zeyu.md@hotmail.com Li, Quentin (NIH/NCI) [E] 2015-03-31T18:22:08Z 2017-01-10T16:35:10Z Hewlett-Packard 16.00 8520 20730 0 60 False False Table S1. A list of the differentially expressed proteins associated with cell survival and death in human urothelial bladder cancer UMUC3 cells in response to HSP90 inhibitor treatment. Identified proteins were functionally classified based on their annotation in the NCBI protein database (www.ncbi.nlm.nih.gov) and UniProt. Accession no.zeyu.md@hotmail.com: 3/31/2015 5:37:56 PM ActiveData Merge Sheets Sheet1: All_pathway_protein_ppm Sheet2: Sample1-10_ppm GroupBy Accession /Ascending Rows in Sheet1 that match a row in Sheet2 Rows in Sheet1 that don't match a row in Sheet2 Rows in Sheet2 that match a row in Sheet1 # Rows: 683 // UniProt Protein description Gene symbol Pathway Protein function Untreated (ppm) AUY-922 (ppm) SNX-2112 (ppm) Regulation of Cell Cycle 5921731 O95067 G2/mitotic-specific cyclin-B2 CCNB2 Cell cycle Cyclin 38.983846999999997 9.1262159999999994 19.761255999999999 166214910 P24863 Cyclin-C CCNC Cell cycle Cyclin 43.860270999999997 25.669498999999998 13.895725000000001 1706232 P51946 Cyclin-H CCNH Cell cycle Cyclin 28.821494000000001 0 0 160380581 Q5T5M9 Cyclin-J CCNJ Cell cycle Cyclin 8.3417049999999993 0 0 218511966 O75909 Cyclin-K CCNK Cell cycle Cyclin 16.050591000000001 0 6.7801549999999997 74753368 Q9UK58 Cyclin-L1 CCNL1 Cell cycle Cyclin 13.810776000000001 5.899457 0 9296942 O60563 Cyclin-T1 CCNT1 Cell cycle Cyclin 25.645572000000001 5.0030770000000002 5.4166530000000002 334302921 P06493 Cyclin-dependent kinase 1 CDK1 Cell cycle CDKs 449.272425 146.756933 211.851315 116051 P24941 Cyclin-dependent kinase 2 CDK2 Cell cycle CDKs 312.394046 158.45316500000001 263.92550599999998 1168867 P11802 Cyclin-dependent kinase 4 CDK4 Cell cycle CDKs 174.102116 35.962713999999998 64.892574999999994 4033704 Q00535 Cyclin-dependent kinase 5 CDK5 Cell cycle CDKs 170.03365400000001 24.878316000000002 80.804590000000005 266423 Q00534 Cyclin-dependent kinase 6 CDK6 Cell cycle CDKs 161.818838 33.425466999999998 48.251412000000002 1705722 P50613 Cyclin-dependent kinase 7 CDK7 Cell cycle CDKs 62.779767 20.995573 0 68067660 P50750 Cyclin-dependent kinase 9 CDK9 Cell cycle CDKs 116.783867 39.056280999999998 63.427258999999999 34978359 P21127 Cyclin-dependent kinase 11B CDK11B Cell cycle CDKs 54.646036000000002 31.981935 29.679169999999999 308153421 Q9NYV4 Cyclin-dependent kinase 12 CDK12 Cell cycle CDKs 45.817793000000002 4.8754819999999999 13.196275 66774048 Q14004 Cyclin-dependent kinase 13 CDK13 Cell cycle CDKs 32.837187 4.8045419999999996 15.605119 59803097 Q00537 Cyclin-dependent kinase 17 CDK17 Cell cycle CDKs 106.799341 13.889996999999999 30.076405999999999 17375734 O14976 Cyclin-G-associated kinase GAK Cell cycle CDKs 2.9996109999999998 0 0 461747 P33552 Cyclin-dependent kinases regulatory subunit 2 CKS2 Cell cycle CDKs 39.279926000000003 0 0 34395509 Q9UM13 Anaphase-promoting complex subunit 10 APC10 Cell cycle Mitosis factor 63.770108999999998 39.267395999999998 33.547179999999997 37537863 Q9UJX6 Anaphase-promoting complex subunit 2 ANC2 Cell cycle Mitosis factor 3.7750780000000002 0 0 205371737 Q9UJX5 Anaphase-promoting complex subunit 4 APC4 Cell cycle Mitosis factor 11.521464 0 0 37537861 Q9UJX4 Anaphase-promoting complex subunit 5 APC5 Cell cycle Mitosis factor 8.2201699999999995 0 0 294862527 Q9UJX3 Anaphase-promoting complex subunit 7 APC7 Cell cycle Mitosis factor 51.804910999999997 12.127660000000001 19.695276 6685264 O75419 Cell division control protein 45 homolog;CDC45;ortholog CDC45 Cell cycle Mitosis factor 10.965068 0 0 37537763 Q13042 Cell division cycle protein 16 homolog CDC16 Cell cycle Mitosis factor 30.030137 23.433768000000001 31.713629000000001 254763423 Q9UJX2 Cell division cycle protein 23 homolog CDC23 Cell cycle Mitosis factor 31.187076999999999 12.168288 13.174170999999999 12644198 P30260 Cell division cycle protein 27 homolog CDC27 Cell cycle Mitosis factor 3.7659150000000001 4.4080510000000004 4.7724390000000003 52783153 Q9Y6D9 Mitotic spindle assembly checkpoint protein MAD1 MD1L1 Cell cycle Mitosis factor 38.896974999999998 5.0588220000000002 21.908023 1168870 P42773 Cyclin-dependent kinase 4 inhibitor C CDN2C Cell cycle CDK inhibitor 0 43.240881999999999 0 2498443 Q13547 Histone deacetylase 1;HDAC1;ortholog HDAC1 Cell cycle HDAC 186.70189099999999 128.10784100000001 122.38039499999999 68068066 Q92769 Histone deacetylase 2;HDAC2;ortholog HDAC2 Cell cycle HDAC 222.55941899999999 163.74825799999999 153.10924299999999 19863257 Q13616 Cullin-1;CUL1;ortholog CUL1 Cell cycle Positive regulator 43.987442999999999 14.042142 40.541134 51338609 P62877 E3 ubiquitin-protein ligase RBX1;RBX1;ortholog RBX1 Cell cycle Positive regulator 143.66269399999999 33.631796999999999 145.64777900000001 52783797 P63208 S-phase kinase-associated protein 1;SKP1;ortholog SKP1 Cell cycle Positive regulator 323.637676 245.120092 289.50846899999999 1709658 P53350 Serine/threonine-protein kinase PLK1;PLK1;ortholog PLK1 Cell cycle Positive regulator 15.438378999999999 12.047211000000001 13.043085 41019490 P49736 DNA replication licensing factor MCM2;MCM2;ortholog MCM2 Cell cycle Positive regulator 264.31393000000003 132.59261599999999 169.65388400000001 19857543 P25205 DNA replication licensing factor MCM3;MCM3;ortholog MCM3 Cell cycle Positive regulator 253.47219899999999 143.850855 199.544668 68571766 P33991 DNA replication licensing factor MCM4;MCM4;ortholog MCM4 Cell cycle Positive regulator 168.99926600000001 92.594611999999998 136.703014 19858646 P33992 DNA replication licensing factor MCM5;MCM5;ortholog MCM5 Cell cycle Positive regulator 219.83915300000001 98.970956000000001 176.801323 2497824 Q14566 DNA replication licensing factor MCM6;MCM6;ortholog MCM6 Cell cycle Positive regulator 264.577337 185.81465499999999 258.65342500000003 20981696 P33993 DNA replication licensing factor MCM7;MCM7;ortholog MCM7 Cell cycle Positive regulator 397.06050800000003 166.70893599999999 377.38777900000002 76803807 Q13415 Origin recognition complex subunit 1;ORC1;ortholog ORC1 Cell cycle Positive regulator 3.604082 4.218623 0 8488999 Q13416 Origin recognition complex subunit 2;ORC2;ortholog ORC2 Cell cycle Positive regulator 21.512056999999999 12.590066 6.8154070000000004 8928268 Q9UBD5 Origin recognition complex subunit 3;ORC3;ortholog ORC3 Cell cycle Positive regulator 8.7288730000000001 5.1086270000000003 0 67477352 O43929 Origin recognition complex subunit 4;ORC4;ortholog ORC4 Cell cycle Positive regulator 42.703406000000001 33.323248999999997 0 6174924 O43913 Origin recognition complex subunit 5;ORC5;ortholog ORC5 Cell cycle Positive regulator 7.1335959999999998 0 9.0402070000000005 25091097 O60216 Double-strand-break repair protein rad21 homolog;RAD21;ortholog RAD21 Cell cycle Positive regulator 73.766581000000002 40.294196999999997 31.160777 51338669 P84022 Mothers against decapentaplegic homolog 3;SMAD3;ortholog SMAD3 Cell cycle Positive regulator 21.904335 0 0 13959561 Q13485 Mothers against decapentaplegic homolog 4;SMAD4;ortholog SMAD4 Cell cycle Positive regulator 11.243167 0 0 209572720 Q8WVM7 Cohesin subunit SA-1;STAG1;ortholog STAG1 Cell cycle Positive regulator 34.533861999999999 14.436541999999999 28.133872 135674 P01137 Transforming growth factor beta-1;TGFB1;ortholog TGFB1 Cell cycle Positive regulator 31.826812 9.3134209999999999 30.249922999999999 160112977 P33981 Dual specificity protein kinase TTK;TTK;ortholog TTK Cell cycle Positive regulator 10.86271 8.4766259999999996 9.1773399999999992 90103515 P28749 Retinoblastoma-like protein 1;RBL1;ortholog RBL1 Cell cycle Positive regulator 2.905538 0 0 132164 P06400 Retinoblastoma-associated protein RB Cell cycle Positive regulator 36.782603999999999 23.484272000000001 16.950388 1345590 P31946 14-3-3 protein beta/alpha;YWHAB;ortholog YWHAB Cell cycle Negative regulator 1173.1285359999999 1122.1536209999999 1278.8585499999999 51702210 P62258 14-3-3 protein epsilon;YWHAE;ortholog YWHAE Cell cycle Negative regulator 2226.9407719999999 2962.763492 3130.5705029999999 1345593 Q04917 14-3-3 protein eta;YWHAH;ortholog YWHAH Cell cycle Negative regulator 681.17140800000004 708.72860300000002 783.30086200000005 48428721 P61981 14-3-3 protein gamma;YWHAG;ortholog YWHAG Cell cycle Negative regulator 866.86185899999998 941.14567499999998 1257.7599720000001 112690 P27348 14-3-3 protein theta;YWHAQ;ortholog YWHAQ Cell cycle Negative regulator 899.26982699999996 1022.955723 1091.466623 52000887 P63104 14-3-3 protein zeta/delta;YWHAZ;ortholog YWHAZ Cell cycle Negative regulator 1443.8980320000001 1779.053431 1829.811692 143811368 O60566 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta;BUB1B BUB1B Cell cycle Negative regulator 2.9553470000000002 10.377812 14.980914 Regulation of Apoptosis 728945 Q07812 Apoptosis regulator BAX BAX Apoptosis Pro-apoptosis 321.60406 371.72722099999999 389.15266000000003 17371773 Q92934 Bcl2 antagonist of cell death BAD Apoptosis Pro-apoptosis 36.941836000000002 43.240881999999999 46.815358000000003 2493274 Q16611 Bcl-2 homologous antagonist/killer BAK Apoptosis Pro-apoptosis 0 17.214379999999998 29.413405000000001 2493285 P55957 BH3-interacting domain death agonist BID Apoptosis Pro-apoptosis 159.134061 223.522098 181.49954 23396740 Q9BXK5 Bcl-2-like protein 13 B2L13 Apoptosis Pro-apoptosis 6.398174 0 0 18203507 Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD ASC Apoptosis Pro-apoptosis 31.826812 37.253683000000002 40.333230999999998 2810997 O00273 DNA fragmentation factor subunit alpha;DFFA;ortholog DFFA Apoptosis Pro-apoptosis 28.124901999999999 109.735169 83.164441999999994 269849759 P04637 Cellular tumor antigen p53;TP53;ortholog TP53 Apoptosis Pro-apoptosis 102.647543 27.726977999999999 60.038015999999999 150417955 Q96HS1 Serine/threonine-protein phosphatase PGAM5 PGAM5 Apoptosis Necroptosis 364.48023699999999 450.97161299999999 367.395263 125987821 O00429 Dynamin-1-like protein DNM1L Apoptosis Necroptosis 59.026629 54.286107000000001 112.2042 12231007 P31944 Caspase-14 CASPE Apoptosis Caspase 0 30.018464000000002 32.499918000000001 77416852 P42574 Caspase-3 CASP3 Apoptosis Caspase 22.405156999999999 65.563792000000007 85.180289999999999 115612 P04632 Calpain small subunit 1 CPNS1 Apoptosis Calpain-calcium 324.20596 298.16847000000001 366.83675699999998 115574 P07384 Calpain-1 catalytic subunit CAN1 Apoptosis Calpain-calcium 60.845376000000002 71.220275999999998 77.107647999999998 317373596 P17655 Calpain-2 catalytic subunit CAN2 Apoptosis Calpain-calcium 172.88779099999999 145.28936400000001 258.42077399999999 13431764 O95831 Apoptosis-inducing factor 1, mitochondrial AIFM1 Apoptosis AIP-pathway 136.28284500000001 172.114001 141.133411 74752283 Q9BRQ8 Apoptosis-inducing factor 2 AIFM2 Apoptosis AIP-pathway 16.638681999999999 19.475785999999999 0 83304396 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1 Apoptosis Pro-survival 8.8660409999999992 0 0 109940027 Q13075 NAIP; Baculoviral IAP repeat-containing protein 1 BIRC1 Apoptosis Pro-survival 4.4235410000000002 2.588905 0 57012667 Q6FI81 Anamorsin CPIN1 Apoptosis Pro-survival 109.404667 81.492430999999996 100.833078 126302556 P20810 Calpastatin ICAL Apoptosis Pro-survival 87.214659999999995 70.126874000000001 61.098008999999998 60393639 Q13546 Receptor-interacting serine/threonine-protein kinase 1;RIPK1;ortholog RIPK1 Apoptosis Pro-survival 9.2492230000000006 0 0 23503103 Q12933 TNF receptor-associated factor 2;TRAF2;ortholog TRAF2 Apoptosis Pro-survival 12.387681000000001 0 0 317373368 O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha;CHUK;ortholog CHUK Apoptosis Pro-survival 4.165254 0 0 21542418 P19838 Nuclear factor NF-kappa-B p105 subunit;NFKB1;ortholog NFKB1 Apoptosis Pro-survival 12.187469 11.256924 0 317373311 O00459 Phosphatidylinositol 3-kinase regulatory subunit beta;PIK3R2;ortholog PIK3R2 Apoptosis Pro-survival 4.2625190000000002 0 0 125205 P17612 cAMP-dependent protein kinase catalytic subunit alpha;PRKACA;ortholog PRKACA Apoptosis Pro-survival 62.089472000000001 44.203906000000003 11.203675 125210 P22694 cAMP-dependent protein kinase catalytic subunit beta;PRKACB;ortholog PRKACB Apoptosis Pro-survival 41.392980999999999 26.522344 11.203675 33860173 P22612 cAMP-dependent protein kinase catalytic subunit gamma;PRKACG;ortholog PRKACG Apoptosis Pro-survival 8.8407809999999998 0 0 125198 P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit;PRKAR2A PRKAR2A Apoptosis Pro-survival 130.57658699999999 107.888141 48.669431000000003 62906901 Q04206 Transcription factor p65;RELA;ortholog RELA Apoptosis Pro-survival 65.920764000000005 45.054290000000002 28.548022 Regulation of DNA Damage Repair 37999897 P13051 Uracil-DNA glycosylase UNG DNA damage and repair Base excision repair 69.398719999999997 34.813744999999997 37.691597999999999 206729922 P29372 DNA-3-methyladenine glycosylase MPG DNA damage and repair Base excision repair 62.478808999999998 0 0 56404653 Q969S2 Endonuclease 8-like 2 NEIL2 DNA damage and repair Base excision repair 18.693459000000001 0 0 251757259 P49916 DNA ligase 3 LIG3 DNA damage and repair Base excision repair 28.798684999999999 21.528047000000001 15.589653 317373290 P18887 DNA repair protein XRCC1 XRCC1 DNA damage and repair Base excision repair 24.511171000000001 5.7381270000000004 6.2124649999999999 50401132 Q96T60 Bifunctional polynucleotide phosphatase/kinase PNKP DNA damage and repair Base excision repair 53.604660000000003 48.801609999999997 22.643896999999999 17380230 Q9UGN5 Poly [ADP-ribose] polymerase 2 PARP2 DNA damage and repair Base excision repair 10.645332 6.2302470000000003 0 74736661 Q6NS38 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 ALKBH2 DNA damage and repair Base excision repair 11.889326000000001 0 0 67462008 O95551 Tyrosyl-DNA phosphodiesterase 2 TDP2 DNA damage and repair Base excision repair 8.572139 0 0 544186 P06746 DNA polymerase beta POLB DNA damage and repair Base excision repair 9.2630269999999992 0 0 123369 P09429 High mobility group protein B1;HMGB1;ortholog HMGB1 DNA damage and repair Base excision repair 663.92210599999999 1182.587843 1207.1829889999999 296453081 Q01831 DNA repair protein complementing XP-C cells XPC DNA damage and repair Nucleotide excision repair 6.6023709999999998 0 0 12643730 Q16531 DNA damage-binding protein 1 DDB1 DNA damage and repair Nucleotide excision repair 264.03690899999998 105.143618 131.083001 12230033 Q92466 DNA damage-binding protein 2 DDB2 DNA damage and repair Nucleotide excision repair 14.534492999999999 0 0 119541 P19447 TFIIH basal transcription factor complex helicase XPB subunit ERCC3 DNA damage and repair Nucleotide excision repair 11.904529999999999 9.2896009999999993 0 119540 P18074 TFIIH basal transcription factor complex helicase XPD subunit ERCC2 DNA damage and repair Nucleotide excision repair 8.1660900000000005 4.779255 0 416727 P32780 General transcription factor IIH subunit 1 GTF2H1 DNA damage and repair Nucleotide excision repair 11.325234 0 0 17380326 Q13888 General transcription factor IIH subunit 2 GTF2H2 DNA damage and repair Nucleotide excision repair 31.423940999999999 9.1955290000000005 0 50403772 Q13889 General transcription factor IIH subunit 3 GTF2H3 DNA damage and repair Nucleotide excision repair 10.075046 11.792968 0 17380328 Q92759 General transcription factor IIH subunit 4 GTF2H4 DNA damage and repair Nucleotide excision repair 13.433395000000001 0 0 1705722 P50613 Cyclin-dependent kinase 7 CDK7 DNA damage and repair Nucleotide excision repair 62.779767 20.995573 0 1706232 P51946 Cyclin-H CCNH DNA damage and repair Nucleotide excision repair 28.821494000000001 0 0 1708932 P51948 CDK-activating kinase assembly factor MAT1 MNAT1 DNA damage and repair Nucleotide excision repair 40.169763000000003 11.754803000000001 0 25091548 Q9HCS7 Pre-mRNA-splicing factor SYF1 XAB2 DNA damage and repair Nucleotide excision repair 68.958093000000005 33.985816 41.394632000000001 296439468 Q13620 Cullin-4B;CUL4B;ortholog CUL4B DNA damage and repair Nucleotide excision repair 64.577404000000001 35.805154999999999 34.457743999999998 108936013 Q13619 Cullin-4A;CUL4A;ortholog CUL4A DNA damage and repair Nucleotide excision repair 65.414792000000006 19.142209000000001 31.086877999999999 1171032 P43246 DNA mismatch repair protein Msh2 MSH2 DNA damage and repair Mismatch excision repair 56.480665000000002 46.666818999999997 50.524496999999997 730028 P40692 DNA mismatch repair protein Mlh1 MLH1 DNA damage and repair Mismatch excision repair 53.360429000000003 4.8045419999999996 5.2017059999999997 548663 Q06609 DNA repair protein RAD51 homolog 1 RAD51 DNA damage and repair Homologous recombination 9.1537290000000002 0 0 60392986 Q92878 DNA repair protein RAD50 RAD50 DNA damage and repair Homologous recombination 155.86088599999999 71.980249000000001 125.35446 17380137 P49959 Double-strand break repair protein MRE11A MRE11A DNA damage and repair Homologous recombination 70.126874000000001 25.651371000000001 33.326186999999997 74762960 O60934 Nibrin NBN DNA damage and repair Homologous recombination 57.617505000000001 43.355578999999999 57.370544000000002 116242745 Q99708 DNA endonuclease RBBP8 RBBP8 DNA damage and repair Homologous recombination 3.4594360000000002 0 0 290457644 Q17RS7 Flap endonuclease GEN homolog 1 GEN1 DNA damage and repair Homologous recombination 6.8350530000000003 0 0 1705486 P54132 Bloom syndrome protein BLM DNA damage and repair Homologous recombination 4.3798370000000002 2.5633270000000001 5.5504449999999999 2501242 Q13472 DNA topoisomerase 3-alpha;TOP3A;ortholog TOP3A DNA damage and repair Homologous recombination 21.700099000000002 7.2572109999999999 0 38258929 P78527 DNA-dependent protein kinase catalytic subunit PRKDC DNA damage and repair Non-homologous end-joining 675.04761199999996 365.15919300000002 384.86578900000001 44888352 Q13426 DNA repair protein XRCC4 XRCC4 DNA damage and repair Non-homologous end-joining 9.2354590000000005 0 0 125731 P13010 X-ray repair cross-complementing protein 5 XRCC5 DNA damage and repair Non-homologous end-joining 741.86473100000001 411.85167899999999 456.64160299999998 125729 P12956 X-ray repair cross-complementing protein 6 XRCC6 DNA damage and repair Non-homologous end-joining 684.47281499999997 506.962065 606.35564699999998 48428109 Q8WXE1 ATR-interacting protein ATRIP DNA damage and repair Fanconi anemia 3.9230269999999998 0 0 166987394 Q9Y4R8 Telomere length regulation protein TEL2 homolog;TELO2;ortholog TELO2 DNA damage and repair Fanconi anemia 44.489091999999999 0 0 74760390 Q8TAF3 WD repeat-containing protein 48;WDR48;ortholog WDR48 DNA damage and repair Fanconi anemia 22.918125 10.730381 17.426100999999999 73622065 Q9NPD8 Ubiquitin-conjugating enzyme E2 T;UBE2T;ortholog UBE2T DNA damage and repair Fanconi anemia 63.007395000000002 36.875473 39.923757000000002 322510109 Q9H9A7 RecQ-mediated genome instability protein 1;RMI1;ortholog RMI1 DNA damage and repair Fanconi anemia 4.9649830000000001 0 0 74731517 Q96E14 RecQ-mediated genome instability protein 2;RMI2;ortholog RMI2 DNA damage and repair Fanconi anemia 42.219240999999997 0 0 121992 P16104 Histone H2AX H2AFX DNA damage and repair Chromatin structure and modification 4867.4876720000002 8712.2817649999997 7595.0347330000004 229462842 Q13111 Chromatin assembly factor 1 subunit A CHAF1A DNA damage and repair Chromatin structure and modification 9.7378060000000009 11.398224000000001 0 60390864 Q14527 Helicase-like transcription factor HLTF DNA damage and repair Ubiquitination and modification 30.754352999999998 17.999178000000001 3.8974129999999998 51701935 Q15819 Ubiquitin-conjugating enzyme E2 variant 2 UBE2V2 DNA damage and repair Ubiquitination and modification 342.4126 676.347037 678.01552400000003 46577660 P61088 Ubiquitin-conjugating enzyme E2 N UBE2N DNA damage and repair Ubiquitination and modification 673.70242299999995 740.784584 802.02099499999997 254763430 P36639 7,8-dihydro-8-oxoguanine triphosphatase NUDT1 DNA damage and repair Modulation of nucleotide pool 94.511092000000005 73.750945999999999 199.61878400000001 347595814 P33316 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial DUT DNA damage and repair Modulation of nucleotide pool 246.27890400000001 172.963528 436.94333799999998 74727333 Q7LG56 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B DNA damage and repair Modulation of nucleotide pool 44.203906000000003 0 33.611026000000003 322510082 Q14191 Werner syndrome ATP-dependent helicase WRN DNA damage and repair Other related 2.166979 0 0 18206225 O94761 ATP-dependent DNA helicase Q4 RECQL4 DNA damage and repair Other related 5.1376059999999999 0 0 71153365 Q8TAP9 M-phase-specific PLK1-interacting protein MPLKIP DNA damage and repair Other related 52.0075 81.167242000000002 65.907653999999994 68565390 Q14676 Mediator of DNA damage checkpoint protein 1 MDC1 DNA damage and repair Other related 105.46726099999999 50.423546000000002 79.063945000000004 74735450 O60671 Cell cycle checkpoint protein RAD1 RAD1 DNA damage and repair Other related 11.003951000000001 0 0 62287484 O75943 Cell cycle checkpoint protein RAD17 RAD17 DNA damage and repair Other related 4.5567019999999996 5.3336769999999998 0 317373343 O14757 Serine/threonine-protein kinase Chk1 CHEK1 DNA damage and repair Other related 19.557442000000002 0 0 269849759 P04637 Cellular tumor antigen p53 TP53 DNA damage and repair Other related 102.647543 27.726977999999999 60.038015999999999 8928568 Q12888 Tumor suppressor p53-binding protein 1 TP53BP1 DNA damage and repair Other related 91.268063999999995 29.470459000000002 35.894939999999998 68565701 Q5UIP0 Telomere-associated protein RIF1 RIF1 DNA damage and repair Other related 64.020560000000003 4.4080510000000004 17.498944000000002 296453012 Q92547 DNA topoisomerase 2-binding protein 1 TOPBP1 DNA damage and repair Other related 8.1553590000000007 0 2.5837650000000001 55976619 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 DNA damage and repair Other related 344.79046599999998 194.583969 202.86654999999999 218512113 P46063 ATP-dependent DNA helicase Q1 RECQL DNA damage and repair Other related 215.162001 240.656496 284.78741400000001 74761196 Q9BQ15 SOSS complex subunit B1 NABP2 DNA damage and repair Other related 0 17.214379999999998 37.274787000000003 129694 P12004 Proliferating cell nuclear antigen PCNA DNA damage and repair Other related 677.69160499999998 821.07973600000003 994.42276900000002 38258929 P78527 DNA-dependent protein kinase catalytic subunit;PRKDC;ortholog PRKDC DNA damage and repair Other related 675.04761199999996 365.15919300000002 384.86578900000001 223590203 Q09472 Histone acetyltransferase p300;EP300;ortholog EP300 DNA damage and repair Other related 6.4273280000000002 4.5139610000000001 3.25807 116241283 Q92793 CREB-binding protein;CREBBP;ortholog CREBBP DNA damage and repair Other related 11.436539 4.4622039999999998 4.8310690000000003 ROS Generation 134665 P04179 Superoxide dismutase [Mn] SODM Free radical 1128.9376219999999 1076.3053729999999 832.55419800000004 311033481 P07203 Glutathione peroxidase 1 GPX1 Free radical 152.86276799999999 35.785558000000002 38.743744 269849565 Q8TED1 Probable glutathione peroxidase 8 GPX8 Free radical 207.86410799999999 191.17021500000001 112.894451 12643338 Q9Y2Q3 Glutathione S-transferase kappa 1 GSTK1 Free radical 178.49771899999999 160.718323 156.60358600000001 6016173 P78417 Glutathione S-transferase omega-1 GSTO1 Free radical 115.883932 165.786618 228.44340500000001 121746 P09211 Glutathione S-transferase P GSTP1 Free radical 118.213874 276.74164500000001 355.796718 21264427 P30711 Glutathione S-transferase theta-1 GSTT1 Free radical 12.929641999999999 45.402926000000001 32.77075 14916998 P00390 Glutathione reductase GSHR Free radical 77.280621999999994 69.583028999999996 45.201034999999997 172046253 Q16881 Thioredoxin reductase 1 TRXR1 Free radical 325.13369 313.41311100000001 515.041068 182705230 Q9NNW7 Thioredoxin reductase 2 TRXR2 Free radical 11.843947 27.726977999999999 7.5047519999999999 1170328 P30519 Heme oxygenase 2 HMOX2 Free radical 78.559853000000004 34.483235000000001 24.889177 119554 P28482 Mitogen-activated protein kinase 1 MK01 Free radical 232.733564 141.25354799999999 142.006585 232066 P27361 Mitogen-activated protein kinase 3 MK03 Free radical 147.377455 134.172235 51.879815999999998 2507195 P45983 Mitogen-activated protein kinase 8 MK08 Free radical 7.2672460000000001 0 0 Regulation of Autophagy 254763436 Q13131 PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit PRKAA1 Regulation of autophagy 22.204753 38.986412000000001 49.244061000000002 20140441 O75143 ATG13; autophagy related 13 ATG13 Regulation of autophagy 0 7.0255979999999996 0 74762700 Q99570 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 PIK3R4 Regulation of autophagy 0 0 2.8957950000000001 74730233 Q8NEB9 PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 PIK3C3 Regulation of autophagy 0 8.1899300000000004 6.9968750000000002 62286592 O95352 ATG7; autophagy related 7 ATG7 Regulation of autophagy 48.555129999999998 31.000575000000001 33.563215 17366828 Q9H1Y0 ATG5; autophagy related 5 ATG5 Regulation of autophagy 22.568103000000001 0 14.299963999999999 62510482 Q676U5 ATG16L1; autophagy related 16-like 1 (S. cerevisiae) ATG16L1 Regulation of autophagy 25.561071999999999 11.967822 12.957134 44887916 O95166 GABARAP; GABA(A) receptor-associated protein GABARAP Regulation of autophagy 26.522344 62.089472000000001 33.611026000000003 44887973 Q9H0R8 GABARAPL1; GABA(A) receptor-associated protein like 1 GABARAPL1 Regulation of autophagy 26.522344 31.044736 0 44888808 P60520 GABARAPL2; GABA(A) receptor-associated protein-like 2 GABARAPL2 Regulation of autophagy 26.522344 93.134207000000004 302.499234 296434400 Q9Y4P1 ATG4B; autophagy related 4B, cysteine peptidase ATG4B Regulation of autophagy 31.583859 9.2423260000000003 0 61212142 Q9NT62 ATG3; autophagy related 3 ATG3 Regulation of autophagy 34.702872999999997 39.530116999999997 50.095415000000003 .