580206041989665	0.624111777342018	NA	NA	0.720119529353906	0.653787188702449	NA	NA	p.Gly36Leu	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.818	-4.09	2.272	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36M	36	G	M	missense	wt-like	1.04633168820958	0.137866138853582	6	0.0562836154998283	0.936017828910214	1.15664554750894	0.839079491794018	1.07467335473165	1.20025614240011	1.15786141601695	NA	NA	1.07856522153412	0.927554502780613	0.698641349904611	0.652003313447878	0.689684641847998	0.777655859620168	0.776620545922534	NA	NA	0.707598057961223	0.68026673323574	NA	NA	p.Gly36Met	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.818	-4.263	2.445	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36N	36	G	N	missense	possibly_low	0.719342089186526	0.445664626992842	5	0.199307280224616	0.328706998089646	1.10997718028341	1.02407315527581	0.998420429599805	1.10110098026244	NA	NA	NA	0.159677589451433	0.313438291343137	0.673197861971367	0.691406736200451	0.673197861971367	0.747987147488717	NA	NA	NA	0.518578209222044	0.542151090048157	NA	NA	p.Gly36Asn	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.818	-1.908	0.09	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36P	36	G	P	missense	wt-like	0.908786909790327	0.183928190382433	6	0.0750883692917404	0.761616410320672	1.05595740925998	0.987762014589728	1.10913018362751	0.671566775690567	0.692457113388994	NA	NA	0.948346866567619	1.04345850487754	0.68224199473228	0.683672507902287	0.697134613796886	0.619464069200967	0.622476838603387	NA	NA	0.680811481562274	0.706333714532588	NA	NA	p.Gly36Pro	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.818	-3.453	1.635	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36Q	36	G	Q	missense	wt-like	0.978797422655379	0.159568413326679	6	0.0651435319526476	0.851118446202456	1.1064763991083	1.2722252955013	1.03438394373575	0.81900682006171	0.916813918471961	NA	NA	0.897141509562153	0.933213048599399	0.681256472775973	0.744262836805338	0.680973597002178	0.663580342512307	0.696784681273706	NA	NA	0.670278279788874	0.681539348549767	NA	NA	p.Gly36Gln	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.818	-2.84	1.022	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36R	36	G	R	missense	wt-like	1.08751776923237	0.124705622428216	6	0.0509108571675511	0.987734322761907	1.18730121570283	1.00520048251464	1.03248796284509	1.24015181211546	1.24217053677682	NA	NA	1.05866681435863	0.946429006783578	0.69544586737542	0.687386880118446	0.680563663618763	0.789593242551705	0.804544053207193	NA	NA	0.703504854632394	0.684511637069355	NA	NA	p.Gly36Arg	1	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.818	-2.613	0.795	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36S	36	G	S	missense	wt-like	1.03023048192641	0.377049971181536	6	0.153930006154311	0.728533213723928	1.33192775012888	0.482654818525761	0.652195690048996	1.18553189682897	1.23806841368432	NA	NA	1.4573803663379	1.16555170613249	0.753521400150784	0.576085296495807	0.598339998368775	0.773250144438175	0.803185414153391	NA	NA	0.785522255513681	0.733792655863393	ND	*30	p.Gly36Ser	1	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.818	-2.845	1.027	0.008193478	1.124600639	0.028480012701959	1.1	0.09	3.25e-05	NA	NA
G36T	36	G	T	missense	wt-like	1.02440737056701	0.110840775958773	6	0.045250557298857	0.935717907980881	1.11309683315313	1.05836156753452	1.00221876685658	0.837433516496775	1.06208797425459	NA	NA	1.17667924728093	1.00966315097864	0.698721607673303	0.698710125831833	0.674019107191027	0.669093886540468	0.744900011126005	NA	NA	0.727780610928902	0.698733089514772	NA	NA	p.Gly36Thr	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.818	-3.576	1.758	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36V	36	G	V	missense	wt-like	0.911560308468355	0.0935312776476636	6	0.0381839842045596	0.836721074641172	0.986399542295538	0.915294602552643	1.07682527984801	0.925852796513304	0.903454014705578	NA	NA	0.803979033021875	0.843956124168717	0.67919347583459	0.66823703828382	0.690149913385361	0.695550261671379	0.692359829409748	NA	NA	0.651114285619208	0.661465334385847	NA	NA	p.Gly36Val	1	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.818	-4.195	2.377	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36W	36	G	W	missense	wt-like	1.00896733039735	0.0195355758854823	6	0.00797536545847521	0.993335901335191	1.0245987594595	0.975633259253597	1.01677069395693	1.00343775093837	1.01965080127417	NA	NA	1.0053025668848	1.03300891007622	0.69825557167955	0.68108909793582	0.677165405099854	0.718764844038487	0.730844655095969	NA	NA	0.692527558134539	0.703983585224561	NA	NA	p.Gly36Trp	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.818	-5.883	4.065	0.008193478	NA	NA	NA	NA	NA	NA	NA
G36X	36	G	X	nonsense	low	0.436392288286603	0.238024065127769	6	0.0971729176776709	0.245936869365693	0.626847707207514	0.539484829669525	0.765332603434309	0.249035611472924	0.480355899078747	NA	NA	0.0850027343077931	0.49914205175632	0.568072117581362	0.588190018960269	0.622801530613998	0.493036405653461	0.552228095057048	NA	NA	0.503217212587581	0.583916140105675	NA	NA	p.Gly36Ter	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G36Y	36	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Tyr	0	14.5	-0.6	20.5	0.67	67.4	141.1	76	17.8	56.701030927835	-3.5	0	0	19.29	0	0	0	0	6	14.1227945730907	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.818	-4.714	2.896	0.008193478	NA	NA	NA	NA	NA	NA	NA
K37A	37	K	A	missense	wt-like	1.0105562171909	0.132327606265876	6	0.0540225190392192	0.904674025519897	1.1164384088619	0.878387788393633	0.913857606277205	0.898465569935882	1.04637903239766	NA	NA	1.15022734150927	1.17601996463173	0.704847456136948	0.660375932268688	0.654914384302076	0.687355592590246	0.739697148749752	NA	NA	0.722339319683651	0.736146982664656	NA	NA	p.Lys37Ala	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.39	-2.95	0.56	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37C	37	K	C	missense	wt-like	0.972948853254889	0.170863496441048	6	0.0697547303247362	0.836232094067102	1.10966561244268	0.901863713439199	0.963016695204812	1.00446767839432	1.22187997910399	NA	NA	0.702978167140383	1.04348688624663	0.685941627726667	0.665376275424599	0.665543157908909	0.719073013785257	0.797823741930305	NA	NA	0.630337894986791	0.706340097544425	NA	NA	p.Lys37Cys	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.39	-5.604	3.214	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37D	37	K	D	missense	possibly_wt-like	0.791110231007487	0.136824395080536	6	0.0558583253853811	0.681629925015421	0.900590536999553	0.823613398295553	0.988961146440409	0.84229898028109	0.763347616157579	NA	NA	0.758586124474733	0.569854120395558	0.647332551101837	0.648709054558244	0.671152653620736	0.670549706301041	0.64595604764543	NA	NA	0.641776733988477	0.599819388805742	NA	NA	p.Lys37Asp	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.39	-2.488	0.098	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37E	37	K	E	missense	wt-like	1.20000111775649	0.23379299632307	6	0.0954455910713177	1.01293119677357	1.38707103873941	0.897845919307233	1.00383323216432	1.18253644544929	1.18269475959293	NA	NA	1.44633641994862	1.48675993007655	0.777802160072288	0.66452049021696	0.674368173592102	0.772353860444768	0.784845445482586	NA	NA	0.783250459699808	0.806032859950062	NA	NA	p.Lys37Glu	1	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.39	-2.098	-0.292	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37F	37	K	F	missense	possibly_low	0.695101187619177	0.381660143947906	6	0.155812101304925	0.389715080706018	1.00048729453233	1.21273634675325	1.01411196519288	0.550988639402138	0.593313411164079	NA	NA	0.123152057458474	0.676304705744233	0.606700171600302	0.731591763902044	0.676590556649008	0.583385281795817	0.589640060490249	NA	NA	0.511064721945282	0.623760282710354	NA	NA	p.Lys37Phe	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.39	-4.779	2.389	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37G	37	K	G	missense	wt-like	1.08654638368234	0.0631220541372219	6	0.0257694706920882	1.03603914922519	1.1370536181395	0.971773068088045	1.09341525705862	1.1097760584921	1.09113960163991	NA	NA	1.16489270940464	1.08828160741075	0.720885278393756	0.680266881966152	0.693736861714972	0.750582861046789	0.754522022619111	NA	NA	0.725356060277931	0.71641449650958	NA	NA	p.Lys37Gly	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.39	-3.505	1.115	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37H	37	K	H	missense	wt-like	1.14553021958835	0.201657803023219	6	0.0823264533429274	0.984173336061299	1.30688710311541	0.966879629543536	0.868230784787021	1.41565654155009	1.13412607268518	NA	NA	1.21275432935708	1.27553395960723	0.746864632759452	0.679224585575811	0.645049328488435	0.842106890687084	0.768759308295391	NA	NA	0.735201438372006	0.758527827146898	NA	NA	p.Lys37His	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.39	-3.212	0.822	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37I	37	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys37Ile	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.39	-3.689	1.299	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37L	37	K	L	missense	wt-like	1.06306629519806	0.145327049261973	6	0.0593295194193579	0.946782573916048	1.17935001648007	1.06467075045474	1.02840763031798	1.1450469690143	1.20771022156649	NA	NA	0.795960058142844	1.136602141692	0.713667915043049	0.700053974032629	0.679681447702696	0.76113644664271	0.793130663361176	NA	NA	0.649464741794962	0.727281856053469	NA	NA	p.Lys37Leu	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.39	-3.424	1.034	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37M	37	K	M	missense	wt-like	1.14932929018183	0.4097225699136	6	0.167268538731688	0.821488978521079	1.47716960184258	0.553059876439362	0.759243048488239	1.21515035599074	1.41732400410589	NA	NA	1.62154563544522	1.32965282062153	0.776405835361273	0.591081487222967	0.621484897163295	0.782112431783613	0.862555559872375	NA	NA	0.819291884412222	0.770699238938934	NA	NA	p.Lys37Met	1	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.39	-3.773	1.383	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37N	37	K	N	missense	possibly_wt-like	0.825458234396464	0.302530296076259	2	0.213921223869897	0.406180340082736	1.24473612871019	1.03937945826636	0.611537010526567	NA	NA	NA	NA	NA	NA	0.642108036614927	0.694666959908464	0.589549113321391	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys37Asn	1	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.39	-2.54	0.15	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37P	37	K	P	missense	wt-like	0.998909768894441	0.0331146463218891	6	0.0135189977502267	0.972413020196918	1.02540651759196	1.01964618091517	1.03456060231675	1.00015937737243	0.970497693858872	NA	NA	1.01997697388813	0.948617785015301	0.693004977113325	0.690463796107454	0.681011792666582	0.717783905482286	0.714564955573494	NA	NA	0.695546158119196	0.685003896527156	NA	NA	p.Lys37Pro	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.39	-3.817	1.427	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37Q	37	K	Q	missense	possibly_wt-like	0.877766588078906	0.198671763455891	6	0.0811074077943085	0.718798989922658	1.03673418623515	0.853740229471289	1.12894570065148	0.782888339467545	1.10331001835355	NA	NA	0.628873418674552	0.768841821855027	0.653949591886553	0.655126032538302	0.701418961797318	0.652773151234803	0.758552911764883	NA	NA	0.615094172188914	0.644572016828966	NA	NA	p.Lys37Gln	1	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.39	-2.122	-0.268	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37R	37	K	R	missense	wt-like	0.938154721595092	0.155025255147351	6	0.0632887953926304	0.814110962000612	1.06219848118957	0.957957397611706	1.01612507078958	1.00872375928656	1.12781669522241	NA	NA	0.824946049991593	0.693359356668709	0.677174987461173	0.677324161149972	0.677025813772375	0.720346497041981	0.766669618046514	NA	NA	0.655427307405283	0.627595898898143	NA	NA	p.Lys37Arg	1	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.39	-2.175	-0.215	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37S	37	K	S	missense	wt-like	0.994545301887616	0.0835074004938655	6	0.0340917534927017	0.927726692872103	1.06136391090313	1.05305897955027	1.00835156214971	0.89879425703811	1.07349368587886	NA	NA	1.05137617936888	0.882197147339854	0.692517310908325	0.697580681114141	0.675345089713684	0.687453940702508	0.748677626984841	NA	NA	0.702005134019275	0.670065796990587	NA	NA	p.Lys37Ser	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.39	-3.126	0.736	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37T	37	K	T	missense	wt-like	1.11203700753405	0.130236131410445	6	0.0531686780049412	1.00782831353875	1.21624570152934	0.87952579981323	1.09961826165195	1.23966797985478	1.10947061276464	NA	NA	1.23159962509642	1.11233976602326	0.7304516116286	0.660618327301143	0.695078024314663	0.789448472680398	0.760593324490879	NA	NA	0.739078011334492	0.721825211922706	NA	NA	p.Lys37Thr	1	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.39	-3.315	0.925	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37V	37	K	V	missense	wt-like	1.01963554533278	0.0711683004420036	6	0.0290543369906666	0.962690091236384	1.07658099942918	1.0133199116693	0.998214959764359	1.021253984336	0.941169996651909	NA	NA	1.15316023326586	0.99069418630926	0.699659225012052	0.689116308540313	0.673153436974654	0.724095728367103	0.704851508686372	NA	NA	0.722942630400698	0.694466941337732	NA	NA	p.Lys37Val	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.39	-3.254	0.864	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37W	37	K	W	missense	wt-like	0.888084376193495	0.130657212915667	6	0.0533405838095939	0.78353875301235	0.992629999374639	0.83167785100304	0.949761513444644	0.746285219495505	0.760128027444768	NA	NA	0.961527104984047	1.07912654078896	0.65655200233462	0.650426773064492	0.662677231604748	0.64182094858442	0.644889707395816	NA	NA	0.68352272348657	0.714355508501538	NA	NA	p.Lys37Trp	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.39	-5.89	3.5	0.007344423	NA	NA	NA	NA	NA	NA	NA
K37X	37	K	X	nonsense	low	0.481519436799708	0.238312160587897	6	0.0972905321567586	0.290833497735725	0.67220537586369	0.733594812185759	0.718718231401804	0.368988685602521	0.615154393209107	NA	NA	0.185137701887987	0.267522796511067	0.564349252876311	0.629535206452782	0.612722954750075	0.528928165082912	0.596873878323264	NA	NA	0.523815483545491	0.531824627429358	NA	NA	p.Lys37Ter	1	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K37Y	37	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys37Tyr	0	18	-0.9	18.9	0.585	22.2	123.8	-92.8	73.6	66.0869565217391	-2.8	0	0	17.69	0	0	0	0	5	12.7133723159761	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.39	-4.665	2.275	0.007344423	NA	NA	NA	NA	NA	NA	NA
T38A	38	T	A	missense	wt-like	0.879206779354938	0.154753562847332	6	0.0631778774756151	0.755380414883048	1.00303314382683	0.804689692319163	0.92119201813009	0.982147896694414	1.05621636066121	NA	NA	0.61426977141357	0.896724936911179	0.664916644397281	0.644678328464178	0.656500170467446	0.712394600238095	0.742955309965919	NA	NA	0.612090127842322	0.673333118327115	NA	NA	p.Thr38Ala	1	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.622	-2.835	1.213	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38C	38	T	C	missense	wt-like	0.89351994766465	0.15824427002779	6	0.064602952714547	0.766900487049193	1.02013940828011	0.933431194305797	0.810258351895638	0.841642526892057	1.10327431242263	NA	NA	1.01435004323351	0.658163257238258	0.671226697807454	0.672100110016602	0.632515006187482	0.670353285598306	0.758541085822293	NA	NA	0.694388669930144	0.619680244140956	NA	NA	p.Thr38Cys	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.622	-3.949	2.327	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38D	38	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr38Asp	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.622	-3.556	1.934	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38E	38	T	E	missense	possibly_wt-like	0.741616348936245	0.137535318921124	6	0.0561485588279512	0.631567195849632	0.851665502022858	0.775742917482222	0.831186032805808	0.816729562380446	0.885773817992447	NA	NA	0.56130285138101	0.578962911575536	0.637776259071215	0.638512701032643	0.637039817109788	0.662898952848491	0.686504079791394	NA	NA	0.601194563615342	0.601867969398557	NA	NA	p.Thr38Glu	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.622	-4.107	2.485	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38F	38	T	F	missense	wt-like	1.01143561276984	0.204908720512361	6	0.0836536348503087	0.847477501287368	1.17539372425231	0.682045644353117	0.851587554377111	1.02424752022869	1.17191411383703	NA	NA	1.16394029869181	1.17487854513127	0.725075791889717	0.618555297117386	0.641450866190368	0.724991439218062	0.781274853859936	NA	NA	0.725160144561373	0.73589027573278	NA	NA	p.Thr38Phe	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.622	-4.265	2.643	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38G	38	T	G	missense	possibly_low	0.700640946169796	0.111106565104777	6	0.0453590652633371	0.611738811881253	0.789543080458339	0.782647968111805	0.884946037534809	0.665419962757416	0.587417859935281	NA	NA	0.645127663215385	0.63828618546408	0.618031301661419	0.63998346832253	0.648663362863622	0.617624850551046	0.587687431092615	NA	NA	0.618437752771792	0.6152098613345	NA	NA	p.Thr38Gly	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.622	-4.007	2.385	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38H	38	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr38His	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.622	-5.262	3.64	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38I	38	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr38Ile	1	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.622	-1.321	-0.301	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38K	38	T	K	missense	wt-like	0.881215441608791	0.140404070849552	6	0.0573197218984966	0.768870851083885	0.993560032133696	0.894893487852229	0.941494732122777	0.632061214542101	1.05606212399394	NA	NA	0.849013229339934	0.913767861801758	0.662390741067786	0.663891625948963	0.660889856186609	0.607643412605419	0.742904226184436	NA	NA	0.66037804832416	0.677166097312559	NA	NA	p.Thr38Lys	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.622	-4.125	2.503	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38L	38	T	L	missense	wt-like	0.993470348724993	0.0843447259888281	6	0.034433590194582	0.9259817520852	1.06095894536478	0.990548355274578	1.03005799462724	0.843815044100389	1.01942024295356	NA	NA	1.09806909943103	0.978911355963159	0.688041480213324	0.684265995040556	0.680038275890414	0.671003335341204	0.73076829328734	NA	NA	0.711610104615444	0.691816965386092	NA	NA	p.Thr38Leu	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.622	-2.404	0.782	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38M	38	T	M	missense	possibly_wt-like	0.736013633012278	0.214423051270059	6	0.0875378441170467	0.564442611258585	0.907584654765971	0.868508114556481	1.01292128504294	0.48328909308551	0.576453346004529	NA	NA	0.585270460184839	0.889639499199368	0.632198198131379	0.658271573894807	0.676333117586813	0.563128561845028	0.58405594161842	NA	NA	0.606124822367951	0.671739592918395	NA	NA	p.Thr38Met	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.622	-3.807	2.185	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38N	38	T	N	missense	possibly_wt-like	0.851652084215948	0.215758368406128	6	0.0880829850550741	0.679012605857223	1.02429156257467	1.10760506153386	0.898974091982146	0.53739848023018	0.969095142484335	NA	NA	0.645463121152087	0.951376607913084	0.668660376605801	0.709198929477048	0.651696393339119	0.579318902279099	0.714100425126835	NA	NA	0.618506758171625	0.685624359872483	NA	NA	p.Thr38Asn	1	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.622	-4.301	2.679	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38P	38	T	P	missense	possibly_wt-like	0.848323452580303	0.171934911209331	6	0.0701921335722654	0.710749398780638	0.985897506379968	1.06952789114096	1.0555902828373	0.768863609128102	0.809131315262011	NA	NA	0.687362365462937	0.699465251650508	0.654848263796081	0.701088539023805	0.685558657105144	0.648576741504925	0.661119786087236	NA	NA	0.627125645340639	0.628969123699803	NA	NA	p.Thr38Pro	1	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.622	-3.389	1.767	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38Q	38	T	Q	missense	wt-like	0.999181675491222	0.187336641855113	6	0.0764798637785907	0.849283896942655	1.14907945403979	0.61818735245153	1.06495206506357	1.08570051519658	1.07823283332479	NA	NA	1.09702953751452	1.05098774939634	0.709711657100941	0.604953559497313	0.68758278460649	0.743379097288617	0.750247250971388	NA	NA	0.711396261454045	0.708027052747837	NA	NA	p.Thr38Gln	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.622	-4.554	2.932	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38R	38	T	R	missense	wt-like	0.955793178053212	0.0510444972690754	6	0.0208388287476873	0.914949824227747	0.996636531878677	0.978447895791401	0.973907236844811	0.976336308795785	1.01880789204831	NA	NA	0.899327207460177	0.887932527378785	0.676522152245097	0.681688612055961	0.667897821188325	0.710655685947867	0.73056548029618	NA	NA	0.670727888937641	0.671355692434233	NA	NA	p.Thr38Arg	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.622	-4.411	2.789	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38S	38	T	S	missense	wt-like	0.925362162813122	0.0837509906185387	6	0.0341911987446735	0.858348644685311	0.992375680940933	0.844230404403361	0.939421548564917	0.99243228196759	0.94680003149392	NA	NA	0.807165548705302	1.02212316174364	0.680988486921986	0.653100451497298	0.660441609500948	0.715471842607939	0.706716198028484	NA	NA	0.651769768065001	0.701535364343023	NA	NA	p.Thr38Ser	1	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.622	-3.776	2.154	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38T	38	T	T	synonymous	possibly_wt-like	0.759715804393777	0.210689780143078	5	0.0942233341128816	0.575041463029244	0.944390145758309	0.518420162672424	0.885758037631821	1.05477270647542	NA	NA	NA	0.680474238936842	0.659153876252372	0.625708722760989	0.583703270802484	0.648838926841477	0.734125032910904	NA	NA	NA	0.625708722760989	0.619903035820674	NA	NA	p.Thr38=	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38V	38	T	V	missense	possibly_low	0.693984221416224	0.147362054728574	6	0.0601603069221825	0.576072186549871	0.811896256282578	0.828348388241338	0.828872458897452	0.512624151341892	0.557360487921414	NA	NA	0.619394335749841	0.817305506345408	0.624841935965768	0.649717601591972	0.636539595201062	0.571906051387726	0.577732313083764	NA	NA	0.613144276730474	0.655471571066366	NA	NA	p.Thr38Val	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.622	-2.251	0.629	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38W	38	T	W	missense	wt-like	0.883813991722416	0.105452239386649	6	0.0430506964551855	0.799436177160887	0.968191806283946	0.922049549292788	1.03071470610925	0.782874883019179	0.753828258893751	NA	NA	0.953749775484391	0.859666777535142	0.667337258583623	0.669675833629906	0.680180264642027	0.652769124863566	0.642803199655722	NA	NA	0.681922887343071	0.66499868353734	NA	NA	p.Thr38Trp	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.622	-5.687	4.065	0.005258479	NA	NA	NA	NA	NA	NA	NA
T38X	38	T	X	nonsense	possibly_low	0.577090013535973	0.216172723637771	6	0.0882521448700373	0.404118988032289	0.750061039039658	0.672445397123575	0.948433370285356	0.436533621358875	0.525470190743105	NA	NA	0.324584053599464	0.555073448105466	0.581832658467292	0.61651045626719	0.662390071422054	0.549138623234452	0.567170123162406	NA	NA	0.552500305701593	0.596495193772179	NA	NA	p.Thr38Ter	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T38Y	38	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr38Tyr	0	19.2	2.5	20.2	0.245	12.9	142.2	-129.9	40.6	15.3374233128834	-3.9	0	0	16.48	0	0	0	0	6	10.2855608946404	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.622	-4.487	2.865	0.005258479	NA	NA	NA	NA	NA	NA	NA
A39A	39	A	A	synonymous	wt-like	1.09713582771273	0.176774716441703	6	0.0721679757845595	0.955689194337838	1.23858246108763	0.798399478549134	1.0431164492129	1.0823124589763	1.10822107444834	NA	NA	1.26542145443644	1.28534405065329	0.74420033664625	0.643338520669037	0.682861667464056	0.742365340036672	0.760179472561656	NA	NA	0.746035333255828	0.760734131115628	NA	NA	p.Ala39=	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39C	39	A	C	missense	wt-like	1.2815578857018	0.275758497180071	6	0.112577935054648	1.0609091875408	1.5022065838628	1.17008110952758	0.92268968621874	1.12848071109431	1.25279402113543	NA	NA	1.57550274116914	1.6397990450656	0.782121083048386	0.722506250845106	0.656823983935102	0.756179573730322	0.808062592366449	NA	NA	0.809820627418751	0.840451582996137	NA	NA	p.Ala39Cys	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.186	-5.394	3.208	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39D	39	A	D	missense	possibly_low	0.699284970361012	0.458395112247407	5	0.20500052630777	0.297491321986028	1.101078618736	1.19266423716422	1.15895334525692	0.15230614679448	NA	NA	NA	0.450674120129795	0.541827002459653	0.593516048577431	0.727316429251186	0.707906967737689	0.464093498594427	NA	NA	NA	0.578437672220562	0.593516048577431	NA	NA	p.Ala39Asp	1	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.186	-3.022	0.836	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39E	39	A	E	missense	possibly_low	0.631184581711115	0.463115272359088	4	0.231557636179544	0.177339954453979	1.08502920896825	0.542051916561488	0.313669015014391	0.359121956573184	NA	NA	NA	1.3098954386954	NA	0.557356348518834	0.588736805310368	0.525146546917393	0.5259758917273	NA	NA	NA	0.755183857497473	NA	NA	NA	p.Ala39Glu	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.186	-3.443	1.257	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39F	39	A	F	missense	wt-like	1.11245884997543	0.281343232055473	6	0.114857893520225	0.88734151533565	1.3375761846152	0.755259180388452	0.766739489237409	1.25388560879006	1.27933848304776	NA	NA	1.41687885535142	1.20265148303746	0.75966366983954	0.634149690229639	0.62310571588305	0.7937026005642	0.816854220945848	NA	NA	0.777190889182172	0.742136450496907	NA	NA	p.Ala39Phe	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.186	-3.859	1.673	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39G	39	A	G	missense	wt-like	0.989307914770414	0.0182623541471174	6	0.00745557486040631	0.974695256559976	1.00392057298085	1.01331637508347	0.990895894940612	0.992429890276519	0.991100034995735	NA	NA	0.991520262575569	0.956585030750582	0.689404011726421	0.689115555251882	0.671570969017612	0.715471126978088	0.721388530741059	NA	NA	0.689692468200959	0.686795741863051	NA	NA	p.Ala39Gly	1	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.186	-1.34	-0.846	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39H	39	A	H	missense	possibly_wt-like	0.853402981818583	0.382213112408496	4	0.191106556204248	0.478841014448778	1.22796494918839	0.753707082384884	1.23411370969503	1.06210610030242	0.363685034892003	NA	NA	NA	NA	0.678988309198782	0.633819095264185	0.72415752313338	0.736319294366476	0.513586253027818	NA	NA	NA	NA	NA	NA	p.Ala39His	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.186	-3.172	0.986	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39I	39	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Ile	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.186	-3.551	1.365	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39K	39	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Lys	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.186	-3.035	0.849	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39L	39	A	L	missense	wt-like	1.05387015075317	0.125965869249422	6	0.051425350777871	0.953078315336204	1.15466198617014	0.866248350560532	0.974243459931356	1.09542186599167	1.15540052995996	NA	NA	1.21095608931516	1.02095060876035	0.718051593357613	0.657790246943507	0.667970516576832	0.746287871295439	0.77580549093062	NA	NA	0.734831531270361	0.701271655444864	NA	NA	p.Ala39Leu	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.186	-3.954	1.768	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39M	39	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Met	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.186	-5.15	2.964	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39N	39	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Asn	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.186	-3.054	0.868	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39P	39	A	P	missense	wt-like	0.944044683583439	0.1362151316719	6	0.0556095946403632	0.835051880893455	1.05303748627342	0.700391692762757	1.11481853070404	1.00276117101437	0.961201066367585	NA	NA	0.926801787173987	0.958293853477893	0.692772280001513	0.622462982860337	0.698364501384155	0.718562401174533	0.711485876546978	NA	NA	0.676379549402269	0.687180058618872	NA	NA	p.Ala39Pro	1	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.186	-2.979	0.793	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39Q	39	A	Q	missense	wt-like	1.03687467499219	0.140977992429366	6	0.0575540244023161	0.924070859998307	1.14967848998606	0.933704623766959	1.14488031478006	1.01428286991508	1.16291855239419	NA	NA	0.8171951435443	1.14826654555253	0.713437039630176	0.672158350155472	0.704864212915263	0.722009866345088	0.778295489074549	NA	NA	0.653832906617737	0.729905197713553	NA	NA	p.Ala39Gln	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.186	-3.732	1.546	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39R	39	A	R	missense	wt-like	0.874968141108189	0.0991477807045889	6	0.0404769119759344	0.795634851429959	0.954301430786418	0.899082135738515	1.02949425871188	0.825677492574054	0.933381833667207	NA	NA	0.756364332101686	0.805808793855788	0.665180055301929	0.664783802796097	0.679916389550592	0.665576307807761	0.702272038946	NA	NA	0.641319700023038	0.65288594344333	NA	NA	p.Ala39Arg	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.186	-3.152	0.966	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39S	39	A	S	missense	wt-like	1.03065385592674	0.25641989896825	6	0.104682985394705	0.825478974758982	1.23582873709449	0.592913465866586	0.865726672913425	1.18777136576854	1.28871804645698	NA	NA	1.14763128800571	1.10116229654916	0.720558340414994	0.599570252745268	0.644507910029077	0.773920227143532	0.819960768669555	NA	NA	0.721805298304508	0.719311382525481	NA	NA	p.Ala39Ser	1	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.186	-2.399	0.213	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39T	39	A	T	missense	wt-like	1.09103679825096	0.350322005709116	6	0.143018359942618	0.810725963635443	1.37134763286648	0.511946351096022	0.814310083344593	1.34596452386895	1.34431557773054	NA	NA	1.34278200051546	1.18690225295019	0.750271607763961	0.582324356900438	0.633391038213829	0.821253993411088	0.838374886330065	NA	NA	0.761948790144015	0.738594425383907	NA	NA	p.Ala39Thr	1	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.186	-3.142	0.956	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39V	39	A	V	missense	possibly_wt-like	0.839499323463601	0.263367978021048	6	0.107519526790017	0.628764923320378	1.05023372360682	0.724056739279489	1.21987315172365	0.602375854274449	1.12358161202551	NA	NA	0.643340938159406	0.723767645319097	0.630969188297405	0.62750360865696	0.721078546894915	0.598761107445386	0.765266942091246	NA	NA	0.618070214361187	0.634434767937851	NA	NA	p.Ala39Val	1	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.186	-3.997	1.811	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39W	39	A	W	missense	wt-like	0.822688203505431	0.107004602650852	6	0.0436844461039753	0.737068262457059	0.908308144553804	0.956111665341076	0.811088508573608	0.79629001155597	0.79529961066212	NA	NA	0.655342976893816	0.921996448005997	0.656660902274213	0.676931022446846	0.632694495831835	0.656783132588265	0.656538671960161	NA	NA	0.620539094632215	0.679016718506002	NA	NA	p.Ala39Trp	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.186	-3.865	1.679	0.005248321	NA	NA	NA	NA	NA	NA	NA
A39X	39	A	X	nonsense	low	0.423206828934459	0.196515023038769	3	0.113458001451239	0.200833232332138	0.64558042553678	0.639882808130371	NA	0.373236589931735	0.25650108874127	NA	NA	NA	NA	0.530199201789306	0.609574664868347	NA	0.530199201789306	0.478086514990422	NA	NA	NA	NA	NA	NA	p.Ala39Ter	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A39Y	39	A	Y	missense	wt-like	1.23231760956853	0.23554892459411	6	0.0961624457861467	1.0438426791624	1.42079253997467	1.18709188925733	0.802218978409369	1.22749313014647	1.47548364969736	NA	NA	1.39051329219913	1.31110471770155	0.76914755112147	0.726129526001815	0.630776799019888	0.78580557498902	0.881818259716822	NA	NA	0.771767359051864	0.766527743191075	NA	NA	p.Ala39Tyr	0	22.4	1.6	22.1	0.671	63.5	74.1	-65.3	-14.8	52.8925619834711	-0.5	0	0	17.08	0	0	0	0	4	12.3928989641463	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.186	-4.593	2.407	0.005248321	NA	NA	NA	NA	NA	NA	NA
F40A	40	F	A	missense	possibly_low	0.607298037538491	0.194574901154777	6	0.0794348707636127	0.451608551725216	0.762987523351765	0.793001162548771	0.884771344505394	0.578626128696868	0.503335356456296	NA	NA	0.365998825755058	0.518055407268556	0.589912307468884	0.642188686001672	0.648625592174603	0.591654833236647	0.559838980328965	NA	NA	0.561019534489857	0.588169781701121	NA	NA	p.Phe40Ala	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-0.9	-3.138	2.238	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40C	40	F	C	missense	wt-like	0.785421775320308	0.0716480345822748	6	0.0292501876333094	0.728092461017983	0.842751089622634	0.648180387858982	0.833858641743338	0.786352438778896	0.828661121978451	NA	NA	0.779285131049931	0.836192930512253	0.649922143198434	0.611342039143314	0.637617666617504	0.653809661720465	0.667588133701342	NA	NA	0.646034624676403	0.659719380663924	NA	NA	p.Phe40Cys	1	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-0.9	-5.188	4.288	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40D	40	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe40Asp	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-0.9	-3.437	2.537	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40E	40	F	E	missense	wt-like	0.93601491862352	0.187420151023303	6	0.0765139562537427	0.786050320051512	1.08597951719553	0.77087754267268	0.827026787505112	0.945509270974359	0.801125065551158	NA	NA	0.99723144689049	1.27431939814732	0.674667686487045	0.637476382183327	0.636140539323304	0.701431773735214	0.658468085178617	NA	NA	0.690867287795474	0.758254670480291	NA	NA	p.Phe40Glu	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-0.9	-4.164	3.264	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40G	40	F	G	missense	possibly_wt-like	0.729609147193637	0.0656189518512117	6	0.0267888249152877	0.677104015171524	0.782114279215751	0.70013325342205	0.799391488964027	0.730800858713735	0.798257443041204	NA	NA	0.724589396710516	0.624482442310293	0.632474448548642	0.622407935598684	0.630165462523508	0.637187795527436	0.657518317498387	NA	NA	0.634783434573776	0.612105379106911	NA	NA	p.Phe40Gly	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-0.9	-3.851	2.951	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40H	40	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe40His	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-0.9	-4.88	3.98	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40I	40	F	I	missense	possibly_low	0.71612867171507	0.122299864157527	6	0.0499287104662731	0.618270197406646	0.813987146023493	0.826181829783961	0.580166900882084	0.641714849567529	0.616829428527996	NA	NA	0.882523365144322	0.749355656384524	0.625360737232858	0.649256127305732	0.58276652640397	0.610531925038023	0.597428656507492	NA	NA	0.667271253303553	0.640189549427693	NA	NA	p.Phe40Ile	1	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-0.9	-3.234	2.334	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40K	40	F	K	missense	possibly_low	0.689162995643725	0.367245611336244	6	0.149927393008378	0.395310705051322	0.983015286236129	0.758423172840824	1.22991733960028	0.488148535411154	0.579497554579832	NA	NA	0.913594959348841	0.165396412081417	0.609943906008576	0.634823616729824	0.723250218529481	0.564582579894827	0.585064195287327	NA	NA	0.673662837901674	0.508856252699587	NA	NA	p.Phe40Lys	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-0.9	-4.217	3.317	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40L	40	F	L	missense	possibly_wt-like	0.747633216248923	0.156368000088726	6	0.0638369687194754	0.622515056676541	0.872751375821305	0.491436702690831	0.841787849530401	0.645662175036732	0.743296622508339	NA	NA	0.856016712960413	0.90759923476682	0.6393235677826	0.577955827019975	0.639332054664328	0.611713024039932	0.639315080900872	NA	NA	0.661818700443495	0.675778763979474	NA	NA	p.Phe40Leu	1	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-0.9	-2.94	2.04	0.003433069	NA	NA	NA	NA	3.23e-05	NA	NA
F40M	40	F	M	missense	wt-like	1.00166426114783	0.151337030578143	6	0.0617830840174043	0.880571641619905	1.12275688067575	0.942270169515224	0.729213592449419	1.10176584448977	1.14179646292927	NA	NA	1.00936585936322	1.08557363814008	0.704584434118154	0.673982800862988	0.614992175334316	0.748186084840458	0.771299771247996	NA	NA	0.693363398016193	0.715805470220116	NA	NA	p.Phe40Met	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-0.9	-4.646	3.746	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40N	40	F	N	missense	possibly_wt-like	0.752075106091345	0.278817567370116	6	0.113826795230143	0.52897868696465	0.975171525218041	0.969824889094788	0.770537126891446	0.659163272250259	0.885832012215085	NA	NA	0.985054803937655	0.242038532158839	0.651889366038748	0.679851922237132	0.623926809840365	0.615752754882495	0.68652335394329	NA	NA	0.688362490550702	0.52609317872858	NA	NA	p.Phe40Asn	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-0.9	-4.466	3.566	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40P	40	F	P	missense	possibly_wt-like	0.766717159757399	0.177646506866794	6	0.0725238827352456	0.624572961577311	0.908861357937486	0.622113800171943	1.09774886902443	0.801610327890938	0.772924937588005	NA	NA	0.644052427954473	0.661852595914598	0.634819037725558	0.60578988803166	0.694673839626673	0.658375051056124	0.649128093591583	NA	NA	0.618216571422429	0.620509981859534	NA	NA	p.Phe40Pro	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-0.9	-4.61	3.71	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40Q	40	F	Q	missense	low	0.577301309917636	0.132368905913091	6	0.0540393795495913	0.471386072253547	0.683216547581725	0.452250834754215	0.705430248648417	0.445810343632279	0.656281015673906	NA	NA	0.477913878601559	0.726121538195441	0.596945482624623	0.56960928535378	0.609849936485126	0.551914357716848	0.610495174947387	NA	NA	0.58404102876412	0.634964161923152	NA	NA	p.Phe40Gln	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-0.9	-4.599	3.699	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40R	40	F	R	missense	possibly_low	0.700798071110435	0.205101922737734	6	0.0837325093285313	0.536685368491349	0.86491077372952	0.806034891213915	1.0611282230759	0.480710248819526	0.600446615152782	NA	NA	0.642041809837241	0.614426638563247	0.613823395530869	0.64496485417397	0.686756024963829	0.562356932950376	0.592002605274803	NA	NA	0.617802977072998	0.609843813988739	NA	NA	p.Phe40Arg	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-0.9	-4.478	3.578	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40S	40	F	S	missense	possibly_wt-like	0.737240756711587	0.111497048433996	6	0.0455184794149453	0.648026176427266	0.826455336995907	0.89682376442569	0.831520206501817	0.714942993773777	0.720503235162532	NA	NA	0.674267670034995	0.58538667037071	0.632104353583344	0.66430277248459	0.637112069395941	0.632442884422659	0.631765822744029	NA	NA	0.624432000043155	0.603312682241425	NA	NA	p.Phe40Ser	1	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-0.9	-3.959	3.059	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40T	40	F	T	missense	possibly_low	0.71184105332233	0.223938768187218	6	0.0914226192810149	0.532656012159224	0.891026094485436	0.911415993624714	1.06337534707457	0.662578184304361	0.566146332326044	NA	NA	0.545179350608027	0.522351111996263	0.607326212745897	0.667410899353423	0.687241879619996	0.616774547802834	0.580642218773961	NA	NA	0.59787787768896	0.589135892040437	NA	NA	p.Phe40Thr	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-0.9	-3.959	3.059	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40V	40	F	V	missense	possibly_wt-like	0.748391767587175	0.102590670675455	6	0.0418824659207956	0.66630364279869	0.830479892375661	0.728873724467391	0.900587685645374	0.643503137043598	0.807306942248528	NA	NA	0.631390979312529	0.778688136805633	0.637658044091867	0.628529620576392	0.652045271280391	0.611067007480449	0.660515546680244	NA	NA	0.615612047187301	0.646786467607341	NA	NA	p.Phe40Val	1	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-0.9	-3.674	2.774	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40W	40	F	W	missense	wt-like	1.04902367403987	0.111990146931803	6	0.0457197860337055	0.959414540032932	1.13863280804681	1.02065336969309	1.14595778636422	0.847868141602148	1.15518040738779	NA	NA	1.0768299341982	1.04765240499378	0.706169137751887	0.690678326078162	0.705097174953122	0.672216082922146	0.775732585482289	NA	NA	0.707241100550652	0.70727692886439	NA	NA	p.Phe40Trp	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-0.9	-2.004	1.104	0.003433069	NA	NA	NA	NA	NA	NA	NA
F40X	40	F	X	nonsense	wt-like	0.945547086167152	0.204361149292369	6	0.0834300898358399	0.782027114861964	1.10906705747234	0.805341886730538	0.960315452158983	0.960071873295511	1.26929342516973	NA	NA	0.664101492726104	1.01415838692204	0.682351596044616	0.644817245071507	0.664959117369968	0.705789122831686	0.813527258876929	NA	NA	0.622340765783285	0.699744074719265	NA	NA	p.Phe40Ter	0	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F40Y	40	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe40Tyr	1	24	4.8	20.9	0.726	75.6	104.3	-62.4	-22.5	27.6315789473684	-0.7	0	0	14.95	0	0	0	0	4	9.90292606937652	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-0.9	-3.519	2.619	0.003433069	NA	NA	NA	NA	NA	NA	NA
H41A	41	H	A	missense	wt-like	0.812616022320692	0.0646336891671759	6	0.0263865931088722	0.760899250152589	0.864332794488794	0.794035712075759	0.910041202812718	0.788364362766064	0.753012150094652	NA	NA	0.756395901986189	0.873846804188769	0.648311067108369	0.642409043778274	0.654089232955677	0.65441165956222	0.642532901261061	NA	NA	0.641326194108479	0.668187792479927	NA	NA	p.His41Ala	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-0.881	-3.052	2.171	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41C	41	H	C	missense	wt-like	0.977290806107015	0.270890930276484	6	0.11059075918754	0.760536901076495	1.19404471113754	0.567274841276924	0.7370527691723	1.04697688900927	1.15454193652151	NA	NA	1.0706077368487	1.28729066381339	0.718876785173304	0.594109257246898	0.616687097605438	0.731792407364777	0.775521121458883	NA	NA	0.70596116298183	0.761171927291071	NA	NA	p.His41Cys	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-0.881	-3.421	2.54	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41D	41	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His41Asp	1	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-0.881	-3.77	2.889	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41E	41	H	E	missense	wt-like	0.89999016442759	0.127308417131597	6	0.0519734436556348	0.798124086710024	1.00185624214516	0.744979471537335	1.03540969826011	0.82021993434735	0.806041938830127	NA	NA	0.947672846895108	1.04561709669551	0.672308078401121	0.631960124889884	0.681195377203019	0.663943324506862	0.660096572649315	NA	NA	0.680672832295381	0.706819185021343	NA	NA	p.His41Glu	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-0.881	-3.577	2.696	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41F	41	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His41Phe	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-0.881	-4.267	3.386	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41G	41	H	G	missense	wt-like	0.848618879841971	0.110695378871254	6	0.045191199186439	0.760045757018375	0.937192002665567	0.942399908941143	0.981746657199905	0.854661582044287	0.797895167852255	NA	NA	0.845642810634625	0.669367152379611	0.664638766114582	0.67401043520111	0.669592796135599	0.674248782224076	0.657398330552888	NA	NA	0.659684736093566	0.622200016709787	NA	NA	p.His41Gly	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-0.881	-3.63	2.749	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41I	41	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His41Ile	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-0.881	-4.275	3.394	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41K	41	H	K	missense	possibly_low	0.350532613730106	0.486445467224288	6	0.198590530398211	-0.0386976735210934	0.739762900981305	0.849718200014051	1.05680144300085	0.128140538499303	0.227198711323972	NA	NA	-0.100639750053376	-0.058023460404162	0.466705532821324	0.65426934521159	0.68582052418732	0.456862786037116	0.468381454115689	NA	NA	0.465029611526959	0.458608793318888	NA	NA	p.His41Lys	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-0.881	-3.737	2.856	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41L	41	H	L	missense	possibly_low	0.701111872991768	0.095840901118685	6	0.0391268840382193	0.624424589449583	0.777799156533953	0.805311032986103	0.817475593198172	0.626734475420349	0.718640516301271	NA	NA	0.653085293248903	0.58542432679581	0.625611780346892	0.644810673261897	0.63407545870082	0.606049572343394	0.631148883043758	NA	NA	0.620074677650026	0.60332115122706	NA	NA	p.His41Leu	1	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-0.881	-3.833	2.952	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41M	41	H	M	missense	wt-like	0.979663038406992	0.0969939748082667	6	0.0395976244007699	0.902053120708139	1.05727295610585	1.09185278548307	1.07211296762926	0.847914369084809	0.889363288895509	NA	NA	0.977359726108062	0.999375093241245	0.688411991238318	0.705843714055815	0.68913105602184	0.672229914878507	0.687692926454796	NA	NA	0.686779573993114	0.69641929013106	NA	NA	p.His41Met	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-0.881	-4.983	4.102	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41N	41	H	N	missense	wt-like	0.780998185965554	0.0659356602698534	6	0.0269181205857737	0.728239639085931	0.833756732845177	0.852653234086431	0.800249870080173	0.832928710745041	0.797226760005625	NA	NA	0.683839041547692	0.719091499328361	0.644138799827471	0.65489450385849	0.630351054623584	0.667745981074178	0.657176951285659	NA	NA	0.626400879732455	0.633383095796453	NA	NA	p.His41Asn	1	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-0.881	-2.474	1.593	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41P	41	H	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His41Pro	1	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-0.881	-4.196	3.315	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41Q	41	H	Q	missense	possibly_low	0.704931311090794	0.122567455963819	6	0.050037954363734	0.606858722677817	0.803003899503772	0.707842722743379	0.909901619908627	0.681566992616834	0.652413835958683	NA	NA	0.536275038611335	0.741587656705909	0.623253163609207	0.624050043080362	0.654059053488984	0.622456284138052	0.609214350049964	NA	NA	0.596046215527041	0.638442514824288	NA	NA	p.His41Gln	1	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-0.881	-3.339	2.458	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41R	41	H	R	missense	possibly_wt-like	0.723267136702566	0.069305153915277	6	0.0282937106062467	0.667812482925324	0.778721790479809	0.792741140898092	0.801921549977528	0.651409013364714	0.760524546100687	NA	NA	0.664646724901515	0.668359844972863	0.626582707150413	0.642133301709942	0.630712491492323	0.613432564287187	0.645021035910184	NA	NA	0.622452922808503	0.621973471785912	NA	NA	p.His41Arg	1	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-0.881	-3.233	2.352	0.00234936	NA	NA	NA	NA	4.06e-06	NA	NA
H41S	41	H	S	missense	wt-like	0.940147405232779	0.118792852039945	6	0.0484969787646343	0.845095073495092	1.03519973697047	0.925000602318018	1.00589940942232	0.89159969838939	0.830984401673127	NA	NA	1.14535226257942	0.842048057014402	0.672559654863664	0.670304404294057	0.674814905433271	0.685301220815213	0.668357612933172	NA	NA	0.721336491209593	0.66103620726405	NA	NA	p.His41Ser	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-0.881	-3.616	2.735	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41T	41	H	T	missense	possibly_wt-like	0.868904100607015	0.272291693908765	6	0.111162618545763	0.651029371830156	1.08677882938387	0.636178717215515	0.701377070893448	0.703842166128953	0.762465766458641	NA	NA	1.3149780576051	1.09458282534043	0.637392662928167	0.608785698060052	0.608973591750397	0.629121350246175	0.645663975610159	NA	NA	0.756229377998532	0.717831649730768	NA	NA	p.His41Thr	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-0.881	-3.015	2.134	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41V	41	H	V	missense	wt-like	0.941705216904646	0.127549816632856	6	0.0520719945893427	0.83964598290637	1.04376445090292	0.731374003747328	0.891222196137662	1.07152250435367	0.899285519068995	NA	NA	1.00757608654949	1.04925099157074	0.691987220089335	0.629062176987312	0.650020342221163	0.739136823732441	0.690979207512317	NA	NA	0.692995232666353	0.707636453347142	NA	NA	p.His41Val	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-0.881	-3.982	3.101	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41W	41	H	W	missense	wt-like	1.09289338189471	0.119869174713467	6	0.0489363856560869	0.996979828475219	1.1888069353142	0.900478802239739	1.13053681604182	1.07347921285973	1.05910566579565	NA	NA	1.12526360654605	1.26849618788528	0.728463226499573	0.665081291042755	0.701762979671433	0.739722300273852	0.743912259015346	NA	NA	0.717204152725295	0.756945021889717	NA	NA	p.His41Trp	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-0.881	-5.483	4.602	0.00234936	NA	NA	NA	NA	NA	NA	NA
H41X	41	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His41Ter	0	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H41Y	41	H	Y	missense	possibly_wt-like	0.819977248603991	0.295234029646652	6	0.120528787890003	0.583745165239317	1.05620933196866	0.933308293720087	1.22396351755501	0.964740259101892	0.826296484425497	NA	NA	0.573503125737125	0.398051811084333	0.669439444464861	0.672073932343031	0.721962932129447	0.70718597390451	0.666804956586691	NA	NA	0.603704221959684	0.5611807956377	NA	NA	p.His41Tyr	1	21.8	6.6	23.4	0.465	61.8	-154.2	-72.4	131.3	7.87037037037037	-3	0	0	14.36	0	0	0	0	5	10.413615179138	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-0.881	-3.785	2.904	0.00234936	NA	NA	NA	NA	NA	NA	NA
Q42A	42	Q	A	missense	wt-like	0.906394151934428	0.167403937628293	6	0.0683423713536698	0.772445565463174	1.04034273840568	0.892266620119844	1.23289864299193	0.814267860460006	0.7583134508682	NA	NA	0.882479258463728	0.858139078702859	0.66399360408324	0.663332106353394	0.723894811411375	0.662162374701107	0.644288712606668	NA	NA	0.667262180335539	0.664655101813087	NA	NA	p.Gln42Ala	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-1.883	-2.889	1.006	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42C	42	Q	C	missense	possibly_wt-like	0.838872925301208	0.218954622357378	6	0.0893878502665603	0.663675958123291	1.01406989247913	0.923602250906689	0.99840019322485	0.965744540887694	1.01357260799716	NA	NA	0.641778487815935	0.490139470974923	0.671600021896273	0.670006557163619	0.673193486628928	0.70748647008201	0.72883153394468	NA	NA	0.617748810397009	0.581891446388406	NA	NA	p.Gln42Cys	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-1.883	-4.311	2.428	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42D	42	Q	D	missense	wt-like	1.00288280903373	0.202340445809962	4	0.101170222904981	0.804592815832082	1.20117280223539	NA	NA	1.14762293644705	0.980363440251213	NA	NA	1.15845097579246	0.725093883644212	0.720931745984912	NA	NA	0.761907214745697	0.717832528983965	NA	NA	0.724030962985859	0.634733040896424	NA	NA	p.Gln42Asp	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-1.883	-3.285	1.402	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42E	42	Q	E	missense	wt-like	1.23633866691469	0.438471936095272	4	0.219235968047636	0.806644065425552	1.66603326840383	NA	NA	1.55284536988573	1.02822543431702	NA	NA	0.719859153868089	1.64442470958793	0.787588254272968	NA	NA	0.88315584636213	0.733684606765224	NA	NA	0.63381039961786	0.841491901780713	ND	*17	p.Gln42Glu	1	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-1.883	-2.25	0.367	0.007723284	NA	NA	1	0.1	NA	NA	NA
Q42F	42	Q	F	missense	possibly_wt-like	0.874082394746043	0.278518875809445	6	0.113704854911123	0.651224974252889	1.0969398152392	0.975846519671997	1.31780638077352	0.901844072597221	0.825066534012067	NA	NA	0.753445176579068	0.470485684842385	0.673766057194675	0.681134522142598	0.742252863646189	0.688366491274022	0.666397592246752	NA	NA	0.640719214919021	0.577471280852614	NA	NA	p.Gln42Phe	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-1.883	-3.97	2.087	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42G	42	Q	G	missense	possibly_wt-like	0.783923200502012	0.109361227886685	6	0.0446465343277679	0.696417601185056	0.871428799818968	0.815377126853469	0.990383014958365	0.739442103916491	0.688538660756485	NA	NA	0.747164803249868	0.722633493277395	0.639600347996115	0.64695473887289	0.67146007832908	0.639773385736264	0.621179031917203	NA	NA	0.639427310255966	0.634179695468187	NA	NA	p.Gln42Gly	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-1.883	-3.118	1.235	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42H	42	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln42His	1	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-1.883	-5.018	3.135	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42I	42	Q	I	missense	wt-like	1.33205659821472	0.264927346793111	6	0.108156136425414	1.12007446611391	1.54403873031554	1.24026542409488	0.921914255344247	1.45356074083889	1.4521768896887	NA	NA	1.6980263044784	1.22639597484324	0.791250483954519	0.737455423511049	0.656656326653558	0.853448395789069	0.874098970545993	NA	NA	0.835024346127219	0.747476621781819	NA	NA	p.Gln42Ile	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-1.883	-3.533	1.65	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42K	42	Q	K	missense	wt-like	1.17712049941551	0.260890043355318	6	0.106507914198852	0.968368823517283	1.38587217531375	1.36939204297921	1.20015211546035	0.911344285096447	1.0086220729648	NA	NA	1.58645311859635	0.986759361395929	0.72200326215892	0.764959234488934	0.716814626746934	0.691209097384996	0.727191897570905	NA	NA	0.812073175622318	0.693581993401798	NA	NA	p.Gln42Lys	1	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-1.883	-2.503	0.62	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42L	42	Q	L	missense	wt-like	1.1269941317479	0.114696265251252	6	0.0468245542114136	1.03521969190138	1.21876857159441	1.0622493650119	1.05138638790778	1.04089699258055	1.06890794690373	NA	NA	1.3172240534819	1.22130004460154	0.738151875339579	0.699538221911959	0.684649725543401	0.729973211136926	0.747158812477897	NA	NA	0.75669139074751	0.746330539542232	NA	NA	p.Gln42Leu	1	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-1.883	-2.066	0.183	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42M	42	Q	M	missense	wt-like	1.19836314707626	0.176825427444096	6	0.0721886784645941	1.05687593719412	1.33985035695841	1.00786983461518	0.94221648513219	1.27322786535655	1.35088421565714	NA	NA	1.28029779915004	1.33568268254649	0.760575418322994	0.687955448832171	0.661045907681957	0.799490093919785	0.840550444648555	NA	NA	0.749095472852204	0.772055363793785	NA	NA	p.Gln42Met	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-1.883	-3.514	1.631	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42N	42	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln42Asn	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-1.883	-3.248	1.365	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42P	42	Q	P	missense	possibly_wt-like	0.754482517825736	0.256950307734991	6	0.104899523866974	0.548883229051068	0.960081806600404	0.78488889830356	0.99241014392825	0.626299865005727	0.976671556086406	NA	NA	0.838961676168724	0.307662967461748	0.649385588263883	0.640460783696704	0.671898367470779	0.605919530386901	0.716609762651676	NA	NA	0.658310392831062	0.540852211175334	NA	NA	p.Gln42Pro	1	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-1.883	-4.376	2.493	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42R	42	Q	R	missense	wt-like	0.908267629556567	0.0930940576680943	6	0.0380054898953438	0.833778238146893	0.982757020966242	0.899458365605962	1.02126748619651	0.942583214460772	0.983735465850875	NA	NA	0.820261588626673	0.782299656598611	0.671500801901175	0.664863939295046	0.678137664507303	0.700556253726872	0.718949356920819	NA	NA	0.654463689931605	0.647598703744088	NA	NA	p.Gln42Arg	1	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-1.883	-2.432	0.549	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42S	42	Q	S	missense	wt-like	0.878959687257776	0.107383865639959	6	0.0438392795709146	0.793036278190601	0.964883096324951	1.07493736089426	0.915657795641509	0.851668147846291	0.765288591854095	NA	NA	0.837032269871564	0.829173957438939	0.658027153707857	0.702240749426825	0.655303606430069	0.673353101801694	0.646598906312589	NA	NA	0.657913504165123	0.658140803250591	NA	NA	p.Gln42Ser	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-1.883	-2.999	1.116	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42T	42	Q	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln42Thr	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-1.883	-3.564	1.681	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42V	42	Q	V	missense	wt-like	1.00132770152572	0.0738679778754739	6	0.0301564756876847	0.942222095277199	1.06043330777424	0.937885509142964	1.06789925229441	0.962705407077321	1.00778996093929	NA	NA	1.10768767799645	0.923998401703874	0.697398558411431	0.673048873597465	0.688220001172885	0.706577115649977	0.726916298845684	NA	NA	0.713588695035037	0.679466960850145	NA	NA	p.Gln42Val	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-1.883	-3.14	1.257	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42W	42	Q	W	missense	wt-like	0.848673972485928	0.120055471472302	6	0.0490124409894003	0.752611353352308	0.944736591619547	0.664304265346497	0.804543106983338	0.788459262265596	0.952849831071759	NA	NA	0.892875823446848	0.989011545801528	0.661920430712667	0.614776405213446	0.631279302971543	0.654440054916252	0.708719915076652	NA	NA	0.669400806509082	0.694088513001775	NA	NA	p.Gln42Trp	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-1.883	-5.783	3.9	0.007723284	NA	NA	NA	NA	NA	NA	NA
Q42X	42	Q	X	nonsense	low	0.478575297997573	0.24828649524099	8	0.0877825322309727	0.306524696353141	0.650625899642006	0.46540875241621	0.747395131335325	0.409385687480946	0.852950082896671	0.267896732949257	0.0688386272635176	0.501369027948674	0.515358341689987	0.579987556648878	0.572411905629637	0.618923238030102	0.541015554119104	0.675632731617011	0.545156797567541	0.493238582434419	0.588865872006049	0.587563207668119	NA	NA	p.Gln42Ter	1	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q42Y	42	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln42Tyr	0	23.6	7.9	26.6	0.876	6	-168.4	-110.5	99.7	20.0934579439252	-2	0	0	14.88	0	0	0	0	5	13.411505210388	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-1.883	-4.627	2.744	0.007723284	NA	NA	NA	NA	NA	NA	NA
E43A	43	E	A	missense	wt-like	1.01343661683682	0.108938185991899	6	0.044473828197427	0.926269515315238	1.1006037183584	0.925543201913248	0.89566541596441	1.13836775644302	1.14464324726861	NA	NA	1.03089426960717	0.945505809824442	0.691047954978463	0.670419977340364	0.650981018642434	0.759137926033496	0.772242637245422	NA	NA	0.697791901247523	0.684304008709404	NA	NA	p.Glu43Ala	1	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.321	-2.373	0.052	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43C	43	E	C	missense	wt-like	0.992576802793308	0.212571076159091	6	0.0867817784440127	0.822487642528708	1.16266596305791	0.811089605326674	0.650172254253793	1.15933464367366	1.05756258876364	NA	NA	1.11576808767003	1.16153363707204	0.724069931252032	0.646041502061956	0.59790250773491	0.765411533258048	0.743401185926744	NA	NA	0.715250876308267	0.732888986195796	NA	NA	p.Glu43Cys	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.321	-4.477	2.156	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43D	43	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Asp	1	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.321	-2.326	0.005	0.008566043	NA	NA	NA	NA	4.06e-06	NA	NA
E43E	43	E	E	synonymous	wt-like	1.16152788227747	0.25080973618126	6	0.102392646027692	0.960841983781431	1.3622137807735	1.25091567748421	1.22375408110344	0.83149629462192	1.09713419373816	NA	NA	1.56588165086389	0.999985395853187	0.730820781942631	0.73972391438162	0.721917649503643	0.667317380679674	0.756507454736245	NA	NA	0.807841520321527	0.696556548090087	NA	NA	p.Glu43=	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43F	43	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Phe	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.321	-4.184	1.863	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43G	43	E	G	missense	wt-like	0.946497818574296	0.04037947503767	6	0.016484851653957	0.914188103042055	0.978807534106537	0.939595446151152	0.956976797389161	1.00069718481136	0.970483561146567	NA	NA	0.881745617316923	0.929488304630609	0.677057368102676	0.673413088076738	0.664237260914246	0.717944825536714	0.714560274764449	NA	NA	0.66711126662884	0.680701648128614	NA	NA	p.Glu43Gly	1	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.321	-2.556	0.235	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43H	43	E	H	missense	low	0.225351481778234	0.403352110056857	4	0.201676055028429	-0.169926322621604	0.620629286178072	NA	NA	0.122310085129519	-0.260870898145482	NA	NA	0.336362643143771	0.703604096985127	0.505020724127611	NA	NA	0.455118226914881	0.306730909398722	NA	NA	0.554923221340342	0.629899956129884	NA	NA	p.Glu43His	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.321	-3.694	1.373	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43I	43	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Ile	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.321	-4.521	2.2	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43K	43	E	K	missense	wt-like	0.854183174349743	0.114129335882129	6	0.0465931062656552	0.762862364141211	0.945503984558274	0.789546310961384	0.778254440601025	0.752957875478049	0.911881869774907	NA	NA	0.835180276258347	1.05727827302474	0.650675023522505	0.641452806863527	0.625595383893737	0.643817507363916	0.695151167645771	NA	NA	0.657532539681094	0.709441800804869	NA	NA	p.Glu43Lys	1	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.321	-2.866	0.545	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43L	43	E	L	missense	wt-like	0.92291628680238	0.173277002616404	6	0.0707400400948494	0.784268355951556	1.0615642176532	0.990089987820458	1.20193083205788	0.880996076400021	0.974318941117247	NA	NA	0.737570323674958	0.752591559743722	0.68314841068354	0.684168363336687	0.717199206210025	0.682128458030392	0.715830567463335	NA	NA	0.637453677121009	0.640917308873584	NA	NA	p.Glu43Leu	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.321	-3.45	1.129	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43M	43	E	M	missense	wt-like	1.03096696578181	0.0834079066342331	6	0.0340511352945952	0.964227966971704	1.09770596459192	0.957870576251001	1.01671517665108	0.927012312001077	1.06789806127223	NA	NA	1.15890914592485	1.05739652259063	0.7026828007042	0.677305668306944	0.677153401604916	0.695897206101473	0.74682433444594	NA	NA	0.724125210907037	0.709468395306927	NA	NA	p.Glu43Met	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.321	-5.243	2.922	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43N	43	E	N	missense	low	0.403241850043691	0.322532598343683	4	0.161266299171841	0.0871657117468204	0.719317988340562	0.837735393434802	NA	NA	0.0738343716594134	NA	NA	0.282631334886585	0.418766300193964	0.554854966708375	0.651717022150801	NA	NA	0.417586590911887	NA	NA	0.543870418576731	0.565839514840018	NA	NA	p.Glu43Asn	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.321	-2.814	0.493	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43P	43	E	P	missense	wt-like	1.14058851220376	0.132146336202506	6	0.0539485158457361	1.03485136412673	1.24632566028079	0.980105137111069	1.004452695532	1.30569608242758	1.26282205189237	NA	NA	1.16498618700529	1.12546891925426	0.725076633487408	0.682041602418403	0.674502108863004	0.809205071586449	0.811383914986928	NA	NA	0.725375289094731	0.724777977880086	NA	NA	p.Glu43Pro	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.321	-2.299	-0.022	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43Q	43	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Gln	1	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.321	-2.809	0.488	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43R	43	E	R	missense	wt-like	0.969920031271506	0.0554336557391197	6	0.0226306951896579	0.925564683754672	1.01427537878834	0.931933785856122	1.04530018486959	0.943442960865149	0.895900162095182	NA	NA	0.995625352924457	1.00731774101854	0.690197435144694	0.671781163858851	0.683333816814632	0.700813502749793	0.689857964172718	NA	NA	0.690536906116669	0.698205603349865	NA	NA	p.Glu43Arg	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.321	-3.101	0.78	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43S	43	E	S	missense	possibly_wt-like	0.824459629046527	0.174889001633996	6	0.0713981359380106	0.684521854044731	0.964397404048323	0.9162635177495	0.879338469238168	0.595501760884333	0.859732879459033	NA	NA	1.05619202764814	0.63972911929999	0.65794717831407	0.668443416028844	0.647450940599295	0.596704275571389	0.677879220105	NA	NA	0.702995778447944	0.615534379285845	NA	NA	p.Glu43Ser	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.321	-2.323	0.002	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43T	43	E	T	missense	possibly_low	0.565525732585221	0.36959608321149	6	0.15088696913323	0.269792707347683	0.861258757822759	0.372759752087109	0.950220729962534	0.487373560898102	1.02911677215942	NA	NA	0.0421546492151882	0.511528931188977	0.575526331741432	0.552677782531253	0.662776519620691	0.564350695893619	0.733979821310351	NA	NA	0.494403144054946	0.586701967589245	NA	NA	p.Glu43Thr	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.321	-2.703	0.382	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43V	43	E	V	missense	wt-like	0.957126973757977	0.107404909559675	6	0.043847870715163	0.871186726357489	1.04306722115847	1.10875530899791	1.01417679988533	0.891322639911805	1.00114747468744	NA	NA	0.80162951372236	0.925730105343016	0.682537372159432	0.709443930771921	0.676604574672592	0.685218320762026	0.724716281675889	NA	NA	0.650630977576855	0.679856423556838	NA	NA	p.Glu43Val	1	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.321	-4.141	1.82	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43W	43	E	W	missense	possibly_wt-like	0.74083449660988	0.162052894504274	6	0.0661578171460907	0.611167557707756	0.870501435512005	0.936639985969311	0.91225085190849	0.761681179930608	0.669453094609777	NA	NA	0.519613712301403	0.645368154939694	0.631615128831595	0.672783578693651	0.654566985096773	0.646427650931415	0.614857818500124	NA	NA	0.592618896158557	0.616802606731775	NA	NA	p.Glu43Trp	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.321	-5.964	3.643	0.008566043	NA	NA	NA	NA	NA	NA	NA
E43X	43	E	X	nonsense	low	0.374696437341276	0.229679348540592	6	0.0937662013965505	0.190918059636907	0.558474815045644	0.579904986517301	0.730729897802262	0.18778618715123	0.305110814291274	NA	NA	0.156444929112695	0.288201809172892	0.527194301256326	0.596799462646187	0.615320018397843	0.474709658974409	0.494186244334853	NA	NA	0.517913234586496	0.536475367926156	NA	NA	p.Glu43Ter	1	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E43Y	43	E	Y	missense	possibly_wt-like	0.771824528992293	0.305121824519736	6	0.124565463243397	0.527680707317686	1.0159683506669	0.628211490052273	1.06867448041804	1.00927332424014	0.962640516484422	NA	NA	0.263258096361092	0.698889266397785	0.658613599191433	0.607088688475127	0.688387614617305	0.720510935121187	0.711962627999978	NA	NA	0.53988524510413	0.628839583765561	NA	NA	p.Glu43Tyr	0	21.1	8.1	29.5	0.788	90.3	44.7	-57.3	-34.6	62.6168224299065	-1.2	0	0	18.97	0	0	0	0	4	15.7724149073078	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.321	-4.807	2.486	0.008566043	NA	NA	NA	NA	NA	NA	NA
Q44A	44	Q	A	missense	wt-like	1.15094226526307	0.0965078710867822	6	0.0393991733874857	1.07372130440295	1.22816322612319	1.00144094078121	1.11375860342128	1.11007794685732	1.19907679070986	NA	NA	1.20354225262771	1.27775705718107	0.741989829008863	0.686586102354007	0.698135332630747	0.750673190574879	0.790271237628303	NA	NA	0.733306467442848	0.759027805075442	NA	NA	p.Gln44Ala	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.274	-2.507	0.233	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44C	44	Q	C	missense	wt-like	1.06431550042387	0.126330830323331	6	0.0515743455123803	0.963231640693378	1.16539936015436	0.976175340407691	1.24084321054678	1.02554801174488	0.977954351401072	NA	NA	1.20764714457696	0.957724943865828	0.72120759760923	0.681204560554803	0.725612520420772	0.725380565790914	0.717034629427547	NA	NA	0.734150864546745	0.687052110006667	NA	NA	p.Gln44Cys	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.274	-5.592	3.318	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44D	44	Q	D	missense	wt-like	1.07038214277544	0.179763499531621	6	0.0733881413715857	0.926544028794793	1.21422025675608	0.84735087169462	1.11163882170089	0.937020091042323	1.02184864238184	NA	NA	1.36144311147814	1.1429913183548	0.713805237530246	0.653765107191709	0.697677010873907	0.698891683736814	0.731572588582019	NA	NA	0.765787475363313	0.728718791323679	NA	NA	p.Gln44Asp	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.274	-2.322	0.048	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44E	44	Q	E	missense	wt-like	1.09476868270159	0.342518741189115	6	0.13983269054229	0.820701645377361	1.36883572002581	0.475667576364893	1.03533164999058	1.08568133723026	1.4096421618747	NA	NA	1.15649200163874	1.40579736911034	0.733500675507576	0.574597022510864	0.681178502248554	0.743373358953367	0.860011303977296	NA	NA	0.723627992061784	0.787824260382585	NA	NA	p.Gln44Glu	1	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.274	-1.981	-0.293	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44F	44	Q	F	missense	wt-like	1.1507735456513	0.205255979393173	5	0.091793264542286	0.970862053125061	1.33068503817754	0.864134620902211	NA	1.09578995320081	1.21544225757638	NA	NA	1.43208120872982	1.14641968784728	0.746398008510807	0.657340025126479	NA	0.746398008510807	0.795691543630136	NA	NA	0.780318090415203	0.729489836687275	NA	NA	p.Gln44Phe	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.274	-3.69	1.416	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44G	44	Q	G	missense	wt-like	0.96803420482178	0.0899900401896396	6	0.0367382800661947	0.896028499038092	1.04003991060547	0.929154097370794	0.972032821249095	1.05208152854002	1.09318278130908	NA	NA	0.903729894278691	0.858024106183001	0.671411318794089	0.671189093630896	0.66749255047549	0.733319792097025	0.755198731637799	NA	NA	0.671633543957282	0.664629244323522	NA	NA	p.Gln44Gly	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.274	-3.283	1.009	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44H	44	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln44His	1	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.274	-3.057	0.783	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44I	44	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln44Ile	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.274	-4.415	2.141	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44K	44	Q	K	missense	possibly_low	0.704919465706883	0.296590054892765	6	0.121082382878554	0.467602356102627	0.942236575311139	0.939512344149145	1.10602940862085	0.742662833135306	0.696169326479439	NA	NA	0.399900477833919	0.345242404022639	0.632221707096771	0.673395387452538	0.696464189745698	0.64073707623897	0.623706337954572	NA	NA	0.567993276353626	0.549303881974066	NA	NA	p.Gln44Lys	1	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.274	-2.475	0.201	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44L	44	Q	L	missense	possibly_wt-like	0.79233825845343	0.172672288206222	6	0.0704931664706737	0.654174191014723	0.930502325892137	1.05152043250935	0.971700291386062	0.682066345849241	0.687037109034486	NA	NA	0.652338085817029	0.709367286124407	0.62690090199912	0.697252972487061	0.667420653605374	0.62260569811696	0.620681712172084	NA	NA	0.619920973289647	0.631196105881281	NA	NA	p.Gln44Leu	1	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.274	-3.627	1.353	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44M	44	Q	M	missense	wt-like	0.953054268854066	0.280394466721288	6	0.114470561694492	0.728696090642791	1.17741244706534	0.418136699812125	1.00875592376099	1.1734505023798	1.18166525720188	NA	NA	0.932297504288808	1.0040197256808	0.687486960564297	0.562343016576451	0.6754325174532	0.769635209962435	0.784504470303898	NA	NA	0.677510046300352	0.697463874828241	NA	NA	p.Gln44Met	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.274	-4.3	2.026	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44N	44	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln44Asn	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.274	-3.051	0.777	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44P	44	Q	P	missense	wt-like	0.85746956519949	0.0934838970244888	6	0.0381646411461474	0.782668243070146	0.932270887328835	0.839140094677432	0.802859370284462	0.785920032841547	0.822834725599443	NA	NA	1.0419429479559	0.852120219838157	0.658490865469694	0.652016221787495	0.630915259280411	0.653680279376646	0.665658408657762	NA	NA	0.700064670449467	0.663301451562741	NA	NA	p.Gln44Pro	1	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.274	-4.377	2.103	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44Q	44	Q	Q	synonymous	wt-like	1.14244337074971	0.120307591762898	2	0.0850703139637682	0.975708619227212	1.30917812227221	1.22751368471348	1.05737305678594	NA	NA	NA	NA	NA	NA	0.710341716262301	0.734739318709302	0.685944113815299	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln44=	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44R	44	Q	R	missense	wt-like	0.918499178407049	0.109750207755921	6	0.0448053346944084	0.830682336090745	1.00631602072335	0.881888466781097	1.04214549620203	0.931986665705575	1.03913033018029	NA	NA	0.76097316220788	0.854870949365418	0.67328591534625	0.661121572458875	0.68265173599542	0.697385607359835	0.737296350504596	NA	NA	0.642267759763012	0.663920094697081	NA	NA	p.Gln44Arg	1	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.274	-2.64	0.366	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44S	44	Q	S	missense	wt-like	1.02161824687247	0.120141500644977	6	0.0490475622520748	0.925486791328913	1.11774970241602	0.81076909425192	0.951133138216111	1.05097714827213	1.1023621335507	NA	NA	1.12597906481056	1.08848890213337	0.716906221759886	0.645973233597308	0.662973793023754	0.732989344951912	0.758238968647476	NA	NA	0.717351326120838	0.716461117398935	NA	NA	p.Gln44Ser	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.274	-2.954	0.68	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44T	44	Q	T	missense	wt-like	0.933433538386676	0.0462766535547227	6	0.018892364702104	0.896405183987756	0.970461892785596	0.941524870668104	0.947350896492053	0.911519344932084	0.990236406619316	NA	NA	0.85437345387333	0.955596257735169	0.680198709238273	0.673824053125377	0.662156027847705	0.691261477914232	0.721102493678368	NA	NA	0.661480673710699	0.686573365351169	NA	NA	p.Gln44Thr	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.274	-2.953	0.679	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44V	44	Q	V	missense	wt-like	1.17620286138042	0.152031724628369	6	0.0620666916758046	1.05455438105629	1.29785134170455	1.15129450997768	1.09289392303157	1.09845107797748	1.11593936098831	NA	NA	1.11490771704192	1.48373057926556	0.732849492609965	0.718504728251221	0.693624143162453	0.747194256968709	0.762735798952933	NA	NA	0.715073893704184	0.805351554477403	NA	NA	p.Gln44Val	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.274	-3.187	0.913	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44W	44	Q	W	missense	possibly_wt-like	0.786681217451854	0.14224672395131	6	0.0580719818772074	0.672862224461665	0.900500210442044	0.862466159729531	0.889426084427256	0.882323030927515	0.780392748188471	NA	NA	0.793812660681741	0.511666620756613	0.650616731555829	0.656984644949147	0.649632001729935	0.68252550273325	0.651601461381723	NA	NA	0.649023011240421	0.586732934176416	NA	NA	p.Gln44Trp	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.274	-5.832	3.558	0.008311559	NA	NA	NA	NA	NA	NA	NA
Q44X	44	Q	X	nonsense	low	0.477945179660617	0.259194440446022	6	0.105815687209826	0.270550243730002	0.685340115591231	0.602594658931925	0.915215725159762	0.447114935404347	0.39649610130413	NA	NA	0.151900003804328	0.354349653359208	0.551828413475898	0.601632334958912	0.655208025588942	0.552304711147774	0.524453405285117	NA	NA	0.516978320387715	0.551352115804021	NA	NA	p.Gln44Ter	1	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q44Y	44	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln44Tyr	0	23.5	10	31.7	0.489	115.9	-123	-90.4	-5.3	73.3644859813084	-0.5	0	0	19.21	0	0	0	0	4	18.078996834828	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.274	-3.505	1.231	0.008311559	NA	NA	NA	NA	NA	NA	NA
G45A	45	G	A	missense	wt-like	0.884119682384034	0.120102951839917	6	0.0490318247683096	0.788019071741868	0.9802202930262	0.672951272233961	1.00831538446789	0.906181603815531	0.823884211571996	NA	NA	0.95566755746128	0.937718064753545	0.678827326250212	0.616618207043403	0.67533726767308	0.689664345690301	0.66600600247603	NA	NA	0.682317384827344	0.682552533338106	NA	NA	p.Gly45Ala	1	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-2.213	-2.247	0.034	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45C	45	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly45Cys	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-2.213	-5.278	3.065	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45D	45	G	D	missense	possibly_low	0.509619190199782	0.363494028574728	6	0.148395815759455	0.218768735854809	0.800469644544756	0.906676381162528	0.731493869598071	0.307931380110596	0.83895880587817	NA	NA	0.0224840168846826	0.250170687564646	0.571703655292352	0.666401367729388	0.615485198091706	0.510658903240076	0.670998766486945	NA	NA	0.490356795167554	0.527922112492998	NA	NA	p.Gly45Asp	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-2.213	-4.19	1.977	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45E	45	G	E	missense	possibly_wt-like	0.749273117572537	0.303721372555281	6	0.123993731123031	0.506249870262652	0.992296364882422	1.18373648754449	1.08453259864477	0.557399374405891	0.483888416035423	NA	NA	0.548238874847442	0.637842953957212	0.606808707632065	0.725414829564611	0.691816326420945	0.585303469888871	0.553398078352852	NA	NA	0.598507237350312	0.615110177913818	NA	NA	p.Gly45Glu	1	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-2.213	-3.434	1.221	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45F	45	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly45Phe	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-2.213	-3.62	1.407	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45G	45	G	G	synonymous	wt-like	0.896397228398654	0.0844279427513797	6	0.0344675632956317	0.828842045704361	0.963952411092947	0.907303552684091	1.03608519211423	0.901518809956648	0.860913234161667	NA	NA	0.775062355336345	0.897500226138941	0.675888820086619	0.666534954491969	0.681341426924544	0.688269167812064	0.678270158153463	NA	NA	0.64516597828399	0.673507482019776	NA	NA	p.Gly45=	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45H	45	G	H	missense	wt-like	0.908881487149046	0.111704146728988	6	0.0456030269398339	0.819501196760962	0.998261777537131	0.779794068435023	1.07824689702636	0.851747218169841	0.857021789749239	NA	NA	1.00929317532691	0.8771857741869	0.675179028761574	0.639375591202086	0.690457283751124	0.673376760828789	0.676981296694359	NA	NA	0.693348446541095	0.668938731765175	NA	NA	p.Gly45His	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-2.213	-5.267	3.054	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45I	45	G	I	missense	wt-like	1.0874422870689	0.173023287071607	6	0.0706364611574216	0.948997367204988	1.22588720693281	0.922750505710914	0.960926159960193	1.07421220614541	1.30546779195037	NA	NA	1.29664832076938	0.964648737877113	0.714275452185166	0.669825136484689	0.66509115958435	0.73994162286199	0.825508349240737	NA	NA	0.75245885811868	0.688609281508341	NA	NA	p.Gly45Ile	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-2.213	-2.119	-0.094	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45K	45	G	K	missense	wt-like	0.926746888006718	0.052176754736376	3	0.0301242633924877	0.867704416696644	0.985789359316793	0.875330728423453	NA	NA	NA	NA	NA	0.979652350670625	0.925257584926077	0.679750153017013	0.659724782255667	NA	NA	NA	NA	NA	0.687251178499368	0.679750153017013	NA	NA	p.Gly45Lys	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-2.213	-4.105	1.892	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45L	45	G	L	missense	wt-like	1.12508842076194	0.0967217196118156	6	0.0394864766822488	1.04769634858835	1.20248049293553	1.05609869085446	1.2123257857762	1.1470810570144	0.981218710181996	NA	NA	1.11423810016763	1.23956818057697	0.718781257622508	0.698228135882647	0.719446717547924	0.761745076289659	0.718115797697093	NA	NA	0.714936150115228	0.750439070310665	NA	NA	p.Gly45Leu	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-2.213	-3.206	0.993	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45M	45	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly45Met	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-2.213	-4.853	2.64	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45N	45	G	N	missense	possibly_low	0.656378439687119	0.3694484757889	6	0.150826708655298	0.360763522816019	0.951993356558219	1.21021806927102	0.95714440008635	0.408459311386782	0.704064447745081	NA	NA	0.390113748469955	0.268270661163522	0.596150664576647	0.731055373896176	0.664273498589988	0.540738368493356	0.62632123269179	NA	NA	0.565980096461504	0.531992823294518	NA	NA	p.Gly45Asn	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-2.213	-4.367	2.154	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45P	45	G	P	missense	possibly_wt-like	0.986655989173044	0.283436519084875	2	0.200419884680826	0.593840233412955	1.37947174493313	0.786236104492218	1.18707587385387	NA	NA	NA	NA	NA	NA	0.677367563183837	0.640747736957629	0.713987389410046	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly45Pro	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-2.213	-2.135	-0.078	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45Q	45	G	Q	missense	possibly_wt-like	0.780472363563963	0.279098912176755	6	0.113941653766484	0.557150825842722	1.0037939012852	1.15185277427119	1.06825695759011	0.659117301264957	0.4553005864829	NA	NA	0.56086956308701	0.787436998687613	0.632246549621652	0.718623637858992	0.688297341267848	0.615738999673992	0.543929678498035	NA	NA	0.60110543401458	0.648754099569312	NA	NA	p.Gly45Gln	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-2.213	-4.547	2.334	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45R	45	G	R	missense	possibly_low	0.696546537676745	0.114215929062271	6	0.0466284577834138	0.605156439766608	0.787936635586883	0.837432386576558	0.808704349959169	0.656067099089123	0.607212167648039	NA	NA	0.54665312567081	0.723210097116772	0.623502673049928	0.651652482062738	0.632179012678903	0.614826333420954	0.594243382460988	NA	NA	0.598181040697925	0.634309374523481	NA	NA	p.Gly45Arg	1	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-2.213	-3.609	1.396	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45S	45	G	S	missense	possibly_low	0.697350547856098	0.0834462775421804	6	0.0340668001521682	0.630580846489325	0.764120249222872	0.769623249011688	0.756042210784893	0.758793625129797	0.697024460287706	NA	NA	0.557007668793887	0.645612073128619	0.622391199981393	0.637209219176499	0.620792838379391	0.645563651213174	0.623989561583396	NA	NA	0.60031102276162	0.616857464292805	NA	NA	p.Gly45Ser	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-2.213	-3.459	1.246	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45T	45	G	T	missense	wt-like	1.02072214335757	0.132563893784316	6	0.0541189830146799	0.914650885768864	1.12679340094628	0.96146020046041	1.04749394077853	0.905758462186749	0.892677503797503	NA	NA	1.24812471581208	1.06881803711016	0.689164171315653	0.67807025384779	0.683808132661679	0.689537735366597	0.688790607264709	NA	NA	0.742477306349918	0.712037110795401	NA	NA	p.Gly45Thr	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-2.213	-2.6	0.387	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45V	45	G	V	missense	wt-like	0.962552909948295	0.0697483610870587	6	0.028474649176448	0.906743623090044	1.01836219680655	0.960827328553478	0.937817132255338	0.919616781273618	0.877883513542922	NA	NA	1.07719361735833	1.00197908670609	0.688787566377687	0.677935452910138	0.660094715811548	0.693684352353045	0.683890780402328	NA	NA	0.70731591202217	0.697004932108188	NA	NA	p.Gly45Val	1	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-2.213	-1.624	-0.589	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45W	45	G	W	missense	possibly_wt-like	0.748859774222875	0.066503324116239	6	0.0271498683806188	0.69564701001186	0.802072538433891	0.722435731939301	0.693501780467304	0.75619810133802	0.867555986053784	NA	NA	0.686553058892794	0.766913986646047	0.635648389965023	0.627158336087574	0.607270861271587	0.644787031554163	0.68047026330434	NA	NA	0.626959166872401	0.644138443842471	NA	NA	p.Gly45Trp	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-2.213	-5.8	3.587	0.007838928	NA	NA	NA	NA	NA	NA	NA
G45X	45	G	X	nonsense	low	0.16598594270744	0.189605406513044	6	0.077406083071656	0.0142728077026786	0.317699077712201	0.130407431449306	0.0346977275908213	0.468106231650998	0.321286839389593	NA	NA	-0.0219682163184921	0.0633856424824134	0.492728843202734	0.501057036363922	0.464829671208029	0.558585621916123	0.499543806489442	NA	NA	0.481212745228457	0.485913879916026	NA	NA	p.Gly45Ter	1	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G45Y	45	G	Y	missense	wt-like	0.825039616632195	0.0925114773550619	6	0.0377676524784904	0.751016377993729	0.899062855270661	0.814213084786283	0.932912089366082	0.758528582678033	0.722001999747142	NA	NA	0.779530976988173	0.943050966227455	0.646395997888972	0.64670679934452	0.65903418780871	0.645484346535188	0.632262219378452	NA	NA	0.646085196433424	0.683751910757896	NA	NA	p.Gly45Tyr	0	24.6	12.3	28.8	0.022	43.7	-35.7	85.8	169.3	4.12371134020619	-1.9	0	0	17.15	0	0	0	0	6	15.6091138648108	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-2.213	-4.6	2.387	0.007838928	NA	NA	NA	NA	NA	NA	NA
H46A	46	H	A	missense	wt-like	0.921304548341225	0.204239463853137	6	0.0833804119632991	0.757881943877046	1.0847271528054	0.910460637820529	0.867593058039696	1.17434280069684	1.14773407709192	NA	NA	0.759627436866965	0.668069279531399	0.65605942710113	0.667207409742358	0.644911444459902	0.769902199006	0.773266332052212	NA	NA	0.641990937231613	0.621908123188873	NA	NA	p.His46Ala	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.693	-3.626	1.933	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46C	46	H	C	missense	low	0.387067275966148	0.243435553788887	3	0.14054758251034	0.111599076131711	0.662535475800586	0.487232640736595	0.109529007534319	NA	NA	NA	NA	NA	0.564440179627531	0.577060366995329	0.577060366995329	0.481009074662807	NA	NA	NA	NA	NA	0.598601785528985	NA	NA	p.His46Cys	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.693	-5.432	3.739	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46D	46	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His46Asp	1	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.693	-3.159	1.466	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46E	46	H	E	missense	possibly_wt-like	0.740664537568555	0.171888548482068	6	0.0701732060681193	0.603127580995334	0.878201494141776	0.947580450487925	0.95711621389451	0.645238690452342	0.66650137856878	NA	NA	0.538759276988782	0.688791215018992	0.620224357904677	0.675113884177757	0.664267404403573	0.611586311098765	0.613880198716758	NA	NA	0.596557235967345	0.626568517092596	NA	NA	p.His46Glu	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.693	-3.015	1.322	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46F	46	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His46Phe	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.693	-4.473	2.78	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46G	46	H	G	missense	possibly_wt-like	0.755338591647896	0.119943907672936	6	0.0489668952590314	0.659365240505449	0.851311942790343	0.805880430791826	0.964700909086195	0.690490937425747	0.614664398263114	NA	NA	0.722127355567537	0.734167518752957	0.635525347527061	0.644931954294074	0.665907304772515	0.625126462310369	0.596711590099634	NA	NA	0.63427698021724	0.636773714836883	NA	NA	p.His46Gly	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.693	-3.655	1.962	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46I	46	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His46Ile	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.693	-4.268	2.575	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46K	46	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His46Lys	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.693	-3.812	2.119	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46L	46	H	L	missense	possibly_low	0.695395989307428	0.182647994564225	6	0.0745657315374979	0.54924984101305	0.841542137601806	0.924743225403729	0.879924231612363	0.682075622967632	0.679506470391936	NA	NA	0.449505259463317	0.556621126005591	0.620398004730534	0.670249583327924	0.64757758931876	0.622608473969966	0.618187535491102	NA	NA	0.57819723165018	0.596843268818305	NA	NA	p.His46Leu	1	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.693	-3.074	1.381	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46M	46	H	M	missense	wt-like	0.909936312358728	0.114602019100495	6	0.0467860783814839	0.818237283753151	1.0016353409643	0.732519362122614	0.874856537980073	0.867815017026934	0.920360867614682	NA	NA	1.05715922762639	1.00690686178167	0.688071965938309	0.629306136912291	0.646481894310951	0.678184487311201	0.697959444565416	NA	NA	0.703194736391447	0.6981131960025	NA	NA	p.His46Met	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.693	-3.146	1.453	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46N	46	H	N	missense	wt-like	1.27834071803239	0.0705882138217554	2	0.0499134046652092	1.18051224254281	1.37616919352198	1.22842731336718	1.3282541226976	NA	NA	NA	NA	NA	NA	0.739722854452056	0.734933920488645	0.744511788415467	NA	NA	NA	NA	NA	NA	NA	NA	p.His46Asn	1	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.693	-1.497	-0.196	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46P	46	H	P	missense	possibly_wt-like	0.839161802743553	0.197622744086847	6	0.0806791474302328	0.681033579476899	0.997290026010206	0.703160004946744	0.605461432859148	0.810645034146877	0.760854598113692	NA	NA	1.10638680633086	1.048462940064	0.653104360565082	0.623052629950101	0.58823550192284	0.661078370715139	0.645130350415025	NA	NA	0.713321099132258	0.707459219399085	NA	NA	p.His46Pro	1	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.693	-3.627	1.934	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46Q	46	H	Q	missense	possibly_low	0.71892533628374	0.218256607863869	6	0.0891028870428663	0.544286886761181	0.893563785806298	0.752488720294599	1.13279300178052	0.669508708709442	0.668584255775362	NA	NA	0.558358659068537	0.531818672073982	0.616709160198353	0.633559585637716	0.702250793582445	0.61884826468314	0.614570055713567	NA	NA	0.600588928316604	0.591265160288364	NA	NA	p.His46Gln	1	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.693	-3.228	1.535	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46R	46	H	R	missense	possibly_low	0.703609983093516	0.139838833908463	6	0.0570889648835903	0.591717668007008	0.815502298180025	0.532703772378479	0.915252042481926	0.687153292188281	0.691817708674079	NA	NA	0.58946528646391	0.805267796374423	0.623196427033248	0.586745662098961	0.655215877821433	0.624127788780798	0.622265065285698	NA	NA	0.606987719419857	0.652764272310554	NA	NA	p.His46Arg	1	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.693	-4.038	2.345	0.006647649	NA	NA	NA	NA	4.06e-06	NA	NA
H46S	46	H	S	missense	wt-like	1.34295890353766	0.246181385069409	6	0.100503129598612	1.14597638919082	1.5399414178845	1.06314990707821	1.04911678777535	1.36133413136248	1.3775508117734	NA	NA	1.57780620933336	1.62879557390318	0.818073636535741	0.699730036264287	0.684159011282582	0.825852810562591	0.849382524549261	NA	NA	0.81029446250889	0.837976886076254	NA	NA	p.His46Ser	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.693	-2.62	0.927	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46T	46	H	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His46Thr	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.693	-2.6	0.907	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46V	46	H	V	missense	possibly_wt-like	0.781492254990633	0.203406833466774	6	0.0830404920314782	0.61873588135045	0.944248628630815	1.03945534292037	0.800692137960929	0.663024117787486	0.695445277316816	NA	NA	0.504460545766041	0.985876108192157	0.626956604106357	0.694683123246418	0.6304466781447	0.616907977791302	0.623466530068015	NA	NA	0.589501812908735	0.693383348451438	NA	NA	p.His46Val	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.693	-3.986	2.293	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46W	46	H	W	missense	wt-like	1.00106205848846	0.0744695383506264	6	0.0304020617232763	0.941475112455079	1.06064900452185	0.982028751546253	0.992700220209448	0.975567908057361	1.07991614382595	NA	NA	0.887851499026596	1.08830782826518	0.696438549422713	0.682451329926772	0.671961085376843	0.710425768918653	0.750804769928033	NA	NA	0.668367277480315	0.716420393618476	NA	NA	p.His46Trp	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.693	-5.695	4.002	0.006647649	NA	NA	NA	NA	NA	NA	NA
H46X	46	H	X	nonsense	low	0.458183671003632	0.113100879776033	6	0.0461732408185242	0.367685781949829	0.548681560057434	0.516897038301956	0.539718625344806	0.269424085541429	0.412553141465782	NA	NA	0.4287033698053	0.581805765562517	0.573969655282292	0.583378847185238	0.574021133174537	0.499136942981998	0.52977155916791	NA	NA	0.573918177390047	0.602507331459984	NA	NA	p.His46Ter	0	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H46Y	46	H	Y	missense	possibly_wt-like	0.852105591620383	0.177518188562316	6	0.0724714970068074	0.710064067581338	0.994147115659427	0.771318458417688	0.946052014577851	0.883403695757975	0.601425660434051	NA	NA	0.786209200073448	1.12422452046128	0.654667067550375	0.637570296694624	0.66187519429059	0.682848853863683	0.592326868863334	NA	NA	0.647458940810159	0.724498110753193	NA	NA	p.His46Tyr	1	27.8	13.1	27.2	0.446	46	-158.2	-73.1	121.9	0.462962962962963	-2.6	0	0	15.14	1	191	0	0	5	15.5450196411786	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.693	-3.631	1.938	0.006647649	NA	NA	NA	NA	NA	NA	NA
Q47A	47	Q	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln47Ala	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.605	-2.548	-0.057	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47C	47	Q	C	missense	wt-like	0.893628620769177	0.199541665749365	6	0.0814625439184898	0.733964968599924	1.05329227293843	0.65864029161539	0.784724273893212	0.721691632805996	1.14843540723743	NA	NA	1.06566964348939	0.982610475573645	0.663555540660898	0.61356998577623	0.626994237998578	0.634462178470587	0.773498615312321	NA	NA	0.704945372119872	0.692648902851208	NA	NA	p.Gln47Cys	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.605	-5.519	2.914	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47D	47	Q	D	missense	possibly_wt-like	0.84137307870274	0.18159527493197	6	0.0741359605472918	0.696069266070766	0.986676891334714	1.01274142890854	0.913721105293884	0.836563985621472	1.02025418033034	NA	NA	0.558358282874643	0.706599489187554	0.661859290519988	0.68899309242389	0.654884871182926	0.66883370985705	0.731044496575973	NA	NA	0.600588850931611	0.63057362426131	NA	NA	p.Gln47Asp	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.605	-3.314	0.709	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47E	47	Q	E	missense	wt-like	0.97502390656257	0.247961692381215	6	0.101229937015157	0.776616875855604	1.17343093726954	0.665342346908333	0.944699445775509	1.41984427696877	0.976683818425719	NA	NA	0.981227761841818	0.862345789455272	0.676588222923733	0.614997515309126	0.661582752996388	0.843359923952735	0.716613823985942	NA	NA	0.687575248571577	0.665601197275888	NA	NA	p.Gln47Glu	1	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.605	-2.49	-0.115	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47F	47	Q	F	missense	possibly_wt-like	0.938765200690456	0.371449522462072	6	0.151643632538759	0.641549142429663	1.23598125895125	1.48653023267054	1.07178409532682	0.496537034703737	1.01998632047001	NA	NA	1.02264092354482	0.53511259742681	0.692577048020471	0.789909524796217	0.689059949959372	0.567092544735396	0.730955780352938	NA	NA	0.69609414608157	0.592005968966339	NA	NA	p.Gln47Phe	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.605	-4.049	1.444	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47G	47	Q	G	missense	wt-like	0.910383085758095	0.103812468333549	6	0.0423812627260055	0.827317337195794	0.993448834320395	0.905275837447149	0.938830888620911	0.887654832475242	0.723685576285553	NA	NA	1.01690522134051	0.989946158379199	0.675111955694981	0.666103053640885	0.660313901869248	0.684120857749077	0.632819826447662	NA	NA	0.694914283032795	0.694298708751198	NA	NA	p.Gln47Gly	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.605	-3.116	0.511	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47H	47	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln47His	1	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.605	-3.566	0.961	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47I	47	Q	I	missense	wt-like	1.23458776609594	0.16801866543264	6	0.068593332928895	1.10014730397574	1.36902822821614	1.09715888741147	0.995046646834343	1.36262911860906	1.33448329637556	NA	NA	1.4261632309071	1.1920454164381	0.759425931398561	0.70697390723929	0.672468410429546	0.826240290175397	0.835118396669559	NA	NA	0.779100732346778	0.739751130450344	NA	NA	p.Gln47Ile	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.605	-4.37	1.765	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47K	47	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln47Lys	1	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.605	-2.634	0.029	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47L	47	Q	L	missense	wt-like	1.1270670693969	0.125945746435721	6	0.0514171356735783	1.02629133528848	1.22784280350533	0.895569469645691	1.10615782067487	1.18685754762757	1.24619569810804	NA	NA	1.21288519160989	1.11473668871536	0.728796320389299	0.664035609239415	0.696491953943131	0.773646799045787	0.805877202227621	NA	NA	0.735228357401459	0.722364283377138	NA	NA	p.Gln47Leu	1	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.605	-3.421	0.816	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47M	47	Q	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln47Met	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.605	-3.978	1.373	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47N	47	Q	N	missense	wt-like	0.956845101012747	0.242644194799136	6	0.0990590777177277	0.762692876344246	1.15099732568125	1.25401306073159	1.00383182286455	1.14182532953277	0.825780745280586	NA	NA	0.949171842824085	0.566447804842896	0.677674526124704	0.740383653203081	0.674367868884905	0.760172483775744	0.666634141784685	NA	NA	0.680981183364503	0.59905330340579	NA	NA	p.Gln47Asn	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.605	-3.41	0.805	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47P	47	Q	P	missense	wt-like	1.17263536976671	0.0902796743102375	6	0.0368565227007888	1.10039791267778	1.24487282685564	1.2811475675851	1.17395306535686	1.19229966512458	1.01854900376217	NA	NA	1.23259582809579	1.13726708867577	0.734881335419936	0.746163269783498	0.711150083763353	0.775275162248706	0.730479735493259	NA	NA	0.739282935346613	0.727431403612448	NA	NA	p.Gln47Pro	1	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.605	-1.82	-0.785	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47R	47	Q	R	missense	wt-like	0.940644204139534	0.216928216657216	6	0.0885605736036828	0.767068669426107	1.11421973885296	1.15305564803021	1.26270606057168	0.834982092874715	0.894121683791935	NA	NA	0.754277697614176	0.744722041954492	0.678814654542825	0.718879848489955	0.730339525912207	0.668360383814164	0.689268925271485	NA	NA	0.640890468720502	0.63914744269713	NA	NA	p.Gln47Arg	1	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.605	-2.73	0.125	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47S	47	Q	S	missense	wt-like	0.850728915966321	0.110592707659766	6	0.0451492838398693	0.762237945712401	0.939219886220241	0.918372022910197	0.950499234305434	0.750568777933412	0.877837057765339	NA	NA	0.928857986276044	0.678238416607501	0.665864630285902	0.668892525034305	0.662836735537498	0.643102653535051	0.683875394068892	NA	NA	0.676802519991575	0.624195177140178	NA	NA	p.Gln47Ser	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.605	-2.628	0.023	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47T	47	Q	T	missense	possibly_wt-like	0.94541351691302	0.330933073641086	6	0.135102861571925	0.680616774023746	1.21021025980229	0.4227814572647	0.826661140885185	0.884611636198279	0.977387945933993	NA	NA	1.15596850763587	1.40507041356009	0.700028660754762	0.563332344200124	0.636061482220577	0.683210287766091	0.716847033743432	NA	NA	0.723520306688968	0.787660767005399	NA	NA	p.Gln47Thr	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.605	-2.651	0.046	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47V	47	Q	V	missense	wt-like	1.29917872377819	0.15858165352829	6	0.064740688951857	1.17228930509824	1.42606814245814	1.09337932988219	1.37016323201144	1.20827726203939	1.24904904510372	NA	NA	1.31559672095157	1.55860675268084	0.768206269572473	0.706168866134958	0.753573031100756	0.780055898956689	0.806822241802243	NA	NA	0.756356640188257	0.822191316493244	NA	NA	p.Gln47Val	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.605	-3.23	0.625	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47W	47	Q	W	missense	wt-like	0.962028595984186	0.179208872449692	6	0.0731617158135432	0.818634267942487	1.10542292402589	1.31488661104985	0.956082566541121	0.86963290149114	0.843040309217087	NA	NA	0.848680226804081	0.939848960801841	0.675539500907514	0.75334964453757	0.664043917680199	0.678728425616519	0.672350576198509	NA	NA	0.660309548012742	0.683031775007345	NA	NA	p.Gln47Trp	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.605	-4.433	1.828	0.007070206	NA	NA	NA	NA	NA	NA	NA
Q47X	47	Q	X	nonsense	possibly_low	0.710884276427361	0.215350814862107	6	0.0879166020174552	0.538570902830008	0.883197650024715	1.07105583226124	0.848581848211858	0.625960714842052	0.597870244503177	NA	NA	0.656396389274954	0.465440629470885	0.613286919237073	0.701413988602837	0.640800997141611	0.605818051569677	0.5911493013386	NA	NA	0.620755786904469	0.576336640446492	NA	NA	p.Gln47Ter	1	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q47Y	47	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln47Tyr	0	30.7	13.2	29.7	0.82	90.2	51.9	-76.6	-27	51.4018691588785	-2.9	1	0	15.41	1	2	0	0	5	19.1863933606627	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.605	-4.009	1.404	0.007070206	NA	NA	NA	NA	NA	NA	NA
L48A	48	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Ala	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.847	-2.967	1.12	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48C	48	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Cys	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.847	-3.825	1.978	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48D	48	L	D	missense	possibly_wt-like	0.7267306533774	0.312341723990486	6	0.127512974859651	0.476809815090922	0.976651491663878	0.703007559765693	0.295260392123164	0.926221184533239	1.18214710209676	NA	NA	0.757092909018094	0.496654772727449	0.632244865652957	0.623020159314066	0.521166385986979	0.69566048889385	0.784664059199039	NA	NA	0.641469571991847	0.583356747377619	NA	NA	p.Leu48Asp	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.847	-3.345	1.498	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48E	48	L	E	missense	possibly_low	0.711266403011177	0.277997400981982	6	0.113491963704291	0.48882624161604	0.933706564406315	0.637392137024653	0.983693653263299	0.788841619410526	0.821516133274637	NA	NA	0.191028594916493	0.845126280177455	0.658141483055693	0.609044154986716	0.670013759599785	0.6545544619105	0.665221685773507	NA	NA	0.525027270134307	0.661728504200886	NA	NA	p.Leu48Glu	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.847	-3.698	1.851	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48F	48	L	F	missense	low	0.352367276842255	0.395626610421924	6	0.161513887366763	0.0358058746003408	0.66892867908417	0.751528853917056	0.877224473325721	0.0563964000695144	-0.146376365862336	NA	NA	0.248387952095911	0.327042347507666	0.54101852167416	0.633355135280074	0.646993869802229	0.43539586344526	0.344651941873585	NA	NA	0.536826380971457	0.545210662376863	NA	NA	p.Leu48Phe	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.847	-2.511	0.664	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48G	48	L	G	missense	wt-like	0.980724200158989	0.16266058845332	6	0.0664059071619139	0.850571013760927	1.11087738655705	1.00816885636773	0.829604421066882	1.15228096567678	1.17403071612642	NA	NA	0.780077195997796	0.940183045718322	0.685563025648115	0.688019140097624	0.636697854036963	0.763300966975408	0.781975880734774	NA	NA	0.646197556455447	0.683106911198606	NA	NA	p.Leu48Gly	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.847	-3.214	1.367	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48H	48	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48His	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.847	-3.16	1.313	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48I	48	L	I	missense	possibly_wt-like	0.977904344386567	0.593329353395273	4	0.296664676697636	0.39645226257398	1.55935642619915	1.00883089121806	1.62884010501765	NA	1.08361468327825	NA	NA	0.190331698032296	NA	0.720094946611829	0.688160152706347	0.809502015556827	NA	0.752029740517312	NA	NA	0.524883914908882	NA	NA	NA	p.Leu48Ile	1	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.847	-2.917	1.07	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48K	48	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Lys	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.847	-3.287	1.44	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48L	48	L	L	synonymous	wt-like	1.30881251656223	0.20852207030265	6	0.0851287787250423	1.14196317621327	1.47566185691119	0.974480706300348	1.25041329855513	1.2849517493209	1.39561329066019	NA	NA	1.61465885468747	1.33275719984936	0.787197737154066	0.680843605574585	0.72768168608387	0.802998055894754	0.855364887503925	NA	NA	0.817875238663951	0.771397418413378	NA	NA	p.Leu48=	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48M	48	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Met	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.847	-2.802	0.955	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48N	48	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Asn	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.847	-3.667	1.82	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48P	48	L	P	missense	possibly_low	0.432611041917455	0.412265075144255	2	0.291515430280884	-0.138748702370775	1.00397078620568	NA	NA	NA	NA	NA	NA	0.14109561163657	0.724126472198339	0.574635635362947	NA	NA	NA	NA	NA	NA	0.514755802092807	0.634515468633088	NA	NA	p.Leu48Pro	1	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.847	-4.565	2.718	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48Q	48	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Gln	1	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.847	-3.149	1.302	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48R	48	L	R	missense	possibly_low	0.671056745394441	0.0967516987190373	6	0.0394987156015217	0.593640685379869	0.748472805409014	0.754039174323335	0.682025957351249	0.583763913829964	0.660037039174695	NA	NA	0.799821292024736	0.54665309566267	0.60826441886234	0.633889830438553	0.604789653248545	0.593192135630399	0.611739184476135	NA	NA	0.650259017197981	0.594601444068388	NA	NA	p.Leu48Arg	1	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.847	-3.691	1.844	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48S	48	L	S	missense	wt-like	0.842572820616991	0.102399040244807	6	0.0418042331250827	0.760638029290512	0.924507611943469	0.85724747675217	0.723697946679601	0.861031732387079	0.788771687177679	NA	NA	1.02439290567285	0.800295175032567	0.655124835158644	0.655873071894707	0.613799627802176	0.676154826777681	0.654376598422581	NA	NA	0.696454537695595	0.651645922424706	NA	NA	p.Leu48Ser	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.847	-2.99	1.143	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48T	48	L	T	missense	wt-like	0.871586734419194	0.101464378895468	6	0.0414226592270526	0.790399814190295	0.952773654648093	0.808750654202815	0.927665993902043	0.845464538098407	0.903032557232603	NA	NA	0.726170500412944	1.01843616266635	0.664698404458926	0.645543308349823	0.657899920225167	0.671496888692686	0.692220241062595	NA	NA	0.635108675628546	0.700706152803728	NA	NA	p.Leu48Thr	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.847	-3.492	1.645	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48V	48	L	V	missense	possibly_wt-like	0.960185172550503	0.323154766705971	6	0.131927381062961	0.701612257092408	1.2187580880086	1.04507826052194	1.33952423183775	0.929598593702639	0.806994378988517	NA	NA	0.427969482027532	1.21194608822464	0.696275929083491	0.695880797778548	0.746948518655755	0.696671060388433	0.66041202451812	NA	NA	0.573767212950107	0.744226820934447	NA	NA	p.Leu48Val	1	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.847	-3.004	1.157	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48W	48	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Trp	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.847	-3.829	1.982	0.007461554	NA	NA	NA	NA	NA	NA	NA
L48X	48	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Ter	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L48Y	48	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu48Tyr	0	33	15.4	27.6	0.91	112.1	47.1	-72	-38.9	9.42408376963351	-2.5	1	0	15.58	0	0	0	0	6	19.4166638649545	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.847	-2.288	0.441	0.007461554	NA	NA	NA	NA	NA	NA	NA
L49A	49	L	A	missense	possibly_low	0.646930197355164	0.186104811417607	6	0.0759769711083376	0.498018070328382	0.795842324381946	0.86795028648674	0.773249201675007	0.641240008301568	0.317990027913374	NA	NA	0.645765445271293	0.635386214483002	0.616563300676893	0.658152757202161	0.624513192328489	0.610389845407228	0.498451889761541	NA	NA	0.618568947777065	0.614557653576722	NA	NA	p.Leu49Ala	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-0.883	-3.437	2.554	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49C	49	L	C	missense	possibly_low	0.601733719886578	0.243251050399085	6	0.0993068254789655	0.407095918528801	0.796371521244355	0.832363612190965	0.847444812745583	0.56862842980954	0.661957828626764	NA	NA	0.190579088580676	0.509428547365939	0.600519364557776	0.650572839353935	0.6405551566914	0.58866337173459	0.612375357380962	NA	NA	0.524934804400047	0.586229588164542	NA	NA	p.Leu49Cys	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-0.883	-5.03	4.147	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49D	49	L	D	missense	possibly_low	0.519759543489993	0.565660364152708	4	0.282830182076354	-0.0345774271205674	1.07409651410055	1.06237251165977	0.948412165918272	NA	0.1050655071298	NA	NA	NA	-0.0368120107478746	0.562882383235317	0.699564451996468	0.662385486788324	NA	0.427930463922963	NA	NA	NA	0.463379279682311	NA	NA	p.Leu49Asp	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-0.883	-4.414	3.531	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49E	49	L	E	missense	low	0.350027648535641	0.211299475877318	6	0.0862626498028254	0.180955961711112	0.51909933536017	0.614959982201203	0.614400840621811	0.198300625212945	0.31572339149673	NA	NA	0.182780342658927	0.174000709022229	0.517060967291285	0.604266133604127	0.590168307093994	0.477855736590054	0.497701171002747	NA	NA	0.523330562789848	0.510791371792723	NA	NA	p.Leu49Glu	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-0.883	-4.192	3.309	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49F	49	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu49Phe	1	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-0.883	-2.812	1.929	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49G	49	L	G	missense	low	0.526202847273904	0.166104641222493	6	0.0678119358171962	0.393293895350257	0.65911179919755	0.723398376516386	0.659197830081339	0.395463494696192	0.353043624695251	NA	NA	0.643359390936072	0.382754366718182	0.578797160628327	0.627363378198301	0.599853943455852	0.536849825163954	0.510061776761551	NA	NA	0.618074010190985	0.557740377800803	NA	NA	p.Leu49Gly	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-0.883	-4.104	3.221	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49H	49	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu49His	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-0.883	-5.19	4.307	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49I	49	L	I	missense	possibly_low	0.654822128019588	0.34412641570486	6	0.140489020914966	0.379468706802961	0.930175549236216	0.794587099874145	1.11126262680084	0.626814265757459	0.801709583825443	NA	NA	0.0896632621356623	0.504895929723982	0.624299967755196	0.642526488701044	0.69759567310887	0.606073446809348	0.65866167989462	NA	NA	0.50417590681124	0.58521019576082	NA	NA	p.Leu49Ile	1	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-0.883	-2.325	1.442	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49K	49	L	K	missense	possibly_low	0.663897706077748	0.0897720325042897	6	0.0366492788013426	0.592066439567749	0.735728972587746	0.511094476693044	0.687085486689176	0.699151676266087	0.609428263380949	NA	NA	0.762014483698407	0.714611849738823	0.616800734173923	0.582142908700532	0.605883583039822	0.627717885308024	0.594977361949609	NA	NA	0.642481964877714	0.632375615985969	NA	NA	p.Leu49Lys	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-0.883	-4.026	3.143	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49L	49	L	L	synonymous	possibly_wt-like	0.822477817114027	0.365229354315747	6	0.149104259526624	0.53023883850033	1.11471679572772	0.975368187768137	1.09951765290255	0.636972248933141	1.25572926846329	NA	NA	0.723529635661907	0.243749908955136	0.65779903719195	0.681032638035493	0.695056271518924	0.609112867775218	0.809034757648249	NA	NA	0.634565436348407	0.526478069898288	NA	NA	p.Leu49=	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49M	49	L	M	missense	wt-like	1.07299631881535	0.190006522272606	6	0.0775698378947754	0.92096223025498	1.22503040737572	1.02454555761336	1.32157577085264	1.12334197806012	1.23752800529195	NA	NA	0.883559925091328	0.847426675982695	0.717287603731285	0.691507357317225	0.743067850145346	0.754641987710344	0.803006428801095	NA	NA	0.667484478944591	0.662245866615865	NA	NA	p.Leu49Met	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-0.883	-2.928	2.045	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49N	49	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu49Asn	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-0.883	-4.446	3.563	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49P	49	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu49Pro	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-0.883	-4.439	3.556	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49Q	49	L	Q	missense	possibly_wt-like	0.897246946509535	0.330315599672966	4	0.165157799836483	0.573543607064153	1.22095028595492	0.499962168593512	0.752450101343957	NA	NA	NA	NA	1.19655100261686	1.14002451348381	0.674033867283025	0.579771740769686	0.620016182040725	NA	NA	NA	NA	0.731868331839092	0.728051552525326	NA	NA	p.Leu49Gln	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-0.883	-4.46	3.577	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49R	49	L	R	missense	low	0.408812078215745	0.307961830629117	6	0.125724890882459	0.162395820125898	0.655228336305592	0.791672118726823	0.73455436923842	0.228892203516067	0.48538459605369	NA	NA	0.0987250044724472	0.113644177287024	0.529966786080938	0.641905601302514	0.616146914134674	0.487009195782243	0.553893618968893	NA	NA	0.506039953192983	0.497217098640632	NA	NA	p.Leu49Arg	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-0.883	-3.511	2.628	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49S	49	L	S	missense	possibly_wt-like	0.790014006926939	0.130289627576506	6	0.0531905177232821	0.685762507870266	0.894265505983611	0.917475652029368	0.930070127230801	0.848131901775033	0.603122654983695	NA	NA	0.697364301501749	0.743919404040984	0.648693325195535	0.668701599139355	0.658419722146428	0.672295003923054	0.592888920029827	NA	NA	0.629183094337825	0.638966928244643	rs72552740	*5	p.Leu49Ser	1	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-0.883	-3.953	3.07	0.003373759	NA	NA	0.3	NA	NA	NA	NA
L49T	49	L	T	missense	low	0.602225207862016	0.142522997525231	6	0.0581847700914609	0.488185154034009	0.716265261690022	0.488203837729184	0.869013101462582	0.589087492322038	0.499683367839242	NA	NA	0.638509732171869	0.52885371564718	0.592691683696222	0.577267230760038	0.645218474561212	0.594785030184605	0.558629427556587	NA	NA	0.617076410773993	0.590598337207839	NA	NA	p.Leu49Thr	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-0.883	-3.781	2.898	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49V	49	L	V	missense	possibly_low	0.699929249247551	0.178341423970476	6	0.0728075814548376	0.557229011794603	0.8426294867005	0.927275687679803	0.83291780866374	0.455613122778514	0.787258549729086	NA	NA	0.569411258929496	0.62709906770467	0.62505405472808	0.670788994677432	0.637414247432507	0.554847496307999	0.653875441439948	NA	NA	0.602862504193513	0.612693862023654	NA	NA	p.Leu49Val	1	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-0.883	-2.391	1.508	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49W	49	L	W	missense	possibly_wt-like	0.72976283482162	0.136429290587868	6	0.0556970246516949	0.620598672458258	0.838926997184981	0.697880117834123	0.852577894836995	0.748952465862218	0.898017059521172	NA	NA	0.659641116381846	0.521508354493365	0.631796504971902	0.62192802049014	0.641664989453664	0.642619028713902	0.69055908879794	NA	NA	0.621423243735458	0.588946354633027	NA	NA	p.Leu49Trp	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-0.883	-5.424	4.541	0.003373759	NA	NA	NA	NA	NA	NA	NA
L49X	49	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu49Ter	1	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L49Y	49	L	Y	missense	possibly_low	0.717303475164643	0.210600154648916	6	0.0859771531068453	0.54879135158194	0.885815598747346	0.912781209349098	1.01685141182081	0.674030574380326	0.655639705690077	NA	NA	0.599918282681486	0.444599667066059	0.615242022665222	0.667701688623303	0.67718285725204	0.620201274733189	0.610282770597256	NA	NA	0.609137953784682	0.571649477213245	NA	NA	p.Leu49Tyr	0	30.3	17.9	27.1	0.937	109.7	54.1	-64.7	-42.5	0	-2.3	1	0	15.16	0	0	0	0	8	18.1880435053834	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-0.883	-4.211	3.328	0.003373759	NA	NA	NA	NA	NA	NA	NA
K50A	50	K	A	missense	wt-like	0.932293784966335	0.11874437087031	6	0.0484771864100109	0.837280245530879	1.02730732440179	1.02653335702922	0.977975970749188	0.958318758110941	1.04648273867039	NA	NA	0.734872861918831	0.849579023319446	0.680354142746583	0.691930756147521	0.668777529345645	0.705264564466564	0.739731496668885	NA	NA	0.636898795549726	0.662729932711568	NA	NA	p.Lys50Ala	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.382	-2.79	0.408	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50C	50	K	C	missense	wt-like	1.05975901591127	0.172132455155241	6	0.0702727805504747	0.92202689693885	1.19749113488368	0.918112507869164	0.859048731798835	1.22803934556148	1.19055096973957	NA	NA	1.22534219618899	0.937460344309555	0.710142699042474	0.668837248649806	0.643064060563696	0.785969010836035	0.787447452706506	NA	NA	0.737790826455426	0.682494571629521	NA	NA	p.Lys50Cys	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.382	-3.985	1.603	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50D	50	K	D	missense	wt-like	0.901516244572991	0.191803954142629	6	0.0783036363829376	0.748043937403913	1.05498855174207	0.912896646034787	0.943835874835701	0.698516526159597	0.762600087235455	NA	NA	1.24560235122325	0.845645981949152	0.661620712346226	0.667726276495351	0.661396038795355	0.627527838867037	0.6457084631716	NA	NA	0.741958443154465	0.661845385897098	NA	NA	p.Lys50Asp	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.382	-3.487	1.105	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50E	50	K	E	missense	wt-like	1.06609844261091	0.126569130093068	6	0.0516716309859935	0.964823906855915	1.1673729783659	1.10066418044042	1.08256454727542	1.15171727441831	0.936764405119214	NA	NA	1.22758877910063	0.89729146931144	0.705556445026213	0.707720530342436	0.691390810551801	0.763132302093842	0.70339235970999	NA	NA	0.738252959960451	0.673460532300874	NA	NA	p.Lys50Glu	1	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.382	-2.664	0.282	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50F	50	K	F	missense	possibly_low	0.674895413192474	0.289794501328222	6	0.118308109753074	0.443015778997436	0.906775047387511	0.906957190247297	1.10095264972416	0.612611788328975	0.679669974853096	NA	NA	0.385962008129852	0.363218867871466	0.610032770642755	0.666461179719008	0.695366534721031	0.601823852483698	0.618241688801812	NA	NA	0.56512606240588	0.553346815250339	NA	NA	p.Lys50Phe	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.382	-4.681	2.299	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50G	50	K	G	missense	possibly_wt-like	0.812150753427732	0.198744221804673	6	0.0811369887913286	0.653125177582698	0.971176329272766	0.848300030172647	1.02070252174308	0.796435442222675	0.539344160326141	NA	NA	1.03035837626643	0.637763989835417	0.655396962202779	0.653967276779926	0.67801551254309	0.656826647625633	0.571765235615571	NA	NA	0.697681665267985	0.615092418766173	NA	NA	p.Lys50Gly	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.382	-3.67	1.288	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50H	50	K	H	missense	possibly_low	0.287332746995588	0.696441315504985	4	0.348220657752493	-0.395167200872146	0.969832694863322	1.02535904304911	0.725690909649747	NA	NA	NA	NA	-0.186162865035746	-0.415556099680759	0.53083380132384	0.691680628714334	0.614230529852612	NA	NA	NA	NA	0.447437072795067	0.37819917456179	NA	NA	p.Lys50His	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.382	-3.903	1.521	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50I	50	K	I	missense	possibly_low	0.642791760533204	0.205370919026951	6	0.0838423266037451	0.478463820009819	0.807119701056588	0.794707031779596	0.932291194821488	0.508425827036661	0.357747065693949	NA	NA	0.584613838414309	0.678965605453219	0.615174237461819	0.642552034049371	0.658899943100516	0.570649849768355	0.511619574634502	NA	NA	0.60598975193778	0.624358722985858	NA	NA	p.Lys50Ile	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.382	-2.541	0.159	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50L	50	K	L	missense	low	0.184545080092274	0.36130750974178	3	0.20860098800965	-0.224305343546111	0.59339550373066	0.137836108136204	0.566935526037987	NA	NA	NA	NA	-0.151136393897368	NA	0.502639335359881	0.502639335359881	0.579905747435259	NA	NA	NA	NA	0.454642195647181	NA	NA	NA	p.Lys50Leu	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.382	-2.665	0.283	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50M	50	K	M	missense	wt-like	1.02175280769326	0.0833502153074549	6	0.0340275829090634	0.955059970710545	1.08844564467598	1.06544583075923	0.977858580990628	0.951907884473492	1.09619392131813	NA	NA	1.12072610531341	0.918384523304679	0.701782700038126	0.700219065184024	0.668752148298219	0.703346334892228	0.756196032869505	NA	NA	0.716270765696562	0.67820439130477	NA	NA	p.Lys50Met	1	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.382	-3.562	1.18	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50N	50	K	N	missense	wt-like	1.01422452719434	0.173586884251738	6	0.0708665487427204	0.875328643949958	1.15312041043873	0.992893536522073	1.13856612339595	0.934024288763012	0.879958235661322	NA	NA	0.841834689383217	1.29807028944047	0.691380405255167	0.684765515761359	0.703499010422785	0.697995294748975	0.684577936402351	NA	NA	0.658901386228153	0.763596281019368	NA	NA	p.Lys50Asn	1	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.382	-2.884	0.502	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50P	50	K	P	missense	possibly_low	0.522679487410241	0.296563149697302	6	0.121071398878502	0.285383906050494	0.759975068769988	0.877799087174808	0.894695938681442	0.216085245019667	0.32817791125318	NA	NA	0.315149179408138	0.504169562924213	0.567803169499216	0.660250539633266	0.650771406243538	0.483177161657972	0.501826156176495	NA	NA	0.550559504203944	0.585046834794488	NA	NA	p.Lys50Pro	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.382	-3.218	0.836	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50Q	50	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys50Gln	1	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.382	-2.47	0.088	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50R	50	K	R	missense	possibly_wt-like	0.848503151082164	0.173667530752457	6	0.0708994725387709	0.709542738383287	0.987463563781042	1.01059563627611	1.09504590880326	0.69781385056915	0.862384767559234	NA	NA	0.668432403908133	0.756746339377107	0.660304630332141	0.688536041232817	0.69408942781421	0.627317587788169	0.678757535713283	NA	NA	0.623231656190281	0.641851724950998	NA	NA	p.Lys50Arg	1	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.382	-2.893	0.511	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50S	50	K	S	missense	wt-like	0.941707610036698	0.0921545319242512	6	0.0376219301165731	0.867969981979332	1.01544523809406	0.890773263616509	1.01492318523728	0.91746918148516	0.81804382660505	NA	NA	1.0777878505526	0.931248352723585	0.678931718757577	0.663014023255228	0.676765951970307	0.693041758276008	0.664071644357954	NA	NA	0.70743814880562	0.681097485544847	NA	NA	p.Lys50Ser	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.382	-2.894	0.512	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50T	50	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys50Thr	1	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.382	-2.737	0.355	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50V	50	K	V	missense	wt-like	0.809586108606307	0.0932180528467793	6	0.0380561107150677	0.734997502213105	0.884174714999508	0.845805824320763	0.959368263186502	0.711708683386739	0.722865932577469	NA	NA	0.844940179941132	0.772827768225236	0.649452238028892	0.65343601400171	0.664754323966123	0.631475130230663	0.632548357277456	NA	NA	0.659540201394473	0.645468462056074	NA	NA	p.Lys50Val	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.382	-2.363	-0.019	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50W	50	K	W	missense	possibly_wt-like	0.773429083074672	0.196282525561641	6	0.0801320055084695	0.616373238269106	0.930484927880237	0.690593442324632	1.13890985213369	0.764655235081834	0.798103396494691	NA	NA	0.565225499037007	0.683087073376178	0.636301590031323	0.620375967570286	0.703573328621418	0.64731753285226	0.657467296685633	NA	NA	0.602001472143334	0.625285647210386	NA	NA	p.Lys50Trp	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.382	-5.91	3.528	0.008175962	NA	NA	NA	NA	NA	NA	NA
K50X	50	K	X	nonsense	low	0.393238291270379	0.142851337582717	6	0.0583188143586204	0.278935515506406	0.507541067034353	0.327127865955576	0.456749734456805	0.227600946190338	0.327483590589785	NA	NA	0.378908026744144	0.641559583685627	0.549520264688281	0.542958246919078	0.556082282457485	0.486622832217717	0.501596194484006	NA	NA	0.563675022639991	0.615946053430324	NA	NA	p.Lys50Ter	1	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K50Y	50	K	Y	missense	wt-like	0.978757578348182	0.165110832269566	6	0.0674062150111159	0.846643824592232	1.11087133210413	0.879216697730597	0.701460575938721	1.10324682163783	1.1394646114087	NA	NA	1.06920183962774	0.979954923745514	0.698861814055688	0.660552488937782	0.608991646524002	0.748629215422181	0.770527452994234	NA	NA	0.705671962789369	0.692051665322008	NA	NA	p.Lys50Tyr	0	29.5	17.8	30.8	0.943	109.1	49.3	-56.1	-47.1	56.5217391304348	-3.4	1	0	16.59	0	0	0	0	7	20.6004077455033	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.382	-3.918	1.536	0.008175962	NA	NA	NA	NA	NA	NA	NA
K51A	51	K	A	missense	wt-like	0.942211390505083	0.164248152826072	6	0.0670540276030913	0.810787911384669	1.0736348696255	0.71921504651221	0.746235436603193	1.02609789195391	1.03584365899621	NA	NA	1.03294244909897	1.09293385986601	0.707837008560927	0.626472334053514	0.618672498379923	0.725545098199281	0.73620779228072	NA	NA	0.698213222162303	0.717460794959551	NA	NA	p.Lys51Ala	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.88	-2.561	0.681	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51C	51	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Cys	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.88	-4.437	2.557	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51D	51	K	D	missense	possibly_low	0.111714817972147	1.15285110762683	4	0.576425553813417	-1.01805850727071	1.241488143215	0.874994242922151	1.31852367682943	NA	NA	NA	NA	-0.934932910285903	-0.811725737577094	0.476532193086434	0.659653111257815	0.742407951495734	NA	NA	NA	NA	0.293411274915052	0.289100037736585	NA	NA	p.Lys51Asp	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.88	-3.003	1.123	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51E	51	K	E	missense	wt-like	1.13523627292483	0.275184621527594	6	0.112343651300585	0.915046762483958	1.35542578336571	0.689559428412588	0.970643776335945	1.12273607567414	1.25078844962569	NA	NA	1.46223110199022	1.31545880551041	0.760983838298863	0.620155723879008	0.667192222616824	0.754460692626135	0.807398339315804	NA	NA	0.786520076452022	0.76750698397159	NA	NA	p.Lys51Glu	1	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.88	-2.362	0.482	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51F	51	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Phe	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.88	-4.83	2.95	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51G	51	K	G	missense	possibly_wt-like	0.752449239568622	0.0919319278337885	6	0.0375310523771914	0.67888972860744	0.826008750529803	0.782050283092734	0.865754331459119	0.69625082238537	0.749863062653592	NA	NA	0.814887186339184	0.60588975148173	0.640673036727188	0.639856162148707	0.644513890132185	0.62684990630555	0.641489911305669	NA	NA	0.653358148109106	0.607923855472543	NA	NA	p.Lys51Gly	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.88	-3.175	1.295	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51H	51	K	H	missense	wt-like	1.15193943020542	0.21210582889226	6	0.086591842042686	0.982222538446773	1.32165632196406	1.0174277321221	0.970645400933604	0.940856330403815	1.17114359973572	NA	NA	1.41544510046085	1.39611841757642	0.738467751317194	0.689991269243544	0.667192573873959	0.700039544108677	0.781019656605749	NA	NA	0.776895958525712	0.785647449883867	NA	NA	p.Lys51His	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.88	-3.627	1.747	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51I	51	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Ile	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.88	-4.439	2.559	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51L	51	K	L	missense	wt-like	1.29841934761627	0.250715979560476	2	0.17728296929904	0.950951112717832	1.64588758251471	1.12113637831723	1.47570231691531	NA	NA	NA	NA	NA	NA	0.744236453355821	0.712081083306424	0.776391823405219	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Leu	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.88	-3.357	1.477	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51M	51	K	M	missense	low	0.58809113261452	0.142719124422069	6	0.0582648385618092	0.473894147468333	0.702288117760707	0.676423253250879	0.807133815571097	0.46324338701723	0.439236625325774	NA	NA	0.633504104765051	0.509005609757089	0.601090598343635	0.617357734728966	0.631839444659708	0.557130585844689	0.538609232354739	NA	NA	0.616046727815766	0.586134468871505	NA	NA	p.Lys51Met	1	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.88	-4.292	2.412	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51N	51	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Asn	1	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.88	-2.762	0.882	0.008335198	NA	NA	NA	NA	4.07e-06	NA	NA
K51P	51	K	P	missense	wt-like	0.837025633975077	0.0386388264796125	6	0.0157742348558316	0.80610870177397	0.867942566176183	0.82001186319854	0.782637511750639	0.868753612879762	0.822403751908694	NA	NA	0.836580258397217	0.891766805715608	0.661668095806792	0.647941932012991	0.626543055463088	0.678465329272073	0.66551566850243	NA	NA	0.657820523111154	0.672218027296573	NA	NA	p.Lys51Pro	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.88	-3.396	1.516	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51Q	51	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Gln	1	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.88	-2.47	0.59	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51R	51	K	R	missense	wt-like	1.15988577749545	0.242181253287533	6	0.0988700826370312	0.966103976378372	1.35366757861253	0.911123950232032	0.969230198638558	1.27206030788311	1.00863413806731	NA	NA	1.54927982416911	1.2489862459826	0.739876550356649	0.667348694470037	0.666886590481467	0.799140743206926	0.727195893579578	NA	NA	0.804426440325807	0.752557207133721	NA	NA	p.Lys51Arg	1	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.88	-2.174	0.294	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51S	51	K	S	missense	wt-like	0.957812340581894	0.0876039648655762	6	0.0357641688942278	0.8877158576122	1.02790882355159	0.961514298366618	0.976674847978591	0.796293164536222	0.954028522823492	NA	NA	0.999916699800823	1.05844650998562	0.684750717290244	0.678081776635264	0.668496211289004	0.656784076007261	0.709110302349336	NA	NA	0.691419657945224	0.709704539023209	NA	NA	p.Lys51Ser	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.88	-2.893	1.013	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51T	51	K	T	missense	wt-like	1.13903086358397	0.168703575000124	6	0.0688729460889427	1.00404236974047	1.27401935742747	0.917820089757901	0.986305545788911	1.20398473030093	1.15962204166121	NA	NA	1.39235372677928	1.17409904721558	0.753930455642061	0.668774963951824	0.67057848150464	0.778771509059907	0.777203671953975	NA	NA	0.772145945784134	0.735714965499988	NA	NA	p.Lys51Thr	1	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.88	-2.832	0.952	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51V	51	K	V	missense	wt-like	0.990880117289189	0.282263686360828	6	0.115233667416836	0.765026279345723	1.21673395523265	0.944573518885352	0.84153448759712	1.37449804385435	1.30668854766044	NA	NA	0.731129837688585	0.746856268049278	0.657050422372058	0.674473411445371	0.639277274832395	0.82979165067767	0.825912668259317	NA	NA	0.636128836471895	0.639627433298744	NA	NA	p.Lys51Val	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.88	-3.313	1.433	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51W	51	K	W	missense	possibly_wt-like	0.789467535406589	0.104368459713494	6	0.0426082452563804	0.705956909259634	0.872978161553544	0.74608988388457	0.863794799928308	0.851266683288573	0.594804796133844	NA	NA	0.849135660467593	0.831713388736648	0.65140107072668	0.632196641353877	0.644090216352406	0.673232977582873	0.590134012967658	NA	NA	0.660403233028387	0.658711925100953	NA	NA	p.Lys51Trp	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.88	-5.923	4.043	0.008335198	NA	NA	NA	NA	NA	NA	NA
K51X	51	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Ter	1	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K51Y	51	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys51Tyr	0	33.2	18.5	31.6	0.884	122.3	30.9	-55.6	-45.7	60.4347826086956	-2.8	1	0	17.8	1	167	1	167	6	23.3741208723177	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.88	-4.742	2.862	0.008335198	NA	NA	NA	NA	NA	NA	NA
H52A	52	H	A	missense	possibly_low	0.486111484982344	0.519840249880843	6	0.212223893328161	0.070160297400278	0.902062672564411	1.08313962134479	1.07446751381725	-0.190992161493653	0.0577180767057772	NA	NA	0.487294436860455	0.40504142265945	0.57436171340278	0.703987820812818	0.689640136619649	0.361373494267541	0.412248811612523	NA	NA	0.585970657198847	0.562752769606713	NA	NA	p.His52Ala	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.564	-3.75	2.186	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52C	52	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His52Cys	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.564	-3.84	2.276	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52D	52	H	D	missense	wt-like	1.01393540164213	0.153190791155247	6	0.0625398786039364	0.891359491980911	1.13651131130336	1.06609781834598	1.04464917808318	0.975957959465344	1.15672359999728	NA	NA	0.72744083365729	1.11274302030372	0.705450207944903	0.700357937737964	0.68319306148535	0.710542478151843	0.7762436968506	NA	NA	0.63536998962311	0.72191590440611	NA	NA	p.His52Asp	1	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.564	-4.092	2.528	0.007008625	NA	NA	NA	NA	4.07e-06	NA	NA
H52E	52	H	E	missense	wt-like	1.09666372706706	0.339465870481646	6	0.138586361294959	0.825039450180486	1.36828800395364	0.572848448211082	0.952991113925014	1.40271880883913	1.34412191414402	NA	NA	1.39835570266369	0.90894637461942	0.724731160201274	0.595296428667529	0.66337550923957	0.83823572695582	0.838310744200242	NA	NA	0.773380582680092	0.676081737722457	NA	NA	p.His52Glu	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.564	-3.941	2.377	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52F	52	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His52Phe	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.564	-2.326	0.762	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52G	52	H	G	missense	wt-like	0.84242497806908	0.091789213771888	6	0.0374727896053954	0.768979660042259	0.915870296095902	0.81381676841207	0.872246844216596	0.946845686118074	0.937766648749002	NA	NA	0.752640316481115	0.731233604437626	0.646270016124344	0.646622384444339	0.645917647804348	0.701831649196382	0.703724306681387	NA	NA	0.640553651112675	0.636113873173087	NA	NA	p.His52Gly	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.564	-3.237	1.673	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52I	52	H	I	missense	wt-like	1.00917910541776	0.176867011514025	6	0.0722056550900532	0.867658621961131	1.15069958887438	0.952540779950645	1.15061736077141	0.762568535628421	0.871228960242621	NA	NA	1.09416828514875	1.22395071076469	0.69389569818022	0.676170428251392	0.706104629781081	0.646693161069153	0.681686766579359	NA	NA	0.710807687323216	0.74692667827816	NA	NA	p.His52Ile	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.564	-4.222	2.658	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52K	52	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His52Lys	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.564	-4.022	2.458	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52L	52	H	L	missense	wt-like	1.27087593209096	0.175096594561212	2	0.123811989376904	1.02820889205797	1.51354297212395	NA	NA	1.39468792146787	1.14706394271406	NA	NA	NA	NA	0.804438572959247	NA	NA	0.835832764967341	0.773044380951153	NA	NA	NA	NA	NA	NA	p.His52Leu	1	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.564	-3.231	1.667	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52M	52	H	M	missense	possibly_low	0.436328691389333	0.544046087978213	3	0.314105155345784	-0.179306100446763	1.05196348322543	0.898482368766578	0.573757795270724	NA	NA	NA	NA	-0.163254089869304	NA	0.581380802338462	0.664656053168875	0.581380802338462	NA	NA	NA	NA	0.452149524095501	NA	NA	NA	p.His52Met	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.564	-5.02	3.456	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52N	52	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His52Asn	1	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.564	-2.396	0.832	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52P	52	H	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His52Pro	1	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.564	-4.503	2.939	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52Q	52	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His52Gln	1	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.564	-3.516	1.952	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52R	52	H	R	missense	wt-like	1.25978968566564	0.117081205885654	6	0.047798202148266	1.16610693092927	1.35347244040201	1.2261420686874	1.46487069887229	1.21038508560629	1.29885012351385	NA	NA	1.11440581826821	1.24408431904582	0.762752328312493	0.734447166183033	0.774049900100974	0.780686591391477	0.823316551827488	NA	NA	0.714970650579588	0.751454756524011	NA	NA	p.His52Arg	1	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.564	-3.452	1.888	0.007008625	NA	NA	NA	NA	2.03e-05	NA	NA
H52S	52	H	S	missense	wt-like	0.910595889398534	0.0896341295722766	6	0.0365929801650983	0.838874966187952	0.982316812609115	0.866808738145542	1.06732675204404	0.896861925807759	0.862836698155608	NA	NA	0.955213933514522	0.814527288723732	0.680565644478266	0.657909608809756	0.68809621988068	0.68687575820772	0.678907216876914	NA	NA	0.682224072079619	0.654846745818983	NA	NA	p.His52Ser	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.564	-3.461	1.897	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52T	52	H	T	missense	wt-like	0.954658981571099	0.175742762897216	6	0.0717466825141844	0.814038067833068	1.09527989530913	1.09567077780168	1.15744357572731	0.856679772423802	0.899536909181067	NA	NA	1.0362308928521	0.682391961440634	0.694976070310105	0.706656941722996	0.70758053779607	0.674852655064435	0.691062468890949	NA	NA	0.69888967172926	0.625129315509191	NA	NA	p.His52Thr	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.564	-4.051	2.487	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52V	52	H	V	missense	possibly_wt-like	0.736655940186863	0.173482976245003	6	0.0708241284766054	0.597843199136279	0.875468681237447	0.901179084774074	0.992331954422512	0.726629245709158	0.598740798283893	NA	NA	0.631027115800334	0.570027442131207	0.625738392473208	0.66523045036112	0.671881461979382	0.635939586329969	0.591437632122012	NA	NA	0.615537198616447	0.599858369120138	NA	NA	p.His52Val	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.564	-4.007	2.443	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52W	52	H	W	missense	possibly_wt-like	0.852866777837494	0.25150622812085	6	0.102676987671351	0.651623579960583	1.05410997571441	1.0785230501293	0.737625203584217	0.940854220928805	1.14938543766768	NA	NA	0.475142923395538	0.735669831319434	0.668575250037279	0.703004496822971	0.616810864662594	0.700038912922105	0.773813269069834	NA	NA	0.583471029217257	0.637111587152453	NA	NA	p.His52Trp	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.564	-3.77	2.206	0.007008625	NA	NA	NA	NA	NA	NA	NA
H52X	52	H	X	nonsense	low	0.484669320279785	0.222501999208078	6	0.0908360608014897	0.306633912611375	0.662704727948196	0.454295384118494	0.910176271621698	0.365970279303903	0.48924691845874	NA	NA	0.266824061697449	0.421503006478428	0.560813919616357	0.570044771853279	0.654118436421878	0.528025012633369	0.555172835106377	NA	NA	0.540618782269017	0.566455004126337	NA	NA	p.His52Ter	0	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H52Y	52	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His52Tyr	1	33.5	21.5	29.2	0.442	88	103.8	-98.5	-0.7	12.037037037037	-5.1	1	0	17.39	0	0	0	0	7	23.0570249442766	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.564	-1.637	0.073	0.007008625	NA	NA	NA	NA	NA	NA	NA
L53A	53	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu53Ala	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.96	-2.878	0.918	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53C	53	L	C	missense	possibly_low	0.719522432443279	0.428748022785574	6	0.175035647341972	0.37645886764236	1.0625859972442	1.27225326597738	1.16291669115726	0.296275296331565	0.537609103829953	NA	NA	0.777375099361284	0.270705138002223	0.608416149825368	0.744268794482336	0.708763889768169	0.507171228097757	0.571190578184988	NA	NA	0.645641721465749	0.532540340732	NA	NA	p.Leu53Cys	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.96	-3.911	1.951	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53D	53	L	D	missense	possibly_low	0.614591445400515	0.177564774143479	6	0.0724905154906771	0.472512645818045	0.756670244982985	0.539613085587859	0.500569000743039	0.517714884664023	0.464560729384626	NA	NA	0.75469575463349	0.910395217390054	0.580823306243411	0.588217337313101	0.565556523561908	0.573429275173721	0.546996673687201	NA	NA	0.640976465170771	0.676407584601951	NA	NA	p.Leu53Asp	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.96	-4.358	2.398	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53E	53	L	E	missense	possibly_wt-like	0.769167589449699	0.274564529165411	6	0.112090499653795	0.549474247119162	0.988860931780236	1.04439085626491	1.06454519744463	0.804691491602983	0.73151363956168	NA	NA	0.6425286817324	0.327335670091584	0.647354746392189	0.695734381517409	0.687494815038624	0.65929698146531	0.635412511319068	NA	NA	0.617903129092424	0.545276631059313	NA	NA	p.Leu53Glu	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.96	-3.224	1.264	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53F	53	L	F	missense	wt-like	1.0876599171892	0.14603892140108	6	0.0596201400031774	0.970806590029739	1.20451324434867	1.03631697924765	1.09473132914396	0.998233701241222	0.888343592299072	NA	NA	1.2344501955652	1.27388370563811	0.705614563141208	0.694014655644771	0.694021411989407	0.717207714293008	0.687355198993258	NA	NA	0.739664388144907	0.75815668259132	NA	NA	p.Leu53Phe	1	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.96	-2.14	0.18	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53G	53	L	G	missense	wt-like	0.805093452592857	0.0953755264570046	6	0.0389368956281631	0.728778539491862	0.881408365693852	0.759190593446918	0.940448111351082	0.884600468608115	0.782359975838636	NA	NA	0.670639941606163	0.793321624706227	0.651165287725931	0.634987076374883	0.660663564457506	0.683206946255567	0.652253014797592	NA	NA	0.623685757896735	0.65007756065427	NA	NA	p.Leu53Gly	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.96	-4.023	2.063	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53H	53	L	H	missense	possibly_wt-like	0.784705328529748	0.112672741593446	6	0.0459984541374008	0.694550015075925	0.874860641983571	0.877290844160738	0.931934914870714	0.657821972932065	0.822175605542687	NA	NA	0.662529255444535	0.756479378227751	0.650307298088013	0.660142284496482	0.658822911181901	0.615351418003045	0.665440105542507	NA	NA	0.622017348596277	0.641791684994125	NA	NA	p.Leu53His	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.96	-4.137	2.177	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53I	53	L	I	missense	wt-like	1.00793935257549	0.189831412183524	6	0.0774983495002647	0.85604537869367	1.1598333264573	1.17530559781385	1.26517210343927	0.902534608641857	1.04117658861542	NA	NA	0.755301012820111	0.908146204122411	0.706096085220929	0.723619060423204	0.730872713404412	0.688573110018654	0.737974079222493	NA	NA	0.641100969851092	0.675901778195586	NA	NA	p.Leu53Ile	1	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.96	-2.678	0.718	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53K	53	L	K	missense	possibly_low	0.604458538503527	0.160917721093431	6	0.065694384541734	0.475699910815203	0.73321716619185	0.901430593903545	0.669016521663842	0.554273837759493	0.501109319637685	NA	NA	0.534236742536146	0.46668421552045	0.589997595056605	0.665284021496304	0.601976860137636	0.584368262432001	0.559101708314262	NA	NA	0.595626927681209	0.576616324786192	NA	NA	p.Leu53Lys	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.96	-4.206	2.246	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53L	53	L	L	synonymous	wt-like	1.0975869734582	0.17149873696308	6	0.070014066181889	0.960361925330494	1.23481202158591	0.86011165086333	0.974380239046877	1.06288826737434	1.31574088289082	NA	NA	1.11208950898026	1.26031129159357	0.725523752247172	0.656483137457034	0.668000089831438	0.736553330489208	0.82891083674299	NA	NA	0.714494174005136	0.755104226622145	NA	NA	p.Leu53=	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53M	53	L	M	missense	wt-like	1.13537286462989	0.142066641297591	6	0.0579984634416843	1.02169796512553	1.24904776413426	0.933056615585	1.00681458792841	1.18020934204279	1.2933426106769	NA	NA	1.13502509939275	1.2637889321535	0.737549247229677	0.672020325209859	0.675012777797533	0.771657556192129	0.821492442247923	NA	NA	0.719212141337755	0.755886353121598	NA	NA	p.Leu53Met	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.96	-3.784	1.824	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53N	53	L	N	missense	low	0.344138035212483	0.331095253052236	6	0.135169071039275	0.0792115241517674	0.609064546273199	0.760677717590727	0.763504454346598	0.129524033209831	0.227971579475533	NA	NA	0.0153615033292046	0.167788923323006	0.499142994999433	0.635303831988136	0.62240626326473	0.457276748411007	0.468637431040435	NA	NA	0.488891657986583	0.509394332012283	NA	NA	p.Leu53Asn	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.96	-4.516	2.556	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53P	53	L	P	missense	low	0.339492623865252	0.104231219661399	6	0.0425522172397294	0.256091810613058	0.422893437117446	0.219146227432345	0.433886043458563	0.195575575046228	0.415571884399832	NA	NA	0.382590748991517	0.390185263863024	0.540955130942988	0.519958290746714	0.551138883368157	0.477040360696383	0.530771378517819	NA	NA	0.564432577293947	0.559411597546359	NA	NA	p.Leu53Pro	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.96	-3.654	1.694	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53Q	53	L	Q	missense	possibly_low	0.676235960814868	0.230907053325839	6	0.0942674097763217	0.491475232737399	0.860996688892338	0.685249217488301	0.943751918561811	0.46041839434899	0.393372078366981	NA	NA	0.639529629342114	0.935094526781015	0.618261931525808	0.61923765425432	0.661377886460811	0.55628530565513	0.523418716790483	NA	NA	0.617286208797297	0.681962495772325	NA	NA	p.Leu53Gln	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.96	-3.509	1.549	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53R	53	L	R	missense	possibly_low	0.668870725095253	0.125692698473782	6	0.0513138292757115	0.568297467806022	0.769443982384485	0.745223855034048	0.875649116451074	0.680325977011258	0.590402901808352	NA	NA	0.58035666288223	0.541265837384555	0.613599491489057	0.632012178274057	0.646653259104679	0.62208495364997	0.588676088520619	NA	NA	0.605114029328144	0.593389841723031	NA	NA	p.Leu53Arg	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.96	-4.5	2.54	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53S	53	L	S	missense	wt-like	0.904577650955193	0.0900963183570774	6	0.0367816679463648	0.832486906489007	0.976668395421379	0.861147413418183	0.975338327676303	0.995546255664275	0.975698224354646	NA	NA	0.775081671968349	0.844654012649401	0.664914765202772	0.65670375360708	0.668207239869398	0.716403590256776	0.716287391412867	NA	NA	0.645169951813214	0.661622290536145	NA	NA	p.Leu53Ser	1	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.96	-3.038	1.078	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53T	53	L	T	missense	possibly_wt-like	0.728252305968633	0.0863395986201476	6	0.0352479935360114	0.65916750811075	0.797337103826516	0.661477512327168	0.841678515621085	0.749318639803246	0.642830806829703	NA	NA	0.81472801407373	0.659480347156867	0.629642437497857	0.614174310297645	0.639308415386322	0.642728593450747	0.606040413691947	NA	NA	0.653325405566395	0.619976459609392	NA	NA	p.Leu53Thr	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.96	-3.401	1.441	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53V	53	L	V	missense	wt-like	0.885671211227261	0.134104125921919	6	0.0547477801517742	0.778367533896267	0.992974888558256	0.840397806193385	0.746918587739693	0.93546748947368	1.05740929309517	NA	NA	1.00097027302729	0.732863817834352	0.671960248048702	0.652284112793226	0.61882020369602	0.698427122053873	0.743350413807705	NA	NA	0.691636383304179	0.636480510574328	NA	NA	p.Leu53Val	1	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.96	-2.719	0.759	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53W	53	L	W	missense	wt-like	1.03279767799996	0.188591143686446	6	0.0769920120066164	0.881896107369721	1.18369924863021	0.948398714350193	0.731687183945607	1.26023475028708	1.17560210745918	NA	NA	1.10290205107415	0.977961260883573	0.702103777445983	0.675288173373837	0.615526994928868	0.795602358955956	0.78249633162943	NA	NA	0.71260426729285	0.691603287599115	NA	NA	p.Leu53Trp	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.96	-1.965	0.005	0.007678952	NA	NA	NA	NA	NA	NA	NA
L53X	53	L	X	nonsense	low	0.544283564313728	0.0826028610766965	6	0.0337224768219853	0.47818872427315	0.610378404354306	0.631555462442417	0.650460066230404	0.497306869237971	0.467746749613826	NA	NA	0.557876345727296	0.460755892630452	0.586623886140989	0.607800950480657	0.597964736071672	0.567322890777828	0.548051895925048	NA	NA	0.600489714014852	0.575283036210306	NA	NA	p.Leu53Ter	1	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L53Y	53	L	Y	missense	possibly_wt-like	0.843679815038921	0.449035169287904	6	0.183317840219938	0.484383450484174	1.20297617959367	1.14924286975891	-0.00787629795034417	1.1091154073696	1.00232311318806	NA	NA	0.696561142981143	1.11271265488616	0.71998840329364	0.718067731408438	0.455624665808621	0.750385184319221	0.725105657699983	NA	NA	0.629017880554574	0.721909075178843	NA	NA	p.Leu53Tyr	0	29.9	22.9	29.3	0.87	81.8	47.2	-54.6	-48.3	2.09424083769634	-4.4	1	0	17.96	0	0	0	0	8	21.9745129061558	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.96	-2.84	0.88	0.007678952	NA	NA	NA	NA	NA	NA	NA
D54A	54	D	A	missense	wt-like	0.890870604788075	0.171183643604251	6	0.0698854298568107	0.753897679224626	1.02784353035152	0.786383277475948	0.978798132566681	0.913582350628578	0.77234247394953	NA	NA	1.17835007481566	0.715767319292051	0.658945234892992	0.64077908462212	0.668955290407068	0.691878760169793	0.648935179378916	NA	NA	0.728124308631274	0.632635482795468	NA	NA	p.Asp54Ala	1	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.067	-2.68	0.613	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54C	54	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54Cys	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.067	-4.094	2.027	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54E	54	D	E	missense	possibly_low	0.606220400123089	0.192522623369808	6	0.0785970318663424	0.452173048373311	0.760267751872867	0.981054441570394	0.56413455652756	0.621492778622283	0.451286351107661	NA	NA	0.500349299661329	0.519004973249307	0.588519724607901	0.682243803100457	0.579300144860935	0.604481178020502	0.542600148196538	NA	NA	0.588656108722815	0.588383340492988	NA	NA	p.Asp54Glu	1	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.067	-2.491	0.424	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54F	54	D	F	missense	possibly_low	0.599851158368414	0.311270557864426	6	0.127075673119885	0.350787415742255	0.848914900994573	1.02900562990173	0.887375165790923	0.236077015690008	0.554716045495889	NA	NA	0.312038519442821	0.579894573889113	0.589466982570497	0.692457347228111	0.649188568982357	0.489158999378058	0.576856463511767	NA	NA	0.54991962566429	0.602077501629227	NA	NA	p.Asp54Phe	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.067	-4.085	2.018	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54G	54	D	G	missense	wt-like	0.875256229381017	0.168021307555096	6	0.068594411570871	0.740813653161392	1.00969880560064	0.929128850699212	1.10470443725377	0.705586967822056	1.02313314857564	NA	NA	0.763898728089267	0.725085243846155	0.657026639815632	0.671183716120906	0.696177715341809	0.629643421089922	0.731998022007687	NA	NA	0.642869563510357	0.634731097793077	NA	NA	p.Asp54Gly	1	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.067	-2.808	0.741	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54H	54	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54His	1	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.067	-2.885	0.818	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54I	54	D	I	missense	possibly_low	0.495432502706082	0.3437759745383	6	0.140345953907809	0.220359487670857	0.770505517741307	0.683424642727384	1.05119737187077	0.109386387103931	0.556395107846769	NA	NA	0.229961196352622	0.342230310335021	0.563019516559267	0.618849022074736	0.684608858051564	0.45125126257204	0.577412575464586	NA	NA	0.533035903810005	0.548626457653948	NA	NA	p.Asp54Ile	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.067	-4.542	2.475	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54K	54	D	K	missense	possibly_low	0.412509607456754	0.476486214586991	5	0.213091113231613	-0.00514129990275419	0.830160514816261	0.699275689797134	0.773091584477853	NA	-0.391869547400754	NA	NA	0.355845468515442	0.626204841894092	0.612492749317813	0.622225275601505	0.62447911363538	NA	0.263343649470122	NA	NA	0.558930937383291	0.612492749317813	NA	NA	p.Asp54Lys	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.067	-2.774	0.707	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54L	54	D	L	missense	wt-like	0.819380848283156	0.0340560187399947	6	0.0139033114306081	0.79213085861332	0.846630837952992	0.79764606975016	0.818608929076344	0.869050295420008	0.847441645224787	NA	NA	0.808303633861548	0.775234516366088	0.649006810612603	0.643178045521658	0.634320499256542	0.678554101139227	0.673808315728533	NA	NA	0.65200387795676	0.646009743268446	NA	NA	p.Asp54Leu	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.067	-4.095	2.028	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54M	54	D	M	missense	low	0.319232754000381	0.257069415786431	5	0.114964937726923	0.0939056165707214	0.544559891430041	0.228434605596804	0.776649668058652	0.22749514565258	0.200075870329566	NA	NA	NA	0.163508480364306	0.508431654067363	0.521936703869691	0.625248413182615	0.486591175109499	0.459398264144522	NA	NA	NA	0.508431654067363	NA	NA	p.Asp54Met	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.067	-5.231	3.164	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54N	54	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54Asn	1	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.067	-3.006	0.939	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54P	54	D	P	missense	wt-like	1.12149988726278	0.155921543041455	6	0.0636547033931614	0.996738961165607	1.24626081335996	0.906705212934425	1.26255327136939	1.2065532881466	1.04766744851358	NA	NA	1.29573753713676	1.00978256547594	0.735215184122589	0.666407508861335	0.730306491088411	0.779540060103274	0.740123877156768	NA	NA	0.752271505303755	0.698759946011625	NA	NA	p.Asp54Pro	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.067	-2.106	0.039	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54Q	54	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54Gln	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.067	-2.702	0.635	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54R	54	D	R	missense	low	0.553189609620192	0.134115059502785	4	0.0670575297513927	0.421759266415239	0.684619952825145	NA	NA	0.695613297546297	0.382586418219465	NA	NA	0.521598131351716	0.612960591363289	0.601270599517326	NA	NA	0.626659149308947	0.519846464381912	NA	NA	0.593027101226978	0.609514097807673	NA	NA	p.Asp54Arg	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.067	-3.343	1.276	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54S	54	D	S	missense	wt-like	1.09994731175269	0.1195448453087	6	0.0488039787310436	1.00429327113758	1.19560135236779	0.899055830895621	1.0783500071026	1.16360459247277	1.14628160782618	NA	NA	1.2513381574769	1.06105367474205	0.726714610917609	0.66477819989692	0.690479577363167	0.766689166000566	0.77278526860668	NA	NA	0.743138327606718	0.7102908942285	NA	NA	p.Asp54Ser	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.067	-2.432	0.365	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54T	54	D	T	missense	wt-like	1.30619173937227	0.120486351744886	2	0.0851967163592365	1.13920924370709	1.47317423503745	1.3913884557315	1.22099502301303	NA	NA	NA	NA	NA	NA	0.745482776009	0.769644443346393	0.721321108671606	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54Thr	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.067	-3.216	1.149	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54V	54	D	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54Val	1	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.067	-4.164	2.097	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54W	54	D	W	missense	possibly_wt-like	0.798343730406199	0.181381127843064	6	0.0740485353643382	0.653211267984155	0.943476192828242	0.90250246577879	0.834270916565324	0.523030194774117	0.752302016459458	NA	NA	0.71867117811514	1.05928561074436	0.640002253768692	0.665512328887174	0.637706805286309	0.575019695703989	0.642297702251076	NA	NA	0.633566026977193	0.709893254023456	NA	NA	p.Asp54Trp	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.067	-3.706	1.639	0.008338073	NA	NA	NA	NA	NA	NA	NA
D54X	54	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54Ter	0	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D54Y	54	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp54Tyr	1	30.6	25.9	31.6	0.9	112.4	50.4	-61.3	-40.2	63.6363636363636	-1.7	1	0	19.69	0	0	0	0	7	25.603428733616	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.067	-4.662	2.595	0.008338073	NA	NA	NA	NA	NA	NA	NA
T55A	55	T	A	missense	wt-like	0.984295719537298	0.101559867629344	6	0.0414616423394159	0.903032393812162	1.06555904526243	0.841645037522684	0.960401836381628	1.12612125074751	1.01352940227377	NA	NA	1.05158197248294	0.912494817815261	0.68946362727322	0.652549771532091	0.664977794655608	0.755473587795697	0.728817224041779	NA	NA	0.702047466707116	0.676879787839325	NA	NA	p.Thr55Ala	1	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.32	-2.315	-0.005	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55C	55	T	C	missense	possibly_wt-like	0.877089910840554	0.213841771182208	6	0.0873005375149011	0.70598400148036	1.04819582020075	1.22348391134748	0.861648794421693	0.764793634798681	1.03363851181009	NA	NA	0.668193042626204	0.710781570039174	0.645492584414143	0.733880981939551	0.643626224704342	0.647358944123944	0.735477438993194	NA	NA	0.623182418359969	0.631514180423037	NA	NA	p.Thr55Cys	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.32	-4	1.68	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55D	55	T	D	missense	possibly_wt-like	0.920715634712448	0.45365175431977	6	0.185202553166979	0.557725300660305	1.28370596876459	0.0959308748665412	1.42984199133133	0.864003757515958	1.20778890656073	NA	NA	0.952074018359309	0.97465425964081	0.686218856866564	0.493713572222961	0.76647628125826	0.677044101285384	0.793156724135979	NA	NA	0.68157817559895	0.690859538134177	NA	NA	p.Thr55Asp	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.32	-3.261	0.941	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55E	55	T	E	missense	possibly_low	0.603822444793646	0.523492499343474	6	0.213714917927628	0.184948902696561	1.02269598689073	1.21021101878113	1.21652769600353	0.130195056998095	0.724375931043293	NA	NA	0.0894003916546318	0.252224574281189	0.5807162546333	0.731053872150502	0.720355219993694	0.457477528795791	0.63304847461684	NA	NA	0.504121833019377	0.52838403464976	NA	NA	p.Thr55Glu	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.32	-2.743	0.423	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55F	55	T	F	missense	wt-like	0.865833266595951	0.140016088449974	6	0.0571613287471389	0.753799120943105	0.977867412248797	1.02844382292354	0.969850384278917	0.868029488570507	0.815516016928742	NA	NA	0.62552357183239	0.887636315041607	0.669154877879114	0.692337683032862	0.667020681916222	0.678248660414743	0.66323442400416	NA	NA	0.614405091694959	0.671289073842007	NA	NA	p.Thr55Phe	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.32	-3.95	1.63	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55G	55	T	G	missense	possibly_wt-like	0.795325377194446	0.254735789675196	6	0.103995450654861	0.591498039354906	0.999152715033986	1.17440592740174	1.05639144802908	0.585751060896687	0.58475465100734	NA	NA	0.693457353690767	0.677191822141069	0.626169605923081	0.723427431732148	0.685731878448965	0.593786719845829	0.586805365982344	NA	NA	0.62837941534762	0.623959796498541	NA	NA	p.Thr55Gly	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.32	-2.978	0.658	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55H	55	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr55His	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.32	-4.367	2.047	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55I	55	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr55Ile	1	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.32	-3.592	1.272	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55K	55	T	K	missense	wt-like	0.977999251448595	0.100977828572019	6	0.0412240258892799	0.89720164540786	1.05879685748933	0.989200270328727	0.887289287929808	1.02231275975365	1.06457124251827	NA	NA	0.826115337932308	1.07850661022881	0.699097469904083	0.68397885460543	0.649170001178039	0.724412529856818	0.745722479191446	NA	NA	0.655667835868144	0.714216085202736	NA	NA	p.Thr55Lys	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.32	-2.603	0.283	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55L	55	T	L	missense	wt-like	0.974190226028271	0.146731242731428	6	0.0599027790027435	0.856782936609032	1.09159751544751	0.784686707947222	0.922646835496133	0.916555428935528	1.2149958456953	NA	NA	0.947910307621358	1.05834623047408	0.68674501448796	0.640417717399528	0.65681471910454	0.692768349804175	0.795543690286384	NA	NA	0.680721679171745	0.709681986012922	NA	NA	p.Thr55Leu	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.32	-2.889	0.569	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55M	55	T	M	missense	wt-like	0.961267451600013	0.215613875561019	6	0.0880239960980742	0.788743589472493	1.13379131372753	0.919210400440189	1.03170831755979	1.1686650274781	1.04454272972436	NA	NA	1.05160798294879	0.551870251448846	0.691223956161965	0.669071098416868	0.680395095132001	0.768203324075611	0.739088958193233	NA	NA	0.702052817191929	0.595774790112015	NA	NA	p.Thr55Met	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.32	-4.348	2.028	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55N	55	T	N	missense	possibly_wt-like	0.858545856607416	0.344719595991934	6	0.1407311857531	0.582717801029722	1.13437391218511	1.15792835541329	1.23965399162493	0.954920198580432	0.901298049433733	NA	NA	0.370370210325877	0.52710433426623	0.697946714914654	0.719917729168414	0.725355397293288	0.70424766446662	0.691645765362688	NA	NA	0.561918750478306	0.590204898750898	NA	NA	p.Thr55Asn	1	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.32	-3.56	1.24	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55P	55	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr55Pro	1	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.32	-3.025	0.705	0.008346654	NA	NA	NA	NA	4.06e-06	NA	NA
T55Q	55	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr55Gln	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.32	-2.604	0.284	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55R	55	T	R	missense	low	0.418056207043277	0.293794547902427	6	0.119941121928769	0.182975927797562	0.653136486288993	0.435489269436228	0.904239279364399	0.407179497667574	0.278281964393745	NA	NA	0.479219295861135	0.00392793553658404	0.553197260793898	0.566039092560206	0.652834788820083	0.540355429027589	0.485300425353459	NA	NA	0.584309559718647	0.472541753786902	NA	NA	p.Thr55Arg	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.32	-2.577	0.257	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55S	55	T	S	missense	wt-like	1.04800813396113	0.164311733894902	6	0.0670799844657471	0.916533780324758	1.1794824875975	0.884864171267577	0.820085102480006	1.20004088177188	1.22336669645848	NA	NA	1.09620125682874	1.06349069496008	0.711032431794845	0.661755393853947	0.63463966532032	0.777591450410657	0.79831614847546	NA	NA	0.711225879913938	0.710838983675752	NA	NA	p.Thr55Ser	1	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.32	-2.385	0.065	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55T	55	T	T	synonymous	wt-like	1.03350271871769	0.0665818546108578	2	0.0470804808993144	0.941226671780203	1.12577876565517	0.986422237818371	1.080583199617	NA	NA	NA	NA	NA	NA	0.687174778483286	0.683387137098107	0.690962419868466	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr55=	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55V	55	T	V	missense	wt-like	0.938648985148438	0.210858912896301	6	0.0860827907189836	0.769929815650532	1.10736815464634	0.633545420533472	0.750907288090559	1.17008162748297	0.9835515443218	NA	NA	1.13338136761158	0.96042666285024	0.703266873983452	0.608224809106114	0.619682607657112	0.768627192050245	0.718888441398149	NA	NA	0.718874017369386	0.687659730597517	NA	NA	p.Thr55Val	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.32	-2.761	0.441	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55W	55	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr55Trp	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.32	-4.607	2.287	0.008346654	NA	NA	NA	NA	NA	NA	NA
T55X	55	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr55Ter	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T55Y	55	T	Y	missense	low	0.556305808249801	0.199385869965863	6	0.0813989405562135	0.396766816379906	0.715844800119696	0.483851313176572	0.890839033263205	0.64178057990389	0.568069152806453	NA	NA	0.445975887205022	0.307318883143663	0.579375143115189	0.576340148384568	0.649937497898049	0.610551592540811	0.581279064363238	NA	NA	0.57747122186714	0.54077482610388	NA	NA	p.Thr55Tyr	0	33.6	26.9	29.5	0.96	111.4	48.4	-62.3	-49.4	63.8036809815951	-1.7	1	0	21.49	0	0	0	0	7	26.2668553540404	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.32	-4.149	1.829	0.008346654	NA	NA	NA	NA	NA	NA	NA
F56A	56	F	A	missense	low	0.173629287702708	0.649252561662406	6	0.265056248377961	-0.345871412995399	0.693129988400815	1.11526111652155	0.892837213166319	-0.272305513962294	-0.306913152780188	NA	NA	-0.239870803497032	-0.147233133232102	0.437467241713645	0.710829659771368	0.650369527910793	0.337043319268829	0.291481536364027	NA	NA	0.436389077317061	0.438545406110229	NA	NA	p.Phe56Ala	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.154	-2.699	0.545	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56C	56	F	C	missense	wt-like	0.910344507303391	0.0667502867369497	6	0.0272506904483324	0.85693413547081	0.963754879135972	0.808860337217021	0.895937037315514	0.90042370746756	1.01619554188158	NA	NA	0.908721346696976	0.931929073241694	0.676955445821719	0.645566670696923	0.651039746375406	0.687941496717562	0.729700259804572	NA	NA	0.672660311048438	0.681250580595	NA	NA	p.Phe56Cys	1	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.154	-3.633	1.479	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56D	56	F	D	missense	wt-like	0.84685357447294	0.0962043387650275	4	0.0481021693825138	0.752575054904967	0.941132094040912	0.781657049601246	0.798729684471216	0.989474733899093	0.817552829920203	NA	NA	NA	NA	0.651840714126645	0.639772403898754	0.630022372603016	0.714586899853901	0.663909024354536	NA	NA	NA	NA	NA	NA	p.Phe56Asp	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.154	-3.712	1.558	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56E	56	F	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Glu	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.154	-3.289	1.135	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56F	56	F	F	synonymous	wt-like	1.04248557069412	0.26696328060999	6	0.108987302925653	0.828874382187679	1.25609675920055	0.759684405471199	0.645528465241297	1.18827860638058	1.1838705909847	NA	NA	1.22311397881179	1.25443737727512	0.745557822724204	0.635092257728595	0.59689846589507	0.77407200114476	0.785234885392975	NA	NA	0.73733247083403	0.753783174614378	NA	NA	p.Phe56=	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	0	2.8	2.8	0	228	228	0	5.2	5.2	0	165	165	0	3.32	3.32	0	NA	NA	NA	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56G	56	F	G	missense	possibly_wt-like	0.780694284638931	0.238685589950063	4	0.119342794975031	0.546786704673522	1.01460186460434	0.970289071930588	0.958844416484295	NA	NA	NA	NA	0.463385291600026	0.730258358540813	0.650267800536912	0.679950792610145	0.664641062143663	NA	NA	NA	NA	0.581052424693784	0.63589453893016	NA	NA	p.Phe56Gly	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.154	-3.193	1.039	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56H	56	F	H	missense	possibly_wt-like	0.815105190979894	0.356190061770766	6	0.145413983798133	0.530099019887062	1.10011136207273	0.801974583375718	0.705735449177137	1.28126524319784	1.15819343343591	NA	NA	0.311424417674022	0.632038019018735	0.628952326534856	0.644100013599202	0.60991592443151	0.801894997954272	0.776730511377437	NA	NA	0.549793301814239	0.613804639470511	NA	NA	p.Phe56His	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.154	-3.062	0.908	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56I	56	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Ile	1	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.154	-3.145	0.991	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56K	56	F	K	missense	wt-like	1.30148243254422	0.202481773064235	4	0.101240886532118	1.10305394117836	1.49991092391008	1.22356573106952	1.15771422887878	NA	1.22300478854194	NA	NA	NA	1.60164498168664	0.76604734630585	0.733898409439695	0.707639056192885	NA	0.798196283172005	NA	NA	NA	0.831870677777123	NA	NA	p.Phe56Lys	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.154	-3.417	1.263	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56L	56	F	L	missense	wt-like	0.975234596375865	0.178139015772185	6	0.0727249486539096	0.832696316236678	1.11777287651505	0.725935537023805	0.777844199675468	1.07068075003526	1.11228953560868	NA	NA	1.02435377073333	1.14030378517865	0.712280424291006	0.627903790265305	0.625506684977278	0.738884958211576	0.761526962653168	NA	NA	0.69644648743995	0.728114361142063	NA	NA	p.Phe56Leu	1	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.154	-1.706	-0.448	0.007192302	NA	NA	NA	NA	4.06e-06	NA	NA
F56M	56	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Met	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.154	-2.963	0.809	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56N	56	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Asn	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.154	-3.761	1.607	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56P	56	F	P	missense	low	0.597561497002076	0.074594402410965	6	0.0304530372624499	0.537874640747818	0.657248353256334	0.629217230710366	0.560087273465869	0.499585547054686	0.543241645775576	NA	NA	0.690132042040629	0.663105242965331	0.592863992313182	0.607302909998094	0.57842507462827	0.568004705367476	0.573056097889525	NA	NA	0.627695381867166	0.620791704031782	NA	NA	p.Phe56Pro	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.154	-4.526	2.372	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56Q	56	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Gln	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.154	-4.475	2.321	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56R	56	F	R	missense	wt-like	0.916683181752423	0.110696204206533	6	0.0451915361281558	0.828109398535197	1.00525696496965	1.06798546010044	0.877294048225172	0.979998536945332	0.980705660443428	NA	NA	0.790124530465304	0.803990854334866	0.676618544634509	0.700760003109589	0.647008912714356	0.711751479554434	0.717945873636882	NA	NA	0.648264344139786	0.652477086159429	NA	NA	p.Phe56Arg	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.154	-3.095	0.941	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56S	56	F	S	missense	possibly_wt-like	0.844051676922961	0.232196752118456	6	0.094793927103621	0.658258993846749	1.02984435999917	1.21611634614829	0.831274933307798	0.814608539148974	0.592737383692853	NA	NA	0.626079961391474	0.98349289784838	0.649661674660334	0.732311699615297	0.637059038444637	0.662264310876031	0.5894492779611	NA	NA	0.614519543850616	0.6928473609244	NA	NA	p.Phe56Ser	1	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.154	-3.975	1.821	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56T	56	F	T	missense	possibly_wt-like	0.824563629217571	0.192841592716839	6	0.0787272505569781	0.670261053524033	0.978866204911109	1.08403703808521	0.893014718326331	0.718228557193696	0.511358484990095	NA	NA	0.88313996649208	0.857603010218009	0.657471222917227	0.704178969474576	0.650407906615545	0.63342597429104	0.562496271569107	NA	NA	0.66739809132968	0.664534539218909	NA	NA	p.Phe56Thr	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.154	-3.984	1.83	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56V	56	F	V	missense	wt-like	0.990732270422605	0.0932557059694538	6	0.0380714825380302	0.91611353581002	1.06535100503519	1.13760605483088	0.887788350869335	0.980081264378568	0.922130378829787	NA	NA	1.06257059263296	0.954216980994104	0.701426697582578	0.715589104143738	0.649277904459315	0.711776232843614	0.698545513532332	NA	NA	0.704307881632825	0.686263163974494	NA	NA	p.Phe56Val	1	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.154	-2.549	0.395	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56W	56	F	W	missense	possibly_wt-like	0.913291353566435	0.39079125053569	6	0.159539859959431	0.600598973947387	1.22598373318548	1.21611588907029	1.42424617479166	0.673906357582621	0.624031472628963	NA	NA	1.10923865399283	0.432209573332248	0.667035922935745	0.732311602258245	0.765266399862102	0.620164107203697	0.599814001403812	NA	NA	0.713907738667793	0.568862926828597	NA	NA	p.Phe56Trp	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.154	-3.641	1.487	0.007192302	NA	NA	NA	NA	NA	NA	NA
F56X	56	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Ter	0	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F56Y	56	F	Y	missense	wt-like	1.07978360888641	0.103604869443509	6	0.0422965108340441	0.996883970979973	1.16268324679284	1.12762022763081	0.90939786533933	1.08941750188306	1.03258482351075	NA	NA	1.21988815981167	1.09979307514283	0.727065947978231	0.713462135234141	0.653950135822134	0.744491275470973	0.73512845334802	NA	NA	0.736668903496551	0.719003442608442	NA	NA	p.Phe56Tyr	1	31.6	26.7	26.3	0.839	118.2	40.3	-58.8	-35.8	1.75438596491228	-3.3	1	0	19.46	0	0	0	0	6	23.3237416928271	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.154	-2.887	0.733	0.007192302	NA	NA	NA	NA	NA	NA	NA
L57A	57	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Ala	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.596	-2.609	1.013	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57C	57	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Cys	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.596	-3.754	2.158	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57D	57	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Asp	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.596	-3.554	1.958	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57E	57	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Glu	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.596	-3.358	1.762	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57F	57	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Phe	1	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.596	-3.663	2.067	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57G	57	L	G	missense	wt-like	0.934116899430235	0.145107194226642	6	0.0592397639770342	0.818009095582595	1.05022470327788	1.19373467910827	0.999212933042623	0.89138671512187	0.815993047891767	NA	NA	0.899290501446317	0.805083519970568	0.672044774433724	0.72754443206847	0.673369210543118	0.685237493026194	0.663392418506427	NA	NA	0.670720338324329	0.652722828275096	NA	NA	p.Leu57Gly	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.596	-2.878	1.282	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57H	57	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57His	1	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.596	-3.952	2.356	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57I	57	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Ile	1	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.596	-2.623	1.027	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57K	57	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Lys	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.596	-4.1	2.504	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57M	57	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Met	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.596	-3.331	1.735	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57N	57	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Asn	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.596	-3.031	1.435	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57P	57	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Pro	1	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.596	-3.489	1.893	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57Q	57	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Gln	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.596	-3.247	1.651	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57R	57	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Arg	1	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.596	-3.654	2.058	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57S	57	L	S	missense	possibly_wt-like	1.07246006289334	0.370913571450068	2	0.262275501606464	0.558409525717489	1.58651060006918	0.810184561286871	1.3347355644998	NA	NA	NA	NA	NA	NA	0.695880940605806	0.645848728794813	0.745913152416799	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Ser	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.596	-2.91	1.314	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57T	57	L	T	missense	possibly_low	0.679067603165264	0.436657807522973	6	0.178264803438952	0.329675008713805	1.02846019761672	1.1973223570597	1.06536897127473	0.343606196474262	0.922413032030017	NA	NA	0.142938677736395	0.402756384416483	0.62495589288316	0.72830860305876	0.687672924636143	0.521333343523542	0.698639129366829	NA	NA	0.515134930142028	0.562238861130177	NA	NA	p.Leu57Thr	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.596	-2.721	1.125	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57V	57	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Val	1	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.596	-2.645	1.049	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57W	57	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Trp	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.596	-3.426	1.83	0.006216396	NA	NA	NA	NA	NA	NA	NA
L57X	57	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Ter	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L57Y	57	L	Y	missense	possibly_wt-like	0.79096065932092	0.400802318189732	6	0.163626861214911	0.470257904436359	1.11166341420548	1.23435669052873	0.988748430774376	1.07729108310776	0.499914748603027	NA	NA	0.78757063440747	0.157882368504152	0.659422828375662	0.73619687053006	0.67110666199017	0.740862869041359	0.55870606176158	NA	NA	0.647738994761154	0.507166333198546	NA	NA	p.Leu57Tyr	0	28.8	28.8	27.9	0.451	81.7	136	-96.3	-0.6	8.90052356020942	-5	1	0	20.17	0	0	0	0	6	24.5110093855633	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.596	-4.536	2.94	0.006216396	NA	NA	NA	NA	NA	NA	NA
K58A	58	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Ala	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.504	-2.469	-0.035	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58C	58	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Cys	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.504	-4.058	1.554	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58D	58	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Asp	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.504	-2.876	0.372	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58E	58	K	E	missense	wt-like	1.19892068586669	0.257707353535152	6	0.105208586520692	0.992715645421764	1.40512572631161	0.709949330880875	1.14713818088156	1.24877811694168	1.42587084926026	NA	NA	1.30382879619804	1.35795884103771	0.765500611549085	0.624498748022214	0.705352390140491	0.792174362375723	0.865386308085353	NA	NA	0.753935918351088	0.777065304747082	NA	NA	p.Lys58Glu	1	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.504	-2.851	0.347	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58F	58	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Phe	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.504	-4.21	1.706	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58G	58	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Gly	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.504	-2.305	-0.199	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58H	58	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58His	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.504	-3.382	0.878	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58I	58	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Ile	1	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.504	-3.283	0.779	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58L	58	K	L	missense	possibly_wt-like	0.753802766712796	0.209499587340109	6	0.0855278483844844	0.586171264204005	0.921434269221588	0.980791025736528	0.950433136423435	0.880211743966384	0.523582293514602	NA	NA	0.526281833651836	0.661516566983993	0.641628426427046	0.682187695851883	0.662822444397467	0.681893773998949	0.566544844289401	NA	NA	0.593990562557175	0.620434408456624	NA	NA	p.Lys58Leu	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.504	-2.646	0.142	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58M	58	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Met	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.504	-5.168	2.664	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58N	58	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Asn	1	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.504	-2.402	-0.102	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58P	58	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Pro	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.504	-3.075	0.571	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58Q	58	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Gln	1	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.504	-2.848	0.344	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58R	58	K	R	missense	wt-like	1.16195288163078	0.195990184314365	6	0.0800126576940368	1.00513095424314	1.31877480901843	0.843244971676621	1.14961605837397	1.26800256164991	1.372159502857	NA	NA	1.03745485833666	1.30123933689054	0.735098570445198	0.652890555538728	0.705888136417868	0.797926604655793	0.84759690215818	NA	NA	0.699141447640346	0.764309004472528	NA	NA	p.Lys58Arg	1	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.504	-2.956	0.452	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58S	58	K	S	missense	wt-like	1.19245403465652	0.231099487216583	4	0.115549743608291	0.965980698761435	1.41892737055161	1.06319818361732	0.936447442265058	1.34172113848358	NA	NA	NA	1.42844937426014	NA	0.739655661371536	0.699740319107729	0.659798572715005	0.81998430884049	NA	NA	NA	0.779571003635343	NA	NA	NA	p.Lys58Ser	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.504	-2.627	0.123	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58T	58	K	T	missense	wt-like	1.13244385958917	0.302221959832989	6	0.123381598442456	0.890620370286972	1.37426734889137	0.586958128947526	1.07479134751758	1.18982058616489	1.32779467788278	NA	NA	1.14491597434798	1.47038244267427	0.747890064568472	0.598301773307436	0.689710153277038	0.774533384630468	0.832903100322925	NA	NA	0.721246744506476	0.802349538838789	NA	NA	p.Lys58Thr	1	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.504	-3.083	0.579	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58V	58	K	V	missense	wt-like	1.27738685001073	0.259578887996326	6	0.105972637265011	1.06968429762458	1.48508940239688	1.0607938821694	0.966796288523415	1.40119254591972	1.38404232586727	NA	NA	1.17795611482502	1.67353994275956	0.782911157626983	0.699228205856963	0.666360350468529	0.837779046191886	0.851532539155686	NA	NA	0.728043269062081	0.848039960733014	NA	NA	p.Lys58Val	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.504	-3.161	0.657	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58W	58	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys58Trp	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.504	-5.976	3.472	0.008286273	NA	NA	NA	NA	NA	NA	NA
K58X	58	K	X	nonsense	low	-0.424739035615843	0.366583215194864	6	0.14965697091605	-0.718061308646659	-0.131416762585028	-0.0728055329000509	0.0531503117089566	-0.535047405928979	-0.398074245095284	NA	NA	-0.91701371679034	-0.678643624689362	0.308063872737056	0.457772924938943	0.468819337073106	0.258427003289142	0.26128862956586	NA	NA	0.297097343946564	0.319030401527548	NA	NA	p.Lys58Ter	1	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K58Y	58	K	Y	missense	possibly_wt-like	0.946081053445578	0.428821837286374	6	0.175065781985735	0.602958425828197	1.28920368106296	1.47536296023238	1.30370605067771	0.985144835237218	1.01784272858119	NA	NA	0.388074294410017	0.506355451534963	0.721768571815635	0.787530909504254	0.739204206324839	0.713291329213018	0.730245814418252	NA	NA	0.565560570412333	0.585538444372264	NA	NA	p.Lys58Tyr	0	31	31.3	29.7	0.253	83.2	-0.9	-54.9	122.3	74.3478260869565	-2.1	0	0	23.13	0	0	0	0	7	28.1903984171447	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.504	-4.787	2.283	0.008286273	NA	NA	NA	NA	NA	NA	NA
G59A	59	G	A	missense	wt-like	0.965669821995852	0.186418184931308	6	0.0761049053095827	0.816506948542239	1.11483269544947	1.06964388667133	1.20137971440578	0.754148519516534	0.750488207303498	NA	NA	1.08842070677468	0.929937897303292	0.690958004056984	0.701113245929084	0.717080048087232	0.644173765923402	0.641696961634604	NA	NA	0.709625381286056	0.680802762184884	NA	NA	p.Gly59Ala	1	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.92	-2.378	0.458	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59C	59	G	C	missense	possibly_wt-like	0.815231224167688	0.160720293051602	6	0.0656137848811678	0.686630568911241	0.943831879424136	0.623496607496802	0.812943131213349	0.670505476553953	0.792744730476667	NA	NA	0.942504838289027	1.04919256097633	0.64439398641177	0.606084424290802	0.633095487074633	0.619146512576675	0.655692485748907	NA	NA	0.679609746700475	0.70762331222014	NA	NA	p.Gly59Cys	1	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.92	-5.437	3.517	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59D	59	G	D	missense	possibly_wt-like	1.03579954377909	0.340245556301569	2	0.240589940129428	0.564251926082761	1.50734716147542	NA	NA	NA	NA	0.79520960364966	1.27638948390852	NA	NA	0.673752557551545	NA	NA	NA	NA	0.622257706318812	0.725247408784277	NA	NA	NA	NA	p.Gly59Asp	1	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.92	-3.035	1.115	0.007091588	NA	NA	NA	NA	1.22e-05	NA	NA
G59E	59	G	E	missense	wt-like	1.17427231282336	0.422973544667619	5	0.189159519712168	0.803526466854622	1.54501815879211	NA	0.447852374533777	1.38926138315605	1.20895634367502	NA	NA	1.52856271785026	1.29672874490172	0.793543383829158	NA	0.554158568524144	0.834209063290367	0.793543383829158	NA	NA	0.800164826428766	0.763294565670735	NA	NA	p.Gly59Glu	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.92	-3.021	1.101	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59F	59	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly59Phe	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.92	-4.639	2.719	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59G	59	G	G	synonymous	wt-like	1.05698552459155	0.0767129744571352	6	0.0313179406785234	0.995603488791682	1.11836756039142	1.03636239814326	1.10065252677763	1.13183789230503	1.13336217766984	NA	NA	0.954511369429579	0.985186783223964	0.694662987210671	0.694024329813666	0.695301644607677	0.757184092716188	0.768506303308113	NA	NA	0.682079551082242	0.69322831824775	NA	NA	p.Gly59=	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59H	59	G	H	missense	possibly_low	0.630583459794285	0.480868363504326	6	0.196313687338797	0.245815702937987	1.01535121665058	1.33143196642221	1.14567157286476	0.410488676592246	0.253316851324632	NA	NA	0.227546024969251	0.415045666592604	0.553174161927933	0.756873784878697	0.705035292225932	0.541345585009294	0.477031883227	NA	NA	0.532539090800857	0.565002738846572	NA	NA	p.Gly59His	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.92	-3.82	1.9	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59I	59	G	I	missense	possibly_wt-like	0.744433147767077	0.129330296751383	6	0.0527988725539362	0.640949259137042	0.847917036397113	0.800750874242376	0.725932088925192	0.624656879914726	0.678647173341367	NA	NA	0.659357631213472	0.97725423896533	0.619633931189054	0.64383936505914	0.614282675650537	0.605427924598052	0.617902932980306	NA	NA	0.621364929397801	0.691444277325217	NA	NA	p.Gly59Ile	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.92	-2.968	1.048	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59K	59	G	K	missense	possibly_low	0.572220001386666	0.610929591155894	6	0.249410961183181	0.0833835001181145	1.06105650265522	1.27791497086664	1.2820776723228	0.313144220372205	-0.295262506116115	NA	NA	0.389864570280496	0.465581080593961	0.571148533677529	0.74547473065903	0.734527896368084	0.512218663254327	0.295340275656563	NA	NA	0.565928839243498	0.576368228111561	NA	NA	p.Gly59Lys	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.92	-3.289	1.369	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59L	59	G	L	missense	wt-like	0.948635965825141	0.0862286583840502	6	0.0352027023742809	0.879639937013067	1.01763199463721	0.893234760315365	0.922813315361594	1.01336087859425	1.05583348029999	NA	NA	0.820681995314067	0.985891365065582	0.678462549384448	0.663538319024087	0.656850714010847	0.721733992709306	0.74282849850757	NA	NA	0.654550169720521	0.69338677974481	NA	NA	p.Gly59Leu	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.92	-1.958	0.038	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59M	59	G	M	missense	wt-like	1.13241586274052	0.189366299582861	6	0.0773084680761705	0.980894049611266	1.28393767586978	0.840478548911283	0.956379928948482	1.22708457453822	1.28439442959239	NA	NA	1.18594002570266	1.30021766875012	0.746882414920873	0.652301310892813	0.664108210932494	0.785683329021494	0.818528770020696	NA	NA	0.729685600043311	0.764079229798435	NA	NA	p.Gly59Met	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.92	-4.204	2.284	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59N	59	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly59Asn	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.92	-3.225	1.305	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59P	59	G	P	missense	wt-like	0.971736376225286	0.237724103821299	6	0.0970504589870991	0.781520971927491	1.16195178052308	0.564869001810607	1.01174539516379	1.01740613136962	0.891229165124944	NA	NA	1.28698503738797	1.05818352649479	0.698978152767624	0.593596816400104	0.676078876355238	0.72294439303042	0.688310911887633	NA	NA	0.750471071691588	0.709645393647615	NA	NA	p.Gly59Pro	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.92	-2.53	0.61	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59Q	59	G	Q	missense	possibly_wt-like	1.01187301658889	0.393470589724519	5	0.175965397154191	0.666987175641391	1.35675885753639	1.41272906354256	1.22631420531243	1.15304644468061	0.402821787568327	NA	NA	NA	0.864453581840529	0.722471178489154	0.774189966558104	0.722471178489154	0.763530009777798	0.526548497072184	NA	NA	NA	0.666075242897179	NA	NA	p.Gly59Gln	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.92	-3.763	1.843	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59R	59	G	R	missense	wt-like	0.845253891820015	0.125609852922839	6	0.0512800077211661	0.744746923559593	0.945760860080436	0.657262532804315	0.776036987885632	0.780927753131778	0.942677363567186	NA	NA	0.954533975034459	0.960084738496717	0.667135357779221	0.613276524844314	0.625115944518234	0.652186514388565	0.705350754446025	NA	NA	0.682084201169876	0.687582831305284	NA	NA	p.Gly59Arg	1	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.92	-3.897	1.977	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59S	59	G	S	missense	possibly_low	0.521596355181381	0.41879968806086	3	0.241794112638469	0.0476886027361615	0.995504107626601	0.0946536216248185	0.931747933006202	NA	0.538387510913124	NA	NA	NA	NA	0.571448389625333	0.49344151885368	0.6587824835021	NA	0.571448389625333	NA	NA	NA	NA	NA	NA	p.Gly59Ser	1	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.92	-2.962	1.042	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59T	59	G	T	missense	possibly_wt-like	0.883043711762144	0.24595965072675	6	0.100412606932285	0.686238618581089	1.0798488049432	0.584902303025512	0.981527534123916	0.700619910057615	1.17607484078594	NA	NA	1.12854486689181	0.72659281568807	0.652307786037526	0.597863884915012	0.669545419147588	0.628157202886286	0.782652902737926	NA	NA	0.717879124628902	0.635070152927463	NA	NA	p.Gly59Thr	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.92	-3.113	1.193	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59V	59	G	V	missense	possibly_wt-like	0.855999530592663	0.386152818354829	6	0.157646227951162	0.547018601509795	1.16498045967553	0.521413530713507	0.868877681151968	1.30969156515337	1.18715392926907	NA	NA	0.949013036697115	0.299847440570952	0.663068855617278	0.584340854512957	0.64518919509622	0.810400579962029	0.786322339747559	NA	NA	0.680948516138337	0.539094487631698	NA	NA	p.Gly59Val	1	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.92	-2.454	0.534	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59W	59	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly59Trp	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.92	-5.874	3.954	0.007091588	NA	NA	NA	NA	NA	NA	NA
G59X	59	G	X	nonsense	low	-0.0729495096696549	0.354618403686037	6	0.144772357071849	-0.356698115487451	0.210799096148141	0.459802437158256	0.113623579295901	-0.135068161440524	-0.0471314463742026	NA	NA	-0.604659537840016	-0.224263928817344	0.399663930246853	0.571217767376274	0.481894369268955	0.378106794108369	0.377522243536267	NA	NA	0.361350183572256	0.421221066385336	NA	NA	p.Gly59Ter	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G59Y	59	G	Y	missense	possibly_wt-like	1.10515411252731	0.732763108281301	4	0.366381554140651	0.387059461811821	1.82324876324279	0.064152791439101	NA	1.44220693151658	NA	NA	NA	1.1692349644908	1.74502176266275	0.788150224941391	0.48694487954457	NA	0.850051165699211	NA	NA	NA	0.726249284183572	0.864116327629498	NA	NA	p.Gly59Tyr	0	29.6	34.8	29.3	0.459	106	127.9	78.6	4	87.6288659793814	-0.8	0	0	25.01	0	0	0	0	3	30.1711809997115	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.92	-4.731	2.811	0.007091588	NA	NA	NA	NA	NA	NA	NA
K60A	60	K	A	missense	possibly_wt-like	0.82186052819942	0.208083138093622	6	0.0849495854010773	0.655362400311699	0.988358656087141	1.10885280341482	0.938130571758645	0.702701415716475	0.816177399204761	NA	NA	0.4987760609754	0.866524918126423	0.661807980748201	0.709464696962789	0.660162485121207	0.62878002060814	0.663453476375195	NA	NA	0.588332485541849	0.666541089487866	NA	NA	p.Lys60Ala	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.202	-2.29	0.088	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60C	60	K	C	missense	wt-like	1.09781879626448	0.235607857934056	6	0.096186505221431	0.909296710231703	1.28634088229726	0.830535813981086	0.810548832039606	1.1783592945069	1.10725200847542	NA	NA	1.39755616444294	1.26266066414095	0.757745559068738	0.650183520583687	0.63257781141343	0.771103994213221	0.759858514158693	NA	NA	0.773216113610892	0.755632603978783	NA	NA	p.Lys60Cys	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.202	-5.573	3.371	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60D	60	K	D	missense	wt-like	0.797374968530701	0.0858594887819594	6	0.0350519895153361	0.728674331494166	0.866075605567235	0.818853971401809	0.937525756892975	0.803056211442526	0.792958221792828	NA	NA	0.757380263952201	0.674475385701865	0.651729248692116	0.647695302484663	0.660031717028846	0.658807681107276	0.655763194899569	NA	NA	0.641528682359952	0.623348865930366	NA	NA	p.Lys60Asp	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.202	-2.792	0.59	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60E	60	K	E	missense	possibly_low	0.508000411922344	0.385846679329393	6	0.157521247217383	0.199264440576443	0.816736383268245	0.677612986428931	1.10376560568392	0.508027421481442	0.582259646960199	NA	NA	0.124578886472453	0.0517579245071179	0.578254825914473	0.617611146432346	0.695974728906776	0.570530640848975	0.585979010979971	NA	NA	0.511358227913784	0.483298788965728	NA	NA	p.Lys60Glu	1	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.202	-2.444	0.242	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60F	60	K	F	missense	wt-like	1.28765311170678	0.143397186033608	6	0.0585416560555491	1.17291357424258	1.40239264917099	1.24627689275388	1.07457322178189	1.22190295965595	1.30121798268884	NA	NA	1.48667487118022	1.39527274217992	0.784795084173545	0.738735858940438	0.68966299192574	0.784132912109214	0.824100795955833	NA	NA	0.791548283812303	0.785457256237875	NA	NA	p.Lys60Phe	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.202	-4.844	2.642	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60G	60	K	G	missense	possibly_wt-like	0.78702955006478	0.12528442492062	6	0.0511471522955912	0.686782973653636	0.887276126475924	0.888463335253053	0.776660833079679	0.846933930172159	0.92001985090752	NA	NA	0.702028128104111	0.588071222872157	0.646332239245747	0.662522011355359	0.625250827191568	0.671936552846367	0.697846498511409	NA	NA	0.630142467136135	0.603916442064896	NA	NA	p.Lys60Gly	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.202	-2.997	0.795	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60H	60	K	H	missense	wt-like	1.05748796029822	0.122843056685471	6	0.0501504678871988	0.959194849431479	1.15578107116496	0.91698419128395	1.10055872286939	1.19016632524856	1.01560252298161	NA	NA	0.929515007743941	1.19210099166187	0.712392606373555	0.668596918605149	0.695281363098686	0.77463683495141	0.729503849648424	NA	NA	0.676937672641523	0.739763629400273	NA	NA	p.Lys60His	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.202	-3.712	1.51	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60I	60	K	I	missense	possibly_wt-like	0.734612539048223	0.253896261051768	6	0.103652714529551	0.531456951670492	0.937768126425954	0.779968417551441	0.946206367645689	0.57932523292161	1.02695824771238	NA	NA	0.327506013020119	0.747710955438093	0.639616190552264	0.639412727349408	0.661908567240524	0.591864015709315	0.733264909654558	NA	NA	0.553101367581665	0.63981965375512	NA	NA	p.Lys60Ile	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.202	-3.941	1.739	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60L	60	K	L	missense	wt-like	0.893096248876913	0.116653261083604	6	0.047623494414416	0.799755915006714	0.986436582747113	0.912166951831826	0.819154269503956	1.0127804919147	1.04731039940212	NA	NA	0.791200016156123	0.77596536445276	0.658028214765801	0.66757085252775	0.634438408275407	0.721560332307273	0.74000562110837	NA	NA	0.648485577003852	0.646174112082822	NA	NA	p.Lys60Leu	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.202	-3.181	0.979	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60M	60	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Met	1	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.202	-4.106	1.904	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60N	60	K	N	missense	wt-like	1.08487408340897	0.133117859807769	6	0.0543451386967297	0.978359568828541	1.19138859798939	0.927089415898104	1.19037499218276	1.12551533221959	0.962055502696096	NA	NA	1.26786164282329	1.03634761463395	0.713234783394859	0.670749319017071	0.714700697621912	0.755292287881579	0.711768869167805	NA	NA	0.746537292389538	0.70473446481187	NA	NA	p.Lys60Asn	1	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.202	-3.14	0.938	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60P	60	K	P	missense	possibly_low	0.662536691114567	0.29476719577313	6	0.120338203759207	0.426678145782279	0.898395236446855	1.02373485590438	1.03364961413869	0.474690933901013	0.575660579859418	NA	NA	0.336989436526425	0.53049472635748	0.587380388671004	0.691334678850493	0.680814826300558	0.560555863619281	0.583793374401154	NA	NA	0.555052155919765	0.590967402940855	NA	NA	p.Lys60Pro	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.202	-2.398	0.196	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60Q	60	K	Q	missense	wt-like	1.10013851187212	0.146312690892996	6	0.0597319059302334	0.98306612752093	1.21721089622331	1.06867615695522	1.08373187585809	1.06686418390455	1.32087478733474	NA	NA	1.18233410432334	0.878349962856792	0.714925482203817	0.70090712069	0.691643200730314	0.73774298436552	0.830611205775979	NA	NA	0.728943843717634	0.669200559516892	NA	NA	p.Lys60Gln	1	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.202	-2.747	0.545	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60R	60	K	R	missense	wt-like	1.08176600861477	0.120639872366266	6	0.0492510216553066	0.985235779968571	1.17829623726098	0.940574595552305	1.07622022738456	1.1924618354654	1.24085771024662	NA	NA	1.08216698797009	0.958314695069673	0.699179026757766	0.673621645694688	0.690019093921563	0.77532368604771	0.804109239976441	NA	NA	0.708338959593969	0.687184745923652	NA	NA	p.Lys60Arg	1	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.202	-2.473	0.271	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60S	60	K	S	missense	wt-like	0.980532152213675	0.0767146754415673	6	0.03131863510251	0.919148755367804	1.04191554905955	0.874245166415476	0.970561043369099	0.957781964088023	0.954931652451855	NA	NA	1.10350826884185	1.02216481811574	0.703324340282031	0.659493558883366	0.667174334775662	0.705103947641414	0.70940942237964	NA	NA	0.712728969363868	0.701544732922647	NA	NA	p.Lys60Ser	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.202	-2.69	0.488	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60T	60	K	T	missense	wt-like	1.09796172829347	0.228445691635943	6	0.0932625630742085	0.915170463562126	1.28075299302481	0.766476928949254	1.05409560820291	1.0194487095614	1.1593317205203	NA	NA	1.47052438773369	1.11789301479327	0.723314854422502	0.636539056873631	0.685235490857531	0.723555563070096	0.777107516467831	NA	NA	0.78822604741305	0.723074145774908	NA	NA	p.Lys60Thr	1	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.202	-3.008	0.806	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60V	60	K	V	missense	wt-like	1.02910159952337	0.171954653545113	6	0.0702001933470983	0.891511748855311	1.16669145019143	0.919624863514581	0.823641689248484	0.955477060942515	1.20965663512837	NA	NA	1.26346784244338	1.0027415058629	0.700795343671406	0.669159378541863	0.635408641239115	0.704414286039933	0.793775323070402	NA	NA	0.745633465355412	0.697176401302878	NA	NA	p.Lys60Val	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.202	-3.105	0.903	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60W	60	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Trp	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.202	-5.975	3.773	0.008209326	NA	NA	NA	NA	NA	NA	NA
K60X	60	K	X	nonsense	low	0.134875741430064	0.39022270305934	5	0.17451289808088	-0.20716325364617	0.476914736506298	-0.280333846812734	0.39917542040394	NA	0.630307917524029	NA	NA	0.138740801667111	-0.213511585632025	0.5142714057328	0.413569649365481	0.543634038135101	NA	0.601892784258734	NA	NA	0.5142714057328	0.423639284252176	NA	NA	p.Lys60Ter	1	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K60Y	60	K	Y	missense	wt-like	0.973296504474507	0.0832201677312157	6	0.0339744912083848	0.906707725313	1.03988528363601	0.854240893116478	0.975789279114703	1.02438899442379	1.09943975631922	NA	NA	0.949454890058019	0.936465213814834	0.681655086463987	0.655232673278839	0.668304740877879	0.725033770419768	0.757271065991435	NA	NA	0.681039407616823	0.68227076531115	NA	NA	p.Lys60Tyr	0	26.8	33.5	27	0.744	34	-179.2	-101.7	139.4	42.1739130434783	-3.2	0	0	24.46	0	0	0	0	5	27.1683324882129	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.202	-4.797	2.595	0.008209326	NA	NA	NA	NA	NA	NA	NA
S61A	61	S	A	missense	wt-like	1.20610617664936	0.345117020757011	2	0.244034585680181	0.727807177734053	1.68440517556467	1.45014076232954	0.96207159096918	NA	NA	NA	NA	NA	NA	0.723748713813811	0.782158612377913	0.665338815249708	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Ala	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.244	-2.257	0.013	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61C	61	S	C	missense	wt-like	1.17015078525631	0.186773877002186	4	0.0933869385010929	0.987115749167715	1.35318582134491	1.34920873911415	1.26294884230943	1.150471151455	NA	NA	NA	NA	0.917974408146679	0.745526116887706	0.760660215594068	0.730392018181344	0.7627594434077	NA	NA	NA	NA	0.678112155799872	NA	NA	p.Ser61Cys	1	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.244	-5.565	3.321	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61D	61	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Asp	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.244	-2.824	0.58	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61E	61	S	E	missense	wt-like	1.42273516379639	0.440490856957602	6	0.179829639317903	1.07027554738047	1.77519478021231	0.725356773841697	1.09769832136567	1.54335376714171	1.49154019513746	NA	NA	1.91654501982076	1.76191690547105	0.873945412467361	0.627780514419479	0.694662910627925	0.880315816419084	0.887136249745922	NA	NA	0.879974754728404	0.867916070206318	NA	NA	p.Ser61Glu	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.244	-2.442	0.198	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61F	61	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Phe	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.244	-4.851	2.607	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61G	61	S	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Gly	1	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.244	-2.958	0.714	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61H	61	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61His	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.244	-3.424	1.18	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61I	61	S	I	missense	possibly_wt-like	0.956032321711252	0.256617689380618	4	0.128308844690309	0.704551607220302	1.2075130362022	1.24690809098406	1.08489258057897	NA	NA	NA	NA	0.681918415227372	0.810410200054601	0.67290748262353	0.738870303387002	0.691894158751948	NA	NA	NA	NA	0.626005797152305	0.653920806495111	NA	NA	p.Ser61Ile	1	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.244	-3.663	1.419	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61K	61	S	K	missense	possibly_low	0.700272308004495	0.191551659915847	6	0.0782006376961596	0.547001874551956	0.853542741457033	0.637260663734682	0.938093166966074	0.654144518667006	0.380677368384711	NA	NA	0.780925679250364	0.810532451024131	0.63031158114017	0.609016151337684	0.660154397764815	0.61425106851428	0.519214179683802	NA	NA	0.646372093766059	0.65394830091876	NA	NA	p.Ser61Lys	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.244	-2.604	0.36	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61L	61	S	L	missense	wt-like	1.47951713022992	0.0481269421382376	2	0.0340308871437204	1.41281781706628	1.54621644339356	NA	NA	1.4454862430862	NA	NA	NA	NA	1.51354801737364	0.831544962638733	NA	NA	0.851032384920185	NA	NA	NA	NA	0.812057540357281	NA	NA	p.Ser61Leu	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.244	-3.437	1.193	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61M	61	S	M	missense	possibly_wt-like	0.899646946359564	0.284600166422635	5	0.127277063705753	0.650188485438278	1.14910540728085	NA	1.0792667958442	0.446967740476087	0.85158950725292	NA	NA	1.18854035397252	0.931870334252092	0.681237370109463	NA	0.690677797879298	0.552260668216881	0.675182103694941	NA	NA	0.730220500763574	0.681237370109463	NA	NA	p.Ser61Met	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.244	-4.396	2.152	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61N	61	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Asn	1	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.244	-2.738	0.494	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61P	61	S	P	missense	wt-like	1.02213254142466	0.296505964670447	6	0.121048053189048	0.784882716775432	1.25938236607388	1.37376850348386	1.40135437816351	0.740425600105027	0.864158594194368	NA	NA	0.763815831566335	0.989272341034831	0.686746100099521	0.765891415192743	0.760316924004799	0.640067662551217	0.679345033964024	NA	NA	0.642852511274938	0.694147166235018	NA	NA	p.Ser61Pro	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.244	-2.446	0.202	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61Q	61	S	Q	missense	possibly_low	0.706808604560594	0.267082251281927	5	0.119442813890014	0.472704991124047	0.940912217997142	1.04151838831617	0.351080688367164	0.661206168720918	0.594413717403103	NA	NA	0.885824059995613	NA	0.616364020155988	0.695122549377879	0.533235391015074	0.616364020155988	0.590004486177575	NA	NA	0.667950222983569	NA	NA	NA	p.Ser61Gln	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.244	-2.797	0.553	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61R	61	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Arg	1	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.244	-2.841	0.597	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61T	61	S	T	missense	wt-like	1.16011630695361	0.142594593801385	6	0.0582139991488044	1.04601896522591	1.27421364868131	1.17336294238309	0.96071825181505	1.04716158645087	1.35055193399233	NA	NA	1.15613391605019	1.27276921103015	0.727701001824727	0.723205277206199	0.665046207396383	0.73184767161031	0.840440391674399	NA	NA	0.723554332039144	0.757906031107545	NA	NA	p.Ser61Thr	1	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.244	-2.823	0.579	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61V	61	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Val	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.244	-3.142	0.898	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61W	61	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Trp	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.244	-6	3.756	0.008182075	NA	NA	NA	NA	NA	NA	NA
S61X	61	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Ter	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S61Y	61	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser61Tyr	0	23.1	34.2	27.4	0.998	63	-6.3	-139.9	131.8	77.6223776223776	-0.6	0	0	22.56	0	0	0	0	4	27.2881639211964	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.244	-4.803	2.559	0.008182075	NA	NA	NA	NA	NA	NA	NA
G62A	62	G	A	missense	wt-like	1.17408549299657	0.0801343161072638	6	0.0327146975582813	1.10996586401722	1.23820512197592	1.1158606240628	1.23110685567703	1.07568921799772	1.21337718841866	NA	NA	1.12543035162902	1.28304872019417	0.731945486436542	0.710957354140174	0.72350740590535	0.740383566967735	0.795007584728074	NA	NA	0.717238453034996	0.760217907904475	NA	NA	p.Gly62Ala	1	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.596	-2.47	0.874	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62C	62	G	C	missense	possibly_wt-like	0.730975286375173	0.271300823753477	6	0.110758097498795	0.51389340428136	0.948057168468987	1.03984157178588	1.08786363203314	0.604997677740265	0.407463278153047	NA	NA	0.596983972361237	0.64870158617747	0.613043325801764	0.694765389519655	0.692536535044297	0.599545596361442	0.528085776728121	NA	NA	0.608534351261891	0.617552300341637	NA	NA	p.Gly62Cys	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.596	-5.544	3.948	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62D	62	G	D	missense	possibly_low	0.614712923708284	0.145175476278478	2	0.102654563738498	0.413513675932156	0.815912171484412	NA	NA	0.717367487446782	0.512058359969785	NA	NA	NA	NA	0.59794820108842	NA	NA	0.633168329304177	0.562728072872662	NA	NA	NA	NA	NA	NA	p.Gly62Asp	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.596	-2.561	0.965	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62E	62	G	E	missense	wt-like	0.97964882436913	0.138877560445647	6	0.0566965266357273	0.868525674114589	1.09077197462367	1.04206593113134	1.11293280824131	1.0290685231953	1.08452640180575	NA	NA	0.811104372009914	0.798194909831157	0.696597980658775	0.695239175323954	0.697956785993596	0.726433955634936	0.75233170522427	NA	NA	0.652580004005994	0.651173569678182	NA	NA	p.Gly62Glu	1	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.596	-2.627	1.031	0.006919057	NA	NA	NA	NA	4.06e-06	NA	NA
G62F	62	G	F	missense	wt-like	0.920303721586657	0.198934211057283	6	0.081214551578913	0.761126125471417	1.0794813177019	0.70661136246311	0.749449858284607	0.920946703746861	1.03364535888938	NA	NA	1.24737881915173	0.863790226984255	0.680004169259913	0.623787764855416	0.619367494179763	0.694082285109799	0.735479706772371	NA	NA	0.742323871621892	0.665926053410027	NA	NA	p.Gly62Phe	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.596	-4.812	3.216	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62G	62	G	G	synonymous	wt-like	1.10132133866707	0.089519223488872	6	0.0365460699529845	1.02969235778274	1.1729503195514	1.02542819498763	0.994193396077202	1.19774966420764	1.20508474621767	NA	NA	1.12892723836309	1.05654479214917	0.71361731012662	0.691695357992173	0.672283927573469	0.776905883740416	0.792261095758434	NA	NA	0.717957780380859	0.70927683987238	NA	NA	p.Gly62=	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62H	62	G	H	missense	wt-like	1.00859637109702	0.127209620707451	6	0.0519331101843732	0.906809345530499	1.11038339666354	0.937094465253703	1.08194665940989	0.888383709070887	0.892076344446436	NA	NA	1.03999977916505	1.21207726923616	0.689924358441319	0.672880382222151	0.691257215923006	0.684338948561793	0.688591500959633	NA	NA	0.699664950768738	0.74425632373773	NA	NA	p.Gly62His	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.596	-3.734	2.138	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62I	62	G	I	missense	possibly_low	0.701241533479864	0.233971663091949	6	0.0955185314742753	0.514028651934128	0.888454415025599	1.00344442791167	0.943499995963115	0.752768450605066	0.520349128855314	NA	NA	0.460765131148349	0.52662206639567	0.616928632297171	0.687012842648215	0.661323417829956	0.643760828599988	0.565474007633741	NA	NA	0.580513444393085	0.590096435994354	NA	NA	p.Gly62Ile	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.596	-4.471	2.875	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62K	62	G	K	missense	wt-like	0.984483266120319	0.19329790109897	6	0.0789135376739075	0.829815574386816	1.13915095785382	1.06661080150097	1.18444361499089	0.8571230269618	1.08716882007792	NA	NA	0.655532330064212	1.05602100312612	0.704813120733116	0.700467202518932	0.71341826406335	0.674985283472329	0.753206884388839	NA	NA	0.620578045540222	0.7091590389473	NA	NA	p.Gly62Lys	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.596	-2.65	1.054	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62L	62	G	L	missense	possibly_wt-like	0.778583485853831	0.163257672215702	6	0.0666496655871702	0.647952541721339	0.909214429986323	0.912902973679053	1.04193276550188	0.738193360466451	0.691961940046556	NA	NA	0.650619836757892	0.635890038671157	0.630856289117989	0.667727624275796	0.6826057411143	0.639399742961177	0.622312835274802	NA	NA	0.619567520739069	0.614670964380938	NA	NA	p.Gly62Leu	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.596	-3.496	1.9	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62M	62	G	M	missense	wt-like	1.06615784891176	0.381045043500143	5	0.170408523951137	0.732163279308898	1.40015241851462	0.983586531321224	1.0425245646217	0.610522725658622	NA	NA	NA	1.02461109136263	1.66954433159461	0.682783135102546	0.682783135102546	0.682733695049219	0.601198773590628	NA	NA	NA	0.696499419599149	0.847141341879291	NA	NA	p.Gly62Met	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.596	-5.214	3.618	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62N	62	G	N	missense	wt-like	1.28951342165757	0.202658750540313	6	0.0827350884556254	1.12735562802681	1.45167121528833	1.01247408037405	1.06379510191525	1.44303536527054	1.4969802177524	NA	NA	1.33811989779934	1.38267586683383	0.7718069861605	0.68893614751492	0.687332635556879	0.850299045507345	0.888938006302602	NA	NA	0.760989771957852	0.782624200363148	NA	NA	p.Gly62Asn	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.596	-2.603	1.007	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62P	62	G	P	missense	possibly_low	0.648398696122182	0.381105737424125	6	0.155585765789369	0.343456198667935	0.953341193576429	1.07315229254057	1.17579948203632	0.266436104723087	0.416866651554866	NA	NA	0.552529656178731	0.40560798969952	0.581135032107196	0.701860532063384	0.711549300780957	0.498242894292625	0.531200210413581	NA	NA	0.599389872843375	0.562880191371016	NA	NA	p.Gly62Pro	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.596	-3.042	1.446	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62Q	62	G	Q	missense	possibly_wt-like	0.823783229794104	0.267266026982974	6	0.109110898614868	0.609929798188162	1.03763666140005	0.364363196181035	0.693601659312312	0.836001276596369	1.02987511343428	NA	NA	1.10321003133691	0.915648101903713	0.673127152481808	0.550889326452241	0.607292456253407	0.668665338874444	0.73423098687728	NA	NA	0.71266762039572	0.677588966089171	NA	NA	p.Gly62Gln	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.596	-3.012	1.416	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62R	62	G	R	missense	wt-like	1.13816889736557	0.142121398896446	6	0.0580208181378067	1.02445018346192	1.25188761126922	1.01007472803921	0.951390409928235	1.19990881140353	1.20521916615185	NA	NA	1.34093078292339	1.1214894857472	0.742725491348499	0.688425088419151	0.66302941819589	0.777551932975002	0.792305616161178	NA	NA	0.761567985291475	0.723882997405523	NA	NA	p.Gly62Arg	1	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.596	-3.047	1.451	0.006919057	NA	NA	NA	NA	4.06e-06	NA	NA
G62S	62	G	S	missense	wt-like	0.946492250031607	0.0960652918263718	6	0.0392184911610284	0.869625419827989	1.02335908023523	0.763026402740072	0.961104480197202	0.966574143962062	1.02304957853658	NA	NA	1.02381655950099	0.941382335252736	0.689856306775016	0.635804099035723	0.665129714518341	0.707734699768354	0.731970343287122	NA	NA	0.696335980363422	0.683376633186609	NA	NA	p.Gly62Ser	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.596	-2.537	0.941	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62T	62	G	T	missense	wt-like	1.07339731449283	0.10086306098154	6	0.0411771722166661	0.992691539962957	1.15410308902269	1.1583671683018	0.881042703598449	1.09240330851071	1.14500440182488	NA	NA	1.05923137143413	1.10433493328699	0.720018054494312	0.720011195773863	0.647819416126071	0.745384673609871	0.772362253033039	NA	NA	0.703620986887622	0.720024913214761	NA	NA	p.Gly62Thr	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.596	-3.074	1.478	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62V	62	G	V	missense	wt-like	0.961940501042874	0.0556720999431077	6	0.0227280396283071	0.917394361932193	1.00648664015356	0.977055910093477	1.02756522372987	0.86257783715645	0.961012145031785	NA	NA	0.992892752111304	0.950539138134359	0.68341406624835	0.681392120814647	0.679499309483594	0.676617444520808	0.711423305068959	NA	NA	0.689974796263045	0.685436011682052	NA	NA	p.Gly62Val	1	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.596	-3.394	1.798	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62W	62	G	W	missense	possibly_wt-like	0.768713028551903	0.113434138095505	6	0.0463092929577315	0.677948482205235	0.859477574898571	0.856132651024487	0.935796896064414	0.709701576821564	0.692288679176758	NA	NA	0.630548021807131	0.787810346417063	0.639856319929529	0.655635615386108	0.659657916969786	0.630874573833844	0.622421052540029	NA	NA	0.615438646550922	0.648838066025213	NA	NA	p.Gly62Trp	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.596	-5.876	4.28	0.006919057	NA	NA	NA	NA	NA	NA	NA
G62X	62	G	X	nonsense	low	0.0798120575968684	0.167004538965209	6	0.0681793175322522	-0.0538169492568661	0.213441064450603	0.263550950358667	0.20404681868417	0.103113129691957	-0.180012072368134	NA	NA	-0.0550449994142866	0.143218518628837	0.487926810483189	0.529416442105768	0.501444937866143	0.449374209837016	0.333511665623825	NA	NA	0.474408683100235	0.503868411698649	NA	NA	p.Gly62Ter	1	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G62Y	62	G	Y	missense	wt-like	0.912560960911853	0.172043742145133	6	0.070236563615756	0.774899825827115	1.05022209599659	0.655388029123098	0.755254089324402	1.06486825313701	1.05414384639577	NA	NA	1.03029149314924	0.915420054341596	0.687602792463471	0.612877257866126	0.620622437243793	0.737145771935025	0.742268885215346	NA	NA	0.697667907071386	0.677537677855556	NA	NA	p.Gly62Tyr	0	20.1	33	25.4	0.894	78.1	175	54.4	47.9	51.5463917525773	-1	0	0	19.32	0	0	0	0	5	25.1060579290246	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.596	-4.782	3.186	0.006919057	NA	NA	NA	NA	NA	NA	NA
L63A	63	L	A	missense	wt-like	0.985625532283751	0.120865056512742	6	0.049342952698145	0.888915122104524	1.08233594246298	0.874220177544399	0.953907889139063	1.01291997150468	0.991110289611498	NA	NA	1.20321926223554	0.878375603667332	0.695299126641286	0.659488236284567	0.663573726830885	0.721602066693201	0.721391927109511	NA	NA	0.73324002668019	0.669206326173062	NA	NA	p.Leu63Ala	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.341	-2.11	-0.231	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63C	63	L	C	missense	possibly_low	0.620205280495359	0.368186979934594	6	0.150311705129351	0.325599751987028	0.914810809003691	1.04572851209583	1.12817186823763	0.409278459143528	0.263374919185526	NA	NA	0.43510573717539	0.439572187134256	0.572876983197918	0.696019300563882	0.70125165012178	0.540983469791807	0.480363154252625	NA	NA	0.575235176846361	0.570518789549475	NA	NA	p.Leu63Cys	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.341	-3.233	0.892	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63D	63	L	D	missense	low	0.399634180590591	0.291239287214288	6	0.118897941121147	0.166598498157179	0.632669863024003	0.838954465216555	0.691593358307269	0.216106877676222	0.303600262021927	NA	NA	0.195335082833197	0.152215037488374	0.515902439316214	0.651976682940679	0.606858237939304	0.483183634473367	0.493685943573597	NA	NA	0.525913136551692	0.505891742080737	NA	NA	p.Leu63Asp	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.341	-2.728	0.387	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63E	63	L	E	missense	possibly_low	0.674148167228915	0.196833049977307	6	0.0803567561600236	0.516651819240802	0.831644515217028	0.797647551742624	0.714774086776594	0.538393457123942	0.797818697273742	NA	NA	0.341679080674681	0.854576129781908	0.62752427272275	0.64317836118423	0.611870184261271	0.579616614293301	0.65737300320115	NA	NA	0.556016839518275	0.663853789337212	NA	NA	p.Leu63Glu	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.341	-2.932	0.591	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63F	63	L	F	missense	wt-like	0.989900607359115	0.183730406539817	6	0.0750076243761108	0.842888365016029	1.1369128497022	0.720134945050911	0.790719779040201	1.13583676501354	1.10741300239089	NA	NA	1.10028404291259	1.08501510974656	0.713872793044224	0.626668271310649	0.628290536775795	0.758380615425459	0.759911835966949	NA	NA	0.712065729729149	0.715679856359299	NA	NA	p.Leu63Phe	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.341	-4.653	2.312	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63G	63	L	G	missense	wt-like	0.964753889929081	0.0529299860782544	6	0.0216085763307234	0.922401858563678	1.00710592129448	0.88534737631493	1.02550209212371	0.964420356979334	0.94650469697533	NA	NA	0.944737723051792	1.02201109412939	0.690789611298893	0.661858315934621	0.679053236148197	0.707090254389965	0.706618382092238	NA	NA	0.680069062426766	0.701510160171021	NA	NA	p.Leu63Gly	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.341	-2.736	0.395	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63H	63	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu63His	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.341	-4.292	1.951	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63I	63	L	I	missense	possibly_wt-like	0.86891500155577	0.230386894198325	6	0.094055055701745	0.684570479816441	1.0532595232951	1.18589241784045	1.11816687917749	0.645621988295296	0.809092568922244	NA	NA	0.795454353049591	0.659261802049541	0.65523383442029	0.725874040065545	0.699088453732692	0.611700999563975	0.661106953149459	NA	NA	0.649360715691121	0.619927308491897	NA	NA	p.Leu63Ile	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.341	-3.06	0.719	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63K	63	L	K	missense	wt-like	0.973654002234641	0.095034979374334	6	0.0387978678638404	0.89761157854457	1.04969642592471	0.911263938185834	1.10855956828712	0.980653136327872	1.00959850915848	NA	NA	1.00269943395057	0.829149427497964	0.694501660262494	0.667378511731992	0.697011240044404	0.711947345510612	0.727515297019523	NA	NA	0.691992080480583	0.658135286430627	NA	NA	p.Leu63Lys	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.341	-3.268	0.927	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63L	63	L	L	synonymous	wt-like	1.05339229677559	0.109769050863469	6	0.0448130273608521	0.965560377110115	1.14122421644107	0.904412836316646	0.941109607890279	1.08732912484551	1.18493269847725	NA	NA	1.06662945547159	1.13594005765229	0.716137881344969	0.665919235461704	0.660806587794801	0.743866401729524	0.785586659507541	NA	NA	0.705142810315097	0.727132952374841	NA	NA	p.Leu63=	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63M	63	L	M	missense	possibly_wt-like	0.735307410063246	0.190204368823892	6	0.0776506084111118	0.583115014199844	0.887499805926648	1.03159229563371	0.791198802094712	0.63903248075264	0.848125369003343	NA	NA	0.552709976917882	0.549185535977185	0.619061713621617	0.69300830384705	0.628394107198069	0.609729320045165	0.674034767691727	NA	NA	0.599426965734441	0.595170993636302	NA	NA	p.Leu63Met	1	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.341	-3.789	1.448	0.007692038	1.03514377	0.165025250847691	NA	NA	1.63e-05	NA	NA
L63N	63	L	N	missense	possibly_wt-like	0.730312030410052	0.248237311997436	6	0.101342458252298	0.531684462130795	0.92893959868931	0.658594387812051	0.858883209926175	0.80922216222404	0.964530450839723	NA	NA	0.265226005193262	0.82541596646506	0.650161949157792	0.613560208322587	0.643028272786708	0.660652626088551	0.712588581577268	NA	NA	0.540290053936899	0.657295625528877	NA	NA	p.Leu63Asn	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.341	-3.346	1.005	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63P	63	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu63Pro	1	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.341	-3.249	0.908	0.007692038	NA	NA	NA	NA	4.06e-06	NA	NA
L63Q	63	L	Q	missense	wt-like	1.19053561559622	0.176259206847283	6	0.0719575198739199	1.04950146822651	1.33156976296593	1.38327602656123	1.30884236511861	0.921451306490703	1.14551782117983	NA	NA	1.31403347989647	1.07009269433049	0.748174905764895	0.76791650591259	0.740314737959106	0.694233269821286	0.772532299511628	NA	NA	0.756035073570684	0.712323783087307	NA	NA	p.Leu63Gln	1	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.341	-3.089	0.748	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63R	63	L	R	missense	wt-like	0.904544779288626	0.0536356407131067	6	0.0218966586290598	0.8616281169939	0.947461441583351	0.916505919303275	0.989158261218326	0.904123797964993	0.923194202472873	NA	NA	0.83867124529319	0.855615249479096	0.669845159708642	0.668495047261609	0.671195272155675	0.689048619306664	0.698897856042603	NA	NA	0.658250649726197	0.664087488892204	NA	NA	p.Leu63Arg	1	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.341	-3.873	1.532	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63S	63	L	S	missense	wt-like	0.869598746659057	0.0929578636404269	6	0.0379498889163772	0.795218331165662	0.943979162152452	0.936765434709243	1.01187224326083	0.791480487835351	0.881613689171264	NA	NA	0.829020183234706	0.766840441742947	0.664537838204091	0.672810299120936	0.676106302406764	0.655344050934016	0.685126229015625	NA	NA	0.656265377287246	0.644121903485116	NA	NA	p.Leu63Ser	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.341	-2.182	-0.159	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63T	63	L	T	missense	wt-like	0.913990693066594	0.0940872328090166	6	0.0384109519487565	0.838706610635133	0.989274775498056	0.755973755357813	0.876014459427036	0.97388249217091	0.934207043458643	NA	NA	1.03168306757419	0.912183340410974	0.687381948551491	0.634301893819082	0.646732250556006	0.709921467199218	0.702545351624568	NA	NA	0.697954160992028	0.676809736110954	NA	NA	p.Leu63Thr	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.341	-2.618	0.277	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63V	63	L	V	missense	wt-like	0.927386951842159	0.115647416243784	6	0.0472128599780875	0.834851446677975	1.01992245700634	1.02629068966194	0.94538907711256	0.940722876322084	1.06716377179119	NA	NA	0.809628272277849	0.775127023887327	0.67680546385246	0.691879068296807	0.661731859408114	0.699999612645218	0.746581134926269	NA	NA	0.652276362800762	0.645985568051174	NA	NA	p.Leu63Val	1	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.341	-2.678	0.337	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63W	63	L	W	missense	wt-like	0.960876511354115	0.142722578784227	6	0.0582662487992547	0.846676762193326	1.0750762605149	1.08420439803762	0.727262925332826	1.03346959811388	0.940893167818593	NA	NA	0.878513659725178	1.10091531909659	0.704487219421657	0.704214616938562	0.614570418145222	0.727750823279678	0.704759821904752	NA	NA	0.666446436551915	0.719255836931536	NA	NA	p.Leu63Trp	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.341	-5.881	3.54	0.007692038	NA	NA	NA	NA	NA	NA	NA
L63X	63	L	X	nonsense	low	0.0845796560817008	0.133256999642068	6	0.0544019422962178	-0.0220461915079124	0.191205503671314	0.0739041284399474	0.15184258128107	-0.128821667789205	0.0572190225190936	NA	NA	0.278892197622841	0.0744416744164578	0.488711150080642	0.48902190233019	0.49015776731886	0.37997583872467	0.412083522933295	NA	NA	0.543101259067634	0.488400397831094	NA	NA	p.Leu63Ter	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L63Y	63	L	Y	missense	possibly_wt-like	0.774551157482498	0.147440066614367	6	0.0601921551411935	0.656576701253911	0.892525613711085	0.984166604207256	0.903697624717841	0.704163263806189	0.724565870966041	NA	NA	0.756941769576515	0.573771811621145	0.637274932648285	0.682906689913697	0.652717676710462	0.629217427488615	0.633111383454801	NA	NA	0.641438481841769	0.600700483349991	NA	NA	p.Leu63Tyr	0	22	31.3	22.6	0.411	33.1	-124.2	-75.5	158.8	8.37696335078534	-3.4	0	0	17.49	0	0	0	0	6	22.4719857764181	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.341	-4.737	2.396	0.007692038	NA	NA	NA	NA	NA	NA	NA
R64A	64	R	A	missense	low	0.351730585046919	0.326526255180779	6	0.13330378546912	0.0904599665245899	0.613001203569248	0.713533798287287	0.746039052059489	0.129013052803508	0.434952686566959	NA	NA	0.0371205795669897	0.049724340997281	0.515278992815754	0.625262235170365	0.618630037730215	0.457123855407222	0.537190375248169	NA	NA	0.493367610383339	0.482841433030148	NA	NA	p.Arg64Ala	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.615	-2.56	0.945	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64C	64	R	C	missense	possibly_wt-like	0.896891095250075	0.281596395684155	6	0.114961247138842	0.671571191240137	1.12221099926001	0.893403577195825	1.22284239080174	1.02025090979508	1.10231782629453	NA	NA	0.469420553043154	0.673111314370121	0.69264740407109	0.663574276811955	0.721720531330224	0.723795593415384	0.758224293912652	NA	NA	0.582293908598073	0.623042084272712	NA	NA	p.Arg64Cys	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.615	-3.972	2.357	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64D	64	R	D	missense	possibly_low	0.632170951692422	0.226620106296923	6	0.0925172709804578	0.450840432622792	0.813501470762051	0.824881318844996	0.884561663856634	0.690145954936265	0.627727645996986	NA	NA	0.501696556356816	0.264012570162832	0.613030713355289	0.64897912007555	0.648580256750493	0.625023238373762	0.601038188336817	NA	NA	0.58893324626162	0.531035172337975	NA	NA	p.Arg64Asp	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.615	-4.062	2.447	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64E	64	R	E	missense	low	0.382918788691628	0.402532382281848	6	0.164333156922911	0.0608317196569542	0.705005857726302	0.97027183153383	0.754935379498604	0.221764091678434	0.129625595095736	NA	NA	-0.0995224650615135	0.320438299404677	0.514300879990024	0.679947120426844	0.620553528428382	0.484876357777723	0.436064860166781	NA	NA	0.465259442719356	0.543725402202326	NA	NA	p.Arg64Glu	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.615	-3.064	1.449	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64F	64	R	F	missense	low	0.261920886175516	0.43117374334214	6	0.176025943612333	-0.0830836236493352	0.606925396000366	0.935699076973392	0.621424077830279	-0.0659720886051623	-0.158586775639022	NA	NA	0.0160025607686245	0.222958465724982	0.505412785177722	0.672583166234975	0.591686813638853	0.398781375745579	0.340607806870456	NA	NA	0.489023526754865	0.521802043600579	NA	NA	p.Arg64Phe	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.615	-4.728	3.113	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64G	64	R	G	missense	low	0.284300301980987	0.243501071165156	6	0.0994088960292944	0.0894624460206828	0.47913815794129	0.681832104798524	0.463206984097784	0.180442990598845	0.23048377243939	NA	NA	0.0246176339560047	0.125218325995372	0.495307916404823	0.618509813454942	0.557478415828831	0.47251246439633	0.469469479078589	NA	NA	0.49079569102599	0.499820141783656	NA	NA	p.Arg64Gly	1	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.615	-3.169	1.554	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64H	64	R	H	missense	wt-like	1.1138512834052	0.314301579565838	6	0.128313082547845	0.862362262866106	1.36534030394429	1.31125367742197	1.49996165482174	0.721994456659589	0.772572598033178	NA	NA	1.29970790335851	1.07761741013621	0.73329596846608	0.752575834143868	0.781636977782241	0.634552787910833	0.649011397366581	NA	NA	0.753088229782864	0.714016102788291	NA	NA	p.Arg64His	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.615	-3.646	2.031	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64I	64	R	I	missense	low	0.274766234318107	0.333604891572794	6	0.136193626674976	0.00783163111126101	0.541700837524953	0.673816366590042	0.611406017625949	-0.0217427339319821	0.338539827963684	NA	NA	-0.157580453141627	0.204158380802575	0.511415969922947	0.616802471077056	0.589520791114549	0.412015462234555	0.505258063117772	NA	NA	0.453316619960787	0.517573876728121	NA	NA	p.Arg64Ile	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.615	-3.8	2.185	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64K	64	R	K	missense	wt-like	1.16721967578669	0.201950781908033	6	0.0824460614717949	1.0056283646348	1.32881098693858	0.973723166918237	0.878749564742178	1.35885585919915	1.35928405560174	NA	NA	1.1672435098725	1.26546189838634	0.741051118780979	0.680682250618079	0.647323612516117	0.825111274349934	0.843332504166775	NA	NA	0.725839631863116	0.756262605698842	NA	NA	p.Arg64Lys	1	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.615	-2.148	0.533	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64L	64	R	L	missense	possibly_low	0.577883489043703	0.186050138046036	6	0.0759546507978601	0.429015109021581	0.726751869065825	0.750882699725924	0.856497684727462	0.425802629444102	0.541799430284831	NA	NA	0.389654942850742	0.502663547229158	0.578643280086904	0.633217505232227	0.642512494162172	0.545927749457026	0.572578430533978	NA	NA	0.565885717817461	0.58470812963983	NA	NA	p.Arg64Leu	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.615	-3.322	1.707	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64M	64	R	M	missense	low	0.316630941953042	0.472475738349815	6	0.192887412466963	-0.0614214395533282	0.694683323459413	0.77490320178936	1.04821481605941	0.111598186706767	-0.0219266661428045	NA	NA	0.0456937452181136	-0.0586976319125897	0.476794162606144	0.638333842623035	0.683963994381788	0.451913066196726	0.385870164354992	NA	NA	0.4951311540616	0.458457171150688	NA	NA	p.Arg64Met	1	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.615	-3.886	2.271	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64N	64	R	N	missense	wt-like	0.995005772902577	0.0275453833358018	6	0.0112453556570129	0.972965280821488	1.01704626498367	1.02480063651772	0.943536428293907	0.993366825160042	1.00922069366769	NA	NA	1.00187578512411	0.997234268651989	0.693880233627867	0.691561688810069	0.661331294928666	0.715751471952024	0.727390163065874	NA	NA	0.691822651737443	0.695937815518291	NA	NA	p.Arg64Asn	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.615	-3.62	2.005	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64P	64	R	P	missense	low	0.289040607487566	0.245713579617776	6	0.100312148822713	0.0924324085832255	0.485648806391906	-0.0689930423850843	0.149732833507424	0.384428905051223	0.669766284618517	NA	NA	0.298105966367549	0.301202697765765	0.536473698683864	0.458584980728714	0.489701615019402	0.533548110390792	0.614961548243854	NA	NA	0.547053628797111	0.539399286976936	NA	NA	p.Arg64Pro	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.615	-3.258	1.643	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64Q	64	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg64Gln	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.615	-2.661	1.046	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64R	64	R	R	synonymous	wt-like	1.18708876185591	0.252183114089385	6	0.102953325210845	0.985303952354013	1.3888735713578	0.916576474181457	0.827461646563111	1.37121539147242	1.28368404597565	NA	NA	1.28698607758498	1.43660893535784	0.772612556407517	0.668510075363869	0.636234560969741	0.828809431835529	0.818293488215855	NA	NA	0.750471285665391	0.794753827149643	NA	NA	p.Arg64=	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64S	64	R	S	missense	wt-like	0.928256890099648	0.0863924283539395	6	0.0352695611845176	0.859129820427462	0.997383959771834	0.901170454695657	0.970996586996141	0.820286180241128	1.04130621756387	NA	NA	0.988972494138939	0.846809406962154	0.666248558299509	0.665228612165033	0.667268504433984	0.663963146272164	0.738017012832211	NA	NA	0.689168379305103	0.662107041901252	NA	NA	p.Arg64Ser	1	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.615	-2.549	0.934	0.007260995	1.087859425	0.0749999998741476	NA	NA	1.63e-05	NA	NA
R64T	64	R	T	missense	wt-like	0.963732185856555	0.0889075573242267	6	0.0362963582869335	0.892592630844203	1.03487174086891	1.06006850103989	1.02867613851642	0.860927508581473	1.01059992975412	NA	NA	0.848970382568309	0.97315065467911	0.685130438746216	0.699073700568701	0.679739502335421	0.67612364145138	0.727846971398823	NA	NA	0.660369234525815	0.690521375157012	NA	NA	p.Arg64Thr	1	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.615	-2.428	0.813	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64V	64	R	V	missense	possibly_low	0.615712187585664	0.149425781244382	6	0.061002819744246	0.496148857931553	0.735275517239775	0.737522216586043	0.806053036292137	0.492587384768012	0.702152933580213	NA	NA	0.477595169130376	0.478362385157203	0.604831800203318	0.630371738758765	0.631605767459304	0.56591075021823	0.625688131798004	NA	NA	0.583975468608632	0.579242762389685	NA	NA	p.Arg64Val	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.615	-3.573	1.958	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64W	64	R	W	missense	low	0.248705018588395	0.437954672561076	6	0.17879424637372	-0.101725264947078	0.599135302123867	0.587889538283815	0.86390838573038	0.290023704030565	0.207108077929746	NA	NA	-0.169613007508105	-0.287086586936034	0.483514008211531	0.598500162350297	0.644114774939669	0.505300657888977	0.461727358534085	NA	NA	0.450841462469395	0.407092157766385	NA	NA	p.Arg64Trp	1	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.615	-5.821	4.206	0.007260995	NA	NA	NA	NA	NA	NA	NA
R64X	64	R	X	nonsense	low	0.132834976365249	0.0494092855674017	2	0.0349376408782923	0.0643584585390016	0.201311494191496	0.0978973354869565	0.167772617243541	NA	NA	NA	NA	NA	NA	0.493867227249743	0.494132425916077	0.493602028583408	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg64Ter	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R64Y	64	R	Y	missense	low	0.429498651498003	0.196505780749574	6	0.0802231490572804	0.272264168619345	0.586733134376661	0.649795611819901	0.679520995218149	0.237815808348381	0.36637994997438	NA	NA	0.416819872549746	0.226659671077458	0.54705406592745	0.61168607986003	0.604248050953075	0.489679272228461	0.514478819339222	NA	NA	0.571473681702749	0.52263445015215	NA	NA	p.Arg64Tyr	0	20.2	29.3	19.9	0.961	32.3	-167.4	-100.7	126.1	30.188679245283	-3.9	0	1	15.24	2	81	0	0	8	19.574383520052	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.615	-4.667	3.052	0.007260995	NA	NA	NA	NA	NA	NA	NA
V65A	65	V	A	missense	possibly_low	0.716125310628214	0.130287952171411	6	0.053189833742016	0.61187515215019	0.820375469106239	0.877841889567294	0.880553191548701	0.682573646999626	0.650667345025953	NA	NA	0.587059549564439	0.618056241063272	0.616708803592591	0.660259656490212	0.647713577859575	0.622757490232168	0.608635905489718	NA	NA	0.606492847131922	0.610660116953014	NA	NA	p.Val65Ala	1	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.195	-2.909	1.714	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65C	65	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val65Cys	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.195	-3.594	2.399	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65D	65	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val65Asp	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.195	-4.333	3.138	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65E	65	V	E	missense	low	-0.198462438264161	0.274532834368394	6	0.112077560307096	-0.418130419941185	0.021205543412862	0.083154570267152	0.174832063781174	-0.324925626102911	-0.255093757107754	NA	NA	-0.552011864736149	-0.316730015686481	0.386302691967058	0.490992235059999	0.495128364011401	0.321298592259487	0.308644320882528	NA	NA	0.372180077086012	0.400425306848104	NA	NA	p.Val65Glu	1	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.195	-4.182	2.987	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65F	65	V	F	missense	possibly_low	0.584578997956724	0.676749596749202	4	0.338374798374601	-0.0786234201334959	1.24778141604694	-0.0958943605938243	0.113814700172605	NA	NA	NA	NA	1.27559488772858	1.04480076451954	0.594285641280451	0.452855033042778	0.481935691851907	NA	NA	NA	NA	0.748128060108272	0.706635590708996	NA	NA	p.Val65Phe	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.195	-2.595	1.4	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65G	65	V	G	missense	low	0.118520831129887	0.189394057937751	6	0.0773198003771005	-0.0330231929010563	0.270064855160831	0.350109602718253	0.355792370517128	0.0283534493529261	0.0725964539721288	NA	NA	-0.00420142699109275	-0.0915254627900203	0.467970803719469	0.547853328578657	0.534254112150307	0.427004991863892	0.417176587779994	NA	NA	0.484867463949215	0.451074143489723	NA	NA	p.Val65Gly	1	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.195	-4.03	2.835	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65H	65	V	H	missense	low	-0.0454522565154864	0.43225224482067	6	0.176466239997206	-0.391319731397211	0.300415218366239	0.730628523814037	-0.0622615313167751	-0.0475302150857227	-0.0104365436153102	NA	NA	-0.532655494233252	-0.350458278655896	0.398569615832264	0.62890339067857	0.443865938264711	0.404299460985087	0.389675737431859	NA	NA	0.376161780720769	0.392839770679442	NA	NA	p.Val65His	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.195	-5.255	4.06	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65I	65	V	I	missense	possibly_wt-like	0.908442582555739	0.260432229915949	6	0.106321012644878	0.70005722697195	1.11682793813953	0.922428924989648	0.960584822727535	1.11063040551796	1.24376598804973	NA	NA	0.587939955937726	0.625305398111835	0.667386999321956	0.66975664018665	0.665017358457261	0.750838494494652	0.805072472847201	NA	NA	0.606673951190456	0.612290463082433	NA	NA	p.Val65Ile	1	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.195	-1.607	0.412	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65K	65	V	K	missense	low	0.0329560406110585	0.299794491047791	6	0.122390588460745	-0.206925104818664	0.272837186040781	0.180290998702048	0.558444017035947	-0.154031566321341	0.0261243091197425	NA	NA	-0.1765022819858	-0.236589232884245	0.433936695521383	0.51168217482473	0.578069783247721	0.372432658861028	0.401784833440444	NA	NA	0.449424303750276	0.41844908729249	NA	NA	p.Val65Lys	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.195	-4.179	2.984	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65L	65	V	L	missense	possibly_low	0.580764706242253	0.201597040956591	6	0.0823016473331017	0.419456441601057	0.74207297088345	0.769465321251031	0.841304844489581	0.498154238363951	0.564940566556861	NA	NA	0.53008208108207	0.280641185710027	0.587507578609734	0.637175580757753	0.639227623289747	0.567576436333357	0.580242864481851	NA	NA	0.594772292737617	0.534774972540031	NA	NA	p.Val65Leu	1	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.195	-2.722	1.527	0.005503188	NA	NA	NA	NA	4.06e-06	NA	NA
V65M	65	V	M	missense	low	0.446380833445176	0.127173998010709	6	0.0519185672793265	0.344622311448776	0.548139355441575	0.425026504298746	0.511728350091601	0.572352508700192	0.497791859485069	NA	NA	0.464386760133514	0.206999017961931	0.565889921344152	0.563810536456642	0.567969306231662	0.58977767201084	0.558002952664776	NA	NA	0.581258431852992	0.51821274022174	NA	NA	p.Val65Met	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.195	-3.719	2.524	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65N	65	V	N	missense	low	0.210895675098367	0.519422518083148	4	0.259711259041574	-0.298129039002671	0.719920389199404	0.864707171740996	0.0235297793359463	NA	0.322664219149929	NA	NA	-0.367318469833405	NA	0.481207514676763	0.65746197775082	0.462415029353525	NA	0.5	NA	NA	0.41017244562896	NA	NA	NA	p.Val65Asn	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.195	-4.511	3.316	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65P	65	V	P	missense	low	-0.148638004029583	0.0708589093882972	6	0.0289280286219061	-0.205335898272263	-0.0919401097869034	-0.165464370262178	-0.118646836059633	-0.161030137592425	-0.0556249742978746	NA	NA	-0.268741033974513	-0.122320671990875	0.431062548078747	0.438036706564625	0.431674771749263	0.370338581337511	0.374709154196566	NA	NA	0.430450324408231	0.444148255446617	NA	NA	p.Val65Pro	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.195	-4.412	3.217	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65Q	65	V	Q	missense	low	0.0288349447118293	0.248321949845918	6	0.101377011509249	-0.169860346706601	0.22753023613026	0.35896959398085	0.0269437214140235	0.246468841362353	-0.166230671365797	NA	NA	-0.308399453989672	0.0152576368692178	0.469121492082698	0.549740495818515	0.46315316381139	0.492268389527256	0.338076119004588	NA	NA	0.42229238616772	0.475089820354005	NA	NA	p.Val65Gln	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.195	-4.609	3.414	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65R	65	V	R	missense	low	-0.0781978589172695	0.027183076452926	6	0.0110974444914555	-0.0999484504409548	-0.0564472673935843	-0.0526967588271982	-0.0497052364123025	-0.0921700088498054	-0.101006025496427	NA	NA	-0.0606427723290372	-0.112966351588846	0.446416406464638	0.46205606907975	0.446580757005083	0.390942564962315	0.359678774300451	NA	NA	0.473257192806232	0.446252055924193	NA	NA	p.Val65Arg	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.195	-4.529	3.334	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65S	65	V	S	missense	low	0.0166068110202585	0.177242129057456	6	0.0723587961858819	-0.125213823468744	0.158427445509261	0.264127345410157	0.206258153785465	-0.135590212585262	-0.0867673016465432	NA	NA	-0.143114743023047	-0.0052723758192177	0.463382440054289	0.529539213542686	0.501923054541477	0.377950588573556	0.364394694779315	NA	NA	0.456292289937236	0.470472590171341	NA	NA	p.Val65Ser	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.195	-3.967	2.772	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65T	65	V	T	missense	low	0.476399716718288	0.296889048393984	6	0.121204446464287	0.238843366882173	0.713956066554403	0.67342288924988	0.994345997544603	0.250716457566552	0.338907211344185	NA	NA	0.269579315757398	0.331426428847109	0.543691100378588	0.616718660887636	0.672316921806773	0.493539340022323	0.505379741916095	NA	NA	0.541185552010459	0.546196648746718	NA	NA	p.Val65Thr	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.195	-3.105	1.91	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65V	65	V	V	synonymous	wt-like	1.00277856556926	0.119522207583261	6	0.0487947369183335	0.907142638574224	1.09841449256431	0.83917529714558	0.967420389457488	1.08835377419169	0.913356093901281	NA	NA	1.16552776333909	1.04283807538046	0.700916807703763	0.652023719869907	0.666495288435867	0.744172992186663	0.695639436385392	NA	NA	0.725486694094777	0.706194179022133	NA	NA	p.Val65=	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65W	65	V	W	missense	possibly_low	0.586854237684912	0.196320417417743	6	0.0801474747939456	0.429768073636947	0.743940401732877	0.688150313991534	0.835600129910324	0.436775128533527	0.757821218668985	NA	NA	0.404938731135133	0.397839903869969	0.594442627432313	0.619855584240739	0.63799419685575	0.549210885804428	0.644125683396107	NA	NA	0.569029670623888	0.561133137392139	NA	NA	p.Val65Trp	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.195	-3.998	2.803	0.005503188	NA	NA	NA	NA	NA	NA	NA
V65X	65	V	X	nonsense	low	0.386590734916335	0.124297111195487	6	0.0507440831551543	0.287134159503727	0.486047310328943	0.23104651598088	0.366779461402816	0.415657988243134	0.328524795327419	NA	NA	0.371367877677775	0.606167770865987	0.539760985561571	0.52249303756847	0.536629650512982	0.54289232061016	0.501941045525199	NA	NA	0.562123975715172	0.607986382442781	NA	NA	p.Val65Ter	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V65Y	65	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val65Tyr	0	21.7	25.8	19.9	0.94	6.6	-153.6	-123	128.6	0	-6.3	0	1	12.58	0	0	0	0	7	16.3597215804574	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.195	-4.235	3.04	0.005503188	NA	NA	NA	NA	NA	NA	NA
F66A	66	F	A	missense	low	0.313073418739832	0.170432228590519	6	0.0695786659620257	0.176701739361918	0.449445098117745	0.572372402820234	0.45164942681069	0.286408746295945	0.229171804464173	NA	NA	0.0995162126821897	0.239321919365758	0.515842458617403	0.595195031584883	0.554979535916035	0.504219008299751	0.469034950204571	NA	NA	0.506202708736648	0.525482208498158	NA	NA	p.Phe66Ala	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.161	-3.591	2.43	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66C	66	F	C	missense	possibly_wt-like	0.746596598435906	0.106633753223497	6	0.0435330474592381	0.661273393278527	0.831919803593286	0.845319031194359	0.916298953243853	0.670500274025603	0.679824393683869	NA	NA	0.693236901882666	0.674400036585089	0.62583299354736	0.653332327664612	0.655442232249837	0.619144955902139	0.618292832916555	NA	NA	0.628334067292029	0.62333191980269	NA	NA	p.Phe66Cys	1	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.161	-3.846	2.685	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66D	66	F	D	missense	low	-0.360480299070451	0.174185516934496	6	0.0711109395120722	-0.499855179420919	-0.221105418719984	-0.411715654187689	-0.0407005469764321	-0.464615658798198	-0.329620405397093	NA	NA	-0.368791373948777	-0.547438155114519	0.367062095739188	0.385585486013303	0.448527676842321	0.279501238714595	0.283960806362955	NA	NA	0.409869461778297	0.348538705465073	NA	NA	p.Phe66Asp	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.161	-4.398	3.237	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66E	66	F	E	missense	low	0.318712487435633	0.237431248063125	6	0.0969309011244721	0.128731412242655	0.508693562628612	-0.0688681048728349	0.22296372249241	0.494923794462406	0.534173276936063	NA	NA	0.507382188578902	0.221700047016853	0.544064431212943	0.458611592265132	0.505534995113057	0.566609839051829	0.570052619012413	NA	NA	0.590102809660977	0.521519023374056	NA	NA	p.Phe66Glu	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.161	-4.276	3.115	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66G	66	F	G	missense	low	0.114460826880872	0.302475751490386	6	0.123485208452722	-0.127565734309885	0.356487388071628	0.553639130080305	0.427797930176991	-0.0197346741695782	0.00655387853074911	NA	NA	-0.197698015557826	-0.0837932877754103	0.448938677435885	0.591204867535922	0.549822561622287	0.412616303842285	0.395303031042431	NA	NA	0.445064233798502	0.452813121073269	NA	NA	p.Phe66Gly	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.161	-4.056	2.895	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66H	66	F	H	missense	low	0.379077615299843	0.290966793444251	3	0.167989756520281	0.0498237427484394	0.708331487851246	0.344238612559593	0.107098848182959	NA	NA	NA	NA	NA	0.685895385156975	0.546602814897032	0.546602814897032	0.480483645609144	NA	NA	NA	NA	NA	0.625917240678612	NA	NA	p.Phe66His	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.161	-4.985	3.824	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66I	66	F	I	missense	possibly_wt-like	0.860143441894659	0.247403409763943	6	0.10100201909106	0.662183122110354	1.05810376167896	1.15976060068593	0.981271136767374	0.781837662935271	0.992135351898525	NA	NA	0.441953038908911	0.803902860171948	0.66097437803726	0.720307995157558	0.669489983021421	0.6524587730531	0.721731431708551	NA	NA	0.576643701559016	0.652457296142194	NA	NA	p.Phe66Ile	1	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.161	-3.134	1.973	0.0060714	NA	NA	NA	NA	4.06e-06	NA	NA
F66K	66	F	K	missense	low	0.0919163997888827	0.0734090732717585	6	0.0299691286677319	0.0331779869520814	0.150654812625684	0.20305172113142	0.0498361564594791	0.0684326378257033	0.163559364727796	NA	NA	0.0217149001170089	0.0449036184718888	0.474930011557276	0.516530180703195	0.46810277770203	0.438997286360975	0.447303856078215	NA	NA	0.490198583945624	0.481757245412523	NA	NA	p.Phe66Lys	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.161	-4.193	3.032	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66L	66	F	L	missense	wt-like	0.833201827749165	0.105465504595168	6	0.043056111953886	0.748813399005223	0.917590256493106	0.896946866929764	0.965090474265902	0.663524985629589	0.767730329427317	NA	NA	0.865193663355351	0.840724646887064	0.662222508039374	0.664328993166524	0.665991533349378	0.617057844964154	0.647407619252524	NA	NA	0.663706445707414	0.660738570371334	NA	NA	p.Phe66Leu	1	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.161	-1.356	0.195	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66M	66	F	M	missense	wt-like	1.06170960565225	0.0690215204378945	6	0.028177917723987	1.0064819017539	1.11693730955059	1.0178637330962	1.07971614452397	0.997574016048939	1.08002161315914	NA	NA	1.01222791914605	1.18285420793918	0.705481232411531	0.690084136914683	0.690774952352497	0.717010326586254	0.750839701779616	NA	NA	0.693952138236809	0.737684014080744	NA	NA	p.Phe66Met	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.161	-3.646	2.485	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66N	66	F	N	missense	low	0.161699125581828	0.107477007856514	6	0.043877304721593	0.0757011885888168	0.24769706257484	0.0167667822912056	0.242540066578504	0.228734790262747	0.290971765088151	NA	NA	0.0839707783634412	0.107210570906921	0.492636753773177	0.476851717887735	0.509767631109362	0.486962095375186	0.489503336484989	NA	NA	0.503004934013253	0.495770171061366	NA	NA	p.Phe66Asn	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.161	-4.509	3.348	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66P	66	F	P	missense	low	-0.10822816956813	0.0701132658300316	6	0.0286236209139488	-0.164329435666597	-0.0521269034696629	-0.139498670252029	-0.135519095184628	-0.08611422076701	0.0230399283047086	NA	NA	-0.173539542823779	-0.137737416686042	0.434353898768455	0.443567368725208	0.428026790747429	0.392754547611369	0.400763274570169	NA	NA	0.45003375423008	0.440681006789482	NA	NA	p.Phe66Pro	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.161	-4.604	3.443	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66Q	66	F	Q	missense	low	-0.156825933823795	0.113142217451244	6	0.0461901168537609	-0.247356899298863	-0.0662949683487274	-0.345895431750695	-0.0771619249273734	-0.180561218857682	-0.0828129653038641	NA	NA	-0.211294303215674	-0.0432297588874838	0.420124705109515	0.399605112423958	0.440644297795072	0.364494588799126	0.365704386289268	NA	NA	0.442267408434038	0.461935918644758	NA	NA	p.Phe66Gln	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.161	-4.61	3.449	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66R	66	F	R	missense	low	-0.0474021449599629	0.0892489656197114	6	0.0364357376399153	-0.118814878484347	0.0240105885644214	0.0471543208662453	0.0744516633422366	-0.0804315259414681	-0.130910180338415	NA	NA	-0.135976558091825	-0.0587005895965511	0.458108578381458	0.483324226223137	0.473424940003687	0.394454895160353	0.349774402412263	NA	NA	0.457760650799722	0.458456505963195	NA	NA	p.Phe66Arg	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.161	-4.444	3.283	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66S	66	F	S	missense	low	0.142824720045639	0.0653289986096505	6	0.0266704520001059	0.0905515946740268	0.19509784541725	0.149093797627161	0.167633035757517	0.163041916077942	0.219542655505807	NA	NA	0.134481086708511	0.0231558285968932	0.485218992382447	0.505037209372863	0.493571849423317	0.46730580183224	0.465845738780462	NA	NA	0.513395160750242	0.476866135341576	NA	NA	p.Phe66Ser	1	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.161	-4	2.839	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66T	66	F	T	missense	low	-0.0530489957112416	0.167877305976595	6	0.0685356231726236	-0.187376348787593	0.0812783573651094	-0.187873081926728	-0.217921626953493	-0.117298488203352	-0.109208164794761	NA	NA	0.153308003803436	0.160699383807448	0.421737036041886	0.433263678546043	0.410210393537729	0.383423746938435	0.356962194001871	NA	NA	0.517267953132312	0.507799884101841	NA	NA	p.Phe66Thr	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.161	-3.937	2.776	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66V	66	F	V	missense	low	0.279944416348686	0.185257660890692	6	0.0756311233539589	0.13171013846462	0.428178694232751	0.534168440623528	0.466517239565942	0.203374454411744	0.27966528917792	NA	NA	0.0920245590121706	0.10391651530081	0.49984548532509	0.587057634633402	0.558194132021286	0.479373902408736	0.485758587878935	NA	NA	0.504661637560944	0.495029333089235	NA	NA	p.Phe66Val	1	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.161	-3.476	2.315	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66W	66	F	W	missense	low	0.0544848316869693	0.131263025274232	6	0.0535879056693201	-0.050545533431828	0.159515196805767	-0.0114078552378353	-0.0696328314128229	0.041605783431269	0.275961243750462	NA	NA	-0.0470378978296076	0.137420547420351	0.473453169640262	0.470850554752942	0.442272176427011	0.430970289044227	0.48453179368936	NA	NA	0.476055784527582	0.502564439408504	NA	NA	p.Phe66Trp	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.161	-3.802	2.641	0.0060714	NA	NA	NA	NA	NA	NA	NA
F66X	66	F	X	nonsense	low	-0.145862828785945	0.427201103557038	6	0.174404120211437	-0.487688623155754	0.195962965583865	-0.0416784088415031	0.668074829270415	-0.271053050770847	-0.313963535511609	NA	NA	-0.461243871046107	-0.455312935816015	0.380054658682441	0.464402964072534	0.601773255158875	0.337418075046351	0.289146422300612	NA	NA	0.390851513982778	0.369257803382105	NA	NA	p.Phe66Ter	0	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F66Y	66	F	Y	missense	low	0.252227557580315	0.301123120173641	6	0.122932999030033	0.0112833069699531	0.493171808190678	0.504793022740516	0.568152025126692	0.320059087791586	0.354915111018984	NA	NA	-0.145250785509854	-0.0893031156860328	0.512484657804478	0.580800706760347	0.580168768855892	0.514287695329611	0.510681620279344	NA	NA	0.455852895158528	0.451573952636488	NA	NA	p.Phe66Tyr	1	21.2	23.2	17.1	0.901	5.5	-165.7	-107.3	137.5	0	-5.6	0	1	12.19	0	0	0	0	7	12.9925118017016	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.161	-3.067	1.906	0.0060714	NA	NA	NA	NA	NA	NA	NA
F67A	67	F	A	missense	possibly_low	0.702115927622217	0.110295688542636	6	0.0450280262930658	0.613862617792886	0.790369237451549	0.829755515040862	0.857629627748134	0.622048317771383	0.642865089700888	NA	NA	0.636663987008061	0.623733028463975	0.61431678322674	0.6500173178693	0.642757233565709	0.604647403668639	0.606051768311645	NA	NA	0.616696731627716	0.611936834825764	NA	NA	p.Phe67Ala	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.931	-2.913	0.982	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67C	67	F	C	missense	possibly_low	0.621931385240117	0.139779381823189	6	0.0570646936714125	0.510086640855338	0.733776129624897	0.63516939779262	0.609358805294613	0.705736443307049	0.785482338126664	NA	NA	0.626038856919917	0.369802469999841	0.61154090135841	0.608570714264585	0.589078159713733	0.629688146397605	0.653287153278806	NA	NA	0.614511088452235	0.554827477094981	NA	NA	p.Phe67Cys	1	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.931	-5.092	3.161	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67D	67	F	D	missense	low	0.328142749994918	0.132400327178679	6	0.054052207227552	0.22220237054402	0.434083129445815	0.194948318074662	0.212328589291845	0.342221533142909	0.409911658829812	NA	NA	0.542349613735159	0.267096786895118	0.524907860685222	0.514804165820467	0.503235554144291	0.520919031480768	0.528896689889675	NA	NA	0.597295786454944	0.531728817237387	NA	NA	p.Phe67Asp	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.931	-4.374	2.443	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67E	67	F	E	missense	low	-0.0763641613448656	0.116885753527682	6	0.0477184090572567	-0.169890524496639	0.0171622018069074	0.0556656078611273	0.0864669806759587	-0.125701150022605	-0.126156595243452	NA	NA	-0.186410286827438	-0.162049524512785	0.441299677349954	0.485137119882929	0.476022793026196	0.380909544457407	0.351348808204082	NA	NA	0.447386176876994	0.435213177822915	NA	NA	p.Phe67Glu	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.931	-4.187	2.256	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67G	67	F	G	missense	low	0.0577487036331347	0.0230304333351246	6	0.0094021350377066	0.0393208575814476	0.0761765496848218	0.028498659221631	0.0486647247543418	0.0624793160295783	0.0711814902532667	NA	NA	0.0422637690382014	0.0934042625017889	0.473600046811076	0.479350593242005	0.467849500380148	0.43721596316219	0.416707946316828	NA	NA	0.49442559055626	0.49266511190496	NA	NA	p.Phe67Gly	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.931	-4.033	2.102	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67H	67	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe67His	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.931	-5.199	3.268	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67I	67	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe67Ile	1	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.931	-2.356	0.425	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67K	67	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe67Lys	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.931	-4.152	2.221	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67L	67	F	L	missense	possibly_low	0.697223226329304	0.121924698759975	6	0.0497755498340811	0.599664941343827	0.794781511314782	0.869937516596458	0.829559241483397	0.572646612953094	0.619378174025854	NA	NA	0.637553960223333	0.65426385269369	0.617841532966238	0.65857603477095	0.636688085679269	0.58986567241574	0.598272810886458	NA	NA	0.616879803634193	0.618803262298284	NA	NA	p.Phe67Leu	1	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.931	-1.764	-0.167	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67M	67	F	M	missense	possibly_wt-like	0.752399450926821	0.166759625225054	6	0.0680793319165227	0.618966412278888	0.885832489574753	0.851414881606693	1.02370695809771	0.756056923180293	0.565065402676041	NA	NA	0.698485590801927	0.619666949198261	0.637079269084022	0.654630736303659	0.678665107043845	0.644744788931282	0.580284210687955	NA	NA	0.629413749236762	0.611022367592077	NA	NA	p.Phe67Met	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.931	-3.675	1.744	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67N	67	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe67Asn	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.931	-4.529	2.598	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67P	67	F	P	missense	low	0.103169109101183	0.105157659368455	6	0.0429304346663528	0.0190270033144821	0.187311214887885	-0.0024615598548577	0.10928588204937	0.15671534142007	0.282196232054221	NA	NA	0.0238899895691158	0.0493887693691827	0.481861235273365	0.472756104664275	0.480956508071481	0.465412795777326	0.486596845960699	NA	NA	0.490646010883235	0.482765962475248	NA	NA	p.Phe67Pro	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.931	-4.441	2.51	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67Q	67	F	Q	missense	low	0.224907320466764	0.0833920044911261	6	0.034044643271857	0.15818104578741	0.291633595146117	0.290206994882724	0.255196159124228	0.0841051106750365	0.184544056041317	NA	NA	0.220401471026575	0.314990131050703	0.521786723537372	0.535094146798589	0.512504027274347	0.443686725370809	0.454254067104949	NA	NA	0.531069419800397	0.542500101090925	NA	NA	p.Phe67Gln	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.931	-4.586	2.655	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67R	67	F	R	missense	low	0.0186858378914657	0.0285358275330074	6	0.0116497028073219	-0.00414716004148033	0.0415188358244118	0.0237897917915966	0.0379173548224396	-0.0142210963306529	0.0141670621485146	NA	NA	-0.0100295221304667	0.0604914370473633	0.471936701390544	0.478347610271998	0.465525792509091	0.41426604905162	0.397824546938862	NA	NA	0.483668595204856	0.485262968838067	NA	NA	p.Phe67Arg	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.931	-4.495	2.564	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67S	67	F	S	missense	low	0.304722841252033	0.191733276376265	8	0.0677879499523857	0.171860900759553	0.437584781744512	0.454093045109805	0.283479015589781	0.521988934262755	0.283291381549188	0.341763773719979	0.38737091681282	-0.117463740847644	0.283259403819575	0.544901276812886	0.570001673893335	0.518619113718882	0.574708134937011	0.486959563714424	0.555957246952789	0.554438739965004	0.461568831248619	0.535363813660768	ND	*35	p.Phe67Ser	1	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.931	-3.992	2.061	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67T	67	F	T	missense	possibly_low	0.535322032679189	0.309416014361694	6	0.126318558905304	0.287742206645792	0.782901858712586	0.83489615125017	1.01479912960079	0.330712976040098	0.412495474593908	NA	NA	0.301805280712636	0.31722318387753	0.545408457250167	0.651112267058155	0.676739129681619	0.517475498533309	0.529752459676629	NA	NA	0.547814596529762	0.543002317970573	NA	NA	p.Phe67Thr	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.931	-3.773	1.842	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67V	67	F	V	missense	wt-like	0.852959572173681	0.0591644721361115	6	0.0241537946057644	0.805619004656405	0.900300139690957	0.874351877978087	0.906449569752006	0.792499468583536	0.930178737327069	NA	NA	0.793609851496383	0.820667927905007	0.655938364952011	0.659516288314932	0.653312679616022	0.655648945261589	0.701211161034083	NA	NA	0.648981292361855	0.656227784642433	NA	NA	p.Phe67Val	1	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.931	-1.256	-0.675	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67W	67	F	W	missense	low	0.223184113949914	0.146365921599379	6	0.0597536372751143	0.10606913694542	0.340299090954408	0.190793599211858	0.509496016604604	0.211920395207528	0.194273089437223	NA	NA	0.104379085305391	0.128242497932881	0.503851654415753	0.513919215813597	0.567486649458198	0.48193097610915	0.457476360641576	NA	NA	0.507203026311488	0.500500282520018	NA	NA	p.Phe67Trp	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.931	-5.424	3.493	0.005822716	NA	NA	NA	NA	NA	NA	NA
F67X	67	F	X	nonsense	low	0.123427823632543	0.152321736401045	6	0.062185088486214	0.00154728982412697	0.245308357440958	-0.0149574481293984	0.242557470663895	0.167401633554221	0.312655433801811	NA	NA	0.121431148434216	-0.0885212965294878	0.483389773683504	0.470094495833553	0.509771394077462	0.468610294709762	0.496685051533454	NA	NA	0.51071072222638	0.451749784919779	NA	NA	p.Phe67Ter	0	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F67Y	67	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe67Tyr	1	21.3	19.3	17.6	0.9	13.5	-155.3	-118.1	95.1	1.75438596491228	-5.2	0	1	10.91	0	0	0	0	6	9.47187987528879	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.931	-4.094	2.163	0.005822716	NA	NA	NA	NA	NA	NA	NA
P68A	68	P	A	missense	possibly_low	0.601361495409664	0.203456213348747	6	0.0830606512838768	0.438565610360825	0.764157380458503	0.701958790554741	0.920254965866762	0.632286685506468	0.578512978586327	NA	NA	0.353858990677232	0.421296561266453	0.596224488403086	0.622796772762272	0.656297568739425	0.607710876900687	0.584738099905486	NA	NA	0.558522308811752	0.566408574293182	NA	NA	p.Pro68Ala	1	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-0.604	-3.355	2.751	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68C	68	P	C	missense	low	0.39648840806914	0.0959984528494095	6	0.0391912042629472	0.319675059203011	0.473301756935269	0.33756716939651	0.42648186698161	0.369114932566546	0.556042160094664	NA	NA	0.416171166176292	0.273553153199219	0.547359909490052	0.545181805710139	0.549538013269965	0.528965940068625	0.57729567780229	NA	NA	0.571340239509923	0.533180863557184	NA	NA	p.Pro68Cys	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-0.604	-5.317	4.713	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68D	68	P	D	missense	low	0.0956746436128916	0.102230351789297	6	0.0417353663515	0.0138748286823668	0.177474458543416	0.0379827842076885	0.0531483722202146	0.00107546043804253	0.081990802329702	NA	NA	0.29005227293313	0.109798169548571	0.475094808964999	0.481370700197185	0.468818917732813	0.418843008330277	0.42028803233585	NA	NA	0.545396943189845	0.496352125818538	NA	NA	p.Pro68Asp	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-0.604	-3.789	3.185	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68E	68	P	E	missense	low	-0.00537216622801747	0.194336358311107	6	0.0793374860554821	-0.160870781520711	0.150126449064676	-0.137424815839389	0.087226752832587	-0.150673486918764	-0.219705944424743	NA	NA	0.28398663922496	0.104357857757244	0.4600980809363	0.444009097163959	0.476187064708641	0.373437446599374	0.320364901483252	NA	NA	0.544149211556515	0.495128591659684	NA	NA	p.Pro68Glu	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-0.604	-3.752	3.148	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68F	68	P	F	missense	low	-0.0553457039167678	0.816471443719616	6	0.333323071111096	-0.708646918510798	0.597955510677263	0.815744315799005	1.13976322485887	-0.451815266640591	-0.425922545296477	NA	NA	-0.766691473567674	-0.643152478653738	0.327515902438724	0.647032949666593	0.703757837848421	0.283331308091784	0.252065164696048	NA	NA	0.328019392175336	0.327012412702112	NA	NA	p.Pro68Phe	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-0.604	-4.7	4.096	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68G	68	P	G	missense	low	0.222069700037189	0.07282701550795	6	0.0297315045807058	0.163797021852818	0.28034237822156	0.313694306473932	0.292593045923978	0.144103235469094	0.174349054349115	NA	NA	0.158399571725869	0.249278986281148	0.519452494417966	0.540096915274715	0.520589674345233	0.461639064458009	0.450877443064115	NA	NA	0.518315314490699	0.527721567557027	NA	NA	p.Pro68Gly	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-0.604	-3.671	3.067	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68H	68	P	H	missense	low	0.15149037417389	0.194670794995376	6	0.0794740192601033	-0.00427584128255548	0.307256589630335	-0.0827608244951493	-0.104455362455612	0.203348998327241	0.257933327474975	NA	NA	0.31902935102368	0.315846755168204	0.478963581785869	0.45565246007564	0.434743135369806	0.479366285566336	0.478560878005402	NA	NA	0.551357675194873	0.542692757120444	NA	NA	p.Pro68His	1	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-0.604	-4.983	4.379	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68I	68	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro68Ile	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-0.604	-4.162	3.558	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68K	68	P	K	missense	low	-0.0314130345970199	0.135144277690952	6	0.0551724203333048	-0.139548991390203	0.0767229221961629	-0.133789624790636	-0.162169740365241	0.0483571874647778	0.0178606014660205	NA	NA	0.178005620484277	-0.136742251841318	0.436947615627622	0.44478338838553	0.4222646075931	0.432990410422025	0.399047861464135	NA	NA	0.522348378209587	0.44090482083322	NA	NA	p.Pro68Lys	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-0.604	-3.76	3.156	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68L	68	P	L	missense	low	-0.0143870430669112	0.116791933543353	6	0.0476801072090431	-0.107838335975644	0.0790642498418218	0.0123075690579812	0.063992831653726	0.0223099980113323	0.12164111264436	NA	NA	-0.115148272283287	-0.19142549748558	0.447732751770379	0.475901910954538	0.471163617496818	0.425196700552894	0.433420368658795	NA	NA	0.462045134881962	0.42860647810414	NA	NA	p.Pro68Leu	1	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-0.604	-2.917	2.313	0.001897306	NA	NA	NA	NA	8.12e-06	NA	NA
P68M	68	P	M	missense	low	0.0765310510957074	0.22972768248186	6	0.0937859336454446	-0.107286001105827	0.260348103297242	-0.0140477952859708	0.24258679962133	-0.217639360984848	-0.139494443117198	NA	NA	0.279722813685206	0.308058292655725	0.490032993056723	0.470288250770198	0.509777735343248	0.353400252393196	0.346931261337177	NA	NA	0.543272121006555	0.540941120395474	NA	NA	p.Pro68Met	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-0.604	-4.904	4.3	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68N	68	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro68Asn	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-0.604	-4.169	3.565	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68Q	68	P	Q	missense	low	-0.340988795303531	0.170385809464859	6	0.06955971543333	-0.477323332327712	-0.204654258279349	-0.25363880373787	-0.271891321124872	-0.260223431577058	-0.187779045587369	NA	NA	-0.651397679956821	-0.421002489837193	0.364355091969806	0.419255660701651	0.398541510458501	0.340658459585359	0.330939214015833	NA	NA	0.351735910569968	0.376974273369643	NA	NA	p.Pro68Gln	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-0.604	-4.202	3.598	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68R	68	P	R	missense	low	-0.108028137788683	0.121535121358405	6	0.0496165055258871	-0.205274701658155	-0.0107815739192119	-0.074605171043443	0.027374383068767	-0.0568162998181504	-0.0349924071633516	NA	NA	-0.296398939075918	-0.212730392700003	0.424287964338876	0.457389604228216	0.463246277929843	0.401520925114487	0.381542740331607	NA	NA	0.424760952981106	0.423814975696646	NA	NA	p.Pro68Arg	1	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-0.604	-4.21	3.606	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68S	68	P	S	missense	low	0.292550592517889	0.411736455877206	6	0.168090704233519	-0.0369011339157821	0.622002318951561	1.03741266460988	0.445640280452808	-0.128018157167342	0.0287981793792852	NA	NA	0.193356377157173	0.178114210675538	0.518611305572396	0.694248035279074	0.553680287748472	0.380216261157761	0.402670429625028	NA	NA	0.525506106753355	0.511716504391438	NA	NA	p.Pro68Ser	1	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-0.604	-3.657	3.053	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68T	68	P	T	missense	low	0.0830955188678196	0.276872419298535	6	0.113032691855221	-0.138444486244027	0.304635523979666	0.545593099990985	0.201067228412125	-0.0415311124713669	0.10517742639543	NA	NA	-0.0435168816889735	-0.268216647431282	0.452373803715983	0.589491073024681	0.50080071538087	0.406094482491534	0.427967532017149	NA	NA	0.476780075414817	0.411336035037609	NA	NA	p.Pro68Thr	1	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-0.604	-2.873	2.269	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68V	68	P	V	missense	low	0.0869681859821963	0.161881147246473	6	0.0660877016217014	-0.0425613290173678	0.21649770098176	0.201835442179248	0.345746873726758	0.0122914649713519	-0.0404421547376253	NA	NA	-0.0834882909007742	0.0858657806542188	0.479763724954572	0.516271114782582	0.532082157513184	0.42219900515979	0.379737762830735	NA	NA	0.468557753708319	0.490969696200825	NA	NA	p.Pro68Val	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-0.604	-3.737	3.133	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68W	68	P	W	missense	low	0.0688990462648975	0.287803160253655	6	0.117495148163652	-0.161387212494058	0.299185305023853	0.129350854039336	0.563040202456343	0.0508933534573376	0.088527702314057	NA	NA	-0.283120432013899	-0.135297402663791	0.437489519442346	0.500831986675342	0.579063532630676	0.433749269336968	0.422453078924963	NA	NA	0.427492409264456	0.441229769547725	NA	NA	p.Pro68Trp	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-0.604	-5.777	5.173	0.001897306	NA	NA	NA	NA	NA	NA	NA
P68X	68	P	X	nonsense	low	-0.0848826457148603	0.133752881759008	6	0.0546043853227301	-0.191905274345359	0.0221399829156382	-0.215976822027173	-0.120466717192668	-0.0423194701078265	-0.24689012365161	NA	NA	0.0265072383151918	0.0898500203749238	0.429279454252717	0.427277616476327	0.431281292029107	0.405858594059015	0.31136139605196	NA	NA	0.491184392231316	0.491865757599938	NA	NA	p.Pro68Ter	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P68Y	68	P	Y	missense	low	0.0657229473406475	0.197910113427228	6	0.0807964654721752	-0.0926352150629499	0.224081109744245	-0.0479880863802231	-0.124552527595645	0.176531197618726	0.411103238771051	NA	NA	0.0318022933138711	-0.0525584316838944	0.467200503883427	0.463059010518606	0.430397891731806	0.471341997248247	0.529291345780634	NA	NA	0.492273611913866	0.459837886351576	NA	NA	p.Pro68Tyr	0	21.6	17.6	14.2	0.482	79.8	3	-65.6	142.8	1.2987012987013	-0.5	0	0	10.89	0	0	0	0	7	7.13703523938788	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-0.604	-4.634	4.03	0.001897306	NA	NA	NA	NA	NA	NA	NA
L69A	69	L	A	missense	possibly_low	0.68864629651512	0.103837138962411	6	0.0423913344680628	0.605560807701125	0.771731785329115	0.547199060498222	0.75623669187654	0.696339770098516	0.597056793750139	NA	NA	0.832500283304019	0.702545179563285	0.623855704138081	0.589833140637158	0.620834887480361	0.626876520795801	0.590879883299087	NA	NA	0.656981251530985	0.629661804037371	NA	NA	p.Leu69Ala	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-0.712	-3.392	2.68	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69C	69	L	C	missense	wt-like	0.974358935660864	0.135803095826368	6	0.0554413817108151	0.865695824254529	1.0830220470672	1.10350124003571	0.985014756079843	1.05950937129848	0.74301453936618	NA	NA	1.06308416837454	0.892029538810424	0.68834532156335	0.708324820546239	0.670299397577516	0.735542314089904	0.639221653871815	NA	NA	0.704413526768966	0.672277116357733	NA	NA	p.Leu69Cys	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-0.712	-4.952	4.24	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69D	69	L	D	missense	possibly_low	0.555754106613374	0.254835954400102	6	0.104036342732569	0.351846621774274	0.759661591452473	0.849161064518836	0.913315673801048	0.444308044334367	0.346263404788785	NA	NA	0.389778950707817	0.391697501529389	0.562831464447243	0.654150676036467	0.654797212122426	0.551464847227992	0.507816141671973	NA	NA	0.565911226862929	0.559751702031557	NA	NA	p.Leu69Asp	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-0.712	-4.397	3.685	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69E	69	L	E	missense	possibly_low	0.642755166926551	0.167288648122738	6	0.0682953046101184	0.508898829577526	0.776611504275575	0.891707940080272	0.761782938079341	0.676461451663194	0.567553739458797	NA	NA	0.436532015104248	0.522492917173453	0.605048206960414	0.663213108192222	0.622034051186266	0.620928629686551	0.581108357466545	NA	NA	0.575528569453858	0.589167784234276	NA	NA	p.Leu69Glu	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-0.712	-4.156	3.444	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69F	69	L	F	missense	possibly_wt-like	0.866551924608456	0.252587325892527	6	0.103118343988463	0.664443684245656	1.06866016497126	1.27086510970102	0.701135240553179	0.726620001045068	0.967695162182273	NA	NA	0.964408967316642	0.568587066852553	0.660026178689967	0.743973118903105	0.608921305184594	0.635936820187776	0.713636746229337	NA	NA	0.684115537192158	0.599534426592099	NA	NA	p.Leu69Phe	1	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-0.712	-2.992	2.28	0.002807043	NA	NA	NA	NA	3.27e-05	NA	NA
L69G	69	L	G	missense	possibly_low	0.621154729801211	0.148760993739762	6	0.0607314213819635	0.502123331162636	0.740186128439785	0.679197245926074	0.862868063537234	0.533547324770869	0.668545287305569	NA	NA	0.440132288790769	0.542638168476748	0.604127815109239	0.617948591756369	0.643889845037379	0.578166578786984	0.614557149205465	NA	NA	0.576269164020468	0.593698481013013	NA	NA	p.Leu69Gly	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-0.712	-4.061	3.349	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69H	69	L	H	missense	possibly_wt-like	0.829018444906512	0.153973346538272	6	0.0628593555012497	0.705816372032663	0.952220517780361	0.804876163128932	1.12766399910386	0.722150371165455	0.744474364402882	NA	NA	0.729393686803375	0.84555208483457	0.642211600047224	0.644718046517272	0.701141842837664	0.634599439870166	0.639705153577177	NA	NA	0.635771701424853	0.661824268297314	NA	NA	p.Leu69His	1	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-0.712	-5.142	4.43	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69I	69	L	I	missense	possibly_wt-like	0.764937609070578	0.223147134886111	6	0.0910994363391638	0.586385994833917	0.943489223307238	0.495353038992754	1.15310000871358	0.717651959532337	0.832683103859048	NA	NA	0.627831021688072	0.763006521637671	0.638256548404838	0.578790001834623	0.706641407485844	0.633253447620096	0.668920229675412	NA	NA	0.614879745839237	0.64325964918958	NA	NA	p.Leu69Ile	1	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-0.712	-3.24	2.528	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69K	69	L	K	missense	wt-like	0.930422322546285	0.154600491849894	6	0.0631153865025916	0.80671843813088	1.05412620696169	1.09019335012136	1.11167729807519	0.833824579648187	0.776894835807091	NA	NA	0.775215103294677	0.994728768331205	0.68169418164272	0.705490256365118	0.697685329918882	0.668014038490675	0.650442939255265	NA	NA	0.645197399314126	0.695374324794765	NA	NA	p.Leu69Lys	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-0.712	-3.958	3.246	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69L	69	L	L	synonymous	wt-like	0.942309253177137	0.196891063401875	6	0.0803804400414277	0.784766485634458	1.09985202071982	1.10303058831074	0.69472355860741	1.03089247159066	0.749424641851697	NA	NA	1.18516194670835	0.890622311993959	0.690092600637801	0.708224572307791	0.607535024085265	0.726979708359433	0.641344704638286	NA	NA	0.729525545245884	0.671960628967811	NA	NA	p.Leu69=	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69M	69	L	M	missense	wt-like	1.0120304830619	0.139939021828887	6	0.0571298664308284	0.900058002415896	1.12400296370791	0.977211970295688	1.05310445725953	1.24210660597475	1.05178153103855	NA	NA	0.908552665567089	0.83942566823581	0.683223276901953	0.681425361445742	0.685021192358165	0.790178146202079	0.741486477220914	NA	NA	0.672625612484062	0.660446428153683	NA	NA	p.Leu69Met	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-0.712	-2.355	1.643	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69N	69	L	N	missense	wt-like	0.891857024076159	0.136629255118912	6	0.0557786598296469	0.782532859704141	1.00118118844818	0.714031703064344	1.08463854180763	0.889788224823986	0.764093157720287	NA	NA	0.977799831585561	0.920790685455147	0.681752370737019	0.625368288275383	0.69183923257966	0.684759200746999	0.646202973898126	NA	NA	0.686870105923115	0.67874554072704	NA	NA	p.Leu69Asn	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-0.712	-4.389	3.677	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69P	69	L	P	missense	possibly_low	0.597055332469402	0.191312990921545	6	0.0781032014872493	0.443975870477118	0.750134794461686	0.764002238391807	0.889142709242016	0.397649114056445	0.51737591623148	NA	NA	0.445784229863397	0.568377787031266	0.58845957811527	0.636011950829123	0.649570732679686	0.537503795267278	0.564489268098893	NA	NA	0.577431796979418	0.599487359251122	NA	NA	p.Leu69Pro	1	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-0.712	-4.381	3.669	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69Q	69	L	Q	missense	possibly_low	0.60553642305215	0.275834606202337	6	0.112609006432877	0.384826826108872	0.826246019995428	0.849402186884272	1.02959013863573	0.411962566942729	0.313285162276051	NA	NA	0.543392267557762	0.485586216016357	0.589188839129402	0.65420203480369	0.679937119918591	0.54178659511486	0.49689362004276	NA	NA	0.597510265637114	0.58086741262169	NA	NA	p.Leu69Gln	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-0.712	-4.355	3.643	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69R	69	L	R	missense	possibly_wt-like	0.761810659178509	0.0973215854614483	6	0.039731370889869	0.683938603177963	0.839682715179055	0.817793124842323	0.926547849915318	0.676785546895053	0.749917302870183	NA	NA	0.66788673147307	0.731933399075108	0.638889566948157	0.647469343472488	0.657658164335178	0.621025603842308	0.64150787587545	NA	NA	0.623119408601419	0.636271258020864	NA	NA	p.Leu69Arg	1	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-0.712	-4.21	3.498	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69S	69	L	S	missense	wt-like	1.03814415323548	0.144864427526602	6	0.0591406548867614	0.922230599635311	1.15405770683564	0.82176778256791	1.02085231896157	0.955744487678924	1.04175021976792	NA	NA	1.1612701278747	1.22747998256184	0.714552590503193	0.648315940678632	0.678047900464774	0.704494304131656	0.738164068081601	NA	NA	0.72461087687473	0.747720416719139	NA	NA	p.Leu69Ser	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-0.712	-3.877	3.165	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69T	69	L	T	missense	possibly_low	0.715847005819981	0.305252225569763	6	0.124618699249145	0.471598843491427	0.960095168148534	0.89068968023929	0.970161913836653	0.863576895935269	0.880235666314695	NA	NA	0.191821084506726	0.49859679408725	0.665042129185935	0.662996220098701	0.667088038273169	0.676916377896259	0.684669822509104	NA	NA	0.525190289264441	0.583793510850391	NA	NA	p.Leu69Thr	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-0.712	-3.736	3.024	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69V	69	L	V	missense	possibly_low	0.673444799311984	0.109143269935706	6	0.0445575533668877	0.586113599473662	0.760775999150305	0.54495967402058	0.832272722556694	0.555668999476404	0.697010485560976	NA	NA	0.679296541559411	0.731460372697838	0.624725698767054	0.589356154072191	0.637274772223786	0.584785715749242	0.623984933099785	NA	NA	0.625466464434323	0.636164873689813	rs200591577	*21	p.Leu69Val	1	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-0.712	-3.177	2.465	0.002807043	0.833865815	0.0299999998689032	1.05	NA	3.61e-05	NA	NA
L69W	69	L	W	missense	low	0.424646056067934	0.20448555030806	6	0.0834808763378278	0.261026545047949	0.588265567087918	0.517772751673879	0.76409699409979	0.341149094912982	0.374323980464239	NA	NA	0.15068791263655	0.399845602620163	0.541091181938359	0.583565373056203	0.622534377333301	0.520598141872637	0.517109913000902	NA	NA	0.516728987083846	0.561584222004081	NA	NA	p.Leu69Trp	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-0.712	-5.314	4.602	0.002807043	NA	NA	NA	NA	NA	NA	NA
L69X	69	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu69Ter	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L69Y	69	L	Y	missense	possibly_low	0.676376036825365	0.232945306393813	6	0.0950995231068548	0.489984396588995	0.862767677061735	0.673249696189909	1.11455981213471	0.605591253484905	0.419980579591776	NA	NA	0.585458233737367	0.659416645813522	0.611422609659731	0.616681770978915	0.698308563384462	0.599723203129625	0.532231555438163	NA	NA	0.606163448340547	0.619962133083167	NA	NA	p.Leu69Tyr	0	20.2	13.9	14.2	0.932	86.7	176.2	51.4	54	21.9895287958115	-0.8	0	0	10.34	0	0	0	0	8	3.26773193641468	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-0.712	-4.165	3.453	0.002807043	NA	NA	NA	NA	NA	NA	NA
C70A	70	C	A	missense	possibly_low	0.518502543451514	0.39802214677953	6	0.1624918609895	0.200024348131206	0.836980738771823	0.956410988485415	0.986376486724267	0.217788082602377	0.592625534644373	NA	NA	0.0132798568453175	0.344534311407337	0.569278432010962	0.676994777908379	0.670593819769807	0.483686676210305	0.589412233123105	NA	NA	0.488463452741703	0.549144630898818	NA	NA	p.Cys70Ala	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-0.872	-2.18	1.308	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70C	70	C	C	synonymous	wt-like	1.0520212354952	0.236996464115614	6	0.0967534013211797	0.862388053523935	1.24165441746646	0.781987005455298	0.770967812180089	0.991278804450426	1.27303203105807	NA	NA	1.25073503775485	1.24412672207245	0.729070483824324	0.639842684089774	0.624019929068744	0.715126704829239	0.814765499624983	NA	NA	0.74301426281941	0.751464293027344	NA	NA	p.Cys70=	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	0	2.5	2.5	0	148	148	0	5.5	5.5	0	121	121	0	5.07	5.07	0	NA	NA	NA	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70D	70	C	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys70Asp	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-0.872	-4.116	3.244	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70E	70	C	E	missense	low	0.153667260159714	0.225010329782806	6	0.0918600824705407	-0.0263751930994251	0.333709713418853	-0.144766416015158	-0.0012531416765508	0.456854616923804	0.277769946984342	NA	NA	0.0393777641836295	0.294020790558217	0.489481383958773	0.442445345357753	0.457056670146629	0.555218969982343	0.485130843204666	NA	NA	0.49383192471288	0.53778406543611	NA	NA	p.Cys70Glu	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-0.872	-4.175	3.303	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70F	70	C	F	missense	low	0.401905073762938	0.27981770510338	6	0.114235099749976	0.178008392482644	0.625801755043232	0.621626832754703	0.848093013861222	0.355088566221875	0.292761270463485	NA	NA	0.147113024070232	0.146747735206111	0.520381327593357	0.605686164570829	0.64069530540164	0.524769040821438	0.490096027595199	NA	NA	0.515993614365276	0.504662137720597	NA	NA	p.Cys70Phe	1	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-0.872	-4.335	3.463	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70G	70	C	G	missense	possibly_low	0.68174911835596	0.213170132068844	6	0.0870263419950614	0.511180622339374	0.852317614372546	0.842458234526147	1.04300593521064	0.557522473119437	0.587218388539342	NA	NA	0.546539735024516	0.513749943715684	0.592889540530207	0.652722981493478	0.682837773036065	0.585340302870808	0.587621365393823	NA	NA	0.598157715666591	0.587201476587609	NA	NA	p.Cys70Gly	1	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-0.872	-3.715	2.843	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70H	70	C	H	missense	low	0.406076411814423	0.187010034315068	6	0.0763465268087149	0.25643996892462	0.555712854704226	0.483644299878773	0.674236337930174	0.195121561723833	0.227991887543022	NA	NA	0.328275544930324	0.527188838880411	0.564777859503657	0.576296054806793	0.603105445849341	0.476904513098784	0.468644157151031	NA	NA	0.553259664200521	0.590223903963466	NA	NA	p.Cys70His	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-0.872	-5.087	4.215	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70I	70	C	I	missense	low	0.251821419972843	0.271772279165285	6	0.110950568364696	0.0343623019137911	0.469280538031896	0.637651243845481	0.371216957738699	0.139330038296097	0.399947418289272	NA	NA	-0.131126413984664	0.0939092756521748	0.50918759247222	0.609099344420814	0.537589089448164	0.460210852251814	0.5255964948359	NA	NA	0.458758350054222	0.492778690108539	NA	NA	p.Cys70Ile	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-0.872	-3.914	3.042	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70K	70	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys70Lys	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-0.872	-4.064	3.192	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70L	70	C	L	missense	possibly_low	0.630152735952399	0.152232900592463	6	0.0621488214192283	0.5083432842891	0.751962187615698	0.665829439236013	0.866800937819376	0.734941429755344	0.516354115856378	NA	NA	0.499164641721408	0.497825851325877	0.601756841974426	0.615101265375728	0.644740178745365	0.638426716503863	0.564150843857714	NA	NA	0.588412418573124	0.583620124684443	NA	NA	p.Cys70Leu	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-0.872	-3.487	2.615	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70M	70	C	M	missense	possibly_wt-like	0.839069694567158	0.1091582843589	2	0.0771865630928676	0.687786810814709	0.990352578319608	0.761883131474291	0.916256257660026	NA	NA	NA	NA	NA	NA	0.645496792312303	0.635560583662501	0.655433000962105	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys70Met	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-0.872	-4.813	3.941	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70N	70	C	N	missense	low	0.478152148672504	0.265510912021657	6	0.108394375932343	0.265703075718418	0.690601221626591	0.622065400801114	0.896472611740621	0.484656057505603	0.468205635015639	NA	NA	0.214759742756497	0.182753444215552	0.555870729327595	0.605779579025212	0.651155543869587	0.563537578108018	0.548203880547172	NA	NA	0.529908887666755	0.512759874868138	NA	NA	p.Cys70Asn	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-0.872	-4.26	3.388	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70P	70	C	P	missense	possibly_wt-like	0.825796533367289	0.329641186000481	6	0.134575450651177	0.562033496887736	1.08955956984684	0.950250680557211	1.21725121277445	1.02660578137031	0.862111776898052	NA	NA	0.29208856307147	0.606471185532244	0.677174880023441	0.675682639897745	0.720511652835038	0.725697066332508	0.678667120149137	NA	NA	0.545815818404289	0.608054620849457	NA	NA	p.Cys70Pro	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-0.872	-4.303	3.431	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70Q	70	C	Q	missense	possibly_low	0.598152500102154	0.190302858969496	6	0.0776908168446822	0.445881297157079	0.750423703047229	0.647085832265171	0.707747561326488	0.503576097490627	0.895030993289742	NA	NA	0.465115984842324	0.370358531398573	0.595879701917927	0.611108900148295	0.610350966759868	0.569198737927935	0.689570092098481	NA	NA	0.581408437075985	0.554952536125027	NA	NA	p.Cys70Gln	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-0.872	-4.498	3.626	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70R	70	C	R	missense	possibly_low	0.678981344765244	0.0972390304293194	6	0.0396976679391332	0.601175345334312	0.756787344196175	0.627719132258752	0.833833357273657	0.71697964552987	0.683093075491544	NA	NA	0.540575394414379	0.67168746362326	0.621048645562793	0.606983816870779	0.637612199817572	0.633052281183865	0.619375432989302	NA	NA	0.596930820537529	0.622721858136284	NA	NA	p.Cys70Arg	1	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-0.872	-4.349	3.477	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70S	70	C	S	missense	wt-like	0.906423136592477	0.154976770550853	6	0.0632690016389963	0.782418172042238	1.03042810114272	0.65893884972119	0.850154619761322	0.950405863692572	1.06096563275529	NA	NA	0.848764324658948	1.06930952896554	0.681611877554035	0.613633578285495	0.64114104886143	0.702896907739835	0.744528287275141	NA	NA	0.660326847368235	0.712147648039757	NA	NA	p.Cys70Ser	1	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-0.872	-2.485	1.613	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70T	70	C	T	missense	low	0.458227418181371	0.26626305680282	6	0.108701437753434	0.245176515116918	0.671278321245824	0.738055935831551	0.853324955356051	0.22300263360944	0.297988329780058	NA	NA	0.321428361266851	0.315564293244276	0.547240197395972	0.630485420301506	0.641826512730455	0.485246948105262	0.491827249882755	NA	NA	0.551851163775473	0.542629231016471	NA	NA	p.Cys70Thr	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-0.872	-3.118	2.246	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70V	70	C	V	missense	possibly_low	0.665705995007112	0.186863818081446	6	0.0762868342813007	0.516186547321188	0.815225442693037	0.648604569794458	1.01224829137158	0.465021015157111	0.603702321807252	NA	NA	0.695017862026423	0.569641909885847	0.605602025861187	0.611432389373765	0.676187608434229	0.557662478853806	0.593080907926561	NA	NA	0.628700419830936	0.599771662348609	NA	NA	p.Cys70Val	0	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-0.872	-3.618	2.746	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70W	70	C	W	missense	low	0.486002284340442	0.160693048728373	6	0.0656026624327844	0.357423428682246	0.614581139998638	0.613783724405832	0.669660213656488	0.525481811490745	0.498043653371616	NA	NA	0.228761860834404	0.380282442283566	0.566919801991081	0.604015592140681	0.602116033922416	0.575753256207085	0.558086347775078	NA	NA	0.532789194407978	0.557184438343678	NA	NA	p.Cys70Trp	1	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-0.872	-5.429	4.557	0.003138013	NA	NA	NA	NA	NA	NA	NA
C70X	70	C	X	nonsense	low	-0.0173123311775308	0.183402686529221	6	0.0748738332420341	-0.164062347716376	0.129437685361314	0.066223097967011	-0.0397599478003217	0.0246937940257343	0.256955554122035	NA	NA	-0.126897403618588	-0.285089081761056	0.45417966220046	0.487385852288237	0.448731045454631	0.425909968084373	0.478237035684459	NA	NA	0.45962827894629	0.407541399631157	NA	NA	p.Cys70Ter	1	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C70Y	70	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys70Tyr	1	19.3	14.5	17.8	0.603	9.2	-178.5	-77.8	-15.9	5.40540540540541	-5.2	0	0	11.16	0	0	0	0	10	5.47840381606731	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-0.872	-3.497	2.625	0.003138013	NA	NA	NA	NA	NA	NA	NA
G71A	71	G	A	missense	possibly_low	0.673045705870262	0.185418559108618	6	0.075696809776366	0.524682684964005	0.821408726776519	0.82572818125473	0.801868413964357	0.440697247382623	0.582965140719468	NA	NA	0.507691470606843	0.879323781293551	0.610433716702219	0.649159500727059	0.630701002860888	0.550384442607427	0.586212673245081	NA	NA	0.59016643054355	0.669419572721943	NA	NA	p.Gly71Ala	1	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.474	-3.132	2.658	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71C	71	G	C	missense	low	0.517192584747707	0.202416583341765	6	0.0826362241108115	0.355228561672137	0.679156607823278	0.643105017845926	0.830279640870459	0.320808141342855	0.336708269680493	NA	NA	0.580766981339439	0.391487457407072	0.582451448357534	0.610260991573975	0.636843844505534	0.514511823390163	0.504651443921629	NA	NA	0.605198433916919	0.559704462798149	NA	NA	p.Gly71Cys	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.474	-5.358	4.884	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71D	71	G	D	missense	low	0.51849576987514	0.233581409679003	6	0.0953592111855921	0.33159515035723	0.705396389393049	0.723602740209824	0.84071873342494	0.464525534638286	0.518313590837854	NA	NA	0.204306864430801	0.359507155709135	0.561157026604298	0.627406907413606	0.639100899179304	0.557514223648905	0.564799829559691	NA	NA	0.527758677552888	0.55251204570171	NA	NA	p.Gly71Asp	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.474	-3.748	3.274	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71E	71	G	E	missense	possibly_low	0.596855046911184	0.279355940886441	6	0.114046585297813	0.373327847167694	0.820382246654673	1.02057409024888	0.87602936958145	0.471583040785122	0.421895561833237	NA	NA	0.343801828191476	0.447246390826936	0.565935332334261	0.690661439654072	0.646735474306877	0.559625935371444	0.532865804972347	NA	NA	0.556453499454188	0.572244729297077	NA	NA	p.Gly71Glu	1	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.474	-3.913	3.439	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71F	71	G	F	missense	low	0.496413246465044	0.181612019076538	6	0.074142796315687	0.351096035973208	0.641730456956879	0.639321194459071	0.777838279262408	0.490856354743496	0.418253293756601	NA	NA	0.30220577188432	0.350004584684367	0.557883851752204	0.609455041847227	0.625505404914294	0.56539280006434	0.531659471680599	NA	NA	0.547896979596037	0.550374903440069	NA	NA	p.Gly71Phe	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.474	-4.563	4.089	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71G	71	G	G	synonymous	wt-like	1.09410788943921	0.125450755191129	6	0.0512150563441789	0.993728223538432	1.19448755533999	1.00733226046046	0.923515803727079	1.1616418827092	1.12374167488778	NA	NA	1.28326467557096	1.06515103927979	0.730459085976622	0.687840946198511	0.657002600263441	0.76610189379287	0.765319955531077	NA	NA	0.749705774387158	0.711212397566086	NA	NA	p.Gly71=	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71H	71	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly71His	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.474	-4.928	4.454	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71I	71	G	I	missense	low	0.546522079729434	0.113211428577316	6	0.0462183721776609	0.455935734837151	0.637108424621718	0.533866237022928	0.62371822619495	0.721582984754197	0.520447828601077	NA	NA	0.483585844461321	0.395931357342133	0.586100523280813	0.586993265638228	0.592182835516404	0.634429669343448	0.565506697371755	NA	NA	0.585207780923397	0.560703902458528	NA	NA	p.Gly71Ile	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.474	-4.496	4.022	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71K	71	G	K	missense	possibly_low	0.531547067503711	0.448453994150843	6	0.183080576463773	0.172715731365885	0.890378403641537	0.935088934242493	1.06955048640161	0.655869796715988	0.481240992463651	NA	NA	-0.0752069755404374	0.122739170738956	0.583644269502234	0.672453206583858	0.688577017421155	0.614767297590795	0.552521241413673	NA	NA	0.470261262300794	0.499262576104027	NA	NA	p.Gly71Lys	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.474	-3.895	3.421	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71L	71	G	L	missense	possibly_low	0.563270117125137	0.240427061678355	6	0.0981539369114383	0.370891935837901	0.755648298412372	0.907003349266698	0.78856269176606	0.371755218399248	0.501927154154397	NA	NA	0.283336687095328	0.527035602069088	0.574781009525752	0.666471011533358	0.627824149119165	0.529755953201844	0.55937257827328	NA	NA	0.544015513105321	0.590189440778223	NA	NA	p.Gly71Leu	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.474	-4.056	3.582	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71M	71	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly71Met	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.474	-5.178	4.704	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71N	71	G	N	missense	possibly_low	0.585485256883205	0.328864072796676	6	0.134258195514226	0.322344029045984	0.848626484720425	0.244801502605367	1.14273162116658	0.371017320023699	0.494738203631934	NA	NA	0.797155127848016	0.462467766023635	0.566329804543127	0.525422832798856	0.704399640066856	0.529535162937228	0.556991570020866	NA	NA	0.649710573697599	0.575668039065388	NA	NA	p.Gly71Asn	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.474	-3.719	3.245	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71P	71	G	P	missense	possibly_low	0.682115816263091	0.175087965339894	6	0.0714793625308079	0.542018840064825	0.822212792461356	0.716625968526266	1.00094078069744	0.512657118928384	0.691646673072605	NA	NA	0.547147345063302	0.623677011290545	0.617066327056428	0.62592086362745	0.673742791542091	0.571915915784215	0.622208417632151	NA	NA	0.598282704134836	0.611924236480705	NA	NA	p.Gly71Pro	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.474	-4.15	3.676	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71Q	71	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly71Gln	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.474	-4.357	3.883	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71R	71	G	R	missense	possibly_low	0.711145564322748	0.130491755359229	6	0.0532730360450338	0.606732332327378	0.815558796318118	0.804342281780772	0.920187502382512	0.699296859329947	0.640583871858666	NA	NA	0.559549572950964	0.642913297633627	0.62200591597799	0.644604330446866	0.656282982340114	0.627761326258905	0.605296220128233	NA	NA	0.600833905345414	0.616250505697074	ND	*18	p.Gly71Arg	1	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.474	-3.293	2.819	0.000946659	NA	NA	0.85	NA	1.22e-05	NA	NA
G71S	71	G	S	missense	possibly_low	0.69004661044337	0.135651558366258	6	0.0553795168017839	0.581504752030643	0.798588468856097	0.540431282354304	0.889031366950533	0.825166235517139	0.645363025082848	NA	NA	0.620547840546097	0.619739912209298	0.612210167800738	0.588391612217853	0.649546659165818	0.665423332025968	0.606879094183462	NA	NA	0.613381558520429	0.611038777081047	NA	NA	p.Gly71Ser	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.474	-3.44	2.966	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71T	71	G	T	missense	low	0.330555916852165	0.200338905679007	6	0.0817880157568559	0.170254351601733	0.490857482102597	0.420386557573899	0.618372531189112	0.210309513766081	0.355131254994333	NA	NA	0.0238089494128061	0.355326694176761	0.531162530864138	0.562822233512057	0.591027033339682	0.481448976213897	0.510753208001003	NA	NA	0.49062934051185	0.551571853727273	NA	NA	p.Gly71Thr	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.474	-3.907	3.433	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71V	71	G	V	missense	possibly_low	0.594201344138101	0.170796945934326	6	0.0697275611941374	0.457537835467779	0.730864852808423	0.708169208403299	0.855100777779574	0.628990183952195	0.494703208889918	NA	NA	0.386246736047205	0.491997949756414	0.594516967595151	0.6241195841243	0.642210466439063	0.606724514178403	0.556979979626792	NA	NA	0.565184632383308	0.582309421011898	NA	NA	p.Gly71Val	1	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.474	-4.024	3.55	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71W	71	G	W	missense	low	0.571703973152889	0.184819758628547	6	0.075452350504048	0.423820083616062	0.719587862689715	0.738554043583411	0.833720616365185	0.545011598452869	0.529652970524326	NA	NA	0.45069681458826	0.33258779540328	0.580019601028192	0.630591516639907	0.63758782390625	0.581596861470554	0.568555476023856	NA	NA	0.57844234058583	0.54645784180089	NA	NA	p.Gly71Trp	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.474	-5.376	4.902	0.000946659	NA	NA	NA	NA	NA	NA	NA
G71X	71	G	X	nonsense	possibly_low	0.573144487535068	0.755652079551615	6	0.30849366966241	-0.0314919944618517	1.17778096953199	-0.347220883254938	-0.444418051310379	0.913557732077545	1.14638452152654	NA	NA	1.12705390413929	1.04350970203235	0.699108311389156	0.399322792884052	0.361239200829259	0.691871393929973	0.772819354022773	NA	NA	0.717572426024942	0.706345228848339	NA	NA	p.Gly71Ter	1	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G71Y	71	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly71Tyr	0	17.5	11.2	18.7	0.315	74.1	-42.5	51.1	-130.1	6.18556701030928	-0.8	0	0	12.48	0	0	0	0	8	5.38202895241452	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.474	-4.648	4.174	0.000946659	NA	NA	NA	NA	NA	NA	NA
K72A	72	K	A	missense	wt-like	0.838571153701095	0.0557249970022997	6	0.0227496347622928	0.793982688905561	0.883159618496629	0.839536494025559	0.934202645379193	0.763087137463649	0.841477409190905	NA	NA	0.840441845948739	0.812681390198524	0.656523235889763	0.652100654361017	0.659313221208017	0.64684833451881	0.671832937657471	NA	NA	0.658614871265811	0.654431600513714	NA	NA	p.Lys72Ala	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-0.84	-2.645	1.805	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72C	72	K	C	missense	low	0.49755302253533	0.278391592573672	6	0.113652891747714	0.274797447970981	0.720308597099679	0.890508798529323	0.815220465881032	0.375427026438115	0.333923686717024	NA	NA	0.274236333662362	0.296001823984123	0.540186563502673	0.662957692516988	0.633587873633006	0.530854613255022	0.503729179260766	NA	NA	0.542143524225164	0.538229602780182	NA	NA	p.Lys72Cys	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-0.84	-3.422	2.582	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72D	72	K	D	missense	possibly_low	0.697835630444605	0.19089207653271	6	0.0779313639075757	0.545092963919672	0.850578296969538	0.932867624024642	0.852971575949149	0.605883184848774	0.52055702516872	NA	NA	0.804244241705488	0.470490130970858	0.620780330658545	0.671980070239989	0.641750107943563	0.599810553373526	0.565542863697824	NA	NA	0.651168840391206	0.577472280793476	NA	NA	p.Lys72Asp	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-0.84	-3.217	2.377	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72E	72	K	E	missense	possibly_low	0.678510562804791	0.11571503769886	6	0.0472404663215212	0.585920950201732	0.77110017540785	0.611664663053263	0.85684494798114	0.60990648098717	0.548883725092199	NA	NA	0.77387485854954	0.669888701165436	0.61294077424077	0.603564234679336	0.642587576564752	0.601014383939442	0.574924776408271	NA	NA	0.644921704169089	0.622317313802204	NA	NA	p.Lys72Glu	1	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-0.84	-3.44	2.6	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72F	72	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys72Phe	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-0.84	-4.524	3.684	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72G	72	K	G	missense	possibly_wt-like	0.769225625448852	0.141914080166352	6	0.0579361806206647	0.655672798030542	0.882778452867162	0.885874882363206	0.954590146944123	0.618138429291322	0.726720848950698	NA	NA	0.609612315269933	0.820417129873832	0.644998250151619	0.661970674073995	0.663721238998211	0.603477506375546	0.63382512050852	NA	NA	0.611132065479698	0.656171379794717	NA	NA	p.Lys72Gly	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-0.84	-3.666	2.826	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72H	72	K	H	missense	possibly_wt-like	0.727896188577405	0.222015246902151	6	0.0906373450047158	0.55025025671383	0.905542120440979	0.597326082352623	1.07499576580139	0.702335470689051	0.495360545026063	NA	NA	0.911984718111093	0.585374549484203	0.615990240300912	0.600510134628635	0.689754350915913	0.628670524365681	0.557197691900633	NA	NA	0.673331603108033	0.603309956236144	NA	NA	p.Lys72His	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-0.84	-4.834	3.994	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72I	72	K	I	missense	possibly_low	0.642199769980293	0.159147816948985	2	0.112534500575663	0.421636201833792	0.862763338126794	0.754734270555956	0.52966526940463	NA	NA	NA	NA	NA	NA	0.60294268218888	0.634037885081032	0.571847479296728	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys72Ile	1	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-0.84	-3.416	2.576	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72K	72	K	K	synonymous	wt-like	1.08051892901428	0.0572053258983389	6	0.023353976503425	1.03474597617177	1.12629188185678	1.10220539239324	1.06662994109986	1.13695084921044	0.973309334750186	NA	NA	1.10897079609477	1.09504726053717	0.71467441043189	0.708048806592473	0.687945561153392	0.758713966131719	0.715496181924841	NA	NA	0.713852638938939	0.717936101892626	NA	NA	p.Lys72=	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72L	72	K	L	missense	low	0.372978817691912	0.292210544245134	6	0.119294455143591	0.139165982055145	0.60679165332868	0.478134895596619	0.918351548788905	0.148741173300122	0.298745648710795	NA	NA	0.21539288921611	0.178506750538924	0.520921958146481	0.575122558472061	0.655886027564817	0.463026805039798	0.49207807684535	NA	NA	0.530039129106347	0.511804787186614	NA	NA	p.Lys72Leu	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-0.84	-3.573	2.733	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72M	72	K	M	missense	low	0.416031692559893	0.360735556030624	6	0.147269674059033	0.127388435389235	0.704674949730551	0.529867977637248	1.09014595967986	0.269785081571861	0.112578366856968	NA	NA	0.167586682217006	0.326226087396409	0.532616117004971	0.586141641307517	0.693030001143504	0.499244958410308	0.430418752158321	NA	NA	0.520205149737963	0.545027084271979	NA	NA	p.Lys72Met	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-0.84	-3.381	2.541	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72N	72	K	N	missense	low	0.436060722876937	0.201040954700333	6	0.0820746260696339	0.275197411735863	0.596924034018012	0.453805422401028	0.777429212933897	0.175584594976652	0.309909828001952	NA	NA	0.426369398847804	0.473265880100291	0.571689239165364	0.569940410610183	0.62541695995954	0.471058759535908	0.49577569626012	NA	NA	0.573438067720546	0.578096550873306	NA	NA	p.Lys72Asn	1	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-0.84	-3.852	3.012	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72P	72	K	P	missense	low	0.533865920655192	0.191681370067153	6	0.0782535916436864	0.380491699372662	0.687240141937722	0.659262316838445	0.86528055709684	0.39282793012336	0.45058734060892	NA	NA	0.463959528109387	0.371277851154201	0.568164920276928	0.613702476383559	0.644411454538946	0.536061224702521	0.542368633212421	NA	NA	0.581170548057675	0.555159292496181	NA	NA	p.Lys72Pro	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-0.84	-4.043	3.203	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72Q	72	K	Q	missense	wt-like	0.919176790178591	0.174971836329572	6	0.0714319530608707	0.779172734833928	1.05918084552325	1.10026726215075	1.10157352751342	0.854392486159763	0.702671505692821	NA	NA	0.750477783807781	1.00567817574701	0.68483452025236	0.707635987235005	0.695500775806526	0.674168264698194	0.625859884889882	NA	NA	0.640108807168176	0.697836862698163	NA	NA	p.Lys72Gln	1	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-0.84	-3.885	3.045	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72R	72	K	R	missense	possibly_wt-like	0.73565180242419	0.119586637444066	6	0.0488210402988616	0.639964321750642	0.831339283097737	0.624222400044346	0.918101029471887	0.732735139968136	0.804173834269948	NA	NA	0.744032065288215	0.590646345502607	0.638274725829554	0.606239017210598	0.655831862339976	0.637766561498676	0.659477849184706	NA	NA	0.638782890160433	0.604495590948719	NA	NA	p.Lys72Arg	1	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-0.84	-2.886	2.046	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72S	72	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys72Ser	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-0.84	-3.049	2.209	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72T	72	K	T	missense	possibly_wt-like	0.777215659340661	0.125342767244374	6	0.0511709704495254	0.676922400205628	0.877508918475694	0.619034610531444	0.979446435064879	0.733182552852471	0.695089521752595	NA	NA	0.801227643739516	0.835313192103062	0.644224372514155	0.605134024426084	0.669095461037411	0.637900434146182	0.623348702447473	NA	NA	0.650548310882128	0.659521526196058	NA	NA	p.Lys72Thr	1	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-0.84	-3.727	2.887	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72V	72	K	V	missense	low	0.448548346611802	0.250270828721363	6	0.102172637978471	0.24829365596855	0.648803037255054	0.629190176192991	0.757093224055358	0.530213365678001	0.47380332672794	NA	NA	0.136940757989181	0.16404922902734	0.563613432963327	0.607297147419174	0.621020079818426	0.577169008207179	0.550057857719475	NA	NA	0.513901127614076	0.508553269240529	NA	NA	p.Lys72Val	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-0.84	-3.733	2.893	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72W	72	K	W	missense	low	0.349035994034333	0.218660143337667	6	0.0892676297101859	0.174074654817111	0.523997333251555	0.659815806825647	0.588716654456796	0.232139395331783	0.275291889707974	NA	NA	0.144710548493441	0.193541669390354	0.515342787797693	0.61382036906996	0.584615083753632	0.487980804290959	0.484310101038399	NA	NA	0.515499412947965	0.51518616264742	NA	NA	p.Lys72Trp	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-0.84	-5.629	4.789	0.002057103	NA	NA	NA	NA	NA	NA	NA
K72X	72	K	X	nonsense	low	0.212898830550879	0.375770505359566	6	0.153407666419785	-0.0877746705842338	0.513572331685991	-0.19699892856048	-0.147163311306403	0.266279056136044	0.524031507979326	NA	NA	0.752155997268236	0.0790886617885504	0.493820707577637	0.431319884439169	0.425509174174639	0.49819590299919	0.566693625859711	NA	NA	0.640454024192948	0.489445512156083	NA	NA	p.Lys72Ter	1	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K72Y	72	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys72Tyr	0	16.4	11.8	22.4	0.165	80.4	-179.8	-117.8	38.4	8.26086956521739	-0.5	0	0	13.16	2	30	2	30	5	9.24128283150672	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-0.84	-4.488	3.648	0.002057103	NA	NA	NA	NA	NA	NA	NA
A73A	73	A	A	synonymous	wt-like	1.08402703954255	0.108481767369877	6	0.0442874960752506	0.997225142269602	1.1708289368155	1.02199554755177	1.02019457873188	0.938333335794993	1.22536399743788	NA	NA	1.12426296376049	1.1740118139783	0.708141470847991	0.690964208310989	0.677905689285804	0.699284626269357	0.798977662294431	NA	NA	0.716998315426625	0.735695346616052	NA	NA	p.Ala73=	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73C	73	A	C	missense	wt-like	1.0126418076452	0.132235521837701	6	0.0539849257288383	0.906833297508609	1.1184503177818	0.913579761976756	0.975881609067524	0.889044588165898	1.01169787114282	NA	NA	1.026430098756	1.25921691676221	0.690705146076263	0.667871779350659	0.668324703700361	0.684536693502156	0.728210613838563	NA	NA	0.696873598650369	0.75485810010585	NA	NA	p.Ala73Cys	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.712	-5.013	3.301	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73D	73	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala73Asp	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.712	-3.833	2.121	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73E	73	A	E	missense	low	0.480954699543417	0.208215641679552	6	0.0850036797635134	0.314350548653555	0.647558850433279	0.628873800054909	0.785758386652513	0.476651445469132	0.449784799933035	NA	NA	0.188829253591207	0.355830511559707	0.556413820547453	0.607229759690951	0.627217825348187	0.561142478093918	0.54210282863271	NA	NA	0.524574854463319	0.551685163000988	NA	NA	p.Ala73Glu	1	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.712	-3.279	1.567	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73F	73	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala73Phe	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.712	-4.48	2.768	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73G	73	A	G	missense	possibly_wt-like	0.804504866590709	0.114620983796341	6	0.0467938206861422	0.712790663346845	0.896219069834573	0.729821471164422	1.02541249368203	0.736069629798323	0.77056378509149	NA	NA	0.830095970521232	0.735065849286757	0.643555180812085	0.628731489456994	0.679033863910573	0.63876429088305	0.64834607074112	NA	NA	0.656486672191078	0.63697575070104	NA	NA	p.Ala73Gly	1	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.712	-3.487	1.775	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73H	73	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala73His	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.712	-5.004	3.292	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73I	73	A	I	missense	low	0.356481837720722	0.138702967621109	6	0.0566252494135825	0.245498388254503	0.467465287186941	0.577333897373169	0.307426506429977	0.460777806226117	0.206781006815377	NA	NA	0.336500882715451	0.25007092676424	0.541425667031666	0.5962518238213	0.523796843089884	0.556392847081005	0.461619031314416	NA	NA	0.554951657921722	0.52789967614161	NA	NA	p.Ala73Ile	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.712	-3.998	2.286	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73K	73	A	K	missense	possibly_low	0.646116733291876	0.323933817577219	3	0.187023276777831	0.279557846536661	1.01267562004709	0.844582255194907	0.82145945491659	0.272308489764131	NA	NA	NA	NA	NA	0.634936816492628	0.65317539528307	0.634936816492628	0.5	NA	NA	NA	NA	NA	NA	NA	p.Ala73Lys	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.712	-3.78	2.068	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73L	73	A	L	missense	wt-like	1.07621526517395	0.165980251066606	5	0.0742286248614828	0.930729833823513	1.22170069652439	1.23905408677504	0.987081373675845	1.14174241418101	NA	NA	NA	0.830886606039604	1.18231184519827	0.737197410152045	0.737197410152045	0.670746224624945	0.76014767425852	NA	NA	NA	0.656649309929222	0.73756203589908	NA	NA	p.Ala73Leu	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.712	-3.615	1.903	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73M	73	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala73Met	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.712	-4.878	3.166	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73N	73	A	N	missense	possibly_wt-like	0.745016544126289	0.260041132467054	4	0.130020566233527	0.490180917059071	0.999852171193506	0.784550073194029	1.01841400114577	0.785518308859471	0.391583793305888	NA	NA	NA	NA	0.646974345949672	0.640388614365178	0.677520707455078	0.653560077534165	0.522826429853075	NA	NA	NA	NA	NA	NA	p.Ala73Asn	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.712	-3.876	2.164	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73P	73	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala73Pro	1	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.712	-4.085	2.373	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73Q	73	A	Q	missense	wt-like	0.958171165969734	0.236816386133848	6	0.0966798847929736	0.768682073746024	1.14766025819344	0.627696347786719	0.814024958956327	1.11887912418153	0.816265871906419	NA	NA	1.20294628566137	1.16921440732604	0.698333326445141	0.606978963806264	0.633329390965298	0.753306634873899	0.663482778876597	NA	NA	0.733183874013686	0.734616402772741	NA	NA	p.Ala73Gln	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.712	-4.214	2.502	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73R	73	A	R	missense	possibly_low	0.706412119635674	0.0997195642201209	6	0.0407103416186658	0.626621316264767	0.786202923006581	0.644917123822018	0.609545864252353	0.792634774788481	0.840263146729888	NA	NA	0.607362811680713	0.743748996540592	0.624798967261268	0.610646967917729	0.589118604061997	0.655689430908101	0.671430769228124	NA	NA	0.610669331176474	0.638928603346061	NA	NA	p.Ala73Arg	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.712	-4.14	2.428	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73S	73	A	S	missense	low	0.219628053734668	0.521063252931038	6	0.212723182232636	-0.197301722118049	0.636557829587384	0.79225571563866	0.904677257739692	-0.171498146286681	0.186700545546779	NA	NA	-0.368665312813717	-0.0257017374167265	0.460423150673965	0.642029906726826	0.652929484899633	0.367206396085187	0.454968304780213	NA	NA	0.409895393193466	0.465877996567718	NA	NA	p.Ala73Ser	1	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.712	-1.337	-0.375	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73T	73	A	T	missense	possibly_wt-like	0.812311605930174	0.124587100782729	6	0.0508624709083983	0.712622994784998	0.912000217075351	0.886706525711953	1.01307665886471	0.708174829949253	0.748877396491378	NA	NA	0.683977003261616	0.833057221302132	0.650088804942953	0.662147813084236	0.676366711235762	0.630417748263943	0.641163454855729	NA	NA	0.626429259157085	0.659014155030178	NA	NA	p.Ala73Thr	1	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.712	-1.501	-0.211	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73V	73	A	V	missense	low	0.306764424788854	0.278873223010471	6	0.113849516550173	0.0836234726932194	0.529905376884489	0.626403682550217	0.667178939310844	0.306526678663922	0.112444215167679	NA	NA	0.0398297344599482	0.0882032985805157	0.502081746392386	0.606703627701055	0.601579553205388	0.510238595492567	0.430374320599323	NA	NA	0.493924897292205	0.49149540743567	NA	NA	p.Ala73Val	1	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.712	-2.91	1.198	0.006198794	NA	NA	NA	NA	1.08e-05	NA	NA
A73W	73	A	W	missense	low	0.595792768161815	0.0978166612500262	6	0.039933484734206	0.517524576305591	0.674060960018038	0.599351183961286	0.78830058114649	0.53072632309686	0.540915325878243	NA	NA	0.540038458525641	0.575424736362367	0.598880924440345	0.600941478780111	0.627767477718288	0.577322492762775	0.572285611730801	NA	NA	0.596820370100579	0.601072228566161	NA	NA	p.Ala73Trp	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.712	-5.666	3.954	0.006198794	NA	NA	NA	NA	NA	NA	NA
A73X	73	A	X	nonsense	low	0.212373617557073	0.254894397816058	6	0.104060202157222	0.00841936910496133	0.416327866009184	-0.0442988576854514	-0.13955369119732	0.396554549780548	0.295305719547999	NA	NA	0.517309448499268	0.248924536397392	0.509290305119984	0.463844811692306	0.427154463604078	0.537176285214237	0.490938758985428	NA	NA	0.59214489740166	0.52764185125454	NA	NA	p.Ala73Ter	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A73Y	73	A	Y	missense	possibly_low	0.587724760798691	0.257331131588664	6	0.105054994554204	0.3818207550764	0.793628766520981	0.930311305175415	0.880556355013211	0.563573712728211	0.389310773160094	NA	NA	0.343845255054639	0.418751163660574	0.576493517579745	0.671435577469747	0.647714261837835	0.587150924548193	0.522073596778466	NA	NA	0.556462432580306	0.565836110611298	NA	NA	p.Ala73Tyr	0	19.7	13.4	23.4	0.096	22.6	-151.3	-48.1	116	12.396694214876	-4.7	0	0	12.53	0	0	0	0	8	9.82661502844979	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.712	-4.571	2.859	0.006198794	NA	NA	NA	NA	NA	NA	NA
V74A	74	V	A	missense	possibly_low	0.657335279898888	0.140278974848327	6	0.0572686516698528	0.545090785182807	0.769579774614969	0.778893627441278	0.86931697995991	0.632227852164524	0.506765447790903	NA	NA	0.540218196577281	0.616589575459433	0.609011767387053	0.639183798378091	0.645284176668849	0.607693273082104	0.560975039862094	NA	NA	0.596857343129867	0.610330261692003	NA	NA	p.Val74Ala	1	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.04	-3.326	1.286	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74C	74	V	C	missense	possibly_wt-like	0.830981276007448	0.313573666721318	6	0.128015913373463	0.580074696347461	1.08188785566744	0.731548128248251	0.383505114634478	1.11326634816922	1.26047541532144	NA	NA	0.705076585849568	0.792016063821733	0.640276744223082	0.629099265291811	0.540245933595191	0.751627208082823	0.810606699867229	NA	NA	0.630769550363524	0.649783938082639	NA	NA	p.Val74Cys	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.04	-4.266	2.226	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74D	74	V	D	missense	wt-like	0.915631595929673	0.106087697819626	6	0.043310121274109	0.830745318066357	1.00051787379299	0.989220856176174	0.851775663411117	0.953579959504453	0.773492653451814	NA	NA	1.06453469074475	0.861185752289732	0.674661771284623	0.683983239365613	0.64149153757748	0.703846644827549	0.649316123284168	NA	NA	0.704711906581074	0.665340303203632	NA	NA	p.Val74Asp	1	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.04	-4.257	2.217	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74E	74	V	E	missense	possibly_wt-like	0.725388871429704	0.175902383483818	6	0.0718118473457875	0.584640236968672	0.866137505890735	0.502355759086977	0.525935747844933	0.708380438694806	0.881595983720628	NA	NA	0.853485392409488	0.880579906821391	0.645888632223271	0.580281572600331	0.571041112840706	0.63047926948535	0.685120364901809	NA	NA	0.661297994961192	0.669702077208832	NA	NA	p.Val74Glu	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.04	-3.19	1.15	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74F	74	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val74Phe	1	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.04	-4.431	2.391	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74G	74	V	G	missense	possibly_low	0.661000778768693	0.158807594046569	6	0.0648329287821911	0.533930573343348	0.788070984194038	0.898208427445468	0.792910285575042	0.528438396770585	0.640735871333642	NA	NA	0.478500051129834	0.627211640357587	0.609032871361282	0.664597704004466	0.628764150069918	0.576637910880312	0.605346562942966	NA	NA	0.58416160742767	0.612719179779598	NA	NA	p.Val74Gly	1	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.04	-3.614	1.574	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74H	74	V	H	missense	possibly_wt-like	0.788701539946733	0.272311044387889	6	0.111170518345785	0.570811327846346	1.00659175204712	0.39430507095226	0.892363477146412	0.849030169364676	0.908879032493258	NA	NA	1.14407798698512	0.543553502738668	0.661415439835082	0.557266908945661	0.650267100607627	0.672563779062538	0.694156616309533	NA	NA	0.721074366253639	0.593904341040744	NA	NA	p.Val74His	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.04	-3.095	1.055	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74I	74	V	I	missense	wt-like	1.23566268224314	0.401340500577568	6	0.163846573254703	0.914529299673614	1.55679606481266	1.54100354570349	1.42940155292921	1.27357090976931	1.36568886730077	NA	NA	0.436427460908689	1.36788375684735	0.789445085464765	0.801512273462156	0.766381053291957	0.79959273795476	0.845453802604274	NA	NA	0.575507062125279	0.77929743297477	NA	NA	p.Val74Ile	1	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.04	-2.372	0.332	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74K	74	V	K	missense	possibly_low	0.417691383081627	0.400728994064875	6	0.163596926766289	0.0970472986382642	0.738335467524989	0.705258765997631	0.84256551962097	-0.110607420027275	-0.0497330307272021	NA	NA	0.590924428275008	0.527740035350629	0.598817870579299	0.623499663472159	0.639500196090741	0.385425814922473	0.376660588723859	NA	NA	0.607287872294695	0.590347868863902	NA	NA	p.Val74Lys	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.04	-3.039	0.999	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74L	74	V	L	missense	possibly_low	0.659579855085436	0.195088608755705	6	0.07964459101349	0.503479325135574	0.815680385035299	0.752321106101911	0.970451904834133	0.542005805427117	0.442083392053404	NA	NA	0.521438277903177	0.729178644192877	0.613259051291156	0.633523884020863	0.66715073773989	0.580697483101488	0.539552092519099	NA	NA	0.59299421856145	0.635651709578245	NA	NA	p.Val74Leu	1	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.04	-1.707	-0.333	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74M	74	V	M	missense	possibly_wt-like	0.737141197963346	0.309710864148145	6	0.126438930826566	0.489325447299526	0.984956948627167	0.382451903834362	0.570991386589076	0.767564811264928	1.10100447056503	NA	NA	0.496390966692409	1.10444364883427	0.618014990621669	0.554742198930665	0.580782672222086	0.648188121698465	0.75778930540904	NA	NA	0.587841859544873	0.720049363501951	NA	NA	p.Val74Met	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.04	-3.307	1.267	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74N	74	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val74Asn	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.04	-3.16	1.12	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74P	74	V	P	missense	possibly_wt-like	0.80823332744747	0.121277459736509	6	0.0495113156092297	0.711192932026183	0.905273722868756	0.755843717809842	0.969210534872373	0.858742590774277	0.881835333368732	NA	NA	0.762026450110699	0.621741337748894	0.654683382686614	0.634274195981329	0.666882338943784	0.675469881263256	0.685199638432148	NA	NA	0.642484426429445	0.611488900641613	NA	NA	p.Val74Pro	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.04	-3.65	1.61	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74Q	74	V	Q	missense	possibly_low	0.535728892152588	0.426331849414101	6	0.174049248693604	0.19459863317687	0.876859151128306	0.887206958515629	1.11199016948166	0.636840337502025	0.407440570577057	NA	NA	0.1878989675948	-0.0170036507556446	0.568575826893492	0.662254404655814	0.697752976399319	0.609073397895967	0.528078255891017	NA	NA	0.524383489913198	0.467834209107499	NA	NA	p.Val74Gln	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.04	-2.849	0.809	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74R	74	V	R	missense	wt-like	0.950667959169273	0.102471415190876	6	0.0418337800730878	0.868675256888852	1.03266066144969	0.853230883417632	1.0204350178132	0.947227253531669	0.950159792672693	NA	NA	0.829312257549771	1.10364255003067	0.689951747468107	0.655017542455443	0.677957675045048	0.701945819891167	0.707828963941646	NA	NA	0.656325458455962	0.719869195197556	NA	NA	p.Val74Arg	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.04	-2.453	0.413	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74S	74	V	S	missense	wt-like	0.87147442046576	0.0870970512503578	6	0.035557222277402	0.801783545411767	0.941165295519753	0.799496727944697	1.03100151362398	0.804405412122485	0.891640592685951	NA	NA	0.879158298229034	0.823143978188414	0.662895212078016	0.643572233440516	0.680242275802309	0.659211382192709	0.688447178289102	NA	NA	0.666579041963323	0.656784652009046	NA	NA	p.Val74Ser	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.04	-3.99	1.95	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74T	74	V	T	missense	possibly_wt-like	0.79400412325757	0.106699859619324	6	0.0435600352823233	0.708628022938923	0.879380223576218	0.812942936361025	0.895734940372541	0.768239816614603	0.863439532395127	NA	NA	0.828511622557005	0.59515589124512	0.649693072031951	0.646436259292407	0.650996050637743	0.648390093426159	0.679106877911532	NA	NA	0.656160763775193	0.605509794448173	NA	NA	p.Val74Thr	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.04	-3.561	1.521	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74V	74	V	V	synonymous	wt-like	1.08621342885812	0.265168064546538	6	0.108254409036736	0.874038685978446	1.29838817173778	0.767957109464263	1.01925850221529	1.36923744254443	1.43653805556052	NA	NA	0.884092039205423	1.04019742415876	0.691651795593522	0.636854333502491	0.677703298525712	0.828217599841208	0.868919328120999	NA	NA	0.667593937518029	0.705600292661332	NA	NA	p.Val74=	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74W	74	V	W	missense	possibly_low	0.554495875239789	0.279577530598056	6	0.114137048918765	0.330791370057324	0.778200380422254	0.850596310081992	0.921902617408589	0.350204122088511	0.411626775729563	NA	NA	0.22903464130483	0.563610784825249	0.565630280073816	0.654456381575859	0.656653810394896	0.523307541855668	0.529464743248702	NA	NA	0.532845306734947	0.598415253412685	NA	NA	p.Val74Trp	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.04	-5.759	3.719	0.007578954	NA	NA	NA	NA	NA	NA	NA
V74X	74	V	X	nonsense	low	0.215229244207787	0.344182134704005	6	0.140511768101113	-0.0601687606744387	0.490627249090013	0.078023772519202	-0.202024665033802	0.176830944160238	0.205383079261527	NA	NA	0.187808294465929	0.845354039873629	0.480665533680931	0.489899381451312	0.413647503804961	0.47143168591055	0.461156032295075	NA	NA	0.524364837990476	0.661779727693026	NA	NA	p.Val74Ter	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V74Y	74	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val74Tyr	0	19.4	14.3	27.1	0.755	88.5	75	-63.8	-21	7.27272727272727	-2.7	0	0	13.98	0	0	0	0	6	13.6404231875531	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.04	-3.684	1.644	0.007578954	NA	NA	NA	NA	NA	NA	NA
E75A	75	E	A	missense	possibly_low	0.549892404668581	0.266223228776327	6	0.108685178029705	0.336873370077034	0.762911439260127	0.783165542653114	0.855856009114061	0.232324064190846	0.246989659518829	NA	NA	0.662775475554744	0.51824367697989	0.605140060579851	0.640093711063137	0.642373756342317	0.488036059984168	0.474936292798723	NA	NA	0.622067997322371	0.588212123837331	NA	NA	p.Glu75Ala	1	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.754	-3.548	1.794	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75C	75	E	C	missense	low	0.528802654148592	0.22239701606401	6	0.0907932016123966	0.35085124894721	0.706754059349973	0.708129265489407	0.740620758752647	0.608601681046812	0.611499684296688	NA	NA	0.208327459501514	0.295637075804481	0.598143696399983	0.624111076332776	0.617458538946365	0.600623968221439	0.595663424578527	NA	NA	0.528585734361112	0.538147570375737	NA	NA	p.Glu75Cys	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.754	-5.438	3.684	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75D	75	E	D	missense	possibly_low	0.712112568915666	0.253350496651803	5	0.113301786529353	0.490045147934089	0.934179989897243	0.751849568432529	0.933744655898614	0.375426929345902	0.53781262547773	NA	NA	0.961729065423554	NA	0.633423447077345	0.633423447077345	0.659214198491983	0.530854584203575	0.571257985342874	NA	NA	0.683564267773808	NA	NA	NA	p.Glu75Asp	1	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.754	-0.773	-0.981	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75F	75	E	F	missense	low	0.521436959056731	0.173458199597012	6	0.0708140134524197	0.382644043089253	0.660229875024208	0.67768025317793	0.786069739297766	0.422774939877772	0.49302334584107	NA	NA	0.40841432953556	0.340659146610285	0.5630841106656	0.617625474167135	0.627285143454574	0.545021819314507	0.556423602479706	NA	NA	0.569744618851494	0.548273100611171	NA	NA	p.Glu75Phe	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.754	-4.595	2.841	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75G	75	E	G	missense	possibly_low	0.624393046889785	0.179883608525335	6	0.0734371756629387	0.480458827464084	0.768327266315486	0.836459151111309	0.829489458496861	0.641554237181855	0.550680451580452	NA	NA	0.399333984990686	0.488840997977548	0.596041642647814	0.65144518410586	0.636672997776266	0.61048386740257	0.575519859179045	NA	NA	0.567876745901151	0.581599417893059	NA	NA	p.Glu75Gly	1	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.754	-3.474	1.72	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75H	75	E	H	missense	possibly_wt-like	0.819640152874883	0.16515788737439	6	0.067425425177218	0.687488747885235	0.95179155786453	0.558874042150132	0.944917931229988	0.901096995351539	0.925675061233227	NA	NA	0.664291321882801	0.922985565401608	0.670434582296312	0.592319897367093	0.661629992123124	0.688142954553752	0.699719526071214	NA	NA	0.62237981460409	0.6792391724695	NA	NA	p.Glu75His	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.754	-4.682	2.928	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75I	75	E	I	missense	possibly_low	0.677788309561124	0.127008291845427	6	0.0518509180206308	0.576162377675349	0.779414241446899	0.702097182627532	0.910751166494117	0.685482789864343	0.583789103868493	NA	NA	0.62609092079917	0.558518693713089	0.618674024179963	0.622826250103534	0.654242735459553	0.623627949423014	0.586485573030854	NA	NA	0.614521798256391	0.597270034599003	NA	NA	p.Glu75Ile	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.754	-4.313	2.559	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75K	75	E	K	missense	possibly_low	0.640311247100649	0.442855883193356	6	0.180795157235552	0.285959250339711	0.994663243861587	0.160396831477343	0.470955712022527	0.831213867721877	1.03905640865706	NA	NA	1.18217145346693	0.158073209258157	0.613193328159598	0.50744474167858	0.559153782005253	0.667232874313944	0.73727186740984	NA	NA	0.728910385611111	0.507209253566052	NA	NA	p.Glu75Lys	1	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.754	-3.628	1.874	0.00156997	NA	NA	NA	NA	2.03e-05	NA	NA
E75L	75	E	L	missense	low	0.479891976850228	0.233954669610168	6	0.0955115939143892	0.29269269267201	0.667091261028446	0.732274518597409	0.732233267521572	0.472035153655027	0.499598941805934	NA	NA	0.30042894953033	0.142781029991096	0.55918133982628	0.629253985542616	0.615645064625153	0.559761214325146	0.558601465327414	NA	NA	0.547531478221482	0.503770019857718	NA	NA	p.Glu75Leu	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.754	-4.045	2.291	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75M	75	E	M	missense	wt-like	0.886409639070234	0.16072171363194	6	0.0656143648306622	0.757807847133664	1.0150114310068	1.08160682621851	1.08919008461342	0.791770035187414	0.702607899180345	NA	NA	0.831706018515637	0.821576970706078	0.656625048472454	0.703661337336481	0.692823329703913	0.655430687845818	0.625838818166632	NA	NA	0.656817867233584	0.656432229711325	NA	NA	p.Glu75Met	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.754	-5.167	3.413	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75N	75	E	N	missense	possibly_wt-like	0.856371736391954	0.312011342653682	6	0.1273780972437	0.60671525337506	1.10602821940885	0.519839842138858	0.431710578074631	0.859010008383523	1.12848939360401	NA	NA	1.11957850896853	1.07960208718217	0.695006178105946	0.584005660782422	0.550668522147888	0.675549896623995	0.766892418355542	NA	NA	0.716034699305038	0.714462459587897	NA	NA	p.Glu75Asn	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.754	-3.026	1.272	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75P	75	E	P	missense	low	0.509282136279151	0.206120806611059	6	0.0841484669279972	0.344354171746016	0.674210100812285	0.578167796223962	0.86967409714434	0.376777741529242	0.527384081284803	NA	NA	0.423757877987521	0.279931223505038	0.570352437874519	0.596429443250702	0.645361389607234	0.531258767474997	0.567804011121401	NA	NA	0.572900864627638	0.5346153009913	NA	NA	p.Glu75Pro	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.754	-3.965	2.211	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75Q	75	E	Q	missense	possibly_low	0.583603936682576	0.207912389802913	6	0.0848798777032954	0.417242433371953	0.7499654399932	0.896834612336615	0.739340874191405	0.61585676220952	0.431216559656447	NA	NA	0.343362071038547	0.475012740662924	0.59064210987371	0.664305083076273	0.617181812840551	0.602794797352936	0.535952955547171	NA	NA	0.556363039176319	0.578489422394484	NA	NA	p.Glu75Gln	1	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.754	-3.853	2.099	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75R	75	E	R	missense	low	0.0678736712187815	0.0913559837678474	6	0.0372959241968681	-0.00522499697721591	0.140972339414779	-0.0933161317284066	0.171542943973313	0.103805465517822	0.0422118474520124	NA	NA	0.0604009010405405	0.122597001057407	0.473910705108487	0.453404192619516	0.494417217597459	0.449581367103194	0.40711308843545	NA	NA	0.498156490644527	0.499230601932619	NA	NA	p.Glu75Arg	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.754	-4.094	2.34	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75S	75	E	S	missense	possibly_low	0.662826311182741	0.207029737012285	6	0.0845195362104483	0.497171064220233	0.828481558145249	0.805782889902229	0.995986941505845	0.561097015078685	0.493096609459448	NA	NA	0.453786245504016	0.667208165646223	0.604062158428829	0.644911178204579	0.672671713204376	0.586409859453686	0.556447867673827	NA	NA	0.579077852202264	0.621714457403972	NA	NA	p.Glu75Ser	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.754	-3.454	1.7	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75T	75	E	T	missense	low	0.489956933701847	0.0986590798148605	6	0.0402774006731546	0.411014678991574	0.568899188412119	0.387419779571367	0.615435430132042	0.606404228596671	0.48312900678313	NA	NA	0.426556255392135	0.420796901735734	0.569886352593239	0.555800350351439	0.590391997522766	0.59996645748009	0.553146559067663	NA	NA	0.573476505059903	0.566296200126575	NA	NA	p.Glu75Thr	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.754	-3.715	1.961	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75V	75	E	V	missense	possibly_low	0.702007384724054	0.0693100756351851	6	0.0282957198899854	0.646548792823049	0.757465976625059	0.686426577231314	0.803198230522595	0.756626265367142	0.670321764644007	NA	NA	0.604962732238648	0.690508738340618	0.623221610528095	0.619488430431258	0.630988524852131	0.644915144655399	0.615145525379405	NA	NA	0.610175622656236	0.626954790624931	NA	NA	p.Glu75Val	1	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.754	-3.999	2.245	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75W	75	E	W	missense	possibly_low	0.620710377782515	0.15648260274192	6	0.0638837550567248	0.495500518674156	0.745920236890874	0.826795707670593	0.794741213477653	0.587044838953805	0.578291463570757	NA	NA	0.45248100965788	0.484908033364401	0.589419285462756	0.649386882540426	0.629160018231673	0.594173837651005	0.584664733274507	NA	NA	0.578809358565402	0.580714888341384	NA	NA	p.Glu75Trp	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.754	-5.793	4.039	0.00156997	NA	NA	NA	NA	NA	NA	NA
E75X	75	E	X	nonsense	low	0.333551341918343	0.195267345032532	6	0.0797175597929486	0.177307795788745	0.489794888047941	0.122477414162907	0.127402685565292	0.632080161941837	0.442005812797655	NA	NA	0.302181548370724	0.375160428671644	0.543709197332769	0.499367952436991	0.48487357421837	0.607649081951687	0.539526397969167	NA	NA	0.54789199669637	0.556032489915594	NA	NA	p.Glu75Ter	1	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E75Y	75	E	Y	missense	possibly_low	0.61779211528947	0.169978753666761	6	0.0693935355996332	0.481783284754291	0.753800945824649	0.560466816737706	0.898810017807086	0.687260329611887	0.468037744602636	NA	NA	0.4350219676246	0.657155815352905	0.606056412683774	0.592659156394903	0.65166091857139	0.624159815983818	0.548148274592226	NA	NA	0.575217945024682	0.619453668972644	NA	NA	p.Glu75Tyr	0	21.8	17.2	26.6	0.68	78.3	73.6	-70	-17.4	3.27102803738318	-2.4	1	0	13.48	1	29	0	0	6	14.3391834181439	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.754	-4.625	2.871	0.00156997	NA	NA	NA	NA	NA	NA	NA
M76A	76	M	A	missense	low	0.538872530269447	0.180117795010225	6	0.0735327818950447	0.394750926072121	0.682994134466774	0.680560511259885	0.832943363310936	0.46224075642064	0.447686602888407	NA	NA	0.352103112547821	0.457700835188993	0.566378532524476	0.618238965595456	0.637419772647997	0.556830583727773	0.541407897646214	NA	NA	0.558161115770473	0.574595949278479	NA	NA	p.Met76Ala	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-1.384	-3.515	2.131	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76C	76	M	C	missense	low	0.556407860854621	0.0784118395494576	6	0.0320114994481928	0.493666474845039	0.619149246864202	0.590542196615023	0.634841004403696	0.548318060544397	0.53014426721907	NA	NA	0.418277514782853	0.616324121562685	0.588586957805163	0.59906517531169	0.594587711075304	0.582586204535022	0.568718195391713	NA	NA	0.571773526106785	0.610270560718468	NA	NA	p.Met76Cys	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-1.384	-5.105	3.721	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76D	76	M	D	missense	low	-0.0926756684318476	0.226613157057706	6	0.0925144339654273	-0.274000627054194	0.0886492901904989	-0.00317969346965861	-0.0702848291485759	-0.408517634675241	-0.293469173241498	NA	NA	-0.00491333488909363	0.224310654832981	0.457367174965274	0.472603143087731	0.442131206842817	0.296286609167989	0.295934234449358	NA	NA	0.484721020882078	0.52210615292856	NA	NA	p.Met76Asp	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-1.384	-4.392	3.008	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76E	76	M	E	missense	low	0.133313203263253	0.123061523088687	6	0.0502396564228357	0.0348452860788292	0.231781120447678	0.174691346089752	0.240655065870961	0.2633729561288	0.149841830328312	NA	NA	0.0147623616867447	-0.0434443405250493	0.493047382893693	0.510489455706696	0.509360071770769	0.497326354276952	0.442760555563642	NA	NA	0.488768411510434	0.461887658917468	NA	NA	p.Met76Glu	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-1.384	-4.191	2.807	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76F	76	M	F	missense	low	0.201836771875248	0.265091832651461	6	0.108223287495891	-0.0102769739052226	0.413950517655719	0.571447372015421	0.475536966593388	0.113289474399158	0.156948673663471	NA	NA	-0.0542366602542455	-0.0519651951657028	0.467273134344106	0.59499800116138	0.560144303162808	0.452419124848593	0.445114369597659	NA	NA	0.474574962567306	0.459971306120907	NA	NA	p.Met76Phe	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-1.384	-3.311	1.927	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76G	76	M	G	missense	low	0.131192907348815	0.0541416663799664	6	0.0221032427424861	0.0878713476319954	0.174514467065634	0.070084853662625	0.08222482562945	0.174817812357793	0.118981079080722	NA	NA	0.211623910239073	0.129424963123224	0.48165699533887	0.488208401500883	0.475105589176857	0.470829326672344	0.432539355241478	NA	NA	0.529263831005397	0.500766220688185	NA	NA	p.Met76Gly	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-1.384	-4.11	2.726	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76H	76	M	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met76His	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-1.384	-5.224	3.84	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76I	76	M	I	missense	possibly_wt-like	0.793656541927216	0.110662434306969	6	0.0451777496243895	0.705109779760844	0.882203304093587	0.644704390246881	0.908313371156568	0.884293017284974	0.708464588219823	NA	NA	0.737339042120465	0.878824842534583	0.645560878373717	0.610601655927918	0.653715655415804	0.683114952207007	0.627778576256669	NA	NA	0.63740610133163	0.669307360657968	NA	NA	p.Met76Ile	1	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-1.384	-1.829	0.445	0.006686039	NA	NA	NA	NA	4.06e-06	NA	NA
M76K	76	M	K	missense	low	0.131079574675759	0.191901785430375	6	0.0783435758389135	-0.0224710123885935	0.284630161740112	0.23487113244142	-0.0224085259182882	0.357739183252132	0.272410669081783	NA	NA	-0.145956328385795	0.0898213175833037	0.487607565954556	0.523307676169732	0.452482627084071	0.525562145203964	0.483355829609412	NA	NA	0.455707761408728	0.4918593022997	NA	NA	p.Met76Lys	1	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-1.384	-3.489	2.105	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76L	76	M	L	missense	possibly_low	0.584941990526088	0.217041197193798	6	0.0886066977145984	0.411276054216448	0.758607926835728	0.906181260948437	0.805257005022359	0.460309650741648	0.524196010128797	NA	NA	0.430802690166394	0.382905326148894	0.570549063924903	0.666295907732857	0.631433656129843	0.556252767936339	0.566748109608654	NA	NA	0.574350018241152	0.557774328799783	NA	NA	p.Met76Leu	1	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-1.384	-1.566	0.182	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76N	76	M	N	missense	low	0.250039714485432	0.205415963053328	6	0.0838607157505093	0.0856757318966832	0.414403697074181	-0.0314113015684245	0.0418682918728217	0.398644617028667	0.497189532177339	NA	NA	0.276278767244563	0.317668380157627	0.540182663934616	0.466589845291668	0.466380031600161	0.537801664692047	0.55780345952793	NA	NA	0.542563663177184	0.543102443271656	NA	NA	p.Met76Asn	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-1.384	-4.433	3.049	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76P	76	M	P	missense	low	0.290977872466483	0.188595018613828	6	0.0769935939390958	0.140073201305554	0.441882543627412	0.57693928255438	0.464059038384485	0.234993185693322	0.175890800233244	NA	NA	0.082702215465227	0.211282712468241	0.510960066816196	0.596167771350331	0.557662639993916	0.488834701182403	0.451388075271385	NA	NA	0.502743984187872	0.519176149444521	NA	NA	p.Met76Pro	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-1.384	-4.435	3.051	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76Q	76	M	Q	missense	low	0.272081747830112	0.251658129227107	6	0.1027390010383	0.0707170059874203	0.473446489672804	0.684088490605802	0.386905779055294	0.145057299493895	0.311344225469893	NA	NA	-0.0465926965593164	0.151687388915105	0.501011923696675	0.61899042085621	0.540981197267284	0.461924534728004	0.496250774256239	NA	NA	0.476147364688018	0.505773073137112	NA	NA	p.Met76Gln	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-1.384	-4.385	3.001	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76R	76	M	R	missense	low	0.13258307970989	0.128758372307231	6	0.0525653853773367	0.0295568175368419	0.235609341882939	0.0110625829880464	0.0744519788695193	0.275815045222787	0.315509352290927	NA	NA	0.063666877299015	0.0549926415890466	0.490828281002511	0.475636730453155	0.473425008224399	0.501049214001903	0.497630280388914	NA	NA	0.498828318533823	0.484026281616109	NA	NA	p.Met76Arg	1	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-1.384	-4.31	2.926	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76S	76	M	S	missense	low	0.135281786375925	0.459519307621859	6	0.187597971771762	-0.23240348186949	0.50296705462134	0.704705597521054	0.71555266249703	-0.0195996305337104	-0.0537084041635023	NA	NA	-0.339918205604494	-0.195341301460826	0.421767313513259	0.623381839267126	0.61203852149552	0.412656710924189	0.375343929647032	NA	NA	0.415808819021236	0.427725808005281	NA	NA	p.Met76Ser	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-1.384	-3.43	2.046	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76T	76	M	T	missense	low	0.334395293515485	0.157293994440839	6	0.0642150043307048	0.20853619776022	0.46025438927075	0.494144047919759	0.428880957248774	0.495487980446956	0.20968654147956	NA	NA	0.136516362986099	0.241655871011764	0.538031921246626	0.57853248822331	0.550056724821955	0.56677865196286	0.462581355646943	NA	NA	0.513813827408384	0.526007117671297	NA	NA	p.Met76Thr	1	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-1.384	-3.859	2.475	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76V	76	M	V	missense	low	0.398929125631767	0.292764099576502	6	0.119520443161299	0.164673361619354	0.63318488964418	0.691688446449759	0.761874030549812	0.152632251730132	0.469337649941089	NA	NA	0.0357614654616026	0.282280909658208	0.54186127857629	0.620609202101924	0.6220537464505	0.464191074083709	0.548578808274235	NA	NA	0.493088033715148	0.535143748878345	NA	NA	p.Met76Val	1	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-1.384	-2.72	1.336	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76W	76	M	W	missense	low	0.519555108894196	0.148094208833765	6	0.060459207583983	0.401057239495758	0.638052978292633	0.666366240234325	0.72920749782322	0.453497426509314	0.488457349629073	NA	NA	0.338906887909024	0.440895251260217	0.563131467012542	0.615215603328025	0.614990857604401	0.55421444824257	0.554911326852368	NA	NA	0.555446585399115	0.570816348625969	NA	NA	p.Met76Trp	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-1.384	-5.481	4.097	0.006686039	NA	NA	NA	NA	NA	NA	NA
M76X	76	M	X	nonsense	low	-0.0246340999096626	0.184670939706971	6	0.0753915954337261	-0.17239891169678	0.123130711877455	-0.147586195534897	-0.274593088080803	-0.103581231181751	0.0256193407485887	NA	NA	0.134223019228122	0.218113555362765	0.421731160874601	0.441844735788787	0.397957356644029	0.387528156038609	0.401617585960416	NA	NA	0.513342074959984	0.520712416102719	NA	NA	p.Met76Ter	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M76Y	76	M	Y	missense	low	0.478160977470544	0.0508472805864633	6	0.02075831537416	0.437475426957466	0.518846527983622	0.530241740058295	0.504658146040229	0.456380168330172	0.428064554512163	NA	NA	0.531846664870888	0.417774591011518	0.56602856144121	0.586221252243418	0.566440644902588	0.555077007845	0.534908999237172	NA	NA	0.595135276577212	0.565616477979832	NA	NA	p.Met76Tyr	0	19.1	19.2	24.9	0.918	97.1	49.2	-59.4	-38.1	0	-4.1	1	0	14.56	0	0	0	0	7	13.9075446891603	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-1.384	-4.354	2.97	0.006686039	NA	NA	NA	NA	NA	NA	NA
K77A	77	K	A	missense	wt-like	1.00866750076796	0.0871366157112743	6	0.0355733744009343	0.93894496813357	1.07839003340235	0.880604639532042	0.960698116804341	1.08555843885021	1.12069123232536	NA	NA	1.02117727191751	0.983275305178294	0.69429574476305	0.66084811883412	0.665041853970088	0.74333658591422	0.764309637141496	NA	NA	0.695793065514653	0.692798424011448	NA	NA	p.Lys77Ala	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.296	-2.283	-0.013	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77C	77	K	C	missense	wt-like	1.26598824364429	0.0987007821063657	6	0.04029442556237	1.18701262076431	1.34496386652426	1.12765779958649	1.19099942633446	1.3004557830644	1.26194680500113	NA	NA	1.41230416361071	1.30256548426853	0.770428554427085	0.713470138014482	0.714835707634824	0.807637095397039	0.811094029827133	NA	NA	0.776249851877212	0.764607256976959	NA	NA	p.Lys77Cys	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.296	-3.948	1.652	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77D	77	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys77Asp	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.296	-3.414	1.118	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77E	77	K	E	missense	low	0.564321805063831	0.127396042452793	6	0.0520092165432144	0.462385613774986	0.666257996352676	0.445311628965752	0.669311436691347	0.631455728514352	0.573069336554751	NA	NA	0.690658072773526	0.376124626883257	0.592487884410801	0.568131243057067	0.602040624237602	0.60746224210184	0.582935144584	NA	NA	0.627803589058223	0.556249339517798	NA	NA	p.Lys77Glu	1	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.296	-3.705	1.409	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77F	77	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys77Phe	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.296	-4.058	1.762	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77G	77	K	G	missense	wt-like	0.854659904986663	0.100464325458217	6	0.0410143891209221	0.774273179461744	0.935046630511581	0.878481499132297	0.9767434413591	0.882967462727861	0.92265408999003	NA	NA	0.744440711568762	0.722672225141926	0.664453467262965	0.660395892540745	0.668511041985184	0.682718326396291	0.698718968696687	NA	NA	0.638866950773983	0.634188406321738	NA	NA	p.Lys77Gly	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.296	-2.741	0.445	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77H	77	K	H	missense	possibly_wt-like	0.902357462151545	0.294539496196175	5	0.131722067110638	0.644186954645527	1.16052796965756	1.32808996453232	0.932360895768995	0.604371926916425	NA	NA	NA	0.645117865118181	1.0018466584218	0.658915013265716	0.756161942587297	0.658915013265716	0.599358362326841	NA	NA	NA	0.618435737253477	0.696975148791415	NA	NA	p.Lys77His	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.296	-2.937	0.641	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77I	77	K	I	missense	possibly_low	0.404519481074499	0.596272635410992	6	0.24342728405692	-0.0725892285314648	0.881628190680464	1.0981374738552	1.21357233230937	0.265148325431221	-0.00486663295493375	NA	NA	-0.0681958643487351	-0.0766787478451239	0.484780527429123	0.707182344948002	0.719716235579694	0.497857571408012	0.391520513412182	NA	NA	0.471703483450235	0.454413191613917	NA	NA	p.Lys77Ile	1	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.296	-2.613	0.317	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77K	77	K	K	synonymous	possibly_low	0.646106213676144	0.178288103893032	6	0.0727858136243739	0.503448640386926	0.788763786965362	0.879098510520075	0.835182956709377	0.657732285298109	0.530386867987216	NA	NA	0.536196780598196	0.438039880943891	0.605677349787006	0.660527315207328	0.637903999099762	0.615324582117387	0.5687985457056	NA	NA	0.596030117456624	0.570174171623582	NA	NA	p.Lys77=	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77L	77	K	L	missense	wt-like	0.950959144258212	0.116371232847412	6	0.047508356869128	0.857844475830045	1.04407381268638	1.1500205419014	0.8782962722179	0.987579387206426	0.966769857896794	NA	NA	0.810431912234709	0.912656894092041	0.695123260450066	0.718233374618139	0.647225605337316	0.714019783687665	0.713330281866724	NA	NA	0.652441675617893	0.676916239033408	NA	NA	p.Lys77Leu	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.296	-2.305	0.009	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77M	77	K	M	missense	wt-like	0.971369516868932	0.204739605367398	3	0.118206466272645	0.739689100234799	1.20304993350307	0.737946936174421	1.05561959771263	NA	1.12054201671974	NA	NA	NA	NA	0.685564995326213	0.630462203508623	0.685564995326213	NA	0.764260216355074	NA	NA	NA	NA	NA	NA	p.Lys77Met	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.296	-3.536	1.24	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77N	77	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys77Asn	1	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.296	-3.442	1.146	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77P	77	K	P	missense	possibly_low	0.486883453496266	0.298698965942148	6	0.121943342209205	0.24787889461178	0.725888012380751	0.836830773870155	0.847256612574544	0.433868045553438	0.441987678741494	NA	NA	0.207367594972876	0.153990015265088	0.543930717430755	0.651524339296345	0.640514465599388	0.548341042961967	0.539520391899542	NA	NA	0.528388285356818	0.506290937204898	NA	NA	p.Lys77Pro	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.296	-3.491	1.195	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77Q	77	K	Q	missense	wt-like	0.976804670255253	0.131374383638621	6	0.0536333675312108	0.871685201524479	1.08192413898603	0.761005944457975	1.07020344992767	0.900889507340052	0.95635481459925	NA	NA	1.06505237278322	1.10732193242335	0.696768296111951	0.635373743907093	0.688718195820579	0.688080871027783	0.709880779194085	NA	NA	0.704818396403324	0.720696693733229	NA	NA	p.Lys77Gln	1	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.296	-3.656	1.36	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77R	77	K	R	missense	wt-like	0.946631184597779	0.070285730472792	6	0.0286940293095212	0.890391920579781	1.00287044861578	0.95803348168922	0.989576235454755	0.902719136044769	1.022222861518	NA	NA	0.979061184607145	0.828174208272787	0.682234969802587	0.677340366964888	0.671285643104963	0.688628323386061	0.731696531409087	NA	NA	0.687129572640287	0.657915958186192	NA	NA	p.Lys77Arg	1	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.296	-2.806	0.51	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77S	77	K	S	missense	possibly_wt-like	0.7815847157466	0.239276450421056	6	0.0976842018326572	0.590127198296051	0.97304223319715	0.970006413541147	1.16123429542726	0.679163720505795	0.746299820783464	NA	NA	0.600219855570309	0.532584188651625	0.631023470432903	0.679890586720905	0.70840013601029	0.62173718906626	0.640309751799547	NA	NA	0.60919998885822	0.591437326097575	NA	NA	p.Lys77Ser	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.296	-2.882	0.586	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77T	77	K	T	missense	wt-like	0.902023264711548	0.0469836241245974	6	0.0191809842286636	0.864429226435336	0.939617302987759	0.959991609283289	0.87457018025903	0.844777502561633	0.863883376206309	NA	NA	0.927844395510394	0.941072524448632	0.677175732480671	0.677757445733643	0.646419980401358	0.671291317352524	0.679253880700591	NA	NA	0.676594019227698	0.683306956279082	NA	NA	p.Lys77Thr	1	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.296	-3.309	1.013	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77V	77	K	V	missense	wt-like	0.989365981691608	0.0668804313278341	6	0.0273038217550741	0.935851474411362	1.04288048897185	0.986932982090898	1.11656922388187	0.988773319993243	0.948519773910219	NA	NA	0.924923625581854	0.970476964691562	0.694331540091524	0.683495924999866	0.698743021854085	0.714377026289994	0.707285783376504	NA	NA	0.675993202032191	0.689920058328964	NA	NA	p.Lys77Val	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.296	-2.441	0.145	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77W	77	K	W	missense	low	0.438406833575281	0.23947349666013	6	0.0977646456229017	0.246791649193072	0.630022017957489	0.53620951220828	0.809073356531054	0.42636460553843	0.466619307270208	NA	NA	0.0926460953993843	0.299528124504327	0.546887191895271	0.58749238037014	0.632258796242788	0.546095901135747	0.547678482654795	NA	NA	0.504789490749729	0.539022672976587	NA	NA	p.Lys77Trp	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.296	-4.015	1.719	0.008429701	NA	NA	NA	NA	NA	NA	NA
K77X	77	K	X	nonsense	low	-0.228379531640481	0.181716463967733	6	0.0741854357639653	-0.373780313915263	-0.0829787493656993	0	-0.169520267764145	-0.10483427551682	-0.215790157263666	NA	NA	-0.392958435415294	-0.487174053882961	0.396025700487531	0.473280413885284	0.420675337057008	0.387153226374195	0.321661825354975	NA	NA	0.404898174600867	0.362092190860346	NA	NA	p.Lys77Ter	1	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K77Y	77	K	Y	missense	low	0.479710907516445	0.218140997033902	6	0.089055689119173	0.30516496422447	0.654256850808419	0.698177969768298	0.814094611147702	0.37772947948666	0.317734313292352	NA	NA	0.332022854705123	0.338506216698533	0.550909704165051	0.621991462585718	0.633344450588848	0.531543541750733	0.498367196088798	NA	NA	0.554030504836612	0.54778890349349	NA	NA	p.Lys77Tyr	0	17.5	19.7	28.3	0.832	102.3	63	-71.4	-28.8	19.5652173913043	-4.6	1	0	15.2	0	0	1	4	8	17.1338638429889	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.296	-4.636	2.34	0.008429701	NA	NA	NA	NA	NA	NA	NA
W78A	78	W	A	missense	possibly_low	0.621218088403089	0.245250534170769	6	0.100123111310566	0.424980396214285	0.817455780591892	0.826768908914126	1.00972391263822	0.529422466455129	0.531321121815441	NA	NA	0.469905218484221	0.360166902111395	0.579662983016285	0.649381174438265	0.675641808041257	0.576932359293875	0.569107974191427	NA	NA	0.582393606738696	0.552660423642223	NA	NA	p.Trp78Ala	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	148	-0.9	1.8	-2.7	264	121	143	5.4	8.1	-2.7	204	89	115	5.89	6	0.11	-1.007	-3.229	2.222	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78C	78	W	C	missense	wt-like	0.906444135213779	0.225800758066412	6	0.0921827734660569	0.725769219225293	1.08711905120227	0.899981439648025	0.935281466746075	0.641920923449251	0.71800314888102	NA	NA	1.28887708246613	0.954600750092169	0.662260914253668	0.664975353422549	0.659546475084786	0.61059358543515	0.630937784485951	NA	NA	0.750860274965193	0.686349474211592	NA	NA	p.Trp78Cys	1	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	215	-0.9	2.5	-3.4	264	148	116	5.4	5.5	-0.0999999999999996	204	121	83	5.89	5.07	-0.82	-1.007	-5.239	4.232	0.004032037	NA	NA	NA	NA	1.22e-05	NA	NA
W78D	78	W	D	missense	possibly_wt-like	0.857695599871028	0.191564341482738	6	0.0782058149241635	0.704415019238062	1.01097618050399	0.954409931458748	1.11664754398004	0.537496551945703	0.800305361423342	NA	NA	0.846147836158889	0.891166374259445	0.66593580589084	0.67656855522329	0.698759955581101	0.579348246807749	0.658196595997161	NA	NA	0.659788622406617	0.672082989375063	NA	NA	p.Trp78Asp	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	181	-0.9	-3.5	2.6	264	187	77	5.4	13	-7.6	204	133	71	5.89	5.05	-0.84	-1.007	-4.317	3.31	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78E	78	W	E	missense	possibly_low	0.703851121680409	0.092577508931338	6	0.0377946097566218	0.629775047747685	0.777927195613134	0.739162635493342	0.872312690256188	0.675096604079759	0.610949932986238	NA	NA	0.648691230965284	0.676893636301645	0.622206490437797	0.630721145968066	0.645931884493087	0.620520246812849	0.595481344815581	NA	NA	0.619170796740978	0.623892734062744	NA	NA	p.Trp78Glu	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	152	-0.9	-3.5	2.6	264	214	50	5.4	12.3	-6.9	204	147	57	5.89	3.22	-2.67	-1.007	-3.446	2.439	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78F	78	W	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp78Phe	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	40	-0.9	2.8	-3.7	264	228	36	5.4	5.2	0.2	204	165	39	5.89	3.32	-2.57	-1.007	-2.488	1.481	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78G	78	W	G	missense	low	0.366665267778747	0.300229947340608	6	0.122568362747859	0.126435691148903	0.606894844408591	0.785347645138749	0.657459881548845	0.250812727266011	0.367913907922484	NA	NA	0.0538453126672358	0.0846121321291583	0.505897422501132	0.640558496208274	0.599478178528243	0.49356814536073	0.514986872151921	NA	NA	0.496807972850343	0.490687748795521	NA	NA	p.Trp78Gly	1	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	184	-0.9	-9.4	8.5	264	97	167	5.4	9	-3.6	204	75	129	5.89	3.29	-2.6	-1.007	-3.776	2.769	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78H	78	W	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp78His	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	115	-0.9	-3.2	2.3	264	216	48	5.4	10.4	-5	204	155	49	5.89	7.59	1.7	-1.007	-4.783	3.776	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78I	78	W	I	missense	possibly_low	0.476820559242295	0.32746468550892	6	0.133686898046303	0.214799053866663	0.738842064617927	0.169659564168486	0.0103768716022999	0.85226573920359	0.563812778722909	NA	NA	0.749256120305375	0.515552281451112	0.583738080895383	0.509417692347289	0.459571215897617	0.673531910101431	0.579869336783863	NA	NA	0.6398575047865	0.587606825006904	NA	NA	p.Trp78Ile	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	61	-0.9	4.5	-5.4	264	191	73	5.4	5.2	0.2	204	131	73	5.89	6.02	0.13	-1.007	-4.186	3.179	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78K	78	W	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp78Lys	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	110	-0.9	-3.9	3	264	230	34	5.4	11.3	-5.9	204	146	58	5.89	9.74	3.85	-1.007	-4.118	3.111	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78L	78	W	L	missense	possibly_wt-like	0.727782023535106	0.0771111672151837	6	0.0314805021912718	0.666081373024979	0.789482674045233	0.75838650359663	0.816764183454686	0.647713989878797	0.702048217695254	NA	NA	0.638100516449239	0.80367873013603	0.629787546516346	0.634815806225919	0.633921643541301	0.612326957823951	0.62565344949139	NA	NA	0.616992233023317	0.652406888966009	NA	NA	p.Trp78Leu	1	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	61	-0.9	3.8	-4.7	264	191	73	5.4	4.9	0.5	204	131	73	5.89	9.71	3.82	-1.007	-3.642	2.635	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78M	78	W	M	missense	possibly_wt-like	0.755833687259899	0.152599340263913	6	0.0622984197886559	0.633731028180376	0.877936346339422	0.834840288477864	0.986987826402654	0.601736052834331	0.822114233132767	NA	NA	0.600497550427038	0.688826172284737	0.638838373694839	0.651100368356373	0.670725998603471	0.598569669255594	0.665419778762676	NA	NA	0.609257112099389	0.626576379033304	NA	NA	p.Trp78Met	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	67	-0.9	1.9	-2.8	264	203	61	5.4	5.7	-0.3	204	149	55	5.89	5.74	-0.15	-1.007	-4.85	3.843	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78N	78	W	N	missense	low	0.594227610187503	0.130927399416471	6	0.0534508869866535	0.489465796751942	0.698989423623065	0.507970790768416	0.423898597185828	0.685231653661049	0.516396349088858	NA	NA	0.767379788206208	0.664488482214661	0.601290182011796	0.581477567441174	0.548979479936177	0.623552805703205	0.564164831667861	NA	NA	0.643585635240765	0.621102796582419	NA	NA	p.Trp78Asn	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	174	-0.9	-3.5	2.6	264	187	77	5.4	11.6	-6.2	204	132	72	5.89	5.47	-0.42	-1.007	-4.463	3.456	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78P	78	W	P	missense	low	0.26090731207984	0.417997779485942	6	0.170646878892827	-0.0735544246242687	0.595369048783948	0.630379201545776	0.849661686461237	0.122720212516184	0.289284181194973	NA	NA	-0.236320303928416	-0.0902811053107165	0.472092672673226	0.607550408356644	0.641034470880345	0.455240943182092	0.488944402164361	NA	NA	0.437119433095043	0.451354001325111	NA	NA	p.Trp78Pro	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	147	-0.9	-1.6	0.7	264	154	110	5.4	8	-2.6	204	115	89	5.89	6.3	0.41	-1.007	-4.568	3.561	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78Q	78	W	Q	missense	possibly_low	0.540617887352898	0.317745474439103	5	0.142100096077751	0.262106816840824	0.819128957864972	0.864373677537884	0.58912282799832	0.721793753109175	0.49917334195981	NA	NA	0.0286258361593013	NA	0.584702903253792	0.657390943895803	0.584702903253792	0.634492734397404	0.558460505010232	NA	NA	0.4916201985585	NA	NA	NA	p.Trp78Gln	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	130	-0.9	-3.5	2.6	264	214	50	5.4	10.5	-5.1	204	146	58	5.89	6.24	0.35	-1.007	-4.402	3.395	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78R	78	W	R	missense	low	0.487296062553898	0.222690949991975	6	0.0909131996359976	0.309109465548043	0.665482659559753	0.707778098686346	0.806547462611904	0.427343303812193	0.429924008931096	NA	NA	0.250380830911843	0.301802670370004	0.542961482022294	0.624036278235711	0.631712668248816	0.546388742342618	0.535524857741502	NA	NA	0.537236326256594	0.53953422170197	NA	NA	p.Trp78Arg	1	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	101	-0.9	-4.5	3.6	264	265	-1	5.4	10.5	-5.1	204	174	30	5.89	6.34	0.45	-1.007	-3.588	2.581	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78S	78	W	S	missense	possibly_wt-like	0.735263104278025	0.138476283069909	6	0.0565327058330805	0.624461036896589	0.84606517165946	0.516002587375845	0.654917806784514	0.799638416281248	0.917612111925072	NA	NA	0.797441060090443	0.725966643211027	0.642349358611568	0.583188330238281	0.598928552045101	0.657785025518014	0.697049046036398	NA	NA	0.649769391410806	0.63492932581233	NA	NA	p.Trp78Ser	1	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	177	-0.9	-0.8	-0.1	264	143	121	5.4	9.2	-3.8	204	105	99	5.89	5.68	-0.21	-1.007	-3.403	2.396	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78T	78	W	T	missense	possibly_low	0.609771940461468	0.169299980339274	6	0.0691164275490744	0.47430623172521	0.745237649197726	0.826257353734519	0.800717498030135	0.45061394049683	0.473082164338702	NA	NA	0.484175228392925	0.623785457775696	0.598638823222166	0.649272213814295	0.630452161290139	0.553351665966841	0.549819005943442	NA	NA	0.585329020188909	0.611948626255424	NA	NA	p.Trp78Thr	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	128	-0.9	-0.7	-0.2	264	163	101	5.4	8.6	-3.2	204	119	85	5.89	5.6	-0.29	-1.007	-3.358	2.351	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78V	78	W	V	missense	wt-like	0.971296468048106	0.0642778066723919	4	0.0321389033361959	0.908305375006548	1.03428756108966	0.896563971668935	1.04425465934638	0.944930258227168	NA	NA	NA	NA	0.999436982949945	0.689770485554559	0.664247436946984	0.683107761891142	0.701258524434356	NA	NA	NA	NA	0.696433209217976	NA	NA	p.Trp78Val	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	88	-0.9	4.2	-5.1	264	165	99	5.4	5.9	-0.5	204	117	87	5.89	5.61	-0.28	-1.007	-3.94	2.933	0.004032037	NA	NA	NA	NA	NA	NA	NA
W78X	78	W	X	nonsense	low	0.255306077899684	0.139870994929674	6	0.057102094565519	0.143388029109467	0.367224126689902	0.235402581958755	0.38665511118339	0.398525778340007	0.235028462386195	NA	NA	0.0120588745135796	0.264165659016177	0.527245238255207	0.523420874263164	0.540926999923129	0.53776610637347	0.470974697988386	NA	NA	0.48821229048029	0.531069602247251	NA	NA	p.Trp78Ter	1	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	NA	-0.9	NA	NA	264	NA	NA	5.4	NA	NA	204	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
W78Y	78	W	Y	missense	wt-like	0.910332952806754	0.0971757319994473	6	0.0396718264633489	0.832577601737667	0.988088303875841	0.994555076118087	0.988362899668712	0.942524646062449	0.944778428536322	NA	NA	0.848877190412721	0.742899476042232	0.678071363639486	0.685119421651376	0.671023305627596	0.700538729183395	0.706046635300225	NA	NA	0.660350064426514	0.638737544930981	NA	NA	p.Trp78Tyr	0	20.9	20.8	29.7	0.92	109.5	40	-59	-44	18.1818181818182	-1.8	1	0	14.12	0	0	0	0	7	18.7418156491426	37	-0.9	-1.3	0.4	264	255	9	5.4	6.2	-0.8	204	181	23	5.89	5.66	-0.23	-1.007	-1.999	0.992	0.004032037	NA	NA	NA	NA	NA	NA	NA
F79A	79	F	A	missense	possibly_wt-like	0.756585211288845	0.114446971852256	6	0.0467227806074493	0.665010244040678	0.848160178537012	0.866241016160121	0.934170166391774	0.6959134851332	0.703473014211856	NA	NA	0.655997967739998	0.683715618096121	0.626437158776947	0.657788684725242	0.659306198868674	0.626748969938647	0.626125347615246	NA	NA	0.620673829572971	0.625427007846451	NA	NA	p.Phe79Ala	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.8	-3.485	1.685	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79C	79	F	C	missense	low	0.505072832441105	0.269668888034445	6	0.110091862531353	0.289296746888719	0.720848917993492	0.762660816914359	0.85103273552523	0.248031003997324	0.42092820492718	NA	NA	0.560973838459578	0.18681039482296	0.566836148303402	0.63572622970457	0.64133090782462	0.492735812024686	0.532545412618949	NA	NA	0.601126883987854	0.513672289053086	NA	NA	p.Phe79Cys	1	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.8	-3.774	1.974	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79D	79	F	D	missense	low	0.103725512975903	0.0947192583019055	3	0.0546861892780469	-0.00345744846080931	0.210908474412615	0.211235809231483	0.0325666283946607	NA	NA	NA	NA	NA	0.0673741013015656	0.486810890196613	0.518273381400892	0.464368902479727	NA	NA	NA	NA	NA	0.486810890196613	NA	NA	p.Phe79Asp	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.8	-4.414	2.614	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79E	79	F	E	missense	low	0.0758969273915963	0.162837101403577	6	0.066477968272101	-0.054397496187118	0.206191350970311	-0.0401752781196298	-0.0405072390604648	-0.0502690587710986	0.0358415750203806	NA	NA	0.209844323894563	0.340647241385827	0.456646300678063	0.464723129067224	0.448569472288901	0.403479957863689	0.405003229537069	NA	NA	0.528897761063966	0.548270423108603	NA	NA	p.Phe79Glu	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.8	-4.252	2.452	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79G	79	F	G	missense	low	0.0645901708588991	0.104631633536746	6	0.042715685519818	-0.0191310343348833	0.148311376052681	0.0534710981222831	0.228210746222937	0.0714522071436329	0.124918684624151	NA	NA	-0.0487666318864513	-0.0417450790731586	0.468985000244046	0.48466969200812	0.50666946339874	0.439900786803345	0.434505913190974	NA	NA	0.47570017515977	0.462269825328321	NA	NA	p.Phe79Gly	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.8	-4.098	2.298	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79H	79	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe79His	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.8	-5.14	3.34	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79I	79	F	I	missense	wt-like	0.839407244853361	0.126849360780325	6	0.0517860346850013	0.737908481968617	0.940906007738106	0.881245919016659	0.984888166892909	0.801341019137495	0.870815441576608	NA	NA	0.609821631846213	0.888331290650284	0.66562836904044	0.660984710575477	0.670272027505403	0.658294469836668	0.681549807595815	NA	NA	0.611175122961598	0.671445374883087	NA	NA	p.Phe79Ile	1	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.8	-2.487	0.687	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79K	79	F	K	missense	low	-0.102509998511301	0.126232353776985	6	0.0515341426306836	-0.203515062041591	-0.00150493498101104	0.0766815654200481	-0.0325008546057439	-0.192175739296886	-0.0453255022018956	NA	NA	-0.273593187914309	-0.148146272469021	0.433896125733911	0.489613492990301	0.450300546839608	0.361019350031656	0.378120379239695	NA	NA	0.429452211720959	0.438340039746863	NA	NA	p.Phe79Lys	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.8	-4.124	2.324	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79L	79	F	L	missense	wt-like	1.00325353082274	0.149878324397516	6	0.0611875697128744	0.883328097883968	1.1231789637615	0.938333768663847	1.14445999917372	1.12265117569311	1.06447031755969	NA	NA	1.011113872194	0.738492051652049	0.699248154429938	0.673144352323989	0.704773335734244	0.754435289278059	0.74568905245433	NA	NA	0.693722973125632	0.637746308674531	NA	NA	p.Phe79Leu	1	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.8	-0.98	-0.82	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79M	79	F	M	missense	wt-like	0.964718240518308	0.0787468291047851	6	0.0321482583614785	0.901708811964122	1.02772766907249	1.07373092416536	1.04437040540901	0.940049941421963	0.899350952096087	NA	NA	0.954338234457969	0.876468985559466	0.687066833368221	0.701983779887663	0.683132787552162	0.699798260427093	0.691000879184281	NA	NA	0.682043936340023	0.668777524943951	NA	NA	p.Phe79Met	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.8	-3.548	1.748	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79N	79	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe79Asn	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.8	-4.49	2.69	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79P	79	F	P	missense	low	0.0412489868757482	0.0849735446406554	6	0.0346903043342023	-0.0267427602320221	0.109240733983518	0.0225076221699295	0.152493237896825	0.0635511172401975	0.0821160985906774	NA	NA	-0.104009561292198	0.0308354066490579	0.47120546698757	0.478074509719837	0.490298446937126	0.437536662164587	0.420329530942698	NA	NA	0.464336424255303	0.478593283790566	NA	NA	p.Phe79Pro	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.8	-4.512	2.712	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79Q	79	F	Q	missense	low	0.0545346608888172	0.0776568270341311	6	0.0317032668795319	-0.00760260038732696	0.116671922164961	-0.0942455908600087	0.0851154214750767	0.093877286436368	0.115227476599335	NA	NA	0.0345844513571819	0.0926489203249499	0.464468394493784	0.453206218967854	0.475730570019713	0.446610706970056	0.431296147563731	NA	NA	0.492845915941207	0.49249523433352	NA	NA	p.Phe79Gln	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.8	-4.557	2.757	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79R	79	F	R	missense	low	-0.0276710579096639	0.107969602714475	6	0.044078405730247	-0.114063145636892	0.0587210298175641	0.032415445982876	0.133679637053671	-0.0343763372725728	-0.00825685716923502	NA	NA	-0.164852152049216	-0.124636084003507	0.447724155230136	0.480184864003934	0.486230725007094	0.408235298573741	0.390397658023684	NA	NA	0.451820794595858	0.443627515864413	NA	NA	p.Phe79Arg	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.8	-4.385	2.585	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79S	79	F	S	missense	low	0.379317108069682	0.150200173086319	6	0.061318963889866	0.259134147276233	0.499500068863132	0.411466106905985	0.358532694865054	0.173212068614875	0.529993408378347	NA	NA	0.551651297988235	0.251047071665597	0.547884395509986	0.56092218849324	0.534846602526731	0.470348864053572	0.568668230359461	NA	NA	0.599209190106434	0.528119212571986	NA	NA	p.Phe79Ser	1	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.8	-3.971	2.171	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79T	79	F	T	missense	low	0.595464904889524	0.111509064558806	6	0.0455233849773572	0.506240709879552	0.684689099899496	0.692291475618348	0.767468762619579	0.582532070816792	0.48304149476539	NA	NA	0.516246388934878	0.531209236582157	0.592374885187218	0.62073764657302	0.6232633933715	0.59282354971958	0.553117574748495	NA	NA	0.591926220654857	0.591128097345932	NA	NA	p.Phe79Thr	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.8	-3.836	2.036	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79V	79	F	V	missense	wt-like	0.836951398534024	0.0856668587577218	6	0.0349733486372491	0.768404894786253	0.905497902281795	0.981227016412942	0.86680095856708	0.769511437796026	0.735683865351219	NA	NA	0.843453041525103	0.825032071551773	0.652989934278729	0.682280561329627	0.644740183231263	0.648770581561709	0.636793706249858	NA	NA	0.659234289475934	0.65720928699575	NA	NA	p.Phe79Val	1	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.8	-2.784	0.984	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79W	79	F	W	missense	possibly_low	0.667377442500607	0.119700375168308	6	0.0488674735303447	0.571598954365668	0.763155930635547	0.814077623856944	0.705042157762467	0.769160801864196	0.600097857877284	NA	NA	0.487717816897107	0.628168396745646	0.611350191186309	0.646677946333207	0.609766026667926	0.648665666030332	0.591887095514588	NA	NA	0.586057748620793	0.612934355704691	NA	NA	p.Phe79Trp	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.8	-5.271	3.471	0.003269986	NA	NA	NA	NA	NA	NA	NA
F79X	79	F	X	nonsense	low	-0.23894672387358	0.126438115006796	6	0.0516181443009977	-0.340116427652327	-0.137777020094833	-0.337507106081468	-0.134807958546311	-0.145917560117065	-0.0953141554388728	NA	NA	-0.379419772128157	-0.340713790929606	0.398211567918643	0.401391815472646	0.428180546858396	0.374860491251371	0.361563943705409	NA	NA	0.407683146339866	0.395031320364639	NA	NA	p.Phe79Ter	0	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F79Y	79	F	Y	missense	possibly_wt-like	0.742075914978824	0.199631177518711	6	0.0814990869453016	0.582340639793134	0.901811190164513	0.805031417813381	1.08704733994603	0.49093807771666	0.632366069747919	NA	NA	0.724847579505017	0.71222500514393	0.63333767759761	0.644751115574074	0.692360043087669	0.565417252803996	0.602574452245528	NA	NA	0.634836544084732	0.631838811110487	NA	NA	p.Phe79Tyr	1	20.9	23.7	27.3	0.896	115.1	50	-72.7	-43.6	0	-4.4	1	0	12.91	0	0	0	0	8	18.6769575877748	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.8	-4.005	2.205	0.003269986	NA	NA	NA	NA	NA	NA	NA
A80A	80	A	A	synonymous	possibly_wt-like	0.772867872885369	0.78727626370638	8	0.278344192366995	0.22732328054017	1.31841246523057	1.17945784548121	1.46377606590147	1.19533821299006	1.43258765721177	-0.73991018915088	-0.104855862825088	0.902032782741089	0.854516470733329	0.697893961785314	0.724503484068483	0.773813227569339	0.776184341357235	0.867610940889885	0.39780058106455	0.459866360828069	0.671284439502145	0.663840371929053	NA	NA	p.Ala80=	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80C	80	A	C	missense	wt-like	1.03987263139845	0.181192488376777	6	0.0739715236247126	0.894891109212458	1.18485415358444	1.35176441891474	1.11274485555696	0.95885763291004	0.838975089434771	NA	NA	0.920057290826007	1.05683650074818	0.701670976151142	0.761204572247737	0.697916148411118	0.705425803891166	0.671004159663949	NA	NA	0.674992172279097	0.709342445567239	NA	NA	p.Ala80Cys	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.564	-3.722	2.158	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80D	80	A	D	missense	possibly_low	0.614198157966908	0.216748570038341	6	0.0884872331786396	0.440766367845177	0.787629948088639	0.90969277556416	0.810651603658548	0.469822296986598	0.656973334582845	NA	NA	0.347859011187517	0.49018992582178	0.596313633704525	0.667043856026333	0.632600031847022	0.559099094410576	0.610724473651049	NA	NA	0.557288082584315	0.581902793758001	NA	NA	p.Ala80Asp	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.564	-4.26	2.696	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80E	80	A	E	missense	possibly_low	0.420526126462547	0.386835799240255	6	0.157925053730056	0.110998708895084	0.730053544030009	0.895597196532616	0.831152067162941	0.299968246358982	0.221680757782635	NA	NA	-0.126709279028345	0.401467769966451	0.535112631993897	0.664041515032222	0.637032473338039	0.508276214151102	0.466553886534397	NA	NA	0.459666977129125	0.561949049836692	NA	NA	p.Ala80Glu	1	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.564	-3.448	1.884	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80F	80	A	F	missense	low	0.607218536369136	0.138008217882978	6	0.0563416190206902	0.496790992257906	0.717646080480366	0.621677797882323	0.58717195470391	0.599680549579153	0.849249955185392	NA	NA	0.562713219389276	0.422817741474763	0.599719657657236	0.605697020080317	0.584281101486627	0.597954631843034	0.674407234990207	NA	NA	0.601484683471439	0.566750689969274	NA	NA	p.Ala80Phe	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.564	-4.442	2.878	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80G	80	A	G	missense	low	0.448929370595359	0.297807175170119	6	0.121579270151073	0.21063837983259	0.687220361358128	0.736180672218969	0.89770615616932	0.389932850716076	0.222534385604459	NA	NA	0.183239609884952	0.263982548978379	0.533111697019187	0.630085991458872	0.651422250693343	0.535194973509133	0.466836611374678	NA	NA	0.523425036388755	0.531028420529241	NA	NA	p.Ala80Gly	1	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.564	-3.461	1.897	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80H	80	A	H	missense	low	0.525065380679582	0.230839836573074	6	0.094239968651915	0.340358436217644	0.709772325141519	0.87328066923157	0.763320499161522	0.375604750505731	0.392205030762143	NA	NA	0.340036361159483	0.40594497325704	0.559317451624541	0.659288122169666	0.622366489988646	0.530907790962438	0.523032186104343	NA	NA	0.555678923778154	0.562955979470928	NA	NA	p.Ala80His	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.564	-3.351	1.787	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80I	80	A	I	missense	low	0.370757949917019	0.325383781408147	6	0.132837372504543	0.110401484007183	0.631114415826855	0.591870020052821	0.768572335284069	0.623304039974298	0.127983075493283	NA	NA	0.0870411657964095	0.0257770629012327	0.551492264179584	0.599348000070525	0.623501998770124	0.605023134591287	0.435520851313754	NA	NA	0.503636528288643	0.477455654808977	NA	NA	p.Ala80Ile	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.564	-3.05	1.486	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80K	80	A	K	missense	low	0.313413504386287	0.373262730686827	6	0.152383871696771	0.0147466040358441	0.61208040473673	0.710104226623827	0.868894287092003	0.0834129052144385	0.0277357887474475	NA	NA	0.0736295442751513	0.116704274364854	0.499391504339837	0.624531740624919	0.6451927854959	0.443479607111875	0.402318561733631	NA	NA	0.500877689685549	0.497905318994125	NA	NA	p.Ala80Lys	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.564	-3.165	1.601	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80L	80	A	L	missense	wt-like	0.854602006276121	0.0961731374821828	6	0.0392625189656472	0.777648883161131	0.93155512939111	0.737633073264276	0.748149937447777	0.842136471969129	0.931538006086366	NA	NA	0.969611859744051	0.898542689145126	0.672121507432949	0.630395351094859	0.619086435995348	0.670501081375999	0.701661356110962	NA	NA	0.685185798566126	0.6737419334899	NA	NA	p.Ala80Leu	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.564	-2.099	0.535	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80M	80	A	M	missense	wt-like	0.890460931368733	0.110219068099853	6	0.0449967461282851	0.802268929535802	0.978652933201664	0.920695491369159	0.739751650834144	0.774045934708013	0.959551285322207	NA	NA	1.02288667504523	0.925834550933647	0.674633667241165	0.669387420957861	0.61727062758537	0.650127371068602	0.710939462675934	NA	NA	0.69614469841225	0.679879913524468	NA	NA	p.Ala80Met	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.564	-3.659	2.095	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80N	80	A	N	missense	wt-like	1.13601602215673	0.15255010959866	6	0.062278321453728	1.01395275508981	1.25807928922364	1.13307531643802	0.923019376836384	1.0705148473016	1.06689424214504	NA	NA	1.29601591648649	1.32657643373282	0.74266359164417	0.714624062439526	0.656895266926949	0.738835317624635	0.746491865663704	NA	NA	0.752328769348607	0.770007354982909	NA	NA	p.Ala80Asn	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.564	-4.321	2.757	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80P	80	A	P	missense	low	0.318027085705671	0.109488051787816	6	0.0446983099685946	0.230420007997418	0.405634163413924	0.2570374508576	0.48680239901485	0.360977205353806	0.354351551202059	NA	NA	0.165026899259981	0.28396700854573	0.527280042360628	0.52802907472459	0.562580022241474	0.526531009996665	0.510494967085581	NA	NA	0.519678589394295	0.535522955009026	rs1800462	*2	p.Ala80Pro	1	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.564	-4.406	2.842	0.007776647	0.225239617	0.0050000001330312	0.2	0.08	0.00166	12.14833333	0.561728225
A80Q	80	A	Q	missense	low	0.504587279592812	0.210558890474888	6	0.0859603070783409	0.33610817361926	0.673066385566364	0.559332597348801	0.896939976219513	0.438193687434262	0.42090442296645	NA	NA	0.423957674728937	0.28819531885891	0.561288651870647	0.592417569060321	0.651256593570597	0.549635339910095	0.532537535941459	NA	NA	0.572941963831199	0.536473908244953	NA	NA	p.Ala80Gln	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.564	-3.492	1.928	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80R	80	A	R	missense	low	0.419184962919989	0.182694162832891	6	0.0745845796542542	0.273001872995592	0.565368052844386	0.526052120177073	0.720749579424368	0.396865566064557	0.368042414025915	NA	NA	0.20018369318179	0.303216404646232	0.538560759290891	0.585328868362558	0.613162156100619	0.537269345952574	0.51502943387102	NA	NA	0.526910520304272	0.539852172629207	NA	NA	p.Ala80Arg	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.564	-2.614	1.05	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80S	80	A	S	missense	wt-like	0.974994537777674	0.114279182782366	6	0.0466542810065083	0.883553827280307	1.06643524827504	0.992753450813161	1.13791308565317	1.01037843249569	1.02180688417612	NA	NA	0.828622519148311	0.858492854379592	0.694046746827258	0.684735677677687	0.70335781597683	0.720841600091131	0.731558758102576	NA	NA	0.656183575766761	0.664734666485418	NA	NA	p.Ala80Ser	1	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.564	-2.685	1.121	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80T	80	A	T	missense	possibly_wt-like	0.779044159677337	0.148821450430651	6	0.0607561027226658	0.659964386499896	0.898123932854778	0.895755325825978	1.00617049392349	0.730933432112942	0.776892657072577	NA	NA	0.639962425396958	0.624550623732074	0.643834840563714	0.664075196377186	0.674873517092969	0.637227463477471	0.650442217649957	NA	NA	0.617375237141966	0.612120713209395	NA	NA	p.Ala80Thr	1	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.564	-3.122	1.558	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80V	80	A	V	missense	wt-like	0.979242217530116	0.209617324646112	6	0.0855759144383839	0.811516507286802	1.14696792777343	0.82984757607048	1.33204873770485	1.05826136264072	0.815742498288615	NA	NA	1.04795106210303	0.791602068373	0.682305002762408	0.650036926755361	0.74533222884097	0.735168891175692	0.663309435507604	NA	NA	0.701300570017212	0.649690829894623	NA	NA	p.Ala80Val	1	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.564	-2.548	0.984	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80W	80	A	W	missense	low	0.306895914319891	0.114554887328056	6	0.0467668369159593	0.215234598293753	0.39855723034603	0.477651884364822	0.163334283098981	0.394204364659269	0.307834655756914	NA	NA	0.221250719221646	0.277099578817717	0.532611287190745	0.575019677673862	0.492642408504129	0.536473074566243	0.495088391176411	NA	NA	0.531244114463563	0.533978459917926	NA	NA	p.Ala80Trp	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.564	-4.031	2.467	0.007776647	NA	NA	NA	NA	NA	NA	NA
A80X	80	A	X	nonsense	low	-0.0771102178570758	0.152009535147735	6	0.0620576328582691	-0.198740943225093	0.0445205075109412	0.142462341512013	0.0640174350576532	-0.158696789593893	-0.251562149978733	NA	NA	-0.0802552574478587	-0.178626886691636	0.450353854837231	0.50362471737799	0.471168937042318	0.371036754065773	0.309814002839888	NA	NA	0.469222805095346	0.431484904579116	NA	NA	p.Ala80Ter	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A80Y	80	A	Y	missense	possibly_low	0.614509191210165	0.173367330320892	6	0.070776916225788	0.475788984470812	0.753229397949518	0.673163999098324	0.751570642996509	0.510228774747748	0.45321907847127	NA	NA	0.438810813691314	0.860061838255828	0.59633042374531	0.616663517603827	0.619826032795172	0.571189318773045	0.543240274983896	NA	NA	0.575997329886793	0.665087533277047	NA	NA	p.Ala80Tyr	0	17.2	24.6	27.7	0.877	107.6	55.4	-59.6	-40.9	7.43801652892562	-3.9	1	0	14.6	0	0	0	0	10	19.7756438628451	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.564	-3.217	1.653	0.007776647	NA	NA	NA	NA	NA	NA	NA
D81A	81	D	A	missense	wt-like	0.847832256813184	0.0736780748605368	6	0.0300789481064827	0.788878601831629	0.906785911794739	0.845710279680085	0.938546375643862	0.81712142541959	0.931628595441473	NA	NA	0.755692261044586	0.798294603649507	0.656834024962899	0.653415663110779	0.660252386815018	0.663016204148904	0.701691359656182	NA	NA	0.641181451596223	0.651195990965207	NA	NA	p.Asp81Ala	1	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.942	-2.232	0.29	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81C	81	D	C	missense	possibly_low	0.697328226082139	0.232104401974664	6	0.0947562253152938	0.511609437153201	0.883047015011077	0.913465868290642	0.887457066137023	0.919214386186467	0.519915575204623	NA	NA	0.517815749777645	0.426100710896432	0.62072766147246	0.667847520135622	0.649206276801114	0.693563949705857	0.565330412985686	NA	NA	0.592249046143807	0.567489034642145	NA	NA	p.Asp81Cys	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.942	-5.536	3.594	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81E	81	D	E	missense	wt-like	1.0248724948529	0.086546280753503	6	0.0353323711636231	0.955622319883797	1.094122669822	0.964356971722048	1.13686011775299	1.04775384980865	1.1122270527924	NA	NA	0.94095079709673	0.947086179944592	0.693894794103978	0.67868726256307	0.703130151923845	0.732024885692654	0.76150626810245	NA	NA	0.679290072541365	0.68465943628411	NA	NA	p.Asp81Glu	1	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.942	-2.068	0.126	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81F	81	D	F	missense	low	0.253854889175059	0.206592124266559	6	0.0843408815551207	0.0885497989026645	0.419159979447455	-0.0749260698579828	0.135786722162323	0.444450402573202	0.190619259675965	NA	NA	0.412495999709854	0.414703020786997	0.519096872277944	0.457321253175472	0.486686301607043	0.551507442948845	0.456266198075109	NA	NA	0.570584239118446	0.5649256772987	NA	NA	p.Asp81Phe	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.942	-4.823	2.881	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81G	81	D	G	missense	possibly_low	0.621824990781445	0.13867158444764	6	0.0566124372866641	0.510866652622551	0.732783328940339	0.661834114029868	0.804442670905693	0.745605896059342	0.488172486372596	NA	NA	0.463572530989051	0.56732224633212	0.60675011630509	0.614250266021648	0.631257587509468	0.641617684820465	0.554816979038683	NA	NA	0.581090940786237	0.599249966588531	NA	NA	p.Asp81Gly	1	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.942	-2.271	0.329	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81H	81	D	H	missense	possibly_low	0.650906618882408	0.295905931462297	6	0.1208030906576	0.414136911972385	0.88767632579243	0.922086298783981	0.982422762316224	0.819900457482946	0.490850075486041	NA	NA	0.264047852066358	0.426132267158896	0.615671931964064	0.669683661226323	0.669738978019204	0.663847732235937	0.555703806922081	NA	NA	0.540047701860254	0.567496131692192	NA	NA	p.Asp81His	1	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.942	-3.76	1.818	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81I	81	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp81Ile	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.942	-4.515	2.573	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81K	81	D	K	missense	possibly_low	0.704893026560163	0.131202378526094	6	0.0535631467380707	0.59991118805491	0.809874865065416	0.770825994277198	0.879735810467686	0.795974428470195	0.654550995965011	NA	NA	0.58281220594466	0.545458724236228	0.623693794079381	0.637465402438502	0.647536850449647	0.656688705394324	0.609922185720261	NA	NA	0.605619146996537	0.594332828170134	NA	NA	p.Asp81Lys	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.942	-3.182	1.24	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81L	81	D	L	missense	possibly_low	0.642571676951791	0.166937989112854	6	0.0681521486687975	0.508995920091929	0.776147433811654	0.781107853457762	0.811330840077169	0.58079945775269	0.569882262126162	NA	NA	0.372260519293474	0.740049129003491	0.612526008325767	0.639655425795783	0.632746890755039	0.592305125896495	0.581879573191233	NA	NA	0.562307596625158	0.638096497671144	NA	NA	p.Asp81Leu	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.942	-4.075	2.133	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81M	81	D	M	missense	possibly_low	0.64878012950721	0.174454215506791	6	0.0712206352448616	0.509190249471217	0.788370009543202	0.444964932866805	0.954655053145005	0.707195069714707	0.651512033346866	NA	NA	0.580086187391203	0.554267500578672	0.606987030339906	0.568057397214478	0.663735272482759	0.630124589302474	0.608915669532679	NA	NA	0.605058391147134	0.596313934982775	NA	NA	p.Asp81Met	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.942	-4.311	2.369	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81N	81	D	N	missense	wt-like	0.862614214315555	0.117524738532387	6	0.0479792735930594	0.768576566068765	0.956651862562345	0.658878163271439	0.841807933976757	0.902211766113683	0.930329295585608	NA	NA	1.00517649230682	0.837281634639023	0.674220371260507	0.613620652146352	0.639336397158015	0.688476510690635	0.701261026512351	NA	NA	0.692501623954093	0.65996423183038	NA	NA	p.Asp81Asn	1	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.942	-2.932	0.99	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81P	81	D	P	missense	low	-0.0278628275311142	0.191271399581549	6	0.0780862218937979	-0.180909010131761	0.125183355069533	-0.326666716745341	-0.169198845012371	0.021142092667157	0.0266604069240754	NA	NA	0.216719212318837	0.0641668846609574	0.422796039095418	0.403700805065989	0.420744832438945	0.424847245751892	0.40196239110929	NA	NA	0.530311960498896	0.486089582436112	NA	NA	p.Asp81Pro	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.942	-3.818	1.876	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81Q	81	D	Q	missense	wt-like	0.897379306911491	0.11135926992223	6	0.0454622315730542	0.808274970371485	0.986483643451497	1.03757676880951	1.0268838505533	0.854421809096662	0.887837831400812	NA	NA	0.783643841712167	0.793911739896497	0.676764513572102	0.694282989271725	0.679351988583359	0.674177038560845	0.687187689025184	NA	NA	0.646931233577544	0.650210278432341	NA	NA	p.Asp81Gln	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.942	-2.547	0.605	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81R	81	D	R	missense	possibly_low	0.710921145915931	0.132361380212733	6	0.0540363071952857	0.605011929955628	0.816830361876234	0.787106241343963	0.921675925289769	0.732018215617538	0.666271821841131	NA	NA	0.568029986083632	0.590424685319553	0.625678107808297	0.640933075036656	0.656604796890741	0.637552046976998	0.613804168639597	NA	NA	0.602578369359964	0.604445739246091	NA	NA	p.Asp81Arg	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.942	-3.215	1.273	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81S	81	D	S	missense	wt-like	0.981025364385027	0.0614969354836926	6	0.025106018779984	0.931818471781072	1.03023225698898	0.983381339982003	1.02745128406084	0.926911302669329	1.05133253185461	NA	NA	0.890373682976166	1.00670204476721	0.689303206096841	0.682739429599707	0.679474674386131	0.695866982593976	0.741337766952434	NA	NA	0.668886103517356	0.698067132353372	NA	NA	p.Asp81Ser	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.942	-2.276	0.334	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81T	81	D	T	missense	wt-like	0.93879763033276	0.18055444499269	6	0.0737110435039171	0.794326639802217	1.0832686208633	0.823082337361201	0.936757921334987	0.645608524409016	1.14239468155794	NA	NA	1.02379849765616	1.06114381967725	0.678098983447207	0.64859593923251	0.659865701944125	0.611696970967202	0.771497903574427	NA	NA	0.696332264950289	0.710311167957599	NA	NA	p.Asp81Thr	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.942	-2.788	0.846	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81V	81	D	V	missense	possibly_low	0.578414813873156	0.228396135392618	6	0.0932423318225891	0.395663201666348	0.761166426079963	0.766732157062767	0.94632085089711	0.517884459036999	0.46704520745995	NA	NA	0.392823538751063	0.379682670031045	0.570008764221584	0.636593420147842	0.661933319866898	0.573480014370231	0.547819542446946	NA	NA	0.566537514072936	0.557049548678041	NA	NA	p.Asp81Val	1	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.942	-4.121	2.179	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81W	81	D	W	missense	low	0.516012968768366	0.115768053964789	6	0.0472621101214536	0.423380935096951	0.608645002439781	0.57716032088769	0.604611794128092	0.456881488982118	0.619156929329738	NA	NA	0.52523746554171	0.313029813740848	0.590913765383338	0.596214852243417	0.588051800029314	0.555227010505351	0.598199533786329	NA	NA	0.593775730737362	0.542059222831958	NA	NA	p.Asp81Trp	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.942	-5.915	3.973	0.008679484	NA	NA	NA	NA	NA	NA	NA
D81X	81	D	X	nonsense	low	0.109405377285198	0.150067406593596	6	0.061264762196181	-0.0106713501407276	0.229482104711124	-0.0672116559673099	0.0196445166523758	0.132425840729725	0.363830832236266	NA	NA	0.1672237115716	0.0405190184885325	0.471173066116202	0.458964413844336	0.461574989833518	0.45814501275663	0.513634541672842	NA	NA	0.520130484834338	0.480771142398886	NA	NA	p.Asp81Ter	0	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D81Y	81	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp81Tyr	1	17.6	24.5	31.6	0.738	105.2	54.4	-64.2	-24.4	55.0802139037433	-3.5	1	0	17.02	0	0	1	4	7	22.5497365275697	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.942	-4.783	2.841	0.008679484	NA	NA	NA	NA	NA	NA	NA
R82A	82	R	A	missense	wt-like	0.992259770287237	0.0805032207238247	6	0.0328653022373365	0.927844961561033	1.05667457901344	0.94657959511955	0.92020542263229	1.06926042976694	1.11715206854078	NA	NA	0.955510961284987	0.94485014437888	0.683220860390664	0.674900703215491	0.65628685690903	0.7384599770783	0.763137452390549	NA	NA	0.682285172199246	0.684156548582081	NA	NA	p.Arg82Ala	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.241	-3.15	0.909	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82C	82	R	C	missense	possibly_wt-like	0.846055016085408	0.274601948993902	6	0.112105776234806	0.626331732206282	1.06577829996453	1.26898462226208	1.03280982020559	0.470610471127455	0.816247054848895	NA	NA	0.760286263101301	0.72739186496713	0.652801503862725	0.743572577391882	0.68063325296822	0.559334927938457	0.663476546594275	NA	NA	0.642126461131175	0.635249860290761	NA	NA	p.Arg82Cys	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.241	-3.832	1.591	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82D	82	R	D	missense	wt-like	0.855740360482899	0.0643533879055619	6	0.0262721605980035	0.804247871914759	0.907232849051038	0.754274532503204	0.944386362778145	0.864656427142928	0.890231470112747	NA	NA	0.860651125377462	0.820242244982906	0.662143541681069	0.633939961441341	0.66151506076751	0.677239389829743	0.687980471435997	NA	NA	0.662772022594627	0.65613204792439	NA	NA	p.Arg82Asp	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.241	-4.04	1.799	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82E	82	R	E	missense	wt-like	0.949655237350711	0.12571598115215	6	0.0513233343893525	0.849063350381074	1.05024712432035	0.786502491815045	0.842618597142444	0.976935191340901	0.917333191596206	NA	NA	1.06195511916507	1.1125868330446	0.700568971080331	0.640804477129696	0.639511672075583	0.71083488059037	0.696956666543353	NA	NA	0.70418127561731	0.721880777660798	NA	NA	p.Arg82Glu	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.241	-2.601	0.36	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82F	82	R	F	missense	possibly_low	0.707525091257343	0.403238281779003	6	0.164621339185864	0.384873195366298	1.03017698714839	1.0394312482634	1.35277077169489	0.529083608624837	0.279281074690169	NA	NA	0.55865756486972	0.485926279401042	0.590797154067982	0.694677991114123	0.749812576478772	0.576830967947184	0.485631334552712	NA	NA	0.600650414756681	0.580943893379282	NA	NA	p.Arg82Phe	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.241	-3.988	1.747	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82G	82	R	G	missense	possibly_wt-like	0.771192692281517	0.145779388679175	6	0.0595141862131404	0.654547030734552	0.887838353828483	0.897236057940982	1.00719575230474	0.648700072531801	0.709638973930717	NA	NA	0.677807518749484	0.686577778231377	0.627119124620549	0.664390590496166	0.675095190021832	0.612622008547878	0.628167537351952	NA	NA	0.625160164886397	0.626070711889146	NA	NA	p.Arg82Gly	1	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.241	-3.961	1.72	0.007543469	NA	NA	NA	NA	4.06e-06	NA	NA
R82H	82	R	H	missense	wt-like	1.01953764115061	0.186700330388637	6	0.0762200907101995	0.870149008460244	1.16892627384098	0.667236073805217	0.99686030151859	1.10384505645742	1.07662454605466	NA	NA	1.21381179103796	1.05884807802982	0.722606907937676	0.615400876808603	0.672860543918192	0.748808216255491	0.749714579999392	NA	NA	0.735418963605765	0.709794852269588	NA	NA	p.Arg82His	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.241	-2.976	0.735	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82I	82	R	I	missense	wt-like	1.0481857154095	0.263295334589834	5	0.117749253260284	0.817401419812859	1.27897001100614	1.00656635841596	0.74779690169405	0.859588143464388	1.38054025104405	NA	NA	1.24643692242906	NA	0.687677810005203	0.687677810005203	0.619010105510318	0.675722883313921	0.850372638412369	NA	NA	0.742130118686463	NA	NA	NA	p.Arg82Ile	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.241	-3.794	1.553	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82K	82	R	K	missense	wt-like	0.898137143236844	0.176383179402709	6	0.072008131457737	0.757003798985654	1.03927048748803	0.89201073120783	1.15831547348962	1.03018702453669	0.66005567416446	NA	NA	0.861207075389442	0.787046880633018	0.663081993331565	0.663277602329915	0.707769052354132	0.726768628017099	0.61174535645691	NA	NA	0.662886384333214	0.648666361442512	NA	NA	p.Arg82Lys	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.241	-2.181	-0.06	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82L	82	R	L	missense	wt-like	1.14316281792456	0.239002210557243	6	0.0975722438770789	0.951924734034732	1.3344009018144	0.765214832411342	1.00099492652547	1.07605532735259	1.29389903140687	NA	NA	1.36726109421957	1.35555169563155	0.753738688157765	0.636270231863618	0.673754498507383	0.740493112379431	0.821676730948439	NA	NA	0.7669842639361	0.776523934189155	NA	NA	p.Arg82Leu	1	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.241	-2.476	0.235	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82M	82	R	M	missense	possibly_wt-like	0.737378235790753	0.318265678699108	6	0.129931419242232	0.482717333615804	0.992039137965702	1.04485214125288	1.21743051272038	0.42819803530035	0.502583564609576	NA	NA	0.639004135896513	0.592201024964813	0.611011676392732	0.695832634652398	0.720550419593629	0.546644490827368	0.559589983958	NA	NA	0.617178112128964	0.604845240656501	NA	NA	p.Arg82Met	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.241	-3.006	0.765	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82N	82	R	N	missense	possibly_wt-like	0.762025388627443	0.211396491157474	6	0.086302256125098	0.5928760748377	0.931174702417187	0.453471250118989	0.649434143334532	0.946371157564978	1.0443737255271	NA	NA	0.719019263642517	0.75948279157654	0.638052393514862	0.569869232325189	0.597742919466927	0.701689663133968	0.739032983348629	NA	NA	0.633637629936506	0.642467157093218	NA	NA	p.Arg82Asn	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.241	-2.808	0.567	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82P	82	R	P	missense	low	-0.00991559064138956	0.362692226938825	6	0.148068481612307	-0.300124481847042	0.280293300564263	0.0317462594384297	0.468418751156544	0.0652837691414283	0.23193320433731	NA	NA	-0.348683758891972	-0.508191769030078	0.454002317072231	0.480042328093163	0.558605261207122	0.438055097608323	0.469949536536138	NA	NA	0.414005700229922	0.35736527567424	NA	NA	p.Arg82Pro	1	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.241	-4.404	2.163	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82Q	82	R	Q	missense	wt-like	1.14897060726977	0.196539566680461	6	0.0802369421058067	0.991709090512765	1.30623212402678	0.846472582914104	0.965951202853091	1.24098446770217	1.23564986712289	NA	NA	1.35281799960636	1.25194752342001	0.758618224443982	0.653578032761882	0.666177633000322	0.789842385595539	0.802384382166369	NA	NA	0.764013246083867	0.753223202804097	NA	NA	p.Arg82Gln	1	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.241	-1.867	-0.374	0.007543469	1.073482428	0.00577350269189626	NA	NA	1.22e-05	NA	NA
R82R	82	R	R	synonymous	wt-like	1.00867132528326	0.0871466400460014	6	0.0355774668184497	0.938940771657925	1.07840187890859	1.1048220622454	1.11262880250449	0.983070915504661	1.01915324644872	NA	NA	0.920904682699105	0.911448242297148	0.703248605213691	0.7086061540521	0.697891056375282	0.712670781314125	0.730679863010988	NA	NA	0.675166485087414	0.676644411459193	NA	NA	p.Arg82=	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82S	82	R	S	missense	wt-like	0.962256052364389	0.088307282158721	6	0.0360512969768078	0.891596808693888	1.03291529603489	0.914888732995684	1.13395693668622	0.938058935940604	0.950053740620843	NA	NA	0.88178267815331	0.954795289789679	0.692797874096537	0.668150588567466	0.702502450008055	0.699202521716117	0.707793839091384	NA	NA	0.667118890230947	0.686393226476956	NA	NA	p.Arg82Ser	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.241	-3.257	1.016	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82T	82	R	T	missense	wt-like	0.800217252913226	0.073467495537781	6	0.0299929794579606	0.741432093386573	0.859002412439878	0.66979433875283	0.804487060278334	0.851646068418014	0.856470342643971	NA	NA	0.854057062563639	0.764848644822565	0.652544767914015	0.615945784095408	0.631267185014276	0.673346495305497	0.676798655277603	NA	NA	0.661415590412794	0.643673945415236	NA	NA	p.Arg82Thr	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.241	-3.607	1.366	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82V	82	R	V	missense	possibly_wt-like	0.77920342757516	0.0850899997825401	6	0.0347378469467925	0.711118498658983	0.847288356491338	0.881333855181905	0.839573863445451	0.845024281207632	0.708077618557238	NA	NA	0.686825337410157	0.71438560964858	0.635589049535288	0.6610034408705	0.638853364815127	0.671365157225814	0.627650410405872	NA	NA	0.627015175945077	0.632324734255449	NA	NA	p.Arg82Val	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.241	-3.596	1.355	0.007543469	NA	NA	NA	NA	NA	NA	NA
R82W	82	R	W	missense	wt-like	0.885008425751483	0.123681141257609	6	0.0504926144810384	0.786044719883382	0.983972131619584	1.06880123013693	0.958374711753126	0.878137262524569	0.901551770390127	NA	NA	0.778072571833522	0.725113007870625	0.672906282240393	0.700933761123846	0.664539506452568	0.681273058028218	0.691729798725986	NA	NA	0.645785195092555	0.634737341963197	rs111901354	*34	p.Arg82Trp	1	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.241	-4.407	2.166	0.007543469	NA	NA	NA	NA	7.72e-05	NA	NA
R82X	82	R	X	nonsense	low	0.215212646633215	0.195652799576884	6	0.0798749209517318	0.0586606782998368	0.371764614966593	0.0420133847166421	0.148263728624045	0.0741415384289272	0.196644419373455	NA	NA	0.246644119830969	0.58356868882525	0.485806595200135	0.482229213147369	0.489383977252902	0.440705475071805	0.458261754299486	NA	NA	0.536467665825625	0.602903815506143	NA	NA	p.Arg82Ter	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R82Y	82	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg82Tyr	0	20.4	27.1	31.2	0.275	127.1	-97.1	-95.9	9.1	47.1698113207547	-1.7	0	0	17.43	1	4	0	0	6	23.8261429986073	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.241	-3.934	1.693	0.007543469	NA	NA	NA	NA	NA	NA	NA
G83A	83	G	A	missense	low	0.439774748551143	0.175933493837643	6	0.0718245480945522	0.299001221079955	0.58054827602233	0.610833880389722	0.6801921500452	0.35971304005225	0.435907409334216	NA	NA	0.214224365352755	0.337777646132712	0.542565815011394	0.603387278993985	0.604393162525878	0.526152752772232	0.53750658312587	NA	NA	0.529798757818077	0.547625046896918	NA	NA	p.Gly83Ala	1	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.004	-2.432	1.428	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83C	83	G	C	missense	possibly_low	0.552151302255979	0.327700248724618	6	0.133783066326408	0.289941310514886	0.814361293997072	0.779700658480944	1.07641583562525	0.542260689717722	0.42271420026512	NA	NA	0.191668885392799	0.300147544054045	0.559967864826821	0.639355694996775	0.690061386725421	0.580773748305254	0.533136941191183	NA	NA	0.525158981134385	0.539161981348389	NA	NA	p.Gly83Cys	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.004	-3.658	2.654	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83D	83	G	D	missense	possibly_low	0.452328075740529	0.387092093868166	5	0.17311284708839	0.113033130186096	0.791623021294963	1.04076555884623	NA	0.538322004257881	0.447956176800879	NA	NA	0.0143455620140933	0.220251076783558	0.541497181569956	0.694962197626872	NA	0.579595234523771	0.541497181569956	NA	NA	0.488682673702753	0.521193147828021	NA	NA	p.Gly83Asp	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.004	-2.995	1.991	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83E	83	G	E	missense	low	0.492126137274332	0.186814177437917	6	0.0762665685734426	0.342646409645931	0.641605864902734	0.775233499684358	0.602605179005268	0.411888554974676	0.310890076289305	NA	NA	0.556704394177347	0.295435119515039	0.564691197923205	0.638404195668356	0.587617946222789	0.541764449623621	0.496100358288925	NA	NA	0.600248637634055	0.538102150107891	NA	NA	p.Gly83Glu	1	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.004	-3.338	2.334	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83F	83	G	F	missense	possibly_low	0.603473838577945	0.225361339661764	6	0.0920033816535611	0.423150524081072	0.783797153074818	0.983187459917298	0.376690049707646	0.599771374419984	0.440993687334302	NA	NA	0.736243045989053	0.483957414099386	0.589241450331191	0.682698133384425	0.538772436347717	0.597981807998051	0.539191178096226	NA	NA	0.637180649365857	0.580501092664331	NA	NA	p.Gly83Phe	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.004	-4.603	3.599	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83G	83	G	G	synonymous	wt-like	1.06679469391741	0.116776518076336	6	0.0476738138709865	0.973355735724609	1.16023365211021	1.04119066058504	1.10293083921483	1.18747194432001	1.17186248121354	NA	NA	0.868948202503585	1.02836403566745	0.699366594339736	0.695052743774301	0.695794242571327	0.773830635753927	0.781257752935088	NA	NA	0.664478773462307	0.702938946108144	NA	NA	p.Gly83=	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83H	83	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly83His	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.004	-2.809	1.805	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83I	83	G	I	missense	low	0.282171255335464	0.302032885883384	6	0.123304409325759	0.0404990539219927	0.523843456748936	-0.116057764003228	-0.0696625726309446	0.429917369619619	0.600608531341169	NA	NA	0.495598536384207	0.352623431301964	0.549061413681987	0.448560252920487	0.442265746025612	0.547158941450778	0.592056232543421	NA	NA	0.587678852609353	0.550963885913195	NA	NA	p.Gly83Ile	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.004	-4.449	3.445	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83K	83	G	K	missense	low	0.43690196550622	0.296710096232329	6	0.121131389550216	0.199488804590504	0.674315126421936	0.814291427472444	0.793608679103502	0.299865670888869	0.308807489329223	NA	NA	0.0897904386631642	0.315048087580119	0.52537932881576	0.646723486240299	0.628915150970554	0.50824552203151	0.49541059742288	NA	NA	0.504202067668294	0.54251313560001	NA	NA	p.Gly83Lys	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.004	-3.386	2.382	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83L	83	G	L	missense	low	0.267154434321889	0.244958794349437	6	0.100004009027247	0.0711501783188672	0.463158690324911	0.705404389704703	0.394850386811748	0.084656314684561	0.106342371304766	NA	NA	0.0937666167602682	0.217906526665289	0.512842921361235	0.623530681142627	0.542698914968741	0.443851653880145	0.428353366282397	NA	NA	0.505019987679657	0.520665855042813	NA	NA	p.Gly83Leu	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.004	-4.003	2.999	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83M	83	G	M	missense	possibly_low	0.524017564132962	0.3281777847864	6	0.133978019607266	0.26142547098272	0.786609657283204	0.992601005785213	0.896506595291038	0.336624115798486	0.326882321284242	NA	NA	0.264201646231183	0.32728970040761	0.542672815254925	0.684703207074264	0.651162891513159	0.519244200233549	0.501397051761581	NA	NA	0.540079338100374	0.545266292409476	NA	NA	p.Gly83Met	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.004	-5.159	4.155	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83N	83	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly83Asn	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.004	-3.021	2.017	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83P	83	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly83Pro	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.004	-4.257	3.253	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83Q	83	G	Q	missense	low	0.500971894042221	0.200953084589926	6	0.0820387532472772	0.340178892340989	0.661764895743453	0.54293121578757	0.885696518596628	0.412738777783591	0.447170608406035	NA	NA	0.33691296778002	0.380381275899482	0.55612154604025	0.588924094963857	0.648825625702017	0.542018849043898	0.541236998275452	NA	NA	0.555036425910595	0.557206666169905	NA	NA	p.Gly83Gln	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.004	-3.207	2.203	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83R	83	G	R	missense	low	0.548268668453413	0.204730375526369	6	0.0835808258146649	0.384453260058554	0.712084076848272	0.779643152238814	0.837160205309412	0.454050518260216	0.430521666170502	NA	NA	0.360103292994347	0.428133175747185	0.563876466237113	0.639343446237942	0.638331503518429	0.554379941592448	0.535722804133635	NA	NA	0.559806793484582	0.567946138989645	NA	NA	p.Gly83Arg	1	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.004	-3.534	2.53	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83S	83	G	S	missense	possibly_wt-like	0.756686281122733	0.0922815776374462	6	0.0376737963117956	0.682846997190716	0.83052556505475	0.780206203792957	0.900655226054368	0.807981866146152	0.710600874121471	NA	NA	0.641774352704328	0.698899163917122	0.634152592629311	0.63946337552634	0.652059874311736	0.660281510893948	0.628486122420111	NA	NA	0.617747959783569	0.628841809732282	NA	NA	p.Gly83Ser	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.004	-3.184	2.18	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83T	83	G	T	missense	low	0.376530906734458	0.271065421105345	6	0.110661994770124	0.159637382527655	0.593424430941261	0.742874048867045	0.633656202632612	0.071357593841857	0.308493601620888	NA	NA	0.389219417584183	0.113584575860165	0.531499911125887	0.631511672451088	0.594331542987804	0.439872477083975	0.495306636598342	NA	NA	0.565796128060092	0.497203694191683	NA	NA	p.Gly83Thr	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.004	-3.193	2.189	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83V	83	G	V	missense	low	-0.0325731040763097	0.162259239731825	6	0.0662420572324837	-0.162405150513819	0.0972589423611993	0.202683190297384	0.113771211792636	-0.164396068086166	-0.0275874833642267	NA	NA	-0.210073647232208	-0.109835827865278	0.444737309449154	0.516451684088892	0.481926289152318	0.3693314444349	0.383995279769613	NA	NA	0.442518503563956	0.446956115334353	NA	NA	p.Gly83Val	1	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.004	-4.032	3.028	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83W	83	G	W	missense	low	0.145232899617765	0.416000832880003	6	0.169831628854805	-0.187630976373425	0.478096775608956	0.62535442225052	0.601480004721981	-0.203759019211523	0.0170608958241982	NA	NA	-0.386815700071765	0.21807679419318	0.463432957446605	0.606480136547962	0.58737467029994	0.357553458897837	0.398782995858685	NA	NA	0.406161766431837	0.520704148461372	NA	NA	p.Gly83Trp	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.004	-4.005	3.001	0.004005347	NA	NA	NA	NA	NA	NA	NA
G83X	83	G	X	nonsense	low	0.223960067895626	0.217720160184233	6	0.0888838831947314	0.0497508580278874	0.398169277763364	-0.141060057748851	0.108387195065623	0.362894933192595	0.467720005931521	NA	NA	0.331644704968537	0.214173625964331	0.523465571549075	0.443234795109118	0.480762201368448	0.527104822937604	0.548043038313903	NA	NA	0.553952717516907	0.519826320160545	NA	NA	p.Gly83Ter	1	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G83Y	83	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly83Tyr	0	18.2	29.5	29.3	0.54	82.5	125.8	93	8.7	52.5773195876289	-2.2	0	0	17.2	0	0	0	0	6	24.366028870486	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.004	-4.535	3.531	0.004005347	NA	NA	NA	NA	NA	NA	NA
H84A	84	H	A	missense	wt-like	1.07482434515222	0.141301003408164	6	0.0576858930822116	0.961762072295061	1.18788661800939	0.856989781264359	0.955583090669589	1.13586026862722	1.17439684189779	NA	NA	1.0961661296991	1.22994995875528	0.729747286049534	0.655818183072806	0.663935925118164	0.758387648059296	0.782097143008082	NA	NA	0.711218654085122	0.748275918013946	NA	NA	p.His84Ala	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.723	-3.079	1.356	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84C	84	H	C	missense	possibly_wt-like	0.854225598033988	0.371797795129776	3	0.214657557102286	0.433504517104158	1.27494667896382	0.847345678385214	1.22941560895801	0.485915506758738	NA	NA	NA	NA	NA	0.653764001023194	0.653764001023194	0.723141738459475	0.563914424220009	NA	NA	NA	NA	NA	NA	NA	p.His84Cys	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.723	-3.162	1.439	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84D	84	H	D	missense	possibly_low	0.494293811689058	0.391987540373727	6	0.160028243240708	0.180644218428054	0.807943404950062	0.777049354939045	0.991677143783649	0.301793253199516	-0.120458025475967	NA	NA	0.62095765594745	0.394743487740652	0.586951304229187	0.638790970603838	0.671739884212429	0.508822283578275	0.353236196578914	NA	NA	0.613465859628062	0.560436748830312	NA	NA	p.His84Asp	1	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.723	-3.265	1.542	0.007522687	NA	NA	NA	NA	4.06e-06	NA	NA
H84E	84	H	E	missense	low	0.0679291563731921	0.286696346890247	6	0.117043293500178	-0.161471483519108	0.297329796265492	0.509630467043556	0.325547251802254	-0.00612429149309057	-0.0572494249262924	NA	NA	-0.141435526332557	-0.222793537854717	0.43909473640828	0.581831076446136	0.527714761512511	0.41668873453497	0.374171129857712	NA	NA	0.456637713331517	0.421551759485043	NA	NA	p.His84Glu	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.723	-3.085	1.362	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84F	84	H	F	missense	wt-like	1.05062953330253	0.174661782816403	6	0.071305374244167	0.910873567879814	1.19038549872525	0.851732660318902	0.898397214170533	1.06313750428429	1.02898059127161	NA	NA	1.12059060354486	1.34093862622498	0.725088804984064	0.654698422778445	0.651571665566652	0.736627905911955	0.733934717672947	NA	NA	0.716242892295181	0.773237433291697	NA	NA	p.His84Phe	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.723	-2.36	0.637	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84G	84	H	G	missense	low	0.159866971134932	0.224564952784044	6	0.0916782580721842	-0.0198191128519173	0.339553055121782	0.478216624206808	0.416435702321933	-0.0207663764544116	0.0395001230950523	NA	NA	0.0359635893848358	0.00985216425537546	0.483501866604727	0.575139966565493	0.547365914231638	0.412307603040086	0.406214954827211	NA	NA	0.493129611631818	0.473874121577635	NA	NA	p.His84Gly	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.723	-4.017	2.294	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84H	84	H	H	synonymous	wt-like	1.1818697548766	0.534244582069888	8	0.188883983396896	0.811663950162225	1.55207555959098	1.11630535002471	1.02643290940263	0.847496723742523	0.698008618434346	2.08617434357359	1.95690964348583	0.872092988412985	0.851537461936203	0.675679719462695	0.711052080222984	0.679254489799207	0.672104949126183	0.624315518572738	0.811015766560688	0.855996919384283	0.665125671881828	0.663170388449682	NA	NA	p.His84=	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	0	-3.2	-3.2	0	216	216	0	10.4	10.4	0	155	155	0	7.59	7.59	0	NA	NA	NA	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84I	84	H	I	missense	possibly_low	0.52710942007736	0.246814610559296	6	0.100761642822337	0.329620229122491	0.72459861103223	0.371143024459471	0.742344267004515	0.328054448113316	0.260369588473779	NA	NA	0.872729273018934	0.588015919394148	0.578118712883184	0.552333421535375	0.617831181715347	0.516680027091857	0.479367777082682	NA	NA	0.665256558854045	0.603904004230992	NA	NA	p.His84Ile	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.723	-3.265	1.542	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84K	84	H	K	missense	low	-0.108969663466741	0.246120241763656	6	0.100478167948565	-0.305903253878496	0.0879639269450134	0.103021217459863	0.166489513260447	-0.183258619582861	0.0320283975176365	NA	NA	-0.425498480994126	-0.346600008461406	0.400972406242529	0.495223806473188	0.493324606400698	0.363687486033187	0.403740290381543	NA	NA	0.398204522103515	0.393707501346015	NA	NA	p.His84Lys	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.723	-3.674	1.951	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84L	84	H	L	missense	possibly_low	0.692514282393971	0.104219556625245	6	0.0425474558251581	0.609122801342852	0.77590576344509	0.744283551527999	0.778953692270445	0.637207965291508	0.75252087531283	NA	NA	0.504257222561889	0.737862387399154	0.628779232559263	0.631811894783978	0.625746570334548	0.609183397646082	0.642370189150848	NA	NA	0.589459988293894	0.637604696253851	NA	NA	p.His84Leu	1	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.723	-2.577	0.854	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84M	84	H	M	missense	possibly_wt-like	0.931732542146821	0.413868519522658	6	0.168961115571935	0.600574840838118	1.26289024345552	1.38143674692462	1.5350002949768	0.739272060971007	0.636512545119633	NA	NA	0.705197372112923	0.592976232775945	0.635258451523323	0.767524741612573	0.789212744173028	0.639722506335829	0.603947780945959	NA	NA	0.630794396710816	0.605019586038441	NA	NA	p.His84Met	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.723	-3.56	1.837	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84N	84	H	N	missense	possibly_low	0.695695617604926	0.171594622680946	6	0.0700532113622879	0.558393846333469	0.832997388876382	0.739822025187989	0.683480505033593	0.97218563215101	0.708585931179432	NA	NA	0.626974182480816	0.443125429596713	0.62126112759057	0.630861595161881	0.605104143576849	0.70941374122336	0.627818765514795	NA	NA	0.614703489666345	0.571317919028495	NA	NA	p.His84Asn	1	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.723	-3.151	1.428	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84P	84	H	P	missense	low	0.154250418943823	0.228579279316704	6	0.0933171000165061	-0.028647736230251	0.337148574117897	-0.201374121207886	-0.0287954072720669	0.164601844306307	0.401146324085683	NA	NA	0.312334962971197	0.277588910779704	0.496883066420076	0.430387973787394	0.451101708164621	0.46777255576169	0.525993577078461	NA	NA	0.549980605602355	0.534088511399069	NA	NA	p.His84Pro	1	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.723	-3.91	2.187	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84Q	84	H	Q	missense	low	0.417907310622882	0.242883080402589	6	0.0991566023569539	0.223563941173893	0.612250680071871	0.552904197510108	0.781370010428333	0.36993690254067	0.44645657220169	NA	NA	0.0626804284388516	0.294095752617638	0.539400715616733	0.591048327802544	0.626269006759277	0.529211885816857	0.541000506719451	NA	NA	0.498625400997634	0.537800924514016	NA	NA	p.His84Gln	1	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.723	-3.686	1.963	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84R	84	H	R	missense	low	0.0132589449626417	0.105457213475932	6	0.043052727118632	-0.0711228496261078	0.0976407395513913	-0.0772681923905213	-0.022675483532398	0.168215053255817	0.121648685178727	NA	NA	-0.0329201224491203	-0.0774462702866544	0.455531479320073	0.456822383957191	0.452424907705927	0.468853682088174	0.433422876711502	NA	NA	0.478959882562839	0.454240574682954	NA	NA	p.His84Arg	1	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.723	-3.632	1.909	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84S	84	H	S	missense	low	0.535121387741477	0.140452193969651	6	0.057339368080009	0.422738291408374	0.64750448407458	0.684692959601047	0.728384977240626	0.372708224736616	0.493606599112852	NA	NA	0.489776953031069	0.441558612726651	0.578723431486111	0.619119172008613	0.614813018973742	0.53004110699589	0.556616778221982	NA	NA	0.586481323372466	0.570965539599756	NA	NA	p.His84Ser	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.723	-3.601	1.878	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84T	84	H	T	missense	possibly_low	0.680283129297264	0.175945695012126	6	0.0718295292031767	0.53949983903257	0.821066419561959	0.892911162664227	0.859530524956101	0.71458378422798	0.63046325291764	NA	NA	0.453611025713163	0.530599025304475	0.617139817739996	0.663469393122466	0.643168229914789	0.632335403537354	0.601944231942637	NA	NA	0.579041808602147	0.590990859928115	NA	NA	p.His84Thr	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.723	-4.09	2.367	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84V	84	H	V	missense	possibly_wt-like	0.771732421167629	0.132765267251278	6	0.0542011933883121	0.665500034207446	0.877964808127811	0.857848679939649	0.993888670592036	0.644528163337909	0.760837951298873	NA	NA	0.669550191055208	0.703740870782097	0.637527776842186	0.656001127434073	0.672218042337092	0.611373710726124	0.645124836925492	NA	NA	0.623461590678554	0.629930716758879	NA	NA	p.His84Val	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.723	-3.045	1.322	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84W	84	H	W	missense	possibly_low	0.702627939104111	0.20825676361809	6	0.085020467724622	0.535990884415102	0.86926499379312	0.986513509500896	0.900359668508986	0.732716842394871	0.470043410503406	NA	NA	0.603130704038236	0.523003499678271	0.623779925874586	0.683406577854208	0.651995971291843	0.637761086590238	0.548812558905548	NA	NA	0.609798765158934	0.589282614993894	NA	NA	p.His84Trp	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.723	-4.307	2.584	0.007522687	NA	NA	NA	NA	NA	NA	NA
H84X	84	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His84Ter	0	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H84Y	84	H	Y	missense	possibly_low	0.638289535516756	0.234991124241267	6	0.0959347247456783	0.450260930148463	0.826318140885049	0.79009604622364	0.989500717842535	0.545925632591364	0.65761764074709	NA	NA	0.542384165695849	0.304213010000057	0.604120382158163	0.641569899798134	0.671269315308392	0.581870354197999	0.610937870347737	NA	NA	0.597302893968589	0.540076310645569	NA	NA	p.His84Tyr	1	19.2	28.7	25.7	0.61	59.9	-119.6	-96.4	153.6	2.77777777777778	-3.1	0	0	16.12	1	21	0	0	9	21.5442432557472	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.723	-2.221	0.498	0.007522687	NA	NA	NA	NA	NA	NA	NA
S85A	85	S	A	missense	wt-like	1.03216836114196	0.117453926033105	6	0.0479503645112841	0.938187373654278	1.12614934862965	0.962300162161521	0.97264750507623	0.932776748791763	0.962230554359448	NA	NA	1.2056778915669	1.15737730489591	0.704724429514699	0.678249164656852	0.667625452353473	0.697622012072798	0.711826846956599	NA	NA	0.733745779209763	0.731954220949226	NA	NA	p.Ser85Ala	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.368	-2.639	0.271	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85C	85	S	C	missense	wt-like	1.15150227439233	0.285954618001068	6	0.116740483949183	0.922695130314154	1.3803094184705	0.712462727154823	0.870603801449573	1.40692490040439	1.302293496235	NA	NA	1.30791545843648	1.30881326267371	0.760394478540555	0.625034098336723	0.645562402620233	0.839494252655921	0.824457010207273	NA	NA	0.754776565510968	0.766012391570141	NA	NA	p.Ser85Cys	1	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.368	-3.641	1.273	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85D	85	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser85Asp	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.368	-2.731	0.363	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85E	85	S	E	missense	wt-like	1.10145834380989	0.127996060910057	6	0.0522541730526392	0.999042046584797	1.20387464103499	1.03264818819923	1.10211645370584	1.28508161489787	1.21375639600041	NA	NA	1.03713128420041	0.93801612585559	0.697346524818949	0.693233207664605	0.695618162839329	0.80303691362375	0.795133179747639	NA	NA	0.699074886798569	0.682619567720282	NA	NA	p.Ser85Glu	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.368	-2.359	-0.009	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85F	85	S	F	missense	wt-like	1.04449816723394	0.140658072133699	6	0.0574234174885254	0.931950337087219	1.15704599738065	1.01294608287206	0.922238199139858	1.15748555853662	1.26586570324703	NA	NA	0.904664490999245	1.00378896860882	0.693224330344109	0.689036683466364	0.656726367114844	0.764858259243313	0.812391984102198	NA	NA	0.671825795245235	0.697411977221854	NA	NA	p.Ser85Phe	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.368	-4.167	1.799	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85G	85	S	G	missense	possibly_low	0.523657120174103	0.290788269630479	6	0.118713813963588	0.290982320338083	0.756331920010123	0.838026122818811	0.923677588256013	0.409031049506938	0.419235270603339	NA	NA	0.183195829518702	0.368776860340817	0.547753128542098	0.651778947151956	0.657037579982729	0.540909441116665	0.531984706214966	NA	NA	0.523416030545257	0.554596815967531	NA	NA	p.Ser85Gly	1	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.368	-3.129	0.761	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85H	85	S	H	missense	wt-like	1.15958349643562	0.224689457276889	6	0.0917290868185433	0.979797789936527	1.33936920293471	0.81679187668211	1.01936906763702	1.46022586460827	1.24936646262755	NA	NA	1.1267278758617	1.28501983119707	0.739083287017396	0.647256078846043	0.677727204071197	0.855442700817381	0.806927371715341	NA	NA	0.717505360353837	0.760661213680955	NA	NA	p.Ser85His	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.368	-2.946	0.578	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85I	85	S	I	missense	wt-like	1.00748841915382	0.116006283216199	6	0.04735936680608	0.914665765883278	1.10031107242436	0.806829163028226	0.965442217019195	1.11966346284953	1.00949710636783	NA	NA	1.11870179124091	1.02479677441722	0.708995508901339	0.645134033093349	0.666067584272496	0.753541320770756	0.727481712022574	NA	NA	0.715854354019634	0.702136663783044	NA	NA	p.Ser85Ile	1	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.368	-3.84	1.472	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85K	85	S	K	missense	wt-like	0.97786773146078	0.172808508184339	6	0.0705487780438669	0.839594667341491	1.11614079558007	0.842358326111241	0.912563119121298	0.860716749030466	1.03819879962262	NA	NA	1.30179312787708	0.911576267001977	0.676366891718072	0.652701701124005	0.654634500943429	0.676060579031703	0.736987823976521	NA	NA	0.753517171047636	0.67667320440444	NA	NA	p.Ser85Lys	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.368	-2.712	0.344	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85L	85	S	L	missense	wt-like	0.913509488129205	0.133998639107775	6	0.0547047153402333	0.806290216277831	1.02072875998058	0.987608472297975	1.08990450504708	0.929278999409076	0.930624820065569	NA	NA	0.692829819134045	0.850810312821488	0.688308799696552	0.683639803583022	0.692977795810081	0.696575432980942	0.70135890536454	NA	NA	0.62825032830493	0.663006851539564	NA	NA	p.Ser85Leu	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.368	-4.05	1.682	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85M	85	S	M	missense	wt-like	0.978976176846277	0.27687348195441	6	0.113033125682665	0.757435321448263	1.20051703224429	0.789743803622798	1.02482953257655	1.31870007660119	1.29353812784818	NA	NA	0.739472031667211	0.707573488761735	0.660201346707919	0.641494872557464	0.678907820858374	0.813096061741457	0.821557198292193	NA	NA	0.637844868105076	0.630792678204435	NA	NA	p.Ser85Met	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.368	-5.223	2.855	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85N	85	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser85Asn	1	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.368	-2.955	0.587	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85P	85	S	P	missense	possibly_low	0.651796925127039	0.293434794911844	6	0.119794253385375	0.417004502936839	0.886589347317238	0.973904984982203	1.02281343109114	0.641229849336641	0.547619827699786	NA	NA	0.288828092314061	0.436385365338404	0.59244648719497	0.680720977642041	0.678471915988607	0.610386805692507	0.574506168697433	NA	NA	0.545145123024499	0.569802068619688	NA	NA	p.Ser85Pro	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.368	-2.741	0.373	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85Q	85	S	Q	missense	wt-like	1.16701593179116	0.146582269474017	6	0.0598419609250807	1.04972784361375	1.28430401996857	1.10040937153364	1.19237471731961	1.04062882881165	1.19359727268506	NA	NA	1.04296111173146	1.43212428866554	0.722513017123202	0.707666256358745	0.715133061732378	0.729892972514026	0.78845640003893	NA	NA	0.700274111904688	0.793745223483368	NA	NA	p.Ser85Gln	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.368	-2.681	0.313	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85R	85	S	R	missense	possibly_wt-like	0.808071241208065	0.195506238103944	6	0.0798150874809562	0.651636544322477	0.964505938093652	1.03078209854395	0.997341774550035	0.766749382094583	0.87314668967831	NA	NA	0.541136509196415	0.639270993185099	0.660454388555585	0.692835732863589	0.672964644054315	0.647944133056856	0.68232192599491	NA	NA	0.597046244695525	0.615431346045816	NA	NA	p.Ser85Arg	1	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.368	-2.287	-0.081	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85S	85	S	S	synonymous	wt-like	1.25859747077865	0.126580519938255	6	0.0516762808708195	1.15731382141687	1.35988112014043	1.20918409437291	1.10636010369498	1.22271400508313	1.26491182392092	NA	NA	1.48917791100787	1.2592368865921	0.769619090209595	0.730835138514816	0.696535689912859	0.784375589069098	0.812076055575471	NA	NA	0.792063171806321	0.754862591350093	NA	NA	p.Ser85=	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85T	85	S	T	missense	possibly_low	0.502863265808024	0.40701127245928	6	0.166161656181023	0.177192404081692	0.828534127534356	1.0676804291272	0.955400326460039	0.211863071491938	0.281306994331779	NA	NA	0.397610534217372	0.103318239219813	0.531208501623178	0.700695031887522	0.663896409345006	0.481913823993421	0.486302326983433	NA	NA	0.567522223331571	0.494894779914785	NA	NA	p.Ser85Thr	1	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.368	-2.742	0.374	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85V	85	S	V	missense	wt-like	1.08315866955769	0.088540690627663	6	0.0361465855852332	1.01231266364654	1.15400467546885	1.24704490038446	1.11228039204759	1.02642370837969	1.0703629125604	NA	NA	1.00585411011618	1.03698599385785	0.715260312302243	0.738899443620992	0.697815725933863	0.725642587362081	0.747640702737774	NA	NA	0.692641013375993	0.704878037242404	NA	NA	p.Ser85Val	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.368	-3.776	1.408	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85W	85	S	W	missense	wt-like	0.863293714270724	0.113012750212142	6	0.0461372620747267	0.772866342258974	0.953721086282474	0.85191741928784	0.970487766728696	0.898017606774676	0.943437393121109	NA	NA	0.6520819993257	0.863820100386325	0.666545631742929	0.654737776211549	0.667158491503573	0.687221555291645	0.705602479177516	NA	NA	0.619868294998891	0.665932771982285	NA	NA	p.Ser85Trp	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.368	-5.91	3.542	0.008933198	NA	NA	NA	NA	NA	NA	NA
S85X	85	S	X	nonsense	low	-0.088997135831037	0.167931641683491	6	0.0685578056320753	-0.223367965729002	0.0453736940669279	-0.204141855125119	0.167592289971133	0.00735540773127089	-0.0542730392715143	NA	NA	-0.309771783908956	-0.140743834383037	0.425904270403643	0.429798449867738	0.493563039704741	0.420722062778141	0.375156920312696	NA	NA	0.422010090939547	0.44000485900804	NA	NA	p.Ser85Ter	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S85Y	85	S	Y	missense	wt-like	1.09625557084286	0.246488190485883	6	0.100628382385393	0.899027565544961	1.29348357614075	0.807141121007431	1.10882592972991	1.01640955279321	1.05506317347175	NA	NA	1.55285376374578	1.03723988430905	0.713790669674346	0.645200479759166	0.697068830523291	0.722646201768741	0.742573369903026	NA	NA	0.80516161783239	0.704935137579952	NA	NA	p.Ser85Tyr	0	16.7	27.8	22.9	0.86	29.4	-156.4	-99.2	134.6	28.6713286713287	-6.3	0	1	17.09	0	0	0	0	6	19.6199235289282	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.368	-3.606	1.238	0.008933198	NA	NA	NA	NA	NA	NA	NA
V86A	86	V	A	missense	possibly_low	0.690966290847794	0.118095715609012	6	0.0482123740084859	0.596471774181986	0.785460807513601	0.77900198675013	0.880913699732746	0.665570200657718	0.62748346008824	NA	NA	0.637325450194759	0.55550294766317	0.617251300973294	0.639206878777579	0.647791523971987	0.617669803984828	0.600957313018225	NA	NA	0.61683279796176	0.596591788857207	NA	NA	p.Val86Ala	1	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-0.856	-3.271	2.415	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86C	86	V	C	missense	possibly_low	0.705536967811661	0.256822828621803	6	0.104847480736945	0.500039681697492	0.91103425392583	0.833304174717971	1.10755990656233	0.331046785827481	0.700372717107367	NA	NA	0.642777482909261	0.618160739745552	0.621526412982647	0.650773178015158	0.696795101413929	0.517575379429826	0.625098517208268	NA	NA	0.617954308757025	0.610683618861036	NA	NA	p.Val86Cys	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-0.856	-4.998	4.142	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86D	86	V	D	missense	low	0.211997611273532	0.0560646594324572	6	0.0228883013687393	0.167137364923504	0.25685785762356	0.210723066853711	0.264662695936955	0.257690212601408	0.195160238833168	NA	NA	0.232496471658849	0.111252981757101	0.505615059591817	0.518164167905174	0.5145508039502	0.495625992155644	0.45777018795702	NA	NA	0.533557422805542	0.496679315233434	NA	NA	p.Val86Asp	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-0.856	-4.258	3.402	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86E	86	V	E	missense	low	0.0812028021643659	0.145979171643401	6	0.0595957472667492	-0.0356027161102138	0.198008320438946	-0.0606219303238354	-0.124086300680785	0.145975130550886	0.174966000615833	NA	NA	0.0932610584776234	0.257722854346473	0.461283590425253	0.460368017300078	0.430498695478083	0.462199163550428	0.451081778056791	NA	NA	0.504915991775503	0.529620605959064	NA	NA	p.Val86Glu	1	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-0.856	-4.062	3.206	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86F	86	V	F	missense	low	-0.0601783197130881	0.101323666044534	6	0.0413652134462126	-0.141252648280477	0.0208960088543005	-0.0696673859427704	0.080574134857086	-0.0245126828053311	-0.00222778125493995	NA	NA	-0.200144625212277	-0.145091577920296	0.44179399942052	0.458441346380467	0.474748690403973	0.411186651974247	0.392394511314233	NA	NA	0.444560953777462	0.439027045063579	NA	NA	p.Val86Phe	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-0.856	-4.133	3.277	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86G	86	V	G	missense	low	0.00125700514420964	0.0850786146814306	6	0.0347331989987278	-0.0668188139611594	0.0693328242495787	-0.12224771983323	-0.0200973398993238	-0.0014613093383187	0.0101149039429932	NA	NA	-0.0027829412899654	0.144016437283102	0.450112066323123	0.44724179994324	0.452982332703006	0.418083968754162	0.396482456449118	NA	NA	0.485159253655926	0.50404786478276	NA	NA	p.Val86Gly	1	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-0.856	-3.981	3.125	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86H	86	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val86His	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-0.856	-5.24	4.384	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86I	86	V	I	missense	wt-like	0.899889286082407	0.142797368144105	6	0.0582967814275698	0.785629694069767	1.01414887809505	0.91350467772795	1.10235131665993	0.940486748708802	0.96905958627119	NA	NA	0.711877230406734	0.762056156719838	0.681762364736131	0.667855786498027	0.695668942974236	0.699928959720713	0.71408864877135	NA	NA	0.632168477458245	0.643045910715583	NA	NA	p.Val86Ile	1	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-0.856	-1.741	0.885	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86K	86	V	K	missense	low	0.217357502084757	0.152804471707181	6	0.0623821643496903	0.0950907066817055	0.339624297487808	0.0093926608733501	0.187064752149693	0.199696080107974	0.119458154662149	NA	NA	0.400940617034621	0.387592747680754	0.48802324642029	0.475281039096971	0.497773215209994	0.478273277630585	0.432697364521532	NA	NA	0.568207238265311	0.558828536827036	NA	NA	p.Val86Lys	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-0.856	-4.065	3.209	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86L	86	V	L	missense	low	0.222784679063273	0.27861525151775	6	0.113744200129281	-0.0001498566404326	0.445719214766979	0.668300147179005	0.425027853730685	0.167531478666393	0.118266251284107	NA	NA	-0.109818299374747	0.0674006428941965	0.477733002877694	0.615627523128256	0.549223638492024	0.468649146315383	0.432302601507052	NA	NA	0.463141537355759	0.486816859440006	NA	NA	p.Val86Leu	1	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-0.856	-2.688	1.832	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86M	86	V	M	missense	low	0.16321830035421	0.228760770081205	6	0.0933911933108486	-0.0198250750082713	0.346261675716691	-0.0853956211908136	0.397377776426007	0.0278334200118672	-0.0274053952875492	NA	NA	0.460717076640747	0.206182545525002	0.486560182992572	0.455091251620646	0.543245366349599	0.426849391283073	0.384055588045749	NA	NA	0.580503559337023	0.518029114364498	NA	NA	p.Val86Met	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-0.856	-3.539	2.683	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86N	86	V	N	missense	low	-0.118183942033042	0.174812285193447	6	0.0713668165823061	-0.258060332225637	0.0216924481595541	-0.21907965979865	-0.126352235314121	-0.0041700973344506	0.0938497848574026	NA	NA	-0.401392088880717	-0.0519593557277136	0.425416244560574	0.426616715847943	0.430008773741309	0.417273458745911	0.424215773273205	NA	NA	0.403163329287148	0.459972619419137	NA	NA	p.Val86Asn	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-0.856	-4.458	3.602	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86P	86	V	P	missense	low	0.136881486584778	0.120725564019715	6	0.0492860051263343	0.0402826915953066	0.23348028157425	0.0847968096190474	0.249506367051289	0.124730671763394	0.305623193614453	NA	NA	-0.0230736001402736	0.0797054776007609	0.490463132482616	0.49134203002176	0.511273827261847	0.455842502751675	0.494355946350891	NA	NA	0.480985362167137	0.489584234943473	NA	NA	p.Val86Pro	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-0.856	-3.419	2.563	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86Q	86	V	Q	missense	low	-0.0406653172964912	0.133769781715391	6	0.0546112847010325	-0.147701468459978	0.0663708338669958	-0.0156916444995484	0.120258305360643	0.0990891218347591	-0.10348028948686	NA	NA	-0.221747921117269	-0.122419475870672	0.446148100311122	0.46993811290988	0.483328875131937	0.448170166314157	0.358859288485176	NA	NA	0.440117046185655	0.444126034308088	NA	NA	p.Val86Gln	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-0.856	-4.498	3.642	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86R	86	V	R	missense	low	0.133748081071439	0.071794970153515	6	0.0293101738290766	0.0763011959858401	0.191194966157037	0.0381880148222695	0.0564127867396408	0.162405942756209	0.186146070130797	NA	NA	0.141746571451042	0.217589100528674	0.475469568319126	0.481414414065627	0.469524722572624	0.467115509072901	0.454784660375221	NA	NA	0.514889707829886	0.520594465435754	NA	NA	p.Val86Arg	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-0.856	-4.476	3.62	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86S	86	V	S	missense	low	0.477298137883889	0.161820871734433	6	0.0660630942469544	0.347816852452583	0.606779423315194	0.535610876110541	0.755020795990589	0.498214637417507	0.416612334482514	NA	NA	0.294577110216126	0.363753073086054	0.560530733714314	0.58736487161773	0.620571996479263	0.567594508636345	0.53111597961437	NA	NA	0.546327725179872	0.553466958792282	NA	NA	p.Val86Ser	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-0.856	-3.946	3.09	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86T	86	V	T	missense	low	0.525740794002522	0.205159104801356	6	0.0837558538082503	0.36158233704395	0.689899250961095	0.546802782780706	0.879164575884967	0.286919138562263	0.539672257760785	NA	NA	0.542266678958657	0.359619330067754	0.580811318363648	0.589748733970806	0.647413342809685	0.504371725323223	0.57187390275649	NA	NA	0.597278726350572	0.552537273880679	NA	NA	p.Val86Thr	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-0.856	-3.615	2.759	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86V	86	V	V	synonymous	possibly_wt-like	0.86707523074003	0.238174610529671	6	0.0972343775806346	0.676499352622817	1.05765110885724	1.03115890239907	1.17120950560226	0.852477798078399	0.9529095168598	NA	NA	0.67194094949897	0.522754712001678	0.683255676459745	0.692915991621208	0.710556893853927	0.673595361298282	0.708739683240785	NA	NA	0.623953381822143	0.589226662277894	NA	NA	p.Val86=	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86W	86	V	W	missense	low	-0.0622262111344319	0.0783399603785704	6	0.0319821548995581	-0.124910082885547	0.000457660616683182	-0.00170085615447109	-0.0520529218948383	-0.105304387039702	0.0549423849751526	NA	NA	-0.155270038845138	-0.113971447847594	0.446049584031655	0.472918133616681	0.446073159772541	0.38701256195349	0.411329491762411	NA	NA	0.453791883905583	0.446026008290769	NA	NA	p.Val86Trp	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-0.856	-5.654	4.798	0.003499914	NA	NA	NA	NA	NA	NA	NA
V86X	86	V	X	nonsense	low	-0.0959449940196189	0.264378783273606	6	0.107932186306366	-0.307488191952763	0.115598203913526	-0.0484272376353109	-0.197954079546103	-0.45034207029973	-0.0954428998133396	NA	NA	-0.144565688067468	0.361062011244237	0.435260717737643	0.462965471841492	0.414527612296388	0.283772110539259	0.36152130307002	NA	NA	0.455993823178898	0.552861735008546	NA	NA	p.Val86Ter	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V86Y	86	V	Y	missense	low	0.158239316528794	0.264071110730754	6	0.107806579516724	-0.0530576966204381	0.369536329678025	-0.206192091637906	-0.101817623340734	0.197463562011547	0.499674215587793	NA	NA	0.266275474330329	0.294032362221732	0.507695971321054	0.429361752012602	0.435313445611463	0.477605274721779	0.558626396295465	NA	NA	0.540505935063839	0.537786667920329	NA	NA	p.Val86Tyr	0	17.3	24.4	21.4	0.892	13.9	-176	-116.7	134.2	1.21212121212121	-6.1	0	1	14.52	0	0	0	0	7	15.8652106311861	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-0.856	-4.299	3.443	0.003499914	NA	NA	NA	NA	NA	NA	NA
V87A	87	V	A	missense	wt-like	1.05991626521655	0.0860694517825845	6	0.035137706551402	0.99104762587646	1.12878490455663	1.03115810000688	1.03254443302765	1.10655616336122	1.07111329616709	NA	NA	0.930296746042408	1.18782885269402	0.71585931987391	0.692915820712659	0.68057587313686	0.749619420115708	0.747889232694189	NA	NA	0.677098480176385	0.738802819035161	NA	NA	p.Val87Ala	1	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.59	-2.64	1.05	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87C	87	V	C	missense	possibly_wt-like	0.946343864841889	0.319432069275909	6	0.130407596201224	0.690749672977048	1.20193805670673	1.48895834200683	1.12153186963516	0.594461416671706	0.722038953746808	NA	NA	0.854304786854602	0.896767820136239	0.667404655692142	0.790426709097919	0.699816004274085	0.59639298897474	0.632274458686246	NA	NA	0.661466548556501	0.673342762827783	NA	NA	p.Val87Cys	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.59	-5.239	3.649	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87D	87	V	D	missense	low	0.427392953309953	0.210416065246414	6	0.0859019989229813	0.259028129220911	0.595757777398995	0.774665514147329	0.59231792789104	0.339660509644683	0.243549061018505	NA	NA	0.267514155501322	0.346650551656839	0.545190657261778	0.638283215447673	0.585393721455507	0.520152734827193	0.47379675325162	NA	NA	0.540760738066298	0.549620576457257	NA	NA	p.Val87Asp	1	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.59	-4.328	2.738	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87E	87	V	E	missense	low	0.370887591353154	0.230933444386313	6	0.0942781838816439	0.186105746417288	0.555669436289021	0.585959046418999	0.732497354852509	0.292181389563134	0.202103681319512	NA	NA	0.225886169414003	0.18669790655077	0.522922320182417	0.598088969957877	0.615702163414292	0.505946269771968	0.460069882997136	NA	NA	0.532197650090342	0.513646990274492	NA	NA	p.Val87Glu	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.59	-3.651	2.061	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87F	87	V	F	missense	wt-like	0.997072019473573	0.288876679722126	6	0.117933410651435	0.765926782022788	1.22821725692436	1.12103643247274	1.17515114640554	0.834993990430413	0.857395390332762	NA	NA	1.39966225512061	0.594192902079374	0.694257078820679	0.712059794964495	0.71140912298696	0.668363943741327	0.677105034654399	NA	NA	0.773649347150473	0.60529321676217	NA	NA	p.Val87Phe	1	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.59	-3.269	1.679	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87G	87	V	G	missense	low	0.570686451478744	0.139078317809714	6	0.0567784854864054	0.45940266482866	0.681970238128829	0.746978837732004	0.735926350620906	0.510893970096388	0.548485954920831	NA	NA	0.423853184855722	0.457980410646615	0.574725929799528	0.632385987429838	0.61644355265718	0.57138835520125	0.57479303338714	NA	NA	0.572920469734054	0.574658826211915	NA	NA	p.Val87Gly	1	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.59	-4.065	2.475	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87H	87	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val87His	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.59	-4.184	2.594	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87I	87	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val87Ile	1	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.59	-1.998	0.408	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87K	87	V	K	missense	low	0.549552408400138	0.152906997383526	6	0.0624240202817867	0.427203576877638	0.671901239922638	0.541121855363282	0.758159302514114	0.627154428241422	0.605479966875599	NA	NA	0.447834128974609	0.317564768431803	0.591104187138215	0.58853870341926	0.62125057852848	0.60617522852799	0.593669670857169	NA	NA	0.577853471628639	0.543079140841452	NA	NA	p.Val87Lys	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.59	-3.634	2.044	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87L	87	V	L	missense	possibly_low	0.665620153379164	0.158052260078563	6	0.0645245649810232	0.539154329898244	0.792085976860083	0.468150118780636	0.90940833099538	0.688909716552281	0.587480284263533	NA	NA	0.7693619923648	0.570410477318352	0.612298925800819	0.572995813292981	0.653952398620148	0.624653337302052	0.587708106271872	NA	NA	0.64399338469472	0.599944514299586	NA	NA	p.Val87Leu	1	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.59	-1.854	0.264	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87M	87	V	M	missense	possibly_wt-like	0.738248994269234	0.265577028471261	6	0.108421367859865	0.525747018109329	0.950750970429138	1.04911769154137	1.08048043289482	0.678996344218867	0.623613722504185	NA	NA	0.55955179707401	0.437733977382147	0.611260735214442	0.696741191616601	0.690940200493611	0.621687107570073	0.599675640944739	NA	NA	0.600834362858811	0.570105373460634	NA	NA	p.Val87Met	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.59	-3.399	1.809	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87N	87	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val87Asn	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.59	-3.822	2.232	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87P	87	V	P	missense	low	-0.140642678561753	0.114910571323504	6	0.0469120442990465	-0.232588595829031	-0.048696761294474	-0.0477661049330119	0.00956376550780894	-0.24556179274823	-0.274260623344174	NA	NA	-0.0883168727728645	-0.197514443080044	0.443316239017411	0.463106292293792	0.45939541279009	0.345045441890767	0.302296180560899	NA	NA	0.467564489914988	0.427237065244732	NA	NA	p.Val87Pro	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.59	-4.469	2.879	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87Q	87	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val87Gln	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.59	-3.351	1.761	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87R	87	V	R	missense	low	0.428691188897887	0.10206975788511	6	0.0416698041646567	0.347019873492323	0.510362504303451	0.588921536974344	0.502201341172779	0.421803450967314	0.349757135061696	NA	NA	0.398295996929483	0.311167672281707	0.55532029501602	0.598719976801872	0.565909454774741	0.544731135257299	0.508973278667911	NA	NA	0.567663226489777	0.541640424466851	NA	NA	p.Val87Arg	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.59	-3.453	1.863	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87S	87	V	S	missense	wt-like	0.925999152845103	0.0793148807779904	6	0.0323801644859597	0.86253519663914	0.989463109051067	0.815067253891392	0.878963463397069	1.04283275090238	0.928668995181584	NA	NA	0.980861594814534	0.909600858883663	0.681864429178168	0.646888736313156	0.647369859922797	0.730552419068902	0.700711128588988	NA	NA	0.687499926155981	0.676228932200356	NA	NA	p.Val87Ser	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.59	-3.255	1.665	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87T	87	V	T	missense	wt-like	1.02604452387964	0.266743338863938	6	0.108897512083826	0.812609322189327	1.23947972556995	1.51233349514261	1.1078761449118	0.920061124171918	0.929159123206809	NA	NA	0.955808504564145	0.731028751280563	0.69534039114087	0.795405587961011	0.696863475867069	0.693817306414671	0.700873460888974	NA	NA	0.682346378361628	0.636067801395433	NA	NA	p.Val87Thr	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.59	-2.764	1.174	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87V	87	V	V	synonymous	wt-like	1.26503355574462	0.081558697826399	6	0.0332961989600862	1.19977420496077	1.33029290652847	1.27564870370479	1.18831451843473	1.15872912076914	1.37539055799921	NA	NA	1.32652337421358	1.26559505934627	0.757448431003053	0.744992018541393	0.714255198946725	0.765230351720385	0.848667040133617	NA	NA	0.758604308210656	0.756292553795449	NA	NA	p.Val87=	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87W	87	V	W	missense	possibly_low	0.579231290005809	0.224395286585559	6	0.0916089921367031	0.399680964757858	0.75878161525376	0.76630309417879	0.912477828047757	0.52665373313596	0.561549886193612	NA	NA	0.328092662114836	0.3803105363639	0.577611885380335	0.636502030281364	0.654616060009491	0.576103912745614	0.579119858015056	NA	NA	0.553222044277351	0.557190756743849	NA	NA	p.Val87Trp	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.59	-5.713	4.123	0.008208818	NA	NA	NA	NA	NA	NA	NA
V87X	87	V	X	nonsense	low	-0.229036402244611	0.0701982415959496	6	0.0286583121251157	-0.285205661867545	-0.172867142621677	-0.297117076795152	-0.27597069337454	-0.165689685649861	-0.123878094203384	NA	NA	-0.281271530071821	-0.230291333372909	0.403827172095377	0.409994842025034	0.397659502165719	0.368944374651763	0.352103456572099	NA	NA	0.427872737776042	0.419865494196491	NA	NA	p.Val87Ter	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V87Y	87	V	Y	missense	possibly_low	0.625725482076044	0.492776428062067	6	0.201175134337228	0.231429464190071	1.02002149996202	0.0556967482633746	0.000985844501819979	0.738064889867319	1.2021526821856	NA	NA	0.764701550192694	0.992751177445463	0.641198005360683	0.4851437527503	0.457540765310267	0.639361302630479	0.791289984796526	NA	NA	0.643034708090886	0.694929561683062	NA	NA	p.Val87Tyr	0	16.3	23	17.9	0.999	10.3	-179.6	-125.7	134.9	4.84848484848485	-5.6	0	1	13.03	0	0	0	0	7	13.484565561111	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.59	-3.834	2.244	0.008208818	NA	NA	NA	NA	NA	NA	NA
G88A	88	G	A	missense	possibly_low	0.615484046431197	0.154084746434593	6	0.0629048343184804	0.492192836713516	0.738775256148877	0.626418305164006	0.912991511053248	0.539384096427648	0.59976095264701	NA	NA	0.490144561877323	0.524204851417945	0.590664155986277	0.606706742299804	0.6547271243211	0.579913028435481	0.591775511197648	NA	NA	0.586556942377542	0.589552800774906	NA	NA	p.Gly88Ala	1	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.593	-1.951	1.358	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88C	88	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly88Cys	1	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.593	-5.242	4.649	0.00274509	NA	NA	NA	NA	1.08e-05	NA	NA
G88D	88	G	D	missense	low	0.181590720805314	0.188143850303139	5	0.0841404877652726	0.0166783951437465	0.346503046466881	0.333904247499635	NA	0.251769527719074	0.0305353171854073	NA	NA	0.355751513752332	-0.0640070021298797	0.493854434411115	0.54440160785203	NA	0.493854434411115	0.403245776393521	NA	NA	0.558911610411753	0.457263085945274	NA	NA	p.Gly88Asp	1	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.593	-3.816	3.223	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88E	88	G	E	missense	low	0.0273154734612779	0.262648249227247	6	0.10722569874035	-0.18284303428695	0.237473981209506	0.396839991472084	0.193634250140746	0.0735409680309501	0.0395184469536719	NA	NA	-0.300193391887186	-0.239447423942598	0.432253095090796	0.557806843898064	0.499193617995739	0.440525775398404	0.406221023760145	NA	NA	0.423980414783189	0.417806275901054	NA	NA	p.Gly88Glu	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.593	-3.933	3.34	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88F	88	G	F	missense	low	0.0334371988715713	0.384113015294396	4	0.192056507647198	-0.342986639113478	0.40986103685662	0.588137519288962	-0.0501540933660039	NA	NA	NA	NA	-0.294249333893412	-0.109985296543261	0.446703104228355	0.598552981999341	0.446483708848845	NA	NA	NA	NA	0.425203137675142	0.446922499607864	NA	NA	p.Gly88Phe	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.593	-4.56	3.967	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88G	88	G	G	synonymous	wt-like	0.945529223815835	0.105478963352533	6	0.0430616064685722	0.861130026020996	1.02992842161067	0.775297574846584	1.01066306774247	0.869048105888458	0.948925724265009	NA	NA	1.05295675356933	1.01628411658315	0.689387800229466	0.638417843599088	0.675844864428236	0.678553445998538	0.707420235706063	NA	NA	0.7023302661528	0.700222154460394	NA	NA	p.Gly88=	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88H	88	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly88His	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.593	-4.991	4.398	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88I	88	G	I	missense	low	0.233009769170812	0.466968160045897	6	0.190638953039793	-0.140635712837605	0.606655251179229	-0.435465322220987	-0.17906813507172	0.472484769558906	0.64457791350043	NA	NA	0.169688089849028	0.725841299409214	0.540266583050221	0.380526835937749	0.418610975770945	0.559895746149151	0.606619062187002	NA	NA	0.52063741995129	0.634901135806132	NA	NA	p.Gly88Ile	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.593	-4.39	3.797	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88K	88	G	K	missense	low	0.0995963492174687	0.175230061022976	6	0.0715373728505084	-0.0406143251181412	0.239807023553079	0.269660825398194	0.30434439782985	-0.119525670474344	-0.0841293246495397	NA	NA	0.12976345163974	0.0974644155609121	0.503001482801687	0.530717837973154	0.523130454935485	0.382757340588652	0.365268402976348	NA	NA	0.512424719277344	0.493578246326031	NA	NA	p.Gly88Lys	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.593	-3.95	3.357	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88L	88	G	L	missense	low	-0.0188277018246809	0.0923011312520843	6	0.0376817790415441	-0.0926826316195035	0.0550272279701417	-0.0909147154815538	-0.137245426248155	0.0421406915992298	0.118642679829606	NA	NA	-0.0419189700613467	-0.00367047058586563	0.443171483712527	0.453915691326005	0.427653537653343	0.431130341593281	0.432427276099049	NA	NA	0.477108773945091	0.47083286102482	NA	NA	p.Gly88Leu	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.593	-3.963	3.37	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88M	88	G	M	missense	low	0.226603668276671	0.356562820337998	6	0.145566161845961	-0.0587007663091414	0.511908102862484	-0.345531851765542	-0.00995490485670913	0.209658077378764	0.407738606860771	NA	NA	0.472711409187804	0.62500067285494	0.50471551166784	0.39968255451354	0.455175246531183	0.481254056673345	0.528176966662336	NA	NA	0.582970854406207	0.612221929921986	NA	NA	p.Gly88Met	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.593	-5.146	4.553	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88N	88	G	N	missense	possibly_wt-like	0.800810738079004	0.356198228757654	4	0.178099114378827	0.451742888218023	1.14987858793998	0.514315320545642	1.30200432203185	NA	NA	NA	NA	0.58321363829931	0.803709671439218	0.629057785689865	0.58282894447903	0.738836272563013	NA	NA	NA	NA	0.605701723668924	0.652413847710805	NA	NA	p.Gly88Asn	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.593	-3.825	3.232	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88P	88	G	P	missense	possibly_low	0.691557919826289	0.752111591849777	6	0.307048271610726	0.0897543659539933	1.29336147369858	-0.14477782901829	-0.327337202400199	0.75883647710399	1.23960846649063	NA	NA	1.21879829684385	1.40421930993776	0.691010593160204	0.442442914402126	0.386553458353331	0.645576473166759	0.803695485606731	NA	NA	0.73644471315365	0.787469352543399	NA	NA	p.Gly88Pro	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.593	-4.148	3.555	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88Q	88	G	Q	missense	low	0.185380998952114	0.191100911654651	6	0.0780166204890971	0.0324712325979541	0.338290765306274	0.154534068091197	0.15996736241244	0.192524357880753	0.357741752506946	NA	NA	0.391757979640437	-0.144239526819089	0.499055210456958	0.506195980289381	0.491914440624535	0.476127390743217	0.511617814886391	NA	NA	0.566318323156788	0.439218672614977	NA	NA	p.Gly88Gln	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.593	-4.392	3.799	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88R	88	G	R	missense	low	-0.000297479330634339	0.120785811811779	6	0.0493106011844485	-0.0969444817081714	0.0963495230469027	-0.165637518394409	-0.136953718534203	0.0787776370372243	0.121118684964864	NA	NA	0.0306129657197441	0.0702970732229738	0.440046245778009	0.437999826225457	0.427716608294369	0.44209266533056	0.433247338588233	NA	NA	0.492028961192609	0.487468270899851	NA	NA	p.Gly88Arg	1	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.593	-4.201	3.608	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88S	88	G	S	missense	low	0.402318171874017	0.245106268123404	6	0.100064214943357	0.206195914443763	0.598440429304271	0.684882814783716	0.737631646900672	0.291152709256592	0.305854171672982	NA	NA	0.16333777777582	0.231049910854319	0.521476475048686	0.619159610928972	0.616812257783447	0.505638473191012	0.494432447178343	NA	NA	0.519331128533695	0.523621821563678	NA	NA	p.Gly88Ser	1	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.593	-3.429	2.836	0.00274509	NA	NA	NA	NA	1.22e-05	NA	NA
G88T	88	G	T	missense	low	0.0156587499246	0.310307336795472	6	0.126682439765145	-0.23263426948875	0.26395176933795	0.282932053189282	0.497750486635784	-0.116556043433816	-0.062749814733059	NA	NA	-0.320254560829703	-0.187169621280888	0.424708680741376	0.53354459316712	0.564947127639258	0.383645897552342	0.372349379453326	NA	NA	0.41985373053296	0.429563630949791	NA	NA	p.Gly88Thr	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.593	-3.863	3.27	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88V	88	G	V	missense	low	0.0011170533259937	0.191441793266926	6	0.0781557848245588	-0.152065470113604	0.154299576765591	0.289336739564972	0.169980478927711	-0.192467131808061	-0.00451906361219733	NA	NA	-0.106470264254681	-0.149158438861782	0.45097132359957	0.534908783486448	0.494079394265079	0.360932161020566	0.391635629724466	NA	NA	0.463830245169285	0.438112402029856	NA	NA	p.Gly88Val	1	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.593	-3.909	3.316	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88W	88	G	W	missense	low	0.251353909688739	0.201045694589705	6	0.0820765611213668	0.0904868059159601	0.412221013461519	0.0412775013644034	0.0251275714466094	0.458817758081397	0.441921696847496	NA	NA	0.154954331460358	0.386024598932173	0.528552574763114	0.482072470898585	0.462760490813155	0.555806371269602	0.539498538440734	NA	NA	0.517606611085495	0.558475857856851	NA	NA	p.Gly88Trp	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.593	-5.445	4.852	0.00274509	NA	NA	NA	NA	NA	NA	NA
G88X	88	G	X	nonsense	low	-0.0703504698871187	0.124413166488712	6	0.0507914625302126	-0.169899907168451	0.0291989673942136	-0.177211665614257	0.0831054533829804	-0.0966594048661593	-0.18837674659219	NA	NA	-0.12877929879845	0.0858188431653639	0.44738785533189	0.43553454710551	0.475295991261768	0.389599270320042	0.330741253128426	NA	NA	0.45924116355827	0.490959139890241	NA	NA	p.Gly88Ter	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G88Y	88	G	Y	missense	possibly_low	0.635647733955944	0.797199095935988	4	0.398599547967994	-0.14559302431527	1.41688849222716	-0.113315912438752	0.0832541597650203	NA	NA	NA	NA	0.975095976618887	1.59755671187862	0.580821026283877	0.449144263930845	0.475328143331773	NA	NA	NA	NA	0.68631390923598	0.830951219857688	NA	NA	p.Gly88Tyr	0	16.9	19.4	16.9	0.894	17.9	-146.7	-125.4	160.6	0	-6	0	1	12.68	0	0	0	0	8	9.74129444492927	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.593	-4.656	4.063	0.00274509	NA	NA	NA	NA	NA	NA	NA
V89A	89	V	A	missense	wt-like	1.03901178384648	0.229937037760234	8	0.0812950193231043	0.879676473850708	1.19834709384225	0.903632817177533	0.851110665235925	1.04303341620165	1.04444641480811	1.50810845322598	1.22990995948834	0.864151685513319	0.867700859120983	0.691561389020673	0.66575309234461	0.64134775714527	0.730612461137016	0.739057058319989	0.726494018770398	0.716317217686583	0.663492105577878	0.666805560354763	NA	NA	p.Val89Ala	1	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.329	-1.986	0.657	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89C	89	V	C	missense	wt-like	1.10961441456375	0.228564976077222	6	0.0933112607434395	0.926727704154586	1.29250112497292	1.08453315835231	1.35364884857506	0.910239707443575	1.11535358215849	NA	NA	1.38061398483334	0.813297206019756	0.727143534758003	0.704284642481167	0.750002427034839	0.690878591179334	0.762541786736057	NA	NA	0.769731021293498	0.654570098401655	NA	NA	p.Val89Cys	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.329	-2.741	1.412	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89D	89	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val89Asp	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.329	-4.286	2.957	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89E	89	V	E	missense	low	-0.122274083313951	0.394753259261065	6	0.161157343248368	-0.438136671924911	0.193588505297009	0.531143825266733	0.167707683266712	-0.351544673080324	-0.293966111047327	NA	NA	-0.253950228257869	-0.533034996031628	0.392635432709754	0.58641339528312	0.493587989093373	0.313333774039636	0.295769646723665	NA	NA	0.433492868198873	0.351777997220635	NA	NA	p.Val89Glu	1	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.329	-4.156	2.827	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89F	89	V	F	missense	wt-like	0.84973182760106	0.044719071130313	6	0.0182564843400822	0.813949775810179	0.88551387939194	0.805745687711652	0.876451114173212	0.886510220512849	0.782404319138366	NA	NA	0.860962098989676	0.886317525080603	0.657551846457426	0.64490325418375	0.646826660451363	0.683778372677374	0.652267701470183	NA	NA	0.66283599144467	0.670992476031525	NA	NA	p.Val89Phe	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.329	-4.352	3.023	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89G	89	V	G	missense	low	0.35117159969899	0.134414815849847	6	0.0548746187837152	0.243619323217544	0.458723876180437	0.529988668202848	0.494442273445481	0.319600760526011	0.325898350064111	NA	NA	0.241156528347569	0.195943017607921	0.525532534910113	0.586167348249523	0.564231853011312	0.51415055693549	0.501071156683023	NA	NA	0.535338840411158	0.515726229409069	NA	NA	p.Val89Gly	1	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.329	-3.903	2.574	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89H	89	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val89His	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.329	-5.276	3.947	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89I	89	V	I	missense	possibly_wt-like	0.913494244472916	0.309421176433705	4	0.154710588216853	0.610267063540878	1.21672142540495	0.944164742232015	0.600714233037339	1.32718382065476	NA	NA	NA	0.781914181967555	NA	0.660480888156063	0.674386342521065	0.587209101448927	0.815634525243464	NA	NA	NA	0.646575433791061	NA	NA	NA	p.Val89Ile	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.329	-1.936	0.607	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89K	89	V	K	missense	low	-0.0409418670828312	0.143507776846263	6	0.0585868045657563	-0.155769894001	0.073886159835338	-0.256159518996342	-0.00172295086067801	-0.132185345071319	-0.0137756957332599	NA	NA	0.17192401304788	-0.0137317048832683	0.437836921662008	0.418718751452442	0.456955091871575	0.378969376016782	0.388569797319451	NA	NA	0.521097360699303	0.468570074567849	NA	NA	p.Val89Lys	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.329	-4.141	2.812	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89L	89	V	L	missense	possibly_low	0.697561025754015	0.197150608828575	6	0.0804863990181757	0.53981058243307	0.855311469074959	0.752764803772921	1.00836538794842	0.710249357645559	0.731458522902357	NA	NA	0.555560535314855	0.426967546939976	0.632328434576844	0.633618391078976	0.675348079014089	0.631038478074712	0.63539425646806	NA	NA	0.600013340061623	0.567683987348917	NA	NA	p.Val89Leu	1	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.329	-2.355	1.026	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89M	89	V	M	missense	possibly_low	0.69448919448488	0.0757489381134271	6	0.0309243744892596	0.633878534241502	0.755099854728258	0.725829660848863	0.766107000855574	0.705172934665866	0.760546712530448	NA	NA	0.573378635693326	0.635900222315205	0.625425101610538	0.627881238770286	0.62296896445079	0.629519536157871	0.645028377517561	NA	NA	0.603678613725961	0.614673254697529	NA	NA	p.Val89Met	1	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.329	-4.649	3.32	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89N	89	V	N	missense	wt-like	1.12277366373173	0.09375242631896	6	0.0382742677715547	1.04775747736484	1.19778985009862	1.03033023631721	1.13594582302712	1.00141988389269	1.19216049323553	NA	NA	1.2478708662768	1.12891467964102	0.721857001212981	0.692739486765151	0.702932470643269	0.718161067944464	0.787980533121286	NA	NA	0.742425088212374	0.725552934481499	NA	NA	p.Val89Asn	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.329	-3.195	1.866	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89P	89	V	P	missense	low	0.0953802232365073	0.137058960419123	6	0.0559540862838614	-0.0142877706677076	0.205048217140722	0.165434160716581	0.231833630088814	0.114295400718741	0.104091246247506	NA	NA	-0.167555981358653	0.124182883006054	0.476153691110485	0.508517686609892	0.50745277353028	0.452720113095273	0.4276077849459	NA	NA	0.451264603186547	0.499587269125697	NA	NA	p.Val89Pro	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.329	-4.4	3.071	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89Q	89	V	Q	missense	possibly_low	0.673467939538265	0.212967162088652	6	0.0869434798476325	0.503061850346321	0.843874028730208	0.861059877893865	0.970677455812304	0.621970477521316	0.67699475902473	NA	NA	0.404181016452485	0.505924050524889	0.610989879828804	0.656685108648081	0.667199504516006	0.604624112697985	0.617355646959624	NA	NA	0.568873804868706	0.585441421647789	NA	NA	p.Val89Gln	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.329	-4.583	3.254	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89R	89	V	R	missense	low	0.251785131719835	0.0924422613096197	6	0.0377393951462659	0.177817276434828	0.325752987004842	0.366032331443407	0.362004265180585	0.187540922752015	0.144619362331259	NA	NA	0.209321624903823	0.241192283707918	0.527346547715491	0.551244850209848	0.535597196887793	0.474636272186474	0.441030853938891	NA	NA	0.528790239229178	0.525902856201803	NA	NA	p.Val89Arg	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.329	-4.484	3.155	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89S	89	V	S	missense	possibly_wt-like	0.757628053222263	0.0718348303640197	6	0.0293264466918726	0.700149273911659	0.815106832532867	0.870626659794488	0.823527300949527	0.708711309219888	0.693342344691219	NA	NA	0.72656574544982	0.722994959228635	0.634725484616443	0.658722821424384	0.635383909142581	0.630578270910489	0.622770030638763	NA	NA	0.63518997953827	0.634260989694615	NA	NA	p.Val89Ser	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.329	-2.88	1.551	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89T	89	V	T	missense	possibly_wt-like	0.818786577560517	0.192769053134264	6	0.0786976363964008	0.664542044555143	0.973031110565891	0.457480437941705	1.03839343339436	0.888205100587948	0.860568808116575	NA	NA	0.834523322995689	0.833548362326822	0.668640348142862	0.570723184399545	0.681840495856285	0.684285506224044	0.67815608291353	NA	NA	0.65739740106131	0.659124613372194	NA	NA	p.Val89Thr	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.329	-3.759	2.43	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89V	89	V	V	synonymous	possibly_wt-like	0.845653493797689	0.46247014395399	6	0.188802645659793	0.475607108118617	1.21569987947676	0.303072491526968	0.210266225146567	1.05156055271535	1.17972173602457	NA	NA	1.081688472746	1.24761148462668	0.720702217449149	0.537834481757385	0.50278964674297	0.73316390831411	0.783860768563646	NA	NA	0.708240526584188	0.752248021273837	NA	NA	p.Val89=	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89W	89	V	W	missense	possibly_low	0.597571489801587	0.187202396709175	6	0.0764250584272586	0.44778112776779	0.747361851835383	0.741196410572079	0.885132188952433	0.540956802124316	0.572920120374943	NA	NA	0.364004328271978	0.48121908851377	0.581634664591276	0.631154337557999	0.648703610991032	0.580383605575147	0.582885723607404	NA	NA	0.560609256236673	0.579885239194791	NA	NA	p.Val89Trp	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.329	-5.788	4.459	0.007303087	NA	NA	NA	NA	NA	NA	NA
V89X	89	V	X	nonsense	low	0.413691426775002	0.334837625493918	6	0.136696888190871	0.145770449122196	0.681612404427808	0.0482735822787067	-0.0761942411103268	0.612303005699608	0.592661786021683	NA	NA	0.625375858794925	0.679728568965418	0.595577849903998	0.483562627527137	0.440853522425527	0.601731460088342	0.589424239719655	NA	NA	0.614374706373595	0.624530314606879	NA	NA	p.Val89Ter	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V89Y	89	V	Y	missense	low	0.461256234918716	0.144869596452877	6	0.0591427650920766	0.345338545392134	0.577173924445299	0.444718324676436	0.309954258236708	0.675178093575045	0.557914014780628	NA	NA	0.299118515427874	0.480654202815606	0.572960256648188	0.568004869973293	0.524343372781018	0.620544629692421	0.577915643323081	NA	NA	0.547261915276917	0.579758195566767	NA	NA	p.Val89Tyr	0	16.2	17.4	13.8	0.999	25.2	162.6	-129	130.5	1.21212121212121	-4.3	0	1	11.97	0	0	0	0	8	7.75764955084457	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.329	-4.513	3.184	0.007303087	NA	NA	NA	NA	NA	NA	NA
E90A	90	E	A	missense	possibly_low	0.67814716264342	0.307136257235372	6	0.12538785195581	0.432391488711192	0.923902836575647	0.725968395004634	1.19573918544904	0.729066996965098	0.65248261603278	NA	NA	0.273774210101413	0.491851572307555	0.61857395962583	0.627910788974802	0.715860499340258	0.636668998079204	0.609237130276857	NA	NA	0.542048463063669	0.582276500507406	NA	NA	p.Glu90Ala	1	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-0.783	-3.455	2.672	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90C	90	E	C	missense	possibly_wt-like	0.737108099371648	0.27586958945006	6	0.112623288283955	0.516370510514625	0.957845688228671	0.556952785553486	0.952300316843273	0.508802519865062	1.04241571747668	NA	NA	0.955081313150038	0.407095943341353	0.627568411427777	0.591910672075432	0.663226150780122	0.570762561914116	0.738384483499896	NA	NA	0.682196791397673	0.563214834343221	NA	NA	p.Glu90Cys	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-0.783	-5.572	4.789	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90D	90	E	D	missense	wt-like	1.04081287847016	0.187009999643632	6	0.0763465126541606	0.891176463322775	1.19044929361755	0.802600035454903	0.926273424821755	1.14105046482554	1.26728937761099	NA	NA	1.20100684979568	0.906657118312093	0.704175901405811	0.644233234122672	0.657598830400088	0.759940632630083	0.812863510564754	NA	NA	0.732784922214607	0.675566880597015	NA	NA	p.Glu90Asp	1	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-0.783	-1.632	0.849	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90E	90	E	E	synonymous	wt-like	0.920900637234496	0.125007769344632	6	0.0510342081296468	0.820875427320867	1.02092584714812	0.937085853964976	1.09417716216351	1.03233807524516	0.775502881626229	NA	NA	0.876307430248221	0.809992420158879	0.66943557599071	0.672878548028246	0.693901594565935	0.727412254661175	0.649981918640189	NA	NA	0.665992603953175	0.653826847179376	NA	NA	p.Glu90=	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90F	90	E	F	missense	possibly_low	0.699774397240764	0.243972033307855	6	0.0996011655189244	0.504559700005459	0.894989094476068	0.92473576161298	0.968682227973174	0.499028088408968	0.363386969362608	NA	NA	0.82215694315023	0.620656392936622	0.633049234462731	0.670247993549676	0.666768112774239	0.567837905377154	0.513487532570217	NA	NA	0.654853573974921	0.611244894950541	NA	NA	p.Glu90Phe	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-0.783	-4.616	3.833	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90G	90	E	G	missense	possibly_wt-like	0.762012493827842	0.0908537753683624	6	0.0370908984763218	0.68931566866002	0.834709318995664	0.781256035329291	0.912550592802479	0.707525904689804	0.642084227031677	NA	NA	0.743380373127251	0.78527782998655	0.639167911064049	0.639686988352134	0.654631792605871	0.630223580090523	0.605793143571694	NA	NA	0.638648833775964	0.648268499338698	NA	NA	p.Glu90Gly	1	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-0.783	-3.618	2.835	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90H	90	E	H	missense	possibly_wt-like	0.765988387087862	0.247793989959385	5	0.110816841193017	0.548791369469054	0.98318540470667	0.343288784814312	0.806170369101632	0.981230235622894	NA	NA	NA	0.899617547865778	0.799634998034696	0.651497447642604	0.546400502755713	0.631631136193672	0.712120022277874	NA	NA	NA	0.670787613432382	0.651497447642604	NA	NA	p.Glu90His	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-0.783	-4.608	3.825	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90I	90	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu90Ile	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-0.783	-4.334	3.551	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90K	90	E	K	missense	possibly_low	0.677755773200306	0.325027525509624	4	0.162513762754812	0.359234651208788	0.996276895191825	0.952588128149468	0.784696898344544	NA	NA	NA	NA	0.767122449182205	0.206615617125007	0.63526050919022	0.676180513359495	0.626988319082758	NA	NA	NA	NA	0.643532699297682	0.518126512807117	NA	NA	p.Glu90Lys	1	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-0.783	-3.43	2.647	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90L	90	E	L	missense	possibly_low	0.579905819649483	0.213188571929882	6	0.0870338700368066	0.409322568942202	0.750489070356763	0.802499425740135	0.896928495687895	0.404902285016349	0.42945601494141	NA	NA	0.450449345351081	0.495199351160025	0.580710427912494	0.644211804377191	0.65125411134454	0.539674052837437	0.535369856319801	NA	NA	0.57839143490798	0.583029420917008	NA	NA	p.Glu90Leu	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-0.783	-3.961	3.178	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90M	90	E	M	missense	possibly_wt-like	0.77606650272017	0.111971613135219	6	0.0457122196429341	0.686472198566635	0.865660806873705	0.849089865641217	0.948892017814368	0.693405779473057	0.633115619154101	NA	NA	0.768651261997167	0.76324447224111	0.643580174241687	0.654135510763119	0.662489236415904	0.625998626782152	0.602822705911502	NA	NA	0.643847183851555	0.643313164631819	NA	NA	p.Glu90Met	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-0.783	-5.083	4.3	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90N	90	E	N	missense	possibly_wt-like	0.86178277667438	0.17749122468704	6	0.0724604890508216	0.719762827832611	1.00380272551615	0.740017094805532	1.19051703818254	0.798591971802999	0.88000103997122	NA	NA	0.688112655253961	0.873456860030024	0.662786003546465	0.630903144750454	0.714731409638884	0.657471913630369	0.684592113355549	NA	NA	0.627279983757936	0.66810009346256	NA	NA	p.Glu90Asn	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-0.783	-3.708	2.925	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90P	90	E	P	missense	possibly_low	0.56855295882001	0.26526987326193	6	0.108295972270749	0.356296753498595	0.780809164141426	0.842530417645799	0.914196501312565	0.462175765993823	0.569319338414466	NA	NA	0.228218726202963	0.394877003350447	0.571079953683091	0.652738356409168	0.654987657397365	0.556811137617022	0.581693130677984	NA	NA	0.532677468858199	0.560466776688198	NA	NA	p.Glu90Pro	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-0.783	-3.978	3.195	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90Q	90	E	Q	missense	low	-0.116909756838373	0.538203974754452	5	0.240692134662307	-0.58865767213856	0.354838158461813	0.208561130661225	0.670676628080921	-0.501015176537711	-0.383385463270068	NA	NA	NA	-0.579385903126233	0.341353609740756	0.51770367815567	0.602335794683725	0.268609956906817	0.266153610989014	NA	NA	NA	0.341353609740756	NA	NA	p.Glu90Gln	1	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-0.783	-3.648	2.865	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90R	90	E	R	missense	possibly_low	0.562150079456146	0.200606846784708	6	0.0818974022552031	0.401634120608559	0.722666038303734	0.737889545210814	0.868566479001772	0.463216286783931	0.506773857943156	NA	NA	0.328069143443547	0.46838516435366	0.568988348014342	0.630449979303974	0.645121909528636	0.557122477048303	0.560977825337088	NA	NA	0.553217206367323	0.576998870691596	NA	NA	p.Glu90Arg	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-0.783	-3.906	3.123	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90S	90	E	S	missense	possibly_wt-like	0.732738733488482	0.120751910791669	6	0.0492967611509437	0.636118857078159	0.829358609898805	0.70066216556368	0.97122815198161	0.672034984599685	0.737011796966996	NA	NA	0.662671151837579	0.652824149981343	0.62228356531929	0.622520593234213	0.667318571509259	0.619604164331089	0.637233522343449	NA	NA	0.622046537404368	0.618479471031401	NA	NA	p.Glu90Ser	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-0.783	-3.484	2.701	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90T	90	E	T	missense	possibly_low	0.601468471476099	0.204606851877524	6	0.0835303974961921	0.437751900769248	0.76518504218295	0.750301491266777	0.915921474432483	0.487522117048792	0.590087873763084	NA	NA	0.337445777729865	0.527532094615592	0.589436426348737	0.633093708545399	0.65536061688806	0.564395146122685	0.588571750012073	NA	NA	0.555146027620979	0.590301102685401	NA	NA	p.Glu90Thr	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-0.783	-3.745	2.962	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90V	90	E	V	missense	possibly_wt-like	0.773049750723321	0.137552111162031	6	0.0561554142315943	0.662987161292468	0.883112340154174	0.760652413770658	1.01071836125809	0.705841322717571	0.60086023171044	NA	NA	0.73711966163874	0.823106513244423	0.63632970797945	0.635298442305589	0.675856819537093	0.629719527890734	0.592139596680439	NA	NA	0.637360973653311	0.656776226087795	NA	NA	p.Glu90Val	1	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-0.783	-3.906	3.123	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90W	90	E	W	missense	wt-like	0.8996428418716	0.0601184750012472	6	0.0245432646445536	0.851538927105239	0.94774675663796	0.959488968176174	0.973079736319914	0.853738281604878	0.817632443772644	NA	NA	0.908122967295833	0.885794654060155	0.671706051467892	0.677650383796149	0.667718905835528	0.673972516880375	0.663935392770771	NA	NA	0.672537221369196	0.670874881566588	NA	NA	p.Glu90Trp	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-0.783	-5.7	4.917	0.003483876	NA	NA	NA	NA	NA	NA	NA
E90X	90	E	X	nonsense	low	-0.230693785866002	0.198823439543225	6	0.0811693292976669	-0.389782747938701	-0.0716048237933029	0.0494675865020791	-0.260074012899886	-0.132847658673755	-0.135115629191048	NA	NA	-0.431210301804575	-0.474382699128826	0.387900386714458	0.483816948957917	0.401096551581222	0.378771201850276	0.348381541466575	NA	NA	0.39702957157864	0.364968985441249	NA	NA	p.Glu90Ter	1	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E90Y	90	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu90Tyr	0	15.3	13.7	14	0.971	32.8	-151.3	-150.4	124.1	7.47663551401869	-3.3	0	0	11.1	3	1156	0	0	8	5.61525836927554	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-0.783	-4.54	3.757	0.003483876	NA	NA	NA	NA	NA	NA	NA
I91A	91	I	A	missense	low	0.448042603836029	0.268198835824578	6	0.109491716229782	0.233442783420177	0.662642424251881	0.699161628305125	0.849136085885086	0.302998307599986	0.208926700449372	NA	NA	0.210151034689108	0.417881866087497	0.54730072866684	0.622200980644019	0.640920829849695	0.509182853934266	0.462329693355243	NA	NA	0.528960853030783	0.565640604302897	NA	NA	p.Ile91Ala	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.909	-2.911	1.002	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91C	91	I	C	missense	possibly_wt-like	0.850730451176709	0.331811917208912	6	0.135461647956075	0.585230499896358	1.11623040245706	1.09736726525133	1.08359565521201	1.00767290925645	0.22677242362019	NA	NA	0.741028757651667	0.947945696068604	0.68823324547677	0.707018291462845	0.691613748223375	0.720032066947121	0.468240265977387	NA	NA	0.638165094539557	0.684852742730166	NA	NA	p.Ile91Cys	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.909	-3.125	1.216	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91D	91	I	D	missense	possibly_low	0.594480084409021	0.161660393980357	6	0.0659975794781955	0.465127205564938	0.723832963253104	0.835078823183964	0.765481808719573	0.507529214482271	0.486666566111742	NA	NA	0.506652359054918	0.465471734901655	0.583148158064129	0.65115117595534	0.622833790552752	0.570381569840249	0.554318212416578	NA	NA	0.589952680024433	0.576343636103824	NA	NA	p.Ile91Asp	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.909	-4.391	2.482	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91E	91	I	E	missense	possibly_low	0.556873231402324	0.238778650782615	6	0.0974809759812705	0.36581402930122	0.747932433503428	0.522205837883242	1.00586144306511	0.448340429700372	0.558579701059253	NA	NA	0.295364057719377	0.510887918986586	0.581322868080953	0.584509614965458	0.674806696659996	0.552671397427174	0.578136121196447	NA	NA	0.546489604274592	0.586557802997959	NA	NA	p.Ile91Glu	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.909	-4.296	2.387	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91F	91	I	F	missense	possibly_low	0.652880449408793	0.263833443957049	6	0.107709552462659	0.441773605791054	0.863987293026532	0.522056989960607	0.536462053476702	0.415413858315782	0.703341510816358	NA	NA	1.15649176294462	0.583516520938695	0.593684996706215	0.584477910541041	0.573317024008246	0.542819273273227	0.626081793181407	NA	NA	0.723627942961193	0.602892082871389	NA	NA	p.Ile91Phe	1	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.909	-2.365	0.456	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91G	91	I	G	missense	possibly_wt-like	0.774819813313033	0.101474107801598	6	0.0414266310363481	0.693625108480961	0.856014518145104	0.625363130281752	0.79923962400367	0.735858053699506	0.725214717358213	NA	NA	0.851962066948152	0.911281287586904	0.636013634016289	0.606481991347902	0.630132627531695	0.638700984140018	0.63332628389256	NA	NA	0.660984639183805	0.676606863098216	NA	NA	p.Ile91Gly	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.909	-2.476	0.567	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91H	91	I	H	missense	possibly_wt-like	0.763266814993672	0.221619865650109	6	0.090475931284488	0.585937248208355	0.940596381778989	1.00207817504227	1.04475162654856	0.757037739715469	0.710749738883875	NA	NA	0.531715858012101	0.533267751759751	0.636786845479824	0.686721832467724	0.683215212049338	0.645038263953747	0.628535427005901	NA	NA	0.595108368942591	0.591591060450422	NA	NA	p.Ile91His	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.909	-5.224	3.315	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91I	91	I	I	synonymous	wt-like	0.908329573009157	0.119841696846109	6	0.0489251678637127	0.812438006058703	1.00422113995961	0.715204896924459	0.875857346064804	0.900952681179835	1.07014032027168	NA	NA	0.992332937669165	0.895489255944995	0.680577492720393	0.625618177124389	0.646698280797937	0.68809977358844	0.747566979309758	NA	NA	0.689859639591565	0.673055211852346	NA	NA	p.Ile91=	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91K	91	I	K	missense	wt-like	0.872183410731469	0.122478047146325	6	0.0500014533668396	0.774182362957804	0.970184458505133	0.903418464645246	0.865847146310821	0.761974728055933	0.783582779674408	NA	NA	0.819728984266311	1.09854836143609	0.653506071337678	0.665707435518917	0.644533957795512	0.6465154849346	0.652658012163335	NA	NA	0.654354130512021	0.718723504656979	NA	NA	p.Ile91Lys	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.909	-4.232	2.323	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91L	91	I	L	missense	possibly_wt-like	0.780165882329436	0.119390089933431	6	0.0487408001136502	0.684635669529016	0.875696095129856	0.693982216901157	0.83771508448912	0.771761332675267	0.744293669566403	NA	NA	0.648521885570193	0.984721104774479	0.639048390837677	0.621097772386402	0.638451474927764	0.649443783864636	0.63964530674759	NA	NA	0.619135961533878	0.693123586476513	NA	NA	p.Ile91Leu	1	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.909	-1.449	-0.46	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91M	91	I	M	missense	possibly_low	0.654802726783889	0.115213607525479	6	0.0470357583104513	0.562614334509874	0.746991119057904	0.723799703834572	0.765379282729405	0.680517862022342	0.455371106674295	NA	NA	0.718701320877211	0.585047084565507	0.62247699587556	0.627448860423383	0.622811623226992	0.622142368524127	0.543953035058516	NA	NA	0.633572227496308	0.603236308892164	NA	NA	p.Ile91Met	1	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.909	-4.577	2.668	0.005405517	NA	NA	NA	NA	8.13e-06	NA	NA
I91N	91	I	N	missense	possibly_low	0.366102224739779	0.583434638607593	5	0.26091990247092	-0.145291386952928	0.877495836432487	0.905361128884604	1.07423823151496	0.0202178081784885	NA	NA	NA	-0.231844267047273	0.0625382221681159	0.485723293835445	0.666121220612142	0.689590563087343	0.424570685965889	NA	NA	NA	0.438040176594776	0.485723293835445	NA	NA	p.Ile91Asn	1	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.909	-4.486	2.577	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91P	91	I	P	missense	possibly_low	0.628547050803012	0.230003289162748	6	0.0938984496017575	0.444509471379418	0.812584630226606	0.844792275405283	0.980064343572408	0.570770528550906	0.495210131566944	NA	NA	0.407572573256851	0.472872452465679	0.583656194116438	0.653220129329525	0.669229060129248	0.589304319815806	0.557147874380493	NA	NA	0.56957146531354	0.578008068417071	NA	NA	p.Ile91Pro	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.909	-4.534	2.625	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91Q	91	I	Q	missense	wt-like	0.917594084929974	0.0972625065193574	6	0.039707252012758	0.839769301059913	0.995418868800035	1.04725226744829	0.825948705329233	0.916304030974093	0.788210502939308	NA	NA	0.986892582113807	0.940956420775112	0.686010687619289	0.696343858579517	0.635907445268329	0.692693127762403	0.654190732029634	NA	NA	0.68874053084719	0.683280844391387	NA	NA	p.Ile91Gln	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.909	-4.662	2.753	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91R	91	I	R	missense	possibly_low	0.641914671158821	0.101224676632762	6	0.0413248011880823	0.560919549161902	0.72290979315574	0.645016224930199	0.811716853154681	0.667007263739244	0.648345112741215	NA	NA	0.559994563865403	0.519408008522183	0.609267424747989	0.610668076331863	0.6328303513256	0.618099794819005	0.607866773164115	NA	NA	0.600925442234584	0.588473983721262	NA	NA	p.Ile91Arg	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.909	-4.504	2.595	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91S	91	I	S	missense	wt-like	0.865794156755966	0.0523351599130109	6	0.0213657395656396	0.82391807670425	0.907670236807682	0.857887840391739	0.961499002048873	0.820525061362539	0.884214166603314	NA	NA	0.845971018979073	0.824667851150256	0.661893436651548	0.656009468562195	0.66521501478602	0.664034623087612	0.685987517211528	NA	NA	0.659752250215485	0.657127373289385	NA	NA	p.Ile91Ser	1	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.909	-3.976	2.067	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91T	91	I	T	missense	possibly_wt-like	0.740482903219494	0.198126913503072	6	0.0808849737325107	0.581951267813305	0.899014538625683	0.443969119420871	0.789562483198226	0.875482883473967	0.545130383625499	NA	NA	0.927453448991027	0.861299100607375	0.64670305560081	0.567845290175489	0.628040315793901	0.680478827992764	0.5736816551796	NA	NA	0.676513599544838	0.66536579540772	NA	NA	p.Ile91Thr	1	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.909	-3.433	1.524	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91V	91	I	V	missense	wt-like	1.12756708607434	0.116642221494535	6	0.0476189875210511	1.03423558555282	1.22089858659586	1.04385220360702	0.937700531938387	1.13479717547926	1.23101393344978	NA	NA	1.1872582836913	1.23078038828028	0.73920972762094	0.695619649163897	0.660069505450689	0.758069554639895	0.800848942981076	NA	NA	0.729956772400968	0.748462682840913	NA	NA	p.Ile91Val	1	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.909	-2.363	0.454	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91W	91	I	W	missense	wt-like	0.976479570766983	0.0701066278282216	6	0.0286209109610578	0.920383616078582	1.03257552545538	0.847798052573143	0.971598919107916	0.988338050495171	1.05052796523708	NA	NA	0.975481419766187	1.0251330174224	0.694302741089461	0.653860356168737	0.667398735725731	0.714246787125844	0.741071291373007	NA	NA	0.68639319684728	0.702212285331642	NA	NA	p.Ile91Trp	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.909	-4.086	2.177	0.005405517	NA	NA	NA	NA	NA	NA	NA
I91X	91	I	X	nonsense	low	0.24518360171872	0.209932719618191	6	0.0857046738965561	0.0772055275747202	0.41316167586272	0.0864254631794822	0.183333276936054	0.569029306885741	0.439720983221901	NA	NA	0.142520893292931	0.0500716867962121	0.506007708056496	0.491688931226653	0.496966426350996	0.588783320170128	0.538769653565623	NA	NA	0.515048989761995	0.482919551613462	NA	NA	p.Ile91Ter	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I91Y	91	I	Y	missense	wt-like	1.13935735561072	0.210354512202222	4	0.105177256101111	0.933213721659796	1.34550098956164	NA	NA	1.08488275262911	0.867875440644742	NA	NA	1.34076297522539	1.26390825394364	0.749523799614027	NA	NA	0.743134410459579	0.68057606790196	NA	NA	0.76153346639647	0.755913188768476	NA	NA	p.Ile91Tyr	0	13.7	11.5	11.4	0.796	78.6	82.9	-67.6	-28.6	17.2774869109948	-1.3	0	0	13.05	0	0	0	0	6	6.86924365355465	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.909	-3.424	1.515	0.005405517	NA	NA	NA	NA	NA	NA	NA
S92A	92	S	A	missense	possibly_low	0.577168447579485	0.410583811325918	6	0.167620139065943	0.24863901192664	0.905697883232329	0.98923513282672	1.13600154157157	0.347031242743369	0.59660927822091	NA	NA	0.10087354592998	0.293259944184363	0.564172307192711	0.683986280274617	0.702944517648361	0.522358168753054	0.590731664422792	NA	NA	0.506481919073394	0.53761294996263	NA	NA	p.Ser92Ala	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.303	-2.004	0.701	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92C	92	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser92Cys	1	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.303	-3.109	1.806	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92D	92	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser92Asp	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.303	-3.95	2.647	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92E	92	S	E	missense	possibly_low	0.421402165077337	0.403184339187314	5	0.180309517977233	0.068002003772182	0.774802326382491	0.583175704822489	NA	0.289159964618763	-0.049108144985783	NA	NA	1.02133900485787	0.26244429607334	0.530682465178433	0.597496121621734	NA	0.505042214098327	0.376867553301301	NA	NA	0.695826334801186	0.530682465178433	NA	NA	p.Ser92Glu	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.303	-3.886	2.583	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92F	92	S	F	missense	low	0.28606126767436	0.227367776475444	6	0.0928225060526699	0.104132498856375	0.467990036492344	0.603262303728408	0.539522923574015	0.0550137321402748	0.164913713333743	NA	NA	0.205960612994455	0.147694320275262	0.516486944062642	0.601774542479263	0.573978820148369	0.434982148456735	0.447752421581251	NA	NA	0.528098862024242	0.504875026101042	NA	NA	p.Ser92Phe	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.303	-4.467	3.164	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92G	92	S	G	missense	possibly_low	0.654969199712837	0.09817043000539	6	0.0400779102238028	0.576417939098554	0.73352046032712	0.737671958273331	0.805652206584238	0.604613900904749	0.650486299137295	NA	NA	0.574259370722676	0.557131462654733	0.606217863890503	0.630403633553953	0.631519103358868	0.599430764574471	0.60857594239029	NA	NA	0.603859785390715	0.596958044284619	NA	NA	p.Ser92Gly	1	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.303	-3.587	2.284	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92H	92	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser92His	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.303	-3.972	2.669	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92I	92	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser92Ile	1	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.303	-2.842	1.539	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92K	92	S	K	missense	possibly_low	0.694817949921352	0.126822993294848	6	0.0517752702041317	0.593340285031424	0.79629561481128	0.739123924513971	0.71979020531083	0.74483633557292	0.864718416501246	NA	NA	0.502010272803784	0.59842854482536	0.621833814351472	0.63071290057708	0.612954728125864	0.641387420777251	0.679530449279987	NA	NA	0.58899777932669	0.606245819073067	NA	NA	p.Ser92Lys	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.303	-3.897	2.594	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92L	92	S	L	missense	low	0.467874549699724	0.185391894109909	6	0.0756859238362278	0.319532864844076	0.616216234555372	0.65617178188939	0.695911502152789	0.449718776119705	0.359827235972447	NA	NA	0.199719213203311	0.445898788860701	0.562512735489578	0.613044196241217	0.607791871461345	0.553083819355099	0.512308535086247	NA	NA	0.526814974415734	0.571941651624056	NA	NA	p.Ser92Leu	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.303	-3.547	2.244	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92M	92	S	M	missense	wt-like	0.853920425917341	0.113979578431786	5	0.0509732170840486	0.754014756256464	0.953826095578219	0.724973697851526	0.837815286129557	0.768892757686824	NA	NA	NA	0.942685280406474	0.995235107512325	0.648585463191009	0.627698919704812	0.638473139701755	0.648585463191009	NA	NA	NA	0.679646864559673	0.695488201224615	NA	NA	p.Ser92Met	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.303	-3.926	2.623	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92N	92	S	N	missense	possibly_low	0.720086822053557	0.0935956449098624	6	0.0382102620293141	0.645196084636263	0.794977559470851	0.701234113056845	0.835525299085038	0.599756361980022	0.627087936859508	NA	NA	0.769064106074162	0.787853115265767	0.630310217448638	0.622642417346679	0.637978017550598	0.597977316050783	0.600826314193196	NA	NA	0.643932107973136	0.648847684802469	NA	NA	p.Ser92Asn	1	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.303	-2.654	1.351	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92P	92	S	P	missense	low	0.322986119516048	0.214115263281375	6	0.0874121901968412	0.151661374920474	0.494310864111622	0.125663914928189	0.202488935306837	0.163587171874779	0.428092981653553	NA	NA	0.696234477239224	0.321849236093708	0.518013259780426	0.500046673180138	0.501108105144367	0.467468950547098	0.534918414416485	NA	NA	0.628950683753823	0.544042723948069	NA	NA	p.Ser92Pro	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.303	-4.245	2.942	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92Q	92	S	Q	missense	low	0.371725232093798	0.150617264412252	6	0.0614892407106454	0.251208534864219	0.492241929323377	0.576848437202907	0.543862026281733	0.325403086426107	0.299648708403097	NA	NA	0.263221057420491	0.221368076828451	0.530660994397181	0.59614842140222	0.574916985223093	0.515886699896799	0.49237717371256	NA	NA	0.539877626006097	0.521444362788264	NA	NA	p.Ser92Gln	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.303	-4.33	3.027	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92R	92	S	R	missense	low	0.550641904579486	0.160360832557248	6	0.0654670357488584	0.422328872337127	0.678954936821844	0.667624743428237	0.780591176943048	0.615292077788156	0.443586726585871	NA	NA	0.396442461266284	0.400314241465316	0.584953890050187	0.615483662960187	0.626100613793234	0.602625835302132	0.540050002737949	NA	NA	0.567281944798242	0.561689619572677	NA	NA	p.Ser92Arg	1	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.303	-4.276	2.973	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92S	92	S	S	synonymous	wt-like	0.929958242805706	0.175327549004894	6	0.0715771721524672	0.789669563271647	1.07024692233977	0.666264265659926	0.765796327333773	1.07653020268584	0.946505251112578	NA	NA	1.04791947349627	1.07673393654585	0.703956318852574	0.615193882869122	0.622901793178887	0.74063520220367	0.70661856562464	NA	NA	0.701294072080507	0.713817408272664	NA	NA	p.Ser92=	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92T	92	S	T	missense	possibly_low	0.554267200228223	0.291672823313983	6	0.119074931492702	0.320884623040953	0.787649777415493	0.899198712672914	0.946317357079947	0.347848312590383	0.462289734078059	NA	NA	0.387113561414017	0.282835523534018	0.55580372700354	0.664808633539718	0.661932564462507	0.522602648309738	0.546244511247185	NA	NA	0.565362942759895	0.535268482358347	NA	NA	p.Ser92Thr	1	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.303	-3.232	1.929	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92V	92	S	V	missense	low	0.562836378750556	0.194535660156883	6	0.0794188506933066	0.407178291698111	0.718494465803001	0.749177387405056	0.827281904659235	0.552709467126537	0.528643380862647	NA	NA	0.34107020891693	0.378135923532933	0.576060637643348	0.632854275805663	0.636195698654641	0.583900179268448	0.568221096018249	NA	NA	0.555891591508036	0.556701683105603	NA	NA	p.Ser92Val	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.303	-1.958	0.655	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92W	92	S	W	missense	low	0.510422104901859	0.259132343140172	6	0.10579033609087	0.303076856251366	0.717767353552352	0.852699597727414	0.725970688971057	0.412451418763541	0.55977352417325	NA	NA	0.13242263734638	0.379214762429513	0.567737917801063	0.654904379256985	0.614291021434758	0.541932866913867	0.57853152003491	NA	NA	0.51297172727102	0.556944315567215	NA	NA	p.Ser92Trp	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.303	-5.781	4.478	0.006460359	NA	NA	NA	NA	NA	NA	NA
S92X	92	S	X	nonsense	low	0.0204278291273818	0.376176255520041	5	0.168231135772829	-0.30929913806563	0.350154796320394	0.622856796742207	NA	-0.361935417634651	-0.21745045711215	NA	NA	0.038479180583901	0.0201890430576021	0.47619890089095	0.605948145387133	NA	0.310224707377169	0.321111927615609	NA	NA	0.493647081506627	0.47619890089095	NA	NA	p.Ser92Ter	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S92Y	92	S	Y	missense	possibly_wt-like	0.726790867613437	0.091621467436714	6	0.037404307450829	0.653479772143149	0.800101963083725	0.591319580988198	0.769685987287442	0.725369093241642	0.867913311784898	NA	NA	0.683836857515855	0.72262037486259	0.63028858779167	0.599230757226881	0.623742783440443	0.635562529805685	0.680588610970237	NA	NA	0.626400430466024	0.634176745117317	NA	NA	p.Ser92Tyr	0	12	9.2	14	0.683	55.5	-169	-87.3	113.1	2.7972027972028	-2.4	0	0	13.8	2	3	0	0	7	8.14124399747645	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.303	-4.549	3.246	0.006460359	NA	NA	NA	NA	NA	NA	NA
E93A	93	E	A	missense	wt-like	1.12312223479041	0.134106926505913	6	0.0547489234854021	1.01581631656668	1.23042815301414	1.04824605769541	0.904728971296757	1.1143619557537	1.23574643239959	NA	NA	1.27224512528897	1.16340486630803	0.740374412695846	0.696555534679648	0.652940665979316	0.751955030309444	0.802416364959963	NA	NA	0.747438996976351	0.733309828415342	NA	NA	p.Glu93Ala	1	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.651	-2.556	0.905	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93C	93	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Cys	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.651	-5.596	3.945	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93D	93	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Asp	1	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.651	-2.531	0.88	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93F	93	E	F	missense	possibly_low	0.656281450202694	0.428939346661466	6	0.17511375498723	0.313064797230152	0.999498103175235	1.35458914553632	1.00056977798492	0.560674463402896	0.28231421778247	NA	NA	0.38719961655459	0.352341479954973	0.57583203519588	0.76180623554331	0.673662576389106	0.586283425652769	0.486635923290798	NA	NA	0.565380644738991	0.550900474638729	NA	NA	p.Glu93Phe	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.651	-4.811	3.16	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93G	93	E	G	missense	possibly_low	0.71200080331721	0.293465522740824	6	0.119806797969025	0.477183794194854	0.946817812439567	1.02801442897464	0.981237806106714	0.615703979323553	0.87219031530914	NA	NA	0.307963400244125	0.466894889945095	0.63611592948078	0.692246222649961	0.669482776540299	0.60274908242126	0.682005171100259	NA	NA	0.54908135296626	0.576663705775524	NA	NA	p.Glu93Gly	1	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.651	-3.225	1.574	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93H	93	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93His	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.651	-3.547	1.896	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93I	93	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Ile	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.651	-3.705	2.054	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93K	93	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Lys	1	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.651	-2.879	1.228	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93L	93	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Leu	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.651	-3.088	1.437	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93M	93	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Met	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.651	-5.137	3.486	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93N	93	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Asn	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.651	-3.374	1.723	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93P	93	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Pro	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.651	-2.292	0.641	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93Q	93	E	Q	missense	wt-like	1.11408862194495	0.157238566619229	6	0.0641923760172885	0.988273876869012	1.23990336702089	0.965496945052356	0.86992678212018	1.18153046928395	1.25903648732573	NA	NA	1.19714639779389	1.21139465009359	0.738046804666212	0.678930075480093	0.645416023073001	0.77205285728349	0.810130121342769	NA	NA	0.731990807648292	0.744102801684133	NA	NA	p.Glu93Gln	1	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.651	-2.49	0.839	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93R	93	E	R	missense	wt-like	0.966859217129183	0.177616801283583	6	0.0725117554816825	0.82473878792931	1.10897964632906	1.26502508268565	1.03345645865082	0.84568395827285	0.903934953244745	NA	NA	0.755205553822983	0.997849296098044	0.686646090963546	0.742729200332912	0.680773063810727	0.671562542500829	0.692519118116366	NA	NA	0.641081333450984	0.69607613609949	NA	NA	p.Glu93Arg	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.651	-2.568	0.917	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93S	93	E	S	missense	wt-like	1.08262099395612	0.0772530553426135	6	0.0315384277767322	1.02080681138471	1.14443517652753	1.03452770835965	1.04446737444492	1.04795276908449	1.12431204734173	NA	NA	1.22221616356361	1.02224990094233	0.716824136750201	0.69363354314669	0.683153753399009	0.732084405324362	0.765508865096606	NA	NA	0.737147785681589	0.70156386817604	NA	NA	p.Glu93Ser	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.651	-2.892	1.241	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93T	93	E	T	missense	possibly_wt-like	0.779691423713971	0.076293839715749	6	0.0311468296368785	0.718644759393084	0.840738088034858	0.883615619522229	0.728816576957944	0.786502360098182	0.708960652616662	NA	NA	0.857951617015787	0.712301716073023	0.642855291970111	0.661489453868088	0.614906335912363	0.653854520428458	0.627942874705923	NA	NA	0.662216720026197	0.631856063511765	NA	NA	p.Glu93Thr	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.651	-3.309	1.658	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93V	93	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Val	1	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.651	-4.051	2.4	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93W	93	E	W	missense	possibly_wt-like	0.759630524924593	0.154326842164063	6	0.0630036694861651	0.636145601837844	0.883115448011341	0.692348851362951	1.01810034477186	0.703237706768702	0.661647983756861	NA	NA	0.61028124172193	0.872167021165247	0.624845177236477	0.62074986753604	0.677452891255444	0.628940486936914	0.612272735560168	NA	NA	0.611269667045286	0.66781000679639	NA	NA	p.Glu93Trp	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.651	-5.917	4.266	0.008415349	NA	NA	NA	NA	NA	NA	NA
E93X	93	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Ter	1	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E93Y	93	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu93Tyr	0	8.8	10.4	15.5	0.863	92.1	58.3	-60.2	-34.9	34.5794392523364	-3.6	1	0	14.67	1	26	1	26	5	11.3180651739152	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.651	-4.727	3.076	0.008415349	NA	NA	NA	NA	NA	NA	NA
L94A	94	L	A	missense	possibly_wt-like	0.807040368606673	0.172172066129198	6	0.0702889516628761	0.669276554836359	0.944804182376987	1.03197754203864	1.01631775909579	0.647093785287218	0.760856506474213	NA	NA	0.699901295266373	0.686095323477793	0.637417974650197	0.693090360857391	0.677067475252034	0.612141383305253	0.64513098247142	NA	NA	0.629704966828974	0.625962207102334	NA	NA	p.Leu94Ala	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.032	-3.092	1.06	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94C	94	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu94Cys	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.032	-4.401	2.369	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94D	94	L	D	missense	possibly_low	0.641503344749374	0.272177778001182	6	0.111116112571235	0.423719766007654	0.859286923491094	0.944606715559907	0.585319066297863	0.696756124878111	0.668512378894186	NA	NA	0.147206207118554	0.806619575747625	0.620773675102291	0.674480482296215	0.583880485205564	0.627001100392406	0.614546249812177	NA	NA	0.516012782591166	0.653068289488574	NA	NA	p.Leu94Asp	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.032	-3.364	1.332	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94E	94	L	E	missense	wt-like	1.07606810850292	0.282009730978595	6	0.115129990566186	0.850417473452757	1.30171874355308	0.919026255069424	0.627305284771648	1.35057838314125	1.38550830502608	NA	NA	1.07583060506983	1.09815981793926	0.712835827064239	0.66903187567942	0.592958399798776	0.822634529326856	0.852018077130123	NA	NA	0.707035533477933	0.718636120650545	NA	NA	p.Leu94Glu	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.032	-3.155	1.123	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94F	94	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu94Phe	1	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.032	-3.635	1.603	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94G	94	L	G	missense	wt-like	0.913015240557512	0.0768399005968908	6	0.0313697580580938	0.851531644559913	0.974498836555111	0.910964316519778	1.05114816344767	0.907639419843975	0.842199303260435	NA	NA	0.840645339374292	0.925494900898925	0.675937778749372	0.6673146926857	0.684598218611329	0.690100546117551	0.672072031768851	NA	NA	0.658656730896058	0.679803525729893	NA	NA	p.Leu94Gly	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.032	-3.388	1.356	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94H	94	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu94His	1	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.032	-3.85	1.818	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94I	94	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu94Ile	1	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.032	-2.187	0.155	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94K	94	L	K	missense	wt-like	1.45511222923862	0.422553265511544	6	0.172506648275011	1.11700541152588	1.79321904695136	1.22095815196438	0.82379412058446	1.50309075259241	1.49759781877034	NA	NA	2.10236605314365	1.58286647837647	0.847957941521556	0.733342998298	0.635441598688002	0.868268518401973	0.889142558151418	NA	NA	0.918199084216484	0.82764736464114	NA	NA	p.Leu94Lys	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.032	-2.316	0.284	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94L	94	L	L	synonymous	wt-like	0.984241593603655	0.185450204390405	6	0.0757097289085567	0.835853251663593	1.13262993554372	0.744750028176607	0.827111348482047	1.20017892018429	0.922619278013065	NA	NA	1.17656463703049	1.03422534973543	0.701482301568036	0.631911253736298	0.636158822401762	0.777632753574634	0.698707438835106	NA	NA	0.727757035018806	0.704257164300966	NA	NA	p.Leu94=	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94M	94	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu94Met	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.032	-3.228	1.196	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94N	94	L	N	missense	wt-like	1.15205565207581	0.100451417879446	6	0.0410091196239548	1.07167925457516	1.23243204957645	1.17209391377992	1.16359155296582	1.02334897778098	1.29823468058654	NA	NA	1.05411124195511	1.20095354538648	0.723828778755867	0.722934975674813	0.708909802834003	0.724722581836922	0.823112714746646	NA	NA	0.702567750272112	0.741754581810835	NA	NA	p.Leu94Asn	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.032	-3.855	1.823	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94P	94	L	P	missense	possibly_low	0.684955463665368	0.323395537561546	5	0.144626881121541	0.401491985470792	0.968418941859943	1.02309432564775	0.990316169948859	NA	0.688893848951359	NA	NA	0.385238374375878	0.337234599402997	0.62129667162282	0.691198246693775	0.671445625651289	NA	0.62129667162282	NA	NA	0.564977207270667	0.547502914885161	NA	NA	p.Leu94Pro	1	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.032	-3.749	1.717	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94Q	94	L	Q	missense	wt-like	1.38799568906412	0.296209734698247	6	0.120927117809314	1.15098289340363	1.62500848472461	1.01532355189618	1.05849316536803	1.43918415226638	1.43128087072237	NA	NA	1.72425353855326	1.65943885557851	0.842644013329394	0.68954308144387	0.686186294473928	0.849146704796948	0.867178128144036	NA	NA	0.840419421264359	0.844868605394428	NA	NA	p.Leu94Gln	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.032	-2.718	0.686	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94R	94	L	R	missense	wt-like	1.08281681216323	0.0925552731369157	6	0.0377855320315617	1.00875853024468	1.15687509408178	0.965582801562887	1.01246068942558	1.11022489649861	1.06073356841253	NA	NA	1.11787181385676	1.23002710322302	0.730067525063104	0.67894836281122	0.676233531393334	0.75071716011223	0.744451426666146	NA	NA	0.715683623460063	0.748293267918706	NA	NA	p.Leu94Arg	1	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.032	-2.828	0.796	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94S	94	L	S	missense	possibly_wt-like	0.725615819997219	0.126558937201725	6	0.0516674697555276	0.624349440104073	0.826882199890366	0.804857282573496	0.9023066684466	0.765183954373522	0.556208845474524	NA	NA	0.615810044591946	0.709328124523226	0.637950661680756	0.64471402498219	0.652416935593681	0.647475733596682	0.577350884645593	NA	NA	0.612406969851104	0.631187298379322	NA	NA	p.Leu94Ser	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.032	-2.962	0.93	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94T	94	L	T	missense	wt-like	1.02598280754651	0.281160231612131	6	0.114783183902076	0.801011901067607	1.25095371402542	0.55670876377555	0.900471045960786	1.33381060481316	0.996947821797421	NA	NA	1.26691686984582	1.10104173908635	0.72130480467473	0.591858695736914	0.652020052407785	0.817617358484965	0.723325340375465	NA	NA	0.746342947793899	0.719284268973994	NA	NA	p.Leu94Thr	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.032	-2.849	0.817	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94V	94	L	V	missense	wt-like	1.08016808461961	0.0498803567666562	6	0.020363570377715	1.04025622008264	1.12007994915658	1.00459099820521	1.12583915761599	1.08991718644502	1.10232055999521	NA	NA	1.03414398393989	1.12419662151635	0.712619563434837	0.687257060710292	0.700747290630412	0.744640788588653	0.758225199324904	NA	NA	0.698460383976171	0.724491836239262	NA	NA	p.Leu94Val	1	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.032	-2.6	0.568	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94W	94	L	W	missense	possibly_low	0.456678451575202	0.386073662104655	6	0.157613912547349	0.147760859519953	0.765596043630451	0.903498054710377	0.917850793366421	0.0798409332947287	0.421197354414097	NA	NA	0.0260506108222935	0.391632962843295	0.546185871578508	0.665724388104883	0.655777758348806	0.442410819523385	0.532634555971304	NA	NA	0.491090461638908	0.559737187185711	NA	NA	p.Leu94Trp	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.032	-5.821	3.789	0.008732559	NA	NA	NA	NA	NA	NA	NA
L94X	94	L	X	nonsense	low	-0.190599562328715	0.254031109944039	5	0.113606166046919	-0.413263556202353	0.0320644315449235	-0.36022665497342	-0.265976877800583	0.259010073724514	-0.310101806370679	NA	NA	NA	-0.275702546223406	0.399820282715588	0.396552579507002	0.399820282715588	0.496020914405486	0.290425441946723	NA	NA	NA	0.409652445340325	NA	NA	p.Leu94Ter	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L94Y	94	L	Y	missense	wt-like	1.01330478182706	0.27348373014928	6	0.111649265303124	0.794476242932576	1.23213332072154	1.06632071016897	1.35732099123498	0.59832527880207	0.859598841560556	NA	NA	1.24446377723487	0.953799091960891	0.693287296767824	0.700405413422071	0.750796387497405	0.597549114493472	0.677834826233959	NA	NA	0.741724232707455	0.686169180113576	NA	NA	p.Leu94Tyr	0	9.1	7.6	18.1	0.927	105.1	48	-62	-44.8	34.5549738219895	-3.3	1	0	15.53	0	0	0	0	6	12.0573756834521	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.032	-4.029	1.997	0.008732559	NA	NA	NA	NA	NA	NA	NA
G95A	95	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Ala	1	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.785	-0.942	-0.843	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95C	95	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Cys	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.785	-4.964	3.179	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95D	95	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Asp	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.785	-3.931	2.146	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95E	95	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Glu	1	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.785	-3.819	2.034	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95F	95	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Phe	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.785	-4.513	2.728	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95H	95	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95His	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.785	-5.018	3.233	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95I	95	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Ile	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.785	-4.095	2.31	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95K	95	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Lys	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.785	-3.836	2.051	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95L	95	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Leu	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.785	-3.668	1.883	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95M	95	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Met	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.785	-4.943	3.158	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95N	95	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Asn	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.785	-4.073	2.288	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95P	95	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Pro	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.785	-2.446	0.661	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95Q	95	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Gln	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.785	-4.279	2.494	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95R	95	G	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Arg	1	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.785	-4.135	2.35	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95S	95	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Ser	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.785	-2.459	0.674	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95T	95	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Thr	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.785	-3.634	1.849	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95V	95	G	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Val	1	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.785	-3.631	1.846	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95W	95	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Trp	1	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.785	-5.654	3.869	0.003456475	NA	NA	NA	NA	NA	NA	NA
G95X	95	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Ter	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G95Y	95	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly95Tyr	0	12.5	9	19.3	0.93	111.3	50.7	-62.2	-44.9	0	-2.8	1	0	14.68	0	0	0	0	9	9.35512009587608	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.785	-4.589	2.804	0.003456475	NA	NA	NA	NA	NA	NA	NA
I96A	96	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Ala	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.601	-2.352	0.751	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96C	96	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Cys	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.601	-2.543	0.942	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96D	96	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Asp	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.601	-4.382	2.781	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96E	96	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Glu	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.601	-4.244	2.643	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96F	96	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Phe	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.601	-3.628	2.027	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96G	96	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Gly	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.601	-4.042	2.441	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96H	96	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96His	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.601	-5.339	3.738	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96K	96	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Lys	1	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.601	-4.211	2.61	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96L	96	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Leu	1	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.601	-2.059	0.458	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96M	96	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Met	1	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.601	-4.566	2.965	0.006788075	NA	NA	NA	NA	3.23e-05	NA	NA
I96N	96	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Asn	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.601	-4.548	2.947	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96P	96	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Pro	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.601	-4.442	2.841	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96Q	96	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Gln	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.601	-4.654	3.053	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96R	96	I	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Arg	1	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.601	-4.533	2.932	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96S	96	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Ser	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.601	-3.946	2.345	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96T	96	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Thr	1	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.601	-3.187	1.586	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96V	96	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Val	1	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.601	-1.444	-0.157	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96W	96	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Trp	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.601	-5.704	4.103	0.006788075	NA	NA	NA	NA	NA	NA	NA
I96X	96	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Ter	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I96Y	96	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile96Tyr	0	11.1	12.5	19.5	0.924	111.4	48.1	-56.9	-46.1	0	-4.3	1	0	14.16	0	0	0	0	7	10.6495505329436	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.601	-4.435	2.834	0.006788075	NA	NA	NA	NA	NA	NA	NA
Q97A	97	Q	A	missense	wt-like	0.876950161165166	0.10429812604936	6	0.0425795316582359	0.793495812636441	0.960404509693891	0.788238741019558	1.00537707313297	0.981986312253786	0.862501180481135	NA	NA	0.740047350153477	0.883550309950068	0.672536047720252	0.641174296074419	0.674701970179848	0.712346251749216	0.678796092123829	NA	NA	0.637963214037108	0.670370125260655	NA	NA	p.Gln97Ala	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.213	-2.891	0.678	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97C	97	Q	C	missense	wt-like	1.16223855343858	0.086374839026719	6	0.0352623803717494	1.0931255579008	1.23135154897636	1.12353195025374	1.03545660753952	1.12074477104042	1.19264616032511	NA	NA	1.27787118892142	1.22318064255125	0.747674897806939	0.712591337181998	0.681205519541329	0.753864864404285	0.78814138794211	NA	NA	0.748596306814543	0.746753488799334	NA	NA	p.Gln97Cys	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.213	-5.583	3.37	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97D	97	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Asp	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.213	-2.723	0.51	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97E	97	Q	E	missense	low	0.449282773677785	0.319772540676215	6	0.130546593068351	0.193416152959411	0.705149394396159	0.684235335083512	0.985517092465529	0.353380802307167	0.222842610954415	NA	NA	0.164365361004003	0.285355440252082	0.53004663379379	0.619021698549322	0.670408008616378	0.524258052236662	0.466938696804194	NA	NA	0.519542507618119	0.535835215350918	NA	NA	p.Gln97Glu	1	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.213	-2.06	-0.153	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97F	97	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Phe	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.213	-4.745	2.532	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97G	97	Q	G	missense	wt-like	0.8347816519101	0.0630253607138482	6	0.0257299957672968	0.78435178688383	0.88521151693637	0.883876131390979	0.933022828652145	0.802358747295107	0.834239909988478	NA	NA	0.787781469498706	0.767410824635186	0.658828560158029	0.661544942575664	0.65905813094571	0.658598989370349	0.669435849894247	NA	NA	0.647782364609287	0.644250183440208	NA	NA	p.Gln97Gly	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.213	-3.093	0.88	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97H	97	Q	H	missense	possibly_wt-like	1.00542738987544	0.27381159381409	3	0.158085197395806	0.695586096490756	1.31526868326012	0.939201192334002	0.770803010925138	NA	1.30627796636718	NA	NA	NA	NA	0.673329112498675	0.673329112498675	0.623984297097786	NA	0.825776682145002	NA	NA	NA	NA	NA	NA	p.Gln97His	1	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.213	-3.475	1.262	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97I	97	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Ile	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.213	-3.293	1.08	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97K	97	Q	K	missense	low	0.23987454374413	0.546167533670421	6	0.222971961927814	-0.19714247119662	0.676891558684881	0.782790608986699	1.03768640191952	-0.0780748191085327	0.142515396848265	NA	NA	-0.119244350723917	-0.326425975457251	0.450768281592391	0.640013850653413	0.681687627329977	0.39516005720232	0.44033401242327	NA	NA	0.461202550761512	0.398244671171794	NA	NA	p.Gln97Lys	1	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.213	-2.332	0.119	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97L	97	Q	L	missense	possibly_low	0.700917544671962	0.160026946486083	6	0.0653307273310956	0.572871672019209	0.828963417324716	0.921952535063111	0.843266652486168	0.71909935214007	0.636720357345166	NA	NA	0.496900670348895	0.587565700648365	0.61885156918165	0.669655169718326	0.63965178926822	0.633686529203487	0.604016609159813	NA	NA	0.587946708173461	0.603802749369956	NA	NA	p.Gln97Leu	1	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.213	-2.812	0.599	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97M	97	Q	M	missense	wt-like	1.56596076778416	0.13992501260472	6	0.0571241471890114	1.45399949664614	1.67792203892219	1.51330531317066	1.45487791018559	1.57010541316096	1.52629170447871	NA	NA	1.84071982502361	1.49046444068545	0.835621568624297	0.795612584005509	0.771889341576217	0.88832031026163	0.898646084215756	NA	NA	0.86437712738991	0.806866009858685	NA	NA	p.Gln97Met	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.213	-3.67	1.457	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97N	97	Q	N	missense	possibly_low	0.551020015508099	0.648678502233792	6	0.264821889597605	0.0319786495789518	1.07006138143725	1.47608337190636	1.20394814348799	0.188621825794742	0.508829131944757	NA	NA	-0.0231808922356333	-0.0481814878496145	0.521310915842095	0.787684356304601	0.717635372684076	0.474959694593592	0.561658540045514	NA	NA	0.480963291638677	0.460822267485974	NA	NA	p.Gln97Asn	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.213	-3.449	1.236	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97P	97	Q	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Pro	1	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.213	-4.401	2.188	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97R	97	Q	R	missense	wt-like	0.96812778589267	0.0443203574349089	6	0.0180937101555489	0.932664765641088	1.00359080614425	0.967027226126412	1.02830826295472	0.961344287993413	0.939959362271028	NA	NA	1.00640270605797	0.905724869952482	0.686206912827137	0.679256023466399	0.679659963309248	0.706169848399271	0.704450541891215	NA	NA	0.692753862345026	0.675357216563726	NA	NA	p.Gln97Arg	1	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.213	-2.344	0.131	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97S	97	Q	S	missense	wt-like	1.01615454737382	0.0649699057820655	6	0.0265238529671265	0.964168750827011	1.06814034392062	1.07603621292062	0.9890754010615	0.946181373118787	1.10152580126559	NA	NA	0.950580133837723	1.03352836203867	0.702053840168518	0.702474803556694	0.671177356814542	0.701632876780341	0.757961972155929	NA	NA	0.681270875972266	0.704100410738304	NA	NA	p.Gln97Ser	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.213	-2.979	0.766	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97T	97	Q	T	missense	wt-like	0.910642723126484	0.185514581212635	6	0.0757360106361775	0.762202869946834	1.05908257630613	0.882529610598844	0.961845146830487	1.04173010754437	1.13463268481021	NA	NA	0.599481861140156	0.84363692783484	0.663341701010292	0.661258135303355	0.665289855361775	0.730222491633285	0.768927100193069	NA	NA	0.609048179659046	0.661393546658808	NA	NA	p.Gln97Thr	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.213	-2.847	0.634	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97V	97	Q	V	missense	wt-like	1.09780989292704	0.0948880559527984	6	0.0387378866281693	1.02188503029863	1.17373475555545	1.09830688184349	1.14010890468477	1.01320539465506	0.978878858000077	NA	NA	1.24529207072429	1.11106724765456	0.7194399251275	0.707218428641111	0.703832577895279	0.721687469581983	0.71734082959331	NA	NA	0.741894616881335	0.72153902066169	NA	NA	p.Gln97Val	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.213	-3.156	0.943	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97W	97	Q	W	missense	possibly_wt-like	0.773842359130677	0.130143369823471	6	0.0531308082456381	0.669707888499723	0.877976829761632	0.904502197214535	0.91241999312192	0.729760355071071	0.821602535188326	NA	NA	0.578456624669541	0.69631244951867	0.645740008322381	0.665938269223028	0.654603555417834	0.636876461226928	0.665250302421915	NA	NA	0.604723181826206	0.628260053842711	NA	NA	p.Gln97Trp	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.213	-4.517	2.304	0.008275262	NA	NA	NA	NA	NA	NA	NA
Q97X	97	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Ter	1	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q97Y	97	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Tyr	0	8.1	11.2	21.6	0.902	108.8	53.8	-63.1	-40.5	25.7009345794392	-5.5	1	0	15.81	0	0	0	0	7	14.1555000299945	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.213	-4.692	2.479	0.008275262	NA	NA	NA	NA	NA	NA	NA
E98A	98	E	A	missense	possibly_wt-like	0.72626476188934	0.43721807424473	6	0.178493531370313	0.376423868930155	1.07610565484852	1.08803836883269	1.14149073962343	0.508469242201627	1.05636722099705	NA	NA	0.0572569833280418	0.5059660163532	0.644791103348587	0.705031248001571	0.704131346872601	0.570662840237068	0.74300527549336	NA	NA	0.497509770817514	0.585450859824572	NA	NA	p.Glu98Ala	1	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.948	-2	0.052	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98C	98	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Cys	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.948	-3.983	2.035	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98D	98	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Asp	1	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.948	-1.958	0.01	0.008502717	NA	NA	NA	NA	8.13e-06	NA	NA
E98E	98	E	E	synonymous	wt-like	1.08818816417739	0.0826934417509731	6	0.0337594562274078	1.02202084583401	1.15435548252076	1.08873921491106	1.01451050975976	0.993137616829334	1.12963984811912	NA	NA	1.08091165413826	1.22219014130681	0.711881810217675	0.705180527354121	0.67667672667506	0.715682889380676	0.767273453346106	NA	NA	0.708080731054674	0.746530723606189	NA	NA	p.Glu98=	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98F	98	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Phe	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.948	-4.749	2.801	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98G	98	E	G	missense	wt-like	0.917527043575203	0.132365428406425	6	0.0540379598634399	0.81161458844484	1.02343949870557	1.02551081302541	1.07217706732757	0.928391532208756	0.942222608111147	NA	NA	0.826903258866151	0.709956981912185	0.690428935331814	0.691712955532588	0.68914491513104	0.696309889479981	0.705200137677934	NA	NA	0.655829915202475	0.631328729335111	NA	NA	p.Glu98Gly	1	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.948	-3.021	1.073	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98H	98	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98His	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.948	-3.86	1.912	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98I	98	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Ile	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.948	-4.396	2.448	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98K	98	E	K	missense	possibly_low	0.706446320323758	0.403712947580385	4	0.201856473790193	0.310814901648727	1.10207773899879	1.05866649762458	1.05327488502417	NA	NA	NA	NA	0.345329846506972	0.368514052139306	0.620912930711113	0.698775075565908	0.685058040846738	NA	NA	NA	NA	0.556767820575489	0.554537710014764	NA	NA	p.Glu98Lys	1	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.948	-3.808	1.86	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98L	98	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Leu	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.948	-3.4	1.452	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98M	98	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Met	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.948	-4.182	2.234	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98N	98	E	N	missense	wt-like	1.29172432803034	0.310032005659051	6	0.12657003629939	1.0436516153616	1.53979704069907	1.31034694062299	1.19570622277129	0.885142118847815	1.07715080561857	NA	NA	1.72958647589148	1.55241340442989	0.751135789763006	0.752382700321103	0.715853372421372	0.683369016133637	0.74988887920491	NA	NA	0.841516433536384	0.820798423322156	NA	NA	p.Glu98Asn	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.948	-4.036	2.088	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98P	98	E	P	missense	low	0.212258283149617	0.132980551423624	5	0.0594707105337258	0.0956978323685081	0.328818733930727	0.290614887097483	0.00534507673360621	NA	0.155003382134112	NA	NA	0.330077833802926	0.280250235979959	0.534687047368188	0.535181027338566	0.458483282625011	NA	0.44447008150995	NA	NA	0.553630404167182	0.534687047368188	NA	NA	p.Glu98Pro	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.948	-4.269	2.321	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98Q	98	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Gln	1	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.948	-1.915	-0.033	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98R	98	E	R	missense	possibly_wt-like	0.86624922222425	0.269915819828453	6	0.110192672014118	0.650275553716344	1.08222289073216	0.92957445900932	1.35138863384919	0.841888074034013	0.839298844062904	NA	NA	0.618675864124651	0.616669458265415	0.670769072718822	0.671278630142797	0.749513742009382	0.67042675698711	0.671111388450534	NA	NA	0.612996483471347	0.610348227453079	NA	NA	p.Glu98Arg	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.948	-3.244	1.296	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98S	98	E	S	missense	possibly_wt-like	0.87467473712085	0.483350005516235	5	0.21616069385184	0.451007562298055	1.29834191194364	1.47076520926164	1.23889247098946	0.65028239223271	NA	NA	NA	0.757108999848504	0.256324613271934	0.641472881957314	0.786551594203387	0.725190747569139	0.613095462341852	NA	NA	NA	0.641472881957314	0.529306139475775	NA	NA	p.Glu98Ser	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.948	-2.469	0.521	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98T	98	E	T	missense	wt-like	1.30581985545328	0.325470654498704	6	0.132872838295251	1.04539387787098	1.56624583303559	1.25825775535695	0.723334101714457	1.4238977422332	1.53217995755247	NA	NA	1.24597219434324	1.65127738151937	0.792533799791274	0.741287767936692	0.613720960238418	0.844572781573787	0.900596296436179	NA	NA	0.742034521760984	0.843033077821563	NA	NA	p.Glu98Thr	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.948	-3	1.052	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98V	98	E	V	missense	low	0.508295682339139	0.174048493290051	6	0.0710549998434745	0.369030441724429	0.647560922953848	0.456727743345191	0.782403558340423	0.608329053326921	0.539631571834428	NA	NA	0.336610654206114	0.326071512981755	0.571211644398267	0.570562861376411	0.626492471982272	0.600542393917428	0.571860427420123	NA	NA	0.554974238474378	0.54499232025777	NA	NA	p.Glu98Val	1	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.948	-4.008	2.06	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98W	98	E	W	missense	low	0.455518193986479	0.0770848018269145	6	0.0314697385665835	0.393838639793084	0.517197748179874	0.52933687944988	0.368083381618541	0.520987770378135	0.482653263432787	NA	NA	0.350931238548153	0.481116630491375	0.566164313512242	0.586028518046936	0.536911573410184	0.574408571682322	0.552988991027702	NA	NA	0.557920055342163	0.579862196234193	NA	NA	p.Glu98Trp	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.948	-5.84	3.892	0.008502717	NA	NA	NA	NA	NA	NA	NA
E98X	98	E	X	nonsense	low	0.202818157168826	0.272849157675991	6	0.111390202175729	-0.0155026273262368	0.421138941663889	-0.178016041282133	0.116683808618162	0.219912885407759	0.641187111854316	NA	NA	0.091836381714231	0.325304796700623	0.494472688811926	0.435363216077751	0.482556026865971	0.484322449087984	0.605496015550853	NA	NA	0.504622928535868	0.544819884633472	NA	NA	p.Glu98Ter	1	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E98Y	98	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu98Tyr	0	10.5	9.3	23.8	0.871	105.3	55.6	-62.2	-38.1	26.1682242990654	-6	1	0	15.96	1	26	1	26	8	13.7428553076959	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.948	-4.691	2.743	0.008502717	NA	NA	NA	NA	NA	NA	NA
F99A	99	F	A	missense	low	0.3714114305726	0.137687007080576	6	0.0562104852597309	0.261240903910008	0.481581957235192	0.635676664692713	0.32584777642036	0.371138607781228	0.283980629989747	NA	NA	0.363583707728905	0.248241196822648	0.528675596262971	0.608678761490293	0.527779738471987	0.529571454053954	0.487187845467067	NA	NA	0.560522732456559	0.527488167174681	NA	NA	p.Phe99Ala	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.012	-3.591	2.579	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99C	99	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Cys	1	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.012	-5.169	4.157	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99D	99	F	D	missense	low	0.0675981313321171	0.163910489796161	2	0.115902218842474	-0.159566043327411	0.294762305991645	0.183500350174591	-0.0483040875103565	NA	NA	NA	NA	NA	NA	0.479624732314499	0.512365762740414	0.446883701888585	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Asp	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.012	-4.367	3.355	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99E	99	F	E	missense	low	-0.00345810929933383	0.272437555023775	6	0.111222166096611	-0.221449549131223	0.214533330532555	0.284664740763572	0.291749532811261	0.0172913063661618	0.0243186817624249	NA	NA	-0.311472992291593	-0.327299925207829	0.42267758823004	0.533913653488986	0.520407296882488	0.423695032717483	0.401186802667367	NA	NA	0.421660143742597	0.398048118581802	NA	NA	p.Phe99Glu	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.012	-4.251	3.239	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99G	99	F	G	missense	low	0.0366795005590455	0.0542330861695383	6	0.0221405647152934	-0.00671520888030785	0.0800742099983988	0.0731762848536185	0.110153498795759	0.0426633745838441	0.0445485519748816	NA	NA	-0.0355233798611944	-0.0149413269926361	0.473361204035817	0.488866872541656	0.481144097023515	0.431286736184064	0.407887014022366	NA	NA	0.47842437930316	0.468298028768475	NA	NA	p.Phe99Gly	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.012	-4.037	3.025	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99H	99	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99His	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.012	-4.918	3.906	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99I	99	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Ile	1	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.012	-3.122	2.11	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99K	99	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Lys	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.012	-4.205	3.193	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99L	99	F	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Leu	1	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.012	-1.621	0.609	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99M	99	F	M	missense	possibly_low	0.686296171025947	0.103053461290387	6	0.0420713993981845	0.603837743426305	0.768754598625589	0.580633210607425	0.682929678179924	0.873280781875907	0.703141147406833	NA	NA	0.60585405267518	0.671938155410414	0.616568605441263	0.596954573481562	0.604985048328098	0.679819926156606	0.626015432044261	NA	NA	0.610358971792963	0.622778239089563	NA	NA	p.Phe99Met	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.012	-4.498	3.486	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99N	99	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Asn	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.012	-4.5	3.488	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99P	99	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Pro	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.012	-4.603	3.591	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99Q	99	F	Q	missense	low	0.0887099655447866	0.312138305034129	5	0.139592493687576	-0.184886294594996	0.36230622568457	-0.37892062251943	-0.0644840926362895	NA	0.267497833023991	NA	NA	0.404362231194032	0.215094478661629	0.481728679282002	0.392570787415995	0.44338539434887	NA	0.481728679282002	NA	NA	0.568911081660602	0.520033421292545	NA	NA	p.Phe99Gln	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.012	-4.628	3.616	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99R	99	F	R	missense	low	0.107669423813949	0.278346496484274	6	0.113634481346311	-0.115050067026709	0.330388914654606	0.385357899509029	0.536424075632085	-0.0654854923908874	-0.0698690544900955	NA	NA	-0.0990233796811299	-0.0413875056953085	0.463856175611956	0.555361172434572	0.573308812751257	0.398926972633268	0.369991459676377	NA	NA	0.465362107114669	0.462350244109243	NA	NA	p.Phe99Arg	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.012	-4.471	3.459	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99S	99	F	S	missense	low	0.0323886409421935	0.544134998052934	5	0.243344568916615	-0.444557949967797	0.509335231852184	0.598999643957855	0.652751220901182	NA	-0.36178223027319	NA	NA	-0.43032666321139	-0.29769876666349	0.404705462868283	0.600866601191826	0.598460110677369	NA	0.273308685416592	NA	NA	0.39721134052121	0.404705462868283	NA	NA	p.Phe99Ser	1	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.012	-4.004	2.992	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99T	99	F	T	missense	low	0.326285308045764	0.397057889405164	6	0.162098204564848	0.00857866514005601	0.643991950951472	0.475043513363855	1.02745780136154	0.143555310622743	-0.144701958445582	NA	NA	0.224064254477564	0.23229292689446	0.527862125325087	0.574464097859331	0.679476083503248	0.461475117123492	0.345206512094195	NA	NA	0.531822872942759	0.523901377707416	NA	NA	p.Phe99Thr	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.012	-3.934	2.922	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99V	99	F	V	missense	low	0.393745292084225	0.144323448697874	6	0.0589198012047561	0.278264603746643	0.509225980421806	0.624260971111717	0.515785655420901	0.315075800853053	0.282814444963941	NA	NA	0.265667342272976	0.358867537882761	0.546374516960687	0.6062472328005	0.568846543396542	0.512796621113601	0.486801600470442	NA	NA	0.540380839213725	0.552368194707649	NA	NA	p.Phe99Val	1	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.012	-2.679	1.667	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99W	99	F	W	missense	wt-like	0.962716707050482	0.179206355819412	6	0.0731606884035336	0.819324392695399	1.10610902140557	0.680553961911635	0.815758938027678	1.07440462324392	0.979440946626621	NA	NA	1.08665554985403	1.13948622263901	0.713394637536729	0.618237570592336	0.633704297648689	0.739999196944688	0.717526995523123	NA	NA	0.709262279550335	0.727930490119112	NA	NA	p.Phe99Trp	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.012	-5.001	3.989	0.005105041	NA	NA	NA	NA	NA	NA	NA
F99X	99	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Ter	0	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F99Y	99	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe99Tyr	1	12.4	12.5	24.4	0.965	111	42.1	-56.1	-52.3	0	-5	1	0	14.63	0	0	0	0	8	13.0427046556892	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.012	-2.744	1.732	0.005105041	NA	NA	NA	NA	NA	NA	NA
F100A	100	F	A	missense	low	-0.0268890650752339	0.200455407915256	6	0.0818355775956394	-0.18728384981672	0.133505719666252	0.18137738083472	0.243096233827318	-0.150339616476306	-0.158492305604977	NA	NA	-0.255057257118756	-0.0219188259134031	0.44999696284899	0.511913572882582	0.509887881014398	0.373537345644799	0.340639095711569	NA	NA	0.433265146744661	0.466728778953319	NA	NA	p.Phe100Ala	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.115	-2.754	1.639	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100C	100	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe100Cys	1	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.115	-5.182	4.067	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100D	100	F	D	missense	low	0.332374433059103	0.145978195869759	6	0.059595348908828	0.215569695551702	0.449179170566504	0.114714427751462	0.295312856507683	0.309196940467872	0.480703636119397	NA	NA	0.513059768992022	0.281258968516181	0.528045821105091	0.497714445880953	0.521177729404395	0.511037577886111	0.552343266911531	NA	NA	0.591270716762371	0.534913912805787	NA	NA	p.Phe100Asp	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.115	-4.296	3.181	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100E	100	F	E	missense	low	0.0480320301240901	0.196651113657909	6	0.0802824809686564	-0.109318741163999	0.205382801412179	0.072213284647666	0.0663550972838957	0.132893357500499	0.341987807305774	NA	NA	-0.233588244460745	-0.0916691215325495	0.464979633958728	0.488661754682418	0.47167436712888	0.458284900788576	0.506400047228251	NA	NA	0.437681431591154	0.451041834426301	NA	NA	p.Phe100Glu	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.115	-4.167	3.052	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100G	100	F	G	missense	low	0.11643531340285	0.104715743152447	6	0.0427500231266394	0.0326468077363821	0.200223819069317	0.212923615548732	0.211452622650442	0.10877310490898	0.184579818234256	NA	NA	-0.00523909111398414	-0.0138781898113271	0.476595570532361	0.51863288207022	0.503046159846681	0.451067759338269	0.45426591168174	NA	NA	0.484654011173595	0.468537129891127	NA	NA	p.Phe100Gly	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.115	-3.951	2.836	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100H	100	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe100His	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.115	-4.94	3.825	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100I	100	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe100Ile	1	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.115	-2.693	1.578	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100K	100	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe100Lys	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.115	-4.152	3.037	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100L	100	F	L	missense	possibly_wt-like	0.742106686145053	0.203956020037124	6	0.0832646965099693	0.578910879801855	0.90530249248825	0.987672189800009	0.992829699475009	0.665115480373027	0.617868060542415	NA	NA	0.494744611449365	0.694410075230491	0.62268297595421	0.683653375332574	0.671989080317971	0.617533744853503	0.597772655452793	NA	NA	0.587503195917084	0.627832207054917	NA	NA	p.Phe100Leu	1	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.115	-2.129	1.014	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100M	100	F	M	missense	wt-like	0.994279389255457	0.0623337363379725	6	0.0254476412982025	0.944402928819486	1.04415584969143	0.887009595678831	1.04747192382978	0.984750931451158	0.966266468245618	NA	NA	1.03702958806591	1.04314782826144	0.702658905145159	0.662212366614361	0.68380337233823	0.713173467290511	0.713163557264867	NA	NA	0.699053967387655	0.706263842902664	NA	NA	p.Phe100Met	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.115	-3.137	2.022	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100N	100	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe100Asn	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.115	-4.429	3.314	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100P	100	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe100Pro	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.115	-4.539	3.424	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100Q	100	F	Q	missense	low	0.00949418219117586	0.20674054904539	6	0.0844014757173407	-0.155929670456844	0.174918034839196	0.00617889507745465	0.39551702086521	-0.0412285672993246	-0.0066290772750297	NA	NA	-0.225788499661319	-0.0710846785599365	0.447478592367924	0.474596510935844	0.542843049097087	0.406185008546078	0.39093678502826	NA	NA	0.43928587867556	0.455671306060287	NA	NA	p.Phe100Gln	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.115	-3.725	2.61	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100R	100	F	R	missense	low	-0.121545686278823	0.311293687399223	6	0.127085115712925	-0.370627936047261	0.127536563489616	0.29119752707169	0.224778025538324	-0.2187689440198	-0.187444478260236	NA	NA	-0.457277663353757	-0.381758584649157	0.388733834326417	0.535305128936341	0.505927268785126	0.353062264202061	0.331050024010199	NA	NA	0.391667383031289	0.385800285621544	NA	NA	p.Phe100Arg	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.115	-4.428	3.313	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100S	100	F	S	missense	low	0.286076979733442	0.162741585581466	6	0.0664389741010118	0.15585898332567	0.416294976141215	0.0572253994569812	0.190750080137191	0.227767965588591	0.325310560387965	NA	NA	0.517340398856743	0.398067473973184	0.499723252480811	0.485469353574076	0.498570026495568	0.486672806927457	0.500876478466054	NA	NA	0.592151264047248	0.561184318244541	NA	NA	p.Phe100Ser	1	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.115	-3.052	1.937	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100T	100	F	T	missense	low	0.0752628509008179	0.16729796107314	6	0.0682991066061993	-0.0586009382235944	0.20912664002523	0.137265388147845	0.206323576377592	-0.143326350015856	0.287722455664967	NA	NA	-0.0835086156268918	0.0471006508572516	0.485339256931338	0.502517772704429	0.50193719967589	0.375635820189446	0.488427152621005	NA	NA	0.46855357280902	0.482251361241672	NA	NA	p.Phe100Thr	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.115	-3.915	2.8	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100V	100	F	V	missense	low	0.0787665321043149	0.205256570485667	6	0.0837956440072489	-0.0854699122112325	0.243002976419862	0.252869880328619	0.411403914779413	-0.0426138885747285	-0.0991874255750018	NA	NA	-0.0547877689916788	0.00491448065926697	0.473612612972939	0.527141387328633	0.546277982543036	0.405770499636573	0.360281101636996	NA	NA	0.47446159670346	0.472763629242419	NA	NA	p.Phe100Val	1	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.115	-2.861	1.746	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100W	100	F	W	missense	wt-like	0.847326132414189	0.125624125120405	6	0.0512858343214236	0.746807744227111	0.947844520601268	1.01908814611448	0.865989901010076	0.749144771001737	0.971962783635366	NA	NA	0.725394781381981	0.752376411341491	0.643620696169221	0.690344935381372	0.644564823041651	0.64267656929679	0.715050198981062	NA	NA	0.634949106287555	0.640868921680083	NA	NA	p.Phe100Trp	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.115	-5.094	3.979	0.004222325	NA	NA	NA	NA	NA	NA	NA
F100X	100	F	X	nonsense	low	-0.0326995112850299	0.376615852554715	6	0.153752777967053	-0.334049418623436	0.268650396053377	0.483914550541851	0.358756115018256	-0.271587249112879	-0.0910103722879425	NA	NA	-0.483084450672132	-0.193185661197333	0.407284705305276	0.576353617865581	0.534894908593409	0.337258234887865	0.362989373351496	NA	NA	0.386358795925478	0.428210614685073	NA	NA	p.Phe100Ter	0	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F100Y	100	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe100Tyr	1	9.4	14.4	25.6	0.906	116.5	49.4	-65.9	-40.5	0.43859649122807	-5	1	0	15.38	0	0	0	0	9	16.1835022394887	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.115	-2.849	1.734	0.004222325	NA	NA	NA	NA	NA	NA	NA
T101A	101	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101Ala	1	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.489	-2.052	-0.437	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101C	101	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101Cys	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.489	-4.481	1.992	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101D	101	T	D	missense	possibly_wt-like	1.01578087500506	0.402807713219086	4	0.201403856609543	0.621036569702889	1.41052518030724	0.614275991744538	0.866784133768255	1.56655840285317	NA	NA	NA	1.01550497165429	NA	0.669681395039311	0.604120444478265	0.644736545511737	0.887258991561924	NA	NA	NA	0.694626244566886	NA	NA	NA	p.Thr101Asp	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.489	-2.595	0.106	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101E	101	T	E	missense	wt-like	1.05669755612128	0.106312297513072	6	0.0434018137149972	0.971631564376169	1.14176354786639	1.01132389785144	0.99179211321089	1.0267934677518	1.18761776099719	NA	NA	0.934516624697997	1.18814147221836	0.707222192483097	0.688691160052495	0.671764741955738	0.7257532249137	0.786475962612114	NA	NA	0.677966530629267	0.738873127628018	NA	NA	p.Thr101Glu	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.489	-2.425	-0.064	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101F	101	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101Phe	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.489	-4.776	2.287	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101G	101	T	G	missense	wt-like	1.02363627329946	0.050992084045921	6	0.0208174311389369	0.982834858016497	1.06443768858241	0.99937922125343	1.00217834076748	1.06147930859721	1.10874588863827	NA	NA	0.997132415744049	0.972902464796299	0.690656236735921	0.686146958630805	0.674010366594766	0.736131748884552	0.760353293053717	NA	NA	0.690846916586125	0.690465556885716	NA	NA	p.Thr101Gly	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.489	-3.006	0.517	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101H	101	T	H	missense	possibly_wt-like	0.863791601047875	0.207428006677106	6	0.0846821291202554	0.697817677838004	1.02976552425775	1.1099878895716	1.05824031239485	0.721114444564726	0.623888471710098	NA	NA	0.698537112954251	0.970981375091729	0.660210549887216	0.709706468917862	0.686131624685159	0.634289475089273	0.59976663894571	NA	NA	0.62942434760494	0.690033500973128	NA	NA	p.Thr101His	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.489	-3.573	1.084	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101I	101	T	I	missense	wt-like	1.10251225387216	0.206988643425826	8	0.073181536697503	0.959079077611758	1.24594543013256	1.17331236406703	1.12622004256975	1.28605990297175	1.47852759683356	0.923268269275911	0.864405365543577	1.01891297930607	0.949391510409648	0.698078465737387	0.723194504087097	0.70082964244026	0.803329632092661	0.882826426796085	0.640981769473471	0.646092190392733	0.695327289034513	0.685177908511371	NA	NA	p.Thr101Ile	1	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.489	-3.353	0.864	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101K	101	T	K	missense	wt-like	1.45054691672905	0.356849218388359	5	0.159587822006808	1.13776053322452	1.76333330023358	0.995554081257921	NA	1.43072541816447	1.38300693297195	NA	NA	1.99587579831014	1.44757235294078	0.846615724647697	0.685332208517239	NA	0.846615724647697	0.851189613019174	NA	NA	0.896293498421185	0.797219515960329	NA	NA	p.Thr101Lys	1	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.489	-2.591	0.102	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101L	101	T	L	missense	possibly_wt-like	0.740293567656093	0.228999663792671	6	0.0934887212601571	0.557059041025481	0.923528094286705	1.01562874656157	0.980411322250617	0.795112049729027	0.6501489237001	NA	NA	0.534481109199752	0.465979254495487	0.63244743553787	0.689608087532166	0.669304081003262	0.656430668736743	0.608464202338997	NA	NA	0.595677195143931	0.576457778010237	NA	NA	p.Thr101Leu	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.489	-3.053	0.564	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101M	101	T	M	missense	possibly_low	0.711294709922096	0.123967630055549	2	0.0876583518599042	0.539487497332545	0.883101922511648	0.623636358062192	0.798953061782	NA	NA	NA	NA	NA	NA	0.618092430197988	0.606114190989316	0.63007066940666	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101Met	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.489	-3.762	1.273	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101N	101	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101Asn	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.489	-2.863	0.374	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101P	101	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101Pro	1	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.489	-4.425	1.936	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101Q	101	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101Gln	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.489	-2.851	0.362	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101R	101	T	R	missense	wt-like	1.04404412094282	0.171382474929974	6	0.0699666024056276	0.906912100107157	1.18117614177848	0.973001970575594	1.07959321859035	1.17677138239194	1.28084933533627	NA	NA	0.80264486078964	0.951403957973132	0.688189442630129	0.680528636684272	0.690748374318866	0.770628867085061	0.817354621074611	NA	NA	0.65083983962089	0.685630510941392	NA	NA	p.Thr101Arg	1	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.489	-2.898	0.409	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101S	101	T	S	missense	wt-like	0.956935082501154	0.142014252573212	6	0.057977075834517	0.843302101936553	1.07056806306575	0.9547819962893	1.16805997460885	1.08029084470613	0.897315895049455	NA	NA	0.832947415580799	0.80821436877239	0.683487332492068	0.676647804574504	0.709875928184568	0.741760442716862	0.690326860409632	NA	NA	0.657073228909255	0.653426960795835	NA	NA	p.Thr101Ser	1	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.489	-2.417	-0.072	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101T	101	T	T	synonymous	possibly_wt-like	0.858950756183673	0.21927164615547	2	0.15504846791847	0.555061343205358	1.16284016916199	1.01399922410214	0.703902288265203	NA	NA	NA	NA	NA	NA	0.649390287359857	0.689261001252856	0.609519573466859	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr101=	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101V	101	T	V	missense	wt-like	1.19145810416511	0.185013829358362	6	0.075531579547724	1.04341892855615	1.33949727977407	1.05148580795073	0.88449799195174	1.25042961961328	1.27693698805801	NA	NA	1.32267576064595	1.36272245677096	0.767974741769093	0.697245597498669	0.648566490135264	0.792668516752477	0.816058836505396	NA	NA	0.757812834575397	0.77813664896279	NA	NA	p.Thr101Val	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.489	-3.03	0.541	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101W	101	T	W	missense	possibly_wt-like	0.832893955437794	0.156610373192616	6	0.0639359171247932	0.707581860554662	0.958206050320927	0.783507465946097	0.805162226732084	0.848624373001417	1.09763266337051	NA	NA	0.612020881065274	0.850416122511387	0.651542368930205	0.640166540303927	0.631413163947987	0.672442358702509	0.756672549808814	NA	NA	0.611627519685869	0.662918197556484	NA	NA	p.Thr101Trp	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.489	-5.953	3.464	0.008757283	NA	NA	NA	NA	NA	NA	NA
T101X	101	T	X	nonsense	low	-0.118548532917877	0.0738936800183127	6	0.0301669685435599	-0.177674704786007	-0.0594223610497468	-0.100656075353033	-0.201942993222295	-0.181760415903443	-0.0938529764946868	NA	NA	0.00421048902289297	-0.137289225556696	0.427223483924218	0.451840793656666	0.41366516221185	0.364135771051542	0.362047891830172	NA	NA	0.486597837758869	0.440781805636586	NA	NA	p.Thr101Ter	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T101Y	101	T	Y	missense	wt-like	0.898881820038646	0.0643014862333628	6	0.026250971829056	0.847430860694521	0.950332779382771	0.89799832272777	0.951989380713186	0.810334272263509	0.831892019377485	NA	NA	0.940866517451652	0.960210407698272	0.666605585694841	0.664552951958056	0.663158922729217	0.660985386097291	0.668658219431626	NA	NA	0.679272735790703	0.687611094494365	NA	NA	p.Thr101Tyr	0	8.2	11.4	27.7	0.938	114.4	44.1	-61.5	-47.4	66.2576687116564	-4	1	0	19.01	1	4	0	0	7	18.1254963370058	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.489	-4.776	2.287	0.008757283	NA	NA	NA	NA	NA	NA	NA
E102A	102	E	A	missense	wt-like	0.957077685400988	0.101412315489518	6	0.0414014044305777	0.875932423807679	1.0382229469943	0.930542458134279	1.06451106015426	0.780905584909597	1.0090931550571	NA	NA	1.026132521968	0.931281332182688	0.684296168414292	0.671484812765633	0.687487434154664	0.652179881323899	0.727347921784152	NA	NA	0.696812385595048	0.68110490267392	NA	NA	p.Glu102Ala	1	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.208	-3	1.792	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102C	102	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Cys	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.208	-5.548	4.34	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102D	102	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Asp	1	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.208	-1.988	0.78	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102E	102	E	E	synonymous	wt-like	1.00960287436339	0.0373697763117842	2	0.026424422241487	0.957811958457797	1.06139379026898	1.03602729660488	0.983178452121903	NA	NA	NA	NA	NA	NA	0.68192766032377	0.693952953598213	0.669902367049326	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102=	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102F	102	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Phe	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.208	-4.716	3.508	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102G	102	E	G	missense	wt-like	0.819860325758851	0.0859085087402714	6	0.0350720018295156	0.751120465307278	0.888600186210425	0.6868799961075	0.944685534799075	0.820153614219455	0.831181652501808	NA	NA	0.776285531115252	0.859975625810017	0.662751612904578	0.619585008094115	0.661579745279557	0.663923480529598	0.66842294317149	NA	NA	0.645417591748616	0.665068143970622	NA	NA	p.Glu102Gly	1	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.208	-2.921	1.713	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102H	102	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102His	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.208	-4.767	3.559	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102I	102	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Ile	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.208	-4.423	3.215	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102K	102	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Lys	1	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.208	-2.91	1.702	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102L	102	E	L	missense	wt-like	0.918528937424155	0.125572726324487	5	0.0561578304363059	0.808461612319088	1.02859626252922	1.13816082096411	0.876356097355401	0.824884648346265	NA	NA	NA	0.896314405064816	0.856928715390178	0.665339076919804	0.715707268647675	0.646806116697046	0.665339076919804	NA	NA	NA	0.670108140196698	0.664382889315992	NA	NA	p.Glu102Leu	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.208	-3.98	2.772	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102M	102	E	M	missense	low	0.425737646886152	0.286854328728363	4	0.143427164364181	0.14462557032765	0.706849723444654	0.493828615590542	0.70946717580301	0.0264123573342169	NA	NA	NA	0.47324243881684	NA	0.58077269571039	0.578465301525214	0.610722767648792	0.426424188009789	NA	NA	NA	0.583080089895566	NA	NA	NA	p.Glu102Met	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.208	-5.094	3.886	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102N	102	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Asn	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.208	-3.036	1.828	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102P	102	E	P	missense	low	-0.13451652590857	0.165216255088623	6	0.0674492536967718	-0.266714633938348	-0.002318417878792	-0.0121923394107116	0.127104671650962	-0.271672172278443	-0.177105395025736	NA	NA	-0.312770478321401	-0.16046344206609	0.428481567195289	0.470683460589149	0.484809140102601	0.33723282460263	0.334474368415801	NA	NA	0.421393244282279	0.435569890108299	NA	NA	p.Glu102Pro	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.208	-4.139	2.931	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102Q	102	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Gln	1	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.208	-2.598	1.39	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102R	102	E	R	missense	possibly_low	0.69731198922003	0.166684567063694	6	0.0680486895504623	0.563939008505976	0.830684969934083	0.781900191295631	0.952629887246562	0.627510108272509	0.557122878360852	NA	NA	0.502716334125908	0.761992536018716	0.62305292305505	0.639824192780559	0.663297407780211	0.606281653329541	0.577653615877158	NA	NA	0.589143019723501	0.643031602325914	NA	NA	p.Glu102Arg	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.208	-2.828	1.62	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102S	102	E	S	missense	wt-like	0.982323086030674	0.144175177076929	6	0.058859269568981	0.866961037519137	1.09768513454221	0.701878391576885	0.985849450845444	1.10641763463509	1.05408322677723	NA	NA	1.0496514996901	0.996058312659293	0.698661849967948	0.622779647878891	0.670479868409827	0.749577970242508	0.742248807762935	NA	NA	0.701650358657604	0.695673341278291	NA	NA	p.Glu102Ser	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.208	-2.813	1.605	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102T	102	E	T	missense	possibly_low	0.552091069858674	0.594951718394615	5	0.266070497132134	0.0306024781310239	1.07357966158632	1.07902360413363	1.29772463216014	0.260886396725778	NA	NA	NA	-0.0277737228670151	0.150594439140839	0.505527267118262	0.70311111421014	0.737910953242698	0.496582338397843	NA	NA	NA	0.48001852307186	0.505527267118262	NA	NA	p.Glu102Thr	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.208	-3.173	1.965	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102V	102	E	V	missense	wt-like	1.06113508642084	0.146988341381195	6	0.0600077390869915	0.943522079016658	1.17874809382502	0.817068564973887	0.951371750090721	1.19678448528267	1.13231848002292	NA	NA	1.10192657033548	1.16734066781935	0.723299300972257	0.647315013111824	0.663025383719401	0.776617087725533	0.768160626605708	NA	NA	0.712403605954908	0.734194995989607	NA	NA	p.Glu102Val	1	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.208	-4.01	2.802	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102W	102	E	W	missense	low	0.588456728931587	0.15256535453675	6	0.0622845451736414	0.466381263597792	0.710532194265382	0.630782923060753	0.840441780217917	0.391863997750586	0.479243532268628	NA	NA	0.579192805995619	0.609215334296018	0.606255509301685	0.607636400542698	0.63904101863633	0.535772801674759	0.551859674861871	NA	NA	0.604874618060672	0.608671783960367	NA	NA	p.Glu102Trp	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.208	-5.776	4.568	0.005268474	NA	NA	NA	NA	NA	NA	NA
E102X	102	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Ter	1	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E102Y	102	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu102Tyr	0	11.6	10.9	29.3	0.822	115.9	45.9	-71.5	-32.5	44.392523364486	-3.6	1	0	19.57	1	30	1	30	7	17.4859096316042	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.208	-4.635	3.427	0.005268474	NA	NA	NA	NA	NA	NA	NA
Q103A	103	Q	A	missense	wt-like	1.0661571518916	0.0929903108024824	6	0.0379631354148167	0.991750773738341	1.14056353004486	1.11223541156133	0.938151698907693	1.11905858191617	1.08349089649055	NA	NA	1.17582997823742	0.968176344236434	0.718895550157002	0.710185188336897	0.660167053059488	0.753360331320498	0.751988741853857	NA	NA	0.727605911977107	0.689402645389894	NA	NA	p.Gln103Ala	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-1.973	-2.76	0.787	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103C	103	Q	C	missense	possibly_wt-like	0.805013240565704	0.190231819565053	6	0.077661815129263	0.65279887993834	0.957227601193067	0.744743679461945	0.802263152753557	0.751399557995501	1.11877160862773	NA	NA	0.538294749463325	0.874606695092166	0.637630568430832	0.631909901467885	0.630786350033014	0.643351235393779	0.763673850339053	NA	NA	0.596461680298152	0.66835869306669	NA	NA	p.Gln103Cys	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-1.973	-4.33	2.357	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103D	103	Q	D	missense	possibly_low	0.671312927756544	0.179501643434001	6	0.0732812390673847	0.527684338442	0.814941517071087	0.426250954334435	0.623837617067549	0.600204105992885	0.610907614420714	NA	NA	0.873855637944278	0.892821636779401	0.596789308259856	0.564071342807993	0.592208649228238	0.598111287776913	0.5954673287428	NA	NA	0.665488257834835	0.672455260361124	NA	NA	p.Gln103Asp	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-1.973	-4.006	2.033	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103E	103	Q	E	missense	possibly_low	0.535496198943345	0.233829972675705	6	0.0954606866040683	0.348396691259906	0.722595706626784	0.687612102417758	0.898741844921519	0.523960223745562	0.387118765063189	NA	NA	0.48617579174728	0.229368465764763	0.580519260274008	0.619740945837603	0.651646178791166	0.575297974325422	0.521347595208169	NA	NA	0.585740546222594	0.523243662079034	NA	NA	p.Gln103Glu	1	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-1.973	-3.338	1.365	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103F	103	Q	F	missense	wt-like	1.03655334843974	0.00787155680005046	2	0.00556603119181076	1.02564412776696	1.04746256911252	1.03098731724793	1.04211937963155	NA	NA	NA	NA	NA	NA	0.687762766740295	0.692879444195089	0.682646089285501	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln103Phe	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-1.973	-3.954	1.981	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103G	103	Q	G	missense	wt-like	0.875011093148858	0.0781328540365072	6	0.0318976040894666	0.812492937940386	0.937529248357331	0.99893507553392	0.941527446842323	0.861281749331152	0.806636649085121	NA	NA	0.818587562935799	0.823098075164835	0.660595236241405	0.686052356138913	0.660896929494012	0.676229635598339	0.660293542988798	NA	NA	0.654119334352286	0.65677432835123	NA	NA	p.Gln103Gly	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-1.973	-3.203	1.23	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103H	103	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln103His	1	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-1.973	-2.309	0.336	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103I	103	Q	I	missense	wt-like	0.972475300628966	0.0964264683531908	6	0.0393659408606579	0.895319474324543	1.04963112693339	0.837751880804987	0.93903993713805	1.12337584881247	1.01949172813743	NA	NA	0.927615371313324	0.987577037567534	0.685156398884472	0.651720533940369	0.660359100619062	0.754652122347607	0.730791969457066	NA	NA	0.676546907788197	0.693765889980747	NA	NA	p.Gln103Ile	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-1.973	-3.606	1.633	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103K	103	Q	K	missense	possibly_low	0.716597952111088	0.210568620148081	6	0.0859642792007887	0.548111060920597	0.88508484330158	0.829969908500193	0.949116251173697	0.669577762667878	0.606546817019364	NA	NA	0.374570520650287	0.86980645265511	0.63446595503796	0.650062983412403	0.662537718307318	0.618868926663517	0.594023015756185	NA	NA	0.562782775626167	0.667279111451187	NA	NA	p.Gln103Lys	1	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-1.973	-3.36	1.387	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103L	103	Q	L	missense	possibly_low	0.696712185965864	0.210889408502532	6	0.0860952404980941	0.527968615349286	0.865455756582443	0.798074221452021	0.90031380335953	0.784076306419727	0.810754847459044	NA	NA	0.339123650997321	0.547930286107542	0.647627648007092	0.643269241307466	0.651986054706718	0.653128608769904	0.661657506238059	NA	NA	0.555491174666324	0.594888686086236	NA	NA	p.Gln103Leu	1	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-1.973	-2.286	0.313	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103M	103	Q	M	missense	wt-like	0.936069578172071	0.175287776833455	6	0.0715609352314691	0.795812722418388	1.07632643392575	1.01695850833096	1.08232427625238	0.665464999686859	0.810900857668524	NA	NA	1.12664715016006	0.914121676933639	0.683568498005828	0.689891325153245	0.691338861128735	0.617638326276022	0.661705865384866	NA	NA	0.717488754667374	0.677245670858411	NA	NA	p.Gln103Met	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-1.973	-3.717	1.744	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103N	103	Q	N	missense	wt-like	1.32281080586619	0.381328517011989	6	0.155676715175265	1.01769005089117	1.62793156084121	0.747077392076889	1.02491938077237	1.48471047369166	1.36405338233581	NA	NA	1.8226167062137	1.4934875001067	0.826229012019463	0.632406979384063	0.678927247095785	0.862768863196478	0.844912123650428	NA	NA	0.860653223987923	0.807545900388498	NA	NA	p.Gln103Asn	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-1.973	-1.987	0.014	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103P	103	Q	P	missense	low	0.27190007146375	0.0919922206258611	6	0.0375556668064823	0.198292317107658	0.345507825819842	0.266801296398256	0.322279118661244	0.361451232919938	0.344513751591277	NA	NA	0.217876119780543	0.118478909431242	0.526840499409605	0.530108761813803	0.527008152662946	0.526672846156264	0.507236649757387	NA	NA	0.530549942234401	0.498304437042228	NA	NA	p.Gln103Pro	1	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-1.973	-4.427	2.454	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103R	103	Q	R	missense	possibly_wt-like	0.736901464691704	0.0960532482187355	6	0.0392135743787999	0.660044271204174	0.813758658179235	0.761171254606882	0.909721451301104	0.64625846835231	0.750256154351966	NA	NA	0.68423486353816	0.669766595999806	0.630945628544958	0.635408954765455	0.654020098915532	0.611891443946111	0.641620104798427	NA	NA	0.62648230232446	0.622289852170067	NA	NA	p.Gln103Arg	1	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-1.973	-2.614	0.641	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103S	103	Q	S	missense	wt-like	0.940869659140854	0.0464226965153167	6	0.0189519864911008	0.903724448182807	0.978014870098901	0.992345175223362	0.904656985133767	0.881602443277773	0.953630132237364	NA	NA	0.992897131245188	0.920086087727671	0.683479303788403	0.684648715479298	0.652925101723632	0.682309892097507	0.708978353844434	NA	NA	0.689975697073107	0.678587075657226	NA	NA	p.Gln103Ser	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-1.973	-2.82	0.847	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103T	103	Q	T	missense	possibly_wt-like	0.73042411481941	0.177510261321431	6	0.0724682607242678	0.588388933777587	0.872459295861234	0.848038286851459	0.725382229524579	0.402415875922225	0.732726477393156	NA	NA	0.918793358044995	0.755188461180051	0.638657781874309	0.653911525774495	0.614163789576523	0.538930081933005	0.635814207905595	NA	NA	0.67473217489232	0.641501355843023	NA	NA	p.Gln103Thr	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-1.973	-3.573	1.6	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103V	103	Q	V	missense	wt-like	0.877772335050337	0.130540204908678	6	0.0532928154907702	0.773320336053689	0.982224334046985	0.933543192517096	1.09829975759743	0.712937891693831	0.805783827457111	NA	NA	0.845206905599038	0.870862435437514	0.663763844350993	0.672123965497835	0.694792948219869	0.631842927797895	0.66001108516303	NA	NA	0.659595068215781	0.667516603538955	NA	NA	p.Gln103Val	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-1.973	-3.987	2.014	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103W	103	Q	W	missense	wt-like	0.959758022422989	0.119872863765259	6	0.0489378917051743	0.863841517201526	1.05567452764445	0.943529775459934	1.02420244550717	0.887299599658669	0.827657688536828	NA	NA	1.16542216579061	0.910436459584723	0.677594548642949	0.674251095379713	0.678772237253438	0.684014566760819	0.667255792659658	NA	NA	0.725464972143209	0.676416860032459	NA	NA	p.Gln103Trp	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-1.973	-5.764	3.791	0.008403751	NA	NA	NA	NA	NA	NA	NA
Q103X	103	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln103Ter	1	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q103Y	103	Q	Y	missense	wt-like	0.974600870972593	0.206977506525317	6	0.0844982132034337	0.808987416335876	1.14021432560931	0.792420808330998	0.751134850638884	1.10929813197959	0.936337734218568	NA	NA	0.950799498882352	1.30761420178517	0.692283522565249	0.642065071267206	0.61973180935837	0.750439858263939	0.703251044655403	NA	NA	0.681316000475096	0.765742721004933	NA	NA	p.Gln103Tyr	0	12.2	14.5	30.1	0.373	109	-124.2	-87.8	2.1	21.0280373831776	-3.1	0	0	19.11	0	0	0	0	6	18.32971207454	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-1.973	-3.685	1.712	0.008403751	NA	NA	NA	NA	NA	NA	NA
N104A	104	N	A	missense	wt-like	0.976148415262904	0.0550737451410603	6	0.0224837623032803	0.932081050911515	1.02021577961429	1.05448757936404	0.941242383880483	0.941954855250933	1.03526520684326	NA	NA	0.962092863390444	0.921847602848265	0.690762036989374	0.697884971117089	0.660835295526598	0.700368239224047	0.736016206687593	NA	NA	0.68363910286166	0.678983243010138	NA	NA	p.Asn104Ala	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.067	-2.806	0.739	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104C	104	N	C	missense	wt-like	1.10723028057606	0.378245512912673	6	0.154418084022226	0.804576397330822	1.40988416382131	0.529108245797197	0.727535790501724	1.37533340493325	1.37690106928399	NA	NA	1.27177725375449	1.36272591918574	0.76274009054626	0.585979819360167	0.61462941480624	0.830041603245357	0.849167327320623	NA	NA	0.747342753427533	0.778137427664988	NA	NA	p.Asn104Cys	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.067	-3.898	1.831	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104D	104	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104Asp	1	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.067	-2.544	0.477	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104E	104	N	E	missense	wt-like	0.921538328135877	0.147553429514966	6	0.0602384353515649	0.803473164361766	1.03960349190999	0.894843242313368	1.16747934109017	0.845371470034905	0.951884649759229	NA	NA	0.721027586302562	0.948623679315031	0.678237131747832	0.663880923710995	0.70975038838403	0.67146904133179	0.708400243288255	NA	NA	0.634050752098746	0.685005222163873	NA	NA	p.Asn104Glu	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.067	-2.539	0.472	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104F	104	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104Phe	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.067	-3.696	1.629	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104G	104	N	G	missense	wt-like	0.962116546582169	0.0787830267956689	6	0.0321630360069005	0.899078154375179	1.02515493878916	0.877193343315106	1.00410794142447	1.06207954170833	1.01937899851554	NA	NA	0.871387796488758	0.938551658040804	0.678583789333616	0.660121516936302	0.674427568967353	0.736311347636667	0.730754632969749	NA	NA	0.664980610324576	0.682740009699879	NA	NA	p.Asn104Gly	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.067	-1.914	-0.153	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104H	104	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104His	1	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.067	-3.436	1.369	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104I	104	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104Ile	1	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.067	-3.953	1.886	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104K	104	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104Lys	1	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.067	-2.797	0.73	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104L	104	N	L	missense	possibly_wt-like	0.76293246664917	0.221038240803162	6	0.0902384839350306	0.586068288117014	0.939796645181326	1.03761341197056	1.02761286981686	0.691818481167285	0.723590628319238	NA	NA	0.558460391147846	0.538499017473235	0.629156031314219	0.694290794219951	0.679509611128374	0.625523683314909	0.63278837931353	NA	NA	0.600609855121549	0.592767579837546	NA	NA	p.Asn104Leu	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.067	-3.39	1.323	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104M	104	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104Met	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.067	-5.201	3.134	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104P	104	N	P	missense	low	-0.153281998596113	0.217025723306229	6	0.0886003805264512	-0.326935553444502	0.020371556252275	0.0972673087708028	0.0817356777123052	-0.179072956788145	-0.135738895623116	NA	NA	-0.355866293580754	-0.428016832067773	0.39396247691847	0.493998231000561	0.474999829640116	0.364939899138652	0.34817511321066	NA	NA	0.412528216397258	0.375396737439682	NA	NA	p.Asn104Pro	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.067	-4.427	2.36	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104Q	104	N	Q	missense	wt-like	1.16222170244857	0.273853766275538	6	0.111800331919079	0.94309707842755	1.38134632646959	1.26860907622826	0.876190968660471	1.14315169124402	0.833525940076429	NA	NA	1.55700412000576	1.29484841847647	0.752030968823871	0.743492586548655	0.64677041392971	0.760569351099086	0.669199380294512	NA	NA	0.80601536717571	0.762871677479885	NA	NA	p.Asn104Gln	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.067	-2.666	0.599	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104R	104	N	R	missense	possibly_wt-like	0.849610427082556	0.310456113231649	6	0.126743177490876	0.601198363914272	1.09802249025084	1.02200994668382	1.05743283840585	0.872994791724345	1.05815027296225	NA	NA	0.245538952727343	0.841535759991726	0.682845696458845	0.690967275308402	0.685957039305127	0.679734353612563	0.743595829209143	NA	NA	0.53624032734433	0.660920990906832	NA	NA	p.Asn104Arg	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.067	-2.784	0.717	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104S	104	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104Ser	1	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.067	-2.595	0.528	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104T	104	N	T	missense	possibly_low	0.490848855859712	0.326117581330205	3	0.188284073368463	0.121818853195027	0.859878858524397	NA	NA	0.514180559763259	0.153691989366245	NA	NA	0.804674018449631	NA	0.572371752138116	NA	NA	0.572371752138116	0.444035743146834	NA	NA	0.651257247648344	NA	NA	NA	p.Asn104Thr	1	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.067	-3.627	1.56	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104V	104	N	V	missense	possibly_low	0.706305776031392	0.108200280743314	6	0.0441725796411678	0.619729110830475	0.792882441232308	0.83860978339537	0.796731303039313	0.593217239433977	0.574791201710752	NA	NA	0.752816785458892	0.681668343150044	0.627278435852005	0.651903266136776	0.629590299017375	0.596020712478884	0.58350543299163	NA	NA	0.640589951676882	0.624966572686635	NA	NA	p.Asn104Val	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.067	-3.742	1.675	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104W	104	N	W	missense	possibly_low	0.64738753056363	0.193613599513663	6	0.0790424210120078	0.492467232129242	0.802307828998017	0.78986266062827	0.934733277185657	0.644976711809737	0.599717580484421	NA	NA	0.386156150098796	0.528878803174896	0.601634534663942	0.641520188953418	0.659427950049876	0.611507923158445	0.591761146169439	NA	NA	0.565165998394049	0.590603979429884	NA	NA	p.Asn104Trp	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.067	-4.488	2.421	0.008274616	NA	NA	NA	NA	NA	NA	NA
N104X	104	N	X	nonsense	low	-0.197040488708298	0.358351613044869	6	0.146296433410536	-0.48377622925961	0.0896952518430141	0.364972335299337	0.0917876110371147	-0.358588349306911	-0.241952752025651	NA	NA	-0.45977007359668	-0.578691703656996	0.36633220891186	0.55101907233511	0.477173175931739	0.311226200436725	0.312996672654562	NA	NA	0.391154681596789	0.34150973622693	NA	NA	p.Asn104Ter	0	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N104Y	104	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn104Tyr	1	8.7	14.9	31.4	0.926	59.8	147.5	51.6	52.6	80.2139037433155	-2	0	0	21.1	0	0	0	0	6	21.2079273173777	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.067	-4.696	2.629	0.008274616	NA	NA	NA	NA	NA	NA	NA
L105A	105	L	A	missense	possibly_low	0.492673673343942	0.654441676727855	6	0.267174695732451	-0.0309791078721094	1.01632645455999	1.16754040449878	1.01813882378434	0.697398826097424	0.654488798025067	NA	NA	-0.529791805960972	-0.0517330063809924	0.618547495880663	0.721965083799408	0.677461210870822	0.627193406239638	0.609901585521688	NA	NA	0.376750855929928	0.460023525721601	NA	NA	p.Leu105Ala	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.448	-3.012	1.564	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105C	105	L	C	missense	wt-like	0.928901829530942	0.0739369150080162	6	0.0301846191541946	0.869741063101663	0.988062595960222	0.812290180179426	0.911171029089855	0.960555183409633	0.983337186488508	NA	NA	1.01741551596433	0.888641882053899	0.68326724028748	0.646297223028711	0.654333514694348	0.705933736468908	0.718817445253657	NA	NA	0.695019253226363	0.671515227348597	NA	NA	p.Leu105Cys	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.448	-4.139	2.691	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105D	105	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu105Asp	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.448	-4.387	2.939	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105E	105	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu105Glu	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.448	-3.682	2.234	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105F	105	L	F	missense	possibly_low	0.553923369985233	0.302581083244572	8	0.106978567910504	0.344249229762973	0.763597510207493	0.785798228141741	1.12100583197569	0.372251131130771	0.291465510827926	0.771709489420654	0.303453908872818	0.421097670117565	0.364605189394704	0.563006123689356	0.640654469833629	0.699702268740877	0.529904337731269	0.489666866986044	0.618821643473601	0.538315620664634	0.572353646369782	0.553658601008931	NA	NA	p.Leu105Phe	1	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.448	-3.183	1.735	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105G	105	L	G	missense	low	0.428594168802149	0.203257060853423	6	0.0829793476181194	0.265957636010005	0.591230701594292	0.7368938289251	0.622743174286673	0.390189952662933	0.26868711495507	NA	NA	0.292799987518426	0.260250954464691	0.540617032146006	0.630237892959992	0.591972017817906	0.53527190226892	0.482122574063097	NA	NA	0.545962162023093	0.530189179410419	NA	NA	p.Leu105Gly	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.448	-3.1	1.652	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105H	105	L	H	missense	possibly_low	0.508011814772015	0.752098823938676	4	0.376049411969338	-0.229031489095353	1.24505511863938	0.959308297032356	1.3319470055475	NA	NA	NA	NA	-0.155219441458848	-0.103988602032951	0.565707096554731	0.677611901064768	0.745310233151209	NA	NA	NA	NA	0.453802292044695	0.448271165062164	NA	NA	p.Leu105His	1	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.448	-4.132	2.684	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105I	105	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu105Ile	1	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.448	-2.039	0.591	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105K	105	L	K	missense	low	0.414112403785106	0.096075242223356	6	0.0392225533935866	0.337237611751977	0.490987195818235	0.573497548725997	0.369106365545714	0.441859044063045	0.440799881829739	NA	NA	0.291027354561267	0.368384227984871	0.548164796016655	0.595434686278718	0.537132754575306	0.550732069604586	0.539126988962599	NA	NA	0.545597522428725	0.554508512370642	NA	NA	p.Leu105Lys	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.448	-3.653	2.205	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105L	105	L	L	synonymous	wt-like	0.918215306114866	0.115026470801446	6	0.0469593600627817	0.826176651654765	1.01025396057497	0.953030747457492	0.98846981208918	0.950064455540653	0.973165700537092	NA	NA	0.685228071730928	0.959333049333849	0.681844283014851	0.676274790727619	0.671046421351213	0.702794753298652	0.715448609717237	NA	NA	0.626686610289666	0.687413775302082	NA	NA	p.Leu105=	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105M	105	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu105Met	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.448	-2.953	1.505	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105N	105	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu105Asn	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.448	-4.469	3.021	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105P	105	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu105Pro	1	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.448	-4.526	3.078	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105Q	105	L	Q	missense	wt-like	0.978541927073389	0.127208012693517	6	0.0519324537154337	0.876756188162346	1.08032766598443	0.900490386149106	0.977700089767676	0.962319106508498	0.920131215143497	NA	NA	1.2275789924329	0.883031772438656	0.684068444092964	0.665083758401201	0.668717880630446	0.706461528724137	0.697883382777626	NA	NA	0.738250946793237	0.670253505408302	NA	NA	p.Leu105Gln	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.448	-3.877	2.429	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105R	105	L	R	missense	low	0.286819995698821	0.212693383375567	6	0.0868317101560502	0.116632971076941	0.4570070203207	0.538054726905493	0.475017976172819	0.345871100498419	0.284901488247435	NA	NA	0.0594626837787031	0.0176119985900545	0.509987265690335	0.587885408830764	0.560032091325594	0.52201103678781	0.487492837288058	NA	NA	0.49796349459286	0.475619319783125	NA	NA	p.Leu105Arg	1	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.448	-4.448	3	0.00693434	NA	NA	NA	NA	8.13e-06	NA	NA
L105S	105	L	S	missense	possibly_low	0.656693457901762	0.23653563399838	6	0.0965652682136248	0.467429010045607	0.845957905757917	0.74318444201268	1.0085855309135	0.780540522324243	0.5384673012331	NA	NA	0.536060922227277	0.333322028699771	0.613789978254802	0.63157778580928	0.675395676514125	0.652070649121346	0.571474816488299	NA	NA	0.596002170700324	0.546622971953955	NA	NA	p.Leu105Ser	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.448	-3.389	1.941	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105T	105	L	T	missense	wt-like	0.977449389596566	0.123350116160364	6	0.0503574740509874	0.87875055410422	1.07614822508891	1.00056092430842	0.947536817855183	1.06976440326111	1.08376072905439	NA	NA	0.746583568921969	1.01648989417833	0.693333547036697	0.686398659927851	0.662196226234625	0.738610773508847	0.752078111443934	NA	NA	0.639307747405291	0.700268434145544	NA	NA	p.Leu105Thr	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.448	-3.2	1.752	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105V	105	L	V	missense	wt-like	1.00179099846972	0.101137388656734	6	0.0412891660210907	0.920865720116686	1.08271627682275	0.894425803826575	1.12539005387498	1.00499762643612	1.05639206561234	NA	NA	0.868315022618885	1.06122541844941	0.705489854378929	0.663792009826818	0.700650189115853	0.719231582190148	0.743013504126153	NA	NA	0.664348525147004	0.710329519642005	NA	NA	p.Leu105Val	1	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.448	-2.258	0.81	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105W	105	L	W	missense	possibly_low	0.673024614225614	0.153399510869845	6	0.0626250880706068	0.550281697078575	0.795767531372652	0.688001299391797	0.811594053468394	0.727397849305852	0.76860411935435	NA	NA	0.379706138374318	0.662844225458971	0.626768400698563	0.619823844314304	0.632803800588127	0.636169564057421	0.647697021860129	NA	NA	0.56383919825227	0.620733000809	NA	NA	p.Leu105Trp	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.448	-3.667	2.219	0.00693434	NA	NA	NA	NA	NA	NA	NA
L105X	105	L	X	nonsense	low	-0.123374443043971	0.111559853246015	6	0.0455441193720852	-0.212639276720851	-0.0341096093670915	-0.175039531274103	-0.0653557610398514	0.00436051110550964	-0.0282626608728694	NA	NA	-0.285743270418019	-0.190205945764495	0.427916817591605	0.435997209047923	0.443196929380869	0.419825944775432	0.38377165836411	NA	NA	0.42695287809535	0.428880757087859	NA	NA	p.Leu105Ter	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L105Y	105	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu105Tyr	0	7.9	17.7	29	0.968	43.2	-138.4	-119.7	128.7	17.8010471204188	-3.1	0	0	19.83	0	0	0	0	5	20.549630370688	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.448	-2.937	1.489	0.00693434	NA	NA	NA	NA	NA	NA	NA
S106A	106	S	A	missense	wt-like	1.19584534212663	0.0823351948726778	6	0.0336132025517797	1.12996467572009	1.26172600853317	1.09060484558207	1.19307348931464	1.30591078150075	1.27271414314594	NA	NA	1.1274479979426	1.18532079527377	0.727946123168134	0.705577904392049	0.71528414446194	0.809269312770261	0.814660213917456	NA	NA	0.717653493120079	0.738238753216189	NA	NA	p.Ser106Ala	1	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.245	-2.454	0.209	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106C	106	S	C	missense	possibly_low	0.533165349499121	0.34940790755793	6	0.14264518093508	0.253585932298164	0.812744766700079	1.19263604553247	0.608062792075385	0.209541985764879	0.465802992753882	NA	NA	0.332382111564502	0.390566169303609	0.556800834769133	0.727310424468304	0.588797946402235	0.481219320320754	0.547408116125792	NA	NA	0.554104405795606	0.559497263742659	NA	NA	p.Ser106Cys	1	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.245	-5.464	3.219	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106D	106	S	D	missense	wt-like	1.15492842301692	0.170537638525906	6	0.0696216993879454	1.01847239967407	1.29138444635977	1.23404709105352	1.21521211705378	1.26152931340918	1.28987583683237	NA	NA	1.09365309756482	0.835253082187844	0.728100851281834	0.736130926222693	0.720070776340975	0.795989711664353	0.820344233325453	NA	NA	0.710701710622926	0.659508007387325	NA	NA	p.Ser106Asp	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.245	-2.918	0.673	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106E	106	S	E	missense	wt-like	0.982441996553461	0.126505100609432	6	0.0516454910587595	0.881218694114407	1.08366529899251	0.89829525725721	1.01694541032002	1.05933098728047	0.994583865258789	NA	NA	1.14290304125191	0.782593417952361	0.69901792739402	0.664616198647554	0.677203180833888	0.735488938915429	0.722542388815394	NA	NA	0.720832673954153	0.647664771106521	NA	NA	p.Ser106Glu	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.245	-2.462	0.217	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106F	106	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser106Phe	1	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.245	-4.071	1.826	0.009041106	NA	NA	NA	NA	4.06e-06	NA	NA
S106G	106	S	G	missense	wt-like	0.995052622464179	0.0568667921893025	6	0.0232157706954465	0.949550548027763	1.04055469690059	0.908792012618548	0.968386165015233	1.01837345319633	1.06121300983227	NA	NA	1.04433387224189	0.969217221880804	0.695096618008723	0.666851994626987	0.666704100478202	0.723233830233651	0.744610219521012	NA	NA	0.700556495707643	0.689636740309803	NA	NA	p.Ser106Gly	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.245	-2.906	0.661	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106H	106	S	H	missense	possibly_wt-like	0.82891825452789	0.272255766919775	6	0.111147951413926	0.611072272801187	1.04676423625459	1.08315608883232	0.998307106038468	0.833548951471216	1.04923009965605	NA	NA	0.408699341298891	0.600567939870393	0.670552463244264	0.703991328367405	0.673173360083638	0.667931566404889	0.740641433266555	NA	NA	0.56980324721748	0.606726972179228	NA	NA	p.Ser106His	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.245	-3.624	1.379	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106I	106	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser106Ile	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.245	-3.5	1.255	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106K	106	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser106Lys	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.245	-2.916	0.671	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106L	106	S	L	missense	possibly_wt-like	0.883235104807886	0.338011540889416	6	0.13799263372516	0.612774512574745	1.15369569704103	1.30385477207063	1.1798633599693	0.73207880423436	0.989822382528071	NA	NA	0.395415859859742	0.698375450185218	0.674999067510134	0.75099987640576	0.71242795902011	0.637570176000159	0.72096536729603	NA	NA	0.567070767679512	0.628724025740293	NA	NA	p.Ser106Leu	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.245	-3.184	0.939	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106M	106	S	M	missense	possibly_wt-like	0.755643265745328	0.235258323955854	6	0.0960438085723713	0.567400860005421	0.943885671485235	0.353614163703473	0.699926561469769	0.705442715502975	1.00372833055526	NA	NA	0.969747556032706	0.801400267207788	0.640747358959656	0.54859979575739	0.608659974541144	0.629600258631843	0.725571071133734	NA	NA	0.685213711981282	0.651894459287469	NA	NA	p.Ser106Met	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.245	-4.011	1.766	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106N	106	S	N	missense	low	0.633578656850373	0.100040591519497	6	0.0408414004648283	0.553530982861132	0.713626330839614	0.491188703997496	0.574000741059666	0.660325049936611	0.691358361461998	NA	NA	0.604932430533722	0.779666654112743	0.613134882819056	0.57790300360337	0.581433330077395	0.616100376196343	0.622112927710224	NA	NA	0.610169389441769	0.647006537595276	NA	NA	p.Ser106Asn	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.245	-2.979	0.734	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106P	106	S	P	missense	wt-like	1.02095189920004	0.237979005766882	6	0.0971545222706193	0.830532534614436	1.21137126378565	0.857753108887236	1.13555707489125	1.15562870279298	1.17139714988329	NA	NA	1.19820195839521	0.607173400350301	0.717528180270621	0.655980770917475	0.702848418720902	0.764302660146504	0.781103633396502	NA	NA	0.732207941820339	0.608212549999422	NA	NA	p.Ser106Pro	1	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.245	-2.688	0.443	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106Q	106	S	Q	missense	wt-like	0.917939645935439	0.229900206385562	6	0.0938563662341951	0.733984548396615	1.10189474347426	1.10764234269589	1.15535272501966	0.881846682923956	0.877610324637403	NA	NA	0.974429397040455	0.510756403295266	0.684988544806542	0.709206870318701	0.70712847126469	0.68238297226396	0.68380029917889	NA	NA	0.686176790434193	0.586528224924693	NA	NA	p.Ser106Gln	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.245	-2.736	0.491	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106R	106	S	R	missense	wt-like	0.897247345371447	0.128912423038029	6	0.0526282763248297	0.794097819206359	1.00039687153654	0.924710673532251	0.90847793190548	1.04573537326017	1.00144755039974	NA	NA	0.693017615651482	0.81009492747956	0.662046275523287	0.670242649819343	0.653751235386526	0.73142092722625	0.724815667913853	NA	NA	0.628288959001525	0.653849901227232	NA	NA	p.Ser106Arg	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.245	-3.368	1.123	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106S	106	S	S	synonymous	wt-like	1.35805319996918	0.181341188908638	4	0.0906705944543188	1.18034210038188	1.53576429955648	1.6186934028408	1.20320847373691	1.32910681182869	1.28120411147032	NA	NA	NA	NA	0.816841018678665	0.818060117462606	0.717475447378308	0.816209913053243	0.817472124304087	NA	NA	NA	NA	NA	NA	p.Ser106=	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106T	106	S	T	missense	wt-like	1.29298970164562	0.194217741469159	6	0.0792890609325368	1.13758599784985	1.44839340544139	1.27368952311984	1.01456625053779	1.28705024316968	1.29861048267875	NA	NA	1.62398483922943	1.26003687113823	0.779334232897122	0.744574715486875	0.676688778487314	0.803625956737907	0.823237181854888	NA	NA	0.819793641008174	0.755042509056336	NA	NA	p.Ser106Thr	1	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.245	-2.179	-0.066	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106V	106	S	V	missense	wt-like	1.05380516640688	0.0667373905795215	6	0.0272454256141088	1.00040511345976	1.107205219354	0.987204370033703	1.00149174260864	1.09434253305372	1.16672486899691	NA	NA	1.02924352303921	1.04382396070912	0.701934120195457	0.683553730297837	0.673861915991869	0.745964918687229	0.779556155873418	NA	NA	0.697452334301916	0.706415906088998	NA	NA	p.Ser106Val	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.245	-2.811	0.566	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106W	106	S	W	missense	wt-like	0.935896986651757	0.168075456916489	6	0.0686165179550894	0.801411082715236	1.07038289058828	1.11998169022926	1.09642977268717	0.943160700257608	0.837175669481098	NA	NA	0.950287286327571	0.668346800927833	0.687799635613387	0.71183513616412	0.694388635473377	0.700729046141275	0.670408184806998	NA	NA	0.681210635753397	0.621970538160914	NA	NA	p.Ser106Trp	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.245	-5.883	3.638	0.009041106	NA	NA	NA	NA	NA	NA	NA
S106X	106	S	X	nonsense	low	-0.22836256658717	0.271129054820801	6	0.110687973125675	-0.44530700743523	-0.0114181257391097	0.260456627396335	-0.0934406121898315	-0.31030106311134	-0.36303882194322	NA	NA	-0.395325755808373	-0.468525773866591	0.385348710684206	0.528757355121257	0.437124654015995	0.325674480918141	0.272892497389298	NA	NA	0.404411204783238	0.366286216585174	NA	NA	p.Ser106Ter	0	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S106Y	106	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser106Tyr	1	4.5	18.5	27.4	0.499	31	173.8	-74.1	154.9	57.3426573426573	-3.8	0	0	18.09	0	0	0	0	5	21.9683069072676	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.245	-4.709	2.464	0.009041106	NA	NA	NA	NA	NA	NA	NA
Y107A	107	Y	A	missense	low	0.537407703420483	0.228513267250404	6	0.0932901507032894	0.354562367929722	0.720253038911244	0.85289642460816	0.78951154138634	0.452342761865537	0.470119870073045	NA	NA	0.326157919925073	0.333417702664745	0.553346506624502	0.654946303140458	0.628029301574608	0.553868955257777	0.548837882611104	NA	NA	0.552824057991226	0.546644489170017	NA	NA	p.Tyr107Ala	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.805	-2.391	0.586	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107C	107	Y	C	missense	possibly_wt-like	0.887574471320451	0.334622614184897	6	0.136609110191533	0.619825535384983	1.15532340725592	0.456808047470305	0.677155098018898	0.824763098697887	0.982211338216829	NA	NA	0.935872046738711	1.44863719878008	0.671774027631213	0.570579966056274	0.603736516133035	0.665302707441407	0.718444559946204	NA	NA	0.67824534782102	0.797459001362687	NA	NA	p.Tyr107Cys	1	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.805	-5.334	3.529	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107D	107	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr107Asp	1	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.805	-4.233	2.428	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107E	107	Y	E	missense	possibly_low	0.445601809322837	0.576456300667314	5	0.257799094870034	-0.0596751318694549	0.950878750515129	0.216123993775777	0.263352211982356	NA	-0.185225199563887	NA	NA	0.578336933406198	1.35542110701374	0.519314558695651	0.519314558695651	0.514267461895401	NA	0.331785057708638	NA	NA	0.604698560725973	0.77649456461609	NA	NA	p.Tyr107Glu	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.805	-4.086	2.281	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107F	107	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr107Phe	1	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.805	-2.156	0.351	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107G	107	Y	G	missense	low	0.202395185847538	0.239971237238203	6	0.0979678473629946	0.0103817333731518	0.394408638321925	0.565606924482969	0.448980067867906	0.0412759854771695	0.0816695060703963	NA	NA	0.017278787599148	0.0595598435876415	0.487169752591371	0.593753993021566	0.554402389095433	0.430871608548419	0.420181617770541	NA	NA	0.489286053090011	0.485053452092731	NA	NA	p.Tyr107Gly	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.805	-3.27	1.465	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107H	107	Y	H	missense	possibly_low	0.632663671689154	0.158992436587034	6	0.0649083904333409	0.505445564145341	0.759881779232966	0.826052240310691	0.788178432380935	0.663763688369767	0.596047246662676	NA	NA	0.50306375481899	0.418876667591864	0.603837392899743	0.649228524907339	0.627741067717538	0.617129268405261	0.590545517394225	NA	NA	0.589214485923025	0.565864336630852	NA	NA	p.Tyr107His	1	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.805	-2.993	1.188	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107I	107	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr107Ile	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.805	-3.088	1.283	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107K	107	Y	K	missense	low	0.461963680473206	0.283817773029103	6	0.115868120642392	0.234866337057776	0.689061023888637	0.726947650676112	0.780546699008102	0.397771857159544	0.536024592179465	NA	NA	0.0146431857035252	0.31584809811249	0.556679420470443	0.6281193692282	0.626090997140213	0.537540521845234	0.570665781790288	NA	NA	0.488743896405937	0.542693059150598	NA	NA	p.Tyr107Lys	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.805	-4.116	2.311	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107L	107	Y	L	missense	low	0.4997580656321	0.146374036649555	6	0.0597569502304755	0.382636595354415	0.616879535909784	0.651393089111922	0.659177855805615	0.574802564363848	0.418438869526244	NA	NA	0.351175572064439	0.343560442920531	0.57424054070489	0.612026340558102	0.599849624782352	0.590510765423467	0.531720935094151	NA	NA	0.557970315986314	0.548925606437437	NA	NA	p.Tyr107Leu	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.805	-2.901	1.096	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107M	107	Y	M	missense	possibly_wt-like	0.898167698757662	0.269639633903419	6	0.110079919582373	0.682415020955145	1.11392037656018	1.08110888712473	1.05994943209116	1.15106174255826	0.503251494133649	NA	NA	0.618731878260442	0.974902758377729	0.68870829117315	0.703555276922043	0.686501156479082	0.762936157126405	0.559811204802945	NA	NA	0.613008005863318	0.690915425867218	NA	NA	p.Tyr107Met	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.805	-3.755	1.95	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107N	107	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr107Asn	1	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.805	-3.73	1.925	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107P	107	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr107Pro	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.805	-2.03	0.225	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107Q	107	Y	Q	missense	low	0.019055693392111	0.270209475867789	6	0.110312556590161	-0.197152944567142	0.235264331351364	0.409131089852751	0.29240113148267	-0.118127686630472	-0.0388966523487735	NA	NA	-0.158668623226095	-0.271505098777415	0.431844617662205	0.560424832733311	0.520548180184274	0.383175638328619	0.380249639206916	NA	NA	0.453092777852583	0.410596457471827	NA	NA	p.Tyr107Gln	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.805	-3.807	2.002	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107R	107	Y	R	missense	possibly_low	0.585076114181774	0.212316397273986	6	0.0866778062245511	0.415190735722712	0.754961492640836	0.812459874790092	0.814520610799384	0.613592617372275	0.566644688282924	NA	NA	0.42539671900082	0.277842174845149	0.591462303722778	0.646333367772034	0.633436556727369	0.602117331248782	0.580807276196774	NA	NA	0.573237982540238	0.534145470861535	NA	NA	p.Tyr107Arg	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.805	-4.407	2.602	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107S	107	Y	S	missense	low	0.4993165414161	0.242781032733019	6	0.0991149415703063	0.305054825608508	0.693578257223692	0.790862846739851	0.76572436320223	0.261403369649379	0.555267824087813	NA	NA	0.246812792001985	0.375828052815342	0.566610927144991	0.641733227364811	0.622886233686661	0.496737024452703	0.577039214718187	NA	NA	0.536502362547116	0.556182639571795	NA	NA	p.Tyr107Ser	1	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.805	-3.488	1.683	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107T	107	Y	T	missense	low	0.220520785360196	0.450509262814993	6	0.183919636382356	-0.139955077998924	0.580996648719317	0.850176141831825	0.696711464919877	0.0853587597604123	0.0545687655799856	NA	NA	-0.286640042269916	-0.0770503776610055	0.449195723752451	0.654366886255441	0.607964832826796	0.444061835985587	0.411205747571882	NA	NA	0.42676840757482	0.454329611519315	NA	NA	p.Tyr107Thr	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.805	-3.982	2.177	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107V	107	Y	V	missense	possibly_wt-like	0.736328635538844	0.15374628200266	6	0.062766656792761	0.613308248795046	0.859349022282642	0.81636969851736	0.989979274010821	0.730157708708104	0.557329926282379	NA	NA	0.708631310747117	0.615503894967281	0.634248065354857	0.647166155416291	0.671372784784369	0.636995355396605	0.577722190950565	NA	NA	0.631500775313109	0.610086090545439	NA	NA	p.Tyr107Val	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.805	-2.73	0.925	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107W	107	Y	W	missense	possibly_low	0.680711878588546	0.193940629782197	6	0.0791759305600671	0.525529906248371	0.835893850928722	0.871663453558658	0.893981570069664	0.622295016091494	0.402009414517623	NA	NA	0.753883553016116	0.540438264277723	0.622765305341923	0.658943657220746	0.65061695134187	0.604721219507218	0.526279435971857	NA	NA	0.640809391176627	0.593203719308729	NA	NA	p.Tyr107Trp	0	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.805	-4.104	2.299	0.008074748	NA	NA	NA	NA	NA	NA	NA
Y107X	107	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr107Ter	1	4.5	19.5	23.8	0.943	21.5	-151.1	-151.8	171.1	28.2352941176471	-1	0	1	16.24	0	0	0	0	6	20.3861940629412	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S108A	108	S	A	missense	wt-like	0.893115966061694	0.16504957335207	6	0.0673812061627727	0.761051228747792	1.0251807033756	1.06089090778795	0.990631382491172	0.639205440894949	1.03788870535178	NA	NA	0.7935035816318	0.83657577821251	0.665659630995071	0.699248872194358	0.671513778312849	0.609781072314656	0.736885119553174	NA	NA	0.648959432111452	0.659805483677294	NA	NA	p.Ser108Ala	1	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.215	-2.646	0.431	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108C	108	S	C	missense	possibly_low	0.683917948027014	0.151555672173045	6	0.0618723440747474	0.562650382001439	0.805185514052589	0.79543234637633	0.613664179396976	0.816722053553279	0.788752731621804	NA	NA	0.422085954004552	0.666850423209143	0.632170262883806	0.642706525166233	0.590009032267009	0.662896706094748	0.65437032026907	NA	NA	0.5725569413803	0.621634000601379	NA	NA	p.Ser108Cys	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.215	-3.656	1.441	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108D	108	S	D	missense	possibly_low	0.445073776750854	0.486003029756369	6	0.198409906058296	0.0561975067006185	0.833950046801089	1.071790289028	1.02780340221215	0.00734771452769211	0.243836559004803	NA	NA	-0.00421254332351635	0.323877239055992	0.514682001036743	0.701570426990668	0.679550806474718	0.42071976085621	0.473891973698024	NA	NA	0.484865177263227	0.54449882481026	NA	NA	p.Ser108Asp	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.215	-2.778	0.563	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108E	108	S	E	missense	wt-like	0.947066798455526	0.135484493222122	6	0.0553113127422943	0.838658617542998	1.05547497936805	1.02586281737297	1.0292484383374	0.915572442888142	1.11942713505616	NA	NA	0.831941860163082	0.760348096915391	0.685825586159017	0.691787932025602	0.679863240292432	0.692474225631107	0.763890963230692	NA	NA	0.656866381057222	0.642661765542243	NA	NA	p.Ser108Glu	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.215	-2.748	0.533	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108F	108	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser108Phe	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.215	-4.02	1.805	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108G	108	S	G	missense	wt-like	0.841228671312978	0.102481013225965	6	0.0418376984545048	0.759228289146101	0.923229053479854	0.900574915158961	0.992054564668852	0.789855635827181	0.882333003080808	NA	NA	0.710197078690902	0.772356830451162	0.659979816905958	0.665101762976317	0.671821487049887	0.6548578708356	0.685364468568025	NA	NA	0.631822861724507	0.645362547454967	NA	NA	p.Ser108Gly	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.215	-3.003	0.788	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108H	108	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser108His	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.215	-3.414	1.199	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108I	108	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser108Ile	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.215	-3.498	1.283	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108K	108	S	K	missense	possibly_wt-like	0.730814238404333	0.252392708261445	6	0.103038891673279	0.528861721717781	0.932766755090884	0.884131319597411	1.06304605465947	0.837946451518141	0.715322225387805	NA	NA	0.498501783068654	0.385937596194512	0.645824574796388	0.661599297349716	0.687170682724226	0.669247364394399	0.630049852243061	NA	NA	0.58827606518463	0.558456290812621	NA	NA	p.Ser108Lys	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.215	-2.664	0.449	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108L	108	S	L	missense	wt-like	1.0915335264959	0.101801593982187	6	0.0415603267097242	1.01007678295913	1.17299027003268	1.12088630981687	1.03377305467403	0.998855486537332	1.13628256114685	NA	NA	1.26030551823682	0.999098228563527	0.714710790402843	0.712027819023468	0.680841515597139	0.717393761782217	0.769473545624947	NA	NA	0.744982959219168	0.696357022856028	NA	NA	p.Ser108Leu	1	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.215	-3.529	1.314	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108M	108	S	M	missense	wt-like	0.889835044893924	0.116563897621152	6	0.04758701193364	0.796566215372112	0.983103874415736	0.910007202128913	0.723234442589906	0.851057804727957	1.07252406431397	NA	NA	0.84164180779276	0.940544947810042	0.670140653240789	0.667110828497835	0.613699412762746	0.673170477983742	0.748356484567666	NA	NA	0.658861709506234	0.683188303513673	NA	NA	p.Ser108Met	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.215	-4.241	2.026	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108N	108	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser108Asn	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.215	-2.941	0.726	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108P	108	S	P	missense	low	-0.233140453214244	0.165444190943056	6	0.0675423081196794	-0.365520944561523	-0.100759961866965	-0.270864112647826	0.100186394377294	-0.278336619866526	-0.288696837392325	NA	NA	-0.340968873366303	-0.320162670389776	0.407619994413862	0.415586691093459	0.478989091739842	0.335238721897907	0.297514850563584	NA	NA	0.415592691331105	0.399653297734265	NA	NA	p.Ser108Pro	1	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.215	-3.645	1.43	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108Q	108	S	Q	missense	possibly_low	0.575822926895943	0.222652263153746	6	0.090897405800427	0.397667285238984	0.753978568552903	0.481825956317873	0.612264499061991	0.844581041913044	0.821736785414999	NA	NA	0.363457244926453	0.331072033741301	0.582807577385058	0.575908749865148	0.589706404904968	0.671232533378977	0.665294766616876	NA	NA	0.560496718416369	0.546116944763873	NA	NA	p.Ser108Gln	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.215	-2.705	0.49	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108R	108	S	R	missense	wt-like	1.02312544668552	0.0878501855222326	6	0.0358646880563847	0.952831949778247	1.0934189435928	0.890638203135195	0.973976241051365	1.07804904407233	1.01835867773975	NA	NA	1.14775919728843	1.02997131682608	0.712566017954094	0.662985255538852	0.667912740709931	0.741089662333609	0.730416698777591	NA	NA	0.721831609893029	0.70330042601516	NA	NA	p.Ser108Arg	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.215	-2.864	0.649	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108S	108	S	S	synonymous	wt-like	1.15336165714693	0.328614015175283	6	0.134156109917775	0.890420513402097	1.41630280089177	1.11902380032528	1.02001257726406	1.28463908067914	1.47432613263809	NA	NA	0.586680435673715	1.43548791630131	0.753066407550331	0.711631106792916	0.677866338426385	0.802904500746189	0.881434885584282	NA	NA	0.606414861480817	0.794501708307747	NA	NA	p.Ser108=	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108T	108	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser108Thr	1	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.215	-2.078	-0.137	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108V	108	S	V	missense	wt-like	1.04153343098109	0.0711278187700869	6	0.0290378104173115	0.984620368373253	1.09844649358892	0.968618231806397	1.08113356329038	0.98613099227238	1.00861979464506	NA	NA	1.16092045937252	1.04377754449978	0.709995934604075	0.679594905719068	0.691081414972186	0.713586402193203	0.727191142982583	NA	NA	0.724538948289469	0.706405467014948	NA	NA	p.Ser108Val	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.215	-3.097	0.882	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108W	108	S	W	missense	wt-like	0.992541600166967	0.0951290850135086	6	0.0388362863301564	0.916423877666575	1.06865932266736	0.967883700482387	0.98403409502489	0.918618157633194	1.18152224150715	NA	NA	0.947362896842248	0.955828509511929	0.68361733655778	0.679438451450634	0.67008736711549	0.693385549177531	0.784457102951973	NA	NA	0.680609073996691	0.686625599118868	NA	NA	p.Ser108Trp	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.215	-5.807	3.592	0.007160109	NA	NA	NA	NA	NA	NA	NA
S108X	108	S	X	nonsense	low	-0.23778258718422	0.220450152936504	6	0.0899983980688249	-0.414176206065416	-0.0613889683030243	-0.519396228204128	-0.416755975029984	-0.00436051110550964	0.034185271217603	NA	NA	-0.293332203612157	-0.227035876371146	0.410835569696178	0.362649656210533	0.367220067291456	0.417216484088842	0.404454655303514	NA	NA	0.425391796027898	0.420597651285482	NA	NA	p.Ser108Ter	1	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S108Y	108	S	Y	missense	wt-like	0.874718413695005	0.183725262076282	6	0.0750055241576675	0.727710287704427	1.02172653968558	0.756935665426499	1.02450527385552	0.916303240835365	1.02196923459099	NA	NA	0.970051757852737	0.558545309608916	0.682057000072908	0.634506779480423	0.678837712306507	0.692692891341041	0.731612529188685	NA	NA	0.68527628783931	0.597276020553294	NA	NA	p.Ser108Tyr	0	2.2	20.2	20.8	0.868	21.9	-119.2	-142.3	173.9	48.2517482517483	-5.4	0	1	14.34	0	0	0	0	5	21.3345285481517	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.215	-3.621	1.406	0.007160109	NA	NA	NA	NA	NA	NA	NA
E109A	109	E	A	missense	wt-like	1.17087936132633	0.235956349330174	6	0.0963287762381376	0.982078429224763	1.3596802934279	0.987695310407431	0.96335738912253	1.19046845967222	0.993137400556979	NA	NA	1.5431767073519	1.34744090084692	0.748381559282341	0.683658299993513	0.665616819943737	0.774727238103876	0.722063314104687	NA	NA	0.803170998226742	0.774699804459995	NA	NA	p.Glu109Ala	1	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.949	-2.887	0.938	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109C	109	E	C	missense	wt-like	1.29285313221166	0.245106007078593	5	0.109614738704256	1.07801219217655	1.50769407224677	1.16202980394549	0.951657612296185	1.30359038979511	NA	NA	NA	1.51180951091847	1.53517834410304	0.796718606750125	0.720791332660395	0.663087190492694	0.808575016759214	NA	NA	NA	0.796718606750125	0.816922232793254	NA	NA	p.Glu109Cys	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.949	-4.322	2.373	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109D	109	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu109Asp	1	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.949	-3.157	1.208	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109E	109	E	E	synonymous	wt-like	1.18930642567234	0.0808596849983641	6	0.0330108281680286	1.12460639136316	1.25400645998152	1.11665047163164	1.06107783300173	1.21492583334293	1.24684009341437	NA	NA	1.25422017810437	1.24212414453899	0.74737254212801	0.71112559070071	0.686745130036727	0.782045251238887	0.806090628448513	NA	NA	0.743731173874365	0.751013910381655	NA	NA	p.Glu109=	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109F	109	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu109Phe	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.949	-4.681	2.732	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109G	109	E	G	missense	wt-like	0.885127150633148	0.0937568684590612	6	0.038276081267657	0.810107409879212	0.960146891387084	0.947416987665457	1.01554035542297	0.87877350807354	0.895735667689073	NA	NA	0.828570765910148	0.7447256190377	0.675989229112964	0.675079066797654	0.676899391428273	0.68146343224203	0.689803482988407	NA	NA	0.656172929863053	0.639148247188427	NA	NA	p.Glu109Gly	1	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.949	-3.373	1.424	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109H	109	E	H	missense	possibly_low	0.573973353892452	0.477424382369729	6	0.194907687928208	0.191961305243193	0.955985402541712	1.06269653293446	1.07067116430484	0.802828965958422	0.340696713899798	NA	NA	-0.0983751896993299	0.265321935956524	0.595034668244193	0.699633468129383	0.688819321173715	0.65873968584908	0.505972432092403	NA	NA	0.465495443083112	0.531329650639305	NA	NA	p.Glu109His	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.949	-3.704	1.755	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109I	109	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu109Ile	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.949	-3.009	1.06	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109K	109	E	K	missense	wt-like	1.16200256240671	0.2565526336434	6	0.10473717409892	0.956721473330329	1.3672836514831	1.27546480032897	0.748349784816469	1.14305754791408	1.11374357994304	NA	NA	1.53926733001966	1.15213233141806	0.752747014675456	0.74495284734857	0.619129645348574	0.760541182002341	0.762008547767528	NA	NA	0.802366819471686	0.730774618665645	NA	NA	p.Glu109Lys	1	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.949	-2.697	0.748	0.008292133	NA	NA	NA	NA	8.13e-06	NA	NA
E109L	109	E	L	missense	possibly_low	0.649760596776808	0.400755493898362	6	0.163607745278007	0.32909530844011	0.970425885113505	0.874991283223737	0.977088989599248	0.740377885215712	0.902957497582078	NA	NA	-0.0909063007365483	0.494054225776619	0.649852933193082	0.659652480845694	0.668585753581654	0.64005338554047	0.692195381015671	NA	NA	0.467031831443019	0.582771880526583	NA	NA	p.Glu109Leu	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.949	-3.089	1.14	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109M	109	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu109Met	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.949	-3.916	1.967	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109N	109	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu109Asn	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.949	-3.705	1.756	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109P	109	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu109Pro	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.949	-2.803	0.854	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109Q	109	E	Q	missense	wt-like	0.901539820935285	0.106189808411407	6	0.0433518077486419	0.816571839083242	0.986507802787328	0.859260891929637	1.10690909399195	0.874082053325498	0.863691774890625	NA	NA	0.904849184613014	0.800445926860987	0.675527104630828	0.656301926850715	0.696654388076437	0.680059678595758	0.679190421602856	NA	NA	0.671863787658799	0.651679826733624	NA	NA	p.Glu109Gln	1	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.949	-2.563	0.614	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109R	109	E	R	missense	wt-like	1.06839218698863	0.147297303494289	6	0.0601338723414805	0.950531962948401	1.18625241102886	0.822882072636654	0.976581002667824	1.14015089284532	1.20619258025477	NA	NA	1.07112544051993	1.1934211330073	0.723064094196577	0.648553283092536	0.668475920828299	0.759671467197369	0.792628014681633	NA	NA	0.706067657254047	0.740060531139107	NA	NA	p.Glu109Arg	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.949	-2.458	0.509	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109S	109	E	S	missense	possibly_low	0.502025534381078	0.324410586575048	6	0.132440067377642	0.24244777221084	0.761603296551315	0.782995794209736	0.986755326054203	0.465953809662391	0.334127858310333	NA	NA	0.333058432060793	0.10926198598901	0.55609255665904	0.640057554853512	0.67067572929171	0.557941584964454	0.50379680168313	NA	NA	0.554243528353626	0.496231537343888	NA	NA	p.Glu109Ser	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.949	-2.891	0.942	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109T	109	E	T	missense	wt-like	0.953919813642015	0.199067491213534	6	0.0812689629748553	0.794635573150379	1.11320405413365	1.06310499134172	0.967302232213002	1.21173994894683	0.609073875616121	NA	NA	0.933209065832645	0.939088767901763	0.680279182818323	0.699720469267667	0.666469741448951	0.781091986829913	0.594859987349524	NA	NA	0.677697559135564	0.682860806501083	NA	NA	p.Glu109Thr	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.949	-2.912	0.963	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109V	109	E	V	missense	possibly_wt-like	0.85480023149564	0.237808258361336	6	0.0970848149342041	0.664517490778863	1.04508297221242	0.794874413397163	1.02572889987654	1.00301822259364	1.12563076493366	NA	NA	0.673920680878645	0.505628407294192	0.660844980390898	0.642587686128009	0.679102274653786	0.718639314863582	0.765945629469816	NA	NA	0.624360622612926	0.585374931048451	NA	NA	p.Glu109Val	1	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.949	-2.399	0.45	0.008292133	NA	NA	NA	NA	4.06e-06	NA	NA
E109W	109	E	W	missense	wt-like	1.05533378237359	0.0913224935325345	6	0.0372822518655544	0.982261911454549	1.12840565329263	0.929389867459171	0.994970680794083	1.18007562465603	1.06228094249852	NA	NA	1.13310595126555	1.03217962756817	0.711307220596415	0.671239312369689	0.672451985677555	0.771617545943854	0.744963922955667	NA	NA	0.71881736282943	0.7037970783634	NA	NA	p.Glu109Trp	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.949	-4.404	2.455	0.008292133	NA	NA	NA	NA	NA	NA	NA
E109X	109	E	X	nonsense	low	-0.0803568037026429	0.098952911708618	6	0.0403973570414649	-0.15953416857452	-0.00117943883076624	-0.206076252190868	-0.146070693390772	-0.050214315661628	-0.0950538051345294	NA	NA	0.0858172514807259	-0.0705430073187862	0.427565918349974	0.429386425672322	0.425745411027627	0.403496337823351	0.36165017273442	NA	NA	0.503384762903254	0.455793128722634	NA	NA	p.Glu109Ter	1	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E109Y	109	E	Y	missense	wt-like	1.20245523907379	0.3462535952809	5	0.154849315300358	0.898956158054401	1.50595432009318	0.667611205563507	NA	1.33525903572009	1.05615245016143	NA	NA	1.5220507400754	1.43120276384853	0.79353797119065	0.615480779411653	NA	0.818050750743053	0.742934142560896	NA	NA	0.798825279555982	0.79353797119065	NA	NA	p.Glu109Tyr	0	2.7	19.8	17.1	0.849	21.4	178.4	-123.5	151.6	42.5233644859813	-0.7	0	1	14.17	1	10	1	10	5	19.831363112942	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.949	-4.648	2.699	0.008292133	NA	NA	NA	NA	NA	NA	NA
E110A	110	E	A	missense	wt-like	0.909104831050643	0.13034248659465	6	0.0532120973270747	0.804811036747736	1.01339862535355	1.02003023458885	1.11254801958412	0.851248844015423	0.762385402759589	NA	NA	0.840959351331781	0.867457134024099	0.669989193012561	0.690545599067507	0.697873590157117	0.673227639804704	0.645637358841822	NA	NA	0.658721324749141	0.666750746220418	NA	NA	p.Glu110Ala	1	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.963	-2.634	0.671	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110C	110	E	C	missense	possibly_wt-like	0.837755314588116	0.317891978275135	6	0.129778856682999	0.583393429534652	1.09211719964158	0.95156590752078	1.31060344807703	0.663413350982175	0.376294287590339	NA	NA	0.752351627091556	0.97230326626682	0.658228523931689	0.675962781623065	0.740695504821882	0.617024442202799	0.517762486351126	NA	NA	0.640494266240313	0.690330796251239	NA	NA	p.Glu110Cys	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.963	-5.548	3.585	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110D	110	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu110Asp	1	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.963	-3.025	1.062	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110E	110	E	E	synonymous	wt-like	1.35181017839787	0.226375165770236	6	0.0924172744291723	1.17067564896734	1.5329447078284	1.1015622582818	1.18233859531366	1.31289067992536	1.3642345576064	NA	NA	1.7533286750718	1.39650630418819	0.798546244626923	0.707911819817885	0.712963134033985	0.811357803097965	0.844972129601651	NA	NA	0.846400324385614	0.785734686155881	NA	NA	p.Glu110=	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110F	110	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu110Phe	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.963	-4.016	2.053	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110G	110	E	G	missense	possibly_wt-like	0.796242095449799	0.126502021908334	6	0.0516442341842996	0.69502125643942	0.897462934460179	0.899794988964401	0.990937421752206	0.716395799440265	0.799178066515632	NA	NA	0.66968206357531	0.701464232450981	0.645350408616347	0.664935639656298	0.671579947603031	0.632877585674442	0.657823231558253	NA	NA	0.623488717525115	0.629418697434928	NA	NA	p.Glu110Gly	1	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.963	-2.859	0.896	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110H	110	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu110His	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.963	-2.839	0.876	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110I	110	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu110Ile	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.963	-3.687	1.724	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110K	110	E	K	missense	wt-like	1.21291810051355	0.148357700301909	6	0.0605667775254044	1.09420939790411	1.331626803123	1.03660372230816	1.32034998739498	1.09960597382292	1.10392839863879	NA	NA	1.37094244990495	1.34607807101152	0.753148770421277	0.694075731563926	0.742802821334871	0.747539819132506	0.758757721710049	NA	NA	0.76774153748132	0.774393302016703	NA	NA	p.Glu110Lys	1	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.963	-2.721	0.758	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110L	110	E	L	missense	wt-like	1.05546410690366	0.112597151907403	6	0.045967594777297	0.965369276684222	1.14555893712309	0.904313849107618	1.01898889255204	1.10113154022995	1.22254673123658	NA	NA	0.976208444255004	1.10959518404074	0.703875350427058	0.66589815130795	0.677645005743331	0.747996291489485	0.798044572818633	NA	NA	0.686542749473855	0.721207951380261	NA	NA	p.Glu110Leu	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.963	-3.971	2.008	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110M	110	E	M	missense	wt-like	1.0918348215485	0.444361584315956	6	0.181409857144803	0.736278035104133	1.44739160799287	1.07373042331895	0.234894985365516	1.27492634182147	1.12573639507621	NA	NA	1.39416804564298	1.44755273806589	0.769249887481547	0.701983673207993	0.508114674571897	0.799998303560245	0.765980614582084	NA	NA	0.77251916038101	0.797215104545989	NA	NA	p.Glu110Met	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.963	-5.146	3.183	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110N	110	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu110Asn	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.963	-3.67	1.707	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110P	110	E	P	missense	low	0.193955572558625	0.322084712666158	6	0.131490533330503	-0.0637611370771251	0.451672282194375	-0.0673819997605029	0.227691941308873	0.751938361682638	0.287643125559531	NA	NA	-0.158110910404021	0.121952916965231	0.493743312325829	0.458928130825934	0.506557291670216	0.643512453540615	0.488400878182877	NA	NA	0.453207502210151	0.499085746468782	NA	NA	p.Glu110Pro	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.963	-2.284	0.321	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110Q	110	E	Q	missense	wt-like	1.27425618766185	0.227141281232093	6	0.0927300397567734	1.0925086494536	1.45600372587009	1.19791484501514	1.14039181312603	1.17944875434433	1.08426355612679	NA	NA	1.33925274281971	1.70426541453908	0.756733726822298	0.728434802264423	0.703893746029986	0.771429976941691	0.752244649717524	NA	NA	0.761222803927072	0.854950164727038	NA	NA	p.Glu110Gln	1	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.963	-2.582	0.619	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110R	110	E	R	missense	wt-like	0.838467375832027	0.0800015741928077	6	0.0326605058986317	0.774453960553851	0.902480791110203	0.725078423037185	0.959227495797317	0.789599463706514	0.821999146653108	NA	NA	0.856915308904623	0.877984416893414	0.663363717294441	0.62772122604053	0.664723888399812	0.654781220293759	0.665381661674938	NA	NA	0.66200354618907	0.669118347689706	NA	NA	p.Glu110Arg	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.963	-3.02	1.057	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110S	110	E	S	missense	wt-like	1.26841803574128	0.226399388935479	6	0.0924271634949724	1.08726412409794	1.44957194738462	1.18310301083705	0.850656120541305	1.39189207143689	1.32856583202325	NA	NA	1.47605366502783	1.38023751458139	0.785719629574854	0.725279899805195	0.641249479232504	0.834996204692076	0.833158509560558	NA	NA	0.789363447810318	0.78207581133939	NA	NA	p.Glu110Ser	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.963	-2.611	0.648	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110T	110	E	T	missense	wt-like	1.0383850231159	0.160642149333546	6	0.0655818828418609	0.90984689470753	1.16692315152428	0.949592414230258	0.751007828275418	1.14556985063854	1.08633663413193	NA	NA	1.16201472771572	1.13578868370356	0.725931476495292	0.675542429979867	0.619704345628392	0.761292900669449	0.752931261180866	NA	NA	0.724764044840439	0.727098908150145	NA	NA	p.Glu110Thr	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.963	-2.644	0.681	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110V	110	E	V	missense	wt-like	0.955386325198953	0.238705637443745	5	0.106752406387327	0.746155453416808	1.1646171969811	1.18240850532864	0.867941635135591	0.608356855109007	NA	NA	NA	0.943379290149163	1.17484534027236	0.679789625885439	0.725131970986247	0.644986810930633	0.600550712627737	NA	NA	NA	0.679789625885439	0.735882807910957	NA	NA	p.Glu110Val	1	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.963	-3.474	1.511	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110W	110	E	W	missense	wt-like	0.871586930843898	0.171340374421507	6	0.0699494149450183	0.734488596812015	1.00868526487578	0.797786864679346	0.88566502851938	1.00885402400347	1.10063357569536	NA	NA	0.825153340609489	0.61142875155635	0.652144382656977	0.643208034668376	0.648818817176691	0.720385474199635	0.757666463591906	NA	NA	0.655469948137264	0.609169584772102	NA	NA	p.Glu110Trp	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.963	-5.804	3.841	0.008433921	NA	NA	NA	NA	NA	NA	NA
E110X	110	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu110Ter	1	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E110Y	110	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu110Tyr	0	2.7	22	13.9	0.962	35.2	-101.4	-138.7	158.5	41.1214953271028	-5.1	0	1	14.78	0	0	1	12	5	20.703281672437	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.963	-3.428	1.465	0.008433921	NA	NA	NA	NA	NA	NA	NA
P111A	111	P	A	missense	wt-like	1.21206804016157	0.161643935407155	6	0.0659908602938219	1.08272833067687	1.34140774964628	0.979604115846401	1.15157959785689	1.21201167317907	1.29921722870459	NA	NA	1.46359360859769	1.16640201678481	0.757578591391063	0.681934885505357	0.706312676764065	0.781173290796862	0.823438138488286	NA	NA	0.786800350975107	0.733983891985265	NA	NA	p.Pro111Ala	1	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.035	-2.625	0.59	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111C	111	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro111Cys	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.035	-4.422	2.387	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111D	111	P	D	missense	wt-like	1.11119290933959	0.100749461838508	6	0.041130795560725	1.03057803138509	1.19180778729409	1.05891356324243	1.2350253865818	1.15911629395151	1.09826688700614	NA	NA	0.94713765273202	1.16869767252364	0.72942741337932	0.698827700238583	0.724354638406333	0.765346199745289	0.756882607132983	NA	NA	0.680562740140235	0.734500188352308	NA	NA	p.Pro111Asp	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.035	-2.733	0.698	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111E	111	P	E	missense	wt-like	1.10441293302803	0.123615928273726	6	0.0504659913918524	1.00550140745589	1.20332445860017	0.950959097190862	0.96447052540961	1.14783480215172	1.21606714037475	NA	NA	1.1051837761466	1.24196225689464	0.732025565664981	0.675833531769257	0.665857493110124	0.761970608143144	0.79589850723283	NA	NA	0.713073629718677	0.750977501611284	NA	NA	p.Pro111Glu	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.035	-2.635	0.6	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111F	111	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro111Phe	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.035	-4.776	2.741	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111G	111	P	G	missense	wt-like	0.995813779914155	0.0457481766327993	6	0.0186766149021792	0.95920828735276	1.03241927247555	0.961245728970878	0.950430459852451	0.987034243408173	1.07937816336167	NA	NA	1.00665686980778	0.990137214083976	0.693573911289772	0.678024571684351	0.662821865691318	0.713856668484463	0.75062658871492	NA	NA	0.692806145118095	0.69434167746145	NA	NA	p.Pro111Gly	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.035	-3.423	1.388	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111H	111	P	H	missense	wt-like	1.223737088931	0.425936938973263	5	0.190484789934479	0.850393761056741	1.59708041680526	0.62171264395473	NA	1.1945961089993	1.09998851261538	NA	NA	1.77746829370416	1.42491988538142	0.775962292709452	0.605704442250874	NA	0.775962292709452	0.757452816201795	NA	NA	0.851365966432801	0.792124942541688	NA	NA	p.Pro111His	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.035	-3.318	1.283	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111I	111	P	I	missense	wt-like	1.2433275155365	0.386173455126784	6	0.157654652878033	0.934330073900394	1.55232495717261	0.697342640972882	0.82429778289892	1.4983580719146	1.32444275501413	NA	NA	1.52166462607064	1.59385921634784	0.814432750798198	0.62181353857987	0.63555049640827	0.866852429339004	0.831792930488431	NA	NA	0.798745853945899	0.830119647650497	NA	NA	p.Pro111Ile	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.035	-3.284	1.249	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111K	111	P	K	missense	possibly_wt-like	0.826930526250542	0.353041184452683	6	0.144128460016145	0.544443935471676	1.10941711702941	1.24000167326251	1.28617002084195	0.602941358679651	0.448898582469458	NA	NA	0.76942013148566	0.61415139076402	0.626893627279486	0.737399244908208	0.735412710283052	0.598930314847656	0.541809309976876	NA	NA	0.644005344206903	0.609781910352068	NA	NA	p.Pro111Lys	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.035	-2.723	0.688	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111L	111	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro111Leu	1	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.035	-3.102	1.067	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111M	111	P	M	missense	wt-like	1.01233532535899	0.157591780743645	6	0.0643365750797492	0.886237955314022	1.13843269540395	0.761976183365738	0.879553065187497	1.0928438252586	1.10361073256948	NA	NA	1.06006493864554	1.17596320712707	0.719963336855444	0.635580403600912	0.647497338769239	0.74551648282989	0.758652509477724	NA	NA	0.703792455892878	0.736134217818009	NA	NA	p.Pro111Met	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.035	-3.678	1.643	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111N	111	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro111Asn	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.035	-3.089	1.054	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111P	111	P	P	synonymous	wt-like	0.866009765353465	0.177057469215511	6	0.0722834091210902	0.724336886796354	1.00768264391058	1.19098800720695	0.912722001077042	0.686783845195904	0.843374729109335	NA	NA	0.75028479601038	0.811905213521176	0.654462945162281	0.726959394332295	0.654668853092231	0.624017244697884	0.67246133736187	NA	NA	0.64006910859895	0.654257037232331	NA	NA	p.Pro111=	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111Q	111	P	Q	missense	wt-like	0.993590897637842	0.158095862338577	6	0.0645423655291342	0.86709018572372	1.12009160955197	0.837929314372559	0.980514833544068	0.806343289150704	1.01704648655802	NA	NA	1.22939052547512	1.09032093672659	0.693099803024303	0.651758327071993	0.669326461363188	0.659791224073423	0.729982095976712	NA	NA	0.738623588332496	0.716873144685417	NA	NA	p.Pro111Gln	1	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.035	-2.694	0.659	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111R	111	P	R	missense	wt-like	1.09827620574005	0.0787929641934672	6	0.0321670929325633	1.03522986210488	1.16132254937523	1.00235115380377	1.03729492403554	1.05431035360153	1.14185951889756	NA	NA	1.20789585520026	1.14594542890166	0.731684932572079	0.68677997660812	0.68160298520394	0.733986689994378	0.771320655628881	NA	NA	0.734202025584021	0.729383175149781	NA	NA	p.Pro111Arg	1	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.035	-2.93	0.895	0.007888796	NA	NA	NA	NA	1.63e-05	NA	NA
P111S	111	P	S	missense	possibly_wt-like	0.817063101440173	0.215555127789104	6	0.0880000124206214	0.644586246456678	0.989539956423668	0.812058017258493	0.853727792403538	0.579396086583114	0.565487180733324	NA	NA	1.10279073833333	0.988918793329243	0.644080691726741	0.646247772612146	0.641913610841335	0.591885216187851	0.580423905213872	NA	NA	0.712581369697214	0.694067652833734	NA	NA	p.Pro111Ser	1	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.035	-2.637	0.602	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111T	111	P	T	missense	possibly_wt-like	0.950538741239602	0.299567419943175	6	0.122297887070471	0.710839287196132	1.19023819528307	1.1213367184211	1.16841687921356	0.791461544646504	0.412667180595077	NA	NA	1.17514839868001	1.03420172588136	0.707102473211001	0.712123755502101	0.709953095160716	0.655338382847709	0.529809329369152	NA	NA	0.727465707603527	0.704251851261287	NA	NA	p.Pro111Thr	1	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.035	-2.59	0.555	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111V	111	P	V	missense	wt-like	1.07058018353542	0.0824877162930716	6	0.0336754691609146	1.00457747681754	1.1365828902533	1.07951271307514	1.12045465966828	0.983284042815248	1.17083410761605	NA	NA	0.95984023999395	1.10955533804386	0.707974923007999	0.703215293813006	0.699583098800962	0.712734552202991	0.7809171516172	NA	NA	0.683175726798249	0.721198989956698	NA	NA	p.Pro111Val	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.035	-3.022	0.987	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111W	111	P	W	missense	possibly_wt-like	0.727738029724963	0.12437918742387	6	0.0507775906350794	0.628215780858489	0.827260278591437	0.738719032003854	0.681557485468851	0.880582364780235	0.833793964136153	NA	NA	0.527946132788271	0.703829199172414	0.630288620457426	0.630626658970502	0.604688364113864	0.682004669306858	0.669288150901021	NA	NA	0.594332917334889	0.629950581944349	NA	NA	p.Pro111Trp	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.035	-5.938	3.903	0.007888796	NA	NA	NA	NA	NA	NA	NA
P111X	111	P	X	nonsense	low	0.0100004329565478	0.0808437659119083	6	0.0330043292281973	-0.0546868636646215	0.0746877295777171	0.0265006084455045	0.116970117216465	0.0727729702578135	-0.0914961846543895	NA	NA	-0.0719383821293695	0.00719346860326257	0.472104902774719	0.478925010884582	0.482617930154649	0.440295978942449	0.362828470414409	NA	NA	0.47093362855166	0.473276176997777	NA	NA	p.Pro111Ter	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P111Y	111	P	Y	missense	possibly_wt-like	0.765384978733409	0.217528356517928	6	0.0888055796758577	0.591329240942525	0.939440716524292	0.780479180725633	0.643387756630491	0.548300150957046	1.04187994714905	NA	NA	0.56915562945787	1.00910720748036	0.621165719595614	0.639521519277198	0.596435619498222	0.58258084571779	0.738207034292603	NA	NA	0.602809919914029	0.698608057000712	NA	NA	p.Pro111Tyr	0	3.2	21.2	10.3	0.486	19.3	-131.7	-72.6	149.7	56.4935064935065	-1.3	0	1	14.72	0	0	0	0	5	20.1870935187693	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.035	-4.738	2.703	0.007888796	NA	NA	NA	NA	NA	NA	NA
I112A	112	I	A	missense	possibly_low	0.717710917381715	0.186364595067779	6	0.0760830273394108	0.568590923961693	0.866830910801736	0.755750766957168	1.01396471545916	0.614411921280867	0.636960106000203	NA	NA	0.809872419299398	0.475305575293488	0.619175206203423	0.634254397564052	0.676558719523514	0.602362479270208	0.604096014842794	NA	NA	0.652326585081998	0.578555281335503	NA	NA	p.Ile112Ala	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.161	-2.625	0.464	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112C	112	I	C	missense	low	0.314871614113564	0.3890182149928	6	0.158816021230114	0.00359793233459144	0.626145295892536	0.862294214413721	0.731896346727522	-0.00220324596936288	-0.0619250863289567	NA	NA	0.134991787016464	0.224175668821994	0.517788004385185	0.656948020808398	0.615572218384071	0.417861970182916	0.372622532694544	NA	NA	0.513500214395095	0.522075794375274	NA	NA	p.Ile112Cys	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.161	-3.882	1.721	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112D	112	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile112Asp	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.161	-3.362	1.201	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112E	112	I	E	missense	possibly_low	0.376330925273568	0.545064530365543	6	0.222521662714221	-0.0598035194262751	0.812465369973412	0.807039871408205	1.21717687501171	-0.157622226970933	0.408854637974905	NA	NA	-0.0802658294745225	0.0628022236920448	0.50716463432869	0.645178913719082	0.720495580135811	0.371358279324171	0.528546600489193	NA	NA	0.469220630375815	0.485782668168186	NA	NA	p.Ile112Glu	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.161	-2.988	0.827	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112F	112	I	F	missense	possibly_wt-like	0.77837935765584	0.189631740755835	6	0.0774168339812562	0.626645151255461	0.930113564056219	1.07459387241761	0.850239694956212	0.748026449941145	0.838557393094815	NA	NA	0.619361477429643	0.539497258095613	0.641750696988605	0.702167586803841	0.641159443119862	0.642341950857347	0.670865817018617	NA	NA	0.613137517607272	0.592992085628222	NA	NA	p.Ile112Phe	1	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.161	-3.179	1.018	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112G	112	I	G	missense	possibly_low	0.686008685007192	0.208199299301691	6	0.0849970080156896	0.519417610502778	0.852599759511606	0.863004900447841	1.00509185148686	0.650658537726784	0.527169625732794	NA	NA	0.611039564190745	0.459087630458127	0.612316834271069	0.657099396059418	0.674640301903026	0.613208010716971	0.567732982612092	NA	NA	0.611425657825166	0.574907841583223	NA	NA	p.Ile112Gly	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.161	-4.074	1.913	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112H	112	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile112His	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.161	-2.872	0.711	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112I	112	I	I	synonymous	wt-like	1.20358240924476	0.1876426154695	6	0.0766047769835915	1.0534398053132	1.35372501317632	1.01082232424793	1.05716082571738	1.41068985321599	1.45368732755825	NA	NA	1.09436029308568	1.19477383164333	0.725605969695434	0.688584325491956	0.685898226960409	0.840620783022548	0.874599233417595	NA	NA	0.710847184330172	0.740364755060695	NA	NA	p.Ile112=	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112K	112	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile112Lys	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.161	-3.322	1.161	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112L	112	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile112Leu	1	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.161	-2.477	0.316	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112M	112	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile112Met	1	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.161	-3.222	1.061	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112N	112	I	N	missense	wt-like	1.26967507010497	0.305532477478901	6	0.12473311161195	1.02520266366593	1.514147476544	0.855240356191687	0.950167515798501	1.33641103549925	1.33804276089425	NA	NA	1.52177845510787	1.61641029713823	0.808582357758423	0.655445557684374	0.662765014092119	0.818395446360374	0.836297305102259	NA	NA	0.798769269156473	0.835191419035019	NA	NA	p.Ile112Asn	1	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.161	-3.552	1.391	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112P	112	I	P	missense	low	0.389307205543592	0.358444150255504	6	0.146334211568581	0.102497421163108	0.676116989924076	0.837343357080028	0.765585841803295	0.313558595647049	0.399152842743496	NA	NA	-0.0476048973343808	0.0678074933220652	0.51883798944577	0.651633518889496	0.622856283729876	0.512342650553412	0.525333328338127	NA	NA	0.475939149852258	0.486908360702274	NA	NA	p.Ile112Pro	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.161	-3.75	1.589	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112Q	112	I	Q	missense	possibly_low	0.612664743776088	0.44069902949946	6	0.179914625402238	0.260038557695686	0.965290929856489	1.09150762361002	1.07351884335398	0.494018501061814	0.656737563379804	NA	NA	0.443885489849191	-0.0836795585982923	0.593843800919534	0.705770195001456	0.68943502290006	0.566338961684301	0.610646385315572	NA	NA	0.577041216523496	0.452838698933215	NA	NA	p.Ile112Gln	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.161	-3.128	0.967	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112R	112	I	R	missense	possibly_low	0.584183909606058	0.22012085992059	6	0.0898639647580165	0.408053775172369	0.760314044039747	0.826469324217003	0.890005691405001	0.393997836068547	0.540501741217456	NA	NA	0.391114148326702	0.463014716401639	0.573969839951472	0.64931736326631	0.649757319580241	0.536411278113361	0.572148630889533	NA	NA	0.566185883788484	0.575791049013412	NA	NA	p.Ile112Arg	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.161	-3.582	1.421	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112S	112	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile112Ser	1	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.161	-3.262	1.101	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112T	112	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile112Thr	1	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.161	-2.731	0.57	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112V	112	I	V	missense	wt-like	0.989973490726711	0.329527881021119	6	0.134529194087051	0.726301115446893	1.25364586600653	0.609861213508819	0.548228528369986	1.23549870650782	1.32885566859748	NA	NA	1.10725099100171	1.11014583637446	0.717415330103939	0.603180102144874	0.575861074366368	0.788200963543592	0.833254504556344	NA	NA	0.713498866304286	0.721331793903593	NA	NA	p.Ile112Val	1	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.161	-1.929	-0.232	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112W	112	I	W	missense	possibly_wt-like	0.742127842379628	0.180891769614805	6	0.0738487557042273	0.597386940896246	0.886868743863011	0.802341788305859	0.55915644500007	0.801549449767383	0.82424319254016	NA	NA	0.973626774151223	0.491849404513073	0.651267531602906	0.644178227797607	0.578223818558526	0.658356835408204	0.666124898362848	NA	NA	0.686011686833035	0.582276012967224	NA	NA	p.Ile112Trp	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.161	-5.783	3.622	0.008344822	NA	NA	NA	NA	NA	NA	NA
I112X	112	I	X	nonsense	low	0.178206743983416	0.145806314260028	6	0.0595251785354933	0.0615395378805323	0.294873950086299	0.379222742226302	0.0894793392658288	0.0853222697702026	0.037578852083267	NA	NA	0.133305381245438	0.344331879309458	0.494913706288959	0.554054391480485	0.476674100407451	0.444050917633059	0.405578622427942	NA	NA	0.513153312170467	0.549099103620951	NA	NA	p.Ile112Ter	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I112Y	112	I	Y	missense	possibly_wt-like	0.876090794153033	0.25585085486351	6	0.104450674111746	0.671371234733081	1.08081035357298	1.06619570620136	1.29624691879541	0.768774286369535	0.715467472309583	NA	NA	0.801673831876996	0.608186549365312	0.649595054420805	0.700378787730743	0.737591454221211	0.648550014795457	0.630097958586025	NA	NA	0.650640094046152	0.608440408709625	NA	NA	p.Ile112Tyr	0	6.5	21.9	8.6	0.889	28.9	-163.1	-91.2	98.6	3.66492146596859	-4.3	0	0	14.14	0	0	0	0	7	18.3873108224393	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.161	-3.608	1.447	0.008344822	NA	NA	NA	NA	NA	NA	NA
T113A	113	T	A	missense	possibly_wt-like	0.816273029266682	0.151033806096237	6	0.0616592931410394	0.695423035398048	0.937123023135317	1.06104454852627	0.928411904470611	0.668831632826013	0.701968327761389	NA	NA	0.735260527207048	0.802121234808765	0.644517573116351	0.699281597482619	0.658061194869128	0.618645673420683	0.625626989635919	NA	NA	0.636978540266688	0.652056605966015	NA	NA	p.Thr113Ala	1	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.265	-2.523	0.258	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113C	113	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr113Cys	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.265	-4.229	1.964	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113D	113	T	D	missense	wt-like	1.12864757030477	0.0261209620087366	6	0.0106638380853382	1.10774683172054	1.149548308889	1.15608220552678	1.10451215227989	1.15222460170823	1.10789432409204	NA	NA	1.10244491042096	1.14872722780075	0.724766653672682	0.71952450151362	0.696136141067347	0.763284102030391	0.760071251578301	NA	NA	0.712510231140765	0.730008805831745	NA	NA	p.Thr113Asp	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.265	-2.864	0.599	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113E	113	T	E	missense	wt-like	1.07594985123567	0.0730117741019646	6	0.0298069319608608	1.01752933810275	1.13437036436859	1.04331513795966	1.09526725222828	1.17513112056237	1.12808972570091	NA	NA	0.967341181980017	1.04655468898278	0.701267652876767	0.695505254841679	0.694137284867813	0.77013807613689	0.766760046798312	NA	NA	0.684718708627697	0.707030050911856	NA	NA	p.Thr113Glu	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.265	-2.948	0.683	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113F	113	T	F	missense	possibly_low	0.488871927702877	0.797994815516088	4	0.398997407758044	-0.293148621427732	1.27089247683349	1.09090661319319	1.20554815438553	0.116585596919111	NA	NA	NA	NA	-0.457552653686324	0.579523777340061	0.705642180522002	0.717981313871543	0.453405374158121	NA	NA	NA	NA	0.368754087524332	NA	NA	p.Thr113Phe	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.265	-3.947	1.682	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113G	113	T	G	missense	wt-like	0.993141385480732	0.0473784813848452	6	0.019342184030137	0.955231401399317	1.03105136956215	1.01905328466434	1.03850543767126	0.98838949564889	0.974507990411898	NA	NA	0.910129408083262	1.02826269640474	0.696626832346814	0.690337509935376	0.681864712499191	0.714262180287666	0.715893181321821	NA	NA	0.672949956420689	0.702916154758253	NA	NA	p.Thr113Gly	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.265	-2.711	0.446	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113H	113	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr113His	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.265	-4.145	1.88	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113I	113	T	I	missense	possibly_low	0.640078175762462	0.467434689364641	6	0.190829412836622	0.266059399411758	1.01409695211317	1.28383698538323	1.15121521340431	0.293217715745765	0.572921337934387	NA	NA	0.176052748740097	0.363225053366989	0.568117166622614	0.746736112466125	0.706233892556773	0.50625635411376	0.582886126867807	NA	NA	0.521946662582122	0.55334820637742	NA	NA	p.Thr113Ile	1	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.265	-2.923	0.658	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113K	113	T	K	missense	low	0.104447949673931	0.690426405290104	6	0.281865399650795	-0.447998082129616	0.656893981477478	1.02920151276237	0.923930702991817	-0.455815098050503	-0.334853371257478	NA	NA	-0.458378814107342	-0.0773972342952739	0.422846236841717	0.692499070036463	0.657092306367658	0.282134498524671	0.282227627805216	NA	NA	0.391440870733578	0.454251602949856	NA	NA	p.Thr113Lys	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.265	-3.257	0.992	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113L	113	T	L	missense	wt-like	0.893243505683889	0.0773856713977845	6	0.0315925680545438	0.831323210117853	0.955163801249926	0.896975727034031	1.02730491018473	0.823704102267899	0.893446636444604	NA	NA	0.90788888428226	0.810140773889815	0.668737454563477	0.66433514033323	0.67944302663136	0.664985839821485	0.689045346975913	NA	NA	0.672489069305469	0.653860212152627	NA	NA	p.Thr113Leu	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.265	-3.051	0.786	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113M	113	T	M	missense	wt-like	1.12224106189892	0.119799920395455	6	0.0489081126991514	1.02638292245676	1.21809920134108	0.930292833039014	1.15472527668669	1.21936515608372	1.25389326591255	NA	NA	1.13602699350467	1.03914284616687	0.713205522795459	0.671431642927417	0.706992809550313	0.783373563205865	0.808426666493482	NA	NA	0.719418236040605	0.705363116513025	NA	NA	p.Thr113Met	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.265	-3.782	1.517	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113N	113	T	N	missense	wt-like	0.888453534304792	0.116921377320331	6	0.0477329524097054	0.794898666706005	0.982008401903579	0.687464384639234	1.03542858444996	0.937394650995799	0.910078685518386	NA	NA	0.83922093953821	0.921133960687162	0.680011102226694	0.619709482132492	0.681199460619547	0.699003757694398	0.694553946037139	NA	NA	0.658363724621776	0.678822743833841	NA	NA	p.Thr113Asn	1	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.265	-3.019	0.754	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113P	113	T	P	missense	possibly_wt-like	1.01135035939396	0.363274275442269	6	0.148306101918805	0.72067574094558	1.30202497784235	1.28509742424165	1.26589946079909	1.0915608525056	0.446716814277485	NA	NA	1.30078264054601	0.678044963993953	0.738081287380048	0.747004584392446	0.731029976626279	0.745132598133818	0.541086699902748	NA	NA	0.753309308676	0.624151669361603	NA	NA	p.Thr113Pro	1	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.265	-2.461	0.196	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113Q	113	T	Q	missense	wt-like	0.946500219073544	0.149039128954288	6	0.0608449696078112	0.8272462700018	1.06575416814529	1.09116262621801	1.09792364400422	0.950268516522709	0.879615648696272	NA	NA	0.696632737147175	0.963398141852885	0.691519824324655	0.705696710981353	0.694711628034326	0.702855811406	0.68446447027285	NA	NA	0.629032607837826	0.688328020614984	NA	NA	p.Thr113Gln	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.265	-3.293	1.028	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113R	113	T	R	missense	wt-like	0.935692227929299	0.136420945848723	6	0.0556936179262043	0.826534742625205	1.04484971323339	0.947967459498538	1.01426256166087	0.981139671603432	1.08580262509908	NA	NA	0.895245905927459	0.689735143786411	0.675909716999391	0.67519631662094	0.676623117377842	0.712092924164523	0.752754395321225	NA	NA	0.669888344502132	0.626780808066857	NA	NA	p.Thr113Arg	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.265	-3.068	0.803	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113S	113	T	S	missense	wt-like	1.15094747342932	0.0603312581924401	6	0.0246301330185976	1.10267329977844	1.19922164708021	1.14197134193597	1.13842921863342	1.15219124603985	1.1279536622637	NA	NA	1.26339017768403	1.08174919401896	0.731068197123749	0.716518904927188	0.703469410001817	0.76327412151398	0.766714982060998	NA	NA	0.745617489320311	0.714945347087418	NA	NA	p.Thr113Ser	1	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.265	-2.458	0.193	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113T	113	T	T	synonymous	wt-like	1.03258382845802	0.22262002372894	6	0.0908842441103642	0.854453983239555	1.21071367367648	1.05426250429242	1.21871020682799	1.07836133380973	1.12802273399538	NA	NA	0.592956871511568	1.12318932031101	0.722546198615609	0.697837030403708	0.720827104521126	0.741183104108306	0.766737858886012	NA	NA	0.607705956181922	0.724265292710092	NA	NA	p.Thr113=	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113V	113	T	V	missense	wt-like	0.894010575591382	0.176217799311997	5	0.0788069956214081	0.739551702443616	1.04846944873915	1.08394904959443	0.988736624039742	NA	0.771139117910295	NA	NA	0.972762579058642	0.6534655073538	0.671104109235182	0.704160228034278	0.671104109235182	NA	0.648536623198697	NA	NA	0.685833917517204	0.618623713251945	NA	NA	p.Thr113Val	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.265	-2.616	0.351	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113W	113	T	W	missense	wt-like	1.01006845924595	0.135490402600242	6	0.0553137252358093	0.90165554993302	1.11848136855888	0.972613693086559	1.06617170797114	1.11460477467791	1.16771838498044	NA	NA	0.792119166527943	0.947183028231722	0.686263851682361	0.680445934056745	0.687846485757762	0.752027685374566	0.779885212214576	NA	NA	0.648674650899488	0.68468121760696	NA	NA	p.Thr113Trp	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.265	-4.624	2.359	0.008821424	NA	NA	NA	NA	NA	NA	NA
T113X	113	T	X	nonsense	low	-0.060120044129642	0.12000439690641	6	0.0489915898851888	-0.156141795849969	0.0359017075906848	-0.179508592168708	-0.235651029233687	0.0274386639450487	0.062590332071529	NA	NA	-0.0355896393920338	0	0.430888289460171	0.435045304574965	0.406377088097545	0.426731274345376	0.41386252145758	NA	NA	0.478410749381437	0.471658355281976	NA	NA	p.Thr113Ter	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T113Y	113	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr113Tyr	0	4.7	23.5	5.7	0.782	80	57.5	-62.5	-28	66.2576687116564	-1.5	0	0	15.25	0	0	0	0	5	21.6360796988627	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.265	-3.961	1.696	0.008821424	NA	NA	NA	NA	NA	NA	NA
E114A	114	E	A	missense	wt-like	1.23274190508757	0.0452660657529681	6	0.018479793959674	1.19652217448489	1.26896163569025	1.16449912784191	1.20049588494404	1.28583245031202	1.25676538157419	NA	NA	1.26539685834001	1.22346172751325	0.746423489468258	0.721317295612706	0.716888953755323	0.80326157484441	0.809377922322952	NA	NA	0.746030273713981	0.746816705222535	NA	NA	p.Glu114Ala	1	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.05	-3.023	0.973	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114C	114	E	C	missense	wt-like	1.02522900776898	0.10662196094173	6	0.0435282332803661	0.939915238228804	1.11054277730915	1.04755727637144	1.07330344547263	1.00854314071396	1.11127454333686	NA	NA	1.09059296182109	0.820102678897899	0.703240525138487	0.696408825104942	0.689388451342973	0.720292453255249	0.76119079328216	NA	NA	0.710072225172033	0.65610065930569	NA	NA	p.Glu114Cys	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.05	-5.611	3.561	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114D	114	E	D	missense	possibly_wt-like	0.774574704696994	0.536936480217756	3	0.310000421391452	0.166985043577509	1.38216436581648	1.18071401429683	0.977200662009116	NA	NA	NA	NA	NA	0.165809437785039	0.668609898471002	0.72477104648094	0.668609898471002	NA	NA	NA	NA	NA	0.508949142790496	NA	NA	p.Glu114Asp	1	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.05	-2.435	0.385	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114E	114	E	E	synonymous	possibly_low	0.0945344864497233	0.898796403613057	6	0.366932095250099	-0.624639205012291	0.813708177911738	1.26750402874017	1.22492970071745	-0.404955515135262	-0.337598913648301	NA	NA	-0.656364179797983	-0.52630820217773	0.352002569723215	0.743257212793061	0.722171832300713	0.297352448776649	0.2813182935332	NA	NA	0.350714276350546	0.353290863095885	NA	NA	p.Glu114=	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114F	114	E	F	missense	possibly_wt-like	0.77808593547392	0.312661009752483	6	0.127643322726157	0.52790962006363	1.02826225088421	0.981903963159721	1.13274552625571	0.795178439346132	0.722593575412668	NA	NA	0.215683592395328	0.820410516273967	0.656310212946279	0.682424750153949	0.702240528815215	0.656450533506221	0.632458151529764	NA	NA	0.530098928225462	0.656169892386337	NA	NA	p.Glu114Phe	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.05	-3.924	1.874	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114G	114	E	G	missense	wt-like	1.03542384926504	0.110698105285126	6	0.0451923122402414	0.946848544896078	1.123999153634	0.851927316431123	0.996787127195396	1.00246233487207	1.16162553388071	NA	NA	1.11970140827185	1.08003937493908	0.715310393282903	0.654739884290893	0.672844722768288	0.718472984917334	0.777867236335642	NA	NA	0.716059980315374	0.714560806250432	NA	NA	p.Glu114Gly	1	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.05	-2.641	0.591	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114H	114	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114His	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.05	-3.271	1.221	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114I	114	E	I	missense	low	0.46819379660162	0.130113982915448	5	0.0581887421244377	0.354145957732033	0.582241635471206	0.28417556839194	0.497706436561673	0.6315005414964	NA	NA	NA	0.407770602924306	0.51981583363378	0.569612201021021	0.533809460375582	0.564937603494786	0.607475650818396	NA	NA	NA	0.569612201021021	0.588565704191342	NA	NA	p.Glu114Ile	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.05	-3.774	1.724	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114K	114	E	K	missense	possibly_wt-like	0.910391090647273	0.34139139362163	8	0.12070008473429	0.673823271637132	1.14695890965741	0.963386697838596	1.05051150272246	0.89658616237	0.501966863093569	1.31472665676074	1.38062787916625	0.717034405978736	0.458288557247824	0.681470580244399	0.678480595419472	0.684460565069325	0.686793245649878	0.559385730027708	0.69821875171003	0.745274911237907	0.63322933464307	0.574728128837753	rs115106679	*32	p.Glu114Lys	1	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.05	-2.75	0.7	0.008602428	NA	NA	NA	NA	1.63e-05	NA	NA
E114L	114	E	L	missense	possibly_wt-like	0.80507666096756	0.130991200087453	6	0.0534769335015127	0.700263797300951	0.909889524634168	0.785361617487079	0.894340222394846	0.853835565334627	0.94516142335995	NA	NA	0.57087491592042	0.780886221308436	0.648987658127505	0.640561472301281	0.650694496195753	0.674001625631859	0.706173484668966	NA	NA	0.603163585863754	0.647280820059257	NA	NA	p.Glu114Leu	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.05	-3.402	1.352	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114M	114	E	M	missense	possibly_wt-like	0.729312450278008	0.263866570546652	6	0.107723076336233	0.518179100355132	0.940445800200884	0.979007146166406	0.631558604027467	0.241956176156852	0.83766231605022	NA	NA	0.867231335659152	0.818459123607949	0.65992831326663	0.681807731697878	0.593878017481566	0.490918132394484	0.670569364035241	NA	NA	0.664125605240307	0.655731021292953	NA	NA	p.Glu114Met	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.05	-4.101	2.051	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114N	114	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114Asn	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.05	-3.1	1.05	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114P	114	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114Pro	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.05	-3.582	1.532	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114Q	114	E	Q	missense	wt-like	0.957827381311984	0.125734282446663	6	0.0513308058615505	0.857220850525927	1.05843391209804	1.05631951136657	1.1467482257742	0.800907607930695	0.961606659813008	NA	NA	0.889944101004901	0.89143818198253	0.685209644856806	0.698275170380085	0.70526807725668	0.658164786701147	0.711620210666772	NA	NA	0.668797736325989	0.672144119333527	NA	NA	p.Glu114Gln	1	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.05	-2.479	0.429	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114R	114	E	R	missense	possibly_wt-like	0.721769206489923	0.0864707745194811	6	0.0353015458726643	0.652579447980912	0.790958964998934	0.811316906649877	0.835419532365521	0.611147718825023	0.670385530377957	NA	NA	0.720211753798528	0.682133796922632	0.629477092570248	0.646089916964185	0.637955149541011	0.601385780922756	0.615166644837424	NA	NA	0.633882931212791	0.625071253927706	NA	NA	p.Glu114Arg	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.05	-2.624	0.574	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114S	114	E	S	missense	wt-like	1.08768296096358	0.225631054390549	6	0.0921134922305003	0.907143833701587	1.26822208822557	0.72779826263552	0.94874172147085	1.07526831486355	1.17753942033914	NA	NA	1.36438488032519	1.23236516614721	0.744538364079793	0.628300548529178	0.662456740577514	0.740257626435203	0.783137977157564	NA	NA	0.766392612142916	0.748819101724382	NA	NA	p.Glu114Ser	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.05	-2.438	0.388	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114T	114	E	T	missense	wt-like	0.891376089274003	0.182473765407958	6	0.0744946027823027	0.745369350778073	1.03738282776993	1.00475110725983	1.08286533138081	0.576130337558402	0.914009421261669	NA	NA	0.793070601732324	0.977429736450982	0.689373503678725	0.68729116374197	0.69145584361548	0.590908055083791	0.695855820937178	NA	NA	0.648870365949009	0.691483746969003	NA	NA	p.Glu114Thr	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.05	-2.711	0.661	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114V	114	E	V	missense	possibly_low	0.68392552833254	0.123446588634288	6	0.0503968587735438	0.585149500202443	0.782701556462637	0.793385411077385	0.799580030516012	0.644821570889999	0.595012811405947	NA	NA	0.499934253544622	0.770819092561277	0.620833865046893	0.642270530465585	0.630206227426097	0.611461502667688	0.590202908431322	NA	NA	0.588570731630491	0.645016707931828	NA	NA	p.Glu114Val	1	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.05	-3.229	1.179	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114W	114	E	W	missense	possibly_low	0.691691041792384	0.153345160725984	6	0.0626028997172893	0.568991613018725	0.814390470566044	0.850920203342676	0.87184059414958	0.7547677640783	0.586154757628192	NA	NA	0.560096116641198	0.52636681491436	0.622652692671332	0.654525370441949	0.645829811758476	0.644359053186777	0.587269086717115	NA	NA	0.600946332155887	0.590039029559124	NA	NA	p.Glu114Trp	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.05	-5.883	3.833	0.008602428	NA	NA	NA	NA	NA	NA	NA
E114X	114	E	X	nonsense	low	-0.258293596916037	0.169684818401814	6	0.0692735370302116	-0.394067234576954	-0.122519959255121	-0.151050839368702	-0.0188608867359483	-0.233935689279055	-0.246839667214473	NA	NA	-0.47466578692506	-0.424408711972986	0.382149383378676	0.441106770914201	0.453249668429433	0.348524146474584	0.311378107419333	NA	NA	0.388090557778068	0.376208208979283	NA	NA	p.Glu114Ter	1	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E114Y	114	E	Y	missense	wt-like	0.821353320285556	0.0899935252296405	6	0.0367397028278173	0.74934482594033	0.893361814630783	0.736752428414175	0.941140944977578	0.923849602779159	0.789058404826846	NA	NA	0.799367670645223	0.737950870070357	0.652318632698329	0.630207774825108	0.660813363241899	0.694950876052309	0.654471560418306	NA	NA	0.650165704978351	0.63762459613732	NA	NA	p.Glu114Tyr	0	7.6	23.4	3.3	0.704	108.9	46.4	-73.8	-20.2	33.6448598130841	-0.6	0	0	13.27	0	0	0	0	4	20.7515856833135	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.05	-3.892	1.842	0.008602428	NA	NA	NA	NA	NA	NA	NA
I115A	115	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Ala	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.249	-2.936	0.687	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115C	115	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Cys	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.249	-5.503	3.254	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115D	115	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Asp	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.249	-3.331	1.082	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115E	115	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Glu	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.249	-3.091	0.842	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115F	115	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Phe	1	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.249	-3.102	0.853	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115G	115	I	G	missense	wt-like	0.885315972092115	0.101612081540559	6	0.041482958579408	0.804010867304308	0.966621076879921	0.79910907544194	0.866645229314082	1.0301707225354	0.75837205024729	NA	NA	0.89029237297009	0.967306382043892	0.656787945185203	0.643489663934298	0.644706512733901	0.726763750213732	0.64430812094795	NA	NA	0.668869377636506	0.689206989607594	NA	NA	p.Ile115Gly	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.249	-3.044	0.795	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115H	115	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115His	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.249	-3.006	0.757	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115K	115	I	K	missense	wt-like	1.13715983417645	0.174301401249988	6	0.0711582490857633	0.997692228765428	1.27662743958748	0.958056378812735	0.959738071296955	1.1523776362708	1.06966254634236	NA	NA	1.34120556507184	1.34191880726403	0.754516624053974	0.67734524402403	0.664834280832081	0.763329892267482	0.747408738734177	NA	NA	0.761624509373771	0.773457877455403	NA	NA	p.Ile115Lys	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.249	-3.163	0.914	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115L	115	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Leu	1	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.249	-2.457	0.208	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115M	115	I	M	missense	wt-like	1.00854238286406	0.355166525157032	6	0.144996126725349	0.724355196584568	1.29272956914355	1.21036730138485	1.56408686012043	0.708485758500268	0.597645658674599	NA	NA	0.881879010138454	1.08878970836573	0.691833737687047	0.731087160152844	0.795501601893061	0.630510782751252	0.591074917642461	NA	NA	0.66713870620912	0.716528769164974	NA	NA	p.Ile115Met	1	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.249	-3.359	1.11	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115N	115	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Asn	1	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.249	-3.374	1.125	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115P	115	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Pro	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.249	-4.045	1.796	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115Q	115	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Gln	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.249	-2.919	0.67	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115R	115	I	R	missense	possibly_low	0.628175838316868	0.344552979780836	6	0.140663164969756	0.352481101024729	0.903870575609006	1.01877968046479	1.08203545963144	0.364658081146188	0.354871049824224	NA	NA	0.326765950410145	0.621944808424415	0.582241897222266	0.690279232577446	0.691276415576044	0.527632383257739	0.510667027041012	NA	NA	0.552949132947406	0.611534661497125	NA	NA	p.Ile115Arg	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.249	-2.967	0.718	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115S	115	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Ser	1	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.249	-2.726	0.477	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115T	115	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Thr	1	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.249	-2.859	0.61	0.008752217	NA	NA	NA	NA	4.07e-06	NA	NA
I115V	115	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Val	1	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.249	-2.393	0.144	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115W	115	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Trp	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.249	-3.696	1.447	0.008752217	NA	NA	NA	NA	NA	NA	NA
I115X	115	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Ter	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I115Y	115	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile115Tyr	0	7.9	19.6	3.6	0.839	91.4	-138.2	-128.2	84.8	8.37696335078534	-3.6	0	0	14.12	0	0	0	0	5	18.2883728390246	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.249	-3.582	1.333	0.008752217	NA	NA	NA	NA	NA	NA	NA
P116A	116	P	A	missense	possibly_wt-like	0.760306779069271	0.139185602429321	6	0.0568222842489534	0.648937148422025	0.871676409716517	0.845674131504039	0.92469475804106	0.723347766309669	0.864610344869013	NA	NA	0.605680884829458	0.597832788862385	0.644182841027761	0.653407963593749	0.657257504061894	0.634957718461773	0.679494655536881	NA	NA	0.610323350288371	0.606111832676883	NA	NA	p.Pro116Ala	1	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.169	-2.548	0.379	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116C	116	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro116Cys	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.169	-3.79	1.621	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116D	116	P	D	missense	wt-like	1.03327599982227	0.075713902686089	5	0.0338602866495798	0.966911057482887	1.09964094216164	1.12639502367641	0.978319296578457	1.03430438065852	NA	NA	NA	0.941327434596174	1.08603386360177	0.713201168299032	0.713201168299032	0.668851760430726	0.728000602741235	NA	NA	NA	0.679367548786217	0.715908975606342	NA	NA	p.Pro116Asp	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.169	-2.793	0.624	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116E	116	P	E	missense	possibly_wt-like	0.828222686959788	0.250832891844073	6	0.10240209928745	0.627518260415092	1.02892711350448	1.07336204662366	1.21377368111996	0.688619599314445	0.690130402672226	NA	NA	0.701633079759949	0.601817312268485	0.627313866779489	0.701905209425053	0.719759769562332	0.624566529871877	0.621706223003753	NA	NA	0.630061203687101	0.60700795787726	NA	NA	p.Pro116Glu	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.169	-2.706	0.537	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116F	116	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro116Phe	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.169	-4.768	2.599	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116G	116	P	G	missense	possibly_wt-like	0.772347937243413	0.120739151455826	6	0.0492915521738984	0.675738270240495	0.868957604246331	0.82308014863404	0.939284127446438	0.761316850313056	0.839222381371908	NA	NA	0.620591268797761	0.650592846897273	0.64745705554007	0.648595473036317	0.660411897437747	0.646318638043824	0.671086063711173	NA	NA	0.613390491932169	0.617977647671484	NA	NA	p.Pro116Gly	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.169	-2.348	0.179	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116H	116	P	H	missense	wt-like	0.958645808014286	0.151842513096416	6	0.0619894463913485	0.837148725665667	1.08014289036291	0.835794849276497	0.787316888542997	1.10378810812653	0.867325096889134	NA	NA	1.15801767339571	0.999632231854852	0.688435456452008	0.651303688632233	0.627554791799786	0.748791176460496	0.680393791918884	NA	NA	0.723941830484089	0.696477120985131	NA	NA	p.Pro116His	1	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.169	-3.016	0.847	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116I	116	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro116Ile	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.169	-3.754	1.585	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116K	116	P	K	missense	possibly_wt-like	0.754578869044852	0.197460535207822	6	0.0806129259326726	0.596580437528419	0.912577300561285	0.676442310419239	0.797772005461688	1.00720541774132	0.948999320591534	NA	NA	0.533557420793929	0.563496739261402	0.623588552506041	0.617361793882383	0.629815311129699	0.719892186472044	0.707444611094412	NA	NA	0.595487187751672	0.598389604396896	NA	NA	p.Pro116Lys	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.169	-3.012	0.843	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116L	116	P	L	missense	wt-like	0.968664083937504	0.18938231392688	6	0.0773150059047393	0.817129456899713	1.12019871097529	0.984862022827944	0.978108470546168	0.849463174846067	0.673660696263852	NA	NA	1.12939900978269	1.1964911293583	0.677874077011683	0.683054813224437	0.668806177361217	0.672693340798929	0.616251392461987	NA	NA	0.718054826155835	0.740750977853761	NA	NA	p.Pro116Leu	1	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.169	-3.007	0.838	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116M	116	P	M	missense	wt-like	0.887354899705544	0.0361597052504772	6	0.0147621378521845	0.858421641180447	0.916288158230641	0.863913657989382	0.847325485727948	0.922369238765331	0.93606170780034	NA	NA	0.894293904993594	0.860165402956669	0.667401669105224	0.657292960297863	0.640529356785761	0.694507928929546	0.703159623636768	NA	NA	0.669692513079186	0.665110825131262	NA	NA	p.Pro116Met	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.169	-5.183	3.014	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116N	116	P	N	missense	possibly_wt-like	0.796878747344353	0.316516488512727	6	0.129217315338946	0.543617463101065	1.05014003158764	1.07383528796429	1.0331689790673	0.811375188113675	0.23042423459682	NA	NA	0.968788148894872	0.663680645429166	0.671003875538866	0.702006009248452	0.680710907341263	0.661296843736468	0.469449759914568	NA	NA	0.685016357064597	0.620921112895942	NA	NA	p.Pro116Asn	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.169	-3.138	0.969	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116P	116	P	P	synonymous	possibly_wt-like	0.72165595733669	0.43253518065836	5	0.193435613322449	0.342529121897273	1.10078279277611	0.815909024888585	0.950071018015716	0.735346489548107	1.11496288894264	NA	NA	-0.00800963471159755	NA	0.647068032500058	0.647068032500058	0.662744150135745	0.638547916470949	0.762412387629997	NA	NA	0.48408409629667	NA	NA	NA	p.Pro116=	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116Q	116	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro116Gln	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.169	-3.026	0.857	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116R	116	P	R	missense	wt-like	0.865219307030799	0.0732216462249121	6	0.0298926118962701	0.806630864310276	0.923807749751322	0.969654740319543	0.938604112907587	0.85386219047566	0.83734906048938	NA	NA	0.797540047463308	0.794305690529318	0.66536524143569	0.679815680757312	0.660264870290978	0.674009592273512	0.670465612580402	NA	NA	0.649789753615707	0.650298878511646	NA	NA	p.Pro116Arg	1	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.169	-3.127	0.958	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116S	116	P	S	missense	wt-like	1.08321586732103	0.217472629864483	6	0.0887828293648558	0.90920471932035	1.25722701532171	0.923700570404548	0.773800099463317	1.24542191365203	1.0148329730674	NA	NA	1.35428174370131	1.18725790363759	0.733961691742822	0.670027499095715	0.624632302914144	0.791170135998512	0.729248971736738	NA	NA	0.764314345671846	0.738674411748907	NA	NA	p.Pro116Ser	1	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.169	-2.452	0.283	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116T	116	P	T	missense	possibly_wt-like	0.792612259197976	0.507366378838328	5	0.226901142516082	0.347894191815464	1.23733032658049	1.22980837882414	1.10443345073367	1.11460410711753	NA	NA	NA	0.078081693484352	0.436133665830189	0.696119124866772	0.735228085732066	0.696119124866772	0.752027485630486	NA	NA	NA	0.501793519369947	0.569745461028455	NA	NA	p.Pro116Thr	1	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.169	-2.893	0.724	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116V	116	P	V	missense	wt-like	0.995889182883094	0.0835560262938831	6	0.0341116048924314	0.929031665839069	1.06274669992712	1.05766676755418	1.10043522167483	0.873126154027486	1.02294929678327	NA	NA	0.930041554666689	0.991116102592107	0.694908245809955	0.698562134290725	0.695254660686868	0.679773659184484	0.731937129582084	NA	NA	0.677045986015452	0.694561830933042	NA	NA	p.Pro116Val	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.169	-3.037	0.868	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116W	116	P	W	missense	possibly_low	0.666581886116155	0.178403955490226	6	0.0728331098408759	0.523831613945988	0.809332158286321	0.737379742138886	0.938328520965533	0.687622485458264	0.699804190549421	NA	NA	0.466333717672858	0.470022659911966	0.624589198728552	0.630341391876785	0.660205284069511	0.624268178446459	0.624910219010644	NA	NA	0.581658930898511	0.577367145861735	NA	NA	p.Pro116Trp	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.169	-5.915	3.746	0.009029629	NA	NA	NA	NA	NA	NA	NA
P116X	116	P	X	nonsense	low	0.122348425357815	0.158653658063886	6	0.0647700846804198	-0.00459860789141683	0.249295458607048	0.162197831122326	0.313071355590623	0.17303190271774	0.0143182423141979	NA	NA	0.206979310821467	-0.13550809041946	0.4890616540508	0.507828352387471	0.525017325915788	0.470294955714129	0.397874618395185	NA	NA	0.528308413336557	0.441182385560225	NA	NA	p.Pro116Ter	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P116Y	116	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro116Tyr	0	4.4	18.1	3.2	0.109	83.9	25.6	-51.7	138.7	77.9220779220779	-0.2	0	0	15.42	0	0	0	0	4	20.3799455617323	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.169	-3.742	1.573	0.009029629	NA	NA	NA	NA	NA	NA	NA
G117A	117	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Ala	1	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.816	-2.312	0.496	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117C	117	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Cys	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.816	-4.418	2.602	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117D	117	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Asp	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.816	-2.571	0.755	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117E	117	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Glu	1	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.816	-2.697	0.881	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117F	117	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Phe	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.816	-3.869	2.053	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117H	117	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117His	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.816	-3.061	1.245	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117I	117	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Ile	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.816	-4.456	2.64	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117K	117	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Lys	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.816	-2.942	1.126	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117L	117	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Leu	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.816	-3.395	1.579	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117M	117	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Met	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.816	-5.218	3.402	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117N	117	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Asn	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.816	-2.679	0.863	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117P	117	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Pro	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.816	-3.043	1.227	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117Q	117	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Gln	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.816	-2.952	1.136	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117R	117	G	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Arg	1	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.816	-3.049	1.233	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117S	117	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Ser	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.816	-2.61	0.794	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117T	117	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Thr	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.816	-3.258	1.442	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117V	117	G	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Val	1	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.816	-3.437	1.621	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117W	117	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Trp	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.816	-5.84	4.024	0.008036586	NA	NA	NA	NA	NA	NA	NA
G117X	117	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Ter	1	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G117Y	117	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly117Tyr	0	3.7	15.2	5.6	0.388	100.9	102.8	93.1	-3.3	92.7835051546392	-0.6	0	0	16.15	0	0	0	0	3	18.8922109781949	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.816	-3.669	1.853	0.008036586	NA	NA	NA	NA	NA	NA	NA
T118A	118	T	A	missense	wt-like	0.924435043139348	0.134135773696231	6	0.054760700301534	0.81710604278015	1.03176404349855	1.01768914777219	1.11411259902128	0.98301780469588	0.853767791151892	NA	NA	0.779439873511869	0.798583042682985	0.682975255106584	0.690046950455434	0.698211870645838	0.712654889763319	0.675903559757734	NA	NA	0.646066455986051	0.651260861329948	NA	NA	p.Thr118Ala	1	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.834	-2.253	-0.581	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118C	118	T	C	missense	possibly_low	0.660509361787063	0.194939107496071	6	0.0795835573798224	0.504528455561035	0.816490268013092	0.333806659911127	0.621140751748654	0.632497846438814	0.924482336093094	NA	NA	0.688207413307955	0.762921163222735	0.617536767695083	0.544380821815724	0.591625555205384	0.607774059419682	0.699324490885947	NA	NA	0.627299475970485	0.643240451955961	NA	NA	p.Thr118Cys	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.834	-3.816	0.982	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118D	118	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr118Asp	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.834	-2.957	0.123	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118E	118	T	E	missense	wt-like	0.968802399730873	0.0750607966336517	6	0.030643441906544	0.908742357231701	1.02886244223004	0.999144576214071	0.998053771032152	0.951506614062807	1.05291344299361	NA	NA	0.979864142492433	0.83133185159017	0.686695862338952	0.686096979526069	0.673118586073631	0.703226268765112	0.741861370843784	NA	NA	0.687294745151835	0.658626116833065	NA	NA	p.Thr118Glu	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.834	-2.698	-0.136	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118F	118	T	F	missense	possibly_wt-like	0.820108808277406	0.239382640013823	6	0.0977275535523695	0.628566323017553	1.01165129353726	1.16764752697506	1.05322954543881	0.730506724350231	0.694206566342552	NA	NA	0.739616404201919	0.535446082355861	0.637487176190533	0.72198790075508	0.685048237894758	0.637099786112993	0.623056264196402	NA	NA	0.637874566268072	0.59208097021954	NA	NA	p.Thr118Phe	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.834	-2.488	-0.346	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118G	118	T	G	missense	wt-like	1.08034362084423	0.0617409409132823	6	0.0252056335794779	1.03094148682094	1.12974575486752	1.00986688193646	1.06947692129791	1.08356400953294	1.10396751782926	NA	NA	1.18479787584661	1.03038851862218	0.716422454668806	0.688380817454947	0.688561111779905	0.74273982274017	0.75877067813742	NA	NA	0.729450654022176	0.703394255315436	NA	NA	p.Thr118Gly	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.834	-2.393	-0.441	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118H	118	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr118His	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.834	-3.329	0.495	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118I	118	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr118Ile	1	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.834	-3.458	0.624	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118K	118	T	K	missense	possibly_wt-like	0.933075955779275	0.316597313526722	6	0.129250312012736	0.679749999243748	1.1864019123148	0.519086679749541	0.730085819932513	1.0706762729988	1.03604403709128	NA	NA	1.42803729384808	0.814525631055438	0.695560265644356	0.583845238119997	0.615180761181892	0.738883618615097	0.736274158281776	NA	NA	0.779486236603515	0.654846373006935	NA	NA	p.Thr118Lys	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.834	-3.376	0.542	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118L	118	T	L	missense	possibly_wt-like	0.737884646157918	0.160109006625099	6	0.0653642282425641	0.609773112925237	0.865996179390599	0.912419039525364	0.596266228020771	0.496002670564729	0.777370349178678	NA	NA	0.782446176540932	0.862803413117034	0.648642649449869	0.667624546896369	0.586247390413298	0.566932654967967	0.650600431125371	NA	NA	0.646684867774367	0.665704117513467	NA	NA	p.Thr118Leu	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.834	-2.649	-0.185	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118M	118	T	M	missense	possibly_wt-like	0.858359843928729	0.429630975121169	6	0.17539611112354	0.514589783098206	1.20212990475925	0.704109771643162	0.657243475154497	0.67095040941726	0.365790049010571	NA	NA	1.52595827341701	1.22610708492988	0.621267286126384	0.623254929088087	0.599431388918777	0.619279643164681	0.514283441855603	NA	NA	0.799629078992807	0.747411650013526	NA	NA	p.Thr118Met	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.834	-3.919	1.085	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118N	118	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr118Asn	1	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.834	-3.132	0.298	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118P	118	T	P	missense	possibly_wt-like	0.912430887840488	0.316812670230137	6	0.129338231018745	0.658932613219627	1.16592916246135	0.935796987541264	1.30443297716724	0.431109637684055	0.669665250975699	NA	NA	0.998303705679732	1.13527676799494	0.681845938967499	0.672604021065488	0.739361376387479	0.547515685943195	0.614928085510097	NA	NA	0.69108785686951	0.726983777551023	NA	NA	p.Thr118Pro	1	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.834	-3.241	0.407	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118Q	118	T	Q	missense	possibly_low	0.425590121980391	0.488988374712358	6	0.199628668033023	0.0343251223539635	0.816855121606818	1.0845845117665	1.00998566032136	-0.0230701632983406	0.157768748902107	NA	NA	0.0992237459303926	0.225048228260326	0.514207290561847	0.704295580695219	0.675698400971005	0.411618275452785	0.445385981692455	NA	NA	0.506142546841705	0.522272034281989	NA	NA	p.Thr118Gln	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.834	-3.076	0.242	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118R	118	T	R	missense	wt-like	1.07707017853134	0.116297266182229	6	0.047478160104516	0.984014694674259	1.17012566238841	0.924189561995611	0.968788270169502	1.13685597477249	1.04338287336035	NA	NA	1.18482748176632	1.20437690912375	0.734080776691997	0.670131653703081	0.666791040345154	0.75868557827649	0.738704809273901	NA	NA	0.729456744110093	0.74252450137269	NA	NA	p.Thr118Arg	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.834	-3.381	0.547	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118S	118	T	S	missense	wt-like	1.1269360396267	0.205075377576636	6	0.0837216723118927	0.962844577169927	1.29102750208348	0.856810629312528	1.03427522022054	1.32371571988882	1.12440800661455	NA	NA	1.40587639195583	1.01653026976794	0.732909080927331	0.655780023927449	0.680950089698562	0.814596817462557	0.765540647179368	NA	NA	0.774927626630604	0.700277514675294	NA	NA	p.Thr118Ser	1	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.834	-3.008	0.174	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118V	118	T	V	missense	wt-like	1.10525969003918	0.103521288883807	6	0.0422623892134297	1.02242692928025	1.18809245079812	1.02351000377402	0.991687424442313	1.27092543848138	1.16298713026057	NA	NA	1.05360744755839	1.12884069571844	0.714000206298128	0.691286785623327	0.671742107011831	0.79880117325554	0.778318202329464	NA	NA	0.702464117208243	0.725536295388013	NA	NA	p.Thr118Val	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.834	-3.207	0.373	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118W	118	T	W	missense	low	0.56173737181885	0.164112751011892	6	0.0669987500439265	0.430422234723553	0.693052508914147	0.75926243680391	0.522349429174567	0.391790757787321	0.435523442910265	NA	NA	0.771746199309016	0.489751964928021	0.576035002120393	0.635002378921545	0.570265708534792	0.535750887178935	0.537379411959339	NA	NA	0.644483828161607	0.581804295705994	NA	NA	p.Thr118Trp	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.834	-4.552	1.718	0.008556007	NA	NA	NA	NA	NA	NA	NA
T118X	118	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr118Ter	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T118Y	118	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr118Tyr	0	6.1	16.3	8.3	0.729	50.2	-157.7	-114.4	162.2	17.7914110429448	-4.3	0	0	15.58	1	3	0	0	5	16.0526400889837	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.834	-3.27	0.436	0.008556007	NA	NA	NA	NA	NA	NA	NA
K119A	119	K	A	missense	possibly_low	0.710521824243498	0.266885292811879	6	0.108955464540397	0.496973037825488	0.924070610661507	1.06465521973749	0.933850630008487	0.477199294010793	0.832702514546504	NA	NA	0.440228663523071	0.514494623634644	0.623303033771653	0.700050666008959	0.659237111341806	0.561306402596927	0.668926658570266	NA	NA	0.576288988791948	0.5873689562015	NA	NA	p.Lys119Ala	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.076	-2.925	0.849	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119C	119	K	C	missense	possibly_wt-like	0.786475396422947	0.156566322143409	6	0.0639179333592614	0.661198549072563	0.91175224377333	0.800275764099945	0.967205702954479	0.718919143857914	0.963717256800091	NA	NA	0.695436375460134	0.573298135365117	0.638685387682533	0.643738167183256	0.666448870687152	0.63363260818181	0.712319248562229	NA	NA	0.628786510167962	0.600593952860247	NA	NA	p.Lys119Cys	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.076	-4.54	2.464	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119D	119	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys119Asp	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.076	-2.949	0.873	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119E	119	K	E	missense	low	0.298549822231626	0.205239302406585	6	0.0837885943434842	0.13432719500316	0.462772449460091	0.620141810961322	0.486541489500126	0.204224028564963	0.139779606264697	NA	NA	0.219577130994607	0.12103486710404	0.514889562285769	0.605369856755631	0.562523610533601	0.479628107741497	0.439427907987581	NA	NA	0.530899848872775	0.498879275698762	NA	NA	p.Lys119Glu	1	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.076	-2.5	0.424	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119F	119	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys119Phe	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.076	-3.34	1.264	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119G	119	K	G	missense	low	0.434054007153091	0.112926199243519	6	0.0461019277897483	0.343695889067318	0.524412125238864	0.582173257109196	0.471761125189091	0.472996817872464	0.438755195240762	NA	NA	0.240155937486762	0.398481710020269	0.559688440249011	0.597282601491959	0.55932792181122	0.560048958686803	0.538449780846234	NA	NA	0.535133013793674	0.561277480543483	NA	NA	p.Lys119Gly	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.076	-2.567	0.491	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119H	119	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys119His	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.076	-3.065	0.989	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119I	119	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys119Ile	1	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.076	-3.66	1.584	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119L	119	K	L	missense	low	0.431764883050401	0.306466413788092	6	0.12511438951358	0.186545185656069	0.676984580444732	0.798239724678528	0.84903272409352	0.282629332010002	0.16490031547608	NA	NA	0.255530565908056	0.240256636136221	0.531994040278958	0.643304493291119	0.640898481813836	0.503088150843036	0.447747984158909	NA	NA	0.538295652877222	0.525692427680694	NA	NA	p.Lys119Leu	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.076	-3.093	1.017	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119M	119	K	M	missense	possibly_low	0.678709577253857	0.260274923169834	6	0.106256792434698	0.470450090969101	0.886969063538613	0.666759034682268	0.921678226130555	0.687693529176965	0.872476666494884	NA	NA	0.733702149889977	0.189947857148492	0.630473704968834	0.615299268062243	0.656605294359599	0.62428943579296	0.682100011721879	NA	NA	0.636657974144708	0.514377908965079	NA	NA	p.Lys119Met	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.076	-3.951	1.875	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119N	119	K	N	missense	possibly_low	0.575231396085496	0.40638736215752	6	0.165906945866926	0.250059757401284	0.900403034769708	0.0233267932660786	1.05404423777739	0.74691842952254	0.93987587465059	NA	NA	0.448862283188915	0.238360758107466	0.610037691346166	0.478248992155618	0.685224383966925	0.642010414524527	0.704422890468018	NA	NA	0.578064968167806	0.525266041911242	NA	NA	p.Lys119Asn	1	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.076	-3.111	1.035	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119P	119	K	P	missense	low	0.100445945569693	0.575276383099836	6	0.234855599944743	-0.359862571889549	0.560754463028936	1.03829386069916	0.603651797412865	-0.272583148534532	-0.238415691892639	NA	NA	-0.296712120654222	-0.231559023612475	0.422138459365043	0.694435728962093	0.587844237440746	0.336960246839478	0.314168160667961	NA	NA	0.424696529941234	0.419580388788851	NA	NA	p.Lys119Pro	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.076	-3.241	1.165	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119Q	119	K	Q	missense	possibly_wt-like	0.755889949779187	0.280330678894697	6	0.114444520423334	0.531582811521493	0.98019708803688	0.896110348776914	0.859921795585512	1.06616611080994	0.897093407540867	NA	NA	0.36213863462581	0.453909401336072	0.653701821529477	0.664150815829006	0.643252827229949	0.737534110422459	0.6902531716852	NA	NA	0.560225473586348	0.573743250203863	NA	NA	p.Lys119Gln	1	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.076	-2.871	0.795	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119R	119	K	R	missense	possibly_wt-like	0.817400327041722	0.201394559660363	6	0.0822189846900656	0.656254078203743	0.9785465758797	0.984563667162267	1.0407632394757	0.838673383748796	0.67952091897148	NA	NA	0.496069906838101	0.864810846053983	0.667810232785255	0.682991263834669	0.682352875822638	0.669464873423938	0.618192320916599	NA	NA	0.58777581590365	0.666155592146572	NA	NA	p.Lys119Arg	1	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.076	-2.68	0.604	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119S	119	K	S	missense	wt-like	0.917057694059689	0.0881402198901039	6	0.0359830940912439	0.846532125588535	0.987583262530843	1.00875715096376	0.969682306371787	0.97654240962163	0.806145754364374	NA	NA	0.809328973182497	0.931889569854084	0.674113018859633	0.688144446122892	0.666984341494498	0.71071735440708	0.660130956756286	NA	NA	0.652214795458079	0.681241696224768	NA	NA	p.Lys119Ser	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.076	-2.81	0.734	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119T	119	K	T	missense	wt-like	0.934717561412401	0.122703330974838	6	0.0500934251046991	0.836536252344937	1.03289887047987	0.999423501335736	1.10233299149181	0.78965977274468	0.879234194144327	NA	NA	1.01467522169745	0.822979687060404	0.68524726064096	0.686156390233866	0.695664980857209	0.654799265662792	0.684338131048055	NA	NA	0.694455560790267	0.656747702691649	rs151149760	*9	p.Lys119Thr	1	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.076	-2.713	0.637	0.008846906	1.041533546	0.0317979731075584	1.035	0.745	0.0003358	NA	NA
K119V	119	K	V	missense	possibly_low	0.58345106663112	0.23241912268596	6	0.0948847095076542	0.397480453312573	0.769421679949668	0.425755798874553	1.04056005997754	0.583341824801214	0.547955324172119	NA	NA	0.462018754509726	0.441074637451565	0.577694303754108	0.563965875304151	0.682308946023803	0.593065840260417	0.574617286428287	NA	NA	0.580771321079929	0.570856692845411	NA	NA	p.Lys119Val	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.076	-3.381	1.305	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119W	119	K	W	missense	possibly_low	0.609259727604168	0.144854932747813	6	0.0591367786595523	0.493353771269729	0.725165683938607	0.709433159918083	0.723811540709071	0.705425567445341	0.665096689460335	NA	NA	0.458664270899056	0.393127137193122	0.613619574206325	0.624388804242105	0.613824188168299	0.629595127675727	0.61341496024435	NA	NA	0.580081286779163	0.560073229204334	NA	NA	p.Lys119Trp	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.076	-5.848	3.772	0.008846906	NA	NA	NA	NA	NA	NA	NA
K119X	119	K	X	nonsense	possibly_low	0.628203307170845	0.417355807968753	6	0.170384795118408	0.294255245225531	0.96215136911616	0.0167025443155551	0.280161283963525	0.731390022155507	1.183184409067	NA	NA	0.702085968672487	0.855695614850996	0.63375922365148	0.476838035277944	0.517901781093055	0.637364082068403	0.785007619284578	NA	NA	0.630154365234557	0.664105563183068	NA	NA	p.Lys119Ter	1	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K119Y	119	K	Y	missense	possibly_wt-like	0.781637642570355	0.121243235081861	6	0.0494973434524782	0.684624632073088	0.878650653067621	0.871146203663276	0.989392562219164	0.703368523393332	0.699415499737415	NA	NA	0.706699227458537	0.719803838950403	0.632323319003121	0.658833483629321	0.671245930789675	0.628979629233639	0.624781483108494	NA	NA	0.631103335976451	0.633543302029791	NA	NA	p.Lys119Tyr	0	5.7	18	11.7	0.944	14.5	-135.9	-138.2	151	28.2608695652174	-4	0	1	15.5	2	26	2	26	7	16.2505031868692	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.076	-3.465	1.389	0.008846906	NA	NA	NA	NA	NA	NA	NA
V120A	120	V	A	missense	wt-like	0.93727150965515	0.0899048850910607	6	0.0367035156427756	0.865333940889307	1.00920907842099	0.956062981129977	0.765813579797568	0.954811975431872	0.995944922878308	NA	NA	1.02016750327934	0.930828095413831	0.688294160018415	0.676920652769771	0.622905523364613	0.704215282476905	0.722993176369705	NA	NA	0.695585350981794	0.681002969055036	NA	NA	p.Val120Ala	1	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.064	-2.878	0.814	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120C	120	V	C	missense	possibly_wt-like	0.822779075611579	0.238999341242137	6	0.097571072484092	0.631543287609812	1.01401486361335	0.861265294727839	1.19241941218317	0.614575236656837	0.521003903901145	NA	NA	0.936491463913934	0.810919142286549	0.655382065267982	0.656728862181025	0.715142725287918	0.60241134568091	0.565690871664551	NA	NA	0.678372765077144	0.654035268354938	NA	NA	p.Val120Cys	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.064	-3.041	0.977	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120D	120	V	D	missense	low	0.140888427560114	0.300123731284202	6	0.122525000224411	-0.0992561600854943	0.381033015205722	0.257384773195411	0.248342583976019	-0.068204809712426	0.0666778749551522	NA	NA	-0.262023001491877	0.603153144438403	0.471427230721888	0.528103053955287	0.511022203663762	0.398113312092884	0.415216331489739	NA	NA	0.431832257780013	0.607308388505702	NA	NA	p.Val120Asp	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.064	-3.713	1.649	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120E	120	V	E	missense	low	0.46503141417578	0.243901941187177	6	0.0995725505304825	0.269872801287239	0.66019002706432	0.714762813875014	0.657723975353084	0.601119298646946	0.434271977800444	NA	NA	0.0718610701602906	0.310449349218899	0.569931999849221	0.625524013978684	0.599535278716986	0.598385127149597	0.536964921868639	NA	NA	0.500513905586146	0.541478872548845	NA	NA	p.Val120Glu	1	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.064	-3.257	1.193	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120F	120	V	F	missense	possibly_wt-like	0.939440418347044	0.490316117740375	6	0.200170716854386	0.547113022552882	1.33176781414121	0.946016041563065	0.923278406317926	1.46819241723009	1.49031470164412	NA	NA	0.252415228156756	0.5564257151703	0.665865969575366	0.674780667001212	0.65695127214952	0.857826412883615	0.886730361555175	NA	NA	0.537654812093255	0.596799320632767	NA	NA	p.Val120Phe	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.064	-2.665	0.601	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120G	120	V	G	missense	low	0.447666901297149	0.0752985409603339	6	0.0307405006214795	0.387416627212318	0.50791717538198	0.556780494229542	0.440734675604922	0.383249863204429	0.503225720682587	NA	NA	0.351992179794872	0.450018474266539	0.558970482438209	0.591873974235376	0.552619638243564	0.533195323381126	0.559802668536145	NA	NA	0.558138296340272	0.572868174957849	NA	NA	p.Val120Gly	1	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.064	-3.068	1.004	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120H	120	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val120His	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.064	-3.022	0.958	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120I	120	V	I	missense	possibly_wt-like	0.754427938175024	0.392907679386987	6	0.160403888419861	0.440042093891915	1.06881378245813	0.926692423147085	0.894170581816951	1.06438884820855	1.06875993987363	NA	NA	0.0747715261897138	0.497784309814214	0.66066128897784	0.670664760049463	0.650657817906218	0.737002326787941	0.747109791976368	NA	NA	0.501112601160268	0.5836107819371	NA	NA	p.Val120Ile	1	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.064	-2.663	0.599	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120K	120	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val120Lys	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.064	-3.255	1.191	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120L	120	V	L	missense	possibly_wt-like	0.729250380674557	0.443236360407245	6	0.180950486407682	0.374593944330495	1.08390681701862	1.36800083294805	1.1211837518373	0.154963801735795	0.594879315937994	NA	NA	0.465847447031672	0.670627134556526	0.606321041389061	0.764662908463688	0.699740737108997	0.46488870882553	0.590158694215372	NA	NA	0.581558902560079	0.62248338856275	NA	NA	p.Val120Leu	1	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.064	-2.217	0.153	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120M	120	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val120Met	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.064	-3.836	1.772	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120N	120	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val120Asn	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.064	-3.946	1.882	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120P	120	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val120Pro	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.064	-3.66	1.596	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120Q	120	V	Q	missense	wt-like	0.945840812415429	0.149521436461565	6	0.0610418708231352	0.826200944053138	1.06548068077772	0.769230002215599	1.19571067379082	0.864354582174608	1.00151677489531	NA	NA	0.861736532236182	0.982496309180057	0.684886149973644	0.637125458092683	0.715854334784182	0.677149073286656	0.72483859533486	NA	NA	0.662995296293274	0.692623226660632	NA	NA	p.Val120Gln	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.064	-3.269	1.205	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120R	120	V	R	missense	possibly_wt-like	0.806162142316755	0.201829811770891	6	0.0823966756201095	0.644667625655511	0.967656658977999	1.09903668890396	0.963542349233246	0.69228343489163	0.862236677551658	NA	NA	0.607603170409707	0.612270532910326	0.645659807470741	0.707373876647222	0.665656810496572	0.62566280444491	0.678708487729292	NA	NA	0.610718774186709	0.609358902642177	NA	NA	p.Val120Arg	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.064	-3.029	0.965	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120S	120	V	S	missense	wt-like	0.845701942365925	0.119333992048848	6	0.0487178982481703	0.750216616397024	0.941187268334826	0.922012310004673	1.04529612544738	0.819033411935026	0.734089437834583	NA	NA	0.814990187338401	0.738790181635484	0.658483817568537	0.669667901707347	0.683332939119774	0.663588299199759	0.636265625681891	NA	NA	0.653379335937315	0.637813358548234	NA	NA	p.Val120Ser	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.064	-3.439	1.375	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120T	120	V	T	missense	wt-like	0.941803766926325	0.0884944065030934	6	0.0361276901705021	0.870994795347519	1.01261273850513	0.899428241914694	0.93586871509701	0.847021005476784	0.923767247939171	NA	NA	1.10907188643236	0.935665504697924	0.677026758316621	0.664857522985863	0.659673445089911	0.671962607083897	0.699087650920173	NA	NA	0.713873433734356	0.682090909549345	NA	NA	p.Val120Thr	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.064	-3.086	1.022	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120V	120	V	V	synonymous	wt-like	0.97953139475689	0.165637581564447	6	0.067621259510254	0.846996161527556	1.11206662798622	0.897824597580023	0.810869196756375	1.11200516577163	0.800284405396857	NA	NA	1.06395200010457	1.19225300293189	0.684553996437434	0.664515948715293	0.632647078035746	0.751249843388007	0.658189655280037	NA	NA	0.704592044159574	0.739797816959466	NA	NA	p.Val120=	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120W	120	V	W	missense	possibly_low	0.577062883454866	0.35018910373079	6	0.142964102937168	0.296858390615941	0.857267376293792	0.410695643797914	1.21639950126148	0.399698717592892	0.30573030990363	NA	NA	0.376036808856327	0.753816319316959	0.561921239674855	0.560758080799003	0.720327502781666	0.538117067395481	0.494391423680676	NA	NA	0.563084398550708	0.641192759110945	NA	NA	p.Val120Trp	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.064	-4.513	2.449	0.00881026	NA	NA	NA	NA	NA	NA	NA
V120X	120	V	X	nonsense	low	0.00317816583414173	0.152802378794804	6	0.0623813099217903	-0.119086954920998	0.125443286589282	-0.1190182340229	-0.139275835177747	-0.0609324864931979	-0.049717545072434	NA	NA	0.164184932255623	0.223828163515506	0.437572107896928	0.447929676448104	0.427214539345752	0.400289300306373	0.376665717632686	NA	NA	0.519505392509006	0.521997639918475	NA	NA	p.Val120Ter	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V120Y	120	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val120Tyr	0	7.7	20	14.2	0.934	20.8	-144.1	-104.8	135.3	7.27272727272727	-5.6	0	1	13.7	0	0	0	0	8	15.4640474300021	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.064	-3.017	0.953	0.00881026	NA	NA	NA	NA	NA	NA	NA
F121A	121	F	A	missense	possibly_low	0.563996131183589	0.224050743893912	6	0.0914683331718462	0.38472149244086	0.743270769926318	0.75024625429045	0.894193110129862	0.392711612780511	0.593484503453349	NA	NA	0.43534307521647	0.317998231230893	0.582490362702389	0.633081943137391	0.650662688792618	0.536026420808438	0.589696726919014	NA	NA	0.575283998485764	0.543176627265323	NA	NA	p.Phe121Ala	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.984	-3.221	1.237	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121C	121	F	C	missense	wt-like	1.19289307660773	0.085793349485219	2	0.0606650592017057	1.0739917454524	1.31179440776307	1.25355813580944	1.13222801740603	NA	NA	NA	NA	NA	NA	0.721207696032676	0.740286754754287	0.702128637311065	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe121Cys	1	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.984	-3.884	1.9	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121D	121	F	D	missense	possibly_low	0.654933931757622	0.312971934432204	6	0.127770257195116	0.404508829359776	0.905359034155468	0.210508971969605	0.327767553615696	0.701821365529308	0.930825411902741	NA	NA	0.934905144463636	0.823775143064749	0.642721649155473	0.518118565958228	0.528194816896545	0.628516696388792	0.701425342157808	NA	NA	0.67804645111657	0.656926601922155	NA	NA	p.Phe121Asp	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.984	-3.374	1.39	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121E	121	F	E	missense	low	-0.130124327956741	0.226992740571989	6	0.0926693982862215	-0.311753011066733	0.0515043551532511	-0.23547939485178	-0.259434748227863	0.137521140009582	0.18271034684152	NA	NA	-0.319064873748367	-0.286998437763536	0.42161102382912	0.42312359245568	0.401234768127175	0.45966960274568	0.453646735516895	NA	NA	0.42009845520256	0.407111982645503	NA	NA	p.Phe121Glu	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.984	-3.073	1.089	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121G	121	F	G	missense	low	0.0342958340289867	0.138716637710041	6	0.0566308302040195	-0.0766985535854945	0.145290221643468	0.142402689335758	0.262556003635383	-0.0837034938152709	-0.0129568056925636	NA	NA	-0.0797651675645694	-0.0227582217248167	0.467931808333275	0.503612011537829	0.514095312279766	0.393475873283343	0.3888410168721	NA	NA	0.46932361907126	0.466539997595291	NA	NA	p.Phe121Gly	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.984	-3.372	1.388	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121H	121	F	H	missense	low	0.239590263709176	0.440017643562117	6	0.179636450758172	-0.112490710087443	0.591671237505796	0.772357610839429	0.837354010508361	-0.00685112795818448	0.00129895257329425	NA	NA	-0.0624378921841778	-0.104179971523662	0.460558026661917	0.637791634882146	0.638373406483443	0.416471254159923	0.393562579215501	NA	NA	0.472887927542841	0.448228125780992	NA	NA	p.Phe121His	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.984	-3.448	1.464	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121I	121	F	I	missense	possibly_low	0.706875457745279	0.12756551891175	6	0.0520784050178574	0.604803659537988	0.808947255952569	0.654508724339854	0.919097863834956	0.680893812825981	0.709044186827098	NA	NA	0.530109841409497	0.747598317234286	0.625112700102427	0.612689967028968	0.65604738966157	0.622254858644947	0.627970541559907	NA	NA	0.594778003177836	0.639794321256683	NA	NA	p.Phe121Ile	1	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.984	-2.989	1.005	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121K	121	F	K	missense	low	0.456502514526694	0.113185154511883	6	0.0462076458353645	0.365937192878997	0.54706783617439	0.353409485261277	0.467845755346097	0.542103657205026	0.630421018147136	NA	NA	0.343903563915694	0.401331607284932	0.560199899708731	0.548556199500987	0.558481372768997	0.580726761821504	0.601930243623092	NA	NA	0.556474427008909	0.561918426648465	NA	NA	p.Phe121Lys	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.984	-4.173	2.189	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121L	121	F	L	missense	possibly_wt-like	0.815484409591886	0.272368737419482	6	0.111194071427304	0.597548034299995	1.03342078488378	0.971136099981786	1.26628657312525	0.694400721206655	0.821329603547027	NA	NA	0.506111866231142	0.633641593459451	0.645728117340643	0.680131208543082	0.731113674867336	0.626296328275904	0.665159906405382	NA	NA	0.589841497907896	0.614165285731192	NA	NA	p.Phe121Leu	1	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.984	-2.505	0.521	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121M	121	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe121Met	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.984	-3.791	1.807	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121N	121	F	N	missense	low	0.257653452243935	0.255277276996384	6	0.104216511928044	0.0533928422705807	0.461914062217289	-0.106667656487774	-0.00508603640094717	0.333467288569144	0.464037152454899	NA	NA	0.520260635518284	0.339909329810004	0.532561446572661	0.450560334270084	0.456227953195743	0.518299630164811	0.546823262980511	NA	NA	0.592751971547028	0.548104465705082	NA	NA	p.Phe121Asn	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.984	-3.709	1.725	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121P	121	F	P	missense	low	-0.392611634232392	0.123248457241777	3	0.0711575299657459	-0.532077830194084	-0.2531454382707	-0.512274307200791	-0.266065863507756	NA	NA	NA	NA	NA	-0.399494731988629	0.381811399883245	0.364166616623248	0.399801042958375	NA	NA	NA	NA	NA	0.381811399883245	NA	NA	p.Phe121Pro	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.984	-4.612	2.628	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121Q	121	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe121Gln	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.984	-3.634	1.65	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121R	121	F	R	missense	low	0.259287927806388	0.203672708458519	6	0.0831490350423351	0.0963188137741528	0.422257041838624	0.637331103922861	0.293742273766931	0.153420256020193	0.274015300013875	NA	NA	0.109767816520599	0.0874508165938718	0.49981884439618	0.609031155011114	0.520838150930781	0.464426856789684	0.483887289588091	NA	NA	0.50831151566713	0.49132617312523	NA	NA	p.Phe121Arg	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.984	-3.104	1.12	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121S	121	F	S	missense	low	0.170777137911373	0.329524913498338	6	0.134527982600949	-0.0928928628993181	0.434447138722064	0.686286472443243	0.396971038236241	0.0629103477919693	0.178765377506668	NA	NA	-0.085516052856411	-0.214754355653474	0.460240389590271	0.619458588283748	0.543157424765844	0.437344934332245	0.452340146396209	NA	NA	0.468140632784333	0.423359783438405	NA	NA	p.Phe121Ser	1	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.984	-3.038	1.054	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121T	121	F	T	missense	low	0.131651795366048	0.346964139202184	6	0.141647516681557	-0.145972235829341	0.409275826561437	0.616751817543797	0.522137482560247	-0.0526488009273524	-0.0366109959054728	NA	NA	-0.0430716510659139	-0.216647080009017	0.449902884273992	0.604647792327882	0.570219883182259	0.402767903307388	0.381006657472194	NA	NA	0.476871661613267	0.422934106934718	NA	NA	p.Phe121Thr	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.984	-2.746	0.762	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121V	121	F	V	missense	possibly_low	0.690578010360149	0.148421746844403	6	0.0605929244168878	0.571818060785091	0.809337959935207	0.689412536125791	0.887503331761642	0.805862734653965	0.686891793574845	NA	NA	0.610469884388667	0.463327781655982	0.620379009565866	0.620124436002619	0.649216279973683	0.659647434958264	0.620633583129113	NA	NA	0.611308471799085	0.575861457851606	NA	NA	p.Phe121Val	1	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.984	-2.795	0.811	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121W	121	F	W	missense	possibly_low	0.676444604879441	0.137908493500993	6	0.0563009067122274	0.566096855426526	0.786792354332356	0.803651476078198	0.853944921531677	0.687622755699451	0.618836844439336	NA	NA	0.620136281846732	0.474475349681252	0.618782579057113	0.644457189682009	0.641960556714352	0.624268259306677	0.598093520431092	NA	NA	0.613296898807549	0.578368562368817	NA	NA	p.Phe121Trp	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.984	-3.238	1.254	0.007574819	NA	NA	NA	NA	NA	NA	NA
F121X	121	F	X	nonsense	low	0.195628639540424	0.103719882553442	6	0.0423434647395555	0.112636973670254	0.278620305410595	0.304875550765	0.215842873134156	0.051757875735295	0.115420131639903	NA	NA	0.172805431713043	0.313069974255149	0.512637028331988	0.538218531157062	0.503995383672562	0.434007947372917	0.431359955659228	NA	NA	0.521278672991413	0.542068254990953	NA	NA	p.Phe121Ter	0	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F121Y	121	F	Y	missense	wt-like	1.00791069595583	0.107255223920528	6	0.0437867618088744	0.922090219810803	1.09373117210086	1.09616159548876	1.03287879199348	0.798691349995709	1.00406776209389	NA	NA	1.04489122851968	1.07077344764347	0.703716316004405	0.706761485286567	0.680648165480529	0.657501649076594	0.725683492173786	NA	NA	0.700671146722243	0.712476885513073	NA	NA	p.Phe121Tyr	1	7.2	19.1	17.9	0.914	16.8	-163.2	-103.6	120	0	-6.8	0	1	13.57	0	0	0	0	7	15.8443858485381	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.984	-2.039	0.055	0.007574819	NA	NA	NA	NA	NA	NA	NA
K122A	122	K	A	missense	low	0.540230005253125	0.195754768822881	6	0.0799165497220899	0.383596446029124	0.696863564477125	0.679694512244348	0.81096228302294	0.472383066509942	0.607662563505825	NA	NA	0.38892129192509	0.281756314310603	0.580063678706229	0.618054508870451	0.632667204382161	0.559865315071056	0.594392555313255	NA	NA	0.565734802099203	0.535025766609683	NA	NA	p.Lys122Ala	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.131	-3.111	0.98	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122C	122	K	C	missense	wt-like	0.871370701773354	0.0758044892759813	6	0.0309470531564056	0.810715592159152	0.932025811387555	1.00705924169076	0.865775115020528	0.903847210997593	0.812900090950094	NA	NA	0.805230657021473	0.833411894959677	0.660730970424759	0.687782793536417	0.644518383782775	0.688965860336397	0.662368019189799	NA	NA	0.651371751027188	0.65909392165972	NA	NA	p.Lys122Cys	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.131	-3.737	1.606	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122D	122	K	D	missense	low	0.045881658725665	0.407144177906076	6	0.166215914602471	-0.279895547552563	0.371658865003893	0.606591647925176	0.499962487600637	-0.0599721807147263	-0.140817509904225	NA	NA	-0.341423835238912	-0.289050657313959	0.411074769401053	0.602483688697598	0.56542538828213	0.400576638202711	0.346493056493707	NA	NA	0.415499103365242	0.406650435436864	NA	NA	p.Lys122Asp	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.131	-3.165	1.034	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122E	122	K	E	missense	possibly_low	0.526324393075979	0.25119587066027	6	0.102550284768637	0.325329528325124	0.727319257826834	0.809352511476713	0.721353281542071	0.510286861789642	0.657655013217709	NA	NA	0.185954140679798	0.273344549749943	0.591078473771094	0.645671503208792	0.613292683603773	0.571206699287456	0.610950248254732	NA	NA	0.523983429147918	0.533133948333271	NA	NA	p.Lys122Glu	1	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.131	-2.477	0.346	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122F	122	K	F	missense	possibly_wt-like	0.800033190547904	0.11012955690772	6	0.0449602033371193	0.711912811269552	0.888153569826255	0.692473859915163	0.691530118005569	0.800703245512724	0.829291483623746	NA	NA	0.795321820095903	0.990878616134317	0.653718545694835	0.620776494203883	0.606844564641767	0.658103638399651	0.667796911919354	NA	NA	0.64933345299002	0.694508419877846	NA	NA	p.Lys122Phe	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.131	-4.015	1.884	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122G	122	K	G	missense	low	0.505670109322067	0.141155045913962	6	0.0576263061847231	0.392724624637932	0.618615594006202	0.746295166939667	0.580358352801052	0.500377750886741	0.453803961160323	NA	NA	0.369349524827459	0.383835899317164	0.564975267465659	0.632240366392085	0.582807920562155	0.568241744639421	0.543433990395481	NA	NA	0.561708790291897	0.557983616080064	NA	NA	p.Lys122Gly	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.131	-3.222	1.091	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122H	122	K	H	missense	low	0.424415977802479	0.269655876564007	6	0.11008655062079	0.208650303403484	0.640181652201473	0.535155756671851	0.386370457929405	0.190674593817705	0.357468819870347	NA	NA	0.902248965185444	0.174577273340121	0.526196436539793	0.587267931737152	0.540865454539375	0.475573913583637	0.511527418540212	NA	NA	0.671328909327948	0.510921041959577	NA	NA	p.Lys122His	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.131	-2.769	0.638	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122I	122	K	I	missense	possibly_wt-like	0.951818182603665	0.370272253856563	3	0.213776785437536	0.532823382415347	1.37081298279198	1.16866718344741	1.16250796437677	NA	NA	NA	NA	NA	0.524279399986806	0.708675518227693	0.722205086329366	0.708675518227693	NA	NA	NA	NA	NA	0.589569566858174	NA	NA	p.Lys122Ile	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.131	-3.572	1.441	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122L	122	K	L	missense	possibly_wt-like	0.744112886813772	0.152882288277514	6	0.0624139328314984	0.621783826330533	0.866441947297011	0.971396239744045	0.883882844962771	0.698084841237667	0.711502490045678	NA	NA	0.57871560329646	0.62109530159601	0.628091706683793	0.680186617992434	0.648433488116242	0.627398672261849	0.628784741105736	NA	NA	0.604776455043929	0.611343606156438	NA	NA	p.Lys122Leu	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.131	-3.577	1.446	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122M	122	K	M	missense	possibly_low	0.708590692408266	0.38594476644969	6	0.157561291116561	0.399776236462177	1.01740514835436	1.19492707160602	1.20050379658557	0.380154838459696	0.437546989946544	NA	NA	0.437974237595662	0.600437220256106	0.591261407541822	0.727798410203675	0.716890664345338	0.532269245543003	0.538049618573986	NA	NA	0.575825241938781	0.606697573144863	NA	NA	p.Lys122Met	1	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.131	-4.28	2.149	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122N	122	K	N	missense	possibly_low	0.625191555415749	0.278612708069515	6	0.113743161770887	0.402259054857097	0.8481240559744	1.03281688148328	0.906154572641982	0.541640696101192	0.482102119322875	NA	NA	0.460825525369884	0.327609537575284	0.580557052352188	0.693269139126588	0.653248897768849	0.580588236913455	0.552806449964181	NA	NA	0.58052586779092	0.545338224260982	NA	NA	p.Lys122Asn	1	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.131	-3.751	1.62	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122P	122	K	P	missense	low	0.362853853808285	0.274049266487111	6	0.111880144546239	0.143572799912522	0.582134907704049	0.152319793448229	0.118184650041649	0.755111483457296	0.199026282666377	NA	NA	0.656391543194761	0.2960893700414	0.521986817266052	0.505724342514308	0.482880526445967	0.644461899181777	0.459050636645921	NA	NA	0.620754790041183	0.538249292017795	NA	NA	p.Lys122Pro	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.131	-4.44	2.309	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122Q	122	K	Q	missense	wt-like	0.957343911477039	0.233287661089444	6	0.0952392888260787	0.770678335464717	1.14400948748936	0.869647557941854	0.703091233779796	1.08554895941031	1.34014620921173	NA	NA	0.978918710917139	0.766710797601404	0.672807269506746	0.65851427393421	0.609344213941362	0.743333749523582	0.836993975330658	NA	NA	0.687100265079282	0.644092746326159	NA	NA	p.Lys122Gln	1	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.131	-2.286	0.155	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122R	122	K	R	missense	wt-like	0.964458406371333	0.112816893829321	6	0.0460573040412636	0.874187749225445	1.05472906351722	1.03150254453355	1.11259930875119	1.0043727193975	0.972520504547363	NA	NA	0.854237568060015	0.811517792938378	0.695436933225906	0.692989186973123	0.697884679478689	0.719044600628744	0.715234918306903	NA	NA	0.661452721309359	0.654169905770922	NA	NA	p.Lys122Arg	1	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.131	-2.186	0.055	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122S	122	K	S	missense	wt-like	0.867579352515487	0.103811044029232	6	0.0423806812562029	0.784514743613058	0.950643961417916	0.924256446783931	0.855548635267954	0.903163513204758	0.700832223494812	NA	NA	1.00494725268962	0.816728043651851	0.662743799467107	0.670145900080715	0.642307298499135	0.688761287699298	0.625250707503239	NA	NA	0.692454468201576	0.655341698853498	NA	NA	p.Lys122Ser	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.131	-3.224	1.093	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122T	122	K	T	missense	wt-like	1.05197074865693	0.125840612497359	6	0.0513742149229723	0.951279137673885	1.15266235963998	1.02711592006772	0.903079410539794	0.932211195480372	1.21068911624274	NA	NA	1.05701372415882	1.18171512545213	0.700308797813443	0.692054841358085	0.652584011529062	0.697452790037063	0.794117284813788	NA	NA	0.703164805589823	0.737427832746638	ND	*19	p.Lys122Thr	1	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.131	-2.974	0.843	0.008282424	NA	NA	1.125	0.64	NA	NA	NA
K122V	122	K	V	missense	wt-like	1.00756834466377	0.096046572835489	6	0.0392108491650013	0.930716492497138	1.08442019683041	1.05673725762745	1.1080294276365	1.04703503458026	1.05458152029487	NA	NA	0.920921358237282	0.858105469606272	0.697630383607992	0.698364149819765	0.696896617396219	0.731809805391972	0.742413844505631	NA	NA	0.675169915330236	0.664647543077614	NA	NA	p.Lys122Val	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.131	-3.054	0.923	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122W	122	K	W	missense	possibly_low	0.601593690442182	0.161529337447661	6	0.0659440758727679	0.472345676737781	0.730841704146584	0.845976200858084	0.695735234738341	0.666934320113185	0.434001021149573	NA	NA	0.511779576176544	0.455135789617368	0.599380567487872	0.653472303994571	0.607753760371752	0.618077968991718	0.536875179976585	NA	NA	0.591007374603993	0.574019066740072	NA	NA	p.Lys122Trp	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.131	-3.743	1.612	0.008282424	NA	NA	NA	NA	NA	NA	NA
K122X	122	K	X	nonsense	low	0.0663331061779199	0.0606469934843566	6	0.0247590314117616	0.0178062963187712	0.114859916037069	0.0548011530219343	0.132210979761286	0.0189687441415514	0.114066941972265	NA	NA	-0.0238681262657278	0.101818944436211	0.48288745808848	0.484952992065585	0.485913184015035	0.424196947266393	0.430911774001049	NA	NA	0.480821924111374	0.494557586303041	NA	NA	p.Lys122Ter	1	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K122Y	122	K	Y	missense	possibly_wt-like	0.841937935138875	0.228346640961453	6	0.0932221258056787	0.659225925997483	1.02464994428027	0.885659131145613	0.948488921045193	0.866331433030341	1.17676651976054	NA	NA	0.537447159847944	0.636934446003624	0.662163400740095	0.661924719330053	0.662402082150138	0.677740576721285	0.782881989492854	NA	NA	0.596287326813244	0.614905853132915	NA	NA	p.Lys122Tyr	0	7.3	22.1	20.2	0.9	17.6	-127.4	-114.3	120.8	30.4347826086957	-5.6	0	1	15.16	0	0	1	12	6	18.2092034474351	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.131	-2.858	0.727	0.008282424	NA	NA	NA	NA	NA	NA	NA
S123A	123	S	A	missense	possibly_low	0.656016672970884	0.270098170994582	6	0.110267116565954	0.439897095822533	0.872136250119235	0.855734530149	1.01873924787462	0.467652090257451	0.795760656052853	NA	NA	0.343003218023128	0.455210295468253	0.61479331967269	0.655550816129376	0.677591029625866	0.558449735997714	0.65669137197898	NA	NA	0.556289221290077	0.574035823216004	NA	NA	p.Ser123Ala	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.16	-2.288	0.128	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123C	123	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Cys	1	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.16	-3.278	1.118	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123D	123	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Asp	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.16	-3.596	1.436	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123E	123	S	E	missense	wt-like	1.05613490652501	0.306893556465869	6	0.125288769781566	0.810573430085814	1.30169638296421	1.03951113295132	1.03091628276636	1.28418874371607	1.51445757376161	NA	NA	0.744489025328543	0.72324668062617	0.687459427171072	0.694695006454382	0.680223847887763	0.802769753170456	0.89472657429431	NA	NA	0.638876889159534	0.634317602208789	NA	NA	p.Ser123Glu	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.16	-3.174	1.014	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123F	123	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Phe	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.16	-2.773	0.613	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123G	123	S	G	missense	wt-like	0.938920287686875	0.0678072127300723	6	0.0276821786781715	0.884664214464056	0.993176360909694	0.903922849789378	1.07015670414706	0.939356533010306	0.886543140936272	NA	NA	0.936977154143865	0.896565344094369	0.682615778275823	0.66581486893415	0.688708088832634	0.699590782227155	0.68675888252961	NA	NA	0.678472674022036	0.673297225666848	NA	NA	p.Ser123Gly	1	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.16	-2.887	0.727	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123H	123	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123His	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.16	-3.226	1.066	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123I	123	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Ile	1	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.16	-3.648	1.488	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123K	123	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Lys	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.16	-3.418	1.258	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123L	123	S	L	missense	low	-0.000167421725547535	0.410489360850355	6	0.167581579820761	-0.328621282646563	0.328286439195468	0.611925060261059	0.190420102206593	0.0466827152153895	0.0397064110884456	NA	NA	-0.571798902247933	-0.317939916876839	0.419386330706232	0.60361969896427	0.498498681383279	0.432489383202986	0.406283278209478	NA	NA	0.368109783062142	0.400153198283003	NA	NA	p.Ser123Leu	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.16	-3.193	1.033	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123M	123	S	M	missense	low	0.327089841534674	0.153344336008757	6	0.0626025630278911	0.204391072660109	0.449788610409239	0.338430172481175	0.34907352523009	0.581391103665963	0.357823091617803	NA	NA	0.186224521998111	0.149596634214903	0.52842023333927	0.545365624305553	0.532801418721418	0.59248215523018	0.511644754714894	NA	NA	0.524039047957123	0.50530285931636	NA	NA	p.Ser123Met	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.16	-5.082	2.922	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123N	123	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Asn	1	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.16	-2.922	0.762	0.008283858	NA	NA	NA	NA	8.21e-06	NA	NA
S123P	123	S	P	missense	low	0.0306343548634598	0.551266018498831	6	0.225053409642968	-0.410462222634697	0.471730932361617	0.856887761313929	0.580593009801165	-0.138696321022571	-0.292100791603574	NA	NA	-0.484355715306167	-0.338521814002023	0.390810794776597	0.655796452948864	0.582858656167388	0.377021194328326	0.296387447746928	NA	NA	0.386097290339329	0.395524299213865	NA	NA	p.Ser123Pro	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.16	-4.508	2.348	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123Q	123	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Gln	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.16	-3.2	1.04	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123R	123	S	R	missense	low	0.139972936868126	0.270227461270492	6	0.110319899100068	-0.0762500921461004	0.356195965882353	0.618521838210624	0.279744487872202	0.0700024789394627	0.0241704979685777	NA	NA	-0.0277493066877228	-0.124852375094387	0.461801208641192	0.605024804552534	0.517811664872606	0.439467006374458	0.401137723621	NA	NA	0.480023545603838	0.443578871678547	NA	NA	p.Ser123Arg	1	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.16	-3.167	1.007	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123S	123	S	S	synonymous	wt-like	1.20364738362433	0.0984618861469557	6	0.0401968966953422	1.12486291381119	1.28243185343748	1.18819062310249	1.07436202282886	1.18455910692032	1.31843249004474	NA	NA	1.31975986477417	1.13658019407541	0.742244970000086	0.726363554959234	0.689617328226377	0.772959071102788	0.82980230745568	NA	NA	0.757213019998097	0.727276920002076	NA	NA	p.Ser123=	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123T	123	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser123Thr	1	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.16	-2.959	0.799	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123V	123	S	V	missense	low	0.537428570391597	0.218679075682461	6	0.0892753588075824	0.362452082421845	0.712405058361349	0.775575699847225	0.802828522813438	0.535351576247959	0.449119713834172	NA	NA	0.233900466005457	0.427795443601332	0.573288310214566	0.63847708388209	0.630908589694115	0.578706437898022	0.541882549541206	NA	NA	0.533846231567093	0.56787018253111	NA	NA	p.Ser123Val	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.16	-2.855	0.695	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123W	123	S	W	missense	possibly_low	0.650362326458729	0.27045612675136	6	0.110413251391721	0.43395633031499	0.866768322602468	0.869977282249476	1.03011166402184	0.537985801429715	0.697661843443967	NA	NA	0.471805124621394	0.294632242985978	0.60349254621253	0.658584504806125	0.680049879845192	0.57949463759355	0.62420066535303	NA	NA	0.58278442707203	0.537921581990414	NA	NA	p.Ser123Trp	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.16	-3.371	1.211	0.008283858	NA	NA	NA	NA	NA	NA	NA
S123X	123	S	X	nonsense	low	-0.22344455941847	0.163453278944592	6	0.0667295216998424	-0.354232018655745	-0.0926571001811948	-0.195061318442915	-0.289776484811093	-0.327329709104167	-0.142149003179952	NA	NA	0.0404330189602937	-0.426783859932987	0.385174281131679	0.431732593010669	0.394674527569091	0.320579254557176	0.346052060764549	NA	NA	0.494048995975243	0.375674034694267	NA	NA	p.Ser123Ter	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S123Y	123	S	Y	missense	possibly_low	0.681425100557028	0.236928782689496	6	0.0967257704946708	0.491846074010587	0.87100412710347	0.908014772755183	1.01004255432188	0.623538356969594	0.611892670531335	NA	NA	0.571591274947954	0.363470973816222	0.604202095151274	0.666686443492208	0.675710702123536	0.605093245751726	0.59579358314129	NA	NA	0.603310944550822	0.553403514249751	NA	NA	p.Ser123Tyr	0	7.8	21.9	23.9	0.348	20.7	-127.3	-57.1	140.3	4.1958041958042	-5.7	0	1	15.46	2	5	0	0	8	19.3480066910614	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.16	-2.376	0.216	0.008283858	NA	NA	NA	NA	NA	NA	NA
S124A	124	S	A	missense	wt-like	1.30769955587149	0.419321137335668	5	0.187526113497016	0.940155127256568	1.67524398448641	1.10178025114156	0.75712760910815	1.48063364233312	NA	NA	NA	1.31875322361086	1.88020305316375	0.757005948802686	0.707958252028851	0.621027514271536	0.86154901408951	NA	NA	NA	0.757005948802686	0.894518799566806	NA	NA	p.Ser124Ala	1	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.245	-2.513	0.268	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124C	124	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser124Cys	1	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.245	-3.642	1.397	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124D	124	S	D	missense	wt-like	1.07983107283491	0.128130341457657	6	0.0523089928566396	0.977307330768331	1.18235481490148	1.12313857352794	1.18558569529654	1.07701183769462	1.07279643732332	NA	NA	0.838063595001356	1.18239029816567	0.725622437677278	0.712507548423315	0.713665195267209	0.740779314624243	0.748446695563134	NA	NA	0.658125652977696	0.737579680087347	NA	NA	p.Ser124Asp	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.245	-2.699	0.454	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124E	124	S	E	missense	possibly_wt-like	0.82926913549954	0.172682970694303	6	0.0704975275781705	0.691096520447206	0.967441750551873	1.06539302689564	0.999321387199203	0.835420397228903	0.750283937969275	NA	NA	0.698582531369418	0.626613532334801	0.655060418946434	0.700207818026036	0.673392659608228	0.668491531052795	0.641629306840072	NA	NA	0.629433690403412	0.612584664401688	NA	NA	p.Ser124Glu	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.245	-2.493	0.248	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124F	124	S	F	missense	wt-like	0.87780292605825	0.156048284315685	8	0.0551714000160735	0.769668969050094	0.985936883066407	1.00356091678798	0.896407128550277	0.705730163548571	0.940728108151959	0.991271083688612	0.668350003763609	0.731927383284887	1.0844486206901	0.651033084110591	0.687037654635573	0.651141385633127	0.629686267399654	0.704705153503965	0.650924782588056	0.608423735986975	0.636292895648134	0.715552452133626	NA	NA	p.Ser124Phe	1	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.245	-3.457	1.212	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124G	124	S	G	missense	wt-like	1.07654826372933	0.067891650272004	6	0.0277166501603161	1.02222462764301	1.13087189981564	1.02813113939155	0.981727555560549	1.08839222502913	1.18108251657162	NA	NA	1.10186897848267	1.07808716734044	0.713256755448018	0.692271081825193	0.669588666136352	0.744184497254103	0.78431146435048	NA	NA	0.712391759018539	0.714121751877496	NA	NA	p.Ser124Gly	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.245	-3.494	1.249	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124H	124	S	H	missense	possibly_wt-like	0.848540966287507	0.416342026381986	6	0.169970920518706	0.515404083651723	1.18167784892329	0.213815503600184	0.441454316231835	1.23564864043415	1.0249973033158	NA	NA	1.05053250143691	1.12479753270616	0.713229283620536	0.518822853128027	0.552775233016954	0.788245826023802	0.732615437276608	NA	NA	0.701831585187494	0.724626982053578	NA	NA	p.Ser124His	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.245	-3.33	1.085	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124I	124	S	I	missense	wt-like	0.938166786856317	0.174953582578947	6	0.0714245009983835	0.798177337285741	1.07815623642689	0.745913480489236	0.784444066752449	1.17764257868056	0.972381245820216	NA	NA	0.849170010630403	1.09944933876505	0.687799547154186	0.632159067647673	0.626933653916831	0.770889542085129	0.715188795277189	NA	NA	0.660410299031184	0.718926135789276	NA	NA	p.Ser124Ile	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.245	-3.483	1.238	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124K	124	S	K	missense	wt-like	1.21012340918626	0.280980514577572	6	0.11470981472995	0.985296303642295	1.43495051473023	0.854082844234517	0.918248619987523	1.31830872568802	1.38273771555484	NA	NA	1.58591515562528	1.20144739402737	0.776914081504528	0.655199009061404	0.655863773146532	0.812978963676818	0.851100447168078	NA	NA	0.811962513909321	0.741865649099736	NA	NA	p.Ser124Lys	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.245	-2.686	0.441	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124L	124	S	L	missense	wt-like	0.933683253613814	0.110328561801856	6	0.0450414467449444	0.845403640182144	1.02196286704548	0.780607754962164	0.834578291810039	1.04108175292217	0.906334747885305	NA	NA	1.03573643207401	1.0037605420292	0.695359761718341	0.639548905431414	0.637773263431887	0.730028494203089	0.693313939394579	NA	NA	0.698787958638107	0.697405584042104	NA	NA	p.Ser124Leu	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.245	-2.996	0.751	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124M	124	S	M	missense	possibly_wt-like	1.15579433521369	0.342782005898101	2	0.242383480839274	0.680731442321263	1.63085722810613	NA	1.39817781605297	NA	NA	NA	NA	NA	0.91341085437442	0.718357959852257	NA	0.759630113889771	NA	NA	NA	NA	NA	0.677085805814743	NA	NA	p.Ser124Met	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.245	-3.766	1.521	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124N	124	S	N	missense	possibly_low	0.573181552087661	0.546869434340076	6	0.223258511676276	0.135602909960145	1.01076019421518	1.31799329144663	1.14638472197242	0.410099491735543	0.368633380955737	NA	NA	-0.11645572079858	0.31243414721422	0.541577195805694	0.754011363640417	0.705189483456456	0.541229135061248	0.51522516440671	NA	NA	0.461776186087827	0.541925256550139	NA	NA	p.Ser124Asn	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.245	-3.679	1.434	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124P	124	S	P	missense	wt-like	1.15770954773665	0.16714009455259	2	0.118185894266297	0.926069451494047	1.38934964397925	NA	1.03952365347035	1.27589544200294	NA	NA	NA	NA	NA	0.741186567806403	NA	0.682084862738903	0.800288272873904	NA	NA	NA	NA	NA	NA	NA	p.Ser124Pro	1	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.245	-3.368	1.123	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124Q	124	S	Q	missense	wt-like	1.22457967578875	0.276527338300774	6	0.112891813127813	1.00331578790881	1.44584356366869	1.09794888214549	0.925422410339853	1.15330452925867	1.16338595645049	NA	NA	1.74051629040534	1.26689998613268	0.760096633156532	0.707142175145827	0.657414831053038	0.763607232555581	0.77845029510803	NA	NA	0.843764751844331	0.756586033757484	NA	NA	p.Ser124Gln	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.245	-2.941	0.696	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124R	124	S	R	missense	possibly_wt-like	0.729878725347266	0.0904406142325869	6	0.0369222261489553	0.65751249186627	0.802244958828261	0.69118503076752	0.810636693925595	0.668123332138331	0.874392280174167	NA	NA	0.681436324399901	0.653498690678081	0.623204301901823	0.620501975180882	0.632596808187276	0.618433739228329	0.682734470390715	NA	NA	0.625906628622764	0.618631176230598	NA	NA	p.Ser124Arg	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.245	-2.771	0.526	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124S	124	S	S	synonymous	wt-like	1.20713991254829	0.0746851786291887	5	0.0334002272653161	1.14167667003282	1.27260315506377	1.31305158387942	1.15916356996552	1.16557362120911	1.25782288396848	NA	NA	1.14008790371895	NA	0.752958786007619	0.752958786007619	0.70795242079394	0.767278328939718	0.80972817121114	NA	NA	0.720253585878437	NA	NA	NA	p.Ser124=	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124T	124	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser124Thr	1	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.245	-2.605	0.36	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124V	124	S	V	missense	wt-like	1.10266421657639	0.0987740386280843	6	0.040324332412127	1.023629977348	1.18169845580478	0.999374614895025	1.01199585603317	1.23353454865761	1.184082796266	NA	NA	1.03887265223945	1.14812483136706	0.714653210512258	0.686145977482131	0.676133028943011	0.787613258046648	0.785305168603912	NA	NA	0.69943309504063	0.729873325983886	NA	NA	p.Ser124Val	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.245	-3.107	0.862	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124W	124	S	W	missense	wt-like	0.899798402897175	0.0828990942884435	6	0.0338434135242597	0.83346653127573	0.96613027451862	0.903806017630581	0.985775076789043	0.986623553330257	0.913797290879581	NA	NA	0.826919395240216	0.781869083513373	0.668126885845765	0.665789983828047	0.670463787863483	0.713733783851588	0.69578556253315	NA	NA	0.655833234536503	0.647501867221132	NA	NA	p.Ser124Trp	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.245	-4.28	2.035	0.008985109	NA	NA	NA	NA	NA	NA	NA
S124X	124	S	X	nonsense	low	0.0402823815746618	0.280598709299886	6	0.114553943378045	-0.184239221733347	0.264803984882671	-0.356776979216605	-0.247044842343293	0.190135069285012	0.171556511800021	NA	NA	0.369323339201234	0.114501190721603	0.462682510953333	0.397287356199602	0.403913611603119	0.475412479748996	0.449952542157671	NA	NA	0.561703403775705	0.497409842228137	NA	NA	p.Ser124Ter	0	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S124Y	124	S	Y	missense	wt-like	0.995664963054197	0.155627970375207	2	0.110045593194608	0.77997956373542	1.21135036237297	0.885619369859589	1.1057105562488	NA	NA	NA	NA	NA	NA	0.679155750167576	0.661916250225042	0.696395250110111	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser124Tyr	1	5.1	23.8	25.8	0.824	109	67.5	-58.6	-30.5	52.4475524475524	-3.5	0	0	18.23	0	0	0	0	6	23.1363444745411	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.245	-3.303	1.058	0.008985109	NA	NA	NA	NA	NA	NA	NA
S125A	125	S	A	missense	possibly_wt-like	0.825535991468079	0.15191332357328	6	0.0620183546474753	0.703982249978595	0.947089732957563	1.06066466243997	0.942630773767737	0.820113324647369	0.732491860061701	NA	NA	0.751139916880985	0.646175411010713	0.650690246531115	0.699200682213553	0.661135481760955	0.663911425285168	0.635736501736856	NA	NA	0.640245011301274	0.616984159814709	NA	NA	p.Ser125Ala	1	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.271	-2.143	-0.128	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125C	125	S	C	missense	wt-like	1.06603153016795	0.217998435815616	6	0.0889974887455213	0.891599657512218	1.24046340282368	0.949411031307388	0.92897970379325	1.31928412370637	1.17960962710659	NA	NA	1.25622529802269	0.762679397071401	0.709823716428401	0.675503795640423	0.658183959765429	0.813270817397755	0.783823637655866	NA	NA	0.74414363721638	0.643186078391364	NA	NA	p.Ser125Cys	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.271	-3.711	1.44	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125D	125	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser125Asp	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.271	-2.338	0.067	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125E	125	S	E	missense	wt-like	0.96770630697314	0.202470137071083	5	0.0905473979809283	0.790236668036706	1.14517594590957	1.31233617512999	0.977271223295497	0.85892741081768	NA	NA	NA	0.884798266093817	0.805198459528713	0.668625154651592	0.752806404824048	0.668625154651592	0.675525182193088	NA	NA	NA	0.667739211972662	0.652748678351523	NA	NA	p.Ser125Glu	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.271	-2.562	0.291	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125F	125	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser125Phe	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.271	-3.523	1.252	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125G	125	S	G	missense	wt-like	0.799543315753903	0.0894856155971289	6	0.0365323495886343	0.727941226289553	0.871145405218253	0.675828127434722	0.695203833923523	0.832307988765357	0.859754328464323	NA	NA	0.870557418617387	0.863608197318107	0.665347456025974	0.617230973662215	0.607638865261236	0.667560251745196	0.677886324098614	NA	NA	0.664809797382751	0.665885114669198	NA	NA	p.Ser125Gly	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.271	-2.913	0.642	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125H	125	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser125His	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.271	-2.939	0.668	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125I	125	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser125Ile	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.271	-4.306	2.035	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125K	125	S	K	missense	possibly_wt-like	0.891944758983909	0.264777864058739	6	0.108095110354653	0.680082235783906	1.10380728218391	0.787979371505277	0.896699724361119	0.876224305781535	1.39984669904024	NA	NA	0.649196213519551	0.741722239695731	0.646161849489047	0.641119050686939	0.651204648291154	0.680700672670709	0.856767008753369	NA	NA	0.619274674214883	0.638472782737519	NA	NA	p.Ser125Lys	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.271	-3.256	0.985	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125L	125	S	L	missense	wt-like	1.00883151596107	0.127225881230508	6	0.0519397485151134	0.907031479505376	1.11063155241676	0.952611395908598	1.03696179641072	1.04849137085616	1.16814505515415	NA	NA	0.790299905823073	1.05647957161369	0.695396565384145	0.676185469363568	0.681530959090689	0.732245563055062	0.780026527028401	NA	NA	0.648300419740807	0.709262171677601	rs200220210	*12	p.Ser125Leu	1	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.271	-3.119	0.848	0.008160365	1.121405751	0.0519615242270663	1.155	0.4	0.000152	25.25	0.863769101
S125M	125	S	M	missense	wt-like	1.23771334820368	0.229830622793562	5	0.102783379175504	1.03626162681037	1.43916506959699	1.43576727880118	1.36642923623852	1.30506863727247	0.849220276656439	NA	NA	NA	1.23208131204978	0.752765697267177	0.779097078067843	0.752765697267177	0.809017330582513	0.674397405346487	NA	NA	NA	0.748755262518533	NA	NA	p.Ser125Met	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.271	-5.14	2.869	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125N	125	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser125Asn	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.271	-2.875	0.604	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125P	125	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser125Pro	1	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.271	-3.403	1.132	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125Q	125	S	Q	missense	possibly_wt-like	0.870835843295168	0.199300720330932	6	0.0813641783633195	0.711364984071369	1.03030670251897	0.677243602254653	0.905439033775542	1.04457781807486	1.10878311094651	NA	NA	0.600968014011628	0.888003480707803	0.662232919893549	0.617532468057621	0.65309418984435	0.731074569348064	0.76036562122635	NA	NA	0.609353888846068	0.671371649942749	NA	NA	p.Ser125Gln	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.271	-2.956	0.685	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125R	125	S	R	missense	possibly_low	0.653728823081395	0.315798317034569	3	0.182326243349539	0.296375952679813	1.01108169348298	0.881494524199955	NA	0.293227509938017	NA	NA	NA	NA	0.786464435106212	0.648535368583085	0.661037663173698	NA	0.506259284683024	NA	NA	NA	NA	0.648535368583085	NA	NA	p.Ser125Arg	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.271	-3.531	1.26	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125T	125	S	T	missense	wt-like	1.24714354694627	0.30328463073183	6	0.123815432020234	1.00446975945634	1.48981733443619	1.01731102716957	0.888932481765866	1.10486973120739	1.27026425073746	NA	NA	1.66370891923224	1.53777487156507	0.781481807189165	0.68996641123222	0.649525279025058	0.749114814313826	0.813848800064505	NA	NA	0.827965085841331	0.817506195655321	NA	NA	p.Ser125Thr	1	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.271	-2.715	0.444	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125V	125	S	V	missense	possibly_wt-like	0.917220735197083	0.273376840797736	6	0.111605627908087	0.698477724025253	1.13596374636891	0.495428401476063	0.663076654787442	1.15175197626463	1.07869365135556	NA	NA	1.13106872580921	0.983305001489602	0.705601698985529	0.578806053950861	0.600692591009358	0.763142685406891	0.750399875687706	NA	NA	0.718398295215326	0.692805102755731	NA	NA	p.Ser125Val	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.271	-2.972	0.701	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125W	125	S	W	missense	wt-like	1.11566054869921	0.246214727325448	6	0.10051674151764	0.918651355481309	1.3126697419171	0.8510415548615	0.753929365817788	1.22868486721281	1.28730604060841	NA	NA	1.25798414573643	1.3150173179583	0.755956566942568	0.654551218166179	0.620336016430254	0.78616216059884	0.819493106864482	NA	NA	0.744505441116225	0.767407692768911	NA	NA	p.Ser125Trp	1	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.271	-5.832	3.561	0.008160365	NA	NA	NA	NA	NA	NA	NA
S125X	125	S	X	nonsense	low	-0.415563781842277	0.25813044781917	6	0.105381314038847	-0.622107362001923	-0.209020201682631	-0.144831695863076	-0.315958451938026	-0.396057659068733	-0.285130968354587	NA	NA	-0.896158991565374	-0.455244924263864	0.335330183015793	0.44243144083045	0.389013678126102	0.300014820805837	0.298695880197792	NA	NA	0.301387266750929	0.369273099280657	NA	NA	p.Ser125Ter	1	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S125Y	125	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser125Tyr	0	8	25.6	27.6	0.676	106.1	-129.2	-61.7	-20.7	44.7552447552448	-0.9	0	0	19.37	1	2	0	0	5	23.5292745939469	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.271	-3.504	1.233	0.008160365	NA	NA	NA	NA	NA	NA	NA
G126A	126	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Ala	1	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.717	-2.787	1.07	0.007580668	NA	NA	NA	NA	8.13e-06	NA	NA
G126C	126	G	C	missense	wt-like	1.02333192202098	0.272274166576092	4	0.136137083288046	0.756508141816078	1.29015570222588	NA	NA	1.14636732568042	1.3309426047532	NA	NA	0.708235142783892	0.907782614866393	0.718675761800617	NA	NA	0.761531517166458	0.833945705892826	NA	NA	0.631419281552752	0.675820006434776	NA	NA	p.Gly126Cys	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.717	-5.547	3.83	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126D	126	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Asp	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.717	-2.394	0.677	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126E	126	G	E	missense	possibly_wt-like	0.80135737330148	0.368959170184206	6	0.150626950478668	0.506133975262193	1.09658077134077	1.27967319314411	0.994428130313192	0.527122151996436	1.05645550008469	NA	NA	0.299737189037348	0.650728075233098	0.645171370300996	0.745849229841263	0.672334679878008	0.576244070696333	0.743034513869048	NA	NA	0.547389179577794	0.618008060723984	NA	NA	p.Gly126Glu	1	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.717	-2.711	0.994	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126F	126	G	F	missense	possibly_wt-like	0.815582154415775	0.245495991028122	6	0.100223318652963	0.619148059444887	1.01201624938666	0.952633492754361	0.976551467010704	0.438575655332092	0.747887981795499	NA	NA	0.666241559996686	1.11160276960531	0.654652645874265	0.676190175964533	0.668469534871608	0.549749630435771	0.640835756876923	NA	NA	0.622780988480439	0.721659460339543	NA	NA	p.Gly126Phe	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.717	-4.019	2.302	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126G	126	G	G	synonymous	wt-like	0.981603184702724	0.197352886345204	6	0.0805689784685386	0.823690888633205	1.13951548077224	0.751049663418306	0.94738354095954	0.757496317091582	1.09311066072826	NA	NA	1.22752612078607	1.11305280523259	0.692074330730023	0.633253068293314	0.662163085965786	0.645175477184694	0.755174845022143	NA	NA	0.73824007082719	0.721985575494259	NA	NA	p.Gly126=	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126H	126	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126His	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.717	-3.543	1.826	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126I	126	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Ile	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.717	-3.848	2.131	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126K	126	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Lys	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.717	-2.562	0.845	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126L	126	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Leu	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.717	-2.936	1.219	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126M	126	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Met	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.717	-3.97	2.253	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126N	126	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Asn	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.717	-2.9	1.183	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126P	126	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Pro	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.717	-2.694	0.977	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126Q	126	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Gln	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.717	-3.066	1.349	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126R	126	G	R	missense	possibly_wt-like	0.778216838279527	0.188105324231393	6	0.0767936770446167	0.627703997031678	0.928729679527376	1.06434376396038	0.920757418633165	0.738905426966201	0.616485646397551	NA	NA	0.767172856466552	0.561635917253312	0.64157793613643	0.699984326311571	0.656406204941167	0.639612803941	0.597314794534584	NA	NA	0.64354306833186	0.59797110277828	NA	NA	p.Gly126Arg	1	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.717	-3.169	1.452	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126S	126	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Ser	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.717	-2.991	1.274	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126T	126	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Thr	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.717	-3.194	1.477	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126V	126	G	V	missense	possibly_wt-like	0.733462138635247	0.316441925354053	6	0.129186875056885	0.480260516248476	0.986663761022018	1.20050094038632	0.962725697192328	0.497995095793082	0.796074133160987	NA	NA	0.342071785591611	0.601405179687156	0.631855232731008	0.728985637397212	0.665480240713693	0.567528818488545	0.656795196811141	NA	NA	0.556097620912437	0.606915268650875	NA	NA	p.Gly126Val	1	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.717	-3.479	1.762	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126W	126	G	W	missense	low	0.527750064000509	0.117259733157424	6	0.0478710856017669	0.433924460320211	0.621575667680806	0.497757986164451	0.550070846502212	0.74274284820706	0.423228734427846	NA	NA	0.426746854087564	0.525953114613918	0.577780828926792	0.579302252623761	0.576259405229823	0.640761017948901	0.533307356898423	NA	NA	0.57351571217873	0.589945987750394	NA	NA	p.Gly126Trp	1	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.717	-5.814	4.097	0.007580668	NA	NA	NA	NA	NA	NA	NA
G126X	126	G	X	nonsense	low	0.154369391786319	0.481476394095238	6	0.196561914788086	-0.230884881930561	0.539623665503198	-0.28653415736267	-0.557953121312633	0.257530418789686	0.604105808728468	NA	NA	0.275374524725172	0.633692877149888	0.51897791767612	0.412248990845627	0.336691582437327	0.495578179449798	0.593214544357381	NA	NA	0.542377655902441	0.614176819508933	NA	NA	p.Gly126Ter	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G126Y	126	G	Y	missense	possibly_wt-like	0.80930583748928	0.219898303930934	2	0.155491581880984	0.504547937103391	1.11406373787517	0.653814255608296	0.964797419370264	NA	NA	NA	NA	NA	NA	0.639235108737629	0.612542046043443	0.665928171431814	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly126Tyr	0	8.8	27.3	24.3	0.474	84.9	96.6	86.6	2.4	61.8556701030928	-2	0	0	17.66	0	0	0	0	5	22.5772206037431	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.717	-4.009	2.292	0.007580668	NA	NA	NA	NA	NA	NA	NA
N127A	127	N	A	missense	possibly_wt-like	0.746685422248608	0.230164916763106	6	0.0939644337932952	0.562518516186051	0.930852328311165	0.905341762222992	1.11152353397729	0.752315796654244	0.648071690248053	NA	NA	0.577116263916423	0.485743486472644	0.625700801161151	0.666117095537042	0.69765208431118	0.643625387746757	0.607776214575545	NA	NA	0.604447462817739	0.580902782979645	NA	NA	p.Asn127Ala	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.076	-2.608	0.532	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127C	127	N	C	missense	wt-like	0.942746702775366	0.070965492415204	6	0.0289715409604333	0.88596352591629	0.999529879634443	0.830853960965852	0.949935428909149	0.93133044063096	0.908930608833432	NA	NA	1.01084011316342	1.02458966414939	0.693920179048501	0.650251285500075	0.662714834175082	0.697189254972198	0.694173698593129	NA	NA	0.693666659503874	0.702090084377845	NA	NA	p.Asn127Cys	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.076	-5.604	3.528	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127D	127	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127Asp	1	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.076	-2.374	0.298	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127E	127	N	E	missense	wt-like	1.00757618421325	0.129404893730954	4	0.0647024468654769	0.880761718645301	1.1343906497812	0.869204901638166	1.14137952930423	NA	NA	NA	NA	0.928692118794316	1.0910281871163	0.690437851050799	0.658419988686056	0.704107301892695	NA	NA	NA	NA	0.676768400208903	0.717032206342886	NA	NA	p.Asn127Glu	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.076	-2.594	0.518	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127F	127	N	F	missense	possibly_wt-like	0.763847314306637	0.150018404279729	6	0.061244757085316	0.643809796177513	0.883884832435761	0.604183164198239	0.994861514864594	0.740331376816269	0.891564749847189	NA	NA	0.649675605933523	0.702467474180008	0.634841898755736	0.601970684626545	0.672428382718765	0.640039469529593	0.6884220588472	NA	NA	0.619373287667074	0.629644327981878	NA	NA	p.Asn127Phe	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.076	-4.849	2.773	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127G	127	N	G	missense	possibly_wt-like	0.7614244471995	0.110825614443729	6	0.0452443676362595	0.672747116129142	0.850101778269858	0.887595704929289	0.900708052372444	0.698608006409249	0.768905982743435	NA	NA	0.659139195983395	0.653589740759187	0.637676105656887	0.662337207163709	0.652071295983446	0.627555211130207	0.647797000183567	NA	NA	0.621319996162543	0.618651653528347	NA	NA	p.Asn127Gly	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.076	-2.464	0.388	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127H	127	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127His	1	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.076	-3.505	1.429	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127I	127	N	I	missense	low	0.637939849161857	0.100841840643891	6	0.041168509050098	0.557251054126454	0.718628644197261	0.675379019978119	0.789674432979943	0.534963184812922	0.698119935286042	NA	NA	0.537536066384793	0.591966455529326	0.610963899985178	0.617135314326426	0.628064520654307	0.578590225353642	0.624352387145096	NA	NA	0.596305615339023	0.60479248564393	NA	NA	p.Asn127Ile	1	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.076	-4.532	2.456	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127K	127	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127Lys	1	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.076	-2.749	0.673	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127L	127	N	L	missense	wt-like	0.975897924314542	0.155223148414843	6	0.0633695849807781	0.851695820036966	1.10010002859212	1.01445819598844	1.1186536534654	1.08487313453548	1.03949001134838	NA	NA	0.698784443015696	0.899128107533852	0.694276230881446	0.689358761700036	0.699193700062855	0.743131532581666	0.73741547830034	NA	NA	0.629475224653635	0.673873594950364	NA	NA	p.Asn127Leu	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.076	-3.331	1.255	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127M	127	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127Met	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.076	-4.368	2.292	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127N	127	N	N	synonymous	wt-like	1.67050757001489	0.126680780579572	4	0.0633403902897861	1.5463626862802	1.79465245374959	NA	NA	NA	NA	1.81389212949664	1.67585600881512	1.50532375308594	1.68695838866188	0.798691026916494	NA	NA	NA	NA	0.771204096281795	0.80199760038046	0.795384453452528	0.851057789039547	NA	NA	p.Asn127=	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	0	-3.5	-3.5	0	187	187	0	11.6	11.6	0	132	132	0	5.47	5.47	0	NA	NA	NA	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127P	127	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127Pro	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.076	-2.766	0.69	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127Q	127	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127Gln	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.076	-2.798	0.722	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127R	127	N	R	missense	wt-like	0.998675410907666	0.120026203025734	6	0.0490004921961245	0.902636210978526	1.09471461083681	0.926757824727673	1.17189950801793	1.09215023195086	0.904906186111897	NA	NA	1.03249250792456	0.86384620671308	0.695480730591313	0.670678690505675	0.710706080497216	0.745308949306271	0.692840794203088	NA	NA	0.698120666979537	0.665938643333739	NA	NA	p.Asn127Arg	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.076	-2.702	0.626	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127S	127	N	S	missense	wt-like	1.31036759561767	0.118209466390582	6	0.0482588125706007	1.21578206104263	1.40495313019272	1.3562511201526	1.11084470724057	1.37650112414943	1.38817182566261	NA	NA	1.4087023715569	1.22173442494393	0.768834589533426	0.762160234092107	0.697505313981212	0.830391002354068	0.852900245479483	NA	NA	0.775508944974745	0.746428232322947	NA	NA	p.Asn127Ser	1	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.076	-2.59	0.514	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127T	127	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127Thr	1	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.076	-2.767	0.691	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127V	127	N	V	missense	wt-like	0.859210527233446	0.103627569437038	6	0.042305778067596	0.776292725883014	0.942128328583879	0.895475794844762	1.04344221272923	0.827280475802222	0.855747412100524	NA	NA	0.778355960889692	0.754961307034247	0.665035800530577	0.664015656622051	0.682932101370379	0.666055944439104	0.676559217882048	NA	NA	0.645843489659444	0.641450268540056	NA	NA	p.Asn127Val	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.076	-4.173	2.097	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127W	127	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn127Trp	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.076	-4.571	2.495	0.008221482	NA	NA	NA	NA	NA	NA	NA
N127X	127	N	X	nonsense	low	0.0605039474418841	0.128898027171405	6	0.0526223992368905	-0.0426340598425094	0.163641954726278	0.274469683627262	0.161472251912149	-0.0459850255115913	-0.0362658401533542	NA	NA	-0.00421048902289324	0.0135431037997315	0.479784909588542	0.531742118860352	0.492239815446254	0.404761804888067	0.381120974393919	NA	NA	0.484865599843289	0.474704219333794	NA	NA	p.Asn127Ter	0	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N127Y	127	N	Y	missense	possibly_wt-like	1.0070541486339	0.374640219775243	5	0.167544199704581	0.678673551394338	1.33543474587347	0.805910516933703	NA	0.443162974510137	1.24909826970651	NA	NA	1.20672645504974	1.33037252696943	0.733961474039032	0.644938362605283	NA	0.551122225157158	0.806838545181309	NA	NA	0.733961474039032	0.770861101959801	NA	NA	p.Asn127Tyr	1	12.5	26.3	24.6	0.561	74.6	49.5	-105.6	-12.8	36.3636363636364	-3.8	0	0	16.99	0	0	0	0	6	20.3575842290933	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.076	-4.786	2.71	0.008221482	NA	NA	NA	NA	NA	NA	NA
I128A	128	I	A	missense	low	0.377388282625895	0.148183131053753	4	0.0740915655268766	0.232171482635028	0.522605082616763	0.227027334289609	0.27514278144143	0.524988860741693	0.482394154030849	NA	NA	NA	NA	0.53727006490139	0.521636956812406	0.516816721782228	0.575605757947253	0.552903172990373	NA	NA	NA	NA	NA	NA	p.Ile128Ala	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.481	-3.577	2.096	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128C	128	I	C	missense	possibly_low	0.633829379951116	0.215763827177503	6	0.088085213589156	0.461185533745852	0.80647322615638	0.838743947538747	0.731632528107054	0.495418425276774	0.540838443769939	NA	NA	0.323520024977534	0.872822910036648	0.59388766288605	0.651931842934274	0.615515177693298	0.566757840012409	0.572260148078803	NA	NA	0.552281429614736	0.667957517172514	NA	NA	p.Ile128Cys	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.481	-3.602	2.121	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128D	128	I	D	missense	low	-0.0543808210240348	0.471195981881616	6	0.192364954076611	-0.431409202901894	0.322647560853824	-0.501776741468828	-0.705823452223532	0.311068032100463	0.451503012132289	NA	NA	-0.128027033278711	0.246771256594109	0.485496672483732	0.366402585210627	0.304720276526145	0.511597436574475	0.542671907166919	NA	NA	0.45939590839299	0.527157575445737	NA	NA	p.Ile128Asp	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.481	-4.453	2.972	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128E	128	I	E	missense	low	0.180873163873806	0.135241220370337	6	0.0552119970164367	0.0726596382070577	0.289086689540555	0.304341031548298	0.158158016270838	0.365889702477719	-0.0108852113494181	NA	NA	0.145470071664574	0.122265372630828	0.507405834463985	0.53810467922144	0.491523238693518	0.528000902838085	0.389527136940846	NA	NA	0.515655650718405	0.499156018209566	NA	NA	p.Ile128Glu	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.481	-4.317	2.836	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128F	128	I	F	missense	low	0.548358110358439	0.208642402288162	6	0.0851779040524159	0.381412486137096	0.715303734579782	0.802130690242625	0.81359186810919	0.517951351646553	0.413767644371284	NA	NA	0.346773062841852	0.395934044939129	0.56710226827283	0.644133264169819	0.63323575162686	0.573500029642596	0.530173807233403	NA	NA	0.557064697499056	0.560704506903063	NA	NA	p.Ile128Phe	1	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.481	-2.796	1.315	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128G	128	I	G	missense	low	0.0504246358668982	0.205193652246424	6	0.0837699577436389	-0.113761464297076	0.214610736030873	-0.00466597047598573	0.111981643788425	0.264022798608664	0.258005344709606	NA	NA	-0.271896316001066	-0.0548996854282544	0.47543564915306	0.472286567913719	0.481539363487386	0.497520796896481	0.4785847303924	NA	NA	0.42980126688415	0.45931133492573	NA	NA	p.Ile128Gly	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.481	-3.417	1.936	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128H	128	I	H	missense	low	0.181360293074191	0.0883904312649396	6	0.0360852424572752	0.110634517484536	0.252086068663846	0.17312772964589	0.143199952730506	0.17178615357397	0.0607090433852234	NA	NA	0.330063794081192	0.209275085028364	0.499222768316975	0.510156407327629	0.488289129306321	0.469922208880402	0.413239431359342	NA	NA	0.553627516125177	0.51872463106742	NA	NA	p.Ile128His	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.481	-5.249	3.768	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128K	128	I	K	missense	low	-0.164350409744887	0.173477759138845	6	0.0708219986019352	-0.303158976317826	-0.0255418431719481	-0.254962011187598	-0.400997502297899	-0.146699585392706	-0.184405835816392	NA	NA	-0.12443401288438	0.125396489109652	0.396800158349405	0.418973819142596	0.370627234566371	0.374626497556214	0.332056434154813	NA	NA	0.46013501092059	0.499860210931259	NA	NA	p.Ile128Lys	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.481	-4.248	2.767	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128L	128	I	L	missense	possibly_wt-like	0.735893047004858	0.277588444918011	6	0.1133250080903	0.51378011260016	0.958005981409557	0.940614657959734	1.20580488214327	0.629719231111754	0.527974712199165	NA	NA	0.516566497110635	0.594678301504588	0.606172519918192	0.673630178938188	0.71803682143434	0.606942656026401	0.567999630367469	NA	NA	0.591992068530973	0.605402383809983	NA	NA	p.Ile128Leu	1	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.481	-1.762	0.281	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128M	128	I	M	missense	possibly_wt-like	0.726468964042742	0.194119457467119	6	0.0792489366567238	0.571143902382468	0.881794025703017	0.40032617387483	0.664796735605866	0.837594940211598	0.680883931080693	NA	NA	0.810528223325003	0.964683780158464	0.635552621551677	0.558549396461338	0.601064492726891	0.669142186937775	0.618643755805466	NA	NA	0.652461487297889	0.688617162569185	NA	NA	p.Ile128Met	1	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.481	-2.926	1.445	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128N	128	I	N	missense	low	-0.0598227655608952	0.14162492117021	5	0.0633365902089276	-0.183960201273965	0.064314670152175	0.131688974046207	0.014308472666124	-0.0540717492434991	-0.17104669501097	NA	NA	NA	-0.219992830262339	0.422181642760061	0.501330003360579	0.460421274320818	0.402342135822775	0.336481033323146	NA	NA	NA	0.422181642760061	NA	NA	p.Ile128Asn	1	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.481	-4.566	3.085	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128P	128	I	P	missense	low	0.159110279052361	0.282598416560095	3	0.163158271873533	-0.160674057599558	0.47889461570428	0.14950643779886	0.446388198158905	NA	NA	NA	NA	NA	-0.118563798800682	0.505125101221828	0.505125101221828	0.55384199635919	NA	NA	NA	NA	NA	0.444993181777129	NA	NA	p.Ile128Pro	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.481	-3.825	2.344	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128Q	128	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile128Gln	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.481	-4.659	3.178	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128R	128	I	R	missense	low	0.109588083858739	0.0815317586158168	6	0.0332852010734195	0.0443502885366627	0.174825879180815	0.0180069459920433	0.0538751764053571	0.213662939671582	0.20528585120081	NA	NA	0.0695744239472173	0.0971231659354231	0.479784121393267	0.477115871230432	0.468976061351803	0.482452371556101	0.461123829984847	NA	NA	0.500043530856718	0.493501498781129	NA	NA	p.Ile128Arg	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.481	-3.851	2.37	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128S	128	I	S	missense	low	0.154693830574432	0.207498450227867	6	0.0847108875794276	-0.0113364581796674	0.320724119328532	-0.264927159379736	0.188899016127938	0.244811538851269	0.274553430641221	NA	NA	0.233769980681775	0.251056176524126	0.494971152211039	0.416851254836249	0.498169804670564	0.491772499751515	0.484065520535791	NA	NA	0.533819390073875	0.52812126026812	NA	NA	p.Ile128Ser	1	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.481	-4.078	2.597	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128T	128	I	T	missense	low	0.168047651077538	0.341989182814629	6	0.139616499241206	-0.105595659082789	0.441690961237866	0.779326531492445	0.347941423830167	0.0622636018216253	0.00462597389692544	NA	NA	-0.044781265542085	-0.141090359033848	0.458223455171186	0.639276006408455	0.532556645074423	0.437151418234821	0.394664501561854	NA	NA	0.47651998524022	0.439926925102151	NA	NA	p.Ile128Thr	1	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.481	-3.492	2.011	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128V	128	I	V	missense	wt-like	1.01434314422852	0.12076346240895	6	0.0493014770789507	0.917714024769151	1.11097226368789	0.941686242901738	0.883276630316207	1.00978770039411	1.02023222360646	NA	NA	0.993215983532683	1.23786008461993	0.705353065395124	0.67385842521263	0.648302417374777	0.720664844183615	0.731037224423996	NA	NA	0.690041286606634	0.750054917006553	NA	NA	p.Ile128Val	1	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.481	-1.982	0.501	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128W	128	I	W	missense	low	0.140150241599922	0.0669021983835749	6	0.0273127081183687	0.0866183173676645	0.193682165832179	0.181306563601801	0.253898611200856	0.0958917237762936	0.129697308246709	NA	NA	0.0718937289585143	0.108213513815358	0.498258179034894	0.511898488899085	0.51222348214175	0.447213456844663	0.436088611840094	NA	NA	0.500520623666664	0.495995734403123	NA	NA	p.Ile128Trp	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.481	-4.201	2.72	0.007350051	NA	NA	NA	NA	NA	NA	NA
I128X	128	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile128Ter	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I128Y	128	I	Y	missense	possibly_low	0.548621146149208	0.292009646190303	6	0.119212438856149	0.314969059481973	0.782273232816443	0.979157128343249	0.84954832114737	0.327398868288611	0.463647569660157	NA	NA	0.379827125018962	0.292147864436902	0.555279158734617	0.681839677717045	0.641009959965227	0.516483867772674	0.546694231650225	NA	NA	0.56386408581901	0.537362841584548	NA	NA	p.Ile128Tyr	0	12.8	23.1	22.5	0.992	53.4	177.6	-135.9	124.9	0.523560209424084	-4	0	1	15.94	0	0	0	0	6	16.7284346713528	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.481	-3.06	1.579	0.007350051	NA	NA	NA	NA	NA	NA	NA
S129A	129	S	A	missense	wt-like	1.21690960507566	0.237874454882966	6	0.0971118395509944	1.02657389708327	1.40724531306804	0.783504385546225	1.13990086424435	1.42077113765595	1.26515380212769	NA	NA	1.26892017598097	1.42320726489875	0.769247404848295	0.640165884182543	0.703787597103516	0.843637254575983	0.812156199694619	NA	NA	0.746755038031513	0.791739771665077	NA	NA	p.Ser129Ala	1	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.305	-2.634	0.329	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129C	129	S	C	missense	possibly_low	0.63007085752023	0.114419095872784	6	0.046711400286485	0.538518195291285	0.721623519749174	0.648406540652544	0.791250655381133	0.559091902516178	0.733745556007652	NA	NA	0.503468099987227	0.544462390576642	0.602749480334174	0.611390209410142	0.628405318488883	0.585809899692382	0.636151730689122	NA	NA	0.589297661775948	0.594108751258207	NA	NA	p.Ser129Cys	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.305	-3.301	0.996	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129D	129	S	D	missense	possibly_wt-like	0.790881781798941	0.309900220362786	6	0.126516235177482	0.542914517391478	1.0388490462064	1.09386749589299	0.953428203776006	0.252815851227462	0.598779940208685	NA	NA	0.906844516028751	0.939554683659756	0.667872125332935	0.706272844894743	0.663470013209708	0.494167510102763	0.591450596079081	NA	NA	0.672274237456162	0.682965591643354	NA	NA	p.Ser129Asp	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.305	-2.524	0.219	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129E	129	S	E	missense	possibly_wt-like	0.822850226474519	0.278900778130473	6	0.113860765880807	0.599687226095991	1.04601322685305	1.11323565614129	1.14886092249978	0.576301811559998	0.45608469695107	NA	NA	0.782490815049401	0.860127456645579	0.655898170545957	0.710398239201982	0.705724867154255	0.590959362677684	0.544189378921578	NA	NA	0.646694050142074	0.66510229094984	NA	NA	p.Ser129Glu	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.305	-2.158	-0.147	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129F	129	S	F	missense	possibly_wt-like	0.762283427094221	0.440950568518858	5	0.197199089185069	0.375780314507384	1.14878653968106	1.42457833838088	NA	0.929725670994038	0.622673646236649	NA	NA	0.580696609302567	0.253742870556976	0.605183958031837	0.776713847522338	NA	0.696709083820554	0.599364284044464	NA	NA	0.605183958031837	0.528725501725167	NA	NA	p.Ser129Phe	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.305	-4.742	2.437	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129G	129	S	G	missense	possibly_low	0.585339777855128	0.23541690258994	6	0.0961085480286408	0.396970485112554	0.773709070597702	0.817656854072687	0.938483645418222	0.441503123777627	0.369084163191195	NA	NA	0.419869167256435	0.525441713414601	0.580965954981242	0.647440317966188	0.660238823801928	0.550625572915335	0.515374465228758	NA	NA	0.57210093709731	0.589830972865173	NA	NA	p.Ser129Gly	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.305	-3.572	1.267	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129H	129	S	H	missense	wt-like	1.47509081540931	0.16320411375452	6	0.0666278004369525	1.34450272618376	1.60567890463486	1.35829420557208	1.30305113593843	1.4722458918551	1.3726209263074	NA	NA	1.7017729281445	1.64255980463837	0.838433763764898	0.762595408773167	0.739062606050151	0.85903927330549	0.847749727391827	NA	NA	0.835795045627267	0.841072481902529	NA	NA	p.Ser129His	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.305	-3.677	1.372	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129I	129	S	I	missense	wt-like	1.04753345524071	0.0860192423549565	6	0.0351172086384077	0.978704991071855	1.11636191940957	1.19643300817647	0.974798249445273	1.08912630667884	1.04105755880524	NA	NA	0.963862493599101	1.01992311473936	0.714579871681143	0.728119172840661	0.668090468599368	0.744404145497085	0.737934656088415	NA	NA	0.684003124775424	0.701040570521624	NA	NA	p.Ser129Ile	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.305	-3.423	1.118	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129K	129	S	K	missense	wt-like	1.1917961832709	0.186778250443837	6	0.0762519014395278	1.04234520269672	1.34124716384507	1.04607728413747	0.883582570871773	1.32984329539998	1.34757376500182	NA	NA	1.23975625325543	1.30394393095891	0.752836571405474	0.696093588579712	0.648368565323675	0.816430279987201	0.839454010571715	NA	NA	0.74075587113694	0.764917271674007	NA	NA	p.Ser129Lys	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.305	-2.67	0.365	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129L	129	S	L	missense	possibly_wt-like	0.779397249352227	0.133117684472896	6	0.0543450671165676	0.672882875066342	0.885911623638111	0.781030470780468	0.867008697671105	0.876544760580946	0.880540521534978	NA	NA	0.535836643640612	0.735422401905249	0.642212021125631	0.639638943380711	0.64478509887055	0.68079655755446	0.684770791738621	NA	NA	0.595956035456964	0.637055939911675	NA	NA	p.Ser129Leu	1	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.305	-3.223	0.918	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129M	129	S	M	missense	possibly_wt-like	0.742786933688534	0.348386412031646	6	0.142228157132759	0.464024868120823	1.02154899925624	0.956937071784118	1.14040276664953	0.899498153613235	0.772199102467847	NA	NA	0.171839883415244	0.515844624201227	0.662997263596409	0.677106833003844	0.703896114310686	0.68766455711831	0.648887694188973	NA	NA	0.521080054806961	0.587672573323283	NA	NA	p.Ser129Met	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.305	-3.863	1.558	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129N	129	S	N	missense	wt-like	0.949710993508773	0.217028453222883	6	0.0886014950102584	0.776055254312261	1.12336673270528	1.09408747078616	1.20562633669811	0.977374715765758	0.681055759655873	NA	NA	0.691818999060977	1.04830267908576	0.706871437872356	0.706319699276387	0.717998217807695	0.71096639289245	0.618700666094976	NA	NA	0.628042397486576	0.707423176468325	NA	NA	p.Ser129Asn	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.305	-3.348	1.043	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129P	129	S	P	missense	low	0.0507148166330207	0.294336321540125	6	0.120162300090178	-0.184798963843222	0.286228597109263	-0.345503732038514	-0.290264894024198	0.145626292949678	0.345562930367899	NA	NA	0.181933348141485	0.266934954401774	0.484839463968863	0.399688543980805	0.394568927748858	0.462094786106554	0.507584141831173	NA	NA	0.523156331719606	0.531692420870558	NA	NA	p.Ser129Pro	1	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.305	-4.4	2.095	0.008753887	NA	NA	NA	NA	4.06e-06	NA	NA
S129Q	129	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser129Gln	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.305	-2.782	0.477	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129R	129	S	R	missense	wt-like	0.896254994329638	0.112283617405982	6	0.0458395948530908	0.806411039351672	0.986098949307603	0.989956925915208	1.06082770368595	0.787285758535473	0.910479781665114	NA	NA	0.843867816581538	0.785111979594542	0.671729816062169	0.684140021314554	0.686691049134743	0.654088924994182	0.694686790634189	NA	NA	0.659319610809784	0.648231199340525	NA	NA	p.Ser129Arg	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.305	-2.838	0.533	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129S	129	S	S	synonymous	wt-like	1.14941129139819	0.161526646736023	6	0.0659429773943419	1.02016543067194	1.27865715212444	0.984862317477518	1.01538189536548	1.35739214972214	1.30113854331052	NA	NA	1.21176688518722	1.02592595732624	0.718694467391495	0.683054875984434	0.676865130498838	0.824673310514453	0.824074485326103	NA	NA	0.734998316095562	0.702390618687427	NA	NA	p.Ser129=	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129T	129	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser129Thr	1	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.305	-2.239	-0.066	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129V	129	S	V	missense	wt-like	0.922090729495039	0.119686185180647	6	0.0488616804921405	0.82632359550634	1.01785786348374	0.821019604823813	0.941923978564426	1.07275134584162	1.05312158237349	NA	NA	0.844849333292453	0.798878532074431	0.660252089048589	0.648156579739506	0.660982664319334	0.739504511541883	0.741930307412426	NA	NA	0.659521513777845	0.651327317330611	NA	NA	p.Ser129Val	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.305	-2.865	0.56	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129W	129	S	W	missense	wt-like	1.23361547696971	0.357690108382396	6	0.146026375262947	0.947409040661401	1.51982191327801	0.914997379038835	0.856150870186929	1.0991921213418	1.20149707239616	NA	NA	1.71263689242505	1.61721852642947	0.769244416278275	0.668173730041007	0.642437508776655	0.747415988261149	0.791072844295401	NA	NA	0.838029818208072	0.835373190996618	NA	NA	p.Ser129Trp	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.305	-4.542	2.237	0.008753887	NA	NA	NA	NA	NA	NA	NA
S129X	129	S	X	nonsense	low	0.345076760969322	0.508306796234961	8	0.179713591270475	-0.00715540545315951	0.697308927391805	0.020576677232199	-0.464702957780596	0.91995793743845	0.810500607749475	-0.106360851181914	0.296136893728489	0.884802926665121	0.399702853903357	0.549230953773315	0.477663220823443	0.356853365306041	0.693786431395912	0.6615733010617	0.490434826140518	0.536909789939842	0.667740170675829	0.561552117606788	NA	NA	p.Ser129Ter	1	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S129Y	129	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser129Tyr	0	11.6	22.4	19	0.998	10	-163.7	-126	124.4	18.8811188811189	-5.3	0	1	14.36	0	0	0	0	6	15.3035931374745	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.305	-4.733	2.428	0.008753887	NA	NA	NA	NA	NA	NA	NA
L130A	130	L	A	missense	low	0.494753656266032	0.213832923558354	6	0.087296925487588	0.323654826349282	0.665852486182781	0.804103871788414	0.719246967527708	0.376348695357973	0.44162471871884	NA	NA	0.308537163517628	0.318660520685625	0.546262478062614	0.644553549411773	0.612837273723485	0.531130390423596	0.539400178134468	NA	NA	0.549199378983135	0.543325577142094	NA	NA	p.Leu130Ala	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.352	-3.472	2.12	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130C	130	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu130Cys	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.352	-5.112	3.76	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130D	130	L	D	missense	low	-0.165067381036433	0.543024561765428	6	0.221688849020624	-0.599569540890994	0.269434778818128	0.902563716120115	-0.291894543243919	-0.26151250725893	-0.271444120821658	NA	NA	-0.647042141181418	-0.421074689832789	0.364794951240932	0.665525375134529	0.394216578407306	0.340272748801406	0.303229017103327	NA	NA	0.352631866997892	0.376958035483972	NA	NA	p.Leu130Asp	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.352	-4.393	3.041	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130E	130	L	E	missense	low	0.0135450005286138	0.179709041959143	6	0.0733659091607186	-0.130249539119432	0.157339540176659	-0.199936520045111	-0.179275862173527	0.114013828316719	0.273047201597313	NA	NA	0.0263719357467581	0.0470494197295294	0.467437850846768	0.430694181066607	0.418566062726678	0.452635862408172	0.483566651643543	NA	NA	0.491156559806408	0.482239839285363	NA	NA	p.Leu130Glu	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.352	-4.24	2.888	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130F	130	L	F	missense	possibly_wt-like	0.84859833601596	0.204725568000791	6	0.0835788631505665	0.684786774372048	1.01240989765987	0.587180323649394	1.02888964817636	0.666099922940023	0.765238409552369	NA	NA	1.08637382220617	0.957807889571443	0.663183975688369	0.598349100505603	0.679785665636814	0.61782830483909	0.646582285739925	NA	NA	0.709204326743566	0.687070764618395	NA	NA	p.Leu130Phe	1	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.352	-3.327	1.975	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130G	130	L	G	missense	low	0.0233865091874123	0.0779442388012463	6	0.0318206022421159	-0.0389807251735094	0.085753743548334	-0.0112357233592704	0.103354724194432	0.0269291266660389	0.114420251885919	NA	NA	-0.0950209415587799	0.00187161729613444	0.468536323788904	0.470887218631329	0.479674121936145	0.426578813146935	0.431028791612652	NA	NA	0.466185428946479	0.472079284776821	NA	NA	p.Leu130Gly	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.352	-3.487	2.135	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130H	130	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu130His	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.352	-5.289	3.937	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130I	130	L	I	missense	possibly_wt-like	0.838962615221665	0.255105093878047	6	0.104146218464336	0.634839777905526	1.0430854525378	0.803979067100501	0.903964838782689	0.950040652298517	1.21456404008966	NA	NA	0.709144989440169	0.452082103618461	0.648651208851524	0.644526966166775	0.652775451536274	0.702787631011486	0.795400674597617	NA	NA	0.63160644162689	0.573332288247701	NA	NA	p.Leu130Ile	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.352	-1.427	0.075	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130K	130	L	K	missense	low	0.0774240346000412	0.119643292346297	6	0.048844169565844	-0.0183087786037804	0.173156847803863	0.0430491412309345	-0.00960774136826458	-0.0130479430037956	0.212131203001718	NA	NA	-0.0134265139219545	0.245446061661609	0.472920432510436	0.482449828010782	0.455250307363346	0.414617074127775	0.463391037010089	NA	NA	0.482969816755592	0.526859537147704	NA	NA	p.Leu130Lys	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.352	-4.153	2.801	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130M	130	L	M	missense	possibly_wt-like	0.890094932158767	0.241818956919379	6	0.0987221757640912	0.696603023185716	1.08358684113182	1.16887234663895	1.15477682038582	0.768885615469987	0.791167529716285	NA	NA	0.912636809340386	0.544230471401175	0.664317926166102	0.722248785836783	0.707003953904711	0.648583326132577	0.655170110749323	NA	NA	0.673465741582881	0.594056592293029	NA	NA	p.Leu130Met	1	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.352	-3.481	2.129	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130N	130	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu130Asn	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.352	-4.483	3.131	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130P	130	L	P	missense	low	0.285606303662501	0.252600695857021	6	0.103123802253611	0.0834873652965928	0.487725242028409	0.0555156414576021	0.0169308632212085	0.438612769692903	0.693185902937364	NA	NA	0.289798959864135	0.219593684801792	0.533195067403146	0.485105177223458	0.460988266023201	0.54976073560935	0.622718216524061	NA	NA	0.545344835406137	0.521045299400155	NA	NA	p.Leu130Pro	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.352	-4.487	3.135	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130Q	130	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu130Gln	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.352	-4.596	3.244	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130R	130	L	R	missense	low	0.191530651572302	0.282354634764899	6	0.115270796947318	-0.0343959589136715	0.417457262058276	-0.0987985647895179	-0.0280943373501498	0.441926373773047	0.615818675786034	NA	NA	0.0391364115477907	0.179195350466608	0.502870965789292	0.452236441121687	0.451253287733022	0.550752215663963	0.597093891285191	NA	NA	0.493782277250964	0.51195965432762	NA	NA	p.Leu130Arg	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.352	-3.706	2.354	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130S	130	L	S	missense	low	-0.038127500313298	0.200300203424948	6	0.0817722156277988	-0.198398097879827	0.122143097253231	0.122432607359856	0.210665816323023	-0.194111397141401	0.0888839116433146	NA	NA	-0.235916999598847	-0.220718940465734	0.429886725838206	0.49935840864306	0.502876043058331	0.360440172164001	0.422571056834242	NA	NA	0.43720239484217	0.422018339502633	NA	NA	p.Leu130Ser	1	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.352	-3.281	1.929	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130T	130	L	T	missense	low	0.274403354736703	0.160773679390187	6	0.0656355797626292	0.145759982297543	0.403046727175862	0.29500222999863	0.273669386454262	0.0861157518104395	0.526209575170079	NA	NA	0.347779023613669	0.117644161373138	0.526306841212119	0.536115525979442	0.516498156444797	0.444288339364069	0.567415010147903	NA	NA	0.557271628734484	0.498116700970785	NA	NA	p.Leu130Thr	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.352	-3.825	2.473	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130V	130	L	V	missense	wt-like	1.10245562932161	0.227770677724251	6	0.0929869897987211	0.920204478285328	1.2847067803579	0.706240615325479	0.968601185969313	1.25030864134454	1.30784942708305	NA	NA	1.23992716694751	1.1418067392598	0.734621703342959	0.623708796171173	0.666750590539176	0.79263231823944	0.826297156019615	NA	NA	0.740791028950688	0.728452377735231	NA	NA	p.Leu130Val	1	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.352	-1.942	0.59	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130W	130	L	W	missense	low	0.28796607205088	0.271081265389124	6	0.110668463171891	0.071059870009577	0.504872274092184	0.666714519324273	0.59699789991701	0.158752692331199	0.0322212348127408	NA	NA	0.152711876580996	0.120398209339063	0.50794070858227	0.61528978634575	0.586405586488718	0.466022401736208	0.403804158840448	NA	NA	0.517145326737657	0.498736090426883	NA	NA	p.Leu130Trp	1	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.352	-5.628	4.276	0.00634833	NA	NA	NA	NA	NA	NA	NA
L130X	130	L	X	nonsense	low	0.0816430374145922	0.29537576092173	6	0.120586649440759	-0.154702452505653	0.317988527334837	-0.217204947534127	-0.179747222219939	0.448119481204184	0.284771827329296	NA	NA	-0.149964514236914	0.303883599945053	0.471166575164899	0.427016027254118	0.418464149136945	0.552605286322235	0.487449893089856	NA	NA	0.454883257239943	0.540002225837561	NA	NA	p.Leu130Ter	1	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L130Y	130	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu130Tyr	0	12.2	19.1	17.3	0.943	9.9	-148.2	-113.9	115.1	0	-6.8	0	1	11.97	0	0	0	0	8	11.9822087510492	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.352	-4.362	3.01	0.00634833	NA	NA	NA	NA	NA	NA	NA
Y131A	131	Y	A	missense	low	0.285769680499083	0.309694236960958	6	0.126432142805821	0.0379672341114483	0.533572126886718	0.707620130467785	0.578449875474338	0.208725746374987	0.28824070661017	NA	NA	-0.0852889152579011	0.0168705393251205	0.484786944295148	0.624002631199481	0.582395285302187	0.4809750892493	0.488598799340995	NA	NA	0.468187356140938	0.475452564499082	NA	NA	p.Tyr131Ala	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.734	-3.419	1.685	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131C	131	Y	C	missense	possibly_low	0.609569058627241	0.268153395679757	6	0.109473165368341	0.395005597231695	0.824132520022786	0.863331442720213	1.01741301838816	0.515200670819481	0.504504598407444	NA	NA	0.410521906825946	0.346442714602199	0.571427571432833	0.657168949161739	0.67730428320176	0.572676984670812	0.560226237791101	NA	NA	0.570178158194854	0.549573833596631	NA	NA	p.Tyr131Cys	1	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.734	-5.381	3.647	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131D	131	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr131Asp	1	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.734	-4.432	2.698	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131E	131	Y	E	missense	low	-0.163603278407069	0.0986637972703617	6	0.0402793265662983	-0.242549307798542	-0.0846572490155973	-0.166086726119059	-0.235425411254857	-0.117662537634989	-0.152289128001417	NA	NA	-0.0116830009021557	-0.298472866529939	0.405478618012366	0.437904145532698	0.406425869359992	0.383314817886674	0.342693612155815	NA	NA	0.483328466231078	0.404531366664739	NA	NA	p.Tyr131Glu	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.734	-3.719	1.985	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131F	131	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr131Phe	1	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.734	-2.138	0.404	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131G	131	Y	G	missense	low	0.0425134343223544	0.0830887066047596	6	0.0339208224282466	-0.0239701559629874	0.108997024607696	-0.0650964799611431	-0.0245323751212295	0.0928039916293424	0.152220239860869	NA	NA	0.00641753846711495	0.0932676910591728	0.455719184810654	0.459414943731676	0.452023425889631	0.446289561061207	0.44354829401127	NA	NA	0.487051839029036	0.492634396785759	NA	NA	p.Tyr131Gly	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.734	-4.081	2.347	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131H	131	Y	H	missense	wt-like	0.872601159626267	0.101630627100932	6	0.0414905297727258	0.791281215572238	0.953921103680297	0.830778185152015	0.90300303395868	0.847826382880152	0.96299238811637	NA	NA	0.984639307482215	0.706367660168172	0.662385543049664	0.650235145344943	0.652567498013306	0.672203588086021	0.71207916924711	NA	NA	0.688277020821415	0.630521485572369	NA	NA	p.Tyr131His	1	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.734	-3.613	1.879	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131I	131	Y	I	missense	wt-like	1.03168395405739	0.149570581030922	6	0.0610619340095608	0.912004762572293	1.15136314554249	1.02727699451273	1.09254064577684	1.04551221114242	1.09977853103413	NA	NA	1.17898353615794	0.746011805720303	0.710901187652946	0.692089150016727	0.693547760462064	0.731354153772529	0.757383269488926	NA	NA	0.728254614843828	0.639437512473431	NA	NA	p.Tyr131Ile	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.734	-2.53	0.796	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131K	131	Y	K	missense	low	-0.17903659473957	0.449358384957043	6	0.183449792464315	-0.538591580940976	0.180518391461835	-0.011221346743544	0.550660235540068	-0.186304073193342	-0.137377386668122	NA	NA	-0.725563648802824	-0.564413348569659	0.355204339626803	0.470890280832794	0.576386838076655	0.362776240622145	0.347632438631461	NA	NA	0.336479594429232	0.344720959379519	NA	NA	p.Tyr131Lys	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.734	-3.509	1.775	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131L	131	Y	L	missense	wt-like	1.13256900615718	0.20438189857724	6	0.083438560695917	0.96903243227132	1.29610558004303	1.01264349656742	0.841036110828674	1.19461040453403	1.08124797529447	NA	NA	1.22638340321243	1.43949264650604	0.74462544284581	0.688972232955701	0.639169519909383	0.775966570147917	0.751245877667952	NA	NA	0.738005008023667	0.795402378046987	NA	NA	p.Tyr131Leu	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.734	-2.165	0.431	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131M	131	Y	M	missense	wt-like	0.856484824417522	0.0798645465752305	6	0.0326045646080094	0.792581052054214	0.92038859678083	0.734992674256509	0.873659997417197	0.794958776535014	0.926496143430156	NA	NA	0.946575922433395	0.862225432432862	0.660979467950644	0.629832949354278	0.646223188158505	0.656384807097544	0.699991471674497	NA	NA	0.680447189367353	0.665574128803744	NA	NA	p.Tyr131Met	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.734	-4.838	3.104	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131N	131	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr131Asn	1	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.734	-3.865	2.131	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131P	131	Y	P	missense	low	-0.0802054945202923	0.180249512859887	6	0.0735865554819931	-0.224432493011357	0.0640215039707725	-0.35689119266843	0.172558483817631	-0.0110932729485246	-3.22657706055432e-05	NA	NA	-0.104530144785674	-0.18124457476615	0.423049061699084	0.397263028874862	0.494636789264254	0.415201940734128	0.393121674544828	NA	NA	0.464229337589037	0.430896182664041	NA	NA	p.Tyr131Pro	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.734	-4.659	2.925	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131Q	131	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr131Gln	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.734	-4.551	2.817	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131R	131	Y	R	missense	low	0.105958693423359	0.112982882124175	6	0.0461250684788745	0.0155552204203217	0.196362166426397	0.216378456272821	0.238833614244157	0.0684163569292152	0.105060450223595	NA	NA	-0.072575368183836	0.0796386510542047	0.480185901421176	0.519368758894495	0.508966252491375	0.438992414872484	0.427928789056045	NA	NA	0.470802597287923	0.489569205554429	NA	NA	p.Tyr131Arg	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.734	-2.958	1.224	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131S	131	Y	S	missense	low	0.0647662455613746	0.157085045987447	6	0.0641297014818125	-0.0609256596822827	0.190458150805032	0.24262907147663	-0.0502676666122835	-0.000107753744759127	0.0109485367576102	NA	NA	-0.0941783390012974	0.279573624492348	0.456408954772282	0.524960107640841	0.446459152976293	0.418488972895081	0.396758558865581	NA	NA	0.466358756568271	0.534534876445064	NA	NA	p.Tyr131Ser	1	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.734	-3.66	1.926	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131T	131	Y	T	missense	low	0.124142107330082	0.24728005078391	6	0.100951657998349	-0.0737195065262857	0.32200372118645	0.281502203946837	0.311534601826997	0.2152900643318	0.316054369613268	NA	NA	-0.147066278904965	-0.232462316833443	0.490375011951386	0.533240037037401	0.524685061665182	0.482939231666107	0.497810792236665	NA	NA	0.455479438954582	0.419377236809018	NA	NA	p.Tyr131Thr	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.734	-4.083	2.349	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131V	131	Y	V	missense	possibly_low	0.540692918185565	0.252619622017909	6	0.103131528826439	0.33855883601519	0.742827000355939	0.900138228118077	0.81482133166451	0.46798751092524	0.405444111640903	NA	NA	0.344938218907326	0.310828107857332	0.557618679842387	0.665008749173797	0.633501576117761	0.558550098893816	0.52741702096003	NA	NA	0.556687260790959	0.54156405592617	NA	NA	p.Tyr131Val	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.734	-2.93	1.196	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131W	131	Y	W	missense	possibly_wt-like	0.820464928510436	0.203788076836187	6	0.0831961339852919	0.657403502246296	0.983526354774577	1.06571105853685	1.03815196310147	0.590426910274178	0.604124645133247	NA	NA	0.800852767398577	0.82352222661829	0.653670458778115	0.700275558374389	0.681788287136965	0.595185804131105	0.593220783047588	NA	NA	0.650471196916517	0.656869720639712	NA	NA	p.Tyr131Trp	0	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.734	-2.142	0.408	0.008344028	NA	NA	NA	NA	NA	NA	NA
Y131X	131	Y	X	nonsense	low	-0.0728210629122779	0.164995833870312	6	0.0673592671112146	-0.204842800475272	0.0592006746507159	0.0389293526348239	0.0218355335560165	-0.0392509230761835	0.0803567136535144	NA	NA	-0.349380759370441	-0.189416294871398	0.42440258328926	0.481572318107748	0.462048713475383	0.406776749368138	0.419746815838251	NA	NA	0.413862323694629	0.42905835074027	NA	NA	p.Tyr131Ter	1	11.8	18.9	13.5	0.696	5.4	-151.3	-80.7	124.1	14.1176470588235	-7.5	0	1	12.31	0	0	0	0	6	11.6529691576904	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C132A	132	C	A	missense	wt-like	1.07927900639709	0.199928214903731	6	0.08162035194994	0.919306056169724	1.23925195662446	0.894323993694738	1.06887926269278	1.18345988382646	1.4255054730158	NA	NA	0.985572910236931	0.91793251491583	0.688450479300425	0.663770324393978	0.688431890955299	0.772630167061518	0.865265294058261	NA	NA	0.68846906764555	0.678102733950365	NA	NA	p.Cys132Ala	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-1.853	-2.483	0.63	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132D	132	C	D	missense	low	0.435763480000727	0.0768155182859519	3	0.044349460160335	0.348840135352677	0.522686824648778	0.521165247849312	0.372313442219186	NA	NA	NA	NA	0.413811749933683	NA	0.570854895616154	0.584287970568308	0.537826162297982	NA	NA	NA	NA	0.570854895616154	NA	NA	NA	p.Cys132Asp	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-1.853	-4.176	2.323	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132E	132	C	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132Glu	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-1.853	-3.297	1.444	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132F	132	C	F	missense	low	0.43017747355691	0.202329251959914	6	0.0826005712234673	0.268283328856479	0.592071618257341	0.261103246121923	0.430439729387549	0.609649687859192	0.117461077679588	NA	NA	0.596676297358736	0.565734802934471	0.574643348963841	0.528895084114373	0.550393749704415	0.600937547582897	0.432035924891182	NA	NA	0.608471060952605	0.598892948223266	NA	NA	p.Cys132Phe	1	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-1.853	-3.936	2.083	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132G	132	C	G	missense	wt-like	0.861442455942259	0.145802910044705	6	0.0595237887704071	0.744777973728892	0.978106938155627	0.956942519538884	1.06724000686694	0.781756947754295	0.930774200726	NA	NA	0.690098581552872	0.741842479214562	0.664771307614447	0.677107993368908	0.68807746455244	0.652434621859986	0.701408380817754	NA	NA	0.627688498875042	0.638499824782934	NA	NA	p.Cys132Gly	1	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-1.853	-3.53	1.677	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132H	132	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132His	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-1.853	-4.186	2.333	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132I	132	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132Ile	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-1.853	-3.6	1.747	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132K	132	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132Lys	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-1.853	-3.051	1.198	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132L	132	C	L	missense	possibly_wt-like	0.738539424779954	0.155926201281624	6	0.0636566051117471	0.613774771382841	0.863304078177066	0.796021864877584	0.924179816051619	0.667685397157393	0.49354592020161	NA	NA	0.864656340171784	0.685147210219733	0.634290533455876	0.642832091881807	0.657146167543138	0.618302702511716	0.556596681131598	NA	NA	0.663595915601952	0.625748975029946	NA	NA	p.Cys132Leu	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-1.853	-2.917	1.064	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132M	132	C	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132Met	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-1.853	-4.118	2.265	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132N	132	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132Asn	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-1.853	-3.015	1.162	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132P	132	C	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132Pro	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-1.853	-4.443	2.59	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132Q	132	C	Q	missense	wt-like	1.40360897713117	0.348220914866082	3	0.20104543893539	1.00956715756176	1.79765079670059	1.29814184230114	1.12031379852403	NA	NA	NA	NA	1.79237129056836	NA	0.74978302939259	0.74978302939259	0.699552642963702	NA	NA	NA	NA	0.8544315885118	NA	NA	NA	p.Cys132Gln	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-1.853	-2.319	0.466	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132R	132	C	R	missense	wt-like	1.0025934148577	0.0962369148223047	6	0.0392885559557223	0.925589260179895	1.0795975695355	0.887274111112309	0.9116493442556	1.01123665203876	0.998828436057098	NA	NA	1.05653402102252	1.1500379246599	0.712082260237356	0.662268708076299	0.65443693206274	0.721098392254241	0.723948207100991	NA	NA	0.703066128220472	0.730303583491663	NA	NA	p.Cys132Arg	1	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-1.853	-2.95	1.097	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132S	132	C	S	missense	wt-like	0.909346134398759	0.0433423787412564	6	0.0176944520257552	0.874665645702107	0.944026623095411	0.836429908729334	0.953224373866766	0.928282553828917	0.944724105296852	NA	NA	0.886193751397829	0.907222113272859	0.671860109589667	0.651438955514472	0.663425942784343	0.696277281513736	0.706028643232944	NA	NA	0.668026270380973	0.67569394879836	NA	NA	p.Cys132Ser	1	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-1.853	-3.123	1.27	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132T	132	C	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys132Thr	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-1.853	-3.016	1.163	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132V	132	C	V	missense	possibly_low	0.62642989649796	0.231109976614926	6	0.094350252862187	0.441506798955826	0.811352994040094	0.914168781845076	0.886027423825445	0.611943582498913	0.426715352716432	NA	NA	0.356689538243361	0.563034699858535	0.599954803163453	0.667997239858031	0.648897171307095	0.601623915274286	0.534462138377611	NA	NA	0.559104566809486	0.59828569105262	NA	NA	p.Cys132Val	0	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-1.853	-2.082	0.229	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132W	132	C	W	missense	possibly_low	0.638223096222343	0.260640913048903	6	0.106406207177155	0.429670762423611	0.846775430021074	0.997049317302546	0.888888036422196	0.579161268466654	0.613222062606157	NA	NA	0.429953680829152	0.321064211707352	0.594024419014507	0.685650691955387	0.649515669418654	0.591814955084442	0.596233882944572	NA	NA	0.574175372712254	0.543866170803859	NA	NA	p.Cys132Trp	1	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-1.853	-4.361	2.508	0.007902685	NA	NA	NA	NA	NA	NA	NA
C132X	132	C	X	nonsense	low	-0.289958791084352	0.314155882026629	6	0.128253601776538	-0.541331231453909	-0.038586350714794	-0.0178183099822921	0.145015960546681	-0.392630429108785	-0.27787683322215	NA	NA	-0.719602780088023	-0.47684035465154	0.351061015227647	0.469485135778162	0.488681771569785	0.30104029942841	0.301098477845458	NA	NA	0.337705775371805	0.36441625508349	NA	NA	p.Cys132Ter	1	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C132Y	132	C	Y	missense	low	0.412136619588057	0.319599536789088	6	0.130475964527188	0.156408428266644	0.66786481090947	0.840035252294802	0.786989525203839	0.337795636079574	0.223628480616857	NA	NA	0.15439543325214	0.12997539008113	0.518543189782945	0.652206889258821	0.627484011992939	0.519594736677909	0.467198979879692	NA	NA	0.517491642887981	0.500890012524165	rs72552738	*11	p.Cys132Tyr	1	10.6	15.4	12.5	0.666	64	78.2	-100	78.7	10.8108108108108	-4.1	0	1	12.19	0	0	0	0	7	10.6468031569486	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-1.853	-3.933	2.08	0.007902685	NA	NA	0.9	0.03	NA	NA	NA
C133A	133	C	A	missense	wt-like	1.00725277783643	0.123177068572661	6	0.050286827669139	0.908692406708149	1.10581314896472	1.05083468394176	1.11526532633755	0.917217549691718	0.847056403484085	NA	NA	1.16534403631831	0.947798667245175	0.695036687576963	0.697106908885735	0.698461103858706	0.692966466268191	0.673680722172155	NA	NA	0.725448900514295	0.684819675730571	NA	NA	p.Cys133Ala	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-1.77	-2.438	0.668	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133C	133	C	C	synonymous	wt-like	0.880474273923297	0.189029512985383	6	0.0771709755234991	0.729221941245416	1.03172660660118	1.12386777651917	1.03946540527617	0.582876000870332	0.815044558025737	NA	NA	0.844641163536398	0.876950739311969	0.665982073532167	0.712662867763421	0.682072268793766	0.592926458751564	0.663078274989749	NA	NA	0.659478692202685	0.668885872074585	NA	NA	p.Cys133=	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	0	2.5	2.5	0	148	148	0	5.5	5.5	0	121	121	0	5.07	5.07	0	NA	NA	NA	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133D	133	C	D	missense	low	-0.233798213823892	0.173811052965171	6	0.0709580652367549	-0.372873466100575	-0.0947229615472085	-0.317581229935131	-0.183384142140215	-0.124890382005498	0.0320141886207973	NA	NA	-0.385596125947478	-0.423351591535826	0.404685793459991	0.405636002580097	0.417677804245246	0.381152138412036	0.403735584339886	NA	NA	0.406412639017831	0.376445956927287	NA	NA	p.Cys133Asp	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-1.77	-4.05	2.28	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133E	133	C	E	missense	low	0.0365525308394689	0.17260007494608	6	0.0704636855306717	-0.101553755018604	0.174658816697542	0.115668572454452	0.303695725079716	0.0349805728957998	0.0507440969862508	NA	NA	-0.200887801223313	-0.0848859811560922	0.448487725709261	0.497917677528953	0.522990204252315	0.428987926654318	0.409939002522521	NA	NA	0.444408078700806	0.452567372717715	NA	NA	p.Cys133Glu	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-1.77	-3.505	1.735	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133F	133	C	F	missense	low	0.549318552549455	0.152388626937165	6	0.0622123964332329	0.42738449614839	0.671252608950519	0.676182501880546	0.739857619084451	0.637708690564832	0.421911216792111	NA	NA	0.431539342532426	0.388711944442363	0.591917386765571	0.617306454983244	0.617293539168285	0.609333222160216	0.53287098995535	NA	NA	0.574501551370927	0.559080245832114	NA	NA	p.Cys133Phe	1	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-1.77	-3.72	1.95	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133G	133	C	G	missense	possibly_wt-like	0.744961932826665	0.0939364765399399	6	0.0383494059596292	0.669798478317286	0.820125387336044	0.867739202257578	0.854323216121283	0.654905812999284	0.730484617627268	NA	NA	0.663482700849489	0.698836047105089	0.631949654968746	0.658107796521014	0.642042348456984	0.614478859200158	0.63507169526948	NA	NA	0.622213477154257	0.628827614668013	NA	NA	p.Cys133Gly	1	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-1.77	-1.267	-0.503	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133H	133	C	H	missense	low	0.303303205248571	0.434298181906282	6	0.177301490314804	-0.0442013301737209	0.650807740670864	0.34834491213711	0.64031651881493	0.27221378602256	0.0919339452000973	NA	NA	-0.387816436014576	0.854826505331307	0.523724557437693	0.547477451655699	0.59577158173539	0.499971663219687	0.423581239759572	NA	NA	0.405955909970248	0.663910099168152	NA	NA	p.Cys133His	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-1.77	-5.112	3.342	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133I	133	C	I	missense	wt-like	1.01243667231851	0.102950235082374	6	0.042029257475232	0.930060841370099	1.09481250326693	0.988584674791093	1.06278484456779	1.16164077219312	1.02518619613535	NA	NA	0.848538172498948	0.987885373724788	0.690474720633048	0.683847733513186	0.687114206028077	0.766101561509798	0.732677999309933	NA	NA	0.660280326721333	0.693835235238019	NA	NA	p.Cys133Ile	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-1.77	-4.153	2.383	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133K	133	C	K	missense	low	-0.0558371367597274	0.0795003772022173	6	0.0324558930840375	-0.119449518290523	0.00777524477106872	-0.103253061807652	0.0144939546375999	-0.121565606453158	-0.00109233583501683	NA	NA	0.0304424727000874	-0.154048243800224	0.444150158205991	0.451287638736502	0.460461377706091	0.382146961138735	0.39277057523435	NA	NA	0.491993889913313	0.43701267767548	NA	NA	p.Cys133Lys	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-1.77	-4.06	2.29	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133L	133	C	L	missense	wt-like	0.950822270140257	0.113923816627256	6	0.0465092033811957	0.859665906563464	1.04197863371705	1.10496757022551	1.05322815090222	0.893409881974978	0.965460301909243	NA	NA	0.890219505779586	0.797648210050005	0.685445395640823	0.708637147072867	0.685047936379533	0.685842854902114	0.712896551852362	NA	NA	0.66885438848566	0.65105061608976	NA	NA	p.Cys133Leu	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-1.77	-3.316	1.546	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133M	133	C	M	missense	possibly_wt-like	0.799002678481427	0.315580325761725	6	0.128835128496253	0.546490466685181	1.05151489027767	1.18446117535261	1.07594675117109	0.636967706913593	0.619834959197116	NA	NA	0.923654691920989	0.353150786333164	0.642421842336938	0.72556918717627	0.689959965145517	0.609111508734825	0.59842409990409	NA	NA	0.675732175939051	0.551082488838775	NA	NA	p.Cys133Met	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-1.77	-5.022	3.252	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133N	133	C	N	missense	low	0.165534879803968	0.213952407306202	6	0.087345704523385	-0.0056595552661434	0.33672931487408	0.328073418872095	0.474386247187674	-0.116531163433793	0.12171012633332	NA	NA	0.179397569767427	0.00617308009708806	0.49784069967789	0.543159648527129	0.559895504083836	0.383653342021622	0.433443226259836	NA	NA	0.522634709240463	0.473046690115316	NA	NA	p.Cys133Asn	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-1.77	-4.132	2.362	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133P	133	C	P	missense	low	-0.236353142151861	0.329659407657094	6	0.134582889611338	-0.500130758725414	0.0274244744216913	0.0913978070738104	0.147754200011413	-0.333635582330117	-0.136385742759275	NA	NA	-0.676311246585108	-0.510938288321892	0.352354227181153	0.49274803435944	0.489273811169925	0.318692442681276	0.347960874934234	NA	NA	0.346611063492683	0.356747579428072	NA	NA	p.Cys133Pro	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-1.77	-3.603	1.833	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133Q	133	C	Q	missense	low	0.506575906038114	0.148149587961893	6	0.0604818160183687	0.388033724922534	0.625118087153694	0.681193250117401	0.451982232693208	0.245858306266367	0.534708793611735	NA	NA	0.538672797781277	0.587040055758697	0.583384715482363	0.618373738193747	0.555051492464813	0.49208570826671	0.570229984209196	NA	NA	0.59653944675553	0.603684531057734	NA	NA	p.Cys133Gln	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-1.77	-3.722	1.952	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133R	133	C	R	missense	low	0.0919260772654596	0.0722653168272025	6	0.0295021920545348	0.0341028433735876	0.149749311157332	0.0610190111684825	0.168176616132007	0.00616094042970976	0.114546272142332	NA	NA	0.176047190093497	0.0256064336267297	0.481847334117502	0.486277388201932	0.493689377897982	0.420364660240982	0.431070530009592	NA	NA	0.521945519140309	0.477417280033071	NA	NA	p.Cys133Arg	1	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-1.77	-3.648	1.878	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133S	133	C	S	missense	possibly_wt-like	0.72673581658114	0.173419058359799	6	0.0707980341092409	0.587974219550789	0.86549741361149	0.985189176710923	0.783862150204549	0.686411447863995	0.798434040327615	NA	NA	0.471545459631225	0.634972624748531	0.625356827269697	0.683124496599065	0.626807836710275	0.623905817829118	0.657576807203523	NA	NA	0.582731012665903	0.614464636634442	NA	NA	p.Cys133Ser	1	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-1.77	-3.099	1.329	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133T	133	C	T	missense	wt-like	1.03278475391802	0.100180145812075	6	0.0408983732662	0.952625415289995	1.11294409254605	1.09549106206186	1.01997005995619	0.88483265627813	0.957981129075036	NA	NA	1.16198130945252	1.07645230668441	0.708519041668947	0.706618662491489	0.677857145684013	0.683276420289936	0.710419420846405	NA	NA	0.724757170534121	0.713754069300772	NA	NA	p.Cys133Thr	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-1.77	-3.046	1.276	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133V	133	C	V	missense	wt-like	0.874367205646657	0.150325904667123	6	0.0613702935927865	0.754083640484146	0.994650770809168	0.985991206297653	1.06187987201554	0.899733656585833	0.85309906440602	NA	NA	0.627102045381506	0.818397389193394	0.679488701392134	0.683295327914426	0.686918540311154	0.687735023140951	0.675682074869842	NA	NA	0.614729791713846	0.655717137131919	NA	NA	p.Cys133Val	0	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-1.77	-3.046	1.276	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133W	133	C	W	missense	low	-0.0909099610385195	0.189984633270704	6	0.0775609017471689	-0.24292653507142	0.0611066129943812	0.106533801550021	0.138373102205623	-0.174918826459203	-0.0369711749340788	NA	NA	-0.277387753612922	-0.301088914980558	0.416307331902521	0.495971982563403	0.487245507412951	0.366182877257278	0.380887364783118	NA	NA	0.428671650301542	0.4039430135035	NA	NA	p.Cys133Trp	1	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-1.77	-5.541	3.771	0.004003016	NA	NA	NA	NA	NA	NA	NA
C133X	133	C	X	nonsense	low	-0.267662260842652	0.222626559684978	6	0.0908869124032436	-0.445797335819056	-0.0895271858662475	0.00390469324987547	-0.0597321016992503	-0.307249889842635	-0.241555140382704	NA	NA	-0.600657721652719	-0.400683404728477	0.371858721548447	0.474112108744168	0.444412830718285	0.326587437736735	0.313128363170466	NA	NA	0.362173377468871	0.381544065628024	NA	NA	p.Cys133Ter	1	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C133Y	133	C	Y	missense	low	-0.351115809176755	0.102532367105018	3	0.0591970897487319	-0.467139973073855	-0.235091645279655	-0.302076965444989	-0.282311706900828	NA	NA	NA	NA	NA	-0.468958755184447	0.396288500410418	0.408938391844002	0.396288500410418	NA	NA	NA	NA	NA	0.366188838447144	NA	NA	p.Cys133Tyr	1	12.2	15.3	9	0.868	89.4	-60.7	-159.9	-175.6	1.35135135135135	-1.6	0	0	12.11	0	0	0	0	5	10.3640198944184	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-1.77	-3.745	1.975	0.004003016	NA	NA	NA	NA	NA	NA	NA
S134A	134	S	A	missense	wt-like	0.756173735149003	0.0414685090059251	6	0.0169294479097542	0.722992626967738	0.789354843330269	0.789538402182489	0.79933061099168	0.741715871095787	0.741982114991429	NA	NA	0.687147960080683	0.777327451551952	0.639666720955167	0.641451122303352	0.630152299989379	0.640453730989522	0.638879710920811	NA	NA	0.627081541065526	0.646480447483645	NA	NA	p.Ser134Ala	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.066	-3.505	1.439	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134C	134	S	C	missense	possibly_wt-like	0.742840713953367	0.220451160777811	6	0.0899988095183154	0.566446288645988	0.919235139260745	1.00987652275337	0.96658385075507	0.639107758092307	0.594626314142622	NA	NA	0.449677748684939	0.797172089291897	0.630347689991231	0.688382870937087	0.666314418922715	0.609751844154576	0.59007489904099	NA	NA	0.57823271355835	0.650943535827888	NA	NA	p.Ser134Cys	1	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.066	-5.346	3.28	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134D	134	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser134Asp	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.066	-1.024	-1.042	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134E	134	S	E	missense	possibly_low	0.532860708551441	0.282706572630901	6	0.115414474979463	0.306652494297093	0.759068922805788	0.911964758713194	0.800991381727876	0.466598712823694	0.549511336029347	NA	NA	0.253495875863235	0.214602186151299	0.566633596623429	0.667527785642208	0.63051137816908	0.558134549665766	0.575132643581092	NA	NA	0.537877106810135	0.519922703979707	NA	NA	p.Ser134Glu	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.066	-3.324	1.258	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134F	134	S	F	missense	possibly_low	0.402738666081707	0.233578141135181	2	0.165164687533635	0.0790218269979701	0.726455505165443	0.237573978548071	0.567903353615342	NA	NA	NA	NA	NA	NA	0.55199919110697	0.523883379065556	0.580115003148385	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser134Phe	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.066	-4.611	2.545	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134G	134	S	G	missense	possibly_low	0.644572772403271	0.180264623185602	6	0.0735927242466346	0.50033368335568	0.788811861450862	0.813597848676438	0.920329043356935	0.596993738738836	0.556976024215731	NA	NA	0.489092978341906	0.490447001089781	0.591745662018828	0.646575754809952	0.656313585164659	0.597150697729524	0.577604977215598	NA	NA	0.586340626308132	0.581960610365552	NA	NA	p.Ser134Gly	1	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.066	-3.411	1.345	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134H	134	S	H	missense	possibly_wt-like	0.837548076460571	0.221081436575629	6	0.0902561185352955	0.660649334747014	1.01444681817413	1.11116343947591	0.972986831390125	0.776693407055455	0.866185026302387	NA	NA	0.45464365215398	0.843616102385572	0.66454384084038	0.709956859601384	0.667698818696257	0.65091953451485	0.680016196125604	NA	NA	0.579254225101001	0.661388862984503	NA	NA	p.Ser134His	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.066	-4.698	2.632	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134I	134	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser134Ile	1	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.066	-4.317	2.251	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134K	134	S	K	missense	wt-like	0.927470143317892	0.135624274799333	6	0.0553683783322289	0.818950115904335	1.03599017073145	0.988852672284156	1.09868226387979	0.796491225783136	0.735581640250376	NA	NA	0.952148603277542	0.993064454432348	0.682749167372319	0.683904816649533	0.694875650580044	0.65684333890384	0.63675984890059	NA	NA	0.681593518095106	0.695000018140218	NA	NA	p.Ser134Lys	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.066	-3.727	1.661	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134L	134	S	L	missense	low	0.194507354757802	0.131515444007671	6	0.0536909551857276	0.0892750162982216	0.299739693217382	0.381411556828695	0.274717086099087	0.245686405029967	0.09040987891146	NA	NA	0.0213818004220619	0.153437401255539	0.499100463167763	0.554520606298235	0.516724681438968	0.492034272837754	0.423076463102794	NA	NA	0.490130063648086	0.506166653497773	NA	NA	p.Ser134Leu	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.066	-3.997	1.931	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134M	134	S	M	missense	low	0.533028337421197	0.0772702062679711	6	0.0315454296126893	0.471200431503483	0.594856243338911	0.625338105705565	0.479046504759782	0.574906432206968	0.583576367538975	NA	NA	0.414920377138093	0.520382237177799	0.587554101559916	0.606476661143958	0.560903106620091	0.590541844240452	0.586415113934692	NA	NA	0.571082945857739	0.588693089185141	NA	NA	p.Ser134Met	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.066	-5.133	3.067	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134N	134	S	N	missense	wt-like	1.04043032645712	0.186653466873156	6	0.0762009587601191	0.891079191699868	1.18978146121438	1.23875617576633	0.955939571185228	0.812341572389963	1.13400756530805	NA	NA	0.86810653129696	1.23343054279621	0.700719796448888	0.737133955473663	0.664013000401263	0.661586000410548	0.768720058193166	NA	NA	0.664305637424112	0.749058706506625	NA	NA	p.Ser134Asn	1	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.066	-1.731	-0.335	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134P	134	S	P	missense	possibly_wt-like	0.819429064547042	0.176749937765064	6	0.0721578599321815	0.678002257878481	0.960855871215604	1.07738644014619	0.827380509267073	0.95804794071522	0.676871605816655	NA	NA	0.777172308652498	0.599715582684619	0.640908512259648	0.702762400294764	0.636217018131388	0.705183531838705	0.617314858140195	NA	NA	0.645600006387907	0.606535275788959	NA	NA	p.Ser134Pro	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.066	-4.077	2.011	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134Q	134	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser134Gln	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.066	-4.053	1.987	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134R	134	S	R	missense	possibly_wt-like	0.724372581981411	0.132015021149944	6	0.0538949067000152	0.618740505899235	0.830004658063587	0.701063181143933	0.936821919979126	0.793820526524579	0.699988896339254	NA	NA	0.541626002804553	0.67291496509702	0.623984659657319	0.622606009059499	0.659879539204224	0.656044225617315	0.624971394283515	NA	NA	0.597146936014614	0.622997925031124	NA	NA	p.Ser134Arg	1	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.066	-4.124	2.058	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134S	134	S	S	synonymous	wt-like	1.03001239549614	0.0932175598086278	6	0.0380559094330852	0.955424183608371	1.1046006073839	1.04680424766414	1.15345954273	0.915772769123539	0.932752864646521	NA	NA	1.10357194317951	1.0277130056331	0.702428125231152	0.696248430916621	0.70671914297175	0.692534166246223	0.702063721970652	NA	NA	0.712742067498235	0.702792528491652	NA	NA	p.Ser134=	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134T	134	S	T	missense	wt-like	0.851352869115182	0.0363210080252658	6	0.014827989434239	0.822290543860933	0.880415194369431	0.811218490013748	0.90298572172881	0.881152193411572	0.816144827131913	NA	NA	0.857614165313183	0.839001817091867	0.661249203951927	0.646068954341756	0.652563754905451	0.682175170582464	0.663442688378532	NA	NA	0.662147304498601	0.660351103405254	NA	NA	p.Ser134Thr	1	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.066	-2.963	0.897	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134V	134	S	V	missense	low	-0.0435786473744266	0.248473211890237	6	0.101438763980254	-0.242394971411984	0.155237676663131	0.154564978620092	0.215959965904954	-0.188188268522486	0.165817386924406	NA	NA	-0.325161299539081	-0.284464647634445	0.433448055627787	0.506202564194011	0.504020700507738	0.362212461111178	0.448051721773975	NA	NA	0.418844389481599	0.40768183578871	NA	NA	p.Ser134Val	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.066	-4.044	1.978	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134W	134	S	W	missense	low	0.565787995632681	0.0604178416733749	6	0.0246654805766717	0.517444542041032	0.614131449224329	0.603370785893039	0.649458832802665	0.527431697790413	0.581379604536413	NA	NA	0.476083895327709	0.557003157445846	0.591308362887411	0.601797649046881	0.597748257620522	0.576336691441991	0.585687537521228	NA	NA	0.583664591918589	0.596929188253594	NA	NA	p.Ser134Trp	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.066	-5.854	3.788	0.004153088	NA	NA	NA	NA	NA	NA	NA
S134X	134	S	X	nonsense	possibly_low	0.346948894707595	0.445312419089541	5	0.199149768061818	-0.0433774782230728	0.737275267638262	0.850499536751274	0.784015238070681	0.0476429770435619	0.189692243367235	NA	NA	-0.137105521694778	NA	0.457528417257761	0.654435768975461	0.626840936108709	0.432776707948734	0.455959166683766	NA	NA	0.457528417257761	NA	NA	NA	p.Ser134Ter	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S134Y	134	S	Y	missense	possibly_low	0.519945529007236	0.332306328855942	6	0.135663490665761	0.254049973285359	0.785841084729112	0.281442975936141	0.265138284463564	0.656469070909653	0.231758312507753	NA	NA	1.08803493419413	0.596829596032169	0.569556817335665	0.533227421543982	0.514653631787119	0.614946609420419	0.469891611684916	NA	NA	0.709546025908667	0.605886213127348	NA	NA	p.Ser134Tyr	0	15.5	14.7	7.3	0.599	36.7	-126.7	-80	149.4	11.1888111888112	-2.6	0	0	11.9	2	1112	0	0	6	9.0175394350571	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.066	-4.648	2.582	0.004153088	NA	NA	NA	NA	NA	NA	NA
I135A	135	I	A	missense	possibly_low	0.582067351794829	0.300641922780858	6	0.122736551017054	0.341508132214741	0.822626571374918	0.843008029860528	1.05686569287726	0.5261776086155	0.368620438118487	NA	NA	0.327008719101858	0.370723622195338	0.565498047365194	0.652840087223373	0.685834415766794	0.57596144914582	0.515220877688892	NA	NA	0.552999071699201	0.555034645584568	NA	NA	p.Ile135Ala	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.757	-2.815	1.058	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135C	135	I	C	missense	possibly_wt-like	0.814442627251417	0.191981991449097	6	0.078376319808942	0.660827863185098	0.968057391317737	0.54363252730247	0.688470926693411	0.827149538212408	0.770000062475933	NA	NA	1.00495020550402	1.05245250332026	0.6570880647878	0.589073473453816	0.606183131474752	0.666016765947782	0.648159363627819	NA	NA	0.692455075610483	0.70835647806921	NA	NA	p.Ile135Cys	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.757	-5.25	3.493	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135D	135	I	D	missense	low	0.055538151412567	0.0145008200755055	2	0.010253628208156	0.0354414094137173	0.0756348934114166	0.045284523204411	0.0657917796207229	NA	NA	NA	NA	NA	NA	0.477239266420696	0.482925961621289	0.471552571220103	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Asp	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.757	-4.408	2.651	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135E	135	I	E	missense	low	-0.0811443413661514	0.199860786675935	6	0.0815928244912135	-0.241063338765827	0.0787746560335246	0.0651679528884662	0.038121584029442	-0.0704165188508478	0.110870667046303	NA	NA	-0.408693487493867	-0.221916245816405	0.425801109564204	0.487161107684489	0.465569949267332	0.397451535536509	0.429853155367923	NA	NA	0.401661394542076	0.421749063760485	NA	NA	p.Ile135Glu	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.757	-3.716	1.959	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135F	135	I	F	missense	low	-0.255699051731003	0.920344283047013	4	0.460172141523506	-1.15761987580574	0.646221772343738	NA	1.08100211670411	-0.3760301078139	NA	NA	NA	-0.869929608145054	-0.857838607669171	0.306395074316478	NA	0.691052994673168	0.306007364613617	NA	NA	NA	0.306782784019339	0.278729185130228	NA	NA	p.Ile135Phe	1	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.757	-1.721	-0.036	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135G	135	I	G	missense	low	-0.00550873494631469	0.128465793556345	6	0.0524459406024613	-0.108300889662466	0.0972834197698363	0.143348610946937	0.0955404302396728	-0.0527304640478153	0.0775829335386218	NA	NA	-0.138919342632365	-0.157874577722939	0.446653717305212	0.503813491677389	0.47798457961235	0.402743468476558	0.418828129122672	NA	NA	0.457155305086814	0.436152129523609	NA	NA	p.Ile135Gly	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.757	-3.584	1.827	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135H	135	I	H	missense	low	0.509825921805737	0.25854807379987	6	0.105551809131522	0.302948177404908	0.716703666206565	0.909376043039496	0.758503267429446	0.368660482833322	0.369664372908868	NA	NA	0.272182098588909	0.380569266034379	0.549484951537734	0.666976392388206	0.621324947791489	0.528829961890358	0.515566632934127	NA	NA	0.541720957646508	0.557248945428961	NA	NA	p.Ile135His	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.757	-5.106	3.349	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135K	135	I	K	missense	low	0.303073687204388	0.126698975737914	6	0.051724640248526	0.201695255203986	0.40445211920479	0.152086552693863	0.299440812893215	0.220396035301092	0.526683084574178	NA	NA	0.29375615577823	0.326079481985749	0.533532177328852	0.505674662520548	0.522070242159163	0.484467014784742	0.567571838296216	NA	NA	0.546158850686131	0.544994112498541	NA	NA	p.Ile135Lys	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.757	-4.266	2.509	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135L	135	I	L	missense	wt-like	1.14824499799617	0.0552985695633683	6	0.0225755464893421	1.10399773994575	1.19249225604659	1.10104694283056	1.09303928091464	1.17879991121339	1.16419819887392	NA	NA	1.23645915983269	1.11592649431184	0.731354757351271	0.707802058260684	0.693655571247572	0.771235833342355	0.778719312944097	NA	NA	0.740077642289053	0.722631872413489	NA	NA	p.Ile135Leu	1	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.757	-1.98	0.223	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135M	135	I	M	missense	wt-like	0.988028572971489	0.224755142909367	6	0.0917559028657103	0.808190307985741	1.16786683795724	1.16528408101335	1.26486042005756	0.866199013757409	0.650238355771266	NA	NA	1.07899628148085	0.902593285748505	0.692693842033894	0.721484489672617	0.73080532378891	0.677700954888144	0.608493822587295	NA	NA	0.707686729179644	0.674652918649955	NA	NA	p.Ile135Met	1	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.757	-3.353	1.596	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135N	135	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Asn	1	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.757	-4.561	2.804	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135P	135	I	P	missense	low	0.495288594038513	0.185423455554286	6	0.0756988087419395	0.346921655231726	0.643655532845301	0.591973697660052	0.6503109980614	0.319185134955748	0.590074991776077	NA	NA	0.615051894431003	0.2051348473468	0.593249994613579	0.599370083273327	0.597932505779067	0.514026195529258	0.588567483448091	NA	NA	0.612251014515827	0.517793485496454	NA	NA	p.Ile135Pro	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.757	-3.845	2.088	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135Q	135	I	Q	missense	low	0.217125853381016	0.224325795152049	5	0.100321545413335	0.0204992374974799	0.413752469264551	0.246424128217969	0.179084149879497	0.146939335048056	NA	NA	NA	0.565574300342727	-0.0523926465831711	0.496047715071027	0.525768450058275	0.496047715071027	0.462487668001892	NA	NA	NA	0.602073222341884	0.459875171665643	NA	NA	p.Ile135Gln	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.757	-4.662	2.905	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135R	135	I	R	missense	low	0.0330668810477529	0.0644443703888934	6	0.0263093040412857	-0.0184984073314813	0.084632169426987	0.00214051766187326	0.0640251664914162	-0.0342980851697555	-0.0366664121677809	NA	NA	0.0963006296107896	0.106899469859975	0.472453475091704	0.473736341514115	0.471170608669293	0.408258712776917	0.380988303391517	NA	NA	0.505541246981649	0.495700203976317	NA	NA	p.Ile135Arg	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.757	-4.551	2.794	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135S	135	I	S	missense	low	-0.0406407397451797	0.240566459234697	6	0.0982108457255095	-0.233130460258398	0.151848980768038	0.0996222559259192	0.298487043647476	0.00401557274992425	-0.0146644024477643	NA	NA	-0.296314633333166	-0.334990275013468	0.42225051457227	0.494499831847674	0.521864026022793	0.419722734044348	0.388275454214071	NA	NA	0.424778295100192	0.396318547549542	NA	NA	p.Ile135Ser	1	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.757	-4.049	2.292	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135T	135	I	T	missense	low	0.316133984182823	0.297075135122318	3	0.171516409232415	-0.0200320006703427	0.652299969035989	0.393818497476296	0.566648727112235	NA	-0.0120652720400606	NA	NA	NA	NA	0.557163269393837	0.557163269393837	0.579843738132015	NA	0.389136296270294	NA	NA	NA	NA	NA	NA	p.Ile135Thr	1	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.757	-3.526	1.769	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135V	135	I	V	missense	possibly_wt-like	0.850594502081802	0.202795021782957	6	0.0827907209574739	0.688327670751047	1.01286133341256	1.02419546882522	1.07577168361149	0.857200796928192	0.906190004970958	NA	NA	0.707857840068205	0.532351218086737	0.682465333445858	0.691432788836012	0.689922113478665	0.675008553413052	0.693265999980826	NA	NA	0.631341668469544	0.591384930673364	NA	NA	p.Ile135Val	1	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.757	-2.303	0.546	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135W	135	I	W	missense	possibly_wt-like	0.826942689729202	0.145584607940744	6	0.0594346673096606	0.710452882369147	0.943432497089257	0.872602759613648	1.08979993206469	0.823260983894455	0.77343305540846	NA	NA	0.688310307485794	0.71424909990816	0.654220056218195	0.659143728254976	0.692955185900512	0.664853252156068	0.649296384181415	NA	NA	0.627320641824994	0.632294033013162	NA	NA	p.Ile135Trp	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.757	-5.365	3.608	0.007432872	NA	NA	NA	NA	NA	NA	NA
I135X	135	I	X	nonsense	low	-0.154418355312044	0.487532881380021	6	0.199034465368315	-0.544518739116125	0.235682028492038	0.505410851279245	0.0597232251336316	0.0192018284275793	-0.113324737324961	NA	NA	-0.902182174169607	-0.495339125218149	0.392261271918254	0.580932303479077	0.470240478315798	0.424266689581725	0.355598769238348	NA	NA	0.300148267525093	0.360255854254783	NA	NA	p.Ile135Ter	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I135Y	135	I	Y	missense	wt-like	1.20421510987011	0.0410323797557404	6	0.016751398888945	1.17138297135711	1.2370472483831	1.21206212601902	1.17882661196746	1.27267625087546	1.20898957780903	NA	NA	1.20330768417414	1.14942840837554	0.732353185618346	0.731448155715041	0.712203801900049	0.799325042591198	0.79355439110304	NA	NA	0.733258215521651	0.73016650237887	NA	NA	p.Ile135Tyr	0	18.5	17	8.1	0.858	113.1	62.2	-56.8	-30.9	3.1413612565445	-1.8	0	0	12.03	0	0	0	0	5	8.78346479622058	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.757	-2.543	0.786	0.007432872	NA	NA	NA	NA	NA	NA	NA
F136A	136	F	A	missense	low	0.405994742258267	0.319532770540925	6	0.130448707320515	0.150319974080252	0.661669510436282	0.745452784486191	0.812658387065541	0.0408708581472531	0.126531296980509	NA	NA	0.436863933762507	0.2735911931076	0.554393132797465	0.632060939965747	0.633033922038565	0.430750388373203	0.435040016648278	NA	NA	0.575596846806155	0.533189418788775	NA	NA	p.Phe136Ala	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-0.961	-3.602	2.641	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136C	136	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe136Cys	1	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-0.961	-5.207	4.246	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136D	136	F	D	missense	possibly_wt-like	0.768807853226298	0.208293414835177	6	0.0850354305213411	0.602141471994611	0.935474234457984	1.01541282474483	0.93687340203291	0.571501067815178	0.562436898662679	NA	NA	0.915448463117629	0.611174462984566	0.63450153256341	0.689562096450814	0.659890670230173	0.589522908123919	0.579413639979787	NA	NA	0.674044113032366	0.609112394896647	NA	NA	p.Phe136Asp	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-0.961	-4.28	3.319	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136E	136	F	E	missense	low	0.520788771670085	0.0424278178724658	6	0.0173210841145463	0.486840070632385	0.554737472707784	0.483220106219229	0.577795216574753	0.570652702035182	0.494443658184159	NA	NA	0.510181262857847	0.488439684149337	0.581881451081642	0.57620570207913	0.582253740343052	0.589269064354556	0.556894015427929	NA	NA	0.590678593443828	0.581509161820232	NA	NA	p.Phe136Glu	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-0.961	-4.184	3.223	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136G	136	F	G	missense	low	0.555524932706254	0.141875675139991	6	0.0579205018343079	0.442002835144524	0.669047030267983	0.668379790473748	0.754511872987195	0.55328371211029	0.528173902655259	NA	NA	0.352247084909095	0.476553233101937	0.581453941701373	0.615644487052063	0.620461961336131	0.584072001982955	0.568065603017897	NA	NA	0.558190731615763	0.578835881419791	NA	NA	p.Phe136Gly	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-0.961	-3.287	2.326	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136H	136	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe136His	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-0.961	-4.745	3.784	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136I	136	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe136Ile	1	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-0.961	-3.674	2.713	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136K	136	F	K	missense	possibly_low	0.678209642560045	0.324910675191038	5	0.145304471268503	0.393418112081144	0.963001173038947	0.605123620371732	1.17791189804406	NA	0.324183278130148	NA	NA	0.782012112447909	0.501817303806375	0.602171000634602	0.602171000634602	0.712006029984032	NA	0.500503118216839	NA	NA	0.64659557858781	0.584517808243889	NA	NA	p.Phe136Lys	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-0.961	-4.169	3.208	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136L	136	F	L	missense	wt-like	0.867386949287675	0.0758674657603357	6	0.0309727631984827	0.806681448916961	0.928092449658389	0.76557670153522	0.882578204159703	0.879605832691559	0.792734717782826	NA	NA	0.915906350696386	0.967919888860357	0.664913736168381	0.636347309541852	0.648151409419575	0.681712476255065	0.655689169505932	NA	NA	0.67413830283083	0.689344968196952	NA	NA	p.Phe136Leu	1	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-0.961	-2.435	1.474	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136M	136	F	M	missense	possibly_low	0.588333015489691	0.197286588579399	6	0.0805419125189873	0.4304737677065	0.746192263272882	0.804557670452812	0.810390318208545	0.507359781131981	0.648745419011905	NA	NA	0.356066790644829	0.402878113488075	0.589165114495502	0.644650207969051	0.632543538857517	0.570330872839842	0.607999356151163	NA	NA	0.558976464468386	0.562266238178209	NA	NA	p.Phe136Met	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-0.961	-3.408	2.447	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136N	136	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe136Asn	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-0.961	-4.417	3.456	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136P	136	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe136Pro	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-0.961	-3.578	2.617	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136Q	136	F	Q	missense	possibly_low	0.598662060661293	0.362819959104991	6	0.148120628050781	0.308350964314308	0.888973157008278	0.711237993094057	0.914748905824939	0.487492134095836	-0.0671813438825511	NA	NA	0.893723923444994	0.651950751390483	0.621528136943212	0.624773231488381	0.655107093754496	0.564386174773328	0.370881639837817	NA	NA	0.669575264982314	0.618283042398043	NA	NA	p.Phe136Gln	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-0.961	-4.553	3.592	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136R	136	F	R	missense	possibly_low	0.551199695761792	0.232969634243961	6	0.0951094549100886	0.364788589548782	0.737610801974802	0.717880452129544	0.933846220407466	0.415161619841449	0.413817938206358	NA	NA	0.309008623073332	0.517483320912601	0.568668739620324	0.626188067091751	0.659236157934166	0.542743799737386	0.530190464746343	NA	NA	0.549296360606126	0.588041118634522	NA	NA	p.Phe136Arg	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-0.961	-4.438	3.477	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136S	136	F	S	missense	possibly_low	0.601230613050071	0.287493470787801	6	0.117368717968642	0.371192152919893	0.831269073180249	0.601052432641714	1.07819494709834	0.751769727098105	0.510339840744152	NA	NA	0.258975099039871	0.407051631678247	0.582254355620493	0.60130384265626	0.690446051565257	0.643461995542907	0.562158892650128	NA	NA	0.539004210821437	0.563204868584727	NA	NA	p.Phe136Ser	1	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-0.961	-3.953	2.992	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136T	136	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe136Thr	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-0.961	-3.961	3	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136V	136	F	V	missense	low	0.596828089118292	0.0843047781518074	6	0.0344172815584106	0.529371456818032	0.664284721418551	0.505582443174711	0.695426056807575	0.580743921781211	0.536493647186841	NA	NA	0.706211515450346	0.556510950309065	0.594553499421009	0.580968852341729	0.607686912464233	0.592288508700625	0.570821134625158	NA	NA	0.631003011141511	0.596818490141394	NA	NA	p.Phe136Val	1	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-0.961	-2.969	2.008	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136W	136	F	W	missense	wt-like	0.977699099774844	0.133317925328486	6	0.0544268151035433	0.871024502378678	1.08437369717101	1.18039478625239	0.972829352351655	0.943636068056179	0.936861627083713	NA	NA	1.05294002133234	0.779532743572783	0.701599053782636	0.724703051300172	0.667664769874682	0.700871283318527	0.703424560001126	NA	NA	0.702326824246745	0.646976420917013	NA	NA	p.Phe136Trp	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-0.961	-4.875	3.914	0.002579608	NA	NA	NA	NA	NA	NA	NA
F136X	136	F	X	nonsense	low	-0.46721051094349	0.102798671440004	6	0.041967381877338	-0.549465067948512	-0.384955953938469	-0.537382318489546	-0.373138632764615	-0.403162154818302	-0.370185491354804	NA	NA	-0.624661066883836	-0.49473340134984	0.358027204328534	0.35881864110524	0.376650650046012	0.297889049089177	0.270525492804541	NA	NA	0.357235767551827	0.360392082447603	NA	NA	p.Phe136Ter	0	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F136Y	136	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe136Tyr	1	18.6	17.4	4.2	0.605	94.1	61.9	-75.5	-10	24.5614035087719	-0.8	0	0	14.07	0	0	0	0	5	11.9630901757748	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-0.961	-2.096	1.135	0.002579608	NA	NA	NA	NA	NA	NA	NA
D137A	137	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Ala	1	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.051	-2.077	0.026	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137C	137	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Cys	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.051	-4.4	2.349	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137E	137	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Glu	1	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.051	-2.455	0.404	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137F	137	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Phe	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.051	-4.089	2.038	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137G	137	D	G	missense	possibly_low	0.688754669741908	0.20323638839578	6	0.0829709081226268	0.526134678056977	0.851374661426838	0.867002134092361	0.945539839187178	0.636546287703532	0.73966846231356	NA	NA	0.403212177197167	0.540559117957647	0.623549416989436	0.657950801908524	0.661764455943049	0.608985413784644	0.638113420194228	NA	NA	0.568674509717592	0.593230899479881	NA	NA	p.Asp137Gly	1	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.051	-3.022	0.971	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137H	137	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137His	1	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.051	-2.933	0.882	0.008051812	NA	NA	NA	NA	4.06e-06	NA	NA
D137I	137	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Ile	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.051	-4.37	2.319	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137K	137	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Lys	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.051	-2.641	0.59	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137L	137	D	L	missense	possibly_wt-like	0.751393316328643	0.147907674355635	6	0.0603830552021737	0.633044702855888	0.869741929801397	0.923415788534645	0.906110463495747	0.772783280536918	0.561515234591804	NA	NA	0.730668287508715	0.613866843304027	0.642891729627436	0.669966840907749	0.653239360852288	0.649749565997074	0.579108381270349	NA	NA	0.636033893257798	0.609717915207953	NA	NA	p.Asp137Leu	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.051	-3.006	0.955	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137M	137	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Met	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.051	-4.299	2.248	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137N	137	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Asn	1	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.051	-2.748	0.697	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137P	137	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Pro	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.051	-4.368	2.317	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137Q	137	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Gln	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.051	-2.746	0.695	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137R	137	D	R	missense	possibly_low	0.657042839984532	0.206762354102986	6	0.0844103775948279	0.491601539977243	0.822484139991822	0.813165428140809	0.997291159007733	0.62281302580949	0.474380854682515	NA	NA	0.514236743592226	0.520369828674421	0.598194521098305	0.646483649767803	0.672953700378347	0.604876215786516	0.550249137214521	NA	NA	0.591512826410093	0.5886902984944	NA	NA	p.Asp137Arg	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.051	-3.488	1.437	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137S	137	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Ser	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.051	-2.599	0.548	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137T	137	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Thr	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.051	-2.575	0.524	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137V	137	D	V	missense	possibly_low	0.713906945149677	0.272073005069399	4	0.1360365025347	0.447280299598874	0.98053359070048	0.427556240861616	0.691651803379142	NA	NA	NA	NA	1.08263976228217	0.653779974075781	0.612782655866998	0.56434936723259	0.606870874451716	NA	NA	NA	NA	0.708436211669019	0.618694437282281	NA	NA	p.Asp137Val	1	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.051	-3.52	1.469	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137W	137	D	W	missense	possibly_low	0.409868908558075	0.469899021010907	6	0.191835472018346	0.0338782924448762	0.785859524671274	1.05718412465021	0.933834028606964	0.150116001747017	0.315765266524391	NA	NA	0.00621278701227547	-0.0038987571924037	0.492362380394926	0.6984593319459	0.659233521923405	0.463438174337591	0.497715040174071	NA	NA	0.487009720615781	0.470781519029761	NA	NA	p.Asp137Trp	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.051	-5.903	3.852	0.008051812	NA	NA	NA	NA	NA	NA	NA
D137X	137	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Ter	0	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D137Y	137	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp137Tyr	1	15.2	19	4.2	0.656	82.6	85.4	-78.5	-21	15.5080213903743	-3.9	0	0	14.84	1	3	0	0	7	13.7277038803453	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.051	-4.684	2.633	0.008051812	NA	NA	NA	NA	4.88e-05	NA	NA
L138A	138	L	A	missense	wt-like	1.01737306580065	0.14492241929853	3	0.0836709977936182	0.85338092357463	1.18136520802667	0.998739452286372	0.882668697201912	NA	NA	NA	NA	NA	1.17071104791367	0.686010688627831	0.686010688627831	0.648170975080363	NA	NA	NA	NA	NA	0.734952999451889	NA	NA	p.Leu138Ala	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.253	-2.53	1.277	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138C	138	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138Cys	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.253	-3.96	2.707	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138D	138	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138Asp	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.253	-4.406	3.153	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138E	138	L	E	missense	possibly_low	0.617585433285066	0.270331097206285	6	0.110362208293686	0.401279479775133	0.833891386794999	0.425966628681932	0.225220583003573	0.956958021611089	0.593607012005528	NA	NA	0.858902823609174	0.6448575307991	0.603212534417061	0.564010781793771	0.506022954917818	0.704857411690748	0.589737302225913	NA	NA	0.662412388049277	0.616687766608209	NA	NA	p.Leu138Glu	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.253	-4.212	2.959	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138F	138	L	F	missense	possibly_low	0.715537865564433	0.379530677217863	6	0.154942750152785	0.411855655599388	1.01922007552948	1.20660608491707	1.14812976945855	0.37256949727802	0.357825007212628	NA	NA	0.707702501918437	0.500394332601887	0.607753747270863	0.730286025672049	0.705566783261394	0.529999597658957	0.511645389167319	NA	NA	0.631309714623886	0.584197779917841	NA	NA	p.Leu138Phe	1	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.253	-1.965	0.712	0.005457095	0.897763578	0.208353332606064	NA	NA	3.61e-05	NA	NA
L138G	138	L	G	missense	low	0.0354347911249571	0.090436049702828	6	0.0369203626874845	-0.0369277900386689	0.107797372288583	0.0989678387169519	0.169408114215943	0.0335430257756458	0.0148190482959918	NA	NA	-0.0122701215011034	-0.0918591587536863	0.467103393659552	0.494360441787192	0.493955642277916	0.428557790988521	0.398040487275737	NA	NA	0.483207692544579	0.450999094774525	NA	NA	p.Leu138Gly	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.253	-4.048	2.795	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138H	138	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138His	1	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.253	-5.168	3.915	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138I	138	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138Ile	1	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.253	-2.671	1.418	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138K	138	L	K	missense	low	0.0995718067078198	0.0916772176861072	6	0.0374270673948367	0.0262161025669865	0.172927510848653	-0.0552819681074195	0.224276382473687	0.090903764795624	0.146609196996706	NA	NA	0.0862096523159734	0.104713811772348	0.478357034463389	0.461505422683246	0.505818807650435	0.445720984683552	0.441689894885768	NA	NA	0.50346548174627	0.495208646243532	NA	NA	p.Leu138Lys	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.253	-4.139	2.886	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138M	138	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138Met	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.253	-3.163	1.91	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138N	138	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138Asn	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.253	-4.505	3.252	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138P	138	L	P	missense	low	-0.280280451063512	0.667685173525494	4	0.333842586762747	-0.934599897624185	0.37403899549716	NA	0.622396812319767	-0.325780933470264	-0.432157873042851	NA	NA	NA	-0.985579810060701	0.285521335731521	NA	0.591897130284134	0.321042671463042	0.25	NA	NA	NA	0.25	NA	NA	p.Leu138Pro	1	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.253	-4.493	3.24	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138Q	138	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138Gln	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.253	-3.767	2.514	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138R	138	L	R	missense	low	-0.0831218692408911	0.179714555411101	6	0.0733681600180553	-0.226920820488251	0.0606770820064688	-0.0406333557826692	0.224683186274235	-0.167651653342973	-0.0515559413385044	NA	NA	-0.311137875281566	-0.152435575973869	0.429552224032054	0.464625559088499	0.505906763420014	0.368357324482683	0.376056833670132	NA	NA	0.421729079012083	0.437375369052025	NA	NA	p.Leu138Arg	1	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.253	-4.415	3.162	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138S	138	L	S	missense	low	0.492931187454596	0.268393111845777	6	0.109571029083315	0.278175916702308	0.707686458206885	0.582916700664957	0.942783564927114	0.458063001011295	0.501681963145268	NA	NA	0.145343261320983	0.326798633657962	0.557435953346097	0.597440954054792	0.661168517007897	0.555580536630645	0.559291370061549	NA	NA	0.51562956518724	0.545155850772026	NA	NA	p.Leu138Ser	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.253	-3.949	2.696	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138T	138	L	T	missense	low	0.443012691940154	0.249068967525197	6	0.101681980199761	0.243719672871907	0.642305711008401	0.774522370744676	0.709934637661093	0.329853521089885	0.437763578250283	NA	NA	0.180786093808632	0.225215950086357	0.530520844570309	0.638252726078995	0.610823838404329	0.517218336717847	0.538121353458928	NA	NA	0.52292033568169	0.522309755168439	NA	NA	p.Leu138Thr	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.253	-3.379	2.126	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138V	138	L	V	missense	wt-like	1.14954997185347	0.060631653211794	6	0.0247527687717127	1.10103543654326	1.19806450716367	1.03571273224743	1.16319627766682	1.13455439369588	1.20624766577441	NA	NA	1.18534729224537	1.17224146949089	0.732430432644435	0.693885951777037	0.708824339662144	0.757996910687864	0.792646259219058	NA	NA	0.729563671763369	0.735297193525501	NA	NA	p.Leu138Val	1	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.253	-2.229	0.976	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138W	138	L	W	missense	possibly_low	0.603595650432042	0.227634694630527	6	0.0929314749331761	0.42145330653283	0.785737994331254	0.88698753544094	0.874879262604776	0.52200246190874	0.391929976045851	NA	NA	0.374011457038322	0.571763209553623	0.587480464194668	0.662207667810827	0.646486807642271	0.574712182611644	0.522941086917151	NA	NA	0.562667773404263	0.600248745777692	NA	NA	p.Leu138Trp	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.253	-5.389	4.136	0.005457095	NA	NA	NA	NA	NA	NA	NA
L138X	138	L	X	nonsense	low	-0.115988423657286	0.134500271447979	6	0.054909505885563	-0.22360907760188	-0.00836776971269278	-0.322034469438826	-0.159837048514719	-0.0618077839775902	0.0692660365026485	NA	NA	-0.0445601406239799	-0.176957135891252	0.419421251821458	0.404687468043941	0.422768963025932	0.400027398166999	0.416073540616984	NA	NA	0.476565471757955	0.431860434000849	NA	NA	p.Leu138Ter	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L138Y	138	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu138Tyr	0	16.3	21.9	6.4	0.791	73.5	64.5	-63.9	-35.3	0.523560209424084	-4.3	0	0	14.89	0	0	0	0	7	14.0634406500456	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.253	-3.542	2.289	0.005457095	NA	NA	NA	NA	NA	NA	NA
P139A	139	P	A	missense	wt-like	0.964858715143949	0.184540303856049	6	0.0753382635709137	0.817198431887173	1.11251899840073	0.938631613373486	1.02976414335305	1.1973057944493	1.02075380907899	NA	NA	0.966799263805641	0.635897666803232	0.682290987547871	0.67320779288075	0.679974741786434	0.776773071249366	0.731209975552347	NA	NA	0.684607233309308	0.614672679959111	NA	NA	p.Pro139Ala	1	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.411	-2.878	0.467	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139C	139	P	C	missense	low	0.36914305290894	0.390963535787078	6	0.159610195118782	0.0563128189107173	0.681973286907164	0.647030437511132	1.00758633529942	-0.0369001335306996	0.206416250965855	NA	NA	0.313008185770377	0.0777172414375616	0.519628084320752	0.611097101133828	0.67517963866227	0.407480140868923	0.461498222764529	NA	NA	0.55011909094836	0.489137077693143	NA	NA	p.Pro139Cys	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.411	-4.151	1.74	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139D	139	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro139Asp	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.411	-2.362	-0.049	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139E	139	P	E	missense	wt-like	0.968241139712186	0.0907820842806073	6	0.0370616307123042	0.895601678307746	1.04088060111663	1.01693907118867	1.0306415864306	0.84181605517814	0.862942991144448	NA	NA	1.04580827592907	1.01129885840218	0.685025820186383	0.689887185065848	0.680164455306917	0.670405207864938	0.67894242152644	NA	NA	0.700859788027837	0.699100962530761	NA	NA	p.Pro139Glu	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.411	-2.989	0.578	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139F	139	P	F	missense	wt-like	1.06287283140027	0.151631263577247	6	0.0619032041362864	0.94154478076552	1.18420088203502	1.06299325748954	0.986457406211652	0.825020303262028	1.15552693835623	NA	NA	1.27219081643741	1.07504826664477	0.706567484358133	0.699696670094601	0.670611315515366	0.665379666905825	0.775847357880984	NA	NA	0.74742782537	0.713438298621665	NA	NA	p.Pro139Phe	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.411	-4.137	1.726	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139G	139	P	G	missense	wt-like	0.978379205640691	0.0540811828108528	6	0.0220785504287943	0.935106041969403	1.02165236931198	0.927331142912633	1.00591385400567	1.04060653994949	0.961392567628876	NA	NA	0.908936619198455	1.02609451014902	0.688623277494236	0.670800806573806	0.674818028522198	0.729886303352068	0.711549302506311	NA	NA	0.672704593694376	0.702428526466275	NA	NA	p.Pro139Gly	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.411	-2.765	0.354	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139H	139	P	H	missense	possibly_wt-like	0.928704044694958	0.893834107192719	6	0.364906246219721	0.2135009443706	1.64390714501932	-0.198268134722135	-0.206147824688414	1.27509831398715	1.33551156856713	NA	NA	1.7645323207219	1.60149802430412	0.8159436935285	0.431049545088045	0.412756028159873	0.800049760212308	0.835458964401417	NA	NA	0.848704971147819	0.831837626844692	NA	NA	p.Pro139His	1	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.411	-3.332	0.921	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139I	139	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro139Ile	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.411	-3.753	1.342	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139K	139	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro139Lys	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.411	-3.143	0.732	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139L	139	P	L	missense	wt-like	0.964177376786374	0.198040075247389	6	0.0808495221630813	0.805715225179462	1.12263952839329	1.02544100261233	1.12817629439272	1.03651114386445	1.15720777361487	NA	NA	0.682806504774747	0.754921541459123	0.696475346554542	0.691698086000478	0.701252607108605	0.728660899400406	0.776404057027718	NA	NA	0.626188481678737	0.641441325203465	NA	NA	p.Pro139Leu	1	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.411	-3.513	1.102	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139M	139	P	M	missense	possibly_low	0.645593431195478	0.403080134880702	6	0.16455677598499	0.323068076852872	0.968118785538084	1.30987551548086	0.846233747159459	0.745969754866822	0.405055331636118	NA	NA	0.271641887904142	0.294784350125462	0.590951571812685	0.752282287345751	0.640293310057974	0.641726556834618	0.527288255516886	NA	NA	0.541609833567397	0.537955791110792	NA	NA	p.Pro139Met	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.411	-5.198	2.787	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139N	139	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro139Asn	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.411	-2.553	0.142	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139P	139	P	P	synonymous	possibly_wt-like	0.805838734336257	0.257235560915704	6	0.105015977990349	0.600011199673922	1.01166626899859	0.603871138025045	1.26192423175405	0.813841378887773	0.549270579731382	NA	NA	0.892893221995137	0.71323185562415	0.647050009143562	0.601904223435493	0.730170485320058	0.662034765016213	0.575052904162872	NA	NA	0.669404385478752	0.632065253270911	NA	NA	p.Pro139=	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139Q	139	P	Q	missense	wt-like	1.18373229797626	0.161553044194855	6	0.0659537541117827	1.05446531527195	1.31299928068056	1.01578763337731	1.17990341057927	1.21388827683191	1.47134095359265	NA	NA	1.04752267693913	1.17395083653727	0.724059125566424	0.689641930228464	0.712436618433365	0.781734798764382	0.880446182724257	NA	NA	0.701212449015192	0.735681632699484	NA	NA	p.Pro139Gln	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.411	-3.11	0.699	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139R	139	P	R	missense	wt-like	1.02268017317567	0.0639701082224856	6	0.026115687322618	0.971494366591834	1.07386597975952	0.914873358917714	1.07782428365359	1.05403864409092	1.0839548169064	NA	NA	1.01411729400025	0.99127264148518	0.694468914496572	0.668147313907771	0.690365909765957	0.73390539043236	0.75214239409213	NA	NA	0.694340792231794	0.69459703676135	NA	NA	p.Pro139Arg	1	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.411	-2.844	0.433	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139S	139	P	S	missense	possibly_low	0.707847514868883	0.198751410549111	6	0.081139923583956	0.548816186935997	0.866878842801769	0.795950383794879	0.899619143393056	0.618765049769734	0.939477314895121	NA	NA	0.463742899635556	0.529530297724954	0.623240933561483	0.642816866499123	0.651835861046127	0.603665000623842	0.704290885933575	NA	NA	0.581125986481345	0.590750501516647	NA	NA	p.Pro139Ser	1	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.411	-2.151	-0.26	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139T	139	P	T	missense	wt-like	1.27660238163365	0.106602971384862	6	0.043520480826238	1.19130380662436	1.36190095664294	1.19685304228084	1.10206954956357	1.29372836736914	1.33416623807369	NA	NA	1.35487245357834	1.37792463893631	0.772995749940528	0.728208639588189	0.695608021611727	0.805624151689942	0.835013385732167	NA	NA	0.76443585769106	0.781555642189996	NA	NA	p.Pro139Thr	1	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.411	-2.161	-0.25	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139V	139	P	V	missense	wt-like	0.943231592321395	0.122411507636317	6	0.0499742887256305	0.845283786266154	1.04117939837664	1.17450389790555	0.972435664193248	0.899872976270815	0.893061830215699	NA	NA	0.826214061147424	0.893301124195636	0.680169903735143	0.723448299328943	0.667579649861299	0.687776709680903	0.688917897662729	NA	NA	0.655688143734456	0.672563097789383	NA	NA	p.Pro139Val	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.411	-3.431	1.02	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139W	139	P	W	missense	wt-like	0.96301190640505	0.100481235056199	6	0.0410212924353909	0.882611650632399	1.0434121621777	0.980639490444871	0.94469758663757	0.907962386994948	0.807026593721014	NA	NA	1.07441202527554	1.06333335535636	0.686176300877876	0.68215541902117	0.661582351028885	0.690197182734582	0.660422694162276	NA	NA	0.706743724415781	0.710803597766436	NA	NA	p.Pro139Trp	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.411	-5.94	3.529	0.008308914	NA	NA	NA	NA	NA	NA	NA
P139X	139	P	X	nonsense	low	0.102217021586261	0.210000952596079	6	0.0857325298931321	-0.0658156493077811	0.270249692480304	0.212228981469427	0.068529518393796	-0.0378621216242854	-0.209308084618294	NA	NA	0.189415388450871	0.390298447446053	0.495314714215321	0.518484925865829	0.472144502564813	0.407192299598664	0.323808712917097	NA	NA	0.524695425378245	0.559437052701389	NA	NA	p.Pro139Ter	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P139Y	139	P	Y	missense	possibly_low	0.641241810899157	0.324331385664456	6	0.13240773374129	0.381727421491659	0.900756200306655	1.03259288668658	0.929366195580715	0.411491774303361	0.206736462851991	NA	NA	0.478571928223549	0.78869161774875	0.616606329080098	0.693221428510437	0.658267523838716	0.541645726893884	0.461604278181245	NA	NA	0.584176392910582	0.649036265249614	NA	NA	p.Pro139Tyr	0	17.7	24.2	3.7	0.702	100.9	55.3	-59	-19.3	48.7012987012987	-0.4	0	0	15.66	0	0	0	0	5	17.1635835209606	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.411	-4.759	2.348	0.008308914	NA	NA	NA	NA	NA	NA	NA
R140A	140	R	A	missense	possibly_wt-like	0.793089166316275	0.221943963442211	6	0.0906082436540566	0.615500272051894	0.970678060580656	0.920808431060392	1.11119018338514	0.446477393715952	0.722798095132423	NA	NA	0.738031911670796	0.819228982932944	0.646726395953251	0.669411476973161	0.697580009989769	0.552113949109601	0.632525889252954	NA	NA	0.637548628114043	0.655904163792459	NA	NA	p.Arg140Ala	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.462	-2	-0.462	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140C	140	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg140Cys	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.462	-4.435	1.973	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140D	140	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg140Asp	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.462	-3.212	0.75	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140E	140	R	E	missense	wt-like	0.952536273060459	0.169905083745995	6	0.069363459980422	0.816586389655747	1.08848615646517	0.862894547087377	0.91501495934905	0.682133794695058	1.02815806153473	NA	NA	1.15952531774272	1.06749095795382	0.684407269831016	0.65707589092939	0.655164617657741	0.622625879823559	0.733662292638827	NA	NA	0.724251960576686	0.711738648732642	NA	NA	p.Arg140Glu	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.462	-3.035	0.573	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140F	140	R	F	missense	low	0.410570660094272	0.348112436514408	6	0.142116307096217	0.132027816569853	0.689113503618692	0.766090526372886	0.927017459007109	0.137690927653787	0.24651396191399	NA	NA	0.101414750134515	0.284696335483346	0.521140114619648	0.636456753600196	0.657759699347914	0.459720405756141	0.474778739909851	NA	NA	0.506593247524564	0.535686981714733	NA	NA	p.Arg140Phe	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.462	-3.744	1.282	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140G	140	R	G	missense	wt-like	0.938875819959314	0.0395135634718663	6	0.0161313447375248	0.907258965251566	0.970492674667062	0.93859824721174	1.00662083199897	0.948546926771946	0.924366326292903	NA	NA	0.929377457131628	0.885745130348698	0.675940131633874	0.673200685929343	0.674970885485167	0.702340685923648	0.699286067990873	NA	NA	0.676909377782581	0.67086374361072	NA	NA	p.Arg140Gly	1	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.462	-2.965	0.503	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140H	140	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg140His	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.462	-4.067	1.605	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140I	140	R	I	missense	wt-like	1.24104374692468	0.214343823734775	6	0.0875054996112096	1.06953611923753	1.41255137461183	1.54002118512462	1.34187132453459	1.01895488401886	1.11228202608967	NA	NA	1.39413532448599	1.03899773729435	0.754490231596222	0.801303031867303	0.747455987721053	0.72340780305893	0.761524475471391	NA	NA	0.772512429472975	0.705330481313227	NA	NA	p.Arg140Ile	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.462	-3.311	0.849	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140K	140	R	K	missense	possibly_wt-like	0.887619245285976	0.216539731555834	6	0.0884019752251731	0.714354557682435	1.06088393288952	1.03382157276404	0.981513594438932	1.11250100596957	0.951282472718159	NA	NA	0.693655323305718	0.552941502519438	0.681512771178553	0.693483137133475	0.669542405223631	0.751398206214296	0.708200799920308	NA	NA	0.628420138701996	0.596015716060353	NA	NA	p.Arg140Lys	1	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.462	-2.544	0.082	0.00794625	NA	NA	NA	NA	4.06e-06	NA	NA
R140L	140	R	L	missense	wt-like	1.11256489769135	0.115659644838119	6	0.0472178522808196	1.02001960779362	1.20511018758909	0.983154626520171	1.21540116899202	0.970255447431851	1.14590124445044	NA	NA	1.1132055588676	1.24747133988604	0.717417701362673	0.682691139911227	0.720111651595081	0.708836200996924	0.772659290783669	NA	NA	0.714723751130264	0.752216502514631	NA	NA	p.Arg140Leu	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.462	-3.443	0.981	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140M	140	R	M	missense	possibly_low	0.502291122827087	0.510375476905675	6	0.20835991594142	0.0939131917601099	0.910669053894064	1.25789846468165	0.977181779861794	0.393898844811654	0.32606290151497	NA	NA	-0.0595426547149496	0.118247400807402	0.518753657602457	0.741211239464834	0.668605815928516	0.536381658444138	0.501125656760776	NA	NA	0.473483492581906	0.498252370410718	NA	NA	p.Arg140Met	1	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.462	-3.88	1.418	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140N	140	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg140Asn	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.462	-3.135	0.673	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140P	140	R	P	missense	possibly_low	0.656905854475762	0.130465979635017	6	0.0532625131496888	0.552513246976281	0.761298461975243	0.721456927167912	0.870322013384817	0.577520841741339	0.488422044570902	NA	NA	0.630635469497637	0.653077830491966	0.616996579568804	0.62694985187534	0.645501476724112	0.591324114796989	0.554899633680382	NA	NA	0.615456634984605	0.618536524153003	NA	NA	p.Arg140Pro	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.462	-2.437	-0.025	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140Q	140	R	Q	missense	wt-like	1.00985387178288	0.183058588867205	6	0.0747333559597635	0.863379185657927	1.15632855790782	0.834185423681554	0.810732016332998	0.983715202520588	0.986130285169695	NA	NA	1.16911235943866	1.27524794355376	0.71630304600435	0.650960882960337	0.632617418013659	0.712863561655496	0.719742530353205	NA	NA	0.726224063702197	0.758463501713942	NA	NA	p.Arg140Gln	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.462	-3.132	0.67	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140R	140	R	R	synonymous	possibly_wt-like	0.734819177207587	0.0629935380297676	6	0.025717004210923	0.684414775163913	0.785223579251261	0.786332151436286	0.675230614943743	0.698275665222693	0.805390615958244	NA	NA	0.66274974374789	0.780936271936666	0.634111982249828	0.640768194838564	0.603320420241874	0.627455769661091	0.659880851991885	NA	NA	0.622062704159127	0.647292076519486	NA	NA	p.Arg140=	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140S	140	R	S	missense	possibly_wt-like	0.750651913685582	0.177481717813402	6	0.0724566078859113	0.608639571787255	0.892664255583909	0.928383811811107	0.917752634790835	0.53207239798286	0.625737472698575	NA	NA	0.881523458047218	0.618441706782896	0.633251672036145	0.671025023754246	0.655756535309482	0.57772525856376	0.600379035233392	NA	NA	0.667065567339733	0.610746808762808	NA	NA	p.Arg140Ser	1	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.462	-2.324	-0.138	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140T	140	R	T	missense	wt-like	0.891462834963711	0.155362453355146	6	0.06342645598451	0.767149265567056	1.01577640436037	0.613466039692047	0.837162942355707	0.980950508657462	1.05601453444626	NA	NA	0.964572029730861	0.896610954899929	0.678728281781305	0.603947925687443	0.638332095300052	0.712036323773087	0.742888464341951	NA	NA	0.68414907995821	0.673307483604399	NA	NA	p.Arg140Thr	1	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.462	-2.86	0.398	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140V	140	R	V	missense	wt-like	0.887291398075524	0.148247037059369	6	0.0605215994458204	0.768671242874957	1.00591155327609	0.998956080945049	1.10392826317924	0.825987879896115	0.921920945704823	NA	NA	0.74086296116483	0.732092257563087	0.675863005308445	0.686056830265644	0.696009897371672	0.665669180351246	0.698476148470309	NA	NA	0.638130989360894	0.636306985529493	NA	NA	p.Arg140Val	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.462	-2.878	0.416	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140W	140	R	W	missense	wt-like	0.852733730071663	0.0962123572106562	6	0.0392785303527489	0.775749225214612	0.929718234928714	0.855965326176808	1.03367334701695	0.864915871607473	0.80519602331908	NA	NA	0.773167730571819	0.783484081737844	0.657708188777808	0.655599975399386	0.680819957628165	0.677317019505966	0.659816402156229	NA	NA	0.644776244355809	0.647865082707656	NA	NA	p.Arg140Trp	1	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.462	-5.932	3.47	0.00794625	NA	NA	NA	NA	NA	NA	NA
R140X	140	R	X	nonsense	low	-0.217921890393483	0.112151463089904	6	0.0457856430794745	-0.307660101838259	-0.128183678948707	-0.231365622982829	-0.114747047327748	-0.183840300136349	-0.0866393003699336	NA	NA	-0.369244462243974	-0.321694609300065	0.40454251081351	0.42399982080323	0.432517951971881	0.363513438484659	0.364437089297816	NA	NA	0.409776259216816	0.399308762410204	NA	NA	p.Arg140Ter	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R140Y	140	R	Y	missense	wt-like	1.11025461151694	0.202898216025737	3	0.117143339640554	0.880657884792706	1.33985133824117	NA	0.90189729889227	1.12165337359944	1.30721316205909	NA	NA	NA	NA	0.754136731921661	NA	0.652328425077937	0.754136731921661	0.82608642257973	NA	NA	NA	NA	NA	NA	p.Arg140Tyr	0	14.1	24.5	2.3	0.381	102.8	73	-91.2	1.3	60	-2.2	0	0	15.1	0	0	0	0	5	19.0562110898041	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.462	-4.751	2.289	0.00794625	NA	NA	NA	NA	NA	NA	NA
T141A	141	T	A	missense	possibly_wt-like	0.832106747718615	0.211176184086362	6	0.0862123161399391	0.663133713060553	1.00107978237668	1.08837476309767	1.1112961142515	0.658107346076665	0.765448640879858	NA	NA	0.660372392287874	0.709041229718115	0.638887345241768	0.705102899566199	0.697602913489836	0.615436805929349	0.646651915169715	NA	NA	0.621573670900127	0.631122775313822	NA	NA	p.Thr141Ala	1	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.655	-2.154	-0.501	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141C	141	T	C	missense	possibly_low	0.63256870294577	0.420309500958183	6	0.171590635231898	0.296257237806901	0.968880168084639	1.0631783823297	1.10649845938048	0.738929887462727	0.559413288153395	NA	NA	0.0717210453488138	0.255671154999508	0.609016165679326	0.699736101457825	0.696565604040449	0.63962012288854	0.578412208470112	NA	NA	0.50048510177188	0.529159175744952	NA	NA	p.Thr141Cys	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.655	-5.531	2.876	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141D	141	T	D	missense	possibly_low	0.597789332607986	0.247352412549907	6	0.100981199565612	0.399869818343736	0.795708846872237	0.851668062565921	0.796484836530278	0.553858363964524	0.668729246648481	NA	NA	0.157973553389145	0.558021932549568	0.605888194765843	0.654684663536525	0.629537010057321	0.584243946439214	0.614618077252225	NA	NA	0.51822768035704	0.59715831227946	NA	NA	p.Thr141Asp	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.655	-2.276	-0.379	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141E	141	T	E	missense	possibly_low	0.602136290156111	0.231561350951381	6	0.094534525663404	0.416852024560262	0.78742055575196	0.789787134984291	0.9713296092432	0.491611592372724	0.344913621315184	NA	NA	0.494767199441439	0.520408583579828	0.588103428455777	0.641504102084158	0.667340507763322	0.565618778493796	0.507369088158449	NA	NA	0.587507842381675	0.588699014529879	NA	NA	p.Thr141Glu	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.655	-2.2	-0.455	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141F	141	T	F	missense	wt-like	1.00240409176977	0.327135527574286	6	0.133552519882196	0.740645962756098	1.26416222078345	1.45422086585159	1.3371920990827	0.787260597853045	0.641893460581787	NA	NA	0.796027495160446	0.997830032089063	0.675076600067963	0.78302766940899	0.746444284105945	0.654081396540515	0.605729960984743	NA	NA	0.649478613931686	0.696071803595411	NA	NA	p.Thr141Phe	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.655	-4.149	1.494	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141G	141	T	G	missense	wt-like	0.860188279514757	0.0696077719552727	6	0.0284172539037385	0.804491485323899	0.915885073705614	0.88131175501312	0.92438950575739	0.805323765954176	0.95433313550731	NA	NA	0.801174650853646	0.794596864002899	0.658338836181323	0.660998733561735	0.65719150492548	0.659486167437167	0.709211191249836	NA	NA	0.650537409976596	0.650364363856006	NA	NA	p.Thr141Gly	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.655	-2.715	0.06	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141H	141	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr141His	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.655	-4.076	1.421	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141I	141	T	I	missense	possibly_wt-like	0.840050896263957	0.406535226242827	6	0.165967311126974	0.514760943844135	1.16534084868378	0.632413930050162	0.527844802605937	1.39647068570627	1.16669734582146	NA	NA	0.339454767727934	0.977423845671979	0.649733112574585	0.607983803025066	0.571453872948764	0.836366194774193	0.779547040091127	NA	NA	0.555559287058036	0.691482422124103	NA	NA	p.Thr141Ile	1	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.655	-3.224	0.569	0.008073773	NA	NA	NA	NA	4.06e-06	NA	NA
T141K	141	T	K	missense	wt-like	0.981960569657248	0.231369416808894	6	0.0944561688778519	0.796829880539025	1.16709125877547	1.25228697999753	1.14646219196104	1.06378262068172	0.651993824452892	NA	NA	0.757234639762545	1.02000316108776	0.703132403221708	0.740016000130057	0.705206233379783	0.736820934416713	0.609075240612742	NA	NA	0.641498726725181	0.701058573063632	NA	NA	p.Thr141Lys	1	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.655	-2.788	0.133	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141L	141	T	L	missense	wt-like	0.978303798913183	0.0644673002279999	6	0.0263186651089016	0.926720163178565	1.0298874346478	0.926589660255655	1.02855125874383	0.996780103717639	0.878656907702667	NA	NA	0.988835510059853	1.05040935299946	0.686643566263971	0.670642871680001	0.679712501858807	0.716772776105702	0.684146931543022	NA	NA	0.68914020098492	0.707896970543711	NA	NA	p.Thr141Leu	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.655	-3.391	0.736	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141M	141	T	M	missense	wt-like	1.22636511416645	0.255204987643018	6	0.104186999923113	1.02216234665987	1.43056788167303	1.07615128163075	1.05367736936027	1.29566598500458	0.908918071586379	NA	NA	1.56005367748272	1.46372429993398	0.751675712875404	0.7024993130504	0.685145062697266	0.806203915956444	0.694169546208354	NA	NA	0.80664267662345	0.800852112700408	NA	NA	p.Thr141Met	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.655	-4.362	1.707	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141N	141	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr141Asn	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.655	-3.068	0.413	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141P	141	T	P	missense	possibly_low	0.6894109607471	0.225622908775967	6	0.0921101667972725	0.508878351214469	0.869943570279731	0.873381868204473	0.997291361413316	0.62383462270259	0.612554040799968	NA	NA	0.349415638935952	0.679988232426301	0.614885303103366	0.659309677426405	0.672953744140816	0.605181892903898	0.596012631535433	NA	NA	0.557608288811148	0.624588713302833	NA	NA	p.Thr141Pro	1	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.655	-3.463	0.808	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141Q	141	T	Q	missense	wt-like	0.989198907590383	0.134617355444471	6	0.0549573052269715	0.881484568658144	1.09691324652262	1.00425778095117	1.18293195112642	0.918977799913741	0.778719760294245	NA	NA	1.00243722140106	1.04786893185566	0.692715650786069	0.687186085845087	0.713091424544238	0.693493159543565	0.651047361312472	NA	NA	0.691938142028573	0.707325626075502	NA	NA	p.Thr141Gln	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.655	-2.759	0.104	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141R	141	T	R	missense	wt-like	0.856106864120226	0.0669631432777545	6	0.02733758876723	0.802526174712288	0.909687553528164	0.922339986715813	0.906959988651801	0.80187732925345	0.749518830593834	NA	NA	0.868241635480556	0.887703414025902	0.661394185454924	0.66973769644373	0.653423038189562	0.658454941869595	0.64137590031443	NA	NA	0.664333429040253	0.6713041645027	NA	NA	p.Thr141Arg	1	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.655	-3.189	0.534	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141S	141	T	S	missense	wt-like	0.9231302987527	0.101280511880515	6	0.041347595832525	0.842090500073633	1.00417009743177	0.824065032603887	0.934519264654091	0.792873153395277	0.92395173940968	NA	NA	1.01157828162253	1.05179432083074	0.676600091261704	0.648805252110344	0.659381678021719	0.655760757363637	0.699148755209652	NA	NA	0.693818504501689	0.708208451854982	NA	NA	p.Thr141Ser	1	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.655	-2.399	-0.256	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141T	141	T	T	synonymous	wt-like	1.01363492314359	0.111629526156479	6	0.0455725632186738	0.924314340551813	1.10295550573536	0.898554819044902	1.04022168496504	1.07900628733412	1.19222723372219	NA	NA	0.928781874853743	0.94301763894154	0.682990100382817	0.664671484989034	0.682235785363576	0.741376083879007	0.78800263782892	NA	NA	0.676786863485787	0.683744415402059	NA	NA	p.Thr141=	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141V	141	T	V	missense	wt-like	1.08065397084265	0.127551247737009	6	0.0520725788351668	0.978593591743599	1.1827143499417	0.99342429509369	0.923518676562933	1.2558813752848	0.998665574394597	NA	NA	1.1662124092433	1.14622149447658	0.724760897959569	0.684878566684204	0.657003221404365	0.794299763841809	0.723894266687685	NA	NA	0.725627529231452	0.729445262705412	NA	NA	p.Thr141Val	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.655	-3.205	0.55	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141W	141	T	W	missense	wt-like	0.839703479371681	0.0542445223504608	6	0.0221452335166044	0.796299619249907	0.883107339493455	0.811218609595419	0.911565526111789	0.900064700068248	0.77448561186761	NA	NA	0.827444522377687	0.813441906209335	0.654510725640801	0.646068979812505	0.654418809593545	0.687834076317518	0.649644994956734	NA	NA	0.655941255853395	0.654602641688057	NA	NA	p.Thr141Trp	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.655	-5.933	3.278	0.008073773	NA	NA	NA	NA	NA	NA	NA
T141X	141	T	X	nonsense	low	-0.120248190637438	0.110417756023048	6	0.0450778601332651	-0.208599172998772	-0.0318972082761046	-0.257172264833152	-0.209249395502021	-0.0484566980265813	-0.154281750209766	NA	NA	-0.0978416095779917	0.0455125743248836	0.415294234940441	0.418503037835025	0.412085432045857	0.404022243389205	0.342033647963935	NA	NA	0.465605203221679	0.481894200483473	NA	NA	p.Thr141Ter	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T141Y	141	T	Y	missense	possibly_low	0.645507204293475	0.21025663467026	5	0.094029625568608	0.461212524699217	0.829801883887734	0.809226683577873	0.908636132329469	0.492018659937734	NA	NA	NA	0.608499155597763	0.409155390024538	0.610903082886495	0.645644702021125	0.653785440180142	0.565740579216461	NA	NA	NA	0.610903082886495	0.563678006944695	NA	NA	p.Thr141Tyr	0	12.8	25.7	5.8	0.596	86	-119.1	-104.3	173.9	8.58895705521472	-2.6	0	0	14.59	2	3	0	0	6	18.5858332953083	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.655	-4.147	1.492	0.008073773	NA	NA	NA	NA	NA	NA	NA
N142A	142	N	A	missense	wt-like	1.03875762952699	0.0503536202939761	6	0.0205567794036822	0.998467082257638	1.07904817679634	0.994892880794261	1.02372313297656	1.09880202232551	1.04145548737992	NA	NA	1.09560385279413	0.978068400891558	0.701365187208866	0.685191373631852	0.678668604243024	0.747299264782839	0.738066451573336	NA	NA	0.711102990872542	0.691627383545189	NA	NA	p.Asn142Ala	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.849	-2.566	-0.283	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142C	142	N	C	missense	wt-like	1.16753129795114	0.18479501549968	6	0.0754422491639875	1.01966720667702	1.31539538922525	1.04232008977099	0.903029081399017	1.1468684314533	1.16648638833279	NA	NA	1.37798380784904	1.36849998890168	0.765435718036489	0.695293310801547	0.652573129776474	0.761681455531767	0.77947717015394	NA	NA	0.769189980541211	0.77943602447415	NA	NA	p.Asn142Cys	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.849	-4.447	1.598	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142D	142	N	D	missense	wt-like	0.928373766368764	0.186362353405175	6	0.0760821121844852	0.779255566619437	1.07749196611809	1.22497790224394	0.961099002955622	0.651534812077751	0.880909670047376	NA	NA	0.872454611878455	0.979266599009439	0.675046557409583	0.734199200162671	0.665128530274247	0.61347020514948	0.684893055155463	NA	NA	0.665200059663703	0.691896860072001	NA	NA	p.Asn142Asp	1	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.849	-2.209	-0.64	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142E	142	N	E	missense	possibly_wt-like	0.834401215036053	0.23163991039169	6	0.09456659742061	0.649054089951159	1.01974834012095	0.380598383673774	0.821968519407291	1.01319796740734	0.919341389120459	NA	NA	0.971060297263926	0.90024073334353	0.679803787826293	0.554347401416558	0.635046882226981	0.721685247238035	0.697621789340176	NA	NA	0.685483749513942	0.674123826138645	NA	NA	p.Asn142Glu	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.849	-2.866	0.017	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142F	142	N	F	missense	possibly_wt-like	0.863158835351721	0.184881710063379	6	0.0754776420714102	0.715225375253752	1.01109229544969	0.863132313012192	0.957815668156772	0.775443657062418	1.15167693506895	NA	NA	0.598460867772765	0.832423571037223	0.657999090464198	0.657126534778889	0.664418634647341	0.650545590566997	0.774572221883013	NA	NA	0.608838156142427	0.658871646149507	NA	NA	p.Asn142Phe	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.849	-3.538	0.689	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142G	142	N	G	missense	wt-like	0.907771835827055	0.0913135887694548	6	0.0372786165112501	0.834707090071525	0.980836581582586	0.883980828747588	1.06001827169487	0.932172566756247	0.936337829426961	NA	NA	0.810837508406807	0.823284009929862	0.674041641697722	0.661567242983829	0.686516040411615	0.69744123174326	0.703251076188792	NA	NA	0.652525108808658	0.656816145354566	NA	NA	p.Asn142Gly	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.849	-3.999	1.15	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142H	142	N	H	missense	wt-like	1.03847793291242	0.264537508381101	6	0.107996985560154	0.826807730775629	1.25014813504922	1.41448204779445	1.21006564125324	0.730341128884374	0.823412777909044	NA	NA	1.16336014517283	0.889205856460609	0.695300056863494	0.774563350047331	0.718958047701161	0.637050237465188	0.665849861821223	NA	NA	0.725040804038577	0.671642066025827	NA	NA	p.Asn142His	1	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.849	-3.009	0.16	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142I	142	N	I	missense	wt-like	0.977045785103086	0.250383521084514	6	0.102218644443076	0.776700923446153	1.17739064676002	0.652690845919107	0.836484166997084	1.10713291573004	1.3534856300551	NA	NA	0.83582356881584	1.07665758310135	0.685732552247351	0.612302761161603	0.638185336078632	0.749791993077444	0.841412043171194	NA	NA	0.657664868224506	0.713800236270197	NA	NA	p.Asn142Ile	1	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.849	-2.506	-0.343	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142K	142	N	K	missense	possibly_low	0.559463661412126	0.284378454471381	6	0.116097017882697	0.331917687649538	0.787009635174715	0.831275626608472	0.956481003492152	0.325112651318762	0.343243732968221	NA	NA	0.604219501250711	0.296449452834441	0.574176505720227	0.650341099763244	0.664130064438438	0.515799797355299	0.506816014671254	NA	NA	0.610022736270552	0.538330275169901	NA	NA	p.Asn142Lys	1	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.849	-3.573	0.724	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142L	142	N	L	missense	possibly_low	0.7166268212012	0.0927150960751873	6	0.037850779472888	0.642440656647572	0.790812985754829	0.763148827010699	0.794122282518479	0.695519053110666	0.816931549760875	NA	NA	0.572264646199438	0.657774568607046	0.627828574016809	0.635830175254767	0.629026198073756	0.626630949959861	0.663703253959845	NA	NA	0.60344946043422	0.619592827493586	NA	NA	p.Asn142Leu	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.849	-2.5	-0.349	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142M	142	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn142Met	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.849	-3.375	0.526	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142P	142	N	P	missense	wt-like	1.09959926972357	0.12896796673297	6	0.0526509519433352	0.996405300162879	1.20279323928425	0.968040663119703	1.12156134328779	1.31567479403589	1.12757428737213	NA	NA	1.09894368740717	0.965800843118706	0.705806194312419	0.679471884299295	0.699822376824677	0.812190851809757	0.766589331627773	NA	NA	0.711790011800161	0.688868391679184	NA	NA	p.Asn142Pro	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.849	-3.96	1.111	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142Q	142	N	Q	missense	wt-like	0.973587359758942	0.142175692965222	6	0.058042983598567	0.859825202350502	1.08734951716738	1.02911401305199	1.16795055874426	0.864264139167505	1.05321020678003	NA	NA	0.769481162566303	0.95750407824356	0.689741434853862	0.69248043270579	0.709852271186868	0.677122011382019	0.741959660159073	NA	NA	0.644017898609888	0.687002437001933	NA	NA	p.Asn142Gln	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.849	-2.673	-0.176	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142R	142	N	R	missense	wt-like	0.937277703415396	0.0845015712424513	6	0.0344976220012411	0.869663606740687	1.0048918000901	0.921005851180698	1.04973488368488	0.913142239220205	1.01214207763743	NA	NA	0.917728354282411	0.80991281448675	0.67940287455351	0.669453527215931	0.684292650892938	0.691747072233439	0.728357736749776	NA	NA	0.674513098214082	0.653808943746113	NA	NA	p.Asn142Arg	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.849	-3.603	0.754	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142S	142	N	S	missense	possibly_wt-like	0.728353146890616	0.176477604626026	6	0.0720466803937326	0.587144248113232	0.869562045667999	0.737746142301585	0.632143824059189	1.00593946178543	0.818486188244896	NA	NA	0.483628243380558	0.692175021572038	0.628874487422998	0.630419434660714	0.594004548940205	0.719513393456968	0.664218156246126	NA	NA	0.585216502596234	0.627329540185281	NA	NA	p.Asn142Ser	1	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.849	-3.155	0.306	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142T	142	N	T	missense	wt-like	1.03995961063862	0.119866484701807	6	0.0489352874634254	0.944048209637188	1.13587101164004	1.0156599877361	1.20543135921818	0.990894716148906	1.169741727234	NA	NA	0.929399991075462	0.928629882419042	0.702313260855438	0.689614741863909	0.717956061381736	0.715011779846967	0.780555351004396	NA	NA	0.676914013129175	0.680508587705083	NA	NA	p.Asn142Thr	1	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.849	-2.784	-0.065	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142V	142	N	V	missense	possibly_wt-like	0.889868811770038	0.218657195113163	6	0.0892664261025719	0.714909831580391	1.06482779195968	1.05995163592083	1.12371276996188	0.530156329148015	0.745162521253021	NA	NA	0.934574940588963	0.945654673747513	0.681158007464789	0.699048808442102	0.700287540592953	0.577151942021691	0.639933073790846	NA	NA	0.677978526503958	0.68433748842562	NA	NA	p.Asn142Val	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.849	-2.533	-0.316	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142W	142	N	W	missense	wt-like	0.847089224069859	0.134120043604775	6	0.0547542785185881	0.739772810173951	0.954405637965767	1.04503508429432	0.764063513253016	0.736923762313762	0.968488720927185	NA	NA	0.851218501715904	0.716805761914967	0.649925772094273	0.695871601295179	0.622527138380173	0.639019860146176	0.713899575958726	NA	NA	0.660831684042371	0.632869030075455	NA	NA	p.Asn142Trp	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.849	-4.547	1.698	0.00840831	NA	NA	NA	NA	NA	NA	NA
N142X	142	N	X	nonsense	low	0.2311030090371	0.162170843433056	6	0.0662059695946278	0.101341693070076	0.360864325004124	0.187315130605122	0.0599136990130267	0.284248126626189	0.389469262931157	NA	NA	0.423050893662672	0.0426209413844329	0.508375412379138	0.513178306279383	0.470281661010316	0.503572518478893	0.522126089204397	NA	NA	0.572755434364483	0.48124386796335	NA	NA	p.Asn142Ter	0	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N142Y	142	N	Y	missense	wt-like	1.04799668496045	0.113292386428483	6	0.0462514230819996	0.957345561486004	1.13864780843489	0.862680415077965	1.05691339941631	1.08163657691457	1.14363786939713	NA	NA	1.16738191888749	0.97572993006922	0.70848478065123	0.657030281074799	0.685844730482021	0.742163105983581	0.77190965220104	NA	NA	0.725868103299842	0.691101458002617	NA	NA	p.Asn142Tyr	1	13.1	28.9	7.8	0.27	63	135.4	-103.5	40.4	78.6096256684492	-0.5	0	0	16.88	0	0	0	0	4	20.4717907732277	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.849	-3.54	0.691	0.00840831	NA	NA	NA	NA	NA	NA	NA
I143A	143	I	A	missense	low	0.286367213631044	0.279732103742894	5	0.125099999891627	0.0411757193774905	0.531558707884597	-0.00361438822884678	NA	0.123290188586826	0.731274265335985	NA	NA	0.33703294219058	0.243853060270674	0.526501268781538	0.472510553638761	NA	0.45541148857375	0.635333229648536	NA	NA	0.555061105255648	0.526501268781538	NA	NA	p.Ile143Ala	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.951	-2.311	0.36	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143C	143	I	C	missense	wt-like	1.46587550599302	0.288389369443545	6	0.117734467063279	1.23512019080998	1.69663082117607	1.16077412361722	1.09526209547845	1.49448558745561	1.53942355791016	NA	NA	1.66695227531112	1.83835539618557	0.847162992267544	0.720523874295143	0.694136169917809	0.865693723890187	0.902995404925653	NA	NA	0.828632260644901	0.885107199690774	NA	NA	p.Ile143Cys	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.951	-3.142	1.191	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143D	143	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile143Asp	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.951	-3.533	1.582	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143E	143	I	E	missense	possibly_low	0.647729697253963	0.365336737954633	6	0.149148098713623	0.355404795412637	0.94005459909529	1.06707440188394	1.0163941685229	0.332534110033831	0.461894651013252	NA	NA	0.804681703404717	0.203799148665137	0.598686243344377	0.700565948830209	0.67708399586948	0.518020409146615	0.546113658206153	NA	NA	0.651258828482601	0.517493084889717	NA	NA	p.Ile143Glu	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.951	-2.864	0.913	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143F	143	I	F	missense	wt-like	1.27561587785471	0.314373901614715	6	0.128342607900662	1.02406898868746	1.52716276702195	1.77065130850564	1.3930871160305	1.42085457592357	0.90592027932404	NA	NA	1.11501818567408	1.04816380167041	0.736813031146008	0.850426964438943	0.758529444629631	0.843662220557476	0.693176665802049	NA	NA	0.715096617662385	0.707391942732449	NA	NA	p.Ile143Phe	1	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.951	-3.804	1.853	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143G	143	I	G	missense	low	0.332563482272779	0.094599103518323	6	0.0386199222907694	0.256869825497135	0.408257139048422	0.495058457234763	0.282902336525691	0.212047289756855	0.353812604322401	NA	NA	0.305700270607642	0.34585993518932	0.53355512231697	0.578727256282549	0.518494428917969	0.481968944862101	0.510316465791954	NA	NA	0.548615815715971	0.549442765645733	NA	NA	p.Ile143Gly	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.951	-3.244	1.293	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143H	143	I	H	missense	wt-like	1.04015327664302	0.333396796454256	6	0.136108672198578	0.773385181150236	1.3069213721358	0.538789957099247	0.820125401191954	1.04247222456241	1.13021813488176	NA	NA	1.51284589522445	1.19646804689829	0.735595165376714	0.588042011957594	0.634648378376141	0.730444544179025	0.767464984161322	NA	NA	0.796931796260911	0.740745786574404	NA	NA	p.Ile143His	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.951	-5.315	3.364	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143K	143	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile143Lys	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.951	-3.665	1.714	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143L	143	I	L	missense	wt-like	1.06193741134788	0.195843389665387	6	0.0799527290295423	0.905232941984285	1.21864188071147	0.785109075126602	0.847097797726342	1.14649787692053	1.22929623258469	NA	NA	1.13139338824406	1.23223009748503	0.733626902254186	0.640507681089163	0.640480127960027	0.761570580056152	0.800280033802724	NA	NA	0.718465079925649	0.748788724582722	NA	NA	p.Ile143Leu	1	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.951	-1.752	-0.199	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143M	143	I	M	missense	possibly_low	0.688865879552098	0.569191571425934	6	0.232371485981077	0.233426135995132	1.14430562310906	1.48207874274842	0.934243438664215	0.576305866494035	0.630365558949054	NA	NA	-0.263600504971873	0.77380217542874	0.623799741498778	0.788961362918783	0.659322041196358	0.590960575974784	0.60191187532192	NA	NA	0.431507757309266	0.645687607675636	NA	NA	p.Ile143Met	1	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.951	-3.577	1.626	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143N	143	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile143Asn	1	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.951	-4.44	2.489	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143P	143	I	P	missense	possibly_wt-like	0.761118946350798	0.54142237935244	6	0.221034760789511	0.327898775871931	1.19433911682967	1.26823394894319	1.37244994247721	0.821243680338828	0.775605434232291	NA	NA	-0.0796248803733206	0.408805552486593	0.657132764563588	0.743412684898396	0.754067444817024	0.664249644666721	0.650015884460454	NA	NA	0.469352476858375	0.563599327965595	NA	NA	p.Ile143Pro	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.951	-4.462	2.511	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143Q	143	I	Q	missense	possibly_low	0.591161876346188	0.238688373044734	6	0.0974441202491136	0.400174910152735	0.782148842539641	0.750311612555829	0.6263083681928	0.214119608455361	0.754446150618174	NA	NA	0.389605304993552	0.812180213261411	0.612919359534339	0.633095864367516	0.592742854701163	0.482589013707586	0.643007847787651	NA	NA	0.565875507058354	0.654318885080167	NA	NA	p.Ile143Gln	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.951	-4.552	2.601	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143R	143	I	R	missense	low	0.473346031167598	0.127196108390574	6	0.051927593804108	0.371569817507722	0.575122244827475	0.651547115053905	0.605621533349924	0.461379087210442	0.405987524990479	NA	NA	0.346679582966329	0.368861343434513	0.556809113793404	0.61205914789427	0.588270117533257	0.556572759372503	0.527597001565791	NA	NA	0.557045468214305	0.55461581634011	NA	NA	p.Ile143Arg	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.951	-4.464	2.513	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143S	143	I	S	missense	low	0.364214362078432	0.33554407015224	6	0.136985293014938	0.0957281213574867	0.632700602799377	0.798398851663867	0.783083023708457	0.105747836692754	0.226318334919195	NA	NA	0.069241073612896	0.202497051873423	0.50858760019953	0.643338387143247	0.626639380391847	0.450162553700029	0.468089870041149	NA	NA	0.499974959001389	0.51720024139767	NA	NA	p.Ile143Ser	1	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.951	-3.368	1.417	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143T	143	I	T	missense	possibly_low	0.553628260796717	0.336982857131947	4	0.168491428565974	0.223391129103705	0.883865392489729	0.901478725312396	NA	0.328548490043844	0.7763865109864	NA	NA	0.208099316844227	NA	0.589406692182485	0.665294273427181	NA	0.516827851849557	0.650274580106153	NA	NA	0.528538804258817	NA	NA	NA	p.Ile143Thr	1	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.951	-2.655	0.704	0.007159336	1.073482428	0.019999999825018	NA	NA	8.94e-05	NA	NA
I143V	143	I	V	missense	wt-like	1.26817333342711	0.175329672497265	6	0.0715780390645973	1.1278829547765	1.40846371207772	1.20273439169148	0.970186033352208	1.41435385941799	1.2617891849668	NA	NA	1.46427682516776	1.29569970596643	0.775002012692242	0.729461359777742	0.667093253196309	0.841717108649086	0.811041825461377	NA	NA	0.786940892090496	0.763063133293987	NA	NA	p.Ile143Val	1	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.951	-1.962	0.011	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143W	143	I	W	missense	low	0.615259056662728	0.109470486787826	6	0.0446911390873768	0.527666033623399	0.702852079702056	0.619354992288434	0.763064039874027	0.667807061757054	0.555160782207339	NA	NA	0.439971663758359	0.646195800091154	0.611095505347614	0.605202265346207	0.622311040472277	0.618339106385262	0.577003762032852	NA	NA	0.576236122636223	0.616988745349021	NA	NA	p.Ile143Trp	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.951	-5.763	3.812	0.007159336	NA	NA	NA	NA	NA	NA	NA
I143X	143	I	X	nonsense	low	-0.0473749686777386	0.189821118988266	6	0.0774941473208972	-0.199260706439338	0.104510769083861	0.199565496767552	0.182493099426631	-0.157965865648848	-0.122130140452285	NA	NA	-0.248094824751764	-0.138117577407718	0.437646431247204	0.515787619202253	0.496784770084942	0.371255457476146	0.352682385623454	NA	NA	0.434697354412842	0.440595508081565	NA	NA	p.Ile143Ter	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I143Y	143	I	Y	missense	possibly_low	0.455712988331966	0.331705291988154	5	0.148343116276386	0.164965823075813	0.746460153588119	0.473883725456883	1.01057244794983	NA	0.379662044710413	NA	NA	0.243530883543737	0.170915839998971	0.53582725732348	0.574217064461853	0.675825271362511	NA	0.51887790055101	NA	NA	0.53582725732348	0.510097580192108	NA	NA	p.Ile143Tyr	0	14.9	27.1	10.6	0.795	49.1	-165.2	-59.6	-27.6	2.61780104712042	-1	0	0	15.99	0	0	0	0	4	17.5570560591122	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.951	-4.567	2.616	0.007159336	NA	NA	NA	NA	NA	NA	NA
G144A	144	G	A	missense	possibly_low	0.710573535462065	0.286216204665742	6	0.116847276257844	0.481557082305088	0.939589988619043	0.883571180662569	1.19137564737477	0.442839107189662	0.669135792857617	NA	NA	0.449612052555552	0.626907432132219	0.613701744915678	0.661479988445646	0.714917051051693	0.551025319195907	0.61475272693105	NA	NA	0.578219199531166	0.612650762900306	NA	NA	p.Gly144Ala	1	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.549	-2.012	0.463	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144C	144	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly144Cys	1	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.549	-4.297	2.748	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144D	144	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly144Asp	1	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.549	-2.719	1.17	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144E	144	G	E	missense	possibly_wt-like	0.851422039558475	0.168786713393988	6	0.0689068871961098	0.716367022367335	0.986477056749614	1.08287005872272	0.908238430316414	0.722715773940873	0.679129194374295	NA	NA	0.997998647260005	0.717580132736538	0.644234034593711	0.70393040430592	0.653699452324143	0.63476861686328	0.618062580213049	NA	NA	0.691025104804578	0.633043187217207	NA	NA	p.Gly144Glu	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.549	-2.605	1.056	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144F	144	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly144Phe	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.549	-4.725	3.176	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144G	144	G	G	synonymous	wt-like	1.09760697232949	0.282883923329198	8	0.100014570237366	0.901582016734997	1.29363192792397	0.862923125264606	1.02459155091723	0.98332612656765	0.977846495220968	1.6451229463403	1.43314054720221	0.956535691607888	0.897369295515034	0.697621554359833	0.657081978045984	0.67885636642269	0.71274714429309	0.716998907043021	0.746527555818673	0.755364260611872	0.682495964426577	0.673478035529035	NA	NA	p.Gly144=	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144H	144	G	H	missense	possibly_wt-like	0.772215106698675	0.138931268858322	6	0.0567184530033854	0.661048981553212	0.883381231844138	1.0004903747967	0.767955974628344	0.661007995073294	0.628670644967858	NA	NA	0.713632229090276	0.861533421635578	0.627949111967555	0.686383632968642	0.623368734342064	0.616304723627429	0.601350513247754	NA	NA	0.632529489593046	0.665418494553126	NA	NA	p.Gly144His	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.549	-5.099	3.55	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144I	144	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly144Ile	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.549	-3.817	2.268	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144K	144	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly144Lys	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.549	-2.847	1.298	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144L	144	G	L	missense	wt-like	0.793137214011895	0.0333457563359267	6	0.0136133480183666	0.766455542186887	0.819818885836904	0.810517477825299	0.8127465605588	0.820626788843333	0.735760223862565	NA	NA	0.769585104320861	0.809587128660514	0.644979459782104	0.645919639607963	0.63305298618557	0.664065061476077	0.636818996484516	NA	NA	0.644039279956245	0.653735696522656	NA	NA	p.Gly144Leu	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.549	-3.281	1.732	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144M	144	G	M	missense	wt-like	1.01587297085469	0.226995675947949	6	0.0926705966484392	0.834241938997916	1.19750400271147	0.690585057981965	1.29404958720473	1.22752272290902	0.848000074747484	NA	NA	0.990537947613248	1.04454243467172	0.698033946486562	0.620374181715612	0.737116365269688	0.785814429587554	0.673993269748981	NA	NA	0.689490401028533	0.706577491944592	NA	NA	p.Gly144Met	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.549	-5.15	3.601	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144N	144	G	N	missense	possibly_low	0.576757366171791	0.28817518357491	6	0.117647026048567	0.346173432228354	0.807341300115228	0.689644611265924	0.913817868636495	0.279957110916232	0.185577995046171	NA	NA	0.597208377404584	0.794338233761338	0.614377190120007	0.620173867721981	0.65490579255646	0.502288582200583	0.454596511707309	NA	NA	0.608580512518032	0.650306197532604	NA	NA	p.Gly144Asn	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.549	-3.228	1.679	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144P	144	G	P	missense	wt-like	1.11616526205153	0.13619327956816	6	0.0556006735563681	1.00718994436488	1.22514057973818	0.954094987537105	1.02966963021694	1.02288300046072	1.17056898156796	NA	NA	1.31475677776847	1.20501819475798	0.733625940945434	0.676501472555407	0.679954306934031	0.724583154431666	0.780829340843366	NA	NA	0.756183859613271	0.742668727459202	NA	NA	p.Gly144Pro	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.549	-3.435	1.886	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144Q	144	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly144Gln	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.549	-3.201	1.652	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144R	144	G	R	missense	possibly_wt-like	0.743503065044665	0.135276111147376	6	0.055226241116516	0.635261621454769	0.851744508634562	0.729125480148435	1.01239604187297	0.674938587417191	0.647268873822209	NA	NA	0.676269148226901	0.72102025878028	0.626713479245163	0.628583244226759	0.676219553831587	0.620472965856693	0.607510318666381	NA	NA	0.624843714263567	0.63381687664655	rs72552737	*10	p.Gly144Arg	1	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.549	-3.022	1.473	0.007519238	NA	NA	1.035	0.4	NA	NA	NA
G144S	144	G	S	missense	wt-like	0.929984469895287	0.0990385154434991	6	0.0404323046198874	0.850738609028355	1.00923033076222	0.841748976968636	1.11264697541577	0.851837309260121	0.891868346365765	NA	NA	0.934053678577981	0.947751532783447	0.681340187691847	0.652571910506218	0.697894985572587	0.673403717434632	0.688522611189837	NA	NA	0.677871300263198	0.684809075120496	NA	NA	p.Gly144Ser	1	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.549	-2.668	1.119	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144T	144	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly144Thr	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.549	-3.161	1.612	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144V	144	G	V	missense	possibly_low	0.547519437299612	0.309490361248366	6	0.126348910894689	0.299880122460162	0.795158752139063	0.877052310822469	0.967123635765782	0.361997456408282	0.54858444641558	NA	NA	0.279505464789857	0.250853309595705	0.559026532693737	0.660091477188861	0.666431126795061	0.526836284418939	0.574825654151611	NA	NA	0.543227411235863	0.528075635196222	NA	NA	p.Gly144Val	1	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.549	-3.066	1.517	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144W	144	G	W	missense	possibly_low	0.67540846833177	0.150539398820221	6	0.0614574522158127	0.554954075407186	0.795862861256355	0.77806440765372	0.866805765786204	0.718908380706009	0.663760233662492	NA	NA	0.438279009109988	0.58663301307221	0.623300854296965	0.639007175583402	0.644741222608617	0.633629387685281	0.612972320908649	NA	NA	0.575887934985816	0.603592986556218	NA	NA	p.Gly144Trp	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.549	-5.816	4.267	0.007519238	NA	NA	NA	NA	NA	NA	NA
G144X	144	G	X	nonsense	low	0.0218006965651342	0.1254378718343	6	0.0512097967357781	-0.0785686606926076	0.122170053822876	0.0359914003322639	0.0428269790451984	0.133139152072692	0.169402771394514	NA	NA	-0.142349549257833	-0.10820657419603	0.457404070194937	0.480946537881411	0.466587311050152	0.458358446212219	0.449239214994958	NA	NA	0.456449694177654	0.447322536891467	NA	NA	p.Gly144Ter	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G144Y	144	G	Y	missense	possibly_low	0.532408828019003	0.226303007227648	5	0.101205781534729	0.334049141183704	0.730768514854301	0.260200812656828	0.604118859671096	0.830860373804867	NA	NA	NA	0.357452094785315	0.609411999176908	0.587945221798091	0.528702866896432	0.587945221798091	0.667127103630524	NA	NA	NA	0.559261428559697	0.608716014182613	NA	NA	p.Gly144Tyr	0	17.3	30.1	10.6	0.389	22.2	-29.3	82.4	-154.3	37.1134020618557	-0.8	0	0	16.44	0	0	0	0	4	19.9298688407191	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.549	-4.031	2.482	0.007519238	NA	NA	NA	NA	NA	NA	NA
K145A	145	K	A	missense	possibly_wt-like	0.76576368763421	0.11524779903572	6	0.0470497169360555	0.673547936956737	0.857979438311683	0.661451567016491	0.725862700746071	0.778999702446262	0.663134349179226	NA	NA	0.793283049366977	0.971850757050232	0.631590870307524	0.614168783978388	0.614267673109543	0.651609612697012	0.61276502554404	NA	NA	0.648914067505505	0.690229026259935	NA	NA	p.Lys145Ala	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.367	-2.704	0.337	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145C	145	K	C	missense	wt-like	0.866664422861678	0.16610993962257	6	0.0678140988799696	0.733751231412899	0.999577614310456	0.868685695683403	0.995056041101008	0.874848497513367	0.638505470521339	NA	NA	0.730697102637216	1.09219372971373	0.665389920018478	0.65830939845639	0.672470441580566	0.680289010195692	0.604607845556654	NA	NA	0.63603982067595	0.717294338594908	NA	NA	p.Lys145Cys	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.367	-4.293	1.926	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145D	145	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys145Asp	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.367	-2.364	-0.003	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145E	145	K	E	missense	wt-like	1.40224036228891	0.189087170698349	4	0.0945435853491744	1.21693834003524	1.58754238454258	NA	NA	1.49601336143639	1.57154630381776	NA	NA	1.13803828861366	1.40336349528782	0.826713867675342	NA	NA	0.866150856786353	0.913634582766316	NA	NA	0.719831969650676	0.787276878564332	NA	NA	p.Lys145Glu	1	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.367	-2.522	0.155	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145F	145	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys145Phe	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.367	-3.845	1.478	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145G	145	K	G	missense	wt-like	0.924593331141335	0.0492360365841595	6	0.0201005277646993	0.885197020652277	0.963989641630393	0.860043072184127	0.988560725410062	0.921263814461866	0.875496181336152	NA	NA	0.955326100612772	0.946870092843033	0.682673616075679	0.656468530282726	0.671066077881197	0.694177169393324	0.683100086730447	NA	NA	0.682247145420911	0.684610837975744	NA	NA	p.Lys145Gly	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.367	-2.594	0.227	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145H	145	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys145His	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.367	-3.105	0.738	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145I	145	K	I	missense	wt-like	1.04866205307105	0.200866634024599	6	0.082003459951773	0.887938224957898	1.20938588118419	1.19913027074556	0.98484233232483	1.16033952186103	1.28477844202062	NA	NA	0.910277720248375	0.752604031225854	0.700837075717752	0.728693686449853	0.670262117532331	0.765712207887845	0.818655956424025	NA	NA	0.672980464985651	0.64092011372834	NA	NA	p.Lys145Ile	1	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.367	-4.028	1.661	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145L	145	K	L	missense	possibly_low	0.589941595458564	0.220232692221498	6	0.0899096201036808	0.413721978191671	0.766161212725457	0.769925539147172	0.94413093541879	0.552614081397644	0.448956210537001	NA	NA	0.418310463912126	0.405712342338651	0.577825971168585	0.637273606603497	0.661459834366151	0.583871638427296	0.541828396616012	NA	NA	0.571780303909874	0.562903660433716	NA	NA	p.Lys145Leu	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.367	-3.384	1.017	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145M	145	K	M	missense	possibly_wt-like	0.809175886125462	0.404377715323506	6	0.165086510982504	0.485612270266378	1.13273950198455	1.15905359905071	1.01686129502731	1.0620600674329	0.839764713646384	NA	NA	0.730346325228436	0.0469693163670352	0.674225340189139	0.720157404678972	0.677184994117604	0.736305520641287	0.671265686260673	NA	NA	0.635967663982973	0.482221823920801	NA	NA	p.Lys145Met	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.367	-4.437	2.07	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145N	145	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys145Asn	1	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.367	-3.138	0.771	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145P	145	K	P	missense	wt-like	0.838062853478193	0.113204108163581	6	0.0462153836312681	0.747482366029205	0.92864334092718	0.660008260696373	0.732961127948654	0.927527983867574	0.893022039023564	NA	NA	0.8890137259341	0.925843983398891	0.674244194176325	0.613861361507679	0.615802436616083	0.696051502860527	0.688904718665801	NA	NA	0.668606353452813	0.679882034899836	NA	NA	p.Lys145Pro	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.367	-2.607	0.24	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145Q	145	K	Q	missense	possibly_wt-like	0.867593402689916	0.180561898785169	5	0.080749735966015	0.709326828435408	1.02585997694442	0.949639808420018	1.09604452547364	NA	0.602228415859815	NA	NA	0.839936965716589	0.850117297979514	0.662850991477811	0.675552524883984	0.694305340491624	NA	0.592592744569036	NA	NA	0.658511014840085	0.662850991477811	NA	NA	p.Lys145Gln	1	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.367	-2.589	0.222	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145R	145	K	R	missense	possibly_wt-like	0.754877508319518	0.296970192346927	6	0.121237573344358	0.517256230991543	0.992498785647492	1.01191654610733	0.6150308958963	0.481895464405228	0.396736858640111	NA	NA	1.11304603221497	0.910639252653161	0.633383500476474	0.688817393401958	0.59030453245981	0.562711567235347	0.524533145047132	NA	NA	0.714690935688315	0.676462468493138	NA	NA	p.Lys145Arg	1	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.367	-2.877	0.51	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145S	145	K	S	missense	wt-like	0.969598609194781	0.141676492516135	6	0.0578391858686286	0.856235887997151	1.08296133039241	1.12220356571364	1.13886927467301	0.792135712785092	0.866339024436781	NA	NA	1.00106961204838	0.896974465511791	0.685862009374491	0.712308392909063	0.703564555296841	0.655540104069285	0.680067200904077	NA	NA	0.691656817844905	0.673389237678022	NA	NA	p.Lys145Ser	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.367	-2.771	0.404	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145T	145	K	T	missense	wt-like	0.979570247830482	0.275929104935487	6	0.112647585379136	0.758785037541974	1.20035545811899	0.729375673533384	0.654143304464142	1.29969147853728	1.30561810093931	NA	NA	0.965639494821768	0.922953434687004	0.681800304584246	0.628636535109978	0.598761095527888	0.807408404015705	0.825558132159949	NA	NA	0.684368662944173	0.679231946224319	NA	NA	p.Lys145Thr	1	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.367	-2.881	0.514	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145V	145	K	V	missense	wt-like	0.909240308232337	0.158857591833203	6	0.0648533402931111	0.782130096980719	1.03635051948395	1.00752606169229	1.02002108954355	1.00585721113096	1.01352329308535	NA	NA	0.704574051592089	0.703940142349787	0.682875202251941	0.687882225622486	0.677868178881396	0.719488782827149	0.728815200654916	NA	NA	0.630666176516692	0.629975533228837	NA	NA	p.Lys145Val	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.367	-3.317	0.95	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145W	145	K	W	missense	possibly_low	0.588873673260589	0.333309341750956	6	0.136072968965463	0.322175554818844	0.855571791702333	0.843410258183605	1.10180399466354	0.573859647417686	0.494458134186219	NA	NA	0.228686809805859	0.291023195306627	0.573563720231255	0.652925761361389	0.695550605516878	0.59022863052664	0.55689880993587	NA	NA	0.532773756030566	0.537109901835673	NA	NA	p.Lys145Trp	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.367	-5.943	3.576	0.008311706	NA	NA	NA	NA	NA	NA	NA
K145X	145	K	X	nonsense	low	0.185311038479378	0.354389340493845	6	0.144678842415228	-0.0982542819794156	0.468876358938171	0.783851815410883	0.354877306807388	0.109555128309888	0.00063162944532904	NA	NA	-0.258583380668503	0.12153373157128	0.475146611763449	0.640239886316326	0.534056264606366	0.451301752472479	0.393341559211295	NA	NA	0.432539805237454	0.498991471054418	NA	NA	p.Lys145Ter	1	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K145Y	145	K	Y	missense	wt-like	1.14657418394408	0.42106921864695	6	0.171900788679572	0.809654829218092	1.48349353867007	1.72213860407954	0.695411283860784	0.689265139009316	1.04982804128649	NA	NA	1.2184297712891	1.50437226413927	0.738604189713543	0.840093818073848	0.607683718379266	0.624759685033582	0.7408394738501	NA	NA	0.736368905576986	0.809993899899509	NA	NA	p.Lys145Tyr	0	20.7	30.6	12.3	0.736	46.9	-153	-112.9	151.1	46.0869565217391	-0.6	0	0	17.43	1	27	0	0	6	20.0361504923905	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.367	-3.977	1.61	0.008311706	NA	NA	NA	NA	NA	NA	NA
F146A	146	F	A	missense	low	0.444232392814342	0.111563403673281	6	0.0455455688279467	0.354964718256176	0.533500067372507	0.628153056441016	0.500412705451037	0.45227626258543	0.406599485722806	NA	NA	0.367352023805209	0.310600822880553	0.557573475935474	0.607076242187811	0.565522730680251	0.553849057675484	0.527799685330169	NA	NA	0.561297894195465	0.541512939199123	NA	NA	p.Phe146Ala	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.853	-2.707	0.854	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146C	146	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe146Cys	1	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.853	-2.22	0.367	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146D	146	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe146Asp	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.853	-4.443	2.59	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146E	146	F	E	missense	low	-0.0953457223402984	0.1750361843826	6	0.0714582230435141	-0.235401265904816	0.0447098212242194	0.0475051152318817	-0.0534509210446671	0.0886291205600309	-0.0336391767669677	NA	NA	-0.329776930014507	-0.291341542007561	0.431467653936528	0.483398944991489	0.445770895902518	0.44504037700189	0.381990935479304	NA	NA	0.417894930871166	0.406135212084944	NA	NA	p.Phe146Glu	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.853	-4.337	2.484	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146G	146	F	G	missense	low	-0.0120955612605062	0.0244630120783811	6	0.00998698286059591	-0.031669687981493	0.00747856546048057	-0.0390099930133692	-0.0165715083688734	-0.0198583582378245	-0.0110682096129842	NA	NA	-0.020048092500217	0.0339827941702312	0.459357996169376	0.464971333361388	0.453744658977363	0.41257929571344	0.389466527207288	NA	NA	0.481607724441387	0.479301135893721	NA	NA	p.Phe146Gly	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.853	-4.112	2.259	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146H	146	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe146His	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.853	-5.247	3.394	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146I	146	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe146Ile	1	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.853	-2.081	0.228	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146K	146	F	K	missense	low	0.0988308624748163	0.161600306967863	6	0.0659730490580654	-0.030473937629286	0.228135662578919	0.0466478774376663	0.373760316751712	0.0195940315883229	0.201793705572149	NA	NA	-0.0744546680572888	0.025643911556336	0.473920862321203	0.483216354395848	0.538138993600986	0.424384042651623	0.459967217829221	NA	NA	0.470416015767601	0.477425708874805	NA	NA	p.Phe146Lys	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.853	-4.287	2.434	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146L	146	F	L	missense	low	0.593686542400229	0.127132795954263	6	0.0519017466102188	0.491960988309476	0.695412096490981	0.58230850094403	0.749029726157426	0.744857703628067	0.532434219320697	NA	NA	0.440707423797185	0.512781680553966	0.592147560517265	0.597311408262409	0.619276656669097	0.641393814419934	0.569476636395664	NA	NA	0.576387472209763	0.586983712772121	NA	NA	p.Phe146Leu	1	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.853	-2.567	0.714	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146M	146	F	M	missense	possibly_low	0.508175386705772	0.458121046726145	4	0.229060523363072	0.0592250106342551	0.957125762777289	0.188206724543491	1.17279180416185	NA	NA	NA	NA	0.221530217018014	0.450172801099738	0.552102245934594	0.513368214691466	0.710899005425462	NA	NA	NA	NA	0.531301608578565	0.572902883290623	NA	NA	p.Phe146Met	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.853	-3.416	1.563	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146N	146	F	N	missense	low	0.385278399311994	0.126464716309279	6	0.0516290042372604	0.284087410449297	0.48646938817469	0.211358756473382	0.30709126028105	0.564567902025529	0.370198529656454	NA	NA	0.489932281740557	0.36852166569499	0.539131890620736	0.518299569012174	0.523724358926788	0.587448400901722	0.515743547717461	NA	NA	0.586513275276211	0.554539422314685	NA	NA	p.Phe146Asn	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.853	-4.601	2.748	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146P	146	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe146Pro	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.853	-3.872	2.019	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146Q	146	F	Q	missense	possibly_low	0.662952283623526	0.200185390634672	6	0.0817253435024454	0.502773553734569	0.823131013512484	0.515110814340637	0.549493418594767	0.917808563743904	0.905200775053898	NA	NA	0.629320515330681	0.46077961467727	0.599092262959313	0.582998383678792	0.576134558520162	0.693143306539559	0.692938363201481	NA	NA	0.615186142239835	0.57528837133368	NA	NA	p.Phe146Gln	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.853	-4.717	2.864	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146R	146	F	R	missense	low	-0.0167549173868111	0.139219711910957	6	0.0568362093865197	-0.128151840802167	0.0946420060285448	-0.276967979516921	-0.0453861968761331	0.0707662727662591	0.119655585815716	NA	NA	0.017351102540804	0.0140517109494083	0.44360506456629	0.414286574958984	0.447514584185983	0.439695544946596	0.43276275448415	NA	NA	0.489300928640466	0.474818605833123	NA	NA	p.Phe146Arg	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.853	-3.913	2.06	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146S	146	F	S	missense	low	-0.0597911647479438	0.206138477585642	6	0.0841556810731616	-0.22473326874578	0.105150939249892	0.060910481776208	0.165806121842573	0.106349326421031	-0.189773961806807	NA	NA	-0.37219623010091	-0.129842726619758	0.446399531349541	0.486254271574885	0.49317684913294	0.45034252845085	0.330278490038597	NA	NA	0.409169065590141	0.442456534248233	NA	NA	p.Phe146Ser	1	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.853	-4.033	2.18	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146T	146	F	T	missense	low	0.195769135541569	0.481059871151893	6	0.196391870008526	-0.189151856531614	0.580690127614753	0.164900712473562	0.799171113728164	-0.0974697996921674	0.0498526924901426	NA	NA	0.710402092476518	-0.452241998226803	0.459023914345887	0.508404062790348	0.630117814803795	0.389356788029788	0.409643765901425	NA	NA	0.631865034100534	0.369948461782622	NA	NA	p.Phe146Thr	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.853	-3.23	1.377	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146V	146	F	V	missense	possibly_low	0.696440669374822	0.172173202639791	6	0.070289415641383	0.558675946223345	0.834205392526299	0.917094194489832	0.899049255371873	0.515404070171318	0.555332196813835	NA	NA	0.664343760789102	0.627420538612973	0.617578381429527	0.668620349152682	0.651712644548617	0.572737844808471	0.577060535214331	NA	NA	0.622390601553213	0.612766161305841	NA	NA	p.Phe146Val	1	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.853	-1.769	-0.084	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146W	146	F	W	missense	low	-0.232844194162961	0.227848330206822	6	0.0930186912919809	-0.415157478984293	-0.0505309093416287	-0.201992857204086	-0.233580884588907	0.157568437896066	-0.226129985059491	NA	NA	-0.532741272848245	-0.360188603173101	0.398738042027662	0.430256183781338	0.406824677734432	0.465668055041907	0.318237234347779	NA	NA	0.376144135624389	0.390651406320892	NA	NA	p.Phe146Trp	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.853	-5.497	3.644	0.007806533	NA	NA	NA	NA	NA	NA	NA
F146X	146	F	X	nonsense	low	-0.152632541400387	0.226939882616635	6	0.092647819116311	-0.334218930114538	0.0289538473137642	-0.251102660341348	-0.147878435362316	-0.0215618552886332	0.19179551602526	NA	NA	-0.483345842687306	-0.203701970747979	0.422575206031171	0.419795856125285	0.425354555937057	0.412069583838358	0.456655778733075	NA	NA	0.386305026261545	0.425845481131365	NA	NA	p.Phe146Ter	0	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F146Y	146	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe146Tyr	1	22.4	29.2	15.4	0.933	18.8	-152.6	-128.9	149.8	0.43859649122807	-5.3	0	1	14.81	0	0	0	0	8	18.7618151672993	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.853	-3.363	1.51	0.007806533	NA	NA	NA	NA	NA	NA	NA
D147A	147	D	A	missense	low	0.426902689747983	0.18633107237959	6	0.0760693417592661	0.277809519572152	0.575995859923813	0.66770770246519	0.576828381610991	0.435205681635691	0.138858872993739	NA	NA	0.415758729002296	0.327056770779989	0.559998341418308	0.615501333133006	0.582044699244668	0.548741283746263	0.439122957562679	NA	NA	0.571255399090353	0.545213906192116	NA	NA	p.Asp147Ala	1	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.725	-2.401	0.676	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147C	147	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp147Cys	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.725	-4.106	2.381	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147D	147	D	D	synonymous	wt-like	1.05518713741763	0.270137495158516	6	0.110283170588654	0.839036094962982	1.27133817987228	0.872334576771996	0.613146388112197	1.17578105464998	1.37220780876762	NA	NA	1.10726576064453	1.19038723555946	0.726440053807933	0.659086605639608	0.589897079697065	0.77033254616683	0.847612901262846	NA	NA	0.713501904494762	0.739378203121105	NA	NA	p.Asp147=	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147E	147	D	E	missense	possibly_low	0.686026248636483	0.16616561586744	6	0.0678368286117573	0.553068507732022	0.818983989540943	0.741356973547219	0.947887000649739	0.578675439005482	0.760238473699776	NA	NA	0.476739697590481	0.611259907326199	0.620160074364748	0.631188537274188	0.662271939876305	0.591669587620785	0.64492628762318	NA	NA	0.583799493771856	0.609131611455307	NA	NA	p.Asp147Glu	1	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.725	-2.861	1.136	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147F	147	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp147Phe	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.725	-4.766	3.041	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147G	147	D	G	missense	low	0.308352365180827	0.260289675341476	6	0.106262814983551	0.100081074917223	0.516623655444431	0.694861450161521	0.562172600637203	0.17353373805627	0.192112248148953	NA	NA	0.0202131387789401	0.207221015302075	0.504076165884657	0.621285047989275	0.578875946906089	0.470445112376427	0.456760681638994	NA	NA	0.489889664017819	0.518262667751496	NA	NA	p.Asp147Gly	1	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.725	-2.555	0.83	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147H	147	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp147His	1	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.725	-3.631	1.906	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147I	147	D	I	missense	low	-0.0602766958345381	0.283718609165389	6	0.115827637164555	-0.287294693091439	0.166741301422362	-0.414528695757437	-0.419493152692524	0.197958806128955	0.0301497338816432	NA	NA	0.0649169103503283	0.179336223081805	0.440435764450982	0.384986311619396	0.366628257265447	0.47775345919183	0.403118069710134	NA	NA	0.499085456675668	0.511991336786889	NA	NA	p.Asp147Ile	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.725	-3.839	2.114	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147K	147	D	K	missense	low	0.202990937798091	0.263952422734549	6	0.107758125345174	-0.00821110692000321	0.414192982516186	0.0249775870094759	0.105857303710986	-0.078839282474043	0.674595959611764	NA	NA	0.275231529165685	0.21612252976468	0.50023992029312	0.478600609192246	0.480215209081876	0.394931318294154	0.616561155304644	NA	NA	0.542348240990236	0.520264631504364	NA	NA	p.Asp147Lys	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.725	-2.993	1.268	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147L	147	D	L	missense	low	0.0734199540915122	0.156287768131593	6	0.0638042141601355	-0.0516340077242338	0.198473915907258	-0.173591439636109	-0.0516079043636536	0.0821289402412915	0.165231857365477	NA	NA	0.201551696962422	0.216806573979646	0.447013584958512	0.436305650785452	0.446169377800442	0.443095425528648	0.447857792116581	NA	NA	0.527191925623771	0.520418474058849	NA	NA	p.Asp147Leu	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.725	-3.335	1.61	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147M	147	D	M	missense	low	0.154339472063136	0.252712215427775	6	0.103169329927725	-0.0478686989043346	0.356547643030606	0.327839197181334	0.56342444026061	-0.0673526184145623	-0.105702920410673	NA	NA	0.101696036232845	0.106132697529262	0.501089432624369	0.543109759595123	0.579146609366267	0.398368300514588	0.35812314451602	NA	NA	0.506651109502353	0.495527755746385	NA	NA	p.Asp147Met	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.725	-4.039	2.314	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147N	147	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp147Asn	1	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.725	-3.163	1.438	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147P	147	D	P	missense	low	-0.0680051003239068	0.240425039844938	6	0.0981531115014019	-0.260381663837199	0.124371463189385	0.126749315986721	0.248913214914194	-0.364012051776518	-0.275059556211384	NA	NA	-0.17262466289299	0.028003138036535	0.464089126034909	0.500277862270404	0.511145580788669	0.309603347286286	0.302031570901393	NA	NA	0.450221949674326	0.477956302395493	NA	NA	p.Asp147Pro	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.725	-3.853	2.128	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147Q	147	D	Q	missense	low	0.544486279441134	0.150621664060996	6	0.0614910368597241	0.42396606182405	0.665006497058218	0.442425380237563	0.709862028495279	0.668281643765945	0.617510224344921	NA	NA	0.311520745628611	0.517317654174486	0.592828999329417	0.567516475628468	0.610808139448102	0.618481108442452	0.597654138718455	NA	NA	0.549813116963306	0.58800385994038	NA	NA	p.Asp147Gln	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.725	-2.822	1.097	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147R	147	D	R	missense	low	0.455738626323818	0.181577953876165	6	0.0741288892558705	0.310448673168354	0.601028579479282	0.362810863352742	0.165318545349578	0.4753125392591	0.485403519987935	NA	NA	0.708804207377065	0.536782082616488	0.557320871958766	0.550558681469409	0.493071429356595	0.560741857268335	0.553899886649198	NA	NA	0.631536341027239	0.592381438651831	NA	NA	p.Asp147Arg	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.725	-2.919	1.194	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147S	147	D	S	missense	low	0.392786763959846	0.299486352230935	6	0.122264791315538	0.153152176404087	0.632421351515606	0.51418879539593	0.889419758324028	0.384611946392658	0.391104197672745	NA	NA	0.0565427662499171	0.120853119723802	0.528135232514221	0.582801994777786	0.649630633951962	0.533602879106309	0.522667585922133	NA	NA	0.497362852740307	0.498838400444451	NA	NA	p.Asp147Ser	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.725	-2.601	0.876	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147T	147	D	T	missense	low	0.390718958563136	0.235836587824682	6	0.096279883808257	0.202013853863251	0.57942406326302	0.584187595517446	0.690754009366924	0.372697216018307	0.415737653549088	NA	NA	0.0299196179678967	0.251017658959152	0.530432047462103	0.597711653094987	0.606676760819637	0.530037813022209	0.530826281901997	NA	NA	0.491886336041718	0.528112597610855	NA	NA	p.Asp147Thr	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.725	-2.633	0.908	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147V	147	D	V	missense	low	0.175339745004871	0.133546188157207	6	0.0545200030131452	0.0684825026620915	0.282196987347651	0.207304759927632	0.271027003915561	0.0494269990031069	0.228981976945609	NA	NA	-0.0237133679560663	0.319011098193386	0.498390300460619	0.517436072734933	0.515926842240258	0.433310514084621	0.468972078595312	NA	NA	0.480853758680979	0.543404422541499	NA	NA	p.Asp147Val	1	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.725	-2.737	1.012	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147W	147	D	W	missense	low	0.0829891993205783	0.1585123756155	6	0.0647124063623936	-0.0438447865026338	0.20982318514379	-0.16575744904391	0.322526465948359	0.120847723248235	0.129153806359608	NA	NA	0.0483101100984963	0.0428545393126808	0.467988535391384	0.437974281144646	0.527061632057588	0.45468066630026	0.435908601910363	NA	NA	0.495669353594023	0.481296404482507	NA	NA	p.Asp147Trp	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.725	-5.928	4.203	0.007814563	NA	NA	NA	NA	NA	NA	NA
D147X	147	D	X	nonsense	low	-0.289974878275101	0.536125480365485	6	0.218872310833327	-0.718956724721478	0.139006968171275	0.0959639627628757	0.542184555475744	-0.491931069328806	-0.257309731452823	NA	NA	-0.858326889012384	-0.770430098095216	0.308539951910002	0.493720619904177	0.574554296291751	0.271328058072121	0.30791038159803	NA	NA	0.309169522221974	0.298387488062203	NA	NA	p.Asp147Ter	0	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D147Y	147	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp147Tyr	1	25.2	30.3	17.8	0.757	87.2	20.1	-79.7	-30.2	35.8288770053476	-4.5	0	1	15.32	1	83	0	0	7	20.6848095165398	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.725	-4.768	3.043	0.007814563	NA	NA	NA	NA	NA	NA	NA
M148A	148	M	A	missense	wt-like	0.95489507416406	0.112973086751903	6	0.0461210695348899	0.864499438947209	1.04529070938091	1.11235181505698	1.04775848644696	0.904862063030263	0.796121527471269	NA	NA	0.9039362697193	0.964340283259589	0.686202620078979	0.710209982138278	0.683865330548779	0.689269519290346	0.656810893990242	NA	NA	0.671675996432651	0.68853990960918	NA	NA	p.Met148Ala	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-3.753	-1.481	-2.272	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148C	148	M	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met148Cys	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-3.753	-3.398	-0.355	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148D	148	M	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met148Asp	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-3.753	-4.21	0.457	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148E	148	M	E	missense	low	0.0391751125447103	0.289752220950029	6	0.118290848860957	-0.192670690923436	0.271020916012856	0.445048621317465	0.340091761186022	-0.242701863733582	0.00595118859736075	NA	NA	-0.216789883636881	-0.0965491484621232	0.445540624407545	0.56807522275152	0.530859455623709	0.345901175559319	0.395103417802562	NA	NA	0.441136939654525	0.449944309160565	NA	NA	p.Met148Glu	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-3.753	-4.085	0.332	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148F	148	M	F	missense	possibly_wt-like	0.990268649264344	0.341254961294547	6	0.139316754560811	0.717212827882149	1.26332447064654	0.767054402985513	0.798677698367718	1.24228229185263	1.44284215448316	NA	NA	0.54089236420369	1.14986298369336	0.683463148571413	0.636662058132977	0.630011132595587	0.790230714052544	0.871007270096945	NA	NA	0.596996022831628	0.730264239009848	NA	NA	p.Met148Phe	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-3.753	-3.578	-0.175	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148G	148	M	G	missense	low	0.489206302646891	0.175095005589768	6	0.0714822367007833	0.349103693178989	0.629308912114794	0.602397798563219	0.742711809168458	0.550974356009955	0.432686699053554	NA	NA	0.299203650222654	0.307263502863508	0.565330217963397	0.601590403942545	0.617910648657	0.583381007990582	0.536439871408641	NA	NA	0.547279427936212	0.540762370997059	NA	NA	p.Met148Gly	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-3.753	-1.841	-1.912	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148H	148	M	H	missense	possibly_wt-like	0.743843353263985	0.173630044849889	6	0.0708841689831311	0.604912934982997	0.882773771544973	0.83494826417565	0.792931498806974	0.832421471203714	0.942877686745076	NA	NA	0.552937190176828	0.506944008475669	0.639946051833754	0.651123367047175	0.628768736620332	0.667594207393324	0.705417102258298	NA	NA	0.599473704654782	0.585670811697705	NA	NA	p.Met148His	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-3.753	-4.09	0.337	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148I	148	M	I	missense	possibly_wt-like	0.784287441166399	0.253729817660018	6	0.10358476429941	0.581265033792485	0.987309848540313	0.956251055332132	1.10902197845478	0.544463026149454	0.438420241668252	NA	NA	0.882497809621732	0.775070535772044	0.656619430096737	0.676960712343471	0.697111218565013	0.58143272040717	0.538338842925904	NA	NA	0.667265996402877	0.645972863790597	NA	NA	p.Met148Ile	1	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-3.753	-2.951	-0.802	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148K	148	M	K	missense	low	-0.0375395845002987	0.415680775586887	6	0.169700966012039	-0.370147366025552	0.295068197024954	0.519131355293951	0.194586988023411	0.0469612773704003	0.0593728991054811	NA	NA	-0.603268445639395	-0.44202158115564	0.422684814189331	0.583854753955999	0.499399611139274	0.432572733179019	0.412796895199643	NA	NA	0.361636338296907	0.372247048680572	NA	NA	p.Met148Lys	1	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-3.753	-4.02	0.267	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148L	148	M	L	missense	wt-like	1.13052099200293	0.0581851764211936	6	0.0237539988042906	1.08396400985772	1.17707797414815	1.04609803921353	1.12446149128501	1.07957888346388	1.19444671110372	NA	NA	1.17555491645067	1.16298591050078	0.73038246750358	0.69609800938538	0.700449422955132	0.741547413231663	0.788737737332661	NA	NA	0.727549330371794	0.733215604635367	NA	NA	p.Met148Leu	1	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-3.753	-2.325	-1.428	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148N	148	M	N	missense	low	0.218643727541857	0.206560098441762	6	0.0843278070668964	0.0533642627954979	0.383923192288216	0.245456636283876	0.530606097113778	0.274848325742517	-0.0916980818534207	NA	NA	0.0980842871685307	0.254565100795861	0.515735264929385	0.525562375466469	0.572050897320571	0.500759957029763	0.362761601280238	NA	NA	0.5059081543923	0.528910422520575	NA	NA	p.Met148Asn	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-3.753	-3.682	-0.071	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148P	148	M	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met148Pro	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-3.753	-4.367	0.614	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148Q	148	M	Q	missense	low	0.419060757184347	0.179657727360333	6	0.0733449600634785	0.2753072770124	0.562814237356293	0.761874795362091	0.39487012401746	0.363596146377852	0.405377682905088	NA	NA	0.227632468722164	0.361013325721426	0.537630027552199	0.635558808080858	0.542703182384914	0.527314636442899	0.527395019505482	NA	NA	0.532556872719483	0.552850785562542	NA	NA	p.Met148Gln	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-3.753	-4.478	0.725	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148R	148	M	R	missense	low	0.46096438020143	0.233910884123877	6	0.0954937185644637	0.273800131065277	0.648128629337583	0.605057656745329	0.868747928794312	0.283980584882118	0.396616707290904	NA	NA	0.268021305233907	0.343362098262011	0.54487302988525	0.602156950463323	0.645161141109367	0.503492465975152	0.524493350454986	NA	NA	0.54086506133978	0.548880998430721	NA	NA	p.Met148Arg	1	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-3.753	-2.829	-0.924	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148S	148	M	S	missense	low	0.566104342033334	0.131130745543497	6	0.0535339026953845	0.461179820798508	0.671028863268159	0.62207487840105	0.684894899518523	0.61688865542385	0.346324826269976	NA	NA	0.468792163909912	0.657650628676691	0.604256753797696	0.60578159774234	0.605409952311287	0.603103555284105	0.5078364847044	NA	NA	0.582164645764656	0.619564953220152	NA	NA	p.Met148Ser	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-3.753	-3.082	-0.671	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148T	148	M	T	missense	possibly_wt-like	0.737627504249009	0.140465601249511	6	0.0573448415790916	0.625233680054835	0.850021328443183	0.790936184610648	0.85878538269532	0.818480614520822	0.819138556966081	NA	NA	0.494301750107521	0.644122536593662	0.642377984814544	0.641748848241074	0.643007121388014	0.663422893919838	0.664434223292895	NA	NA	0.587412097091803	0.616522465325598	NA	NA	p.Met148Thr	1	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-3.753	-3.441	-0.312	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148V	148	M	V	missense	wt-like	1.30643581185169	0.245118103096976	2	0.173324672891455	0.966725695352251	1.64614592835112	1.47976048474314	1.13311113896023	NA	NA	NA	NA	NA	NA	0.745393577700243	0.788467576815453	0.702319578585034	NA	NA	NA	NA	NA	NA	NA	NA	p.Met148Val	1	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-3.753	-2.645	-1.108	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148W	148	M	W	missense	possibly_wt-like	0.902087105979393	0.239886166313675	6	0.0979331173034876	0.710141723170821	1.09403248878797	1.23379374759689	1.1032004961664	0.721628688120523	0.644514880060838	NA	NA	0.984788080524888	0.724596743406814	0.661464428756918	0.736076964378081	0.695852545578001	0.634443344476338	0.606598185267711	NA	NA	0.688307624191229	0.634621233322607	NA	NA	p.Met148Trp	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-3.753	-4.215	0.462	0.006267448	NA	NA	NA	NA	NA	NA	NA
M148X	148	M	X	nonsense	low	-0.0695765050522173	0.108362287331768	6	0.0442387185539482	-0.15628280014016	0.0171297900357251	0.0441024265752727	-0.00342801142778438	-0.266165540721065	-0.0807108466170194	NA	NA	-0.0220644910270121	-0.0891925670956955	0.454092626443464	0.482674176493432	0.456586437709159	0.338880491380311	0.366400616138853	NA	NA	0.481192941032376	0.451598815177769	NA	NA	p.Met148Ter	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M148Y	148	M	Y	missense	wt-like	1.09460167954016	0.0664009820176231	6	0.0271080873938163	1.04147080455851	1.1477325545218	1.20232859681658	1.06468406264388	1.01355982295425	1.12796389974254	NA	NA	1.10609415327769	1.05297954180602	0.717527209380374	0.729374925968574	0.687524839329082	0.721793519846571	0.766718372753635	NA	NA	0.713260898914177	0.708475009803254	NA	NA	p.Met148Tyr	0	26.2	26.8	18.7	0.986	60.3	-158.5	-145.1	145.1	0	-4.8	0	1	16.02	0	0	0	0	8	17.9333974677287	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-3.753	-4.558	0.805	0.006267448	NA	NA	NA	NA	NA	NA	NA
I149A	149	I	A	missense	possibly_low	0.669665887593684	0.188019233877361	6	0.076758530804758	0.51922193171015	0.820109843477217	0.884417814346264	0.88568904152526	0.632740863645134	0.681663237230908	NA	NA	0.474101397645182	0.459382971169353	0.613374319417043	0.661660320378791	0.648824009071185	0.607846773813787	0.618901865020298	NA	NA	0.583256782085272	0.574974264145485	NA	NA	p.Ile149Ala	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.632	-2.622	0.99	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149C	149	I	C	missense	wt-like	0.967718994815914	0.145970607908248	6	0.0595922511365132	0.850920328830682	1.08451766080115	1.17528722644319	1.02811190129257	0.842156858400483	1.07528947650672	NA	NA	0.867488929341928	0.817979576910587	0.67506234445446	0.723615147343852	0.679617507606803	0.670507181302116	0.749272399795028	NA	NA	0.664178593567992	0.65562317053228	NA	NA	p.Ile149Cys	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.632	-3.784	2.152	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149D	149	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile149Asp	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.632	-4.42	2.788	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149E	149	I	E	missense	low	-0.106899388631617	0.242986798067053	6	0.0991989449161623	-0.301325747971668	0.0875269707084333	0.069264403530016	0.0755566175524513	0.144269990740811	-0.143701554971894	NA	NA	-0.427242045915928	-0.359543742725161	0.429767411044325	0.48803364663191	0.473663844108756	0.461688960137128	0.345537849598765	NA	NA	0.397845861951523	0.390796436388288	NA	NA	p.Ile149Glu	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.632	-4.275	2.643	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149F	149	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile149Phe	1	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.632	-2.278	0.646	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149G	149	I	G	missense	low	-0.00692889243841468	0.242934817428609	6	0.0991777239093802	-0.201313659369457	0.187455874492628	0.286018855326538	0.293614405439661	-0.0894666491387636	-0.0479249481906925	NA	NA	-0.244982601959962	-0.238832416107268	0.426641073252804	0.534202078225141	0.520810504293472	0.391751450746227	0.377259432661791	NA	NA	0.435337554433835	0.417944592071773	NA	NA	p.Ile149Gly	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.632	-4.093	2.461	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149H	149	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile149His	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.632	-5.306	3.674	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149K	149	I	K	missense	low	-0.128046807219842	0.15048886618115	6	0.0614368223522994	-0.248460766354934	-0.00763284808474951	-0.185736331338977	0.0694151516384634	-0.0301133369508893	-0.0727253984098851	NA	NA	-0.362114052404379	-0.187006875853382	0.42042162667018	0.433718803792721	0.472335986895821	0.409510852227566	0.369045427508886	NA	NA	0.411243020703499	0.429600232636862	NA	NA	p.Ile149Lys	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.632	-4.254	2.622	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149L	149	I	L	missense	wt-like	0.936105970848709	0.207499735472293	6	0.0847114122782675	0.77007465370378	1.10213728799364	0.664629344585086	0.730966738992546	0.948123859741175	1.09084689833677	NA	NA	0.973978606346553	1.20809037709012	0.694149079210873	0.614845646691371	0.615371226250698	0.702214097920788	0.75442507815161	NA	NA	0.686084060500958	0.743359665804242	NA	NA	p.Ile149Leu	1	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.632	-2.133	0.501	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149M	149	I	M	missense	wt-like	0.921985920093591	0.178277093343849	6	0.0727813185864927	0.77933715691673	1.06463468327045	0.60350914834817	1.13360050291461	1.00383162045325	0.879895746033897	NA	NA	0.92404742113411	0.987031081677504	0.689100171645146	0.601827120079618	0.702425384831568	0.718882695706545	0.684557239595755	NA	NA	0.675812962331062	0.693643103694538	NA	NA	p.Ile149Met	1	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.632	-3.643	2.011	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149N	149	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile149Asn	1	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.632	-4.577	2.945	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149P	149	I	P	missense	low	-0.186452462573478	0.409385180744639	6	0.167130800180239	-0.514022811634106	0.14111788648715	0.149336483552735	0.373483379145898	-0.209035392866772	-0.172460340189819	NA	NA	-0.723533222853989	-0.536505682228923	0.353486061753316	0.505088901176472	0.538079116431176	0.355974688739021	0.336012828565537	NA	NA	0.336897263350137	0.35099743476761	NA	NA	p.Ile149Pro	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.632	-4.515	2.883	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149Q	149	I	Q	missense	low	0.203147853210054	0.0688640277972162	6	0.0281136216226695	0.148046167354635	0.258249539065473	0.189870632373854	0.0920399700296332	0.244332741381944	0.225385241689697	NA	NA	0.173875205507563	0.293383328277634	0.502675930688902	0.513722625012485	0.477227738916075	0.491629236365318	0.467780825950114	NA	NA	0.521498730889425	0.537640699227482	NA	NA	p.Ile149Gln	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.632	-4.682	3.05	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149R	149	I	R	missense	low	-0.017654994935389	0.0917205421072305	6	0.0374447545156956	-0.0910453651960959	0.0557353753253179	0.035812306028227	0.0538313264408999	-0.00309608058312052	0.045709427430073	NA	NA	-0.187239276018342	-0.0509476729100714	0.453707898986587	0.480908391014963	0.468966580473393	0.417594820671327	0.408271500468642	NA	NA	0.447215649593788	0.460200148379386	NA	NA	p.Ile149Arg	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.632	-4.568	2.936	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149S	149	I	S	missense	low	0.478734269477305	0.26016683987747	6	0.106212667615363	0.270561266249271	0.686907272705339	0.919959178559973	0.637323002331083	0.255872590114159	0.254426377779752	NA	NA	0.461457351038411	0.343367117040453	0.564768982349245	0.669230587235276	0.595124348239221	0.495082132237761	0.477399362685602	NA	NA	0.580655837537084	0.548882127161407	NA	NA	p.Ile149Ser	1	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.632	-4.015	2.383	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149T	149	I	T	missense	possibly_low	0.660622320310331	0.146885464145051	6	0.059965739631208	0.543091630326858	0.778153010293805	0.759702688979972	0.873014281146362	0.711689499432144	0.60575262372244	NA	NA	0.506269536552503	0.507305292028567	0.612614682982172	0.635096152093472	0.646083576700956	0.631469390103632	0.593759975860713	NA	NA	0.589873931493085	0.585752064902477	NA	NA	p.Ile149Thr	1	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.632	-3.01	1.378	0.007348573	NA	NA	NA	NA	2.44e-05	NA	NA
I149V	149	I	V	missense	wt-like	0.830327870083051	0.0665078072809791	6	0.0271516986249598	0.777111518659044	0.883544221507058	0.852500384724619	0.843961448920138	0.705719060701703	0.906648368253198	NA	NA	0.834462966954609	0.838674990944038	0.65612346632492	0.654861947132451	0.63980201243469	0.629682945261295	0.693417811674927	NA	NA	0.657384985517388	0.660277599721786	NA	NA	p.Ile149Val	1	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.632	-1.534	-0.098	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149W	149	I	W	missense	low	-0.000414724452642759	0.132334255116234	6	0.0540252334210114	-0.106302236214195	0.105472787308909	-0.0373990635130672	0.217183855073811	-0.0815949858323353	0.0988574736134463	NA	NA	-0.0633156822793178	-0.136219943778393	0.453168374025727	0.465314459363275	0.504285319750678	0.394106770505675	0.425874339181595	NA	NA	0.472707361665997	0.441022288688178	NA	NA	p.Ile149Trp	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.632	-3.857	2.225	0.007348573	NA	NA	NA	NA	NA	NA	NA
I149X	149	I	X	nonsense	low	-0.0957144988457638	0.149441481620298	6	0.0610092293958733	-0.215290391186218	0.0238613934946902	-0.144983205580642	0.016408456765668	0.0595488296662063	0.0250885992190172	NA	NA	-0.281470813045935	-0.248878860098897	0.432085430966676	0.442399169446988	0.460875315599021	0.436339117676331	0.401441802310513	NA	NA	0.427831744257022	0.41568513197642	NA	NA	p.Ile149Ter	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I149Y	149	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile149Tyr	0	25.9	23.2	17.3	0.993	5.1	-159.2	-123.7	136	0	-5.6	0	1	13.89	0	0	0	0	7	14.2602696394592	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.632	-4.27	2.638	0.007348573	NA	NA	NA	NA	NA	NA	NA
W150A	150	W	A	missense	low	0.53976338984943	0.0981400394581766	6	0.0400655033348567	0.461236446290642	0.618290333408219	0.59815117115647	0.695330674463268	0.5502825800415	0.466880883222091	NA	NA	0.421338409524019	0.506596620689233	0.58438335095674	0.600685877528875	0.607666289678786	0.583174018242141	0.547765117623018	NA	NA	0.572403167687302	0.585592683671339	NA	NA	p.Trp150Ala	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	148	-0.9	1.8	-2.7	264	121	143	5.4	8.1	-2.7	204	89	115	5.89	6	0.11	-1.487	-3.739	2.252	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150C	150	W	C	missense	wt-like	1.24950668846881	0.497925906900301	6	0.203277400269717	0.851090305069231	1.64792307186838	0.542707514679453	0.954760384710725	1.19880941444774	1.17068238745775	NA	NA	1.86388059469933	1.76619983481785	0.779044939112431	0.588876446903013	0.663758046406973	0.777222976911633	0.780866901313229	NA	NA	0.869141415239628	0.868879307343595	NA	NA	p.Trp150Cys	1	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	215	-0.9	2.5	-3.4	264	148	116	5.4	5.5	-0.0999999999999996	204	121	83	5.89	5.07	-0.82	-1.487	-5.234	3.747	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150D	150	W	D	missense	low	0.0331799741872222	0.122797068284657	6	0.0501316932011855	-0.0650763389711129	0.131436287345557	0.0118568650524257	-0.0160894060597397	0.204170745188415	0.159838372156383	NA	NA	-0.107328836941391	-0.0533678942727598	0.461654734715196	0.475805911555786	0.453848895170728	0.479612164555826	0.446071448928935	NA	NA	0.463653632410872	0.459655837019519	NA	NA	p.Trp150Asp	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	181	-0.9	-3.5	2.6	264	187	77	5.4	13	-7.6	204	133	71	5.89	5.05	-0.84	-1.487	-4.385	2.898	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150E	150	W	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp150Glu	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	152	-0.9	-3.5	2.6	264	214	50	5.4	12.3	-6.9	204	147	57	5.89	3.22	-2.67	-1.487	-4.165	2.678	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150F	150	W	F	missense	wt-like	1.05556115481517	0.38183165584172	6	0.155882120742368	0.750037812326403	1.36108449730394	0.576991414276248	0.595094171786448	1.07948009885954	1.29363113874735	NA	NA	1.42121378372776	1.36695632149367	0.759800230671204	0.59617887534296	0.585993978060855	0.741517855395983	0.821588003862185	NA	NA	0.778082605946424	0.779088851393626	NA	NA	p.Trp150Phe	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	40	-0.9	2.8	-3.7	264	228	36	5.4	5.2	0.2	204	165	39	5.89	3.32	-2.57	-1.487	-2.118	0.631	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150G	150	W	G	missense	low	-0.0475529699986668	0.152161758954537	6	0.0621197779671642	-0.169305497541933	0.0741995575445998	-0.0749005717552565	0.0327394675268096	-0.0271183928693565	0.106221504632737	NA	NA	-0.33245946797778	0.0101996404508457	0.442820009506274	0.457326684239986	0.464406272334337	0.410406984429755	0.428313334772562	NA	NA	0.417343119199802	0.473952269487323	NA	NA	p.Trp150Gly	1	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	184	-0.9	-9.4	8.5	264	97	167	5.4	9	-3.6	204	75	129	5.89	3.29	-2.6	-1.487	-3.888	2.401	0.005076728	NA	NA	NA	NA	4.06e-06	NA	NA
W150H	150	W	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp150His	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	115	-0.9	-3.2	2.3	264	216	48	5.4	10.4	-5	204	155	49	5.89	7.59	1.7	-1.487	-4.556	3.069	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150I	150	W	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp150Ile	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	61	-0.9	4.5	-5.4	264	191	73	5.4	5.2	0.2	204	131	73	5.89	6.02	0.13	-1.487	-3.97	2.483	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150K	150	W	K	missense	low	-0.108970394370818	0.312009931841765	6	0.127377521282147	-0.35862574852381	0.140684959782175	0.189984486662708	0.265148641822484	-0.132741029979622	-0.0470122106167759	NA	NA	-0.470151712187576	-0.459050541926122	0.383911116306588	0.513746875835954	0.514655871170019	0.378803106755306	0.37756173488087	NA	NA	0.38901912585787	0.368417210246368	NA	NA	p.Trp150Lys	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	110	-0.9	-3.9	3	264	230	34	5.4	11.3	-5.9	204	146	58	5.89	9.74	3.85	-1.487	-4.176	2.689	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150L	150	W	L	missense	possibly_wt-like	0.741335471887457	0.170991632969142	6	0.0698070418432766	0.604516184007355	0.87815475976756	0.433523949833252	0.708283930455872	0.816098596503206	0.759803189709829	NA	NA	0.948094078673948	0.782209086148638	0.646180227098076	0.565620481902401	0.610466936078468	0.662710158391672	0.644782119880063	NA	NA	0.680759481809794	0.64757833431609	NA	NA	p.Trp150Leu	1	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	61	-0.9	3.8	-4.7	264	191	73	5.4	4.9	0.5	204	131	73	5.89	9.71	3.82	-1.487	-3.093	1.606	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150M	150	W	M	missense	wt-like	0.852905457530677	0.101734294285851	6	0.0415328517237463	0.771502563976892	0.934308351084462	0.666280939712372	0.879777114446082	0.826672793507085	0.879625924235978	NA	NA	0.900028594267044	0.965047379015501	0.668373142271158	0.615197434421781	0.647545780855906	0.665874116779373	0.684467873571393	NA	NA	0.670872167762944	0.688698936489278	NA	NA	p.Trp150Met	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	67	-0.9	1.9	-2.8	264	203	61	5.4	5.7	-0.3	204	149	55	5.89	5.74	-0.15	-1.487	-4.788	3.301	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150N	150	W	N	missense	low	-0.259421958827593	0.344943262205274	6	0.140822497102331	-0.535428981361158	0.0165850637059722	0.113319954232615	0.218744614032319	-0.391480199090892	-0.35654499780243	NA	NA	-0.630305734886873	-0.510265389450298	0.356486773039283	0.497417424736843	0.504622774206949	0.301384465506607	0.27504327709221	NA	NA	0.356074630700198	0.356898915378368	NA	NA	p.Trp150Asn	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	174	-0.9	-3.5	2.6	264	187	77	5.4	11.6	-6.2	204	132	72	5.89	5.47	-0.42	-1.487	-4.471	2.984	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150P	150	W	P	missense	low	0.187269187719531	0.103505897081897	6	0.0422561055366129	0.104448742740847	0.270089632698216	0.0827389763757432	0.0573392214546773	0.27260340367574	0.319681441387492	NA	NA	0.215680780364932	0.175571303058604	0.499550167560569	0.49090371407237	0.469725028661741	0.500088242666932	0.499012092454206	NA	NA	0.53009834977654	0.511144600711746	NA	NA	p.Trp150Pro	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	147	-0.9	-1.6	0.7	264	154	110	5.4	8	-2.6	204	115	89	5.89	6.3	0.41	-1.487	-4.591	3.104	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150Q	150	W	Q	missense	low	0.211004338952305	0.127142431650139	6	0.051905680366588	0.109271074840745	0.312737603063865	0.139389535612709	-0.0185260324278227	0.2752844845846	0.297423248984532	NA	NA	0.279301516469989	0.293153280489822	0.501930337900209	0.502970213501436	0.453322067871937	0.500890462298983	0.491640092934988	NA	NA	0.543185458031547	0.537588961140154	NA	NA	p.Trp150Gln	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	130	-0.9	-3.5	2.6	264	214	50	5.4	10.5	-5.1	204	146	58	5.89	6.24	0.35	-1.487	-4.435	2.948	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150R	150	W	R	missense	low	-0.117649856301063	0.0647765176806385	6	0.0264449026053229	-0.169480912982165	-0.0658187996199603	-0.14801895401464	-0.0138845511338679	-0.132427425157317	-0.102454956925486	NA	NA	-0.0992529868023659	-0.209860263772699	0.433106515348701	0.441752558764957	0.454325610755867	0.378896942023137	0.359198882600127	NA	NA	0.465314875764708	0.424460471932445	NA	NA	p.Trp150Arg	1	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	101	-0.9	-4.5	3.6	264	265	-1	5.4	10.5	-5.1	204	174	30	5.89	6.34	0.45	-1.487	-4.433	2.946	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150S	150	W	S	missense	low	0.12053707325713	0.101933982314042	6	0.0416143740198813	0.0389743989389837	0.202099747575277	0.0208410850375006	0.0483408937214035	0.291355705186453	0.125359219207182	NA	NA	0.180273729884799	0.0570518065054444	0.481104465104264	0.477719539360712	0.467779484299479	0.505699212618764	0.434651819950854	NA	NA	0.522814939822609	0.484489390847815	NA	NA	p.Trp150Ser	1	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	177	-0.9	-0.8	-0.1	264	143	121	5.4	9.2	-3.8	204	105	99	5.89	5.68	-0.21	-1.487	-4.071	2.584	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150T	150	W	T	missense	low	-0.181713203403301	0.472991812379101	6	0.193098098807172	-0.560178522548515	0.196752115741913	0.0520888099984435	0.628871314620221	-0.305001908461503	-0.232980969833406	NA	NA	-0.689993672454389	-0.543262794289174	0.346637134671995	0.484375266338157	0.593296993883515	0.32726006749232	0.315968161660064	NA	NA	0.343796519061027	0.349477750282963	NA	NA	p.Trp150Thr	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	128	-0.9	-0.7	-0.2	264	163	101	5.4	8.6	-3.2	204	119	85	5.89	5.6	-0.29	-1.487	-4.01	2.523	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150V	150	W	V	missense	possibly_wt-like	0.727470330612386	0.322280627583271	5	0.144128278221498	0.444984096144482	1.00995656508029	0.317355133497527	0.490626414036651	0.846620654404042	0.854112500366009	NA	NA	NA	1.1286369507577	0.671842816036486	0.540876666927392	0.563406819296149	0.671842816036486	0.676017728784344	NA	NA	NA	0.72549047284535	NA	NA	p.Trp150Val	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	88	-0.9	4.2	-5.1	264	165	99	5.4	5.9	-0.5	204	117	87	5.89	5.61	-0.28	-1.487	-3.266	1.779	0.005076728	NA	NA	NA	NA	NA	NA	NA
W150X	150	W	X	nonsense	low	0.198836100004041	0.503908181500946	6	0.205719653648515	-0.204367012059103	0.602039212067185	-0.378442680455564	-0.445279917199468	0.204295783475582	0.596092781455306	NA	NA	0.488757613095814	0.727593019652578	0.532960608931259	0.39267258848766	0.361052855280258	0.47964957788729	0.590560598693879	NA	NA	0.586271639975228	0.635295100276685	NA	NA	p.Trp150Ter	1	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	NA	-0.9	NA	NA	264	NA	NA	5.4	NA	NA	204	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
W150Y	150	W	Y	missense	possibly_wt-like	0.997016926746312	0.35219750519213	6	0.143784029400325	0.715205407569627	1.278828445923	1.15519256587014	0.936919986137649	0.383567625847052	1.03173375910599	NA	NA	1.45931780988986	1.01536981362718	0.709675767868017	0.719335009361141	0.659900742261892	0.533290402731176	0.734846577521397	NA	NA	0.785920797483718	0.700016526374894	NA	NA	p.Trp150Tyr	0	26.2	20	19.3	0.973	17.3	-178.3	-110	116.9	2.27272727272727	-3.7	0	1	11.94	0	0	0	0	5	12.4169422091933	37	-0.9	-1.3	0.4	264	255	9	5.4	6.2	-0.8	204	181	23	5.89	5.66	-0.23	-1.487	-1.251	-0.236	0.005076728	NA	NA	NA	NA	NA	NA	NA
D151A	151	D	A	missense	low	0.0994047028093351	0.123198745274483	6	0.0502956771456007	0.000826987025903447	0.197982418592767	0.175931904750141	0.186727436685675	-0.0488594348165373	0.165224489866135	NA	NA	-0.0693216192313116	0.186725439601909	0.484586096797479	0.510753693175292	0.49770028363662	0.403901738499411	0.447855351972268	NA	NA	0.471471909958339	0.513653182498367	NA	NA	p.Asp151Ala	1	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-0.578	-3.562	2.984	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151C	151	D	C	missense	low	0.00397606861583654	0.0857125293353285	6	0.0349919935724816	-0.0646069785334844	0.0725591157651575	0.0470990193619805	-0.0404294652100058	-0.0533653238540764	-0.0654730687577281	NA	NA	0.159087234630934	-0.0230619844760845	0.457528984407258	0.483312447070757	0.448586287910734	0.402553508897755	0.371447427174492	NA	NA	0.51845677023976	0.466471680903782	NA	NA	p.Asp151Cys	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-0.578	-5.369	4.791	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151E	151	D	E	missense	low	0.402277255341637	0.277905817775575	6	0.11345457501684	0.179910374427332	0.624644136255941	0.0188672046253942	0.23490272070952	0.274004924054811	0.633567875502929	NA	NA	0.769241230135953	0.483079577021214	0.544210006426466	0.477299105261093	0.508116347044312	0.500507598591289	0.602972494965607	NA	NA	0.643968543291448	0.580303665808619	NA	NA	p.Asp151Glu	1	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-0.578	-3.084	2.506	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151F	151	D	F	missense	low	0.324594387818563	0.1567714737948	6	0.0640016861702276	0.199153387975082	0.450035387662045	0.354408801718452	0.0838616467765008	0.387108915296436	0.546114339955467	NA	NA	0.352817411744402	0.223255211420123	0.541559531170639	0.548769052677061	0.475459489173508	0.534350009664217	0.574007545326478	NA	NA	0.558308050739862	0.5218687821458	NA	NA	p.Asp151Phe	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-0.578	-4.573	3.995	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151G	151	D	G	missense	low	-0.0610794807944721	0.1007037260834	6	0.0411121240168892	-0.141657763195519	0.019498801606575	-0.112120887631714	-0.0593961246681792	0.0233365604621249	0.0916088854632089	NA	NA	-0.150830106752993	-0.159075211639281	0.440183789044414	0.44939880274469	0.444485472906703	0.425503863439635	0.423473578715914	NA	NA	0.454705200467007	0.435882105182125	NA	NA	p.Asp151Gly	1	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-0.578	-2.857	2.279	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151H	151	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp151His	1	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-0.578	-4.722	4.144	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151I	151	D	I	missense	low	-0.273233151630269	0.171188791804374	6	0.0698875316007099	-0.410210196536066	-0.136256106724473	-0.42072954510233	-0.155854661489226	-0.21909262412461	-0.0777067754687808	NA	NA	-0.231791789709699	-0.53422351388697	0.375530557236681	0.383665538336879	0.423630001971773	0.352965414258546	0.367395576136484	NA	NA	0.438050971449407	0.351510697799168	NA	NA	p.Asp151Ile	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-0.578	-4.3	3.722	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151K	151	D	K	missense	low	-0.199864246444973	0.201821473017072	6	0.0823932713381182	-0.361352090836121	-0.0383764020538252	0.0162621516264519	-0.00738040610965757	-0.247892457491629	-0.0977624372616088	NA	NA	-0.423167777869733	-0.439244551563663	0.385777783150742	0.476744232176912	0.455731883461005	0.344348072032697	0.360753063284692	NA	NA	0.398683959563164	0.37287160673832	NA	NA	p.Asp151Lys	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-0.578	-3.736	3.158	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151L	151	D	L	missense	low	-0.0213944754808904	0.0674666352491239	6	0.0275431385038038	-0.0753780349695443	0.0325890840077636	-0.141334883853628	-0.00526166053209061	-0.0340657308801834	0.020453364738727	NA	NA	-0.0254073446854482	0.0572494023272813	0.449683119339224	0.443176257486877	0.456189981191571	0.408328236666356	0.39990659470059	NA	NA	0.4805052990718	0.484533830440055	NA	NA	p.Asp151Leu	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-0.578	-4.08	3.502	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151M	151	D	M	missense	low	-0.00400985352380179	0.267447347040799	6	0.109184922218502	-0.218008368726872	0.209988661679269	0.266901827833807	0.392713082023149	-0.165591557812951	-0.2388695078091	NA	NA	-0.0732077083893132	-0.206005256988403	0.44799999517607	0.530130174885907	0.542236804518316	0.368973735972774	0.314017855079017	NA	NA	0.470672521698898	0.425327468653243	NA	NA	p.Asp151Met	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-0.578	-5.201	4.623	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151N	151	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp151Asn	1	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-0.578	-2.964	2.386	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151P	151	D	P	missense	low	0.150507231123775	0.149244882159759	6	0.0609289680022025	0.0310886482242644	0.269925814023285	-0.0683427685176494	0.0452880184928329	0.212942476904799	0.154657704346608	NA	NA	0.366826110070318	0.191671845445739	0.474678107515644	0.458723488262547	0.467119416744074	0.482236798287213	0.444355591688083	NA	NA	0.561189711071492	0.514765636479981	NA	NA	p.Asp151Pro	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-0.578	-3.952	3.374	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151Q	151	D	Q	missense	low	-0.357434127898957	0.138148289792733	6	0.0563988031383897	-0.467973750821366	-0.246894504976549	-0.353343186923559	-0.239338040294276	-0.30366897418198	-0.249625393694627	NA	NA	-0.614830352099335	-0.383798820199966	0.372299714550138	0.398018749733958	0.40557991291176	0.327658901426698	0.310455464021317	NA	NA	0.359257995468153	0.385341433632122	NA	NA	p.Asp151Gln	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-0.578	-3.97	3.392	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151R	151	D	R	missense	low	0.0198079758787625	0.185972308165645	6	0.0759228768822432	-0.128998128413103	0.168614080170628	0.0815118446060371	0.338473218206452	-0.0389297246980301	-0.00463645760820193	NA	NA	-0.0303835423762088	-0.227187482857473	0.450022612359121	0.490642336514973	0.530509507581993	0.406872856741804	0.391596748378378	NA	NA	0.479481669955504	0.420563554762738	NA	NA	p.Asp151Arg	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-0.578	-4.192	3.614	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151S	151	D	S	missense	low	0.157949378242776	0.328202555987824	6	0.1339881324079	-0.104662535632491	0.420561292118043	0.227911523253434	0.537084889438137	0.263827804229436	0.399976716823616	NA	NA	-0.204835031514155	-0.27626963277381	0.509643869813373	0.52182528797402	0.573451688473611	0.497462451652725	0.525606198623934	NA	NA	0.443596113400084	0.409524906737381	NA	NA	p.Asp151Ser	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-0.578	-3.432	2.854	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151T	151	D	T	missense	low	-0.175417643884223	0.05982803254594	6	0.0244246920086964	-0.223289160554751	-0.127546127213695	-0.227505092928085	-0.252694461932321	-0.134051469561637	-0.200993701767187	NA	NA	-0.104535898059332	-0.132725239056774	0.413757103155166	0.424822108955878	0.402692097354453	0.378411003571908	0.32656246871502	NA	NA	0.464228154111451	0.441808252942806	NA	NA	p.Asp151Thr	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-0.578	-3.701	3.123	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151V	151	D	V	missense	low	0.027815591396715	0.154319065149978	6	0.0630004945334599	-0.095663108897079	0.151294291690509	0.217636028646095	0.222009256917866	0.00228506216970525	-0.0593278728842954	NA	NA	-0.0962275014446639	-0.119481425024417	0.455362019869582	0.519636620263006	0.505328628422204	0.419204939315984	0.373482739845184	NA	NA	0.465937233455364	0.4447868062838	NA	NA	p.Asp151Val	1	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-0.578	-4.035	3.457	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151W	151	D	W	missense	low	-0.0567354289425502	0.140449224228223	6	0.057338155688148	-0.169116149031271	0.0556452911461703	-0.18169089010763	-0.223023458654029	-0.0411428736920926	0.0115637790016012	NA	NA	-0.0733904999435015	0.167271369740351	0.421843897638147	0.434580477798518	0.409107317477776	0.406210649359019	0.396962329479331	NA	NA	0.47063492054864	0.509277933446961	NA	NA	p.Asp151Trp	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-0.578	-5.807	5.229	0.001593451	NA	NA	NA	NA	NA	NA	NA
D151X	151	D	X	nonsense	low	-0.0320002852507879	0.188433226614529	6	0.0769275426319711	-0.182775498228621	0.118774927727045	0.173839811421716	0.116281386771178	0.0308880621661586	0.00765960783359196	NA	NA	-0.301421813164086	-0.219248766533285	0.425745554168643	0.510308079869916	0.482469018526326	0.427763386044278	0.395669252869494	NA	NA	0.423727722293008	0.422348983791932	NA	NA	p.Asp151Ter	0	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D151Y	151	D	Y	missense	low	0.0339910272448048	0.202806920585613	6	0.0827955786233169	-0.128285324936051	0.19626737942566	-0.235493333920986	0.0212817938441937	0.290817448684053	0.200766680094739	NA	NA	-0.157331995272862	0.0839055700396904	0.46077802572317	0.423120623451086	0.461928988432415	0.505538158197811	0.459627063013924	NA	NA	0.453367729005171	0.490528841937794	NA	NA	p.Asp151Tyr	1	27.1	17.2	16.9	0.926	18.3	142.6	-122.4	100.4	0	-6.3	0	1	11.15	2	29	0	0	5	10.088237038934	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-0.578	-4.659	4.081	0.001593451	NA	NA	NA	NA	4.06e-06	NA	NA
R152A	152	R	A	missense	wt-like	0.964577411503076	0.0886451473464589	6	0.0361892298621091	0.893647824345101	1.03550699866105	0.855174364471932	0.850007673282079	1.0313007259944	1.03519067690117	NA	NA	0.985496751518448	1.03029427685043	0.695913230806222	0.655431501529245	0.641109277303122	0.72710186420205	0.735991522082154	NA	NA	0.688453401410697	0.703373060201747	NA	NA	p.Arg152Ala	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-0.813	-3.352	2.539	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152C	152	R	C	missense	wt-like	1.14494933231268	0.165371085079296	6	0.0675124627757767	1.01262733676455	1.2772713278608	1.16850465328913	0.868598418138098	1.26611997825088	1.32430240304334	NA	NA	1.04419423830607	1.19797630284855	0.731627731585677	0.722170467605586	0.645128815145819	0.797363307458499	0.831746445372186	NA	NA	0.700527772298484	0.741084995565767	NA	NA	p.Arg152Cys	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-0.813	-2.918	2.105	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152D	152	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg152Asp	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-0.813	-3.993	3.18	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152E	152	R	E	missense	low	0.503567849084517	0.262510717782083	6	0.107169551762977	0.293519387389781	0.713616310779252	0.826052009702708	0.797344363992709	0.211062913471923	0.250258800777202	NA	NA	0.436307566006748	0.500381440555811	0.579838639806593	0.649228475788123	0.629722850010955	0.481674404709102	0.47601904504332	NA	NA	0.575482399135553	0.584194880477633	NA	NA	p.Arg152Glu	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-0.813	-3.595	2.782	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152F	152	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg152Phe	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-0.813	-3.5	2.687	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152G	152	R	G	missense	possibly_wt-like	0.800460141034737	0.101435806992608	6	0.0414109947965547	0.719296082669515	0.88162419939996	0.901479119039636	0.929287093569195	0.768483309614875	0.811940311373914	NA	NA	0.667705026300346	0.723865986310459	0.653356685618892	0.665294357290599	0.65825042105283	0.648462950184954	0.6620501364774	NA	NA	0.623082030925342	0.634456884972087	NA	NA	p.Arg152Gly	1	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-0.813	-3.679	2.866	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152H	152	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg152His	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-0.813	-4.629	3.816	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152I	152	R	I	missense	wt-like	1.01433184598336	0.0891248991482812	3	0.0514562845147584	0.913479381556188	1.11518431041053	1.06939518148663	0.911505626897435	1.06209472956602	NA	NA	NA	NA	NA	0.701060272030685	0.701060272030685	0.654405858678415	0.736315892071551	NA	NA	NA	NA	NA	NA	NA	p.Arg152Ile	1	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-0.813	-4.222	3.409	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152K	152	R	K	missense	wt-like	1.0363237732903	0.106292513932936	6	0.0433937371022273	0.951273611415339	1.12137393516527	1.06878841353509	1.14805467117698	1.12771192201441	0.981080032170172	NA	NA	0.858724304518652	1.03358329632651	0.704831655834919	0.700931031203421	0.705550546129044	0.755949540503514	0.718069867002543	NA	NA	0.662375665766476	0.704112765540794	NA	NA	p.Arg152Lys	1	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-0.813	-2.677	1.864	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152L	152	R	L	missense	low	0.568247963376272	0.183688255394732	6	0.0749904162431889	0.421269448353955	0.71522647839859	0.444687816736267	0.92979687919539	0.538033815990894	0.566243625660162	NA	NA	0.447550880040615	0.483174762634307	0.579917038732118	0.567998371819567	0.658360642705164	0.579509004270615	0.580674442702991	NA	NA	0.577795205885593	0.580325073193621	NA	NA	p.Arg152Leu	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-0.813	-3.625	2.812	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152M	152	R	M	missense	possibly_wt-like	0.77640028056739	0.163677855555543	6	0.0668212047173415	0.645433125917823	0.907367435216957	1.04378763251662	0.901117711715392	0.690267660731827	0.723985741674605	NA	NA	0.601715717909493	0.697527218856403	0.630726249824131	0.695605895601075	0.6521598691549	0.62505965457374	0.632919242386913	NA	NA	0.609507695332021	0.628533257261348	NA	NA	p.Arg152Met	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-0.813	-4.787	3.974	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152N	152	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg152Asn	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-0.813	-3.816	3.003	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152P	152	R	P	missense	possibly_low	0.627045153347171	0.169138872608418	6	0.069050655593372	0.491708355275283	0.762381951419059	0.662751039988793	0.780885555607572	0.795377291215626	0.674899741402713	NA	NA	0.474985149112846	0.373372142755475	0.615553669566578	0.614445570122948	0.62616426192521	0.656510032968938	0.616661769010208	NA	NA	0.583438574246694	0.555630301771209	NA	NA	p.Arg152Pro	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-0.813	-4.195	3.382	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152Q	152	R	Q	missense	possibly_wt-like	0.74049915500267	0.218382875951327	6	0.089154435773711	0.565759671824207	0.915238638181133	0.6214235736139	0.769583117430524	0.527839502136856	0.948048288438425	NA	NA	1.04359625965955	0.532504188736761	0.614681706195261	0.605642870623876	0.623720541766645	0.576458712620714	0.707129625562408	NA	NA	0.700404765056502	0.591419333998538	NA	NA	p.Arg152Gln	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-0.813	-3.861	3.048	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152R	152	R	R	synonymous	wt-like	1.01248518419993	0.104531469039865	6	0.0426747935352013	0.92884412582325	1.09612624257661	0.833106264195224	1.08936034036197	1.03632540588712	1.10684591036598	NA	NA	0.945678768644409	1.06359441574486	0.70186122581703	0.650731023317272	0.692860141000584	0.728605323810971	0.759724012892223	NA	NA	0.680262640280426	0.710862310633476	NA	NA	p.Arg152=	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152S	152	R	S	missense	wt-like	0.898743482495411	0.0652538114825354	6	0.0266397569839963	0.846530518249879	0.950956446740943	0.829598625517833	0.838302253750747	0.992530798604305	0.95626661204811	NA	NA	0.871831361987786	0.903931243063684	0.670012840612634	0.649983900593892	0.638578427832849	0.715501320263684	0.709851566167581	NA	NA	0.665071853998563	0.674953827226706	NA	NA	p.Arg152Ser	1	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-0.813	-3.109	2.296	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152T	152	R	T	missense	wt-like	0.982916133926681	0.0922534286615162	6	0.0376623045404939	0.909099373452534	1.05673289440083	1.03119528269723	0.914700428596914	1.01515609219508	0.934619904531439	NA	NA	1.12651018774359	0.875314907795833	0.697802916695327	0.692923740579963	0.655096612407242	0.722271147552175	0.702682092810692	NA	NA	0.717460580803302	0.668517971149989	NA	NA	p.Arg152Thr	1	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-0.813	-3.123	2.31	0.002793766	NA	NA	NA	NA	1.44e-05	NA	NA
R152V	152	R	V	missense	wt-like	1.05088120725538	0.170745573372268	6	0.0697065884335004	0.914258804440563	1.1875036100702	0.705614886412596	1.09687468943051	1.13553510115587	1.08949760836351	NA	NA	1.12663369249335	1.15113126567645	0.724017731929261	0.623575516682467	0.69448483170976	0.758290353073397	0.753978188087309	NA	NA	0.717485986357042	0.730549477501481	NA	NA	p.Arg152Val	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-0.813	-3.953	3.14	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152W	152	R	W	missense	low	0.585860042688242	0.14209133437371	6	0.0580085443477963	0.472165384970967	0.699554700405517	0.640147431025419	0.840778505978682	0.585385638479961	0.472726140592098	NA	NA	0.511411733947036	0.464710806106257	0.592304543783565	0.609631029219468	0.63911382270892	0.593677379976331	0.549701089499856	NA	NA	0.590931707590798	0.576172502093617	NA	NA	p.Arg152Trp	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-0.813	-5.561	4.748	0.002793766	NA	NA	NA	NA	NA	NA	NA
R152X	152	R	X	nonsense	low	-0.0625790128231836	0.140511823197878	6	0.0573637116104942	-0.175009821599294	0.0498517959529271	-0.0147669892806569	0	0.130582872193395	-0.0740589285063516	NA	NA	-0.287416268316653	-0.129814763028835	0.449895218713582	0.470135063334043	0.457327614126021	0.457593568920597	0.368603757176811	NA	NA	0.426608733938111	0.442462823301142	NA	NA	p.Arg152Ter	1	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R152Y	152	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg152Tyr	0	27.4	13.7	18.4	0.989	78	1.5	-144.2	131	20	-1.2	0	0	11.4	2	1094	0	0	5	9.13879240128142	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-0.813	-4.409	3.596	0.002793766	NA	NA	NA	NA	NA	NA	NA
G153A	153	G	A	missense	possibly_low	0.712379978430937	0.234785824557268	6	0.095850911500653	0.524515644004321	0.900244312857553	0.340469564236833	0.741574082285694	0.577814001575037	0.70344504044285	NA	NA	0.961003792865794	0.949973389179417	0.621890370654514	0.54580001224076	0.617664658714405	0.591411832617494	0.626116082594622	NA	NA	0.683415075528341	0.685308773906303	NA	NA	p.Gly153Ala	1	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.217	-1.096	-0.121	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153C	153	G	C	missense	possibly_low	0.654156472030081	0.188288770733421	6	0.0768685687654614	0.503496845706636	0.804816098353526	0.761345176032591	0.897881647734383	0.355505606899452	0.619784901499739	NA	NA	0.556221620348911	0.73419987966541	0.617797664211466	0.635445999815182	0.651460194035168	0.524893825649009	0.598407520600869	NA	NA	0.60014932860775	0.6367809928539	NA	NA	p.Gly153Cys	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.217	-5.055	3.838	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153D	153	G	D	missense	wt-like	1.24502255269326	0.204147458782651	6	0.0833428510505593	1.08167356626528	1.40837153912124	1.16154808658591	0.884107561755155	1.31873017297819	1.26949999291512	NA	NA	1.46907868605145	1.36717081587373	0.783532875368747	0.720688727455387	0.648482074531573	0.813105067028989	0.813595674914139	NA	NA	0.78792865924092	0.779137091496575	NA	NA	p.Gly153Asp	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.217	-3.929	2.712	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153E	153	G	E	missense	possibly_wt-like	0.736988553564523	0.1743263287101	6	0.07116842567874	0.597501002397777	0.876476104731269	0.82444532034686	0.906604382403579	0.610327729795615	0.943048673449559	NA	NA	0.583239234448803	0.554265980942724	0.627296620929274	0.648886252931788	0.653346151933368	0.601140427902903	0.705473733716973	NA	NA	0.60570698892676	0.596313593214405	NA	NA	p.Gly153Glu	1	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.217	-3.872	2.655	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153F	153	G	F	missense	possibly_wt-like	0.826368917515622	0.39403311109135	5	0.176216964357197	0.480990013910537	1.17174782112071	0.291382341932866	NA	0.780020559303782	0.885739369014801	NA	NA	0.776753949015176	1.39794836831148	0.651915068384645	0.535344494274422	NA	0.651915068384645	0.686492670156594	NA	NA	0.645513947687578	0.786059008507574	NA	NA	p.Gly153Phe	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.217	-4.53	3.313	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153G	153	G	G	synonymous	wt-like	0.9289633210196	0.0600550131902564	6	0.0245173564687069	0.880910185344804	0.977016456694395	0.95355582265978	1.01591276729552	0.831885894881754	0.939747007073824	NA	NA	0.914220827153749	0.918457607052971	0.676683271179014	0.676386631099787	0.676979911258241	0.667433954922569	0.704380209027551	NA	NA	0.673791582085058	0.678220827947728	NA	NA	p.Gly153=	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153H	153	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly153His	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.217	-5.008	3.791	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153I	153	G	I	missense	low	0.311844862356123	0.335430531622784	6	0.136938941104386	0.0434494697104743	0.580240255001772	0.597271666770212	0.622615952150386	0.390037778524564	0.465732742060749	NA	NA	-0.025800460325441	-0.178788505043729	0.541305609153919	0.60049854417652	0.591944510894693	0.535226369483659	0.547384848824178	NA	NA	0.48042443318982	0.431448556372971	NA	NA	p.Gly153Ile	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.217	-4.132	2.915	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153K	153	G	K	missense	possibly_low	0.696565206972954	0.28432368693579	6	0.116074659129919	0.469063055560549	0.924067358385358	1.05249205309154	1.07229891477806	0.502897723301354	0.520502101938957	NA	NA	0.549791559140567	0.481408889587242	0.589377279062492	0.697459926475833	0.689171259983926	0.568995758192891	0.565524672911435	NA	NA	0.598826632388377	0.579927925736608	NA	NA	p.Gly153Lys	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.217	-3.294	2.077	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153L	153	G	L	missense	wt-like	1.06590555478102	0.192472494793091	6	0.078576566960594	0.911898313509458	1.21991279605259	0.867810860626377	0.783871931316101	1.21190204335673	1.14185171527689	NA	NA	1.14008427452096	1.24991250358907	0.736509181585887	0.658123059665418	0.626809951501712	0.781140487909249	0.771318071039494	NA	NA	0.720252839333995	0.75276552383778	NA	NA	p.Gly153Leu	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.217	-3.73	2.513	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153M	153	G	M	missense	wt-like	1.02486577702138	0.134020402987674	6	0.0547136004069961	0.917629090759156	1.13210246328361	0.863615836756513	1.08361575254923	0.95699532986043	0.962153070455546	NA	NA	1.25242780284819	1.0303868696584	0.704131229669865	0.657229524741625	0.691618093504218	0.704868574878685	0.711801183987568	NA	NA	0.743362473188907	0.703393884461046	NA	NA	p.Gly153Met	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.217	-4.999	3.782	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153N	153	G	N	missense	wt-like	1.04206787024491	0.271975121828728	6	0.111033378535279	0.824446447233962	1.25968929325586	0.547875816646799	0.930943074890438	1.13010137394452	1.18881471102031	NA	NA	1.13974432817555	1.31492791679185	0.738423705507771	0.589977288864297	0.658608463704649	0.756664500369828	0.786872397094986	NA	NA	0.720182910645715	0.767387586314505	NA	NA	p.Gly153Asn	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.217	-3.142	1.925	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153P	153	G	P	missense	low	-0.03500481055037	0.137470770067806	6	0.0561222068689327	-0.145002314746384	0.0749926936456445	0.0469481871797314	0.124066032245481	-0.0144995189958269	0.00240574969442473	NA	NA	-0.27382998511348	-0.0951193283125499	0.439834689579981	0.483280320001484	0.484152150499697	0.414182740813038	0.393929154708117	NA	NA	0.429403501335481	0.45026587782448	NA	NA	p.Gly153Pro	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.217	-4.125	2.908	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153Q	153	G	Q	missense	possibly_low	0.573377988733797	0.435726087994621	6	0.177884430534311	0.224730911476131	0.922025065991463	1.03745031520697	1.17857696056255	0.09159532182951	0.28404940738018	NA	NA	0.363544670566313	0.485051256857254	0.570630900915317	0.69425605480994	0.712149824328021	0.445927908923485	0.487210624805121	NA	NA	0.560514702314123	0.580747099516511	NA	NA	p.Gly153Gln	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.217	-4.331	3.114	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153R	153	G	R	missense	wt-like	1.00187845908832	0.0515376281504461	6	0.0210401485869819	0.960640525628466	1.04311639254818	0.965900458532073	0.991678933621776	0.925873339732804	1.0226030463125	NA	NA	1.06887145550176	1.03634352082902	0.700144976309978	0.679016023354892	0.671740271196498	0.695556408510862	0.731822450085301	NA	NA	0.705604001098148	0.704733544109093	NA	NA	p.Gly153Arg	1	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.217	-4.133	2.916	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153S	153	G	S	missense	possibly_wt-like	0.748931267246624	0.287017324970551	6	0.117174332252739	0.519273796118726	0.978588738374521	1.17073458746504	1.03989047842617	0.596436490270079	0.676789593869722	NA	NA	0.475484497314452	0.534251956134282	0.60713582804654	0.722645440841913	0.682164174611718	0.596983960627302	0.617287695465778	NA	NA	0.583541292705666	0.591812409468221	NA	NA	p.Gly153Ser	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.217	-3.412	2.195	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153T	153	G	T	missense	possibly_wt-like	0.781126744735046	0.144596934637721	6	0.0590314513721647	0.665427226090476	0.896826263379616	1.0107826230999	0.767070824155335	0.755392191227414	0.871840831427394	NA	NA	0.681752998670506	0.599920999829732	0.635258830642603	0.688575869196263	0.623177354391971	0.644545891158041	0.681889420685241	NA	NA	0.625971770127165	0.606581474408358	NA	NA	p.Gly153Thr	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.217	-3.731	2.514	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153V	153	G	V	missense	possibly_low	0.65924594138936	0.172475936434305	6	0.0704130061954588	0.521238985203065	0.797252897575655	0.931456499323345	0.805617551926445	0.506799176445217	0.530506326578002	NA	NA	0.546029505498852	0.635066588564298	0.606269264049732	0.671679502414501	0.631511610613984	0.570163131506838	0.568838110853475	NA	NA	0.598052758864044	0.614485769235421	NA	NA	p.Gly153Val	1	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.217	-3.193	1.976	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153W	153	G	W	missense	possibly_wt-like	0.785506360527811	0.281081331702204	6	0.114750973148731	0.560598585965376	1.01041413509025	1.03666529651432	1.20811245461071	0.647244442662978	0.762066145407828	NA	NA	0.493510718864681	0.565439105106339	0.628859040911486	0.694088846794093	0.718535745760906	0.612186462252385	0.645531619570588	NA	NA	0.587249377951128	0.598826445344884	NA	NA	p.Gly153Trp	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.217	-5.603	4.386	0.003863467	NA	NA	NA	NA	NA	NA	NA
G153X	153	G	X	nonsense	low	-0.130997952248222	0.18473701052659	8	0.065314396439741	-0.259011816942085	-0.00298408755435822	-0.0646897375034213	-0.306645004156642	-0.0245915009514262	-0.0387711944825986	-0.290841253786476	0.215175534530456	-0.25385771846107	-0.283762743174595	0.422337483167969	0.459501579374819	0.391027355151589	0.411163068402431	0.380291191338032	0.463461073975661	0.521354544523999	0.433511897933508	0.407839695138655	NA	NA	p.Gly153Ter	1	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G153Y	153	G	Y	missense	low	0.367724577230505	0.351490888652222	6	0.143495554405894	0.0864784586533459	0.648970695807664	0.70841331899878	0.833285012258267	0.272055938200938	0.0267159433623274	NA	NA	0.396460068765193	-0.0305828182024745	0.533604999766695	0.624171579380846	0.637493641171467	0.499924432783275	0.401980784992705	NA	NA	0.567285566750116	0.464780234288172	NA	NA	p.Gly153Tyr	0	26.3	10.6	16.7	0.821	119.6	85.8	56.6	30.3	28.8659793814433	-1	0	0	13.38	0	0	0	0	6	6.85440132052464	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.217	-4.609	3.392	0.003863467	NA	NA	NA	NA	NA	NA	NA
A154A	154	A	A	synonymous	wt-like	1.20483741807794	0.121603927054086	6	0.0496445953335231	1.10753579919716	1.30213903695871	1.27323639374328	1.08524332297595	1.40462021885321	1.22380501831728	NA	NA	1.1030864027761	1.1390331518018	0.736153396652791	0.744478199487083	0.691969993386256	0.838804657358788	0.798461322372504	NA	NA	0.712642189373418	0.7278285938185	NA	NA	p.Ala154=	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154C	154	A	C	missense	possibly_low	0.594084581922246	0.166092863338618	6	0.067807127516239	0.461185054095303	0.72698410974919	0.542004381702822	0.908455562484864	0.529729111494509	0.461666791910921	NA	NA	0.482046678456093	0.64060496548427	0.586808923554849	0.588726680443947	0.653746398854511	0.577024112090237	0.546038190389071	NA	NA	0.584891166665751	0.61573135838658	NA	NA	p.Ala154Cys	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-0.993	-4.922	3.929	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154D	154	A	D	missense	low	-0.357349464700406	0.429233632796656	6	0.175233896798828	-0.700801591296718	-0.0138973381040941	0.198275885590427	0.0668418633684832	-0.435045014938498	-0.340368039284189	NA	NA	-0.860775709438265	-0.773025773500393	0.303234752131507	0.515512933607934	0.471779611685389	0.288349219004284	0.280401148399091	NA	NA	0.308665787434032	0.297803716828981	NA	NA	p.Ala154Asp	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-0.993	-3.878	2.885	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154E	154	A	E	missense	low	-0.309976872694443	0.341754510754739	6	0.139520694773936	-0.583432409549363	-0.0365213358395219	0.0363155026170161	0.118522185961956	-0.369783169070382	-0.309856055991247	NA	NA	-0.770451677023456	-0.564608022660543	0.335961538066262	0.48101557126937	0.482953505684585	0.307876542408182	0.290506835424065	NA	NA	0.327245899243638	0.344677176888887	NA	NA	p.Ala154Glu	1	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-0.993	-3.743	2.75	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154F	154	A	F	missense	low	0.286026341850053	0.0753451817450486	6	0.0307595416421052	0.225738748050567	0.346313935649539	0.281967329498493	0.304255088161744	0.239323472173665	0.406686136109061	NA	NA	0.181083536036846	0.30284248912051	0.525469764703879	0.533339108207732	0.523111145134105	0.49013038786439	0.527828384273652	NA	NA	0.52298152105738	0.539768078475085	NA	NA	p.Ala154Phe	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-0.993	-4.47	3.477	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154G	154	A	G	missense	possibly_wt-like	0.780033641773855	0.123491383937875	6	0.0504151463796542	0.681221770594418	0.878845512953292	0.8826383063163	0.967647881254434	0.723903748203371	0.735572070034106	NA	NA	0.624322014314942	0.746117830519974	0.638109018407704	0.661281287357462	0.666544474839845	0.635124076585737	0.6367566792079	NA	NA	0.614157925216415	0.639461357607508	NA	NA	p.Ala154Gly	1	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-0.993	-2.517	1.524	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154H	154	A	H	missense	low	0.252409114300531	0.172897527782399	6	0.0705851201425926	0.114064820976617	0.390753407624446	0.0152206522480367	0.197328485759033	0.394501661741254	0.352530770480131	NA	NA	0.448766866643767	0.106106248930966	0.504942136337696	0.476522394090505	0.499992355215928	0.536562030313506	0.509891917459463	NA	NA	0.578045340500285	0.495521807417556	NA	NA	p.Ala154His	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-0.993	-4.963	3.97	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154I	154	A	I	missense	low	-0.130379409440948	0.234466866232976	6	0.0957206973100317	-0.317988528743671	0.0572297098617738	-0.0801875089358802	0.256326977474652	-0.128398472534475	-0.114273391669527	NA	NA	-0.260292865027752	-0.455451195952709	0.406145310362091	0.456200573124213	0.512748523510939	0.380102465094062	0.355284571245742	NA	NA	0.432188155630119	0.36922670847311	NA	NA	p.Ala154Ile	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-0.993	-4.066	3.073	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154K	154	A	K	missense	low	0.224764958704212	0.278122610829956	6	0.113543080410676	0.00222461040555186	0.447305307002872	0.598619700191903	0.557882869384404	0.0286377174560448	-0.0263170782693703	NA	NA	0.0751420223629802	0.11462452109931	0.49931319675772	0.600785673637064	0.577948456520999	0.427090049145205	0.384416042856702	NA	NA	0.501188814103161	0.49743757941228	NA	NA	p.Ala154Lys	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-0.993	-3.742	2.749	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154L	154	A	L	missense	possibly_low	0.69463186712796	0.150401110777961	6	0.0614009963589688	0.574288125649506	0.814975608606414	0.418019126444084	0.682821582201915	0.798757644521044	0.851938859657951	NA	NA	0.692371438650231	0.723882551292534	0.631308323787211	0.562317973593691	0.604961676705411	0.657521485393187	0.675297810564362	NA	NA	0.628156037113395	0.634460610461028	NA	NA	p.Ala154Leu	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-0.993	-3.634	2.641	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154M	154	A	M	missense	possibly_low	0.671681734277387	0.150456119913828	6	0.0614234537446462	0.551293977131819	0.792069491422955	0.48430277223203	0.725953595468339	0.821959245006114	0.830732370862982	NA	NA	0.660126896422441	0.507015525672416	0.617905248386573	0.576436308608021	0.614287325618288	0.664463752350754	0.668274139352857	NA	NA	0.621523171154859	0.585686896020906	NA	NA	p.Ala154Met	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-0.993	-4.888	3.895	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154N	154	A	N	missense	low	0.12008502496071	0.224965733546546	6	0.0918418761333262	-0.0599217445331977	0.300091794454618	-0.165840684625179	0.264493046883888	0.160535762289536	-0.0107331838929859	NA	NA	0.00711092898361005	0.464944280125393	0.476875197997941	0.437956552068227	0.514514123828233	0.46655592301905	0.389577489023147	NA	NA	0.487194472976832	0.576225010745433	NA	NA	p.Ala154Asn	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-0.993	-3.946	2.953	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154P	154	A	P	missense	low	0.250959881748584	0.152661727453332	6	0.0623238892520831	0.128807303438038	0.37311246005913	0.388428903372227	0.261015123925395	0.367596628602001	0.298814450453762	NA	NA	-0.0334187067909093	0.223322890929027	0.517823079659165	0.556015292479653	0.513762155950995	0.528511640743396	0.492100864249057	NA	NA	0.478857321233708	0.521884003367335	NA	NA	p.Ala154Pro	1	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-0.993	-4.057	3.064	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154Q	154	A	Q	missense	low	0.275004420540913	0.289272653374376	6	0.118095066218035	0.043542344001692	0.506466497080134	0.607269112255625	0.451267346749915	0.130418599891057	0.458234365731494	NA	NA	-0.189301356852025	0.192138455469412	0.529885967654963	0.602627987766605	0.554896925709982	0.457544416183168	0.544901357546296	NA	NA	0.44679146910244	0.514870577763629	NA	NA	p.Ala154Gln	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-0.993	-4.195	3.202	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154R	154	A	R	missense	low	0.273944352209001	0.113482481050337	6	0.046329028886398	0.183141124152945	0.364747580265057	0.327342568023472	0.452907783614943	0.128034301340518	0.187453454097685	NA	NA	0.293221068299718	0.25470693787767	0.535973150042617	0.543003978195425	0.555251607467416	0.456830998285337	0.455217671007928	NA	NA	0.546048780476544	0.52894232188981	NA	NA	p.Ala154Arg	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-0.993	-3.428	2.435	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154S	154	A	S	missense	wt-like	1.00954648076467	0.129366286494082	6	0.0528135653048671	0.90603379487198	1.11305916665737	0.835230772273142	0.895413723383492	1.01139848914604	1.04074358481572	NA	NA	1.19501649488617	1.07947582008348	0.71779043913782	0.651183540924415	0.650926599744129	0.721146816344774	0.737830666687215	NA	NA	0.731552675812156	0.714434061930867	NA	NA	p.Ala154Ser	1	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-0.993	-1.42	0.427	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154T	154	A	T	missense	low	0.286188995716656	0.170427884932377	6	0.0695768926710147	0.149820791925258	0.422557199508054	0.520212898309987	0.480356630879781	0.111212352972249	0.222166658196636	NA	NA	0.200179484987316	0.183005948953966	0.519863159107074	0.58408512128796	0.561186371306839	0.451797618954714	0.466714818633175	NA	NA	0.526909654657315	0.512816663556833	rs1800460	*3B	p.Ala154Thr	1	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-0.993	-3.521	2.528	0.004338314	0.361022364	0.107289846341653	0.8	NA	0.0277	NA	NA
A154V	154	A	V	missense	low	0.220376630232342	0.164827487708077	6	0.0672905400782757	0.0884895951786724	0.352263665286011	0.440992705712351	0.41764013598838	0.108355231102061	0.147825210013187	NA	NA	0.143895597038997	0.0635509015390754	0.500641410110195	0.567211317716995	0.547626326965974	0.4509427252259	0.442092643105864	NA	NA	0.515331773298382	0.485951046922007	NA	NA	p.Ala154Val	1	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-0.993	-3.656	2.663	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154W	154	A	W	missense	low	0.0381145407737089	0.278239230552962	6	0.113590690213227	-0.184519121023263	0.260748202570681	0.324506934186787	0.36678607108987	-0.147641179350384	-0.218670452533621	NA	NA	-0.250278110797917	0.153983982047519	0.470268910859799	0.542399991676452	0.536631079605116	0.37434475851739	0.320707860407557	NA	NA	0.434248241394243	0.506289580325354	NA	NA	p.Ala154Trp	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-0.993	-5.689	4.696	0.004338314	NA	NA	NA	NA	NA	NA	NA
A154X	154	A	X	nonsense	possibly_low	0.694793370789221	0.541682699920495	6	0.221141036216392	0.261364904301226	1.12822183727722	-0.0578483215778898	0.117718512571656	1.30854271958348	0.820574270637599	NA	NA	0.968128827975333	1.01164421554515	0.674895234313257	0.460958792551023	0.482779742038723	0.810056828131446	0.664909737220736	NA	NA	0.684880731405778	0.699178633862411	NA	NA	p.Ala154Ter	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A154Y	154	A	Y	missense	low	0.430775957438186	0.355343724607318	6	0.145068468097999	0.14644698467371	0.715104930202663	0.709313431599668	1.01375933905995	0.179782424759606	0.121739494311565	NA	NA	0.209520219634755	0.350540835263573	0.53966329908031	0.624363302257566	0.676514314728815	0.472314813186794	0.433452953047959	NA	NA	0.528831091173084	0.550495506987537	NA	NA	p.Ala154Tyr	0	25.3	12.9	13.8	0.627	87.1	33.5	-121.9	-73.7	0	-3.6	0	0	12.55	0	0	0	0	9	5.75124011995286	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-0.993	-4.56	3.567	0.004338314	NA	NA	NA	NA	NA	NA	NA
L155A	155	L	A	missense	low	0.180615900345008	0.418946192514916	6	0.171034066890559	-0.154604710889902	0.515836511579918	0.701442003241554	0.536792330863992	-0.0918326469898943	0.264140643909904	NA	NA	0.120766013837593	-0.4476129427931	0.495595332955654	0.622686697700287	0.573388433866597	0.391043508692224	0.480616765246625	NA	NA	0.510573900664684	0.370989543188176	NA	NA	p.Leu155Ala	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.126	-3.129	2.003	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155C	155	L	C	missense	wt-like	1.12800147815403	0.227071057442028	4	0.113535528721014	0.905475930895129	1.35052702541293	NA	NA	0.830265510912045	1.07162972121609	NA	NA	1.29602278656886	1.31408789391912	0.750195228614848	NA	NA	0.666949111728294	0.748060274670284	NA	NA	0.752330182559412	0.76719866392946	NA	NA	p.Leu155Cys	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.126	-5.103	3.977	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155D	155	L	D	missense	low	0.272871325331685	0.332444986716882	6	0.135720097500449	0.00686482225254142	0.53887782841083	-0.0495068905909485	-0.0991571495753082	0.146381149884685	0.755518570209749	NA	NA	0.396658982052577	0.487333290009359	0.515030995656385	0.462735507090071	0.435888671352144	0.462320650626588	0.64336303730935	NA	NA	0.567326484222699	0.581260332143673	NA	NA	p.Leu155Asp	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.126	-4.429	3.303	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155E	155	L	E	missense	possibly_wt-like	0.895007633721115	0.563994813799927	6	0.230249918564305	0.443726085891797	1.34628918155043	0.319086822559243	0.11840162817516	1.03013413164476	1.36549694814392	NA	NA	1.00665051995151	1.53027575185209	0.709778820295361	0.541245514567309	0.482927439672168	0.726752801670284	0.845390238236315	NA	NA	0.692804838920437	0.815819632553406	NA	NA	p.Leu155Glu	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.126	-4.237	3.111	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155F	155	L	F	missense	possibly_wt-like	0.815032391112578	0.474561086758433	6	0.193738752389803	0.435311414018841	1.19475336820632	1.321937616322	1.38835599020582	0.822425352602454	0.412137728563094	NA	NA	0.740609015971246	0.20472864301086	0.651340985141258	0.754851499986778	0.757506519543082	0.664603218736567	0.529633972805844	NA	NA	0.63807875154595	0.517702129541214	NA	NA	p.Leu155Phe	1	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.126	-2.23	1.104	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155G	155	L	G	missense	low	-0.0157684762078083	0.0321826334960084	6	0.0131385051073705	-0.0415194730289499	0.00998252061333341	-0.0328907272105374	0.0438867388144679	-0.0500914652004586	-0.011473795889587	NA	NA	-0.0271197390565645	-0.0169218687041699	0.466545586517488	0.466274729449806	0.466816443585171	0.403533096524452	0.389332195461835	NA	NA	0.480153050860257	0.467852602011692	NA	NA	p.Leu155Gly	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.126	-4.104	2.978	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155H	155	L	H	missense	low	-0.249530116402954	0.129616986607038	6	0.0529159131974008	-0.353243400478908	-0.145816832327001	-0.386415468417336	-0.0102718563261504	-0.217427674497478	-0.287477697392416	NA	NA	-0.318904551609072	-0.276683450175275	0.400203116525974	0.390974394459489	0.455106717893112	0.353463592166139	0.297918634452701	NA	NA	0.420131434280154	0.409431838592458	NA	NA	p.Leu155His	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.126	-5.136	4.01	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155I	155	L	I	missense	wt-like	0.868085367445244	0.149285241929561	6	0.0609454448092276	0.748634490597384	0.987536244293104	0.787266276886576	0.854952529667475	0.968538539402988	1.06584892201916	NA	NA	0.634303997029847	0.897601939665422	0.657854385497278	0.640967162410366	0.642178413452413	0.708322476356004	0.746145651589984	NA	NA	0.616211269713622	0.673530357542143	NA	NA	p.Leu155Ile	1	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.126	-2.425	1.299	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155K	155	L	K	missense	low	-0.147364944112418	0.251931417312178	6	0.102850570431835	-0.348948357948214	0.0542184697233786	0.0730270935338805	0.141956912508384	-0.122331050762909	-0.0995470715011572	NA	NA	-0.517586957058933	-0.359708591393773	0.38633864519826	0.488835094974078	0.488020369380266	0.381917928717335	0.360161985513517	NA	NA	0.37926145528158	0.390759361679185	NA	NA	p.Leu155Lys	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.126	-4.118	2.992	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155L	155	L	L	synonymous	possibly_low	0.710868182932544	0.19041825394639	6	0.0777379266467273	0.558504646472141	0.863231719392946	0.610691844881134	0.757721396926341	0.674004015474403	1.05976244076562	NA	NA	0.502412811012647	0.660616588535118	0.620212664942003	0.60335702560538	0.621155898186448	0.620193327910075	0.744129785428775	NA	NA	0.5890805834789	0.620232001973932	NA	NA	p.Leu155=	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155M	155	L	M	missense	wt-like	1.03610564705335	0.119661046950822	6	0.0488514178527893	0.940358627468165	1.13185266663853	0.951961224282419	0.89052565937832	1.20131003584742	1.14487039811766	NA	NA	0.973864989134266	1.05410157556001	0.697394022857979	0.676046983606997	0.649869742775865	0.777971200351111	0.772317870486275	NA	NA	0.686060688863849	0.708727356852109	NA	NA	p.Leu155Met	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.126	-2.417	1.291	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155N	155	L	N	missense	low	0.0403909571969584	0.177303233511636	6	0.0723837419748406	-0.101478570139969	0.182260484533886	0.0948386688404237	0.290001944918499	0.0715605272275902	0.112276641483801	NA	NA	-0.125073991402777	-0.201258047885786	0.449968280944711	0.493480933682969	0.520029447811738	0.439933197797585	0.43031881954629	NA	NA	0.460003364091837	0.426395122993485	NA	NA	p.Leu155Asn	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.126	-4.485	3.359	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155P	155	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu155Pro	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.126	-4.49	3.364	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155Q	155	L	Q	missense	low	-0.392497971614317	0.0524569533187986	2	0.0370926674121087	-0.465198263832572	-0.319797679396061	-0.429590639026425	-0.355405304202208	NA	NA	NA	NA	NA	NA	0.381131470313049	0.381778136231478	0.380484804394621	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu155Gln	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.126	-4.508	3.382	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155R	155	L	R	missense	low	0.126608125666522	0.165670796046202	6	0.0676348192656491	-0.00595368419502593	0.25916993552807	-0.03403726124065	-0.0138654058486032	0.125490325398378	0.0349543112206548	NA	NA	0.377021900231932	0.270084884237421	0.461050160814051	0.466030519111796	0.454329750191873	0.456069802516307	0.40470936433065	NA	NA	0.563287036845435	0.532400844743994	NA	NA	p.Leu155Arg	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.126	-4.384	3.258	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155S	155	L	S	missense	low	-0.0135987684431971	0.12859539121973	6	0.0524988486269864	-0.11649462098191	0.0892970840955162	-0.0175068791577451	0.241320858594545	-0.0478537459700198	-0.072328594698515	NA	NA	-0.0756449988411939	-0.109579250586254	0.458282645052067	0.469551470160686	0.509504023993693	0.404202655690587	0.369176850434723	NA	NA	0.470171158685116	0.447013819943448	NA	NA	p.Leu155Ser	1	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.126	-3.968	2.842	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155T	155	L	T	missense	wt-like	1.04763989784245	0.148066026470783	6	0.0604477021824742	0.929164578616599	1.1661152170683	1.14873197247023	0.985776544039366	1.1969261349005	1.18581359707454	NA	NA	0.904666722906525	0.863924415663547	0.694892582637157	0.717958910914427	0.670464105100272	0.776659471416352	0.785878416534265	NA	NA	0.671826254359888	0.665956232642237	NA	NA	p.Leu155Thr	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.126	-3.348	2.222	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155V	155	L	V	missense	possibly_low	0.683046808974383	0.118242292532822	6	0.0482722137870524	0.588435008497742	0.777658609451023	0.713624168139931	0.898906965273462	0.550264977722159	0.65217575650688	NA	NA	0.628146485692063	0.655162500511803	0.616975003952903	0.62528148383781	0.65168187975465	0.583168751364107	0.609135497213559	NA	NA	0.614944638385654	0.619005369520152	NA	NA	p.Leu155Val	1	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.126	-2.538	1.412	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155W	155	L	W	missense	low	0.579898208644403	0.159437354297375	6	0.0650900273279845	0.452324099328826	0.707472317959981	0.794329471052641	0.618922282433785	0.65029681726296	0.417322175021912	NA	NA	0.366583912516107	0.631934593579013	0.602122837278215	0.642471614078984	0.591145896029108	0.613099778527321	0.531351081549892	NA	NA	0.561139889805579	0.613781378936327	NA	NA	p.Leu155Trp	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.126	-5.345	4.219	0.00492843	NA	NA	NA	NA	NA	NA	NA
L155X	155	L	X	nonsense	possibly_low	0.528799654033372	0.650433805718931	6	0.265538489244658	0.00835377860466602	1.04924552946208	-0.404629736770123	-0.182747136772603	0.809085736632788	0.938945424071238	NA	NA	0.873079081457191	1.13906455558174	0.662970160864866	0.387094777706538	0.417815532302994	0.660611805504863	0.704114721632946	NA	NA	0.665328516224869	0.727835656575002	NA	NA	p.Leu155Ter	1	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L155Y	155	L	Y	missense	low	0.451646764437432	0.209242043860655	6	0.0854227066992772	0.28422133584492	0.619072193029944	0.56610558753579	0.76628019241465	0.353790908590489	0.538238849016753	NA	NA	0.27774588987101	0.207719159195899	0.557132304987898	0.593860207638388	0.62300641050425	0.524380762189436	0.571399152229558	NA	NA	0.542865457746238	0.518374701049126	NA	NA	p.Leu155Tyr	0	28.2	13.7	11.5	0.91	125.6	49.8	-49.6	-40.8	0	-0.9	0	0	11.7	0	0	0	0	5	9.08231744600918	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.126	-3.124	1.998	0.00492843	NA	NA	NA	NA	NA	NA	NA
V156A	156	V	A	missense	possibly_wt-like	0.797237010207943	0.106976056938385	6	0.0436727923656607	0.711639910066952	0.882834110348934	0.8522260115592	0.96755096397953	0.698568844337644	0.753773543493619	NA	NA	0.826734175029563	0.684568522848101	0.648794291844524	0.654803505985735	0.666523520184337	0.627543493250836	0.642785077703312	NA	NA	0.655795133799287	0.62561882738517	NA	NA	p.Val156Ala	1	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.296	-2.786	1.49	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156C	156	V	C	missense	wt-like	0.928600224191908	0.181541379190739	6	0.074113957703071	0.783339536342164	1.07386091204165	0.894802081926803	1.18221734276867	1.09461064175027	0.902880775257927	NA	NA	0.692590495338314	0.804500008109464	0.678021063442046	0.66387215659929	0.712936917806669	0.746045140831656	0.692169970284803	NA	NA	0.628201098185719	0.65259159559551	NA	NA	p.Val156Cys	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.296	-3.925	2.629	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156D	156	V	D	missense	wt-like	1.11299237174059	0.135382932351191	5	0.0605450879461039	0.994326179925414	1.23165856355576	1.15893891065503	1.33086699017654	1.02230894245043	NA	NA	NA	1.04257743764167	1.01026957777927	0.720132976191775	0.720132976191775	0.745076721116706	0.724411387662424	NA	NA	NA	0.700195188197494	0.698869475798108	NA	NA	p.Val156Asp	1	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.296	-3.529	2.233	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156E	156	V	E	missense	possibly_low	0.706503578466154	0.199934082972388	6	0.0816227475789377	0.546525932892232	0.866481224040075	1.03820386249799	0.773113683677345	0.447817789523106	0.583664113950214	NA	NA	0.657753475393508	0.738468545754761	0.622759419073943	0.694416559455953	0.624483891742407	0.552515015644992	0.586444175885894	NA	NA	0.621034946405478	0.637741022163506	NA	NA	p.Val156Glu	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.296	-4.044	2.748	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156F	156	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val156Phe	1	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.296	-4.275	2.979	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156G	156	V	G	missense	possibly_wt-like	0.771781265534525	0.0739663908678923	6	0.0301966526235989	0.712596913938604	0.830965617130446	0.695691139453782	0.886666216835362	0.807472319610562	0.803105097435821	NA	NA	0.734907540430098	0.702845279441527	0.642970607484808	0.621461770787888	0.649035285874149	0.660129046925799	0.659123879406536	NA	NA	0.636905929095467	0.629729296943326	NA	NA	p.Val156Gly	1	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.296	-3.007	1.711	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156H	156	V	H	missense	possibly_low	0.648064445106832	0.156884989387674	6	0.0640480287169593	0.522532615540805	0.773596274672859	0.640418985944849	0.952755310980757	0.57195695962532	0.527592675963972	NA	NA	0.548754886310699	0.646907851815396	0.604151126805008	0.609688870083255	0.663324525867725	0.589659317793235	0.567873098486929	NA	NA	0.598613383526762	0.617148886833718	NA	NA	p.Val156His	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.296	-5.221	3.925	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156I	156	V	I	missense	low	0.232582279187902	0.555218173214817	6	0.226666870049418	-0.211676622597377	0.676841180973182	0.921642477722992	0.725691704453222	-0.460241053971764	-0.322227401141857	NA	NA	0.136057336298767	0.394570611766052	0.537058636028871	0.669589127886297	0.614230701698478	0.280810186110638	0.286409398001866	NA	NA	0.513719403289507	0.560397868768235	NA	NA	p.Val156Ile	1	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.296	-1.464	0.168	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156K	156	V	K	missense	low	0.31140421868232	0.137054798377062	6	0.055952387137305	0.20173955504416	0.42106888232048	0.316393541784307	0.537286094390325	0.193686636980505	0.191557197478299	NA	NA	0.229224798083104	0.400277043377382	0.536778136012273	0.540671849075374	0.573495191352368	0.476475162087477	0.456576846707427	NA	NA	0.532884422949173	0.561681253667747	NA	NA	p.Val156Lys	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.296	-4.099	2.803	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156L	156	V	L	missense	possibly_low	0.684928834220916	0.223694665398844	6	0.091322964734964	0.505939112378965	0.863918556062866	0.864402423707666	0.995001861492494	0.583917956104164	0.626609962175702	NA	NA	0.683702351191793	0.355938450653675	0.613520384479787	0.657397066794605	0.672458727311535	0.593238227389928	0.600668007126951	NA	NA	0.626372761832623	0.551709438662681	NA	NA	p.Val156Leu	1	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.296	-3.178	1.882	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156M	156	V	M	missense	possibly_low	0.68665915256809	0.164233768837534	6	0.0670481553643607	0.555247182824097	0.818071122312083	0.812355216716914	0.916817809593328	0.511754359499334	0.644723182764138	NA	NA	0.507428899487927	0.726875447346897	0.620900446567384	0.646311075731191	0.655554415099302	0.57164579661899	0.606667175929701	NA	NA	0.590112418331994	0.635133717205066	NA	NA	p.Val156Met	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.296	-4.592	3.296	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156N	156	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val156Asn	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.296	-3.618	2.322	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156P	156	V	P	missense	possibly_low	0.716480984135179	0.242850637747922	6	0.099143357698648	0.522163573739458	0.910798394530901	0.398576269766073	0.748105264106248	0.996960318846171	0.79970422908093	NA	NA	0.449486317281867	0.906053505729787	0.63853713786529	0.558176669038809	0.619076777093124	0.716826699175918	0.657997498637456	NA	NA	0.578193335147336	0.675431127235536	NA	NA	p.Val156Pro	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.296	-4.347	3.051	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156Q	156	V	Q	missense	possibly_wt-like	0.783984376500023	0.145407437777923	6	0.0593623378935674	0.667636332190534	0.900332420809513	0.839180982554392	0.90172954526612	0.645936437066464	0.946302274194127	NA	NA	0.794821320120651	0.575935699798386	0.650627714230177	0.65202493085499	0.652292154769578	0.611795087353967	0.706551338883217	NA	NA	0.649230497605364	0.601187144997769	NA	NA	p.Val156Gln	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.296	-3.488	2.192	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156R	156	V	R	missense	low	0.561231446915863	0.0697978419942236	6	0.0284948496722086	0.505382567813451	0.617080326018275	0.564438606878098	0.491714381588434	0.495500653556833	0.544508725380115	NA	NA	0.67948980957085	0.591736504520849	0.583490451185135	0.593505142808928	0.56364205068574	0.566782443947469	0.573475759561343	NA	NA	0.625506220644998	0.604740769322416	NA	NA	p.Val156Arg	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.296	-4.45	3.154	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156S	156	V	S	missense	possibly_wt-like	0.7935523046115	0.171156845948023	6	0.069874489759467	0.656600821244832	0.930503787978168	0.975081707464106	0.980302267550737	0.723125503497478	0.851713180239218	NA	NA	0.556683668891381	0.67440750002608	0.652085858093695	0.680971618083147	0.669280502093623	0.634891214093768	0.675223064666929	NA	NA	0.600244374337563	0.623333598341595	NA	NA	p.Val156Ser	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.296	-3.044	1.748	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156T	156	V	T	missense	wt-like	1.35128504123645	0.366259534743036	5	0.163796243418575	1.03025030333309	1.67231977913982	0.87674268972835	1.1041673598658	1.37842491062596	NA	NA	NA	1.76339454118528	1.63369570477687	0.830966628130319	0.660025528276692	0.696061592889367	0.830966628130319	NA	NA	NA	0.848470924123569	0.839078932748722	NA	NA	p.Val156Thr	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.296	-2.966	1.67	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156V	156	V	V	synonymous	possibly_wt-like	0.809397690950509	0.15123998175136	8	0.053471408341458	0.704595656398617	0.914199725502402	0.774115793282799	0.905133157234737	0.760164639836709	0.804017907683214	1.02713035420955	0.526880287113609	0.743237577913506	0.934501810329953	0.649500967559471	0.638166125579765	0.653028055736197	0.645973879382746	0.659426205695351	0.656167936127338	0.581242915615396	0.638619460075894	0.68182919296686	NA	NA	p.Val156=	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156W	156	V	W	missense	wt-like	0.86594448780413	0.143816503773011	6	0.0587128418058216	0.750869432434722	0.981019543173538	0.93007604936406	1.05788490618663	0.724057297705987	0.765085634953993	NA	NA	0.732654746506198	0.985908292107909	0.658958577236324	0.671385468271327	0.686054781679969	0.635170020900615	0.64653168620132	NA	NA	0.636442517953703	0.693390586661636	NA	NA	p.Val156Trp	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.296	-5.738	4.442	0.006283829	NA	NA	NA	NA	NA	NA	NA
V156X	156	V	X	nonsense	low	-0.0680286364810655	0.233500151231146	6	0.0953260375631687	-0.254864236893788	0.118806963931657	0.160067782905274	0.259567161035335	-0.227580394003975	-0.0468275968961576	NA	NA	-0.288348618778667	-0.265050153148203	0.419232564498341	0.507374654737507	0.513449089332283	0.35042574616906	0.377622879660059	NA	NA	0.426416944716939	0.412048184279743	NA	NA	p.Val156Ter	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V156Y	156	V	Y	missense	possibly_low	0.697944354784945	0.335138721195948	6	0.136819809996491	0.42978245482021	0.966106254749681	0.172838807564045	0.518653097382027	1.13568969457145	0.935401943448786	NA	NA	0.661182791145435	0.763899794597929	0.632600460827703	0.510094867279612	0.569466518097059	0.758336609742696	0.70294110712858	NA	NA	0.62174037405743	0.643460547597977	NA	NA	p.Val156Tyr	0	29.3	10.1	12.3	0.614	108.8	51.8	-75.2	-12.8	2.42424242424242	-4.5	0	0	11.4	0	0	0	0	8	9.45331395519779	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.296	-4.442	3.146	0.006283829	NA	NA	NA	NA	NA	NA	NA
A157A	157	A	A	synonymous	wt-like	1.10286368386189	0.293187384653909	6	0.11969324857053	0.868269227471053	1.33745814025273	0.629976222618731	0.839044488689587	1.2824671990735	1.30912935758911	NA	NA	1.26768339096061	1.28888144423981	0.754015160617949	0.607464574340906	0.638738907762403	0.80225464118515	0.826721073959782	NA	NA	0.746500625076861	0.761529696159037	NA	NA	p.Ala157=	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157C	157	A	C	missense	wt-like	0.823483698679664	0.126399903947315	6	0.051602544701288	0.722344569554521	0.924622827804806	0.853754278122056	1.01073600317799	0.807764002498146	0.893223286418918	NA	NA	0.718748472588726	0.656676149272146	0.657672673852751	0.655129024883634	0.675860633927812	0.660216322821868	0.688971372582478	NA	NA	0.633581926842635	0.61934579136247	NA	NA	p.Ala157Cys	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-0.717	-4.774	4.057	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157D	157	A	D	missense	wt-like	1.27625879951908	0.0973796434884253	3	0.0562221633816321	1.16606538415815	1.38645221488001	1.36132224409289	1.2974134396959	NA	NA	NA	NA	1.17004071476845	NA	0.737843669769332	0.763240377253172	0.737843669769332	NA	NA	NA	NA	0.726415031104397	NA	NA	NA	p.Ala157Asp	1	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-0.717	-3.205	2.488	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157E	157	A	E	missense	possibly_wt-like	0.85350717688909	0.327439226483368	6	0.133676504442645	0.591506042602298	1.11550831117588	0.901029443472539	1.15448184119161	0.594645664059613	0.326693595633724	NA	NA	1.11168107513863	1.03251144183842	0.684535140415471	0.665198576947973	0.70694017593115	0.596448118557456	0.501334545095285	NA	NA	0.71441015709135	0.703871703882968	NA	NA	p.Ala157Glu	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-0.717	-3.701	2.984	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157F	157	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala157Phe	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-0.717	-4.367	3.65	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157G	157	A	G	missense	wt-like	0.839933339850401	0.112329165551177	6	0.0458581898055001	0.750052939435419	0.929813740265383	0.825130575530693	1.05908893812334	0.74830352583816	0.839707876761157	NA	NA	0.791332609636833	0.776036513212224	0.648772531799325	0.649032211442981	0.686315107555607	0.64242485612269	0.671246861664184	NA	NA	0.648512852155668	0.646190113543934	NA	NA	p.Ala157Gly	1	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-0.717	-3.262	2.545	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157H	157	A	H	missense	wt-like	1.15389474458558	0.190825486829928	6	0.0779041787752526	1.00120535994092	1.30658412923025	1.3862238611409	1.05019957502582	1.04067435903121	0.995022153886713	NA	NA	1.41135622093852	1.03989229749032	0.726297073772525	0.768544391051795	0.68439312263006	0.729906595838805	0.722687551706245	NA	NA	0.776054855259286	0.705531669222836	NA	NA	p.Ala157His	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-0.717	-4.966	4.249	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157I	157	A	I	missense	possibly_low	0.540765456847495	0.312496998403068	6	0.127576365373141	0.290720375437616	0.790810538257374	0.74849552371942	0.981128286491072	0.391549945464778	0.674884583730772	NA	NA	0.297086039387371	0.151448362291556	0.581750286686158	0.632709039679414	0.6694590971104	0.535678832519135	0.616656748730563	NA	NA	0.546843824641753	0.505719315696361	NA	NA	p.Ala157Ile	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-0.717	-3.821	3.104	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157K	157	A	K	missense	possibly_low	0.612948530044367	0.171059642155498	6	0.0698348064773421	0.476074824481452	0.749822235607282	0.669263790429222	0.925125158657203	0.55295242800927	0.572466177391906	NA	NA	0.526520149590499	0.431363476188104	0.589006231082382	0.615832777955131	0.657350561740728	0.583972876809691	0.582735375933518	NA	NA	0.594039585355072	0.568672638330938	NA	NA	p.Ala157Lys	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-0.717	-3.752	3.035	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157L	157	A	L	missense	low	0.636532103855803	0.0956125893958983	6	0.0390336761676988	0.560027504382914	0.713036703328692	0.723000900119439	0.763992319367022	0.578537807600289	0.535150806230889	NA	NA	0.550704846741946	0.667805943075232	0.610431699356618	0.627278716214705	0.622511745424101	0.591628406239474	0.570376380500364	NA	NA	0.599014500282383	0.621848898430854	NA	NA	p.Ala157Leu	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-0.717	-3.445	2.728	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157M	157	A	M	missense	wt-like	0.903624970470953	0.162712480998247	6	0.0664270922046681	0.773430262152082	1.03381967878982	0.984697440576647	1.13040641788648	0.946197443185032	0.931247586987527	NA	NA	0.701595911492246	0.727605022697785	0.692292462794071	0.683019757407371	0.701734786055521	0.70163768518526	0.701565168180772	NA	NA	0.630053557985827	0.635297799779284	NA	NA	p.Ala157Met	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-0.717	-4.769	4.052	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157N	157	A	N	missense	possibly_wt-like	0.888225422370812	0.36447313741584	6	0.148795535270017	0.596591532181219	1.17985931256041	1.24523052028269	1.20711491730994	1.03776956464986	0.945643094511211	NA	NA	0.347594819374781	0.545999618096391	0.712326541237727	0.738512982891265	0.718320066455907	0.729037437779423	0.706333016019546	NA	NA	0.557233736987816	0.594454475998348	NA	NA	p.Ala157Asn	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-0.717	-4.082	3.365	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157P	157	A	P	missense	low	-0.0683571971311662	0.080071042114405	6	0.0326888660588658	-0.132426197301997	-0.00428819696033546	-0.128921096165666	0.0175014038796695	-0.0425247916630651	0.0114742211585462	NA	NA	-0.185806342829496	-0.0818665771669859	0.446665395107844	0.445820378993652	0.461111623628571	0.405797158769259	0.396932667574896	NA	NA	0.447510411222035	0.453246441135438	NA	NA	p.Ala157Pro	1	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-0.717	-3.972	3.255	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157Q	157	A	Q	missense	wt-like	0.880199068677206	0.130655539892172	6	0.0533399008006123	0.775654784169067	0.984743353185345	0.833014226518732	1.11403302421619	0.810231430456771	0.77858888765262	NA	NA	0.791682092926263	0.953644750292658	0.655979315036272	0.650711419405399	0.698194665636419	0.660954614285785	0.651004015786759	NA	NA	0.648584742641728	0.686134468444381	NA	NA	p.Ala157Gln	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-0.717	-4.185	3.468	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157R	157	A	R	missense	wt-like	0.822984041389206	0.0717628113493911	6	0.0292970450522696	0.76556288823331	0.880405194545102	0.790920423818087	0.844509806433316	0.806435834279387	0.761955426994004	NA	NA	0.957533473385741	0.776549283424699	0.645900192762703	0.641745491211647	0.639920573782964	0.659818914964375	0.64549494920317	NA	NA	0.682701213201443	0.646305436322236	NA	NA	p.Ala157Arg	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-0.717	-4.041	3.324	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157S	157	A	S	missense	wt-like	1.65454722269799	0.1227120787419	2	0.0867705430118952	1.48448008347569	1.82461436192029	NA	NA	NA	NA	NA	NA	1.74131776570988	1.56777667968609	0.834091633002488	NA	NA	NA	NA	NA	NA	0.843929619381496	0.824253646623479	NA	NA	p.Ala157Ser	1	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-0.717	-2.451	1.734	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157T	157	A	T	missense	possibly_low	0.548641084894678	0.367609747869483	8	0.129969672774394	0.29390520717441	0.803376962614947	0.986953501630779	0.997330391227291	0.52833472714099	0.529674603711475	-0.0352996809034871	0.107741936811524	0.61871000903704	0.655683190501813	0.594805199312439	0.683500295636619	0.672962182845961	0.576606891371787	0.568562641019215	0.500825015930724	0.500713142317085	0.613003507253091	0.619122473468122	NA	NA	p.Ala157Thr	1	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-0.717	-2.979	2.262	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157V	157	A	V	missense	possibly_wt-like	0.730892373552858	0.147459049313891	6	0.0601999047958223	0.612902728280306	0.84888201882541	0.924702027739858	0.851935693329473	0.546440864807259	0.584308759812197	NA	NA	0.759805826916368	0.718161068711991	0.637349989252807	0.670240808276199	0.64152613792931	0.582024519406998	0.586657685091789	NA	NA	0.642027632970001	0.633173840576304	NA	NA	p.Ala157Val	1	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-0.717	-2.782	2.065	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157W	157	A	W	missense	possibly_wt-like	0.739562249321082	0.0716761815616352	6	0.029261678589515	0.682210413158446	0.796914085483718	0.679626893048078	0.848161982719446	0.693137643990007	0.670312939915672	NA	NA	0.796576336404873	0.749557699848415	0.633076692962001	0.618040106064827	0.640710217280521	0.6259183966228	0.615142602595207	NA	NA	0.649591513360715	0.640234989301201	NA	NA	p.Ala157Trp	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-0.717	-5.627	4.91	0.001396552	NA	NA	NA	NA	NA	NA	NA
A157X	157	A	X	nonsense	low	-0.367297917703942	0.308664603378903	6	0.126011796656143	-0.614276500777168	-0.120319334630716	-0.26366479154535	-0.124876388681513	-0.277937381858733	-0.133137783486213	NA	NA	-0.94691136778827	-0.457259792863571	0.358928281989641	0.417120137632077	0.43032786915334	0.335358179899586	0.349036611623269	NA	NA	0.290947245423117	0.368819952356013	NA	NA	p.Ala157Ter	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A157Y	157	A	Y	missense	possibly_low	0.696824858515276	0.243965868576464	6	0.0995986487778731	0.50161509400179	0.892034623028761	0.834777034280152	0.850576756906091	0.447400028407531	0.382408501177363	NA	NA	0.664330993126932	1.00145583719359	0.631810147530406	0.651086895290072	0.641232319880496	0.552390015251563	0.519787537568579	NA	NA	0.622387975180316	0.696887252519829	NA	NA	p.Ala157Tyr	0	25.8	8.7	11.5	0.695	87.8	99.6	-94.3	-22.9	5.78512396694215	-2.1	0	0	11.64	0	0	0	0	8	6.5879876365377	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-0.717	-4.463	3.746	0.001396552	NA	NA	NA	NA	NA	NA	NA
I158A	158	I	A	missense	low	0.575712323101903	0.175311069284269	6	0.0715704443346945	0.435436829848373	0.715987816355433	0.67850932688333	0.850294871671503	0.456618910575997	0.633164494573619	NA	NA	0.431585830557519	0.404100504349449	0.588675003916653	0.617802065846505	0.641171372975114	0.555148443106789	0.602838893639718	NA	NA	0.574511114193588	0.562541155688773	NA	NA	p.Ile158Ala	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.731	-3.141	1.41	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158C	158	I	C	missense	wt-like	0.847682269561331	0.128236091800407	6	0.0523521652532833	0.745073911152207	0.950290627970456	0.833814569159891	0.990078667190694	0.683430688868203	0.724181618172728	NA	NA	0.985802025116769	0.868786048859702	0.658965756266791	0.650881891403428	0.671394274759671	0.623013930017402	0.632984117441628	NA	NA	0.688516197738958	0.667049621130155	NA	NA	p.Ile158Cys	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.731	-5.106	3.375	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158D	158	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile158Asp	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.731	-4.445	2.714	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158E	158	I	E	missense	low	0.187338555796262	0.381289728203113	6	0.155660879710352	-0.117751162237848	0.492428273830373	0.486263697287222	0.735536729335501	-0.0411965353057584	-0.103836826123399	NA	NA	-0.246942098110681	0.294206367694692	0.486380139070293	0.576853983232554	0.616359311949605	0.406194592999128	0.358741202170458	NA	NA	0.43493447613233	0.537825802008257	NA	NA	p.Ile158Glu	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.731	-4.264	2.533	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158F	158	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile158Phe	1	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.731	-2.693	0.962	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158G	158	I	G	missense	low	0.0456679769106415	0.114113611310687	6	0.0465866867362459	-0.0456402512514502	0.136976205072733	0.156663637975067	0.187153772124474	-0.0527834411883569	-0.0782430526490472	NA	NA	-0.0296870997782788	0.0909040449799905	0.485863870511335	0.506649576054965	0.497792462376267	0.402727616921294	0.367217959057634	NA	NA	0.479624931731939	0.492102809290731	NA	NA	p.Ile158Gly	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.731	-4.124	2.393	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158H	158	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile158His	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.731	-5.268	3.537	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158K	158	I	K	missense	low	-0.000311623723374834	0.319354338293084	6	0.13037586266037	-0.25584361899104	0.25522037154429	0.493494228605761	0.146764936065919	-0.21806481730032	0.00953045077216995	NA	NA	-0.443969938776966	0.0103753982931865	0.435140340490673	0.5783940775088	0.489059920661711	0.353272949480507	0.396288883295633	NA	NA	0.39440484950569	0.473991797685713	NA	NA	p.Ile158Lys	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.731	-4.173	2.442	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158L	158	I	L	missense	wt-like	0.90994152740905	0.0539271527308215	6	0.0220156679119415	0.866791611206051	0.953091443612049	0.82095050979526	0.959624236419897	0.917318884201582	0.950612888883947	NA	NA	0.870886067787093	0.940256577366521	0.674000425379788	0.648141862583421	0.664809668391875	0.692996787073859	0.707979031161439	NA	NA	0.664877402184662	0.683123448574914	NA	NA	p.Ile158Leu	1	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.731	-1.346	-0.385	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158M	158	I	M	missense	possibly_low	0.6944347944391	0.170494027017771	6	0.0696038950643046	0.558013666929358	0.830855921948842	0.677891355212043	0.836640991672157	0.748043002559323	0.775417067724856	NA	NA	0.766232585657262	0.36238376380896	0.640283073534092	0.617670438640715	0.63821924341914	0.642346903649044	0.649953496743738	NA	NA	0.643349649855062	0.55315899911298	NA	NA	p.Ile158Met	1	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.731	-2.584	0.853	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158N	158	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile158Asn	1	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.731	-4.548	2.817	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158P	158	I	P	missense	low	-0.0405600262386365	0.12229918046704	6	0.0499284313508007	-0.138417953490786	0.0572979010135133	0.0674700564455727	0.129188069461581	-0.114667548596964	-0.171163982207061	NA	NA	-0.144479737805214	-0.00970701472973485	0.462743368456527	0.487651452910231	0.485259595229925	0.38421096354052	0.336442187349603	NA	NA	0.456011503583991	0.469475233329063	NA	NA	p.Ile158Pro	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.731	-4.503	2.772	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158Q	158	I	Q	missense	possibly_low	0.714449157329775	0.169623345748647	6	0.0692484409246459	0.578724707131919	0.85017360752763	0.623020512881219	0.880800953106972	0.782488316983629	0.520257068229119	NA	NA	0.560932613730975	0.919195479046734	0.626875081773933	0.605983016723348	0.647767146824517	0.652653458506099	0.565443516797838	NA	NA	0.601118403851989	0.678386776449185	NA	NA	p.Ile158Gln	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.731	-4.572	2.841	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158R	158	I	R	missense	low	0.251980545519592	0.0835922225206338	6	0.0341263819401236	0.185094065994292	0.318867025044892	0.352227955625129	0.357924141977162	0.166182567026363	0.225816918310724	NA	NA	0.180583228149166	0.229148462029009	0.523036394049982	0.54830453514194	0.534715026229971	0.468245531715033	0.467923798918676	NA	NA	0.522878605186113	0.523194182913851	NA	NA	p.Ile158Arg	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.731	-4.457	2.726	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158S	158	I	S	missense	low	0.327438548033135	0.0802014059187895	6	0.0327420868591442	0.263265237010531	0.39161185905574	0.456761803800623	0.337873537684927	0.277998637857148	0.314424820621603	NA	NA	0.219050058926016	0.358522429308495	0.530585638534474	0.570570116211518	0.530379849595265	0.501702577678433	0.49727107930016	NA	NA	0.530791427473682	0.552290579279467	NA	NA	p.Ile158Ser	1	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.731	-4.021	2.29	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158T	158	I	T	missense	wt-like	1.0314974521081	0.175630614166788	6	0.0717008979867095	0.890966274394968	1.17202862982123	1.21604108058124	1.19215615198074	1.03489777768669	1.01455750854042	NA	NA	1.00542373336784	0.725908460491663	0.721631980684233	0.732295668142104	0.715085805333697	0.728178156034768	0.729157736818658	NA	NA	0.692552482694948	0.634916240432792	NA	NA	p.Ile158Thr	1	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.731	-3.852	2.121	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158V	158	I	V	missense	wt-like	1.23773187399599	0.0886639109550659	6	0.0361968900732458	1.16678727310008	1.30867647489191	1.18516282276455	1.08297616808055	1.25280424587471	1.30728789078969	NA	NA	1.29985355154692	1.29830656491954	0.75838380503898	0.725718637211886	0.691479807814464	0.793379040556294	0.826111173024693	NA	NA	0.7531181903543	0.763649419723659	NA	NA	p.Ile158Val	1	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.731	-2.029	0.298	0.005538006	NA	NA	NA	NA	8.13e-06	NA	NA
I158W	158	I	W	missense	low	0.515824069228999	0.106453032141931	6	0.0434592683866379	0.430645468396729	0.60100267006127	0.416785302901707	0.500628845356139	0.494078044283494	0.516025957536532	NA	NA	0.447825517367599	0.719600747928525	0.565963120290578	0.562055170696946	0.565569462671605	0.566356777909551	0.564042156551381	NA	NA	0.577851700177378	0.633497626558944	NA	NA	p.Ile158Trp	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.731	-3.452	1.721	0.005538006	NA	NA	NA	NA	NA	NA	NA
I158X	158	I	X	nonsense	low	-0.0415011092353965	0.221059389136833	6	0.0902471177060981	-0.218382209647896	0.135379991177103	0.0169830574712523	0.363760488490718	-0.0809568823099396	-0.155552732521087	NA	NA	-0.280257766827751	-0.112982819715571	0.437164813118885	0.476897784235035	0.535976913037413	0.394297700653011	0.341612693700518	NA	NA	0.428081274019605	0.446248352218164	NA	NA	p.Ile158Ter	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I158Y	158	I	Y	missense	low	0.590202648257135	0.138101133358338	6	0.0563795516046635	0.479700757647477	0.700704538866793	0.49233102342069	0.844917566512128	0.601602983622403	0.581765555218463	NA	NA	0.447327743810236	0.573271016958888	0.59217260941634	0.578146316235291	0.640008736311159	0.598529852950954	0.585815365881726	NA	NA	0.577749305630717	0.600587853890624	NA	NA	p.Ile158Tyr	0	25.4	10.3	8.1	0.296	91	-93.5	-62.5	140.2	5.23560209424084	-2.2	0	0	14.09	0	0	0	0	5	7.97732349789593	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.731	-4.24	2.509	0.005538006	NA	NA	NA	NA	NA	NA	NA
N159A	159	N	A	missense	possibly_low	0.590382444830717	0.384978490338047	6	0.157166810545866	0.282341156595789	0.898423733065645	0.810026404234938	0.798100109766145	0.551117899134107	1.09030037811022	NA	NA	0.190574020436361	0.102175857302535	0.606655104694432	0.645815041537308	0.629886251141965	0.583423958246899	0.754244068536164	NA	NA	0.524933761857043	0.494637856533945	NA	NA	p.Asn159Ala	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.883	-3.024	1.141	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159C	159	N	C	missense	wt-like	0.990378684045978	0.075090107166965	4	0.0375450535834825	0.916791731224726	1.06396563686723	0.980714610925421	0.935130843257848	NA	NA	NA	NA	1.09919914871943	0.946470133281211	0.683346153035274	0.682171419591118	0.65951390851386	NA	NA	NA	NA	0.71184256148841	0.684520886479429	NA	NA	p.Asn159Cys	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.883	-5.447	3.564	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159D	159	N	D	missense	possibly_wt-like	0.778554648711631	0.0908650750230125	6	0.0370955115410155	0.705848782103151	0.851260515320112	0.630484324485105	0.759618446671431	0.79403068881959	0.819417585401174	NA	NA	0.759841249410519	0.90793559748197	0.649071014442916	0.607572799413404	0.621566062668771	0.656107109329036	0.664526638591142	NA	NA	0.642034919556796	0.675854412451021	NA	NA	p.Asn159Asp	1	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.883	-2.875	0.992	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159E	159	N	E	missense	possibly_wt-like	0.738603437071921	0.11889661138049	6	0.0485393383380315	0.643468082095975	0.833738792047867	0.627812391731043	0.854591670544083	0.749357504380123	0.598220160600332	NA	NA	0.89406459961065	0.707574295565293	0.636446625559265	0.607003681023654	0.642100391462783	0.642740222315232	0.591265194905035	NA	NA	0.669645343798323	0.630792859655747	NA	NA	p.Asn159Glu	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.883	-2.997	1.114	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159F	159	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn159Phe	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.883	-4.707	2.824	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159G	159	N	G	missense	possibly_low	0.709087881203642	0.11273183296544	6	0.0460225780889987	0.618885285673522	0.799290476733762	0.801089143729199	0.882533965144102	0.676849927835568	0.691130906756509	NA	NA	0.586197104377111	0.616726239379362	0.621541230708278	0.643911416043713	0.648141844423728	0.621044867585614	0.622037593830943	NA	NA	0.606315437780481	0.610360997609489	NA	NA	p.Asn159Gly	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.883	-2.916	1.033	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159H	159	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn159His	1	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.883	-3.607	1.724	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159I	159	N	I	missense	low	0.319759971443294	0.248547122828901	6	0.101468937994611	0.120884507424329	0.518635435462259	0.46974138960086	0.584790746290495	0.328618905572158	0.498368851286161	NA	NA	-0.0180308996689762	0.0550708355790635	0.53752148790789	0.573334752020195	0.583766256201879	0.516848921232069	0.558194054583712	NA	NA	0.482022671242852	0.484043867559979	NA	NA	p.Asn159Ile	1	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.883	-4.316	2.433	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159K	159	N	K	missense	possibly_low	0.703704144530429	0.221104166298791	6	0.090265397905919	0.526787215584651	0.880621073476208	0.677173823485277	1.14547617029861	0.59363096539141	0.542494970040528	NA	NA	0.638873979390862	0.624574958575891	0.614638762213501	0.617517605265582	0.704993043891328	0.596144505492457	0.572808795994558	NA	NA	0.617151338275283	0.612126186151719	NA	NA	p.Asn159Lys	1	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.883	-2.898	1.015	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159L	159	N	L	missense	low	0.499544249452778	0.236716464903325	6	0.0966390921214316	0.310135109396124	0.688953389509433	0.652196399672211	0.831586223526503	0.442596931749944	0.590789194630608	NA	NA	0.253723461365535	0.226373285771867	0.569878443435138	0.612197444719255	0.637126343053669	0.550952856670998	0.588804030199278	NA	NA	0.537923922302822	0.522570041673845	NA	NA	p.Asn159Leu	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.883	-3.07	1.187	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159M	159	N	M	missense	low	0.477724063734568	0.152864253197526	6	0.062406570040925	0.355409434055678	0.600038693413457	0.344894449645602	0.778191882039848	0.402277519411967	0.462842200961449	NA	NA	0.436752912079934	0.441385418268605	0.558834547649929	0.546742507389577	0.625581857996524	0.53888868358938	0.546427490418404	NA	NA	0.57557400908268	0.570926587910281	NA	NA	p.Asn159Met	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.883	-3.688	1.805	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159P	159	N	P	missense	low	0.443516442605076	0.244725769039886	6	0.0999088768429876	0.247698642256972	0.639334242953179	0.187273199750018	0.797513369276716	0.62881798303371	0.526993377025882	NA	NA	0.260997164874759	0.25950356166937	0.553547384191158	0.513169375058827	0.629759390942475	0.606672989080071	0.567674608357835	NA	NA	0.53942016002448	0.530021089666627	NA	NA	p.Asn159Pro	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.883	-1.438	-0.445	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159Q	159	N	Q	missense	low	0.420128119071406	0.329636445034546	6	0.134573515159939	0.156368876084972	0.683887362057841	0.688211085425363	0.899113277284306	0.144884079304128	0.14804617084681	NA	NA	0.130165832813672	0.510348268754158	0.549471962995066	0.619868528481387	0.651726486839595	0.461872704648412	0.442165826189636	NA	NA	0.512507491126672	0.586436434863459	NA	NA	p.Asn159Gln	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.883	-3.381	1.498	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159R	159	N	R	missense	possibly_wt-like	0.769759614752112	0.0625312537815682	6	0.0255282774568872	0.719725110349267	0.819794119154956	0.697042400988687	0.773211435182273	0.787269979315653	0.7117376204999	NA	NA	0.776938493170032	0.872357759356124	0.637207263289704	0.621749587832575	0.624505026768265	0.654084203614877	0.628862617222723	NA	NA	0.645551909356686	0.667852904097296	NA	NA	p.Asn159Arg	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.883	-3.536	1.653	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159S	159	N	S	missense	wt-like	0.868596031033275	0.179965555729881	6	0.0734706304691028	0.724596241392382	1.01259582067417	0.65154959654974	1.02152109095599	0.851873671173863	0.652022958031604	NA	NA	1.01337597230525	1.02123289718321	0.675803547152939	0.61205967644983	0.678192496841117	0.67341459746476	0.609084889766832	NA	NA	0.694188298597357	0.701335142528191	NA	NA	p.Asn159Ser	1	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.883	-2.848	0.965	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159T	159	N	T	missense	possibly_low	0.600375638186427	0.280873051919293	6	0.114665943283419	0.375634519097613	0.825116757275241	0.900640864713494	0.873898870410258	0.593277402853655	0.676072469338603	NA	NA	0.18600691969221	0.372357302110343	0.606544447660335	0.665115810150305	0.646274835311034	0.59603871427668	0.61705018104399	NA	NA	0.523994286058594	0.555402062610892	NA	NA	p.Asn159Thr	1	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.883	-3.34	1.457	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159V	159	N	V	missense	low	0.608926571583529	0.11294694443597	6	0.0461103969791017	0.518551854191645	0.699301288975413	0.685582815857781	0.760962055756771	0.569435433852481	0.58785876537825	NA	NA	0.428277639441717	0.621442719214173	0.600163290171842	0.619308710296645	0.621856566766705	0.588904839451679	0.587833460682743	NA	NA	0.573830602493924	0.611421740892004	NA	NA	p.Asn159Val	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.883	-3.961	2.078	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159W	159	N	W	missense	possibly_low	0.596881385962094	0.274893238867745	6	0.112224694827831	0.376925025923546	0.816837746000642	0.938586533472263	0.94482332173507	0.451304234847337	0.417616938297935	NA	NA	0.314140476778355	0.514816810641605	0.570499814464148	0.673198190917244	0.661609536436811	0.553558212392964	0.531448708288388	NA	NA	0.550352008954419	0.587441416535333	NA	NA	p.Asn159Trp	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.883	-5.846	3.963	0.004044555	NA	NA	NA	NA	NA	NA	NA
N159X	159	N	X	nonsense	low	-0.00636238267073225	0.338335239065698	6	0.138124782952254	-0.277081982629561	0.264357217288097	-0.445802193994795	-0.325852230032957	0.357919181387123	0.183178909595303	NA	NA	-0.112987374315095	0.305369411336027	0.458145783937394	0.37832509496578	0.386874526856595	0.525616003346456	0.453801925315468	NA	NA	0.462489642559319	0.540336387014383	NA	NA	p.Asn159Ter	0	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N159Y	159	N	Y	missense	possibly_wt-like	0.755947846490634	0.210307140262338	6	0.0858575304844432	0.587670178939576	0.924225514041693	0.680574397625197	0.858152991131436	1.00507235803932	0.726901355856795	NA	NA	0.868744435623806	0.396241540667252	0.638377647991885	0.618241923374185	0.642870390888934	0.71925394300702	0.633884905094837	NA	NA	0.664436857581138	0.560773663146582	NA	NA	p.Asn159Tyr	1	26.1	8.2	5	0.375	38.8	-121.2	-51.1	129.9	9.62566844919786	-2.7	0	0	13.65	1	135	0	0	6	11.115396333223	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.883	-4.637	2.754	0.004044555	NA	NA	NA	NA	NA	NA	NA
P160A	160	P	A	missense	possibly_wt-like	0.86091235683791	0.256867470324067	6	0.104865705635577	0.655379350578799	1.06644536309702	0.687492518833256	1.11580156878557	1.02039720075513	0.83031578853005	NA	NA	0.450475608185497	1.06099145593796	0.683356605729135	0.619715474681209	0.698577045787304	0.723839365865425	0.668136165670966	NA	NA	0.578396837306288	0.710276901127545	NA	NA	p.Pro160Ala	1	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.813	-2.257	0.444	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160C	160	P	C	missense	possibly_low	0.68428496922756	0.209160804375881	6	0.0853895408184998	0.516924544566888	0.851645393888233	0.86573545309984	0.985805412036299	0.723559071896462	0.474817231317748	NA	NA	0.544753807319727	0.511038839695286	0.61640564276936	0.657681000415318	0.670470346700972	0.635020944263548	0.550393666845988	NA	NA	0.597790341275172	0.586591745288301	NA	NA	p.Pro160Cys	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.813	-5.521	3.708	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160D	160	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro160Asp	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.813	-2.809	0.996	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160E	160	P	E	missense	possibly_low	0.677351262868165	0.294670343184268	6	0.120298663855377	0.441570214323335	0.913132311412995	0.983289099033784	1.10818411381665	0.607118536085773	0.447850568253971	NA	NA	0.42854929998311	0.489115960035704	0.590920723131844	0.682719782391206	0.696930062368955	0.600180188997548	0.541462203610248	NA	NA	0.573886484445808	0.58166125726614	NA	NA	p.Pro160Glu	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.813	-2.259	0.446	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160F	160	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro160Phe	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.813	-4.086	2.273	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160G	160	P	G	missense	possibly_low	0.572747723377877	0.199161436210214	6	0.0813073158591477	0.413388312614325	0.732107134141429	0.754926381219218	0.854758671508526	0.56567276322268	0.521552425021899	NA	NA	0.353191692039636	0.386384407255303	0.576825767965996	0.634078804415983	0.642136499036823	0.587778991948086	0.565872543983906	NA	NA	0.558385042095847	0.558556779280268	NA	NA	p.Pro160Gly	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.813	-3.539	1.726	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160H	160	P	H	missense	wt-like	0.885922516736159	0.173673382398939	6	0.0709018614634434	0.746957421830962	1.02488761164136	0.545736987552443	0.930359293504739	0.957795542722136	1.04677508161412	NA	NA	0.910870621462394	0.923997573561124	0.67628460118681	0.589521720898269	0.658482243298212	0.70510801057246	0.739828321783954	NA	NA	0.673102427774003	0.679466774599617	NA	NA	p.Pro160His	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.813	-3.629	1.816	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160I	160	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro160Ile	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.813	-3.841	2.028	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160K	160	P	K	missense	possibly_wt-like	0.787573199107661	0.125898520857822	6	0.0513978559121349	0.686835252637298	0.888311145578025	0.902084586942604	0.900141461222871	0.738041554849238	0.566271643129349	NA	NA	0.832717625063927	0.786182323437978	0.650210356780258	0.665423321209118	0.651948792308382	0.639354320442975	0.580683722197284	NA	NA	0.657025959833881	0.648471921252135	NA	NA	p.Pro160Lys	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.813	-2.804	0.991	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160L	160	P	L	missense	low	0.510293028456249	0.114530974551495	6	0.0467570745658082	0.418650846284811	0.601935210627686	0.506938402192681	0.70257204273469	0.546344821699542	0.509780989263611	NA	NA	0.430558482656343	0.365563432190627	0.577778726730827	0.58125766994453	0.609231958726762	0.581995781868239	0.561973798875607	NA	NA	0.574299783517124	0.553874111229348	NA	NA	p.Pro160Leu	1	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.813	-3.102	1.289	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160M	160	P	M	missense	low	0.512967374862358	0.126518536208491	6	0.0516509761191066	0.411733321902571	0.614201427822145	0.50316449675948	0.748376931996268	0.448884877911531	0.486817699568201	NA	NA	0.372590907911246	0.517969335027422	0.571414695985036	0.580453832729709	0.619135514888357	0.552834304500281	0.554368268402625	NA	NA	0.562375559240364	0.588150423926935	NA	NA	p.Pro160Met	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.813	-5.125	3.312	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160N	160	P	N	missense	low	0.266015324214751	0.192747297014424	4	0.0963736485072121	0.0771264440818932	0.454904204347609	0.193155358653517	0.522360922957329	NA	NA	NA	NA	0.0656460095887342	0.282899005659424	0.524852513625748	0.514422267669363	0.570268193625902	NA	NA	NA	NA	0.499235436088762	0.535282759582133	NA	NA	p.Pro160Asn	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.813	-3.348	1.535	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160P	160	P	P	synonymous	possibly_low	0.5872316917207	0.228257453480828	6	0.0931857151691827	0.404591046115494	0.769872337325906	0.528317635934558	0.375097195137639	0.41558275328805	0.455254174089934	NA	NA	0.878331432937075	0.870806958936945	0.564862863482871	0.58581142043199	0.538428042442489	0.542869809182852	0.543914306533751	NA	NA	0.666408951576907	0.667504126792021	NA	NA	p.Pro160=	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160Q	160	P	Q	missense	low	0.554796553044371	0.0892385744993487	6	0.0364314954827912	0.483392133995167	0.626200972093576	0.435028405248535	0.66509691513012	0.636061551924177	0.520684095340047	NA	NA	0.486815053525264	0.585093297098084	0.59350072034361	0.565940929055158	0.601129395073014	0.608840373566995	0.56558494983065	NA	NA	0.585872045614207	0.603246702159011	NA	NA	p.Pro160Gln	1	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.813	-3.059	1.246	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160R	160	P	R	missense	low	0.632544436321852	0.0954923011693891	6	0.0389845687048634	0.556136085707492	0.708952786936212	0.583579617055116	0.774320804804237	0.663212622275184	0.67271521580934	NA	NA	0.490924400378403	0.610513957608832	0.612451045967968	0.597582154430413	0.624744885537322	0.616964381162145	0.615938245674058	NA	NA	0.58671735911444	0.608963846261878	NA	NA	p.Pro160Arg	1	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.813	-3.039	1.226	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160S	160	P	S	missense	possibly_low	0.682201657497341	0.152027417390708	6	0.0620649332533928	0.560556623617808	0.803846691376873	0.796558521438612	0.923032464280962	0.620374734323088	0.576549810367723	NA	NA	0.66542674895056	0.5112676656231	0.61338001005289	0.64294639906914	0.6568980965865	0.604146642392221	0.58408789098907	NA	NA	0.622613377713559	0.586643208577511	NA	NA	p.Pro160Ser	1	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.813	-2.894	1.081	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160T	160	P	T	missense	possibly_low	0.540545657463941	0.260722627038596	6	0.106439566773754	0.331927940057337	0.749163374870545	0.691425929153455	0.984681261319189	0.536543729734495	0.338907035342117	NA	NA	0.386964130207713	0.304751859026681	0.572197676054747	0.620553286240746	0.670227292085177	0.579063148107012	0.505379683623528	NA	NA	0.565332204002482	0.5401974985877	NA	NA	p.Pro160Thr	1	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.813	-2.809	0.996	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160V	160	P	V	missense	low	0.507366236629442	0.239995950294828	6	0.0979779364261136	0.315333009954704	0.699399463304179	0.847381190218813	0.749217900530504	0.418649975519415	0.4661758694838	NA	NA	0.314452444757551	0.248320039266567	0.548973898346755	0.653771565000066	0.619317342183285	0.543787568091856	0.547531614342714	NA	NA	0.550416182350795	0.527505898956793	NA	NA	p.Pro160Val	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.813	-2.83	1.017	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160W	160	P	W	missense	possibly_wt-like	0.758785227049767	0.10040070408989	6	0.0409884158060658	0.678449408286526	0.839121045813009	0.733074178197658	0.901086668378577	0.811401153570013	0.718104886478435	NA	NA	0.6028490158098	0.786195459864121	0.639723178012988	0.629424312053771	0.652153157220115	0.661304612990563	0.630971480372196	NA	NA	0.609740820460941	0.648474875653781	NA	NA	p.Pro160Trp	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.813	-4.499	2.686	0.008033663	NA	NA	NA	NA	NA	NA	NA
P160X	160	P	X	nonsense	low	-0.205219434796362	0.146364005531062	6	0.0597528550434995	-0.322332878655064	-0.0881059909376607	-0.128061181509475	-0.162717822428237	-0.167820423208131	-0.0708965149476038	NA	NA	-0.48776667913706	-0.214053987547666	0.403770871785528	0.446003539757601	0.422146105800397	0.368306826006982	0.369651160793987	NA	NA	0.385395637770659	0.423517297260057	NA	NA	p.Pro160Ter	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P160Y	160	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro160Tyr	0	29.8	8.8	4.1	0.86	112.3	53.3	-48.8	-41.6	5.84415584415584	-1.8	0	0	13.97	0	0	0	0	6	14.0242730879225	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.813	-4.059	2.246	0.008033663	NA	NA	NA	NA	NA	NA	NA
G161A	161	G	A	missense	wt-like	1.03088715642595	0.15381306001175	6	0.0627939188008125	0.907813337128228	1.15396097572368	0.813040241941702	0.893897424246734	1.13893596751543	1.22878964985323	NA	NA	1.05945241510073	1.05120723989789	0.705871436588699	0.646456985261391	0.650598758024594	0.759307943311203	0.800112251640312	NA	NA	0.70366645669151	0.708076416485888	NA	NA	p.Gly161Ala	1	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-2.653	-2.3	-0.353	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161C	161	G	C	missense	possibly_low	0.596787516232948	0.457865767270771	8	0.161879994455172	0.279508557283268	0.914066475182629	1.19529125537704	0.792401336454139	0.653178895620546	0.366070754711668	-0.376215349325442	0.655897785137077	0.846622922093874	0.641052529794684	0.614897077936383	0.727875980898904	0.628654109279873	0.613962139611586	0.514376412670846	0.450978123690133	0.606031269770669	0.659886349994228	0.61583201626118	NA	NA	p.Gly161Cys	1	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-2.653	-3.45	0.797	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161D	161	G	D	missense	wt-like	1.00415358032226	0.208604382203217	6	0.0851623824177334	0.837238377945879	1.17106878269865	0.746380030887621	0.794632033518001	1.14136777958764	1.16833453525273	NA	NA	0.932688619776798	1.24151848291079	0.714234098463822	0.632258442308604	0.629136412239396	0.760035577967561	0.780089283570815	NA	NA	0.677590500740916	0.750877696186728	NA	NA	p.Gly161Asp	1	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-2.653	-2.357	-0.296	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161E	161	G	E	missense	possibly_wt-like	0.788568184511324	0.157423578767716	6	0.0642679069106235	0.66260540160473	0.914530967417919	0.889050054097706	0.864631138603583	0.885945018628122	0.541497452518045	NA	NA	0.911418280902511	0.63886716231798	0.653459012182429	0.662646981747521	0.644271042617336	0.683609255793769	0.572478414328202	NA	NA	0.673215084099888	0.61534052388722	NA	NA	p.Gly161Glu	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-2.653	-2.211	-0.442	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161F	161	G	F	missense	possibly_wt-like	0.864651032612675	0.21629175365884	6	0.0883007386726523	0.691584765005993	1.03771730021936	0.816175895848955	1.0836749549641	0.937974308033167	1.10045140667391	NA	NA	0.68633048157475	0.563299148581167	0.669377884724713	0.647124875686326	0.691630893763099	0.699177199776543	0.757606128506548	NA	NA	0.626913381588629	0.59834516596101	NA	NA	p.Gly161Phe	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-2.653	-3.967	1.314	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161G	161	G	G	synonymous	wt-like	0.999327890428042	0.0527486651865052	6	0.0215345523866414	0.957120943327033	1.04153483752905	0.941583139529154	1.03883482234589	1.0151161647214	1.02390146955057	NA	NA	0.925341364380737	1.05119038204049	0.695004277235707	0.673836464321102	0.681935929342559	0.722259200653018	0.732252492889924	NA	NA	0.676079133022902	0.708072625128856	NA	NA	p.Gly161=	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161H	161	G	H	missense	wt-like	1.10856852348805	0.0684564703003006	6	0.0279472369712879	1.05379294555692	1.16334410141918	1.05826043393293	1.13351733314036	1.15240549873289	1.21164837154831	NA	NA	1.06088251693377	1.03469698664002	0.70416193601653	0.698688584499103	0.702407402547504	0.763338229134158	0.794434993885729	NA	NA	0.7039606358955	0.704363236137559	NA	NA	p.Gly161His	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-2.653	-3.392	0.739	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161I	161	G	I	missense	possibly_wt-like	0.782772079040756	0.125139098322929	6	0.0510878229605249	0.682641785989568	0.882902372091943	0.913388993737813	0.922887796537065	0.657684767678805	0.648632878011049	NA	NA	0.839865740764019	0.714172297515783	0.644571788879625	0.667831145950436	0.656866817717594	0.615310364132787	0.607962082135862	NA	NA	0.658496363505916	0.632276760041656	NA	NA	p.Gly161Ile	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-2.653	-4.442	1.789	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161K	161	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly161Lys	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-2.653	-3.012	0.359	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161L	161	G	L	missense	wt-like	0.892780361026494	0.0864732613835985	6	0.0353025611306889	0.823588612648321	0.961972109404668	0.905342336359924	0.775009935530581	0.939582074213753	0.985187674138056	NA	NA	0.798149805461516	0.953410340455136	0.676099483576565	0.666117217827502	0.624893883711121	0.699658267539009	0.719430333929243	NA	NA	0.649915183930106	0.686081749325628	NA	NA	p.Gly161Leu	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-2.653	-3.215	0.562	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161M	161	G	M	missense	wt-like	1.21142022719035	0.137622411866865	3	0.0794563365378602	1.05568866923265	1.36715178514805	1.2023196757056	1.35336705754767	NA	NA	NA	NA	NA	1.07857394831778	0.729373025782911	0.729373025782911	0.749941500498162	NA	NA	NA	NA	NA	0.714231229638422	NA	NA	p.Gly161Met	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-2.653	-4.384	1.731	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161N	161	G	N	missense	wt-like	1.16956440404796	0.258365891843361	5	0.115544739445823	0.943100876131083	1.39602793196484	0.746017329385083	NA	1.32215637676964	1.33325334480958	NA	NA	1.34926932463924	1.09712564463626	0.763283265635671	0.632181187334739	NA	0.814130238606552	0.834711031947893	NA	NA	0.763283265635671	0.718403533546912	NA	NA	p.Gly161Asn	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-2.653	-2.848	0.195	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161P	161	G	P	missense	wt-like	1.11775948008245	0.165764328473796	6	0.0676730037193175	0.985122830066947	1.25039613009796	0.933788697206932	1.09051067338607	1.11795850055747	1.30047738198961	NA	NA	0.946148970471965	1.31767265688268	0.723070013506407	0.672176257694763	0.693108856539303	0.753031170473511	0.823855506136255	NA	NA	0.680359363182355	0.768004882415743	NA	NA	p.Gly161Pro	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-2.653	-2.64	-0.013	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161Q	161	G	Q	missense	wt-like	1.16557242920068	0.203210336973499	6	0.0829602726740165	1.00297328261199	1.32817157578938	0.974393531890806	1.14671798039107	1.32476205346376	1.31197666956359	NA	NA	0.874660621367243	1.36092371852763	0.741496823961729	0.68082503753259	0.705261537848872	0.814909896166267	0.82766411471201	NA	NA	0.665653847009761	0.777732110074586	NA	NA	p.Gly161Gln	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-2.653	-2.838	0.185	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161R	161	G	R	missense	wt-like	1.02017669190262	0.0418698295486518	6	0.0170932863352504	0.986674466308101	1.05367891749714	0.966819039315203	1.02884506327195	1.04969411334279	1.0636006561984	NA	NA	0.969395327396708	1.0427059518907	0.6956528605088	0.679211679931711	0.679776025855736	0.732605441651744	0.745401017243687	NA	NA	0.685141256763502	0.706164464254099	NA	NA	p.Gly161Arg	1	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-2.653	-3.334	0.681	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161S	161	G	S	missense	possibly_low	0.687257560161661	0.200350667275364	6	0.0817928174084615	0.526946583847016	0.847568536476306	0.761714445777576	0.813224830911828	0.769071125989005	0.284288825872288	NA	NA	0.709379640215551	0.785866492203719	0.634340523840767	0.635524653816609	0.633156393864925	0.648638833663072	0.487289921136861	NA	NA	0.631654710482103	0.648400890340972	NA	NA	p.Gly161Ser	1	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-2.653	-2.457	-0.196	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161T	161	G	T	missense	wt-like	1.0755568418998	0.179247249488716	6	0.073177383174118	0.932131806395644	1.21898187740396	0.822733759963697	0.871909485885776	1.22903399471262	1.20275928279193	NA	NA	1.15756932213442	1.16933520591036	0.729246586453665	0.648521692675642	0.645844706962667	0.786266624784727	0.79149089326642	NA	NA	0.723849602354522	0.734643570552809	NA	NA	p.Gly161Thr	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-2.653	-2.903	0.25	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161V	161	G	V	missense	wt-like	1.15990526502424	0.10802210847658	6	0.0440998411178656	1.07347116470928	1.24633936533919	0.965218272599344	1.22983042185116	1.14411497498083	1.19718815890012	NA	NA	1.2770368750051	1.14604288680888	0.738914888892694	0.678870718590409	0.723231425889137	0.760857580045237	0.789645715459147	NA	NA	0.748424684208298	0.729405093577089	NA	NA	p.Gly161Val	1	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-2.653	-3.479	0.826	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161W	161	G	W	missense	wt-like	0.842830596395355	0.0871121357788021	6	0.0355633805103519	0.773127651426571	0.912533541364138	0.79861874370861	0.897889946578787	0.788754958602397	0.719424947094679	NA	NA	0.904701486445277	0.947593495942378	0.652995260019771	0.643385223878278	0.651461988343002	0.65452853169654	0.631408689560261	NA	NA	0.671833405396214	0.684773532401471	NA	NA	p.Gly161Trp	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-2.653	-5.949	3.296	0.009152198	NA	NA	NA	NA	NA	NA	NA
G161X	161	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly161Ter	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G161Y	161	G	Y	missense	wt-like	0.932166261517113	0.158948424421864	6	0.0648904225421507	0.804983370392911	1.05934915264131	0.901321598901929	0.882608675803186	1.18384670121277	0.872865065238894	NA	NA	1.03395380983764	0.718401718108255	0.673744728292509	0.66526080569504	0.648157997747534	0.772745908626902	0.682228650889979	NA	NA	0.698421264198316	0.633227962981036	NA	NA	p.Gly161Tyr	0	28.9	10.1	0.6	0.708	104.4	58.1	-62.7	-23.6	67.0103092783505	-1.5	0	0	13.54	0	0	0	0	5	16.0661145161059	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-2.653	-4.772	2.119	0.009152198	NA	NA	NA	NA	NA	NA	NA
D162A	162	D	A	missense	wt-like	0.874701624706537	0.0565971386883931	6	0.0231056851146827	0.829415314043635	0.919987935369438	0.861621950815011	0.949261684942248	0.940525340663308	0.848702811896011	NA	NA	0.832587697599811	0.81551026232283	0.659784197947488	0.656804829488854	0.66256916279977	0.699940507012495	0.674226019013939	NA	NA	0.656999233095206	0.65506781803357	NA	NA	p.Asp162Ala	1	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.902	-3.037	1.135	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162C	162	D	C	missense	possibly_wt-like	0.883555452058969	0.237685724085624	6	0.0970347905256213	0.693370757381363	1.07374014673657	1.06712448532475	0.698732196331068	0.898184579252534	1.09760285021513	NA	NA	0.502707126682631	1.0369814745477	0.693924066251796	0.700576616541492	0.608401738741009	0.687271515962099	0.756662675576301	NA	NA	0.589141125705696	0.704877020842875	NA	NA	p.Asp162Cys	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.902	-5.333	3.431	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162E	162	D	E	missense	wt-like	1.06937759551568	0.123914720422485	6	0.0505879727757872	0.970226990824249	1.16852820020712	0.898073546077881	1.00616160173772	1.10636823547379	1.21209291568741	NA	NA	1.19727017968863	0.996299094428673	0.713871881833047	0.664568974439094	0.674871594497749	0.749563189272314	0.794582228626109	NA	NA	0.732016270212161	0.695727493453932	NA	NA	p.Asp162Glu	1	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.902	-2.601	0.699	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162F	162	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Phe	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.902	-4.44	2.538	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162G	162	D	G	missense	possibly_wt-like	0.72276610204091	0.100811453832434	6	0.041156103686268	0.642101621071828	0.803430583009991	0.725767878555081	0.881680070532013	0.656261976003556	0.80026664905209	NA	NA	0.645627849710817	0.626992188391903	0.623204361444884	0.627868079217711	0.647957222358634	0.614884643517481	0.658183774309888	NA	NA	0.618540643672057	0.612669824708319	NA	NA	p.Asp162Gly	1	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.902	-3.936	2.034	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162H	162	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162His	1	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.902	-5.107	3.205	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162I	162	D	I	missense	possibly_low	0.337326505795533	0.837090894673573	4	0.418545447336786	-0.483007496877774	1.15766050846884	1.12280482568741	0.912234374239672	-0.0042348127596616	NA	NA	NA	NA	-0.681498363985285	0.535908758675303	0.712436460543839	0.65456342243084	0.417254094919765	NA	NA	NA	NA	0.318388366442582	NA	NA	p.Asp162Ile	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.902	-2.959	1.057	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162K	162	D	K	missense	possibly_low	0.689162315218153	0.207541582524644	6	0.0847284962658507	0.52309751407285	0.855227116363457	0.782221937433408	1.02196218751632	0.563863741938854	0.582519350201731	NA	NA	0.43396751188237	0.750439162336233	0.613565214975711	0.639892724312111	0.678287867108973	0.587237705639311	0.586065025699273	NA	NA	0.575001038127756	0.640433231516898	NA	NA	p.Asp162Lys	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.902	-3.515	1.613	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162L	162	D	L	missense	wt-like	0.940754592390426	0.099969525023047	6	0.0408123876891433	0.860763782396619	1.02074540238423	0.835050765893047	1.04198802882434	0.846061665589697	0.885082663638545	NA	NA	1.06557965870011	0.97076477169682	0.684446428243956	0.651145199786889	0.682617689695041	0.671675558196753	0.686275166792871	NA	NA	0.704926861792096	0.689984786549624	NA	NA	p.Asp162Leu	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.902	-1.988	0.086	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162M	162	D	M	missense	wt-like	0.971701047514775	0.123027031952125	6	0.0502255754752979	0.873260728480392	1.07014136654916	0.88661455251037	0.957186876801469	0.824256954238869	1.03641853098623	NA	NA	0.949555044991774	1.17617432555994	0.673105635710267	0.662128222905439	0.664282682555729	0.665151261425609	0.736398192110017	NA	NA	0.681060009994925	0.736181698665447	NA	NA	p.Asp162Met	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.902	-1.894	-0.008	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162N	162	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Asn	1	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.902	-3.305	1.403	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162P	162	D	P	missense	low	-0.0870200943750133	0.192016617992362	6	0.0783904560360343	-0.240662564937311	0.0666223761872845	0.130447993787382	0.0946646614571896	-0.145921829224589	-0.302830508381934	NA	NA	0.00285146380695439	-0.301332347695083	0.440841746610274	0.501065676092035	0.477795228094167	0.37485921387035	0.292833723998862	NA	NA	0.486318279375688	0.40388826512638	NA	NA	p.Asp162Pro	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.902	-4.347	2.445	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162Q	162	D	Q	missense	wt-like	0.920886681704311	0.153000879003932	6	0.0624623472928237	0.798462730620543	1.04331063278808	1.08606936303625	1.09885914227545	0.84993511757811	0.957617365327997	NA	NA	0.721791233529874	0.811047868478177	0.683874223457928	0.704611852189093	0.694913893770966	0.672834553144889	0.710298940884703	NA	NA	0.634207838208469	0.654064219065603	NA	NA	p.Asp162Gln	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.902	-3.088	1.186	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162R	162	D	R	missense	wt-like	0.835920409341385	0.105694485331504	6	0.0431495929480444	0.751348761215654	0.920492057467115	0.864765664485487	1.01024294048109	0.735042474253716	0.869680512838318	NA	NA	0.722810345333593	0.812980518656102	0.655986655789584	0.657474436633442	0.675754027969613	0.638456950533741	0.681173914802656	NA	NA	0.634417474677893	0.654498874945726	NA	NA	p.Asp162Arg	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.902	-3.72	1.818	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162S	162	D	S	missense	wt-like	1.0706822902798	0.074865935644582	6	0.0305638902408782	1.01077816618025	1.13058641437936	0.953869881006801	1.10978936743458	1.10172592870547	1.061964358865	NA	NA	1.02668919726121	1.17005500840576	0.716041296145833	0.676453525141365	0.697277137094274	0.748174141438942	0.744859069230269	NA	NA	0.696926896527665	0.734805455197391	NA	NA	p.Asp162Ser	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.902	-3.428	1.526	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162T	162	D	T	missense	wt-like	0.844908567067848	0.117853587955088	6	0.0481135258076971	0.750607789315523	0.939209344820172	0.988766027120245	0.88423801555485	0.718884477337532	0.967423575788834	NA	NA	0.745809328492148	0.764329978113477	0.646033788342292	0.683886361336206	0.64851028017845	0.633622235438812	0.713546795764105	NA	NA	0.639148482220058	0.643557296506134	NA	NA	p.Asp162Thr	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.902	-2.619	0.717	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162V	162	D	V	missense	wt-like	0.905013938062021	0.0622568200018745	6	0.0254162403354817	0.855199022382063	0.95482885374198	0.86716307404081	0.986791123967502	0.872892500712858	0.963991673608824	NA	NA	0.915688409581367	0.823556846460767	0.672388470229718	0.657985081919564	0.670683469221891	0.679703746607259	0.712410136471966	NA	NA	0.674093471237546	0.656877506693429	NA	NA	p.Asp162Val	1	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.902	-2.958	1.056	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162W	162	D	W	missense	wt-like	0.932364229834079	0.101456153957577	6	0.0414193014102191	0.851183890805241	1.01354456886292	0.831027258114507	1.11322478053564	0.866080348962227	0.944911810203297	NA	NA	0.877023277724737	0.961917903464067	0.682830280707841	0.650288197579558	0.698019913840013	0.677665448601103	0.70609081182485	NA	NA	0.666139857411603	0.687995112814579	NA	NA	p.Asp162Trp	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.902	-5.716	3.814	0.006707322	NA	NA	NA	NA	NA	NA	NA
D162X	162	D	X	nonsense	low	-0.189041225582942	0.161305556549941	6	0.0658527177038354	-0.318110180566543	-0.0599722705993419	-0.276713101974746	0.0775891437299591	-0.182045815542093	-0.0884138585810579	NA	NA	-0.326003897977107	-0.338659823152611	0.404917062156974	0.414340863561931	0.474103300190266	0.364050375197822	0.363849348746274	NA	NA	0.4186710627072	0.395493260752017	NA	NA	p.Asp162Ter	0	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D162Y	162	D	Y	missense	wt-like	0.788638640837388	0.0575228595849547	6	0.0234836090881506	0.742611612797595	0.83466566887718	0.827945627849791	0.854598891784973	0.766980624856685	0.75139433622517	NA	NA	0.82757519002421	0.703337174283497	0.645057638570327	0.649631814124026	0.642101952780055	0.6480133243606	0.641997075042467	NA	NA	0.655968134851347	0.629839924819962	NA	NA	p.Asp162Tyr	1	26.5	12.6	2.2	0.469	77.7	96.8	-83.9	-5.2	31.0160427807487	-5.5	0	0	13.94	0	0	0	0	7	13.5833253128135	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.902	-4.613	2.711	0.006707322	NA	NA	NA	NA	NA	NA	NA
R163A	163	R	A	missense	possibly_low	0.62307545184505	0.15162622592664	6	0.0619011475240381	0.501751432096234	0.744399471593865	0.502912333568059	0.577749790688298	0.582156702322135	0.468495572446866	NA	NA	0.865753292736695	0.741385019308245	0.587477576283051	0.580400122280134	0.582243918731758	0.592711233834344	0.548299908947184	NA	NA	0.66382156431095	0.638396941374197	NA	NA	p.Arg163Ala	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-0.974	-3.42	2.446	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163C	163	R	C	missense	low	0.410939184072733	0.202681911052074	6	0.0827445436949579	0.248762858513415	0.573115509632051	0.19733824131677	0.124210546518994	0.466836184408722	0.618520518240318	NA	NA	0.488760806325428	0.569968807626166	0.572238950782772	0.515313216531084	0.484183396186499	0.55820560472678	0.597988751968996	NA	NA	0.586272296838763	0.599845182133333	rs112339338	*33	p.Arg163Cys	1	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-0.974	-3.853	2.879	0.002606616	0.35399361	0.137163325095215	NA	NA	0.0002058	NA	NA
R163D	163	R	D	missense	low	0.049958885652645	0.191727474632904	6	0.0782724137538368	-0.103452226287893	0.203369997593183	-0.0619358704606289	0.293956074973127	0.0658399359285346	-0.106984101570071	NA	NA	-0.153910363499539	0.262787638544447	0.457079862845505	0.460088149667278	0.520884377267906	0.438221511055167	0.357698812354624	NA	NA	0.454071576023733	0.530759683407406	NA	NA	p.Arg163Asp	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-0.974	-3.982	3.008	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163E	163	R	E	missense	low	0.196616109049431	0.205701932228164	6	0.0839774621772615	0.0320233076689235	0.361208910429938	0.0223880362270963	0.249221735424736	0.26846278872498	0.552192069386193	NA	NA	0.0504451721023564	0.0369868524312229	0.497478927617321	0.478049038061122	0.511212286554198	0.498849308552229	0.576020512850081	NA	NA	0.496108546682414	0.47997675303452	NA	NA	p.Arg163Glu	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-0.974	-3.596	2.622	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163F	163	R	F	missense	low	0.0883484128413609	0.374234740559293	6	0.152780693065519	-0.211096243100124	0.387793068782846	0.670725643288692	0.44210951006453	-0.0363759502392371	-0.157297173727216	NA	NA	-0.195801284849681	-0.193270267488922	0.436822993767539	0.616144150815907	0.552916893634924	0.407636984374024	0.341034928017659	NA	NA	0.445454400929971	0.428191586605106	NA	NA	p.Arg163Phe	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-0.974	-4.566	3.592	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163G	163	R	G	missense	low	0.0415992315454331	0.108214728654015	6	0.0441784779760126	-0.0449889941793475	0.128187457270214	0.0164314503019699	0.0266699920684451	0.032362318292671	0.251898181814365	NA	NA	-0.0535461685074471	-0.0242203846974051	0.470464077603083	0.476780292586535	0.463093980305203	0.428204505595521	0.476562014391369	NA	NA	0.474717000223466	0.466211154982699	NA	NA	p.Arg163Gly	1	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-0.974	-3.167	2.193	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163H	163	R	H	missense	possibly_wt-like	0.763139598800744	0.292212821646862	6	0.119295384888953	0.529324940896553	0.996954256704936	0.583212295560347	0.543502954850104	NA	NA	1.26830032654935	0.557666241164179	0.664866469132359	0.961289305548124	0.610001020357874	0.597503915403886	0.574839349753463	NA	NA	0.691430538396499	0.587157874002472	0.622498125311862	0.687853740214655	rs144041067	*16	p.Arg163His	1	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-0.974	-2.991	2.017	0.002606616	NA	NA	1.15	0.24	0.0006609	NA	NA
R163I	163	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg163Ile	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-0.974	-4.194	3.22	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163K	163	R	K	missense	possibly_low	0.667007199954292	0.147594384519636	6	0.0602551551622075	0.548909265953493	0.785105133955092	0.795030582907559	0.896796689316721	0.598141023592733	0.532195577425351	NA	NA	0.540281927394376	0.639597399089015	0.606499368893137	0.642620950041612	0.65122561325579	0.597493982570467	0.569397597275779	NA	NA	0.59687045288234	0.615504755215806	NA	NA	p.Arg163Lys	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-0.974	-3.343	2.369	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163L	163	R	L	missense	possibly_wt-like	0.752914979022476	0.101007180046431	6	0.0412360085785309	0.672093887342371	0.833736070702582	0.703434891951028	0.946852031298805	0.699075286733875	0.729138051255663	NA	NA	0.668237991228588	0.770751621666899	0.631160367843257	0.623111180543862	0.662048167321502	0.627695028413918	0.634625707272596	NA	NA	0.623191664515568	0.645001533628008	NA	NA	p.Arg163Leu	1	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-0.974	-3.183	2.209	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163M	163	R	M	missense	wt-like	0.852594838141772	0.12877602095266	6	0.052572590406662	0.749554454370739	0.955635221912805	0.954240412864362	0.986538426584202	0.939634040216085	0.797198456821309	NA	NA	0.783370467301608	0.654587225063065	0.663898205117447	0.676532447971218	0.670628833073485	0.69967381654655	0.657167577161409	NA	NA	0.646874999074076	0.618875989221875	NA	NA	p.Arg163Met	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-0.974	-4.808	3.834	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163N	163	R	N	missense	low	-0.256585479027243	0.172841260873094	6	0.070562149273059	-0.394884750274178	-0.118286207780308	-0.387387347666035	-0.0387981502408917	-0.237743836495298	-0.0787178421009265	NA	NA	-0.477795313139955	-0.319070384520352	0.389107091865105	0.390767385375068	0.448938997406911	0.347384691694045	0.367060706952539	NA	NA	0.387446798355141	0.399898954439935	NA	NA	p.Arg163Asn	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-0.974	-3.857	2.883	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163P	163	R	P	missense	low	-0.0140497040767066	0.102919183093761	6	0.0420165805539652	-0.0964006887160044	0.0683012805625911	0.075609062585198	-0.0488994991398574	-0.0325521990676868	0.142872864119767	NA	NA	-0.104630074512366	-0.116698378445295	0.446083842228701	0.489385051205812	0.446754966886556	0.408781108092096	0.440452406967891	NA	NA	0.464208781537171	0.445412717570846	ND	*22	p.Arg163Pro	1	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-0.974	-3.434	2.46	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163Q	163	R	Q	missense	possibly_wt-like	0.775752616918695	0.200504462214272	6	0.0818556039293529	0.615318581284388	0.936186652553002	0.890196735853947	1.12724879724535	0.734542345492526	0.654706666719349	NA	NA	0.593082363260323	0.654738792940672	0.628608690783223	0.662891223551015	0.701052071309113	0.638307304504987	0.609973744476936	NA	NA	0.607731770471438	0.61891007706146	NA	NA	p.Arg163Gln	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-0.974	-2.526	1.552	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163R	163	R	R	synonymous	wt-like	1.12401607868951	0.11582011645165	6	0.0472833645427115	1.03134238711792	1.2166897702611	0.990424911144469	1.06952213614909	1.2493246371839	1.27590220021371	NA	NA	1.03754816580171	1.12137442164418	0.711508880389079	0.684239701592697	0.68857088776289	0.792337889431609	0.815716110764127	NA	NA	0.699160641459389	0.723857119318769	NA	NA	p.Arg163=	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163S	163	R	S	missense	low	0.096819709914015	0.218072438969583	6	0.0890277004066172	-0.0776713765093766	0.271310796337407	0.342099832000632	0.199524237626721	0.29809278772139	0.0419743783321307	NA	NA	-0.176142205612342	-0.124630770584441	0.474982737950111	0.546147257268984	0.500467102612748	0.507715048789324	0.407034437743341	NA	NA	0.449498373287474	0.44362871086021	NA	NA	p.Arg163Ser	1	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-0.974	-3.207	2.233	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163T	163	R	T	missense	wt-like	0.872506587809076	0.0689914764350138	2	0.0487843408312701	0.776891036770259	0.968122138847892	0.823722246977805	0.921290928640346	NA	NA	NA	NA	NA	NA	0.65262689763878	0.648732239193665	0.656521556083896	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg163Thr	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-0.974	-3.233	2.259	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163V	163	R	V	missense	low	0.542785926584393	0.203689788193215	6	0.0831560078148265	0.379803146169202	0.705768706999584	0.697534886935681	0.877064199063432	0.500257032043662	0.352355995541404	NA	NA	0.393530686384055	0.435972759538122	0.568957448358048	0.621854486733456	0.646959216620365	0.568205623750433	0.509834031322937	NA	NA	0.566682977929405	0.569709272965662	NA	NA	p.Arg163Val	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-0.974	-3.141	2.167	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163W	163	R	W	missense	wt-like	1.010377214439	0.0516880846109725	6	0.021101572179781	0.969018892949453	1.05173553592854	1.04491896824705	0.945178645870015	1.06666122943786	0.966980792378681	NA	NA	1.0560401609573	0.982483489743072	0.699405703709477	0.69584686871995	0.661686361696793	0.73768225734417	0.713400144183974	NA	NA	0.702964538699004	0.692620343550316	NA	NA	p.Arg163Trp	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-0.974	-5.632	4.658	0.002606616	NA	NA	NA	NA	NA	NA	NA
R163X	163	R	X	nonsense	low	0.0111224037614013	0.216059410347671	6	0.088205884913067	-0.161757953892695	0.184002761415498	0.0679677085513236	-0.170422456408626	0.19698268193998	0.316473675053061	NA	NA	-0.205819319326667	-0.138447867240663	0.460427514296055	0.487757452196571	0.420480273253711	0.477461388189747	0.497949667822094	NA	NA	0.443393640402363	0.440521225410197	NA	NA	p.Arg163Ter	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R163Y	163	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg163Tyr	0	29.2	14.3	4.4	0.863	81.5	48.7	-62.2	-39.9	7.16981132075472	-5	1	0	14.75	0	0	0	0	8	13.7625922244153	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-0.974	-4.411	3.437	0.002606616	NA	NA	NA	NA	NA	NA	NA
K164A	164	K	A	missense	wt-like	1.13380045943239	0.157886531037438	6	0.0644569063833037	1.00746724436624	1.26013367449853	0.912853783335659	0.981894220871001	1.22830191533793	1.31008359588323	NA	NA	1.24620482446575	1.12346441670076	0.733204768626098	0.667717146793164	0.669624701138049	0.786047575652468	0.827037121378106	NA	NA	0.742082374957648	0.724327162294547	NA	NA	p.Lys164Ala	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.512	-2.396	-0.116	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164C	164	K	C	missense	wt-like	1.08799260773463	0.159636768627103	6	0.0651714378871902	0.960258936655046	1.21572627881421	1.23941584873866	1.12234380117317	0.998616309538371	1.07012799702095	NA	NA	1.26310805361701	0.83434363631961	0.727298330720522	0.737274465005276	0.699991553428678	0.717322196435768	0.747562897801393	NA	NA	0.745559454968109	0.659303471668032	NA	NA	p.Lys164Cys	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.512	-4.535	2.023	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164D	164	K	D	missense	wt-like	0.962456457448541	0.139746946824946	6	0.0570514521388287	0.850637665990727	1.07427524890636	0.834322475016023	1.18276603594723	0.85958774860982	0.890882099344665	NA	NA	1.08606015567277	0.921120230100736	0.683507809080927	0.650990074725986	0.713055551729749	0.67572276516751	0.688195962357185	NA	NA	0.709139803945971	0.67881965580467	NA	NA	p.Lys164Asp	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.512	-2.942	0.43	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164E	164	K	E	missense	wt-like	1.09971566438257	0.0803185741745264	6	0.0327899205992454	1.03544860095212	1.16398272781302	0.944786815926275	1.10389557804663	1.09844624045418	1.16802282308897	NA	NA	1.14721418709655	1.13592834168278	0.72442490798347	0.674518843452701	0.696002830461312	0.74719280950916	0.779986043295067	NA	NA	0.72171949853095	0.72713031743599	NA	NA	p.Lys164Glu	1	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.512	-2.19	-0.322	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164F	164	K	F	missense	possibly_wt-like	0.801981088797787	0.270457009551801	6	0.110413611793491	0.585574386279557	1.01838779131602	0.93925371242625	1.20470393915235	0.938588600300793	0.543711296704709	NA	NA	0.669753671421554	0.515875312781062	0.648421873418086	0.673340299213716	0.717798784602092	0.699361005239213	0.573211648095988	NA	NA	0.623503447622455	0.587679475230225	NA	NA	p.Lys164Phe	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.512	-4.196	1.684	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164G	164	K	G	missense	wt-like	1.01207450890018	0.0967397141784463	6	0.0394938229333134	0.934668038339079	1.08948097946127	0.862763801745095	1.00404149699159	0.944065918870639	1.0439086096693	NA	NA	1.1148093213507	1.10285790477374	0.708026777171221	0.65704804233232	0.674413202898941	0.700999901131243	0.738878935175352	NA	NA	0.7150536532112	0.719692727320113	NA	NA	p.Lys164Gly	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.512	-2.884	0.372	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164H	164	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164His	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.512	-3.765	1.253	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164I	164	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Ile	1	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.512	-3.517	1.005	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164K	164	K	K	synonymous	wt-like	0.910836732934942	0.081488410460961	6	0.0332675042633049	0.845633622723331	0.976039843146552	0.900415126285914	1.04875759940924	0.912831526464559	0.817330272232317	NA	NA	0.844489864853792	0.941196008363829	0.674201228068477	0.665067728142921	0.684081350530341	0.691654102315342	0.663835312386449	NA	NA	0.65944756929592	0.683334727994032	NA	NA	p.Lys164=	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164L	164	K	L	missense	wt-like	1.07300019211637	0.193662785251279	6	0.0790625010053049	0.918040537618308	1.22795984661443	0.980911208212145	0.95908671452601	1.0845144500718	0.821559518539262	NA	NA	1.33651360374979	1.2554156575992	0.712618751690078	0.682213294571347	0.664693449832022	0.743024208808808	0.665236055141162	NA	NA	0.760659349120852	0.754003191304479	NA	NA	p.Lys164Leu	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.512	-3.09	0.578	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164M	164	K	M	missense	wt-like	1.07212244671966	0.0861652266478584	6	0.0351768064764195	1.00317717293475	1.14106772050458	1.04457849166326	1.18057660798133	1.17360392140745	1.03520794018804	NA	NA	1.03372248381171	0.965045235266199	0.70547792544793	0.695774347626438	0.712582171634925	0.769681115237245	0.735997239749617	NA	NA	0.698373679260936	0.688698454356893	NA	NA	p.Lys164Met	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.512	-3.949	1.437	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164N	164	K	N	missense	wt-like	1.29261941220852	0.228364752146929	6	0.0932295196661877	1.10989291136682	1.47534591305022	1.2106650497999	1.14770672353957	1.24280631117072	1.02622719784518	NA	NA	1.64202131555557	1.48628987534018	0.761705145800943	0.731150580198975	0.705475315754647	0.790387508494354	0.733022783107532	NA	NA	0.823503835713077	0.805927143945439	NA	NA	p.Lys164Asn	1	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.512	-3.198	0.686	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164P	164	K	P	missense	wt-like	1.16448698911479	0.0993830144470905	6	0.0405729457491701	1.08496547669972	1.24400850152987	1.27994822165632	1.09496963457558	1.13042324843366	1.20497038163807	NA	NA	1.25460386105592	1.02200658732923	0.744858954990252	0.745907810576037	0.694072936428472	0.756760810046044	0.79222321776679	NA	NA	0.743810099404466	0.701509146585006	NA	NA	p.Lys164Pro	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.512	-2.775	0.263	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164Q	164	K	Q	missense	wt-like	1.45142771730625	0.110099870926817	6	0.0449480840861649	1.36333109132329	1.53952434328922	1.40762678997211	1.29531019881794	1.46523777485117	1.60911188810667	NA	NA	1.39908261908634	1.5321970330033	0.794890922299767	0.773103188564134	0.737388924337304	0.85694233955549	0.926076449756383	NA	NA	0.773530113076908	0.816251731522625	NA	NA	p.Lys164Gln	1	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.512	-2.416	-0.096	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164R	164	K	R	missense	possibly_wt-like	0.859262624712654	0.177028780099472	6	0.0722716968385124	0.717612701807573	1.00091254761774	0.963068679499923	0.998373615086553	0.954135427046992	0.87978850612972	NA	NA	0.842817911292847	0.51739160921989	0.67580029901358	0.678412857904543	0.673187740122616	0.704012849049928	0.684521721324203	NA	NA	0.659103639964242	0.588020492539346	NA	NA	p.Lys164Arg	1	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.512	-2.778	0.266	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164S	164	K	S	missense	wt-like	0.838586640848264	0.137248172650726	6	0.0560313318539479	0.728767248408714	0.948406033287813	0.747460549418662	0.931285714359366	0.737800153456219	1.0779226164791	NA	NA	0.76456036505511	0.772490446321126	0.644199131726583	0.632488591426521	0.658682546390546	0.639282089524451	0.750144505950774	NA	NA	0.643005665591653	0.645392597861513	NA	NA	p.Lys164Ser	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.512	-2.811	0.299	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164T	164	K	T	missense	wt-like	1.2050304524421	0.375507330141327	6	0.153300225586846	0.904567531470015	1.50549337341418	0.673551742051847	0.852168351827297	1.19488349913989	1.36877549249128	NA	NA	1.61589703394018	1.52490659520211	0.795330192721086	0.616746106375947	0.641576441434827	0.776048284151215	0.846476104820396	NA	NA	0.818129938419272	0.814612101290956	NA	NA	p.Lys164Thr	1	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.512	-2.947	0.435	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164V	164	K	V	missense	possibly_wt-like	0.748550089542485	0.316772398448225	6	0.129321790132626	0.495084038466292	1.00201614061868	1.14080464675614	1.07036306925878	0.356436322617883	0.831954090477498	NA	NA	0.519135126295226	0.572607281849382	0.63455867825214	0.716270400289087	0.688752707398615	0.525172309755444	0.668678777620322	NA	NA	0.592520448588541	0.600438578883958	NA	NA	p.Lys164Val	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.512	-2.859	0.347	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164W	164	K	W	missense	wt-like	1.07025299302941	0.208989748916702	6	0.0853197077197157	0.903029438727279	1.23747654733153	0.722767929545855	1.03935365521981	1.03073737720796	1.06754874808153	NA	NA	1.22284824460486	1.33826200351642	0.732105554876236	0.627229093769119	0.682048107116331	0.726933301793255	0.746708640564457	NA	NA	0.737277807959218	0.772635456890361	NA	NA	p.Lys164Trp	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.512	-4.634	2.122	0.00884798	NA	NA	NA	NA	NA	NA	NA
K164X	164	K	X	nonsense	low	-0.133626011837906	0.160618817817958	6	0.0655723577905082	-0.262145471488677	-0.00510655218713599	-0.342499245014106	-0.317303940872045	-0.0783220545017454	-0.0194501442065018	NA	NA	0.0508868684265001	-0.0950675548595408	0.39770728834223	0.40032849602105	0.388722767582758	0.39508608066341	0.386690398010683	NA	NA	0.496199405857642	0.450277521750547	NA	NA	p.Lys164Ter	1	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K164Y	164	K	Y	missense	wt-like	0.980567039304889	0.177856501779617	6	0.0726096127994116	0.838254813286643	1.12287926532313	1.10208198301884	0.965954344092358	1.16183448249799	0.945541416698652	NA	NA	0.657704883178902	1.0502851263426	0.70708418585967	0.708022520547537	0.666178312173222	0.76615952253924	0.706299339934277	NA	NA	0.621024950740356	0.707869031785063	NA	NA	p.Lys164Tyr	0	30	17.2	2.1	0.954	113.6	46.8	-65.5	-46.5	48.2608695652174	-3.6	1	0	16.61	1	4	1	4	6	16.8427621144701	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.512	-4.765	2.253	0.00884798	NA	NA	NA	NA	NA	NA	NA
C165A	165	C	A	missense	possibly_wt-like	0.810959422408006	0.174975262143115	6	0.0714333516433929	0.67095262589197	0.950966218924041	0.921543034288947	1.08895204683545	0.772318396187173	0.687028964452207	NA	NA	0.80086991251533	0.595044180168929	0.650042594689515	0.669567946557175	0.692771863134716	0.649610465624994	0.620679014654893	NA	NA	0.650474723754035	0.605484670462106	NA	NA	p.Cys165Ala	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-3.365	-2.425	-0.94	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165C	165	C	C	synonymous	wt-like	1.06491616476074	0.27519873796406	4	0.13759936898203	0.795226357260527	1.33460597226096	1.43968740569039	1.08588442412373	NA	NA	NA	NA	0.930311765148664	0.803781064080187	0.684605088341319	0.77993206027292	0.692108606999884	NA	NA	NA	NA	0.677101569682755	0.652429904021228	NA	NA	p.Cys165=	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	0	2.5	2.5	0	148	148	0	5.5	5.5	0	121	121	0	5.07	5.07	0	NA	NA	NA	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165D	165	C	D	missense	wt-like	1.01664020457764	0.235585758177324	6	0.0961774830335254	0.828135801708218	1.20514460744706	1.1853290015935	1.27949685781723	0.700392117049181	0.862646973791257	NA	NA	0.869437449937078	1.20253882727759	0.702299206265378	0.725754033098027	0.733969893896937	0.628089043800595	0.678844379432729	NA	NA	0.664579414142022	0.742111114050086	NA	NA	p.Cys165Asp	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-3.365	-2.668	-0.697	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165E	165	C	E	missense	wt-like	1.01035149949615	0.180392220455829	6	0.0736448156140726	0.866010313244476	1.15469268574783	0.893075639396783	0.95617484274378	0.993503592573851	1.32008324178857	NA	NA	1.09528549144885	0.803986189025066	0.687550685604791	0.66350442646417	0.664063868881264	0.715792394814151	0.830349042825812	NA	NA	0.711037502328319	0.652476036924363	NA	NA	p.Cys165Glu	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-3.365	-2.782	-0.583	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165F	165	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys165Phe	1	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-3.365	-4.774	1.409	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165G	165	C	G	missense	possibly_low	0.642423570369184	0.278214132608394	6	0.113580444020263	0.4198099907414	0.865037149996967	0.829341612745225	0.886134338152644	0.404440428979975	0.943692032871437	NA	NA	0.287512860985687	0.503420148480136	0.616899288910937	0.64992915718949	0.648920287442969	0.539535858582151	0.705686816848923	NA	NA	0.544874573266219	0.584878290378904	NA	NA	p.Cys165Gly	1	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-3.365	-3.294	-0.071	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165H	165	C	H	missense	possibly_low	0.633212002340196	0.156478889769306	6	0.0638822392420024	0.5080051141741	0.758418890506292	0.931042111890598	0.667438709210205	0.606922379176218	0.525131460806244	NA	NA	0.55227704352071	0.516460309437203	0.599729702522518	0.671591238401083	0.601635718515007	0.600121495907277	0.567057934495578	NA	NA	0.599337909137758	0.587811041842408	NA	NA	p.Cys165His	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-3.365	-3.47	0.105	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165I	165	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys165Ile	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-3.365	-3.732	0.367	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165K	165	C	K	missense	possibly_low	0.588640318315563	0.226088804892398	6	0.0923003680903392	0.407734921098708	0.769545715532418	0.907868970411402	0.798453107669157	0.521847545890062	0.58380430776671	NA	NA	0.376585837026072	0.343282141129978	0.58057821901774	0.666655387772341	0.629962573443225	0.574665829414658	0.586490608620821	NA	NA	0.563197336431223	0.548863015953606	NA	NA	p.Cys165Lys	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-3.365	-2.324	-1.041	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165L	165	C	L	missense	wt-like	0.97737152870103	0.199061853703381	6	0.0812666614709729	0.818091799074114	1.13665125832795	1.22611242006492	1.02719747585792	1.1868104693641	0.779417900101461	NA	NA	0.785897031153832	0.858793875663933	0.672111082341208	0.734440851062919	0.67941979806545	0.773632712523045	0.651278587920184	NA	NA	0.647394726079319	0.664802366616965	NA	NA	p.Cys165Leu	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-3.365	-3.111	-0.254	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165M	165	C	M	missense	possibly_wt-like	0.728248271713618	0.267397371034179	6	0.109164519599235	0.514289744909501	0.942206798517735	1.06735809128297	0.991034086163102	0.720438514809832	0.635507675489437	NA	NA	0.337719347267367	0.617431915269003	0.622303465962618	0.700626374323222	0.671600847586364	0.634087226765669	0.603614964233058	NA	NA	0.555202302263049	0.610519705159566	NA	NA	p.Cys165Met	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-3.365	-3.838	0.473	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165N	165	C	N	missense	possibly_wt-like	0.996563018263773	0.344227650864228	5	0.153943285413496	0.694839723191551	1.29828631333599	1.43803434738087	1.21019878409413	0.548502907000573	0.818068073280748	NA	NA	0.968010979562543	NA	0.684856489389255	0.779579960886493	0.718986834750394	0.582641513367951	0.66407967495084	NA	NA	0.684856489389255	NA	NA	NA	p.Cys165Asn	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-3.365	-3.328	-0.037	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165P	165	C	P	missense	wt-like	1.31730042947875	0.231753890162418	4	0.115876945081209	1.09018579048106	1.54441506847645	1.65390551570686	1.17550336889995	NA	NA	NA	NA	1.28602176324727	1.15377107006093	0.740708047360064	0.825560254187066	0.711485277635755	NA	NA	NA	NA	0.750272921312789	0.731143173407338	NA	NA	p.Cys165Pro	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-3.365	-3.544	0.179	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165Q	165	C	Q	missense	wt-like	1.38792784888786	0.364493285908589	6	0.148803760857738	1.09627783684259	1.67957786093314	0.81741070470546	1.16706958570275	1.36724198614588	1.49467320458989	NA	NA	1.61923744866665	1.86193416351654	0.8232188040141	0.647387888453768	0.709661794446631	0.827620529349031	0.888173914609217	NA	NA	0.818817078679168	0.890410099296474	NA	NA	p.Cys165Gln	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-3.365	-2.426	-0.939	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165R	165	C	R	missense	wt-like	1.15606377308539	0.181580067262556	6	0.0741297520422519	1.01077212889969	1.30135541727109	0.890933138541976	1.02571529551434	1.33568364424345	1.36889831480732	NA	NA	1.1559620456695	1.15919019973576	0.727940460553298	0.663048076417684	0.679099333230561	0.818177799983622	0.846516784047102	NA	NA	0.723518977429695	0.732361943676901	NA	NA	p.Cys165Arg	1	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-3.365	-1.938	-1.427	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165S	165	C	S	missense	wt-like	1.09206409765583	0.248544779510338	6	0.101467981338813	0.893190508647774	1.29093768666389	0.982060664384915	0.920390428035365	1.56270654621139	1.13853238334264	NA	NA	0.885123351349949	1.06357121261073	0.696657609768241	0.682458127322149	0.656326857254606	0.886106458265492	0.770218695448681	NA	NA	0.667806083659467	0.710857092214332	NA	NA	p.Cys165Ser	1	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-3.365	-2.8	-0.565	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165T	165	C	T	missense	wt-like	1.28631851612919	0.0794388190748785	6	0.0324307620837872	1.22275539045378	1.3498816418046	1.26259330305464	1.18903847503283	1.25860873071027	1.25125529587929	NA	NA	1.41455218987475	1.34186310222338	0.775078815798308	0.742211234262948	0.714411726883882	0.795115829503484	0.807552960602869	NA	NA	0.77671228228715	0.773445349309466	NA	NA	p.Cys165Thr	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-3.365	-2.953	-0.412	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165V	165	C	V	missense	wt-like	1.32316121733989	0.255218810479366	6	0.104192643072422	1.11894738946391	1.52737504521587	1.08953048185338	0.982762338646823	1.51298646324919	1.25917233189292	NA	NA	1.63287820144183	1.4616374869552	0.805278949484056	0.705349066239462	0.669812398418543	0.871229463495326	0.810175113589484	NA	NA	0.8216230507439	0.800382785378628	NA	NA	p.Cys165Val	0	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-3.365	-3.68	0.315	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165W	165	C	W	missense	wt-like	1.1465341954732	0.148915393739294	6	0.0607944549178199	1.02737925337453	1.26568913757187	0.963805676117348	1.02293432401893	1.36989354936239	1.19724142433671	NA	NA	1.09472653793791	1.23060366106592	0.72967272969204	0.678569837277442	0.678498054462452	0.828413916844678	0.789663357178016	NA	NA	0.710922522754755	0.748422936629325	NA	NA	p.Cys165Trp	1	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-3.365	-4.514	1.149	0.007582777	NA	NA	NA	NA	NA	NA	NA
C165X	165	C	X	nonsense	low	0.074482763531003	0.338549201206783	6	0.138212132630576	-0.196408038651398	0.345373565713404	-0.201225282302703	-0.277101322341937	0.292416796356731	-0.192293490344365	NA	NA	0.29807752308273	0.527022356735562	0.468218191653756	0.430419676291104	0.397415046875966	0.506016707016408	0.329444012430026	NA	NA	0.54704777786909	0.590186461883146	NA	NA	p.Cys165Ter	1	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C165Y	165	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys165Tyr	1	26.3	18	1.7	0.924	113.9	50	-59	-43.8	44.5945945945946	-3.1	1	0	14.82	0	0	0	0	7	15.6282128103193	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-3.365	-4.714	1.349	0.007582777	NA	NA	NA	NA	NA	NA	NA
Y166A	166	Y	A	missense	low	0.0144885972266422	0.152002657682596	6	0.0620548251448836	-0.10713662512426	0.136113819577545	-0.0561492841247452	-0.0110060256771205	0.0701509873420612	0.277937846485141	NA	NA	-0.0178786040996074	-0.176123336565876	0.458134333638532	0.46132068543848	0.454947981838584	0.43951144231658	0.485186452169525	NA	NA	0.482053999214283	0.432047956700899	NA	NA	p.Tyr166Ala	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-0.705	-3.572	2.867	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166C	166	Y	C	missense	low	0.172790296204319	0.287101084008267	6	0.117208526736697	-0.0569341948806072	0.402514787289245	-0.0867484462503956	0.218103565891875	0.0943825388515002	0.0215787624862857	NA	NA	0.0666808813313132	0.722744474915335	0.477125708002354	0.454803101547126	0.504484172054132	0.44676188607294	0.40027933079271	NA	NA	0.499448314457582	0.634204655402513	NA	NA	p.Tyr166Cys	1	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-0.705	-5.179	4.474	0.001789735	NA	NA	NA	NA	4.06e-06	NA	NA
Y166D	166	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr166Asp	1	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-0.705	-4.159	3.454	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166E	166	Y	E	missense	low	-0.220031064208467	0.235924617533046	6	0.0963158217862066	-0.408806606050811	-0.0312555223661242	-0.193917300265313	-0.0605177861288867	-0.291194023333308	0.115530548176413	NA	NA	-0.573978751157313	-0.316109072542396	0.41598074196112	0.43197626747519	0.44424295649744	0.331391593881675	0.431396526043711	NA	NA	0.367661377080019	0.40056495787853	NA	NA	p.Tyr166Glu	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-0.705	-3.918	3.213	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166F	166	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr166Phe	1	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-0.705	-2.602	1.897	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166G	166	Y	G	missense	low	0.113867386772152	0.0699296362799097	6	0.0285486544640329	0.057913052215569	0.169821721328735	0.0146170893502699	0.0443344255226403	0.12318592831246	0.193583891795495	NA	NA	0.162222968404549	0.145260017247499	0.471653537328151	0.47639383593575	0.466913238720552	0.455380292335448	0.457248095713702	NA	NA	0.519101806589016	0.504327547753896	NA	NA	p.Tyr166Gly	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-0.705	-3.844	3.139	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166H	166	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr166His	1	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-0.705	-3.351	2.646	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166I	166	Y	I	missense	low	0.23855868507168	0.316610163931905	6	0.129255558168684	-0.0147775537405617	0.491894923883922	0.755977761295689	0.299875831552545	0.00270628159607457	-0.165761332498926	NA	NA	0.203172886607481	0.335380681877218	0.52484485543682	0.634302747078921	0.522164298313287	0.419330974487887	0.338231565854821	NA	NA	0.527525412560353	0.547085966094816	NA	NA	p.Tyr166Ile	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-0.705	-3.887	3.182	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166K	166	Y	K	missense	low	-0.192732616632828	0.130371759563936	6	0.0532240479667426	-0.297049833759076	-0.0884153995065799	-0.129466918632472	-0.100422827881132	-0.163227813066168	-0.0583135399709675	NA	NA	-0.387705789881379	-0.317258810364849	0.403142525292531	0.445704119479664	0.435615016805953	0.369681003864154	0.373818690834106	NA	NA	0.405978670441312	0.40030638014375	NA	NA	p.Tyr166Lys	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-0.705	-3.244	2.539	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166L	166	Y	L	missense	low	0.174515553802308	0.19130963763965	6	0.078101832515648	0.021438774945059	0.327592332659558	0.0547676354455438	0.158507471367169	0.164893562474212	0.550557144860023	NA	NA	0.0713975939274592	0.0469699147394431	0.488272323930661	0.484945852863046	0.491598794998277	0.46785984221416	0.575479019515731	NA	NA	0.50041856617318	0.48222195849564	NA	NA	p.Tyr166Leu	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-0.705	-3.454	2.749	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166M	166	Y	M	missense	possibly_low	0.407626974885627	0.479609448300088	6	0.195799737358827	0.0238665414799237	0.791387408291331	-0.322142226115231	0.0292736546390503	0.706594214758294	0.811071205247496	NA	NA	0.875022106912705	0.345942893871449	0.589703113830409	0.404664516004423	0.463656922796922	0.629944804484919	0.661762285162697	NA	NA	0.665728206420791	0.549461423175899	NA	NA	p.Tyr166Met	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-0.705	-4.781	4.076	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166N	166	Y	N	missense	low	-0.208858794246798	0.107952211499172	6	0.0440713057963305	-0.295236966359257	-0.122480622134339	-0.175082026680365	-0.237222800441382	-0.35315841312513	-0.0833343731769398	NA	NA	-0.103043890239923	-0.301311261817046	0.404965130017446	0.435988157578664	0.406037252663392	0.31285091880737	0.365531693982541	NA	NA	0.464535067690974	0.403893007371501	NA	NA	p.Tyr166Asn	1	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-0.705	-4.138	3.433	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166P	166	Y	P	missense	low	-0.058901470474381	0.148895183524586	6	0.0607862041322156	-0.178040241330423	0.0602373003816613	-0.161528406972091	0.053995279142408	0.09537467678339	0.0720377245648869	NA	NA	-0.168115011928701	-0.245173084436179	0.442966905265382	0.438875061903608	0.46900202897711	0.447058748627157	0.416991534436623	NA	NA	0.451149607761534	0.416518566397517	NA	NA	p.Tyr166Pro	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-0.705	-4.382	3.677	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166Q	166	Y	Q	missense	low	0.175316813824988	0.148906806138284	6	0.0607909490443882	0.056168743111978	0.294464884537999	0.0265149506084474	0.0280932697013524	0.388685658840371	0.163496055269496	NA	NA	0.13057601543301	0.314534933097253	0.495759966760277	0.478928065747646	0.463401709680785	0.534821794988365	0.447282887740459	NA	NA	0.512591867772908	0.542397726398729	NA	NA	p.Tyr166Gln	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-0.705	-4.199	3.494	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166R	166	Y	R	missense	low	-0.0289254194746087	0.0879682885242205	6	0.0359129034050449	-0.0993134167287625	0.0414625777795451	-0.133144369853198	-0.126044900217623	0.0325029222631569	0.0640714343016233	NA	NA	-0.0548450811634833	0.0439074778218716	0.437498025049909	0.444920826893448	0.43007522320637	0.428246576412964	0.41435306825179	NA	NA	0.474449807298894	0.481533211908733	NA	NA	p.Tyr166Arg	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-0.705	-4.181	3.476	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166S	166	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr166Ser	1	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-0.705	-3.215	2.51	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166T	166	Y	T	missense	low	-0.0922434536315093	0.204475240485409	6	0.0834766673703554	-0.255854715226836	0.0713678079638171	-0.27228409089324	-0.191552368279054	-0.279238447985066	-0.110100869649475	NA	NA	0.0654124480035331	0.234302607014247	0.415597987545797	0.415284237473966	0.415911737617628	0.334968881394758	0.35666652669697	NA	NA	0.499187391285497	0.524353357735261	NA	NA	p.Tyr166Thr	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-0.705	-3.916	3.211	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166V	166	Y	V	missense	low	0.170218813017811	0.143158904021533	6	0.0584443778314709	0.0556699373692766	0.284767688666345	0.403435351374932	0.0883865943761945	0.0744532249543605	0.281110034193931	NA	NA	0.0319402042006635	0.141987469006784	0.489269536953071	0.559211647444121	0.47643783610119	0.440798736356432	0.486237093023045	NA	NA	0.492301980883097	0.503591546820017	NA	NA	p.Tyr166Val	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-0.705	-3.642	2.937	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166W	166	Y	W	missense	low	0.0793733461514754	0.351752442215209	6	0.143602333200848	-0.202082055018106	0.360828747321057	0.533253316850066	0.514486205211992	-0.182121440098029	-0.0385097226494414	NA	NA	-0.250230607467604	-0.100637674938132	0.441641403293231	0.586862714395389	0.568565586967423	0.364027747196094	0.380377791821729	NA	NA	0.43425801307034	0.449024793516121	NA	NA	p.Tyr166Trp	0	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-0.705	-4.595	3.89	0.001789735	NA	NA	NA	NA	NA	NA	NA
Y166X	166	Y	X	nonsense	low	-0.0983095600788908	0.0377869757904367	2	0.0267194268219497	-0.150678674337466	-0.0459404458203159	-0.0715901332569411	-0.12502898690084	NA	NA	NA	NA	NA	NA	0.444163339595057	0.458031803567807	0.430294875622308	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr166Ter	1	25.8	17.7	5.5	0.92	110.5	49.3	-57.3	-46.8	0	-6.1	1	0	14.1	0	0	0	0	7	12.4518906636371	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A167A	167	A	A	synonymous	wt-like	1.24832007430455	0.295689123334924	6	0.120714579110241	1.01172384683957	1.48491630176953	0.9191094855713	0.84459916541956	1.34627286877368	1.35902119418837	NA	NA	1.45341886136686	1.56749887050754	0.803026804335736	0.669049603673934	0.639939894247506	0.821346254832665	0.843245443448732	NA	NA	0.784707353838807	0.824191166928814	NA	NA	p.Ala167=	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167C	167	A	C	missense	wt-like	1.1215169616602	0.202449762139075	5	0.0905382860343272	0.944065181810931	1.29896874150946	1.13773331586294	0.966762267410882	1.0300500767381	NA	NA	NA	1.46555477496642	1.00748437332264	0.715616210587019	0.715616210587019	0.666352994703586	0.72672765118114	NA	NA	NA	0.787203772848933	0.698243079201223	NA	NA	p.Ala167Cys	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.572	-3.481	1.909	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167D	167	A	D	missense	low	-0.00766696038401899	0.321493695632507	6	0.131249251636881	-0.26491076659014	0.249576845822102	-0.416005903373618	-0.360860526377331	0.309977700730422	0.316927029572378	NA	NA	0.129212387018572	-0.0252524498745368	0.482039431297104	0.38467166821433	0.379305321154812	0.511271193070372	0.498099820594518	NA	NA	0.512311362488438	0.46597904199969	NA	NA	p.Ala167Asp	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.572	-4.262	2.69	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167E	167	A	E	missense	low	-0.122866373151491	0.221473046270755	6	0.0904159925238596	-0.300078462124699	0.0543457158217162	0.245031366337877	0.0243203123870707	-0.192509952944587	-0.294401512337765	NA	NA	-0.350517031871369	-0.169121420480175	0.423625642323894	0.525471793491115	0.462585951903402	0.360919348294074	0.29562544013017	NA	NA	0.413628586675267	0.43362269797252	NA	NA	p.Ala167Glu	1	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.572	-4.105	2.533	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167F	167	A	F	missense	possibly_low	0.685573798227375	0.338210926914311	6	0.138074032728966	0.414953666878397	0.956193929576353	1.08874274002074	1.12199556032399	0.648311434413473	0.461007303815868	NA	NA	0.406718742957327	0.38666700783285	0.590950775140197	0.705181278198146	0.699916259658446	0.612505722192156	0.545819765378107	NA	NA	0.569395828088237	0.558620336567645	NA	NA	p.Ala167Phe	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.572	-3.847	2.275	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167G	167	A	G	missense	wt-like	0.8521463984437	0.0854970460993967	6	0.0349040229097888	0.783735770624953	0.920557026262447	0.915570992439208	0.94011829354215	0.842559455840336	0.913402234935303	NA	NA	0.737865586458087	0.763361827447119	0.664444081477532	0.668295908989659	0.660592253965405	0.670627644496269	0.695654718474542	NA	NA	0.637514414173785	0.643339557991019	rs74423290	*23	p.Ala167Gly	1	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.572	-3.135	1.563	0.006808434	1.047923323	0.00333333351121711	0.9	0.62	1.44e-05	NA	NA
A167H	167	A	H	missense	low	0.247620607028665	0.219479773372554	4	0.109739886686277	0.0325343814560554	0.462706832601275	0.509868199781131	0.170429971794179	NA	NA	NA	NA	0.317355617576005	-0.00717136103665479	0.522594979822302	0.581881713226793	0.494176579913141	NA	NA	NA	NA	0.551013379731463	0.470045505590564	NA	NA	p.Ala167His	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.572	-5.264	3.692	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167I	167	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala167Ile	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.572	-2.653	1.081	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167K	167	A	K	missense	possibly_low	0.597454066349485	0.293581255309325	6	0.119854045592267	0.362544453587221	0.832363679111749	0.711882250433499	0.946732730580687	0.336031844362978	0.193642473354311	NA	NA	0.846791492237495	0.549643607127941	0.610092236011984	0.624910457509152	0.662022373102129	0.519066983734226	0.457267498152841	NA	NA	0.659921025728167	0.595274014514817	NA	NA	p.Ala167Lys	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.572	-4.069	2.497	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167L	167	A	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala167Leu	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.572	-2.799	1.227	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167M	167	A	M	missense	possibly_wt-like	0.77872414051018	0.163574852206425	6	0.066779153776152	0.647839404190861	0.9096088768295	1.01631148471379	0.888705280423168	0.71151859942927	0.636276338242466	NA	NA	0.834108457597951	0.585424682654436	0.640447204839738	0.689753509918721	0.649476155420707	0.631418254258768	0.603869548313525	NA	NA	0.657312061143795	0.603321231260191	NA	NA	p.Ala167Met	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.572	-3.283	1.711	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167N	167	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala167Asn	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.572	-4.355	2.783	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167P	167	A	P	missense	low	-0.155972590850893	0.148894271634725	6	0.0607858318547387	-0.275110632056489	-0.036834549645298	0.0384016999426738	0.00192450504919879	-0.283582394929285	-0.311348861163341	NA	NA	-0.139096376239205	-0.242134117765401	0.437160461433396	0.48145992873341	0.457743714768229	0.333669107297033	0.290012412570145	NA	NA	0.457118888375545	0.417202034491247	NA	NA	p.Ala167Pro	1	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.572	-3.765	2.193	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167Q	167	A	Q	missense	possibly_low	0.680948912125028	0.237710740392704	6	0.0970450033902205	0.490744200600629	0.871153623649428	1.05561208868006	0.846603072978679	0.483506408016786	0.683529535148004	NA	NA	0.597826556068662	0.418615811857979	0.614113832561926	0.698124490218091	0.640373162646891	0.563193585732831	0.619519990117721	NA	NA	0.60870767500613	0.565805669790939	NA	NA	p.Ala167Gln	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.572	-4.511	2.939	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167R	167	A	R	missense	wt-like	0.975559301590714	0.136149012102891	6	0.055582601439349	0.866619404602546	1.08449919857888	0.916306916829866	0.787046198090477	1.07036740058598	1.15360461627078	NA	NA	1.04248646721462	0.883544210552566	0.685272614308087	0.668452659979575	0.627496265338045	0.738791199355184	0.775210677362047	NA	NA	0.700176475119029	0.670368753497146	NA	NA	p.Ala167Arg	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.572	-3.302	1.73	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167S	167	A	S	missense	wt-like	0.894279539310465	0.116549516932949	6	0.0475811410422655	0.801022216524304	0.987536862096626	0.816710549694086	0.703322968984363	0.999229793233184	0.946865712922076	NA	NA	1.00220708357127	0.897341127457813	0.682681251000261	0.647238756297637	0.60939431782001	0.717505759961321	0.706737951971843	NA	NA	0.691890801509169	0.673471700491353	NA	NA	p.Ala167Ser	1	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.572	-2.527	0.955	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167T	167	A	T	missense	possibly_wt-like	0.799480718781232	0.318133561823209	2	0.224954398888221	0.358578198796463	1.240383238766	NA	0.574526319893011	1.02443511766945	NA	NA	NA	NA	NA	0.653297268796924	NA	0.581546966406994	0.725047571186854	NA	NA	NA	NA	NA	NA	NA	p.Ala167Thr	1	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.572	-2.297	0.725	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167V	167	A	V	missense	wt-like	1.00107115212326	0.122515223896683	6	0.0500166307116184	0.903040357300451	1.09910194694608	0.769121164714867	1.00935189105134	1.07971561174705	0.981004056363177	NA	NA	1.10558557857848	1.06164861028467	0.711790489314382	0.637102275838913	0.675561372595643	0.741588324385316	0.718044703521048	NA	NA	0.71315628251783	0.710424696110935	NA	NA	p.Ala167Val	1	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.572	-1.85	0.278	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167W	167	A	W	missense	possibly_low	0.682199375552363	0.160232448715778	6	0.0654146232650548	0.5539890698906	0.810409681214126	0.90084611119008	0.74667103179319	0.592181692510939	0.716762557351804	NA	NA	0.711887425875232	0.424847434592933	0.624646787477009	0.665159527397335	0.618766679186762	0.595710861303253	0.630526895767255	NA	NA	0.632170574717851	0.56720717095002	NA	NA	p.Ala167Trp	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.572	-3.991	2.419	0.006808434	NA	NA	NA	NA	NA	NA	NA
A167X	167	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala167Ter	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A167Y	167	A	Y	missense	possibly_low	0.592439477646494	0.498882413831553	6	0.203667892589217	0.193257743364457	0.991621211928531	1.01312605691811	1.33463602505073	0.188813918381892	0.057645361931955	NA	NA	0.334476591222238	0.625938912374035	0.58348409613268	0.68907501771678	0.745891630816375	0.475017171577622	0.412224728197844	NA	NA	0.554535250889467	0.612432941375894	NA	NA	p.Ala167Tyr	0	28.8	20	6.1	0.922	111.5	48.4	-60.3	-47.3	0	-5.5	1	0	16.65	0	0	0	0	8	15.056951858892	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.572	-4.583	3.011	0.006808434	NA	NA	NA	NA	NA	NA	NA
D168A	168	D	A	missense	wt-like	0.967473719474683	0.104015067173121	6	0.0424639733559105	0.88424586105663	1.05070157789274	0.780388816113659	1.00936832086471	1.03321461758921	1.07879104085065	NA	NA	0.959239062539493	0.943840458890375	0.683490765184674	0.639502271726009	0.675564924914667	0.727674529281236	0.750432131465625	NA	NA	0.683052061545242	0.683929468824106	NA	NA	p.Asp168Ala	1	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.418	-2.237	-0.181	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168C	168	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp168Cys	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.418	-4.499	2.081	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168E	168	D	E	missense	wt-like	1.20997568451468	0.0958377738878313	6	0.0391256073515694	1.13329090323235	1.28666046579701	1.36871768393668	1.21092721080084	1.27340484220257	1.12722041576042	NA	NA	1.13899553576112	1.14058841862644	0.746496986233699	0.764815596842436	0.719144329177644	0.799543048047289	0.766472127979599	NA	NA	0.720028880246381	0.728178375624962	NA	NA	p.Asp168Glu	1	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.418	-2.342	-0.076	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168F	168	D	F	missense	possibly_wt-like	0.792657052936331	0.1862144578582	6	0.0760217340802653	0.64365719209673	0.941656913775932	0.966708139735453	1.04296225773412	0.728745723057622	0.543096007987182	NA	NA	0.674287952274806	0.800142236828803	0.644092197251388	0.679188058457647	0.682828329451578	0.636572868106032	0.573007862090023	NA	NA	0.624436172202805	0.651611526396744	NA	NA	p.Asp168Phe	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.418	-3.471	1.053	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168G	168	D	G	missense	wt-like	1.0550926586599	0.0318074928267057	6	0.0129853545704442	1.02964183137535	1.08054348594446	1.01009634519904	1.0343503020927	1.06017845901603	1.09531676135004	NA	NA	1.08468690742237	1.04592717687924	0.707873121162587	0.688429692847602	0.680966323283003	0.735742515173285	0.755905514091252	NA	NA	0.708857319812428	0.706888922512745	NA	NA	p.Asp168Gly	1	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.418	-2.936	0.518	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168H	168	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp168His	1	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.418	-3.297	0.879	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168I	168	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp168Ile	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.418	-3.817	1.399	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168K	168	D	K	missense	wt-like	1.03918850680542	0.15679726464214	6	0.0640122152395635	0.913726870365252	1.16465014324559	0.820454325084687	0.924452414371663	1.13822052633414	1.20990025196898	NA	NA	0.968734795681803	1.17336872739125	0.710278048765263	0.648036175850449	0.657205106508293	0.759093872576034	0.793856009911424	NA	NA	0.685005382037932	0.735550715492593	NA	NA	p.Asp168Lys	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.418	-2.564	0.146	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168L	168	D	L	missense	wt-like	0.883788008345561	0.148753731108809	6	0.0607284564252923	0.764762420915278	1.00281359577584	0.620549595361696	0.828920771576396	0.882782747632195	0.939358629546263	NA	NA	1.03164604174847	0.999470264208345	0.689551875545277	0.605456714331277	0.636550040970868	0.682663056868397	0.704251576886422	NA	NA	0.697946544591793	0.696440694222157	NA	NA	p.Asp168Leu	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.418	-3.423	1.005	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168M	168	D	M	missense	possibly_wt-like	0.99691991190915	0.462388972783148	6	0.188769507668062	0.626938475500391	1.36690134831791	0.360505838185233	0.486082995768671	1.39874815855307	1.17176258989633	NA	NA	1.12692975363846	1.43749013541313	0.749385778090463	0.550067713944245	0.562424478792593	0.837047648818766	0.781224668543996	NA	NA	0.71754688763693	0.794952010343878	NA	NA	p.Asp168Met	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.418	-4.371	1.953	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168N	168	D	N	missense	wt-like	1.28989171206495	0.345025346599554	6	0.14085600791597	1.01381900954356	1.56596441458634	0.826276413147148	0.983468707116237	1.46243213028906	1.31947306765208	NA	NA	1.79118428243108	1.35651567175412	0.803443842316047	0.64927627344574	0.669965123595274	0.856102848609566	0.83014695078889	NA	NA	0.854187414914587	0.776740733843204	NA	NA	p.Asp168Asn	1	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.418	-2.842	0.424	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168P	168	D	P	missense	possibly_wt-like	0.769773051678954	0.122137907308015	6	0.0498625918593309	0.672044167458845	0.867501935899062	0.761357050010364	0.848002813985269	0.727502625049977	0.713656843231128	NA	NA	0.96161735949074	0.606501618306244	0.635824721744925	0.635448528957841	0.640675803126847	0.636200914532008	0.629498271223539	NA	NA	0.683541289296586	0.608061465225288	NA	NA	p.Asp168Pro	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.418	-3.607	1.189	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168Q	168	D	Q	missense	wt-like	1.02103278927138	0.125784274890375	6	0.0513512151912323	0.920386256934194	1.12167932160856	0.913934394653606	0.962133492745062	1.17644454356184	1.18189476460148	NA	NA	0.908156239069055	0.98363330099721	0.682711501670886	0.667947315674578	0.66535219914221	0.770531072003549	0.784580484043419	NA	NA	0.672544065541783	0.69287893779999	NA	NA	p.Asp168Gln	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.418	-2.448	0.03	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168R	168	D	R	missense	wt-like	0.896473602865413	0.0954254648714069	6	0.0389572829004713	0.820118731444951	0.972828474285875	1.01360378717522	0.960270397338372	0.897858210422073	0.74207955973204	NA	NA	0.924416223635789	0.840613438888983	0.670419101432296	0.689176773673866	0.664949375987477	0.68717386151153	0.638911984996258	NA	NA	0.675888826877116	0.660713559528278	NA	NA	p.Asp168Arg	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.418	-2.539	0.121	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168S	168	D	S	missense	wt-like	1.47008076914894	0.241413361803407	6	0.0985565922513748	1.27691339789724	1.66324814040063	1.42473338432643	1.12439083642665	1.27638079115288	1.56551519463531	NA	NA	1.67285093733182	1.75661347102052	0.815139570988033	0.776746872118013	0.700434146543178	0.800433496621232	0.911637056049479	NA	NA	0.829845645354834	0.86672331996362	NA	NA	p.Asp168Ser	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.418	-2.694	0.276	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168T	168	D	T	missense	wt-like	1.01952004561932	0.128644364349468	6	0.0525188418234807	0.916585007135545	1.1224550841031	0.801377329089764	0.986768149982883	0.982331057004567	1.17344164251016	NA	NA	1.08401933841862	1.08918275670994	0.710584701015835	0.643972799171003	0.670678501976023	0.712449404550837	0.781780777271865	NA	NA	0.708719997480834	0.716617166318238	NA	NA	p.Asp168Thr	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.418	-3.023	0.605	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168V	168	D	V	missense	possibly_wt-like	0.858470410917842	0.187309834828738	6	0.0764689198559007	0.708594082063597	1.00834673977209	1.03937561185357	1.06052335047195	0.616904464702726	0.65494068617493	NA	NA	0.880489385029536	0.898588967274334	0.670302597391101	0.694666140627272	0.686625244387774	0.60310828565753	0.61005125262687	NA	NA	0.666852853272677	0.673752341509525	NA	NA	p.Asp168Val	1	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.418	-4.114	1.696	0.008750337	NA	NA	NA	NA	4.06e-06	NA	NA
D168W	168	D	W	missense	possibly_low	0.694186717604932	0.212790362917862	6	0.0868713018884023	0.523922094613557	0.864451340596307	0.878508062035952	0.746359062840382	0.928276390740164	0.735011656210036	NA	NA	0.403350636419519	0.473614497383542	0.627635147903291	0.660401550406548	0.618699227827429	0.696275437425117	0.636571067979153	NA	NA	0.56870299148223	0.578174955415322	NA	NA	p.Asp168Trp	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.418	-4.581	2.163	0.008750337	NA	NA	NA	NA	NA	NA	NA
D168X	168	D	X	nonsense	low	0.0885737417976087	0.175520801749609	6	0.0716560672551243	-0.0518695692962148	0.229017052891432	0.0334196397668268	-0.023405599573818	0.135750293791366	0.419057515386709	NA	NA	-0.0659364029654635	0.0325570043800321	0.475574369892904	0.480398756044611	0.45226704802463	0.459139738989273	0.531925832998858	NA	NA	0.472168266122225	0.478980473663583	NA	NA	p.Asp168Ter	0	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D168Y	168	D	Y	missense	wt-like	1.16488437277811	0.178775847076408	6	0.0729849339451724	1.02183653083153	1.30793221472468	0.855508114019051	1.05205584955988	1.3228736688444	1.28754536554083	NA	NA	1.26149665633487	1.2098265823696	0.744489061653383	0.655502589772221	0.684794471031852	0.814344863156818	0.819572372208893	NA	NA	0.745227982370269	0.743750140936497	NA	NA	p.Asp168Tyr	1	27.4	22.6	3.7	0.881	110	53	-61.1	-37.2	40.1069518716578	-4.8	1	0	17.69	1	4	1	4	7	17.4073364682066	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.418	-4.1	1.682	0.008750337	NA	NA	NA	NA	NA	NA	NA
T169A	169	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr169Ala	1	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.582	-2.926	0.344	0.00720049	NA	NA	NA	NA	3.24e-05	NA	NA
T169C	169	T	C	missense	wt-like	0.91084646964575	0.128662236378605	6	0.052526138048823	0.807897130823078	1.01379580846842	1.05918212330238	0.986347022927407	0.953393419452625	0.961138322757901	NA	NA	0.735406168209494	0.7696117612247	0.684736176275566	0.698884903200983	0.67058744935015	0.70379082924539	0.711465095620475	NA	NA	0.637008499359934	0.644745177330639	NA	NA	p.Thr169Cys	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.582	-5.45	2.868	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169D	169	T	D	missense	low	0.450102092172094	0.140915167886486	6	0.0575283763900863	0.33734854635846	0.562855637985727	0.601475734353289	0.589644214217249	0.432041805416702	0.493179822020214	NA	NA	0.243091228806127	0.341179748218981	0.552432806339124	0.601394005400103	0.584815633090809	0.547794604514068	0.556475427996196	NA	NA	0.535736818112962	0.548390184682053	NA	NA	p.Thr169Asp	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.582	-3.691	1.109	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169E	169	T	E	missense	possibly_low	0.516527677128696	0.331073133149291	6	0.135160040626713	0.251618865351368	0.781436488906023	0.934809761768305	0.926620952834337	0.346457732259139	0.425002986703914	NA	NA	0.174019000574946	0.292255628631533	0.535641037017105	0.672393743190278	0.657673970046659	0.522186565811824	0.533894996123089	NA	NA	0.521528310264462	0.537387077911121	NA	NA	p.Thr169Glu	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.582	-2.917	0.335	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169F	169	T	F	missense	possibly_wt-like	0.802859956247838	0.305555807972872	6	0.12474263624623	0.558368881868648	1.04735103062703	1.12839809427158	1.01893564578614	0.875505800920404	0.841048288605843	NA	NA	0.694096305725651	0.259175602177417	0.674662152211886	0.713627819871736	0.677633493165852	0.680485685236567	0.671690811257919	NA	NA	0.628510851023505	0.529947331092391	NA	NA	p.Thr169Phe	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.582	-4.509	1.927	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169G	169	T	G	missense	wt-like	0.952410632745654	0.0741786618718785	6	0.0302833118980913	0.893056432092801	1.01176483339851	0.849017781081255	0.8771363738327	1.01571058903565	0.971972424566135	NA	NA	0.967319438402904	1.03330718955528	0.694382452291799	0.654120156840522	0.646974821654946	0.72243706132596	0.715053392094668	NA	NA	0.684714235863549	0.70405066872005	NA	NA	p.Thr169Gly	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.582	-3.592	1.01	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169H	169	T	H	missense	wt-like	1.14284247911491	0.160642530918076	3	0.0927470084688539	0.961061682842126	1.3246232753877	1.12057576983582	1.31345676673133	NA	NA	NA	NA	NA	0.994494900777579	0.711961674389513	0.711961674389513	0.741312425897239	NA	NA	NA	NA	NA	0.695321727636462	NA	NA	p.Thr169His	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.582	-1.956	-0.626	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169I	169	T	I	missense	possibly_wt-like	0.789812152272542	0.26202373754974	6	0.106970742915633	0.580153348758408	0.999470955786676	0.917967719773407	0.625727576487717	0.949003475443894	0.853579238456077	NA	NA	0.340603425487086	1.05199147798707	0.672323759669113	0.668806408963521	0.592617280698863	0.702477292135871	0.675841110374706	NA	NA	0.555795571787863	0.708252792790702	NA	NA	p.Thr169Ile	1	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.582	-2.802	0.22	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169K	169	T	K	missense	possibly_low	0.706527067700487	0.279540915687232	6	0.114122100944015	0.482851860010173	0.930202275390801	1.03985842209666	0.915586926349829	0.476275110096608	0.621817472722177	NA	NA	0.319091579951739	0.866532894985913	0.627184499858014	0.694768978615122	0.655288283655108	0.561029872904318	0.599080716060919	NA	NA	0.55137047600115	0.66654288349535	NA	NA	p.Thr169Lys	1	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.582	-2.646	0.064	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169L	169	T	L	missense	wt-like	1.07408966396713	0.176127779471066	6	0.0719038648722588	0.933160678468271	1.215018649466	1.07110570169916	0.888364391611118	1.14477276489034	1.240703883505	NA	NA	1.25796069104536	0.841630551051821	0.722962613549509	0.701424610731767	0.649402451247432	0.761054400654951	0.804058291963919	NA	NA	0.744500616367252	0.660942309556282	NA	NA	p.Thr169Leu	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.582	-2.215	-0.367	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169M	169	T	M	missense	wt-like	1.09633156330242	0.443354110552338	6	0.180998557703119	0.741580908950608	1.45108221765422	0.518852579029515	0.57162211812924	1.57545269103779	1.33504994067947	NA	NA	1.37098872374381	1.20602332719467	0.755322919736942	0.583795374954609	0.5809190438045	0.889920296027315	0.835306071457359	NA	NA	0.767751056244787	0.742894783229096	NA	NA	p.Thr169Met	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.582	-3.71	1.128	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169N	169	T	N	missense	possibly_low	0.390010737854994	0.621958245839094	6	0.253913390603713	-0.107650362920735	0.887671838630723	1.10412703595424	1.25489083677374	0.0861599619048164	0.131678636542798	NA	NA	-0.127478684813594	-0.109313359232036	0.453291162878313	0.708458114307066	0.728649782545373	0.444301567687588	0.436744835444498	NA	NA	0.459508706454813	0.447073619301813	NA	NA	p.Thr169Asn	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.582	-4.169	1.587	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169P	169	T	P	missense	low	-0.0561421407969432	0.186339626833837	6	0.076072834100588	-0.205242155835986	0.0929578742420998	0.18920498760482	0.174980626017232	-0.130241275087891	-0.195356583406628	NA	NA	-0.203569104635244	-0.171871495273949	0.438430361535813	0.513580843495521	0.495160484915348	0.379551070922607	0.328429504145907	NA	NA	0.443856520982918	0.433004202088709	NA	NA	p.Thr169Pro	1	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.582	-4.428	1.846	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169Q	169	T	Q	missense	wt-like	0.923851390093037	0.171860021902194	6	0.0701615601406527	0.786337259118216	1.06136552106786	0.640880526195176	0.899991635292916	1.0908909248255	1.08835201357826	NA	NA	0.988209057279833	0.834784183386537	0.674206943911696	0.609787177588813	0.651916398178941	0.744932145721041	0.753598762658094	NA	NA	0.689011336469187	0.659402551354205	NA	NA	p.Thr169Gln	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.582	-2.514	-0.068	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169R	169	T	R	missense	wt-like	0.882871272375684	0.0745980344257146	6	0.0304545200262624	0.823181509957756	0.942561034793612	0.756855336739404	0.950613607643542	0.946085218214912	0.916504961199674	NA	NA	0.890824736553961	0.836343773902612	0.665920175963232	0.634489669568888	0.66286146439932	0.701604105790495	0.69668235342868	NA	NA	0.668978887527143	0.659753305565257	NA	NA	p.Thr169Arg	1	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.582	-2.828	0.246	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169S	169	T	S	missense	wt-like	1.09245313699762	0.094858698634931	6	0.0387259015533374	1.01655176468423	1.168354509311	1.06817403988218	0.950242311563238	1.04162677180955	1.22636932212871	NA	NA	1.12459239569821	1.14371398090382	0.722973700223217	0.700800170371119	0.662781185816769	0.730191572031085	0.799310629725174	NA	NA	0.717066081247889	0.728881319198545	NA	NA	p.Thr169Ser	1	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.582	-3.404	0.822	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169T	169	T	T	synonymous	wt-like	1.04373976421106	0.257887626012893	6	0.105282182451548	0.837390478392249	1.25008905002987	1.4215539245812	1.13667376437459	0.840865361192789	1.17709541936692	NA	NA	0.698702768854816	0.987547346896027	0.698424536317502	0.776069651103475	0.70308986013014	0.670120745961307	0.782990922316159	NA	NA	0.629458423864293	0.693759212504863	NA	NA	p.Thr169=	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169V	169	T	V	missense	possibly_wt-like	0.835121255268093	0.215190997202283	6	0.0878513567310461	0.662935760082263	1.00730675045392	1.08184309915656	1.06438476041827	0.693558915648816	0.524579538241606	NA	NA	0.797284747783857	0.849076470359447	0.656177072492294	0.703711663181637	0.687460126665251	0.626044447423433	0.566875135604837	NA	NA	0.649737237176147	0.662616907808441	NA	NA	p.Thr169Val	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.582	-2.481	-0.101	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169W	169	T	W	missense	possibly_wt-like	0.795728619231066	0.210024687139489	6	0.0857422194799039	0.627676957095925	0.963780281366206	1.00507895364579	1.10438498126051	0.688561559972733	0.741439078386307	NA	NA	0.57586381713143	0.659043324989627	0.631624509362174	0.687360994618879	0.696108645196211	0.624549163630076	0.638699855094273	NA	NA	0.604189828158628	0.619878172678365	NA	NA	p.Thr169Trp	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.582	-5.753	3.171	0.00720049	NA	NA	NA	NA	NA	NA	NA
T169X	169	T	X	nonsense	low	0.141476465478086	0.0983176727303719	6	0.0401380218145599	0.062807388310866	0.220145542645307	0.10624293309175	0.324896296933738	0.0917396862381661	0.0374949700029611	NA	NA	0.152797787668103	0.1356871189338	0.499042308360342	0.495910027939602	0.527574017408487	0.445971104920447	0.405550840358109	NA	NA	0.517162999084224	0.502174588781081	NA	NA	p.Thr169Ter	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T169Y	169	T	Y	missense	wt-like	1.16426174971002	0.310408507533382	6	0.126723742545942	0.915887778333843	1.41263572108619	0.926631790505726	1.32545288872042	1.0596389791942	1.58937371657265	NA	NA	1.34045646825297	0.744016655014135	0.739743611688561	0.67065184537144	0.743906128660319	0.735581094716803	0.919539090907797	NA	NA	0.761470416356899	0.638988800132173	NA	NA	p.Thr169Tyr	0	24	22.3	5.4	0.924	107.7	51.4	-64.4	-42.7	5.52147239263804	-3.6	1	0	17.11	1	4	0	0	7	15.007223691188	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.582	-3.668	1.086	0.00720049	NA	NA	NA	NA	NA	NA	NA
M170A	170	M	A	missense	possibly_low	0.559321701235815	0.234580414127252	6	0.0957670530437556	0.371621726364517	0.747021676107113	0.773926027496539	0.917605295186538	0.455717144813468	0.422493912500718	NA	NA	0.303655106855614	0.482532720562014	0.567529649122283	0.638125705700731	0.655724678752911	0.554878621261494	0.533063981030543	NA	NA	0.548195115154163	0.580180676983073	NA	NA	p.Met170Ala	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-2.004	-3.542	1.538	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170C	170	M	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met170Cys	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-2.004	-3.354	1.35	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170D	170	M	D	missense	low	0.196738614501021	0.124339905987882	6	0.0507615540559903	0.0972477967519965	0.296229432250045	0.221461546382679	0.379612446791855	0.0691726485554375	0.293912268990081	NA	NA	0.138397711496805	0.0778750647892653	0.50233903655413	0.520451450834957	0.539404292992641	0.439218708673655	0.490477242764476	NA	NA	0.514200830343785	0.489172572398094	NA	NA	p.Met170Asp	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-2.004	-4.422	2.418	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170E	170	M	E	missense	low	-0.00750325911288474	0.159145176551956	6	0.0649707462629058	-0.13484358183687	0.119837063611101	-0.0357017049245159	0.0474452341244797	0.0671956263376234	0.233991492723317	NA	NA	-0.171338912973929	-0.186611289964284	0.458081214805874	0.465675994654639	0.467585832153107	0.438627153964921	0.470631249620353	NA	NA	0.450486434957109	0.42968920048772	NA	NA	p.Met170Glu	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-2.004	-4.266	2.262	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170F	170	M	F	missense	possibly_low	0.300281946460528	0.684497673131065	2	0.484012946377389	-0.64836599649027	1.24892988941133	0.784294892837916	NA	NA	NA	NA	NA	NA	-0.183730999916861	0.53533562161884	0.640334261263235	NA	NA	NA	NA	NA	NA	0.430336981974444	NA	NA	p.Met170Phe	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-2.004	-2.973	0.969	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170G	170	M	G	missense	low	0.0828579533494332	0.155775382384597	6	0.0635950335548661	-0.0417860220137206	0.207501928712587	-0.158668233556851	-0.00935524838842516	0.117037223043071	0.100445551621651	NA	NA	0.142419776476856	0.305268650900298	0.454422703393726	0.439484275322626	0.455304899317317	0.453540507470134	0.426400316767781	NA	NA	0.515028189519819	0.540313725843534	NA	NA	p.Met170Gly	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-2.004	-4.153	2.149	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170H	170	M	H	missense	low	0.00731703638455058	0.334403640617483	6	0.136519714606979	-0.260256687424816	0.274890760193917	-0.0916828034386198	-0.287734719760422	0.00870031835633307	-0.35771768886505	NA	NA	0.241318193126488	0.531018918888574	0.437438284875398	0.45375208953601	0.395115981203716	0.421124480214786	0.274654877270997	NA	NA	0.535372095676536	0.591085294615488	NA	NA	p.Met170His	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-2.004	-4.093	2.089	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170I	170	M	I	missense	possibly_wt-like	0.784016903768054	0.223969015028693	6	0.0914349675023391	0.604807660535879	0.963226147000229	1.11531693556637	0.967844141195223	0.590224821194987	0.528693994415907	NA	NA	0.71684598435094	0.7851755458849	0.640718035425617	0.710841549159249	0.666586908548936	0.595125336046679	0.568237859423091	NA	NA	0.633190575358102	0.648245495493133	NA	NA	p.Met170Ile	1	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-2.004	-1.936	-0.068	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170K	170	M	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met170Lys	1	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-2.004	-4.166	2.162	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170L	170	M	L	missense	wt-like	1.06112873297086	0.13121769709267	6	0.0535694005166874	0.95613463728475	1.16612282865697	0.896701181144366	0.900930007543939	1.12826324882445	1.12722176593319	NA	NA	1.10115808787285	1.21249810650635	0.728298247937122	0.664276662396463	0.652119285303837	0.756114505756606	0.766472575162049	NA	NA	0.712245525212743	0.744350970661501	NA	NA	p.Met170Leu	1	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-2.004	-1.473	-0.531	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170N	170	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met170Asn	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-2.004	-3.778	1.774	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170P	170	M	P	missense	low	0.206129264279518	0.250353138889466	6	0.102206240963887	0.0058087129950779	0.406449815563958	0.242267958735353	0.507691960684895	0.175804728812476	0.432847184095419	NA	NA	-0.175347574491944	0.0535113278409098	0.504288161518487	0.52488319107117	0.567096591335419	0.471124626882243	0.536493024675989	NA	NA	0.44966183294123	0.483693131965804	NA	NA	p.Met170Pro	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-2.004	-4.506	2.502	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170Q	170	M	Q	missense	low	0.444527799029196	0.181357323432329	6	0.0740388172543501	0.299414383752727	0.589641214305665	0.488613927540373	0.747788730762491	0.396249713377284	0.475690077045378	NA	NA	0.199683215799813	0.359141129649837	0.551556241315668	0.577354579385351	0.619008338858747	0.537085073588936	0.550682756731094	NA	NA	0.526807569567168	0.552429725900242	NA	NA	p.Met170Gln	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-2.004	-4.542	2.538	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170R	170	M	R	missense	low	-0.0546555213411256	0.0873166567797952	6	0.0356468758593712	-0.124522114186864	0.0152110715046123	-0.0391402987699792	-0.189379478517363	0.00865901390146408	-0.0333955470161111	NA	NA	-0.122980817517161	0.0483039998723961	0.440773030941974	0.464943578395525	0.416381541958055	0.4211121213022	0.38207162659625	NA	NA	0.460433940581748	0.482521996212888	NA	NA	p.Met170Arg	1	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-2.004	-4.44	2.436	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170S	170	M	S	missense	low	0.0450161364447496	0.157561209730911	6	0.0643240945160624	-0.0810567721448831	0.171089045034382	0.201667701810877	0.232922824381727	0.111366063040986	-0.0656392128835552	NA	NA	-0.140861065748067	-0.0693594919334704	0.456407592935001	0.516235386290464	0.507688270155742	0.451843611313385	0.371392399596622	NA	NA	0.4567558827888	0.456059303081201	NA	NA	p.Met170Ser	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-2.004	-3.999	1.995	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170T	170	M	T	missense	wt-like	0.837220499527679	0.132714686457924	6	0.0541805438658952	0.731028584887732	0.943412414167626	0.91766572361159	1.02009634895232	0.784522407832818	0.685047868705876	NA	NA	0.909260099305227	0.706730548758237	0.661002086579045	0.668742084152553	0.677884450851344	0.653262089005538	0.62002286807187	NA	NA	0.672771135193812	0.630603099752371	NA	NA	p.Met170Thr	1	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-2.004	-3.126	1.122	0.006646728	NA	NA	NA	NA	4.06e-06	NA	NA
M170V	170	M	V	missense	wt-like	1.04690442777799	0.218340963077417	6	0.0891373249145888	0.872198481267155	1.22161037428883	1.19011077890962	1.03895053698536	1.26722827002359	1.2165674814998	NA	NA	0.748744494715403	0.819825004534198	0.7043667469968	0.72677254578408	0.681960948209521	0.79769492498454	0.796064222151029	NA	NA	0.639752260806441	0.656038209931085	NA	NA	p.Met170Val	1	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-2.004	-2.078	0.074	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170W	170	M	W	missense	low	0.136398433280115	0.0935789869141492	6	0.0382034614310416	0.0615210247905082	0.211275841769721	0.106581171800849	0.0126648115731303	0.203157622587183	0.163858481938234	NA	NA	0.0645381753867179	0.267590336394574	0.487645547721134	0.495982072368558	0.46006589544735	0.479309023073711	0.447402924856651	NA	NA	0.499007548971794	0.531839817248936	NA	NA	p.Met170Trp	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-2.004	-5.567	3.563	0.006646728	NA	NA	NA	NA	NA	NA	NA
M170X	170	M	X	nonsense	low	-0.14361794701774	0.0737373980260395	6	0.0301031666873841	-0.202619069545619	-0.0846168244898613	-0.178700220218681	-0.146806507415694	-0.195322402413193	-0.000631629445329208	NA	NA	-0.196783958599444	-0.143462964014098	0.43040190309057	0.435217486805906	0.425586319375234	0.360077821218031	0.39292316297471	NA	NA	0.445252259953148	0.439393322737038	NA	NA	p.Met170Ter	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M170Y	170	M	Y	missense	low	-0.1142640738041	0.1351295836397	6	0.0551664215120012	-0.222388273123578	-0.00613987448462171	-0.188462163746871	-0.0183708935452056	0.113380468997424	-0.167874509881292	NA	NA	-0.249196767036096	-0.175060577612557	0.433804442068124	0.433138204843009	0.453355610724274	0.452446351797581	0.337531673322454	NA	NA	0.43447067929324	0.432286972759517	NA	NA	p.Met170Tyr	0	25.7	22.9	8.7	0.931	107.9	51.5	-58.2	-45.9	0	-4.6	1	0	17.64	0	0	0	0	7	14.5025383110271	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-2.004	-4.363	2.359	0.006646728	NA	NA	NA	NA	NA	NA	NA
F171A	171	F	A	missense	wt-like	1.04974410036389	0.132056616328452	6	0.0539118878605329	0.944078741818679	1.15540945890909	0.903677982713132	1.01629050373605	1.058478593752	1.2575499121918	NA	NA	0.929264479000525	1.1332031307898	0.701789497901336	0.665762712548132	0.677061582322474	0.735233889983296	0.809637761901617	NA	NA	0.676886137607715	0.726517413480198	NA	NA	p.Phe171Ala	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-3.753	-2.582	-1.171	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171C	171	F	C	missense	wt-like	0.91354525219896	0.121135057114864	6	0.0494531799823856	0.816618800512507	1.01047170388541	1.02341375485955	0.980404725041531	1.01704547933818	0.845571191794358	NA	NA	0.904805431198168	0.710030930961966	0.672521800834172	0.691266284722946	0.669302654609012	0.722836480531769	0.673188814309001	NA	NA	0.671854787359342	0.631345360585652	NA	NA	p.Phe171Cys	1	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-3.753	-3.531	-0.222	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171D	171	F	D	missense	possibly_wt-like	0.833526194775992	0.230971217422256	6	0.094293604658993	0.648714125671908	1.01833826388008	0.941603524514323	1.14103878722176	0.725547137395422	0.781556293577171	NA	NA	0.94388349748736	0.46752792845992	0.662913819209092	0.673840806297866	0.704033629444081	0.635615803287683	0.651986832120317	NA	NA	0.679893343893465	0.576806077072698	NA	NA	p.Phe171Asp	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-3.753	-3.235	-0.518	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171E	171	F	E	missense	possibly_low	0.474078758469883	0.312513790469402	6	0.127583220705515	0.224020240855448	0.724137276084317	0.864041242384035	0.885994438481525	0.244172619869292	0.234858516885441	NA	NA	0.283890595324653	0.33151513787435	0.545173027188425	0.657320135616977	0.648890039487516	0.491581325606438	0.470918411380419	NA	NA	0.544129454838855	0.546216599537994	NA	NA	p.Phe171Glu	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-3.753	-3.296	-0.457	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171G	171	F	G	missense	wt-like	1.02868219466102	0.131167253113597	6	0.0535488068484667	0.923728461822937	1.13363592749911	0.8091821562348	0.999923489655825	1.08829124826907	1.19442862258499	NA	NA	0.986610400273198	1.09365725094826	0.703152985646642	0.645635217751826	0.673522841245829	0.744154283492543	0.788731746345208	NA	NA	0.688682484610668	0.717623486682615	NA	NA	p.Phe171Gly	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-3.753	-3.128	-0.625	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171H	171	F	H	missense	wt-like	1.23647954217002	0.20591270123307	2	0.145602267374343	0.951104342048932	1.5218547422911	1.38208180954436	1.09087727479567	NA	NA	NA	NA	NA	NA	0.730425129617926	0.767662139157057	0.693188120078796	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe171His	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-3.753	-3.652	-0.101	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171I	171	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe171Ile	1	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-3.753	-2.722	-1.031	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171K	171	F	K	missense	wt-like	1.01603437130851	0.142520758051501	6	0.0581838558301389	0.901996109399764	1.13007263321725	0.988517585013273	1.15231094981393	0.87901754999706	1.18785291967706	NA	NA	0.835551782785523	1.05295544056419	0.695152123568953	0.683833443473041	0.706470803664865	0.681536453246895	0.786553848077543	NA	NA	0.657608960458914	0.708469589398362	NA	NA	p.Phe171Lys	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-3.753	-2.589	-1.164	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171L	171	F	L	missense	wt-like	0.983618877496536	0.108162434975986	6	0.0441571291713549	0.897072494659997	1.07016526033307	0.837709375003854	1.06007506967897	1.1234067926167	0.936857039534655	NA	NA	0.90343928868148	1.04022569946356	0.694975680695689	0.651711480257016	0.686528320804266	0.754661381198079	0.703423040587113	NA	NA	0.671573764911282	0.705606651819153	NA	NA	p.Phe171Leu	1	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-3.753	-2.27	-1.483	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171M	171	F	M	missense	possibly_low	0.405421839048202	0.794657159042142	6	0.324417426683825	-0.230424633209257	1.04126831130566	1.36687167405942	1.00769571347585	0.163389328599416	0.825121923298487	NA	NA	-0.709538719738637	-0.221008885405316	0.566912845131894	0.764422399009438	0.675203287511346	0.467409752870877	0.666415937392911	NA	NA	0.339776003654921	0.421953130457385	NA	NA	p.Phe171Met	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-3.753	-3.05	-0.703	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171N	171	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe171Asn	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-3.753	-3.081	-0.672	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171P	171	F	P	missense	low	0.388310344504788	0.331181203277587	6	0.13520416007184	0.123315060203994	0.653305628805583	0.766030246033727	0.82202099057572	0.290276615745979	0.215828786260523	NA	NA	-0.00858410601161615	0.244289534424399	0.515987882666083	0.636443913962109	0.635058227111158	0.50537633286865	0.46461569090438	NA	NA	0.483965924635149	0.526599432463515	NA	NA	p.Phe171Pro	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-3.753	-4.058	0.305	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171Q	171	F	Q	missense	possibly_wt-like	0.941853001151836	0.322793955085303	6	0.131780080335644	0.683568789814179	1.20013721248949	1.11010253416165	1.50768000232076	0.742466669934628	0.681431569704806	NA	NA	0.92160675859355	0.687830472195619	0.657994643463914	0.709730888074515	0.78330577535306	0.640678381266301	0.618825135838515	NA	NA	0.675310905661528	0.626352444612312	NA	NA	p.Phe171Gln	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-3.753	-3.027	-0.726	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171R	171	F	R	missense	wt-like	0.977145474464286	0.0533173095440271	6	0.0217667004734817	0.934483525473991	1.01980742345458	0.956001690274534	1.00607317961916	0.927918871194463	1.00989575021972	NA	NA	1.05003432049629	0.912949034981556	0.686575202082118	0.676907597892958	0.674852476595026	0.696168462213195	0.727613744410077	NA	NA	0.701729106840029	0.67698194195104	NA	NA	p.Phe171Arg	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-3.753	-2.99	-0.763	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171S	171	F	S	missense	possibly_low	0.719385560832918	0.164774129290004	6	0.0672687565953159	0.587541220621308	0.851229901044529	0.585628375184038	0.655480794563253	0.828446555140805	0.519894502802799	NA	NA	0.964891602904044	0.761971534402572	0.621038577830199	0.598018537391604	0.599050276628981	0.666404852871838	0.565323433724598	NA	NA	0.684214817781581	0.643026879031418	NA	NA	p.Phe171Ser	1	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-3.753	-2.747	-1.006	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171T	171	F	T	missense	wt-like	1.18433116568779	0.127306249057237	6	0.0519725585429839	1.08246682275914	1.28619550861644	1.13123171400882	1.31614656241681	1.28254907026087	1.11898677283619	NA	NA	1.27118426373925	0.985888610864809	0.744557381877231	0.714231377390004	0.741893991382143	0.802279138272721	0.763745113558125	NA	NA	0.747220772372318	0.693386160320988	NA	NA	p.Phe171Thr	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-3.753	-2.757	-0.996	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171V	171	F	V	missense	wt-like	0.925192165180243	0.0684703146960618	6	0.0279528889221899	0.870405509628903	0.979978820731584	0.85734803235384	0.967622165963029	0.962475781826384	0.990842376405953	NA	NA	0.950981208513953	0.821883426018301	0.673946146979786	0.655894490114165	0.666538914891185	0.706508408329841	0.721303193218334	NA	NA	0.681353379068387	0.656501151963771	NA	NA	p.Phe171Val	1	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-3.753	-2.843	-0.91	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171W	171	F	W	missense	wt-like	1.08384667297656	0.126491607843358	6	0.0516399826600762	0.982634166800539	1.18505917915258	1.0589670622453	0.946693902800343	1.19124193257865	1.21042216710459	NA	NA	1.17122272286544	0.92453225026505	0.712748635814167	0.698839095460383	0.662013978079032	0.774958672801853	0.794028870225466	NA	NA	0.726658176167951	0.679587024180209	NA	NA	p.Phe171Trp	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-3.753	-4.337	0.584	0.009087887	NA	NA	NA	NA	NA	NA	NA
F171X	171	F	X	nonsense	low	0.319573072124588	0.178547807777106	6	0.0728918372910741	0.176707696267129	0.462438447982046	0.138009548162558	0.359711616406595	0.43294853615918	0.570046418911357	NA	NA	0.0976970053710631	0.319025307736772	0.539254558764097	0.502676277872138	0.535101499239396	0.548065911955852	0.58193394255419	NA	NA	0.505828488561331	0.543407618288798	NA	NA	p.Phe171Ter	0	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F171Y	171	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe171Tyr	1	27.4	26.1	7.4	0.838	103.8	58.4	-59.4	-34	15.7894736842105	-3.6	1	0	19.1	0	0	0	0	7	18.3471999153968	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-3.753	-3.038	-0.715	0.009087887	NA	NA	NA	NA	NA	NA	NA
S172A	172	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Ala	1	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.087	-2.224	0.137	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172C	172	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Cys	1	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.087	-4.485	2.398	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172D	172	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Asp	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.087	-2.726	0.639	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172E	172	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Glu	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.087	-2.558	0.471	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172F	172	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Phe	1	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.087	-4.177	2.09	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172G	172	S	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Gly	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.087	-2.648	0.561	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172H	172	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172His	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.087	-3.391	1.304	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172I	172	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Ile	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.087	-3.975	1.888	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172K	172	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Lys	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.087	-2.784	0.697	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172L	172	S	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Leu	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.087	-3.67	1.583	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172M	172	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Met	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.087	-4.129	2.042	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172N	172	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Asn	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.087	-2.841	0.754	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172P	172	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Pro	1	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.087	-3.472	1.385	0.008685925	1.092651757	0.015275252252638	NA	NA	2.84e-05	NA	NA
S172Q	172	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Gln	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.087	-2.572	0.485	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172R	172	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Arg	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.087	-2.656	0.569	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172T	172	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Thr	1	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.087	-2.579	0.492	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172V	172	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Val	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.087	-3.474	1.387	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172W	172	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Trp	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.087	-5.936	3.849	0.008685925	NA	NA	NA	NA	NA	NA	NA
S172X	172	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Ter	0	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S172Y	172	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser172Tyr	1	24	27.3	6.1	0.714	107	49.4	-69.5	-18.9	37.7622377622378	-2.3	1	0	20.32	1	3	0	0	6	18.8480493133203	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.087	-4.762	2.675	0.008685925	NA	NA	NA	NA	NA	NA	NA
L173A	173	L	A	missense	low	0.411908786426689	0.257503298952007	6	0.105125281585962	0.205867020653571	0.617950552199806	0.783026282236613	0.668454182636141	0.305706149188428	0.122348993354461	NA	NA	0.350654180865998	0.241262930278491	0.541890903945464	0.640064048765732	0.601855275821366	0.509993080763137	0.433654821491265	NA	NA	0.557863063171038	0.525918744719891	NA	NA	p.Leu173Ala	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.612	-3.182	1.57	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173C	173	L	C	missense	wt-like	1.10335054286192	0.131627402663331	6	0.0537366621155034	0.998028620466132	1.2086724652577	1.32443214168169	1.14399221866883	1.15129799236645	0.984787973675359	NA	NA	1.03502551551154	0.980567415267635	0.711985073835832	0.755382830819765	0.704672196083516	0.76300684661346	0.719297951588149	NA	NA	0.698641719493718	0.692189415570169	NA	NA	p.Leu173Cys	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.612	-3.722	2.11	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173D	173	L	D	missense	possibly_low	0.375524245573695	0.501695288402074	3	0.289653909810104	-0.192186985635322	0.943235476782713	-0.0949849601886116	0.318094756173541	NA	NA	NA	NA	NA	0.903462940736156	0.526103444245013	0.453048734210393	0.526103444245013	NA	NA	NA	NA	NA	0.674848505341421	NA	NA	p.Leu173Asp	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.612	-4.364	2.752	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173E	173	L	E	missense	low	0.0198976023001925	0.263547446794201	6	0.107592794609848	-0.190980400131126	0.230775604731511	-0.15955671368026	-0.367935749734086	0.3301164772429	0.268435980627861	NA	NA	-0.0333883120553272	0.0817139314000676	0.480451485493227	0.439295030149299	0.377775574592839	0.517297017143946	0.482039397401402	NA	NA	0.478863573585053	0.49003593917003	NA	NA	p.Leu173Glu	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.612	-4.159	2.547	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173F	173	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu173Phe	1	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.612	-3.447	1.835	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173G	173	L	G	missense	low	0.111979930670443	0.0748233809222936	6	0.0305465173482528	0.05210985681474	0.171850004526147	0.128816347065975	0.222850028489551	0.129215888634908	0.106566446355764	NA	NA	0.0939672235148122	-0.00953635003835065	0.485115876708908	0.500718137347537	0.505510413131511	0.457184546931113	0.428427580807024	NA	NA	0.505061253507029	0.469513616070279	NA	NA	p.Leu173Gly	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.612	-3.442	1.83	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173H	173	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu173His	1	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.612	-3.934	2.322	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173I	173	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu173Ile	1	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.612	-1.991	0.379	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173K	173	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu173Lys	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.612	-3.638	2.026	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173L	173	L	L	synonymous	wt-like	0.930178443173578	0.177982910237142	6	0.0726612188360966	0.787765071182046	1.07259181516511	1.24609048031936	0.974164403646203	0.766398117241775	0.767995232334325	NA	NA	0.874797420349508	0.951625005150303	0.666817705466057	0.738696153321199	0.667953423677525	0.647839029342887	0.647495356121168	NA	NA	0.665681987254588	0.685680224778092	NA	NA	p.Leu173=	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173M	173	L	M	missense	wt-like	1.07769876937095	0.135081193285273	6	0.0551466662325314	0.969613289687739	1.18578424905416	1.32355289252616	0.916253213556694	1.07009501548936	1.08027891098015	NA	NA	1.01052660131037	1.06548598236298	0.724998712204002	0.755195551831241	0.655432342791137	0.738709697647697	0.750924919814326	NA	NA	0.693602168524811	0.711287726760307	NA	NA	p.Leu173Met	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.612	-3.044	1.432	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173N	173	L	N	missense	low	0.0376609726736249	0.310677381063183	4	0.155338690531591	-0.266797266173907	0.342119211521157	-0.0774033572628962	0.429205094551119	NA	NA	NA	NA	-0.306484445607962	0.105326599014239	0.476070028502577	0.456793594005648	0.550126807121674	NA	NA	NA	NA	0.42268631310939	0.495346462999505	NA	NA	p.Leu173Asn	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.612	-3.635	2.023	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173P	173	L	P	missense	low	0.133699942674001	0.331357247953128	6	0.135276030009675	-0.131436204116521	0.398836089464523	0.375428990669562	0.65213804884744	-0.153671438885757	-0.203871745787851	NA	NA	-0.0236266300525103	0.15580243125312	0.493785076672989	0.553246327065764	0.598327535662587	0.372540414392729	0.325609249390086	NA	NA	0.480871601107885	0.506698552238093	NA	NA	p.Leu173Pro	1	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.612	-3.874	2.262	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173Q	173	L	Q	missense	possibly_low	0.606614705276201	0.215729761519426	6	0.0880713063424827	0.43399811677354	0.779231293778861	0.446924337776837	0.607983334463504	0.881760159162189	0.489140904838896	NA	NA	0.364361474237516	0.849518021178261	0.578627757390664	0.568474748049963	0.588780766731365	0.682357083056328	0.555137722984944	NA	NA	0.560682722974092	0.662716213239897	NA	NA	p.Leu173Gln	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.612	-3.075	1.463	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173R	173	L	R	missense	low	0.520761269521808	0.140149558361117	6	0.0572158176101913	0.408620327659821	0.632902211383796	0.589472790547377	0.748119654886479	0.477628692004285	0.527198698696867	NA	NA	0.335141374315724	0.447006406680119	0.569966684099154	0.598837393134806	0.619079888549183	0.561434884918816	0.567742611690378	NA	NA	0.554672000145184	0.572190756507929	NA	NA	p.Leu173Arg	1	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.612	-2.823	1.211	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173S	173	L	S	missense	possibly_low	0.590140082478663	0.186319169349177	6	0.0760644823674487	0.441056436535781	0.739223728421544	0.747283893570746	0.823333591109585	0.677938878928994	0.512490599712134	NA	NA	0.373045476478925	0.406748055071592	0.59225364592383	0.632450963948227	0.635342026795306	0.621370698090245	0.562871232349186	NA	NA	0.562469066301406	0.563136593757416	NA	NA	p.Leu173Ser	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.612	-3.298	1.686	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173T	173	L	T	missense	wt-like	0.987160957893047	0.0713883262674793	6	0.0291441621577749	0.930039449704213	1.04428246608188	1.00325245218968	1.02901642552628	0.873546252490769	0.926115320993909	NA	NA	1.04199829942318	1.04903699673446	0.693418646932229	0.68697195205559	0.67981307639198	0.679899358947414	0.699865341808868	NA	NA	0.700076056527163	0.707588325592329	NA	NA	p.Leu173Thr	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.612	-3.141	1.529	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173V	173	L	V	missense	wt-like	1.21281361198308	0.139628110008263	6	0.0570029372115737	1.1010899080354	1.32453731593076	1.31518030630842	1.01933260362121	1.13255389138292	1.18514212515929	NA	NA	1.41851855360537	1.20615419182125	0.755405265824376	0.753412201266359	0.677719320121813	0.757398330382393	0.785656022435644	NA	NA	0.777528183433524	0.742924214876942	NA	NA	p.Leu173Val	1	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.612	-2.275	0.663	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173W	173	L	W	missense	possibly_wt-like	0.86354706244578	0.189317385807492	6	0.0772884991109963	0.712064387769071	1.01502973712249	0.542744313156904	0.728529586425819	0.999096377801289	1.01219144150655	NA	NA	0.911514332793524	0.98720632299059	0.683458679093006	0.588884284933443	0.614844285181566	0.717465840062473	0.728374086254393	NA	NA	0.673234842461277	0.693682515724735	NA	NA	p.Leu173Trp	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.612	-3.583	1.971	0.007023238	NA	NA	NA	NA	NA	NA	NA
L173X	173	L	X	nonsense	low	-0.419262902701574	0.251975784039562	4	0.125987892019781	-0.666194633548466	-0.172331171854682	NA	-0.426888280879974	-0.338785483552203	-0.154618403287709	NA	NA	NA	-0.75675944308641	0.329536831066373	NA	0.36502934351394	0.317151514971922	0.341922147160824	NA	NA	NA	0.301462038569373	NA	NA	p.Leu173Ter	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L173Y	173	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu173Tyr	0	22.7	27.2	9.7	0.476	92.6	100.2	-97.5	-5.8	2.09424083769634	-4.9	0	0	21.74	0	0	0	0	6	17.3068525369444	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.612	-4.474	2.862	0.007023238	NA	NA	NA	NA	NA	NA	NA
L174A	174	L	A	missense	possibly_wt-like	0.84296108113711	0.267147901890466	6	0.109062674247791	0.629202167553816	1.0567199947204	1.22546933731667	1.10848991016345	0.522113684014677	0.71585690923149	NA	NA	0.764205087534912	0.721631558561454	0.638443471036666	0.734303875228626	0.696996179138222	0.5747454619344	0.630226941602664	NA	NA	0.642932583202922	0.633954358870411	NA	NA	p.Leu174Ala	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.537	-2.659	1.122	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174C	174	L	C	missense	possibly_low	0.478659313351811	0.41999112665382	6	0.171460659466414	0.142602596032154	0.814716030671469	0.976767377621285	1.04822143015733	0.226041159785744	0.33326531802183	NA	NA	0.132129905614498	0.155530688910181	0.509774473926024	0.681330663753007	0.683965424427604	0.486156120724066	0.50351112499937	NA	NA	0.512911510868328	0.506637436983721	NA	NA	p.Leu174Cys	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.537	-3.635	2.098	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174D	174	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu174Asp	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.537	-4.3	2.763	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174E	174	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu174Glu	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.537	-3.658	2.121	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174F	174	L	F	missense	wt-like	0.971414973859891	0.0852679326601703	6	0.0348104877399023	0.903187671605409	1.03964227611437	0.920323493682618	0.913213482122862	1.13689274171829	0.938126402236659	NA	NA	0.931663067665901	0.988270655733016	0.685650712599236	0.669308185908239	0.654775117078851	0.758696579498285	0.703843458429653	NA	NA	0.677379539467624	0.693921885730848	NA	NA	p.Leu174Phe	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.537	-4.34	2.803	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174G	174	L	G	missense	possibly_low	0.63373159185131	0.118143115404931	6	0.048231724894138	0.539199148146556	0.728264035556065	0.698672926607516	0.808544954957862	0.66407839390136	0.608287680527149	NA	NA	0.469480841124637	0.55332475398934	0.606662671451968	0.622096887783603	0.632144549603612	0.617223433021824	0.594599596491498	NA	NA	0.582306310162361	0.596101909882112	NA	NA	p.Leu174Gly	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.537	-3.531	1.994	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174H	174	L	H	missense	low	0.00862779765327296	0.565202774302321	4	0.28260138715116	-0.545260743144061	0.562516338450607	0.0765385482731296	0.76609430439009	NA	NA	NA	NA	-0.544366463268533	-0.263755198781594	0.450961225971886	0.48958303051394	0.62296621932552	NA	NA	NA	NA	0.373752774963862	0.412339421429832	NA	NA	p.Leu174His	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.537	-5.287	3.75	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174I	174	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu174Ile	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.537	-2.419	0.882	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174K	174	L	K	missense	low	0.428520551241698	0.24630929842547	5	0.110152866953927	0.212624899218169	0.644416203265227	0.219834632967998	0.33548219042842	0.459067136853628	NA	NA	NA	0.287735223821198	0.840483572137247	0.544920314429845	0.520104920278969	0.529862812173312	0.55588098913967	NA	NA	NA	0.544920314429845	0.66068435230396	NA	NA	p.Leu174Lys	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.537	-4.084	2.547	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174L	174	L	L	synonymous	wt-like	0.941654365286573	0.0774155655673945	6	0.0316047722981819	0.879710149842548	1.0035985807306	0.937326677551236	1.05053857489115	0.964075030265338	0.851919036380248	NA	NA	0.856539994854341	0.989526877777128	0.679878831704421	0.672929843155871	0.684466418390822	0.706986927456219	0.675291245018021	NA	NA	0.661926342184427	0.694204411924388	NA	NA	p.Leu174=	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174M	174	L	M	missense	possibly_wt-like	0.828186946560512	0.177677048968357	6	0.072536351495996	0.686018310058422	0.970355583062602	1.02211531865259	1.05883455936592	0.697866258413465	0.818272894037427	NA	NA	0.755053966622941	0.616978682270728	0.652598831786672	0.690989719408128	0.686260107874327	0.62733326900146	0.664147512378626	NA	NA	0.641050151194718	0.610417772388691	NA	NA	p.Leu174Met	1	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.537	-2.269	0.732	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174N	174	L	N	missense	low	-0.163613425359473	0.224143810149775	6	0.0915063273117023	-0.342962531247943	0.0157356805289976	0.104121226354292	0.0462363107397302	-0.368978734494505	-0.317778822394856	NA	NA	-0.0457599861051986	-0.399520546256299	0.424565021452571	0.495458107014531	0.467324448688832	0.308117241302175	0.287882784510096	NA	NA	0.476318657453951	0.381805594216311	NA	NA	p.Leu174Asn	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.537	-4.349	2.812	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174P	174	L	P	missense	low	-0.190153582716794	0.194347063467966	6	0.079341856417469	-0.345660763761582	-0.034646401672007	0.0130439834208399	0.0115219570532698	-0.199894101133787	-0.132103653590755	NA	NA	-0.435977138251315	-0.397512543799019	0.389153103034003	0.47605876630793	0.459818796849265	0.358709900371865	0.349379119449336	NA	NA	0.396049009132626	0.38225719693538	NA	NA	p.Leu174Pro	1	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.537	-4.428	2.891	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174Q	174	L	Q	missense	low	0.0166117475482935	0.132807018211416	6	0.0542182381464137	-0.089654046523893	0.12287754162048	0.162479294896172	0.207370293327257	-0.0858039127498559	-0.0931533935660624	NA	NA	-0.056603788760263	-0.0346180078574874	0.468980373197691	0.507888303825059	0.502163512199802	0.392847396425637	0.362279596405284	NA	NA	0.474088032221819	0.463872714173564	NA	NA	p.Leu174Gln	1	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.537	-4.486	2.949	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174R	174	L	R	missense	low	0.477630596486617	0.181793677480395	6	0.0742169580485103	0.332168031669417	0.623093161303818	0.622786570973979	0.697766607980727	0.554206420677883	0.456918771302557	NA	NA	0.247874921984261	0.286230286000295	0.564406858903246	0.605933187384888	0.608192967175118	0.584348090229728	0.544465627576763	NA	NA	0.536720848074162	0.536031969452103	NA	NA	p.Leu174Arg	1	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.537	-3.792	2.255	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174S	174	L	S	missense	possibly_wt-like	0.721271520830583	0.308800212858687	6	0.126067158994436	0.474184429568204	0.968358612092962	1.00712257365291	0.676295691292666	0.62570125328952	0.278436512333131	NA	NA	1.13795035865719	0.60212273575808	0.606408532425872	0.687796283166446	0.603550702283988	0.605740416780471	0.485351612229474	NA	NA	0.719813882012438	0.607076648071273	NA	NA	p.Leu174Ser	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.537	-2.527	0.99	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174T	174	L	T	missense	possibly_low	0.689729029800243	0.217761286890033	6	0.0889006731020669	0.515486912318823	0.863971147281663	0.93165425644866	0.900204372658401	0.698414268084786	0.362409167656224	NA	NA	0.718008590240578	0.52768352371281	0.630463485503015	0.671721624438923	0.651962394501183	0.627497241716881	0.513163680858504	NA	NA	0.633429729289148	0.590335159313072	NA	NA	p.Leu174Thr	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.537	-2.118	0.581	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174V	174	L	V	missense	wt-like	0.894125710045902	0.0753955996449341	6	0.0307801246635422	0.833797774265706	0.954453645826098	0.849985715549069	0.81268868172641	0.899022637119856	0.976548036172453	NA	NA	0.834855279402279	0.991653910305345	0.672493980813986	0.654326325691466	0.633040472100799	0.687522275449342	0.716568852377841	NA	NA	0.657465686178631	0.694682784682254	NA	NA	p.Leu174Val	1	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.537	-2.408	0.871	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174W	174	L	W	missense	wt-like	0.971307834283829	0.0915052840446283	6	0.0373568757796297	0.898089703180818	1.04452596538684	1.06120441730696	1.05433737860125	0.831129638980746	0.893254996363273	NA	NA	0.986139002892635	1.00178157155811	0.688783695408133	0.699315649336245	0.685287764463182	0.667207671810918	0.688981875038846	NA	NA	0.688585515777419	0.696960510659618	NA	NA	p.Leu174Trp	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.537	-5.682	4.145	0.006775284	NA	NA	NA	NA	NA	NA	NA
L174X	174	L	X	nonsense	low	-0.102067133040437	0.0507741822219401	6	0.0207284730918077	-0.142694193754888	-0.0614400723259865	-0.140278335045716	-0.0387602851632062	-0.112062833510013	-0.0701378153781741	NA	NA	-0.074606457765254	-0.17655707138026	0.43767585509182	0.443401301083254	0.448947184282362	0.384990333372944	0.369902445029463	NA	NA	0.470384791854428	0.431950409100387	NA	NA	p.Leu174Ter	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L174Y	174	L	Y	missense	possibly_wt-like	0.731372528219325	0.205086157444644	6	0.0837260731745785	0.567272440230186	0.895472616208464	0.488394492643661	0.89724291281917	0.953613006679412	0.627306902180074	NA	NA	0.533798526300982	0.887879328692654	0.626110464192094	0.577307840022288	0.651322092028872	0.703856533038101	0.600898836355316	NA	NA	0.595536784377943	0.671343727971132	NA	NA	p.Leu174Tyr	0	25.6	29	11.4	0.659	64.2	-134.2	-94.4	138.3	6.282722513089	-1.7	0	1	22.26	0	0	0	0	7	19.3578914894509	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.537	-4.566	3.029	0.006775284	NA	NA	NA	NA	NA	NA	NA
G175A	175	G	A	missense	wt-like	1.05772179968276	0.150438934612159	6	0.0614164378746186	0.937347793389769	1.17809580597576	0.917020398598565	0.912379977476407	1.16396181117806	1.27554643215268	NA	NA	1.11865141370883	0.958770764982037	0.701565653913172	0.668604630718622	0.654594903564307	0.766796051196522	0.815598279004594	NA	NA	0.715843991105649	0.687287316720696	NA	NA	p.Gly175Ala	1	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-2.433	-2.424	-0.009	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175C	175	G	C	missense	possibly_low	0.557972371454313	0.387290753917114	5	0.173201690563162	0.218503295889065	0.897441447019561	0.830716501457109	0.999309027163051	0.50560487208852	NA	NA	NA	-0.00648062924851003	0.460712085811394	0.575273183991984	0.650222006793808	0.67338998722294	0.569805777725227	NA	NA	NA	0.48439862047924	0.575273183991984	NA	NA	p.Gly175Cys	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-2.433	-4.435	2.002	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175D	175	G	D	missense	wt-like	1.20945447004384	0.110285251581519	6	0.0450237654215322	1.12120951136925	1.29769942871842	1.09413285097008	1.2658862390953	1.31068321113454	1.09305138292634	NA	NA	1.34080219221526	1.15217094392149	0.74309116496145	0.706329365199738	0.731027117938306	0.810697295317211	0.755155211984594	NA	NA	0.761541533530291	0.730783302674708	NA	NA	p.Gly175Asp	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-2.433	-2.835	0.402	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175E	175	G	E	missense	possibly_low	0.646021054810505	0.345173032887974	6	0.140916300590742	0.36983018081803	0.92221192880298	0.988398412431721	1.03122484964418	0.843884463767958	0.394490829211462	NA	NA	0.291453583130818	0.326674190676894	0.608354653277792	0.683808059859769	0.680290563678442	0.67102410674724	0.523789251402564	NA	NA	0.545685199808343	0.545127863361744	NA	NA	p.Gly175Glu	1	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-2.433	-2.807	0.374	0.008163614	1.095846645	0.0145296632697071	NA	NA	5.78e-05	NA	NA
G175F	175	G	F	missense	wt-like	0.887659681283001	0.153925408270462	6	0.0628397847853683	0.764495966307431	1.01082339625857	1.07845867632151	0.947006739651034	0.833250271107514	1.00153380793693	NA	NA	0.647175501822059	0.818533090858953	0.664961906923543	0.702990785281102	0.662081617088103	0.667842196758983	0.724844236744207	NA	NA	0.618859003564773	0.655747656636975	NA	NA	p.Gly175Phe	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-2.433	-4.819	2.386	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175G	175	G	G	synonymous	wt-like	1.03243284646425	0.0539875727704362	6	0.022040334289824	0.989234585048976	1.07563110787953	1.07315981386809	1.04989823064484	1.10918601297202	0.969351408573524	NA	NA	1.0053615389178	0.987640073809257	0.697821100510763	0.701862134096892	0.684327968428201	0.750406310574758	0.714185301447971	NA	NA	0.692539688980975	0.693780066924634	NA	NA	p.Gly175=	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175H	175	G	H	missense	wt-like	1.07298735163971	0.275789361841117	6	0.112590535499756	0.852313957060111	1.29366074621931	0.855696988496463	0.962094369522895	1.13094636916221	0.909841939178982	NA	NA	0.975899879150284	1.60344456432743	0.690477405399374	0.655542819803567	0.665343740241115	0.756917335616381	0.694475534732722	NA	NA	0.686479276066026	0.832275406571565	NA	NA	p.Gly175His	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-2.433	-3.478	1.045	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175I	175	G	I	missense	possibly_low	0.625070298692501	0.152632817167661	6	0.0623120866773808	0.502940853003296	0.747199744381705	0.839552080704164	0.789716132914791	0.594692955281371	0.473223070287456	NA	NA	0.524691262083675	0.528546290883549	0.595062821357446	0.652103974304386	0.628073536671011	0.596462268800513	0.549865674539331	NA	NA	0.593663373914379	0.590529196924339	NA	NA	p.Gly175Ile	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-2.433	-4.457	2.024	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175K	175	G	K	missense	wt-like	1.12396005240419	0.227509794400912	6	0.0928804846279574	0.941917647666766	1.30600245714161	0.787947535653754	1.06480466214718	1.32116013102075	1.40794576555485	NA	NA	0.983062227604068	1.17883999244453	0.712366909286753	0.641112269689728	0.687550914361098	0.813832146931861	0.859449450946828	NA	NA	0.687952607487718	0.736781211085787	NA	NA	p.Gly175Lys	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-2.433	-2.402	-0.031	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175L	175	G	L	missense	possibly_wt-like	0.810679637345077	0.137035783801976	6	0.0559446244695322	0.701030188256176	0.920329086433978	0.928603429607428	0.87736578281184	0.855302798474262	0.897069354145904	NA	NA	0.743083740576462	0.562652718454567	0.659048112325489	0.671071802074701	0.647024422576278	0.674440643800062	0.69024520510764	NA	NA	0.638587814955029	0.598199782870565	NA	NA	p.Gly175Leu	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-2.433	-3.284	0.851	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175M	175	G	M	missense	possibly_wt-like	0.833742296357284	0.384107349572195	6	0.156811168817454	0.526398053101444	1.14108653961312	1.38381616962959	1.12597390371592	0.761532458556781	0.853700245351293	NA	NA	0.312210990248616	0.565220010641496	0.661132169796055	0.768031555721697	0.700776424323119	0.646383151265106	0.675881188327003	NA	NA	0.549955103784231	0.598777170676072	NA	NA	p.Gly175Met	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-2.433	-5.194	2.761	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175N	175	G	N	missense	wt-like	0.9389557512745	0.192597655730609	6	0.0786276636993687	0.78484836223521	1.09306314031379	0.592078653393481	1.15262260343397	1.01876552925156	1.04475716737603	NA	NA	0.896088390548998	0.92942216364296	0.693612479884163	0.599392438715437	0.706538186845544	0.723351145271673	0.739159980773879	NA	NA	0.670061647863902	0.680686772922781	NA	NA	p.Gly175Asn	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-2.433	-2.547	0.114	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175P	175	G	P	missense	wt-like	0.960345944366271	0.10806287082237	6	0.0441164822758498	0.873879227981006	1.04681266075154	1.12012521452406	1.04843343406107	0.919399393749701	0.870895715378218	NA	NA	0.966885519104257	0.836336389380328	0.684318119314356	0.711865706662356	0.684011262166784	0.693619306744435	0.68157639458977	NA	NA	0.684624976461929	0.659751644775286	NA	NA	p.Gly175Pro	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-2.433	-2.175	-0.258	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175Q	175	G	Q	missense	wt-like	1.07482575978249	0.160117742992839	6	0.0653677948497588	0.946707236128157	1.20294428343682	0.997484845133485	0.951348193845786	0.97419497890599	1.21414829913146	NA	NA	1.3351658213542	0.976612420324005	0.7006574496416	0.685743458847614	0.663020290582	0.710014967918577	0.795262979582295	NA	NA	0.760382103442869	0.691299931364623	NA	NA	p.Gly175Gln	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-2.433	-3.087	0.654	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175R	175	G	R	missense	possibly_wt-like	0.787347268764601	0.155330834201894	6	0.0634135475192488	0.663058999494954	0.911635538034248	0.92756868972995	0.944136771229694	0.676078992074388	0.907042246071625	NA	NA	0.595642836273083	0.673614077208864	0.642308126257515	0.670851403753678	0.661461096137153	0.620814192039559	0.69354826553369	NA	NA	0.608258472763073	0.623155156377878	NA	NA	p.Gly175Arg	1	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-2.433	-2.736	0.303	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175S	175	G	S	missense	possibly_wt-like	0.744478543791172	0.116405606942099	6	0.0475223900345205	0.651336370864247	0.837620716718097	0.855183983818424	0.878754934019336	0.648040644373556	0.582667319319425	NA	NA	0.781888251630846	0.720336129585443	0.640116557384592	0.655433550438215	0.647324773417033	0.612424697749564	0.586114033644067	NA	NA	0.646570099789218	0.633663014979966	NA	NA	p.Gly175Ser	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-2.433	-2.486	0.053	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175T	175	G	T	missense	wt-like	1.25393735243494	0.234488015478285	2	0.165808065851671	0.928959515019421	1.57891518985046	1.08812928658327	1.41974541828661	NA	NA	NA	NA	NA	NA	0.734671948352203	0.705050613370603	0.764293283333803	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly175Thr	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-2.433	-3.014	0.581	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175V	175	G	V	missense	wt-like	0.990212955410206	0.0481429276231051	6	0.0196542679000582	0.95169129818359	1.02873461263682	0.982198605678072	1.00858914688068	0.992897444531324	1.06967341777864	NA	NA	0.926829640119718	0.96108947747281	0.685148153616607	0.682487508647904	0.675396458328786	0.715611026225818	0.747412339395971	NA	NA	0.676385278894543	0.68780879858531	NA	NA	p.Gly175Val	1	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-2.433	-3.441	1.008	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175W	175	G	W	missense	wt-like	0.894597913914316	0.102392505891595	6	0.0418015654865545	0.812668351063276	0.976527476765355	0.944735595651432	0.993975340409044	0.713592039096617	0.945462446812493	NA	NA	0.837511307915707	0.9323107536006	0.673372357484382	0.674507933597168	0.672236781371595	0.632038658514948	0.706273184802169	NA	NA	0.658012044721642	0.681336421071575	NA	NA	p.Gly175Trp	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-2.433	-5.937	3.504	0.008163614	NA	NA	NA	NA	NA	NA	NA
G175X	175	G	X	nonsense	possibly_low	0.579377277100186	0.186474939013413	6	0.0761280750665791	0.43016899175733	0.728585562443043	0.597437769888423	0.674129119489071	0.854339313496644	0.610849393799612	NA	NA	0.363351033237524	0.376157032689843	0.597990984892	0.600533923936369	0.603082263960461	0.674152354639642	0.59544804584763	NA	NA	0.560474870132994	0.556256627631573	NA	NA	p.Gly175Ter	1	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G175Y	175	G	Y	missense	wt-like	1.29491041622663	0.314227724871314	6	0.128282931495063	1.04348049066509	1.54634034178817	0.919604306207348	0.951025440474032	1.36412461748518	1.26959348429498	NA	NA	1.65644603161526	1.60866861728298	0.820048856312394	0.669154999860711	0.662950507504362	0.826687765876024	0.813626639621195	NA	NA	0.826471073003593	0.833450303798772	NA	NA	p.Gly175Tyr	0	25.8	32.6	12.5	0.184	41.9	-92.2	-68.2	173.3	9.27835051546392	-2.7	0	1	26.19	0	0	0	0	8	22.7522582137784	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-2.433	-4.108	1.675	0.008163614	NA	NA	NA	NA	NA	NA	NA
K176A	176	K	A	missense	wt-like	1.00440554726488	0.0825824505364694	6	0.0337141442538302	0.938327038757789	1.07048405577198	0.88316863219097	1.00224137214523	1.01913175046426	1.13972631513023	NA	NA	0.975072302453414	1.0070929112052	0.692232039066357	0.661394246116389	0.674023994720488	0.723460724152911	0.770614130280261	NA	NA	0.68630903934001	0.698155038792703	NA	NA	p.Lys176Ala	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.372	-2.304	-0.068	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176C	176	K	C	missense	wt-like	0.924961172363266	0.213338154562898	6	0.0870949368910185	0.754258232821081	1.09566411190545	0.876724303895126	1.05238251895614	0.860260219764441	1.28936156048884	NA	NA	0.746754867925483	0.724283563149567	0.667972795371428	0.660021612116833	0.684865100800078	0.675923978626023	0.820173903008927	NA	NA	0.639342984479557	0.63455079862009	NA	NA	p.Lys176Cys	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.372	-3.995	1.623	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176D	176	K	D	missense	wt-like	1.2510393882567	0.205706557199431	6	0.0839793503138747	1.08644288619643	1.41563589031696	1.04910351633603	0.932283373589662	1.36273805980651	1.36546820618287	NA	NA	1.40922584053709	1.38741733308801	0.779653594164282	0.696738172315301	0.658898252058142	0.826272887016113	0.84538071878751	NA	NA	0.77561662520027	0.783690563128293	NA	NA	p.Lys176Asp	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.372	-2.735	0.363	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176E	176	K	E	missense	possibly_low	0.579261195857986	0.128595228047298	2	0.0909305577804751	0.401040577514116	0.757481814201855	0.670191753638461	NA	NA	NA	NA	NA	0.48833063807751	NA	0.601107121012241	0.616030432977169	NA	NA	NA	NA	NA	0.586183809047313	NA	NA	NA	p.Lys176Glu	1	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.372	-2.705	0.333	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176F	176	K	F	missense	possibly_wt-like	0.839273351914965	0.156670456213943	6	0.0639604459155358	0.713913181485393	0.964633522344537	0.855719626460743	1.07964953310957	0.709688991487357	0.660056262957868	NA	NA	0.780365288443967	0.950160409030282	0.650902230097818	0.655547641662111	0.690760550180719	0.630870808113033	0.611745551467567	NA	NA	0.646256818533526	0.685350834947048	NA	NA	p.Lys176Phe	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.372	-4.874	2.502	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176G	176	K	G	missense	wt-like	1.07993089129132	0.137147527948948	6	0.0559902438265028	0.970192029905761	1.18966975267688	0.84040080349431	1.01700985901265	1.09527050265486	1.11854156346191	NA	NA	1.2116339026109	1.1967287165133	0.737887686230356	0.652284751214635	0.677217115399768	0.746242581114169	0.763597658489279	NA	NA	0.734970960904804	0.740804411555907	NA	NA	p.Lys176Gly	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.372	-2.83	0.458	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176H	176	K	H	missense	possibly_wt-like	0.80651491508944	0.19391856304491	6	0.0791669218522935	0.651350599492047	0.961679230686832	1.16867186941173	0.88473163689799	0.724486019398027	0.670850618373264	NA	NA	0.674930040790022	0.715419305665605	0.633927757439861	0.722206084434	0.648617006922541	0.635298300862963	0.615320683782533	NA	NA	0.62456825306861	0.632557214016759	NA	NA	p.Lys176His	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.372	-3.564	1.192	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176I	176	K	I	missense	possibly_wt-like	0.901527704724797	0.301495344839871	6	0.12308495911369	0.660285617823379	1.14276979162621	0.844962744503472	1.18003994948009	1.09825585251694	1.18209924753588	NA	NA	0.628823098806648	0.474985335505751	0.682861289394231	0.653256439037737	0.712466139750724	0.747135842581955	0.784648209583159	NA	NA	0.615083821136742	0.57848325893415	NA	NA	p.Lys176Ile	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.372	-4.461	2.089	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176L	176	K	L	missense	wt-like	1.17137755290718	0.0476773160081139	6	0.0194641827542179	1.1332284557204	1.20952665009395	1.14428150049799	1.24460561155088	1.20106099529216	1.10838461793906	NA	NA	1.1519727853182	1.17795980684476	0.731504625921874	0.717010965859068	0.72642599579965	0.777896683680636	0.760233638799109	NA	NA	0.722698366332259	0.736583256044098	NA	NA	p.Lys176Leu	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.372	-3.688	1.316	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176M	176	K	M	missense	possibly_wt-like	0.847715796868873	0.261460635697235	6	0.106740857546991	0.63850756039785	1.0569240333399	1.19043798696444	1.0655470210774	0.573999585408884	0.604319269715658	NA	NA	0.970552365246247	0.681438552800606	0.655147078909011	0.726842240697244	0.687711421099049	0.590270502073089	0.593285243462971	NA	NA	0.685379265320446	0.624914892497576	NA	NA	p.Lys176Met	1	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.372	-4.137	1.765	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176N	176	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys176Asn	1	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.372	-2.858	0.486	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176P	176	K	P	missense	possibly_wt-like	0.88401582893408	0.369358310741072	6	0.150789898928663	0.588473057801467	1.17955860006669	0.303620786633795	0.720141401548831	1.07371751915657	1.37769314691998	NA	NA	0.778709953280424	1.05021216606488	0.676884465300672	0.537951267940657	0.613030660885944	0.739793605093165	0.849429666501002	NA	NA	0.645916307690523	0.70785262291082	NA	NA	p.Lys176Pro	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.372	-2.19	-0.182	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176Q	176	K	Q	missense	wt-like	1.0779677235892	0.124536315810767	6	0.0508417380304133	0.978319748138171	1.17761569904023	0.844475048827536	1.06744620725245	1.07376049595967	1.17266625460554	NA	NA	1.18749185383195	1.12196648105807	0.726997546659867	0.6531525604587	0.688122047502672	0.73980646439743	0.781523965795147	NA	NA	0.730004818964131	0.723990274355604	NA	NA	p.Lys176Gln	1	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.372	-2.773	0.401	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176R	176	K	R	missense	wt-like	0.932341926976066	0.0976093098300255	6	0.0398488338714654	0.854239647762074	1.01044420619006	0.811542485550484	0.932658889076375	1.10143561412247	0.904559074007823	NA	NA	0.96354390734323	0.880311591756015	0.676789661360099	0.646137964992519	0.658979442926021	0.748087274960132	0.692725829330019	NA	NA	0.683937589965952	0.669641732754246	NA	NA	p.Lys176Arg	1	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.372	-2.812	0.44	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176S	176	K	S	missense	wt-like	0.870467494177299	0.12727825023882	6	0.0519611280732302	0.768625554557695	0.972309433796904	0.646389275127466	0.950390932004556	0.920798798754333	0.866952545558548	NA	NA	1.01164881723809	0.826624596380808	0.67154186039043	0.61096053433483	0.662813319305378	0.694038029717023	0.680270401475481	NA	NA	0.693833014035735	0.65756744818244	NA	NA	p.Lys176Ser	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.372	-2.56	0.188	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176T	176	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys176Thr	1	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.372	-2.669	0.297	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176V	176	K	V	missense	wt-like	1.15434143646391	0.176915879171947	6	0.0722256052278587	1.0127818514557	1.29590102147212	0.943059152603734	0.976462903919517	1.07846822162212	1.32547481037016	NA	NA	1.33277978758022	1.26980374268773	0.749227089720923	0.674150853290277	0.668450386488945	0.741215086545404	0.832134751219004	NA	NA	0.759891284187829	0.757239092896442	NA	NA	p.Lys176Val	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.372	-3.254	0.882	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176W	176	K	W	missense	possibly_wt-like	0.786567971505517	0.103607607097465	6	0.0422976284765918	0.703666143059941	0.869469799951093	0.902317792652928	0.876354025599714	0.729352437869163	0.832692223558888	NA	NA	0.752225364237065	0.626465985115344	0.643636981044758	0.66547299373854	0.646805668759083	0.636754406280156	0.668923250155316	NA	NA	0.640468293330433	0.61255148081406	NA	NA	p.Lys176Trp	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.372	-5.983	3.611	0.008384427	NA	NA	NA	NA	NA	NA	NA
K176X	176	K	X	nonsense	low	0.253560684922514	0.30397315122316	6	0.124096519333769	0.0103359764215488	0.496785393423478	0.0236145684677755	-0.241931395402623	0.328224846043157	0.430314726637524	NA	NA	0.405580801210911	0.575560562578338	0.526192638833936	0.478310287919574	0.405019199014696	0.516731012708937	0.535654264958934	NA	NA	0.569161747696607	0.601102776082789	NA	NA	p.Lys176Ter	1	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K176Y	176	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys176Tyr	0	28.8	34.8	11.7	0.845	120.2	35.2	-59.1	-39	73.9130434782609	-0.6	0	1	27.52	0	0	0	0	3	25.8036716768809	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.372	-4.816	2.444	0.008384427	NA	NA	NA	NA	NA	NA	NA
K177A	177	K	A	missense	wt-like	0.97367799989619	0.106993574155635	6	0.0436799437396564	0.888066883319727	1.05928911647265	0.773590563792576	0.974825507591356	0.962867573276344	1.06752328466218	NA	NA	1.05956823571826	1.00369283433642	0.700540319031115	0.638054252344456	0.668096362131367	0.706625638209696	0.746700206981362	NA	NA	0.703690281580258	0.697390356481973	NA	NA	p.Lys177Ala	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.781	-2.193	-0.588	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177C	177	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys177Cys	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.781	-3.953	1.172	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177D	177	K	D	missense	wt-like	1.07775081843548	0.270267396297352	6	0.110336202506513	0.861495835331791	1.29400580153916	0.583686493264406	1.12567395202288	0.964877641685702	1.26624836933655	NA	NA	1.29393742336301	1.2320810309403	0.727991140065662	0.597604918931518	0.700711571236785	0.70722708083473	0.812518724592932	NA	NA	0.751901212765965	0.748755199296595	NA	NA	p.Lys177Asp	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.781	-2.636	-0.145	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177E	177	K	E	missense	possibly_wt-like	0.844615212370706	0.346121743246481	6	0.141303609972748	0.567665225938625	1.12156519880279	1.31792851167955	1.13331119557694	0.81165384721541	0.868935149390901	NA	NA	0.412384085513389	0.523478484848045	0.671153635131425	0.753997565629718	0.702362833180144	0.661380222720416	0.680927047542434	NA	NA	0.570561217800334	0.589389439860273	NA	NA	p.Lys177Glu	1	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.781	-2.758	-0.023	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177F	177	K	F	missense	possibly_wt-like	0.935307674393667	0.342412047373237	6	0.139789132974355	0.66132600833385	1.20928934045348	0.416074778375777	0.605737755238943	1.03250248831253	1.25037736196675	NA	NA	1.19836706162624	1.10878660084175	0.724243774670951	0.561903829846972	0.588295246073543	0.727461449517615	0.807262185491216	NA	NA	0.732241904392765	0.721026099824286	NA	NA	p.Lys177Phe	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.781	-4.783	2.002	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177G	177	K	G	missense	wt-like	1.09696847239538	0.134929809492469	6	0.0550848640579152	0.989004122748585	1.20493282204218	0.942812134278494	0.95958773524698	1.22251788700056	1.20881437552476	NA	NA	1.22061780998707	1.02746089233443	0.719777412039257	0.674098238690869	0.664801776408688	0.784316907596446	0.793496363428016	NA	NA	0.736818996240182	0.702735827838333	NA	NA	p.Lys177Gly	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.781	-1.995	-0.786	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177H	177	K	H	missense	possibly_wt-like	0.812378222912684	0.265336712750573	6	0.108323259377723	0.600068535844357	1.02468790998101	0.586838274921962	1.08405544836804	1.03115425058141	1.04635312210237	NA	NA	0.550910212153139	0.574958029349173	0.646340213192348	0.598276244547429	0.69171316091527	0.727058036560922	0.739688567159616	NA	NA	0.599056744989575	0.600967265469426	NA	NA	p.Lys177His	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.781	-3.13	0.349	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177I	177	K	I	missense	possibly_wt-like	0.742784778690815	0.296488316496729	5	0.132593606044232	0.482906086263829	1.0026634711178	0.971214855334805	0.955327796708209	0.9441874125099	0.360850952967259	NA	NA	0.482342875933903	NA	0.663880727559017	0.680147983336395	0.663880727559017	0.701036253850873	0.512647594119297	NA	NA	0.584952095989966	NA	NA	NA	p.Lys177Ile	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.781	-3.764	0.983	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177L	177	K	L	missense	low	0.311145899121168	0.176700311443032	6	0.0721376000710499	0.169758801050756	0.452532997191579	0.535418303123573	0.454436601797832	0.325489963617707	0.226908117289963	NA	NA	0.0325433831309021	0.292079025767027	0.526630027260969	0.587323853808399	0.555582155952069	0.51591269485594	0.468285208246293	NA	NA	0.492426057849829	0.537347359665998	NA	NA	p.Lys177Leu	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.781	-3.661	0.88	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177M	177	K	M	missense	possibly_low	0.720585582758898	0.240915137331391	6	0.0983531929624073	0.527816866788062	0.913354298729735	0.735619729044404	0.829201491198255	0.952009770309778	0.938542799389449	NA	NA	0.353658266630336	0.514481439981166	0.633288623554896	0.629966511252732	0.63661073585706	0.703376820663033	0.703981370779164	NA	NA	0.558481018856748	0.587365991178357	NA	NA	p.Lys177Met	1	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.781	-4.365	1.584	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177N	177	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys177Asn	1	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.781	-2.673	-0.108	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177P	177	K	P	missense	wt-like	1.68811937561829	0.126775390023693	2	0.0896437379733228	1.51242087775103	1.86381787348555	1.77776311359161	1.59847563764497	NA	NA	NA	NA	NA	NA	0.827439315254117	0.851941770173702	0.802936860334532	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys177Pro	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.781	-3.313	0.532	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177Q	177	K	Q	missense	wt-like	1.36262902936055	0.355107978856809	6	0.14497222529837	1.07848868901712	1.64676936970398	0.969659188224184	0.96115478360867	1.53886906704801	1.24923665569573	NA	NA	1.76945450568977	1.68739997589694	0.828300934364888	0.679816628155529	0.66514059070795	0.878973926867323	0.806884379156843	NA	NA	0.849717489572933	0.851157102661069	NA	NA	p.Lys177Gln	1	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.781	-3.212	0.431	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177R	177	K	R	missense	wt-like	0.972894882627112	0.184142642620454	6	0.0751759190512983	0.825552788781869	1.12023697647236	0.721831703575896	1.07619728600135	1.06138783774577	1.23324290389505	NA	NA	0.870148099744891	0.874561464799722	0.679181327215801	0.627029678789211	0.690014133724502	0.736104379433469	0.801587186624288	NA	NA	0.664725598413623	0.6683485207071	NA	NA	p.Lys177Arg	1	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.781	-3.104	0.323	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177S	177	K	S	missense	possibly_low	0.529120904920899	0.304096566555125	6	0.12414690343206	0.285797445401889	0.772444364439908	0.541472901339501	0.558136229703355	0.429266387123145	0.897262716968945	NA	NA	0.740310563419138	0.00827663097130879	0.583308355892126	0.588613475780357	0.578003236003895	0.546964157721176	0.690309247623434	NA	NA	0.638017358341508	0.473519781814509	NA	NA	p.Lys177Ser	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.781	-2.522	-0.259	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177T	177	K	T	missense	wt-like	1.00990545124878	0.117943271254359	6	0.0481501388613079	0.915532913230011	1.10427798926754	1.05394426370682	1.0851577897978	1.17109284528611	0.851796930069487	NA	NA	0.99045683155767	0.906984047074774	0.690712607575369	0.697769245550458	0.691951500106454	0.768929763588192	0.675250802935037	NA	NA	0.689473715044284	0.675640407358715	NA	NA	p.Lys177Thr	1	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.781	-2.704	-0.077	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177V	177	K	V	missense	low	0.621677801407714	0.0887075315191745	6	0.0362146980939722	0.550698297432537	0.692657305382891	0.641837137766914	0.724171226436897	0.644276897192355	0.67619934459997	NA	NA	0.571770127703032	0.471812074747116	0.610644731401231	0.609990934676822	0.613901956455997	0.611298528125641	0.617092202621882	NA	NA	0.603347735470116	0.577769587901667	NA	NA	p.Lys177Val	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.781	-3.093	0.312	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177W	177	K	W	missense	possibly_low	0.517770177121311	0.444898223338366	6	0.181628939108298	0.161783997918829	0.873756356323793	0.867818892699447	0.962274272169711	0.770052606625824	0.561436458882576	NA	NA	-0.0960524396812826	0.0410912720315899	0.614007398922552	0.658124770487101	0.665382637310731	0.648932507394713	0.579082290450392	NA	NA	0.465973244548428	0.480899843066111	NA	NA	p.Lys177Trp	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.781	-5.91	3.129	0.008277255	NA	NA	NA	NA	NA	NA	NA
K177X	177	K	X	nonsense	low	0.0334501242699599	0.216816310938078	6	0.0885148882851518	-0.140035868864524	0.206936117404444	0.286988348215972	0.328241957541417	-0.0903890511066127	-0.0329909695247052	NA	NA	-0.143092652090193	-0.148056887416119	0.447328488365766	0.534408579017973	0.52829738860881	0.391475454238697	0.382205624228139	NA	NA	0.456296834154223	0.43836014257731	NA	NA	p.Lys177Ter	1	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K177Y	177	K	Y	missense	possibly_wt-like	0.90217318301036	0.337937125349235	6	0.137962253708097	0.631772134516511	1.17257423150421	1.11532964530245	1.27569795264916	0.857374339369918	1.15395467658965	NA	NA	0.558722123030764	0.451960361120221	0.692952368116332	0.710844256317399	0.733148525888169	0.675060479915265	0.775326618695274	NA	NA	0.600663694698003	0.573304908179996	NA	NA	p.Lys177Tyr	0	30.3	33.8	15	0.97	84.4	151.6	-116.7	135.2	67.3913043478261	-0.6	0	1	22.57	0	0	0	0	5	25.3579788269902	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.781	-4.124	1.343	0.008277255	NA	NA	NA	NA	NA	NA	NA
F178A	178	F	A	missense	possibly_wt-like	0.947469396982005	0.33196103178073	6	0.135522523725103	0.681850131386829	1.21308866257718	1.26646469977878	1.11655794698081	1.13611047697247	1.10119034907195	NA	NA	0.441125874726945	0.623367034361085	0.72088821032908	0.74303583700281	0.69874058365535	0.758462514150058	0.75785086909035	NA	NA	0.576473549689409	0.61185452221134	NA	NA	p.Phe178Ala	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-3.032	-2.346	-0.686	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178C	178	F	C	missense	wt-like	0.965666211087768	0.161308960958554	6	0.0658541075478318	0.83659453205999	1.09473789011555	0.684526216527257	0.883526413831581	1.05348438191777	1.02563426181019	NA	NA	1.00345113537817	1.14337485706163	0.710475879512068	0.619083655939013	0.648356423510642	0.733739546874587	0.732826400396587	NA	NA	0.692146709278688	0.728805049745447	NA	NA	p.Phe178Cys	1	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-3.032	-2.401	-0.631	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178D	178	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178Asp	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-3.032	-3.802	0.77	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178E	178	F	E	missense	low	0.188008549333812	0.351719458952653	6	0.143588867840295	-0.0934204602140487	0.469437558881673	-0.31907711835299	-0.182028937025015	0.282683626645501	0.370613904147442	NA	NA	0.4543476087451	0.521512211842833	0.509492758984991	0.405317380187253	0.417970815541316	0.503104396612558	0.515881121357424	NA	NA	0.579193327469547	0.588947222156621	NA	NA	p.Phe178Glu	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-3.032	-3.606	0.574	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178G	178	F	G	missense	wt-like	0.933615220201477	0.0744347584088413	6	0.0303878628715001	0.874056103406195	0.993174336996759	0.909713660090592	1.01224557689478	0.856787749626534	0.993411052838749	NA	NA	0.988115495699032	0.841417786059172	0.675535992497932	0.667048304404772	0.676187021532396	0.674884963463468	0.722153948800134	NA	NA	0.688992090377246	0.660894458395118	NA	NA	p.Phe178Gly	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-3.032	-2.275	-0.757	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178H	178	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178His	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-3.032	-4.338	1.306	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178I	178	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178Ile	1	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-3.032	-3.531	0.499	0.007669125	NA	NA	NA	NA	4.06e-06	NA	NA
F178K	178	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178Lys	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-3.032	-3.359	0.327	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178L	178	F	L	missense	low	0.545328551899628	0.111022551966813	6	0.0453247670433869	0.456493640886922	0.634163462912334	0.398937368895933	0.568398818756206	0.663810062973722	0.647248962701394	NA	NA	0.424229727282993	0.569346370787519	0.58996366185602	0.558253582709265	0.580222128543245	0.61714314438252	0.60750372402606	NA	NA	0.572997926422077	0.599705195168794	NA	NA	p.Phe178Leu	1	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-3.032	-3.308	0.276	0.007669125	NA	NA	NA	NA	4.06e-06	NA	NA
F178M	178	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178Met	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-3.032	-3.875	0.843	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178N	178	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178Asn	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-3.032	-3.562	0.53	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178P	178	F	P	missense	low	0.17248071172399	0.35741869542444	6	0.145915571386852	-0.113508552977823	0.458469976425803	0.676318591600516	0.52078082323288	0.0863914659987341	0.0574051196495148	NA	NA	-0.277581683054296	-0.0284300470834103	0.454817616439438	0.617335441926187	0.569926557468403	0.444370837185733	0.412145159023556	NA	NA	0.428631758031372	0.465264395693143	NA	NA	p.Phe178Pro	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-3.032	-2.498	-0.534	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178Q	178	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178Gln	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-3.032	-3.539	0.507	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178R	178	F	R	missense	low	0.0933968347905721	0.0951482262124239	6	0.038844100691891	0.0172637964226184	0.169529873158526	0.216168487603201	0.107654392448618	-0.0297164202524312	0.0571537912227894	NA	NA	0.0231046029285675	0.186016154792688	0.485544106841892	0.519324035826158	0.48060376081789	0.409629615658666	0.412061918075349	NA	NA	0.490484452865894	0.513493663296945	NA	NA	p.Phe178Arg	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-3.032	-3.626	0.594	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178S	178	F	S	missense	wt-like	0.868607076804349	0.162541965011449	6	0.0663574793445612	0.738548807184149	0.99866534642455	0.65091077460511	1.13895242049164	0.800152775288324	0.83170403788397	NA	NA	0.849221423930488	0.940701028626564	0.664508417120458	0.611923608161468	0.703582532401418	0.657938929449834	0.668595959233011	NA	NA	0.660420875007904	0.683223406319887	NA	NA	p.Phe178Ser	1	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-3.032	-2.535	-0.497	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178T	178	F	T	missense	possibly_low	0.463165984694506	0.443156628463035	6	0.180917935977764	0.108573346020766	0.817758623368246	0.509913226111248	1.29328810406034	0.443185453184677	0.00411546246962303	NA	NA	0.278151618860895	0.250342043480257	0.547038934686061	0.581891303779719	0.73695172365155	0.551128951113827	0.394495418200164	NA	NA	0.542948918258295	0.527960650691563	NA	NA	p.Phe178Thr	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-3.032	-2.444	-0.588	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178V	178	F	V	missense	low	0.313965389917776	0.281916620558538	6	0.115091978396373	0.0883892573514237	0.539541522484128	0.303166371901615	0.478652760826084	0.488886395738871	0.65386484814408	NA	NA	-0.0056986321958402	-0.0350794049081543	0.549336226354566	0.537854478161699	0.560817974547434	0.564803358774961	0.609694930904845	NA	NA	0.484559481241154	0.463768945295246	NA	NA	p.Phe178Val	1	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-3.032	-2.864	-0.168	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178W	178	F	W	missense	wt-like	1.15197291776934	0.0823017250959928	6	0.0335995385726659	1.08611903226975	1.21782680326893	1.10762324628811	1.1747562508977	1.11254693873377	1.29584377384703	NA	NA	1.16389205451447	1.05717524233497	0.718236981209852	0.709202802807334	0.711323741930422	0.751411949986472	0.822320837175681	NA	NA	0.725150220489282	0.709418629050532	NA	NA	p.Phe178Trp	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-3.032	-3.97	0.938	0.007669125	NA	NA	NA	NA	NA	NA	NA
F178X	178	F	X	nonsense	low	0.272941453315099	0.366106459507047	6	0.14946233622153	-0.0199993427243158	0.565882249354513	0.098309600274198	-0.0122591844371633	0.594959857854299	0.786638064361157	NA	NA	0.330061523353314	-0.160061141515213	0.523923643416772	0.494220237808614	0.45467703416554	0.59654213005466	0.653669934283246	NA	NA	0.55362704902493	0.435660368096511	NA	NA	p.Phe178Ter	0	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F178Y	178	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe178Tyr	1	29.7	30.3	16.3	0.985	42.5	-135.8	-157.2	159.2	6.14035087719298	-1.6	0	1	16.68	0	0	0	0	7	22.0357061319926	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-3.032	-3.244	0.212	0.007669125	NA	NA	NA	NA	NA	NA	NA
Q179A	179	Q	A	missense	wt-like	1.03630197007457	0.116565718028219	6	0.047587755111713	0.943031683950505	1.12957225619864	0.868375687924098	1.07128594149534	1.19038754045764	1.12660006679709	NA	NA	0.966280568539778	0.994882015233486	0.692180516743718	0.658243367185013	0.688952243237957	0.774703025860847	0.766266666000629	NA	NA	0.684500535061044	0.69540879024948	NA	NA	p.Gln179Ala	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.142	-2.977	0.835	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179C	179	Q	C	missense	low	0.00969546927827337	0.0392660319229722	2	0.0277652774430211	-0.0447234745308103	0.064114413087357	NA	NA	NA	NA	NA	NA	0.0374607467212945	-0.0180698081647477	0.480516006612142	NA	NA	NA	NA	NA	NA	0.49343758449313	0.467594428731155	NA	NA	p.Gln179Cys	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.142	-3.546	1.404	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179D	179	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Asp	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.142	-3.401	1.259	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179E	179	Q	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Glu	1	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.142	-2.786	0.644	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179F	179	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Phe	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.142	-4.771	2.629	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179G	179	Q	G	missense	possibly_wt-like	0.790311506631645	0.104888630429494	6	0.0428206040619369	0.706384664874	0.874238348389291	0.690147131809602	0.664122156281471	0.858080294110141	0.932662521842407	NA	NA	0.843502183241141	0.75335475250511	0.650166675114688	0.620280903979612	0.600918640737457	0.675271712164943	0.702033800084075	NA	NA	0.659244398176288	0.641088952053087	NA	NA	p.Gln179Gly	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.142	-2.958	0.816	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179H	179	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179His	1	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.142	-3.219	1.077	0.007530625	1.057507987	0.0348010218502802	0.94	0.26	NA	17.852	0.720399105
Q179I	179	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Ile	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.142	-3.43	1.288	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179K	179	Q	K	missense	wt-like	1.26201590280569	0.347699916652891	6	0.14194789656797	0.983803137851253	1.54022866776013	1.34962070000297	1.20835914327784	1.41083084126366	0.746954718966879	NA	NA	1.78262061279377	1.07370940052903	0.739668522755385	0.760747962756615	0.718589082754155	0.840662968761648	0.640526656614002	NA	NA	0.852425824614555	0.713137185654326	NA	NA	p.Gln179Lys	1	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.142	-2.375	0.233	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179L	179	Q	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Leu	1	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.142	-2.989	0.847	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179M	179	Q	M	missense	wt-like	0.974439296196309	0.227080456235408	6	0.0927052080558594	0.792740427227532	1.15613816516509	0.73300261217169	1.130873791411	1.21378088308007	1.1561685350957	NA	NA	0.687486374301697	0.925323581117697	0.690800416685152	0.629409068578277	0.7018358377123	0.781702664942609	0.776059857205694	NA	NA	0.627151154588044	0.679764995658004	NA	NA	p.Gln179Met	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.142	-5.062	2.92	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179N	179	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Asn	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.142	-3.333	1.191	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179P	179	Q	P	missense	low	-0.37511262937693	0.0441415508439291	3	0.02548513626219	-0.425062578591918	-0.325162680161941	-0.400933287428733	-0.32414383579666	-0.400260764905395	NA	NA	NA	NA	NA	0.387243901797525	0.387882116869085	0.387243901797525	0.298757188480524	NA	NA	NA	NA	NA	NA	NA	p.Gln179Pro	1	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.142	-2.92	0.778	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179R	179	Q	R	missense	wt-like	1.12968455110122	0.207941615740208	8	0.0735184632903942	0.985591010853314	1.27377809134912	1.03480593550522	0.992570462847131	1.0746342332233	1.23713665498035	1.56762309280506	1.21628191142099	0.929675703979455	0.984748414048222	0.703695821260318	0.693692805186437	0.671933030307923	0.740067899695346	0.802876812062379	0.735195935697737	0.713698837334198	0.676970728672608	0.693129728372522	NA	NA	p.Gln179Arg	1	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.142	-2.053	-0.089	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179S	179	Q	S	missense	wt-like	0.953506509267816	0.258904640469954	6	0.10569737686502	0.74634345735202	1.16066956118361	0.980995148959329	1.23911190048286	0.558520746754439	0.982090366795204	NA	NA	0.762697408916875	1.19762348369819	0.700317833795068	0.682231173847238	0.7252381908082	0.585639001319449	0.718404493742897	NA	NA	0.6426224460606	0.74100564601763	NA	NA	p.Gln179Ser	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.142	-2.642	0.5	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179T	179	Q	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Thr	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.142	-3.26	1.118	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179V	179	Q	V	missense	wt-like	1.11533839240482	0.170451042185759	6	0.0695863465801199	0.978951659292063	1.25172512551758	1.00015130660122	1.25636974768386	1.20430121459128	1.33242621323552	NA	NA	0.980944532226577	0.917837340090463	0.708243263646382	0.686311411860108	0.728969540490268	0.778866205907777	0.834437082767477	NA	NA	0.687516986802497	0.678081328991538	NA	NA	p.Gln179Val	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.142	-2.982	0.84	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179W	179	Q	W	missense	possibly_wt-like	0.790058433950405	0.401634881632495	6	0.163966753817122	0.4686895018069	1.11142736609391	1.23213263673195	1.18803756835056	0.672249280464407	0.882962815449238	NA	NA	0.161133653137324	0.603834649568946	0.652620674866148	0.735723149807255	0.714195319078949	0.619668284868884	0.685573064863412	NA	NA	0.518877728910907	0.607461660016351	NA	NA	p.Gln179Trp	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.142	-4.512	2.37	0.007530625	NA	NA	NA	NA	NA	NA	NA
Q179X	179	Q	X	nonsense	possibly_wt-like	0.832863525671344	0.635624026821016	6	0.259492422327436	0.324267723648511	1.34145932769418	0.18394437628215	-0.0238247643481805	0.99757986942397	0.909562933264278	NA	NA	1.59336116788331	1.33655757152253	0.705697602448598	0.512460339755107	0.452176419667029	0.717012078003881	0.694383126893316	NA	NA	0.813494196414975	0.772252127616973	NA	NA	p.Gln179Ter	1	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q179Y	179	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln179Tyr	0	30.9	27.4	18.3	0.982	21.1	-167.8	-123.4	114.3	15.4205607476636	-4.8	0	1	13.67	1	123	0	0	6	20.4447757098591	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.142	-4.679	2.537	0.007530625	NA	NA	NA	NA	NA	NA	NA
Y180A	180	Y	A	missense	low	0.206490497758038	0.104026827919531	6	0.042468774660527	0.123253228955858	0.289727766560218	0.228782392001974	0.356823469791652	0.222342790422389	0.180495268148678	NA	NA	0.0333698895884744	0.217129176595061	0.506543551142914	0.522010781946164	0.53447704794904	0.485049513124102	0.452913092875883	NA	NA	0.49259607442219	0.520491027863638	NA	NA	p.Tyr180Ala	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.249	-3.208	0.959	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180C	180	Y	C	missense	low	0.248628571908431	0.252103399442593	5	0.112744067702484	0.0276542597410166	0.469602884075846	NA	0.478554578144357	0.0276060601225321	0.231741732702539	NA	NA	0.528473959819783	-0.0232334712470549	0.469886120389224	NA	0.560796746296078	0.426781361793116	0.469886120389224	NA	NA	0.594441494033686	0.466433113275653	NA	NA	p.Tyr180Cys	1	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.249	-3.235	0.986	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180D	180	Y	D	missense	low	0.00398402990560314	0.236817721712182	6	0.0966804300405452	-0.18550613098371	0.193474190794916	-0.137710908331385	-0.153542938910263	0.191607680876599	0.402795314927948	NA	NA	-0.136288740648294	-0.142956228480985	0.450822296539405	0.443948159815099	0.424129823601295	0.475853107230715	0.526539729231174	NA	NA	0.457696433263711	0.439507288307037	NA	NA	p.Tyr180Asp	1	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.249	-3.752	1.503	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180E	180	Y	E	missense	low	0.0454340888734857	0.134993270143104	6	0.0551107717600485	-0.0625810389364164	0.153449216683388	-0.0872950184778157	-0.158453717789632	0.105034244648383	0.0951199119371046	NA	NA	0.153263262706075	0.1649358502168	0.452317859294708	0.454686682335049	0.423068055409885	0.449949036254368	0.424636444280598	NA	NA	0.517258749661549	0.508752671655846	NA	NA	p.Tyr180Glu	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.249	-3.68	1.431	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180F	180	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Phe	1	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.249	-3.17	0.921	0.008167542	1.022364217	0.00881917085413937	1.2	0.17	0.0001848	NA	NA
Y180G	180	Y	G	missense	low	-0.121373174054993	0.14723147367651	6	0.0601069974309104	-0.239180724238419	-0.00356562387156659	0.0485183465186543	0.0671652389497704	-0.192186213367206	-0.132708802613755	NA	NA	-0.277776068018682	-0.241251545798736	0.422996149144092	0.48361476200915	0.47184952929205	0.361016216032675	0.349178691749465	NA	NA	0.428591772057808	0.417400526230376	NA	NA	p.Tyr180Gly	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.249	-2.058	-0.191	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180H	180	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180His	1	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.249	-3.705	1.456	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180I	180	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Ile	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.249	-2.223	-0.026	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180K	180	Y	K	missense	low	-0.109935712934732	0.203126994725319	6	0.0829262483436736	-0.272468173061356	0.052596747191893	0.171786079255792	0.0401335002982448	-0.0520996251953173	-0.306059163164223	NA	NA	-0.355513968093996	-0.157861100708889	0.424377926030855	0.509870637444963	0.46600494924401	0.402932224925668	0.291764381031929	NA	NA	0.41260069153773	0.436155160523979	NA	NA	p.Tyr180Lys	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.249	-3.691	1.442	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180L	180	Y	L	missense	possibly_low	0.66500816655483	0.203297627091012	6	0.0829959087152654	0.502339174608736	0.827677158500924	0.368257923321253	1.00597501205479	0.68241118576925	0.653239709763452	NA	NA	0.622102062091419	0.658063106328813	0.61667949491627	0.551718898542028	0.674831251612222	0.622708879394642	0.609487882652319	NA	NA	0.613701269779071	0.619657720053469	NA	NA	p.Tyr180Leu	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.249	-2.459	0.21	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180M	180	Y	M	missense	wt-like	0.891766347419837	0.0490621098900879	6	0.0200295224891786	0.852509204713512	0.931023490126162	0.849858779520387	0.880268912868883	0.848316635209256	0.953850562707729	NA	NA	0.952741715214804	0.865561478997964	0.669337344771352	0.654299288473507	0.647652113463165	0.67235027893812	0.709051361269841	NA	NA	0.681715524230298	0.666324410604585	NA	NA	p.Tyr180Met	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.249	-3.121	0.872	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180N	180	Y	N	missense	low	0.20337586451773	0.246994926398948	6	0.100835256455618	0.00574239349285799	0.401009335542602	0.359134881008725	0.468571259577727	-0.144086897625217	0.397072303310764	NA	NA	-0.0210465364969796	0.16061017733136	0.516212033527327	0.549775701752125	0.558638235322739	0.375408252934268	0.52464424562107	NA	NA	0.481402339444731	0.507779821433584	NA	NA	p.Tyr180Asn	1	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.249	-3.798	1.549	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180P	180	Y	P	missense	low	0.182395760530197	0.353680332967355	6	0.144389391304613	-0.100602246176505	0.465393767236898	-0.242955903978222	-0.253517363389942	0.519928577516334	0.187871370299953	NA	NA	0.38561604173885	0.497431840994208	0.510205490918091	0.421531105208939	0.40251417637413	0.574091645287054	0.455356086472509	NA	NA	0.565054895363673	0.583531511178778	NA	NA	p.Tyr180Pro	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.249	-4.527	2.278	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180Q	180	Y	Q	missense	low	0.0805064702152401	0.200152619657252	6	0.0817119648069368	-0.0796460379123603	0.240658978342841	-0.0562424964524264	-0.0468050956993699	0.279526233246746	0.353286520451471	NA	NA	0.0987048740612819	-0.145431214316262	0.481730244232393	0.461300831327349	0.447207801560589	0.502159657137437	0.51014222477663	NA	NA	0.506035812265256	0.438950660336381	NA	NA	p.Tyr180Gln	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.249	-2.896	0.647	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180R	180	Y	R	missense	low	-0.0533936538245192	0.0292250367819063	6	0.0119310713049568	-0.0767781238792137	-0.0300091837698246	-0.0908693904614877	-0.0286698036940195	-0.0769300845617943	-0.0496714924020821	NA	NA	-0.0611596815392937	-0.0130614702884377	0.452527105318008	0.453925345499523	0.451128865136494	0.395502578953098	0.376680970455447	NA	NA	0.473150861958669	0.468720811318366	NA	NA	p.Tyr180Arg	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.249	-3.668	1.419	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180S	180	Y	S	missense	low	0.0165741021389919	0.132316136202341	6	0.0540178364053894	-0.0892989117383479	0.122447116016332	0.143569912299785	0.133371413635073	-0.114541735863401	-0.000522553624711615	NA	NA	0.10241904719942	-0.164851470812214	0.460373549718596	0.503860628593313	0.48616408347634	0.384248608597964	0.392959289308897	NA	NA	0.506799836527038	0.434583015960851	NA	NA	p.Tyr180Ser	1	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.249	-3.179	0.93	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180T	180	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Thr	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.249	-3.077	0.828	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180V	180	Y	V	missense	possibly_wt-like	0.769256410136262	0.100572974473749	6	0.0410587448957736	0.688782748890128	0.849730071382396	0.780376285805727	0.941488136560772	0.811748960885338	0.709305607218939	NA	NA	0.71483322843799	0.657786241908806	0.636138072019539	0.639499602785834	0.660888430148476	0.661408682157444	0.628057125006041	NA	NA	0.632776541253244	0.619595452836397	NA	NA	p.Tyr180Val	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.249	-2.834	0.585	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180W	180	Y	W	missense	wt-like	0.905370829718292	0.149411323290515	6	0.0609969173092961	0.785819068624103	1.02492259081248	1.08491786421017	1.00660699517598	0.951512647260102	0.912179082093393	NA	NA	0.66344271494566	0.813565674624447	0.685108749658899	0.704366584355648	0.674967893801183	0.703228073988258	0.695249605516615	NA	NA	0.622205251850934	0.654630477387459	NA	NA	p.Tyr180Trp	0	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.249	-4.314	2.065	0.008167542	NA	NA	NA	NA	NA	NA	NA
Y180X	180	Y	X	nonsense	low	-0.235981864787296	0.126040967066189	6	0.0514560093331837	-0.336833789868493	-0.135129939706099	-0.111196354539522	-0.105864980661617	-0.245043072717437	-0.189546584911736	NA	NA	-0.413573974530786	-0.350666221362679	0.396725228825222	0.449595727156017	0.434438359323086	0.34520065070631	0.330353798146767	NA	NA	0.400657453592952	0.392793004057492	NA	NA	p.Tyr180Ter	1	30.5	24	16.6	0.931	6.4	-160.5	-104.1	111.2	0	-7.3	0	1	13.53	1	29	0	0	7	17.1826942328371	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L181A	181	L	A	missense	wt-like	1.05105167108212	0.0677999469735862	6	0.0276792124455071	0.996801411568498	1.10530193059575	0.997569379593996	1.04056847252431	1.06048857484761	1.05348963503965	NA	NA	1.1734354371963	0.980758527290889	0.709672869840288	0.685761464583714	0.682310764915426	0.735835306482745	0.74205220788075	NA	NA	0.727113342734046	0.692232396946529	NA	NA	p.Leu181Ala	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.006	-3.091	2.085	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181C	181	L	C	missense	wt-like	1.03572998258495	0.122800123465977	6	0.0501329404737363	0.937471224817337	1.13398874035256	0.964107177972487	1.0076821581903	0.913264357098374	1.03125440649537	NA	NA	1.26901198702598	1.02905980872719	0.697439519115932	0.678634056801696	0.675200356699073	0.691783611734715	0.734687814080455	NA	NA	0.746773924029358	0.703095426497148	NA	NA	p.Leu181Cys	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.006	-3.861	2.855	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181D	181	L	D	missense	low	-0.20800697259714	0.208079294266751	6	0.0849480161653281	-0.374502024839309	-0.0415119203549707	-0.0768036356249267	0.0811872034776385	-0.149000538019402	-0.21471789667317	NA	NA	-0.430367181693622	-0.458339787049359	0.385570511836519	0.456921333976791	0.474881243055282	0.373938018009231	0.322016962214902	NA	NA	0.397203005663807	0.368577060068152	NA	NA	p.Leu181Asp	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.006	-4.409	3.403	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181E	181	L	E	missense	low	0.155094575899834	0.165687718503612	6	0.0676417278299573	0.0225192255010573	0.287669926298611	0.0240768123286514	-0.0293522717365935	0.215518438135498	0.438015924738285	NA	NA	0.172710651391763	0.109597900541402	0.489657324778711	0.478408745293314	0.450981307513343	0.483007564534454	0.538204931592972	NA	NA	0.521259176198371	0.496307085022968	NA	NA	p.Leu181Glu	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.006	-4.218	3.212	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181F	181	L	F	missense	wt-like	1.05672494605151	0.254471147946086	6	0.103887411121366	0.853109361806523	1.26034053029649	1.13858624960654	1.3045114145009	0.756426777999517	0.724812545959862	NA	NA	1.13886350340395	1.27714918483828	0.717899802472848	0.715797884425172	0.739378335462189	0.644855455042107	0.633193083168009	NA	NA	0.720001720520524	0.758891093687537	NA	NA	p.Leu181Phe	1	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.006	-2.393	1.387	0.004142735	NA	NA	NA	NA	4.06e-06	NA	NA
L181G	181	L	G	missense	possibly_wt-like	0.81191632819961	0.140017344315488	6	0.0571618414520881	0.699881177663529	0.923951478735692	0.908046708912856	0.968022609181815	0.746121818065913	0.9255222489505	NA	NA	0.628995355673898	0.694789228412679	0.654198775926654	0.666693245854506	0.666625495428126	0.641772056425183	0.699668914051406	NA	NA	0.615119255248439	0.627917479165715	NA	NA	p.Leu181Gly	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.006	-3.408	2.402	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181H	181	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181His	1	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.006	-5.165	4.159	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181I	181	L	I	missense	wt-like	1.05204822284073	0.394498531382824	6	0.161053351027542	0.736389455237262	1.3677069904442	0.586258258853941	0.525723682457819	1.28659905435597	1.23033083157304	NA	NA	1.46331438375894	1.22006312604467	0.766397633870182	0.598152701838444	0.570995261808097	0.803490954275682	0.800622696994173	NA	NA	0.786742913008874	0.74605235473149	NA	NA	p.Leu181Ile	1	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.006	-2.452	1.446	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181K	181	L	K	missense	low	-0.0739214183359612	0.192169982128729	6	0.0784530666825249	-0.227686603510429	0.0798437668385068	0.0512857294188693	0.177406107546056	-0.039973260821626	-0.0351878420155656	NA	NA	-0.332098188751631	-0.26496105539187	0.414742829333335	0.484204211162614	0.495684902568722	0.406560615077505	0.381478011551727	NA	NA	0.417417436169903	0.412068222496767	NA	NA	p.Leu181Lys	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.006	-3.461	2.455	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181L	181	L	L	synonymous	wt-like	1.14834763760064	0.252954575163868	6	0.103268272875662	0.945945542018688	1.35074973318259	0.712482733639539	1.21001610332384	1.22442466975724	1.01654501132107	NA	NA	1.43601610608617	1.29060120147597	0.745866238769156	0.625038359693357	0.718947337017784	0.78488744560461	0.729816005436262	NA	NA	0.781127518768718	0.76191647210205	NA	NA	p.Leu181=	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181M	181	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Met	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.006	-2.885	1.879	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181N	181	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Asn	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.006	-4.46	3.454	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181P	181	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Pro	1	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.006	-4.478	3.472	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181Q	181	L	Q	missense	low	0.4489052975318	0.288766632903497	6	0.117888484225859	0.217848114257099	0.679962480806501	0.923273604464534	0.611090630009171	0.235460618246918	0.348643468410046	NA	NA	0.1173710795026	0.457592384557531	0.542223552007955	0.669936555875722	0.58945260059983	0.488974564015306	0.508604427960186	NA	NA	0.509875545444661	0.574571558571249	NA	NA	p.Leu181Gln	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.006	-4.507	3.501	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181R	181	L	R	missense	low	0.250528839743937	0.0819086306797034	6	0.0334390584492248	0.184989489506527	0.316068189981348	0.198110159853841	0.34106152601911	0.253235651349663	0.357767896368617	NA	NA	0.184648389631872	0.168349415240522	0.513552054032264	0.515477634229908	0.531069130194325	0.494293120597566	0.511626473834619	NA	NA	0.523714829531433	0.509520387472548	NA	NA	p.Leu181Arg	1	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.006	-4.343	3.337	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181S	181	L	S	missense	low	0.486806764722886	0.178817085539975	6	0.0730017694774252	0.343725925739437	0.629887603706335	0.656141333753805	0.765511830904923	0.411555234259826	0.357174224374386	NA	NA	0.337867169564029	0.392590795480348	0.557592657610189	0.613037710825793	0.622840281702572	0.541664715064945	0.511429847371122	NA	NA	0.555232710059585	0.559952605160793	NA	NA	p.Leu181Ser	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.006	-3.95	2.944	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181T	181	L	T	missense	possibly_low	0.609838960462297	0.17205952796491	6	0.0702430081496937	0.472165194323144	0.74751272660145	0.703132053839636	0.723849331423668	0.398029026034093	0.842231585995461	NA	NA	0.523141150336411	0.468650615144513	0.603588433513814	0.623046676398671	0.613832358965575	0.53761747063079	0.672082723935707	NA	NA	0.593344508062052	0.57705857096661	NA	NA	p.Leu181Thr	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.006	-3.851	2.845	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181V	181	L	V	missense	possibly_wt-like	0.783121171005071	0.145145737485186	6	0.059255499196444	0.666982526694099	0.899259815316044	0.939874440008527	0.986185752524755	0.684224220715277	0.763034189591018	NA	NA	0.675838748391222	0.649569674799629	0.635303709193086	0.673472513425156	0.670552580791015	0.623251366651364	0.645852239552833	NA	NA	0.624755178833339	0.61774753475519	NA	NA	p.Leu181Val	1	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.006	-2.725	1.719	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181W	181	L	W	missense	possibly_low	0.645306938910479	0.142603332953903	6	0.0582175668928798	0.531202604532883	0.759411273288075	0.460147624246373	0.839528159381244	0.588513810390408	0.780032074548332	NA	NA	0.55431047457141	0.649309490325106	0.608722607552932	0.571291291801413	0.638843483058529	0.594613375943741	0.651482004875393	NA	NA	0.599756196223366	0.617689018882498	NA	NA	p.Leu181Trp	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.006	-5.385	4.379	0.004142735	NA	NA	NA	NA	NA	NA	NA
L181X	181	L	X	nonsense	low	-0.0659917691498638	0.0224153314516859	2	0.0158500328720312	-0.097057262732821	-0.0349262755669067	-0.0818418020218951	-0.0501417362778326	NA	NA	NA	NA	NA	NA	0.451167295664329	0.455848210731912	0.446486380596745	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Ter	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L181Y	181	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Tyr	0	31.1	21.2	19.1	0.829	14.2	-174.8	-96.5	123.8	0	-6.4	0	1	13.12	0	0	0	0	7	16.1441658251544	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.006	-3.505	2.499	0.004142735	NA	NA	NA	NA	NA	NA	NA
L182A	182	L	A	missense	possibly_low	0.484521786467837	0.477666037974978	6	0.195006343415931	0.102316376615762	0.866727196319912	1.03215337200343	0.911106766261724	0.359803160039829	0.714690631731767	NA	NA	-0.116860387846234	0.00623717661650215	0.578010192001451	0.693127812423595	0.654319620314561	0.526179718024581	0.62984066597832	NA	NA	0.461692944022675	0.473061105517223	NA	NA	p.Leu182Ala	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.135	-2.961	1.826	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182C	182	L	C	missense	possibly_wt-like	0.891249896107082	0.244915919762468	6	0.0999865055504123	0.69527994628826	1.0872198459259	0.672390068724489	0.712548175035025	0.845686368361921	0.726714390866116	NA	NA	1.13890434261721	1.25125603103773	0.652693122600767	0.616498671386247	0.611388915944749	0.671563263635637	0.633822981565898	NA	NA	0.720010121353927	0.753067685145778	NA	NA	p.Leu182Cys	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.135	-5.091	3.956	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182D	182	L	D	missense	low	-0.18521851719992	0.448230389141986	6	0.182989290101168	-0.543870935354761	0.173433900954921	0.217411076061241	0.156752086046477	0.0217742735291955	-0.0100839640502839	NA	NA	-0.841378633345609	-0.655785941440544	0.40741445844978	0.519588705639157	0.491219260031836	0.425036403750391	0.389792513149168	NA	NA	0.31265586441516	0.324171128257915	NA	NA	p.Leu182Asp	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.135	-4.376	3.241	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182E	182	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Glu	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.135	-4.177	3.042	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182F	182	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Phe	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.135	-3.503	2.368	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182G	182	L	G	missense	low	-0.0710237964685143	0.0562236363141956	6	0.0229532034089323	-0.116011248479844	-0.0260363444571849	-0.0803219525749321	-0.00471944398002499	-0.054422272269316	-0.0170764999130467	NA	NA	-0.133879099446817	-0.135723510626949	0.4486529370159	0.45617193679448	0.456307214791776	0.402237254074572	0.387476558192667	NA	NA	0.458192108686381	0.44113393723732	NA	NA	p.Leu182Gly	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.135	-4.073	2.938	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182H	182	L	H	missense	low	-0.0618849042908566	0.26006192680082	6	0.106169837031173	-0.269973961116442	0.146204152534729	0.390763634165736	-0.220038928329801	-0.241991722512906	-0.22449540249513	NA	NA	0.117491229922729	-0.193038236495768	0.418998189389359	0.556512587266613	0.409752608060473	0.346113660466758	0.318778614423054	NA	NA	0.509900260995775	0.428243770718246	NA	NA	p.Leu182His	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.135	-5.236	4.101	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182I	182	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Ile	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.135	-2.069	0.934	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182K	182	L	K	missense	low	-0.298285292048683	0.13149745862216	6	0.0536836126828392	-0.403503239467045	-0.19306734463032	-0.338455630726322	-0.328289497744815	-0.135478607445127	-0.140493108382717	NA	NA	-0.399172170087591	-0.447822737905524	0.382165771698811	0.401189780890115	0.386347560891731	0.377983982505891	0.346600499533883	NA	NA	0.40361997784769	0.370942359957461	NA	NA	p.Leu182Lys	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.135	-4.087	2.952	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182L	182	L	L	synonymous	wt-like	1.00390087216129	0.0535834700848601	6	0.0218753600592657	0.961025954296288	1.0467757900263	1.02393596186476	0.917936498839759	1.03857705913517	1.00516406830238	NA	NA	0.969343161747379	1.06844848307832	0.70166575586018	0.691377514172665	0.655796288880858	0.729279052244225	0.726046593035508	NA	NA	0.685130526024725	0.711953997547695	NA	NA	p.Leu182=	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182M	182	L	M	missense	wt-like	0.922804743708133	0.0729534915619766	6	0.0297831382135468	0.864430865463003	0.981178621953263	0.902553340390106	0.994182392454923	0.866002171105539	0.950444169044237	NA	NA	1.00367773357533	0.819968655678663	0.674961802537154	0.665523165116801	0.672281548460825	0.677642056613484	0.707923150497155	NA	NA	0.692193321677697	0.656070517285691	NA	NA	p.Leu182Met	1	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.135	-2.696	1.561	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182N	182	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Asn	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.135	-3.668	2.533	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182P	182	L	P	missense	possibly_wt-like	0.976720480397581	0.45258288881323	2	0.320024429728832	0.3494841239561	1.60395683683906	1.29674491012641	0.656696050668748	NA	NA	NA	NA	NA	NA	0.674399256929909	0.749485484557804	0.599313029302015	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Pro	1	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.135	-4.444	3.309	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182Q	182	L	Q	missense	low	-0.0836358576871867	0.325416679103872	6	0.132850802932583	-0.344018646752278	0.176746931377905	0.162834305880906	0.459073737217742	-0.251157725652254	-0.339345258962194	NA	NA	-0.349642646317869	-0.183577558289451	0.422089971721874	0.507963920728092	0.556584759206882	0.343371054810386	0.280739897202476	NA	NA	0.41380845222062	0.430371491223128	NA	NA	p.Leu182Gln	1	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.135	-3.706	2.571	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182R	182	L	R	missense	low	-0.0221118626710324	0.150270408875298	6	0.0613476375306459	-0.142351022767716	0.0981272974256514	0.239171592137235	-0.00453778395270195	0.0215266604189055	-0.177805528509218	NA	NA	-0.15172847677579	-0.0592976393446251	0.455433446511177	0.524223668794751	0.456346491827742	0.424962314192866	0.334242481494789	NA	NA	0.454520401194613	0.45832222859283	NA	NA	p.Leu182Arg	1	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.135	-4.367	3.232	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182S	182	L	S	missense	low	0.0782782921704915	0.118046822226426	6	0.0481924133686299	-0.0161771023600897	0.172733686701073	0.018230734204798	0.284700078482947	0.0613961614390214	-0.0721975739478605	NA	NA	0.10124908291099	0.0762912699330531	0.482989956219823	0.477163537844457	0.518883121887754	0.436891867058182	0.369220245014721	NA	NA	0.50655916893602	0.488816374595188	NA	NA	p.Leu182Ser	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.135	-3.944	2.809	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182T	182	L	T	missense	low	0.486952186252242	0.246200457805396	6	0.100510916010473	0.289954410818583	0.6839499616859	0.629284993154778	0.909231479718524	0.468142128318792	0.324160894461814	NA	NA	0.341768819682302	0.249124802177239	0.5573158310126	0.607317343315396	0.65391416129263	0.558596362737683	0.500495704659206	NA	NA	0.556035299287516	0.527686891324281	NA	NA	p.Leu182Thr	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.135	-3.321	2.186	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182V	182	L	V	missense	possibly_wt-like	0.799379944472957	0.144603815481615	6	0.0590342604649213	0.683674920107755	0.91508496883816	0.821232150495468	0.972946339712927	0.880125407081649	0.819383346368775	NA	NA	0.758932067803457	0.543660355375468	0.656358575098563	0.648201851706107	0.667690063919078	0.681867940707728	0.66451529849102	NA	NA	0.641847896286656	0.593928372356614	NA	NA	p.Leu182Val	1	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.135	-2.077	0.942	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182W	182	L	W	missense	low	0.0644542450362446	0.0910583619436727	6	0.0371744205959441	-0.00840628047794979	0.137314770550439	0.010430467857156	-0.0117507216635445	0.0617828265140521	0.242512185833587	NA	NA	0.0425759684838088	0.0411747431924079	0.474477713441461	0.475502090707869	0.454786969801578	0.437007563049748	0.473453336175052	NA	NA	0.494489811566451	0.480918615853491	NA	NA	p.Leu182Trp	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.135	-4.008	2.873	0.006077537	NA	NA	NA	NA	NA	NA	NA
L182X	182	L	X	nonsense	low	-0.130034629682178	0.0645182936139309	6	0.0263394830715329	-0.181659067873784	-0.0784101914905707	-0.106544685684759	-0.178721722348963	-0.0858160539902013	-0.0501872238137811	NA	NA	-0.131134654261398	-0.227803437993963	0.419555449910659	0.450586526899854	0.418685874278729	0.392843763584371	0.376510158214711	NA	NA	0.458756654987484	0.42042502554259	NA	NA	p.Leu182Ter	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L182Y	182	L	Y	missense	possibly_low	0.148671850462531	0.679103202124848	3	0.392080416554318	-0.619791645027394	0.917135345952456	0.645664120916551	0.425466274324432	NA	NA	NA	NA	NA	-0.625114843853391	0.549318430184408	0.61080607737995	0.549318430184408	NA	NA	NA	NA	NA	0.331069103415749	NA	NA	p.Leu182Tyr	0	31.8	18	17.3	0.976	16.1	-164.6	-133.4	125.9	0	-6.5	0	1	13.25	0	0	0	0	6	14.2870729621727	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.135	-4.336	3.201	0.006077537	NA	NA	NA	NA	NA	NA	NA
C183A	183	C	A	missense	possibly_wt-like	0.804228027888522	0.14462399948576	6	0.0590425005501081	0.688506853253124	0.91994920252392	0.913568973610921	1.03917099916971	0.687789200282341	0.732869805697957	NA	NA	0.66883217649819	0.783137012072016	0.641824352511136	0.667869481442007	0.682008614728519	0.624318062023037	0.635861678795188	NA	NA	0.623313891440669	0.647787026227085	NA	NA	p.Cys183Ala	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.841	-2.756	-0.085	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183D	183	C	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys183Asp	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.841	-2.887	0.046	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183E	183	C	E	missense	wt-like	0.899574819917571	0.197724062812139	6	0.0807205106266251	0.741365526275703	1.05778411355944	0.583739976139303	0.834020031202553	0.919110386611612	0.900646673321656	NA	NA	1.19389629208628	0.966035560144025	0.690175603478413	0.59761631071808	0.637652560918069	0.69353283147276	0.691430027071899	NA	NA	0.731322244411841	0.688921179884926	NA	NA	p.Cys183Glu	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.841	-2.649	-0.192	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183F	183	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys183Phe	1	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.841	-4.511	1.67	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183G	183	C	G	missense	possibly_low	0.694283523294454	0.119518779937902	6	0.048793337587975	0.598650338936519	0.789916707652389	0.704833421204527	0.925458607779494	0.669435909416484	0.61973589474093	NA	NA	0.595128981295937	0.651108325329352	0.618460030787429	0.623409065554464	0.657422657365516	0.618826482042482	0.598391289372572	NA	NA	0.608152770186759	0.618093579532376	NA	NA	p.Cys183Gly	1	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.841	-3.555	0.714	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183H	183	C	H	missense	possibly_wt-like	0.82404681894812	0.202006265254621	6	0.0824687124531887	0.66241111268848	0.98568252520776	0.841161127909372	0.905493750281524	0.563386194908534	0.60084792786418	NA	NA	1.06727790777259	0.966114004952524	0.652776359788333	0.652446699379734	0.653106020196932	0.587094816403226	0.59213552159891	NA	NA	0.70527620024393	0.688938822238244	NA	NA	p.Cys183His	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.841	-4.228	1.387	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183I	183	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys183Ile	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.841	-1.911	-0.93	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183K	183	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys183Lys	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.841	-3.497	0.656	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183L	183	C	L	missense	wt-like	1.01121312086531	0.234428195965583	6	0.0957049102394769	0.823634943652298	1.19879129807832	1.18158724744518	1.39708356715887	0.885571363687211	0.836121046046421	NA	NA	0.789187935998119	0.977727564856062	0.687524090823405	0.724957044067336	0.759393524400044	0.683497452629522	0.67005888944138	NA	NA	0.648071681905215	0.691550729017288	NA	NA	p.Cys183Leu	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.841	-2.495	-0.346	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183M	183	C	M	missense	wt-like	1.07144368249884	0.250371589987945	6	0.102213773593298	0.871108367532042	1.27177899746563	0.632159099213712	1.05284477401661	1.25120187377352	0.992398165892103	NA	NA	1.3442790341176	1.15577914797948	0.726706634909368	0.607929524370382	0.684965045784687	0.792899586783311	0.721818476720977	NA	NA	0.762256737552549	0.73159479309776	NA	NA	p.Cys183Met	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.841	-4.097	1.256	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183N	183	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys183Asn	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.841	-2.952	0.111	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183P	183	C	P	missense	possibly_low	0.186500193975159	0.779024435579937	5	0.348390318818029	-0.496332283470604	0.869332671420923	0.578785602754906	1.35557414934189	-0.118537256353356	-0.330588020571643	NA	NA	-0.552733505296003	NA	0.383053088922779	0.596561035281801	0.750418699720565	0.383053088922779	0.283640328470032	NA	NA	0.372031631960944	NA	NA	NA	p.Cys183Pro	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.841	-3.85	1.009	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183Q	183	C	Q	missense	low	0.568540015901015	0.127151216171235	6	0.051909266632308	0.466799722837804	0.670280308964225	0.800978268857368	0.450974310979981	0.60233783883098	0.559721663396403	NA	NA	0.530146313505708	0.467081699835648	0.586649924608944	0.643887799832405	0.554833567927622	0.598749732654356	0.578514343544787	NA	NA	0.594785505673102	0.576705719595884	NA	NA	p.Cys183Gln	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.841	-3.702	0.861	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183R	183	C	R	missense	possibly_low	0.639064172307304	0.212004940324964	6	0.0865506544575597	0.469428006732116	0.808700337882492	0.689820177845214	1.02331330525031	0.595159708362873	0.467068232240597	NA	NA	0.626962453243994	0.432061156900833	0.605651502613992	0.620211263187398	0.678579994665119	0.596601928325172	0.54782716834346	NA	NA	0.614701076902811	0.568829547753916	NA	NA	p.Cys183Arg	1	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.841	-4.436	1.595	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183S	183	C	S	missense	wt-like	1.14533099345356	0.152853502372417	6	0.0624021810349532	1.0230249660683	1.26763702083882	0.996872733112015	1.12695606607017	1.24639370731601	1.04955208015428	NA	NA	1.05002743978995	1.40218393427894	0.721237882949133	0.685613079740028	0.700988779383723	0.791460911242545	0.740748074454445	NA	NA	0.70172769144382	0.787011593550865	NA	NA	p.Cys183Ser	1	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.841	-2.623	-0.218	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183T	183	C	T	missense	wt-like	1.01404165331106	0.188214729394244	6	0.0768383415153189	0.863441271309248	1.16464203531288	0.646370989238483	0.981750254576114	1.1005350431579	1.10947877354008	NA	NA	1.13950797305419	1.1066068862996	0.720335085000772	0.610956639462971	0.669593573930675	0.747817810616314	0.760596027371309	NA	NA	0.720134291197886	0.720535878803658	NA	NA	p.Cys183Thr	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.841	-3.015	0.174	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183V	183	C	V	missense	possibly_wt-like	0.834985445234933	0.216303835097779	6	0.0883056708994457	0.661909510641372	1.00806137982849	0.876745659626658	1.03415112313143	0.933615796529006	1.03032387945805	NA	NA	0.53938979929065	0.595686413373803	0.670474709654354	0.660026160861379	0.680923258447328	0.697873067743972	0.734379619922208	NA	NA	0.596686937604373	0.605629109658655	NA	NA	p.Cys183Val	0	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.841	-1.917	-0.924	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183W	183	C	W	missense	possibly_low	0.696218976147861	0.0904243398107754	6	0.0369155821440725	0.623865764677149	0.768572187618573	0.722675114674463	0.859866520302898	0.70482894578626	0.626922779864642	NA	NA	0.622797418011123	0.64022307824778	0.621427397849309	0.627209324315688	0.643240876063283	0.629416609524246	0.600771613556922	NA	NA	0.613844308020281	0.61564547138293	NA	NA	p.Cys183Trp	1	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.841	-5.869	3.028	0.006794035	NA	NA	NA	NA	NA	NA	NA
C183X	183	C	X	nonsense	possibly_low	0.533923455043042	0.29171667205505	5	0.130459661777021	0.278227216524804	0.78961969356128	0.347811064230517	0.330814954654327	0.601687602717147	NA	NA	NA	1.01733153130153	0.371972122311692	0.555315435105149	0.547363742708305	0.528853700867656	0.598555172253638	NA	NA	NA	0.695001977155051	0.555315435105149	NA	NA	p.Cys183Ter	1	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C183Y	183	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys183Tyr	1	32.3	14.4	18.6	0.904	15.8	175.3	-105.8	127.3	1.35135135135135	-4	0	1	14.36	0	0	0	0	6	13.6568237758502	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.841	-4.634	1.793	0.006794035	NA	NA	NA	NA	NA	NA	NA
V184A	184	V	A	missense	wt-like	0.910315241287848	0.166746889017877	6	0.0680741323817159	0.776892393540873	1.04373808903482	0.834370860033516	0.85750731424925	1.15911366626611	0.983990724165483	NA	NA	0.962406844417407	0.664502038595318	0.667352035513684	0.651000380675192	0.642730787947674	0.765345413502396	0.719033899463111	NA	NA	0.683703690352177	0.621105845432456	NA	NA	p.Val184Ala	1	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.27	-2.32	0.05	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184C	184	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val184Cys	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.27	-3.392	1.122	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184D	184	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val184Asp	1	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.27	-3.571	1.301	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184E	184	V	E	missense	low	0.201917484867144	0.25664642633552	6	0.104775464805136	-0.00343865261436677	0.407273622348654	0.255734566126844	0.63118057585017	-0.00606796721727505	0.055214671594698	NA	NA	-0.0482246390938297	0.323667701942255	0.501781613853593	0.527751561879676	0.59379628334041	0.416705587603324	0.41141967414524	NA	NA	0.47581166582751	0.544451699603831	NA	NA	p.Val184Glu	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.27	-4.021	1.751	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184F	184	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val184Phe	1	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.27	-3.218	0.948	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184G	184	V	G	missense	possibly_low	0.685775666505502	0.218616305260884	6	0.089249732890282	0.51084940441073	0.860701928600275	0.93472167336124	0.96658230428223	0.65707783760056	0.592926570736114	NA	NA	0.42981488712933	0.53353072592354	0.603389482637993	0.672374980467935	0.666314084557086	0.615128761547635	0.589511937442459	NA	NA	0.574146822143903	0.591650203728351	NA	NA	p.Val184Gly	1	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.27	-2.816	0.546	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184H	184	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val184His	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.27	-5.116	2.846	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184I	184	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val184Ile	1	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.27	-2.921	0.651	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184K	184	V	K	missense	possibly_wt-like	0.789495355892782	0.150490101300141	6	0.0614373265875162	0.669080408474825	0.909910303310739	0.586177485002042	0.800614845110416	0.667416767487767	0.78251181404223	NA	NA	0.899045070471219	1.00120615324302	0.641366635359668	0.598135497107354	0.630429966520716	0.618222324484327	0.652303304198619	NA	NA	0.670669851927332	0.696831098230488	NA	NA	p.Val184Lys	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.27	-4.039	1.769	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184L	184	V	L	missense	wt-like	1.074790995559	0.0810166068183461	6	0.0330748912327727	1.00996539995019	1.13961659116782	1.0250659407767	1.0549615570378	0.997315148976903	1.02181458768349	NA	NA	1.19869320860203	1.15089553027709	0.723714664968221	0.69161819829087	0.685422719187468	0.716932869674531	0.731561309534047	NA	NA	0.732308994480691	0.730496460261912	NA	NA	p.Val184Leu	1	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.27	-2.878	0.608	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184M	184	V	M	missense	low	0.634249794400274	0.0988783453909392	6	0.0403669154697463	0.555132093912598	0.713367494887949	0.548217651662618	0.740427562139642	0.529616814142833	0.614261506332973	NA	NA	0.768354018660186	0.604621213463389	0.602108355065183	0.59005009930216	0.617416767564795	0.576990511037824	0.596578150732163	NA	NA	0.643786039388801	0.607638559398204	NA	NA	p.Val184Met	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.27	-4.002	1.732	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184N	184	V	N	missense	possibly_low	0.627700524098097	0.136856103136695	6	0.0558712701451019	0.518194846843189	0.737206201353005	0.645736399042121	0.478660592258665	0.62505945684557	0.558006476925772	NA	NA	0.578419578097994	0.88032064141846	0.605131971407025	0.610821472531784	0.560819667795331	0.605548381655602	0.577946267143615	NA	NA	0.604715561158449	0.669643768036699	NA	NA	p.Val184Asn	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.27	-3.42	1.15	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184P	184	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val184Pro	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.27	-4.313	2.043	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184Q	184	V	Q	missense	wt-like	0.882467932312384	0.1237041777632	6	0.0505020190950644	0.783485793739504	0.981450070885264	0.750345337339398	0.838437855587763	1.04818431323645	0.824625268064426	NA	NA	1.02610601634004	0.807108803306225	0.659714880372661	0.63310304770493	0.638607746545986	0.732153686808474	0.666251443256081	NA	NA	0.696806933252876	0.653178317489241	NA	NA	p.Val184Gln	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.27	-4.463	2.193	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184R	184	V	R	missense	low	0.426038446302277	0.164736694710661	6	0.0672534739922947	0.294224059442178	0.557852833162376	0.612515700779336	0.649676748974797	0.384096262026569	0.258180884726546	NA	NA	0.347146900631312	0.304614180675102	0.548654066176197	0.60374550466809	0.597795373661713	0.533448578607189	0.478642869925794	NA	NA	0.557141597829357	0.540166534523037	NA	NA	p.Val184Arg	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.27	-4.353	2.083	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184S	184	V	S	missense	wt-like	1.19034739906343	0.194239215214892	6	0.0792978275525222	1.03492651300822	1.34576828511864	1.13426911652438	1.14468279178528	1.36554377632127	1.36219276564018	NA	NA	1.28345706108323	0.85193888302626	0.732311844726324	0.714878340389372	0.704821506119033	0.82711239949135	0.844295880195554	NA	NA	0.749745349063276	0.663260668645856	NA	NA	p.Val184Ser	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.27	-2.201	-0.069	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184T	184	V	T	missense	wt-like	1.30047494377892	0.362111840161927	6	0.14783153970283	1.01073045018227	1.59021943737558	0.875780361419598	0.870791802326635	1.57650661590077	1.23994966599099	NA	NA	1.67777576432686	1.5620454527087	0.813386588706031	0.659820553530732	0.645603050622541	0.8902356461583	0.803808492202553	NA	NA	0.830858707258344	0.822964685209508	NA	NA	p.Val184Thr	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.27	-1.515	-0.755	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184V	184	V	V	synonymous	wt-like	0.909740013502928	0.219471343987056	6	0.0895988009885222	0.734129590507453	1.0853504364984	0.68075940703545	0.783019477883165	1.12948901728012	0.775246073446406	NA	NA	0.858684556011843	1.23124154936058	0.65613217603673	0.618281330150981	0.626625641036512	0.756481274068684	0.649896862776536	NA	NA	0.662367489296925	0.748566398649148	NA	NA	p.Val184=	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184W	184	V	W	missense	low	-0.0326963262608777	0.149062324567427	6	0.0608544391772216	-0.151968835347615	0.08657618282586	0.109098379462176	0.19573244517544	-0.0695944206945433	-0.13557899048517	NA	NA	-0.160451751299408	-0.135383619723761	0.446968179281567	0.496518234503889	0.499647272457065	0.397697519638772	0.348228074411585	NA	NA	0.452725979359565	0.441210379203569	NA	NA	p.Val184Trp	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.27	-5.604	3.334	0.006643974	NA	NA	NA	NA	NA	NA	NA
V184X	184	V	X	nonsense	low	0.11779162211282	0.419486019694843	6	0.17125445041391	-0.217860932890645	0.453444177116284	0.603148512596432	0.682308143871755	-0.14888887128027	-0.132654388743536	NA	NA	0.00928055315468625	-0.30644421692215	0.445189686931919	0.601750305108132	0.604850665295488	0.373971430372909	0.349196713834001	NA	NA	0.487640775678402	0.402738598185437	NA	NA	p.Val184Ter	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V184Y	184	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val184Tyr	0	33.9	11.8	16.3	0.895	22.9	-128.1	-128.2	162	1.81818181818182	-5.6	0	1	13.55	0	0	0	0	5	14.1291053312943	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.27	-3.242	0.972	0.006643974	NA	NA	NA	NA	NA	NA	NA
L185A	185	L	A	missense	low	0.527586372574393	0.181013311678846	6	0.0738983750440913	0.38274821897194	0.672424526176845	0.763816622041961	0.656784827430042	0.327463330094643	0.595379551779987	NA	NA	0.509828250747564	0.31224565335216	0.590465175662413	0.635972414774941	0.59933222388267	0.516503155712156	0.590324374263415	NA	NA	0.590605977061412	0.5418828640021	NA	NA	p.Leu185Ala	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.639	-3.317	1.678	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185C	185	L	C	missense	possibly_wt-like	0.797297901603688	0.255967337677617	6	0.104498228021474	0.592485138233346	1.00211066497403	0.711075784105981	0.688183607591802	1.2714486399691	0.67116523776065	NA	NA	0.553816425138401	0.88809771505619	0.620081784057734	0.624738681173461	0.606121009703366	0.798957722990234	0.615424886942006	NA	NA	0.599654567747983	0.671392843386914	NA	NA	p.Leu185Cys	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.639	-3.911	2.272	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185D	185	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu185Asp	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.639	-3.585	1.946	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185E	185	L	E	missense	wt-like	1.01058721566794	0.154815805676435	6	0.0632032880041904	0.886711047475211	1.13446338386066	0.871095309011337	1.15861526715721	1.14589546563723	1.10848095955949	NA	NA	0.993060298740815	0.786375993901529	0.698921566364221	0.658822643131066	0.707833871273504	0.761390329562242	0.76026554751688	NA	NA	0.690009261454937	0.648515478025497	NA	NA	p.Leu185Glu	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.639	-3.521	1.882	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185F	185	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu185Phe	1	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.639	-2.066	0.427	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185G	185	L	G	missense	possibly_low	0.587384750452791	0.282378883766641	6	0.115280696560825	0.361438737080884	0.813330763824699	0.820951722290886	0.898376653383022	0.640398572382886	0.648002483350738	NA	NA	0.148000414928131	0.368578656381086	0.608945684069743	0.648142120843498	0.651567220082401	0.610138075156338	0.607753292983149	NA	NA	0.516176155167738	0.55455223960418	NA	NA	p.Leu185Gly	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.639	-3.622	1.983	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185H	185	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu185His	1	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.639	-4.139	2.5	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185I	185	L	I	missense	wt-like	0.870145409942591	0.0821996476171496	4	0.0410998238085748	0.789591235506843	0.95069958437834	0.914295237119497	0.912489197698813	NA	NA	NA	NA	0.906859748952789	0.746937455999267	0.661321346468895	0.668024174675924	0.654618518261865	NA	NA	NA	NA	0.672277370945935	0.639645692588636	NA	NA	p.Leu185Ile	1	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.639	-2.519	0.88	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185K	185	L	K	missense	possibly_low	0.592419368333034	0.162351119775469	6	0.066279567103229	0.462513803899799	0.722324932766268	0.680576347836062	0.862447155052903	0.533972448037135	0.508513665488876	NA	NA	0.391350719344445	0.577655874238782	0.589933898408493	0.618242338766701	0.643798839669161	0.578293782046353	0.561554056333675	NA	NA	0.566234547647294	0.601574014770632	NA	NA	p.Leu185Lys	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.639	-4.188	2.549	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185L	185	L	L	synonymous	possibly_wt-like	0.927878577287773	0.299539756771906	6	0.122286593628092	0.688201257984628	1.16755589659092	0.899332967571824	1.07061420491603	1.25992107999383	1.18674706429785	NA	NA	0.547192814838904	0.603463332108212	0.67682211777575	0.664837229668032	0.688807005883467	0.795508504098234	0.786187584493497	NA	NA	0.59829205749841	0.607378150170883	NA	NA	p.Leu185=	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185M	185	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu185Met	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.639	-2.657	1.018	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185N	185	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu185Asn	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.639	-4.481	2.842	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185P	185	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu185Pro	1	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.639	-4.57	2.931	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185Q	185	L	Q	missense	wt-like	0.994847320833441	0.16214801076739	6	0.0661966481979029	0.865104274468283	1.1245903671986	0.8713584913548	0.805461424775142	1.17571622018867	0.901861676826626	NA	NA	1.19002591017563	1.02466020167978	0.696969194655255	0.658878700646472	0.631477854086324	0.770313146723297	0.691832440937874	NA	NA	0.730526087212886	0.702105948372636	NA	NA	p.Leu185Gln	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.639	-3.907	2.268	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185R	185	L	R	missense	possibly_low	0.664442274863085	0.0999760105473645	6	0.0408150353933587	0.584446275464374	0.744438274261795	0.576614271063917	0.850259478101148	0.63420291081903	0.644886863931379	NA	NA	0.588983415242107	0.691706710020929	0.607586418163776	0.596098544302674	0.641163720468636	0.608284240263236	0.60672138776615	NA	NA	0.606888596064316	0.627224216225599	NA	NA	p.Leu185Arg	1	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.639	-3.86	2.221	0.007079832	NA	NA	NA	NA	4.08e-06	NA	NA
L185S	185	L	S	missense	wt-like	1.02582053345619	0.100260883969138	6	0.0409313344807965	0.945596592034671	1.10604447487772	0.900417110560322	1.00784645765834	0.937339303122442	1.10429853895122	NA	NA	1.16755545592144	1.03746633452341	0.701986631674002	0.66506815079093	0.675235880177793	0.698987196780308	0.758880313614901	NA	NA	0.725903800748325	0.704986066567697	NA	NA	p.Leu185Ser	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.639	-3.6	1.961	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185T	185	L	T	missense	possibly_wt-like	0.937487218505348	0.326446886834816	6	0.133271383477564	0.676280106719496	1.1986943302912	0.503938341161603	0.655874609625988	1.03662984392197	0.85463797145185	NA	NA	1.23862021089871	1.33522233397197	0.70244409154067	0.58061866063542	0.599135424080573	0.728696416238467	0.676191766842874	NA	NA	0.740522181459409	0.771951830719301	NA	NA	p.Leu185Thr	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.639	-3.257	1.618	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185V	185	L	V	missense	wt-like	1.03173919510643	0.0852023456608874	6	0.0347837119595684	0.963564372417062	1.0999140177958	1.10861792216113	0.884057141998173	0.984606234161643	1.04063436955828	NA	NA	1.07339023705076	1.09912926570861	0.711272419617647	0.709414667544691	0.648471173186695	0.713130171690602	0.737794494171014	NA	NA	0.706533537392962	0.718854150886038	NA	NA	p.Leu185Val	1	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.639	-2.255	0.616	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185W	185	L	W	missense	possibly_wt-like	0.837115583520285	0.176470940097594	6	0.0720439596113936	0.695912017378295	0.978319149662275	0.524676636996646	0.776739095598216	0.828365007711023	0.954191512413075	NA	NA	0.916042237956812	1.02267901044594	0.670273354093621	0.585035892137172	0.625267748469191	0.666380452657395	0.709164285132587	NA	NA	0.674166255529848	0.701660375537326	NA	NA	p.Leu185Trp	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.639	-5.423	3.784	0.007079832	NA	NA	NA	NA	NA	NA	NA
L185X	185	L	X	nonsense	low	-0.304366301494585	0.453649473676353	6	0.185201622098202	-0.667354810685459	0.058622207696289	0.234547293122224	0.21686927352293	-0.448443007530962	-0.308245356945092	NA	NA	-0.883046215022553	-0.637879796114056	0.316141439110063	0.523238698793112	0.504217303516892	0.284340338611217	0.29104030518562	NA	NA	0.304084631425494	0.328198246794632	NA	NA	p.Leu185Ter	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L185Y	185	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu185Tyr	0	34.9	8.2	16.9	0.906	10.6	-152.2	-113.5	138.5	12.565445026178	-2	0	1	13.12	0	0	0	0	5	15.3691124487659	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.639	-2.545	0.906	0.007079832	NA	NA	NA	NA	NA	NA	NA
S186A	186	S	A	missense	wt-like	1.22025032322726	0.34723358885425	6	0.14175751904138	0.942410691368405	1.49808995508611	0.706465813885111	0.85254405805436	1.36917224601094	1.44683876886045	NA	NA	1.50599154303891	1.44048950951379	0.795574197622299	0.623756763187348	0.641657673543014	0.828198092060246	0.872330964255685	NA	NA	0.7955218212345	0.795626574010098	NA	NA	p.Ser186Ala	1	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.481	-2.646	0.165	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186C	186	S	C	missense	wt-like	0.969694985198804	0.0864312094462371	6	0.0352853934991504	0.900536884760146	1.03885308563746	1.03621687680825	1.06118379213194	1.01918038503396	0.970535855145471	NA	NA	0.851300680674762	0.879752321398441	0.690380686798045	0.693993333948321	0.686768039647768	0.723475276345827	0.714577594739396	NA	NA	0.660848588671219	0.669515952024617	NA	NA	p.Ser186Cys	1	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.481	-4.339	1.858	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186D	186	S	D	missense	wt-like	1.50616570990273	0.459888194885411	4	0.229944097442706	1.05548356045746	1.956847859348	1.19516618808447	1.27617737539107	NA	NA	NA	NA	2.18808532300607	1.36523395312931	0.755976835465793	0.727849341719438	0.733252182727563	NA	NA	NA	NA	0.935831973002574	0.778701488204022	NA	NA	p.Ser186Asp	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.481	-1.961	-0.52	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186E	186	S	E	missense	wt-like	0.977812842318124	0.119907096544098	6	0.0489518671786135	0.881868945672053	1.0737567389642	0.985565082528919	0.934470553314953	0.953383448887019	1.20315787845581	NA	NA	0.944680092741438	0.84561999798061	0.681630885827683	0.68320456407588	0.659371146056886	0.703787845902573	0.791622909693865	NA	NA	0.680057207579486	0.661839542064186	NA	NA	p.Ser186Glu	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.481	-1.968	-0.513	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186F	186	S	F	missense	wt-like	1.06945838624518	0.066226131433463	6	0.0270367049417464	1.01646741829872	1.12244935419164	1.01610573664412	1.12581902932162	1.07958649362241	0.962764324121626	NA	NA	1.1209132414358	1.11156149232551	0.714156447057707	0.689709685832982	0.700742938656267	0.74154969030527	0.712003633568868	NA	NA	0.716309260546546	0.721650177018337	NA	NA	p.Ser186Phe	1	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.481	-3.767	1.286	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186G	186	S	G	missense	possibly_wt-like	0.767554739607049	0.148938261615488	6	0.0608037906891827	0.648381499732739	0.886727979481359	0.930054915729178	0.922773790581688	0.663076087365551	0.843742734126497	NA	NA	0.592766212021621	0.652914697817758	0.63767100183091	0.671380966833095	0.656842168288242	0.616923527868756	0.672583222048662	NA	NA	0.607666736557353	0.618499835373577	NA	NA	p.Ser186Gly	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.481	-3.096	0.615	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186H	186	S	H	missense	possibly_wt-like	1.05627989216783	0.324881285265779	3	0.187570297502869	0.688648864492739	1.42391091984291	0.684987831438575	1.19550929032465	1.28834255474025	NA	NA	NA	NA	NA	0.715810793308602	0.619181979347271	0.715810793308602	0.804012635748306	NA	NA	NA	NA	NA	NA	NA	p.Ser186His	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.481	-3.547	1.066	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186I	186	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser186Ile	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.481	-3.315	0.834	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186K	186	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser186Lys	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.481	-3.937	1.456	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186L	186	S	L	missense	wt-like	0.952396875130566	0.0827260688933922	6	0.0337727762025231	0.88620345011569	1.01859030014544	0.814091391337915	0.95367383347277	0.967093527852807	0.912026893509912	NA	NA	1.03197281195643	1.03552279265356	0.696606481475076	0.646680878789718	0.663523121241101	0.707890107220755	0.695199200068412	NA	NA	0.69801376288174	0.704548961129969	NA	NA	p.Ser186Leu	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.481	-2.733	0.252	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186M	186	S	M	missense	wt-like	0.780259582526973	0.0711638357623957	6	0.0290525142928492	0.723317700852653	0.837201464201292	0.703514692402934	0.788638990878361	0.790965365174246	0.789391685178197	NA	NA	0.899354789239601	0.709691972288498	0.642925536220277	0.623128177941952	0.627840645885251	0.655189918505455	0.654581944161309	NA	NA	0.67073356264963	0.631269128279245	NA	NA	p.Ser186Met	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.481	-4.215	1.734	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186N	186	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser186Asn	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.481	-2.68	0.199	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186P	186	S	P	missense	possibly_low	0.615163268418095	0.14321338571996	6	0.0584666198917155	0.50057079913254	0.729755737703651	0.73171174163288	0.758504284948336	0.631607742283551	0.667727907739169	NA	NA	0.375548921600707	0.525879012303928	0.610897078414996	0.629134114741469	0.621325167791049	0.60750772690224	0.614286429927753	NA	NA	0.562984037666483	0.589929322031406	NA	NA	p.Ser186Pro	1	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.481	-4.371	1.89	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186Q	186	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser186Gln	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.481	-2.99	0.509	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186R	186	S	R	missense	possibly_wt-like	0.764353513432304	0.207561060050783	6	0.0847364479325994	0.598273127306556	0.930433899558052	0.798576452232468	1.15082931985375	0.647228855069032	0.589475875809269	NA	NA	0.62161062063632	0.778399956992983	0.628488196811931	0.643376215845884	0.706150457829347	0.612181798210417	0.588369053919793	NA	NA	0.613600177777978	0.646721655541748	NA	NA	p.Ser186Arg	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.481	-3.625	1.144	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186S	186	S	S	synonymous	possibly_wt-like	0.837533105235075	0.165721159384416	6	0.0676553800123774	0.704930997050444	0.970135213419705	0.784563160213361	0.591915666091142	0.890132941074859	0.975918784457981	NA	NA	0.738891670692907	1.0437764088802	0.662626873452609	0.640391401884197	0.585306747719926	0.68486234502102	0.716360441773216	NA	NA	0.637725484907668	0.706405211612426	NA	NA	p.Ser186=	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186T	186	S	T	missense	wt-like	1.13610200329535	0.128459175230543	6	0.052443238682267	1.03331514424547	1.23888886234524	0.972969608155733	1.01598270320519	1.1599926203736	1.2145155399945	NA	NA	1.13071774565268	1.32243380239042	0.741967253287185	0.680521743528652	0.676995032225026	0.765608409758261	0.795384611178282	NA	NA	0.718326096816109	0.769075671074085	NA	NA	p.Ser186Thr	1	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.481	-2.928	0.447	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186V	186	S	V	missense	possibly_wt-like	0.772340181078353	0.198449534088515	6	0.0810166830349863	0.613550400182882	0.931129961973823	1.02043678304363	1.03016249967774	0.625445696605855	0.677769377966519	NA	NA	0.598898514975698	0.681328214200682	0.621251140468162	0.69063219338826	0.68006087111231	0.605663950386615	0.617612203752873	NA	NA	0.608928182392874	0.62489007718345	NA	NA	p.Ser186Val	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.481	-2.881	0.4	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186W	186	S	W	missense	wt-like	0.864765611595355	0.170507312495313	6	0.0696093188377993	0.728333853684903	1.00119736950581	1.08341098470124	1.05415218307936	0.801122042585255	0.66081030040875	NA	NA	0.850144267175192	0.738953891622331	0.659419828656588	0.704045620873927	0.68524772301168	0.658228948766943	0.611995291591326	NA	NA	0.660610708546232	0.637850177166125	NA	NA	p.Ser186Trp	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.481	-5.827	3.346	0.008090277	NA	NA	NA	NA	NA	NA	NA
S186X	186	S	X	nonsense	low	-0.0519175956066695	0.153766353362117	6	0.0627748508909466	-0.174954042487797	0.0711188512744579	0.0913870729816064	0.19139473277749	-0.162631843746775	-0.121367906349743	NA	NA	-0.148396780174458	-0.161890849128136	0.445227306121631	0.492745748011005	0.498709407983676	0.369859326825813	0.352934840509985	NA	NA	0.455205748091928	0.435248864151334	NA	NA	p.Ser186Ter	0	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S186Y	186	S	Y	missense	wt-like	1.05470287403939	0.15391247858839	6	0.0628345062647663	0.931549504774087	1.17785624330468	1.28476601994353	0.963465748906307	1.0647465477676	0.824443511797972	NA	NA	1.11488620363076	1.07590921219014	0.714350697416519	0.746933995684622	0.665640248604336	0.737109355862558	0.666191244876776	NA	NA	0.715069468286342	0.713631926546697	NA	NA	p.Ser186Tyr	1	38.3	6.6	16.1	0.941	38.2	126.4	-114.6	116.7	22.3776223776224	-6	0	1	15.79	0	0	0	0	5	18.8507617210236	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.481	-3.592	1.111	0.008090277	NA	NA	NA	NA	NA	NA	NA
Y187A	187	Y	A	missense	possibly_low	0.614583412020926	0.141034556580972	6	0.057577116620511	0.501734337111062	0.72743248693079	0.657649930270138	0.852920989772387	0.580684630253033	0.605149008314796	NA	NA	0.420657402649346	0.570438510865857	0.59675543759301	0.613359040027979	0.64173917061677	0.592270767785846	0.593560056100187	NA	NA	0.572263081117468	0.599950819085833	NA	NA	p.Tyr187Ala	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.125	-3.186	2.061	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187C	187	Y	C	missense	possibly_low	0.686867893301691	0.222956349008749	6	0.0910215483308863	0.508468936756082	0.8652668498473	0.957561780280432	0.981385051711174	0.588457664972923	0.554929196121153	NA	NA	0.571270308322826	0.467603358401639	0.598920748239898	0.677239895145077	0.669514612772999	0.594596576392482	0.576927059824285	NA	NA	0.603244920087315	0.576823041378023	NA	NA	p.Tyr187Cys	1	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.125	-5.274	4.149	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187D	187	Y	D	missense	possibly_low	0.704249625892602	0.36589237012634	6	0.149374934597849	0.411480133887791	0.997019117897413	0.857181335931324	1.34597551430375	0.740900870337358	0.427522200851737	NA	NA	0.46220273051832	0.39171510341312	0.610509518206827	0.655858983981229	0.74834336185364	0.640209870535186	0.534729369604562	NA	NA	0.580809165878468	0.559755660721211	NA	NA	p.Tyr187Asp	1	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.125	-3.249	2.124	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187E	187	Y	E	missense	low	0.61876125826733	0.0819432859662974	6	0.0334532064107324	0.55319417853491	0.68432833799975	0.576981425881892	0.676970219550353	0.735779542562207	0.524581343897517	NA	NA	0.649652599875483	0.54860241783653	0.599936645529723	0.596176747827249	0.603696543232198	0.63867749242984	0.566875733645067	NA	NA	0.619368555204193	0.595039849505027	NA	NA	p.Tyr187Glu	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.125	-3.945	2.82	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187F	187	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr187Phe	1	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.125	-2.312	1.187	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187G	187	Y	G	missense	possibly_wt-like	0.777708823328845	0.0918466391561658	6	0.037496233420356	0.70421755626904	0.85120009038865	0.889632397172611	0.876994504631252	0.673178204914548	0.770461520283252	NA	NA	0.68399301966237	0.77199329330904	0.646112467639253	0.662771020106109	0.646944147863855	0.619946233000972	0.648312200240609	NA	NA	0.626432553811994	0.64528078741465	NA	NA	p.Tyr187Gly	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.125	-3.878	2.753	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187H	187	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr187His	1	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.125	-2.687	1.562	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187I	187	Y	I	missense	possibly_wt-like	0.817032494939133	0.256039796778068	6	0.104527809325361	0.612161753278555	1.02190323659971	1.14417615496171	1.10390501709449	0.525829984231849	0.727680000675369	NA	NA	0.604311702915665	0.796292109755716	0.642444211202137	0.716988527389429	0.696004871294553	0.575857434714841	0.634142795274068	NA	NA	0.610041702620903	0.650745627130205	NA	NA	p.Tyr187Ile	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.125	-3.911	2.786	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187K	187	Y	K	missense	possibly_low	0.615350771798602	0.258591873853345	6	0.105569690428475	0.408437980699748	0.822263562897456	0.794850142375093	1.05943737956749	0.491093386750352	0.509374557929452	NA	NA	0.397675248381035	0.439673915788189	0.569038601918726	0.642582516430165	0.686390444696834	0.56546372359697	0.561839187243819	NA	NA	0.567535535363423	0.570541668474028	NA	NA	p.Tyr187Lys	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.125	-3.978	2.853	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187L	187	Y	L	missense	possibly_wt-like	0.736454392468176	0.153824136977536	6	0.062798440953158	0.613371709914721	0.85953707502163	0.782955296400269	0.994707838960845	0.582802898250193	0.700666742715043	NA	NA	0.584155854856227	0.773437723626476	0.632622414249033	0.640048928869914	0.672395156179678	0.592904585350864	0.625195899628151	NA	NA	0.605895542395882	0.645605641926901	NA	NA	p.Tyr187Leu	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.125	-2.718	1.593	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187M	187	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr187Met	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.125	-4.823	3.698	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187N	187	Y	N	missense	wt-like	1.57810317676399	0.254346505383133	4	0.127173252691566	1.3288481816917	1.82735817183627	NA	NA	1.3049173946738	1.49785688436818	NA	NA	1.59583905835131	1.91379936966265	0.851616136369376	NA	NA	0.808972076527904	0.88922836168066	NA	NA	0.814003911058092	0.902074660779324	NA	NA	p.Tyr187Asn	1	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.125	-3.083	1.958	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187P	187	Y	P	missense	possibly_low	0.649570493571333	0.218765896839734	6	0.089310803396615	0.47452453548363	0.824616451659036	0.75785544797401	1.01616414143906	0.637263226665483	0.455921477025016	NA	NA	0.613509122998801	0.416709545325626	0.610566795640907	0.634702692031577	0.677034261306637	0.609199932678258	0.544135319849996	NA	NA	0.611933658603556	0.56537694763168	NA	NA	p.Tyr187Pro	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.125	-4.436	3.311	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187Q	187	Y	Q	missense	low	0.347042357188745	0.307564550921225	6	0.125562702120876	0.100943983230297	0.593140731147193	0.452897102330426	0.901395018495397	0.0849851203432481	0.354962150438275	NA	NA	0.103482452095613	0.18453229942951	0.511928570975419	0.56974693955251	0.652219826144515	0.443950037466279	0.510697199917175	NA	NA	0.507018584310345	0.513159942033664	NA	NA	p.Tyr187Gln	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.125	-4.301	3.176	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187R	187	Y	R	missense	possibly_low	0.648810104406483	0.22468796077596	6	0.0917284758745971	0.469025595335521	0.828594613477444	0.80180159457801	1.00777018137642	0.618743178457194	0.593974960181575	NA	NA	0.485624784589293	0.384945927256407	0.596758812242852	0.644063167198092	0.675219388347904	0.603658456398996	0.589859168086708	NA	NA	0.585627201254156	0.558233263003447	NA	NA	p.Tyr187Arg	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.125	-3.133	2.008	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187S	187	Y	S	missense	wt-like	0.839499602461079	0.101558819104245	6	0.0414612142808366	0.758237115715341	0.920762089206816	0.936607286939356	0.898837331421135	0.858779024202546	0.913420536475256	NA	NA	0.686193436803671	0.74315999892451	0.662221718968356	0.672776613840495	0.651666824096217	0.675480782691602	0.695660780015448	NA	NA	0.626885190783795	0.638796136912077	NA	NA	p.Tyr187Ser	1	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.125	-3.879	2.754	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187T	187	Y	T	missense	possibly_low	0.690897913549951	0.179950488640088	6	0.0734644793554529	0.546910179870277	0.834885647229625	0.518121208133664	0.909246555802769	0.714402551289954	0.44745065009915	NA	NA	0.709667742003275	0.846498773970893	0.631997575202527	0.583639593853485	0.653917420919483	0.632281175923268	0.541329749168679	NA	NA	0.631713974481786	0.662037180082619	NA	NA	p.Tyr187Thr	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.125	-3.371	2.246	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187V	187	Y	V	missense	possibly_low	0.486233921132195	0.342041859863701	6	0.139638004556436	0.212548461328541	0.759919380935849	0.819642106784924	0.951597188293789	0.319224419096704	0.527794074056846	NA	NA	0.17123427577258	0.127911462788327	0.544447640278483	0.647863174351745	0.663074126112212	0.51403794993361	0.567939802315208	NA	NA	0.520955478241758	0.500425832226969	NA	NA	p.Tyr187Val	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.125	-3.081	1.956	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187W	187	Y	W	missense	possibly_low	0.676424150412106	0.150976723187486	6	0.0616359891411272	0.555619831543995	0.797228469280217	0.655988957199741	0.976814093538752	0.6497882524016	0.616390325956518	NA	NA	0.592530315236871	0.567032958139153	0.61028290984126	0.613005254807223	0.66852631781797	0.612947608290829	0.597283224035383	NA	NA	0.607618211391692	0.599184905246567	NA	NA	p.Tyr187Trp	0	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.125	-4.924	3.799	0.004190037	NA	NA	NA	NA	NA	NA	NA
Y187X	187	Y	X	nonsense	low	-0.0161974277857222	0.174381679225703	6	0.0711910224321112	-0.155729267775243	0.123334412203799	-0.0473086932108666	-0.290792299705777	0.0053980774234857	0.250310970331162	NA	NA	0.037473413389662	-0.052266034941999	0.461553683619356	0.463203720427927	0.39445489643317	0.420136400184325	0.47603632380162	NA	NA	0.493440190091089	0.459903646810786	NA	NA	p.Tyr187Ter	1	38.4	3	15.3	0.946	68.3	-77	-157	171.2	5.49019607843137	-0.9	0	0	15.82	1	9	0	0	4	19.9585411019281	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D188A	188	D	A	missense	possibly_wt-like	0.754145963811055	0.110751633540814	6	0.0452141650591177	0.665527828704135	0.842764098917975	0.619876184341436	0.780861767951151	0.61648316242305	0.882340166363815	NA	NA	0.799323611031863	0.825990890755013	0.638157880223114	0.605313278612354	0.626159118753922	0.602982225694674	0.685366841075097	NA	NA	0.650156641692306	0.657424926851024	NA	NA	p.Asp188Ala	1	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.495	-2.724	1.229	0.007977655	NA	NA	NA	NA	1.23e-05	NA	NA
D188C	188	D	C	missense	wt-like	0.931094983217332	0.18935381741424	4	0.0946769087071198	0.74553165198379	1.11665831445087	1.08337318503605	0.739173801546217	NA	NA	NA	NA	1.10381583687514	0.798017109411912	0.677585575846485	0.704037569591741	0.61714568976829	NA	NA	NA	NA	0.712792237669045	0.651133582101229	NA	NA	p.Asp188Cys	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.495	-5.538	4.043	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188E	188	D	E	missense	possibly_wt-like	0.821367734625336	0.132732559693827	6	0.0541878405838974	0.715161518680899	0.927573950569773	0.914717258812563	1.04782024973262	0.773411086481334	0.726117965299865	NA	NA	0.709306282700415	0.756833564725221	0.645904378507616	0.668114064777399	0.683878684498065	0.649937414954584	0.633625443108684	NA	NA	0.631639620468992	0.641871342060647	NA	NA	p.Asp188Glu	1	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.495	-2.234	0.739	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188F	188	D	F	missense	possibly_low	0.665272729572178	0.214344024804942	6	0.0875055816977613	0.493764940998339	0.836780518146018	0.951140239292669	0.89479593957739	0.484172972154245	0.675147315433974	NA	NA	0.5331654226317	0.45321448834309	0.606075159114319	0.675872114814111	0.650793027614209	0.563393031723186	0.616743766488098	NA	NA	0.595406551740539	0.573586963245145	NA	NA	p.Asp188Phe	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.495	-4.792	3.297	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188G	188	D	G	missense	possibly_low	0.697300811716234	0.173520081855863	6	0.0708392767788058	0.55845838053891	0.836143242893558	0.788210420930842	0.980551490649994	0.739281730394699	0.541320862917421	NA	NA	0.599750997498431	0.534689367906019	0.62441447097306	0.64116826393036	0.669334387060927	0.639725399572468	0.572419927168628	NA	NA	0.609103542373653	0.591910784021875	NA	NA	p.Asp188Gly	1	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.495	-2.964	1.469	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188H	188	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp188His	1	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.495	-4.061	2.566	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188I	188	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp188Ile	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.495	-4.399	2.904	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188K	188	D	K	missense	wt-like	0.848863229543075	0.0748096739051667	6	0.0305409214819434	0.7890041233838	0.908722335702349	0.916786380614233	0.811674601694559	0.762252580289884	0.951324822981738	NA	NA	0.863655942373295	0.787485049304739	0.656077517461228	0.668554785175835	0.632821216062641	0.646598622491601	0.708214826491608	NA	NA	0.663390128698367	0.648764906224089	NA	NA	p.Asp188Lys	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.495	-3.179	1.684	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188L	188	D	L	missense	possibly_low	0.608872107855334	0.187323959946101	6	0.076474686410917	0.458984476760942	0.758759738949726	0.609415175564788	0.970864079466887	0.567639107027642	0.435680104038843	NA	NA	0.505245772601809	0.564388408432037	0.594126740082029	0.603085096611487	0.667239854746604	0.588367351515487	0.537431298731798	NA	NA	0.589663338053421	0.598590142110637	NA	NA	p.Asp188Leu	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.495	-3.416	1.921	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188M	188	D	M	missense	wt-like	0.849088886275728	0.128287918255478	6	0.0523733233149667	0.746439058827722	0.951738713723735	0.816790792399594	1.10429904586263	0.829330283043718	0.8099286962424	NA	NA	0.786363184623156	0.747821315482875	0.654437248984617	0.647255847895201	0.696090064951767	0.666669277518914	0.661383881755817	NA	NA	0.647490616213416	0.639844473892227	NA	NA	p.Asp188Met	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.495	-5.19	3.695	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188N	188	D	N	missense	wt-like	0.953939726098749	0.286916924043954	6	0.117133343746094	0.724362590967655	1.18351686122984	0.561608172107662	0.820888358276826	0.783333544752448	1.04011272158217	NA	NA	1.35241538897752	1.16528017089587	0.693318975261488	0.592902263684671	0.634813338677557	0.652906363335438	0.737621722341232	NA	NA	0.7639304270345	0.733731587187537	NA	NA	p.Asp188Asn	1	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.495	-2.541	1.046	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188P	188	D	P	missense	possibly_low	0.711560400053827	0.171592534885997	6	0.0700523590235691	0.574260299335562	0.848860500772092	0.533588984502112	0.918624864028737	0.89137466541655	0.770986190010461	NA	NA	0.597450659075005	0.557337037290096	0.628558161986566	0.586934211192355	0.655945121536468	0.685233887573581	0.648485972886056	NA	NA	0.608630351087076	0.597004278323808	NA	NA	p.Asp188Pro	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.495	-2.146	0.651	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188Q	188	D	Q	missense	possibly_low	0.714250197360515	0.148382848694869	6	0.0605770443138384	0.595521372215505	0.832979022505525	0.771753080656866	0.927540640824442	0.771217014368976	0.679458103171114	NA	NA	0.651184117217873	0.484348227923818	0.628673233395001	0.63766287069692	0.65787281741444	0.649280915661014	0.618171516080262	NA	NA	0.619683596093082	0.580588987270795	NA	NA	p.Asp188Gln	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.495	-3.078	1.583	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188R	188	D	R	missense	possibly_low	0.639151888198135	0.132816842335453	6	0.0542222488282572	0.532878233333982	0.745425543062288	0.721204751993757	0.853886404818628	0.564531096614917	0.643852715524463	NA	NA	0.480811552639586	0.570624807597459	0.603185795652502	0.626896138873457	0.641947904712275	0.587437388170677	0.606378873809016	NA	NA	0.584637095017751	0.599992717495987	NA	NA	p.Asp188Arg	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.495	-3.518	2.023	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188S	188	D	S	missense	low	0.597500546958728	0.132877494581346	6	0.0542470100039557	0.49117836108199	0.703822732835465	0.574256178246316	0.738751606334796	0.717865649282338	0.669277082589744	NA	NA	0.447639758832891	0.437213006466281	0.6051978980354	0.595596273433321	0.61705440619453	0.633317386799272	0.614799522637478	NA	NA	0.577813488704172	0.569988206332024	NA	NA	p.Asp188Ser	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.495	-3	1.505	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188T	188	D	T	missense	possibly_low	0.675595126865179	0.161059812834183	6	0.0657523932519851	0.546722804193974	0.804467449536385	0.839748404919179	0.781401669414866	0.700289713701729	0.772530892458308	NA	NA	0.430392569605628	0.529207511091368	0.627167127493732	0.652145791120677	0.626275851804778	0.628058403182686	0.648997584318678	NA	NA	0.57426565436068	0.5906779063259	NA	NA	p.Asp188Thr	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.495	-3.197	1.702	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188V	188	D	V	missense	low	0.481554286883025	0.230547974127451	6	0.0941208163074387	0.297080876724935	0.666027697041115	0.723677248308231	0.78419559531282	0.213455267829908	0.307597673191991	NA	NA	0.493973130085777	0.366426806569425	0.57070639184419	0.627422777546911	0.626879931467185	0.482390233025382	0.495009901633188	NA	NA	0.587344498285775	0.554068285402605	NA	NA	p.Asp188Val	1	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.495	-3.435	1.94	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188W	188	D	W	missense	possibly_low	0.620258458899415	0.147554204001746	6	0.060238751534469	0.502192675418199	0.738324242380631	0.617954968449601	0.894816243876041	0.454380176270926	0.547645038022577	NA	NA	0.610981846747146	0.595772480030198	0.605276264083796	0.604904061990768	0.65079741764255	0.554478580215095	0.574514518453968	NA	NA	0.611413785054135	0.605648466176825	NA	NA	p.Asp188Trp	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.495	-5.94	4.445	0.007977655	NA	NA	NA	NA	NA	NA	NA
D188X	188	D	X	nonsense	low	-0.0423238221465539	0.0726168231769349	6	0.0296456939209003	-0.100428314528217	0.0157806702351087	0.00184853414165696	-0.026835986378752	-0.0473395398220078	0.0571177008222387	NA	NA	-0.15393504120501	-0.0847986004374495	0.452056191396849	0.473674149383491	0.451525358023271	0.404356513884681	0.412049964794926	NA	NA	0.454066499694493	0.452587024770426	NA	NA	p.Asp188Ter	0	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D188Y	188	D	Y	missense	possibly_low	0.667557018854412	0.291904425570523	6	0.119169482718002	0.43398912467086	0.901124913037964	0.885629243686007	1.16434596911397	0.52888703721126	0.472254629776389	NA	NA	0.50690929735364	0.447315935985204	0.583388842183692	0.661918353337922	0.709072916484377	0.576772150831091	0.549544923291757	NA	NA	0.590005533536292	0.572260370105911	NA	NA	p.Asp188Tyr	1	39.7	0.7	12.5	0.653	37.7	-155.4	-81.3	112.7	40.6417112299465	-3.2	0	0	16.72	1	2	0	0	5	22.1067480279642	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.495	-4.762	3.267	0.007977655	NA	NA	NA	NA	NA	NA	NA
P189A	189	P	A	missense	wt-like	1.11245412052961	0.277001219384026	6	0.113085274269934	0.890811055778701	1.33409718528051	1.02849900390539	0.759580720919049	0.882381172114855	1.1547907499159	NA	NA	1.390723956391	1.45874911993144	0.732080065129623	0.692349436514116	0.621557905917091	0.682542899448791	0.77560352941864	NA	NA	0.77181069374513	0.799733187367991	NA	NA	p.Pro189Ala	1	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.992	-2.817	0.825	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189C	189	P	C	missense	possibly_low	0.713198144127826	0.213530003498948	6	0.087173258891188	0.542341696286112	0.884054591969541	0.767150968994908	0.909572064874672	0.625620376562824	0.820558898565915	NA	NA	0.32238376471483	0.833902791053807	0.645335213193057	0.636682626574188	0.653987799811926	0.605716217250454	0.664904645931065	NA	NA	0.552047695112839	0.659204324916492	NA	NA	p.Pro189Cys	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.992	-5.515	3.523	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189D	189	P	D	missense	low	0.129869007059161	0.619211944275007	6	0.252792217685076	-0.365594635175598	0.62533264929392	0.764075160516089	1.06558119393651	-0.150750039668965	-0.311048603374084	NA	NA	-0.350496958747665	-0.238146710306914	0.41586576206897	0.636027483151891	0.687718809673386	0.373414540867997	0.290111859112702	NA	NA	0.413632715818672	0.418098808319267	NA	NA	p.Pro189Asp	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.992	-2.601	0.609	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189E	189	P	E	missense	possibly_wt-like	0.76443496252372	0.25150585642523	6	0.10267683592725	0.563192062059782	0.965677862987658	0.921347766639136	0.998104934128531	0.353085678138067	0.687448514188624	NA	NA	0.644285218113493	0.98233766393447	0.645172162970141	0.669526354787973	0.673129648137235	0.524169746657535	0.62081797115231	NA	NA	0.618264457539414	0.692587547110532	NA	NA	p.Pro189Glu	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.992	-2.555	0.563	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189F	189	P	F	missense	possibly_wt-like	0.812772644035326	0.131202733898423	6	0.0535632918182163	0.707790521178213	0.917754766892439	0.998692734285036	0.657938025354388	0.730332307218754	0.926965446123043	NA	NA	0.727874523250418	0.834832827980315	0.648230544742846	0.686000737751016	0.599581558846542	0.637047597890484	0.700146906543766	NA	NA	0.635459201773139	0.659413491595209	NA	NA	p.Pro189Phe	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.992	-4.67	2.678	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189G	189	P	G	missense	possibly_wt-like	0.77901176934105	0.0749828741048384	6	0.0306116301673674	0.71901407670495	0.83900946197715	0.764058684133953	0.927087675942887	0.744754751261006	0.714599794103399	NA	NA	0.766586375666437	0.756983334938617	0.641634017565008	0.636023973702764	0.657774881075852	0.64136300952712	0.629810580204034	NA	NA	0.643422426255227	0.641905025602896	NA	NA	p.Pro189Gly	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.992	-2.999	1.007	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189H	189	P	H	missense	wt-like	1.05682887759216	0.16785130518234	2	0.118688796125445	0.824203111817868	1.28945464336645	0.938140081466713	1.1755176737176	NA	NA	NA	NA	NA	NA	0.692295733847478	0.673103097189263	0.711488370505693	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro189His	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.992	-3.234	1.242	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189I	189	P	I	missense	possibly_low	0.707273986284189	0.193998125178422	6	0.0791994029572851	0.552046008890835	0.862501963677543	0.799744703675012	1.04321073895696	0.572456050010468	0.525815947748932	NA	NA	0.719700558257072	0.582715919056693	0.618244901010645	0.643625051966027	0.682882054016469	0.5898086531243	0.567284639221688	NA	NA	0.633777775695894	0.602712026325396	NA	NA	p.Pro189Ile	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.992	-3.755	1.763	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189K	189	P	K	missense	low	0.559852571887547	0.126348208854525	6	0.051581440268031	0.458754806691502	0.660950337083592	0.533023186742298	0.716142894600937	0.669979217544876	0.600013121797875	NA	NA	0.389956749264343	0.450000261374952	0.589336363781236	0.586813696965528	0.612166136623155	0.618989047985722	0.591859030596945	NA	NA	0.56594780092823	0.572864078851625	NA	NA	p.Pro189Lys	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.992	-2.911	0.919	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189L	189	P	L	missense	possibly_low	0.638974986038784	0.141031727227508	6	0.057575961541796	0.526128175041601	0.751821797035968	0.64320040648239	0.917244769194104	0.574181887934972	0.587521304779181	NA	NA	0.581666639887398	0.53003490795466	0.598123743674123	0.6102813092362	0.655646728790116	0.59032504972397	0.587721692425507	NA	NA	0.605383498245477	0.590863989102769	NA	NA	p.Pro189Leu	1	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.992	-3.195	1.203	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189M	189	P	M	missense	wt-like	0.93400539019941	0.215546458999133	6	0.0879964734019351	0.76153547156508	1.10647530883374	1.05185275158542	1.26455494839114	0.736523206114742	1.02623593744931	NA	NA	0.725214880016795	0.799650617639048	0.67441235827808	0.697323756041463	0.730739277219365	0.638900007721905	0.733025677698266	NA	NA	0.634912099663841	0.651500960514697	NA	NA	p.Pro189Met	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.992	-5.012	3.02	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189N	189	P	N	missense	low	-0.187982091529191	0.447881971715647	5	0.200298906930565	-0.580560735255838	0.204596552197457	-0.134767833804613	0.548968022526367	-0.41050175698161	-0.320409998467453	NA	NA	NA	-0.623198890918644	0.331500004061215	0.444575031068892	0.576020961706495	0.295692930006237	0.287011328805562	NA	NA	NA	0.331500004061215	NA	NA	p.Pro189Asn	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.992	-3.143	1.151	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189P	189	P	P	synonymous	possibly_wt-like	0.85332898887088	0.185981611887242	6	0.0759266751106803	0.704515440188073	1.00214253755369	0.832186518695181	0.977997429862855	0.875931634910297	1.0828711316426	NA	NA	0.533181880740074	0.817805337374279	0.662183076430872	0.650535118657183	0.668782169058585	0.680613101155108	0.751783473336162	NA	NA	0.595409937256947	0.65558398380316	NA	NA	p.Pro189=	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189Q	189	P	Q	missense	possibly_wt-like	0.933232676562907	0.296501593431859	4	0.14825079671593	0.642666454320316	1.2237988988055	NA	NA	NA	NA	0.862242968056041	0.550334409066361	1.22756292198002	1.09279040714921	0.674743751897289	NA	NA	NA	NA	0.632058971562959	0.585749196470881	0.738247641019531	0.717428532231618	NA	NA	p.Pro189Gln	1	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.992	-1.777	-0.215	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189R	189	P	R	missense	possibly_low	0.607298332223832	0.208965307540543	6	0.085309729569682	0.440094334736404	0.774502329711261	0.742228170926006	0.966609580674732	0.523181052915929	0.471166717257405	NA	NA	0.407538910540944	0.533065561027978	0.583305211089743	0.63137410124417	0.666319982034176	0.575064834723336	0.549184602452504	NA	NA	0.56956454072206	0.59154558745615	NA	NA	p.Pro189Arg	1	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.992	-3.629	1.637	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189S	189	P	S	missense	wt-like	0.9259360265554	0.0697754918332446	6	0.0284857252571973	0.87010503097779	0.98176702213301	0.826489956914643	1.00040959856995	0.893180448963337	0.971234595800659	NA	NA	0.87874137934479	0.985560179739021	0.679701074408604	0.649321758005526	0.673627943714349	0.685774205102859	0.714809020350283	NA	NA	0.666493279633213	0.693312295675606	NA	NA	p.Pro189Ser	1	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.992	-3.021	1.029	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189T	189	P	T	missense	wt-like	0.997719747390713	0.17994604808485	6	0.0734626665063679	0.853735566829955	1.14170392795147	0.843136457480286	0.7702535782075	1.01807229780671	0.951225656414741	NA	NA	1.21560249787044	1.1880279965646	0.715662851081727	0.652867442148397	0.623865503277653	0.723143720022859	0.708181982140594	NA	NA	0.735787321088001	0.73884760678585	NA	NA	p.Pro189Thr	1	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.992	-3.501	1.509	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189V	189	P	V	missense	possibly_wt-like	0.780261118381916	0.120771653989123	6	0.0493048212775529	0.683625444413728	0.876896792350103	0.86025818755798	0.897335947531675	0.698422867118305	0.575402325745839	NA	NA	0.816648796826104	0.833498585511591	0.652531363777053	0.656514349592733	0.651342207228693	0.627499814676721	0.583707839638642	NA	NA	0.653720520325413	0.659113418492913	NA	NA	p.Pro189Val	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.992	-3.115	1.123	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189W	189	P	W	missense	wt-like	0.912295362507158	0.0523951864363508	6	0.0213902452911756	0.870371252115976	0.95421947289834	0.876101886112531	0.898270314617283	0.890682920660936	0.858307271575767	NA	NA	0.953727240541878	0.996682541534554	0.679662652522204	0.659889037894804	0.651544228389688	0.68502690716449	0.677407053253363	NA	NA	0.681918251791044	0.695813731274512	NA	NA	p.Pro189Trp	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.992	-5.768	3.776	0.006510239	NA	NA	NA	NA	NA	NA	NA
P189X	189	P	X	nonsense	low	-0.233914671246205	0.330825759441711	6	0.135059050733488	-0.498625546470009	0.0307962039775986	-0.22741390088369	0.312942593871126	-0.132260350969711	-0.262186911798595	NA	NA	-0.404808799820939	-0.689760657875423	0.3907037138178	0.424841532749155	0.524989486116565	0.378946933126674	0.306295040580518	NA	NA	0.402460494508926	0.316530164340784	NA	NA	p.Pro189Ter	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P189Y	189	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro189Tyr	0	37.2	1.1	9.6	0.58	87.9	65.8	-71.4	-7.5	13.6363636363636	-0.3	0	0	17.14	0	0	0	0	5	20.1412791687549	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.992	-3.466	1.474	0.006510239	NA	NA	NA	NA	NA	NA	NA
T190A	190	T	A	missense	wt-like	0.884943634745896	0.0950911207406572	6	0.0388207874806661	0.808856289432307	0.961030980059485	1.03492206029551	0.880851908913957	0.930283990808814	0.768070922561197	NA	NA	0.893712479754843	0.801820446141054	0.660780934553736	0.693717539623919	0.647778164069715	0.696876141485579	0.64752042501742	NA	NA	0.66957291095718	0.651988958150291	NA	NA	p.Thr190Ala	1	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.345	-2.323	-0.022	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190C	190	T	C	missense	wt-like	1.02691519767334	0.0762031121145175	6	0.0311097902487779	0.965941129219144	1.08788926612754	1.11379576910019	1.07406167691348	0.945832681442055	0.934655776041387	NA	NA	1.00531405557344	1.08783122696951	0.70211125829648	0.710517542573209	0.689552389904534	0.70152854299926	0.7026939735937	NA	NA	0.69252992141609	0.716313205282996	NA	NA	p.Thr190Cys	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.345	-5.516	3.171	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190D	190	T	D	missense	possibly_low	0.590757348354411	0.365393977932136	6	0.149171466836585	0.298386645833693	0.883128050875129	0.660959944177534	1.13220116341082	-0.00437342833182299	0.599875206970492	NA	NA	0.491680322734716	0.664200881164723	0.602938710795247	0.614064068918457	0.702122831161242	0.417212619060932	0.591813352672037	NA	NA	0.586872856179	0.621038114681414	NA	NA	p.Thr190Asp	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.345	-2.697	0.352	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190E	190	T	E	missense	wt-like	1.10282535131205	0.19736923274569	6	0.0805756518585922	0.944899975638375	1.26075072698573	1.19356739181101	1.35125863470085	1.01748357512965	0.967858386135311	NA	NA	1.25816627089702	0.828617849198474	0.725238182722624	0.727508800079943	0.749485634663477	0.722967565365306	0.713690806634672	NA	NA	0.744542905185937	0.65801573368577	NA	NA	p.Thr190Glu	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.345	-2.39	0.045	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190F	190	T	F	missense	wt-like	1.3076223230222	0.262802792273411	6	0.10728879067475	1.09734015735483	1.51790448868957	0.880995733488247	1.23606690457941	1.37320135443418	1.20520558447239	NA	NA	1.5870331858072	1.56323117535177	0.802246808123719	0.660931421365689	0.724579826855621	0.82940366174899	0.792301117856345	NA	NA	0.812192498391093	0.823231355983606	NA	NA	p.Thr190Phe	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.345	-4.774	2.429	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190G	190	T	G	missense	wt-like	0.948072928229438	0.173376165316585	6	0.070780523097676	0.809345652151088	1.08680020430779	0.734433156217632	0.756149245595479	1.04196692457031	0.938017487144337	NA	NA	1.1687232172831	1.04914753856577	0.705710285971397	0.629713772700286	0.620815980565192	0.730293350840399	0.703807385329299	NA	NA	0.726144015186128	0.707613186613494	NA	NA	p.Thr190Gly	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.345	-2.627	0.282	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190H	190	T	H	missense	wt-like	1.2643033575602	0.185236097143725	5	0.0828401010200247	1.10193974308529	1.42666697203511	1.4847922320913	1.42914483121717	1.09443716507029	NA	NA	NA	1.22510837537612	1.08803418404613	0.745993234006343	0.789539332810831	0.766325547036314	0.745993234006343	NA	NA	NA	0.737742728327713	0.716358850629357	NA	NA	p.Thr190His	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.345	-3.366	1.021	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190I	190	T	I	missense	wt-like	1.06780864132166	0.103794072719514	6	0.0423737527480234	0.984757612045728	1.15085967059759	0.978463555692241	0.92995803531033	1.20410962376288	1.15722973960638	NA	NA	1.05618548405163	1.08090540950649	0.708875005550487	0.681691947595576	0.65839548655395	0.778808879057494	0.776411332249171	NA	NA	0.702994432396937	0.714755578704038	NA	NA	p.Thr190Ile	1	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.345	-4.384	2.039	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190K	190	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr190Lys	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.345	-2.983	0.638	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190L	190	T	L	missense	wt-like	1.16239040508157	0.143781061303974	6	0.0586983724784273	1.04734370907273	1.2774371010904	1.09550243011302	0.905763016511764	1.20993995249173	1.30301909500036	NA	NA	1.19974483421844	1.2603731021541	0.743821723557447	0.706621083872403	0.653164238725054	0.78055340088529	0.824697331328256	NA	NA	0.732525319206373	0.755118127908522	NA	NA	p.Thr190Leu	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.345	-3.061	0.716	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190M	190	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr190Met	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.345	-4.349	2.004	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190N	190	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr190Asn	1	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.345	-2.676	0.331	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190P	190	T	P	missense	possibly_wt-like	1.06082138534178	0.409617692365024	5	0.183186600982958	0.701782244964872	1.41986052571869	NA	0.618945783478827	1.00796944254722	0.716130477021459	NA	NA	1.51196107743614	1.44910014622525	0.720120794156595	NA	0.591150977231643	0.720120794156595	0.6303175483141	NA	NA	0.796749784751921	0.797563118927019	NA	NA	p.Thr190Pro	1	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.345	-3.451	1.106	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190Q	190	T	Q	missense	possibly_wt-like	0.961851315468367	0.314382281604141	5	0.140596030517668	0.686288159284443	1.23741447165229	0.918093303757338	1.08793885877975	1.08579463500034	0.445861494151626	NA	NA	1.27156828565278	NA	0.6925527999523	0.668833158197611	0.6925527999523	0.743407259345976	0.540803414564817	NA	NA	0.747299767628619	NA	NA	NA	p.Thr190Gln	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.345	-2.746	0.401	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190R	190	T	R	missense	wt-like	1.13931506220447	0.189556612098267	6	0.0773861628352391	0.987640970145653	1.29098915426329	0.909473273220489	0.92564595164881	1.28581805738567	1.37893940834119	NA	NA	1.15001492721132	1.18599875541936	0.730343426219583	0.666997102297151	0.657463163315016	0.803257268264909	0.849842433109885	NA	NA	0.722295624984683	0.738391227454484	NA	NA	p.Thr190Arg	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.345	-3.102	0.757	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190S	190	T	S	missense	wt-like	1.14073691963884	0.125702315795351	6	0.0513177555308007	1.04015596703104	1.24131787224664	0.983408652118647	1.00222980427265	1.13178537266527	1.22320077729069	NA	NA	1.29358037018745	1.21021654129837	0.74783280419579	0.682745247051214	0.674021493610286	0.757168378052022	0.79826119540456	NA	NA	0.751827765115914	0.743837843275665	NA	NA	p.Thr190Ser	1	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.345	-2.121	-0.224	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190V	190	T	V	missense	wt-like	1.02793075075291	0.128900113605319	6	0.0526232510199693	0.924791074004361	1.13107042750146	0.911237864796532	0.953592207950004	1.15222422918363	1.12815188374336	NA	NA	0.873568227475645	1.1488100913683	0.698700200051323	0.667372958132144	0.663505472842383	0.763283990565443	0.766780633782679	NA	NA	0.665429136042996	0.730027441970501	NA	NA	p.Thr190Val	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.345	-3.218	0.873	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190W	190	T	W	missense	wt-like	1.06031178321983	0.217900081993739	6	0.0889573359658796	0.885958608566074	1.23466495787358	0.782833080250256	0.891892066378945	1.12711271767489	1.02591241711855	NA	NA	1.12404431345499	1.41007610444133	0.72493593223057	0.640022896980305	0.650165176051405	0.755770249575297	0.732918526511878	NA	NA	0.716953337949261	0.788786554279508	NA	NA	p.Thr190Trp	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.345	-5.916	3.571	0.008592702	NA	NA	NA	NA	NA	NA	NA
T190X	190	T	X	nonsense	low	-0.126037545134228	0.285136559493591	6	0.116406512962006	-0.354190118105655	0.102115027837199	0.107669413619149	0.119020510517435	-0.0793402690794844	0.0608028724768435	NA	NA	-0.505257745945491	-0.459120052393822	0.404025961751686	0.49621386653716	0.483061249318539	0.394781415585529	0.413270507917842	NA	NA	0.381797636571184	0.368401577239494	NA	NA	p.Thr190Ter	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T190Y	190	T	Y	missense	wt-like	0.946938432947603	0.116168375064729	6	0.0474255405261404	0.853986081569023	1.03989078432618	0.962660128552893	0.95225324516979	0.913902346787015	0.752519010935684	NA	NA	1.10933129813199	0.990964568108252	0.685150172438343	0.678325837055403	0.663215973330302	0.691974507821283	0.642369571661918	NA	NA	0.713926796037332	0.694527750603761	NA	NA	p.Thr190Tyr	0	38.1	-2.3	8.1	0.616	100.6	52.1	-84.1	-10.5	63.8036809815951	-0.3	0	0	19.19	0	0	0	0	5	23.0055981173178	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.345	-4.127	1.782	0.008592702	NA	NA	NA	NA	NA	NA	NA
K191A	191	K	A	missense	wt-like	0.910592014250147	0.122187514763338	6	0.0498828440181609	0.812823436528122	1.00836059197217	0.968454175151491	1.09317780483848	0.80455523572885	0.9219629874355	NA	NA	0.927043060949773	0.748358821396787	0.677994571247829	0.679559961853386	0.69368552175027	0.659256211663529	0.698490072854317	NA	NA	0.676429180642272	0.639965359766324	NA	NA	p.Lys191Ala	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.249	-2.661	0.412	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191C	191	K	C	missense	wt-like	1.00373011372766	0.0587561865801563	6	0.0239871127255246	0.956716236692532	1.05074399076279	0.980872716016766	1.0350858188325	0.967538282956509	0.917587916989268	NA	NA	1.07717362315049	1.04412232442044	0.701762020554207	0.682205095781083	0.681125350658853	0.708023184620421	0.697041032579965	NA	NA	0.707311799112159	0.706483008528449	NA	NA	p.Lys191Cys	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.249	-3.76	1.511	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191D	191	K	D	missense	wt-like	1.11342067299195	0.320640936230202	6	0.130901114068712	0.856859203881101	1.36998214210279	0.524993945679376	0.992787061746839	1.17396701590655	1.3590755566778	NA	NA	1.37846883785412	1.251231620087	0.761175974380699	0.585103478496257	0.671979861539313	0.769789758558863	0.84326344851575	NA	NA	0.769289753674502	0.753062195086897	NA	NA	p.Lys191Asp	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.249	-3.066	0.817	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191E	191	K	E	missense	low	0.53150941355858	0.188225353227792	6	0.0768426786772028	0.380900530875678	0.682118296241481	0.771980386469796	0.694493055653123	0.508515297773196	0.468485490400484	NA	NA	0.235186206604996	0.510396044449881	0.578561900221529	0.637711286555455	0.60748518663363	0.570676620755051	0.548296569734379	NA	NA	0.534110714932804	0.586447179688007	NA	NA	p.Lys191Glu	1	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.249	-2.243	-0.006	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191F	191	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys191Phe	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.249	-4.693	2.444	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191G	191	K	G	missense	possibly_wt-like	0.772078896067423	0.128946674922416	6	0.052642259598076	0.668901963190386	0.87525582894446	0.940398177047746	0.93143517849842	0.695550444505152	0.681459323556524	NA	NA	0.656762569400189	0.726867683396505	0.630886156908604	0.673584068770237	0.658714862296536	0.626640342736055	0.618834328021682	NA	NA	0.620831112014381	0.635131971081153	NA	NA	p.Lys191Gly	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.249	-3.258	1.009	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191H	191	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys191His	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.249	-3.858	1.609	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191I	191	K	I	missense	wt-like	1.0119499766958	0.15683936263395	6	0.0640294016727521	0.886454655465559	1.13744529792604	0.955516089405263	0.786643317138533	1.00242824323734	0.962442028237285	NA	NA	1.24730115570702	1.11736902644938	0.715179836056311	0.676804165505163	0.627409157734504	0.718462784188746	0.711896887923876	NA	NA	0.742307895857219	0.722956300022278	NA	NA	p.Lys191Ile	1	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.249	-3.127	0.878	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191K	191	K	K	synonymous	possibly_wt-like	0.736696365505023	0.26528516389071	6	0.108302214643808	0.524427925357232	0.948964805652813	0.804704571140464	0.314659597875375	0.926265016826187	1.04869829591074	NA	NA	0.551177559903042	0.774673151374324	0.645282494543652	0.644681497634812	0.525360722590659	0.695673604173514	0.740465297806687	NA	NA	0.599111739778365	0.645883491452493	NA	NA	p.Lys191=	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191L	191	K	L	missense	wt-like	1.00819740535082	0.0652154399081777	6	0.0266240918543623	0.956015144195189	1.06037966650646	1.06538145860911	0.96030414364815	0.96682578711361	1.11158477531088	NA	NA	0.953068290616423	0.992019976806783	0.697485233787227	0.700205353995235	0.66495667233683	0.707809995174687	0.761293543313336	NA	NA	0.681782702447591	0.694765113579219	NA	NA	p.Lys191Leu	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.249	-2.221	-0.028	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191M	191	K	M	missense	possibly_wt-like	0.812871777180756	0.200908894873377	6	0.08202071287104	0.652114133967217	0.973629420394295	0.774503278115427	0.778478790869559	0.727557687547257	0.679986222910747	NA	NA	1.21516029260178	0.701544391039762	0.632827057638629	0.638248659372452	0.625643891062297	0.636217390057294	0.618346431383184	NA	NA	0.735696357220304	0.629436725219964	NA	NA	p.Lys191Met	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.249	-3.127	0.878	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191N	191	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys191Asn	1	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.249	-3.4	1.151	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191P	191	K	P	missense	possibly_low	0.565967101780269	0.245067174547733	4	0.122533587273867	0.325805683826994	0.806128519733543	0.501678622090596	0.863973316933104	NA	NA	NA	NA	0.276017134773066	0.622199333324308	0.5958646238881	0.580137343253078	0.644128813829909	NA	NA	NA	NA	0.542509844050165	0.611591904523121	NA	NA	p.Lys191Pro	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.249	-3.584	1.335	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191Q	191	K	Q	missense	wt-like	0.959732533901496	0.183520088316866	6	0.0749217623211377	0.812888578093796	1.1065764897092	0.868646844100091	1.02646112305633	1.15439590171519	1.16514202309393	NA	NA	0.721970964602307	0.82177834684114	0.668780856520068	0.658301123116938	0.679260589923199	0.763933787568377	0.779031911180744	NA	NA	0.634244809802099	0.656477519501593	NA	NA	p.Lys191Gln	1	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.249	-2.409	0.16	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191R	191	K	R	missense	possibly_wt-like	0.822851084135054	0.188163555086874	6	0.0768174496918191	0.672291649354871	0.973410518915237	1.05829992774353	1.06596084842301	0.691747069309714	0.671038198902256	NA	NA	0.76450077693727	0.685559683494541	0.634417574446118	0.698696996632179	0.687800895441733	0.625502315815735	0.615382811180145	NA	NA	0.642993408013439	0.625841740878798	NA	NA	p.Lys191Arg	1	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.249	-2.943	0.694	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191S	191	K	S	missense	wt-like	1.02579877742346	0.164805751774281	6	0.067281666420462	0.893929134419512	1.1576684204274	1.28005319429819	1.09796038057448	1.03587583103269	1.00079526689287	NA	NA	0.778641531978173	0.961466459764321	0.709659600001794	0.745930169619625	0.694719570913191	0.728470804269576	0.724599629090397	NA	NA	0.645902233081452	0.687893582459588	NA	NA	p.Lys191Ser	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.249	-3.242	0.993	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191T	191	K	T	missense	possibly_low	0.610382460601033	0.357071908032685	6	0.145773996027013	0.324670678505601	0.896094242696464	0.909495656592753	1.06968591591175	0.494400384270054	0.612526043118013	NA	NA	0.0473897965884166	0.52879696712521	0.59329446648808	0.667001869927908	0.688606298875192	0.566453226869581	0.596003358594748	NA	NA	0.495480040434944	0.590585574381413	NA	NA	p.Lys191Thr	1	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.249	-3.053	0.804	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191V	191	K	V	missense	wt-like	0.851684521537305	0.087570062040513	6	0.0357503281238539	0.781615165979062	0.921753877095548	0.861547176830058	0.86828497491248	0.843659861610252	0.702347338601757	NA	NA	0.857819037516827	0.976448739752458	0.65948917523627	0.656788902722042	0.645061045031353	0.67095690241196	0.625752519493977	NA	NA	0.662189447750497	0.691263119362277	NA	NA	p.Lys191Val	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.249	-2.843	0.594	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191W	191	K	W	missense	possibly_wt-like	0.768523129227446	0.0883243443598595	6	0.0360582625912542	0.6978502332035	0.839196025251392	0.620765815119465	0.741589454993998	0.814067995183159	0.887648244493997	NA	NA	0.765379978427079	0.78168728714698	0.645317622585545	0.6055027688737	0.617667982474871	0.662102572011706	0.687124897107467	NA	NA	0.643174264221328	0.647460980949762	NA	NA	p.Lys191Trp	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.249	-5.884	3.635	0.00901758	NA	NA	NA	NA	NA	NA	NA
K191X	191	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys191Ter	1	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K191Y	191	K	Y	missense	wt-like	0.934063763344366	0.108485011724638	6	0.0442888205775357	0.84725927009464	1.02086825659409	1.07899824590722	0.881868098722296	0.82551690317515	0.826389031323899	NA	NA	0.950449165929864	1.04116113500777	0.674039771843432	0.703105712939109	0.647997876266381	0.665528257050294	0.666835608477832	NA	NA	0.681243935209033	0.705817032654967	NA	NA	p.Lys191Tyr	0	36.7	-4	11.2	0.729	119.1	25.8	-96.9	-25.8	43.0434782608696	-2.4	0	0	20.58	0	0	0	0	7	22.3758034738235	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.249	-4.716	2.467	0.00901758	NA	NA	NA	NA	NA	NA	NA
H192A	192	H	A	missense	possibly_wt-like	0.769639542116311	0.19930075809328	6	0.0813641937797334	0.610168652676895	0.929110431555726	0.780028594345178	0.622470750091782	0.610053843302006	0.593838644910245	NA	NA	0.938665644523625	1.07277977552503	0.620242010943679	0.639425544932448	0.591913116500659	0.60105847695491	0.589814019940959	NA	NA	0.678820005061259	0.712928111617589	NA	NA	p.His192Ala	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-2.791	-3.025	0.234	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192C	192	H	C	missense	possibly_low	0.573570557695358	0.314014167956832	6	0.128195747249809	0.322311510114533	0.824829605276183	1.00530122172211	0.544819108660019	0.832162190143031	0.106344597825664	NA	NA	0.446802686094844	0.50599354172648	0.581549174457993	0.687408337445715	0.575123917697714	0.667516626609987	0.428354103714741	NA	NA	0.577641298594299	0.585457050321686	NA	NA	p.His192Cys	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-2.791	-4.407	1.616	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192D	192	H	D	missense	wt-like	0.866084294947785	0.135604415788403	6	0.0553602709249662	0.757580157760471	0.974588432135098	0.733515904060254	1.03026276211922	0.906858480916107	0.679828089469401	NA	NA	0.970856040379532	0.875184492742191	0.674285594821983	0.629518399119117	0.680082549032203	0.689866877473946	0.618294056975035	NA	NA	0.685441732836337	0.668488640611762	NA	NA	p.His192Asp	1	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-2.791	-3.512	0.721	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192E	192	H	E	missense	wt-like	0.893688925326647	0.112005603348176	6	0.0457260960892662	0.804067423838068	0.983310426815227	1.02581215975933	0.978534591815537	0.937108441124325	0.869366083898425	NA	NA	0.837827702009429	0.713484573352834	0.674984042257521	0.691777142016213	0.668898309794912	0.698918119406861	0.68106977472013	NA	NA	0.658077128592237	0.632122089861432	NA	NA	p.His192Glu	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-2.791	-3.297	0.506	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192F	192	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His192Phe	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-2.791	-2.768	-0.023	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192G	192	H	G	missense	low	0.500189186088304	0.171344546524333	6	0.0699511181988649	0.363087513740224	0.637290858436384	0.465040920528732	0.821360000535863	0.502635080268743	0.50287913969312	NA	NA	0.352506268665331	0.356713706838036	0.564302525513703	0.572333557890091	0.634915313284981	0.568917171457114	0.559687879570291	NA	NA	0.558244047029628	0.551883794923831	NA	NA	p.His192Gly	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-2.791	-4.08	1.289	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192I	192	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His192Ile	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-2.791	-2.785	-0.006	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192K	192	H	K	missense	possibly_low	0.628455777602587	0.464609718926033	6	0.189676123484449	0.256697406845896	1.00021414835928	0.674399349866151	1.51005263054576	0.534901607032988	0.50069687890384	NA	NA	0.162351229459198	0.388332969807585	0.568783407117465	0.616926645797714	0.783818765500087	0.578571800358038	0.558965106346027	NA	NA	0.519128190538807	0.558995013876893	NA	NA	p.His192Lys	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-2.791	-2.619	-0.172	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192L	192	H	L	missense	possibly_wt-like	0.802853623485199	0.279583136342778	6	0.114139337454464	0.579144632855185	1.02656261411521	0.997256788742613	1.16631713527086	0.488074855229448	0.824066932529409	NA	NA	0.878635805725408	0.462770223413457	0.666269041484349	0.685694883116901	0.709499105807247	0.564560533679041	0.666066520364716	NA	NA	0.666471562603982	0.575736062179179	NA	NA	p.His192Leu	1	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-2.791	-2.288	-0.503	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192M	192	H	M	missense	wt-like	1.16296851653815	0.204414410862498	6	0.0834518337807924	0.999405927883973	1.32653110519233	0.800724640653576	1.04827354482967	1.30181945686253	1.33608659938756	NA	NA	1.27455427897024	1.21635257852531	0.746565924359492	0.643833777336997	0.68397669223313	0.808045127056571	0.835649416835962	NA	NA	0.747914001606199	0.745217847112785	NA	NA	p.His192Met	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-2.791	-2.302	-0.489	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192N	192	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His192Asn	1	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-2.791	-3.686	0.895	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192P	192	H	P	missense	low	0.320061681438902	0.28525424582288	6	0.116454558204749	0.0918149415220705	0.548308421355734	0.608705300082571	0.743920000925333	0.133844812984655	0.0419552684758444	NA	NA	0.219023257255195	0.172921448909814	0.52066727941652	0.602933894007025	0.618171873934718	0.458569590544074	0.407028108484935	NA	NA	0.530785914233991	0.510548644599048	NA	NA	p.His192Pro	1	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-2.791	-3.968	1.177	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192Q	192	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His192Gln	1	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-2.791	-3.186	0.395	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192R	192	H	R	missense	wt-like	0.966791081516942	0.15038992746375	6	0.0613964307900601	0.846456288389118	1.08712587464477	0.858387864126823	0.78207906993766	1.18282090163228	1.10039974578113	NA	NA	0.961963073932992	0.915095833690771	0.680538582331935	0.656115973002666	0.626422313770509	0.772438974002401	0.757589018218801	NA	NA	0.683612404511656	0.677464760152214	NA	NA	p.His192Arg	1	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-2.791	-2.687	-0.104	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192S	192	H	S	missense	possibly_wt-like	0.738004346303634	0.362075014511248	3	0.209044107094907	0.328285425217282	1.14772326738998	0.747359995887826	1.09531087200057	0.371342171022509	NA	NA	NA	NA	NA	0.632467173648148	0.632467173648148	0.694146715975968	0.529632363229795	NA	NA	NA	NA	NA	NA	NA	p.His192Ser	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-2.791	-3.04	0.249	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192T	192	H	T	missense	possibly_low	0.708043337300387	0.288575694418082	6	0.117810533915604	0.477138933826369	0.938947740774405	1.00989967048187	1.10405992927396	0.603721736002643	0.670653157913574	NA	NA	0.402625622539046	0.457299907591227	0.607209549782135	0.688387801374785	0.696038365131001	0.599163815450657	0.615255284113614	NA	NA	0.568553852447993	0.57450578006945	NA	NA	p.His192Thr	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-2.791	-3.295	0.504	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192V	192	H	V	missense	wt-like	0.901219705211899	0.0967636125821102	6	0.0395035794157541	0.823794112296603	0.978645298127194	0.960392743698176	1.01397367844458	0.943124537756097	0.828291647966846	NA	NA	0.748306846652307	0.913228776753387	0.67680275685762	0.677842886870561	0.676560657426451	0.700718225778279	0.667465762477902	NA	NA	0.639662234379053	0.677044856288788	NA	NA	p.His192Val	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-2.791	-3.073	0.282	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192W	192	H	W	missense	wt-like	1.20512887827733	0.0990511961965771	6	0.0404374815156533	1.12587287088114	1.28438488567351	1.15897201794099	1.07107127195745	1.14544407152624	1.22640825861001	NA	NA	1.33725748782659	1.29162016180267	0.76103381776111	0.720140028002959	0.688905829157299	0.76125526567199	0.799323525638564	NA	NA	0.76081236985023	0.762145637784837	NA	NA	p.His192Trp	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-2.791	-4.153	1.362	0.008338528	NA	NA	NA	NA	NA	NA	NA
H192X	192	H	X	nonsense	possibly_low	0.403696766400194	0.483270204748001	6	0.197294234920492	0.017007171598645	0.790386361201744	-0.373260199216083	0.0208019023474614	0.818231614407409	0.851635904554254	NA	NA	0.532707679603462	0.572063696704664	0.597814358729362	0.393776450616466	0.461825230242712	0.663348389350169	0.675197470660817	NA	NA	0.595312391676851	0.600316325781872	NA	NA	p.His192Ter	0	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H192Y	192	H	Y	missense	wt-like	1.44575956725145	0.290527079533953	6	0.118607183553195	1.21329375917945	1.67822537532344	1.03308062767257	1.20542055292618	1.56937786359159	1.4697586943032	NA	NA	1.85719054995624	1.53972911505889	0.842855473495991	0.693325316740462	0.717953724934219	0.888102616515084	0.879922132320257	NA	NA	0.867765239087893	0.817945707904089	NA	NA	p.His192Tyr	1	33.2	-2.3	11.4	0.994	62.5	-153.1	-140.5	128.9	10.1851851851852	-1.1	0	0	19.8	1	3	0	0	7	18.6583805009265	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-2.791	-2.767	-0.024	0.008338528	NA	NA	NA	NA	NA	NA	NA
P193A	193	P	A	missense	wt-like	1.28528661288977	0.393917809809367	4	0.196958904904684	0.899254252842138	1.6713189729374	NA	NA	NA	NA	1.77737916304017	1.30040697619611	1.24904798906951	0.814312323253277	0.736264579648384	NA	NA	NA	NA	0.765865362768124	0.729861930952721	0.742667228344046	0.654798399767109	NA	NA	p.Pro193Ala	1	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.398	-2.151	-0.247	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193C	193	P	C	missense	wt-like	1.24572856482335	0.25350402291407	3	0.146360615870091	0.958867028962874	1.53259010068383	NA	NA	NA	NA	1.53507774661752	1.06268630681055	1.13942164104199	NA	0.720116532264892	NA	NA	NA	NA	0.730437326708445	0.684188249219364	0.720116532264892	NA	NA	NA	p.Pro193Cys	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.398	-4.194	1.796	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193D	193	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro193Asp	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.398	-2.408	0.01	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193E	193	P	E	missense	possibly_low	0.567447318761992	0.230297713986212	4	0.115148856993106	0.341759706194551	0.793134931329433	NA	NA	NA	NA	0.332629573793796	0.794806980512674	0.409541725227392	0.732810995514105	0.601348331322468	NA	NA	NA	NA	0.554621692381385	0.632720132778756	0.569976529866181	0.63646863075647	NA	NA	p.Pro193Glu	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.398	-2.445	0.047	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193F	193	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro193Phe	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.398	-4.822	2.424	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193G	193	P	G	missense	wt-like	0.918741441697601	0.0380530329551421	4	0.0190265164775711	0.881450154650304	0.956032728744898	NA	NA	NA	NA	0.935506219403558	0.902679942204044	0.962006445708574	0.874773159474228	0.660921040947362	NA	NA	NA	NA	0.642771138041018	0.653445950742591	0.68362132630598	0.668396131152134	NA	NA	p.Pro193Gly	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.398	-2.919	0.521	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193H	193	P	H	missense	wt-like	1.11617792556778	0.144657020200208	3	0.0835177695527595	0.952486105175252	1.2798697459603	NA	NA	NA	NA	1.07204723899418	0.998726189720473	NA	1.27776034798867	0.67189948173797	NA	NA	NA	NA	0.662735446286101	0.67189948173797	NA	0.759028545182935	NA	NA	p.Pro193His	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.398	-5.133	2.735	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193I	193	P	I	missense	low	0.500834573366708	0.111371308526163	4	0.0556856542630813	0.39169269655552	0.609976450177897	NA	NA	NA	NA	0.603829130436945	0.342513074594344	0.5303138208852	0.526682267550344	0.592192518759714	NA	NA	NA	NA	0.594275062196453	0.545820125462414	0.594819962791066	0.590109975322975	NA	NA	p.Pro193Ile	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.398	-3.505	1.107	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193K	193	P	K	missense	low	0.448752649999528	0.15790210011155	3	0.0911648200050106	0.270072886132631	0.627432413866426	NA	NA	NA	NA	0.312126812477133	0.412504062408647	NA	0.621627075112805	0.559267614525508	NA	NA	NA	NA	0.551623886681468	0.559267614525508	NA	0.611463202805956	NA	NA	p.Pro193Lys	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.398	-2.467	0.069	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193L	193	P	L	missense	possibly_wt-like	0.841284959881196	0.206138552559391	4	0.103069276279696	0.639272890460384	1.04329702930201	NA	NA	NA	NA	0.807994246377148	1.10812892157613	0.842601047637343	0.606415623934159	0.641593019703406	NA	NA	NA	NA	0.624127009396964	0.692919217078825	0.659059030009849	0.608042124963967	NA	NA	p.Pro193Leu	1	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.398	-3.403	1.005	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193M	193	P	M	missense	wt-like	1.49344233979582	0.264363791752958	2	0.186933429848705	1.12705954978582	1.85982512980583	NA	NA	NA	NA	1.68037576964453	1.30650890994712	NA	NA	0.741358171919193	NA	NA	NA	NA	0.751682037842208	0.731034305996178	NA	NA	NA	NA	p.Pro193Met	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.398	-4.117	1.719	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193N	193	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro193Asn	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.398	-2.844	0.446	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193Q	193	P	Q	missense	wt-like	1.44182152006342	0.29852643325497	4	0.149263216627485	1.14927099125695	1.73437204886989	NA	NA	NA	NA	1.77395805380697	1.59625399923979	1.28460478985311	1.1124692373538	0.75767329445115	NA	NA	NA	NA	0.765365146207002	0.786703529149394	0.749981442695297	0.721854330216212	NA	NA	p.Pro193Gln	1	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.398	-2.756	0.358	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193R	193	P	R	missense	wt-like	0.892206131864423	0.0950347800782829	4	0.0475173900391414	0.799073758748363	0.985338504980482	NA	NA	NA	NA	0.799347865872901	0.844870667730326	1.01889090889866	0.905715084955801	0.658846985576364	NA	NA	NA	NA	0.622862781210383	0.64233895524921	0.695322749039715	0.675355015903517	NA	NA	p.Pro193Arg	1	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.398	-3.31	0.912	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193S	193	P	S	missense	wt-like	1.01410584650732	0.158661869769381	4	0.0793309348846904	0.858620071273439	1.16959162174121	NA	NA	NA	NA	1.1328756611357	1.02511579874436	1.1118072987866	0.786624627362645	0.67429961017843	NA	NA	NA	NA	0.671629457575428	0.676969762781432	0.714436121936247	0.648571396058209	NA	NA	p.Pro193Ser	1	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.398	-2.395	-0.003	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193T	193	P	T	missense	wt-like	1.1501726544275	0.314946582086737	4	0.157473291043368	0.841530675455508	1.4588146333995	NA	NA	NA	NA	1.13352741122751	1.52709566293033	1.18254964901652	0.757517894535656	0.700356467696794	NA	NA	NA	NA	0.671724753038804	0.773416018854345	0.728988182354784	0.642025248845976	NA	NA	p.Pro193Thr	1	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.398	-3	0.602	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193V	193	P	V	missense	low	0.624573016006816	0.0413170050234665	4	0.0206585025117332	0.584083095109288	0.665062936904343	NA	NA	NA	NA	0.663383227149172	0.588732115900343	0.657191686565352	0.588985034412397	0.603552353984057	NA	NA	NA	NA	0.602982748337842	0.593126614033094	0.620919383592775	0.604121959630272	NA	NA	p.Pro193Val	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.398	-3.44	1.042	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193W	193	P	W	missense	low	0.519027003619489	0.134715195170372	4	0.0673575975851858	0.387008538267383	0.651045468971596	NA	NA	NA	NA	0.390527395612033	0.610529168396872	0.65768260312667	0.417368847342382	0.58141987245427	NA	NA	NA	NA	0.563087206737171	0.597314519279302	0.621020367620554	0.565525225629237	NA	NA	p.Pro193Trp	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.398	-5.97	3.572	0.00794114	NA	NA	NA	NA	NA	NA	NA
P193X	193	P	X	nonsense	low	0.498424921081052	0.221360530188503	4	0.110680265094251	0.281495587696974	0.715354254465131	NA	NA	NA	NA	0.296501475975965	0.337311929907567	0.59516916817053	0.764717110270148	0.578750134581196	NA	NA	NA	NA	0.549339232331605	0.544820820573668	0.608161036830788	0.643644363100081	NA	NA	p.Pro193Ter	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P193Y	193	P	Y	missense	wt-like	1.39514304322315	0.246600030432053	4	0.123300015216027	1.1534794541065	1.6368066323398	NA	NA	NA	NA	1.66436608523619	1.25527235826799	1.53298088152821	1.12795284786022	0.737338901630072	NA	NA	NA	NA	0.749341186167064	0.721190139056233	0.801073665116929	0.72533661709308	NA	NA	p.Pro193Tyr	0	31.4	-0.9	8.3	0.526	56.8	-126.6	-80.8	-2	44.8051948051948	-0.2	0	0	19.43	0	0	0	0	4	17.1804873253216	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.398	-4.174	1.776	0.00794114	NA	NA	NA	NA	NA	NA	NA
G194A	194	G	A	missense	possibly_wt-like	0.787953443766237	0.176630571032059	4	0.0883152855160295	0.614858664870447	0.961048222662026	NA	NA	NA	NA	1.0093183892486	0.580781028498641	0.752825828565031	0.808888528752669	0.647077688189207	NA	NA	NA	NA	0.653563564488712	0.59159895791317	0.640591811889703	0.653578580371338	NA	NA	p.Gly194Ala	1	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.881	-2.562	1.681	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194C	194	G	C	missense	possibly_wt-like	0.788007125329274	0.270829168041286	4	0.135414584020643	0.52259941766734	1.05341483299121	NA	NA	NA	NA	1.16937914583917	0.528926985389489	0.726348437492671	0.72737393259577	0.635195552731362	NA	NA	NA	NA	0.676966804717149	0.581636151281013	0.635145278188773	0.635245827273951	NA	NA	p.Gly194Cys	1	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.881	-5.35	4.469	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194D	194	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly194Asp	1	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.881	-2.905	2.024	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194E	194	G	E	missense	possibly_wt-like	0.827159708447439	0.192138068079848	4	0.0960690340399239	0.638867861699636	1.01545155519524	NA	NA	NA	NA	0.971919361371846	0.631569491628411	1.01108106042574	0.694068920363762	0.637925378282777	NA	NA	NA	NA	0.648095275744153	0.6013570328282	0.6937162235784	0.627755480821401	NA	NA	p.Gly194Glu	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.881	-3.286	2.405	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194F	194	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly194Phe	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.881	-4.591	3.71	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194G	194	G	G	synonymous	wt-like	1.11157670485115	0.0807413711885476	4	0.0403706855942738	1.03245161505518	1.19070179464712	NA	NA	NA	NA	1.20803911424227	1.14706558254424	1.05759020467244	1.03361191794565	0.701841787692033	NA	NA	NA	NA	0.682619461539683	0.700400184827289	0.703283390556778	0.70411920258522	NA	NA	p.Gly194=	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194H	194	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly194His	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.881	-3.786	2.905	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194I	194	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly194Ile	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.881	-4.428	3.547	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194K	194	G	K	missense	wt-like	1.08247533405731	0.297341063377748	4	0.148670531688874	0.791086446384694	1.37386422172992	NA	NA	NA	NA	0.887545087645597	1.1169896789678	1.4891641052353	0.836202464380535	0.677171587253003	NA	NA	NA	NA	0.635758514134519	0.69462164966102	0.792060331888847	0.659721524844985	NA	NA	p.Gly194Lys	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.881	-3.905	3.024	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194L	194	G	L	missense	low	0.666912948977775	0.0515106525366139	4	0.0257553262683069	0.616433437081815	0.717392460873735	NA	NA	NA	NA	0.697385337617623	0.606979137062063	0.642878818533237	0.720408502698175	0.612964755865754	NA	NA	NA	NA	0.607954357722412	0.596632445643262	0.617975154009096	0.633679291799936	NA	NA	p.Gly194Leu	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.881	-3.991	3.11	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194M	194	G	M	missense	possibly_wt-like	0.79163205130145	0.207573843676618	3	0.119842814523421	0.556744451029631	1.02651965157327	NA	NA	NA	NA	0.727329753975262	0.623818674366586	NA	1.0237477255625	0.612332672460176	NA	NA	NA	NA	0.612332672460176	0.599867854955258	NA	0.701900731145856	NA	NA	p.Gly194Met	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.881	-5.148	4.267	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194N	194	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly194Asn	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.881	-3.857	2.976	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194P	194	G	P	missense	possibly_wt-like	0.787642983310727	0.128068965665647	4	0.0640344828328237	0.662137703189745	0.91314826343171	NA	NA	NA	NA	0.866207690925428	0.607081976774042	0.889771686450466	0.787510579092974	0.640704660178013	NA	NA	NA	NA	0.632638672444848	0.596652204414288	0.668762269777238	0.648770647911178	NA	NA	p.Gly194Pro	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.881	-3.21	2.329	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194Q	194	G	Q	missense	low	0.573460397503054	0.10040396300991	4	0.050201981504955	0.475066321800796	0.671854473205311	NA	NA	NA	NA	0.566225989872238	0.55310976892128	0.466017781437321	0.708488049781376	0.587529680155696	NA	NA	NA	NA	0.588776929170438	0.586282431140953	0.581593941211669	0.630998364328835	NA	NA	p.Gly194Gln	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.881	-3.554	2.673	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194R	194	G	R	missense	possibly_wt-like	0.854813042827079	0.149705232814522	4	0.0748526164072609	0.708104610520256	1.0015214751339	NA	NA	NA	NA	0.899670613933081	0.642566105505574	0.994025318404459	0.882990133465202	0.653887792711173	NA	NA	NA	NA	0.637531444680688	0.603469831196421	0.690207770896662	0.670244140741658	NA	NA	p.Gly194Arg	1	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.881	-3.492	2.611	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194S	194	G	S	missense	possibly_wt-like	0.790934991941338	0.276478909084931	4	0.138239454542466	0.519990639795643	1.06187934408703	NA	NA	NA	NA	0.970932937749658	0.519756020585505	1.08068475274352	0.592366256686671	0.626416723797953	NA	NA	NA	NA	0.647951046081062	0.57987411801429	0.708034056286383	0.604882401514844	NA	NA	p.Gly194Ser	1	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.881	-2.813	1.932	0.004450878	NA	NA	NA	NA	4.32e-06	NA	NA
G194T	194	G	T	missense	wt-like	0.961565058122451	0.127189721520951	4	0.0635948607604755	0.836921421430079	1.08620869481482	NA	NA	NA	NA	0.835770533694717	0.933732385072139	0.938048955839973	1.13870835788297	0.669052629577479	NA	NA	NA	NA	0.628188311733614	0.659412110085262	0.678693149069695	0.727755547186337	NA	NA	p.Gly194Thr	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.881	-2.8	1.919	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194V	194	G	V	missense	low	0.503523416069633	0.0960799850308378	4	0.0480399925154189	0.409366760921839	0.597680071217428	NA	NA	NA	NA	0.517140035370715	0.369384356653316	0.597344744162147	0.530224528092356	0.586253237281309	NA	NA	NA	NA	0.581599839610754	0.550982951175891	0.608608563852045	0.590906634951864	NA	NA	p.Gly194Val	1	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.881	-3.989	3.108	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194W	194	G	W	missense	low	0.513494714409125	0.0686602989961496	4	0.0343301494980748	0.446208857809022	0.580780571009227	NA	NA	NA	NA	0.609884434399123	0.465737221920521	0.462830858911753	0.5155263424051	0.58426968317676	NA	NA	NA	NA	0.595160436827323	0.569495393167941	0.580938375076383	0.587600991277136	NA	NA	p.Gly194Trp	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.881	-3.896	3.015	0.004450878	NA	NA	NA	NA	NA	NA	NA
G194X	194	G	X	nonsense	low	0.153767439683579	0.140269661171475	4	0.0701348305857375	0.0163056976737156	0.291229181693443	NA	NA	NA	NA	0.0744272841355473	0.00762996981392834	0.321075627371403	0.211936877413438	0.518095993274923	NA	NA	NA	NA	0.516868714442751	0.481478457633725	0.551778604623261	0.519323272107095	NA	NA	p.Gly194Ter	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G194Y	194	G	Y	missense	wt-like	1.0852249486888	0.262269152989032	4	0.131134576494516	0.828205901631636	1.34224399574596	NA	NA	NA	NA	1.22071236291259	0.837490729566213	1.38663040356604	0.896066298710353	0.67882873339432	NA	NA	NA	NA	0.684472477165899	0.640921035016229	0.770968629156638	0.673184989622742	NA	NA	p.Gly194Tyr	0	29.5	1.6	10.4	0.204	56.8	-177.5	82.3	171.3	9.27835051546392	-0.7	0	0	17.5	0	0	0	0	6	13.5871837743278	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.881	-4.604	3.723	0.004450878	NA	NA	NA	NA	NA	NA	NA
P195A	195	P	A	missense	possibly_low	0.653540101920241	0.342694700358585	4	0.171347350179292	0.317705466722456	0.989374737118027	NA	NA	NA	NA	0.458898135226694	0.280010358079448	0.855469210952787	1.01978270342204	0.617395046218954	NA	NA	NA	NA	0.573084015935636	0.533811370864211	0.661706076502273	0.701008991808929	NA	NA	p.Pro195Ala	1	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-0.856	-2.97	2.114	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195C	195	P	C	missense	low	-0.0880868196061221	0.0557593378493443	4	0.0278796689246721	-0.14272996659938	-0.0334436726128641	NA	NA	NA	NA	-0.152851231167957	-0.112178410132601	-0.0610482259639821	-0.026269411159949	0.469462057420162	NA	NA	NA	NA	0.483637247806512	0.458459467199235	0.473173788936082	0.465750325904242	NA	NA	p.Pro195Cys	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-0.856	-5.314	4.458	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195D	195	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro195Asp	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-0.856	-3.231	2.375	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195E	195	P	E	missense	possibly_wt-like	0.812744586302672	0.199261634890765	4	0.0996308174453826	0.617471772359437	1.00801740024591	NA	NA	NA	NA	0.803347999303457	0.556374202372796	0.850797996379648	1.04045814715479	0.642096421799389	NA	NA	NA	NA	0.623447659637895	0.586909632363673	0.660745183960883	0.705658929648305	NA	NA	p.Pro195Glu	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-0.856	-3.748	2.892	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195F	195	P	F	missense	low	0.521188944254721	0.171376471802808	4	0.0856882359014038	0.353243087989198	0.689134800520245	NA	NA	NA	NA	0.424868452673898	0.329849711728874	0.644436194420574	0.685601418195538	0.593201944619055	NA	NA	NA	NA	0.568108375106212	0.543387091739741	0.618295514131897	0.625851127074707	NA	NA	p.Pro195Phe	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-0.856	-3.614	2.758	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195G	195	P	G	missense	low	0.597265774440544	0.106401507216489	4	0.0532007536082443	0.492994213417996	0.701537335463092	NA	NA	NA	NA	0.629383818906632	0.440066221405445	0.645701882928164	0.673911174521935	0.608283703369522	NA	NA	NA	NA	0.598011534058503	0.564563179615232	0.618555872680541	0.62322197400249	NA	NA	p.Pro195Gly	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-0.856	-3.679	2.823	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195H	195	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro195His	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-0.856	-3.724	2.868	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195I	195	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro195Ile	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-0.856	-4.15	3.294	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195K	195	P	K	missense	low	-0.19300854377567	0.285052924667133	4	0.142526462333567	-0.472355276793365	0.0863381892420251	NA	NA	NA	NA	-0.450183734358483	-0.429018307197539	0.0660363039608956	0.0411315624924475	0.460535880365631	NA	NA	NA	NA	0.440162856280983	0.397584471952176	0.499315721621633	0.480908904450279	NA	NA	p.Pro195Lys	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-0.856	-3.028	2.172	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195L	195	P	L	missense	low	0.304537401997011	0.15284283231586	4	0.0764214161579299	0.154754178679921	0.454320625314101	NA	NA	NA	NA	0.42712536601725	0.215216126452809	0.135386257646266	0.440421857871717	0.544900356300092	NA	NA	NA	NA	0.568438369080215	0.521362343519969	0.513581359005354	0.57070988175355	NA	NA	p.Pro195Leu	1	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-0.856	-3.212	2.356	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195M	195	P	M	missense	low	0.339835026932107	0.294854542659965	4	0.147427271329982	0.0508828847863266	0.628787169077887	NA	NA	NA	NA	-0.0253000010399435	0.344490067236866	0.696850917277349	0.343299124254156	0.547533401973967	NA	NA	NA	NA	0.502287116417058	0.546199968464611	0.629077488597739	0.548866835483323	NA	NA	p.Pro195Met	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-0.856	-4.937	4.081	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195N	195	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro195Asn	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-0.856	-4.109	3.253	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195P	195	P	P	synonymous	wt-like	1.26786250093402	0.327130558851002	4	0.163565279425501	0.94728044413881	1.58844455772923	NA	NA	NA	NA	1.4801680216429	1.61141053356482	1.0315153850034	0.948356063524966	0.710164191980347	NA	NA	NA	NA	0.722408716124368	0.78961558019961	0.697919667836327	0.684945034977338	NA	NA	p.Pro195=	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195Q	195	P	Q	missense	low	0.215550871523358	0.439075525357886	4	0.219537762678943	-0.214735236573871	0.645836979620587	NA	NA	NA	NA	0.590093881586151	0.546408240900051	0.062623099807781	-0.33692173620055	0.541804231612372	NA	NA	NA	NA	0.592266766501121	0.58499485501743	0.498613608207313	0.395884159075215	NA	NA	p.Pro195Gln	1	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-0.856	-4.223	3.367	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195R	195	P	R	missense	low	0.526922679603103	0.138248821509871	4	0.0691244107549355	0.391441324070876	0.66240403513533	NA	NA	NA	NA	0.488919214029056	0.353260301288464	0.591926015616928	0.673585187477964	0.59248372187271	NA	NA	NA	NA	0.577473539852019	0.547885008641534	0.607493903893401	0.623148659034719	NA	NA	p.Pro195Arg	1	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-0.856	-4.187	3.331	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195S	195	P	S	missense	possibly_low	0.381757813397127	0.365276521690334	4	0.182638260845167	0.0237933999415678	0.739722226852687	NA	NA	NA	NA	0.463209121131449	0.468688391722839	0.728793806642158	-0.133660065907937	0.571888376039827	NA	NA	NA	NA	0.573714345573578	0.570062406506076	0.635648303031648	0.441598009002958	NA	NA	p.Pro195Ser	1	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-0.856	-2.822	1.966	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195T	195	P	T	missense	possibly_low	0.656168151954202	0.136914072020035	4	0.0684570360100175	0.521994826886206	0.790341477022197	NA	NA	NA	NA	0.752019682377046	0.45886072358644	0.668347413764081	0.745444788089239	0.619578438474595	NA	NA	NA	NA	0.615942703662815	0.568174199696786	0.623214173286374	0.639309989370549	NA	NA	p.Pro195Thr	1	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-0.856	-2.827	1.971	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195V	195	P	V	missense	possibly_wt-like	0.755759233577705	0.0753600567687486	4	0.0376800283843743	0.681907735007885	0.829610732147526	NA	NA	NA	NA	0.803162664304976	0.652077335450519	0.748850212840717	0.81894672171461	0.631597284246251	NA	NA	NA	NA	0.623420560931225	0.605297240190855	0.639774007561276	0.65584068282747	NA	NA	p.Pro195Val	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-0.856	-3.228	2.372	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195W	195	P	W	missense	possibly_low	0.614051827337383	0.186260179918634	4	0.0931300899593172	0.431520205140146	0.79658344953462	NA	NA	NA	NA	0.836726871750804	0.424512416366968	0.692405596813649	0.502562424418112	0.60642422529559	NA	NA	NA	NA	0.628328142443795	0.561574800258459	0.628163063620943	0.584685386970237	NA	NA	p.Pro195Trp	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-0.856	-5.745	4.889	0.003970417	NA	NA	NA	NA	NA	NA	NA
P195X	195	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro195Ter	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P195Y	195	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro195Tyr	0	27.3	3.2	11.6	0.69	105.9	45.4	-79.1	163.1	16.8831168831169	-0.4	0	0	14.72	0	0	0	0	5	10.6856743186674	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-0.856	-4.536	3.68	0.003970417	NA	NA	NA	NA	NA	NA	NA
P196A	196	P	A	missense	possibly_wt-like	0.853528339279845	0.219592967637416	4	0.109796483818708	0.638331185366042	1.06872549319365	NA	NA	NA	NA	1.1405335847967	0.633603090398225	0.896389339919359	0.743587342005091	0.654507900839371	NA	NA	NA	NA	0.672749158812053	0.60174775166315	0.670123554676528	0.638892247002214	NA	NA	p.Pro196Ala	1	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-0.711	-2.717	2.006	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196C	196	P	C	missense	low	0.246138667123586	0.044654002191331	2	0.0315751477566091	0.184252514714102	0.308024819533071	NA	NA	NA	NA	0.277713814880195	0.214563519366977	NA	NA	0.533914578271432	NA	NA	NA	NA	0.546592199546551	0.521236956996313	NA	NA	NA	NA	p.Pro196Cys	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-0.711	-3.682	2.971	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196D	196	P	D	missense	possibly_low	0.603010871742607	0.192699385506452	4	0.0963496927532262	0.414168944024783	0.79185279946043	NA	NA	NA	NA	0.608180935615294	0.328857036817499	0.733261872083386	0.741743642454247	0.615739383489591	NA	NA	NA	NA	0.594911360213442	0.543196367398925	0.636567406765739	0.638477596249528	NA	NA	p.Pro196Asp	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-0.711	-3.743	3.032	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196E	196	P	E	missense	low	0.134777334341527	0.334996394178959	4	0.167498197089479	-0.193513099429244	0.463067768112299	NA	NA	NA	NA	-0.307753427607898	0.0717448107538565	0.454879331371668	0.320238622848484	0.518738723562395	NA	NA	NA	NA	0.460988265055107	0.493796952474935	0.579302705512014	0.543680494649855	NA	NA	p.Pro196Glu	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-0.711	-3.106	2.395	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196F	196	P	F	missense	low	0.22077746285167	0.240590302938325	4	0.120295151469163	-0.0149967015426795	0.456551627246019	NA	NA	NA	NA	0.0233632448426755	0.207259605798549	0.563150449972064	0.0893365507933904	0.514618021625121	NA	NA	NA	NA	0.509402399750372	0.51983364349987	0.601574624021009	0.491750277532502	NA	NA	p.Pro196Phe	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-0.711	-4.729	4.018	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196G	196	P	G	missense	low	0.504749622784227	0.083589640721416	4	0.041794820360708	0.422833280136918	0.586665965431536	NA	NA	NA	NA	0.532829420097811	0.380826114149807	0.542108226140233	0.563234730749055	0.590569995278206	NA	NA	NA	NA	0.583893858754646	0.553181275754547	0.597246131801766	0.598330678295404	NA	NA	p.Pro196Gly	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-0.711	-3.612	2.901	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196H	196	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro196His	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-0.711	-4.941	4.23	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196I	196	P	I	missense	possibly_wt-like	0.780670484123402	0.274608555192514	2	0.194177571548467	0.400089437282958	1.16125153096385	NA	NA	NA	NA	0.586492912574935	0.974848055671869	NA	NA	0.629525993249633	NA	NA	NA	NA	0.591740251791208	0.667311734708058	NA	NA	NA	NA	p.Pro196Ile	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-0.711	-4.255	3.544	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196K	196	P	K	missense	low	0.325339686344889	0.306351883656481	3	0.176872342495818	-0.021323734808148	0.672003107497926	NA	NA	NA	NA	0.00303664473411209	0.360229420982786	0.61275299331777	NA	0.549223997614192	NA	NA	NA	NA	0.506430351413846	0.549223997614192	0.61177811889125	NA	NA	NA	p.Pro196Lys	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-0.711	-3.723	3.012	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196L	196	P	L	missense	low	0.529064608422786	0.143774636504147	4	0.0718873182520733	0.388168053703553	0.669961163142018	NA	NA	NA	NA	0.476103418049422	0.386472138126825	0.527455018824332	0.726227858690565	0.58491578720496	NA	NA	NA	NA	0.575599681709531	0.554266056067727	0.594231892700389	0.634988073559573	NA	NA	p.Pro196Leu	1	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-0.711	-3.819	3.108	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196M	196	P	M	missense	low	-0.314316082773517	0.123804674953502	2	0.0875431252022176	-0.485897455263944	-0.142734710283089	NA	NA	NA	NA	-0.226772957571299	-0.401859207975734	NA	NA	0.437815699524628	NA	NA	NA	NA	0.472828802576282	0.402802596472974	NA	NA	NA	NA	p.Pro196Met	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-0.711	-4.957	4.246	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196N	196	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro196Asn	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-0.711	-4.123	3.412	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196P	196	P	P	synonymous	wt-like	0.978047838794649	0.166437457248035	4	0.0832187286240174	0.814942127852363	1.14115354973694	NA	NA	NA	NA	1.20879825097219	0.979887336939477	0.824295495442621	0.899210271824306	0.671086007159952	NA	NA	NA	NA	0.682730458511302	0.668279940499235	0.655293485033374	0.673892073820669	NA	NA	p.Pro196=	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196Q	196	P	Q	missense	possibly_low	0.394287416945396	0.585034230201715	4	0.292517115100858	-0.179035593513842	0.967610427404634	NA	NA	NA	NA	-0.051910932780343	-0.0994518622462589	1.1308855014412	0.597626961366982	0.552230873999996	NA	NA	NA	NA	0.498396206230895	0.460904640768817	0.718360605033071	0.606065541769097	NA	NA	p.Pro196Gln	1	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-0.711	-3.353	2.642	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196R	196	P	R	missense	possibly_low	0.678753029394259	0.160207798338597	4	0.0801038991692983	0.521752272001206	0.835753786787311	NA	NA	NA	NA	0.860667968359355	0.476994085848091	0.727424272755129	0.649925790614459	0.62482815456819	NA	NA	NA	NA	0.631828683408345	0.571658193826682	0.635366582961499	0.617827625728036	NA	NA	p.Pro196Arg	1	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-0.711	-4.168	3.457	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196S	196	P	S	missense	possibly_wt-like	0.917450611349679	0.267018942603557	4	0.133509471301778	0.655776856003209	1.17912436669615	NA	NA	NA	NA	1.2353466912276	0.627423003633051	0.784488877568955	1.02254387296911	0.66685864663162	NA	NA	NA	NA	0.68661223152189	0.600560360946446	0.64710506174135	0.701629982919149	NA	NA	p.Pro196Ser	1	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-0.711	-2.883	2.172	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196T	196	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro196Thr	1	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-0.711	-3.685	2.974	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196V	196	P	V	missense	possibly_low	0.587671866258818	0.170077238414824	4	0.085038619207412	0.420999235317275	0.754344497200362	NA	NA	NA	NA	0.68973492122568	0.333247248082621	0.66045967089849	0.667245624828482	0.614213689356161	NA	NA	NA	NA	0.606835754159103	0.544039866252364	0.621591624553219	0.6217228820294	NA	NA	p.Pro196Val	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-0.711	-3.797	3.086	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196W	196	P	W	missense	possibly_low	0.57344308636591	0.201483904982099	4	0.10074195249105	0.375992487751208	0.770893684980613	NA	NA	NA	NA	0.506691547120427	0.319070246738726	0.710923367132355	0.757087184472133	0.60602218983498	NA	NA	NA	NA	0.580072116727555	0.541316014561267	0.631972262942404	0.641928381516401	NA	NA	p.Pro196Trp	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-0.711	-5.78	5.069	0.003078313	NA	NA	NA	NA	NA	NA	NA
P196X	196	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro196Ter	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P196Y	196	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro196Tyr	0	28.7	5.1	13.4	0.663	102.9	-146.5	-69.7	151.5	14.9350649350649	-0.3	0	0	14.54	0	0	0	0	6	10.3230949908486	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-0.711	-4.631	3.92	0.003078313	NA	NA	NA	NA	NA	NA	NA
F197A	197	F	A	missense	possibly_wt-like	0.893578354331433	0.268451198930042	4	0.134225599465021	0.630501013576694	1.15665569508617	NA	NA	NA	NA	1.2826386181531	0.732984145594417	0.859785928145332	0.69890472543288	0.645718553829499	NA	NA	NA	NA	0.693527007824832	0.620842005002956	0.662594047133606	0.628843060525392	NA	NA	p.Phe197Ala	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.175	-3.648	2.473	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197C	197	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe197Cys	1	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.175	-5.33	4.155	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197D	197	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe197Asp	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.175	-4.121	2.946	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197E	197	F	E	missense	possibly_low	0.6027404739611	0.314653188367396	4	0.157326594183698	0.294386015550703	0.911094932371496	NA	NA	NA	NA	0.671873027726364	0.205967557174119	0.565143519131667	0.967977791812249	0.603104345346775	NA	NA	NA	NA	0.604224082232744	0.51958539997183	0.601984608460805	0.689357990656373	NA	NA	p.Phe197Glu	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.175	-3.404	2.229	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197G	197	F	G	missense	possibly_low	0.569479907381268	0.155175981175814	4	0.0775879905879068	0.417410240196138	0.721549574566398	NA	NA	NA	NA	0.745829410964318	0.372133742346261	0.548564314143875	0.611392162070618	0.603867768803855	NA	NA	NA	NA	0.615037594802672	0.551511195385477	0.598574181865003	0.609161355742707	NA	NA	p.Phe197Gly	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.175	-3.903	2.728	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197H	197	F	H	missense	possibly_wt-like	0.892846011036912	0.19710367365144	4	0.0985518368257198	0.699687960248233	1.08600406182559	NA	NA	NA	NA	0.786180683807697	0.720290937625285	0.897521388126531	1.16739103458814	0.645646983991836	NA	NA	NA	NA	0.620937545246443	0.618403237089101	0.670356422737229	0.734206323550313	NA	NA	p.Phe197His	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.175	-2.383	1.208	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197I	197	F	I	missense	wt-like	1.43089107713498	0.252804981068371	4	0.126402490534185	1.18314674813181	1.67863540613815	NA	NA	NA	NA	1.7957909902873	1.26192871020497	1.40652626550677	1.25931834254087	0.761719177010984	NA	NA	NA	NA	0.768557443108661	0.722469035420862	0.775061308917763	0.754880910913307	NA	NA	p.Phe197Ile	1	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.175	-3.911	2.736	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197K	197	F	K	missense	possibly_wt-like	0.941766151622159	0.442013432421202	4	0.221006716210601	0.508600947507917	1.3749313557364	NA	NA	NA	NA	1.36512302478491	0.327008149547254	0.964487321456795	1.11044611069968	0.694859549032425	NA	NA	NA	NA	0.70558744302846	0.542841137502592	0.684131655036389	0.721399326042932	NA	NA	p.Phe197Lys	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.175	-3.426	2.251	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197L	197	F	L	missense	possibly_low	0.542589929918356	0.223348977382497	4	0.111674488691248	0.323711954091584	0.761467905745128	NA	NA	NA	NA	0.720124642745922	0.297867430170316	0.743500172842849	0.408867473914337	0.587446216628467	NA	NA	NA	NA	0.611279179070762	0.537242280887627	0.638673477185376	0.563613254186171	NA	NA	p.Phe197Leu	1	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.175	-2.966	1.791	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197M	197	F	M	missense	possibly_low	0.49771458615425	0.345376571061371	4	0.172688285530686	0.159251765962137	0.836177406346363	NA	NA	NA	NA	-0.00170780379334311	0.565908632793043	0.786823090583242	0.639834425034059	0.6021497808032	NA	NA	NA	NA	0.505736643155778	0.588741498905395	0.647585221203161	0.615558062701006	NA	NA	p.Phe197Met	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.175	-4.776	3.601	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197N	197	F	N	missense	possibly_low	0.469512455750835	0.302094280588769	4	0.151047140294384	0.173465500806073	0.765559410695597	NA	NA	NA	NA	0.662108481226602	0.115057074162164	0.329137150869191	0.771747116745383	0.578116631310943	NA	NA	NA	NA	0.602796361707592	0.50211861225814	0.553436900914294	0.645225421941806	NA	NA	p.Phe197Asn	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.175	-3.519	2.344	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197P	197	F	P	missense	possibly_wt-like	0.845252120641886	0.34462705161838	4	0.17231352580919	0.50752381600676	1.18298042527701	NA	NA	NA	NA	0.998085987813358	0.330754696155139	1.06374926149399	0.988418537105056	0.672938183210554	NA	NA	NA	NA	0.651921221951223	0.543560967956587	0.704550339798597	0.693955144469885	NA	NA	p.Phe197Pro	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.175	-3.634	2.459	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197Q	197	F	Q	missense	possibly_wt-like	1.01563486628104	0.367586965518818	4	0.183793482759409	0.655406259479418	1.37586347308267	NA	NA	NA	NA	1.4506096339366	0.670901576126467	0.754592058615154	1.18643619644595	0.67952098941752	NA	NA	NA	NA	0.718086844461438	0.608913973980675	0.640955134373602	0.738489608587596	NA	NA	p.Phe197Gln	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.175	-3.4	2.225	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197R	197	F	R	missense	low	0.572837725909205	0.116590141584253	4	0.0582950707921265	0.458581486680424	0.687093965137986	NA	NA	NA	NA	0.651135782456239	0.408712054553797	0.570869621839194	0.660633444787589	0.602177244184691	NA	NA	NA	NA	0.601191991525	0.558539049523817	0.603162496844381	0.620235792970015	NA	NA	p.Phe197Arg	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.175	-3.341	2.166	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197S	197	F	S	missense	low	0.333476733920983	0.120116346761779	4	0.0600581733808896	0.215764877117177	0.451188590724789	NA	NA	NA	NA	0.382622884791303	0.166225966111699	0.446940881767916	0.338117203013014	0.554816432283307	NA	NA	NA	NA	0.561931450825689	0.511949779617682	0.577669726145512	0.547701413740926	NA	NA	p.Phe197Ser	1	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.175	-3.374	2.199	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197T	197	F	T	missense	possibly_low	0.626572775355858	0.291787787558764	4	0.145893893779382	0.340625997983957	0.912519552727759	NA	NA	NA	NA	1.00109440169469	0.381114284537153	0.714644243475977	0.409438171715616	0.598239635526171	NA	NA	NA	NA	0.652361096373105	0.553236642427503	0.632737666087569	0.563741604964772	NA	NA	p.Phe197Thr	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.175	-3.979	2.804	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197V	197	F	V	missense	low	0.451983636863923	0.187899793120707	4	0.0939498965603537	0.267845223254366	0.636122050473479	NA	NA	NA	NA	0.32901988135406	0.254274877438285	0.600180554889791	0.624459233773555	0.58164290334327	NA	NA	NA	NA	0.554093902177731	0.528866768633797	0.60919190450881	0.612100159472713	NA	NA	p.Phe197Val	1	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.175	-3.307	2.132	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197W	197	F	W	missense	possibly_low	0.694479853300239	0.383157659149026	8	0.13546668952392	0.428970020728486	0.959989685871991	1.06696315049778	1.16531526380022	0.00227501279429583	0.604908687299908	0.845966861758323	0.912802105733933	0.388186435620315	0.569421308897133	0.614700606971839	0.700542252421812	0.709282489403713	0.419201932392091	0.593480460849407	0.629679165083326	0.655390739459164	0.565583638428343	0.599722048860353	NA	NA	p.Phe197Trp	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.175	-5.04	3.865	0.00383338	NA	NA	NA	NA	NA	NA	NA
F197X	197	F	X	nonsense	low	-0.414679810853551	0.277120425565259	4	0.138560212782629	-0.68625283759771	-0.143106784109391	NA	NA	NA	NA	-0.701190762576171	-0.602150640558544	-0.197986565156865	-0.157391275122622	0.419861378269983	NA	NA	NA	NA	0.403461931547562	0.364320258486334	0.445004877681758	0.436260824992405	NA	NA	p.Phe197Ter	0	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F197Y	197	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe197Tyr	1	31.1	5.8	10.6	0.421	16.6	-101.3	-87.4	161.3	0	-4.9	0	0	13.77	0	0	0	0	6	12.56190341719	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.175	-2.221	1.046	0.00383338	NA	NA	NA	NA	NA	NA	NA
Y198A	198	Y	A	missense	possibly_wt-like	0.849119791199558	0.182153623540783	4	0.0910768117703915	0.670612520302858	1.02762706209626	NA	NA	NA	NA	0.90133582579287	0.586311400845066	1.00719140486812	0.90164053329218	0.656106783198676	NA	NA	NA	NA	0.637774923182327	0.592661517879328	0.69291610169246	0.674438643215024	NA	NA	p.Tyr198Ala	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.56	-1.999	-0.561	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198C	198	Y	C	missense	possibly_low	0.66954287838451	0.113733809996344	4	0.0568669049981722	0.558085792675832	0.780999964093189	NA	NA	NA	NA	0.758580907537042	0.594542825315987	0.774672959948406	0.550374820736607	0.6061702584802	NA	NA	NA	NA	0.616902051424772	0.594243035643302	0.645085877676736	0.595438465535629	NA	NA	p.Tyr198Cys	1	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.56	-2.74	0.18	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198D	198	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr198Asp	1	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.56	-3.253	0.693	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198E	198	Y	E	missense	low	0.453037522120247	0.177353301222042	4	0.088676650611021	0.279234480653004	0.62684056358749	NA	NA	NA	NA	0.227909267881034	0.41559685355248	0.521844682719916	0.64679928432756	0.576469827955241	NA	NA	NA	NA	0.539310041179204	0.559861837815962	0.593077818094521	0.617124469845317	NA	NA	p.Tyr198Glu	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.56	-3.372	0.812	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198F	198	Y	F	missense	wt-like	1.38093734516618	0.461412065074983	4	0.230706032537491	0.928761830376571	1.83311285995579	NA	NA	NA	NA	1.78120192189811	1.69429900933955	1.27478815468359	0.773460294743472	0.757193208723849	NA	NA	NA	NA	0.766424306420481	0.805541085843201	0.747962111027217	0.645610718204458	NA	NA	p.Tyr198Phe	1	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.56	-2.976	0.416	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198G	198	Y	G	missense	possibly_wt-like	0.760625816298334	0.100164530060728	4	0.0500822650303639	0.662466380574631	0.858785252022037	NA	NA	NA	NA	0.881158651254793	0.636869873215477	0.751059103883817	0.773415636839249	0.637526555361424	NA	NA	NA	NA	0.63482472306517	0.602375404273555	0.640228387657678	0.645600674575825	NA	NA	p.Tyr198Gly	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.56	-3.342	0.782	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198H	198	Y	H	missense	possibly_low	0.55707550312981	0.390461437328198	3	0.225433015949603	0.115234910942343	0.998916095317276	NA	NA	NA	NA	0.880409207152107	0.123284376341826	NA	0.667532925895496	0.621787496463802	NA	NA	NA	NA	0.63471514329842	0.503699337999193	NA	0.621787496463802	NA	NA	p.Tyr198His	1	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.56	-3.429	0.869	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198I	198	Y	I	missense	wt-like	1.13808083640798	0.298640474750888	3	0.172420158488343	0.800143535562135	1.47601813725382	NA	NA	NA	NA	1.47410795807638	0.902981783201185	NA	1.03715276794636	0.704915544981287	NA	NA	NA	NA	0.721522645569236	0.653503943973357	NA	0.704915544981287	NA	NA	p.Tyr198Ile	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.56	-3.667	1.107	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198K	198	Y	K	missense	wt-like	1.2134439275147	0.0680510765177625	3	0.039289307346174	1.13643830013868	1.29044955489073	NA	NA	NA	NA	1.13921536293386	1.22823021917839	NA	1.27288620043186	0.715994486287123	NA	NA	NA	NA	0.672556415358957	0.715994486287123	NA	0.757932342196817	NA	NA	p.Tyr198Lys	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.56	-3.558	0.998	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198L	198	Y	L	missense	wt-like	1.35120781252396	0.293333335537359	4	0.14666666776868	1.06374642596484	1.63866919908307	NA	NA	NA	NA	1.65385583143701	1.53677743251254	1.18748306652792	1.02671491961835	0.738903721810972	NA	NA	NA	NA	0.747804432250843	0.775276193923077	0.730003011371102	0.70256805747246	NA	NA	p.Tyr198Leu	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.56	-3.027	0.467	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198M	198	Y	M	missense	wt-like	1.1731039998318	0.251186602677931	4	0.125593301338965	0.926945652507942	1.41926234715566	NA	NA	NA	NA	1.42428198475505	1.29160276926401	0.84024309350361	1.13628815180454	0.720724296810955	NA	NA	NA	NA	0.714237354357989	0.728170363507741	0.658573986879295	0.727211239263921	NA	NA	p.Tyr198Met	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.56	-5.01	2.45	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198N	198	Y	N	missense	wt-like	1.11508390163654	0.139423840778044	4	0.0697119203890222	0.97845104838093	1.25171675489214	NA	NA	NA	NA	1.26810517401491	1.11990658616788	1.14204132788123	0.930282518482132	0.693292042143914	NA	NA	NA	NA	0.691402004221464	0.695182080066364	0.720655415141108	0.680880267997115	NA	NA	p.Tyr198Asn	1	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.56	-2.697	0.137	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198P	198	Y	P	missense	wt-like	1.29647089898954	0.248508617085868	4	0.124254308542934	1.05293692932146	1.54000486865762	NA	NA	NA	NA	1.45645892318524	0.97428300195617	1.23143050893639	1.52371116188037	0.728992659994451	NA	NA	NA	NA	0.718942096706695	0.667203169964235	0.739043223282208	0.814343246570882	NA	NA	p.Tyr198Pro	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.56	-3.234	0.674	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198Q	198	Y	Q	missense	low	0.324680214584093	0.170253696103178	4	0.0851268480515889	0.157834658285565	0.491525770882621	NA	NA	NA	NA	0.150811698635887	0.273986350425199	0.557262491767612	0.316660317507675	0.537764848194219	NA	NA	NA	NA	0.528037240946926	0.532653967895969	0.600363441140393	0.542875728492468	NA	NA	p.Tyr198Gln	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.56	-4.395	1.835	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198R	198	Y	R	missense	possibly_wt-like	0.841876190674853	0.126759120579511	4	0.0633795602897555	0.717654535150947	0.966097846198759	NA	NA	NA	NA	0.911641133246629	0.969209484199564	0.805370814302166	0.681283330951053	0.645341146507567	NA	NA	NA	NA	0.639281710924091	0.666228386257448	0.651400582091043	0.624879982874302	NA	NA	p.Tyr198Arg	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.56	-4.324	1.764	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198S	198	Y	S	missense	possibly_low	0.598940196766571	0.313476305864777	4	0.156738152932389	0.291739062015758	0.906141331517383	NA	NA	NA	NA	0.428961540578551	0.243622961893582	0.832508807058604	0.890667477535544	0.612844924878783	NA	NA	NA	NA	0.56870684484701	0.526820197750008	0.656983004910557	0.671970786764836	NA	NA	p.Tyr198Ser	1	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.56	-1.681	-0.879	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198T	198	Y	T	missense	possibly_wt-like	0.849777947636556	0.166925175591867	4	0.0834625877959335	0.686194281500014	1.0133616137731	NA	NA	NA	NA	0.700917573196707	0.72233431032193	0.928689774948212	1.04717013207938	0.647781875936658	NA	NA	NA	NA	0.608470822592138	0.618795833805451	0.676767918067866	0.707168464973476	NA	NA	p.Tyr198Thr	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.56	-3.284	0.724	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198V	198	Y	V	missense	wt-like	1.35721696946985	0.163785717376686	4	0.081892858688343	1.19670991584967	1.51772402309004	NA	NA	NA	NA	1.58753150232946	1.21453430239548	1.27318608805377	1.35361598510072	0.742869698101514	NA	NA	NA	NA	0.73810683841112	0.713363066201498	0.747632557791907	0.77608859003114	NA	NA	p.Tyr198Val	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.56	-3.332	0.772	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198W	198	Y	W	missense	possibly_wt-like	0.732594383584668	0.199808530300722	4	0.099904265150361	0.53678562198802	0.928403145181315	NA	NA	NA	NA	0.53308744610531	0.648936682536067	1.00239060817748	0.745962797519819	0.622060155796352	NA	NA	NA	NA	0.583931585957537	0.604693821135961	0.691928553451947	0.639426490456742	NA	NA	p.Tyr198Trp	0	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.56	-5.599	3.039	0.007376956	NA	NA	NA	NA	NA	NA	NA
Y198X	198	Y	X	nonsense	low	0.0428783302759895	0.204769020940984	4	0.102384510470492	-0.157791622820938	0.243548283372917	NA	NA	NA	NA	-0.198159898950798	-0.0562650505723206	0.213445569949941	0.212492700677135	0.498230365391432	NA	NA	NA	NA	0.477012453202643	0.469202197294181	0.529638555651785	0.51944827758022	NA	NA	p.Tyr198Ter	1	34.8	6.6	10.9	0.779	35	-178.4	-90	117.7	26.6666666666667	-0.4	0	0	13.73	0	0	0	0	3	15.636414934641	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V199A	199	V	A	missense	low	0.526553389709489	0.0778265577160867	4	0.0389132788580433	0.45028476462736	0.602822014791618	NA	NA	NA	NA	0.548731384886568	0.436016783855307	0.50095925211021	0.620506137985871	0.587500269635727	NA	NA	NA	NA	0.586218960234751	0.563785154202708	0.588781579036703	0.611211102390146	NA	NA	p.Val199Ala	1	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.183	-2.696	1.513	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199C	199	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val199Cys	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.183	-5.088	3.905	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199D	199	V	D	missense	low	-0.188303614221761	0.240902214601145	4	0.120451107300573	-0.424383446428853	0.0477762179853311	NA	NA	NA	NA	-0.358769284249287	-0.343387028018254	-0.209921477409815	0.158863332790313	0.448039400522338	NA	NA	NA	NA	0.453528995376081	0.414036957138945	0.442549805668595	0.507386953515685	NA	NA	p.Val199Asp	1	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.183	-4.314	3.131	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199E	199	V	E	missense	low	0.292826062465775	0.241361491426806	4	0.120680745713403	0.0562961472400684	0.529355977691482	NA	NA	NA	NA	-0.0357959019713571	0.259783766800746	0.485519923005278	0.461796462028434	0.552721131421193	NA	NA	NA	NA	0.500752461101514	0.529925201037238	0.585605630694212	0.575517061805148	NA	NA	p.Val199Glu	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.183	-4.12	2.937	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199F	199	V	F	missense	possibly_low	0.695658066064864	0.368670361210856	4	0.184335180605428	0.334367750994539	1.05694838113519	NA	NA	NA	NA	0.82829562255127	0.222685267591511	0.632862731043361	1.09878864307331	0.621505081804677	NA	NA	NA	NA	0.627095369622739	0.522797402474128	0.615914793986616	0.718777544352158	NA	NA	p.Val199Phe	1	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.183	-3.025	1.842	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199G	199	V	G	missense	low	-0.0372393543214849	0.253732107227526	4	0.126866053613763	-0.285892250265188	0.211413541622218	NA	NA	NA	NA	-0.279778971342259	-0.232097081173958	0.199989414241712	0.162929220988566	0.486689960194456	NA	NA	NA	NA	0.465078542610894	0.435419286346695	0.526870556140446	0.508301377778018	NA	NA	p.Val199Gly	1	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.183	-4.015	2.832	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199H	199	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val199His	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.183	-5.258	4.075	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199I	199	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val199Ile	1	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.183	-1.892	0.709	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199K	199	V	K	missense	low	0.375304719799187	0.339593707470632	4	0.169796853735316	0.042509001789752	0.708100437808622	NA	NA	NA	NA	0.62295127563473	-0.0968883389862995	0.622607581147369	0.352548361400948	0.57400900203278	NA	NA	NA	NA	0.597071001484005	0.461397174908966	0.613805257614095	0.550947002581555	NA	NA	p.Val199Lys	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.183	-4.112	2.929	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199L	199	V	L	missense	wt-like	1.14411487050529	0.174678810990703	4	0.0873394054953513	0.97293278130326	1.31529695970732	NA	NA	NA	NA	1.38613165671597	1.08957709364235	0.971580132341468	1.12917059932136	0.699007018440935	NA	NA	NA	NA	0.708659214463424	0.689354822418446	0.685590682227252	0.725610491195677	NA	NA	p.Val199Leu	1	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.183	-2.202	1.019	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199M	199	V	M	missense	possibly_low	0.540977504429464	0.440172390754645	3	0.254133648292036	0.0428847065173054	1.03907030234162	NA	NA	NA	NA	0.944457591852837	0.606921225395953	0.0715536960396023	NA	0.596621318975088	NA	NA	NA	NA	0.644079960542343	0.596621318975088	0.500450677169775	NA	NA	NA	p.Val199Met	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.183	-3.145	1.962	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199N	199	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val199Asn	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.183	-4.461	3.278	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199P	199	V	P	missense	wt-like	1.0297290913693	0.265215446763475	4	0.132607723381737	0.769822729469247	1.28963545326936	NA	NA	NA	NA	1.1686229971541	0.727838356972102	0.902296675066473	1.32015833628454	0.674097484067138	NA	NA	NA	NA	0.6768562446417	0.619853335770237	0.671338723492576	0.768563915385321	NA	NA	p.Val199Pro	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.183	-4.371	3.188	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199Q	199	V	Q	missense	low	0.322433355446321	0.328071727055945	4	0.164035863527972	0.000928970758567849	0.643937740134074	NA	NA	NA	NA	0.00385374324016892	0.077769717332788	0.642254651001974	0.565855310210354	0.552734936869261	NA	NA	NA	NA	0.506549823250883	0.494954528155126	0.617846759580629	0.598920050487638	NA	NA	p.Val199Gln	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.183	-3.738	2.555	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199R	199	V	R	missense	low	0.198105399889623	0.286104549151072	4	0.143052274575536	-0.0822719061849624	0.478482705964208	NA	NA	NA	NA	-0.00900109728770519	-0.0871608150504968	0.437885479473528	0.450698032423165	0.538845632405762	NA	NA	NA	NA	0.504670256220336	0.463266140840477	0.575806983942662	0.573021008591187	NA	NA	p.Val199Arg	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.183	-4.455	3.272	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199S	199	V	S	missense	low	0.355666689560872	0.320218426205967	4	0.160109213102984	0.0418583982859764	0.669474980835769	NA	NA	NA	NA	-0.0207859538154154	0.223170892306754	0.513100879887366	0.707180939864785	0.557084939934708	NA	NA	NA	NA	0.502947136610942	0.52289070638726	0.591279173482157	0.630704393377598	NA	NA	p.Val199Ser	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.183	-3.922	2.739	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199T	199	V	T	missense	possibly_wt-like	0.765274733742226	0.123717683329544	4	0.061858841664772	0.644033631953907	0.886515835530545	NA	NA	NA	NA	0.888235090110017	0.596850408026848	0.76156143036602	0.814452006466019	0.639124086083234	NA	NA	NA	NA	0.635859402658209	0.594686395484841	0.64238876950826	0.654829814728009	NA	NA	p.Val199Thr	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.183	-2.718	1.535	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199V	199	V	V	synonymous	wt-like	1.17317929668538	0.239831017706082	4	0.119915508853041	0.938149218145622	1.40820937522513	NA	NA	NA	NA	1.12916358638837	0.895080788042579	1.47811448453747	1.19035832777309	0.705229199643804	NA	NA	NA	NA	0.671086697570363	0.651985912162393	0.789787368840912	0.739371701717244	NA	NA	p.Val199=	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199W	199	V	W	missense	low	0.0342946302379653	0.202187368721638	4	0.101093684360819	-0.1638453501737	0.232434610649631	NA	NA	NA	NA	-0.140930402172059	-0.134036512769756	0.253950623542872	0.158194812350803	0.496308425437397	NA	NA	NA	NA	0.485380248593562	0.454259832284337	0.537970650715416	0.507236602281232	NA	NA	p.Val199Trp	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.183	-5.619	4.436	0.005375338	NA	NA	NA	NA	NA	NA	NA
V199X	199	V	X	nonsense	low	0.315695686911652	0.282548820488811	4	0.141274410244405	0.0388029308954814	0.592588442927823	NA	NA	NA	NA	0.180146972207047	0.000248939630493567	0.441386228572693	0.641000607236376	0.554426797916781	NA	NA	NA	NA	0.532326490036938	0.480060327589191	0.576527105796624	0.615820338801111	NA	NA	p.Val199Ter	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V199Y	199	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val199Tyr	0	35.5	10.3	10.4	0.911	14.3	-161.7	-116.3	93.8	1.21212121212121	-1.4	0	0	15.5	0	0	0	0	4	15.8986059768857	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.183	-4.33	3.147	0.005375338	NA	NA	NA	NA	NA	NA	NA
P200A	200	P	A	missense	possibly_low	0.716389105661076	0.229104427234976	4	0.114552213617488	0.491870892621461	0.940907318700692	NA	NA	NA	NA	0.508583016125806	0.981586153754168	0.833135727420132	0.542251525344199	0.625361745005746	NA	NA	NA	NA	0.580348677356534	0.668606337100414	0.657111965610179	0.593611524401314	NA	NA	p.Pro200Ala	1	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.998	-2.722	0.724	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200C	200	P	C	missense	possibly_wt-like	1.19147441978006	0.55373388935973	4	0.276866944679865	0.648825179697878	1.73412365986224	NA	NA	NA	NA	0.411237446892167	1.30867969814715	1.71990564933503	1.32607488474588	0.75067296957375	NA	NA	NA	NA	0.566115321283025	0.731451383272694	0.839525038389163	0.769894555874807	NA	NA	p.Pro200Cys	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.998	-4.436	2.438	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200D	200	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Asp	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.998	-2.528	0.53	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200E	200	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Glu	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.998	-2.843	0.845	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200F	200	P	F	missense	low	0.141102017917565	0.193077570502566	3	0.111473387304136	-0.0773818064332259	0.359585842268355	NA	NA	NA	NA	-0.0599988508966409	0.158299116141871	0.325005788507464	NA	0.510426780277297	NA	NA	NA	NA	0.497213633471303	0.510426780277297	0.552587058712228	NA	NA	NA	p.Pro200Phe	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.998	-4.118	2.12	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200G	200	P	G	missense	wt-like	1.27719828778894	0.0677437546623673	4	0.0338718773311837	1.21081062813107	1.34358594744682	NA	NA	NA	NA	1.2458508561911	1.34650807083358	1.31846896402923	1.19796526010188	0.739900962860033	NA	NA	NA	NA	0.688148095160651	0.738719413684338	0.756947475164292	0.741082512035728	NA	NA	p.Pro200Gly	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.998	-2.539	0.541	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200H	200	P	H	missense	wt-like	1.543307203209	0.245007211832493	4	0.122503605916247	1.30320454763687	1.78340985878114	NA	NA	NA	NA	1.38059228856093	1.82650865669752	1.30120149701034	1.66492637056722	0.792169111362716	NA	NA	NA	NA	0.707849277247035	0.830942753149267	0.753395469576165	0.846102755622108	NA	NA	p.Pro200His	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.998	-3.681	1.683	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200I	200	P	I	missense	possibly_wt-like	0.788856489986528	0.119793730989038	4	0.0598968654945188	0.671460790830431	0.906252189142625	NA	NA	NA	NA	0.944566174560959	0.703213837658326	0.686678541179659	0.820967406547168	0.635540408074599	NA	NA	NA	NA	0.644095836933639	0.61512218445352	0.626984979215558	0.656295137831475	NA	NA	p.Pro200Ile	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.998	-4.351	2.353	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200K	200	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Lys	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.998	-3.522	1.524	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200L	200	P	L	missense	low	0.308023107675344	0.143633650600529	4	0.0718168253002646	0.167264716602821	0.448781498747868	NA	NA	NA	NA	0.312055082752435	0.114583117353631	0.459818673151528	0.345635557443784	0.550502850749231	NA	NA	NA	NA	0.551613398739174	0.502027550120026	0.580318753180416	0.549392302759288	NA	NA	p.Pro200Leu	1	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.998	-2.756	0.758	0.009074077	NA	NA	NA	NA	8.12e-06	NA	NA
P200M	200	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Met	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.998	-4.325	2.327	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200N	200	P	N	missense	wt-like	1.74935875214406	0.400242726452187	3	0.23108024585836	1.29644979272301	2.2022677115651	NA	NA	NA	NA	2.11696447654897	1.80813322527291	NA	1.3229785546103	0.815517737524949	NA	NA	NA	NA	0.815517737524949	0.827412249854075	NA	0.769198186653099	NA	NA	p.Pro200Asn	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.998	-2.909	0.911	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200P	200	P	P	synonymous	possibly_low	0.717037288389561	0.105659895586171	4	0.0528299477930853	0.613492493409983	0.82058208336914	NA	NA	NA	NA	0.739833159378445	0.566699384921612	0.814255416822194	0.747361192435995	0.626950923019136	NA	NA	NA	NA	0.61416085449903	0.588893427474095	0.653228189913598	0.639740991539243	NA	NA	p.Pro200=	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200Q	200	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Gln	1	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.998	-3.336	1.338	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200R	200	P	R	missense	wt-like	1.2385596717476	0.0494396653560061	4	0.024719832678003	1.19010968999486	1.28700965350034	NA	NA	NA	NA	1.18222065334483	1.2421251188716	1.30205116875227	1.2278417460217	0.733232957578895	NA	NA	NA	NA	0.678844422263461	0.718664137302093	0.753570251365069	0.747801777855697	NA	NA	p.Pro200Arg	1	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.998	-3.45	1.452	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200S	200	P	S	missense	wt-like	1.06257567605032	0.188544057124207	4	0.0942720285621034	0.877805895319064	1.24734545678157	NA	NA	NA	NA	1.23911197738297	1.20051508110936	0.846148489697912	0.964527156011031	0.687872354692817	NA	NA	NA	NA	0.687162771818588	0.710669529064712	0.659788756842911	0.688581937567047	NA	NA	p.Pro200Ser	1	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.998	-2.161	0.163	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200T	200	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Thr	1	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.998	-2.371	0.373	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200V	200	P	V	missense	possibly_low	0.574417373622798	0.319059504922668	4	0.159529752461334	0.261744804335994	0.887089942909603	NA	NA	NA	NA	0.804584283825062	0.102090009826347	0.697246208303464	0.693748992536319	0.625655975612593	NA	NA	NA	NA	0.623628422644806	0.499627227848779	0.629158801967683	0.627683528580379	NA	NA	p.Pro200Val	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.998	-3.306	1.308	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200W	200	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Trp	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.998	-5.914	3.916	0.009074077	NA	NA	NA	NA	NA	NA	NA
P200X	200	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Ter	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P200Y	200	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro200Tyr	0	39.3	10.9	10.7	0.315	33.9	-100.4	-78.5	164.3	26.6233766233766	-3	0	0	17.61	0	0	0	0	5	19.5654700291818	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.998	-4.117	2.119	0.009074077	NA	NA	NA	NA	NA	NA	NA
H201A	201	H	A	missense	wt-like	1.03009897509813	0.234007108536509	4	0.117003554268255	0.80077622266917	1.25942172752708	NA	NA	NA	NA	1.14788953192309	1.30223924336729	0.847782978877831	0.822484146224301	0.666974843096327	NA	NA	NA	NA	0.673824706631352	0.730213967600789	0.660124979561301	0.656636254825545	NA	NA	p.His201Ala	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-3.142	-2.398	-0.744	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201C	201	H	C	missense	possibly_low	0.660835127938795	0.161466675034144	4	0.080733337517072	0.502600694053617	0.819069561823972	NA	NA	NA	NA	0.624365635636141	0.786395230869572	0.785332021013033	0.447247624236433	0.614190885288915	NA	NA	NA	NA	0.597277801749027	0.631103968828802	0.647278500626259	0.572245006692695	NA	NA	p.His201Cys	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-3.142	-4.2	1.058	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201D	201	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His201Asp	1	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-3.142	-2.131	-1.011	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201E	201	H	E	missense	wt-like	1.04222904840106	0.119676308840206	4	0.0598381544201031	0.924948420836314	1.15950967596581	NA	NA	NA	NA	1.09397740232854	1.11939104407239	1.09184940091979	0.863698346283526	0.680512493630675	NA	NA	NA	NA	0.665941959185922	0.695083028075427	0.710330681070333	0.665905389304698	NA	NA	p.His201Glu	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-3.142	-2.127	-1.015	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201F	201	H	F	missense	wt-like	0.971788222388275	0.0497510417895115	2	0.0351792990204589	0.902838063306811	1.04073838146974	NA	NA	NA	NA	0.936608923367816	1.00696752140873	NA	NA	0.658207636297775	NA	NA	NA	NA	0.642932369602871	0.673482902992679	NA	NA	NA	NA	p.His201Phe	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-3.142	-3.747	0.605	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201G	201	H	G	missense	wt-like	1.0114321127929	0.0693248318373566	4	0.0346624159186783	0.94349502597514	1.07936919961065	NA	NA	NA	NA	1.05304763326868	1.07808212993315	0.99181750790564	0.922781180064114	0.683169740571821	NA	NA	NA	NA	0.659957424074342	0.687146275238483	0.689753613073702	0.679193205905158	NA	NA	p.His201Gly	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-3.142	-2.997	-0.145	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201I	201	H	I	missense	possibly_low	0.246935547334857	0.428867128644651	3	0.247606552169571	-0.23836437725364	0.732235471923355	NA	NA	NA	NA	-0.0904925630733596	0.729550409740322	NA	0.10174879533761	0.494541809667134	NA	NA	NA	NA	0.492755003593937	0.62018227541797	NA	0.494541809667134	NA	NA	p.His201Ile	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-3.142	-3.622	0.48	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201K	201	H	K	missense	wt-like	1.78645104175343	0.141821693386629	4	0.0709108466933145	1.64746833612129	1.92543374738557	NA	NA	NA	NA	1.99414866904945	1.74883530649211	1.72712978879854	1.67569040267361	0.82851515955029	NA	NA	NA	NA	0.797560257453096	0.816019238565471	0.84101108053511	0.848523602344563	NA	NA	p.His201Lys	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-3.142	-3	-0.142	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201L	201	H	L	missense	wt-like	1.21273617804153	0.112529378349338	4	0.0562646891746689	1.10245941365784	1.32301294242523	NA	NA	NA	NA	1.2973984517639	1.13164350363481	1.10086393695384	1.32103881981359	0.704811065557338	NA	NA	NA	NA	0.695685112903699	0.697437114238617	0.712185016876058	0.768761937431743	NA	NA	p.His201Leu	1	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-3.142	-3.188	0.046	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201M	201	H	M	missense	possibly_wt-like	0.999777387081302	0.414544094708307	4	0.207272047354153	0.593531639265281	1.40602313489732	NA	NA	NA	NA	0.602198647099564	1.36965505570921	1.34550018768889	0.681755657827544	0.684076446825341	NA	NA	NA	NA	0.594036661516324	0.743166683764088	0.762507935038808	0.624986209886594	NA	NA	p.His201Met	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-3.142	-4.365	1.223	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201N	201	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His201Asn	1	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-3.142	-3.261	0.119	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201P	201	H	P	missense	wt-like	1.21790360404978	0.0925953383890768	4	0.0462976691945384	1.12716183986034	1.30864536823923	NA	NA	NA	NA	1.31752873235353	1.27592973913892	1.14020294047646	1.13795300423022	0.722718163376445	NA	NA	NA	NA	0.698628456434867	0.725159077229687	0.720277249523203	0.727585667033946	NA	NA	p.His201Pro	1	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-3.142	-2.716	-0.426	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201Q	201	H	Q	missense	wt-like	1.37866894039615	0.160848074757705	4	0.0804240373788524	1.2210407236423	1.53629715715001	NA	NA	NA	NA	1.51717745042352	1.51752410949601	1.25850248463275	1.22147171703234	0.745490607491498	NA	NA	NA	NA	0.727820039742471	0.771577019803976	0.744612066057466	0.74636914892553	NA	NA	p.His201Gln	1	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-3.142	-2.897	-0.245	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201R	201	H	R	missense	wt-like	1.03387869127482	0.0550653763782969	4	0.0275326881891484	0.979915614026518	1.08784176852312	NA	NA	NA	NA	1.05142122942034	1.10404220029261	0.993168360031636	0.9868829753547	0.691082759244592	NA	NA	NA	NA	0.659719619875599	0.692134028278376	0.690031490210807	0.693609794363741	NA	NA	p.His201Arg	1	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-3.142	-3.121	-0.021	0.009955286	NA	NA	NA	NA	7.22e-06	NA	NA
H201S	201	H	S	missense	wt-like	0.979519835854162	0.1960891459359	4	0.0980445729679501	0.787356003957371	1.17168366775095	NA	NA	NA	NA	1.15747328973847	1.13224089206448	0.867515923516198	0.760849238097506	0.66970506979727	NA	NA	NA	NA	0.675225993187921	0.697551891506737	0.664184146406619	0.642774472934437	NA	NA	p.His201Ser	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-3.142	-2.759	-0.383	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201T	201	H	T	missense	possibly_wt-like	0.759554134635434	0.152224200104459	4	0.0761121000522294	0.610377159745356	0.908731109525513	NA	NA	NA	NA	0.642160750343544	0.614621422857343	0.903414295212532	0.878020070128318	0.634503037893648	NA	NA	NA	NA	0.599879709632389	0.598100771178569	0.671568623627892	0.669126366154907	NA	NA	p.His201Thr	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-3.142	-3.015	-0.127	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201V	201	H	V	missense	wt-like	1.43259270846469	0.0801471533268956	4	0.0400735766634478	1.35404994147263	1.51113547545675	NA	NA	NA	NA	1.51849362977756	1.45938786768574	1.42535447595179	1.32713486044368	0.76527007474405	NA	NA	NA	NA	0.728012484550696	0.760407203512954	0.778934367348509	0.770132945975146	NA	NA	p.His201Val	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-3.142	-3.34	0.198	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201W	201	H	W	missense	wt-like	1.02864001656403	0.0755485693037355	4	0.0377742846518678	0.954603779104609	1.10267625402346	NA	NA	NA	NA	1.11108436907269	1.0544472003835	1.01810598738549	0.930922509414462	0.68181472920559	NA	NA	NA	NA	0.668443249700982	0.682605255507924	0.695161286701435	0.681024202903256	NA	NA	p.His201Trp	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-3.142	-4.571	1.429	0.009955286	NA	NA	NA	NA	NA	NA	NA
H201X	201	H	X	nonsense	low	-0.659649513291283	0.384877546802037	4	0.192438773401019	-1.03682257838634	-0.282476448196222	NA	NA	NA	NA	-1.14837379855212	-0.779226589698279	-0.299700980402694	-0.411296684512036	0.358617154115539	NA	NA	NA	NA	0.338077184905398	0.330298351327209	0.42408170632425	0.379157123325679	NA	NA	p.His201Ter	0	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H201Y	201	H	Y	missense	wt-like	1.11136982586285	0.275396891991158	4	0.137698445995579	0.841485830984386	1.38125382074132	NA	NA	NA	NA	0.884913250208155	0.889601414534927	1.22012696413124	1.4508376745771	0.693825588723932	NA	NA	NA	NA	0.635373700735516	0.650933150690984	0.73671802675688	0.797953891620204	NA	NA	p.His201Tyr	1	41	14.2	11.3	0.863	122.7	57.1	-50.4	-44.5	30.5555555555556	-3.3	1	0	17.22	2	39	0	0	5	21.4541205876653	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-3.142	-3.725	0.583	0.009955286	NA	NA	NA	NA	NA	NA	NA
A202A	202	A	A	synonymous	wt-like	1.4189505151115	0.197765618891528	4	0.0988828094457642	1.22514376990767	1.61275726031534	NA	NA	NA	NA	1.69586344656267	1.41803121886334	1.24513568528227	1.31677170973773	0.753203921831238	NA	NA	NA	NA	0.753946564333376	0.752461279329099	0.741862447602347	0.767802258071872	NA	NA	p.Ala202=	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202C	202	A	C	missense	wt-like	1.03322802215844	0.119950296431321	4	0.0599751482156605	0.915678891688295	1.15077715262859	NA	NA	NA	NA	1.19027094377316	1.05205883760362	0.908675881483103	0.981906425773884	0.6810839342767	NA	NA	NA	NA	0.680021493300834	0.682146375252565	0.672650958623235	0.692490561011147	NA	NA	p.Ala202Cys	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.124	-4.167	2.043	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202D	202	A	D	missense	possibly_low	0.644354622140438	0.245192575275912	4	0.122596287637956	0.404070313731731	0.884638930549145	NA	NA	NA	NA	0.946048849450463	0.469144232834513	0.421988492283705	0.740236913993071	0.605337811901238	NA	NA	NA	NA	0.644312625841544	0.570149988044145	0.572536893009761	0.638138730792716	NA	NA	p.Ala202Asp	1	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.124	-2.167	0.043	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202E	202	A	E	missense	wt-like	1.62351263053448	0.242321087482398	4	0.121160543741199	1.38604232845444	1.86098293261452	NA	NA	NA	NA	1.85659910763397	1.69221276859788	1.66179111391782	1.28344753198827	0.791294369176707	NA	NA	NA	NA	0.777448485537903	0.805140252815511	0.82757058355641	0.760307601266133	NA	NA	p.Ala202Glu	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.124	-2.1	-0.024	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202F	202	A	F	missense	wt-like	1.27038577457111	0.189719407802199	4	0.0948597039010994	1.08446417134082	1.4563073778014	NA	NA	NA	NA	1.44588510975759	1.40115711103023	1.03607673658705	1.19842414090957	0.729290882221935	NA	NA	NA	NA	0.717396049436588	0.749219227921892	0.698857961003287	0.741185715007283	NA	NA	p.Ala202Phe	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.124	-4.771	2.647	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202G	202	A	G	missense	wt-like	0.99716193316145	0.0589833770935865	4	0.0294916885467933	0.939359285766463	1.05496458055644	NA	NA	NA	NA	1.02421596455431	1.03727419571446	1.01761833918978	0.909539233187248	0.677760424513455	NA	NA	NA	NA	0.65574180943224	0.679305776536718	0.695060974993047	0.676215072490193	NA	NA	p.Ala202Gly	1	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.124	-2.893	0.769	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202H	202	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala202His	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.124	-3.266	1.142	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202I	202	A	I	missense	possibly_low	0.493261165651363	0.306119491747744	2	0.216459168468209	0.069008991330185	0.91751333997254	NA	NA	NA	NA	0.276801997183154	0.709720334119571	NA	NA	0.581415583598033	NA	NA	NA	NA	0.546458878368625	0.616372288827441	NA	NA	NA	NA	p.Ala202Ile	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.124	-3.932	1.808	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202K	202	A	K	missense	wt-like	1.31987986561442	0.374139997771684	4	0.187069998885842	0.953229405210218	1.68653032601861	NA	NA	NA	NA	1.54837510656553	1.7262249982557	0.978958382388549	1.02596097524789	0.717390045433022	NA	NA	NA	NA	0.732381596596306	0.811675081092954	0.68710842570226	0.702398494269738	NA	NA	p.Ala202Lys	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.124	-2.976	0.852	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202L	202	A	L	missense	possibly_low	0.606783950896139	0.205832851898931	4	0.102916425949466	0.405071462617603	0.808496439174676	NA	NA	NA	NA	0.467717041449655	0.839745100322806	0.403179685894045	0.716493975918052	0.603586189433829	NA	NA	NA	NA	0.574373469923511	0.641354171153326	0.568667826091665	0.632798908944147	NA	NA	p.Ala202Leu	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.124	-3.52	1.396	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202M	202	A	M	missense	wt-like	1.03853879170614	0.111800199684217	4	0.0559000998421085	0.928976609283415	1.14810097412887	NA	NA	NA	NA	0.960584152252789	0.946616594033198	1.18883074045301	1.05812368008556	0.685759754725252	NA	NA	NA	NA	0.646437901208985	0.661887575348735	0.730280234736153	0.70963193410177	NA	NA	p.Ala202Met	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.124	-4.354	2.23	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202N	202	A	N	missense	wt-like	0.884140172934622	0.16090089577674	4	0.0804504478883701	0.7264601925333	1.04182015333594	NA	NA	NA	NA	0.721871764445696	0.990568351404878	1.05071495893447	0.773405616953438	0.657965261648745	NA	NA	NA	NA	0.611534633997498	0.670332102208787	0.701869117620608	0.645598421088704	NA	NA	p.Ala202Asn	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.124	-3.098	0.974	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202P	202	A	P	missense	wt-like	1.19226027816905	0.134354038147017	4	0.0671770190735087	1.06059574019621	1.32392481614189	NA	NA	NA	NA	1.30291241428604	1.28790888923293	1.16487424820357	1.01334556095367	0.71245676583669	NA	NA	NA	NA	0.696491335442345	0.727460651973877	0.725352262715192	0.699561268958188	NA	NA	p.Ala202Pro	1	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.124	-3.152	1.028	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202Q	202	A	Q	missense	possibly_wt-like	0.855148422260868	0.467805077454647	4	0.233902538727323	0.396707870462829	1.31358897405891	NA	NA	NA	NA	0.614897728427052	1.31165416094522	0.318638031407127	1.17540376826407	0.663958163095875	NA	NA	NA	NA	0.59589345425752	0.732022871934231	0.551277178764028	0.73600839919126	NA	NA	p.Ala202Gln	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.124	-2.795	0.671	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202R	202	A	R	missense	wt-like	1.25413021246091	0.129262054869057	4	0.0646310274345287	1.12745572640541	1.38080469851641	NA	NA	NA	NA	1.27117362058184	1.42440832548157	1.20106653806178	1.11987236571845	0.728158252557953	NA	NA	NA	NA	0.691850656306232	0.753686523809581	0.732797200393826	0.723519304722081	NA	NA	p.Ala202Arg	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.124	-3.69	1.566	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202S	202	A	S	missense	wt-like	1.13762866636365	0.0858401191227722	4	0.0429200595613861	1.05350689540902	1.22175043731828	NA	NA	NA	NA	1.21612350195171	1.18558246925364	1.12755480639333	1.02125388785591	0.704570181992886	NA	NA	NA	NA	0.683801518101792	0.70780050062428	0.717675464160385	0.701339863361492	NA	NA	p.Ala202Ser	1	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.124	-2.414	0.29	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202T	202	A	T	missense	wt-like	1.0305576721107	0.185673443132577	4	0.0928367215662886	0.848601041398001	1.2125143028234	NA	NA	NA	NA	1.0768262292451	0.774160393034747	1.21767841145901	1.05356565470395	0.686020516256392	NA	NA	NA	NA	0.663434205052921	0.628753268358492	0.736214347047222	0.708606827459863	NA	NA	p.Ala202Thr	1	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.124	-2.625	0.501	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202V	202	A	V	missense	wt-like	0.975081805019476	0.106351336097554	4	0.0531756680487768	0.870859410790016	1.07930419924894	NA	NA	NA	NA	1.04083287427537	1.08853960109373	0.86706492052928	0.903889824179524	0.669517942431052	NA	NA	NA	NA	0.658171446392229	0.689155487187778	0.664091372803633	0.674944512058471	NA	NA	p.Ala202Val	1	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.124	-3.319	1.195	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202W	202	A	W	missense	wt-like	0.975990894064614	0.0623168159038988	4	0.0311584079519494	0.914921536663187	1.03706025146604	NA	NA	NA	NA	1.0516796297981	0.925471059618526	0.924339952358876	1.00247293448296	0.667815269652679	NA	NA	NA	NA	0.659757401816936	0.657824847393973	0.675873137488422	0.697115999202769	NA	NA	p.Ala202Trp	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.124	-5.921	3.797	0.008787595	NA	NA	NA	NA	NA	NA	NA
A202X	202	A	X	nonsense	possibly_low	0.516475162825562	0.324463243669464	4	0.162231621834732	0.198507026875965	0.834443298775159	NA	NA	NA	NA	0.62282304374416	0.528857087187223	0.842673239684121	0.0715472806867443	0.589337486855905	NA	NA	NA	NA	0.597052252092812	0.581622721618997	0.659073880280203	0.487749444405387	NA	NA	p.Ala202Ter	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A202Y	202	A	Y	missense	wt-like	1.11836519144841	0.139330301220939	4	0.0696651506104697	0.981824005274328	1.25490637762249	NA	NA	NA	NA	1.16628911604727	1.2718111082134	1.09553121838016	0.939829323152802	0.697057704038038	NA	NA	NA	NA	0.676514996846981	0.72436775757475	0.71108804960501	0.683027358471065	NA	NA	p.Ala202Tyr	0	41.8	14.7	7.6	0.829	105.1	52.1	-56	-34.6	54.5454545454545	-3	1	0	17.04	0	0	0	0	6	23.0601584637205	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.124	-3.903	1.779	0.008787595	NA	NA	NA	NA	NA	NA	NA
E203A	203	E	A	missense	wt-like	0.886784984569166	0.104157778700867	4	0.0520788893504333	0.784712237087471	0.988857732050862	NA	NA	NA	NA	0.898890480517624	0.766631267402772	1.01867391636349	0.862944273992776	0.651576587508444	NA	NA	NA	NA	0.637417377684373	0.627306684480304	0.69527811257412	0.665735797332515	NA	NA	p.Glu203Ala	1	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.474	-2.632	1.158	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203C	203	E	C	missense	possibly_wt-like	0.858762321660764	0.197766569907015	4	0.0988832849535077	0.664954644478877	1.05256999884265	NA	NA	NA	NA	0.75323667593099	0.769516691510788	1.15522894708675	0.757066972114522	0.634892450856123	NA	NA	NA	NA	0.616120646046108	0.627861065984933	0.723368175331175	0.641923835727314	NA	NA	p.Glu203Cys	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.474	-5.501	4.027	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203D	203	E	D	missense	possibly_wt-like	1.12427678970739	0.456969161169653	4	0.228484580584826	0.676455240738386	1.57209833867639	NA	NA	NA	NA	1.47160235042861	1.47149705656975	0.508611876572171	1.04539587525901	0.713962860409124	NA	NA	NA	NA	0.721156288824785	0.762733762833887	0.590355762721143	0.706769431993463	NA	NA	p.Glu203Asp	1	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.474	-2.436	0.962	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203E	203	E	E	synonymous	possibly_wt-like	0.742945392084229	0.158259514280693	4	0.0791297571403463	0.587853917983749	0.898036866184709	NA	NA	NA	NA	0.812794437808432	0.818946045095939	0.834104615410144	0.5059364700224	0.631093440465219	NA	NA	NA	NA	0.624828868088637	0.637358012841801	0.657311270786267	0.585444214811127	NA	NA	p.Glu203=	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203F	203	E	F	missense	possibly_wt-like	0.768081596540488	0.232156645877496	4	0.116078322938748	0.540572264194732	0.995590928886244	NA	NA	NA	NA	1.10737777396565	0.604746863107789	0.633149950014216	0.727051799074293	0.625573627677736	NA	NA	NA	NA	0.667901290900041	0.596203555002862	0.61597387638639	0.635173378969082	NA	NA	p.Glu203Phe	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.474	-3.872	2.398	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203G	203	E	G	missense	possibly_low	0.642826989423639	0.110222238502401	4	0.0551111192512005	0.534811180543594	0.750842798303684	NA	NA	NA	NA	0.64111685249325	0.489560186944095	0.742044039344318	0.698586878912891	0.614249326382037	NA	NA	NA	NA	0.599727076390583	0.574072540478033	0.638373943135699	0.628771576373491	NA	NA	p.Glu203Gly	1	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.474	-3.838	2.364	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203H	203	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu203His	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.474	-3.55	2.076	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203I	203	E	I	missense	wt-like	1.14773892819712	0.198188693339489	4	0.0990943466697444	0.95351757765289	1.34196027874134	NA	NA	NA	NA	1.43077863401537	1.02486063103343	1.1376578135408	0.997658634198868	0.705610258064471	NA	NA	NA	NA	0.715187260172242	0.676920736969551	0.719753703997499	0.6960332559567	NA	NA	p.Glu203Ile	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.474	-3.705	2.231	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203K	203	E	K	missense	low	0.595791539044705	0.0722369424912705	4	0.0361184712456353	0.525000636226614	0.666582441862796	NA	NA	NA	NA	0.526210652513233	0.541089808483808	0.664920838322654	0.650944856859126	0.601014915333549	NA	NA	NA	NA	0.582926097442644	0.583973015435169	0.622509309330197	0.61805681523193	NA	NA	p.Glu203Lys	1	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.474	-2.994	1.52	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203L	203	E	L	missense	wt-like	1.26623482062484	0.0572466727441066	4	0.0286233363720533	1.21013411221824	1.32233552903144	NA	NA	NA	NA	1.31802322439829	1.31259440150346	1.22674679905139	1.20757485754623	0.735141641182107	NA	NA	NA	NA	0.698700758455433	0.73220352197245	0.738079760391764	0.743243724697242	NA	NA	p.Glu203Leu	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.474	-3.278	1.804	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203M	203	E	M	missense	wt-like	1.54407977207771	0.188015429112929	4	0.0940077145564644	1.35982803727811	1.7283315068773	NA	NA	NA	NA	1.68518533048598	1.682428444116	1.52257054388477	1.28613476982407	0.779922085431269	NA	NA	NA	NA	0.752385266479655	0.803260373697233	0.79893220583727	0.760911965025268	NA	NA	p.Glu203Met	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.474	-3.608	2.134	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203N	203	E	N	missense	possibly_wt-like	0.853238375413303	0.212599777131538	4	0.106299888565769	0.644894422263775	1.06158232856283	NA	NA	NA	NA	1.147406895688	0.712097647510549	0.683366513052781	0.87008244540188	0.646822430425452	NA	NA	NA	NA	0.673754138104793	0.616829046144676	0.626303678223245	0.66734118262766	NA	NA	p.Glu203Asn	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.474	-3.12	1.646	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203P	203	E	P	missense	low	0.464060144622121	0.0872909493243464	4	0.0436454746621732	0.378516586196106	0.549603703048136	NA	NA	NA	NA	0.458072912568785	0.35356052572388	0.566055847496992	0.478551292698825	0.576124302101401	NA	NA	NA	NA	0.572963356227933	0.547942691279511	0.602172279035088	0.579285247974869	NA	NA	p.Glu203Pro	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.474	-4.281	2.807	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203Q	203	E	Q	missense	wt-like	0.9545326197051	0.219192562643242	4	0.109596281321621	0.739727855475203	1.169337383935	NA	NA	NA	NA	0.96210210197222	0.813256088190867	0.781405941367386	1.26136634728993	0.646565366968594	NA	NA	NA	NA	0.646659847816606	0.636264791619471	0.646470886120581	0.755341510206891	NA	NA	p.Glu203Gln	1	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.474	-2.408	0.934	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203R	203	E	R	missense	low	0.427716107756783	0.203325773557654	4	0.101662886778827	0.228460511105909	0.626971704407658	NA	NA	NA	NA	0.457239773722256	0.132281265144841	0.576739374265059	0.544604017894978	0.583491071254089	NA	NA	NA	NA	0.572841539056852	0.505427925743967	0.604369934703958	0.594140603451327	NA	NA	p.Glu203Arg	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.474	-3.281	1.807	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203S	203	E	S	missense	wt-like	0.826452238952321	0.0561035514786822	4	0.0280517757393411	0.771471768800818	0.881432709103824	NA	NA	NA	NA	0.792892475608166	0.767057593822684	0.888236024329627	0.857622862048809	0.645963799617391	NA	NA	NA	NA	0.621918908069008	0.627388595309799	0.66844637628639	0.664539003924983	NA	NA	p.Glu203Ser	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.474	-3.736	2.262	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203T	203	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu203Thr	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.474	-2.799	1.325	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203V	203	E	V	missense	wt-like	0.975838760410443	0.0789476467209966	4	0.0394738233604983	0.89847148829177	1.05320603252912	NA	NA	NA	NA	0.970864869507332	0.895682548849106	1.08407293586769	0.952734687417637	0.669015661731082	NA	NA	NA	NA	0.647941093501423	0.652101529502812	0.708731022748084	0.685929793959351	NA	NA	p.Glu203Val	1	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.474	-3.074	1.6	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203W	203	E	W	missense	low	0.47869439301252	0.238099804115619	4	0.119049902057809	0.245360872616193	0.712027913408847	NA	NA	NA	NA	0.329364666619114	0.225092153011821	0.646366870395019	0.713953882024126	0.586418489419447	NA	NA	NA	NA	0.554144314861996	0.523259841516303	0.618692663976897	0.632227638074917	NA	NA	p.Glu203Trp	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.474	-3.1	1.626	0.006558229	NA	NA	NA	NA	NA	NA	NA
E203X	203	E	X	nonsense	possibly_low	0.440126884094342	0.3498991146518	4	0.1749495573259	0.097232052624353	0.783021715564331	NA	NA	NA	NA	0.24101569088572	0.139550203930401	0.452849988729531	0.927091652831716	0.56005582635317	NA	NA	NA	NA	0.541226393273545	0.506824519475127	0.578885259432794	0.680162637598464	NA	NA	p.Glu203Ter	1	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E203Y	203	E	Y	missense	wt-like	1.21807819829451	0.184680174515816	4	0.0923400872579078	1.03709495293973	1.3990614436493	NA	NA	NA	NA	1.16656248224174	1.19214868773427	1.03771725391506	1.47588436928699	0.704128751617497	NA	NA	NA	NA	0.676554967011159	0.709062079492667	0.699195423742327	0.803586930261999	NA	NA	p.Glu203Tyr	0	38	14.4	6.8	0.874	107.7	51.3	-70.2	-41.5	12.1495327102804	-4.2	1	0	17.59	1	3	0	0	8	19.7259736298269	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.474	-4.501	3.027	0.006558229	NA	NA	NA	NA	NA	NA	NA
I204A	204	I	A	missense	low	-0.221988142553017	0.290694181732723	4	0.145347090866361	-0.506863205908756	0.0628869208027223	NA	NA	NA	NA	-0.54527737514894	-0.376362192687147	0.0912778349018499	-0.0575908372778298	0.442482428107381	NA	NA	NA	NA	0.426258765315646	0.407701381944391	0.504508032622261	0.458706090899115	NA	NA	p.Ile204Ala	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.615	-2.852	1.237	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204C	204	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Cys	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.615	-5.106	3.491	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204D	204	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Asp	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.615	-4.409	2.794	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204E	204	I	E	missense	low	0.186095025389123	0.140635394367491	4	0.0703176971837453	0.0482748714331885	0.323915179345057	NA	NA	NA	NA	0.167013735887544	0.0529653489069496	0.383985661405812	0.140415355356186	0.516822096789267	NA	NA	NA	NA	0.530406217441024	0.49018882211868	0.564719517855936	0.50323797613751	NA	NA	p.Ile204Glu	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.615	-4.211	2.596	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204F	204	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Phe	1	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.615	-3.558	1.943	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204G	204	I	G	missense	low	0.175994670941858	0.224098203384147	4	0.112049101692073	-0.0436175328746721	0.395606874758387	NA	NA	NA	NA	0.00673470363599857	-0.0384657443569913	0.402475246444276	0.333234478044148	0.526787171889013	NA	NA	NA	NA	0.50697106209586	0.472622008660415	0.568522919322228	0.546603281682167	NA	NA	p.Ile204Gly	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.615	-4.1	2.485	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204H	204	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204His	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.615	-5.274	3.659	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204K	204	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Lys	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.615	-4.15	2.535	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204L	204	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Leu	1	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.615	-1.742	0.127	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204M	204	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Met	1	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.615	-3.169	1.554	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204N	204	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Asn	1	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.615	-4.538	2.923	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204P	204	I	P	missense	low	0.144979677721167	0.288159941528982	4	0.144079970764491	-0.137411875870819	0.427371231313153	NA	NA	NA	NA	-0.125576841524109	-0.0716222854305726	0.460425189425979	0.316692648413371	0.515254082535742	NA	NA	NA	NA	0.487625165310562	0.466251585304768	0.580443516655787	0.542882999760922	NA	NA	p.Ile204Pro	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.615	-4.446	2.831	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204Q	204	I	Q	missense	low	0.203063600251314	0.435690055778091	4	0.217845027889046	-0.223904808622339	0.630032009124967	NA	NA	NA	NA	-0.0996478072362136	-0.23995918411684	0.617849355318215	0.534012037040095	0.541587411677333	NA	NA	NA	NA	0.49141637204516	0.433908726964138	0.612826466415812	0.591758451309506	NA	NA	p.Ile204Gln	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.615	-4.582	2.967	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204R	204	I	R	missense	low	0.0329118148500955	0.216808007450063	4	0.108404003725032	-0.179556128230912	0.245379757931103	NA	NA	NA	NA	-0.110490367533992	-0.191169228042001	0.253522629795657	0.179784225180718	0.500961561572452	NA	NA	NA	NA	0.489831030024134	0.443282825275852	0.537882610229795	0.512092093120769	NA	NA	p.Ile204Arg	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.615	-3.735	2.12	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204S	204	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Ser	1	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.615	-4.017	2.402	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204T	204	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Thr	1	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.615	-3.795	2.18	0.005821857	NA	NA	NA	NA	4.06e-06	NA	NA
I204V	204	I	V	missense	possibly_wt-like	0.879279271691875	0.259561657415329	4	0.129780828707664	0.624913521541092	1.13364502184266	NA	NA	NA	NA	0.645717420525623	1.07656776541219	1.12977880856535	0.665053092264344	0.654042547995474	NA	NA	NA	NA	0.600399747200982	0.686855317774256	0.718132952692685	0.621229778216692	NA	NA	p.Ile204Val	1	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.615	-1.34	-0.275	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204W	204	I	W	missense	low	0.0455002650616538	0.143892543303945	4	0.0719462716519725	-0.0955118361981474	0.186512366321455	NA	NA	NA	NA	0.190141951561223	-0.141705866865535	0.117978057620779	0.0155869179301483	0.492582140037343	NA	NA	NA	NA	0.533787903239566	0.452786306069824	0.510000403923631	0.475163876151056	NA	NA	p.Ile204Trp	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.615	-5.641	4.026	0.005821857	NA	NA	NA	NA	NA	NA	NA
I204X	204	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Ter	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I204Y	204	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile204Tyr	0	37.2	17	9.5	0.938	111.7	48.1	-57	-45.9	0	-5.3	1	0	16.52	0	0	0	0	8	18.8630427317327	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.615	-3.662	2.047	0.005821857	NA	NA	NA	NA	NA	NA	NA
E205A	205	E	A	missense	wt-like	1.07972974322111	0.168983143115598	4	0.0844915715577991	0.914129305970635	1.24533018047158	NA	NA	NA	NA	1.07289984146067	1.31984919018701	0.943721271961785	0.982448669274975	0.686236242827627	NA	NA	NA	NA	0.662860109325109	0.733597397020133	0.679859973279654	0.6926125123756	NA	NA	p.Glu205Ala	1	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.254	-2.786	0.532	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205C	205	E	C	missense	possibly_wt-like	0.861109589952662	0.322313372274596	4	0.161156686137298	0.545248289255732	1.17697089064959	NA	NA	NA	NA	1.1358048538973	1.13238525351384	0.505760210174265	0.670488042225234	0.64725492759734	NA	NA	NA	NA	0.672057748702719	0.697579627920697	0.589769160472547	0.62245210649196	NA	NA	p.Glu205Cys	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.254	-4.205	1.951	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205D	205	E	D	missense	wt-like	1.21233323614823	0.254541509208015	3	0.146959608861181	0.92429769559822	1.50036877669824	NA	NA	NA	NA	1.33765725429715	0.919428316724392	NA	1.37991413742315	0.701571542826086	NA	NA	NA	NA	0.701571542826086	0.656663844791816	NA	0.782003083338776	NA	NA	p.Glu205Asp	1	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.254	-3.068	0.814	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205E	205	E	E	synonymous	wt-like	0.877896826536624	0.157221859029958	4	0.0786109295149792	0.723822235896048	1.0319714171772	NA	NA	NA	NA	0.959265318095832	0.661168512992495	1.02108503129974	0.870068443758431	0.656791550933417	NA	NA	NA	NA	0.64624506822947	0.607043943793478	0.69577409115151	0.667338033637363	NA	NA	p.Glu205=	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205F	205	E	F	missense	possibly_wt-like	0.96495594901125	0.370870540238115	4	0.185435270119057	0.601509498114442	1.32840239990806	NA	NA	NA	NA	1.099961278498	0.670902328462413	1.42872788090999	0.660232308174602	0.643481233387277	NA	NA	NA	NA	0.666816890021401	0.608914118528277	0.779628293866476	0.620145576753154	NA	NA	p.Glu205Phe	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.254	-4.108	1.854	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205G	205	E	G	missense	wt-like	0.937373418648661	0.265506449730677	7	0.100352005353006	0.740687102380398	1.13405973491692	1.08370646125547	0.736929472692771	0.424632407156362	NA	1.18505849924189	1.06370427864809	1.06961965983011	0.997963151715949	0.684383833902182	0.704108557016497	0.616660439455419	0.545577601391748	NA	0.679259357133661	0.684383833902182	0.705757910525191	0.696101742396156	NA	NA	p.Glu205Gly	1	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.254	-3.483	1.229	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205H	205	E	H	missense	wt-like	1.33870880242734	0.123200209278764	4	0.0616001046393818	1.21797481589026	1.45944278896443	NA	NA	NA	NA	1.51159135703843	1.34000532617221	1.2670406828963	1.23619784360244	0.741919223458428	NA	NA	NA	NA	0.727003270609209	0.737470030150193	0.746368416766663	0.749681076546086	NA	NA	p.Glu205His	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.254	-2.621	0.367	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205I	205	E	I	missense	possibly_wt-like	0.756596025912619	0.103121883838914	4	0.0515609419194571	0.655538436741521	0.857653615083716	NA	NA	NA	NA	0.821979460445927	0.722956003468511	0.854724105070702	0.626724534665335	0.622543567234865	NA	NA	NA	NA	0.626171853689029	0.618915280780702	0.661552804441349	0.612609628989809	NA	NA	p.Glu205Ile	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.254	-3.613	1.359	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205K	205	E	K	missense	low	0.537093536528809	0.158162391309506	4	0.0790811956547529	0.382097241191128	0.69208983186649	NA	NA	NA	NA	0.4874160073157	0.350103024499168	0.586120859409069	0.7247342548913	0.591776751346349	NA	NA	NA	NA	0.577253748889043	0.547278395612927	0.606299753803656	0.634652159858614	NA	NA	p.Glu205Lys	1	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.254	-2.335	0.081	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205L	205	E	L	missense	wt-like	1.11674608215413	0.153420416982565	4	0.0767102084912824	0.966396836264662	1.26709532804361	NA	NA	NA	NA	1.23237951616067	0.896585141900834	1.12833710124802	1.20968256930701	0.702007386501893	NA	NA	NA	NA	0.6861783868221	0.652274946260748	0.717836386181687	0.74371775218597	NA	NA	p.Glu205Leu	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.254	-3.154	0.9	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205M	205	E	M	missense	possibly_low	0.709940528589885	0.132951933889755	4	0.0664759669448773	0.579650027540451	0.84023102963932	NA	NA	NA	NA	0.603825498168574	0.757791024237804	0.601629712204007	0.876515879749156	0.617549098426899	NA	NA	NA	NA	0.594274531105316	0.625608193331823	0.609490003521974	0.66878807151649	NA	NA	p.Glu205Met	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.254	-3.565	1.311	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205N	205	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu205Asn	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.254	-3.056	0.802	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205P	205	E	P	missense	low	0.53521271037313	0.162871183908824	4	0.0814355919544119	0.375601883082783	0.694823537663477	NA	NA	NA	NA	0.695061733098874	0.322997208233045	0.623132544355963	0.499659355804638	0.595823547533297	NA	NA	NA	NA	0.607614612516238	0.542070508438195	0.613913245209986	0.584032482550356	NA	NA	p.Glu205Pro	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.254	-4.443	2.189	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205Q	205	E	Q	missense	possibly_wt-like	0.954730544582384	0.29989047669749	4	0.149945238348745	0.66084327776557	1.2486178113992	NA	NA	NA	NA	1.00300663041983	0.769090038585926	1.35775944908874	0.689066060235036	0.640209892401186	NA	NA	NA	NA	0.652640692378894	0.627779092423478	0.765029727317372	0.626630330187714	NA	NA	p.Glu205Gln	1	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.254	-2.274	0.02	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205R	205	E	R	missense	wt-like	0.961408326739607	0.128196781307772	4	0.064098390653886	0.835777789591011	1.0870388638882	NA	NA	NA	NA	0.8798042394287	0.874363391624195	1.14782581037313	0.943639865532403	0.665944899089989	NA	NA	NA	NA	0.634626688106386	0.648005443098416	0.721845312542573	0.683884355081561	NA	NA	p.Glu205Arg	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.254	-2.322	0.068	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205S	205	E	S	missense	wt-like	0.910964244799133	0.0218870966366487	4	0.0109435483183243	0.889515284232143	0.932413205366122	NA	NA	NA	NA	0.90608333518654	0.943198975123525	0.897044305590246	0.897530363296219	0.665744613389322	NA	NA	NA	NA	0.638469078984121	0.661230942340045	0.670258284438599	0.673514259910969	NA	NA	p.Glu205Ser	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.254	-2.862	0.608	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205T	205	E	T	missense	possibly_wt-like	0.831704123191161	0.121682887616188	4	0.0608414438080942	0.712457084559879	0.950951161822444	NA	NA	NA	NA	0.783665862036053	0.696468811738796	0.864056382806801	0.982625436182996	0.642021171294451	NA	NA	NA	NA	0.620569841261362	0.613826251003862	0.663472501327541	0.692652267514352	NA	NA	p.Glu205Thr	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.254	-3.081	0.827	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205V	205	E	V	missense	wt-like	1.01334105478487	0.0777298264876338	4	0.0388649132438169	0.937167224564711	1.08951488500502	NA	NA	NA	NA	1.06856750639085	1.04783496329904	1.0386988054326	0.898262944016971	0.677506926701607	NA	NA	NA	NA	0.662226658124773	0.681334835005906	0.699397333870289	0.673679018397309	NA	NA	p.Glu205Val	1	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.254	-3.221	0.967	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205W	205	E	W	missense	possibly_wt-like	0.763126416385993	0.116929668527889	4	0.0584648342639444	0.648537446866559	0.877715385905428	NA	NA	NA	NA	0.803177428653245	0.835041189643544	0.588877604217965	0.825409443029219	0.631936560193724	NA	NA	NA	NA	0.623422719696413	0.640450400691035	0.606866830199721	0.657294158398519	NA	NA	p.Glu205Trp	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.254	-5.848	3.594	0.00908292	NA	NA	NA	NA	NA	NA	NA
E205X	205	E	X	nonsense	low	0.230088009858418	0.201303292429264	4	0.100651646214632	0.0328144082930721	0.427361611423763	NA	NA	NA	NA	0.21981481368627	-0.000248939630493567	0.490859763207172	0.209926402170722	0.528498813001798	NA	NA	NA	NA	0.538126512748667	0.479964669189074	0.586704062920322	0.518871113254929	NA	NA	p.Glu205Ter	1	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E205Y	205	E	Y	missense	low	0.0917444957054729	0.317165038104675	3	0.183115320127272	-0.267154936761502	0.450643928172448	NA	NA	NA	NA	0.443028240374805	-0.173582712355041	0.00578795909665485	NA	0.486922331357784	NA	NA	NA	NA	0.570763603552676	0.446661752831293	0.486922331357784	NA	NA	NA	p.Glu205Tyr	0	39.8	19.2	7.8	0.921	110.7	51.2	-61.7	-43	47.196261682243	-5	1	0	18.17	1	4	0	0	8	22.4242830879443	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.254	-3.553	1.299	0.00908292	NA	NA	NA	NA	NA	NA	NA
R206A	206	R	A	missense	wt-like	1.2013465405742	0.124807768495751	4	0.0624038842478756	1.07903717495296	1.32365590619544	NA	NA	NA	NA	1.32750611541641	1.21078393633322	1.23730827223914	1.02978783830804	0.707950831667278	NA	NA	NA	NA	0.700087296800523	0.712642501909155	0.740252309019811	0.703259161425401	NA	NA	p.Arg206Ala	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.366	-2.312	-0.054	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206C	206	R	C	missense	possibly_low	0.597360858032048	0.284989935498181	4	0.14249496774909	0.318075853265635	0.876645862798462	NA	NA	NA	NA	0.178215959813007	0.748710428425833	0.799124135630177	0.663392908259177	0.622359961598276	NA	NA	NA	NA	0.532044147582083	0.623863522815216	0.650115608589958	0.620856400381336	NA	NA	p.Arg206Cys	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.366	-4.499	2.133	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206D	206	R	D	missense	possibly_low	0.631753448771385	0.161476395043826	4	0.0807381975219132	0.473509489451754	0.789997408091015	NA	NA	NA	NA	0.441823020185887	0.577863028749085	0.684664487975537	0.822663258175029	0.608804497922868	NA	NA	NA	NA	0.570587382608765	0.591038317594414	0.626570678251323	0.656676537367866	NA	NA	p.Arg206Asp	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.366	-2.823	0.457	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206E	206	R	E	missense	wt-like	0.848383801577092	0.111420932883573	4	0.0557104664417867	0.739193293789262	0.957574309364921	NA	NA	NA	NA	0.831525648447232	1.01022477916508	0.764552993278953	0.787231785417099	0.645856047990751	NA	NA	NA	NA	0.627567646985395	0.674108725536724	0.64300414917989	0.648707946801612	NA	NA	p.Arg206Glu	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.366	-2.571	0.205	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206F	206	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg206Phe	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.366	-4.151	1.785	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206G	206	R	G	missense	wt-like	0.865871791481033	0.0166472518194242	4	0.00832362590971211	0.849557784477213	0.882185798484853	NA	NA	NA	NA	0.859071553820284	0.883334303446145	0.845991283614403	0.875090025043299	0.654742729297435	NA	NA	NA	NA	0.631595264088345	0.649729039841067	0.659756418753804	0.668467394686724	NA	NA	p.Arg206Gly	1	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.366	-2.744	0.378	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206H	206	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg206His	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.366	-3.566	1.2	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206I	206	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg206Ile	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.366	-3.942	1.576	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206K	206	R	K	missense	wt-like	1.55305155008751	0.339506938779162	4	0.169753469389581	1.22034086383321	1.88576223634181	NA	NA	NA	NA	1.77185911407017	1.70294936318898	1.69078344085933	1.04661428223157	0.786130671765755	NA	NA	NA	NA	0.765058250301149	0.807203093230362	0.833534452327458	0.707043453521547	NA	NA	p.Arg206Lys	1	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.366	-2.659	0.293	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206L	206	R	L	missense	possibly_wt-like	1.00681228674396	0.412606395982535	4	0.206303197991267	0.602465448785642	1.41115912470228	NA	NA	NA	NA	1.12575468763394	0.408385064254986	1.35499092672872	1.13811846835821	0.699105573260932	NA	NA	NA	NA	0.670588266361093	0.558476224314396	0.764460228219275	0.727622880160772	NA	NA	p.Arg206Leu	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.366	-3.071	0.705	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206M	206	R	M	missense	wt-like	0.979241286046846	0.138388524211146	4	0.0691942621055729	0.843623024383099	1.11485954771059	NA	NA	NA	NA	1.16975622038574	0.838021791504146	0.954943468004677	0.954243664292822	0.679595187260883	NA	NA	NA	NA	0.677021938569978	0.641023068861231	0.682168435951788	0.686269165087795	NA	NA	p.Arg206Met	1	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.366	-3.763	1.397	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206N	206	R	N	missense	possibly_low	0.27547315804989	0.524933513485423	4	0.262466756742712	-0.23895223230486	0.789898548404641	NA	NA	NA	NA	-0.06647386258569	-0.17088657980455	0.985685888921219	0.353567185668583	0.523721514526569	NA	NA	NA	NA	0.49626689138868	0.44717976542288	0.68849230793421	0.551176137664458	NA	NA	p.Arg206Asn	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.366	-3.155	0.789	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206P	206	R	P	missense	possibly_low	0.572728214833057	0.181530899942076	4	0.0907654499710378	0.394831201849251	0.750625227816863	NA	NA	NA	NA	0.315257482435123	0.581819275206057	0.725556720014138	0.668279381676911	0.606876906756725	NA	NA	NA	NA	0.552081636742529	0.591798438041666	0.634982417885934	0.621955375471783	NA	NA	p.Arg206Pro	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.366	-4.445	2.079	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206Q	206	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg206Gln	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.366	-2.389	0.023	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206R	206	R	R	synonymous	possibly_wt-like	0.857218500615632	0.309528221079953	4	0.154764110539977	0.553886417857902	1.16055058337336	NA	NA	NA	NA	1.1629482532707	1.07024285821025	0.514115144673299	0.681567746308278	0.650485230904059	NA	NA	NA	NA	0.676026513499808	0.685640102457552	0.591487812895426	0.62494394830831	NA	NA	p.Arg206=	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206S	206	R	S	missense	low	0.337206177146098	0.11416919552485	4	0.0570845977624249	0.22532242145979	0.449089932832407	NA	NA	NA	NA	0.203067895953623	0.395219057779472	0.289107097863656	0.461430656987641	0.550574566345428	NA	NA	NA	NA	0.535677866702431	0.555946616809015	0.545202515881841	0.575434791711069	NA	NA	p.Arg206Ser	1	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.366	-2.372	0.006	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206T	206	R	T	missense	wt-like	1.03240285735701	0.0578369766952274	4	0.0289184883476137	0.975723661708342	1.08908205300567	NA	NA	NA	NA	1.10332569413884	1.02176708448386	1.04146974583253	0.963048904972785	0.682287922633206	NA	NA	NA	NA	0.667308817144252	0.676326368541691	0.699967330371464	0.688249476724721	NA	NA	p.Arg206Thr	1	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.366	-2.744	0.378	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206V	206	R	V	missense	possibly_wt-like	0.814378414812321	0.103418008968646	4	0.051709004484323	0.713030628346628	0.915726201278014	NA	NA	NA	NA	0.665863046034571	0.831473001340411	0.856624971192984	0.903552640681318	0.650854330386942	NA	NA	NA	NA	0.603345334385379	0.639764838525392	0.661943822248491	0.674868678991602	NA	NA	p.Arg206Val	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.366	-3.244	0.878	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206W	206	R	W	missense	possibly_wt-like	0.774602789481784	0.128358988218754	4	0.0641794941093771	0.648813292481404	0.900392286482163	NA	NA	NA	NA	0.926208194007522	0.665535997807243	0.835927547765413	0.670739418346957	0.631960135562974	NA	NA	NA	NA	0.641411629772854	0.607883076174855	0.657686257222066	0.622508641353095	NA	NA	p.Arg206Trp	1	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.366	-4.286	1.92	0.008086945	NA	NA	NA	NA	NA	NA	NA
R206X	206	R	X	nonsense	low	0.171501473437833	0.240708551300012	4	0.120354275650006	-0.0643885722215848	0.40739151909725	NA	NA	NA	NA	0.0461511253092248	-0.0405796218835408	0.172585560732138	0.507848829593508	0.516983883971794	NA	NA	NA	NA	0.512734323528664	0.472215865729636	0.521233444414924	0.585874307303802	NA	NA	p.Arg206Ter	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R206Y	206	R	Y	missense	wt-like	1.45152086582443	0.173419356639882	4	0.0867096783199408	1.28157301920629	1.62146871244257	NA	NA	NA	NA	1.53890979183959	1.47389976572813	1.59165066061104	1.20162324511897	0.752550298876841	NA	NA	NA	NA	0.730997628164021	0.763195399483662	0.813142336389239	0.74190519827002	NA	NA	p.Arg206Tyr	0	38.3	18.5	4.3	0.924	119.8	34.7	-56.7	-49.1	51.6981132075472	-2.9	1	0	20.01	1	3	0	0	6	22.1292792309418	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.366	-4.128	1.762	0.008086945	NA	NA	NA	NA	NA	NA	NA
L207A	207	L	A	missense	possibly_low	0.662913206612908	0.131950337752922	4	0.0659751688764611	0.533604251741096	0.792222161484719	NA	NA	NA	NA	0.758992549669689	0.467861031185661	0.707001807291345	0.717797438304936	0.624063908875662	NA	NA	NA	NA	0.616962239567847	0.569903444300764	0.631165578183476	0.633092059560565	NA	NA	p.Leu207Ala	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.499	-3.167	1.668	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207C	207	L	C	missense	wt-like	1.132357214806	0.196610474442057	4	0.0983052372210285	0.939682490361113	1.32503193925088	NA	NA	NA	NA	1.42702563477674	1.04275735581201	1.02338608063535	1.03625978799988	0.700481070574226	NA	NA	NA	NA	0.714638516403754	0.680359265532166	0.696247428676332	0.70471471247212	NA	NA	p.Leu207Cys	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.499	-3.483	1.984	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207D	207	L	D	missense	possibly_low	0.620044653617005	0.156485199479459	4	0.0782425997397297	0.466691976070352	0.773397331163658	NA	NA	NA	NA	0.674368595634694	0.437639115428698	0.804579298622946	0.563591604781683	0.601499955405981	NA	NA	NA	NA	0.604588971019409	0.564096855562714	0.651237763299346	0.598410939792553	NA	NA	p.Leu207Asp	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.499	-4.319	2.82	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207E	207	L	E	missense	low	0.289590438556957	0.215918836997583	4	0.107959418498792	0.0779938665074381	0.501187010606476	NA	NA	NA	NA	0.179244363094966	0.171146836970362	0.194837803725125	0.613132750437374	0.529002679502765	NA	NA	NA	NA	0.532194515289771	0.512895235013001	0.52581084371576	0.609552816637766	NA	NA	p.Leu207Glu	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.499	-4.144	2.645	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207F	207	L	F	missense	possibly_low	0.673349443024873	0.36731886805772	4	0.18365943402886	0.313383566907298	1.03331531914245	NA	NA	NA	NA	0.557672765209475	0.641766095809005	1.18261008657771	0.311348824503304	0.595421222847627	NA	NA	NA	NA	0.587526321740021	0.603316123955233	0.729000614667807	0.541681165869105	NA	NA	p.Leu207Phe	1	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.499	-3.2	1.701	0.006419928	NA	NA	NA	NA	8.12e-06	NA	NA
L207G	207	L	G	missense	low	0.204834799142628	0.254751712043211	4	0.127375856021605	-0.0448172911596778	0.454486889444934	NA	NA	NA	NA	-0.0632927785770391	0.0434862876827589	0.467242061757421	0.371903625707372	0.526016021422084	NA	NA	NA	NA	0.496732012726522	0.488367593755982	0.581845781886023	0.555300030117647	NA	NA	p.Leu207Gly	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.499	-2.955	1.456	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207H	207	L	H	missense	low	0.038227857044784	0.248970989207295	3	0.143743467639239	-0.243504162541023	0.319959876630591	NA	NA	NA	NA	-0.142086618148514	-0.0655261505035635	0.32229633978643	NA	0.485211192787321	NA	NA	NA	NA	0.485211192787321	0.467422846210181	0.552029711361436	NA	NA	NA	p.Leu207His	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.499	-2.447	0.948	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207I	207	L	I	missense	possibly_wt-like	0.880888264896682	0.166085343237194	4	0.0830426716185972	0.718127619344245	1.04364891044912	NA	NA	NA	NA	0.72519449140391	0.969646640475261	0.758801713465179	1.06991021424238	0.654066729791796	NA	NA	NA	NA	0.612020465620895	0.666312377845792	0.6418210817378	0.712282743045911	NA	NA	p.Leu207Ile	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.499	-2.757	1.258	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207K	207	L	K	missense	possibly_low	0.627774616056483	0.383395039536051	4	0.191697519768026	0.252054381385497	1.00349485072747	NA	NA	NA	NA	0.0841486810898191	0.778407095508686	0.673383902405132	0.975158785222293	0.626909699588871	NA	NA	NA	NA	0.518290125868781	0.629569194620657	0.624250204557086	0.69097300668279	NA	NA	p.Leu207Lys	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.499	-4.1	2.601	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207L	207	L	L	synonymous	wt-like	0.987015310547174	0.102026461955321	4	0.0510132309776603	0.887031215095937	1.08699940599841	NA	NA	NA	NA	0.953804023365946	0.887738165109957	1.12906408881054	0.977454964902253	0.671032291127043	NA	NA	NA	NA	0.645446546497821	0.650575161369122	0.717985931212335	0.691489420884964	NA	NA	p.Leu207=	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207M	207	L	M	missense	wt-like	1.19240073295245	0.0386252444583042	4	0.0193126222291521	1.15454868893628	1.23025277696862	NA	NA	NA	NA	1.16746856952275	1.20519711893523	1.15594374828536	1.24099349506646	0.717542155311464	NA	NA	NA	NA	0.676687450317855	0.711569097058	0.723515213564928	0.750759625644973	NA	NA	p.Leu207Met	1	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.499	-3.987	2.488	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207N	207	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu207Asn	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.499	-3.376	1.877	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207P	207	L	P	missense	low	0.388938077477419	0.147944920097509	4	0.0739724600487545	0.243954719934033	0.533921435020806	NA	NA	NA	NA	0.275443055916243	0.266142995839259	0.437130145869423	0.577036112284753	0.560955894563148	NA	NA	NA	NA	0.546260181138877	0.531147010667529	0.575651607987419	0.601434629391595	NA	NA	p.Leu207Pro	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.499	-4.535	3.036	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207Q	207	L	Q	missense	possibly_low	0.396600160879169	0.488813137983366	4	0.244406568991683	-0.0824279119295336	0.875628233687871	NA	NA	NA	NA	0.207034366126166	-0.202422066341415	0.865447837606428	0.716340506125496	0.58451110821343	NA	NA	NA	NA	0.536257823065779	0.441120798067983	0.663758730640647	0.63276439336108	NA	NA	p.Leu207Gln	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.499	-3.856	2.357	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207R	207	L	R	missense	low	0.573445708904539	0.111578675136684	4	0.0557893375683422	0.464100616549241	0.682790801259837	NA	NA	NA	NA	0.649408059541532	0.413691917623445	0.579652867122006	0.651029991331174	0.602954313977644	NA	NA	NA	NA	0.600939372986375	0.55949583919426	0.604969254968912	0.618075962100463	NA	NA	p.Leu207Arg	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.499	-3.122	1.623	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207S	207	L	S	missense	low	0.371229798797317	0.131006915991236	4	0.0655034579956179	0.242845380263074	0.499614217331561	NA	NA	NA	NA	0.245594164392734	0.344414785534377	0.339370714511899	0.555539530750259	0.5508637506732	NA	NA	NA	NA	0.541895833538896	0.546185504461423	0.555541996884977	0.596600016447538	NA	NA	p.Leu207Ser	1	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.499	-3.128	1.629	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207T	207	L	T	missense	wt-like	1.08449146159441	0.201470943565098	4	0.100735471782549	0.887053564934964	1.28192935825386	NA	NA	NA	NA	1.20047128256428	0.786993493595416	1.21612133530211	1.13437973491583	0.704147483282164	NA	NA	NA	NA	0.681512933077985	0.631218914076953	0.735894048580494	0.726782033486343	NA	NA	p.Leu207Thr	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.499	-3.542	2.043	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207V	207	L	V	missense	wt-like	0.90546621298618	0.0873351206101837	4	0.0436675603050919	0.819879367495469	0.991053058476891	NA	NA	NA	NA	0.907759123312332	0.831058334593537	0.855674422818323	1.02737297122053	0.650716728756654	NA	NA	NA	NA	0.638714103891632	0.639685167888964	0.661748289624344	0.70271605424993	NA	NA	p.Leu207Val	1	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.499	-2.748	1.249	0.006419928	NA	NA	NA	NA	NA	NA	NA
L207W	207	L	W	missense	wt-like	0.894155663063374	0.101714944547751	4	0.0508574722738756	0.794476849061833	0.993834477064914	NA	NA	NA	NA	0.994710825465023	0.781398794812713	0.964044826033391	0.836468205942369	0.655604507008133	NA	NA	NA	NA	0.651427723501443	0.630143994961776	0.684040631482388	0.659781290514822	NA	NA	p.Leu207Trp	1	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.499	-4.223	2.724	0.006419928	NA	NA	NA	NA	1.22e-05	NA	NA
L207X	207	L	X	nonsense	low	0.120365171458726	0.18128851709424	4	0.0906442585471201	-0.0572943106989662	0.298024653616419	NA	NA	NA	NA	-0.0461511253092252	-0.0231059134860629	0.241900966568513	0.30881675806168	0.517365175026526	NA	NA	NA	NA	0.499238374922256	0.475573119426215	0.535491975130797	0.541111700385756	NA	NA	p.Leu207Ter	1	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L207Y	207	L	Y	missense	possibly_wt-like	0.930675687063135	0.306440387626188	4	0.153220193813094	0.630369625485224	1.23098174864105	NA	NA	NA	NA	0.574511455183973	0.811389768579551	1.28589250737356	1.05090901711546	0.671957779079486	NA	NA	NA	NA	0.589988386239774	0.635906212417417	0.750246332723669	0.708009345741554	NA	NA	p.Leu207Tyr	0	34.8	19.4	5.4	0.824	137	13.8	-78.5	-36.4	7.32984293193717	-3	1	0	18.65	0	0	0	0	5	19.2045875014064	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.499	-2.36	0.861	0.006419928	NA	NA	NA	NA	NA	NA	NA
F208A	208	F	A	missense	low	0.54054616494999	0.141152154453704	4	0.0705760772268522	0.402219595415242	0.678872734484738	NA	NA	NA	NA	0.606302423278312	0.347581276779438	0.533011739400165	0.675289220342046	0.595005816180094	NA	NA	NA	NA	0.594636694040228	0.54679388787929	0.59537493831996	0.623531898543223	NA	NA	p.Phe208Ala	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.492	-3.689	2.197	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208C	208	F	C	missense	possibly_low	0.562996696079578	0.236263482779033	4	0.118131741389516	0.331462737525126	0.79453065463403	NA	NA	NA	NA	0.423289802347429	0.303135764704267	0.745628981268078	0.779932235998538	0.603494468528331	NA	NA	NA	NA	0.567877553175752	0.538254495077459	0.639111383880909	0.647066267353736	NA	NA	p.Phe208Cys	1	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.492	-4.089	2.597	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208D	208	F	D	missense	low	-0.156238568238855	0.226326840878819	4	0.11316342043941	-0.378034796667462	0.0655576601897514	NA	NA	NA	NA	-0.437830249616916	-0.241039053713353	0.0326544171116627	0.0212606132631855	0.459204508162036	NA	NA	NA	NA	0.441969117710852	0.433701249758255	0.492448898103104	0.476439898613219	NA	NA	p.Phe208Asp	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.492	-4.338	2.846	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208E	208	F	E	missense	low	0.241453604083696	0.340988496694793	4	0.170494248347396	-0.0927089822484287	0.57561619041582	NA	NA	NA	NA	-0.0179192573847049	-0.0320277289554459	0.687861738595855	0.327899664079078	0.524384881997203	NA	NA	NA	NA	0.503366289854117	0.473858955650362	0.627228368928108	0.54540347414029	NA	NA	p.Phe208Glu	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.492	-3.627	2.135	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208G	208	F	G	missense	low	0.152552765266882	0.272367085281038	4	0.136183542640519	-0.11436207359561	0.419467604129374	NA	NA	NA	NA	-0.122998959404272	-0.0399716958280493	0.388759786878586	0.384421929421263	0.523058752381808	NA	NA	NA	NA	0.488002089647396	0.472332667609959	0.565701579691593	0.55811541511622	NA	NA	p.Phe208Gly	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.492	-4.035	2.543	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208H	208	F	H	missense	low	-0.617738890042527	0.0519506392061925	2	0.0367346492696744	-0.689737479595799	-0.545740300489255	NA	NA	NA	NA	-0.581004240772853	-0.654473539312201	NA	NA	0.387651170567031	NA	NA	NA	NA	0.421034971322567	0.354267369811495	NA	NA	NA	NA	p.Phe208His	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.492	-3.651	2.159	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208I	208	F	I	missense	low	0.333286923535958	0.265578321691349	4	0.132789160845674	0.0730249507411401	0.593548896330776	NA	NA	NA	NA	0.13033724911224	0.0855023418475817	0.619601080927085	0.497707022256925	0.554318487349728	NA	NA	NA	NA	0.525043574848166	0.49644021062424	0.613186805262544	0.583593399851289	NA	NA	p.Phe208Ile	1	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.492	-3.822	2.33	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208K	208	F	K	missense	possibly_wt-like	0.729647310330328	0.626006308764152	4	0.313003154382076	0.116172400694029	1.34312221996663	NA	NA	NA	NA	0.0619091483466909	0.410543524511947	1.48860707779435	0.95752949066832	0.622949542647888	NA	NA	NA	NA	0.51503837860454	0.558890933001972	0.791945748517655	0.687008152293804	NA	NA	p.Phe208Lys	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.492	-4.183	2.691	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208L	208	F	L	missense	low	0.42267000185747	0.0692856950283253	4	0.0346428475141627	0.354771268407799	0.490568735307142	NA	NA	NA	NA	0.383668245378509	0.344847252738689	0.480975568792945	0.481188940519738	0.570981378403786	NA	NA	NA	NA	0.562084297941177	0.546268595130404	0.584670833972783	0.579878458866395	rs72556347	*26	p.Phe208Leu	1	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.492	-2.179	0.687	0.007200459	NA	NA	NA	NA	2.44e-05	NA	NA
F208M	208	F	M	missense	wt-like	1.02850705363679	0.236353216009327	4	0.118176608004663	0.796885158132545	1.26012894914104	NA	NA	NA	NA	1.35508852444102	1.03369188474858	0.916807613626049	0.808440191731524	0.676470599074199	NA	NA	NA	NA	0.704120251275012	0.678617500959552	0.674323697188846	0.653477748712953	NA	NA	p.Phe208Met	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.492	-2.976	1.484	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208N	208	F	N	missense	low	-0.133985209236509	0.460768653013073	4	0.230384326506536	-0.585530191791836	0.317559773318819	NA	NA	NA	NA	-0.62048885665242	-0.433590089673968	0.231764634849996	0.286373474530358	0.474334309576322	NA	NA	NA	NA	0.415261738892329	0.396706087509114	0.533406880260315	0.536064172764047	NA	NA	p.Phe208Asn	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.492	-3.74	2.248	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208P	208	F	P	missense	low	-0.0510098911375313	0.222514135347765	3	0.128468595941529	-0.302803712327357	0.200783930052294	NA	NA	NA	NA	-0.100304172416242	-0.244743371901438	0.192017870905086	NA	0.491320401787909	NA	NA	NA	NA	0.491320401787909	0.432989532723304	0.52523076922516	NA	NA	NA	p.Phe208Pro	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.492	-4.604	3.112	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208Q	208	F	Q	missense	low	0.274741329857734	0.182452123364165	4	0.0912260616820823	0.0959415345094233	0.453541125206045	NA	NA	NA	NA	0.144531765949621	0.142079847372415	0.530197292853591	0.28215641325531	0.53111738587067	NA	NA	NA	NA	0.527119022287926	0.507310544227488	0.594795992383652	0.535115749453414	NA	NA	p.Phe208Gln	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.492	-4.514	3.022	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208R	208	F	R	missense	low	-0.00981643761945804	0.275794461545654	4	0.137897230772827	-0.280090043502008	0.260457168263091	NA	NA	NA	NA	-0.279439945385941	-0.21293539343376	0.261845660341674	0.191263928000195	0.489901004221626	NA	NA	NA	NA	0.46512811319939	0.439100854422293	0.539594699847645	0.514673895243861	NA	NA	p.Phe208Arg	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.492	-4.454	2.962	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208S	208	F	S	missense	low	0.0587559092176131	0.213242179266368	4	0.106621089633184	-0.150217586455845	0.267729404891071	NA	NA	NA	NA	-0.109080470572316	-0.139817516329896	0.271013803267935	0.212907820504729	0.504789408184856	NA	NA	NA	NA	0.490037177727008	0.453149118111321	0.541480633370565	0.519541638642703	NA	NA	p.Phe208Ser	1	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.492	-3.202	1.71	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208T	208	F	T	missense	possibly_low	0.584060246735232	0.183687714014002	4	0.0918438570070009	0.404049594800264	0.764070898670201	NA	NA	NA	NA	0.474462517605724	0.437075124953913	0.580651518635513	0.844051825745778	0.590267220273917	NA	NA	NA	NA	0.575359757895019	0.563988495101201	0.605174682652815	0.661486857811908	NA	NA	p.Phe208Thr	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.492	-4.022	2.53	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208V	208	F	V	missense	possibly_wt-like	0.734306873750512	0.144377022664227	4	0.0721885113321135	0.592819991442008	0.875793756059016	NA	NA	NA	NA	0.923749787267714	0.740037817224383	0.698227244003934	0.575212646506016	0.625778922537061	NA	NA	NA	NA	0.641052174496392	0.622197239084668	0.629360605989455	0.601024529244147	NA	NA	p.Phe208Val	1	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.492	-2.934	1.442	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208W	208	F	W	missense	wt-like	1.10826182280085	0.192345292398658	4	0.0961726461993289	0.919766899952257	1.29675674564945	NA	NA	NA	NA	1.32088664826028	1.09786423263863	1.15752237330119	0.856774037003319	0.695033238955506	NA	NA	NA	NA	0.699119433200856	0.690947044710156	0.723839944741288	0.664348101918281	NA	NA	p.Phe208Trp	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.492	-3.492	2	0.007200459	NA	NA	NA	NA	NA	NA	NA
F208X	208	F	X	nonsense	low	-0.312894073817321	0.492599118791233	4	0.246299559395616	-0.795632339640813	0.169844192006171	NA	NA	NA	NA	-0.757136464763343	-0.626072686486114	0.335711075766466	-0.204078219786293	0.410521354001199	NA	NA	NA	NA	0.395281845835583	0.359724074591468	0.554789190624505	0.425760862166814	NA	NA	p.Phe208Ter	0	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F208Y	208	F	Y	missense	wt-like	0.898950200045184	0.104746385016859	4	0.0523731925084296	0.796300628973279	1.00159977111709	NA	NA	NA	NA	0.91957636256341	0.880458854705175	1.02466167054758	0.771103912364571	0.647128669623624	NA	NA	NA	NA	0.640441958332164	0.649176574920894	0.696509823994153	0.645080764326354	NA	NA	p.Phe208Tyr	1	35.4	22.3	7.9	0.556	96.9	91.4	-120.9	-15.1	0.43859649122807	-6.4	1	0	18.5	0	0	0	0	9	20.2359836836421	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.492	-1.611	0.119	0.007200459	NA	NA	NA	NA	NA	NA	NA
G209A	209	G	A	missense	wt-like	1.07022759044855	0.057398326848201	4	0.0286991634241005	1.01397826375088	1.12647691714621	NA	NA	NA	NA	1.1185251210733	0.99370202054722	1.05888106844838	1.10980215172529	0.687241553622693	NA	NA	NA	NA	0.669531197242028	0.670934179459515	0.70354892778587	0.721254498718269	NA	NA	p.Gly209Ala	1	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.691	-2.076	0.385	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209C	209	G	C	missense	possibly_low	0.698384826357047	0.126857553806512	4	0.0634287769032562	0.574066708043239	0.822702944670855	NA	NA	NA	NA	0.793493944028935	0.565044548292939	0.615710593599428	0.819290219506885	0.61719668194437	NA	NA	NA	NA	0.622006851611454	0.588575480861821	0.612386512277287	0.655917935988403	NA	NA	p.Gly209Cys	1	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.691	-4.357	2.666	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209D	209	G	D	missense	wt-like	1.18404205112623	0.096114775381645	4	0.0480573876908225	1.08985130206114	1.27823280019132	NA	NA	NA	NA	1.24703417492486	1.26830900976562	1.1642762429785	1.05654877683592	0.716486314700594	NA	NA	NA	NA	0.688321113789221	0.723694893366871	0.725229250005867	0.709277736034317	NA	NA	p.Gly209Asp	1	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.691	-2.588	0.897	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209E	209	G	E	missense	wt-like	0.846712394716404	0.070183834480916	4	0.035091917240458	0.777933500776646	0.915491288656161	NA	NA	NA	NA	0.915717161615925	0.761654669363846	0.818324669071896	0.891153078813947	0.646971471029995	NA	NA	NA	NA	0.639877686309542	0.626350522125839	0.654065255750448	0.672079999209729	NA	NA	p.Gly209Glu	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.691	-2.514	0.823	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209F	209	G	F	missense	possibly_low	0.699911958325372	0.174790197829987	4	0.0873950989149934	0.528620712026669	0.871203204624074	NA	NA	NA	NA	0.886367105528658	0.486823035795323	0.787820232738977	0.638637459238529	0.625437569561623	NA	NA	NA	NA	0.635586275797936	0.573546646912496	0.647790338404512	0.615288863325311	NA	NA	p.Gly209Phe	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.691	-4.767	3.076	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209G	209	G	G	synonymous	wt-like	1.10247607421237	0.0670320999412848	4	0.0335160499706424	1.03678582336587	1.16816632505888	NA	NA	NA	NA	1.1667084372032	1.1526393538015	1.0574144523368	1.03314205350798	0.702359160255224	NA	NA	NA	NA	0.676576307776368	0.701471083100952	0.703247237409496	0.704013529379058	NA	NA	p.Gly209=	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209H	209	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209His	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.691	-3.592	1.901	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209I	209	G	I	missense	possibly_low	0.554103302860498	0.456170241856041	4	0.22808512092802	0.107064680432115	1.00114192528888	NA	NA	NA	NA	0.207853594085518	0.116527322506738	0.892532908056768	0.999499386792967	0.60285393666675	NA	NA	NA	NA	0.536377606260255	0.502401093605398	0.669330267073246	0.696447243934461	NA	NA	p.Gly209Ile	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.691	-3.909	2.218	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209K	209	G	K	missense	wt-like	0.860638660973824	0.0862793621756817	4	0.0431396810878409	0.776086439737113	0.945190882210536	NA	NA	NA	NA	0.817762719073038	0.980640338838232	0.861569123784755	0.782582462199273	0.655311583333391	NA	NA	NA	NA	0.625555303989821	0.668424616051248	0.662960859525315	0.647662307141467	NA	NA	p.Gly209Lys	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.691	-3.314	1.623	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209L	209	G	L	missense	possibly_wt-like	0.768961291299952	0.0654176904999176	4	0.0327088452499588	0.704853132634139	0.833069449965765	NA	NA	NA	NA	0.702828209576245	0.722878034942941	0.829808574717782	0.820330345962841	0.637526081259248	NA	NA	NA	NA	0.608750185773545	0.618900300553567	0.656427553415942	0.656151861964929	NA	NA	p.Gly209Leu	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.691	-4.01	2.319	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209M	209	G	M	missense	wt-like	1.41792959836312	0.323430467552463	2	0.228699876848682	0.969686076470956	1.86617312025528	NA	NA	NA	NA	1.6466294752118	1.18922972151444	NA	NA	0.727624543007208	NA	NA	NA	NA	0.746747832530103	0.708501253484312	NA	NA	NA	NA	p.Gly209Met	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.691	-4.286	2.595	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209N	209	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209Asn	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.691	-3.26	1.569	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209P	209	G	P	missense	possibly_wt-like	0.739563968950766	0.323240686470272	4	0.161620343235136	0.422793917040897	1.05633402086063	NA	NA	NA	NA	0.661494887346855	0.332495631650513	1.0916202435049	0.872645113300797	0.635312087834202	NA	NA	NA	NA	0.602706645244442	0.543895456892444	0.710283542227249	0.667917530423962	NA	NA	p.Gly209Pro	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.691	-3.831	2.14	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209Q	209	G	Q	missense	possibly_wt-like	1.48521299309609	0.552254050178705	2	0.390502583819098	0.719841992940826	2.25058399325136	NA	NA	NA	NA	1.87571557691519	1.09471040927699	NA	NA	0.735292345058702	NA	NA	NA	NA	0.780243594922849	0.690341095194555	NA	NA	NA	NA	p.Gly209Gln	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.691	-2.788	1.097	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209R	209	G	R	missense	wt-like	0.837598958871548	0.0598660308857033	4	0.0299330154428517	0.778931326654877	0.896266591088218	NA	NA	NA	NA	0.872917541481411	0.819271546791893	0.89627546123562	0.761931285977268	0.640219189572249	NA	NA	NA	NA	0.633619751428876	0.63742055204339	0.670100129253415	0.643017827101108	NA	NA	p.Gly209Arg	1	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.691	-3.079	1.388	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209S	209	G	S	missense	possibly_low	0.687821854992884	0.133554814150452	4	0.0667774070752262	0.55694054214447	0.818703167841297	NA	NA	NA	NA	0.574161380482288	0.857376456657742	0.731572497137118	0.588177085694388	0.620080072268352	NA	NA	NA	NA	0.589937200161963	0.64474171401971	0.636219893766697	0.603940250770007	NA	NA	p.Gly209Ser	1	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.691	-2.264	0.573	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209T	209	G	T	missense	wt-like	1.20899051479188	0.040406630368129	4	0.0202033151840645	1.1693927446628	1.24858828492096	NA	NA	NA	NA	1.23165774551176	1.21610430903578	1.14999658298609	1.2382034216339	0.717978282883218	NA	NA	NA	NA	0.68607285332191	0.713664714281969	0.722291851484467	0.750132134008208	NA	NA	p.Gly209Thr	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.691	-2.894	1.203	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209V	209	G	V	missense	possibly_wt-like	0.786291807282308	0.170599247133884	4	0.0852996235669418	0.619107617196278	0.953475997368337	NA	NA	NA	NA	0.840463692597909	0.56949920242741	0.757702363872455	0.977501970231456	0.635234730320581	NA	NA	NA	NA	0.628874520693144	0.589431361234764	0.641594939948018	0.691499992452943	NA	NA	p.Gly209Val	1	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.691	-3.511	1.82	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209W	209	G	W	missense	possibly_wt-like	0.77934629963518	0.170202382294509	4	0.0851011911472545	0.612551029945103	0.946141569325258	NA	NA	NA	NA	0.971940686806208	0.705593569614273	0.856513940419296	0.583337001700945	0.63183890014529	NA	NA	NA	NA	0.648098393836769	0.61557940645381	0.661920982654927	0.602851708729615	NA	NA	p.Gly209Trp	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.691	-4.451	2.76	0.008642251	NA	NA	NA	NA	NA	NA	NA
G209X	209	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209Ter	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G209Y	209	G	Y	missense	wt-like	0.991231726637863	0.122710201415165	4	0.0613551007075826	0.870977938983173	1.11148551429255	NA	NA	NA	NA	1.15915402226524	0.906635084226887	0.893233701991035	1.00590409806829	0.672473082490665	NA	NA	NA	NA	0.675471741039684	0.654205858993012	0.669474423941646	0.697887672961976	NA	NA	p.Gly209Tyr	0	39	23.5	7.6	0.741	82.2	57.3	-62.8	-31.7	18.5567010309278	-2.6	0	0	21.14	0	0	0	0	6	23.7990312867999	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.691	-4.748	3.057	0.008642251	NA	NA	NA	NA	NA	NA	NA
K210A	210	K	A	missense	wt-like	0.850919882356192	0.0445220981667893	4	0.0222610490833947	0.80728902789466	0.894550736817724	NA	NA	NA	NA	0.909006202283428	0.845564294547625	0.800536983771952	0.848572048821763	0.64643923079332	NA	NA	NA	NA	0.638896445206056	0.642472222964537	0.650406238622102	0.662503462659433	NA	NA	p.Lys210Ala	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.603	-2.322	-0.281	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210C	210	K	C	missense	wt-like	0.981005197050859	0.177400393509197	4	0.0887001967545986	0.807156005990229	1.15485438811149	NA	NA	NA	NA	0.749645253421434	0.937641171751643	1.14354859423706	1.0931857687933	0.688840280826576	NA	NA	NA	NA	0.615595527175353	0.66016311200371	0.720965467479003	0.717517449649443	NA	NA	p.Lys210Cys	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.603	-5.587	2.984	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210D	210	K	D	missense	wt-like	0.984561324457753	0.0978796402784393	4	0.0489398201392196	0.888641039575014	1.08048160934049	NA	NA	NA	NA	1.10662726255123	0.983814128972399	0.866974359908555	0.980829546398826	0.668412978446924	NA	NA	NA	NA	0.667791555076595	0.669034401817253	0.664072744024407	0.69224836924882	NA	NA	p.Lys210Asp	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.603	-2.385	-0.218	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210E	210	K	E	missense	possibly_low	0.644854969516131	0.307472316845638	4	0.153736158422819	0.343537635885862	0.946172303146401	NA	NA	NA	NA	0.249282835525338	0.589807746285377	0.976422034581793	0.763907261672016	0.618397751852971	NA	NA	NA	NA	0.542435171590764	0.593333276751973	0.686586686087922	0.64346222695397	NA	NA	p.Lys210Glu	1	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.603	-2.479	-0.124	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210F	210	K	F	missense	wt-like	1.17224343442722	0.0536110126598747	4	0.0268055063299374	1.11970560743318	1.22478126142126	NA	NA	NA	NA	1.22076347736905	1.09605170160624	1.179747371774	1.19241118695959	0.709505269853254	NA	NA	NA	NA	0.684479950852323	0.690598800000434	0.728411739706073	0.73983339278098	NA	NA	p.Lys210Phe	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.603	-4.848	2.245	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210G	210	K	G	missense	possibly_wt-like	0.756322174265404	0.087368308469525	4	0.0436841542347625	0.670702805270177	0.841941543260631	NA	NA	NA	NA	0.634864781110702	0.763459294077274	0.785533565931511	0.841431055942129	0.637008603609796	NA	NA	NA	NA	0.59881293146457	0.626697247780879	0.647319959438713	0.660897442811398	NA	NA	p.Lys210Gly	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.603	-2.378	-0.225	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210H	210	K	H	missense	wt-like	1.5053594312899	0.243965565935892	4	0.121982782967946	1.26627756993876	1.74444129264104	NA	NA	NA	NA	1.56570678128791	1.20906670603102	1.79551124126194	1.45115299657872	0.766470275365907	NA	NA	NA	NA	0.734915742727619	0.712312567492901	0.855077492302891	0.798024808004196	NA	NA	p.Lys210His	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.603	-3.333	0.73	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210I	210	K	I	missense	wt-like	1.55735119283924	0.256993419573407	4	0.128496709786704	1.30550226952541	1.80920011615308	NA	NA	NA	NA	1.71584822120398	1.80189380822666	1.22935216881277	1.48231057311356	0.780950412873855	NA	NA	NA	NA	0.756868632751671	0.82621345990826	0.738615698172414	0.80503219299604	NA	NA	p.Lys210Ile	1	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.603	-4.487	1.884	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210K	210	K	K	synonymous	wt-like	1.35855948273493	0.309826841110795	4	0.154913420555398	1.05493475772444	1.66218420774542	NA	NA	NA	NA	1.65045850337392	1.6016233086932	1.10840331641696	1.07375280245564	0.73052179916833	NA	NA	NA	NA	0.747307692847075	0.787735143824452	0.713735905489584	0.713146946811739	NA	NA	p.Lys210=	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210L	210	K	L	missense	wt-like	1.16288387995645	0.138228966849387	4	0.0691144834246934	1.02742198163396	1.29834577827894	NA	NA	NA	NA	1.19435034761985	1.34136951717993	1.02301844966495	1.09279720536108	0.706800933139859	NA	NA	NA	NA	0.680617962230799	0.737732134518613	0.696171805120207	0.717430061159512	NA	NA	p.Lys210Leu	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.603	-3.465	0.862	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210M	210	K	M	missense	wt-like	1.19292448673263	0.196410153837376	4	0.0982050769186882	1.00044607287302	1.38540290059225	NA	NA	NA	NA	1.43952247064769	1.26036777296554	1.0128742686801	1.05893343463721	0.713139893488458	NA	NA	NA	NA	0.716465737880228	0.722169129860005	0.694085095615809	0.709814049096687	NA	NA	p.Lys210Met	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.603	-4.161	1.558	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210N	210	K	N	missense	possibly_wt-like	0.806961766143217	0.107829754173119	4	0.0539148770865594	0.701290548822657	0.912632983463777	NA	NA	NA	NA	0.826870599699813	0.854479541183326	0.895629614975835	0.650867308713893	0.635536067475521	NA	NA	NA	NA	0.626887010291982	0.644185124659059	0.669967275400483	0.618039374539505	NA	NA	p.Lys210Asn	1	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.603	-2.865	0.262	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210P	210	K	P	missense	wt-like	1.11356427648673	0.277683550445279	4	0.13884177522264	0.841439397500746	1.3856891554727	NA	NA	NA	NA	1.30666662159289	1.39155374154229	0.824194318253098	0.931842424558625	0.689135674513187	NA	NA	NA	NA	0.697040255848203	0.747374115998332	0.655272672372074	0.681231093178171	NA	NA	p.Lys210Pro	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.603	-2.551	-0.052	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210Q	210	K	Q	missense	possibly_wt-like	0.908555058254867	0.335611903944074	4	0.167805951972037	0.579661435998217	1.23744868051152	NA	NA	NA	NA	1.1779259342282	1.11401297982064	0.906088771165217	0.436192547805404	0.675167623986156	NA	NA	NA	NA	0.678216471069545	0.694049731325882	0.672118776902768	0.569758703671667	NA	NA	p.Lys210Gln	1	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.603	-2.937	0.334	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210R	210	K	R	missense	wt-like	1.26174220953527	0.142675622328207	4	0.0713378111641034	1.1219226689177	1.40156175015283	NA	NA	NA	NA	1.45692644979939	1.15218161698724	1.27935754848153	1.1585032228729	0.725608948774844	NA	NA	NA	NA	0.719010455984117	0.701383137338279	0.748902058518467	0.732207441565571	NA	NA	p.Lys210Arg	1	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.603	-3.144	0.541	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210S	210	K	S	missense	wt-like	1.17800741204843	0.116887145738393	4	0.0584435728691963	1.06346011409696	1.2925547099999	NA	NA	NA	NA	1.19509304612487	1.06310717321404	1.12035491363783	1.33347451521699	0.700231760345906	NA	NA	NA	NA	0.68072655569181	0.684269111006497	0.716194409685314	0.771558743699252	NA	NA	p.Lys210Ser	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.603	-2.477	-0.126	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210T	210	K	T	missense	possibly_wt-like	0.940749041271581	0.3977258688305	8	0.140617329451679	0.665144139944087	1.21635394259907	0.970233877927984	1.1155257821644	0.460783584559824	0.311993456940428	1.56881695475021	1.17482607250649	0.96563176720862	0.958180834114695	0.68576085686603	0.679939036355487	0.698517417473919	0.556394576045142	0.496465802233443	0.735370495899107	0.705733855587073	0.684367073334936	0.687154640397125	NA	NA	p.Lys210Thr	1	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.603	-2.754	0.151	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210V	210	K	V	missense	possibly_low	0.681351097992793	0.153485088343797	4	0.0767425441718987	0.530938475333897	0.831763720651688	NA	NA	NA	NA	0.572527231771388	0.559986292539498	0.70261698695517	0.890273880705113	0.609980930970075	NA	NA	NA	NA	0.589698263550236	0.587603629469993	0.630263598389914	0.671882266256211	NA	NA	p.Lys210Val	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.603	-3.396	0.793	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210W	210	K	W	missense	wt-like	0.906538042478715	0.0999391407615304	4	0.0499695703807652	0.808599484209476	1.00447660074795	NA	NA	NA	NA	0.878111409535729	1.03646870233394	0.796112282710385	0.915459775334802	0.663521333163282	NA	NA	NA	NA	0.634379171441496	0.679151015705885	0.649496055160956	0.677546611165608	NA	NA	p.Lys210Trp	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.603	-4.308	1.705	0.010803404	NA	NA	NA	NA	NA	NA	NA
K210X	210	K	X	nonsense	low	0.297109897455846	0.284271690421203	4	0.142135845210602	0.0185287599309072	0.575691034980786	NA	NA	NA	NA	0.232068713201773	-0.0708248412817804	0.446178353760579	0.581017364142814	0.558715541808332	NA	NA	NA	NA	0.539918213351646	0.466404799622842	0.577512870265018	0.602330018815985	NA	NA	p.Lys210Ter	1	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K210Y	210	K	Y	missense	wt-like	1.27121319543188	0.0266817099705906	4	0.0133408549852953	1.24506560013773	1.29736079072603	NA	NA	NA	NA	1.3012754573262	1.24141382879643	1.25796754668631	1.28419594891859	0.731514751260994	NA	NA	NA	NA	0.69625198822326	0.718527475914603	0.744502026607385	0.7604759213394	NA	NA	p.Lys210Tyr	0	38.4	26.2	5	0.854	122.7	24.6	-68.4	-33	83.9130434782609	-0.9	0	0	23.92	0	0	0	0	5	25.7015252325809	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.603	-4.797	2.194	0.010803404	NA	NA	NA	NA	NA	NA	NA
I211A	211	I	A	missense	wt-like	1.35185071685471	0.141425408215527	4	0.0707127041077636	1.21325636355406	1.49044507015537	NA	NA	NA	NA	1.43421223203239	1.33868953767957	1.15810838097247	1.47639271673441	0.730588857466647	NA	NA	NA	NA	0.715689302777513	0.737217225440376	0.723960489492918	0.803701258353907	NA	NA	p.Ile211Ala	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-3.097	-2.605	-0.492	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211C	211	I	C	missense	wt-like	1.19554128537552	0.0689140472073344	4	0.0344570236036672	1.12800676009789	1.26307581065316	NA	NA	NA	NA	1.25468548536531	1.25523935421143	1.14398778918828	1.12825251273708	0.721119805019558	NA	NA	NA	NA	0.68943984807559	0.721183797929988	0.721055812109127	0.725404012166581	NA	NA	p.Ile211Cys	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-3.097	-3.906	0.809	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211D	211	I	D	missense	wt-like	1.31026536489104	0.107440908388912	4	0.0537204541944558	1.20497520943677	1.4155555203453	NA	NA	NA	NA	1.3114711424141	1.43826412024032	1.31601437939032	1.1753118175194	0.746168190429536	NA	NA	NA	NA	0.697742747560452	0.756348661526127	0.756442554648482	0.735987719332945	NA	NA	p.Ile211Asp	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-3.097	-2.8	-0.297	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211E	211	I	E	missense	possibly_low	0.540624582563204	0.216421667974144	4	0.108210833987072	0.3285352452115	0.752713919914908	NA	NA	NA	NA	0.356897373696127	0.431630725980283	0.525682827678671	0.848287402897735	0.578404898668076	NA	NA	NA	NA	0.558170002179661	0.562942453347264	0.593867343988888	0.662439445370611	NA	NA	p.Ile211Glu	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-3.097	-3.112	0.015	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211F	211	I	F	missense	wt-like	1.30686608476448	0.109986898164289	4	0.0549934490821447	1.19908090517784	1.41465126435112	NA	NA	NA	NA	1.40358758990066	1.3475112195858	1.32720377319482	1.14916175637663	0.734509341166314	NA	NA	NA	NA	0.711211529012191	0.738912150382239	0.758744269733727	0.730106531950389	NA	NA	p.Ile211Phe	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-3.097	-3.046	-0.051	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211G	211	I	G	missense	wt-like	1.07385184659604	0.0257380797643059	4	0.0128690398821529	1.04862899191141	1.09907470128067	NA	NA	NA	NA	1.03893093078124	1.09489764893894	1.09148264197451	1.07009616468946	0.700316153383782	NA	NA	NA	NA	0.657893354238711	0.690377069873364	0.7102552368942	0.712324563576166	NA	NA	p.Ile211Gly	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-3.097	-2.852	-0.245	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211H	211	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile211His	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-3.097	-2.757	-0.34	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211I	211	I	I	synonymous	wt-like	1.35215656039732	0.137200233466606	4	0.0686001167333028	1.21770280226481	1.48661031852984	NA	NA	NA	NA	1.53453293606016	1.33955499511767	1.33299596564919	1.20154234476227	0.739635255464588	NA	NA	NA	NA	0.730357667380172	0.737383507268893	0.759935753113595	0.741887003660284	NA	NA	p.Ile211=	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211K	211	I	K	missense	wt-like	1.03465310750895	0.176777847935686	4	0.088388923967843	0.861413999899726	1.20789221511817	NA	NA	NA	NA	1.22721478245695	0.820067304958714	1.11771246879266	0.973617873827469	0.688024840057187	NA	NA	NA	NA	0.685423226680672	0.637573442430844	0.715650845371794	0.690626453433702	NA	NA	p.Ile211Lys	1	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-3.097	-3.017	-0.08	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211L	211	I	L	missense	possibly_wt-like	0.865280277122479	0.21943534075726	4	0.10971767037863	0.650237594712728	1.08032295953223	NA	NA	NA	NA	0.800192613887196	0.589271160211067	0.981677660358949	1.08997967403271	0.655327045396156	NA	NA	NA	NA	0.622986295812788	0.593230181545132	0.687667794979524	0.716796394201415	NA	NA	p.Ile211Leu	1	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-3.097	-2.943	-0.154	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211M	211	I	M	missense	wt-like	1.59572769402976	0.4003768595882	3	0.231157687660544	1.14266695146554	2.04878843659399	NA	NA	NA	NA	1.92292502605161	1.71498598680198	NA	1.1492720692357	0.78714631175817	NA	NA	NA	NA	0.78714631175817	0.809515710460768	NA	0.73013134147536	NA	NA	p.Ile211Met	1	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-3.097	-3.517	0.42	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211N	211	I	N	missense	possibly_wt-like	1.29873029579848	0.628545928716226	4	0.314272964358113	0.682766604341937	1.91469398725502	NA	NA	NA	NA	0.449877080562824	1.26206277176717	1.93022351279402	1.5527578180699	0.771685337679179	NA	NA	NA	NA	0.571765004868155	0.722494792899758	0.882788490143391	0.820875882458599	NA	NA	p.Ile211Asn	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-3.097	-3.076	-0.021	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211P	211	I	P	missense	possibly_wt-like	0.863767417725829	0.147263544024945	4	0.0736317720124727	0.719451796463518	1.00808303898814	NA	NA	NA	NA	0.791209272593989	0.816059764517871	0.76533326724224	1.08246736654921	0.63998406113784	NA	NA	NA	NA	0.621672798995597	0.636803466782105	0.643164655493574	0.715106865150429	NA	NA	p.Ile211Pro	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-3.097	-4.068	0.971	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211Q	211	I	Q	missense	wt-like	1.27781880490913	0.197186259870769	4	0.0985931299353844	1.0845798211127	1.47105778870556	NA	NA	NA	NA	1.2995960943107	1.00405514922037	1.33497192218116	1.47265205392429	0.728174329006632	NA	NA	NA	NA	0.696006440614215	0.672923343906949	0.760342217399049	0.802859977761822	NA	NA	p.Ile211Gln	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-3.097	-3.037	-0.06	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211R	211	I	R	missense	wt-like	0.99540802959793	0.11398237722211	4	0.0569911886110552	0.883707352484133	1.10710870671173	NA	NA	NA	NA	1.05570994928357	0.827552956013018	1.07545682808287	1.02291238501226	0.68102977785618	NA	NA	NA	NA	0.660346693890303	0.63901167346353	0.706958645655014	0.701712861822056	NA	NA	p.Ile211Arg	1	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-3.097	-2.668	-0.429	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211S	211	I	S	missense	wt-like	1.20278050372506	0.218490224409462	4	0.109245112204731	0.988664018316752	1.41689698913337	NA	NA	NA	NA	1.41521122233158	1.35578886680461	0.957201182832521	1.08292074293153	0.714059952726235	NA	NA	NA	NA	0.712911075283885	0.740502549002394	0.682632859348464	0.715208830168585	NA	NA	p.Ile211Ser	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-3.097	-2.759	-0.338	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211T	211	I	T	missense	possibly_low	0.266349097210654	1.39488391462539	2	0.986331874999649	-1.66682585459252	2.19952404901383	NA	NA	NA	NA	-0.719982777788995	1.2526809722103	NA	NA	0.560703256857609	NA	NA	NA	NA	0.400714262126461	0.720692251588756	NA	NA	NA	NA	p.Ile211Thr	1	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-3.097	-2.843	-0.254	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211V	211	I	V	missense	wt-like	1.08393091194072	0.081443018459007	4	0.0407215092295035	1.00411822045478	1.16374360342666	NA	NA	NA	NA	1.19061698159545	1.10445729229432	1.02176383595375	1.01888553791936	0.694063752666563	NA	NA	NA	NA	0.680072089127417	0.692213780619748	0.695913724713378	0.700807217961993	NA	NA	p.Ile211Val	1	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-3.097	-2.901	-0.196	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211W	211	I	W	missense	wt-like	1.24878049376152	0.114941815587548	4	0.0574709077937739	1.1361395843269	1.36142140319614	NA	NA	NA	NA	1.35305712850199	1.30431483680092	1.24920995614621	1.08854005359697	0.723542688190753	NA	NA	NA	NA	0.70382323126728	0.730612754942843	0.742700545793612	0.716472621438663	NA	NA	p.Ile211Trp	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-3.097	-3.748	0.651	0.011714464	NA	NA	NA	NA	NA	NA	NA
I211X	211	I	X	nonsense	low	0.160282526791096	0.359299245363532	4	0.179649622681766	-0.191824263501376	0.512389317083567	NA	NA	NA	NA	-0.0543378039317895	-0.195325849242676	0.606933641754441	0.283860118584407	0.516770138610386	NA	NA	NA	NA	0.498041361921955	0.442484206483904	0.610581048744853	0.535498915298816	NA	NA	p.Ile211Ter	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I211Y	211	I	Y	missense	low	0.265661731982057	0.00428056544359587	3	0.00247138561114388	0.260817905192304	0.270505558771809	NA	NA	NA	NA	0.269950344399922	0.26138925915279	NA	0.265645592393457	0.53140244145011	NA	NA	NA	NA	0.545457065810298	0.530233667048637	NA	0.53140244145011	NA	NA	p.Ile211Tyr	0	35.9	28.1	7.1	0.728	117.3	63.4	-101.9	-26.4	41.8848167539267	-2.7	0	0	22.12	0	0	0	0	5	24.5829160783939	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-3.097	-3.034	-0.063	0.011714464	NA	NA	NA	NA	NA	NA	NA
C212A	212	C	A	missense	wt-like	1.24779512814212	0.0501152934609713	4	0.0250576467304857	1.19868304301304	1.2969072132712	NA	NA	NA	NA	1.18993177452924	1.22859294032571	1.30692143388449	1.26573436382904	0.735318133071275	NA	NA	NA	NA	0.679971901761579	0.716064176526022	0.754572089616528	0.756323883579419	NA	NA	p.Cys212Ala	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.246	-2.761	0.515	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212C	212	C	C	synonymous	wt-like	1.31395663294134	0.141493616198478	4	0.0707468080992391	1.17529543704567	1.45261782883702	NA	NA	NA	NA	1.39587651906679	1.41776949236542	1.33361809309131	1.10856242724185	0.736693338108335	NA	NA	NA	NA	0.710084056876063	0.752410993366176	0.760063727885373	0.720975682850495	NA	NA	p.Cys212=	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	0	2.5	2.5	0	148	148	0	5.5	5.5	0	121	121	0	5.07	5.07	0	NA	NA	NA	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212D	212	C	D	missense	low	0.237411156820785	0.379842844827622	4	0.189921422413811	-0.134827991002903	0.609650304644473	NA	NA	NA	NA	-0.0231081743824669	-0.104484804726744	0.356099629714157	0.721137976678195	0.530795406695239	NA	NA	NA	NA	0.502607593758891	0.45993765285973	0.558983219631586	0.633843351575696	NA	NA	p.Cys212Asp	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.246	-3.617	1.371	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212E	212	C	E	missense	low	0.308259811358286	0.0732470933299127	4	0.0366235466649564	0.23647897890885	0.380040643807723	NA	NA	NA	NA	0.234773650250126	0.307824212163454	0.408318992198562	0.282122390821003	0.539734504777562	NA	NA	NA	NA	0.540313714990485	0.539155294564639	0.569725007477492	0.535108097757677	NA	NA	p.Cys212Glu	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.246	-3.57	1.324	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212F	212	C	F	missense	possibly_low	0.496129487223777	0.376729716933348	3	0.2175050034832	0.0698275139394458	0.922431460508108	NA	NA	NA	NA	0.493514069675204	0.120714288128147	0.87416010386798	NA	0.578145375427411	NA	NA	NA	NA	0.578145375427411	0.503205542523177	0.665550888020328	NA	NA	NA	p.Cys212Phe	1	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.246	-2.24	-0.006	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212G	212	C	G	missense	wt-like	0.942268103975236	0.0415399875211008	4	0.0207699937605504	0.901559664245436	0.982976543705037	NA	NA	NA	NA	0.919484640483338	0.921430219706351	1.00452625657826	0.923631299132995	0.668216436400037	NA	NA	NA	NA	0.640428547213037	0.657048473860442	0.692367867165161	0.679384398939633	NA	NA	p.Cys212Gly	1	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.246	-3.035	0.789	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212H	212	C	H	missense	low	-0.173682128852482	0.499952165201769	4	0.249976082600884	-0.663626247746625	0.31626199004166	NA	NA	NA	NA	-0.666435129320578	-0.520356751385734	0.114600480184548	0.377462885111835	0.458924668084192	NA	NA	NA	NA	0.408543717062626	0.380035459320441	0.509305619105759	0.556550315770417	NA	NA	p.Cys212His	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.246	-3.373	1.127	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212I	212	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys212Ile	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.246	-3.526	1.28	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212K	212	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys212Lys	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.246	-4.247	2.001	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212L	212	C	L	missense	possibly_wt-like	0.840289514221144	0.197696930707707	4	0.0988484653538537	0.646550082200536	1.03402894624175	NA	NA	NA	NA	1.02688578623007	0.650584034464078	0.994226954841758	0.689461281348673	0.641425696343203	NA	NA	NA	NA	0.656132176686374	0.605010329699803	0.690249248535002	0.626719216000032	NA	NA	p.Cys212Leu	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.246	-2.779	0.533	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212M	212	C	M	missense	possibly_wt-like	0.728739277926879	0.204155069629872	4	0.102077534814936	0.528670986058971	0.928807569794787	NA	NA	NA	NA	0.831136746062622	0.830751041379504	0.830562440908203	0.422506883357186	0.6335684554214	NA	NA	NA	NA	0.627510783728427	0.639626127114374	0.656582627516744	0.566680777519399	NA	NA	p.Cys212Met	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.246	-3.922	1.676	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212N	212	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys212Asn	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.246	-4.437	2.191	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212P	212	C	P	missense	low	0.51820179741131	0.167382181619938	4	0.0836910908099689	0.3541702735969	0.68223332122572	NA	NA	NA	NA	0.500060745266324	0.316959398910789	0.530020558551365	0.725766486916761	0.586931116534475	NA	NA	NA	NA	0.57910259582809	0.540910453731702	0.59475963724086	0.634884310366059	NA	NA	p.Cys212Pro	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.246	-4.6	2.354	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212Q	212	C	Q	missense	possibly_wt-like	0.867594255581383	0.262405520972928	4	0.131202760486464	0.610441570355678	1.12474694080709	NA	NA	NA	NA	1.14030566625315	0.789319832642278	0.538892822370796	1.00185870105931	0.652190855684749	NA	NA	NA	NA	0.672715833763858	0.63166587760564	0.596584706930091	0.696977857198382	NA	NA	p.Cys212Gln	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.246	-3.59	1.344	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212R	212	C	R	missense	low	0.36345684441657	0.260855022212426	4	0.130427511106213	0.107823620055196	0.619090068777945	NA	NA	NA	NA	0.191567247276956	0.094118625718157	0.535563405215362	0.632578099455806	0.564948065696732	NA	NA	NA	NA	0.533996302467099	0.498095672087672	0.595899828926364	0.61392610435867	ND	*25	p.Cys212Arg	1	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.246	-4.52	2.274	0.013123605	NA	NA	1.12	0.68	NA	NA	NA
C212S	212	C	S	missense	low	0.413007051058294	0.180533247670548	4	0.0902666238352739	0.236087719335133	0.589926382781456	NA	NA	NA	NA	0.280588136837137	0.234660486561276	0.559819398053022	0.576960182781742	0.573950938746047	NA	NA	NA	NA	0.547012467753981	0.525098221924646	0.600889409738113	0.601417552734197	NA	NA	p.Cys212Ser	1	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.246	-2.958	0.712	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212T	212	C	T	missense	wt-like	1.03224916758175	0.156040658278864	4	0.078020329139432	0.879332132406499	1.18516620275699	NA	NA	NA	NA	1.1986994403836	1.12917152773231	0.875424712737797	0.925700989473277	0.680551869503771	NA	NA	NA	NA	0.681253863652821	0.696962169249966	0.665811024482003	0.67984987535472	NA	NA	p.Cys212Thr	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.246	-2.962	0.716	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212V	212	C	V	missense	wt-like	0.946795960076645	0.0403817634231867	4	0.0201908817115933	0.907222559105813	0.986369361047476	NA	NA	NA	NA	0.958806206228181	0.926513207238048	0.997312204756541	0.904552222083808	0.666559281668569	NA	NA	NA	NA	0.646177939311932	0.658025077011432	0.69088390009832	0.675093486325706	NA	NA	p.Cys212Val	0	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.246	-3.156	0.91	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212W	212	C	W	missense	possibly_low	0.608799762463917	0.22209471515451	8	0.0785223395757243	0.454898804913673	0.762700720014161	0.58504795619573	0.525327924800633	0.832003689308079	0.918947698713259	0.654332873255463	0.175239708131305	0.567776781794195	0.61172146751267	0.602092868622079	0.597894908861094	0.570909694344721	0.667469200782189	0.697491397552736	0.601659453291395	0.513681605399992	0.602526283952762	0.609235417023109	NA	NA	p.Cys212Trp	1	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.246	-2.386	0.14	0.013123605	NA	NA	NA	NA	NA	NA	NA
C212X	212	C	X	nonsense	low	0.065215755432692	0.373299754942653	4	0.186649877471327	-0.300611282129922	0.431042792995306	NA	NA	NA	NA	-0.400420226212953	-0.0446975564631682	0.244519615957441	0.461461188449448	0.503727662231528	NA	NA	NA	NA	0.447439014163448	0.471424679864836	0.53603064459822	0.575441658281933	NA	NA	p.Cys212Ter	1	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C212Y	212	C	Y	missense	wt-like	1.19856794028173	0.0620262762454652	2	0.0438592005449185	1.11260548682297	1.28453039374049	NA	NA	NA	NA	1.15470873973681	1.24242714082665	NA	NA	0.696771970278927	NA	NA	NA	NA	0.67482177525724	0.718722165300614	NA	NA	NA	NA	p.Cys212Tyr	1	36.8	27	10.7	0.813	67.8	-131.7	-116	143.1	0.675675675675676	-3.5	0	1	18.23	0	0	0	0	11	23.6646829149011	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.246	-2.153	-0.093	0.013123605	NA	NA	NA	NA	NA	NA	NA
N213A	213	N	A	missense	wt-like	1.13250133095645	0.137389122813877	4	0.0686945614069384	0.997862464665074	1.26714019724782	NA	NA	NA	NA	1.28771718121917	1.20854028330412	1.01952335323018	1.01422450607232	0.697605895530917	NA	NA	NA	NA	0.694269568549785	0.712211424987505	0.695452846047995	0.69975894501384	NA	NA	p.Asn213Ala	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.495	-2.627	0.132	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213C	213	N	C	missense	wt-like	1.17025991280906	0.0505500201665654	4	0.0252750100832827	1.12072180333694	1.21979802228118	NA	NA	NA	NA	1.1619919590345	1.14833824822347	1.24306645671585	1.12764298726241	0.712955816631777	NA	NA	NA	NA	0.67588668919674	0.700644704276678	0.741436796786103	0.725266928986875	NA	NA	p.Asn213Cys	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.495	-4.495	2	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213D	213	N	D	missense	possibly_wt-like	1.03183005198739	0.411967436704898	4	0.205983718352449	0.628109382614953	1.43555072135984	NA	NA	NA	NA	1.41119930639915	1.00745434342813	1.24267983277089	0.465986725351417	0.692950455513483	NA	NA	NA	NA	0.712324474081047	0.673576436945919	0.741357266278735	0.576459458216772	NA	NA	p.Asn213Asp	1	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.495	-2.4	-0.095	0.011947223	NA	NA	NA	NA	3.23e-05	NA	NA
N213E	213	N	E	missense	possibly_wt-like	0.842830975797529	0.386214724062264	4	0.193107362031132	0.464347501066972	1.22131445052808	NA	NA	NA	NA	0.48534929750556	0.728924012602136	1.39126629721668	0.765784295865743	0.631973149686897	NA	NA	NA	NA	0.576951565473198	0.620061924656708	0.771922256005035	0.643884374717086	NA	NA	p.Asn213Glu	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.495	-2.258	-0.237	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213F	213	N	F	missense	wt-like	0.922594978989791	0.113968371971388	4	0.0569841859856938	0.810908026769499	1.03428193121008	NA	NA	NA	NA	0.763676010767795	0.96044730598838	1.03287649806594	0.93338010113705	0.673060906387647	NA	NA	NA	NA	0.61764703056543	0.664544893863021	0.698199655700146	0.681576918912272	NA	NA	p.Asn213Phe	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.495	-4.825	2.33	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213G	213	N	G	missense	wt-like	1.02676444110571	0.0743236924218303	4	0.0371618462109152	0.953928560933301	1.09960032127812	NA	NA	NA	NA	1.11991350567976	0.939318821682544	1.01313578633625	1.03468965072429	0.681936545323216	NA	NA	NA	NA	0.669734199521702	0.660485441775042	0.694138891124731	0.704361586279273	NA	NA	p.Asn213Gly	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.495	-3.215	0.72	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213H	213	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn213His	1	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.495	-3.015	0.52	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213I	213	N	I	missense	possibly_low	0.484850393881775	0.272018141026625	3	0.157049746946184	0.177038546086126	0.792662241677425	NA	NA	NA	NA	0.457910268780491	0.227304698048839	0.769336214815996	NA	0.572939575310423	NA	NA	NA	NA	0.572939575310423	0.523684941605844	0.643988082122125	NA	NA	NA	p.Asn213Ile	1	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.495	-3.797	1.302	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213K	213	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn213Lys	1	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.495	-2.7	0.205	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213L	213	N	L	missense	low	0.463717116491192	0.144377671220736	4	0.0721888356103678	0.322229598608989	0.605204634373396	NA	NA	NA	NA	0.537087794982339	0.247266486658141	0.540943390870082	0.529570793454206	0.587638052476238	NA	NA	NA	NA	0.584516495886497	0.527520234439767	0.597006519275835	0.59075960906598	NA	NA	p.Asn213Leu	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.495	-3.674	1.179	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213M	213	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn213Met	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.495	-4.122	1.627	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213P	213	N	P	missense	low	0.286152208523864	0.213842765792801	4	0.106921382896401	0.0765901488697018	0.495714268178026	NA	NA	NA	NA	0.17394024917229	0.322065041021092	0.569652695840559	0.0789508480615155	0.536655192626619	NA	NA	NA	NA	0.53141897570733	0.541891409545907	0.602912168991271	0.48941451764528	NA	NA	p.Asn213Pro	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.495	-3.461	0.966	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213Q	213	N	Q	missense	possibly_wt-like	0.915769480683995	0.551884359965672	2	0.390241173362524	0.150910835608796	1.68062812575919	NA	NA	NA	NA	0.525528307321471	1.30601065404652	NA	NA	0.656882451878325	NA	NA	NA	NA	0.582826328525005	0.730938575231645	NA	NA	NA	NA	p.Asn213Gln	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.495	-2.499	0.004	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213R	213	N	R	missense	wt-like	0.984438638655917	0.082182193116263	4	0.0410910965581315	0.903901569316722	1.06497570799511	NA	NA	NA	NA	0.972811500290917	0.92681002292058	1.10394086742692	0.934192163985253	0.66992082888317	NA	NA	NA	NA	0.648225719594881	0.658082104719845	0.712817957088002	0.681759553046495	NA	NA	p.Asn213Arg	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.495	-2.793	0.298	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213S	213	N	S	missense	wt-like	1.04671684855557	0.412337029007687	8	0.145783154672825	0.760987115844199	1.33244658126694	0.30408759374265	0.676163272969783	1.29477737974982	1.51980422044108	1.39223883407441	1.30454232544502	0.878558522541671	1.0035626394801	0.703456624607673	0.538050697280603	0.603522071884076	0.805938031932522	0.896497404379562	0.709552173748896	0.730656462727932	0.66645566506092	0.697361075466449	NA	NA	p.Asn213Ser	1	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.495	-2.445	-0.05	0.011947223	NA	NA	NA	NA	4.06e-06	NA	NA
N213T	213	N	T	missense	possibly_wt-like	0.799036689766454	0.203804046094575	4	0.101902023047287	0.599312394642	0.998760984890908	NA	NA	NA	NA	0.858035317293312	0.707602383092937	1.05215235592942	0.578356702750148	0.623704557146465	NA	NA	NA	NA	0.631443751044856	0.615965363248073	0.702164797476421	0.601731632138173	NA	NA	p.Asn213Thr	1	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.495	-2.471	-0.024	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213V	213	N	V	missense	wt-like	1.09707247067493	0.16960815054998	4	0.0848040752749901	0.930859537393727	1.26328540395614	NA	NA	NA	NA	1.13237432216434	1.22377719622464	1.18321791906622	0.848920445244528	0.693347536874542	NA	NA	NA	NA	0.671556154433343	0.715138919315741	0.72912564889509	0.6625818175296	NA	NA	p.Asn213Val	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.495	-3.361	0.866	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213W	213	N	W	missense	low	0.491367216778856	0.175145326661238	4	0.0875726633306191	0.319727950620591	0.663006482937121	NA	NA	NA	NA	0.271808796758701	0.428974518659194	0.622837743937439	0.641847807760092	0.588142357463368	NA	NA	NA	NA	0.545728798919225	0.562432111658782	0.613852603267955	0.616010875450466	NA	NA	p.Asn213Trp	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.495	-5.958	3.463	0.011947223	NA	NA	NA	NA	NA	NA	NA
N213X	213	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn213Ter	0	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N213Y	213	N	Y	missense	wt-like	1.12585088406709	0.2547207723275	4	0.12736038616375	0.876229114129027	1.37547265400515	NA	NA	NA	NA	1.20479549642122	1.41892960688691	0.810765700569725	1.06891273239051	0.69710180237061	NA	NA	NA	NA	0.682145196837377	0.752633888167733	0.652510337572187	0.712058407903844	NA	NA	p.Asn213Tyr	1	39.6	27.2	13.2	0.725	38.6	-143.9	-73.8	131.2	39.0374331550802	-5.3	0	1	16.72	0	0	0	0	6	25.658147017505	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.495	-4.741	2.246	0.011947223	NA	NA	NA	NA	NA	NA	NA
I214A	214	I	A	missense	possibly_wt-like	0.790799060540761	0.0762630464117917	4	0.0381315232058959	0.716062648381552	0.86553547269997	NA	NA	NA	NA	0.833186870082562	0.684692838506753	0.857030362640009	0.788286170933719	0.638377810859695	NA	NA	NA	NA	0.627810542057444	0.611563712980176	0.66202721332627	0.648945079661946	NA	NA	p.Ile214Ala	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.692	-2.814	1.122	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214C	214	I	C	missense	wt-like	1.59821254269343	0.213641911456116	3	0.123346215089375	1.35645840348893	1.83996668189794	NA	NA	NA	NA	1.84099727392607	1.51469559180545	NA	1.43894476234878	0.7751672676426	NA	NA	NA	NA	0.7751672676426	0.771033571827367	NA	0.795279158090628	NA	NA	p.Ile214Cys	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.692	-3.67	1.978	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214D	214	I	D	missense	low	-0.0304848411436542	0.091049525165487	4	0.0455247625827435	-0.119711736210568	0.0587420539232597	NA	NA	NA	NA	-0.0485884369307131	0.00432969212659679	-0.146521850725711	0.0688412309552107	0.483992609709671	NA	NA	NA	NA	0.498882004062813	0.480844369596229	0.45559143059371	0.487140849823112	NA	NA	p.Ile214Asp	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.692	-3.768	2.076	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214E	214	I	E	missense	low	0.646904017941053	0.0510159161225222	4	0.0255079580612611	0.596909338821823	0.696898697060283	NA	NA	NA	NA	0.575939057224514	0.655019882905117	0.659210854638987	0.697446276995593	0.613598666807047	NA	NA	NA	NA	0.590197122685966	0.60586259690247	0.621334736711624	0.628515053317277	NA	NA	p.Ile214Glu	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.692	-3.69	1.998	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214F	214	I	F	missense	low	0.394633908386864	0.210780833071363	2	0.149044556408911	0.102511945733651	0.686755871040077	NA	NA	NA	NA	0.543678464795775	0.245589351977953	NA	NA	0.556339076277467	NA	NA	NA	NA	0.585480148890491	0.527198003664442	NA	NA	NA	NA	p.Ile214Phe	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.692	-3.259	1.567	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214G	214	I	G	missense	low	0.0942676821668939	0.295182311099896	4	0.147591155549948	-0.195005667147653	0.383541031481441	NA	NA	NA	NA	-0.178203722262204	-0.143951783287739	0.351349221148084	0.347877013069435	0.514913374809911	NA	NA	NA	NA	0.479930340179018	0.452354794278559	0.558006036483987	0.549896409440805	NA	NA	p.Ile214Gly	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.692	-3.599	1.907	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214H	214	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile214His	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.692	-5.281	3.589	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214I	214	I	I	synonymous	wt-like	1.15478197546509	0.0957575738687094	4	0.0478787869343547	1.06094127745029	1.2486226734799	NA	NA	NA	NA	1.20437254331635	1.01309718432852	1.21998713266536	1.18167104155015	0.709386308789172	NA	NA	NA	NA	0.682083354863558	0.674660605689102	0.736689262714785	0.737417918211956	NA	NA	p.Ile214=	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214K	214	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile214Lys	1	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.692	-4.17	2.478	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214L	214	I	L	missense	possibly_wt-like	0.772782636056544	0.219415762526267	4	0.109707881263133	0.557759139960606	0.987806132152482	NA	NA	NA	NA	0.804837285278095	0.711083282567522	1.05138151816567	0.523828458214888	0.620149784822269	NA	NA	NA	NA	0.623665415183825	0.616634154460713	0.702006232236865	0.589468149387492	NA	NA	p.Ile214Leu	1	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.692	-1.979	0.287	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214M	214	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile214Met	1	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.692	-3.082	1.39	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214N	214	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile214Asn	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.692	-4.496	2.804	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214P	214	I	P	missense	low	0.265550997079083	0.160661784382141	4	0.0803308921910707	0.108105341538615	0.422996652619551	NA	NA	NA	NA	0.162245928884901	0.0953465155649571	0.388316716396078	0.416294827470396	0.5474963854016	NA	NA	NA	NA	0.529709093829825	0.498331588679238	0.565610437845016	0.565283676973376	NA	NA	p.Ile214Pro	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.692	-3.285	1.593	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214Q	214	I	Q	missense	low	0.37998798112431	0.247247876394785	4	0.123623938197393	0.137689514630415	0.622286447618205	NA	NA	NA	NA	0.0742674865249552	0.285825176530916	0.556375904140943	0.603483357300426	0.567554823758611	NA	NA	NA	NA	0.516845349678343	0.534928581950551	0.600181065566671	0.607382653866196	NA	NA	p.Ile214Gln	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.692	-3.916	2.224	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214R	214	I	R	missense	low	0.167730762243764	0.236485629137407	4	0.118242814568704	-0.0640208957415427	0.399482420229071	NA	NA	NA	NA	-0.0593041130856229	0.0028768530880714	0.285360715577489	0.44198959339512	0.520873540203641	NA	NA	NA	NA	0.497315214372415	0.480565233128934	0.544431866034868	0.571062467788783	NA	NA	p.Ile214Arg	1	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.692	-3.48	1.788	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214S	214	I	S	missense	possibly_low	0.617613501166425	0.12177360604041	4	0.0608868030202051	0.498277560113039	0.736949442219812	NA	NA	NA	NA	0.580075273131653	0.465795526593922	0.744700950535424	0.679882254404703	0.607683388532598	NA	NA	NA	NA	0.590801898375981	0.569506595345283	0.638920483249987	0.624564878689214	NA	NA	p.Ile214Ser	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.692	-3.414	1.722	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214T	214	I	T	missense	possibly_low	0.680448003340578	0.157154927119904	4	0.0785774635599522	0.526439004766563	0.834457001914592	NA	NA	NA	NA	0.880711318960567	0.497918347115051	0.687601489362883	0.65556085792381	0.623134897515439	NA	NA	NA	NA	0.634759316494773	0.575678408190384	0.627174834340272	0.619094960690606	NA	NA	p.Ile214Thr	1	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.692	-3.211	1.519	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214V	214	I	V	missense	wt-like	0.933214241953601	0.108302765369687	4	0.0541513826848434	0.827079482178262	1.03934900172894	NA	NA	NA	NA	0.814377820161325	0.938209427075884	0.904807530674664	1.07546218990253	0.666063755555204	NA	NA	NA	NA	0.62506038191106	0.660272291878097	0.671855219232311	0.713531390573826	NA	NA	p.Ile214Val	1	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.692	-1.752	0.06	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214W	214	I	W	missense	possibly_wt-like	0.745815708582162	0.0404641044396481	4	0.0202320522198241	0.706161614897973	0.785469802266351	NA	NA	NA	NA	0.77840275157178	0.700131135065784	0.781323608528557	0.723405339162527	0.627076790868251	NA	NA	NA	NA	0.6198002969885	0.614529899493806	0.646453949837842	0.634353284748002	NA	NA	p.Ile214Trp	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.692	-5.707	4.015	0.010009117	NA	NA	NA	NA	NA	NA	NA
I214X	214	I	X	nonsense	low	-0.303345816490131	0.224558292758581	4	0.11227914637929	-0.523408899608441	-0.0832827333718216	NA	NA	NA	NA	-0.352110524747734	-0.595592063387955	-0.184556773314963	-0.0811239045098752	0.450590461662593	NA	NA	NA	NA	0.454502604095405	0.36558036921666	0.447767454012013	0.453413469313174	NA	NA	p.Ile214Ter	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I214Y	214	I	Y	missense	low	-0.134508071076955	0.425724504410399	4	0.212862252205199	-0.551710419067228	0.282694276913317	NA	NA	NA	NA	-0.367354428306351	-0.480903860355404	-0.162499859587235	0.472725863941169	0.452289196975931	NA	NA	NA	NA	0.452273720860059	0.387615611240077	0.452304673091802	0.577975100441353	NA	NA	p.Ile214Tyr	0	39.9	23.5	14.4	0.934	24.3	174.2	-112.7	119.9	21.4659685863874	-1.2	0	1	14.75	0	0	0	0	5	23.6845357911999	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.692	-3.631	1.939	0.010009117	NA	NA	NA	NA	NA	NA	NA
R215A	215	R	A	missense	wt-like	1.1256954735344	0.208124778986753	4	0.104062389493376	0.921736937982208	1.3296540090866	NA	NA	NA	NA	1.2991724670635	1.30739286007699	0.991496894878193	0.904719672118938	0.692816080708944	NA	NA	NA	NA	0.695944500070857	0.731204140857422	0.689687661347031	0.675131146085981	NA	NA	p.Arg215Ala	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.614	-2.678	0.064	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215C	215	R	C	missense	wt-like	1.20555349757763	0.161564991178365	4	0.0807824955891824	1.04722271564157	1.3638842795137	NA	NA	NA	NA	1.19867705184961	1.42480428998131	1.16117292617257	1.03755972230704	0.714798975804779	NA	NA	NA	NA	0.68125059011938	0.753762601151048	0.72459088199136	0.705007069618198	NA	NA	p.Arg215Cys	1	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.614	-4.48	1.866	0.01082453	NA	NA	NA	NA	1.22e-05	NA	NA
R215D	215	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg215Asp	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.614	-2.623	0.009	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215E	215	R	E	missense	possibly_wt-like	0.93534759253523	0.239961689303208	4	0.119980844651604	0.700189458183391	1.17050572688707	NA	NA	NA	NA	1.12064536721322	1.15166604547848	0.660485101841758	0.808593855607462	0.661676758201754	NA	NA	NA	NA	0.669841208457849	0.701284079696119	0.621596855827297	0.65351230794566	NA	NA	p.Arg215Glu	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.614	-2.109	-0.505	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215F	215	R	F	missense	low	0.112081840185516	0.271230451435452	3	0.156594974148682	-0.194838669305881	0.419002349676913	NA	NA	NA	NA	0.317499334264732	-0.195367468615899	NA	0.214113654907715	0.519812832581317	NA	NA	NA	NA	0.552409428501374	0.442476210082028	NA	0.519812832581317	NA	NA	p.Arg215Phe	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.614	-4.129	1.515	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215G	215	R	G	missense	wt-like	1.05221406861837	0.0294103714469077	4	0.0147051857234539	1.02339243421442	1.08103570302231	NA	NA	NA	NA	1.09005867119444	1.04450769907304	1.05516093424548	1.0191289699605	0.690778764092957	NA	NA	NA	NA	0.665368982973168	0.680695561998246	0.702783677302818	0.700861966187668	NA	NA	p.Arg215Gly	1	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.614	-3.336	0.722	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215H	215	R	H	missense	wt-like	1.13632342646093	0.165165150025564	4	0.082582575012782	0.974464553685301	1.29818229923656	NA	NA	NA	NA	1.29478055188045	1.24563847256445	1.06925490024399	0.935619781154834	0.700492607503882	NA	NA	NA	NA	0.695302337380382	0.719339163999599	0.705682877627383	0.682080626256956	rs56161402	*8	p.Arg215His	1	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.614	-3.269	0.655	0.01082453	NA	NA	1.3	1.13	0.00232	19.67375	0.877972757
R215I	215	R	I	missense	wt-like	1.41087578339295	0.183462396114633	4	0.0917311980573164	1.2310859389419	1.590665627844	NA	NA	NA	NA	1.49515313945486	1.62503287216884	1.21995806928754	1.30335905266056	0.750734507955577	NA	NA	NA	NA	0.724599761071768	0.792232863582969	0.736683284230487	0.764785731680667	NA	NA	p.Arg215Ile	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.614	-3.912	1.298	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215K	215	R	K	missense	possibly_low	0.698008873345308	0.302622663094877	4	0.151311331547438	0.401444113059529	0.994573633631086	NA	NA	NA	NA	1.06021445816674	0.630737939697945	0.331989562827115	0.76909353268943	0.622912946145376	NA	NA	NA	NA	0.661005319438185	0.601197265323275	0.554023656528369	0.644628626967476	NA	NA	p.Arg215Lys	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.614	-2.435	-0.179	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215L	215	R	L	missense	wt-like	1.21535101383678	0.176836748329556	4	0.0884183741647781	1.04205418490223	1.38864784277133	NA	NA	NA	NA	1.27400792260968	1.43032901334577	1.13649691857201	1.02057020081966	0.71035050157429	NA	NA	NA	NA	0.692265073010554	0.75482407576857	0.719514902011553	0.701186101137027	NA	NA	p.Arg215Leu	1	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.614	-3.16	0.546	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215M	215	R	M	missense	possibly_wt-like	0.790523660462855	0.155524162199116	4	0.0777620810995581	0.638112782144838	0.942934538780872	NA	NA	NA	NA	0.61241414219373	0.95562545109225	0.714877987379145	0.879177061186296	0.648202105484862	NA	NA	NA	NA	0.595530317368225	0.663618462575159	0.632785748394565	0.669386575153072	NA	NA	p.Arg215Met	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.614	-4.33	1.716	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215N	215	R	N	missense	wt-like	1.12626707132107	0.125347906778442	4	0.0626739533892209	1.00342837990945	1.24910576273268	NA	NA	NA	NA	1.20681062592178	1.25110596421258	1.06814772753399	0.979003967615922	0.698646460233146	NA	NA	NA	NA	0.68243983845221	0.720389642588868	0.705455126582679	0.691837793883614	NA	NA	p.Arg215Asn	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.614	-2.743	0.129	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215P	215	R	P	missense	possibly_low	0.576812799100866	0.546234835412619	4	0.273117417706309	0.0415124968459175	1.11211310135581	NA	NA	NA	NA	0.00450705688872405	0.312460838139023	1.26689853494399	0.723384766431722	0.587197397705675	NA	NA	NA	NA	0.506645347329286	0.540046137500897	0.746339176211556	0.634348657910452	NA	NA	p.Arg215Pro	1	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.614	-4.413	1.799	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215Q	215	R	Q	missense	wt-like	1.06873940002549	0.207871313560365	4	0.103935656780182	0.865029256026821	1.27244954402417	NA	NA	NA	NA	1.29417875903463	1.06077213319245	0.794024422089196	1.12598228578571	0.689517411073381	NA	NA	NA	NA	0.695214346402214	0.683820475744548	0.649066571636501	0.724893434771407	NA	NA	p.Arg215Gln	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.614	-2.418	-0.196	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215R	215	R	R	synonymous	wt-like	1.15046392074327	0.1525818950475	4	0.0762909475237498	1.00093641125029	1.29999143023626	NA	NA	NA	NA	1.34423383957125	1.17624123716271	1.10205787742425	0.979322728814887	0.704269445036683	NA	NA	NA	NA	0.702533136462972	0.706005753610394	0.712430616489376	0.691909483748168	NA	NA	p.Arg215=	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215S	215	R	S	missense	possibly_wt-like	0.907617949511901	0.237933217245727	4	0.118966608622863	0.674447681248217	1.14078821777559	NA	NA	NA	NA	1.10324676648546	1.12383909342294	0.703148194432631	0.700237743706577	0.64883507361118	NA	NA	NA	NA	0.667297276758763	0.695937639459856	0.630372870463596	0.629142858304417	NA	NA	p.Arg215Ser	1	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.614	-2.941	0.327	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215T	215	R	T	missense	wt-like	0.974562227645874	0.195879044211669	4	0.0979395221058344	0.782604291655374	1.16652016363637	NA	NA	NA	NA	1.15050582241284	1.11054156550822	0.910826877667089	0.726374644995352	0.67365033814547	NA	NA	NA	NA	0.674207246837604	0.693382762513787	0.673093429453335	0.635021086016367	NA	NA	p.Arg215Thr	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.614	-2.406	-0.208	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215V	215	R	V	missense	possibly_low	0.689061559192639	0.12769566372725	4	0.063847831863625	0.563922108248965	0.814201010136313	NA	NA	NA	NA	0.608809331458411	0.555627122088526	0.765553753430807	0.826256029792811	0.619106625781532	NA	NA	NA	NA	0.595003240941662	0.586766094541652	0.643210010621402	0.657484557012315	NA	NA	p.Arg215Val	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.614	-3.025	0.411	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215W	215	R	W	missense	wt-like	0.940799506603379	0.0995214044649781	4	0.0497607022324891	0.843270322382279	1.03832869082448	NA	NA	NA	NA	0.950354895724289	0.879194348525693	1.07744183919189	0.856206942971648	0.656577092401519	NA	NA	NA	NA	0.644942233232686	0.64893362317025	0.707366972512915	0.664220561632789	NA	NA	p.Arg215Trp	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.614	-5.886	3.272	0.01082453	NA	NA	NA	NA	NA	NA	NA
R215X	215	R	X	nonsense	low	0.00255237683188275	0.393416207926396	2	0.278187268453452	-0.542684650294458	0.547789403958223	NA	NA	NA	NA	-0.275634891621569	0.280739645285334	NA	NA	0.499817979088855	NA	NA	NA	NA	0.46568446810628	0.53395149007143	NA	NA	NA	NA	p.Arg215Ter	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R215Y	215	R	Y	missense	wt-like	1.08579489009822	0.223025644550277	4	0.111512822275139	0.867233774624529	1.3043560055719	NA	NA	NA	NA	1.10400799319388	1.03109375283265	1.37351218463372	0.834565629732614	0.672763448357366	NA	NA	NA	NA	0.667408579316022	0.67811831739871	0.768270144954937	0.659353398314568	NA	NA	p.Arg215Tyr	0	40.7	22.6	18	0.986	19.8	-154.1	-121.3	129.7	49.0566037735849	-6	0	1	13.9	0	0	0	0	6	24.2307407910074	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.614	-3.887	1.273	0.01082453	NA	NA	NA	NA	NA	NA	NA
C216A	216	C	A	missense	possibly_wt-like	0.802462277230589	0.153807466169411	4	0.0769037330847057	0.651733730107884	0.953190824353293	NA	NA	NA	NA	0.749565397028567	0.61174418357864	0.891676735577155	0.956862792737993	0.642368999522042	NA	NA	NA	NA	0.615583850994472	0.597547962239297	0.669154148049613	0.686858210944359	NA	NA	p.Cys216Ala	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.715	-2.676	-0.039	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216D	216	C	D	missense	possibly_low	0.653685138265853	0.141800903859982	4	0.0709004519299911	0.514722805995457	0.792647470536249	NA	NA	NA	NA	0.808482572475644	0.508443881462203	0.561672995354072	0.736141103771493	0.612734556987115	NA	NA	NA	NA	0.624198409865364	0.577700697236969	0.601270704108866	0.637217577023133	NA	NA	p.Cys216Asp	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.715	-3.57	0.855	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216E	216	C	E	missense	wt-like	1.09545589119564	0.315982708770471	4	0.157991354385235	0.78579852673187	1.4051132556594	NA	NA	NA	NA	0.919253334593254	1.56887318650895	0.936958127073587	0.956738916606749	0.682649555538284	NA	NA	NA	NA	0.640394726884887	0.781442806430157	0.678468760057129	0.686830351019439	NA	NA	p.Cys216Glu	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.715	-2.8	0.085	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216F	216	C	F	missense	possibly_wt-like	1.14523912943205	0.633092210959627	3	0.365515958419396	0.428841015155394	1.86163724370871	NA	NA	NA	NA	0.421804812509857	1.59799385927024	NA	1.41591871651606	0.787037811454322	NA	NA	NA	NA	0.567660425788342	0.787037811454322	NA	0.79010056636642	NA	NA	p.Cys216Phe	1	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.715	-3.315	0.6	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216G	216	C	G	missense	wt-like	0.910626983574661	0.0643575566090563	4	0.0321787783045282	0.847557737031286	0.973696230118035	NA	NA	NA	NA	0.887866577353346	0.835679084708232	0.987022062034814	0.93194021020225	0.660913022941302	NA	NA	NA	NA	0.635805520665175	0.640572960568723	0.688767165523977	0.681253085313882	NA	NA	p.Cys216Gly	1	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.715	-3.458	0.743	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216H	216	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys216His	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.715	-3.087	0.372	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216I	216	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys216Ile	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.715	-3	0.285	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216K	216	C	K	missense	wt-like	1.34959433177795	0.174117527712045	4	0.0870587638560223	1.17896229008157	1.52022637347433	NA	NA	NA	NA	1.45592459660694	1.47293101170447	1.09681299646079	1.37270872233961	0.740936620697397	NA	NA	NA	NA	0.718863970290583	0.763009271104211	0.711351717860473	0.780382574841913	NA	NA	p.Cys216Lys	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.715	-2.798	0.083	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216L	216	C	L	missense	wt-like	1.04969958950044	0.127231320488919	4	0.0636156602444593	0.925015186568568	1.17438399243232	NA	NA	NA	NA	1.0647269255637	1.22055331905768	0.987342742939432	0.926175370440971	0.684394847774242	NA	NA	NA	NA	0.661665108638008	0.714519510241841	0.688833131213326	0.679956564335159	NA	NA	p.Cys216Leu	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.715	-2.169	-0.546	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216M	216	C	M	missense	wt-like	1.36289257987997	0.215379978139984	4	0.107689989069992	1.15182407980727	1.57396107995266	NA	NA	NA	NA	1.63873197632103	1.40986886869002	1.26769076903902	1.1352787054698	0.746047622325546	NA	NA	NA	NA	0.745593101866063	0.75089303292892	0.746502142785029	0.72698421329198	NA	NA	p.Cys216Met	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.715	-3.596	0.881	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216N	216	C	N	missense	wt-like	1.07967472664962	0.114353160361192	4	0.0571765801805958	0.967610688736487	1.19173876456276	NA	NA	NA	NA	1.19071583050273	0.958824050678679	1.00632732624177	1.16283169917531	0.68641244931399	NA	NA	NA	NA	0.680086542293657	0.664233015023966	0.692738356334324	0.73318092228045	NA	NA	p.Cys216Asn	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.715	-3.379	0.664	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216P	216	C	P	missense	wt-like	1.34906952704182	0.204761991609751	4	0.102380995804875	1.14840646256292	1.54973259152072	NA	NA	NA	NA	1.18727484287334	1.24446881764805	1.64533214730057	1.31920230034533	0.743731668837885	NA	NA	NA	NA	0.679583419218213	0.719114436185531	0.824184890603567	0.768348901490239	NA	NA	p.Cys216Pro	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.715	-3.273	0.558	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216Q	216	C	Q	missense	wt-like	1.02241987908295	0.178434444773712	4	0.089217222386856	0.847557336404014	1.19728242176189	NA	NA	NA	NA	1.03778126429884	1.23372732093242	1.02075544255126	0.79741548854929	0.676715774569224	NA	NA	NA	NA	0.657725256064972	0.717050653917048	0.695706293073477	0.65099827668045	NA	NA	p.Cys216Gln	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.715	-3.1	0.385	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216R	216	C	R	missense	wt-like	0.99678002759423	0.078462239993239	4	0.0392311199966195	0.919888445327687	1.07367160986077	NA	NA	NA	NA	1.11306327232031	0.943550138885922	0.957319485274913	0.973187213895773	0.67569489463261	NA	NA	NA	NA	0.66873259450404	0.661298412038669	0.68265719476118	0.690529597378848	NA	NA	p.Cys216Arg	1	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.715	-2.876	0.161	0.010904755	NA	NA	NA	NA	4.06e-06	NA	NA
C216S	216	C	S	missense	possibly_wt-like	0.997478686744935	0.363284842670401	4	0.1816424213352	0.641466082863293	1.35349129062658	NA	NA	NA	NA	1.01547019751775	0.533096803858745	1.42107499676504	1.02027274883821	0.677791126608846	NA	NA	NA	NA	0.65446304947072	0.582437305686908	0.77805405676393	0.701119203746971	NA	NA	p.Cys216Ser	1	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.715	-3.231	0.516	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216T	216	C	T	missense	wt-like	0.947865791427562	0.202353927600656	4	0.101176963800328	0.749562586313807	1.14616899654132	NA	NA	NA	NA	1.13594452125301	0.906136616719309	1.06836252348015	0.681019504257782	0.663094128849709	NA	NA	NA	NA	0.672078170127353	0.654110087572065	0.705499311198769	0.624820647861234	NA	NA	p.Cys216Thr	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.715	-2.856	0.141	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216V	216	C	V	missense	wt-like	0.975316222836707	0.111642325571588	4	0.0558211627857942	0.865908754201403	1.08472369147201	NA	NA	NA	NA	1.0107508732731	1.01041617083854	1.06736121875714	0.812736628478052	0.664294760816521	NA	NA	NA	NA	0.653773014752866	0.674145497948658	0.705293337736207	0.654444023684383	NA	NA	p.Cys216Val	0	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.715	-2.685	-0.03	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216W	216	C	W	missense	possibly_wt-like	0.854746015309812	0.258904582168383	4	0.129452291084192	0.601024187068601	1.10846784355102	NA	NA	NA	NA	1.15937230202964	0.552819437786563	0.760837338838978	0.945954982584062	0.658871738481598	NA	NA	NA	NA	0.675503656756392	0.586226649319883	0.642239820206804	0.684405028326607	NA	NA	p.Cys216Trp	1	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.715	-4.298	1.583	0.010904755	NA	NA	NA	NA	NA	NA	NA
C216X	216	C	X	nonsense	possibly_low	0.450510188662953	0.404334233236788	4	0.202167116618394	0.0542699212325919	0.846750456093314	NA	NA	NA	NA	0.0704933141336398	0.281309062568936	1.01373352021848	0.436504857730752	0.551944917915162	NA	NA	NA	NA	0.516293510083061	0.534060893195071	0.694261848017457	0.569828942635254	rs398122996	*37	p.Cys216Ter	1	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C216Y	216	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys216Tyr	1	40.8	19	19.3	0.906	18.6	175.8	-100.4	106	42.5675675675676	-1	0	1	13.76	0	0	0	0	6	23.0288218466475	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.715	-3.598	0.883	0.010904755	NA	NA	NA	NA	NA	NA	NA
L217A	217	L	A	missense	possibly_wt-like	0.742321219362177	0.108506297593351	4	0.0542531487966756	0.635987001672801	0.848655437051554	NA	NA	NA	NA	0.881660655000223	0.622769381734298	0.759044662237246	0.705810178476943	0.632647115261729	NA	NA	NA	NA	0.634898123407016	0.599666252554187	0.641871057533038	0.630396107116443	NA	NA	p.Leu217Ala	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.327	-2.915	1.588	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217C	217	L	C	missense	wt-like	1.01276700935717	0.0872333424852957	4	0.0436166712426478	0.927279904596053	1.09825411411828	NA	NA	NA	NA	1.12559855564208	0.923953567209378	1.03175592590847	0.969759988668737	0.680162123463188	NA	NA	NA	NA	0.670565437564137	0.6575332889632	0.697969148321103	0.68975880936224	NA	NA	p.Leu217Cys	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.327	-3.737	2.41	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217D	217	L	D	missense	low	0.288112081901293	0.154584435786286	4	0.0772922178931429	0.136622118545511	0.439602045257076	NA	NA	NA	NA	0.254362755059874	0.11451966310431	0.489046510829314	0.294519398611675	0.540537066887657	NA	NA	NA	NA	0.543177930651387	0.50201535854579	0.586331067704996	0.537896203123928	NA	NA	p.Leu217Asp	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.327	-3.655	2.328	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217E	217	L	E	missense	possibly_low	0.635719759900294	0.139392707030911	4	0.0696963535154553	0.49911741715623	0.772322102644358	NA	NA	NA	NA	0.55481327048634	0.504612793576209	0.819447884325307	0.664005091213321	0.604051151362337	NA	NA	NA	NA	0.587108221492571	0.576964623721571	0.654296306827738	0.620994081232103	NA	NA	p.Leu217Glu	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.327	-3.208	1.881	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217F	217	L	F	missense	possibly_wt-like	0.780260103703459	0.0668412385851529	4	0.0334206192925764	0.714756893548984	0.845763313857933	NA	NA	NA	NA	0.841519856095318	0.690797483537211	0.819353886232987	0.769369188948318	0.636859784910277	NA	NA	NA	NA	0.629028947353225	0.612736608946425	0.654276970943163	0.644690622467328	NA	NA	p.Leu217Phe	1	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.327	-4.253	2.926	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217G	217	L	G	missense	low	0.216392965698074	0.242703395564641	4	0.121351697782321	-0.0214519914180633	0.454237922814212	NA	NA	NA	NA	0.0398305449255681	-0.0157042277772392	0.484637085964923	0.356808459679045	0.531857633277669	NA	NA	NA	NA	0.511810161577585	0.476995218052426	0.585424026635127	0.551905104977753	NA	NA	p.Leu217Gly	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.327	-3.495	2.168	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217H	217	L	H	missense	low	0.303699876677751	0.406289652337565	4	0.203144826168783	-0.094456666258713	0.701856419614214	NA	NA	NA	NA	0.0762441287997668	-0.13940430277042	0.744599690830072	0.533359989851583	0.554373084413706	NA	NA	NA	NA	0.517134363893873	0.453228509544352	0.638899653614762	0.591611804933539	NA	NA	p.Leu217His	1	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.327	-5.24	3.913	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217I	217	L	I	missense	wt-like	0.898145614400218	0.153469568874882	4	0.076734784437441	0.747748200541389	1.04854302825905	NA	NA	NA	NA	1.03024441545982	0.80157797384597	0.733322066690999	1.02743800160409	0.646601523426335	NA	NA	NA	NA	0.656623257750692	0.634021055392355	0.636579789101978	0.702730679679262	NA	NA	p.Leu217Ile	1	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.327	-2.205	0.878	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217K	217	L	K	missense	wt-like	1.11082791684291	0.25502208673047	4	0.127511043365235	0.860910864215923	1.36074496946989	NA	NA	NA	NA	1.18032833245562	1.1587752602034	0.751203264167282	1.35300481054534	0.690608861222433	NA	NA	NA	NA	0.678567737076517	0.702649985368349	0.640258042159516	0.775951135970746	NA	NA	p.Leu217Lys	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.327	-3.52	2.193	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217L	217	L	L	synonymous	wt-like	1.05042862602072	0.140450481982858	4	0.0702252409914288	0.912789682871878	1.18806756916957	NA	NA	NA	NA	1.2109158830817	0.869636983838337	1.04428508174456	1.0768765554183	0.691793273386067	NA	NA	NA	NA	0.683040087517374	0.647097350228279	0.70054645925476	0.713849483467768	NA	NA	p.Leu217=	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217M	217	L	M	missense	wt-like	1.02805636876423	0.134231998431828	4	0.0671159992159138	0.896511427514624	1.15960131001384	NA	NA	NA	NA	1.20339467005855	0.989297389043212	0.880766852729283	1.03876656322589	0.67601414270521	NA	NA	NA	NA	0.681940375389683	0.670087910020737	0.666909929786502	0.705278489923716	NA	NA	p.Leu217Met	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.327	-3.392	2.065	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217N	217	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu217Asn	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.327	-4.423	3.096	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217P	217	L	P	missense	low	0.14490928572061	0.310190446842819	4	0.15509522342141	-0.159071766359546	0.448890337800766	NA	NA	NA	NA	-0.107662138688945	-0.13752076102575	0.380929891575804	0.443890151021332	0.527167744617663	NA	NA	NA	NA	0.490244558739676	0.453590397664555	0.56409093049565	0.571489906006616	NA	NA	p.Leu217Pro	1	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.327	-4.449	3.122	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217Q	217	L	Q	missense	wt-like	0.843612905813457	0.079158408344116	4	0.039579204172058	0.766039091099466	0.921186720527448	NA	NA	NA	NA	0.750561430831315	0.820936765946392	0.863208344447665	0.939745082028455	0.650519274501002	NA	NA	NA	NA	0.615729485807513	0.637740493468237	0.663298055533766	0.68300841251775	NA	NA	p.Leu217Gln	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.327	-3.763	2.436	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217R	217	L	R	missense	low	0.467901214321851	0.0926304894408404	4	0.0463152447204202	0.377125002734669	0.558677425909034	NA	NA	NA	NA	0.488909896523659	0.33185053228168	0.534715734760505	0.51612869372156	0.582604319236775	NA	NA	NA	NA	0.577472177495487	0.543771512839389	0.595725458812366	0.587736460978063	NA	NA	p.Leu217Arg	1	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.327	-3.159	1.832	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217S	217	L	S	missense	possibly_low	0.659385025563442	0.150790699341878	4	0.075395349670939	0.511612855606597	0.807157195520286	NA	NA	NA	NA	0.78667340726714	0.450961618072466	0.75133059755039	0.64857447936377	0.619266651252622	NA	NA	NA	NA	0.621009588673784	0.5666565309465	0.640284235282564	0.61752371383146	NA	NA	p.Leu217Ser	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.327	-3.957	2.63	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217T	217	L	T	missense	possibly_low	0.615838011568982	0.137090345318131	4	0.0685451726590657	0.481491941843133	0.75018408129483	NA	NA	NA	NA	0.800945747643526	0.627969832374045	0.481739282266645	0.55269718399171	0.598313096278508	NA	NA	NA	NA	0.623096415061247	0.600665424094482	0.584827933709725	0.595960768462535	NA	NA	p.Leu217Thr	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.327	-3.236	1.909	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217V	217	L	V	missense	wt-like	0.944377731464384	0.104158449855769	4	0.0520792249278844	0.84230432626297	1.0464511366658	NA	NA	NA	NA	1.06953855541747	0.864513251711457	0.990568144660991	0.852890974067616	0.662921717561558	NA	NA	NA	NA	0.662368639795532	0.646112918748025	0.689496612714486	0.663474795327584	NA	NA	p.Leu217Val	1	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.327	-1.975	0.648	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217W	217	L	W	missense	wt-like	1.20723795156251	0.124767656588107	4	0.0623838282940534	1.08496789488843	1.32950800823659	NA	NA	NA	NA	1.31757742419233	1.11381313837095	1.31203885907009	1.08552238461667	0.707214759562945	NA	NA	NA	NA	0.698635575898906	0.694011335443883	0.755624769945158	0.715793943226985	NA	NA	p.Leu217Trp	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.327	-3.563	2.236	0.008727872	NA	NA	NA	NA	NA	NA	NA
L217X	217	L	X	nonsense	low	0.507801908263414	0.138434865998904	4	0.0692174329994518	0.372138232482175	0.643465584044654	NA	NA	NA	NA	0.416389319011034	0.36696733761569	0.589774156114867	0.658076820312066	0.586959928172848	NA	NA	NA	NA	0.566868600871303	0.550518565144363	0.607051255474393	0.619660804348562	NA	NA	p.Leu217Ter	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L217Y	217	L	Y	missense	wt-like	1.16129127170581	0.230662584290534	4	0.115331292145267	0.935246092810619	1.387336450601	NA	NA	NA	NA	1.32306540148098	0.87486528040518	1.07590815987666	1.37132624506042	0.703244742954456	NA	NA	NA	NA	0.699437999013668	0.648101871854517	0.707051486895243	0.780071653659485	NA	NA	p.Leu217Tyr	0	40.1	19.4	23	0.754	58.3	16.3	-83.2	-29.1	23.0366492146597	-3.5	0	1	14.5	0	0	0	0	6	23.6995887806498	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.327	-4.442	3.115	0.008727872	NA	NA	NA	NA	NA	NA	NA
E218A	218	E	A	missense	wt-like	1.00631698904691	0.211673170940229	4	0.105836585470115	0.798881093278788	1.21375288481503	NA	NA	NA	NA	1.22474122494381	0.731383760248921	0.965569552104629	1.10357341889027	0.684707915755163	NA	NA	NA	NA	0.685061556137986	0.620534520209522	0.684354275372339	0.719853647501952	NA	NA	p.Glu218Ala	1	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.808	-2.255	0.447	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218C	218	E	C	missense	wt-like	1.12248035772246	0.185010863987116	4	0.0925054319935582	0.941173042640769	1.30378767280416	NA	NA	NA	NA	1.22142358617896	1.00650582723342	1.33012181391698	0.931870203560491	0.682906904600067	NA	NA	NA	NA	0.684576468483406	0.673394196895409	0.759344525517631	0.681237340716729	NA	NA	p.Glu218Cys	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.808	-4.356	2.548	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218D	218	E	D	missense	low	0.51544865866282	0.116589905919862	4	0.058294952959931	0.401192650380899	0.629704666944742	NA	NA	NA	NA	0.456453143032681	0.678082104926549	0.515970401433124	0.411288985258928	0.582297985344315	NA	NA	NA	NA	0.572726522063359	0.61029358134902	0.59186944862527	0.564157855664874	NA	NA	p.Glu218Asp	1	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.808	-2.49	0.682	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218F	218	E	F	missense	possibly_wt-like	0.893243217721574	0.178306241162001	4	0.0891531205810005	0.718506312273456	1.06798012316969	NA	NA	NA	NA	0.980041555649482	0.628377333062788	0.951966654653213	1.01258732752081	0.6654194752616	NA	NA	NA	NA	0.649282860183403	0.600743717903816	0.681556090339798	0.699390741138998	NA	NA	p.Glu218Phe	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.808	-4.005	2.197	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218G	218	E	G	missense	possibly_low	0.591567036870368	0.223563226525293	4	0.111781613262647	0.372479100741796	0.81065497299894	NA	NA	NA	NA	0.500367845339579	0.382269843181278	0.5795347590347	0.904095699925912	0.592046228959127	NA	NA	NA	NA	0.579147498382231	0.553458661900494	0.604944959536023	0.674990813817974	NA	NA	p.Glu218Gly	1	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.808	-2.688	0.88	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218H	218	E	H	missense	wt-like	1.02634223016087	0.0871570141131309	4	0.0435785070565655	0.940929925829981	1.11175453449177	NA	NA	NA	NA	0.950150111384636	0.964124093192613	1.13758305921859	1.05351165684766	0.686923002292414	NA	NA	NA	NA	0.644912290745857	0.665251321322617	0.719738326654085	0.708594683262212	NA	NA	p.Glu218His	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.808	-3.141	1.333	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218I	218	E	I	missense	possibly_low	0.638368831759823	0.123776757922068	4	0.0618883789610342	0.517069837934629	0.759667825585016	NA	NA	NA	NA	0.770121057489947	0.686712103023962	0.619205293510565	0.477436873014817	0.612528533766527	NA	NA	NA	NA	0.618589391328524	0.61195167775048	0.613105389782575	0.579034613341601	NA	NA	p.Glu218Ile	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.808	-3.823	2.015	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218K	218	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu218Lys	1	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.808	-2.928	1.12	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218L	218	E	L	missense	possibly_wt-like	0.787143235848025	0.0902455467631247	4	0.0451227733815623	0.6987042251376	0.87558224655845	NA	NA	NA	NA	0.687510227880246	0.828763122593776	0.741681468408356	0.890618124509723	0.638771772653897	NA	NA	NA	NA	0.60651047122338	0.63924418485346	0.638299360454335	0.67195968719642	NA	NA	p.Glu218Leu	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.808	-3.063	1.255	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218M	218	E	M	missense	wt-like	1.06908657059567	0.142484072352976	2	0.100751453771864	0.871617349812761	1.26655579137857	NA	NA	NA	NA	1.16983802436753	0.968335116823802	NA	NA	0.671547146032153	NA	NA	NA	NA	0.677033899517047	0.666060392547259	NA	NA	NA	NA	p.Glu218Met	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.808	-4.237	2.429	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218N	218	E	N	missense	wt-like	0.856710460381489	0.10592070513902	4	0.0529603525695099	0.752910076736706	0.960510844026272	NA	NA	NA	NA	0.895655829080444	0.778959096302574	0.763546548338863	0.988680367804075	0.639870771174025	NA	NA	NA	NA	0.636944423999459	0.629675251484125	0.642797118348592	0.694014030580898	NA	NA	p.Glu218Asn	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.808	-3.533	1.725	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218P	218	E	P	missense	low	0.489952250157856	0.1851440880813	4	0.0925720440406499	0.308514377862926	0.671390122452785	NA	NA	NA	NA	0.578719330783257	0.407143575088111	0.277115503452697	0.696830591307357	0.574420667247165	NA	NA	NA	NA	0.590603639632293	0.558237694862036	0.542735784061147	0.628376584696438	NA	NA	p.Glu218Pro	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.808	-3.471	1.663	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218Q	218	E	Q	missense	possibly_wt-like	0.835287040136701	0.227836764801479	4	0.113918382400739	0.612011113454191	1.05856296681921	NA	NA	NA	NA	0.963942617476245	0.529029726088685	0.802408440715549	1.04576737626633	0.648860082552561	NA	NA	NA	NA	0.646928958293168	0.581655891028542	0.650791206811955	0.706852983118827	NA	NA	p.Glu218Gln	1	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.808	-2.673	0.865	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218R	218	E	R	missense	low	0.558256054299805	0.0623554315268226	4	0.0311777157634113	0.497148854283292	0.619363254316318	NA	NA	NA	NA	0.531737722797399	0.484906497109202	0.625429814204488	0.590950183088132	0.594149080499867	NA	NA	NA	NA	0.583734236529171	0.573178419033087	0.614385805275134	0.604563924470564	NA	NA	p.Glu218Arg	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.808	-3.446	1.638	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218S	218	E	S	missense	low	0.361719891743016	0.227257735251139	4	0.113628867625569	0.139011403592831	0.584428379893202	NA	NA	NA	NA	0.1144445539634	0.259933645661946	0.642341935587609	0.43015943175911	0.549177922240579	NA	NA	NA	NA	0.522719828725955	0.529953997521038	0.617864714462812	0.568401846960119	NA	NA	p.Glu218Ser	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.808	-2.727	0.919	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218T	218	E	T	missense	wt-like	0.871674235048293	0.0878328621546842	4	0.0439164310773421	0.785599611807167	0.957748858289419	NA	NA	NA	NA	0.914226557523492	0.797180549754777	0.975033990136209	0.800255842778692	0.64564840728904	NA	NA	NA	NA	0.639659738035375	0.633176170726218	0.686301158301948	0.651637076542704	NA	NA	p.Glu218Thr	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.808	-3.315	1.507	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218V	218	E	V	missense	wt-like	0.782757769259524	0.0437655403983665	4	0.0218827701991832	0.739868327787159	0.82564721073189	NA	NA	NA	NA	0.842523396965666	0.756660359794542	0.78744676497333	0.74440055530456	0.634125409842376	NA	NA	NA	NA	0.629175679810126	0.62539095682453	0.647713514189986	0.639075139874627	NA	NA	p.Glu218Val	1	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.808	-3.098	1.29	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218W	218	E	W	missense	possibly_wt-like	0.778276194668934	0.122106459387163	4	0.0610532296935817	0.658614063329663	0.897938326008206	NA	NA	NA	NA	0.862867553264118	0.776419901679414	0.606240622623183	0.867576701109023	0.630668843383541	NA	NA	NA	NA	0.632150295120207	0.629187391646875	0.610438491192884	0.666777637034454	NA	NA	p.Glu218Trp	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.808	-4.426	2.618	0.008357315	NA	NA	NA	NA	NA	NA	NA
E218X	218	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu218Ter	1	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E218Y	218	E	Y	missense	wt-like	1.02823547019752	0.131573028625008	4	0.0657865143125041	0.899296271476586	1.15717466891846	NA	NA	NA	NA	1.06953211839779	1.09252259640929	0.83310214291522	1.11778502306779	0.676144222773876	NA	NA	NA	NA	0.66236769860844	0.689920746939311	0.657105057107096	0.723049858276312	NA	NA	p.Glu218Tyr	0	39.9	15.8	24.1	0.995	44	-176	-147.4	146.6	14.4859813084112	-3.3	0	1	15.64	1	167	1	167	6	22.905772579479	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.808	-3.594	1.786	0.008357315	NA	NA	NA	NA	NA	NA	NA
K219A	219	K	A	missense	wt-like	0.924962259797607	0.125867177808081	4	0.0629335889040407	0.801614692127838	1.04830982746738	NA	NA	NA	NA	1.10639496688083	0.815447799234354	0.885112250722438	0.892894022352806	0.667780695116021	NA	NA	NA	NA	0.667757590027983	0.636685888837943	0.667803800204059	0.672471539983518	NA	NA	p.Lys219Ala	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.36	-2.69	0.33	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219C	219	K	C	missense	wt-like	2.02763074030293	0.287150805571825	3	0.165786594894911	1.70269498518937	2.35256649541648	NA	NA	NA	NA	2.33672547833223	1.97701083316673	1.76915590940983	NA	0.849656066802946	NA	NA	NA	NA	0.847650032955313	0.85985899558624	0.849656066802946	NA	NA	NA	p.Lys219Cys	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.36	-3.891	1.531	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219D	219	K	D	missense	low	0.608081544484534	0.111863320941377	4	0.0559316604706884	0.498457504366463	0.717705584602606	NA	NA	NA	NA	0.604159703569095	0.638366841542787	0.729547712334547	0.460251920491708	0.598493208117339	NA	NA	NA	NA	0.594323396857551	0.602663019377127	0.635803385258205	0.575169692131784	NA	NA	p.Lys219Asp	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.36	-2.92	0.56	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219E	219	K	E	missense	wt-like	1.33308446054131	0.226755119177458	4	0.113377559588729	1.11086852709235	1.55530039399026	NA	NA	NA	NA	1.5778136414179	1.47407050392276	1.13329508433509	1.14715861248947	0.733170982968769	NA	NA	NA	NA	0.736685944006619	0.76322820370713	0.718856268461574	0.729656021930919	NA	NA	p.Lys219Glu	1	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.36	-2.249	-0.111	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219F	219	K	F	missense	possibly_wt-like	0.827559010755206	0.210196499210206	4	0.105098249605103	0.621570226691003	1.03354779481941	NA	NA	NA	NA	0.759437228520352	0.58165811772535	1.07979313490093	0.889347561874188	0.644350596974197	NA	NA	NA	NA	0.617027258165711	0.59176747457727	0.707850645971723	0.671673935782683	NA	NA	p.Lys219Phe	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.36	-4.085	1.725	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219G	219	K	G	missense	wt-like	0.915161568134829	0.0981745952826294	4	0.0490872976413147	0.818952232659454	1.0113709036102	NA	NA	NA	NA	0.85385699037997	0.862795424234132	1.06131034541038	0.882683512514833	0.657979025416216	NA	NA	NA	NA	0.63083281810546	0.645782869595484	0.704048642384119	0.670175181236949	NA	NA	p.Lys219Gly	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.36	-3.389	1.029	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219H	219	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys219His	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.36	-3.446	1.086	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219I	219	K	I	missense	possibly_low	0.34528369916073	0.705853732407154	3	0.407524842413773	-0.453450314775625	1.14401771309709	NA	NA	NA	NA	-0.31063220931911	0.254242569504981	1.09224073729632	NA	0.528860561254914	NA	NA	NA	NA	0.460567344765912	0.528860561254914	0.710411180948789	NA	NA	NA	p.Lys219Ile	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.36	-3.7	1.34	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219L	219	K	L	missense	possibly_wt-like	0.79832548082629	0.21101022285851	4	0.105505111429255	0.591539262240065	1.00511169941251	NA	NA	NA	NA	0.725199027405059	0.695991812111537	1.11228900237241	0.659822081416153	0.616893960196447	NA	NA	NA	NA	0.612021128851076	0.613734604243744	0.714535210808214	0.62005331614915	NA	NA	p.Lys219Leu	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.36	-3.923	1.563	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219M	219	K	M	missense	possibly_low	0.696730598942651	0.272440708998714	4	0.136220354499357	0.429743610162633	0.96371758772267	NA	NA	NA	NA	0.783400277165311	0.622465989072826	1.01423164174401	0.366824487788461	0.610069485020404	NA	NA	NA	NA	0.620531008841327	0.59960796119948	0.694364314142934	0.554157724496262	NA	NA	p.Lys219Met	1	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.36	-4.278	1.918	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219N	219	K	N	missense	possibly_low	0.71395188583967	0.319399585316233	4	0.159699792658116	0.400946043891248	1.02695772778809	NA	NA	NA	NA	0.501451565920473	0.435052976078329	1.13624523783305	0.783057763526826	0.613537578703008	NA	NA	NA	NA	0.57930595429382	0.563599976154154	0.719463130006416	0.647769203112197	NA	NA	p.Lys219Asn	1	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.36	-2.976	0.616	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219P	219	K	P	missense	low	0.374185680369484	0.254402703181494	3	0.146879469164404	0.0863072107388905	0.662064150000078	NA	NA	NA	NA	0.634710633175852	0.126382584987237	0.361463822945363	NA	0.560086661399403	NA	NA	NA	NA	0.598790392765973	0.504294602163558	0.560086661399403	NA	NA	NA	p.Lys219Pro	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.36	-3.519	1.159	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219Q	219	K	Q	missense	possibly_wt-like	0.81722133552874	0.176924509681787	4	0.0884622548408934	0.643838502049385	0.990604169008096	NA	NA	NA	NA	0.957216530685656	0.852231093085489	0.899673473481231	0.559764244862586	0.644849315892541	NA	NA	NA	NA	0.645945505332489	0.643753126452593	0.670799117615271	0.59755016089258	NA	NA	p.Lys219Gln	1	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.36	-2.655	0.295	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219R	219	K	R	missense	wt-like	1.26366049293028	0.0837729269470746	4	0.0418864634735373	1.1815645330824	1.34575645277817	NA	NA	NA	NA	1.18019061746278	1.28629676497857	1.37064009661498	1.21751449266481	0.736315037541459	NA	NA	NA	NA	0.678547601116092	0.727150911763661	0.767679341875306	0.745479163319256	NA	NA	p.Lys219Arg	1	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.36	-2.322	-0.038	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219S	219	K	S	missense	wt-like	1.29231057460916	0.27686059698267	4	0.138430298491335	1.02099217519702	1.56362897402131	NA	NA	NA	NA	1.55396979487307	1.50613890136476	1.01766784496728	1.09146575723154	0.725165119471028	NA	NA	NA	NA	0.733199622433829	0.769389560152281	0.695071158582693	0.717130616508227	NA	NA	p.Lys219Ser	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.36	-2.315	-0.045	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219T	219	K	T	missense	wt-like	1.48617230552481	0.390134990613294	4	0.195067495306647	1.10384704016934	1.86849757088027	NA	NA	NA	NA	1.73961286780983	1.74856470974695	1.53687550378059	0.919636140761855	0.781109091401995	NA	NA	NA	NA	0.760343374126807	0.815967248346662	0.801874808677184	0.678485881919907	NA	NA	p.Lys219Thr	1	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.36	-2.564	0.204	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219V	219	K	V	missense	wt-like	1.17825291967997	0.196140616102912	4	0.0980703080514558	0.986038647946366	1.37046719141357	NA	NA	NA	NA	1.45401602389275	1.05606031480341	1.18098229882602	1.02195304119769	0.710041006414183	NA	NA	NA	NA	0.718584908847448	0.682915185960354	0.72866577046721	0.701497103980918	NA	NA	p.Lys219Val	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.36	-2.966	0.606	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219W	219	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys219Trp	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.36	-5.874	3.514	0.011264475	NA	NA	NA	NA	NA	NA	NA
K219X	219	K	X	nonsense	low	0.443933986025082	0.106796307872729	4	0.0533981539363647	0.339275527468882	0.548592444581283	NA	NA	NA	NA	0.296888652492343	0.44077627186816	0.544565639968072	0.493505379771753	0.573674023541562	NA	NA	NA	NA	0.549395843241216	0.564699602833846	0.597751634296097	0.582648444249278	NA	NA	p.Lys219Ter	1	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K219Y	219	K	Y	missense	possibly_wt-like	0.842229786345457	0.225977955408186	4	0.112988977704093	0.620775459395436	1.06368411329548	NA	NA	NA	NA	0.798227672192364	0.542201335811242	1.04638800797563	0.982102129402593	0.657616783720376	NA	NA	NA	NA	0.622698992394395	0.58418657509543	0.700979041851616	0.692534575046358	NA	NA	p.Lys219Tyr	0	40.8	12.3	23	0.883	29	165.7	-141.6	115.4	53.0434782608696	-1	0	1	17.04	0	0	0	0	5	22.7240401179234	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.36	-4.048	1.688	0.011264475	NA	NA	NA	NA	NA	NA	NA
V220A	220	V	A	missense	possibly_low	0.699411686656152	0.167099959953597	4	0.0835499799767984	0.535656734992584	0.86316663831972	NA	NA	NA	NA	0.451610992301114	0.758537152785982	0.770651529137546	0.816847072399966	0.635005098623836	NA	NA	NA	NA	0.572018528303946	0.62575154829515	0.644258648952522	0.65536846859479	NA	NA	p.Val220Ala	1	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.191	-2.549	0.358	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220C	220	V	C	missense	low	0.527428214620503	0.0772876031650683	4	0.0386438015825341	0.451687755293025	0.603168673947982	NA	NA	NA	NA	0.528501195748105	0.523919616611005	0.623260221641034	0.43403182448187	0.581967542746743	NA	NA	NA	NA	0.583261008602139	0.580674076891347	0.613939509075413	0.569272753804163	NA	NA	p.Val220Cys	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.191	-3.589	1.398	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220D	220	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val220Asp	1	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.191	-3.123	0.932	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220E	220	V	E	missense	wt-like	1.07528571411256	0.201145650787761	4	0.100572825393881	0.878166598517121	1.272404829708	NA	NA	NA	NA	0.961342612478088	1.07696082373172	1.35735203524724	0.905487384993202	0.681117321295931	NA	NA	NA	NA	0.646548799265664	0.686930836746314	0.764945920222786	0.675303805845547	NA	NA	p.Val220Glu	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.191	-2.79	0.599	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220F	220	V	F	missense	possibly_low	0.676221500707529	0.291834022068085	4	0.145917011034043	0.390229414349071	0.962213587065986	NA	NA	NA	NA	0.960797267392434	0.379184213583349	0.89006864712667	0.47483587472766	0.61245935338292	NA	NA	NA	NA	0.646469061781481	0.552865814570192	0.668823356095236	0.578449644984358	NA	NA	p.Val220Phe	1	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.191	-3.397	1.206	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220G	220	V	G	missense	wt-like	0.894819964923624	0.0849268143846184	4	0.0424634071923092	0.811593216165839	0.978046713681409	NA	NA	NA	NA	0.981373304556482	0.789583768179671	0.942220749246897	0.866102037711445	0.657961782273709	NA	NA	NA	NA	0.649477581489602	0.631716587995124	0.679551308142923	0.666445983057816	NA	NA	p.Val220Gly	1	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.191	-3.272	1.081	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220H	220	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val220His	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.191	-3.707	1.516	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220I	220	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val220Ile	1	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.191	-2.684	0.493	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220K	220	V	K	missense	wt-like	1.1014309150124	0.26378090376959	4	0.131890451884795	0.842930379413486	1.35993145061131	NA	NA	NA	NA	1.36037086087421	1.26353527775494	0.775206079899963	1.00661144152047	0.701469681108525	NA	NA	NA	NA	0.704892606667718	0.722777708011893	0.645195543156044	0.698046755549332	NA	NA	p.Val220Lys	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.191	-3.068	0.877	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220L	220	V	L	missense	possibly_low	0.682114949640817	0.145445564935463	2	0.102845545259374	0.48054138496206	0.883688514319573	NA	NA	NA	NA	0.78496049490019	0.579269404381443	NA	NA	0.606033831311416	NA	NA	NA	NA	0.620759135655393	0.591308526967439	NA	NA	NA	NA	p.Val220Leu	1	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.191	-2.631	0.44	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220M	220	V	M	missense	wt-like	1.19424634462169	0.0935367688152727	4	0.0467683844076363	1.1025819955676	1.28591069367578	NA	NA	NA	NA	1.11487749637162	1.11269619112896	1.28793606077897	1.26147563020723	0.722231718237553	NA	NA	NA	NA	0.668997860782953	0.6937967344461	0.750666702029006	0.755366088096436	NA	NA	p.Val220Met	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.191	-3.692	1.501	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220N	220	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val220Asn	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.191	-3.308	1.117	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220P	220	V	P	missense	possibly_low	0.569980109460604	0.188805880721506	4	0.0944029403607532	0.384953746318845	0.755006472602363	NA	NA	NA	NA	0.762459890459645	0.316365905222043	0.643591729820987	0.557502912339741	0.607255399865528	NA	NA	NA	NA	0.617469215863535	0.540796424766865	0.618121803478596	0.59704158386752	NA	NA	p.Val220Pro	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.191	-3.624	1.433	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220Q	220	V	Q	missense	wt-like	1.18950923105714	0.289341971777783	4	0.144670985888891	0.905959309107015	1.47305915300727	NA	NA	NA	NA	1.44934292226531	0.932671391704926	0.945449334158227	1.43057327610012	0.699058538499719	NA	NA	NA	NA	0.717901632557066	0.659208259601833	0.680215444442372	0.793396398466089	NA	NA	p.Val220Gln	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.191	-2.911	0.72	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220R	220	V	R	missense	possibly_low	0.712560192026768	0.135572120379058	4	0.0677860601895291	0.579701955401427	0.84541842865211	NA	NA	NA	NA	0.619229409952274	0.628970942086063	0.910087281479578	0.691953134589158	0.614068703251556	NA	NA	NA	NA	0.59652680990001	0.600857769028076	0.672941290764544	0.627279637475037	NA	NA	p.Val220Arg	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.191	-2.424	0.233	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220S	220	V	S	missense	possibly_low	0.67836429784129	0.180158088679698	4	0.090079044339849	0.5018126151734	0.854915980509181	NA	NA	NA	NA	0.478234058045755	0.581116041865698	0.784365785738168	0.869741305715542	0.619371532867826	NA	NA	NA	NA	0.575911212660256	0.591663324608514	0.647079741127138	0.667264459808236	NA	NA	p.Val220Ser	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.191	-2.995	0.804	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220T	220	V	T	missense	wt-like	1.42073571036267	0.348736670381336	4	0.174368335190668	1.07898005334475	1.76249136738059	NA	NA	NA	NA	1.81309085752112	1.33359336988539	0.988184653457047	1.54807396058712	0.753662514229744	NA	NA	NA	NA	0.771086938516639	0.73623808994285	0.689006316479005	0.819822475991248	NA	NA	p.Val220Thr	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.191	-3.184	0.993	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220V	220	V	V	synonymous	wt-like	1.34368509536986	0.235694340124088	4	0.117847170062044	1.11270888636829	1.57466130437144	NA	NA	NA	NA	1.49368714043242	1.58891015659662	1.20046496531135	1.09167811913906	0.728529432123842	NA	NA	NA	NA	0.724385410421255	0.785292544011035	0.73267345382643	0.717178377014951	NA	NA	p.Val220=	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220W	220	V	W	missense	wt-like	1.18681401638301	0.12030902282101	4	0.0601545114105049	1.06891334051082	1.3047146922552	NA	NA	NA	NA	1.34909857613303	1.20693002283071	1.0907728866045	1.1004545799638	0.711005639740864	NA	NA	NA	NA	0.703244432603441	0.711902042868734	0.710109236612994	0.71915221601992	NA	NA	p.Val220Trp	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.191	-4.541	2.35	0.013865256	NA	NA	NA	NA	NA	NA	NA
V220X	220	V	X	nonsense	low	0.256172644339988	0.0596691888289691	4	0.0298345944144845	0.197697913794239	0.314647374885738	NA	NA	NA	NA	0.24310767958964	0.177747634311611	0.311267846757274	0.292567416701427	0.539494736172326	NA	NA	NA	NA	0.541532272836006	0.51416345757745	0.549761094382157	0.537457199508645	NA	NA	p.Val220Ter	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V220Y	220	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val220Tyr	0	39.5	9.6	25.4	0.911	44.9	-95.2	-134.4	151.3	26.0606060606061	-6.2	0	1	18.16	0	0	0	0	5	22.6157330435954	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.191	-3.4	1.209	0.013865256	NA	NA	NA	NA	NA	NA	NA
D221A	221	D	A	missense	wt-like	0.872882054343213	0.0796226474959999	4	0.039811323748	0.794853293620269	0.950910815066157	NA	NA	NA	NA	0.834497411030807	0.885385157020773	0.978166374763538	0.793479274557736	0.650118045105081	NA	NA	NA	NA	0.62800216244769	0.650123073871391	0.686945505714818	0.650113016338771	NA	NA	p.Asp221Ala	1	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.397	-2.898	1.501	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221C	221	D	C	missense	wt-like	1.29584527153596	0.230276254753909	4	0.115138127376955	1.07017868862974	1.52151185444217	NA	NA	NA	NA	1.36206794897389	1.08074445764789	1.59090313725081	1.14966554227124	0.717680290043742	NA	NA	NA	NA	0.70514074594515	0.687657792848741	0.812988567040793	0.730219834142333	NA	NA	p.Asp221Cys	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.397	-5.498	4.101	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221E	221	D	E	missense	wt-like	1.02475227459848	0.0836792338774919	4	0.041839616938746	0.942748132271588	1.10675641692538	NA	NA	NA	NA	1.00121331901941	1.14881865771888	0.976387356841666	0.972589764813981	0.688487391449275	NA	NA	NA	NA	0.652378483837572	0.700737006180637	0.686579552700809	0.690395230197741	NA	NA	p.Asp221Glu	1	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.397	-2.046	0.649	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221F	221	D	F	missense	low	0.352235199291924	0.303752752904748	4	0.151876376452374	0.0545629713428232	0.649907427241024	NA	NA	NA	NA	0.0489827465809827	0.385876704860372	0.758479774974481	0.215601570751859	0.537149560750624	NA	NA	NA	NA	0.51314834826696	0.554151654448483	0.641754857356613	0.520147467052766	NA	NA	p.Asp221Phe	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.397	-4.634	3.237	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221G	221	D	G	missense	wt-like	0.87091592102608	0.0798729825611303	4	0.0399364912805651	0.792641836447274	0.949190005604886	NA	NA	NA	NA	0.914068459679983	0.81971245846861	0.960447918317656	0.78943484763807	0.644420020275825	NA	NA	NA	NA	0.639636621801952	0.637505265163402	0.683300729313049	0.649203418749697	NA	NA	p.Asp221Gly	1	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.397	-2.771	1.374	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221H	221	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp221His	1	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.397	-3.502	2.105	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221I	221	D	I	missense	low	0.251324798963755	0.167063175136962	3	0.0964539691369983	0.0622784932893005	0.44037110463821	NA	NA	NA	NA	0.0921669361663295	0.425305454494816	NA	0.23650200623012	0.524848005868088	NA	NA	NA	NA	0.519462512865854	0.561727168040139	NA	0.524848005868088	NA	NA	p.Asp221Ile	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.397	-3.195	1.798	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221K	221	D	K	missense	wt-like	0.810216054268134	0.0893214592284823	4	0.0446607296142412	0.722682632700939	0.897749475835328	NA	NA	NA	NA	0.91912256799077	0.701398395018752	0.799376869210593	0.820966384852419	0.645271602025701	NA	NA	NA	NA	0.640375606881477	0.614773380331694	0.650167597169925	0.656294908050817	NA	NA	p.Asp221Lys	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.397	-3.429	2.032	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221L	221	D	L	missense	wt-like	0.888928211132633	0.0717864281940412	4	0.0358932140970206	0.818578804213088	0.959277618052179	NA	NA	NA	NA	0.945336776422326	0.919158416731264	0.907297333287043	0.7839203180899	0.652287590674431	NA	NA	NA	NA	0.644208510276351	0.656611988441176	0.672367384263976	0.647963192907686	NA	NA	p.Asp221Leu	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.397	-2.91	1.513	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221M	221	D	M	missense	possibly_low	0.582740166645463	0.208517266223477	4	0.104258633111738	0.378397000669081	0.787083332621845	NA	NA	NA	NA	0.429969696497831	0.643785017334708	0.851275680093168	0.405930272656146	0.586279137459014	NA	NA	NA	NA	0.568854252092041	0.603704022825987	0.660843445924721	0.56295267328407	NA	NA	p.Asp221Met	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.397	-5.12	3.723	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221N	221	D	N	missense	possibly_wt-like	0.924282711390049	0.595303837712291	4	0.297651918856145	0.340895670502766	1.50766975227733	NA	NA	NA	NA	0.094063668885851	0.985430606602831	1.11591670499903	1.50171986507249	0.692313213048051	NA	NA	NA	NA	0.519739843127372	0.669344978449114	0.715281447646988	0.809397371430995	NA	NA	p.Asp221Asn	1	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.397	-2.561	1.164	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221P	221	D	P	missense	wt-like	0.936892289787375	0.0999990449926229	4	0.0499995224963114	0.838895026450405	1.03488955312435	NA	NA	NA	NA	0.874095704933579	0.906881777886933	1.08539580510991	0.881195871219083	0.662046932591368	NA	NA	NA	NA	0.633792016279341	0.654253256670898	0.709003143663998	0.669840608511838	NA	NA	p.Asp221Pro	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.397	-2.966	1.569	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221Q	221	D	Q	missense	possibly_wt-like	0.780716350027475	0.206583241252898	4	0.103291620626449	0.578268493694861	0.983164206360089	NA	NA	NA	NA	0.719314655462854	0.515506028594702	0.926912134286601	0.961132581765742	0.643781497681275	NA	NA	NA	NA	0.61116074699927	0.579057559731584	0.676402248363281	0.687818492804469	NA	NA	p.Asp221Gln	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.397	-3.279	1.882	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221R	221	D	R	missense	wt-like	0.839946126363259	0.113313872715615	4	0.0566569363578075	0.728900571627579	0.95099168109894	NA	NA	NA	NA	0.880133522069596	0.672538362498652	0.883716904749902	0.923395716134888	0.651095802267797	NA	NA	NA	NA	0.634674834078654	0.609228452566075	0.66751677045694	0.679331415975331	NA	NA	p.Asp221Arg	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.397	-4.229	2.832	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221S	221	D	S	missense	wt-like	0.884177293079616	0.0531653559779336	4	0.0265826779889668	0.832076201608615	0.936278384550616	NA	NA	NA	NA	0.944364234029207	0.825455818693758	0.909976729118575	0.856912390476922	0.654222764036149	NA	NA	NA	NA	0.644066310253414	0.638608746857616	0.672918549582896	0.664379217818884	NA	NA	p.Asp221Ser	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.397	-3.048	1.651	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221T	221	D	T	missense	possibly_low	0.716299842505884	0.205471337378597	4	0.102735668689299	0.51494163194722	0.917658053064549	NA	NA	NA	NA	0.75703750235391	0.543542730319118	0.990199283203816	0.574419854146693	0.608761305962376	NA	NA	NA	NA	0.616676382853411	0.584444299533066	0.689420736040988	0.600846229071341	NA	NA	p.Asp221Thr	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.397	-3.446	2.049	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221V	221	D	V	missense	wt-like	1.19508535257281	0.14421659262734	4	0.0721082963136701	1.05375568881148	1.33641501633415	NA	NA	NA	NA	1.3076473556861	1.08029729480862	1.33137658886206	1.06102017093448	0.703733506395518	NA	NA	NA	NA	0.697183653618353	0.687571878682097	0.759602639091086	0.710283359172684	NA	NA	p.Asp221Val	1	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.397	-3.959	2.562	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221W	221	D	W	missense	wt-like	1.11641831928061	0.177428436110658	4	0.0887142180553288	0.94254164697553	1.29029499158569	NA	NA	NA	NA	1.35334413231859	1.11397146633833	1.07270614873478	0.925651529730734	0.698953475360849	NA	NA	NA	NA	0.703865195452689	0.694041755269009	0.706392816955016	0.679838751785556	NA	NA	p.Asp221Trp	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.397	-5.841	4.444	0.012356957	NA	NA	NA	NA	NA	NA	NA
D221X	221	D	X	nonsense	low	0.291108628185934	0.404512748284302	4	0.202256374142151	-0.10530658077634	0.687523837148208	NA	NA	NA	NA	-0.0676601105195462	-0.0493489523082263	0.670776702979116	0.610666872592392	0.552545840767747	NA	NA	NA	NA	0.496093444467912	0.470530999168108	0.623713890405135	0.608998237067583	NA	NA	p.Asp221Ter	0	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D221Y	221	D	Y	missense	possibly_wt-like	0.762885812284465	0.333821376145093	3	0.192731861378621	0.385138305309002	1.14063331925993	NA	NA	NA	NA	0.378121394363831	0.935169061121161	NA	0.975366981368402	0.65968814112954	NA	NA	NA	NA	0.56127326662049	0.65968814112954	NA	0.691019830303618	NA	NA	p.Asp221Tyr	1	39	5.8	25.6	0.527	40.7	171.7	-64.6	124.3	60.9625668449198	-0.8	0	1	18.24	1	2	0	0	5	22.7866420041753	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.397	-3.862	2.465	0.012356957	NA	NA	NA	NA	NA	NA	NA
A222A	222	A	A	synonymous	wt-like	1.33791104482133	0.147032178097873	4	0.0735160890489365	1.19382215800118	1.48199993164149	NA	NA	NA	NA	1.32098976050256	1.37631557741805	1.5044592698325	1.14987957153222	0.737357175456741	NA	NA	NA	NA	0.699134509729469	0.74444638127417	0.795206624860547	0.730267969639313	NA	NA	p.Ala222=	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222C	222	A	C	missense	wt-like	1.1936483965671	0.286308132526262	4	0.143154066263131	0.9130715824509	1.47422521068329	NA	NA	NA	NA	1.34273502871102	1.48836697599409	1.11021896941162	0.833272612151646	0.708211691381221	NA	NA	NA	NA	0.702313988238473	0.765975009514902	0.714109394523968	0.659062596750431	NA	NA	p.Ala222Cys	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.041	-5.361	3.32	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222D	222	A	D	missense	possibly_low	0.625709195711304	0.140622195884038	4	0.0703110979420188	0.487901976031479	0.763516415391129	NA	NA	NA	NA	0.465491852660319	0.566824999107591	0.679653680092513	0.790866250984791	0.607228745793448	NA	NA	NA	NA	0.574048114546593	0.588917561944044	0.625539929642852	0.64952534347699	NA	NA	p.Ala222Asp	1	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.041	-2.766	0.725	0.020323247	NA	NA	NA	NA	4.06e-06	NA	NA
A222E	222	A	E	missense	possibly_wt-like	0.746507128781112	0.208417273029338	4	0.104208636514669	0.542261954334335	0.950752303227889	NA	NA	NA	NA	0.990138297580287	0.596641372227128	0.848119222948379	0.551129622368655	0.623183687055697	NA	NA	NA	NA	0.650759152573646	0.594646233076532	0.660194146672856	0.595608221537747	NA	NA	p.Ala222Glu	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.041	-2.639	0.598	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222F	222	A	F	missense	low	0.357725591285941	0.272812727878459	4	0.136406363939229	0.0903740307029889	0.625077151868894	NA	NA	NA	NA	0.287346967073332	0.407792221671625	0.696221539093755	0.0395416373050543	0.55318151436813	NA	NA	NA	NA	0.548000708288702	0.558362320447558	0.628948022311646	0.480551327926834	NA	NA	p.Ala222Phe	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.041	-3.951	1.91	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222G	222	A	G	missense	wt-like	0.9820115633855	0.0649942409161641	4	0.0324971204580821	0.918318377686399	1.0457047490846	NA	NA	NA	NA	0.981693866144202	1.02205620024623	1.03384176595417	0.890454421197403	0.674152393465409	NA	NA	NA	NA	0.649524452315438	0.676381916851178	0.698398216202927	0.67192287007964	NA	NA	p.Ala222Gly	1	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.041	-2.791	0.75	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222H	222	A	H	missense	wt-like	1.41270468745365	0.115652136631023	4	0.0578260683155114	1.2993676761877	1.52604169871961	NA	NA	NA	NA	1.56640081222403	1.30438037291062	1.43326397657968	1.34677358810028	0.754783472555331	NA	NA	NA	NA	0.735017220273209	0.7306253465085	0.780561391763778	0.774549724837453	NA	NA	p.Ala222His	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.041	-3.95	1.909	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222I	222	A	I	missense	possibly_low	0.650285992483801	0.236984866842556	4	0.118492433421278	0.418045090537587	0.882526894430016	NA	NA	NA	NA	0.313329598956507	0.788599551781727	0.659925355325537	0.839289463871433	0.626504600965794	NA	NA	NA	NA	0.551799751781196	0.631527488803065	0.621481713128522	0.66041579559092	NA	NA	p.Ala222Ile	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.041	-2.448	0.407	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222K	222	A	K	missense	wt-like	0.95674945602819	0.121626572480978	4	0.060813286240489	0.837557605215307	1.07594130684107	NA	NA	NA	NA	1.01709118572291	0.84783675146265	1.09871331454794	0.863356572379255	0.660264292835692	NA	NA	NA	NA	0.654700061822661	0.642908834026411	0.711742622934009	0.665828523848724	NA	NA	p.Ala222Lys	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.041	-3.075	1.034	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222L	222	A	L	missense	wt-like	0.98512917210217	0.0354949492750813	4	0.0177474746375407	0.950344760996052	1.01991358320829	NA	NA	NA	NA	1.00688924246713	0.959072762263018	0.951097182568686	1.02345750110985	0.672829017964535	NA	NA	NA	NA	0.653208387449143	0.664280800409124	0.681377235519946	0.701835459237705	NA	NA	p.Ala222Leu	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.041	-3.133	1.092	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222M	222	A	M	missense	wt-like	1.11738790483378	0.171156484606103	4	0.0855782423030515	0.949657632059552	1.285118177608	NA	NA	NA	NA	0.951259303176723	1.23892377616524	1.28888160670267	0.990486933290469	0.706234693820279	NA	NA	NA	NA	0.645074470923701	0.718049057812928	0.750861205623606	0.694420329827631	NA	NA	p.Ala222Met	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.041	-3.917	1.876	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222N	222	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala222Asn	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.041	-3.425	1.384	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222P	222	A	P	missense	possibly_wt-like	0.946244329836772	0.237598948972812	4	0.118799474486406	0.713401638461131	1.17908702121241	NA	NA	NA	NA	1.16695608666883	0.62004217453629	1.06484597844333	0.933133079698629	0.679066940600921	NA	NA	NA	NA	0.676612517775997	0.59914226953704	0.704775940040277	0.681521363425846	NA	NA	p.Ala222Pro	1	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.041	-3.465	1.424	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222Q	222	A	Q	missense	wt-like	1.03093727266387	0.168685735590295	4	0.0843428677951473	0.865628289432562	1.19624625589519	NA	NA	NA	NA	1.21952665125923	0.881265839045133	0.89606634846812	1.12689025188301	0.677178111176626	NA	NA	NA	NA	0.684299108657238	0.649331622212332	0.670057113696014	0.725097637688031	NA	NA	p.Ala222Gln	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.041	-3.672	1.631	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222R	222	A	R	missense	wt-like	0.917188866903519	0.0660027372739113	4	0.0330013686369557	0.852507372934556	0.981870360872482	NA	NA	NA	NA	0.847163464893979	0.885797689222935	0.999814704446937	0.935979609050224	0.666181943238135	NA	NA	NA	NA	0.629854126087125	0.650202334394067	0.691398676983363	0.682161552082204	NA	NA	p.Ala222Arg	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.041	-3.061	1.02	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222S	222	A	S	missense	wt-like	0.991169417661588	0.165155154453911	4	0.0825775772269553	0.82932034036618	1.153018494957	NA	NA	NA	NA	1.12635243654257	1.08955515715982	0.98970479036275	0.75906528658122	0.679997341205197	NA	NA	NA	NA	0.670675666056076	0.689350607724266	0.689319016354318	0.642373259602989	NA	NA	p.Ala222Ser	1	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.041	-2.716	0.675	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222T	222	A	T	missense	wt-like	1.11660991540321	0.0328484652588121	3	0.0189650702596413	1.07943906073004	1.15378077007638	NA	NA	NA	NA	1.11029702720081	1.08737604842582	1.15215667058299	NA	0.688931931809227	NA	NA	NA	NA	0.668328128722161	0.688931931809227	0.722736192464336	NA	NA	NA	p.Ala222Thr	1	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.041	-2.727	0.686	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222V	222	A	V	missense	wt-like	1.25209495606419	0.114265572627367	4	0.0571327863136834	1.14011675255294	1.36407315957543	NA	NA	NA	NA	1.3370597269644	1.36205191090253	1.17540762767612	1.13386055871369	0.727092151157483	NA	NA	NA	NA	0.701484175528759	0.74170587845435	0.727519032323465	0.726665269991501	NA	NA	p.Ala222Val	1	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.041	-2.093	0.052	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222W	222	A	W	missense	low	0.522472024220487	0.0944658003415462	4	0.0472329001707731	0.429897241000396	0.615046807440578	NA	NA	NA	NA	0.504942133460015	0.395951938114647	0.600881960837106	0.588112064470179	0.591870977041521	NA	NA	NA	NA	0.579816326682415	0.556087426370355	0.609336187271399	0.603925627400627	NA	NA	p.Ala222Trp	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.041	-5.841	3.8	0.020323247	NA	NA	NA	NA	NA	NA	NA
A222X	222	A	X	nonsense	low	0.567167816318379	0.0529077376972686	4	0.0264538688486343	0.51531918612331	0.619016446513448	NA	NA	NA	NA	0.626305336008707	0.595286121883696	0.535848666041387	0.511231141339725	0.595172177509576	NA	NA	NA	NA	0.597561414514313	0.594385846493342	0.59595850852581	0.586634994212223	NA	NA	p.Ala222Ter	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A222Y	222	A	Y	missense	wt-like	1.57025015440442	0.225277741570708	2	0.159295418715038	1.25803687082071	1.88246343798812	NA	NA	NA	NA	1.72954557311945	1.41095473568938	NA	NA	0.7549865248915	NA	NA	NA	NA	0.758871387356858	0.751101662426142	NA	NA	NA	NA	p.Ala222Tyr	0	35.3	5.3	24.7	0.296	26.4	133.3	-116.4	4.2	16.5289256198347	-3.7	0	0	16.75	0	0	0	0	6	19.4263883137694	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.041	-3.98	1.939	0.020323247	NA	NA	NA	NA	NA	NA	NA
F223A	223	F	A	missense	wt-like	1.0931593681148	0.12693490296335	4	0.0634674514816748	0.96876544902017	1.21755328720942	NA	NA	NA	NA	1.24551944935917	0.967097791382512	1.14666777714437	1.01335245457313	0.693831228971878	NA	NA	NA	NA	0.688099638600366	0.665822663078668	0.721607099231074	0.699562819343389	NA	NA	p.Phe223Ala	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.268	-2.876	0.608	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223C	223	F	C	missense	wt-like	0.900800544168777	0.0519245689066193	4	0.0259622844533096	0.849915401683906	0.951685686653648	NA	NA	NA	NA	0.953512092000317	0.829504805738986	0.915298737107826	0.904886541827978	0.65970858773227	NA	NA	NA	NA	0.645403861832163	0.639386685713855	0.674013313632378	0.675168675330061	NA	NA	p.Phe223Cys	1	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.268	-3.956	1.688	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223D	223	F	D	missense	wt-like	1.151810029141	0.278597347206914	4	0.139298673603457	0.878789645784024	1.42483041249798	NA	NA	NA	NA	1.33997849247406	0.796922510693479	1.06546495658366	1.40487415681281	0.703407104511462	NA	NA	NA	NA	0.701910942038228	0.633126593236843	0.704903266984695	0.787616628573005	NA	NA	p.Phe223Asp	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.268	-3.227	0.959	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223E	223	F	E	missense	low	0.419393110131427	0.221615272595729	4	0.110807636297864	0.2022141337756	0.636572086487255	NA	NA	NA	NA	0.161333811362517	0.308763200660687	0.620177642113642	0.587297786388864	0.571539099549712	NA	NA	NA	NA	0.529575728813017	0.539335704042219	0.613305406824331	0.603742495057204	NA	NA	p.Phe223Glu	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.268	-3.054	0.786	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223G	223	F	G	missense	wt-like	0.885461605880478	0.0785421166492539	4	0.0392710583246269	0.808491745929437	0.962431465831519	NA	NA	NA	NA	0.89396924290665	0.773270214918907	0.952668113571132	0.921938852125223	0.657850792682804	NA	NA	NA	NA	0.63669782025828	0.628582236903575	0.681700383998709	0.679003765107329	NA	NA	p.Phe223Gly	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.268	-3.123	0.855	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223H	223	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe223His	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.268	-3.683	1.415	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223I	223	F	I	missense	wt-like	1.43728220902496	0.290491432297988	4	0.145245716148994	1.15260583646421	1.72195858158572	NA	NA	NA	NA	1.68911348000701	1.07927775282172	1.65760107181657	1.32313653145455	0.761096667839029	NA	NA	NA	NA	0.752959619799307	0.687375992323777	0.826708670634159	0.769233715878751	NA	NA	p.Phe223Ile	1	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.268	-2.536	0.268	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223K	223	F	K	missense	low	0.414571420835391	0.035033191057968	4	0.017516595528984	0.380239524466827	0.448903317203955	NA	NA	NA	NA	0.414467997436594	0.367433083635305	0.425076510566159	0.451308091703507	0.569872943590796	NA	NA	NA	NA	0.566587675357014	0.550608049729458	0.573172114040356	0.573158211824578	NA	NA	p.Phe223Lys	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.268	-3.062	0.794	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223L	223	F	L	missense	wt-like	1.20607991158837	0.183775944727355	4	0.0918879723636775	1.02598279514315	1.38617702803359	NA	NA	NA	NA	1.41324409233076	1.30347387435864	1.08944056783743	1.01816111182665	0.711229311892395	NA	NA	NA	NA	0.712623451902923	0.730451179380071	0.709835171881866	0.700644293463546	NA	NA	p.Phe223Leu	1	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.268	-1.868	-0.4	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223M	223	F	M	missense	possibly_wt-like	0.854981066208559	0.196925128768537	4	0.0984625643842687	0.661997986189936	1.04796414622718	NA	NA	NA	NA	0.826092480414163	1.0635235880788	0.932301064685948	0.598007131655323	0.652142008241612	NA	NA	NA	NA	0.626773237791112	0.684349117511828	0.677510778692111	0.606151042628571	NA	NA	p.Phe223Met	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.268	-3.307	1.039	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223N	223	F	N	missense	wt-like	1.04469386414911	0.309770434095128	4	0.154885217047564	0.741124416998211	1.3482633113	NA	NA	NA	NA	0.869887627478484	0.701446951164171	1.35523727569944	1.25220360225433	0.693228764342386	NA	NA	NA	NA	0.63317673337253	0.614782709507561	0.764510903452631	0.753280795312241	NA	NA	p.Phe223Asn	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.268	-3.422	1.154	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223P	223	F	P	missense	possibly_low	0.570449904874145	0.356580513990896	4	0.178290256995448	0.221007422368676	0.919892387379614	NA	NA	NA	NA	0.414333796188301	0.259688200628511	1.07913094706163	0.528646675618139	0.578559913378622	NA	NA	NA	NA	0.566568053157796	0.529906839743933	0.70771443057296	0.590551773599447	NA	NA	p.Phe223Pro	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.268	-3.315	1.047	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223Q	223	F	Q	missense	low	0.244094300781233	0.174592965469911	4	0.0872964827349557	0.0729963386436971	0.415192262918769	NA	NA	NA	NA	0.00228201841653741	0.23475118518493	0.395634666234865	0.343709333288599	0.537037370054314	NA	NA	NA	NA	0.506320013930948	0.525115648007456	0.56711577726119	0.548959092101172	NA	NA	p.Phe223Gln	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.268	-3.206	0.938	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223R	223	F	R	missense	possibly_wt-like	0.722428227349801	0.0669500733997195	4	0.0334750366998598	0.65681836103692	0.788038093662683	NA	NA	NA	NA	0.746643166155959	0.626967950288498	0.78264723883891	0.733454554115838	0.625884972917314	NA	NA	NA	NA	0.615156577797897	0.600472930763431	0.646726227309335	0.636613368036731	NA	NA	p.Phe223Arg	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.268	-3.609	1.341	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223S	223	F	S	missense	wt-like	1.16077389279072	0.25080895851527	4	0.125404479257635	0.914985629945751	1.40656215563568	NA	NA	NA	NA	1.47800510882265	0.977933808500269	1.24460609261346	0.942550561226492	0.702865917672676	NA	NA	NA	NA	0.722092466411422	0.667904605714842	0.741753507702998	0.68363936893393	NA	NA	p.Phe223Ser	1	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.268	-3.016	0.748	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223T	223	F	T	missense	wt-like	1.35478426727762	0.401830994697014	4	0.200915497348507	0.960997128538594	1.74857140601665	NA	NA	NA	NA	1.94773572038321	1.17654017550483	1.06068104732186	1.23418012590059	0.727645239001606	NA	NA	NA	NA	0.790774000718569	0.706063189149049	0.703919192573989	0.749227288854163	NA	NA	p.Phe223Thr	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.268	-3.15	0.882	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223V	223	F	V	missense	wt-like	0.949438128438498	0.0715681434089656	4	0.0357840717044828	0.879302636677513	1.01957362019948	NA	NA	NA	NA	0.963284861747281	0.849911009904989	1.02054538580812	0.964011256293598	0.667649347837818	NA	NA	NA	NA	0.64683278471718	0.643307364874288	0.695663083335498	0.688465910958456	NA	NA	p.Phe223Val	1	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.268	-3.023	0.755	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223W	223	F	W	missense	wt-like	0.914313921949735	0.124247753733884	4	0.062123876866942	0.792553360710528	1.03607448318894	NA	NA	NA	NA	1.05615080564572	0.964651023766986	0.869195385976598	0.767258472409637	0.66247038697053	NA	NA	NA	NA	0.660411153584042	0.665352561401621	0.664529620357018	0.644215919199612	NA	NA	p.Phe223Trp	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.268	-5.592	3.324	0.019156233	NA	NA	NA	NA	NA	NA	NA
F223X	223	F	X	nonsense	possibly_low	0.543850775381329	0.301870028830378	4	0.150935014415189	0.248023583121525	0.839677967641134	NA	NA	NA	NA	0.43070424642062	0.322596646506805	0.990075401070715	0.432026807527178	0.568891738319671	NA	NA	NA	NA	0.568961654110306	0.54199354782368	0.68939525285758	0.568821822529036	NA	NA	p.Phe223Ter	0	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F223Y	223	F	Y	missense	possibly_wt-like	0.855457446187822	0.16639086485482	4	0.0831954324274098	0.692397394951863	1.01851749742378	NA	NA	NA	NA	1.06585041641022	0.845456921188515	0.851733969082183	0.65878847807037	0.651694655715695	NA	NA	NA	NA	0.661829379548228	0.642451593136078	0.660937718295311	0.619820857229738	NA	NA	p.Phe223Tyr	1	35.3	1.5	24.4	0.44	28.3	174.2	-70.2	123.1	24.5614035087719	-1.4	0	0	19.2	0	0	0	0	5	20.6423078169149	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.268	-3.443	1.175	0.019156233	NA	NA	NA	NA	NA	NA	NA
E224A	224	E	A	missense	wt-like	1.35799564771788	0.123309487196696	4	0.0616547435983481	1.23715457078907	1.4788367246467	NA	NA	NA	NA	1.42731236841782	1.43033031372521	1.40018769532803	1.17415221340048	0.745275624133113	NA	NA	NA	NA	0.714680441085522	0.754824325612712	0.773757432867442	0.735726922653515	NA	NA	p.Glu224Ala	1	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.98	-2.489	0.509	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224C	224	E	C	missense	wt-like	1.23164980181113	0.21873518901133	4	0.109367594505665	1.01729325550424	1.44600634811801	NA	NA	NA	NA	1.41922794867044	1.38790758920343	1.17113564205788	0.948328027312749	0.720069321521474	NA	NA	NA	NA	0.713498379838996	0.746673574468196	0.726640263203951	0.684938729591793	NA	NA	p.Glu224Cys	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.98	-5.534	3.554	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224D	224	E	D	missense	wt-like	0.769779757666133	0.0166496658905047	2	0.0117730916556663	0.746704922034338	0.792854593297928	NA	NA	NA	NA	0.7815528493218	0.758006666010467	NA	NA	0.622955256318006	NA	NA	NA	NA	0.620260887678917	0.625649624957094	NA	NA	NA	NA	p.Glu224Asp	1	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.98	-2.4	0.42	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224E	224	E	E	synonymous	wt-like	0.907054553708119	0.154234523513263	4	0.0771172617566315	0.755907498078773	1.05820160933746	NA	NA	NA	NA	0.957629330605058	0.724544883354338	1.08876712742583	0.857276873447249	0.655233526669202	NA	NA	NA	NA	0.646005862761042	0.619220555010349	0.709696641771882	0.664461190577362	NA	NA	p.Glu224=	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224F	224	E	F	missense	possibly_wt-like	1.02199577749468	0.550504070981081	2	0.389265161661523	0.259050080201931	1.78494147478742	NA	NA	NA	NA	1.4112609391562	0.632730615833154	NA	NA	0.656956803659944	NA	NA	NA	NA	0.712333485697948	0.60158012162194	NA	NA	NA	NA	p.Glu224Phe	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.98	-4.72	2.74	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224G	224	E	G	missense	wt-like	0.92330010247188	0.119250486532568	4	0.0596252432662841	0.806436773100524	1.04016343184324	NA	NA	NA	NA	0.996080078755393	0.995586569370096	0.954732358087655	0.746801403674377	0.66146209478615	NA	NA	NA	NA	0.651627928500911	0.67129626107139	0.682125009570597	0.639615094219777	NA	NA	p.Glu224Gly	1	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.98	-2.569	0.589	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224H	224	E	H	missense	possibly_wt-like	0.732045394745929	0.231893876648234	4	0.115946938324117	0.504793571512972	0.959297217978885	NA	NA	NA	NA	0.850407291589245	0.872332892362937	0.385713284230525	0.819728110801007	0.638971870553651	NA	NA	NA	NA	0.630328421329918	0.647615319777385	0.565074898637659	0.656016418387349	NA	NA	p.Glu224His	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.98	-3.386	1.406	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224I	224	E	I	missense	wt-like	0.933395227570272	0.140544017395217	4	0.0702720086976084	0.795664621401674	1.07112583373887	NA	NA	NA	NA	1.04216980761346	0.767221738305852	0.866792511982663	1.05739685237911	0.661201131360948	NA	NA	NA	NA	0.658366925738617	0.627420132672124	0.664035336983278	0.709468469476845	NA	NA	p.Glu224Ile	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.98	-4.397	2.417	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224K	224	E	K	missense	wt-like	0.963987990884149	0.154440243712892	4	0.0772201218564461	0.81263933316372	1.11533664860458	NA	NA	NA	NA	1.19257928619019	0.919007200594689	0.857661958897613	0.886703517854103	0.666618211128978	NA	NA	NA	NA	0.680359006962934	0.656582935024354	0.662157135881442	0.671079286376513	NA	NA	p.Glu224Lys	1	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.98	-2.918	0.938	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224L	224	E	L	missense	possibly_low	0.503264007012721	0.334371877790102	4	0.167185938895051	0.175585588056906	0.830942425968536	NA	NA	NA	NA	0.301177121345912	0.376014587408056	1.00270890080402	0.3331554184929	0.551139854693694	NA	NA	NA	NA	0.550022880554609	0.552256828832779	0.691994027860376	0.546585501072296	NA	NA	p.Glu224Leu	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.98	-3.326	1.346	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224M	224	E	M	missense	possibly_wt-like	0.8559196721739	0.355753762263096	4	0.177876881131548	0.507287391473753	1.20455195287405	NA	NA	NA	NA	1.2846931159891	0.900169214971208	0.416920948403328	0.821895409331965	0.654733703711401	NA	NA	NA	NA	0.69382740567018	0.652963560394086	0.571494473518732	0.656503847028717	NA	NA	p.Glu224Met	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.98	-4.259	2.279	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224N	224	E	N	missense	wt-like	1.12597368021718	0.12061668025351	4	0.0603083401267548	1.00777150560135	1.24417585483301	NA	NA	NA	NA	1.28522672763682	1.06996470256496	1.14441212993418	1.00429116073276	0.695715174262665	NA	NA	NA	NA	0.69390542755291	0.68558665993424	0.721143101153841	0.69752492097242	NA	NA	p.Glu224Asn	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.98	-2.686	0.706	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224P	224	E	P	missense	low	0.463003895127955	0.164103811846512	4	0.0820519059232562	0.302185114655504	0.623822675600406	NA	NA	NA	NA	0.421588176761577	0.251241357874297	0.556563227931385	0.622622817944562	0.583924174735966	NA	NA	NA	NA	0.567628750451007	0.528283933294087	0.600219599020925	0.611687146839831	NA	NA	p.Glu224Pro	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.98	-2.968	0.988	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224Q	224	E	Q	missense	possibly_low	0.464301970658782	0.515584773496332	4	0.257792386748166	-0.0409618228562437	0.969565764173808	NA	NA	NA	NA	-0.230438520708839	0.719954981946175	0.960487406648869	0.407204014748925	0.590788914554079	NA	NA	NA	NA	0.472292843253662	0.618338689345719	0.68330885226316	0.563239139762438	NA	NA	p.Glu224Gln	1	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.98	-3.06	1.08	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224R	224	E	R	missense	possibly_wt-like	0.723976335979528	0.0445553851715866	4	0.0222776925857933	0.680312860852718	0.767639811106338	NA	NA	NA	NA	0.715320792061295	0.668099437449137	0.774629818409315	0.737855295998365	0.624089943364844	NA	NA	NA	NA	0.610576785342351	0.608375594249321	0.645077003243227	0.637603101387337	NA	NA	p.Glu224Arg	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.98	-2.975	0.995	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224S	224	E	S	missense	wt-like	0.924055455519407	0.141005832275339	4	0.0705029161376696	0.785872279084527	1.06223863195429	NA	NA	NA	NA	1.10707489323867	0.926946327901154	0.897666586154122	0.764534014783681	0.662982649253526	NA	NA	NA	NA	0.667857005276475	0.658108293230577	0.6703862907083	0.643603184654687	NA	NA	p.Glu224Ser	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.98	-2.546	0.566	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224T	224	E	T	missense	wt-like	0.980140985049817	0.171022634597238	4	0.0855113172986188	0.812541882873947	1.14774008722569	NA	NA	NA	NA	0.736516162455173	1.02997838510937	1.13675329240927	1.01731610022546	0.689179134491339	NA	NA	NA	NA	0.613675860691142	0.677904019876579	0.719567639410825	0.7004542491061	NA	NA	p.Glu224Thr	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.98	-2.759	0.779	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224V	224	E	V	missense	wt-like	0.980487813175643	0.117165840533896	4	0.0585829202669478	0.865667399343244	1.09530822700804	NA	NA	NA	NA	1.08811735868108	0.835134444022328	1.06164032677388	0.937059123225286	0.673744735452048	NA	NA	NA	NA	0.665085134489152	0.640468317815481	0.704116521225054	0.682404336414944	NA	NA	p.Glu224Val	1	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.98	-3.367	1.387	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224W	224	E	W	missense	possibly_wt-like	0.79984403354678	0.174586562831386	4	0.0872932814156929	0.628752345879703	0.970935721213858	NA	NA	NA	NA	0.902788768539945	0.538669660706319	0.8714281444769	0.886489560463957	0.651488137461774	NA	NA	NA	NA	0.637987364813069	0.583508028273462	0.664988910110479	0.67103116704339	NA	NA	p.Glu224Trp	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.98	-4.437	2.457	0.017078413	NA	NA	NA	NA	NA	NA	NA
E224X	224	E	X	nonsense	low	0.424598652609103	0.253916419498912	4	0.126958209749456	0.175765133958487	0.673432171259718	NA	NA	NA	NA	0.206111264697806	0.660577677438295	0.203903752108298	0.627801916192011	0.57152663879037	NA	NA	NA	NA	0.536122852040131	0.60693042554061	0.527675755302588	0.612851933686776	NA	NA	p.Glu224Ter	1	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E224Y	224	E	Y	missense	possibly_wt-like	0.735612521985596	0.163339739716029	4	0.0816698698580144	0.575542518441815	0.895682525529378	NA	NA	NA	NA	0.791608828994482	0.552888516454464	0.932179239701481	0.665773502791958	0.621561509817616	NA	NA	NA	NA	0.621731220026615	0.58623992152335	0.677485718674615	0.621391799608617	NA	NA	p.Glu224Tyr	0	32.4	-0.2	26.2	0.785	47.7	-98	-121.8	166.5	43.9252336448598	-3	0	0	25.26	0	0	0	0	5	20.5087236252171	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.98	-3.798	1.818	0.017078413	NA	NA	NA	NA	NA	NA	NA
E225A	225	E	A	missense	wt-like	0.968184774260048	0.0972987537132735	4	0.0486493768566367	0.872833747750723	1.06353580076937	NA	NA	NA	NA	0.978723875755847	0.827445910134532	1.03510849662781	1.031460814522	0.673874492552302	NA	NA	NA	NA	0.649090195974188	0.638991106554487	0.698658789130416	0.703635416247412	NA	NA	p.Glu225Ala	1	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.913	-2.779	0.866	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225C	225	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu225Cys	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.913	-4.329	2.416	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225D	225	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu225Asp	1	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.913	-2.239	0.326	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225E	225	E	E	synonymous	wt-like	1.32393273524864	0.23125100326071	4	0.115625501630355	1.09731091635876	1.55055455413851	NA	NA	NA	NA	1.50575287752188	1.54075058778564	1.10332514043708	1.14590233524995	0.727761541114928	NA	NA	NA	NA	0.726149598906006	0.776039563090302	0.712691298921735	0.729373483323849	NA	NA	p.Glu225=	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225F	225	E	F	missense	wt-like	1.08506868703884	0.364377092409156	4	0.182188546204578	0.727985698082151	1.44215167599552	NA	NA	NA	NA	0.761468695762758	1.29300359499539	1.49194915547028	0.793853301926917	0.689318321107691	NA	NA	NA	NA	0.617324288599048	0.72843950656873	0.792633230854691	0.650197135646651	NA	NA	p.Glu225Phe	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.913	-4.782	2.869	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225G	225	E	G	missense	wt-like	0.882385876798631	0.0600141961491456	4	0.0300070980745728	0.823573045291907	0.941198708305355	NA	NA	NA	NA	0.8405901773044	0.827626587318449	0.957104040620912	0.904222701950763	0.657022598567035	NA	NA	NA	NA	0.62889301462029	0.639025820373088	0.682612876702596	0.675019376760983	NA	NA	p.Glu225Gly	1	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.913	-3.064	1.151	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225H	225	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu225His	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.913	-3.504	1.591	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225I	225	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu225Ile	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.913	-3.861	1.948	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225K	225	E	K	missense	wt-like	0.947173306622326	0.21666693274403	4	0.108333466372015	0.734843614212795	1.15950299903186	NA	NA	NA	NA	0.876096421445878	0.672757789388792	1.09997734811886	1.13986166753577	0.673043595778388	NA	NA	NA	NA	0.634084550502993	0.609270611432487	0.712002641053782	0.728014928231038	NA	NA	p.Glu225Lys	1	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.913	-2.574	0.661	0.017324468	NA	NA	NA	NA	4.06e-06	NA	NA
E225L	225	E	L	missense	wt-like	1.52908272517636	0.481080621382363	4	0.240540310691182	1.05763237939157	2.00053307096115	NA	NA	NA	NA	2.15847771163258	1.05151981535062	1.28201642941973	1.6243169443025	0.785518293891547	NA	NA	NA	NA	0.821587583963365	0.682042811978516	0.749449003819729	0.836969635662771	NA	NA	p.Glu225Leu	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.913	-3.588	1.675	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225M	225	E	M	missense	low	0.55521803625388	0.167559241463534	4	0.0837796207317668	0.391012996981192	0.719423075526568	NA	NA	NA	NA	0.674366183148269	0.397810886110988	0.425144436854315	0.723550638901947	0.588887352550438	NA	NA	NA	NA	0.604588618278359	0.556444589251324	0.573186086822516	0.63438596287405	NA	NA	p.Glu225Met	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.913	-5.138	3.225	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225N	225	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu225Asn	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.913	-3.074	1.161	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225P	225	E	P	missense	possibly_wt-like	0.942109814983073	0.243767788152311	4	0.121883894076155	0.703221772298314	1.18099785766783	NA	NA	NA	NA	1.02338206030268	1.21906170845814	0.638904217036298	0.887091274135171	0.663393186842309	NA	NA	NA	NA	0.65561988034766	0.714232924527735	0.617157558312387	0.671166493336959	NA	NA	p.Glu225Pro	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.913	-2.413	0.5	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225Q	225	E	Q	missense	wt-like	1.31026185120878	0.0617626903848131	4	0.0308813451924066	1.24973552683751	1.37078817558004	NA	NA	NA	NA	1.39965831303831	1.28764776368095	1.29572302027232	1.25801830784353	0.739839500291403	NA	NA	NA	NA	0.710637010858632	0.727410481471732	0.752268519111074	0.75458853118933	NA	NA	p.Glu225Gln	1	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.913	-2.538	0.625	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225R	225	E	R	missense	wt-like	0.967124031470599	0.0820153417806989	4	0.0410076708903495	0.886750473435642	1.04749758950556	NA	NA	NA	NA	0.977798651901905	0.849342210977361	1.03579497170425	1.00556029129888	0.673382632465142	NA	NA	NA	NA	0.648954914618657	0.643198080556446	0.698800000537102	0.697810350311628	NA	NA	p.Glu225Arg	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.913	-2.786	0.873	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225S	225	E	S	missense	wt-like	0.985997619706616	0.121058782206142	4	0.0605293911030709	0.867362193138458	1.10463304627477	NA	NA	NA	NA	1.15238525966128	0.902698262533426	0.998722370163621	0.890184586468133	0.673172116048449	NA	NA	NA	NA	0.674482048246498	0.653449470659036	0.691173978278324	0.671862183850399	NA	NA	p.Glu225Ser	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.913	-2.679	0.766	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225T	225	E	T	missense	wt-like	0.951361026055131	0.194656831740744	4	0.0973284158703719	0.760600836276865	1.1421212158334	NA	NA	NA	NA	0.810768970238123	0.769226102772644	1.17852055831536	1.04692847289439	0.667459675067921	NA	NA	NA	NA	0.624532714895734	0.627805234670072	0.728159377952267	0.70711411546577	NA	NA	p.Glu225Thr	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.913	-3.553	1.64	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225V	225	E	V	missense	wt-like	1.06578118759078	0.0643188170075716	4	0.0321594085037858	1.00274990515925	1.12881247002231	NA	NA	NA	NA	0.978198822864034	1.10801291731454	1.05740653722124	1.1195064729633	0.698071269105132	NA	NA	NA	NA	0.649013425507638	0.692896928980203	0.70324560923006	0.723437014900913	NA	NA	p.Glu225Val	1	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.913	-3.34	1.427	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225W	225	E	W	missense	possibly_wt-like	0.789659528527437	0.163924895259313	4	0.0819624476296563	0.629016083088561	0.950302973966314	NA	NA	NA	NA	0.594718455678818	0.715061250552238	0.94342207201964	0.905436335859053	0.646345386561186	NA	NA	NA	NA	0.592942947351132	0.617398448302511	0.679798426333289	0.675292324819862	NA	NA	p.Glu225Trp	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.913	-4.399	2.486	0.017324468	NA	NA	NA	NA	NA	NA	NA
E225X	225	E	X	nonsense	low	-0.461662090841248	0.407709054843306	3	0.235390932564831	-0.923019840955613	-0.000304340726882957	NA	NA	NA	NA	-0.911279640515829	-0.357723981054214	NA	-0.1159826509537	0.411282373653702	NA	NA	NA	NA	0.372743843088679	0.411282373653702	NA	0.445573685741051	NA	NA	p.Glu225Ter	1	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E225Y	225	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu225Tyr	0	31.3	-3.8	26.4	0.891	120.3	62.1	-52.6	-42.8	64.018691588785	-2.7	0	0	27.49	0	0	1	3	5	22.148213127373	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.913	-4.693	2.78	0.017324468	NA	NA	NA	NA	NA	NA	NA
R226A	226	R	A	missense	wt-like	1.11594478241993	0.0957926841361792	4	0.0478963420680896	1.02206967697526	1.20981988786459	NA	NA	NA	NA	1.22739995953944	1.07779823208241	1.00524919063534	1.15333174742253	0.689804153912257	NA	NA	NA	NA	0.685450302297699	0.687091729455344	0.692516578369171	0.73104436909695	NA	NA	p.Arg226Ala	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.912	-3.188	1.276	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226C	226	R	C	missense	wt-like	1.23185023754503	0.209309100223269	4	0.104654550111634	1.02673108850798	1.43696938658208	NA	NA	NA	NA	1.39342002789617	1.34697917207001	1.25749834066029	0.929503409553656	0.724267404430248	NA	NA	NA	NA	0.709724881684031	0.738809927176465	0.744405508546884	0.680705045248122	NA	NA	p.Arg226Cys	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.912	-4.307	2.395	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226D	226	R	D	missense	wt-like	1.79587067628885	0.169448813106207	4	0.0847244065531036	1.62981389083324	1.96192746174447	NA	NA	NA	NA	1.84079956550006	1.90434973134888	1.8932146740266	1.54511873427988	0.832528167074396	NA	NA	NA	NA	0.77513835975857	0.845898492919806	0.875175584210623	0.819157841228987	NA	NA	p.Arg226Asp	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.912	-4.049	2.137	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226E	226	R	E	missense	wt-like	1.32844265029955	0.0950119487220042	4	0.0475059743610021	1.23533265150151	1.4215526490976	NA	NA	NA	NA	1.3503234954017	1.35067880439382	1.41848999011108	1.19427831129161	0.739887027854901	NA	NA	NA	NA	0.703423533842968	0.739520743908242	0.777522307777807	0.740253311801561	NA	NA	p.Arg226Glu	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.912	-2.994	1.082	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226F	226	R	F	missense	wt-like	0.977746878099743	0.125939957574634	4	0.062969978787317	0.85432798756935	1.10116576863014	NA	NA	NA	NA	0.825080903660829	1.03953576435242	1.11354174446023	0.932829099925496	0.680596646770479	NA	NA	NA	NA	0.626625330369755	0.67974029561516	0.714792906212615	0.681452997925798	NA	NA	p.Arg226Phe	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.912	-3.558	1.646	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226G	226	R	G	missense	wt-like	0.932753951146774	0.0534052821878074	4	0.0267026410939037	0.880417736310623	0.985090165982924	NA	NA	NA	NA	0.975630225719649	0.928528237671754	0.967986932962346	0.858870408233348	0.661615903592433	NA	NA	NA	NA	0.648637858770978	0.658412228279977	0.684851542881572	0.664819578904889	NA	NA	p.Arg226Gly	1	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.912	-2.638	0.726	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226H	226	R	H	missense	possibly_low	0.246520092644431	0.516036381737238	2	0.364892824865371	-0.468656702308777	0.96169688759764	NA	NA	NA	NA	0.611412917509802	-0.11837273222094	NA	NA	0.526326632498632	NA	NA	NA	NA	0.595383923571896	0.457269341425367	NA	NA	NA	NA	p.Arg226His	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.912	-3.326	1.414	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226I	226	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg226Ile	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.912	-3.799	1.887	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226K	226	R	K	missense	wt-like	1.05346990801687	0.0942245660582222	4	0.0471122830291111	0.961131530050359	1.14580828598339	NA	NA	NA	NA	1.0005885183904	1.12817121516742	1.13748103618334	0.947638862326339	0.690776856420933	NA	NA	NA	NA	0.652287128782611	0.696769977473622	0.719717339998028	0.684783735368244	NA	NA	p.Arg226Lys	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.912	-2.244	0.332	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226L	226	R	L	missense	wt-like	1.12185682946133	0.131497884529118	4	0.0657489422645591	0.992991270601192	1.25072238832147	NA	NA	NA	NA	1.18761208222581	0.925692250464755	1.17021676931279	1.20390621584196	0.703041987498228	NA	NA	NA	NA	0.679632728578911	0.657867345172307	0.726451246417544	0.74241864175826	NA	NA	p.Arg226Leu	1	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.912	-2.872	0.96	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226M	226	R	M	missense	wt-like	1.01835178497139	0.161225715473391	4	0.0806128577366954	0.860353487116617	1.17635008282616	NA	NA	NA	NA	1.07174035674019	1.21211049140929	0.835416838978669	0.954139452757412	0.674468151669937	NA	NA	NA	NA	0.662690575580345	0.712897375221194	0.657581201833083	0.68624572775953	NA	NA	p.Arg226Met	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.912	-3.911	1.999	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226N	226	R	N	missense	wt-like	0.976430598510135	0.255367349567987	4	0.127683674783993	0.726175194519783	1.22668600250049	NA	NA	NA	NA	0.949277504157604	1.30193622175888	0.678192044016422	0.976316624107635	0.668009054537389	NA	NA	NA	NA	0.644784702716197	0.730155747537146	0.625239263685048	0.691233406358581	NA	NA	p.Arg226Asn	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.912	-2.639	0.727	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226P	226	R	P	missense	wt-like	0.808720972871006	0.0849204022293565	4	0.0424602011146782	0.725500507909909	0.891941437832103	NA	NA	NA	NA	0.877098924434574	0.726617961454849	0.744436518438239	0.886730487156362	0.636548609716032	NA	NA	NA	NA	0.634231131206308	0.619618859077117	0.638866088225757	0.671085351812433	NA	NA	p.Arg226Pro	1	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.912	-3.303	1.391	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226Q	226	R	Q	missense	wt-like	1.34190745672464	0.216374658132606	4	0.108187329066303	1.12986418817111	1.55395072527818	NA	NA	NA	NA	1.41338582963498	1.59746618089636	1.08740009755865	1.26937771880857	0.734893727740586	NA	NA	NA	NA	0.71264417598452	0.786936427699311	0.709415436791322	0.757143279496652	rs139392616  	*40	p.Arg226Gln	1	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.912	-3.016	1.104	0.017622644	1.067092652	0.0185592148102859	NA	NA	6.13e-05	12.81	0.95348095
R226R	226	R	R	synonymous	wt-like	0.805369124314182	0.0357310239303821	4	0.017865511965191	0.770353364297038	0.840384884331326	NA	NA	NA	NA	0.756064747434948	0.819342924372524	0.840060931989763	0.806007893459495	0.645182493589627	NA	NA	NA	NA	0.616534151756066	0.63743426594092	0.658536515331533	0.652930721238334	NA	NA	p.Arg226=	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226S	226	R	S	missense	wt-like	0.981797696052854	0.0633356527806709	4	0.0316678263903355	0.91972989685913	1.04386549524658	NA	NA	NA	NA	1.04794862001482	1.02331825343095	0.919663179374573	0.936260731391075	0.675767749428682	NA	NA	NA	NA	0.659211873230713	0.676624397303713	0.674911101553651	0.682224776911964	NA	NA	p.Arg226Ser	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.912	-2.449	0.537	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226T	226	R	T	missense	possibly_low	0.7001294374379	0.131735296575658	4	0.0658676482878291	0.571031219047404	0.829227655828397	NA	NA	NA	NA	0.604915264050836	0.581058820523883	0.861401439959888	0.753142225216995	0.617737512640516	NA	NA	NA	NA	0.594433870929009	0.591652330573535	0.662926366111642	0.641041154352023	NA	NA	p.Arg226Thr	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.912	-3.149	1.237	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226V	226	R	V	missense	possibly_low	0.679245822415042	0.0718803023255023	4	0.0359401511627512	0.608804420537125	0.74968722429296	NA	NA	NA	NA	0.713483117064237	0.758196955093996	0.651712319775662	0.593590897726274	0.615050170114643	NA	NA	NA	NA	0.610308090189748	0.625686185526526	0.619792250039539	0.605157825093816	NA	NA	p.Arg226Val	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.912	-3.455	1.543	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226W	226	R	W	missense	wt-like	1.01966737083823	0.131575840690434	4	0.0657879203452169	0.890725416343816	1.14860932533265	NA	NA	NA	NA	1.13753993130454	1.12296027809848	0.947269439591136	0.870899834358772	0.676450645971188	NA	NA	NA	NA	0.67231144257648	0.695768791157622	0.680589849365897	0.667525014611595	NA	NA	p.Arg226Trp	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.912	-4.043	2.131	0.017622644	NA	NA	NA	NA	NA	NA	NA
R226X	226	R	X	nonsense	low	0.258267355358211	0.317537519541431	4	0.158768759770716	-0.0529136956624836	0.569448406378905	NA	NA	NA	NA	-0.0231911883797354	-0.00306178447200916	0.591585195177945	0.467737199106642	0.539724299120019	NA	NA	NA	NA	0.502595455889736	0.479424232463952	0.607423795399636	0.576853142350301	NA	NA	p.Arg226Ter	1	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R226Y	226	R	Y	missense	wt-like	1.03771524366787	0.142239408075131	4	0.0711197040375656	0.898323185163098	1.17710730217265	NA	NA	NA	NA	1.16127489039636	1.09828105242285	0.834275111439456	1.05702992041283	0.68340448610657	NA	NA	NA	NA	0.675781843199782	0.691027129013358	0.657346342684664	0.709385945935558	NA	NA	p.Arg226Tyr	0	28.6	-3.1	23.7	0.692	89.8	70.2	-55.1	-23.1	27.1698113207547	-1.9	0	0	25.14	0	0	0	0	6	18.903029560198	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.912	-3.707	1.795	0.017622644	NA	NA	NA	NA	NA	NA	NA
H227A	227	H	A	missense	possibly_wt-like	0.865162393365591	0.178317962344478	4	0.0891589811722391	0.690414001369717	1.03991078536146	NA	NA	NA	NA	1.02831623920771	0.809700784597231	0.984373939583613	0.638258610073814	0.645961517498411	NA	NA	NA	NA	0.656341329981561	0.63558170501526	0.688222433298085	0.615203659588492	NA	NA	p.His227Ala	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-2.452	-2.836	0.384	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227C	227	H	C	missense	low	0.495505549282916	0.103353165839248	4	0.051676582919624	0.394221307916355	0.596789790649476	NA	NA	NA	NA	0.488084317850763	0.637185204573048	0.466486500561861	0.390266174145992	0.579520912423606	NA	NA	NA	NA	0.577351465733149	0.602435989430511	0.581690359114063	0.559429794388528	NA	NA	p.His227Cys	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-2.452	-5.507	3.055	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227D	227	H	D	missense	possibly_low	0.568044739960326	0.284075679253239	4	0.14203783962662	0.289655689850275	0.846433790070377	NA	NA	NA	NA	0.496955978022532	0.272398372734707	0.954376908131872	0.548447700952193	0.586826843287278	NA	NA	NA	NA	0.578648633125379	0.532348867006666	0.682051891710991	0.595005053449176	NA	NA	p.His227Asp	1	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-2.452	-3.516	1.064	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227E	227	H	E	missense	wt-like	0.887773519337976	0.0926109444855511	4	0.0463054722427755	0.797016461455016	0.978530577220935	NA	NA	NA	NA	0.823306246579375	0.982824769053978	0.794790147930579	0.95017291378797	0.659034199859715	NA	NA	NA	NA	0.626365849364635	0.668844314391744	0.649224085327686	0.685353647285525	NA	NA	p.His227Glu	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-2.452	-3.183	0.731	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227F	227	H	F	missense	possibly_low	0.651034762785399	0.133875975472731	4	0.0669379877363653	0.519838717624539	0.782230807946259	NA	NA	NA	NA	0.721960285266062	0.451700493188872	0.734724342060191	0.695753930626472	0.619841009582028	NA	NA	NA	NA	0.611547577045303	0.566798492295484	0.636868244261152	0.628134442118754	NA	NA	p.His227Phe	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-2.452	-2.339	-0.113	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227G	227	H	G	missense	possibly_wt-like	0.774150836002741	0.0857833112785378	4	0.0428916556392689	0.69008473571248	0.858216936293002	NA	NA	NA	NA	0.700022276128695	0.728163600680928	0.894427327707561	0.77399013949378	0.632822853237929	NA	NA	NA	NA	0.608339916973516	0.619915825404315	0.669719958808491	0.645729881071543	NA	NA	p.His227Gly	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-2.452	-2.692	0.24	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227I	227	H	I	missense	possibly_wt-like	0.925131868302943	0.265006057173077	4	0.132503028586539	0.665430704430846	1.18483303217504	NA	NA	NA	NA	0.964387517536658	0.662455378605509	1.27682796602616	0.796856611043439	0.648933296769454	NA	NA	NA	NA	0.646994009235155	0.607291191500606	0.74838171057124	0.650872584303753	NA	NA	p.His227Ile	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-2.452	-3.477	1.025	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227K	227	H	K	missense	wt-like	1.09112528850373	0.148211932650956	4	0.074105966325478	0.945880263466256	1.23637031354121	NA	NA	NA	NA	1.14051855774236	0.872140880406681	1.19964729587726	1.15219441998862	0.701767772056127	NA	NA	NA	NA	0.672746961635367	0.647578428189448	0.732505255074643	0.730788582476888	NA	NA	p.His227Lys	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-2.452	-2.954	0.502	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227L	227	H	L	missense	wt-like	0.971530753683488	0.191466942235623	4	0.0957334711178115	0.783896598177572	1.1591649091894	NA	NA	NA	NA	1.20087518450197	0.735019032316325	1.00172663851751	0.948502159398154	0.683274940822797	NA	NA	NA	NA	0.681571989490549	0.62123297129436	0.691791971523631	0.684977892155046	NA	NA	p.His227Leu	1	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-2.452	-3.009	0.557	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227M	227	H	M	missense	wt-like	1.0215126578893	0.120649770757577	4	0.0603248853787884	0.903278055175368	1.13974726060323	NA	NA	NA	NA	0.985778846958808	1.14196853077773	1.08936429656186	0.8689389572588	0.683252444972821	NA	NA	NA	NA	0.650121736680258	0.699420879490637	0.709819482493448	0.667084010455004	NA	NA	p.His227Met	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-2.452	-3.577	1.125	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227N	227	H	N	missense	possibly_wt-like	0.763136734930754	0.0630643137872609	4	0.0315321568936305	0.701334843064372	0.824938626797136	NA	NA	NA	NA	0.836931428980347	0.71234577766924	0.794304286838921	0.708965446234507	0.629731891610092	NA	NA	NA	NA	0.62835805172378	0.616876719819522	0.64912414123567	0.631105731496404	NA	NA	p.His227Asn	1	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-2.452	-3.292	0.84	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227P	227	H	P	missense	wt-like	0.791730599332805	0.0339604574860013	4	0.0169802287430007	0.758449962547272	0.825011236118338	NA	NA	NA	NA	0.773146032994602	0.79929964904561	0.835946177237798	0.758530538053208	0.637918155396309	NA	NA	NA	NA	0.619031687303681	0.633583316923564	0.657690089399069	0.642252993869054	NA	NA	p.His227Pro	1	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-2.452	-2.641	0.189	0.024474517	NA	NA	NA	NA	4.06e-06	NA	NA
H227Q	227	H	Q	missense	possibly_wt-like	0.769608188144105	0.272138562096703	8	0.0962155113404674	0.581029251162684	0.958187125125526	0.824483807740196	1.27142362591596	0.530193175440596	0.997925404138233	0.772869423963037	0.529786318399182	0.458788219731867	0.771395529823767	0.632068796256344	0.648894450699224	0.732224366141521	0.577162966985234	0.723649119432451	0.618991242988953	0.581801256412549	0.58010678368304	0.645146349523734	rs72552736	*7	p.His227Gln	1	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-2.452	-2.685	0.233	0.024474517	NA	NA	1.22	0.085	4.06e-06	NA	NA
H227R	227	H	R	missense	wt-like	0.894787475062188	0.151755379641137	4	0.0758776898205683	0.746069935783772	1.0435050143406	NA	NA	NA	NA	1.06349839291875	0.74929688986641	0.981127831040321	0.785226786423274	0.654871249317778	NA	NA	NA	NA	0.661485479069645	0.623976200662098	0.687554692298619	0.648257019565911	NA	NA	p.His227Arg	1	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-2.452	-3.047	0.595	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227S	227	H	S	missense	possibly_wt-like	0.724111182108681	0.0808027850279143	4	0.0404013925139572	0.644925907856059	0.803296456361303	NA	NA	NA	NA	0.779859762653737	0.613552379781935	0.788624492862965	0.714408093136088	0.626171562147365	NA	NA	NA	NA	0.620013333469727	0.597895374090837	0.647955778793168	0.632329790825004	NA	NA	p.His227Ser	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-2.452	-3.053	0.601	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227T	227	H	T	missense	wt-like	1.27774635946882	0.209191851842701	4	0.10459592592135	1.07274211173335	1.48275060720428	NA	NA	NA	NA	1.52753413449382	1.06019190028088	1.36419754261832	1.15906186048225	0.730833709745758	NA	NA	NA	NA	0.729334339502326	0.683708994595674	0.766354075825983	0.73233307998919	NA	NA	p.His227Thr	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-2.452	-3.342	0.89	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227V	227	H	V	missense	wt-like	1.06151525836064	0.103557827520815	4	0.0517789137604077	0.960030452231639	1.16300006448965	NA	NA	NA	NA	1.08980195949702	1.00706512469311	1.19305678596322	0.956137163289222	0.680098335744602	NA	NA	NA	NA	0.665331447941769	0.673501655679848	0.731149553742325	0.686695015809356	NA	NA	p.His227Val	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-2.452	-4	1.548	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227W	227	H	W	missense	possibly_low	0.703188535370307	0.120551990534765	4	0.0602759952673827	0.58504975551393	0.821327315226684	NA	NA	NA	NA	0.530070386330802	0.806714057768794	0.722342708339501	0.753626989042131	0.634664569709832	NA	NA	NA	NA	0.583490447378722	0.635007860044442	0.634321279375223	0.641150178452438	NA	NA	p.His227Trp	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-2.452	-2.866	0.414	0.024474517	NA	NA	NA	NA	NA	NA	NA
H227X	227	H	X	nonsense	low	-0.253993213097055	0.185174551980194	2	0.130938181408376	-0.510627332858644	0.00264090666453431	NA	NA	NA	NA	-0.384931394505431	-0.123055031688679	NA	NA	0.453036716332104	NA	NA	NA	NA	0.449703709501832	0.456369723162376	NA	NA	NA	NA	p.His227Ter	0	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H227Y	227	H	Y	missense	wt-like	1.06916139335934	0.0944167483795467	4	0.0472083741897734	0.976634680178696	1.16168810653999	NA	NA	NA	NA	1.02169335059692	1.2054692454351	1.05608048711588	0.993402490289482	0.699024438449161	NA	NA	NA	NA	0.655372966114827	0.711621381191215	0.702972833994454	0.695076042903868	NA	NA	p.His227Tyr	1	31.4	-2.3	21.2	0.702	77.7	77	-75.7	-17.8	1.85185185185185	-5.3	0	0	21.41	1	3	0	0	7	18.6953897868162	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-2.452	-3.318	0.866	0.024474517	NA	NA	NA	NA	NA	NA	NA
K228A	228	K	A	missense	wt-like	0.882285841551505	0.130105710772531	4	0.0650528553862655	0.754784587902932	1.00978709520008	NA	NA	NA	NA	0.882750505487527	0.709042509948415	1.02272508782235	0.914625262947731	0.65620820184907	NA	NA	NA	NA	0.635057475601212	0.61624205730174	0.696111459100543	0.677358928096929	NA	NA	p.Lys228Ala	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.85	-2.438	0.588	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228C	228	K	C	missense	wt-like	0.956699423738535	0.142618704913646	4	0.0713093524568228	0.816935661162289	1.09646318631478	NA	NA	NA	NA	1.11788793493313	0.987841701308624	0.772292482375953	0.948775576336434	0.66962312873573	NA	NA	NA	NA	0.669438031242901	0.66980822622856	0.644596201360544	0.685039384028385	NA	NA	p.Lys228Cys	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.85	-5.431	3.581	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228D	228	K	D	missense	wt-like	1.43625778607773	0.311442649385784	4	0.155721324692892	1.13104959805479	1.74146597410067	NA	NA	NA	NA	1.85801077431164	1.23623414866169	1.48115347220677	1.16963274913083	0.756182690230988	NA	NA	NA	NA	0.777654891999322	0.717532295047216	0.79041250402558	0.734710488462654	NA	NA	p.Lys228Asp	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.85	-3.584	1.734	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228E	228	K	E	missense	wt-like	1.00023126176034	0.0799513785927348	4	0.0399756892963674	0.921880350482292	1.07858217303838	NA	NA	NA	NA	1.0160933804327	0.905853039408296	1.09837659527037	0.980602031929975	0.673375684450363	NA	NA	NA	NA	0.654554167992058	0.654055603374777	0.711673358069958	0.692197200908668	NA	NA	p.Lys228Glu	1	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.85	-2.796	0.946	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228F	228	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys228Phe	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.85	-4.637	2.787	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228G	228	K	G	missense	wt-like	0.866055505539114	0.0510425658413489	4	0.0255212829206744	0.816034710175335	0.916076300902893	NA	NA	NA	NA	0.832737312459672	0.822023047809505	0.934526045902796	0.874935615984483	0.653190935267618	NA	NA	NA	NA	0.627744810111219	0.637949202673948	0.677968468618901	0.668432667861287	NA	NA	p.Lys228Gly	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.85	-3.288	1.438	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228H	228	K	H	missense	wt-like	1.40454395774766	0.362908691475265	4	0.181454345737633	1.04889997526362	1.7601879402317	NA	NA	NA	NA	1.84911513613881	1.46210365243595	1.33798298875058	0.968974053665279	0.760945300493659	NA	NA	NA	NA	0.776354218670153	0.760928991915527	0.76096160907179	0.689582051418899	NA	NA	p.Lys228His	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.85	-3.827	1.977	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228I	228	K	I	missense	possibly_wt-like	0.776558942986803	0.199055521987839	4	0.0995277609939196	0.58148811597681	0.971629769996796	NA	NA	NA	NA	0.602203183140605	1.00979804445229	0.874269285722865	0.619965258631453	0.638331402553103	NA	NA	NA	NA	0.594037324752338	0.674026736261213	0.665573347281912	0.611089457824295	NA	NA	p.Lys228Ile	1	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.85	-2.869	1.019	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228K	228	K	K	synonymous	wt-like	1.78996264608189	0.211707678278675	4	0.105853839139338	1.58249293374349	1.99743235842029	NA	NA	NA	NA	2.01052866093893	1.92993788810767	1.6344204312473	1.58496360403365	0.825029653270165	NA	NA	NA	NA	0.799955253536427	0.850814789558904	0.821940295240804	0.828119011299527	NA	NA	p.Lys228=	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228L	228	K	L	missense	wt-like	1.08421166972253	0.214453918237751	4	0.107226959118875	0.874050691677786	1.29437264776727	NA	NA	NA	NA	1.28528622439598	1.22508510339174	0.815179185541673	1.01129616556073	0.696507241881098	NA	NA	NA	NA	0.693914126855456	0.715390209772904	0.653418213826784	0.699100356906739	NA	NA	p.Lys228Leu	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.85	-2.893	1.043	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228M	228	K	M	missense	low	0.279884084660825	0.273639866047104	4	0.136819933023552	0.0117219435674809	0.548046225754169	NA	NA	NA	NA	0.236798077030445	0.0319753204348801	0.669289435622331	0.181473505555645	0.526540865388615	NA	NA	NA	NA	0.540609716004561	0.486155971788562	0.623407951962829	0.512472014772668	NA	NA	p.Lys228Met	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.85	-4.082	2.232	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228N	228	K	N	missense	possibly_low	0.584065667335135	0.398537135903888	6	0.162702104419127	0.265175402464772	0.902955932205499	1.08830454659306	1.05096874693822	NA	NA	0.180095486971102	0.211241401994124	0.466537636158641	0.507246185355659	0.583719824845113	0.705087943537093	0.684559426650334	NA	NA	0.532318962137091	0.520598672862415	0.581700877965804	0.585738771724422	NA	NA	p.Lys228Asn	1	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.85	-3.461	1.611	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228P	228	K	P	missense	possibly_wt-like	0.899564975858413	0.244147526050408	4	0.122073763025204	0.660304796871737	1.13882515484509	NA	NA	NA	NA	0.931315739637224	0.689719860588534	1.23143117990478	0.745793123303112	0.640773379325127	NA	NA	NA	NA	0.642158428175509	0.612529563392861	0.739043361303812	0.639388330474745	NA	NA	p.Lys228Pro	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.85	-3.225	1.375	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228Q	228	K	Q	missense	wt-like	1.3167888258121	0.338613500481144	4	0.169306750240572	0.98495369300106	1.64862395862314	NA	NA	NA	NA	1.78430517598387	1.21674388312	0.978328912217217	1.28777733192732	0.73753448821071	NA	NA	NA	NA	0.7668780478772	0.713787596752572	0.686978940493823	0.761281379668849	NA	NA	p.Lys228Gln	1	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.85	-2.875	1.025	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228R	228	K	R	missense	wt-like	1.12203315876822	0.0456400259049009	4	0.0228200129524505	1.07730675525468	1.16675956228176	NA	NA	NA	NA	1.12059920456379	1.17569730715667	1.12756567023224	1.06427045312018	0.708457799919597	NA	NA	NA	NA	0.669834458798549	0.705901247401299	0.717677698907177	0.711014352437896	NA	NA	p.Lys228Arg	1	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.85	-2.043	0.193	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228S	228	K	S	missense	possibly_wt-like	0.991037337487828	0.502095430720879	4	0.251047715360439	0.498992856980304	1.48308181799535	NA	NA	NA	NA	0.315952433586132	1.14220123504484	1.51800982416955	0.987985857150788	0.696661711735665	NA	NA	NA	NA	0.552183248837089	0.69946558936236	0.797994042648852	0.693857834108971	NA	NA	p.Lys228Ser	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.85	-2.931	1.081	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228T	228	K	T	missense	possibly_low	0.461850150398311	1.08496102017645	2	0.767183294689842	-1.04180147673456	1.96550177753118	NA	NA	NA	NA	-0.305333144291531	1.22903344508815	NA	NA	0.588745478795207	NA	NA	NA	NA	0.461342146125522	0.716148811464893	NA	NA	NA	NA	p.Lys228Thr	1	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.85	-3.207	1.357	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228V	228	K	V	missense	wt-like	1.17179409656913	0.0826160324350131	4	0.0413080162175066	1.09083187251002	1.25275632062824	NA	NA	NA	NA	1.29297614072123	1.15517812287083	1.11461124022239	1.12441088246208	0.708485884046885	NA	NA	NA	NA	0.695038505890829	0.701958861175811	0.71501290691796	0.724540023842486	NA	NA	p.Lys228Val	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.85	-2.76	0.91	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228W	228	K	W	missense	wt-like	0.92777624192558	0.0875021759795215	4	0.0437510879897608	0.842025685181206	1.01352679866995	NA	NA	NA	NA	1.01632673945787	0.905789840853658	0.973329181135454	0.815659206255335	0.654844802131413	NA	NA	NA	NA	0.654588288518801	0.654043460927602	0.68595047043958	0.655101315744025	NA	NA	p.Lys228Trp	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.85	-4.316	2.466	0.017616208	NA	NA	NA	NA	NA	NA	NA
K228X	228	K	X	nonsense	low	0.327835434426546	0.189468894775856	4	0.094734447387928	0.142159329450902	0.513511539402189	NA	NA	NA	NA	0.102091577656644	0.288901547239866	0.359695214676843	0.56065339813283	0.547621250029237	NA	NA	NA	NA	0.520913641636744	0.535519650354563	0.559722849703911	0.597750132776606	NA	NA	p.Lys228Ter	1	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K228Y	228	K	Y	missense	possibly_wt-like	0.899184742581399	0.349665556052099	4	0.174832778026049	0.556518794333256	1.24185069082954	NA	NA	NA	NA	0.398358264330812	0.919249169538728	1.13852036404572	1.14061117241034	0.688280279973858	NA	NA	NA	NA	0.564232195088637	0.656629424934415	0.719931135013302	0.728183492984574	NA	NA	p.Lys228Tyr	0	32.5	-5.9	21	0.821	83.8	67.6	-53.8	-30.7	51.7391304347826	-4.2	0	0	23.41	0	0	1	3	8	21.8883339456742	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.85	-4.615	2.765	0.017616208	NA	NA	NA	NA	NA	NA	NA
S229A	229	S	A	missense	wt-like	1.37806251741422	0.102049607740122	4	0.0510248038700612	1.27805573951068	1.47806929531776	NA	NA	NA	NA	1.35096432830699	1.47001764213505	1.44550671717925	1.24576138203558	0.757140725428939	NA	NA	NA	NA	0.703517233052871	0.762449520389942	0.783079785629891	0.751831930467937	NA	NA	p.Ser229Ala	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.209	-2.108	-0.101	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229C	229	S	C	missense	low	-0.228447807353329	0.48051884391771	4	0.240259421958855	-0.699347621339096	0.242452006632439	NA	NA	NA	NA	-0.605974794117766	-0.424208421649944	-0.35864744114176	0.475039427496155	0.414670014425516	NA	NA	NA	NA	0.417383908619778	0.398508603548484	0.411956120231254	0.578495424302702	NA	NA	p.Ser229Cys	1	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.209	-5.445	3.236	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229D	229	S	D	missense	wt-like	1.21537942995306	0.345190666179399	4	0.172595333089699	0.877098793197556	1.55366006670857	NA	NA	NA	NA	1.34122522696043	1.60477825897019	1.126965070454	0.788549163427628	0.709823692734505	NA	NA	NA	NA	0.702093232983911	0.788341309856242	0.717554152485098	0.649004227062345	NA	NA	p.Ser229Asp	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.209	-2.651	0.442	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229E	229	S	E	missense	possibly_wt-like	0.847983986623431	0.142916659899689	4	0.0714583299498445	0.707928233526356	0.988039739720506	NA	NA	NA	NA	0.761924502055829	0.69279220888511	0.987098891517239	0.950120344035546	0.651366379231718	NA	NA	NA	NA	0.617390934192893	0.613119858963855	0.688782969738376	0.685341824270543	NA	NA	p.Ser229Glu	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.209	-2.3	0.091	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229F	229	S	F	missense	wt-like	1.11033935617856	0.205151276163668	4	0.102575638081834	0.909294799846955	1.31138391251017	NA	NA	NA	NA	0.810594548727277	1.23969930799424	1.14471499497937	1.24634857301337	0.719701732054876	NA	NA	NA	NA	0.624507211901706	0.718198062079252	0.7212054020305	0.751963990586302	NA	NA	p.Ser229Phe	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.209	-3.991	1.782	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229G	229	S	G	missense	wt-like	1.08773946257569	0.0969166213864245	4	0.0484583106932122	0.992762918865338	1.18271600628603	NA	NA	NA	NA	1.18723426956819	1.11921133840381	1.08825863214693	0.956253610183809	0.690884852901859	NA	NA	NA	NA	0.679577486803375	0.695048500915741	0.709592041712695	0.686721204887976	NA	NA	p.Ser229Gly	1	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.209	-2.998	0.789	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229H	229	S	H	missense	wt-like	1.01514460383954	0.114401500118898	4	0.0572007500594491	0.903033193834342	1.12725601384474	NA	NA	NA	NA	1.00005722656668	0.955390292120522	1.18036267788448	0.924768218786487	0.671606687463043	NA	NA	NA	NA	0.652209446092319	0.66357328107681	0.728538311295318	0.679640093849277	NA	NA	p.Ser229His	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.209	-4.978	2.769	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229I	229	S	I	missense	low	0.333790059477812	0.300097785102837	3	0.173261537012333	-0.00579631297241495	0.673376431928039	NA	NA	NA	NA	0.514072724707912	-0.0126368581528164	NA	0.499934311878341	0.5811513536119	NA	NA	NA	NA	0.5811513536119	0.477584557062562	NA	0.584094320577525	NA	NA	p.Ser229Ile	1	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.209	-3.806	1.597	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229K	229	S	K	missense	low	-0.282823100982711	0.0338683100352468	2	0.0239485116932514	-0.32976132138482	-0.235884880580602	NA	NA	NA	NA	-0.306771612675962	-0.25887458928946	NA	NA	0.44570314922116	NA	NA	NA	NA	0.461131820859799	0.430274477582522	NA	NA	NA	NA	p.Ser229Lys	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.209	-2.215	0.006	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229L	229	S	L	missense	wt-like	1.35705354803552	0.253665273983067	4	0.126832636991534	1.10846614746787	1.60564094860316	NA	NA	NA	NA	1.64476642122282	1.4152984762106	1.33741029953141	1.03073899517723	0.74920582968528	NA	NA	NA	NA	0.746475426595061	0.7519362327755	0.760843803993343	0.703473078010426	NA	NA	p.Ser229Leu	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.209	-3.506	1.297	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229M	229	S	M	missense	wt-like	0.971257198063319	0.0962585988430443	4	0.0481292994215221	0.876925504595991	1.06558889153065	NA	NA	NA	NA	1.09535283142495	0.980134882457742	0.863071244008263	0.946469834362324	0.667235284512654	NA	NA	NA	NA	0.6661430671792	0.668327501846109	0.663269853277676	0.684520819252129	NA	NA	p.Ser229Met	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.209	-4.159	1.95	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229N	229	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Asn	1	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.209	-2.713	0.504	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229P	229	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Pro	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.209	-3.239	1.03	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229Q	229	S	Q	missense	wt-like	1.46372663699277	0.111105685976421	4	0.0555528429882103	1.35484506549707	1.57260820848847	NA	NA	NA	NA	1.58226163928665	1.31700639756667	1.50082839664141	1.45481011447635	0.765898021316193	NA	NA	NA	NA	0.737336306811814	0.733051206376674	0.794459735820572	0.798847299222041	NA	NA	p.Ser229Gln	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.209	-2.418	0.209	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229R	229	S	R	missense	wt-like	1.17825364604602	0.103129837060189	4	0.0515649185300944	1.07718826286129	1.27931902923075	NA	NA	NA	NA	1.17675858015421	1.31501009718865	1.06559570303237	1.15565020380885	0.718247977777977	NA	NA	NA	NA	0.678045786709386	0.732667653745993	0.704930162192658	0.731565793363295	NA	NA	p.Ser229Arg	1	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.209	-2.933	0.724	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229S	229	S	S	synonymous	wt-like	1.02950381117126	0.127902184611619	4	0.0639510923058097	0.904161973479875	1.15484564886264	NA	NA	NA	NA	1.00990860083025	1.21482437505322	0.964202119798815	0.92908014900275	0.682341420466525	NA	NA	NA	NA	0.65364986211547	0.713418798360943	0.68407298760811	0.680609853324939	NA	NA	p.Ser229=	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229T	229	S	T	missense	low	0.388754487463166	0.0314068386296728	4	0.0157034193148364	0.357976351171956	0.419532623754376	NA	NA	NA	NA	0.385705232729937	0.358126438321107	0.378716450697585	0.432469828104036	0.563008874985419	NA	NA	NA	NA	0.562382135495761	0.54881994793257	0.563635614475077	0.568921458511247	NA	NA	p.Ser229Thr	1	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.209	-3.338	1.129	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229V	229	S	V	missense	possibly_wt-like	0.794494234138452	0.179339833893071	4	0.0896699169465354	0.618744426426545	0.970244041850359	NA	NA	NA	NA	0.76309512384743	1.05666843283412	0.687429632910562	0.670783746961693	0.624829046759997	NA	NA	NA	NA	0.617562096341499	0.683032024725208	0.627139482595958	0.622518610924035	NA	NA	p.Ser229Val	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.209	-3.57	1.361	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229W	229	S	W	missense	wt-like	0.968405169675345	0.163576637378803	4	0.0817883186894014	0.808103010688034	1.12870732866266	NA	NA	NA	NA	1.1149863442153	0.769291973890625	0.900437330765509	1.08890502982995	0.669985011437876	NA	NA	NA	NA	0.669013775940974	0.627817890601447	0.670956246934778	0.71655470513264	NA	NA	p.Ser229Trp	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.209	-5.852	3.643	0.026192296	NA	NA	NA	NA	NA	NA	NA
S229X	229	S	X	nonsense	possibly_wt-like	0.755799675389954	0.165310374435679	4	0.0826551872178394	0.593798485307574	0.917800865472335	NA	NA	NA	NA	0.800201758465633	0.564693591566222	0.701228950037573	0.957074401490389	0.626482852518668	NA	NA	NA	NA	0.622987632884851	0.588508050941319	0.629978072152485	0.686905802065383	NA	NA	p.Ser229Ter	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S229Y	229	S	Y	missense	wt-like	1.28472631547972	0.554965366900368	4	0.277482683450184	0.740870249583828	1.82858238137561	NA	NA	NA	NA	1.65668903871877	1.51137070580354	0.458606619030998	1.51223889836556	0.75930672231958	NA	NA	NA	NA	0.748218688887162	0.770394755751998	0.580069427497354	0.811763117558398	NA	NA	p.Ser229Tyr	0	29.5	-6.4	18.8	0.608	93.5	57.8	-68.6	-13.3	70.6293706293706	-1.9	0	0	24.37	1	3	0	0	6	20.0968780752609	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.209	-4.688	2.479	0.026192296	NA	NA	NA	NA	NA	NA	NA
W230A	230	W	A	missense	wt-like	1.14825226071005	0.0585888195833527	4	0.0292944097916764	1.09083627257	1.20566824885009	NA	NA	NA	NA	1.20668637815919	1.07038706547371	1.17573900155051	1.14019659765678	0.706627503429232	NA	NA	NA	NA	0.682421671599211	0.685667809247508	0.727587197610956	0.728090254510045	NA	NA	p.Trp230Ala	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	148	-0.9	1.8	-2.7	264	121	143	5.4	8.1	-2.7	204	89	115	5.89	6	0.11	-2.244	-2.354	0.11	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230C	230	W	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp230Cys	1	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	215	-0.9	2.5	-3.4	264	148	116	5.4	5.5	-0.0999999999999996	204	121	83	5.89	5.07	-0.82	-2.244	-4.248	2.004	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230D	230	W	D	missense	possibly_wt-like	0.785859889063115	0.114052650998095	4	0.0570263254990475	0.674090344914324	0.897629433211906	NA	NA	NA	NA	0.688206775827303	0.902063123155237	0.865502335260688	0.687667322009231	0.639821596065256	NA	NA	NA	NA	0.606612316793042	0.653327440236142	0.663769941084673	0.626315751894371	NA	NA	p.Trp230Asp	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	181	-0.9	-3.5	2.6	264	187	77	5.4	13	-7.6	204	133	71	5.89	5.05	-0.84	-2.244	-3.319	1.075	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230E	230	W	E	missense	possibly_wt-like	0.74777583140204	0.0889343531850996	4	0.0444671765925498	0.66062176678646	0.83492989601762	NA	NA	NA	NA	0.6303942452338	0.744258184575839	0.844480341703187	0.771970554095336	0.634141889433138	NA	NA	NA	NA	0.598159273270609	0.623008105534381	0.659445610335516	0.645275673331895	NA	NA	p.Trp230Glu	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	152	-0.9	-3.5	2.6	264	214	50	5.4	12.3	-6.9	204	147	57	5.89	3.22	-2.67	-2.244	-2.802	0.558	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230F	230	W	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp230Phe	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	40	-0.9	2.8	-3.7	264	228	36	5.4	5.2	0.2	204	165	39	5.89	3.32	-2.57	-2.244	-3.019	0.775	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230G	230	W	G	missense	possibly_wt-like	0.788518563565307	0.102309273255111	4	0.0511546366275553	0.688257318133066	0.888779808997549	NA	NA	NA	NA	0.84309806989419	0.636972653791342	0.856434150667749	0.817569379907948	0.642395311038661	NA	NA	NA	NA	0.629259705456921	0.602395151682658	0.661904569498148	0.655530916620402	NA	NA	p.Trp230Gly	1	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	184	-0.9	-9.4	8.5	264	97	167	5.4	9	-3.6	204	75	129	5.89	3.29	-2.6	-2.244	-2.921	0.677	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230H	230	W	H	missense	possibly_low	0.571305033428308	0.487479442924995	4	0.243739721462498	0.093583957759988	1.04902610909663	NA	NA	NA	NA	0.471865629139308	0.104045378545446	1.25721817897056	0.452090947057921	0.57415716585033	NA	NA	NA	NA	0.574980054550361	0.500002916209317	0.744347877865649	0.5733342771503	NA	NA	p.Trp230His	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	115	-0.9	-3.2	2.3	264	216	48	5.4	10.4	-5	204	155	49	5.89	7.59	1.7	-2.244	-5.032	2.788	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230I	230	W	I	missense	wt-like	1.1608340650171	0.362821930125865	4	0.181410965062933	0.805275107093095	1.5163930229411	NA	NA	NA	NA	0.690311621401637	1.11567400800764	1.55746335069361	1.2798872799655	0.726937881429783	NA	NA	NA	NA	0.606920076219333	0.694368867532923	0.80610983325853	0.759506895326644	NA	NA	p.Trp230Ile	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	61	-0.9	4.5	-5.4	264	191	73	5.4	5.2	0.2	204	131	73	5.89	6.02	0.13	-2.244	-3.263	1.019	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230K	230	W	K	missense	possibly_wt-like	0.78053576418869	0.218028740060837	4	0.109014370030418	0.566871525131747	0.994200003245632	NA	NA	NA	NA	0.782264148728647	0.570751894620747	1.08071879315759	0.688408220247772	0.623423635566016	NA	NA	NA	NA	0.620364890129283	0.589672043143898	0.708041058572294	0.62648238100275	NA	NA	p.Trp230Lys	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	110	-0.9	-3.9	3	264	230	34	5.4	11.3	-5.9	204	146	58	5.89	9.74	3.85	-2.244	-2.561	0.317	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230L	230	W	L	missense	possibly_wt-like	0.760178415364872	0.138976897412351	4	0.0694884487061757	0.623983558559209	0.896373272170535	NA	NA	NA	NA	0.604189767377773	0.681803234800384	0.875716439885943	0.879004219395389	0.638439781339419	NA	NA	NA	NA	0.594327792629204	0.611008528442116	0.665871034236722	0.669347702778957	NA	NA	p.Trp230Leu	1	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	61	-0.9	3.8	-4.7	264	191	73	5.4	4.9	0.5	204	131	73	5.89	9.71	3.82	-2.244	-2.924	0.68	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230M	230	W	M	missense	possibly_wt-like	0.812343733948736	0.142718189611939	4	0.0713590948059696	0.672482478159656	0.952204989737815	NA	NA	NA	NA	0.821765831235223	0.639148451008931	0.988063249619498	0.800397403931291	0.638904765903412	NA	NA	NA	NA	0.626140617951773	0.602813191350346	0.688981343093567	0.651668913855052	NA	NA	p.Trp230Met	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	67	-0.9	1.9	-2.8	264	203	61	5.4	5.7	-0.3	204	149	55	5.89	5.74	-0.15	-2.244	-3.495	1.251	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230N	230	W	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp230Asn	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	174	-0.9	-3.5	2.6	264	187	77	5.4	11.6	-6.2	204	132	72	5.89	5.47	-0.42	-2.244	-3.102	0.858	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230P	230	W	P	missense	possibly_low	0.603119789336023	0.141653393813862	4	0.0708266969069309	0.464302014254504	0.741937564417542	NA	NA	NA	NA	0.551831273777294	0.431516049512483	0.755051827123229	0.674080006931087	0.604966077155557	NA	NA	NA	NA	0.586672209650388	0.562920420359951	0.641049711088771	0.623259944660725	NA	NA	p.Trp230Pro	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	147	-0.9	-1.6	0.7	264	154	110	5.4	8	-2.6	204	115	89	5.89	6.3	0.41	-2.244	-4.445	2.201	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230Q	230	W	Q	missense	possibly_low	0.470614772910316	0.512000185970947	4	0.256000092985474	-0.0311361893801169	0.972365735200749	NA	NA	NA	NA	0.242709627247646	-0.143229221658381	0.850158007001423	0.932820679050576	0.601043803309352	NA	NA	NA	NA	0.541474071720494	0.452493621289173	0.660613534898209	0.681451104058589	NA	NA	p.Trp230Gln	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	130	-0.9	-3.5	2.6	264	214	50	5.4	10.5	-5.1	204	146	58	5.89	6.24	0.35	-2.244	-3.147	0.903	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230R	230	W	R	missense	possibly_low	0.703699684787691	0.133117835268283	4	0.0665589176341414	0.573246603374806	0.834152766200576	NA	NA	NA	NA	0.649925906114512	0.550354258703833	0.858763911892128	0.755754662440292	0.621321892562934	NA	NA	NA	NA	0.601015089782966	0.585753010215924	0.662383813204184	0.641628695342901	NA	NA	p.Trp230Arg	1	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	101	-0.9	-4.5	3.6	264	265	-1	5.4	10.5	-5.1	204	174	30	5.89	6.34	0.45	-2.244	-2.238	-0.006	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230S	230	W	S	missense	wt-like	0.903197958146385	0.143784366692115	4	0.0718921833460575	0.762291868018162	1.04410404827461	NA	NA	NA	NA	0.8991418621191	0.74112879001493	1.0909987481374	0.881522432314113	0.653684092980887	NA	NA	NA	NA	0.637454133377234	0.622406849566348	0.710155697476426	0.66991405258454	NA	NA	p.Trp230Ser	1	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	177	-0.9	-0.8	-0.1	264	143	121	5.4	9.2	-3.8	204	105	99	5.89	5.68	-0.21	-2.244	-2.979	0.735	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230T	230	W	T	missense	wt-like	1.01477758910645	0.246432371959581	4	0.12321618597979	0.773278302273672	1.25627687593923	NA	NA	NA	NA	1.3051482136862	0.703596732739409	1.04545070918398	1.00491470081621	0.697241699152601	NA	NA	NA	NA	0.696818242246856	0.615195750745067	0.700786234733928	0.697665156058345	NA	NA	p.Trp230Thr	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	128	-0.9	-0.7	-0.2	264	163	101	5.4	8.6	-3.2	204	119	85	5.89	5.6	-0.29	-2.244	-3.548	1.304	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230V	230	W	V	missense	low	0.647562949670461	0.0205138158617662	4	0.0102569079308831	0.627459779533187	0.667666119807735	NA	NA	NA	NA	0.67470333997473	0.648737679633606	0.641266564048174	0.625544215025335	0.608499879862285	NA	NA	NA	NA	0.604637915572539	0.604655586365486	0.617643505080266	0.612344173359084	NA	NA	p.Trp230Val	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	88	-0.9	4.2	-5.1	264	165	99	5.4	5.9	-0.5	204	117	87	5.89	5.61	-0.28	-2.244	-3.376	1.132	0.022628372	NA	NA	NA	NA	NA	NA	NA
W230X	230	W	X	nonsense	low	0.415479145992902	0.293836535526677	6	0.11995826330459	0.180365270267932	0.650593021717871	0.163192930013651	-0.063966727985002	NA	NA	0.643332166570863	0.602793551798025	0.550603450192003	0.596919505367871	0.597410952216728	0.508040307227207	0.443497254675631	NA	NA	0.600050987939199	0.595828261935924	0.598993642497531	0.60590643386977	NA	NA	p.Trp230Ter	1	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	NA	-0.9	NA	NA	264	NA	NA	5.4	NA	NA	204	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
W230Y	230	W	Y	missense	possibly_low	0.689869732671004	0.20369005084496	4	0.10184502542248	0.490257150838377	0.889482314503631	NA	NA	NA	NA	0.824196806465535	0.874748219292218	0.427070542714655	0.633463362211609	0.620310631798872	NA	NA	NA	NA	0.626496062337494	0.648079380701221	0.573582296571854	0.614125201260251	NA	NA	p.Trp230Tyr	0	31.1	-4.2	16.1	0.481	113.9	-116.2	-90.2	-7.1	13.2575757575758	-2.6	0	0	24.32	0	0	0	0	7	18.6511968713951	37	-0.9	-1.3	0.4	264	255	9	5.4	6.2	-0.8	204	181	23	5.89	5.66	-0.23	-2.244	-3.811	1.567	0.022628372	NA	NA	NA	NA	NA	NA	NA
G231A	231	G	A	missense	wt-like	0.901554748173052	0.109698118895734	4	0.0548490594478669	0.794052567069336	1.00905692927677	NA	NA	NA	NA	0.902798061254078	0.816440567159972	1.05604661462298	0.83093374965518	0.648262653332261	NA	NA	NA	NA	0.637988723544752	0.636876631049746	0.702965866250781	0.658536583119769	NA	NA	p.Gly231Ala	1	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.887	-2.484	1.597	0.037822866	NA	NA	NA	NA	4.06e-06	NA	NA
G231C	231	G	C	missense	wt-like	0.872427647142014	0.109475909212621	4	0.0547379546063107	0.765143227526257	0.979712066757771	NA	NA	NA	NA	0.832290853817992	0.779578457029319	0.847050203149105	1.03079107457164	0.644884247101513	NA	NA	NA	NA	0.627679531281692	0.629794250327535	0.659974243875492	0.703484790743167	NA	NA	p.Gly231Cys	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.887	-5.34	4.453	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231D	231	G	D	missense	possibly_wt-like	1.16969435300245	0.727581396285689	2	0.514477739178787	0.161336513364435	2.17805219264046	NA	NA	NA	NA	1.68417209218124	0.655216613823662	NA	NA	0.679068755633884	NA	NA	NA	NA	0.752237116115008	0.605900395152761	NA	NA	NA	NA	p.Gly231Asp	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.887	-3.763	2.876	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231E	231	G	E	missense	wt-like	1.00679201717588	0.0774679329323257	4	0.0387339664661628	0.930874837923815	1.08270919642794	NA	NA	NA	NA	1.08176811944109	0.983597809884344	0.908431171068564	1.05337096830951	0.670796730253705	NA	NA	NA	NA	0.664156782191146	0.668992840058209	0.672600620449202	0.708563042202144	NA	NA	p.Gly231Glu	1	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.887	-3.2	2.313	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231F	231	G	F	missense	low	0.413259092963054	0.29509598169458	4	0.14754799084729	0.12407034491112	0.702447841014987	NA	NA	NA	NA	0.388167183295384	0.173775055236614	0.255493200102024	0.835600933218192	0.550515037736521	NA	NA	NA	NA	0.56274210893173	0.51340019911616	0.538287966541312	0.659586239597931	NA	NA	p.Gly231Phe	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.887	-4.565	3.678	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231G	231	G	G	synonymous	wt-like	1.12671942361507	0.0715944433466144	4	0.0357972216733072	1.0565581583888	1.19688068884135	NA	NA	NA	NA	1.18964529043642	1.17795424853802	1.10337547636864	1.03590267911722	0.705484637796905	NA	NA	NA	NA	0.679930013567442	0.706334877436957	0.712701653278283	0.704634398156853	NA	NA	p.Gly231=	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231H	231	G	H	missense	wt-like	1.16904467634235	0.159486231811192	4	0.079743115905596	1.01275104115238	1.32533831153232	NA	NA	NA	NA	1.33338558139092	0.961953772958215	1.24285638925402	1.13798296176625	0.714269682927823	NA	NA	NA	NA	0.70094696132759	0.664834333957144	0.741393584843235	0.727592404528057	NA	NA	p.Gly231His	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.887	-4.862	3.975	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231I	231	G	I	missense	possibly_wt-like	1.02105522599995	0.761248576387806	3	0.439507070497719	0.159637196873711	1.88247325512618	NA	NA	NA	NA	1.14857502244971	0.204099854350323	1.7104908011998	NA	0.673924935443278	NA	NA	NA	NA	0.673924935443278	0.51922655501078	0.837588356352875	NA	NA	NA	p.Gly231Ile	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.887	-4.423	3.536	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231K	231	G	K	missense	wt-like	0.911221038131866	0.102536120611651	4	0.0512680603058253	0.810737486375221	1.01170458988851	NA	NA	NA	NA	0.913263904099932	0.858953172711051	1.05368682871162	0.818980247004863	0.650446436953018	NA	NA	NA	NA	0.639518983925447	0.645044651191261	0.702480446314275	0.655848222714775	NA	NA	p.Gly231Lys	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.887	-2.998	2.111	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231L	231	G	L	missense	wt-like	0.819177281420786	0.045561714228176	4	0.022780857114088	0.774527621940221	0.863826940901352	NA	NA	NA	NA	0.868830679952913	0.761200181757805	0.836869899496789	0.809808364475638	0.643403822430146	NA	NA	NA	NA	0.633022192075983	0.626263200639139	0.657880103755096	0.653785452784309	NA	NA	p.Gly231Leu	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.887	-3.947	3.06	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231M	231	G	M	missense	low	0.541383375796197	0.119675297145338	4	0.0598376485726691	0.424103739674201	0.658663011918193	NA	NA	NA	NA	0.542781679055763	0.710157562351603	0.455791761658877	0.456802500118544	0.582419711329121	NA	NA	NA	NA	0.585349025606096	0.616456294240879	0.579490397052146	0.574393912394022	NA	NA	p.Gly231Met	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.887	-5.078	4.191	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231N	231	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly231Asn	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.887	-2.694	1.807	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231P	231	G	P	missense	possibly_wt-like	0.797439603354074	0.102475843335261	4	0.0512379216676303	0.697015122242834	0.897864084465314	NA	NA	NA	NA	0.718297622453919	0.702264876215038	0.906835945414608	0.862359969332731	0.640272122603955	NA	NA	NA	NA	0.611012041792976	0.614939858856634	0.672272474437342	0.665604386351277	NA	NA	p.Gly231Pro	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.887	-4.176	3.289	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231Q	231	G	Q	missense	wt-like	1.43679131044388	0.147080676720982	4	0.0735403383604912	1.29265489584643	1.58092772504134	NA	NA	NA	NA	1.57259885842486	1.45407530183445	1.49146528057179	1.22902580094443	0.753727282320475	NA	NA	NA	NA	0.73592346592189	0.759386491083923	0.792533695332689	0.748068073557027	NA	NA	p.Gly231Gln	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.887	-3.201	2.314	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231R	231	G	R	missense	wt-like	0.952795825778643	0.0332273313285223	4	0.0166136656642612	0.920233639425501	0.985358012131784	NA	NA	NA	NA	0.978389054538003	0.918012141754073	0.983895924425886	0.930886182396609	0.668703892779191	NA	NA	NA	NA	0.64904124018039	0.656391752655106	0.688124103154492	0.681016032903275	NA	NA	p.Gly231Arg	1	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.887	-2.944	2.057	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231S	231	G	S	missense	wt-like	0.926979946359026	0.163060127315053	4	0.0815300636575263	0.767183957933016	1.08677593478504	NA	NA	NA	NA	1.12447067200188	0.84509456948702	0.986172390178124	0.752182153769084	0.656391249121109	NA	NA	NA	NA	0.670400524362777	0.642381973879442	0.688592383711466	0.640825232865072	NA	NA	p.Gly231Ser	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.887	-3.034	2.147	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231T	231	G	T	missense	low	0.540134042790832	0.152790617614106	4	0.076395308807053	0.390401988941193	0.689866096640472	NA	NA	NA	NA	0.532066358095942	0.396018519118643	0.479074849786376	0.753376444162368	0.58403106713927	NA	NA	NA	NA	0.583782287850451	0.556100218693352	0.58427984642809	0.641093830538849	NA	NA	p.Gly231Thr	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.887	-3.836	2.949	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231V	231	G	V	missense	possibly_low	0.699260333370268	0.170922748378214	4	0.0854613741891069	0.531759117890318	0.866761548850219	NA	NA	NA	NA	0.682138188258042	0.463985749899396	0.833955931303568	0.816961464020067	0.630559597671149	NA	NA	NA	NA	0.605724999903156	0.569158879831239	0.657280685711059	0.655394195439142	NA	NA	p.Gly231Val	1	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.887	-3.988	3.101	0.037822866	NA	NA	NA	NA	4.06e-06	NA	NA
G231W	231	G	W	missense	low	0.546996226395927	0.110092960629938	4	0.0550464803149689	0.439107107502895	0.654885345288959	NA	NA	NA	NA	0.556135537215926	0.525109348883655	0.687006769847595	0.419733249636533	0.584102109283611	NA	NA	NA	NA	0.587301556364764	0.580902662202458	0.627052497518122	0.566056983198129	NA	NA	p.Gly231Trp	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.887	-3.784	2.897	0.037822866	NA	NA	NA	NA	NA	NA	NA
G231X	231	G	X	nonsense	wt-like	0.907553733409349	0.141221652859747	4	0.0706108264298733	0.769159056688188	1.04594841013051	NA	NA	NA	NA	0.975953705733165	0.76735414048925	1.07174732937455	0.81515975804043	0.651837072708155	NA	NA	NA	NA	0.648685156313653	0.627445571331711	0.706195582947167	0.654988989102657	NA	NA	p.Gly231Ter	1	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G231Y	231	G	Y	missense	low	0.526655558186319	0.0384818488430696	2	0.0272107762695302	0.473323416706662	0.579987699665975	NA	NA	NA	NA	0.499444781916788	0.553866334455849	NA	NA	0.582720162147006	NA	NA	NA	NA	0.579012532913556	0.586427791380455	NA	NA	NA	NA	p.Gly231Tyr	0	34.2	-6.5	15.9	0.673	76.8	120.6	77.2	16.4	49.4845360824742	-2.4	0	0	23.76	0	0	0	0	6	22.3381463219125	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.887	-4.57	3.683	0.037822866	NA	NA	NA	NA	NA	NA	NA
I232A	232	I	A	missense	possibly_wt-like	0.850138897116251	0.202514282061052	4	0.101257141030526	0.651678547518928	1.04859924671357	NA	NA	NA	NA	1.00410306107304	0.69792304296863	1.04440564641388	0.654123838009457	0.635786389739612	NA	NA	NA	NA	0.652801006690268	0.614105654955272	0.700571260019034	0.618771772788956	NA	NA	p.Ile232Ala	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.175	-2.534	0.359	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232C	232	I	C	missense	possibly_low	0.703635713686402	0.0796303333840657	4	0.0398151666920328	0.625599420931559	0.781672006441245	NA	NA	NA	NA	0.624383255024938	0.729753377866295	0.803169651910614	0.65723656994376	0.619846551416547	NA	NA	NA	NA	0.597280377963194	0.620221272033669	0.650947791817483	0.619471830799426	NA	NA	p.Ile232Cys	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.175	-3.475	1.3	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232D	232	I	D	missense	low	0.500759186198428	0.161885663470084	4	0.080942831735042	0.34211415119106	0.659404221205796	NA	NA	NA	NA	0.436855390144787	0.354475261261528	0.481256130121017	0.730449963266379	0.577294794393852	NA	NA	NA	NA	0.56986104192605	0.548118440994185	0.584728546861653	0.635937631115998	NA	NA	p.Ile232Asp	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.175	-4.316	2.141	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232E	232	I	E	missense	possibly_low	0.630407391426457	0.219526974168014	4	0.109763487084007	0.415274909924275	0.845539872928638	NA	NA	NA	NA	0.792697122250685	0.312816448742322	0.759609332710195	0.656506662002625	0.620599008977929	NA	NA	NA	NA	0.621890344530687	0.540114461578724	0.641987213114697	0.619307673425171	NA	NA	p.Ile232Glu	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.175	-4.133	1.958	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232F	232	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile232Phe	1	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.175	-3.624	1.449	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232G	232	I	G	missense	possibly_low	0.673443215675373	0.331091636624937	7	0.125140875954707	0.428171605810353	0.918714825540392	0.233589100214252	NA	0.516630762160669	0.267742819726082	1.005312843701	0.858448071278401	0.996375833030667	0.836003079616533	0.644947605182861	0.523034604882431	NA	0.573104889455683	0.481809819826451	0.65297789472997	0.644947605182861	0.690691283682766	0.65967668291701	NA	NA	p.Ile232Gly	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.175	-3.09	0.915	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232H	232	I	H	missense	possibly_low	0.131112520447657	0.605215553610346	3	0.349421362794682	-0.553740766058823	0.815965806954137	NA	NA	NA	NA	-0.55326284464397	0.35079046430444	0.595809941682502	NA	0.547410474606975	NA	NA	NA	NA	0.425091172053501	0.547410474606975	0.608292847193753	NA	NA	NA	p.Ile232His	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.175	-3.502	1.327	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232K	232	I	K	missense	possibly_low	0.578217143209359	0.235026167197704	4	0.117513083598852	0.347895731643365	0.808538554775353	NA	NA	NA	NA	0.22928384114822	0.740083724741268	0.660355782458703	0.683145224489244	0.621888156774477	NA	NA	NA	NA	0.539511024037643	0.622206059374972	0.621570254173982	0.625298725481621	NA	NA	p.Ile232Lys	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.175	-4.101	1.926	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232L	232	I	L	missense	wt-like	0.946813876023158	0.0998927873450366	4	0.0499463936725183	0.848920743267363	1.04470700877895	NA	NA	NA	NA	1.09109486664574	0.931837048080117	0.865812268432068	0.898511320934708	0.664677092960772	NA	NA	NA	NA	0.665520490010788	0.659047955723865	0.663833695910756	0.673734878733036	NA	NA	p.Ile232Leu	1	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.175	-1.6	-0.575	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232M	232	I	M	missense	possibly_low	0.661351537710173	0.459082608322115	3	0.265051467495048	0.14186020737039	1.18084286804996	NA	NA	NA	NA	0.241893843400984	0.590370083526449	1.15179068620309	NA	0.593441319574845	NA	NA	NA	NA	0.541354792106024	0.593441319574845	0.722660907620233	NA	NA	NA	p.Ile232Met	1	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.175	-2.891	0.716	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232N	232	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile232Asn	1	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.175	-4.392	2.217	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232P	232	I	P	missense	possibly_low	0.637880041899042	0.152975684698829	4	0.0764878423494145	0.487966625639012	0.787793458159072	NA	NA	NA	NA	0.507861838110563	0.505524890619776	0.795164345914401	0.742969092951428	0.60949821619241	NA	NA	NA	NA	0.580243230508114	0.577139866497833	0.649301059751795	0.638753201876705	NA	NA	p.Ile232Pro	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.175	-4.411	2.236	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232Q	232	I	Q	missense	possibly_wt-like	0.962815109395547	0.259216799945964	4	0.129608399972982	0.708787313354641	1.21684290543645	NA	NA	NA	NA	1.04694175253744	0.833140543083776	1.28278425620029	0.688393885760685	0.649574940284052	NA	NA	NA	NA	0.659064654374865	0.640085226193239	0.749606949684762	0.626479157155427	NA	NA	p.Ile232Gln	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.175	-3.535	1.36	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232R	232	I	R	missense	possibly_low	0.69920113094112	0.0662438957770734	4	0.0331219478885367	0.634283305981776	0.764118955900465	NA	NA	NA	NA	0.661332247393842	0.641165606613572	0.790533970150334	0.703772699606734	0.616569313020102	NA	NA	NA	NA	0.602682864887707	0.603200750931644	0.648348567960665	0.629937875108561	NA	NA	p.Ile232Arg	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.175	-4.389	2.214	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232S	232	I	S	missense	possibly_wt-like	0.761574498440449	0.131853450836296	4	0.0659267254181479	0.632360491002218	0.890788505878681	NA	NA	NA	NA	0.956511524780117	0.72800887957601	0.678822770847048	0.682954818558622	0.625312455150608	NA	NA	NA	NA	0.645842423084715	0.619886098571887	0.625369007394679	0.625255902906537	NA	NA	p.Ile232Ser	1	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.175	-3.428	1.253	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232T	232	I	T	missense	possibly_low	0.702316046871189	0.111483772254293	4	0.0557418861271466	0.593063957631648	0.811568136110729	NA	NA	NA	NA	0.838183073024115	0.678610097593951	0.723611279894473	0.568859736972216	0.619468043004429	NA	NA	NA	NA	0.62854106051907	0.610395025489787	0.634582230981343	0.599595750504827	NA	NA	p.Ile232Thr	1	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.175	-3.058	0.883	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232V	232	I	V	missense	wt-like	0.841974662333113	0.0510134679036383	4	0.0255067339518191	0.791982382424302	0.891966942241923	NA	NA	NA	NA	0.774212649604029	0.863723464287706	0.83596564103213	0.893996894408585	0.651827634365027	NA	NA	NA	NA	0.619187642362708	0.645961175529723	0.657694093200331	0.672719577538138	NA	NA	p.Ile232Val	1	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.175	-1.765	-0.41	0.031170811	NA	NA	NA	NA	4.06e-06	NA	NA
I232W	232	I	W	missense	possibly_wt-like	0.835012641947027	0.20162031585059	4	0.100810157925295	0.637428363137654	1.0325969207564	NA	NA	NA	NA	1.0970005018277	0.626764716296936	0.873347842430239	0.742937507233228	0.652064949961425	NA	NA	NA	NA	0.666383980861444	0.600433883066518	0.665383801720831	0.63874609820202	NA	NA	p.Ile232Trp	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.175	-5.628	3.453	0.031170811	NA	NA	NA	NA	NA	NA	NA
I232X	232	I	X	nonsense	possibly_wt-like	0.734621305892103	0.308924402202851	4	0.154462201101426	0.431880954760526	1.03736165702368	NA	NA	NA	NA	0.604503916509479	0.517187320597059	1.19273728832465	0.62405669813722	0.603191677236477	NA	NA	NA	NA	0.594373725859519	0.579380589260379	0.731083831456806	0.612009628613435	NA	NA	p.Ile232Ter	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I232Y	232	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile232Tyr	0	36.5	-3.8	17.1	0.734	46.8	-165.3	-105.8	161.6	4.71204188481675	-1.6	0	0	22.5	0	0	0	0	7	22.1431273805233	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.175	-4.396	2.221	0.031170811	NA	NA	NA	NA	NA	NA	NA
D233A	233	D	A	missense	wt-like	1.25615787503575	0.157921931214476	4	0.0789609656072378	1.10139722626106	1.41091852381045	NA	NA	NA	NA	1.47106286417177	1.22012783484084	1.24201172557741	1.09142907555299	0.719099887366102	NA	NA	NA	NA	0.721077407987673	0.714437761226272	0.741219833238781	0.717122366744532	NA	NA	p.Asp233Ala	1	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.889	-2.731	0.842	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233C	233	D	C	missense	wt-like	1.33323942340443	0.0755427838265099	4	0.037771391913255	1.2592088556085	1.40726999120036	NA	NA	NA	NA	1.39359738851414	1.33990573271762	1.22493929834809	1.37451527403787	0.737579421706636	NA	NA	NA	NA	0.709750814418812	0.73745089508819	0.737707948325081	0.780788870987674	NA	NA	p.Asp233Cys	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.889	-4.152	2.263	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233E	233	D	E	missense	wt-like	1.31171546513387	0.139060109588467	4	0.0695300547942336	1.17543906189408	1.44799186837367	NA	NA	NA	NA	1.36337296990402	1.47309364652445	1.14771012245892	1.26268512164811	0.738729809729923	NA	NA	NA	NA	0.705331559227441	0.763040518412348	0.721821514951572	0.755638104508275	NA	NA	p.Asp233Glu	1	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.889	-2.329	0.44	0.033937134	NA	NA	NA	NA	4.06e-06	NA	NA
D233F	233	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp233Phe	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.889	-4.714	2.825	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233G	233	D	G	missense	wt-like	1.00414216782654	0.0624119870137402	4	0.0312059935068701	0.942979544451279	1.06530479120179	NA	NA	NA	NA	1.01756703326529	0.947996392158522	1.08649711099619	0.964508134886138	0.675365169013753	NA	NA	NA	NA	0.654769637742352	0.662152678339548	0.709229687873294	0.688577659687958	NA	NA	p.Asp233Gly	1	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.889	-2.907	1.018	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233H	233	D	H	missense	possibly_wt-like	1.52241480560745	0.587711465899886	2	0.415574762918896	0.707903237402641	2.33692637381225	NA	NA	NA	NA	1.93798956852634	1.10684004268855	NA	NA	0.741010276159469	NA	NA	NA	NA	0.789348969761153	0.692671582557786	NA	NA	NA	NA	p.Asp233His	1	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.889	-4.985	3.096	0.033937134	NA	NA	NA	NA	8.12e-06	NA	NA
D233I	233	D	I	missense	wt-like	0.877237010337882	0.150327293542862	4	0.0751636467714311	0.729918969719187	1.02455505095658	NA	NA	NA	NA	0.677339213242514	0.928168848120995	1.03582193899434	0.867618040993675	0.662565056291025	NA	NA	NA	NA	0.605023319069384	0.658343178146465	0.698805547845517	0.666786934435584	NA	NA	p.Asp233Ile	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.889	-3.743	1.854	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233K	233	D	K	missense	possibly_low	0.604693608369092	0.17788051097147	4	0.088940255485735	0.430373910841261	0.779013305896924	NA	NA	NA	NA	0.425107042399095	0.75704159601259	0.758120290863076	0.478505504201606	0.602369577235032	NA	NA	NA	NA	0.568143260438343	0.625464204395864	0.641680909650725	0.579274950074201	NA	NA	p.Asp233Lys	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.889	-2.676	0.787	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233L	233	D	L	missense	possibly_low	0.68881264585152	0.0641753124616526	4	0.0320876562308263	0.625921995290798	0.751703296412242	NA	NA	NA	NA	0.708274479249058	0.657647186708951	0.620715571112044	0.768613346336026	0.611481286084759	NA	NA	NA	NA	0.609546510620538	0.606367385308389	0.613416061548979	0.644520632347215	NA	NA	p.Asp233Leu	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.889	-3.917	2.028	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233M	233	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp233Met	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.889	-5.108	3.219	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233N	233	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp233Asn	1	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.889	-3.17	1.281	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233P	233	D	P	missense	possibly_low	0.713938046826623	0.0906945908895554	4	0.0453472954447777	0.625058980958561	0.802817112694684	NA	NA	NA	NA	0.830102537366317	0.618592096092537	0.672911939511054	0.734145614336584	0.625756343289244	NA	NA	NA	NA	0.62735956718365	0.598863663467574	0.624153119394837	0.636768788501281	NA	NA	p.Asp233Pro	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.889	-2.823	0.934	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233Q	233	D	Q	missense	wt-like	1.16577556998607	0.0987420382367183	4	0.0493710191183592	1.06901015063405	1.2625409893381	NA	NA	NA	NA	1.21829876983661	1.22968419153721	1.01916059990997	1.1959587186605	0.705826033175233	NA	NA	NA	NA	0.684119574307172	0.716273840501199	0.695378225849266	0.740631237901293	NA	NA	p.Asp233Gln	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.889	-3.019	1.13	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233R	233	D	R	missense	wt-like	1.24393523497187	0.182095621470611	4	0.0910478107353055	1.06548480505945	1.42238566488428	NA	NA	NA	NA	1.41563796410209	1.38694894789646	1.08961653292269	1.08353749496623	0.714160504914372	NA	NA	NA	NA	0.712973471216426	0.746489389062424	0.709871368792824	0.715347538612318	NA	NA	p.Asp233Arg	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.889	-3.436	1.547	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233S	233	D	S	missense	wt-like	1.13280611176041	0.195343179753838	4	0.0976715898769189	0.941373313288885	1.32423891023194	NA	NA	NA	NA	0.945971263477911	1.40672215653981	1.10860518927222	1.06992583775172	0.71303184427827	NA	NA	NA	NA	0.644301281629554	0.750288449702619	0.713777431760298	0.712286256796242	NA	NA	p.Asp233Ser	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.889	-2.189	0.3	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233T	233	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp233Thr	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.889	-1.989	0.1	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233V	233	D	V	missense	wt-like	0.813004698284312	0.0922700074915229	4	0.0461350037457614	0.722581752516	0.903427644052625	NA	NA	NA	NA	0.706151874292083	0.803309945683263	0.931436943257732	0.811120029904172	0.644217135201028	NA	NA	NA	NA	0.609236154510919	0.634353822125143	0.677333024529414	0.654080448276913	NA	NA	p.Asp233Val	1	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.889	-3.94	2.051	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233W	233	D	W	missense	wt-like	0.988291996025821	0.0666354496321558	4	0.0333177248160779	0.922990455339492	1.05359353671215	NA	NA	NA	NA	1.05211567741192	0.89794887397363	0.982396207117315	1.02070722560042	0.673818381047383	NA	NA	NA	NA	0.65982115840084	0.652536962453213	0.687815603693927	0.701216918212646	NA	NA	p.Asp233Trp	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.889	-5.826	3.937	0.033937134	NA	NA	NA	NA	NA	NA	NA
D233X	233	D	X	nonsense	possibly_wt-like	0.790349621957218	0.151463282550257	4	0.0757316412751284	0.641918332567859	0.938780911346577	NA	NA	NA	NA	0.922982231654927	0.653206112286732	0.665299431115222	0.919910712771991	0.631763567174429	NA	NA	NA	NA	0.640939946560092	0.605514114028955	0.622587187788767	0.678547633570612	NA	NA	p.Asp233Ter	0	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D233Y	233	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp233Tyr	1	38.7	-3.9	20.2	0.374	73.7	46.4	-128.4	-0.3	60.9625668449198	-0.9	0	0	21.72	0	0	0	0	3	24.4868536010855	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.889	-4.724	2.835	0.033937134	NA	NA	NA	NA	NA	NA	NA
C234A	234	C	A	missense	wt-like	1.29961744062781	0.210568014758049	4	0.105284007379025	1.09326457801687	1.50597030323875	NA	NA	NA	NA	1.47744526866314	1.48609990318619	1.12880309194322	1.10612149871869	0.721218661976792	NA	NA	NA	NA	0.722010609533937	0.765539432910805	0.717932242832321	0.720426714419647	NA	NA	p.Cys234Ala	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-3.555	-2.413	-1.142	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234D	234	C	D	missense	wt-like	1.6687597542308	0.0366336715270724	4	0.0183168357635362	1.63285941582353	1.70466009263806	NA	NA	NA	NA	1.70356394710621	1.67548985115086	1.67887061937248	1.61711459929363	0.816505587187311	NA	NA	NA	NA	0.755072490937364	0.801927249877642	0.831083924496981	0.835349817630236	NA	NA	p.Cys234Asp	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-3.555	-3.46	-0.095	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234E	234	C	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys234Glu	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-3.555	-2.877	-0.678	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234F	234	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys234Phe	1	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-3.555	-3.46	-0.095	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234G	234	C	G	missense	wt-like	0.960404840733229	0.0653003743783139	4	0.032650187189157	0.896411649753991	1.02439803171247	NA	NA	NA	NA	0.963558465036009	1.01010496182425	1.00074476404326	0.867211172029398	0.670390566914534	NA	NA	NA	NA	0.646872789548032	0.674085704824619	0.691589994961838	0.66669542900445	NA	NA	p.Cys234Gly	1	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-3.555	-2.923	-0.632	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234H	234	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys234His	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-3.555	-3.298	-0.257	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234I	234	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys234Ile	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-3.555	-3.788	0.233	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234K	234	C	K	missense	low	0.0848498049858669	0.0476001043425171	2	0.0336583565657811	0.0188806383381288	0.150818971633605	NA	NA	NA	NA	0.0511914484200858	0.118508161551648	NA	NA	0.508126484316212	NA	NA	NA	NA	0.513471293008911	0.502781675623513	NA	NA	NA	NA	p.Cys234Lys	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-3.555	-3.106	-0.449	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234L	234	C	L	missense	wt-like	1.10427862955804	0.123546841848929	4	0.0617734209244643	0.983204949344256	1.22535230977182	NA	NA	NA	NA	1.28744537049357	1.06358503568416	1.01827479479855	1.04780931725587	0.694712918530484	NA	NA	NA	NA	0.694229825818066	0.684360923546102	0.695196011242901	0.70731221866394	NA	NA	p.Cys234Leu	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-3.555	-3.853	0.298	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234M	234	C	M	missense	wt-like	1.26081752838624	0.317127539228031	4	0.158563769614016	0.950038250689861	1.57159680608262	NA	NA	NA	NA	1.37362815147068	1.57882133256662	0.827400639639596	1.26341998986806	0.731317197641373	NA	NA	NA	NA	0.706831017826183	0.78335416087001	0.655932228951491	0.755803377456563	NA	NA	p.Cys234Met	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-3.555	-5.068	1.513	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234N	234	C	N	missense	possibly_low	0.662398544838277	0.599711458282766	4	0.299855729141383	0.0746921151631685	1.25010497451338	NA	NA	NA	NA	0.174534979538244	1.42253508983918	0.190050227075612	0.862473882900075	0.598567969863885	NA	NA	NA	NA	0.531505934046914	0.753326615818561	0.524826014904791	0.665630005680857	NA	NA	p.Cys234Asn	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-3.555	-3.673	0.118	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234P	234	C	P	missense	possibly_wt-like	0.815967715914971	0.110067565253315	4	0.0550337826266573	0.708103484033716	0.923831947796225	NA	NA	NA	NA	0.913167568514791	0.713364888310984	0.728240062330869	0.909098344503239	0.637519646630405	NA	NA	NA	NA	0.639504898243925	0.617072523302755	0.635534395016886	0.676115915973833	NA	NA	p.Cys234Pro	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-3.555	-3.604	0.049	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234Q	234	C	Q	missense	wt-like	1.16643660473205	0.212400741561911	4	0.106200370780956	0.958287702856577	1.37458550660752	NA	NA	NA	NA	1.40885057269839	0.921316383099917	1.25859201189294	1.07698745123695	0.712927739359767	NA	NA	NA	NA	0.711981054618324	0.65702660223714	0.744630482269185	0.71387442410121	NA	NA	p.Cys234Gln	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-3.555	-3.299	-0.256	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234R	234	C	R	missense	wt-like	0.849577407722513	0.111651838295536	4	0.055825919147768	0.740160616789043	0.958994198655983	NA	NA	NA	NA	0.862645982541347	0.690941856182007	0.895273068853972	0.949448723312728	0.651005915135432	NA	NA	NA	NA	0.632117898216912	0.612764347511382	0.669893932053952	0.685190775777795	NA	NA	p.Cys234Arg	1	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-3.555	-2.115	-1.44	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234S	234	C	S	missense	wt-like	1.12548238230738	0.0287867319961512	4	0.0143933659980756	1.09727190333485	1.15369286127991	NA	NA	NA	NA	1.09344007127872	1.10919091379332	1.15324295071012	1.14605559344736	0.708041452635873	NA	NA	NA	NA	0.665863393471822	0.69312325947302	0.722959645798725	0.729407951318855	NA	NA	p.Cys234Ser	1	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-3.555	-2.247	-1.308	0.030689389	NA	NA	NA	NA	1.44e-05	NA	NA
C234T	234	C	T	missense	wt-like	0.997272709347844	0.206605041701343	4	0.103302520850671	0.79480348896833	1.19974192972736	NA	NA	NA	NA	0.953954758041868	0.776513397606493	1.27521783612462	0.98340484561839	0.669148071987742	NA	NA	NA	NA	0.645468586127687	0.629205355180412	0.748050498680021	0.692827557847796	NA	NA	p.Cys234Thr	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-3.555	-2.878	-0.677	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234V	234	C	V	missense	wt-like	1.27273081152164	0.268665539447763	4	0.134332769723881	1.00944342091932	1.53601820212396	NA	NA	NA	NA	1.56939675016827	1.41439409628638	1.13230023568557	0.974832163946327	0.727053446787707	NA	NA	NA	NA	0.735455270529324	0.751762472702674	0.718651623046091	0.690899549075306	NA	NA	p.Cys234Val	0	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-3.555	-3.427	-0.128	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234W	234	C	W	missense	wt-like	1.05156380175821	0.0676575594178049	4	0.0338287797089024	0.985260611887822	1.1178669916286	NA	NA	NA	NA	1.11132506978425	1.04510183624305	1.09086512494837	0.958963176057166	0.684070152425995	NA	NA	NA	NA	0.668478443690413	0.680809714596248	0.710128210508384	0.687330590255742	NA	NA	p.Cys234Trp	1	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-3.555	-2.937	-0.618	0.030689389	NA	NA	NA	NA	NA	NA	NA
C234X	234	C	X	nonsense	low	-0.312547996453395	0.303887765660766	4	0.151943882830383	-0.61035253447212	-0.0147434584346708	NA	NA	NA	NA	-0.566962414487102	-0.482773033286191	-0.316076282413899	0.115619744373611	0.421900658380022	NA	NA	NA	NA	0.423088093154623	0.387256483824838	0.420713223605421	0.497661406596916	NA	NA	p.Cys234Ter	1	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C234Y	234	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys234Tyr	1	39.7	-0.2	20.6	0.994	57.4	173.1	-138.1	143.5	52.027027027027	-0.8	0	0	18.63	0	0	0	0	4	23.4345192011716	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-3.555	-2.437	-1.118	0.030689389	NA	NA	NA	NA	NA	NA	NA
L235A	235	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu235Ala	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.597	-2.554	0.957	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235C	235	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu235Cys	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.597	-3.287	1.69	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235D	235	L	D	missense	wt-like	1.18555607664119	0.173008787143202	4	0.0865043935716009	1.01601058073638	1.35510157254601	NA	NA	NA	NA	1.22280984894672	1.11052630131972	1.00187890672455	1.40700924957379	0.692601561822724	NA	NA	NA	NA	0.684779160519009	0.693379829778955	0.691823293866492	0.788096814089127	NA	NA	p.Leu235Asp	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.597	-4.356	2.759	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235E	235	L	E	missense	low	0.145905536451506	0.452398271462548	4	0.226199135731274	-0.297436622915878	0.58924769581889	NA	NA	NA	NA	0.150897703497187	0.0689587921444892	0.732091028529384	-0.368325378365036	0.510655743022233	NA	NA	NA	NA	0.528049816124456	0.493261669920009	0.636326558305332	0.388821433559749	NA	NA	p.Leu235Glu	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.597	-4.199	2.602	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235F	235	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu235Phe	1	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.597	-2.003	0.406	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235G	235	L	G	missense	possibly_wt-like	0.885051666267276	0.184089086468343	4	0.0920445432341717	0.70464767655486	1.06545565597969	NA	NA	NA	NA	1.07085107319643	0.708127069708865	1.01441123724002	0.746817284923794	0.651089607581889	NA	NA	NA	NA	0.662560549227545	0.616066172191475	0.694401257847805	0.639618665936233	NA	NA	p.Leu235Gly	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.597	-3.09	1.493	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235H	235	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu235His	1	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.597	-5.138	3.541	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235I	235	L	I	missense	wt-like	1.22782619765502	0.420421456686736	4	0.210210728343368	0.815820740938091	1.63983165437196	NA	NA	NA	NA	1.37030647898383	1.11560185308053	0.714245644376037	1.7111508141797	0.700350172332253	NA	NA	NA	NA	0.706345340382031	0.694355004282475	0.632655672230053	0.856498701278032	NA	NA	p.Leu235Ile	1	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.597	-2.437	0.84	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235K	235	L	K	missense	possibly_low	0.681395662014433	0.253019558803418	4	0.126509779401709	0.433441050694977	0.92935027333389	NA	NA	NA	NA	0.529861656385294	0.489614014678666	0.66150569092532	1.04460128606845	0.602633362083441	NA	NA	NA	NA	0.583459927986201	0.574082882493406	0.621806796180681	0.706590727710658	NA	NA	p.Leu235Lys	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.597	-4.124	2.527	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235L	235	L	L	synonymous	possibly_wt-like	0.839124122060475	0.154967736740187	4	0.0774838683700936	0.687258530672249	0.9909897134487	NA	NA	NA	NA	0.947447053370375	0.689185659218554	0.995879804272112	0.723983971380858	0.6395002419191	NA	NA	NA	NA	0.64451706384948	0.612426926363372	0.690589248050074	0.63448341998872	NA	NA	p.Leu235=	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235M	235	L	M	missense	wt-like	1.26985017692173	0.0709110245690395	4	0.0354555122845198	1.20035864979065	1.33934170405281	NA	NA	NA	NA	1.34042538954847	1.32058027663181	1.21850416251662	1.19989087899002	0.735061035074101	NA	NA	NA	NA	0.701976284973078	0.733737861918225	0.736384208229978	0.741515586568391	NA	NA	p.Leu235Met	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.597	-2.806	1.209	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235N	235	L	N	missense	wt-like	0.959380400719672	0.123138374452222	4	0.0615691872261112	0.838707011199091	1.08005379024025	NA	NA	NA	NA	0.881460582324591	0.878744687653765	1.1395185481404	0.937797784759932	0.665708845768801	NA	NA	NA	NA	0.634868869834868	0.64884722905229	0.720136466546782	0.682570462485313	NA	NA	p.Leu235Asn	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.597	-4.443	2.846	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235P	235	L	P	missense	possibly_low	0.618234651639244	0.444342579084338	4	0.222171289542169	0.182786925737772	1.05368237754072	NA	NA	NA	NA	0.351457537942266	0.273521968623598	1.25212908511316	0.595830014877947	0.581518011957733	NA	NA	NA	NA	0.557374618066387	0.532564745420431	0.743301025434995	0.60566140584908	NA	NA	p.Leu235Pro	1	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.597	-4.485	2.888	0.041342151	NA	NA	NA	NA	1.22e-05	NA	NA
L235Q	235	L	Q	missense	wt-like	1.23105885789468	0.227333459268217	4	0.113666729634109	1.00827616157137	1.45384155421798	NA	NA	NA	NA	1.39888524687849	0.929509232488577	1.18172521005115	1.41411574216049	0.719671284137624	NA	NA	NA	NA	0.710523977199189	0.658600708504106	0.728818591076059	0.789695074770314	NA	NA	p.Leu235Gln	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.597	-3.779	2.182	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235R	235	L	R	missense	low	0.402926180712239	0.195133086652508	4	0.0975665433262538	0.211699269696715	0.594153091727763	NA	NA	NA	NA	0.191375221163023	0.597685692332849	0.286012862095922	0.536630947257162	0.56845673198461	NA	NA	NA	NA	0.533968225420794	0.594846880097508	0.544566015882973	0.592347448086246	NA	NA	p.Leu235Arg	1	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.597	-3.705	2.108	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235S	235	L	S	missense	wt-like	0.963063810036505	0.215309317757575	4	0.107654658878787	0.752064555866137	1.17406306420687	NA	NA	NA	NA	1.12636539602412	0.670128714848761	1.12325746332594	0.932503665947202	0.676028684133241	NA	NA	NA	NA	0.670677560923166	0.608765482811972	0.716791478884908	0.681379807343316	NA	NA	p.Leu235Ser	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.597	-3.913	2.316	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235T	235	L	T	missense	low	-0.11650166158672	0.50716969483568	4	0.25358484741784	-0.613518829550771	0.380515506377331	NA	NA	NA	NA	-0.63284924999764	-0.311200992096002	0.566395266764537	-0.0883516710177764	0.436004424807958	NA	NA	NA	NA	0.413454467322845	0.420220915667966	0.602242099300777	0.451787933947951	NA	NA	p.Leu235Thr	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.597	-3.085	1.488	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235V	235	L	V	missense	wt-like	0.98989997713492	0.168511200316507	4	0.0842556001582536	0.824762035328935	1.1550379189409	NA	NA	NA	NA	0.886422521663664	0.865743575405056	0.974959203940816	1.23247460753014	0.666317538680415	NA	NA	NA	NA	0.635594378453125	0.64634930295877	0.686285774402059	0.748843715253082	NA	NA	p.Leu235Val	1	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.597	-2.48	0.883	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235W	235	L	W	missense	possibly_low	0.648069261099358	0.369838657550598	4	0.184919328775299	0.285634036654452	1.01050448554427	NA	NA	NA	NA	0.38225091318244	0.500908482781091	1.19569686793165	0.513420780502256	0.581690177700839	NA	NA	NA	NA	0.561877063097518	0.576252908107044	0.731692632000108	0.587127447294635	NA	NA	p.Leu235Trp	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.597	-5.394	3.797	0.041342151	NA	NA	NA	NA	NA	NA	NA
L235X	235	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu235Ter	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L235Y	235	L	Y	missense	possibly_wt-like	0.826621580077718	0.343692904330044	3	0.198431190833515	0.437703592634634	1.2155395675208	NA	NA	NA	NA	0.515789931960009	0.76834936660723	NA	1.19572544166592	0.627636785840247	NA	NA	NA	NA	0.581402434605761	0.627636785840247	NA	0.74057877356059	NA	NA	p.Leu235Tyr	0	37.6	2.9	20.4	0.943	4.5	-176.2	-150	128.8	0.523560209424084	-4.3	0	0	15.28	0	0	0	0	7	20.2645592825839	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.597	-3.375	1.778	0.041342151	NA	NA	NA	NA	NA	NA	NA
F236A	236	F	A	missense	wt-like	1.3067170211698	0.0215386039718561	4	0.0107693019859281	1.28560957713875	1.32782446520085	NA	NA	NA	NA	1.32995728068112	1.31420097808853	1.30407549415679	1.27863433175276	0.74324943083623	NA	NA	NA	NA	0.700445693266663	0.732512196299408	0.753986665373051	0.759225105422616	NA	NA	p.Phe236Ala	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.726	-2.686	-0.04	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236C	236	F	C	missense	possibly_low	0.603557477851891	0.170242419692914	4	0.0851212098464571	0.436722972232359	0.770391983471424	NA	NA	NA	NA	0.526204709543909	0.399934730606717	0.740293552144104	0.747796919112835	0.610469543764452	NA	NA	NA	NA	0.582925228492992	0.556852647153061	0.638013859035911	0.639838987112564	NA	NA	p.Phe236Cys	1	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.726	-5.456	2.73	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236D	236	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236Asp	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.726	-2.625	-0.101	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236E	236	F	E	missense	wt-like	0.899404012665639	0.0701171722507873	4	0.0350585861253937	0.830690446510972	0.968117578820306	NA	NA	NA	NA	0.922717794595116	0.796785612514711	0.955343952364076	0.922768691188653	0.66004583955277	NA	NA	NA	NA	0.640901281966922	0.63310029075392	0.682250817616742	0.679190397138618	NA	NA	p.Phe236Glu	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.726	-2.604	-0.122	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236G	236	F	G	missense	wt-like	0.805736593606349	0.043779470023532	4	0.021889735011766	0.762833501352162	0.848639685860535	NA	NA	NA	NA	0.847409927525793	0.744449860571021	0.809848871855698	0.821237714472882	0.641105951903754	NA	NA	NA	NA	0.629890162554167	0.623044932573538	0.65232174125334	0.656355930483295	NA	NA	p.Phe236Gly	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.726	-3.283	0.557	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236H	236	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236His	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.726	-3.255	0.529	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236I	236	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236Ile	1	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.726	-3.041	0.315	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236K	236	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236Lys	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.726	-3.113	0.387	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236L	236	F	L	missense	possibly_low	0.696593806617969	0.359738131696747	4	0.179869065848374	0.344056915622294	1.04913069761365	NA	NA	NA	NA	0.733716513254136	0.528018452860426	1.18052996132202	0.344110299035298	0.597364052050791	NA	NA	NA	NA	0.613266510740518	0.581461593361064	0.728572722347286	0.549049269889952	NA	NA	p.Phe236Leu	1	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.726	-2.492	-0.234	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236M	236	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236Met	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.726	-3.958	1.232	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236N	236	F	N	missense	wt-like	1.73258994804908	0.165093696369335	3	0.0953168900403458	1.54577227645164	1.91940761964652	NA	NA	NA	NA	1.77220513361947	1.87427200318306	NA	1.55129270734471	0.820546376892093	NA	NA	NA	NA	0.765108843455951	0.840119607192036	NA	0.820546376892093	NA	NA	p.Phe236Asn	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.726	-3.054	0.328	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236P	236	F	P	missense	possibly_low	0.71451614297935	0.165991564234466	4	0.0829957821172328	0.55184739916084	0.877184886797859	NA	NA	NA	NA	0.819614248243024	0.485755754834742	0.70006985927559	0.852624709564043	0.627782833063803	NA	NA	NA	NA	0.625826024826572	0.573341588382922	0.629739641301034	0.663414912047377	NA	NA	p.Phe236Pro	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.726	-4.456	1.73	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236Q	236	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236Gln	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.726	-2.805	0.079	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236R	236	F	R	missense	wt-like	0.953285159187174	0.157360504305775	4	0.0786802521528875	0.799074698672984	1.10749561970136	NA	NA	NA	NA	1.17379795081454	0.956432117789398	0.859334719046435	0.823575849098321	0.663137339984838	NA	NA	NA	NA	0.677612899091336	0.663773448837337	0.662501231132339	0.656881780414688	NA	NA	p.Phe236Arg	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.726	-3.236	0.51	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236S	236	F	S	missense	wt-like	1.13842720280362	0.0354027787168168	2	0.025033544903508	1.08936235638738	1.18749204921986	NA	NA	NA	NA	1.16346074770713	1.11339365790011	NA	NA	0.685016093836788	NA	NA	NA	NA	0.6761014477352	0.693930739938376	NA	NA	NA	NA	p.Phe236Ser	1	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.726	-2.775	0.049	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236T	236	F	T	missense	possibly_wt-like	0.734165338756015	0.474722563761409	4	0.237361281880705	0.268945774945574	1.19938490256646	NA	NA	NA	NA	0.0925306427198878	0.715912008084041	1.21631015121813	0.911908553001998	0.647154920914719	NA	NA	NA	NA	0.5195156921212	0.617561905812707	0.73593288897255	0.676747936016731	NA	NA	p.Phe236Thr	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.726	-2.686	-0.04	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236V	236	F	V	missense	wt-like	1.27986880511095	0.0958629037601738	4	0.0479314518800869	1.18592488569926	1.37381272452263	NA	NA	NA	NA	1.23766050188903	1.41951757294527	1.25888345753082	1.20341368807867	0.743499152826248	NA	NA	NA	NA	0.686950544721865	0.752746855099422	0.744690434115814	0.742307871536682	NA	NA	p.Phe236Val	1	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.726	-2.668	-0.058	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236W	236	F	W	missense	wt-like	1.06536591807194	0.168675262425843	4	0.0843376312129213	0.900067198353194	1.23066463779069	NA	NA	NA	NA	1.01706481287024	1.04167369028023	1.30119775920526	0.901527409932036	0.677282130305456	NA	NA	NA	NA	0.654696205723141	0.680151059006701	0.753394700690692	0.674413201604211	NA	NA	p.Phe236Trp	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.726	-4.109	1.383	0.035831039	NA	NA	NA	NA	NA	NA	NA
F236X	236	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236Ter	0	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F236Y	236	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe236Tyr	1	38.5	6.5	21.1	0.929	12.4	-148.5	-121.3	148.7	30.7017543859649	-6	0	1	15.35	0	0	0	0	8	20.243543958711	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.726	-3.124	0.398	0.035831039	NA	NA	NA	NA	NA	NA	NA
E237A	237	E	A	missense	low	0.582283732467999	0.107283431473517	4	0.0536417157367584	0.477147901555017	0.687419563380981	NA	NA	NA	NA	0.572955778079302	0.480754631737464	0.54287188981768	0.732552630237551	0.593582072314045	NA	NA	NA	NA	0.589760923332726	0.572380713986746	0.597403221295365	0.636410524024089	NA	NA	p.Glu237Ala	1	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.243	-2.885	1.642	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237C	237	E	C	missense	possibly_low	0.683185995711015	0.376034996320044	4	0.188017498160022	0.314678470854046	1.05169352056798	NA	NA	NA	NA	0.292164228529806	0.762317197322466	1.16807604851705	0.510186508474734	0.606438934750761	NA	NA	NA	NA	0.548705062869491	0.626477814763873	0.726010889286948	0.586400054737648	NA	NA	p.Glu237Cys	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.243	-5.409	4.166	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237D	237	E	D	missense	possibly_low	0.593015663777331	0.435629805518579	4	0.217814902759289	0.16610629907303	1.01992502848163	NA	NA	NA	NA	0.506229306230307	0.0767013398073581	1.13262315455708	0.65650885451458	0.599656348412595	NA	NA	NA	NA	0.580004530300843	0.494749258940658	0.718718049096585	0.619308166524348	NA	NA	p.Glu237Asp	1	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.243	-2.76	1.517	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237E	237	E	E	synonymous	wt-like	0.844660176348973	0.102771160891981	4	0.0513855804459905	0.743946289350146	0.9453740633478	NA	NA	NA	NA	0.698879279079861	0.924322887381119	0.846883334910153	0.908555204024761	0.658772082658005	NA	NA	NA	NA	0.608172793969202	0.657604247084029	0.65993991823198	0.675993762877841	NA	NA	p.Glu237=	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237F	237	E	F	missense	wt-like	1.24957691051835	0.29026772935342	4	0.14513386467671	0.965119762814891	1.53403405822181	NA	NA	NA	NA	1.45413611527663	1.21851485201193	1.47500305970607	0.850653615078775	0.716365162016654	NA	NA	NA	NA	0.718602467976657	0.71412785605665	0.789147332964422	0.662971609985738	NA	NA	p.Glu237Phe	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.243	-3.141	1.898	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237G	237	E	G	missense	low	0.491296324283425	0.145072453621445	4	0.0725362268107225	0.34912793215998	0.63346471640687	NA	NA	NA	NA	0.557206791740317	0.274413389388743	0.553379008692628	0.580186107312011	0.593511389260363	NA	NA	NA	NA	0.587458189555274	0.5327360156277	0.599564588965453	0.60214306792672	NA	NA	p.Glu237Gly	1	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.243	-3.716	2.473	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237H	237	E	H	missense	possibly_wt-like	1.0583066206941	0.504907060441193	4	0.252453530220597	0.56350679369174	1.55310644769647	NA	NA	NA	NA	1.40377774539694	0.461399053966942	1.54286626604409	0.825183417368446	0.684241328720072	NA	NA	NA	NA	0.711239332546642	0.568661893485604	0.803107138874417	0.657243324893503	NA	NA	p.Glu237His	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.243	-4.706	3.463	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237I	237	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu237Ile	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.243	-3.473	2.23	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237K	237	E	K	missense	low	0.280072689638612	0.151460669088459	4	0.0757303345442296	0.131643961394753	0.428501417882472	NA	NA	NA	NA	0.213660934609493	0.496497489641789	0.14885749011452	0.261274844188646	0.533823089353006	NA	NA	NA	NA	0.537226724984081	0.575405416396318	0.516352459882736	0.530419453721932	NA	NA	p.Glu237Lys	1	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.243	-2.946	1.703	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237L	237	E	L	missense	possibly_wt-like	0.886657291451722	0.209557370350505	4	0.104778685175252	0.681294842160767	1.09201974074268	NA	NA	NA	NA	1.06628272235368	0.602967159450355	1.02109946233715	0.856279821665699	0.663064770601779	NA	NA	NA	NA	0.661892589044813	0.595861617473242	0.695777059689135	0.664236952158745	NA	NA	p.Glu237Leu	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.243	-3.718	2.475	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237M	237	E	M	missense	possibly_wt-like	0.864429797112528	0.365105445496759	4	0.182552722748379	0.506633035245978	1.22222655897908	NA	NA	NA	NA	1.13433975548648	0.440624378014765	1.20176342733501	0.680991627613857	0.648328954048861	NA	NA	NA	NA	0.671843529734889	0.564670419206124	0.732940554053638	0.624814378362833	NA	NA	p.Glu237Met	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.243	-4.912	3.669	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237N	237	E	N	missense	low	-0.00216109275389848	0.155323940438207	4	0.0776619702191036	-0.154375757351764	0.150053571843967	NA	NA	NA	NA	-0.190149969956447	-0.062218322969544	0.0853485739303938	0.158375347980003	0.490735988178375	NA	NA	NA	NA	0.478183622803866	0.468058384812727	0.503288353552885	0.507277205010945	NA	NA	p.Glu237Asn	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.243	-3.109	1.866	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237P	237	E	P	missense	possibly_low	0.498870520042734	0.287801071726222	4	0.143900535863111	0.216830652395023	0.780910387690446	NA	NA	NA	NA	0.287990576705406	0.26693543104304	0.558751632460628	0.881804439961863	0.574382289217214	NA	NA	NA	NA	0.548094813496959	0.531299262608369	0.600669764937469	0.66997747652113	NA	NA	p.Glu237Pro	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.243	-4.11	2.867	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237Q	237	E	Q	missense	wt-like	1.05757875626114	0.285350622260459	4	0.14267531113023	0.777940284962842	1.33721722755944	NA	NA	NA	NA	1.00772578835499	0.675820266774527	1.23526726383117	1.31150170608387	0.696581583006606	NA	NA	NA	NA	0.653330702779851	0.609859010488376	0.739832463233362	0.766617026464731	NA	NA	p.Glu237Gln	1	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.243	-2.532	1.289	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237R	237	E	R	missense	possibly_wt-like	0.722898384518574	0.241555105183144	4	0.120777552591572	0.4861787312982	0.959618037738947	NA	NA	NA	NA	0.982483878977156	0.419196169064082	0.829967918926581	0.659945571106476	0.634860526495522	NA	NA	NA	NA	0.64963996382811	0.560553380505791	0.656460331328271	0.620081089162935	NA	NA	p.Glu237Arg	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.243	-3.142	1.899	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237S	237	E	S	missense	wt-like	0.938941235332559	0.0842478782605996	4	0.0421239391302998	0.856379831750214	1.0215026389149	NA	NA	NA	NA	1.05082052066426	0.90442943429616	0.852339791528638	0.948175194841181	0.660347063227032	NA	NA	NA	NA	0.659631787407321	0.653782083672121	0.661062339046743	0.684904357343157	NA	NA	p.Glu237Ser	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.243	-3.554	2.311	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237T	237	E	T	missense	low	-0.214465104888825	0.292277089107588	3	0.168746256074226	-0.545201689320282	0.116271479542632	NA	NA	NA	NA	-0.439771166743871	-0.319421312473211	NA	0.115797164550606	0.441685327038153	NA	NA	NA	NA	0.441685327038153	0.418641531352646	NA	0.497701308656825	NA	NA	p.Glu237Thr	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.243	-2.398	1.155	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237V	237	E	V	missense	possibly_wt-like	0.728962038709799	0.0914477031073053	4	0.0457238515536527	0.639344936430184	0.818579140989414	NA	NA	NA	NA	0.804972578629913	0.596604721200676	0.747023408385576	0.767247446623029	0.631541710839774	NA	NA	NA	NA	0.623685197064664	0.594639191251681	0.639398224614885	0.644213439483916	NA	NA	p.Glu237Val	1	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.243	-3.249	2.006	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237W	237	E	W	missense	low	0.251976787415822	0.21456987902138	4	0.10728493951069	0.0417021698913113	0.462251404940332	NA	NA	NA	NA	0.0536129743630743	0.0862211678702172	0.384006059922726	0.484066947507269	0.539274534852009	NA	NA	NA	NA	0.513825355769642	0.4965783199063	0.564723713934376	0.580525726889577	NA	NA	p.Glu237Trp	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.243	-5.551	4.308	0.04574364	NA	NA	NA	NA	NA	NA	NA
E237X	237	E	X	nonsense	low	0.210398440102434	0.218788987060805	4	0.109394493530403	-0.00401082732415509	0.424807707529023	NA	NA	NA	NA	0.0622913008383944	-0.0148509642955357	0.421929170031593	0.372224253835285	0.535233197392511	NA	NA	NA	NA	0.515094254927742	0.477159157035093	0.572524690121475	0.555372139857279	NA	NA	p.Glu237Ter	1	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E237Y	237	E	Y	missense	low	0.530597448897209	0.110049407734437	2	0.0778166824745836	0.378079553850636	0.683115343943782	NA	NA	NA	NA	0.452780766422625	0.608414131371793	NA	NA	0.584548860041386	NA	NA	NA	NA	0.572189566510698	0.596908153572073	NA	NA	NA	NA	p.Glu237Tyr	0	36.3	9.6	21.1	0.94	9.3	-161.5	-116.3	139.3	8.41121495327103	-6.3	0	1	15.23	1	191	0	0	8	17.8101130415761	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.243	-3.557	2.314	0.04574364	NA	NA	NA	NA	NA	NA	NA
K238A	238	K	A	missense	wt-like	1.20019786758805	0.170324696502167	4	0.0851623482510833	1.03328273217707	1.36711300299903	NA	NA	NA	NA	1.39102380172739	1.29600314728518	1.0702910560107	1.04347346532894	0.707855798641575	NA	NA	NA	NA	0.709374518122942	0.729015815717534	0.705896020126483	0.706337079160208	NA	NA	p.Lys238Ala	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.344	-2.586	0.242	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238C	238	K	C	missense	wt-like	1.25564611998827	0.0813604497244027	4	0.0406802248622013	1.17591434437537	1.33537789560118	NA	NA	NA	NA	1.16758270796468	1.33142285598186	1.20572784511594	1.31785107089061	0.73478856013784	NA	NA	NA	NA	0.676704139039268	0.735821065367394	0.733756054908286	0.768045007989696	NA	NA	p.Lys238Cys	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.344	-4.283	1.939	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238D	238	K	D	missense	wt-like	1.1086619206637	0.237858939891879	4	0.118929469945939	0.875564442869216	1.34175939845818	NA	NA	NA	NA	1.27233909608118	1.06744532231502	0.788836094987435	1.30602716927115	0.68856183652888	NA	NA	NA	NA	0.692021065991108	0.685102607066652	0.647999306423929	0.765385795048003	NA	NA	p.Lys238Asp	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.344	-3.578	1.234	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238E	238	K	E	missense	wt-like	1.23716350640477	0.162305202250034	4	0.0811526011250172	1.07810733094799	1.39621968186155	NA	NA	NA	NA	1.40588900199175	1.05062993908407	1.15772925010912	1.33440583443414	0.717715264854508	NA	NA	NA	NA	0.711548029358558	0.681871838518423	0.723882500350457	0.771768198767027	rs150900439	*20	p.Lys238Glu	1	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.344	-2.671	0.327	0.036590473	1.130990415	0.0100000002660624	1	0.26	2.84e-05	NA	NA
K238F	238	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys238Phe	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.344	-4.643	2.299	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238G	238	K	G	missense	wt-like	0.943397604439327	0.0502007961932948	4	0.0251003980966474	0.894201728172281	0.992593480706374	NA	NA	NA	NA	0.934802884673846	0.947651443978197	1.00663756983359	0.884498519271681	0.666334890894647	NA	NA	NA	NA	0.642668300143766	0.662086402851416	0.692802175015466	0.670583378937877	NA	NA	p.Lys238Gly	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.344	-3.179	0.835	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238H	238	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys238His	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.344	-2.916	0.572	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238I	238	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys238Ile	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.344	-3.133	0.789	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238L	238	K	L	missense	possibly_low	0.385498900009118	0.576697455649719	4	0.288348727824859	-0.179654221515549	0.950652021533784	NA	NA	NA	NA	-0.213505901228546	1.0055100059423	0.0184156653139023	0.731575830008814	0.562855377407273	NA	NA	NA	NA	0.474768641630698	0.673202868035233	0.489519914604929	0.636190840209617	NA	NA	p.Lys238Leu	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.344	-3.079	0.735	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238M	238	K	M	missense	wt-like	1.3305750265029	0.163533356472469	4	0.0817666782362345	1.17031528202441	1.4908347709814	NA	NA	NA	NA	1.47467751009544	1.38777042080136	1.36396380484112	1.0958883702737	0.734126571265222	NA	NA	NA	NA	0.72160592246364	0.746647220066804	0.766305994779128	0.718125268714946	NA	NA	p.Lys238Met	1	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.344	-5.001	2.657	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238N	238	K	N	missense	wt-like	1.66245958223356	0.307150862752695	2	0.217188457899729	1.23677802689229	2.08814113757482	NA	NA	NA	NA	1.44527112433383	1.87964804013329	NA	NA	0.779229395078292	NA	NA	NA	NA	0.717306275723936	0.841152514432648	NA	NA	NA	NA	p.Lys238Asn	1	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.344	-2.631	0.287	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238P	238	K	P	missense	possibly_low	0.490749026721139	0.238186677002865	4	0.119093338501433	0.257330372459694	0.724167680982584	NA	NA	NA	NA	0.316832550608342	0.254539662923585	0.70106898076303	0.690554912589599	0.58963855509558	NA	NA	NA	NA	0.55231193490942	0.528917642325237	0.629945165660961	0.62696517528174	NA	NA	p.Lys238Pro	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.344	-3.588	1.244	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238Q	238	K	Q	missense	wt-like	1.28410196310834	0.133950555199746	4	0.066975277599873	1.15283283115801	1.41537109505866	NA	NA	NA	NA	1.18944138669243	1.33066125232788	1.45227580862065	1.16402940479238	0.734562512594217	NA	NA	NA	NA	0.67990019983667	0.73567473714533	0.784472222088585	0.733450288043104	NA	NA	p.Lys238Gln	1	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.344	-2.805	0.461	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238R	238	K	R	missense	wt-like	1.04614757968597	0.137717145440025	4	0.0688585727200124	0.911187257127914	1.18110790224403	NA	NA	NA	NA	1.19831542955387	1.11102788210385	0.882949112536618	0.992297894549543	0.687336957486158	NA	NA	NA	NA	0.681197715613227	0.693476199359089	0.667358831702569	0.694827617690134	NA	NA	p.Lys238Arg	1	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.344	-2.252	-0.092	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238S	238	K	S	missense	wt-like	0.925686383062354	0.141435978488979	4	0.0707179892444893	0.787081671084064	1.06429109504064	NA	NA	NA	NA	1.08869451260973	0.998763699718576	0.818420824954666	0.796866494966444	0.659627279199089	NA	NA	NA	NA	0.665169522894709	0.671906688598524	0.654085035503469	0.650874807212638	NA	NA	p.Lys238Ser	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.344	-2.671	0.327	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238T	238	K	T	missense	possibly_wt-like	0.787888283437054	0.132410908952736	4	0.066205454476368	0.658127977083266	0.917648589790841	NA	NA	NA	NA	0.765717894968018	0.691062532093804	0.713873894119526	0.980898812566866	0.625262392713654	NA	NA	NA	NA	0.617945584111436	0.612787533182206	0.632579201315872	0.69226394731234	NA	NA	p.Lys238Thr	1	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.344	-2.811	0.467	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238V	238	K	V	missense	wt-like	1.02901358031438	0.154910349653015	4	0.0774551748265076	0.877204227238173	1.18082293339059	NA	NA	NA	NA	1.22859580699679	1.05106102450995	0.977833628873995	0.85856386087679	0.683789908257066	NA	NA	NA	NA	0.685625152810198	0.681954663703934	0.686877058196847	0.664750635951536	NA	NA	p.Lys238Val	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.344	-2.602	0.258	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238W	238	K	W	missense	wt-like	0.982211037734039	0.129487396943587	4	0.0647436984717933	0.855315720503403	1.10910635496467	NA	NA	NA	NA	0.809527212334726	0.96392812638603	1.0467683472914	1.108620464924	0.683135474730672	NA	NA	NA	NA	0.624351151599784	0.665213669882473	0.701057279578871	0.72098873561095	NA	NA	p.Lys238Trp	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.344	-5.827	3.483	0.036590473	NA	NA	NA	NA	NA	NA	NA
K238X	238	K	X	nonsense	low	-0.246946832685242	0.282315157904382	4	0.141157578952191	-0.523610603576405	0.0297169382059209	NA	NA	NA	NA	-0.581585873446834	-0.205246812166651	-0.303549638555083	0.102594993427599	0.43193404629948	NA	NA	NA	NA	0.420949928058473	0.440578074786356	0.423290017812604	0.494732120867663	NA	NA	p.Lys238Ter	1	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K238Y	238	K	Y	missense	possibly_low	0.364252215456698	0.386033860970109	4	0.193016930485054	-0.0140540167004793	0.742558447613876	NA	NA	NA	NA	-0.174840509419217	0.582546340384305	0.355333377610326	0.693969653251379	0.575381864006216	NA	NA	NA	NA	0.480422091435106	0.591938130326887	0.558825597685545	0.627733155501179	NA	NA	p.Lys238Tyr	0	37.5	13	20.2	0.969	6	-152.9	-119.9	138.8	18.2608695652174	-5.6	0	1	14.42	0	0	0	0	7	18.7126121593552	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.344	-3.926	1.582	0.036590473	NA	NA	NA	NA	NA	NA	NA
L239A	239	L	A	missense	possibly_low	0.598492855277988	0.240047049403781	4	0.120023524701891	0.363251069564729	0.833734640991247	NA	NA	NA	NA	0.591366946116259	0.474083170628085	0.936921983643387	0.39159932072422	0.58177591097891	NA	NA	NA	NA	0.592452907287026	0.571098914670793	0.67846132517013	0.559729621023432	NA	NA	p.Leu239Ala	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.912	-2.024	0.112	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239C	239	L	C	missense	wt-like	0.863245226497383	0.056215747216169	4	0.0281078736080845	0.808154806543534	0.918335646451233	NA	NA	NA	NA	0.847356682690765	0.855657982516313	0.941672933344808	0.808293307437646	0.648928127420375	NA	NA	NA	NA	0.629882377375017	0.644411540622481	0.679438619632016	0.653444714218268	NA	NA	p.Leu239Cys	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.912	-3.459	1.547	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239D	239	L	D	missense	possibly_low	0.642718553981162	0.221111337409861	4	0.11055566870493	0.426033425032756	0.859403682929567	NA	NA	NA	NA	0.71272496845687	0.318718403488765	0.817345591204164	0.722085252774849	0.622126816532724	NA	NA	NA	NA	0.610197237696201	0.541248414311527	0.653863854464805	0.634056395369247	NA	NA	p.Leu239Asp	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.912	-3.598	1.686	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239E	239	L	E	missense	low	0.45202084891504	0.233898198441293	4	0.116949099220647	0.222804826418171	0.681236871411908	NA	NA	NA	NA	0.268111592590368	0.265829525119265	0.753578774735298	0.520563503215228	0.566961034698295	NA	NA	NA	NA	0.545188213211846	0.531086782998077	0.64074669673769	0.588733856184743	NA	NA	p.Leu239Glu	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.912	-4.099	2.187	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239F	239	L	F	missense	wt-like	1.37784998548914	0.294503135501887	4	0.147251567750943	1.08924221603024	1.66645775494805	NA	NA	NA	NA	1.75622611571863	1.22668169123891	1.44913014061316	1.07936199438588	0.739234720311174	NA	NA	NA	NA	0.762772475675906	0.715696964946443	0.783825142217009	0.714408462363321	NA	NA	p.Leu239Phe	1	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.912	-3.254	1.342	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239G	239	L	G	missense	low	0.442994480537728	0.197979789389174	4	0.0989898946945869	0.248977852102925	0.63701110897253	NA	NA	NA	NA	0.404184629208642	0.178600193758177	0.584323456221706	0.604869642962385	0.585507057150228	NA	NA	NA	NA	0.565084095453216	0.514327261292633	0.605930018847241	0.607694431559533	NA	NA	p.Leu239Gly	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.912	-3.03	1.118	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239H	239	L	H	missense	low	0.258136642107746	0.219086852180355	4	0.109543426090178	0.0434354722278726	0.472837811987619	NA	NA	NA	NA	-0.0267809115140688	0.328873433583545	0.233168814560396	0.497285231801112	0.538447622444986	NA	NA	NA	NA	0.50207058549267	0.543199517737832	0.533695727152139	0.583498538554664	NA	NA	p.Leu239His	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.912	-5.222	3.31	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239I	239	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu239Ile	1	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.912	-2.413	0.501	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239K	239	L	K	missense	low	0.326874172703522	0.180856845215025	4	0.0904284226075125	0.14963772121403	0.504110624193014	NA	NA	NA	NA	0.212348458541048	0.228697725694097	0.59563174445897	0.270818762119972	0.534800358307349	NA	NA	NA	NA	0.537034821650759	0.523952586407113	0.608256191120625	0.532565894963939	NA	NA	p.Leu239Lys	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.912	-4.091	2.179	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239L	239	L	L	synonymous	wt-like	1.21038990027222	0.197911081859755	4	0.0989555409298775	1.01644060397898	1.40433919656545	NA	NA	NA	NA	1.23790003524935	1.46969786903646	1.00226359235379	1.13169810444925	0.709040678242657	NA	NA	NA	NA	0.686985568027352	0.762388081833633	0.691902425652484	0.72617893083283	NA	NA	p.Leu239=	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239M	239	L	M	missense	possibly_wt-like	0.832264831739963	0.188005408648807	4	0.0940027043244036	0.648022916814764	1.01650674666516	NA	NA	NA	NA	1.067686294387	0.866024337563946	0.779055963492845	0.616292731516058	0.646195365011524	NA	NA	NA	NA	0.662097811949998	0.64640324627603	0.645987483747018	0.610263501050609	NA	NA	p.Leu239Met	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.912	-3.584	1.672	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239N	239	L	N	missense	possibly_low	0.633299205685933	0.308132483498575	4	0.154066241749288	0.331334920623888	0.935263490747978	NA	NA	NA	NA	0.831414101527868	0.592453831800478	0.894923297913958	0.214405591501427	0.610696505451593	NA	NA	NA	NA	0.627551337182753	0.593841673720433	0.669821982396707	0.519878489552521	NA	NA	p.Leu239Asn	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.912	-3.447	1.535	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239P	239	L	P	missense	low	0.568073057423019	0.0731617404761528	4	0.0365808702380764	0.496375869233256	0.639770245612782	NA	NA	NA	NA	0.490924914114114	0.584581141048859	0.661618713193868	0.535167461335232	0.592173694012168	NA	NA	NA	NA	0.577766802747413	0.592329080083944	0.621830045434843	0.592018307940393	NA	NA	p.Leu239Pro	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.912	-4.361	2.449	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239Q	239	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu239Gln	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.912	-4.519	2.607	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239R	239	L	R	missense	possibly_low	0.65493953346262	0.143843803383474	4	0.0719219016917371	0.513975196447185	0.795903870478056	NA	NA	NA	NA	0.5564687840768	0.510848677648125	0.809359360964206	0.743081311161352	0.61306436094114	NA	NA	NA	NA	0.587350281964384	0.578162734870942	0.652221046378977	0.638778439917897	NA	NA	p.Leu239Arg	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.912	-4.405	2.493	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239S	239	L	S	missense	possibly_wt-like	0.746672889192503	0.0792760895664177	4	0.0396380447832088	0.668983748999828	0.824362029385179	NA	NA	NA	NA	0.863055645107087	0.685274498015621	0.722905397055124	0.715456016592182	0.632371633638264	NA	NA	NA	NA	0.632177796918148	0.611675468223647	0.634437027299344	0.632565470358379	NA	NA	p.Leu239Ser	1	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.912	-3.361	1.449	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239T	239	L	T	missense	possibly_wt-like	0.774315733476792	0.169609028955728	4	0.0848045144778642	0.608101939373773	0.940529527579812	NA	NA	NA	NA	0.798787818745509	0.528568979715866	0.905325582421803	0.864580553023991	0.644442346487529	NA	NA	NA	NA	0.622780894071144	0.581567367034199	0.671961785105509	0.666103798903914	NA	NA	p.Leu239Thr	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.912	-2.639	0.727	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239V	239	L	V	missense	wt-like	0.935794277004482	0.152329321465367	4	0.0761646607326833	0.786514285073711	1.08507426893525	NA	NA	NA	NA	0.943642786406485	0.806488278705263	1.14727955602738	0.845766486878802	0.652916655809104	NA	NA	NA	NA	0.643960823984409	0.634964480724013	0.72173294525173	0.661872487633798	NA	NA	p.Leu239Val	1	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.912	-1.628	-0.284	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239W	239	L	W	missense	possibly_low	0.711394321631923	0.0930111618896007	4	0.0465055809448003	0.620245057900002	0.802543585363843	NA	NA	NA	NA	0.817173781279376	0.59115294679181	0.728659543174677	0.708591015281826	0.628245357015813	NA	NA	NA	NA	0.625469192609628	0.593591732442667	0.635620684355078	0.631021521421998	NA	NA	p.Leu239Trp	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.912	-5.653	3.741	0.034492032	NA	NA	NA	NA	NA	NA	NA
L239X	239	L	X	nonsense	low	0.582002119917823	0.1026930575286	4	0.0513465287642999	0.481364772808645	0.682639467027	NA	NA	NA	NA	0.609093438977277	0.664860874472417	0.432175699159034	0.621878467062562	0.601399072605587	NA	NA	NA	NA	0.595044781645682	0.607753363565492	0.57463245315816	0.611519741226838	NA	NA	p.Leu239Ter	1	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L239Y	239	L	Y	missense	possibly_low	0.40540456823623	0.483332334479472	4	0.241666167239736	-0.0682524158354854	0.879061552307946	NA	NA	NA	NA	-0.177975958125345	0.23368666072005	0.631422046027553	0.934485524322663	0.570264778428188	NA	NA	NA	NA	0.479963642650679	0.524911119088149	0.615618437768227	0.681825530219761	NA	NA	p.Leu239Tyr	0	35.8	16.3	21	0.945	17.3	-170.5	-111	121.1	0	-5.6	0	1	12.9	0	0	0	0	8	18.1830940263724	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.912	-4.437	2.525	0.034492032	NA	NA	NA	NA	NA	NA	NA
Y240A	240	Y	A	missense	low	0.0030959764250293	0.404161623182602	4	0.202080811591301	-0.392975136260545	0.399167089110604	NA	NA	NA	NA	-0.29969753020841	-0.381876151838198	0.264390594082211	0.429566993664514	0.501142180773191	NA	NA	NA	NA	0.462166155914252	0.406641975473734	0.540118205632131	0.568268606757435	NA	NA	p.Tyr240Ala	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.502	-3.265	1.763	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240C	240	Y	C	missense	possibly_low	0.599762168497979	0.458769112909024	8	0.162199375368454	0.281857234460917	0.917667102535042	0.536355671923636	0.621186487486337	1.02731090112169	1.48947048285658	0.132356106989784	0.134997654755477	0.404856797269594	0.451563245580736	0.58036955425911	0.587523512209713	0.59163544381016	0.725908048740996	0.886450753023486	0.52533876160663	0.505949830359416	0.56901281641198	0.573215596308506	rs1142345	*3C	p.Tyr240Cys	1	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.502	-4.006	2.504	0.03742489	0.646964856	0.0749999998741476	1.1	0.52	0.03708	10.555	0.688002924
Y240D	240	Y	D	missense	low	-0.0894663214778875	0.11000711079651	8	0.038893387011476	-0.165695959257158	-0.0132366836986167	-0.0385078478660107	-0.0682811060282808	-0.301689380046842	-0.0859596139623266	0.093040459256331	-0.0872712834832343	-0.146262359775903	-0.0807994399168339	0.454565625539166	0.465078289660064	0.442564435364357	0.328251225691682	0.364662204068116	0.51959023480817	0.463244916350189	0.455644809198851	0.453486441879481	NA	NA	p.Tyr240Asp	1	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.502	-3.59	2.088	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240E	240	Y	E	missense	low	0.175401058309863	0.269222355909489	6	0.109909566554703	-0.0400177336937624	0.390819850313488	-0.108876810546968	-0.0754556736173375	0.305201758271001	0.586608717038011	NA	NA	0.0445908687931258	0.300337489921346	0.502373223108908	0.450089787173055	0.441013209410123	0.509842159433292	0.587419439831615	NA	NA	0.494904286784524	0.539204700454552	NA	NA	p.Tyr240Glu	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.502	-4.07	2.568	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240F	240	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240Phe	1	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.502	-1.977	0.475	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240G	240	Y	G	missense	low	0.0876264742239985	0.2542586435759	8	0.089894005523906	-0.088562539028902	0.263815487476899	0.351453033643552	0.0522823987570362	0.162446694236685	0.324414014080126	-0.288232946521542	-0.302790026011452	0.219913260501126	0.181525365106457	0.484605611467476	0.548139477713131	0.46863168407795	0.467127702527252	0.500579538857002	0.463842446916856	0.421836929071465	0.530968992417928	0.512483678062258	NA	NA	p.Tyr240Gly	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.502	-3.907	2.405	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240H	240	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240His	1	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.502	-2.741	1.239	0.03742489	NA	NA	NA	NA	4.06e-06	NA	NA
Y240I	240	Y	I	missense	wt-like	1.02372305966182	0.14845166148346	4	0.0742258307417302	0.878243104685464	1.16920301463818	NA	NA	NA	NA	1.19596964269516	1.07238993485595	0.982818322865944	0.843714338230229	0.683453675507251	NA	NA	NA	NA	0.680854727022217	0.686052623992285	0.687902435045411	0.66141095637109	NA	NA	p.Tyr240Ile	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.502	-3.469	1.967	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240K	240	Y	K	missense	low	0.0831950568089687	0.211680397758305	4	0.105840198879152	-0.124247921110726	0.290638034728664	NA	NA	NA	NA	-0.118739971429491	-0.0666640061570323	0.190861842630658	0.32732236219174	0.506808892382506	NA	NA	NA	NA	0.488624816422072	0.467204228043282	0.52499296834294	0.545273638092978	NA	NA	p.Tyr240Lys	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.502	-4.09	2.588	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240L	240	Y	L	missense	wt-like	1.0000435410554	0.236459210304426	6	0.0965340683712168	0.81084024376669	1.18924683834411	0.747697517265065	0.832437828119198	NA	NA	1.35214167714825	1.21974159786472	0.968987207117974	0.879255418817198	0.677230751125607	0.6325390652863	0.637310469989618	NA	NA	0.703689378795223	0.714363552850676	0.685057304351194	0.66940419790002	NA	NA	p.Tyr240Leu	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.502	-2.918	1.416	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240M	240	Y	M	missense	possibly_wt-like	0.82435650529349	0.328577169450094	4	0.164288584725047	0.50235679616134	1.14635621442564	NA	NA	NA	NA	0.363617949042369	0.917584145926863	0.875098200453571	1.14112572575116	0.661026690163894	NA	NA	NA	NA	0.559152649285996	0.656309521079511	0.665743859248278	0.728299216791074	NA	NA	p.Tyr240Met	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.502	-4.851	3.349	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240N	240	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240Asn	1	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.502	-3.614	2.112	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240P	240	Y	P	missense	low	0.0203801972935166	0.242943282927651	8	0.085893421400932	-0.147967815161232	0.188728209748265	-0.311951573230455	-0.188024583475155	0.258840309511105	0.0855276193669555	-0.290050280151259	0.171923574309656	0.232859639716928	0.203916872300357	0.479773422188823	0.406835112532898	0.416674486212694	0.495970118405871	0.421459439834993	0.463576725971776	0.513044470896095	0.533632128317956	0.517519561109191	NA	NA	p.Tyr240Pro	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.502	-4.54	3.038	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240Q	240	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240Gln	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.502	-4.421	2.919	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240R	240	Y	R	missense	low	-0.0366698238382083	0.170987000160802	8	0.0604530336542241	-0.155155592556675	0.0818159448802588	0.0686190091704314	0.179832959154256	-0.0818127295842705	-0.0433555508650235	-0.299942923092241	-0.233126978322093	0.154909619148861	-0.038481996315587	0.46256698666059	0.487896178427247	0.496209616449383	0.394041618308298	0.378772834751148	0.462130275860121	0.435221410433407	0.517597413536131	0.463003697461058	NA	NA	p.Tyr240Arg	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.502	-3.254	1.752	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240S	240	Y	S	missense	low	0.169018792686225	0.142272891624325	8	0.0503010632232895	0.0704305203845052	0.267607064987945	0.0849296288017406	0.094513424094981	0.0586431355750676	0.0731450965452541	0.108806200111933	0.142373500549208	0.368969209711719	0.420770146099896	0.499368642331256	0.491370320344287	0.477762528796461	0.43606812041618	0.417358300324844	0.521895418342738	0.507366964318226	0.561630557542711	0.566290182744549	rs1142345 	*41	p.Tyr240Ser	1	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.502	-3.272	1.77	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240T	240	Y	T	missense	low	0.267242378328405	0.335915166142939	8	0.118763945941539	0.0344693216211269	0.500015435035683	-0.409376705216161	0.441141728625759	0.14284641367371	0.028350958130348	0.602246595262738	0.377186412377754	0.387454714332242	0.568088909440851	0.552594810740214	0.386083679266992	0.552707647897503	0.461263004520797	0.402522308215505	0.594043672244033	0.552481973582924	0.565433119646326	0.599422390254278	NA	NA	p.Tyr240Thr	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.502	-3.998	2.496	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240V	240	Y	V	missense	possibly_low	0.385719153429264	0.504650902463098	8	0.178421037631784	0.0360203455867016	0.735417961271826	0.978826946159847	1.01708251291059	0.264888770849856	0.738676944428064	-0.491036539079965	0.282888614746229	0.140619083501251	0.153806893918237	0.524511076556639	0.681769349318153	0.677232824027606	0.497779908783183	0.637785025630876	0.43418957448932	0.534364375276008	0.514657777837269	0.506249752943466	NA	NA	p.Tyr240Val	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.502	-3.18	1.678	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240W	240	Y	W	missense	possibly_wt-like	0.767968525433278	0.239577073024947	7	0.0905516221509672	0.590490607275703	0.945446443590853	0.86276717729597	0.665768392799044	1.14676399434535	NA	0.777591611869914	0.364836749787427	0.682555615234514	0.875496136700723	0.626136872427193	0.657048761320504	0.60127457644803	0.761650206382204	NA	0.619681696416405	0.55010921163453	0.626136872427193	0.668558729798428	NA	NA	p.Tyr240Trp	0	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.502	-2.29	0.788	0.03742489	NA	NA	NA	NA	NA	NA	NA
Y240X	240	Y	X	nonsense	low	-0.0243303076951588	0.172777649966229	4	0.0863888249831147	-0.193649293328798	0.14498867793848	NA	NA	NA	NA	-0.252520638388733	-0.0601291916716743	0.133729689877582	0.0815989094021901	0.479537091471548	NA	NA	NA	NA	0.469064112390311	0.468459773207959	0.513240594609218	0.490010070552785	NA	NA	p.Tyr240Ter	1	36.5	19.2	18.6	0.837	16	-152.4	-109.7	148.3	0.784313725490196	-6.5	0	1	12.61	1	39	0	0	8	19.1429217682789	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L241A	241	L	A	missense	wt-like	1.08136163059816	0.333440070596034	6	0.136126338792981	0.814558909216623	1.3481643519797	1.18233937203994	1.29504150296669	1.08998508970031	1.48664283990309	NA	NA	0.52956103839722	0.904599940581723	0.731224037406315	0.725117245680798	0.737330829131833	0.744661106261387	0.885514226727176	NA	NA	0.594665111613355	0.675104218286382	NA	NA	p.Leu241Ala	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.65	-3.23	1.58	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241C	241	L	C	missense	wt-like	1.08321080120916	0.230258619674678	6	0.094002687846756	0.898968918579557	1.26745268383876	0.764968727526842	1.06820959490652	1.30575085555959	0.871769622811399	NA	NA	1.33774997542163	1.15081603102897	0.709382840830892	0.636217811825964	0.688287100898218	0.809221460529304	0.681865836115866	NA	NA	0.760913677047618	0.730478580763566	NA	NA	p.Leu241Cys	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.65	-3.388	1.738	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241D	241	L	D	missense	possibly_low	0.410622421679338	0.342393940319604	4	0.171196970159802	0.0750825259037471	0.746162317454928	NA	NA	NA	NA	0.139421049074724	0.111270741513604	0.809419486226772	0.582378409902251	0.564503940110235	NA	NA	NA	NA	0.526371760202512	0.501391137643611	0.652233414450588	0.602636120017959	NA	NA	p.Leu241Asp	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.65	-4.278	2.628	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241E	241	L	E	missense	wt-like	1.07042638446487	0.152088014890763	6	0.0620896720791965	0.948732863377744	1.192119905552	0.9226899022845	0.939067691083269	0.993422357658601	1.23057625069842	NA	NA	1.28197256284245	1.05482954222199	0.712329582869279	0.669812228029414	0.66036510134867	0.715768088108745	0.800703980758889	NA	NA	0.749439980242184	0.708891077629814	NA	NA	p.Leu241Glu	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.65	-3.979	2.329	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241F	241	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu241Phe	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.65	-3.32	1.67	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241G	241	L	G	missense	low	0.48523118556538	0.111022181587677	6	0.0453246158367377	0.39639657091226	0.5740658002185	0.532753497319709	0.635804949981142	0.538700061107561	0.492151607148227	NA	NA	0.369856418502938	0.342120579332703	0.570760707849148	0.586756253450274	0.59479612745436	0.579708354805163	0.556134879248808	NA	NA	0.561813060893133	0.548601778989421	NA	NA	p.Leu241Gly	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.65	-3.302	1.652	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241H	241	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu241His	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.65	-3.172	1.522	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241I	241	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu241Ile	1	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.65	-2.887	1.237	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241K	241	L	K	missense	wt-like	1.07220986796696	0.130806239045497	6	0.0534014234723315	0.967545001238017	1.1768747346959	1.02398847419909	0.948906543928152	1.15706995126773	1.10411407955523	NA	NA	1.27032947721707	0.928850681634494	0.71921681884122	0.691388699235279	0.66249237713267	0.764733903313126	0.758819219948625	NA	NA	0.747044938447161	0.680558245774825	NA	NA	p.Leu241Lys	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.65	-2.743	1.093	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241L	241	L	L	synonymous	possibly_low	0.566759120540382	0.37223267862012	6	0.151963354701448	0.268916418355657	0.864601822725106	0.917763938227082	1.06620224098663	0.246370045259354	0.122372942079521	NA	NA	0.433535049721653	0.614310506968048	0.59236488714411	0.668763003744834	0.687853087355072	0.492238828251006	0.433662753401747	NA	NA	0.574912078466803	0.609817695821417	NA	NA	p.Leu241=	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241M	241	L	M	missense	possibly_low	0.592244022839333	0.316500705242116	6	0.129210871845701	0.338995367610739	0.845492678067928	0.967014565640785	0.463918757313947	0.459177314563473	1.000157448521	NA	NA	0.441074883800742	0.222121167196053	0.56704768508628	0.679253326798535	0.55763230957542	0.555913955963447	0.724388381175666	NA	NA	0.57646306059714	0.52161373392448	NA	NA	p.Leu241Met	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.65	-3.668	2.018	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241N	241	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu241Asn	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.65	-4.26	2.61	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241P	241	L	P	missense	low	-0.304745939858234	0.174943340169984	6	0.0714203195524342	-0.444727193945346	-0.164764685771121	-0.0426214634557106	-0.222362199448573	-0.255911916484602	-0.311040577880053	NA	NA	-0.488214094296683	-0.50832538758378	0.371319413433035	0.464202094599802	0.409250289500723	0.341948529586464	0.290114517187404	NA	NA	0.385303602201953	0.357335224664117	NA	NA	p.Leu241Pro	1	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.65	-4.446	2.796	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241Q	241	L	Q	missense	wt-like	0.9558405038637	0.197514016221368	6	0.080634759465025	0.7977992794102	1.1138817283172	0.933543952279485	1.15526253274886	1.10814355452218	1.0783339882841	NA	NA	0.644805924808291	0.814953070539275	0.689616548980255	0.672124127326289	0.707108970634221	0.750094391366616	0.750280753885636	NA	NA	0.618371569548817	0.654942504778308	NA	NA	p.Leu241Gln	1	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.65	-2.893	1.243	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241R	241	L	R	missense	possibly_low	0.58240329090922	0.226224223233598	6	0.0923556523966318	0.401389538443121	0.763417043375318	0.738758785164477	0.901020112491807	0.460648136904315	0.298154990108371	NA	NA	0.674258700463653	0.421579020322696	0.595451127354512	0.630635126344812	0.652138767054062	0.556354048074499	0.491882448428888	NA	NA	0.624430154956815	0.566472099752208	NA	NA	p.Leu241Arg	1	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.65	-2.098	0.448	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241S	241	L	S	missense	wt-like	0.950651056773776	0.190426692958459	8	0.0673260029549275	0.818694515759081	1.08260759778847	1.05635134352183	1.14422586024859	1.28068739213598	0.849408058765734	0.873575384518308	0.710610178641872	0.855367409405153	0.834982826952746	0.668072367457808	0.698281950589998	0.704722712142919	0.801722096247091	0.674459599508276	0.633715937770569	0.616543256188456	0.661685135407341	0.659447226585702	NA	NA	p.Leu241Ser	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.65	-3.926	2.276	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241T	241	L	T	missense	wt-like	1.22413575245021	0.155573535852564	4	0.0777867679262821	1.07167648884092	1.3765950160595	1.21873260799985	1.15172528943582	NA	NA	NA	NA	1.44235991074672	1.08372520161845	0.7241293571435	0.732868960171298	0.706344176998155	NA	NA	NA	NA	0.782432471578507	0.715389754115702	NA	NA	p.Leu241Thr	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.65	-3.154	1.504	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241V	241	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu241Val	1	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.65	-2.682	1.032	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241W	241	L	W	missense	possibly_low	0.494917028218447	0.377928170368922	6	0.154288529471248	0.192517067227154	0.797316989209739	1.00518872379129	0.820943559599342	0.46820721547031	-0.0325784470179597	NA	NA	0.473714006040958	0.234027111426743	0.570896465728206	0.687384375524838	0.63482527385318	0.558615837789917	0.382342253279876	NA	NA	0.583177093666496	0.524291398370641	NA	NA	p.Leu241Trp	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.65	-3.404	1.754	0.043708673	NA	NA	NA	NA	NA	NA	NA
L241X	241	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu241Ter	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L241Y	241	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu241Tyr	0	35.6	22.8	18.9	0.989	15.9	-170.7	-118.9	117.5	3.1413612565445	-5.5	0	1	12.96	0	0	0	0	6	20.3715652812508	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.65	-3.501	1.851	0.043708673	NA	NA	NA	NA	NA	NA	NA
L242A	242	L	A	missense	low	0.473478415422616	0.246098427601216	6	0.100469262354041	0.27656227965539	0.670394551189843	0.743980532440484	0.814333715777412	0.368055609674113	0.371072265267181	NA	NA	0.343997834563748	0.199430534812759	0.542571396862912	0.631747352091095	0.633396147823947	0.528648974766242	0.516032932335295	NA	NA	0.556493818959582	0.516510577180554	NA	NA	p.Leu242Ala	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.139	-3.419	2.28	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242C	242	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu242Cys	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.139	-3.746	2.607	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242D	242	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu242Asp	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.139	-4.384	3.245	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242E	242	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu242Glu	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.139	-4.215	3.076	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242F	242	L	F	missense	possibly_wt-like	0.871261874193419	0.366798199147452	5	0.164037141463641	0.54975498479778	1.19276876358906	1.2203207951695	1.23001088058947	0.746642999109578	0.805539099610303	NA	NA	NA	0.353795596488245	0.659930030352453	0.733207242084733	0.723270443192279	0.6419280016127	0.659930030352453	NA	NA	NA	0.551227507595232	NA	NA	p.Leu242Phe	1	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.139	-2.962	1.823	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242G	242	L	G	missense	low	0.448535128660443	0.133243957490611	6	0.0543966178601815	0.341919716773699	0.555150540547186	0.560811125567006	0.657048512718079	0.380524897249772	0.43119514994301	NA	NA	0.326116489836659	0.33551459664813	0.549965809668216	0.592732493751994	0.599389235745402	0.532379972684967	0.535945864567171	NA	NA	0.552815535611806	0.547116083724627	NA	NA	p.Leu242Gly	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.139	-4.107	2.968	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242H	242	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu242His	1	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.139	-5.222	4.083	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242I	242	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu242Ile	1	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.139	-1.714	0.575	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242K	242	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu242Lys	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.139	-4.101	2.962	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242L	242	L	L	synonymous	wt-like	1.19821644505308	0.148763616582502	6	0.0607324921530279	1.07918294774179	1.31724994236438	1.0736914230859	0.977022260098043	1.20793421286566	1.24243914650293	NA	NA	1.37240971228692	1.31580191547905	0.767813755354605	0.70197536620633	0.668571325878116	0.779953253497161	0.804633017788676	NA	NA	0.768043360798794	0.767584149910415	NA	NA	p.Leu242=	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242M	242	L	M	missense	possibly_wt-like	0.763500505421263	0.327662688786869	6	0.133767732546032	0.501320567337454	1.02568044350507	0.936056614566667	0.972469102497211	0.820907478817523	1.12754233363998	NA	NA	0.41283432960426	0.311193173401934	0.665867963871851	0.67265932130252	0.66758687961617	0.664149048127533	0.766578748427944	NA	NA	0.570653835294553	0.541646159706463	NA	NA	p.Leu242Met	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.139	-2.935	1.796	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242N	242	L	N	missense	low	-0.0444316789904522	0.522084356888592	6	0.213140046177693	-0.462178493161935	0.37331513518103	-0.0328462070115296	0.980715731063695	-0.260110788916508	-0.153703833640539	NA	NA	-0.403824295966702	-0.396820679471129	0.392537905096171	0.466284212197429	0.669369897771406	0.340692163959368	0.342225056169658	NA	NA	0.402663011947526	0.382412798244815	NA	NA	p.Leu242Asn	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.139	-4.472	3.333	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242P	242	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu242Pro	1	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.139	-4.435	3.296	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242Q	242	L	Q	missense	low	-0.0312173720656084	0.163397478633353	6	0.0667067413181721	-0.161960182575256	0.0995254384440389	-0.0860193963917601	0.0790348629291153	0.0164610790174523	0.197334369524172	NA	NA	-0.130650553530063	-0.263464593942567	0.456724328365715	0.454958388270178	0.474415881696597	0.42344661623889	0.458490268461251	NA	NA	0.458856236964448	0.412404778887441	NA	NA	p.Leu242Gln	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.139	-4.52	3.381	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242R	242	L	R	missense	low	0.0338393534733872	0.183025977054277	6	0.0747200422428867	-0.112609238245982	0.180287945192756	-0.159172609392546	-0.129301236052201	0.284813665996757	0.212395702075498	NA	NA	0.0522021974835875	-0.0579015992707727	0.461057420097708	0.439376843890078	0.429371165073305	0.503741736343326	0.463478640127604	NA	NA	0.496469975719214	0.458636200067813	NA	NA	p.Leu242Arg	1	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.139	-4.378	3.239	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242S	242	L	S	missense	low	-0.195999013615836	0.134692733787144	6	0.0549880783065056	-0.303773666675655	-0.0882243605560167	-0.13751125387718	-0.0922451205908389	-0.175966790651669	-0.0893765268007255	NA	NA	-0.447742990521123	-0.233151399253479	0.406425487385322	0.44399068596824	0.437383133370104	0.365869310648338	0.363530509303966	NA	NA	0.393628713615876	0.419222261154769	NA	NA	p.Leu242Ser	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.139	-3.952	2.813	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242T	242	L	T	missense	low	-0.158454550572632	0.256586765455232	6	0.104751108352751	-0.363762950284677	0.0468538491394118	0.152567776797336	0.173918843148205	-0.275979410528171	-0.23282009032073	NA	NA	-0.402995854480834	-0.3654185680516	0.396154303029253	0.505777162662612	0.494930914962351	0.335944034297035	0.316021445577672	NA	NA	0.402833426565028	0.389475179493478	NA	NA	p.Leu242Thr	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.139	-3.769	2.63	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242V	242	L	V	missense	possibly_wt-like	0.78360887221071	0.137024041918931	6	0.0559398308658523	0.673968818412377	0.893248926009042	0.543712697502791	0.694532864410559	0.854507564129851	0.897508517413405	NA	NA	0.855233207599506	0.856158382208148	0.662933584830131	0.589090549607864	0.60749379375552	0.674202697753354	0.690390657682507	NA	NA	0.661657529414923	0.664209640245339	NA	NA	p.Leu242Val	1	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.139	-2.175	1.036	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242W	242	L	W	missense	low	0.0995334767269114	0.0936391469183883	6	0.0382280216499265	0.0246079310928379	0.174459022360985	0.0549203714255278	0.168473671344696	0.120594402120038	0.140904700175367	NA	NA	-0.0687053554052896	0.181013070701129	0.478288531996713	0.484978385438895	0.493753604731174	0.454604868818139	0.439800543447746	NA	NA	0.471598678554531	0.512368462293686	NA	NA	p.Leu242Trp	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.139	-5.466	4.327	0.017797686	NA	NA	NA	NA	NA	NA	NA
L242X	242	L	X	nonsense	low	0.158475726548345	0.137766483712278	6	0.056242931458755	0.0482416065042305	0.26870984659246	0.264092753016274	0.287149492479497	0.140499481550229	0.265316702687749	NA	NA	-0.043309249061002	0.0371051786173231	0.48050482261837	0.529531845405342	0.519412714022325	0.460560767218548	0.481006280468162	NA	NA	0.476822786500006	0.480003364768578	NA	NA	p.Leu242Ter	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L242Y	242	L	Y	missense	possibly_low	0.344124289653593	0.506728214123966	6	0.206870927145916	-0.0613352770008107	0.749583856307997	-0.243353315327623	-0.0286719945253391	0.917089768043362	0.993721321559344	NA	NA	0.299862098703555	0.126097859468259	0.523716412145511	0.42144645708039	0.451128391452977	0.692928232081902	0.722256711001918	NA	NA	0.547414874129976	0.500017950161046	NA	NA	p.Leu242Tyr	0	35.2	24.5	15.5	0.937	12.1	167.7	-110	129.3	0	-7.1	0	1	14.73	0	0	0	0	8	20.6145010569367	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.139	-4.229	3.09	0.017797686	NA	NA	NA	NA	NA	NA	NA
T243A	243	T	A	missense	wt-like	1.03183673247731	0.0697187587741392	6	0.0284625640828048	0.976051131967351	1.08762233298727	0.958622006647399	0.939096297744959	1.03655444793906	1.10686117569098	NA	NA	1.05286295323152	1.09702351360995	0.710345767537774	0.677465722057009	0.660371286445615	0.728673856629217	0.75972906882698	NA	NA	0.70231097094733	0.718380564128217	NA	NA	p.Thr243Ala	1	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.738	-2.518	0.78	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243C	243	T	C	missense	wt-like	1.27751123522503	0.172890661352545	6	0.0705823169343432	1.13917243608833	1.41585003436174	1.10282074155569	1.0784669661689	1.19770541504569	1.38546707941752	NA	NA	1.42217288074741	1.47843432841498	0.777586270398759	0.708179875207106	0.690504865289856	0.776892643727293	0.85200442304892	NA	NA	0.778279897070225	0.804160419836945	NA	NA	p.Thr243Cys	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.738	-4.092	2.354	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243D	243	T	D	missense	wt-like	1.29334014137209	0.46879230534405	5	0.209650292415627	0.882433118889169	1.70424716385501	0.572849920352807	NA	1.11557654613526	1.42410577282773	NA	NA	1.5855961456158	1.76857232192884	0.811896891931581	0.595296742231905	NA	0.752318453974044	0.8648017079356	NA	NA	0.811896891931581	0.869412883199739	NA	NA	p.Thr243Asp	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.738	-3.023	1.285	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243E	243	T	E	missense	possibly_wt-like	0.802999434506726	0.320596143452076	6	0.130882827493618	0.546473806424467	1.05952506258898	0.925070414904105	1.32319929928494	0.616306360310862	0.935396568505732	NA	NA	0.469264888255421	0.548759075779293	0.636624299069584	0.670319274289014	0.743418876100619	0.602929323850155	0.702939326926627	NA	NA	0.582261887561329	0.595075082107786	NA	NA	p.Thr243Glu	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.738	-2.851	1.113	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243F	243	T	F	missense	wt-like	1.08642257386275	0.155302678002614	6	0.063402052799027	0.962156833830748	1.21068831389475	0.897417498215749	0.981852934504075	1.28415916296499	1.23086508895302	NA	NA	0.982144480654553	1.1420962778841	0.708140658841372	0.664429237051494	0.669615774539597	0.802760902165935	0.800799645107345	NA	NA	0.687763822283171	0.728517495399573	NA	NA	p.Thr243Phe	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.738	-4.548	2.81	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243G	243	T	G	missense	possibly_low	0.624875887838087	0.285451645642907	6	0.116535146343813	0.396471198071108	0.853280577605065	0.836605195226096	0.98612741098375	0.501818658941014	0.78100685817143	NA	NA	0.255102014542381	0.388595189163851	0.610074588634892	0.651476291322655	0.670539966663196	0.56867288594713	0.651804856986235	NA	NA	0.538207497686654	0.559053987397494	NA	NA	p.Thr243Gly	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.738	-3.349	1.611	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243H	243	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr243His	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.738	-4.019	2.281	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243I	243	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr243Ile	1	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.738	-3.078	1.34	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243K	243	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr243Lys	1	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.738	-2.858	1.12	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243L	243	T	L	missense	wt-like	0.87777871783234	0.158440385329562	6	0.0646830164512293	0.751002335176518	1.00455510048816	1.03938857723664	0.987215032788392	0.587197015276756	0.846221341232525	NA	NA	0.92181690474694	0.884833435712784	0.672089634809413	0.694668902237916	0.670775123298186	0.594219371089926	0.673404146320641	NA	NA	0.675354133791649	0.670658702140254	NA	NA	p.Thr243Leu	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.738	-2.897	1.159	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243M	243	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr243Met	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.738	-3.731	1.993	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243N	243	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr243Asn	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.738	-3.201	1.463	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243P	243	T	P	missense	low	0.113567562306302	0.23842527763895	6	0.0973367119994732	-0.0772088875862133	0.304344012198817	-0.0256335138006875	-0.301393518494445	0.321874508019374	0.279288784794601	NA	NA	0.256473901651765	0.150795211667204	0.495603154662601	0.467820506978679	0.392162788159414	0.514830896298422	0.485633888169158	NA	NA	0.538489701826583	0.505572421156044	NA	NA	p.Thr243Pro	1	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.738	-4.257	2.519	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243Q	243	T	Q	missense	wt-like	0.955470084297199	0.139242141003006	6	0.0568453660250053	0.844055214200192	1.06688495439421	0.925429460830107	0.974956073823411	0.991975822047624	1.13886643173579	NA	NA	0.711548989766508	0.990043727579762	0.682358201419059	0.670395750629573	0.668124592087444	0.71533526295164	0.770329333570102	NA	NA	0.63210095669292	0.694320652208544	NA	NA	p.Thr243Gln	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.738	-3.019	1.281	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243R	243	T	R	missense	wt-like	0.917734777613497	0.0926500514099453	6	0.0378242250994992	0.843600658675343	0.991868896551652	0.90557137172217	0.878593999235211	0.916593702662301	1.02915144524966	NA	NA	0.771873771533053	1.00462437527859	0.679472901977679	0.666166002077914	0.647289977422574	0.692779801877444	0.733991305172111	NA	NA	0.644510070415446	0.697599861416036	NA	NA	p.Thr243Arg	1	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.738	-2.759	1.021	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243S	243	T	S	missense	wt-like	1.0880937754644	0.176513357830968	6	0.0720612765785289	0.946856268690507	1.2293312822383	0.813137434824309	0.918881767701076	1.20184960704058	1.2366146231678	NA	NA	1.17680202585178	1.18127719420087	0.732567604232614	0.646477687225825	0.65600066713407	0.778132648147264	0.802703913104484	NA	NA	0.727805867103955	0.737329341361273	NA	NA	p.Thr243Ser	1	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.738	-2.394	0.656	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243V	243	T	V	missense	possibly_low	0.696914216316674	0.267418339666194	6	0.109173080007408	0.482938911420844	0.910889521212504	0.986528139683962	0.990970860283075	0.469347958595663	0.814906598042805	NA	NA	0.3923200813174	0.52741165997714	0.626653299433222	0.683409694065204	0.671587177406961	0.558957165247533	0.663032582109149	NA	NA	0.566433950324079	0.590274016757295	NA	NA	p.Thr243Val	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.738	-2.513	0.775	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243W	243	T	W	missense	possibly_low	0.674902295128758	0.279083284632587	6	0.113935273848293	0.451593261817395	0.898211328440122	0.677304665969445	0.138831742882665	0.904419080972798	0.766043222463605	NA	NA	0.685520520140669	0.877294538343368	0.636797805652169	0.617545474553755	0.487344670925325	0.689136972412715	0.646848842892783	NA	NA	0.626746768411555	0.668963192984642	NA	NA	p.Thr243Trp	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.738	-5.735	3.997	0.152744586	NA	NA	NA	NA	NA	NA	NA
T243X	243	T	X	nonsense	low	0.0184964504987044	0.47311657334434	6	0.193149032257948	-0.360068696375638	0.397061597373047	0.478156362310384	0.752178369931062	-0.326125898134379	-0.18190926657875	NA	NA	-0.3220568119288	-0.28926405260729	0.413042720428323	0.575127130855686	0.619957430511099	0.320939452860052	0.332883307554341	NA	NA	0.419482998336501	0.406602442520145	NA	NA	p.Thr243Ter	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T243Y	243	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr243Tyr	0	34.9	28.3	15.4	0.884	43	-72.4	-135.8	167.8	15.3374233128834	-5.1	0	1	16.35	0	0	0	0	7	23.1381157245138	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.738	-4.592	2.854	0.152744586	NA	NA	NA	NA	NA	NA	NA
E244A	244	E	A	missense	possibly_wt-like	0.824595233006407	0.192904022813829	6	0.0787527375373479	0.670242703749269	0.978947762263544	0.503337825490243	0.784538687599795	0.973477145681332	0.791117557291866	NA	NA	0.829807599763047	1.06529258221216	0.655790456275821	0.580490751536142	0.626954112057673	0.709800181448144	0.655153559688835	NA	NA	0.656427352862806	0.711244230780677	NA	NA	p.Glu244Ala	1	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.483	-2.703	0.22	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244C	244	E	C	missense	wt-like	1.06908179430015	0.197214169192805	6	0.0805123474282138	0.911280493030079	1.22688309557023	0.805395478157298	0.846261872187275	1.17238468107007	1.13786897545325	NA	NA	1.29859487532202	1.15398488361101	0.742025267329204	0.644828659979482	0.640299391020007	0.769316300236101	0.769998972186653	NA	NA	0.752859274267789	0.73119126039062	NA	NA	p.Glu244Cys	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.483	-5.411	2.928	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244D	244	E	D	missense	possibly_low	0.635855626748776	0.176984413449787	2	0.125146878914668	0.390572251298432	0.881139002199121	0.510708747834108	0.761002505663445	NA	NA	NA	NA	NA	NA	0.601963030720344	0.582060748928081	0.621865312512606	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu244Asp	1	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.483	-3.123	0.64	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244E	244	E	E	synonymous	low	0.28595923212369	0.406566085041577	4	0.203283042520788	-0.11246820988478	0.684386674132159	0.061325836518902	0.768155733158257	-0.142609695115105	0.456965053932705	NA	NA	NA	NA	0.515411849093615	0.486342741624132	0.623411924487301	0.375850254087688	0.544480956563098	NA	NA	NA	NA	NA	NA	p.Glu244=	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244F	244	E	F	missense	possibly_low	0.644841730770218	0.217673832187401	6	0.0888649698692243	0.470669590339301	0.819013871201135	0.470024852637725	0.996156870585046	0.637950839987746	0.809190039989451	NA	NA	0.485115390270786	0.470612391150553	0.597464046579233	0.573395129298346	0.67270845387129	0.609405676900507	0.661139235944377	NA	NA	0.585522416257959	0.577499777288505	NA	NA	p.Glu244Phe	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.483	-3.579	1.096	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244G	244	E	G	missense	wt-like	0.986548966630602	0.0440561134987981	6	0.0179858330203662	0.951297381678733	1.02180055158247	0.976139229947666	1.04484561537102	1.01319505883697	1.01093842113163	NA	NA	0.937368509530603	0.936806964965715	0.682791579594407	0.681196869071239	0.683235533538961	0.721684376950144	0.72795908105387	NA	NA	0.678553177810989	0.682347625649853	NA	NA	p.Glu244Gly	1	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.483	-3.034	0.551	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244H	244	E	H	missense	possibly_wt-like	0.764225787553322	0.446331953123609	4	0.223165976561805	0.326828510917475	1.20162306418917	1.10235357847441	1.07901294234328	NA	NA	NA	NA	0.145307789022074	0.730228840373517	0.663255406007692	0.708080370045473	0.690622911764656	NA	NA	NA	NA	0.515622268355353	0.635887900250728	NA	NA	p.Glu244His	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.483	-3.302	0.819	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244I	244	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu244Ile	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.483	-3.625	1.142	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244K	244	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu244Lys	1	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.483	-2.294	-0.189	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244L	244	E	L	missense	wt-like	0.998346294569832	0.207557503880079	6	0.084734996131989	0.832268753920993	1.16442383521867	0.739535416133088	0.789052050347777	1.09931651698328	0.941246710136068	NA	NA	1.23465690656677	1.18627016725201	0.721664592433002	0.630800547785758	0.627929954204065	0.747453209303379	0.704876916489401	NA	NA	0.739706909646868	0.738452268376603	NA	NA	p.Glu244Leu	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.483	-2.614	0.131	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244M	244	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu244Met	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.483	-3.983	1.5	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244N	244	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu244Asn	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.483	-4.044	1.561	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244P	244	E	P	missense	wt-like	1.10400573583629	0.188548793335721	6	0.0769747225483322	0.953138051921598	1.25487341975099	0.78738054438179	0.998457178862784	1.22749987165269	1.28981058526035	NA	NA	1.23191558718637	1.08897064767377	0.727856234511186	0.640991501246281	0.673205807594545	0.785807592148824	0.820322621752113	NA	NA	0.73914300633972	0.716569462682652	NA	NA	p.Glu244Pro	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.483	-2.443	-0.04	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244Q	244	E	Q	missense	possibly_wt-like	1.12396211332787	0.69752634642908	6	0.284763938483176	0.565835049805067	1.68208917685068	0.58259459312403	0.0748985436053686	1.07658267051683	1.36896526952202	NA	NA	1.87899302369004	1.76173857950895	0.793594930536884	0.597372345544814	0.473521560776158	0.740650901365875	0.846538959707894	NA	NA	0.872250118569797	0.867875964434001	NA	NA	p.Glu244Gln	1	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.483	-2.96	0.477	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244R	244	E	R	missense	possibly_wt-like	0.864226472574279	0.252187893232672	6	0.102955276287922	0.662437839031582	1.06601510611698	0.925264056452383	1.11712465110271	0.900364231330351	0.825089383555412	NA	NA	0.393217284238052	1.02429922876677	0.67914211013279	0.67036051970059	0.698863111756362	0.687923700564991	0.666405160103993	NA	NA	0.566618509517639	0.702024765031232	NA	NA	p.Glu244Arg	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.483	-2.103	-0.38	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244S	244	E	S	missense	wt-like	1.01487366036894	0.13364249075273	6	0.0545593183831345	0.907939361316942	1.12180795942094	1.00031872506906	1.10333184079269	0.942385406325445	0.846202708752726	NA	NA	1.22806468665447	0.968938594619238	0.692727510229567	0.686347071787809	0.695880943832073	0.700497066565077	0.673397975171177	NA	NA	0.73835085655923	0.689574076627061	NA	NA	p.Glu244Ser	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.483	-2.687	0.204	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244T	244	E	T	missense	wt-like	0.988245973705506	0.170801629669879	6	0.0697294733211698	0.851578717335067	1.12491323007595	0.946317630515964	0.943206041448147	1.20385447499508	1.15661649407032	NA	NA	0.732185841545169	0.947295359658354	0.679775693093969	0.674844905077181	0.661259861404106	0.778732534718184	0.776208222952821	NA	NA	0.636346061823799	0.684706481110757	NA	NA	p.Glu244Thr	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.483	-3.102	0.619	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244V	244	E	V	missense	possibly_low	0.65623351851175	0.311840797098603	6	0.127308472312393	0.406713497852645	0.905753539170855	1.11864972792254	0.924429557794412	0.462870926147126	0.637121975516512	NA	NA	0.277837909861262	0.516491013828646	0.595983786979421	0.711551429831296	0.657200164647279	0.557019139964342	0.604149626653439	NA	NA	0.54288438672518	0.587817947305403	NA	NA	p.Glu244Val	1	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.483	-3.43	0.947	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244W	244	E	W	missense	possibly_wt-like	0.854227860653626	0.188222059589096	6	0.0768413340548359	0.703621613382137	1.00483410792512	0.925206570817477	1.10678590068246	0.927799230417737	0.899664268718346	NA	NA	0.594784046815846	0.671127146469893	0.680726463096985	0.67034827533107	0.696627752232994	0.696132663897834	0.691104650862899	NA	NA	0.608081815413863	0.622595841980735	NA	NA	p.Glu244Trp	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.483	-5.731	3.248	0.208748488	NA	NA	NA	NA	NA	NA	NA
E244X	244	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu244Ter	1	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E244Y	244	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu244Tyr	0	35	31	12.8	0.283	360	360	-60.1	141.4	28.0373831775701	-1.2	0	1	20.85	1	66	0	0	5	25.304552217286	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.483	-4.525	2.042	0.208748488	NA	NA	NA	NA	NA	NA	NA
K245A	245	K	A	missense	wt-like	0.942996676651809	0.0853995321234547	6	0.0348642129958141	0.87466407483068	1.01132927847294	0.899238981090351	0.959064451434457	1.0032779055984	0.917159552433219	NA	NA	0.817209825924897	1.06202934342954	0.680858183621623	0.664817210663096	0.664688636289602	0.718717015914616	0.69689915658015	NA	NA	0.65383592685793	0.710510323557674	NA	NA	p.Lys245Ala	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.202	-3.361	2.159	NA	NA	NA	NA	NA	NA	NA	NA
K245C	245	K	C	missense	possibly_wt-like	0.768228708072832	0.472724010047538	2	0.334266353134312	0.113078694686033	1.42337872145963	1.10249506120714	0.43396235493852	NA	NA	NA	NA	NA	NA	0.629632944250888	0.7081105056935	0.551155382808276	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys245Cys	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.202	-5.383	4.181	NA	NA	NA	NA	NA	NA	NA	NA
K245D	245	K	D	missense	possibly_wt-like	0.749280217333417	0.21096869491864	6	0.0861276090419269	0.580473205536694	0.91808722913014	0.915948534370675	0.900933901460192	0.813994292710095	0.902862716270336	NA	NA	0.479162607205476	0.482779251983726	0.657100323170186	0.66837632495663	0.652120127214361	0.66208051912601	0.692163989078179	NA	NA	0.584297898574516	0.580236122264017	NA	NA	p.Lys245Asp	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.202	-3.735	2.533	NA	NA	NA	NA	NA	NA	NA	NA
K245E	245	K	E	missense	possibly_wt-like	0.972904783489034	0.344571032211408	6	0.140670534843676	0.697195601509442	1.24861396546863	1.47636228181989	0.742165868411553	0.537410485875955	1.05893077623633	NA	NA	0.802790955064842	1.21976833352564	0.697362113435338	0.787743763773084	0.617792609839876	0.579322494548435	0.743854334916034	NA	NA	0.650869891954642	0.745986055458461	NA	NA	p.Lys245Glu	1	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.202	-2.682	1.48	NA	NA	NA	NA	NA	NA	NA	NA
K245F	245	K	F	missense	wt-like	1.20817638679648	0.0986429736202421	3	0.0569515473733119	1.09655340508096	1.31979936851199	1.14314092733304	1.15971122942277	1.32167700363361	NA	NA	NA	NA	NA	0.716768025178003	0.716768025178003	0.708070831214308	0.813986802972242	NA	NA	NA	NA	NA	NA	NA	p.Lys245Phe	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.202	-4.576	3.374	NA	NA	NA	NA	NA	NA	NA	NA
K245G	245	K	G	missense	wt-like	0.883405599807529	0.194418465606288	6	0.0793710062183744	0.72784128620281	1.03896991341225	1.14306099392656	1.10398713152334	0.845275339335288	0.671202623413057	NA	NA	0.767095455029151	0.76981205561777	0.658115250709878	0.716750999460753	0.696022625400521	0.671440277584221	0.61543726921486	NA	NA	0.643527146463419	0.644790223835536	NA	NA	p.Lys245Gly	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.202	-3.642	2.44	NA	NA	NA	NA	NA	NA	NA	NA
K245H	245	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys245His	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.202	-4.614	3.412	NA	NA	NA	NA	NA	NA	NA	NA
K245I	245	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys245Ile	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.202	-4.294	3.092	NA	NA	NA	NA	NA	NA	NA	NA
K245L	245	K	L	missense	wt-like	0.90839527369276	0.080201769530927	6	0.0327422353031777	0.844221671725196	0.972568875660324	0.963374614713132	0.953096246179214	0.76666514128511	0.862766022557475	NA	NA	0.975977656544799	0.928491960876831	0.678680915286866	0.678478021728612	0.663398240070288	0.647918926942801	0.67888380884512	NA	NA	0.686495275270753	0.680477568946488	NA	NA	p.Lys245Leu	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.202	-3.654	2.452	NA	NA	NA	NA	NA	NA	NA	NA
K245M	245	K	M	missense	wt-like	0.949792203905118	0.240854068930252	6	0.0983282618920408	0.757072351934296	1.14251205587594	1.34808365808367	0.762242180850362	1.12203835179854	0.930218704748546	NA	NA	0.75926572725944	0.776904600690148	0.673804873049499	0.760420574718589	0.622133344878445	0.75425192317464	0.701224398398851	NA	NA	0.641916531729879	0.646385347700147	NA	NA	p.Lys245Met	1	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.202	-4.745	3.543	NA	NA	NA	NA	NA	NA	NA	NA
K245N	245	K	N	missense	wt-like	1.04326423828078	0.126419618539389	6	0.0516105931497994	0.94210933448642	1.14441914207513	1.20499667337377	1.05077674076675	0.995485480138343	1.17409777900368	NA	NA	0.881986170165918	0.952242586236193	0.701102262492134	0.729943222993136	0.684517912656234	0.716385405307605	0.781998092219424	NA	NA	0.667160749570544	0.685819119676662	NA	NA	p.Lys245Asn	1	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.202	-3.731	2.529	NA	NA	NA	NA	NA	NA	NA	NA
K245P	245	K	P	missense	wt-like	1.17793449327134	0.311951120079673	6	0.127353511480814	0.928326197464241	1.42754278907845	0.705017301186103	0.877001990081604	1.24208163995185	1.42820126717932	NA	NA	1.41346333873403	1.40184142249515	0.781711431113459	0.62344823176434	0.646945766306322	0.790170675993461	0.866158151524744	NA	NA	0.776488300082218	0.786934562144699	NA	NA	p.Lys245Pro	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.202	-4.01	2.808	NA	NA	NA	NA	NA	NA	NA	NA
K245Q	245	K	Q	missense	wt-like	0.883112017994958	0.139334937001496	6	0.056883249832751	0.771622896999172	0.994601138990744	0.610806997121108	0.970553331310328	0.981456270830443	0.946342585714989	NA	NA	0.920585057952156	0.86892786504072	0.671136701996423	0.603381552890841	0.667172667337788	0.712187655403167	0.706564690215033	NA	NA	0.675100736655057	0.667081515798771	NA	NA	p.Lys245Gln	1	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.202	-2.43	1.228	NA	NA	NA	NA	NA	NA	NA	NA
K245R	245	K	R	missense	possibly_wt-like	0.831916743813073	0.510945597320321	8	0.180646548341305	0.477856015132641	1.1859774724935	0.995774044387001	0.839318781373039	1.01022448068973	1.27568033575187	0.0903082656489889	-0.00945223227246616	1.25974113081437	1.19373914411204	0.703087297897102	0.685379060393147	0.638798213068868	0.720795535401057	0.815642628395191	0.519190747858931	0.478196424719147	0.744866861862434	0.740132052306361	NA	NA	p.Lys245Arg	1	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.202	-1.525	0.323	NA	NA	NA	NA	NA	NA	NA	NA
K245S	245	K	S	missense	possibly_low	0.665628859178015	0.262668085566268	6	0.107233796891845	0.455454479344516	0.875803239011513	0.810762332331994	0.785949404371105	0.767159374401462	0.889105335516771	NA	NA	0.176930560857045	0.56386614758971	0.636615459471912	0.645971793316682	0.627259125627141	0.648066808906168	0.687607491296828	NA	NA	0.522127232988963	0.598472684875661	NA	NA	p.Lys245Ser	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.202	-3.516	2.314	NA	NA	NA	NA	NA	NA	NA	NA
K245T	245	K	T	missense	wt-like	0.900250255975831	0.153632651762162	6	0.0627202674413328	0.777320790690098	1.02317972126156	1.02732709336229	1.05534890346345	0.886238755601119	0.935307560085876	NA	NA	0.625323080464748	0.871956142877507	0.684601807173299	0.692099821010053	0.685506468043588	0.68369714630301	0.702909846993283	NA	NA	0.614363849603258	0.667762579957946	NA	NA	p.Lys245Thr	1	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.202	-3.705	2.503	NA	NA	NA	NA	NA	NA	NA	NA
K245V	245	K	V	missense	possibly_low	0.671779318967659	0.553679558946299	8	0.195755285367652	0.2881060098637	1.05545262807162	0.942192694836071	0.834141500392598	1.00787497949347	1.07428601598205	-0.287082342681152	-0.144422709433852	1.01634735752515	0.930897055626932	0.677492388580236	0.673966298851634	0.637678823986595	0.720092529393689	0.748940049783335	0.46401068214614	0.452264314426836	0.69479952761514	0.681018478308838	NA	NA	p.Lys245Val	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.202	-3.884	2.682	NA	NA	NA	NA	NA	NA	NA	NA
K245W	245	K	W	missense	possibly_wt-like	0.836355714637716	0.3609154425318	6	0.147343112415616	0.547568520933072	1.12514290834236	1.44877268729773	0.888110606367147	0.490034281017905	0.916499026520204	NA	NA	0.452960265970956	0.821757420652355	0.652910196530784	0.781867214079068	0.649347579890746	0.565146823272112	0.696680387839858	NA	NA	0.578907944020948	0.656472813170821	NA	NA	p.Lys245Trp	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.202	-5.576	4.374	NA	NA	NA	NA	NA	NA	NA	NA
K245X	245	K	X	nonsense	possibly_wt-like	0.873035359028359	0.277217084939527	8	0.0980110403107533	0.680937249931979	1.06513346812474	1.06898361460932	1.04832628618275	0.596082073059711	0.709466813671539	1.2785328851695	1.08981532374345	0.619355924603355	0.573719951187252	0.656049306370914	0.700972608792105	0.683988095534409	0.596877913680656	0.628110517207418	0.692926689187235	0.689400593978171	0.613136375362728	0.600688819861795	NA	NA	p.Lys245Ter	1	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K245Y	245	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys245Tyr	0	38.4	31.7	11.3	0.287	360	360	-49.8	360	70.8695652173913	-1.9	0	0	26.04	1	36	0	0	4	28.0811942767444	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.202	-4.416	3.214	NA	NA	NA	NA	NA	NA	NA	NA
WT	NA	Z	Z	wt	wt-like	1	0	8	0	1	1	1	1	1	1	1	1	1	1	0.688857988479536	0.686279183740177	0.673539383682732	0.717736217381325	0.724336233615788	0.652201078725353	0.672144221101384	0.691436793218895	0.69655983258428	NA	NA	p.NA	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1	0.0545690187533609	1	1	NA	22.06977749	0.832891367