{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Table S2"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table S2","index":0,"n_rows":243,"n_cols":5,"rows_kept":243,"flags":["formulas_cached_only"]}
["Table S2"]
["mRNA targets and canonical pathways potentially affected by miRs altered in exosomes from denervated fibers"]
[]
["Ingenuity Canonical Pathways"," -log(p-value)","Ratio","z-score","Molecules"]
["Myc Mediated Apoptosis Signaling",{"v":3.19,"d":"3.19E+00"},{"v":0.0714,"d":"7.14E-02"},"NaN","YWHAQ,CASP9,IGF1,IGF1R,BCL2"]
["IGF-1 Signaling",{"v":3.18,"d":"3.18E+00"},{"v":0.0566,"d":"5.66E-02"},"NaN","YWHAQ,CTGF,CASP9,IGF1,IGF1R,SRF"]
["Calcium Signaling",{"v":2.7,"d":"2.70E+00"},{"v":0.0393,"d":"3.93E-02"},"NaN","HDAC4,MEF2A,TPM3,TPM1,NFATC4,TPM4,TPM2"]
["Purine Ribonucleosides Degradation to Ribose-1-phosphate",{"v":2.58,"d":"2.58E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","PNP,PGM2"]
["Huntington's Disease Signaling",{"v":2.55,"d":"2.55E+00"},{"v":0.0332,"d":"3.32E-02"},"NaN","HDAC4,CASP9,IGF1,BDNF,IGF1R,POLR2K,DNAJB1,EGFR"]
["UDP-N-acetyl-D-galactosamine Biosynthesis II",{"v":2.3,"d":"2.30E+00"},{"v":0.182,"d":"1.82E-01"},"NaN","GNPNAT1,GNPDA2"]
["STAT3 Pathway",{"v":2.23,"d":"2.23E+00"},{"v":0.0548,"d":"5.48E-02"},"NaN","PIM1,IGF1R,EGFR,BCL2"]
["PTEN Signaling",{"v":2.18,"d":"2.18E+00"},{"v":0.042,"d":"4.20E-02"},"NaN","CASP9,INPP5F,IGF1R,EGFR,BCL2"]
["Estrogen-Dependent Breast Cancer Signaling",{"v":2.14,"d":"2.14E+00"},{"v":0.0519,"d":"5.19E-02"},"NaN","IGF1,IGF1R,ESR1,EGFR"]
["Cardiac Hypertrophy Signaling",{"v":2.04,"d":"2.04E+00"},{"v":0.0298,"d":"2.98E-02"},"NaN","HAND2,IGF1,RHOA,IGF1R,SRF,MEF2A,NFATC4"]
["PEDF Signaling",{"v":2.01,"d":"2.01E+00"},{"v":0.0476,"d":"4.76E-02"},"NaN","BDNF,RHOA,SRF,BCL2"]
["Hepatic Fibrosis / Hepatic Stellate Cell Activation",{"v":2.01,"d":"2.01E+00"},{"v":0.0328,"d":"3.28E-02"},"NaN","MET,CTGF,IGF1,IGF1R,EGFR,BCL2"]
["Xanthine and Xanthosine Salvage",{"v":2,"d":"2.00E+00"},{"v":1,"d":"1.00E+00"},"NaN","PNP"]
["Chondroitin Sulfate Biosynthesis (Late Stages)",{"v":1.9,"d":"1.90E+00"},{"v":0.0612,"d":"6.12E-02"},"NaN","UST,CHSY1,CHST11"]
["Clathrin-mediated Endocytosis Signaling",{"v":1.86,"d":"1.86E+00"},{"v":0.0305,"d":"3.05E-02"},"NaN","MET,IGF1,PICALM,GAK,ITGB4,F2"]
["Epithelial Adherens Junction Signaling",{"v":1.82,"d":"1.82E+00"},{"v":0.0342,"d":"3.42E-02"},"NaN","MET,NOTCH2,NOTCH3,RHOA,EGFR"]
["Semaphorin Signaling in Neurons",{"v":1.81,"d":"1.81E+00"},{"v":0.0566,"d":"5.66E-02"},"NaN","MET,RHOA,NRP1"]
["Cholecystokinin/Gastrin-mediated Signaling",{"v":1.74,"d":"1.74E+00"},{"v":0.0396,"d":"3.96E-02"},"NaN","RHOA,SRF,MEF2A,EGFR"]
["Guanine and Guanosine Salvage I",{"v":1.71,"d":"1.71E+00"},{"v":0.5,"d":"5.00E-01"},"NaN","PNP"]
["Adenine and Adenosine Salvage I",{"v":1.71,"d":"1.71E+00"},{"v":0.5,"d":"5.00E-01"},"NaN","PNP"]
["Chondroitin Sulfate Biosynthesis",{"v":1.7,"d":"1.70E+00"},{"v":0.0517,"d":"5.17E-02"},"NaN","UST,CHSY1,CHST11"]
["Dermatan Sulfate Biosynthesis",{"v":1.67,"d":"1.67E+00"},{"v":0.05,"d":"5.00E-02"},"NaN","UST,CHSY1,CHST11"]
["Superpathway of Inositol Phosphate Compounds",{"v":1.61,"d":"1.61E+00"},{"v":0.0268,"d":"2.68E-02"},"NaN","INPP5F,IP6K2,HACD2,PXYLP1,PTPRF,EGFR"]
["ERK5 Signaling",{"v":1.61,"d":"1.61E+00"},{"v":0.0476,"d":"4.76E-02"},"NaN","YWHAQ,MEF2A,EGFR"]
["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis",{"v":1.55,"d":"1.55E+00"},{"v":0.0259,"d":"2.59E-02"},"NaN","CASP9,IGF1,RUNX2,NFATC4,LRP1,BCL2"]
["Tetrahydrobiopterin Biosynthesis I",{"v":1.53,"d":"1.53E+00"},{"v":0.333,"d":"3.33E-01"},"NaN","GCH1"]
["Tetrahydrobiopterin Biosynthesis II",{"v":1.53,"d":"1.53E+00"},{"v":0.333,"d":"3.33E-01"},"NaN","GCH1"]
["N-acetylglucosamine Degradation I",{"v":1.53,"d":"1.53E+00"},{"v":0.333,"d":"3.33E-01"},"NaN","GNPDA2"]
["Agrin Interactions at Neuromuscular Junction",{"v":1.51,"d":"1.51E+00"},{"v":0.0435,"d":"4.35E-02"},"NaN","UTRN,AGRN,EGFR"]
["Caveolar-mediated Endocytosis Signaling",{"v":1.48,"d":"1.48E+00"},{"v":0.0423,"d":"4.23E-02"},"NaN","ARCN1,ITGB4,EGFR"]
["PI3K/AKT Signaling",{"v":1.46,"d":"1.46E+00"},{"v":0.0323,"d":"3.23E-02"},"NaN","YWHAQ,INPP5F,MCL1,BCL2"]
["Estrogen Receptor Signaling",{"v":1.41,"d":"1.41E+00"},{"v":0.0312,"d":"3.12E-02"},"NaN","DDX5,RUNX2,POLR2K,ESR1"]
["Arsenate Detoxification I (Glutaredoxin)",{"v":1.41,"d":"1.41E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","PNP"]
["Pentose Phosphate Pathway (Oxidative Branch)",{"v":1.41,"d":"1.41E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","G6PD"]
["Branched-chain Î±-keto acid Dehydrogenase Complex",{"v":1.41,"d":"1.41E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","BCKDHB"]
["Heme Biosynthesis from Uroporphyrinogen-III I",{"v":1.41,"d":"1.41E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","CPOX"]
["Glycerol-3-phosphate Shuttle",{"v":1.41,"d":"1.41E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","GPD2"]
["Arginine Degradation I (Arginase Pathway)",{"v":1.41,"d":"1.41E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","OAT"]
["N-acetylglucosamine Degradation II",{"v":1.41,"d":"1.41E+00"},{"v":0.25,"d":"2.50E-01"},"NaN","GNPDA2"]
["Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells",{"v":1.4,"d":"1.40E+00"},{"v":0.0625,"d":"6.25E-02"},"NaN","CASP9,BCL2"]
["Regulation of the Epithelial-Mesenchymal Transition Pathway",{"v":1.4,"d":"1.40E+00"},{"v":0.0265,"d":"2.65E-02"},"NaN","MET,NOTCH2,NOTCH3,RHOA,EGFR"]
["Role of NFAT in Cardiac Hypertrophy",{"v":1.37,"d":"1.37E+00"},{"v":0.026,"d":"2.60E-02"},"NaN","HDAC4,IGF1,IGF1R,MEF2A,NFATC4"]
["Growth Hormone Signaling",{"v":1.33,"d":"1.33E+00"},{"v":0.037,"d":"3.70E-02"},"NaN","IGF1,IGF1R,SRF"]
["Macropinocytosis Signaling",{"v":1.33,"d":"1.33E+00"},{"v":0.037,"d":"3.70E-02"},"NaN","MET,RHOA,ITGB4"]
["IL-8 Signaling",{"v":1.33,"d":"1.33E+00"},{"v":0.0254,"d":"2.54E-02"},"NaN","RAB11FIP2,RHOA,LASP1,EGFR,BCL2"]
["Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate",{"v":1.31,"d":"1.31E+00"},{"v":0.2,"d":"2.00E-01"},"NaN","MTHFD2"]
["autophagy",{"v":1.31,"d":"1.31E+00"},{"v":0.0556,"d":"5.56E-02"},"NaN","RB1CC1,BCL2"]
["Hereditary Breast Cancer Signaling",{"v":1.28,"d":"1.28E+00"},{"v":0.0282,"d":"2.82E-02"},"NaN","HDAC4,ARID1A,ARID2,POLR2K"]
["Notch Signaling",{"v":1.27,"d":"1.27E+00"},{"v":0.0526,"d":"5.26E-02"},"NaN","NOTCH2,NOTCH3"]
["HER-2 Signaling in Breast Cancer",{"v":1.25,"d":"1.25E+00"},{"v":0.0341,"d":"3.41E-02"},"NaN","CASP9,ITGB4,EGFR"]
["Inhibition of Matrix Metalloproteases",{"v":1.25,"d":"1.25E+00"},{"v":0.0513,"d":"5.13E-02"},"NaN","TIMP3,LRP1"]
["3-phosphoinositide Degradation",{"v":1.24,"d":"1.24E+00"},{"v":0.0274,"d":"2.74E-02"},"NaN","INPP5F,HACD2,PXYLP1,PTPRF"]
["Arginine Biosynthesis IV",{"v":1.24,"d":"1.24E+00"},{"v":0.167,"d":"1.67E-01"},"NaN","OAT"]
["Proline Biosynthesis II (from Arginine)",{"v":1.24,"d":"1.24E+00"},{"v":0.167,"d":"1.67E-01"},"NaN","OAT"]
["Chondroitin and Dermatan Biosynthesis",{"v":1.24,"d":"1.24E+00"},{"v":0.167,"d":"1.67E-01"},"NaN","CHSY1"]
["Arginine Degradation VI (Arginase 2 Pathway)",{"v":1.24,"d":"1.24E+00"},{"v":0.167,"d":"1.67E-01"},"NaN","OAT"]
["Glycerol Degradation I",{"v":1.24,"d":"1.24E+00"},{"v":0.167,"d":"1.67E-01"},"NaN","GPD2"]
["UDP-N-acetyl-D-glucosamine Biosynthesis II",{"v":1.24,"d":"1.24E+00"},{"v":0.167,"d":"1.67E-01"},"NaN","GNPNAT1"]
["Apoptosis Signaling",{"v":1.23,"d":"1.23E+00"},{"v":0.0337,"d":"3.37E-02"},"NaN","CASP9,MCL1,BCL2"]
["PDGF Signaling",{"v":1.22,"d":"1.22E+00"},{"v":0.0333,"d":"3.33E-02"},"NaN","INPP5F,SRF,SPHK1"]
["Glucocorticoid Receptor Signaling",{"v":1.18,"d":"1.18E+00"},{"v":0.0209,"d":"2.09E-02"},"NaN","ARID1A,ARID2,POLR2K,NFATC4,ESR1,BCL2"]
["Integrin Signaling",{"v":1.17,"d":"1.17E+00"},{"v":0.0228,"d":"2.28E-02"},"NaN","ARF3,ARF4,RHOA,ITGB4,TSPAN4"]
["Adenine and Adenosine Salvage III",{"v":1.17,"d":"1.17E+00"},{"v":0.143,"d":"1.43E-01"},"NaN","PNP"]
["Glioblastoma Multiforme Signaling",{"v":1.13,"d":"1.13E+00"},{"v":0.0252,"d":"2.52E-02"},"NaN","IGF1,RHOA,IGF1R,EGFR"]
["Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency",{"v":1.12,"d":"1.12E+00"},{"v":0.0435,"d":"4.35E-02"},"NaN","MEF2A,ASH2L"]
["Dermatan Sulfate Biosynthesis (Late Stages)",{"v":1.12,"d":"1.12E+00"},{"v":0.0435,"d":"4.35E-02"},"NaN","UST,CHST11"]
["Histidine Degradation III",{"v":1.12,"d":"1.12E+00"},{"v":0.125,"d":"1.25E-01"},"NaN","MTHFD2"]
["Citrulline Biosynthesis",{"v":1.12,"d":"1.12E+00"},{"v":0.125,"d":"1.25E-01"},"NaN","OAT"]
["Inositol Pyrophosphates Biosynthesis",{"v":1.12,"d":"1.12E+00"},{"v":0.125,"d":"1.25E-01"},"NaN","IP6K2"]
["Heme Biosynthesis II",{"v":1.07,"d":"1.07E+00"},{"v":0.111,"d":"1.11E-01"},"NaN","CPOX"]
["GDP-glucose Biosynthesis",{"v":1.07,"d":"1.07E+00"},{"v":0.111,"d":"1.11E-01"},"NaN","PGM2"]
["Folate Transformations I",{"v":1.07,"d":"1.07E+00"},{"v":0.111,"d":"1.11E-01"},"NaN","MTHFD2"]
["Phospholipase C Signaling",{"v":1.06,"d":"1.06E+00"},{"v":0.0211,"d":"2.11E-02"},"NaN","HDAC4,RHOA,MEF2A,ARHGEF18,NFATC4"]
["Docosahexaenoic Acid (DHA) Signaling",{"v":1.03,"d":"1.03E+00"},{"v":0.0385,"d":"3.85E-02"},"NaN","CASP9,BCL2"]
["Glucose and Glucose-1-phosphate Degradation",{"v":1.02,"d":"1.02E+00"},{"v":0.1,"d":"1.00E-01"},"NaN","PGM2"]
["Pentose Phosphate Pathway",{"v":1.02,"d":"1.02E+00"},{"v":0.1,"d":"1.00E-01"},"NaN","G6PD"]
["Glioma Signaling",{"v":1.02,"d":"1.02E+00"},{"v":0.0273,"d":"2.73E-02"},"NaN","IGF1,IGF1R,EGFR"]
["Amyotrophic Lateral Sclerosis Signaling",{"v":1.01,"d":"1.01E+00"},{"v":0.027,"d":"2.70E-02"},"NaN","CASP9,IGF1,BCL2"]
["p53 Signaling",{"v":1.01,"d":"1.01E+00"},{"v":0.027,"d":"2.70E-02"},"NaN","THBS1,SERPINB5,BCL2"]
["Glycogen Degradation II",{"v":0.985,"d":"9.85E-01"},{"v":0.0909,"d":"9.09E-02"},"NaN","PGM2"]
["Neuropathic Pain Signaling In Dorsal Horn Neurons",{"v":0.984,"d":"9.84E-01"},{"v":0.0263,"d":"2.63E-02"},"NaN","BDNF,TAC1,KCNH2"]
["Nur77 Signaling in T Lymphocytes",{"v":0.962,"d":"9.62E-01"},{"v":0.0351,"d":"3.51E-02"},"NaN","CASP9,BCL2"]
["3-phosphoinositide Biosynthesis",{"v":0.958,"d":"9.58E-01"},{"v":0.0217,"d":"2.17E-02"},"NaN","HACD2,PXYLP1,PTPRF,EGFR"]
["Pancreatic Adenocarcinoma Signaling",{"v":0.95,"d":"9.50E-01"},{"v":0.0254,"d":"2.54E-02"},"NaN","CASP9,EGFR,BCL2"]
["Induction of Apoptosis by HIV1",{"v":0.925,"d":"9.25E-01"},{"v":0.0333,"d":"3.33E-02"},"NaN","CASP9,BCL2"]
["Sphingosine-1-phosphate Signaling",{"v":0.918,"d":"9.18E-01"},{"v":0.0246,"d":"2.46E-02"},"NaN","CASP9,RHOA,SPHK1"]
["RhoA Signaling",{"v":0.918,"d":"9.18E-01"},{"v":0.0246,"d":"2.46E-02"},"NaN","IGF1,RHOA,IGF1R"]
["Role of Tissue Factor in Cancer",{"v":0.918,"d":"9.18E-01"},{"v":0.0246,"d":"2.46E-02"},"NaN","CTGF,F2,EGFR"]
["Glycogen Degradation III",{"v":0.916,"d":"9.16E-01"},{"v":0.0769,"d":"7.69E-02"},"NaN","PGM2"]
["NAD Phosphorylation and Dephosphorylation",{"v":0.916,"d":"9.16E-01"},{"v":0.0769,"d":"7.69E-02"},"NaN","PXYLP1"]
["Guanosine Nucleotides Degradation III",{"v":0.916,"d":"9.16E-01"},{"v":0.0769,"d":"7.69E-02"},"NaN","PNP"]
["Activation of IRF by Cytosolic Pattern Recognition Receptors",{"v":0.901,"d":"9.01E-01"},{"v":0.0323,"d":"3.23E-02"},"NaN","PPIB,ADAR"]
["PCP pathway",{"v":0.89,"d":"8.90E-01"},{"v":0.0317,"d":"3.17E-02"},"NaN","RHOA,SDC4"]
["DNA Double-Strand Break Repair by Homologous Recombination",{"v":0.886,"d":"8.86E-01"},{"v":0.0714,"d":"7.14E-02"},"NaN","POLA1"]
["Ubiquinol-10 Biosynthesis (Eukaryotic)",{"v":0.886,"d":"8.86E-01"},{"v":0.0714,"d":"7.14E-02"},"NaN","BCKDHB"]
["Superpathway of Citrulline Metabolism",{"v":0.886,"d":"8.86E-01"},{"v":0.0714,"d":"7.14E-02"},"NaN","OAT"]
["Urate Biosynthesis/Inosine 5'-phosphate Degradation",{"v":0.886,"d":"8.86E-01"},{"v":0.0714,"d":"7.14E-02"},"NaN","PNP"]
["D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis",{"v":0.866,"d":"8.66E-01"},{"v":0.0233,"d":"2.33E-02"},"NaN","HACD2,PXYLP1,PTPRF"]
["D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis",{"v":0.866,"d":"8.66E-01"},{"v":0.0233,"d":"2.33E-02"},"NaN","HACD2,PXYLP1,PTPRF"]
["GÎ±12/13 Signaling",{"v":0.859,"d":"8.59E-01"},{"v":0.0231,"d":"2.31E-02"},"NaN","RHOA,MEF2A,F2"]
["p70S6K Signaling",{"v":0.852,"d":"8.52E-01"},{"v":0.0229,"d":"2.29E-02"},"NaN","YWHAQ,F2,EGFR"]
["Heparan Sulfate Biosynthesis (Late Stages)",{"v":0.847,"d":"8.47E-01"},{"v":0.0299,"d":"2.99E-02"},"NaN","UST,CHST11"]
["Breast Cancer Regulation by Stathmin1",{"v":0.846,"d":"8.46E-01"},{"v":0.0197,"d":"1.97E-02"},"NaN","RHOA,RB1CC1,ARHGEF18,UHMK1"]
["EGF Signaling",{"v":0.837,"d":"8.37E-01"},{"v":0.0294,"d":"2.94E-02"},"NaN","SRF,EGFR"]
["Granzyme B Signaling",{"v":0.832,"d":"8.32E-01"},{"v":0.0625,"d":"6.25E-02"},"NaN","CASP9"]
["Extrinsic Prothrombin Activation Pathway",{"v":0.832,"d":"8.32E-01"},{"v":0.0625,"d":"6.25E-02"},"NaN","F2"]
["Î³-glutamyl Cycle",{"v":0.832,"d":"8.32E-01"},{"v":0.0625,"d":"6.25E-02"},"NaN","ANPEP"]
["Methionine Degradation I (to Homocysteine)",{"v":0.832,"d":"8.32E-01"},{"v":0.0625,"d":"6.25E-02"},"NaN","EHMT1"]
["Parkinson's Signaling",{"v":0.832,"d":"8.32E-01"},{"v":0.0625,"d":"6.25E-02"},"NaN","CASP9"]
["Glioma Invasiveness Signaling",{"v":0.817,"d":"8.17E-01"},{"v":0.0286,"d":"2.86E-02"},"NaN","TIMP3,RHOA"]
["Adenosine Nucleotides Degradation II",{"v":0.808,"d":"8.08E-01"},{"v":0.0588,"d":"5.88E-02"},"NaN","PNP"]
["Ephrin B Signaling",{"v":0.788,"d":"7.88E-01"},{"v":0.0274,"d":"2.74E-02"},"NaN","RHOA,CAP1"]
["Valine Degradation I",{"v":0.785,"d":"7.85E-01"},{"v":0.0556,"d":"5.56E-02"},"NaN","BCKDHB"]
["D-myo-inositol (1,4,5)-trisphosphate Degradation",{"v":0.785,"d":"7.85E-01"},{"v":0.0556,"d":"5.56E-02"},"NaN","INPP5F"]
["Cysteine Biosynthesis III (mammalia)",{"v":0.785,"d":"7.85E-01"},{"v":0.0556,"d":"5.56E-02"},"NaN","EHMT1"]
["Heparan Sulfate Biosynthesis",{"v":0.77,"d":"7.70E-01"},{"v":0.0267,"d":"2.67E-02"},"NaN","UST,CHST11"]
["Ovarian Cancer Signaling",{"v":0.766,"d":"7.66E-01"},{"v":0.0208,"d":"2.08E-02"},"NaN","GJA1,EGFR,BCL2"]
["Non-Small Cell Lung Cancer Signaling",{"v":0.752,"d":"7.52E-01"},{"v":0.026,"d":"2.60E-02"},"NaN","CASP9,EGFR"]
["D-myo-inositol-5-phosphate Metabolism",{"v":0.748,"d":"7.48E-01"},{"v":0.0204,"d":"2.04E-02"},"NaN","HACD2,PXYLP1,PTPRF"]
["1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian)",{"v":0.744,"d":"7.44E-01"},{"v":0.05,"d":"5.00E-02"},"NaN","INPP5F"]
["Purine Nucleotides Degradation II (Aerobic)",{"v":0.744,"d":"7.44E-01"},{"v":0.05,"d":"5.00E-02"},"NaN","PNP"]
["D-myo-inositol (1,3,4)-trisphosphate Biosynthesis",{"v":0.744,"d":"7.44E-01"},{"v":0.05,"d":"5.00E-02"},"NaN","INPP5F"]
["Role of BRCA1 in DNA Damage Response",{"v":0.744,"d":"7.44E-01"},{"v":0.0256,"d":"2.56E-02"},"NaN","ARID1A,ARID2"]
["Endoplasmic Reticulum Stress Pathway",{"v":0.725,"d":"7.25E-01"},{"v":0.0476,"d":"4.76E-02"},"NaN","CASP9"]
["Small Cell Lung Cancer Signaling",{"v":0.695,"d":"6.95E-01"},{"v":0.0238,"d":"2.38E-02"},"NaN","CASP9,BCL2"]
["HIPPO signaling",{"v":0.679,"d":"6.79E-01"},{"v":0.0233,"d":"2.33E-02"},"NaN","YWHAQ,STK3"]
["Tumoricidal Function of Hepatic Natural Killer Cells",{"v":0.673,"d":"6.73E-01"},{"v":0.0417,"d":"4.17E-02"},"NaN","CASP9"]
["Estrogen-mediated S-phase Entry",{"v":0.673,"d":"6.73E-01"},{"v":0.0417,"d":"4.17E-02"},"NaN","ESR1"]
["Bladder Cancer Signaling",{"v":0.672,"d":"6.72E-01"},{"v":0.023,"d":"2.30E-02"},"NaN","THBS1,EGFR"]
["IL-4 Signaling",{"v":0.672,"d":"6.72E-01"},{"v":0.023,"d":"2.30E-02"},"NaN","INPP5F,NFATC4"]
["TGF-Î² Signaling",{"v":0.672,"d":"6.72E-01"},{"v":0.023,"d":"2.30E-02"},"NaN","RUNX2,BCL2"]
["IL-17A Signaling in Gastric Cells",{"v":0.657,"d":"6.57E-01"},{"v":0.04,"d":"4.00E-02"},"NaN","EGFR"]
["Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism",{"v":0.657,"d":"6.57E-01"},{"v":0.04,"d":"4.00E-02"},"NaN","INPP5F"]
["Glycolysis I",{"v":0.657,"d":"6.57E-01"},{"v":0.04,"d":"4.00E-02"},"NaN","PKM"]
["NAD Salvage Pathway II",{"v":0.642,"d":"6.42E-01"},{"v":0.0385,"d":"3.85E-02"},"NaN","PXYLP1"]
["Colorectal Cancer Metastasis Signaling",{"v":0.64,"d":"6.40E-01"},{"v":0.0162,"d":"1.62E-02"},"NaN","CASP9,RHOA,LRP1,EGFR"]
["Death Receptor Signaling",{"v":0.636,"d":"6.36E-01"},{"v":0.0217,"d":"2.17E-02"},"NaN","CASP9,BCL2"]
["Ceramide Signaling",{"v":0.63,"d":"6.30E-01"},{"v":0.0215,"d":"2.15E-02"},"NaN","SPHK1,BCL2"]
["IL-15 Production",{"v":0.628,"d":"6.28E-01"},{"v":0.037,"d":"3.70E-02"},"NaN","TWF1"]
["Prostate Cancer Signaling",{"v":0.623,"d":"6.23E-01"},{"v":0.0213,"d":"2.13E-02"},"NaN","CASP9,BCL2"]
["Mitochondrial Dysfunction",{"v":0.62,"d":"6.20E-01"},{"v":0.0175,"d":"1.75E-02"},"NaN","CASP9,GPD2,BCL2"]
["RhoGDI Signaling",{"v":0.611,"d":"6.11E-01"},{"v":0.0173,"d":"1.73E-02"},"NaN","RHOA,ARHGEF18,ESR1"]
["Intrinsic Prothrombin Activation Pathway",{"v":0.601,"d":"6.01E-01"},{"v":0.0345,"d":"3.45E-02"},"NaN","F2"]
["Glutathione-mediated Detoxification",{"v":0.601,"d":"6.01E-01"},{"v":0.0345,"d":"3.45E-02"},"NaN","ANPEP"]
["Superpathway of Methionine Degradation",{"v":0.576,"d":"5.76E-01"},{"v":0.0323,"d":"3.23E-02"},"NaN","EHMT1"]
["UVA-Induced MAPK Signaling",{"v":0.573,"d":"5.73E-01"},{"v":0.0196,"d":"1.96E-02"},"NaN","CASP9,EGFR"]
["Axonal Guidance Signaling",{"v":0.547,"d":"5.47E-01"},{"v":0.0134,"d":"1.34E-02"},"NaN","MET,IGF1,BDNF,RHOA,NFATC4,NRP1"]
["Oncostatin M Signaling",{"v":0.542,"d":"5.42E-01"},{"v":0.0294,"d":"2.94E-02"},"NaN","TIMP3"]
["TWEAK Signaling",{"v":0.542,"d":"5.42E-01"},{"v":0.0294,"d":"2.94E-02"},"NaN","CASP9"]
["Inhibition of Angiogenesis by TSP1",{"v":0.542,"d":"5.42E-01"},{"v":0.0294,"d":"2.94E-02"},"NaN","THBS1"]
["Coagulation System",{"v":0.532,"d":"5.32E-01"},{"v":0.0286,"d":"2.86E-02"},"NaN","F2"]
["Nucleotide Excision Repair Pathway",{"v":0.532,"d":"5.32E-01"},{"v":0.0286,"d":"2.86E-02"},"NaN","POLR2K"]
["Type I Diabetes Mellitus Signaling",{"v":0.527,"d":"5.27E-01"},{"v":0.0182,"d":"1.82E-02"},"NaN","CASP9,BCL2"]
["NRF2-mediated Oxidative Stress Response",{"v":0.525,"d":"5.25E-01"},{"v":0.0155,"d":"1.55E-02"},"NaN","PPIB,DNAJB1,HACD3"]
["Corticotropin Releasing Hormone Signaling",{"v":0.522,"d":"5.22E-01"},{"v":0.018,"d":"1.80E-02"},"NaN","BDNF,MEF2A"]
["Androgen Signaling",{"v":0.522,"d":"5.22E-01"},{"v":0.018,"d":"1.80E-02"},"NaN","POLR2K,DNAJB1"]
["Telomerase Signaling",{"v":0.522,"d":"5.22E-01"},{"v":0.018,"d":"1.80E-02"},"NaN","HDAC4,EGFR"]
["Interferon Signaling",{"v":0.521,"d":"5.21E-01"},{"v":0.0278,"d":"2.78E-02"},"NaN","BCL2"]
["ILK Signaling",{"v":0.513,"d":"5.13E-01"},{"v":0.0153,"d":"1.53E-02"},"NaN","RHOA,FERMT2,ITGB4"]
["Molecular Mechanisms of Cancer",{"v":0.506,"d":"5.06E-01"},{"v":0.0134,"d":"1.34E-02"},"NaN","CASP9,RHOA,ARHGEF18,LRP1,BCL2"]
["ERK/MAPK Signaling",{"v":0.502,"d":"5.02E-01"},{"v":0.0151,"d":"1.51E-02"},"NaN","YWHAQ,SRF,ESR1"]
["April Mediated Signaling",{"v":0.502,"d":"5.02E-01"},{"v":0.0263,"d":"2.63E-02"},"NaN","NFATC4"]
["Netrin Signaling",{"v":0.493,"d":"4.93E-01"},{"v":0.0256,"d":"2.56E-02"},"NaN","NFATC4"]
["Rac Signaling",{"v":0.492,"d":"4.92E-01"},{"v":0.0171,"d":"1.71E-02"},"NaN","RHOA,IQGAP3"]
["p38 MAPK Signaling",{"v":0.492,"d":"4.92E-01"},{"v":0.0171,"d":"1.71E-02"},"NaN","SRF,MEF2A"]
["Thrombin Signaling",{"v":0.487,"d":"4.87E-01"},{"v":0.0148,"d":"1.48E-02"},"NaN","RHOA,F2,EGFR"]
["Role of PKR in Interferon Induction and Antiviral Response",{"v":0.484,"d":"4.84E-01"},{"v":0.025,"d":"2.50E-02"},"NaN","CASP9"]
["B Cell Activating Factor Signaling",{"v":0.484,"d":"4.84E-01"},{"v":0.025,"d":"2.50E-02"},"NaN","NFATC4"]
["Thyroid Cancer Signaling",{"v":0.484,"d":"4.84E-01"},{"v":0.025,"d":"2.50E-02"},"NaN","BDNF"]
["Neuroprotective Role of THOP1 in Alzheimer's Disease",{"v":0.484,"d":"4.84E-01"},{"v":0.025,"d":"2.50E-02"},"NaN","TAC1"]
["phagosome maturation",{"v":0.477,"d":"4.77E-01"},{"v":0.0167,"d":"1.67E-02"},"NaN","ATP6V0A1,ATP6V1B2"]
["phagosome formation",{"v":0.468,"d":"4.68E-01"},{"v":0.0164,"d":"1.64E-02"},"NaN","MRC2,RHOA"]
["UVC-Induced MAPK Signaling",{"v":0.466,"d":"4.66E-01"},{"v":0.0238,"d":"2.38E-02"},"NaN","EGFR"]
["Protein Kinase A Signaling",{"v":0.465,"d":"4.65E-01"},{"v":0.0128,"d":"1.28E-02"},"NaN","YWHAQ,PTPRK,RHOA,NFATC4,PTPRF"]
["Serotonin Receptor Signaling",{"v":0.458,"d":"4.58E-01"},{"v":0.0233,"d":"2.33E-02"},"NaN","GCH1"]
["Role of IL-17F in Allergic Inflammatory Airway Diseases",{"v":0.45,"d":"4.50E-01"},{"v":0.0227,"d":"2.27E-02"},"NaN","IGF1"]
["IL-6 Signaling",{"v":0.446,"d":"4.46E-01"},{"v":0.0157,"d":"1.57E-02"},"NaN","SRF,MCL1"]
["Adipogenesis pathway",{"v":0.417,"d":"4.17E-01"},{"v":0.0149,"d":"1.49E-02"},"NaN","HDAC4,NFATC4"]
["TNFR1 Signaling",{"v":0.413,"d":"4.13E-01"},{"v":0.0204,"d":"2.04E-02"},"NaN","CASP9"]
["Cell Cycle: G2/M DNA Damage Checkpoint Regulation",{"v":0.413,"d":"4.13E-01"},{"v":0.0204,"d":"2.04E-02"},"NaN","YWHAQ"]
["Assembly of RNA Polymerase II Complex",{"v":0.407,"d":"4.07E-01"},{"v":0.02,"d":"2.00E-02"},"NaN","POLR2K"]
["Actin Cytoskeleton Signaling",{"v":0.406,"d":"4.06E-01"},{"v":0.0132,"d":"1.32E-02"},"NaN","RHOA,F2,IQGAP3"]
["CD27 Signaling in Lymphocytes",{"v":0.394,"d":"3.94E-01"},{"v":0.0192,"d":"1.92E-02"},"NaN","CASP9"]
["Aryl Hydrocarbon Receptor Signaling",{"v":0.394,"d":"3.94E-01"},{"v":0.0143,"d":"1.43E-02"},"NaN","POLA1,ESR1"]
["Insulin Receptor Signaling",{"v":0.39,"d":"3.90E-01"},{"v":0.0142,"d":"1.42E-02"},"NaN","INPP5F,PTPRF"]
["Human Embryonic Stem Cell Pluripotency",{"v":0.383,"d":"3.83E-01"},{"v":0.014,"d":"1.40E-02"},"NaN","BDNF,SPHK1"]
["Unfolded protein response",{"v":0.381,"d":"3.81E-01"},{"v":0.0185,"d":"1.85E-02"},"NaN","BCL2"]
["Synaptic Long Term Depression",{"v":0.372,"d":"3.72E-01"},{"v":0.0137,"d":"1.37E-02"},"NaN","IGF1,IGF1R"]
["Actin Nucleation by ARP-WASP Complex",{"v":0.369,"d":"3.69E-01"},{"v":0.0179,"d":"1.79E-02"},"NaN","RHOA"]
["Regulation of Cellular Mechanics by Calpain Protease",{"v":0.363,"d":"3.63E-01"},{"v":0.0175,"d":"1.75E-02"},"NaN","EGFR"]
["Wnt/Ca+ pathway",{"v":0.363,"d":"3.63E-01"},{"v":0.0175,"d":"1.75E-02"},"NaN","NFATC4"]
["ATM Signaling",{"v":0.352,"d":"3.52E-01"},{"v":0.0169,"d":"1.69E-02"},"NaN","TDP1"]
["Ephrin A Signaling",{"v":0.347,"d":"3.47E-01"},{"v":0.0167,"d":"1.67E-02"},"NaN","RHOA"]
["eNOS Signaling",{"v":0.342,"d":"3.42E-01"},{"v":0.0129,"d":"1.29E-02"},"NaN","CASP9,ESR1"]
["Retinoic acid Mediated Apoptosis Signaling",{"v":0.342,"d":"3.42E-01"},{"v":0.0164,"d":"1.64E-02"},"NaN","CASP9"]
["GÎ±q Signaling",{"v":0.327,"d":"3.27E-01"},{"v":0.0125,"d":"1.25E-02"},"NaN","RHOA,NFATC4"]
["Endometrial Cancer Signaling",{"v":0.327,"d":"3.27E-01"},{"v":0.0156,"d":"1.56E-02"},"NaN","CASP9"]
["Pyridoxal 5'-phosphate Salvage Pathway",{"v":0.327,"d":"3.27E-01"},{"v":0.0156,"d":"1.56E-02"},"NaN","PIM1"]
["Cell Cycle: G1/S Checkpoint Regulation",{"v":0.327,"d":"3.27E-01"},{"v":0.0156,"d":"1.56E-02"},"NaN","HDAC4"]
["UVB-Induced MAPK Signaling",{"v":0.317,"d":"3.17E-01"},{"v":0.0152,"d":"1.52E-02"},"NaN","EGFR"]
["Lymphotoxin Î² Receptor Signaling",{"v":0.313,"d":"3.13E-01"},{"v":0.0149,"d":"1.49E-02"},"NaN","CASP9"]
["GABA Receptor Signaling",{"v":0.313,"d":"3.13E-01"},{"v":0.0149,"d":"1.49E-02"},"NaN","KCNH2"]
["Remodeling of Epithelial Adherens Junctions",{"v":0.308,"d":"3.08E-01"},{"v":0.0147,"d":"1.47E-02"},"NaN","MET"]
["Wnt/Î²-catenin Signaling",{"v":0.301,"d":"3.01E-01"},{"v":0.0118,"d":"1.18E-02"},"NaN","GJA1,LRP1"]
["Chemokine Signaling",{"v":0.295,"d":"2.95E-01"},{"v":0.0141,"d":"1.41E-02"},"NaN","RHOA"]
["Role of MAPK Signaling in the Pathogenesis of Influenza",{"v":0.291,"d":"2.91E-01"},{"v":0.0139,"d":"1.39E-02"},"NaN","BCL2"]
["GM-CSF Signaling",{"v":0.287,"d":"2.87E-01"},{"v":0.0137,"d":"1.37E-02"},"NaN","PIM1"]
["PPARÎ±/RXRÎ± Activation",{"v":0.278,"d":"2.78E-01"},{"v":0.0112,"d":"1.12E-02"},"NaN","CAND1,GPD2"]
["Role of PI3K/AKT Signaling in the Pathogenesis of Influenza",{"v":0.275,"d":"2.75E-01"},{"v":0.0132,"d":"1.32E-02"},"NaN","CASP9"]
["GDNF Family Ligand-Receptor Interactions",{"v":0.275,"d":"2.75E-01"},{"v":0.0132,"d":"1.32E-02"},"NaN","PDLIM7"]
["Neurotrophin/TRK Signaling",{"v":0.275,"d":"2.75E-01"},{"v":0.0132,"d":"1.32E-02"},"NaN","BDNF"]
["BMP signaling pathway",{"v":0.275,"d":"2.75E-01"},{"v":0.0132,"d":"1.32E-02"},"NaN","RUNX2"]
["NF-ÎºB Signaling",{"v":0.273,"d":"2.73E-01"},{"v":0.0111,"d":"1.11E-02"},"NaN","IGF1R,EGFR"]
["Angiopoietin Signaling",{"v":0.271,"d":"2.71E-01"},{"v":0.013,"d":"1.30E-02"},"NaN","CASP9"]
["Dopamine Receptor Signaling",{"v":0.271,"d":"2.71E-01"},{"v":0.013,"d":"1.30E-02"},"NaN","GCH1"]
["Xenobiotic Metabolism Signaling",{"v":0.268,"d":"2.68E-01"},{"v":0.0105,"d":"1.05E-02"},"NaN","HDAC4,UST,CHST11"]
["VDR/RXR Activation",{"v":0.267,"d":"2.67E-01"},{"v":0.0128,"d":"1.28E-02"},"NaN","RUNX2"]
["Cyclins and Cell Cycle Regulation",{"v":0.267,"d":"2.67E-01"},{"v":0.0128,"d":"1.28E-02"},"NaN","HDAC4"]
["Role of NFAT in Regulation of the Immune Response",{"v":0.266,"d":"2.66E-01"},{"v":0.0109,"d":"1.09E-02"},"NaN","MEF2A,NFATC4"]
["Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes",{"v":0.264,"d":"2.64E-01"},{"v":0.0127,"d":"1.27E-02"},"NaN","NFATC4"]
["B Cell Receptor Signaling",{"v":0.261,"d":"2.61E-01"},{"v":0.0108,"d":"1.08E-02"},"NaN","INPP5F,NFATC4"]
["Renal Cell Carcinoma Signaling",{"v":0.257,"d":"2.57E-01"},{"v":0.0123,"d":"1.23E-02"},"NaN","MET"]
["AMPK Signaling",{"v":0.252,"d":"2.52E-01"},{"v":0.0106,"d":"1.06E-02"},"NaN","ARID1A,ARID2"]
["RAR Activation",{"v":0.25,"d":"2.50E-01"},{"v":0.0105,"d":"1.05E-02"},"NaN","ARID1A,ARID2"]
["LPS-stimulated MAPK Signaling",{"v":0.24,"d":"2.40E-01"},{"v":0.0116,"d":"1.16E-02"},"NaN","SRF"]
["Neuregulin Signaling",{"v":0.234,"d":"2.34E-01"},{"v":0.0114,"d":"1.14E-02"},"NaN","EGFR"]
["G Beta Gamma Signaling",{"v":0.234,"d":"2.34E-01"},{"v":0.0114,"d":"1.14E-02"},"NaN","EGFR"]
["VEGF Family Ligand-Receptor Interactions",{"v":0.234,"d":"2.34E-01"},{"v":0.0114,"d":"1.14E-02"},"NaN","NRP1"]
["Crosstalk between Dendritic Cells and Natural Killer Cells",{"v":0.231,"d":"2.31E-01"},{"v":0.0112,"d":"1.12E-02"},"NaN","FSCN1"]
["OX40 Signaling Pathway",{"v":0.231,"d":"2.31E-01"},{"v":0.0112,"d":"1.12E-02"},"NaN","BCL2"]
["FGF Signaling",{"v":0.228,"d":"2.28E-01"},{"v":0.0111,"d":"1.11E-02"},"NaN","MET"]
["Regulation of Actin-based Motility by Rho",{"v":0.225,"d":"2.25E-01"},{"v":0.011,"d":"1.10E-02"},"NaN","RHOA"]
["Acute Myeloid Leukemia Signaling",{"v":0.225,"d":"2.25E-01"},{"v":0.011,"d":"1.10E-02"},"NaN","PIM1"]
["Factors Promoting Cardiogenesis in Vertebrates",{"v":0.222,"d":"2.22E-01"},{"v":0.0109,"d":"1.09E-02"},"NaN","LRP1"]
["Salvage Pathways of Pyrimidine Ribonucleotides",{"v":0.219,"d":"2.19E-01"},{"v":0.0108,"d":"1.08E-02"},"NaN","PIM1"]
["Melanocyte Development and Pigmentation Signaling",{"v":0.213,"d":"2.13E-01"},{"v":0.0105,"d":"1.05E-02"},"NaN","BCL2"]
["ErbB Signaling",{"v":0.205,"d":"2.05E-01"},{"v":0.0102,"d":"1.02E-02"},"NaN","EGFR"]
["CDK5 Signaling",{"v":0.203,"d":"2.03E-01"},{"v":0.0101,"d":"1.01E-02"},"NaN","BDNF"]
["FAK Signaling",{"v":0.203,"d":"2.03E-01"},{"v":0.0101,"d":"1.01E-02"},"NaN","EGFR"]