{"text_format":"3","workbook":"xls","n_sheets":19,"sheets":["Muscle","Cuticle","Hemolymph","Malpiggi","Fat","Sugar","Mitochondrial","Metabolism","Detoxification","Cell death","Defense and immunity","other","Sensorial","Signaling","Hormone_related","Stress","CNS genes","Behaviour","Gene expression"],"not_rendered":{"external_links":1,"defined_names":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Muscle","index":0,"n_rows":37,"n_cols":2,"rows_kept":37,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["Troponin T","binds to tropomyosin and helps position it on actin"]
["tropomyosin 1","actin filament regulation in muscle and non-muscle cells "]
["microtubule-actin cross-linking factor 1-like"]
["Titin","contains binding sites for muscle-associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells"]
["Myophilin","muscle specific"]
["troponin C, isoform 1-like"]
["Myosin heavy chain"]
["muscle LIM protein"]
["wings apart","necessary for normal wing development and for jump muscle"]
["myosin heavy chain muscle isoform 3"]
["myosin heavy chain"]
["Cysteine-rich protein 1","regulates actin filament bundling by directly cross-linking actin filaments and stabilizing the interaction of α-actinin with actin filament bundles"]
["Actin"]
["Actin-binding LIM protein 1"]
["troponin C","muscle activity "]
["coronin-6","crosslinks actin and microtubules"]
["rolling pebbles","myotube formation"]
["Atlastin","required for normal growth of muscles and synapses at the neuromuscular junction"]
["Filamin-B","actin binding protein "]
["Gelsolin","actin binding protein"]
["Monocarboxylate transporter","transport lactate--muscles activity"]
["Actin-Binding LIM Protein"]
["coronin-2B","actin binding"]
["actin-interacting protein 1"]
["Actin-related protein 2/3 complex subunit 1A"]
["wings up","interacts with actin and regulate muscle contraction, it is a troponin "]
["Zeelin1","skeletal muscle myosin thick filament assembly "]
["anoctamin-5","form calcium-activated chloride chanel and are most abundant in skeletal muscles used for movement"]
["muscle fatty acid binding protein (FABP)"]
["muscle protein 20"]
["troponin C type IIb"]
["muscle LIM protein Mlp84B"]
["twitchin","related to tintin, muscle activity"]
["indirect flight muscle-like sequence"]
["selenoprotein N"]
["Colmedin (collagen repeat- plus olfactomedin-containing proteins)","involved in maintaining a structural microenvironment that allows efficient neuromuscular signaling at the synapses"]

{"sheet":"Cuticle","index":1,"n_rows":7,"n_cols":2,"rows_kept":7,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["cuticular protein 49Ae"]
["cuticular protein 78"]
["cystinosin","involved in melanine synthesis"]
["cuticular protein analogous to peritrophins 3-E"]
["chitinase-like protein Idgf4"]
["PREDICTED: laccase-1-like isoform 1","Phenoloxydase involved in cuticle tanning"]

{"sheet":"Hemolymph","index":2,"n_rows":3,"n_cols":1,"rows_kept":3,"flags":["formulas_cached_only"]}
["Gene"]
["hemolymph lipopolysaccharide-binding protein"]
["secreted ferritin G subunit"]

{"sheet":"Malpiggi","index":3,"n_rows":4,"n_cols":1,"rows_kept":4,"flags":["formulas_cached_only"]}
["Gene"]
["inverted formin-2"]
["Sodium-dependent phosphate transporter"]
["lymnokinin receptor"]

{"sheet":"Fat","index":4,"n_rows":79,"n_cols":2,"rows_kept":79,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["adipokinetic hormone I","It is a lipid mobilising hormone and is responsible for regulating fuel transport in the haemolymph, for redirecting energy to other processes as required by the insect"]
["adipokinetic hormone II"]
["phosphatidate phosphatase LPIN1","Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism"]
["pancreatic lipase-related protein 2-like, "]
["Apolipophorin-Iii","plays critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage"]
["adipokinetic hormone receptor","involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis."]
["Long-chain-fatty-acid--CoA ligase"," (activates the breakdown of complex fatty acids)"]
["Retinoid- and fatty-acid binding protein CG11064-PA"]
["fatty acid synthase S-acetyltransferase","fatty acids biosythesis"]
["Apolipophorins","function in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the insect adult life stage, play critical roles in lipid transport and lipoprotein metabolism "]
["phospholipase"]
["pancreatic lipase-related protein 2-like"]
["acidic lipase"]
["elongation of very long chain fatty acids protein"]
["PREDICTED: similar to elongation of very long chain fatty acids protein 4"]
["acyl-CoA:lysophosphatidylglycerol acyltransferase 1","reticulo endoplasmico specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor"]
["niemann-Pick C1 protein","neurovisceral lipid storage disorder resulting from autosomal recessively inherited loss-of-function mutations in either NPC1 (or NPC2). This disrupts intracellular lipid transport, leading to the accumulation of lipid products in the late endosomes and lysosomes. Associated with obesity"]
["TBC1 domain family member 9","asociated with sever obesity, esta proteina Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells"]
["Stearoyl-CoA desaturase","Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in Stearoyl-CoA. This is how the monounsaturated fatty acid oleic acid is produced from the saturated fatty acid stearic acid"]
["Atlastin","Endoplasmic reticulum morphology, lipid droplet size"]
["fatty acyl-CoA reductase 1"]
["lipid storage droplets surface-binding protein 2"]
["Putative lipid storage droplet-2 "]
["2-acylglycerol O-acyltransferase 1","glycerolipid metabolism "]
["apolipoprotein of lipid transfer particle-III"]
["pyruvate carboxylase","crucial role in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitters"]
["lipase 1"]
["acyl-CoA oxidase","fatty acids biosynthesis"]
["lysosomal acid lipase"]
["Putative long-chain acyl-coa synthetase","activates the breakdown of complex fatty acids"]
["ATP-binding cassette sub-family G","white family involved in cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis "]
["carnitine palmitoyltransferase I","Mitochondrial. The carnitine palmitoyltransferase system is an essential step in the beta-oxidation of long chain fatty acids"]
["diacylglycerol O-acyltransferase 1","formation of triglycerids "]
["Long-chain-fatty-acid coa ligase"]
["calcium-independent phospholipase A2-gamma-like"]
["ATP-binding cassette sub-family G member 1 ","involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types"]
["fatty acyl-CoA reductase","catalized the reduction of saturated of fatty acids"]
["Phytanoyl-CoA dioxygenase","required for the alpha-oxidation of branched chain fatty acids in peroxisomes"]
["hormone-sensitive lipase"]
["PI-PLC X domain-containing protein 2","lipid degradation and metabolism"]
["long-chain fatty acid transport protein 4"]
["neutral ceramidase","cleaves fatty acids from ceramide, producing sphingosine"]
["elongation of very long chain fatty acids protein"]
["Peroxisome assembly factor 2","involved in fatty acids catabolism"]
["lipopolysaccharide binding protein"]
["Putative lipoate-protein ligase a"]
["Putative long-chain acyl-coa synthetase","fatty acids metabolism"]
["Lipid storage droplet-1 CG10374-PC"]
["fatty acid synthase"]
["sterol carrier protein x","intracelular lipid transfer"]
["apolipoprotein LI-II precursor "]
["vitellin B"]
["vitellogenin","It is likely that the balance between vitellogenin and juvenile hormone levels is also involved in swarming behavior "]
["long-chain fatty acid transport protein"]
["protein melted-like","fat metabolism"]
["cholesterol transporter"]
["apolipoprotein D"]
["niemann-pick C1","appears to bind to a critical mediator of cholesterol absorption"]
["phospholipase A2D"]
["peroxisomal acyl-coenzyme A oxidase"]
["peroxisomal membrane protein PMP22"]
["peroxisome assembly protein 12-like "]
["peroxisomal membrane protein PEX13"]
["ATP-binding cassette sub-family G member 4 ","white family involved in cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis "]
["short-chain acyl-CoA dehydrogenase "]
["ATP-binding cassette sub-family G member 1 ","white, transport across the membrane"]
["peroxisome assembly factor 2"]
["Choline/ethanolamine kinase","member of the membrane facilitates transport of cholesterol"]
["peroxisomal membrane protein 11B"]
["peroxisomal acyl-coenzyme A oxidase 1"]
["very long-chain specific acyl-CoA dehydrogenase"]
["peroxisomal membrane protein 11B "]
["3-ketoacyl-CoA thiolase","beta oxydation of fatty acids"]
["PREDICTED: glycerol-3-phosphate acyltransferase 3-like isoform 3","glycolipid synthesis"]
["Protein I’m not dead yet","energy metabolism-life span"]
["vitellin-degrading protease"]
["vitellogenin receptor"]
["vitellogenin A"]

{"sheet":"Sugar","index":5,"n_rows":25,"n_cols":2,"rows_kept":25,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["serine dehydratase","gluconeogenesis, high protein diet, starvation"]
["sugar transporter SWEET1"]
["glucose dehydrogenase"]
["facilitated glucose transporter member 5"]
["pyruvate carboxylase","crucial role in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitters"]
["6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase","glycolisis and glycogenesis"]
["similar to sugar transporter"]
["GSK-3-binding protein","glucose homeostasis"]
["D-arabinose 1-dehydrogenase","glucose metabolism"]
["Facilitated trehalose transporter","Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph"]
["UDP-glucose 4-epimerase","glycolysis"]
["UDP-galactose transporter","sugar transport"]
["e3 ubiquitin-protein ligase SMURF2, phosphoglycerate mutase","catalizes step 8 of the glycolysis"]
["Phosphoenolpyruvate carboxykinase","gluconeogenesis"]
["Glycogenin","converts glucose into glucogen"]
["Trehalase","glycoside hydrolase enzyme that catalyzes the conversion of trehalose to glucose"]
["Sugar transporter"]
["6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2-like "]
["Fructose-bisphosphate aldolase "]
["Enolase","glycolysis"]
["glyoxylate reductase/hydroxypyruvate reductase","prevents the buildup of a potentially harmful glyoxylate and can convert hydroxypyruvate to D-glycerate, which is later converted by other enzymes to glucose and used for energy"]
["glucosyl/glucuronosyl transferases"]
["trehalose transporter"]
["triosephosphate isomerase","glycolysis"]

{"sheet":"Mitochondrial","index":6,"n_rows":28,"n_cols":2,"rows_kept":28,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["Mitochondrial NADH dehydrogenase Fe-S protein"]
["NADH dehydrogenase"]
["iron-sulfur protein 5"]
["Thioredoxin-dependent peroxidase","antioxidant"]
["ATP-dependent Clp protease ATP-binding subunit Clpx ","Chaperone, it Participates in the final steps of RseA-sigma-E degradation, liberating sigma-E to induce the extracytoplasmic-stress response"]
["succinyl-coa synthetase","Generation of Nucleoside Triphosphates"]
["peroxiredoxin-6","antioxidant"]
["mitochondrial 50S ribosomal protein L34"]
["Cytochrome c oxidase"]
["glycine dehydrogenase (decarboxylating) mitochondrial-like"]
["mitochondrial cytochrome c oxidase subunit VIa"]
["Succinate dehydrogenase (mitochodria) "]
["Cytochrome c oxidase subunit VB"]
["lipoyltransferase 1 mitochondrial"]
["Ribosomal protein S36, mitochondrial"]
["adenine nucleotide translocase","mitochondrial"]
["cytochrome c oxidase subunit VIIc"]
["Mitochondrial ATP synthase"]
["NADH dehydrogenase 2"]
["mitochondrial ATP synthase lipid-binding protein"]
["ferritin heavy polypeptide-like 17"]
["ADP/ATP translocase"]
["levy, isoform A","cytochrome oxidase activity"]
["mitochondrial dicarboxylate carrier"]
["cytochrome c oxidase assembly protein"]
["metalloendopeptidase OMA1"]
["NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11"]

{"sheet":"Metabolism","index":7,"n_rows":26,"n_cols":2,"rows_kept":26,"flags":["formulas_cached_only"]}
["metabolism"]
["Gene","Reason why selected"]
["Pyruvate dehydrogenase","glycolysis, citric cycle, asociated to Acetyl CoA"]
["major facilitator superfamily transporter 16","sugar and small molecul transport"]
["very long-chain-fatty-acid--CoA ligase bubblegum","plays a central role in brain very long-chain fatty acids metabolism and myelinogenesis"]
["serine palmitoyltransferase","The first step in the biosynthesis of sphingolipids"]
["lipoyltransferase 1","participates in lipoic acid metabolism. Lipoic acid is essential for aerobic metabolism"]
["N-acetylglucosamine-6-phosphate deacetylase","metabolism of the amino sugars"]
["phospholipid hydroperoxide glutathione peroxidase","glutathione metabolism"]
["ATP synthase"]
["glutamine synthetase 2","metabolic regulation of glutamate, the detoxification of brain ammonia, the assimilation of ammonia, recyclization of neurotransmitters, and termination of neurotransmitter signals"]
["glutamate synthase"]
["Nucleoside-diphosphate kinase"]
["organic cation transporter"]
["Acetylcholinesterase","hydrolyzes the neurotransmitter acetylcholine "]
["Neprilysin","membrane zinc-dependent metallo-endopeptidase that cleaves and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease "]
["HIG Hypoxia inducible domain family, member 1A","neuronal responds to low glucose levels, hypoxia and implicated in apoptosis"]
["lysosomal protein NCU-G1-A"]
["Aquaporin","Integral membrane pore proteins that selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Those known as aquaglyceroporins also transport other small uncharged solutes, such as glycerol, CO2, ammonia and urea"]
["H+ transporting ATP synthase"]
["Abc transporter"]
["d-3-phosphoglycerate dehydrogenase"]
["Adenylate cyclase","conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP"]
["Gamma-glutamyl phosphate reductase","urea cycle and metabolism of amino groups"]
["uricase","catalyzes the oxidation of uric acid to 5-hydroxyisourate"]
["Regucalcin","Regucalcin has a suppressive effect on calcium signaling from the cytoplasm to the nucleus"]

{"sheet":"Detoxification","index":8,"n_rows":50,"n_cols":2,"rows_kept":50,"flags":["formulas_cached_only"]}
["Detoxification"]
["Gene","Reason why selected"]
["ABC transporter effluxers","regulation of opening and closing of ion channels carried by the ABC protein itself or other proteins, protect against xenobiotics "]
["cytochrome P450 monooxygenase"]
["cytochrome P450 Cyp6b29"]
["Probable cytochrome P450 6a13"]
["cytochrome P450 4aa1-like"]
["cytochrome P-450"]
["cytochrome P450 6AQ5"]
["Cytochrome P450 4g15"]
["Cytochrome P450 CYP4C62"]
["multidrug resistance-associated protein 4"]
["sterol O-acyltransferase 1","prevents accumulation of toxic cholesterol"]
["esterase FE4","insecticide resistance"]
["Putative phosphatidylinositol transfer protein pdr16 ","drug resistance, azole resistance in fungi"]
["mutt/nudix hydrolase","cleansing: hydrolyse intracellular nucleotides and so regulate their levels and eliminate potentially toxic derivatives"]
["cytochrome P450 CYP4G17"]
["cytochrome P450 4G43"]
["secreted carbonic anhydrase","Ph control"]
["cytochrome P450 CYPm3r10"]
["Cytochrome P450 4g15"]
["cytochrome P450 6k1"]
["cytochrome P450 CYP4G25 "]
["multidrug resistance-associated protein lethal(2) ","ABC transporter"]
["cytochrome P450 4c3-like "]
["cytochrome P450 6BK5"]
["cytochrome P450 49a1"]
["carboxylesterase-6","participates in the metabolism of drugs and toxins including xenobiotics"]
["Glutathione s-transferase M2","detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione "]
["Multidrug resistance-associated protein 4"]
["microsomal glutathione S-transferase-like","detoxification of the cellular environment"]
["valacyclovir hydrolase"]
["multidrug resistance protein homolog 49"]
["alcohol dehydrogenase","detoxification"]
["cytochrome P450 CYP6BK17"]
["scavenger receptor","participate in the removal of many foreign substances and waste materials in the living body by extensive ligand specificity and a variety of receptor molecules"]
["cytochrome P450 4g15-like"]
["cytochrome P450 9Z4,"]
["carboxylesterase","metabolism of xenobiotics"]
["cytochrome P450 304a1"]
["esterase FE4","insectiside resistance, detoxification"]
["Microsomal glutathione S-transferase","detoxificaion, oxydative stress"]
["glutathione S-transferase D24"]
["multidrug resistance-associated protein 4"]
["Multi drug resistance 50 "]
["cytochrome P450 CYP15A1","produced in corpora allata and produces juvenil hormone III"]
["Alpha-esterase"]
["ATP-binding cassette transporter subfamily G member Bm3","functions as a xenobiotic transporter"]
["epoxide hydrolase","It converts epoxides to trans-dihydrodiols and functions in detoxification "]
["Aldo-keto reductase"]

{"sheet":"Cell death","index":9,"n_rows":18,"n_cols":2,"rows_kept":18,"flags":["formulas_cached_only"]}
["Cell death"]
["Gene","Reason why selected"]
["death-associated small cytoplasmic leucine-rich protein SCLP","autophagy and apoptosis"]
["Croquemort","Required for phagocytosis of apoptotic cells in Drosophila"]
["apoptosis-inducing factor 3"]
["caspase-8"]
["cell division cycle and apoptosis regulator protein 1 "]
["Fas (TNFRSF6)-associated via death domain","necroptosis, apoptosis and autophagy"]
["Diablo","This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis"]
["autophagy-related protein 101"]
["autophagy-related protein 2 homolog"]
["Bax Inhibitor-1 (BI-1)","evolutionary conserved endoplasmic reticulum (ER)-located protein that protects against ER stress-induced apoptosis"]
["Alsin","motor neuron degeneration"]
["Dronc","the only fly caspase known to be regulated by the hormone ecdysone, Juvenile hormone esterase binding protein 29"]
["serine/threonine-protein kinase"]
["factor associated with neutral sphingomyelinase activation"]
["clustrin-associated protein","apoptosis"]
["PREDICTED: sphingomyelin synthase-related 1-like","primary role in monitoring ER ceramide levels to prevent inappropriate cell death during sphingolipid biosynthesis"]

{"sheet":"Defense and immunity","index":10,"n_rows":51,"n_cols":2,"rows_kept":51,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["cysteine-rich/pacifastin venom protein 1","defense"]
["Defensin-1","immunity "]
["serine protease inhibitor I","serpin I, innate immune response"]
["Serine protease inhibitor I/II"]
["pacifastin-related precursor 4a"]
["pacifastin-related peptide precursor PP-5"]
["Serine protease inhibitor 3"]
["serine protease P43","immunity"]
["pacifastin-related serine protease inhibitor precursor"]
["serine protease P15"]
["PREDICTED: venom allergen 5-like"]
["Diptericine"]
["pellino","scaffold protein, innate immune signaling pathway, Toll like receptor"]
["serine/threonine-protein kinase TBK1","Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components"]
["Immune responsive gene 1 (IRG1)","immune system, promotes endotoxin tolerance, and seems to link metabolism to immunity"]
["Nuclear factor related to kappa-B-binding protein","transcription in response to stress, cytokins and free radicals, plays a rol in immune response to infection"]
["MPA13 allergen"]
["similar to plasma PAF "]
["acetylhydrolase"]
["Ves G 1 allergen"]
["peptidoglycan recognition protein","immune recognition of pathogens"]
["Leucine-rich repeat-containing protein 20","associated with autoimmune desease "]
["Lysozyme","immune system antimicrobial"]
["catrin","venom "]
["diptericin","immune response"]
["serpin 5","immune response"]
["serine protease homolog 21","immune response"]
["pro-phenoloxidase","forms part of a modified form of the complement response found in some invertebrates, where a major innate defense system is the melanization of pathogens and damaged tissues. This important process is controlled by the enzyme phenoloxidase. THIS, IN TURN, IS THIGHTLY CONTROLED BY A CASCADE OF SERINE PROTEINASES AND PROTEINASES INHIBITORS—also overexpressed here "]
["NF-kappa-B-repressing factor","innate immune response"]
["toll","involved in the dosrsal ventral axis patterning, immune system—antifungi, and the formation of melanotic capsules as an immune response"]
["Ves G 5 allergen"]
["Peptidoglycan recognition protein long class","antibacterial"]
["Ferritin heavy chain","immune response, stress"]
["Interferon regulatory factor 2-binding protein 2-B","immune response"]
["mannan-binding lectin serine protease 1-like","immune system "]
["lipopolysaccharide-induced tumor necrosis factor-alpha","antiinflamatory, immune system"]
["FAM64A","immune response"]
["nimrod","immune response "]
["pro-phenoloxidase 2","parasite melanization"]
["nuclear factor NF-kappa-B p100 subunit","controls transcription and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens-- plays a key role in regulating the immune response to infection"]
["phenoloxidase","immunity, melanization"]
["melanization protease 1"]
["serine protease inhibitor I "]
["Relish","immune response"]
["cysteine-rich/KU venom protein"]
["venom carboxylesterase-6"]
["pacifastin-related peptide"]
["serine protease inhibitor 3/4 "]
["gamma-interferon-inducible lysosomal thiol reductase","response to bacterial infection"]
["PREDICTED: similar to trypsin-like serine protease"]

{"sheet":"other","index":11,"n_rows":12,"n_cols":2,"rows_kept":12,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["translin","Recombination (gregarious locusts have increased chiasma frequencies)"]
["similar to PiggyBac transposable element-derived protein 4, "]
["minos transposase"]
["endonuclease-reverse transcriptase "]
["DNA-mediated transposase "]
["mariner transposase "]
["non-LTR retrotransposon RTE sequence"]
[]
[]
[]
[" "]

{"sheet":"Sensorial","index":12,"n_rows":36,"n_cols":6,"rows_kept":36,"flags":["formulas_cached_only"]}
["Sensorial"]
["Chemosensory",null,"mechanosensory",null,"sight"]
["Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected"]
["LmigCSP3",null,"No-mechanoreceptor potential A, putative"]
["CSP11",null,"hemicentin-1","A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes including anchorage of mechanosensory neurons to the epidermis","class A rhodopsin-like G-protein coupled receptor GPRnna17"]
["Schistocerca gregaria chemosensory protein CSP-sg4 (schi-10)",null,"hemicentin","anchorage of the mechanosensory neurones to the epidermis","class A rhodopsin-like G-protein coupled receptor GPRnna14"]
["chemosensory protein 4",null,"serine proteinase stubble","involved in bristle formation","PREDICTED: opsin, blue-sensitive-like"]
["chemosensory protein 18",null,"groucho","neurogenic and bristle associated","class A rhodopsin-like G-protein coupled receptor GPRpgn putative"]
["chemosensory protein 17",{"$nulls":3},"eye-specific protein kinase C","light adaptation"]
["chemosensory protein OS-D3 gene",{"$nulls":3},"liquid facets ","eye development and function"]
["OS-D-related chemosensory protein",{"$nulls":3},"cellular retinaldehyde binding protein (CRALBP)","reaction of the visual cycle, mutation results in delayed reaction to dark after illumination"]
["CSP precursor",{"$nulls":3},"beta-carotene 15,15'-monooxygenase","production of retinoids, works with opsin"]
["chemosensory protein 12",{"$nulls":3},"steroid receptor seven-up","required to specify the photoreceptore neuron subtypes"]
["Odorant receptor, putative",{"$nulls":3},"retinal protein"]
["Ataxin 2 homolog","required for microRNA function and synapse-specific long-term olfactory habituation",null,null,"Opsin blue sensitive"]
["chemosensory protein 13",{"$nulls":3},"rhodopsin-specific isozyme"]
["CSP-sg3",{"$nulls":3},"retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase"]
["Cspsg4",{"$nulls":3},"photoreceptor-specific-like"]
["chemosensory protein CSP-sg5, ",{"$nulls":3},"unc119","localizes to the photoreceptor synapses where it plays a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle"]
["chemosensory protein 2",{"$nulls":3},"PREDICTED: similar to small optic lobes CG1391-PB"]
["Schistocerca gregaria chemosensory protein CSP-sg2 (schi-4)",{"$nulls":3},"crumbs","In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye"]
["antennal carrier protein TOL-2","Odor detection"]
["odorant-binding protein 8"]
["Ejaculatory bulb-specific protein 3 also called Insect odorant-binding protein A10","involved in behaviour control"]
["odorant-binding protein 2b"]
["mutant chemosensory protein 1 variant"]
["odorant-binding protein 4"]
["chemosensory protein 14"]
["chemosensory protein 19"]
["Schistocerca gregaria antennal-specific protein mRNA"]
["odorant-binding protein RpalOBP4"]
["chemosensory protein 5"]
["OBP11"]
["antennal CSPSgre-III-1"]
["OBP7 protein"]
["PREDICTED: similar to defective proboscis extension response putative","gustatory aversion to salt in drosophila"]

{"sheet":"Signaling","index":13,"n_rows":27,"n_cols":2,"rows_kept":27,"flags":["formulas_cached_only"]}
["Signaling"]
["Gene","Reason why selected"]
["calcium/calmodulin-dependent protein kinase kinase","CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory"]
["protein enhancer of sevenless 2B","required for proper signaling by sevenless which is a protein essential to the development of R7 cells in the Drosophila embryonic eye"]
["Ras GTPase-activating protein","crucial for the control of the G-protein activity "]
["guanine nucleotide-binding protein","G protein"]
["inositol 1,3,4-triphosphate 5/6 kinase","involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels"]
["arylsulfatase J","hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules"]
["PREDICTED: similar to regulator of g protein signaling, ift57/hippi/che-13, putative"]
["PREDICTED: probable G-protein coupled receptor B0563.6-like"]
["GTPase-Activating Proteins","regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event"]
["guanine nucleotide-binding protein G(q) subunit alpha","cell signaling"]
["Geranylgeranyl transferase","cell-cell signaling"]
["G-protein signaling modulator"]
["phosphatidate cytidylyltransferase"]
["ryanodine receptor-like"]
["methuselah-like protein 10","GPcr"]
["methuselah"]
["G-protein coupled receptor Mth2"]
["similar to parathyroid hormone receptor "," GPCR with a role in the control of the calcium and are critical controllers of calcium and phosphorus balance"]
["ryanodine receptor 44F, "]
["G protein alpha q isoform 1"]
["TBC1 domain family member 16","RAB GTPase signaling and vesicle trafficking"]
["leucine rich repeat G protein coupled receptor"]
["inositol oxygenase ","part of the only known pathway for the catabolism of inositol. Involved in cell-signaling inositol, Nerve guidance (epsin), Cytoskeleton assembly, Intracellular calcium (Ca2+) concentration control, Cell membrane potential maintenance"]
["myoinositol oxygenase ","see inositol oxygenase "]
["PREDICTED: beta-2 adrenergic receptor-like"]

{"sheet":"Hormone_related","index":14,"n_rows":11,"n_cols":2,"rows_kept":11,"flags":["formulas_cached_only"]}
["Gene","Reason why selected"]
["Prothoracicostatic peptide ","neuropeptide involved in regulating steroid hormones and ecdysteroidogenesis"]
["PREDICTED: nuclear receptor-binding protein homolog","nuclear receptors bind to DNA and regulate gene expression, they are a class of signal transducers that sense steroid and thyroid hormones and certain other molecules"]
["Steroid receptor seven-up, isoform A"]
["Steroid dehydrogenase, "]
["ecdysteroid regulated 16 kDa"]
["NADP+-dependent farnesol dehydrogenase 1","plays a key rol in Juvenile hormone synthesis. The balance between vitellogenin and juvenile hormone levels seem involved in the swarming behavior."]
["Farnesoic acid O-methyltransferase ","Key enzyme in the juvenile hormone biosynthetic pathway (Methyl farnesoate is the crustacean analogue of the insect juvenile hormone III)"]
["Juvenile hormone-inducible protein"]
["high affinity nuclear juvenile hormone binding protein"]
["Juvenile hormone epoxide hydrolase-like protein 5 "]

{"sheet":"Stress","index":15,"n_rows":24,"n_cols":2,"rows_kept":24,"flags":["formulas_cached_only"]}
["stress"]
["Gene","Reason why selected"]
["10 kDa heat shock protein"]
["heat shock protein 70"]
["stress protein DDR48-like"]
["heat shock protein 20.5"]
["cap'n'collar","stress activated, detoxification, regulates glutathione biosynthetic enzymes, involved in life span and aging"]
["Heat shock 70 kDa protein cognate"]
["N-myc downstream-regulated gene 3 protein","stress and hormone responses"]
["Methuselah","GPCR, stress resistance, development, lifespan"]
["Nuclear factor related to kappa-B-binding protein","transcription in response to stress, cytokins and free radicals, plays a rol in immune response to infection"]
["apolipoprotein D","Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan"]
["neutral ceramidase","cleaves fatty acids from ceramide, producing sphingosine which forms a primary part of sphingolipids that strengthen the cell membrane and provide protection to the cell from damaging extracellular agents. Form part of the apoptosis, response to stress and inflamation"]
["Taurine catabolism dioxygenase TauD","possible role in antianxiety"]
["vascular endothelial growth factor A-A","related to stress and hypoxia"]
["G-protein coupled receptor Mth2","Methuselah-2 involved in aging and stress response"]
["Heat shock 70 protein cognate 3","protein folding and cell response to stress"]
["HIG1 domain family member 2A","stress, hypoxia"]
["Hsp60 protein"]
["stress-induced-phosphoprotein 1","interacts with Hsps (70) in stress response"]
["heat shock protein 75"]
["PREDICTED: oxidative stress-induced growth inhibitor 1-like"]
["methuselah-like protein 10"]
["SAGA-associated factor 11 homolog","Dual role in ER Stress survival by coordination of Histone H3 Acetylation and Histone H3 Lysine-4 Trimethylation "]

{"sheet":"CNS genes","index":16,"n_rows":90,"n_cols":10,"rows_kept":90,"flags":["formulas_cached_only"]}
["Neural-related conditions",null,"Development, ventralization and neural maintenance",null,"neural funcion",null,"Regulation of neural function",null,"neural plasticity"]
["Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected"]
["proteasome zeta","involved in neural degenaration in fetal down syndrom","spaezle","toll related, morphology, ventralization","synaptic vesicular amine transporter",null,"Septin-4","its overexpression negatively affects dopaminergic neurons","protein kibra","synaptic plasticity"]
["Down syndrome cell adhesion molecule-like protein CG42256-like",null,"Vrille","ventralization","alpha-L1 nicotinic acetyl choline receptor",null,"Glutathione s-transferase d1","GSTD1, its increased activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson´s disease","small bristles","path finding"]
["AMME syndrome candidate gene 1 protein","mental retardation ","survival motor neuron protein",null,"nicotinic acetylcholine receptor subunit a5",null,"nose resistant to fluoxetine","fluoxetine sensitivity, prevents reuptake of serotonin, antidepressant","longitudinals lacking","axon guidance and positioning of the chordotonal organs"]
["St7 protein","autism","14-3-3 protein zeta","Predominantly expressed in the ventral nerve cord of the embryo, and in the neural tissues of the head. Also found in the region posterior to the morphogenetic furrow of the eye imaginal disk where cells differentiate as photoreceptors","veli","regulation of synaptic growth at neuromuscular junction","neuropeptide receptor A27",null,"Fasciclin-3","axon pathfinding"]
["fragile X mental retardation syndrome-related protein 1","found in dendrites, its mutation result in abnormal branching, fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses","Spindle F","ventralization, abnormal bristles","rho-type guanine Exchange","important for the targeting or synaptic stabilization of at least three major synaptic proteins: Pak kinase, Dlg, and GluRIIA","PREDICTED: nose resistant to fluoxetine protein 6-like",null,"Scribble","Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein, neural diferenciation"]
["lupus la ribonucleoprotein","decreased in down syndrome","nanos","control the elaboration of high-order dendritic branches of class III and IV and Several recent findings implicate nanos and pumilio in eye development, optic nerve development, neuronal excitability, and long-term memory","rabconnectin","small G protein family, regulates Ca2+-dependent exocytosis of neurotransmitter","macoilin-1","CNS-specific and regulates neuronal exitability—defects in aggregation C. elegans","catenin delta-2","expressed in the brain  and seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory"]
["AP-5","spastic paraplejia","Short gastrulation SOG","dorsal ventral patterning","organic cation transporter protein","transport of neurotramitters, drug absorption and elimination","succinate-semialdehyde dehydrogenase","related to GABA and glutamate pathways","semaphorin 2a","chemorepulsive guidance molecule critical for axon fasciculation and for determining both the initial direction and subsequent pathfinding events of axon projection"]
["jerky protein","epileptic seizures, hypocampus atrophy","saxophone protein","interacts with dpp, ventralization","Clavesin-2","expressed exclusively in neurons, this protein appears to provide a unique neuron-specific regulation of late endosome/lysosome morphology",null,null,"supervillin","involved in actin filament assembly at adherens junctions and plays additional roles in other cellular compartments and in neuron sprouting "]
["Epsilon-trimethyllysine 2-oxoglutarate dioxygenase","mitochondrial, associated with autism","Neurofilament triplet M protein","They are a major component of the neuronal cytoskeleton, and are believed to function primarily to provide structural support for the axon and to regulate axon diameter","synaptosomal-associated protein 29","involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane",null,null,"kakapo","its mutation affects terminal arborization and central dendritic sprouting"]
[" zinc finger protein 395","known in humans as Huntington disease gene regulatory region-binding protein 2","lethal(2)","affects cell growth and cell adhesion properties of neural and imaginal disc cells during embryonic and larval development","Synaptophysin","synaptic transmission",null,null,"Rho GTPase-activating protein 6","play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling"]
["huntingtin-interacting protein 1",null,"serine/threonine-protein kinase Doa-like","required for development of the nervous system and has a critical function for Drosophila eye development, the organization and development of pigment cells, bristles, and photoreceptors","excitatory amino acid transporter","nerotransmitter transporter serve to terminate the excitatory signal by removal (uptake) of glutamate from the neuronal synapse into neuroglia and neurons",null,null,"fasciculation and elongation protein zeta-2-like","ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles"]
["NPC2","This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease and frontal lobe atrophy in humans","bric-A-brac","antena and leg development, bristles and pigmentation among others","ankyrin-3","specifically localized to the neuromuscular junction, the axon initial segment and the Nodes of Ranvier. Required for the normal clustering of voltage-gated sodium channels at the axon hillock and for action potential firing ",null,null,"slit homolog2","axon guidence"]
["jerky protein","mutations cause epilepsy ","divergent antennapedia-class homeodomain protein","has a role in CNS development ","pyruvate carboxylase","crucial role in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitters",null,null,"Rho family small GTP binding protein cdc42","The members of the Rho GTPase family regulate many aspects of intracellular actin dynamics"]
["Cereblon","binds to and regulates the activity of the large-conductance calcium-activated potassium channel. Its defect is associated with neurological disorders and mental retardation in human","serrate RNA effector molecule","miRNA processing and is necessary and sufficient to promote neural stem cell self-renewal","Chromaffin granule amine transporter","integral membrane protein embedded in synaptic vesicles. Transfers monoamines, including norepinephrine, dopamine and serotonin between the cytosol and the synaptic vesicles. ",null,null,"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, testin protein","cells that have impaired TES expression show inability to correctly organize their focal adhesions and actin stress fibres"]
["Neprilysin","zinc dependent membrane metallo-endopeptidase that inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide and prevents its abnormal misfolding and aggregation in neural tissue (implicated in Alzheimer's disease)","bunched","involved in eye development, tissue patterning, apoptosis and locomotion among other involvements","trafficking kinesin-binding protein milt","Required for kinesin-mediated axonal transport of mitochondria to nerve terminals","protects proteins from irreversible aggregation under cellular stress",null,"f-spondin","axon guidance"]
[null,null,"fusilli","palys a rol in dorsal-ventral patterning possibly through RNA splicing","Spectrin","affects neuronal outgrouths, neurotransmission at the neuromuscular junction and the animals coordination—paralysis",null,null,"MICAL (molecule interacting with CasL)","conserved family of cytosolic multidomain proteins associated with a variety of cellular processes, including axon guidance, cell movement, cell-cell junction formation and vesicle trafficking"]
[null,null,"toll","involved in the dosrsal ventral axis patterning, immune system—antifungi, and the formation of melanotic capsules as an immune response","alpha/gamma/epsilon","mediates the formation of visicles",null,null,"slit"]
[null,null,"Chaoptin","photoreceptor cell-specific membrane protein plays a critical role in photoreceptor cell morphogenesis and microviliar organization","cysteine-rich motor neuron",{"$nulls":3},"microtubule-associated protein futsch-like"]
[null,null,"roadkill","involved in eye development","annexins","involved in membrane scaffolding, organization and trafficking, play a role in the exocytotic pathway, specifically in the later stages near or at the plasma membrane",null,null,"ephrin receptor","implicated in cell-cell signaling and several developmental processes including axon guidence"]
[null,null,"Dorsal","dorso-ventral axis and immunity through activation of the antifungal Drosomycin through the Toll pathway","vacuolar protein sorting-associated protein 13C",{"$nulls":3},"Rho GTPase-activating protein 21","regulates actin dynamics and involved in the Morphogenesis and plasticity of Dendritic Spines"]
[null,null,"hunchback","essential for neuron development","Putative endocytic adaptor protein intersectin","important at synapses",null,null,"matrix metalloproteinase 1"]
[null,null,"sidekick","required for pattern formation in the Drosophila eye","Dihydropyridine-sensitive l-type calcium channel","neuronal exitability",null,null,"LAG1 longevity assurance","important for the synthesis of myelin sphingolipids"]
[null,null,"numb","sensory neurons specification","vacuolar protein sorting-associated protein 29",{"$nulls":3},"phosphatidylcholine:ceramide cholinephosphotransferase","related to the shingomyelin synthesis"]
[null,null,"abrupt","required for the embryonic formation of specific synaptic connections at the neuromuscular junction between a subset of motorneurons and a corresponding subset of muscles. abrupt also has a role in establishing and maintaining muscle attachments, adult sensory cell formation and morphogenesis of adult appendages","UPF0183 protein","glutamate receptor binding",null,null,"Ephrin type-B receptor","involved in axon guiding in the mushroom bodie, known to play a role in olfactory learning and memory"]
[null,null,"Optineurin","interacts with Huntingtin and RAB8A","PREDICTED: similar to serotonin receptor putative",{"$nulls":3},"Transforming acidic coiled-coil-containing protein 1","microtubule interacting "]
[null,null,"Meteorin","plays important roles in both glial cell differentiation and axonal network formation during neurogenesis ","transmembrane protein 135-like isoform X1","peroxisome organization ",null,null,"Spectrin beta chain","is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape "]
[null,null,"E3 ubiquitin-protein ligase suppressor of deltex","delex interacts with notch and Deltex-dependent pathway represses neural fate","Homogentisate 1,2-dioxygenase","catalyzes the conversion of homogentisate to 4-maleylacetoacetate. Homogentisate 1,2-dioxygenase or HGD is involved in the catabolism of aromatic rings, more specifically in the breakdown of the amino acids tyrosine and phenylalanine. Homogentisate when oxidized by the body will produce the compound known as the ochronotic pigment, which causes a black color. it is also involved in the synthesis of hormones and neurotransmitters ",null,null,"disintegrin and metalloproteinase domain-containing protein 10","path finding"]
[null,null,"Spitz","involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development","Endophilin-A","synaptic vesicle endocytosis",null,null,"LIM protein","actin and cytoskeletal organization"]
[null,null,"Van Gogh ","essential for frizzled signaling, its mutation produces abnormal bristle and ommatidia orientation--involved in cell polarity","protein kintoun","Required for cytoplasmic pre-assembly of axonemal dyneins",null,null,"dynein heavy chain","axonemal, associated with microtubules where it plays a minus-end directed motor function and causes microtubule sliding"]
[null,null,"serine protease easter","ventralization","JNK-interacting protein 3","direct mediator of dynein-based retrograde axonal transport of activated (phosphorylated) c-Jun N-terminal Kinase (JNK) and lysosomes",null,null,"microtubule-associated protein futsch"]
[null,null,"Serine/threonine-protein kinase Doa","required for development of the nervous system and has a critical function for Drosophila eye development, the organization and development of pigment cells, bristles, and photoreceptors","exocyst complex component 3","involved in the docking of exocytic vesicles with fusion sites on the plasma membrane",null,null,"tubulin-folding cofactor B, "]
[null,null,"cubitus interreptus","required for Hedgehog signaling","vacuolar protein sorting-associated protein 45",{"$nulls":3},"Rho GTPase regulating protein","involved in cell skeleton "]
[null,null,"Homothorax","CNS developement","Connector enhancer of kinase suppressor of ras 3","function in bringing together the Ras signalling complex at the post synaptic density",null,null,"RalA","plays a significant role in filopodia formation and activity-dependent growth of postsynaptic membranes"]
[null,null,"PREDICTED: RING finger protein unkempt homolog","Unkempt uncouples neuronal differentiation from growth control","Chloride intracellular channel 6-like","in addition to its role in the chloride channel, it interacts with Dopamine receptor D3",null,null,"Nardilysin","regulates axonal maturation and myelination in the central and peripheral nervous system"]
[null,null,"tyrosine-protein phosphatase corkscrew","component of the Ras signaling pathway. Functions in the development of ventral cell fate","charged multivesicular body protein 6-like",{"$nulls":3},"protein phosphatase Slingshot","plays a rol in actin dynamics"]
[null,null,"enhancer of split","regulate neurogenesis and related differentiation pathways","charged multivesicular body protein 7-like isoform 2 ",{"$nulls":3},"contactin-5","synapses formation"]
[{"$nulls":4},"neurotrypsin","synaptic and associated with neuronal plasticity",null,null,"Rho GTPase-activating proteins","one of the major classes of regulators of Rho GTPases found in all eukaryotes that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions"]
[{"$nulls":4},"ras guanine nucleotide exchange factor P-like","involved in essential cell processes such as cell differentiation and proliferation, cytoskeletal organization, vesicle trafficking, and nuclear transport",null,null,"serine/threonine-protein kinase tricorner","Has an important role in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons"]
[{"$nulls":4},"protein sidekick-1 ","synapse",null,null,"hyccin-like","hyccin protein family may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system"]
[{"$nulls":4},"Annexin IX","Annexins are important for membrane scaffolding, changes in the cell's shape, trafficking and organization of vesicles, exocytosis, endocytosis and calcium ion channel formation",null,null,"Spastin","serves microtubules, essential to axons "]
[{"$nulls":4},"Calsyntenin-1","multi-purpose functions both within and outside the nervous system, it regulates postsynaptic calcium concentration",null,null,"sorbin and SH3 domain-containing protein 2","important for lipid rafts that mediate signals important for actin reorganization in growing neurites"]
[{"$nulls":4},"glutamate receptor Gr1","sensory neurones",null,null,"tyrosine-protein phosphatase 10D","axon guidance"]
[{"$nulls":4},"Gephyrin","a component of the postsynaptic protein network of inhibitory synapses. It also regulates the formation and plasticity of GABAergic synapses by altering the clustering properties of postsynaptic scaffolds and thereby the availability and function of receptors and other signalling molecules ",null,null,"Stathmin","microtubule organization, associated with social behavior"]
[{"$nulls":4},"Rab4","G-protein. Rab GTPases regulate many steps of membrane traffic, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion",null,null,"turtle","dendrite growth, branching and same-neuron self-avoidance"]
[{"$nulls":4},"synaptic vesicle membrane protein VAT-1",{"$nulls":3},"disco-interacting protein","May provide positional cues for axon pathfinding and patterning in the central nervous system."]
[{"$nulls":4},"Huntingtin","primarily associated with vesicles and microtubules",null,null,"Fasciclin-1","path finding"]
[{"$nulls":4},"huntingtin-interacting protein 1 isoform 2",{"$nulls":3},"microtubule-actin cross-linking factor 1"]
[{"$nulls":4},"H(+)/Cl(-) exchange transporter 3","Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis",null,null,"Neurexins","components of septate junctions playing a role in cell adhesion; they are components of synapses, playing a potential role in axon guidance and innervations"]
[{"$nulls":4},"synaptobrevin","exocytosis ",null,null,"Homer","part of a mechanism of homeostatic plasticity that dampens the neuronal responsiveness when input activity is too high, plays a role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation."]
[{"$nulls":4},"carboxypeptidase D","biosynthesis of neuropeptides and peptide hormones",null,null,"synaptojanin-1","nuron development and extention"]
[{"$nulls":4},"Dynamins","GTPases that are essential for clathrin-coated vesicle formation during receptor-mediated endocytosis",null,null,"Flotillin","cytoskeleton"]
[{"$nulls":4},"synaptogyrin-1","integral membrane protein associated with presynaptic vesicles in neuronal cells probably involved in synaptic plasticity ",null,null,"F-actin-capping protein"]
[{"$nulls":4},"nicotinic acetylcholine receptor","synaps, neuromuscular synaps stimulation",null,null,"dunce","learning and memory, positive control of fasciclin, rol in axonogenesis"]
[{"$nulls":4},"roadblock","axonal transport",null,null,"Multiplexin","motor neuron path finding"]
[{"$nulls":4},"Scribble","SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization ",null,null,"innexin","member of a family of proteins that create gap junctions in invertebrates"]
[{"$nulls":4},"Cathepsin B","break down the proteins that cause amyloid plaque",null,null,"Teneurins","promote neurite outgrowth and cell adhesion. The knockdown of teneurin (ten-1) expression in C. elegans with RNAi leads to abnormal neuronal pathfinding"]
[{"$nulls":4},"glutamate receptor",{"$nulls":3},"neuronal growth regulator 1"]
[{"$nulls":4},"Peptidyl-glycine alpha-amidating monooxygenase","This gene encodes a multifunctional protein involved in the catalysis of neuroendocrine peptides to active alpha-amidated products ",null,null,"fasciclin 2","neuronal fasciculation"]
[{"$nulls":4},"annexin","visicule transport, membrane folding, anti-inflamatory responses",null,null,"fasciclin-3","axon pathfinding"]
[{"$nulls":4},"Rab-11A","The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes",null,null,"shootin-1","neuron axon polarization"]
[{"$nulls":4},"unkempt","CNS specific ",null,null,"SLIT-ROBO Rho GTPase-activating protein","axon guidance"]
[{"$nulls":4},"unc13","involved in GABAergic and cholinergic synapses, UNC-13 mediates either fusion of vesicles during exocytosis or priming of vesicles for fusion ",null,null,"twinstar","budding new presynaptic varicosities over the course of minutes in response to elevated neuronal activity"]
[{"$nulls":4},"hamartin","vesicular transport, neuroprotection, autophagy",null,null,"Semaphorin","axonal growth cone guidance molecules"]
[{"$nulls":4},"calcium release-activated calcium channel protein 1","ER"]
[{"$nulls":4},"sodium-potassium-chloride cotransporter","responses to the neurotransmitters GABA"]
[{"$nulls":4},"transmembrane protein 16E"]
[{"$nulls":4},"ion transport peptide isoform B"]
[{"$nulls":4},"Ankyrin 2","cytoskeleton, positioning of membrane proteins and channels"]
[{"$nulls":4},"ankyrin repeat domain-containing protein 39-like isoform 3 "]
[{"$nulls":4},"Ankyrin 2,3/unc44"]
[{"$nulls":4},"ankyrin repeat-containing protein"]
[{"$nulls":4},"adaptin","formation of visicules"]
[{"$nulls":4},"ankyrin-1"]
[{"$nulls":4},"tubulin-specific chaperone e","neuro-muscular synapse"]
[{"$nulls":4},"proton-coupled amino acid transporter 1"]
[{"$nulls":4},"sodium-dependent phosphate transporter"]
[{"$nulls":4},"AP2-associated protein kinase 1-like","receptor-mediated endocytosis"]
[{"$nulls":4},"Solute carrier family 2"]
[{"$nulls":4},"clavesin-1-like","Required for normal morphology of late endosomes and/or lysosomes in neurons "]
[{"$nulls":4},"VPS9-ankyrin repeat-containing protein","required for endosome and export to the cell surface (regulates the trafficking of melanogenic enzymes)"]
[{"$nulls":4},"histidine decarboxylase ","neurotransmission"]
[{"$nulls":4},"CREB 8 protein","cAMP response element-binding protein. Involved in neuron survival, long term memory, drug adiction, and long term potentiation. It regulates the transcription of genes such as c-fos, the neurotrophin BDNF (brain-derived neurotrophic factor), tyrosine hydroxylase, many neuropeptides as well as genes involved in the mammalian circadian clock. Involved in Huntington's disease."]
[{"$nulls":4},"acetylcholinesterase-1 "]
[{"$nulls":4},"PREDICTED: glutamate receptor delta-2 subunit-like","member of the ionotropic glutamate receptors family which are the predominant excitatory neurotransmitter receptors"]
[{"$nulls":4},"Ca2+-channel-protein-beta-subunit, isoform H"]
[{"$nulls":4},"PREDICTED: neural-cadherin"]
[{"$nulls":4},"cadherin-N"]
[{"$nulls":4},"Rab-1A ","Ras-related small GTPase involved in vesicular protein transport in the early secretory pathway, in the subcellular distribution and function of the angiotensin II type 1A receptor, beta2-adrenergic receptor, and alpha2B-adrenergic receptor."]

{"sheet":"Behaviour","index":17,"n_rows":24,"n_cols":2,"rows_kept":24,"flags":["formulas_cached_only"]}
["behaviour"]
["Gene","Reason why selected"]
["protein takeout","takeout mutant has aberrant locomotor activity and dies rapidly in response to starvation, indicating a link between locomotor activity, survival, and food status. It is proposed that takeout participates in a novel circadian pathway target that conveys temporal and food status information to feeding-relevant metabolisms and activities"]
["circadian clock-controlled protein-like"]
["HERC2","hyperactivity"]
["cryptochrome-1","blue light sensitive, circadian rhythm, sensing of magnetic fields"]
["Peroxiredoxin","circadian cloc, signal transc¡duction"]
["timeless","circadian rythm"]
["major royal jelly protein 4","the Major Royal Jelly Protein (MRJP) family relate to yellow and is required for all major aspects of eusocial behavior"]
["Period circadian protein"]
["astakine","belongs to a prokineticin superfamily of proteins that link melatonin to direct regulation of the core circadian clock gene feedback loops"]
["yellow h","melanin biosynthesis, behavior including sexual, learning and foraging"]
["yellow e3-like"]
["Nocturnin","circadian, increased at night"]
["visgun","behavioral response to ethanol, learning or memory, long-term memory, olfactory learning"]
["Rhythmically expressed gene 2","circadian rhythm"]
["pigment dispersing factor","circadian rhythm and locomotor activity"]
["tyrosine aminotransferase","catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate, it is affected by the circadian rhythm and underexpressed in ebony mutants"]
["Cryptochrome 2"]
["ebony"]
["predicted transient receptor potential channel pyrexia","behaviour in response to circadian temerature changes"]
["fruitless"]
["major royal jelly protein","Member of the yellow family plays a role in the eusocial behavior in insects such as the honey bee"]
["major royal jelly protein 4 precursor, putative"]

{"sheet":"Gene expression","index":18,"n_rows":58,"n_cols":18,"rows_kept":58,"flags":["formulas_cached_only"]}
["nucleotide sinthesis",null,"trna synthesis",null,"transcription",null,"Cytoplasn-nucleus traffic",null,"RNA editting",null,"aminoacids synthesis and meta and catabolism",null,"translation",null,"protien editting",null,"Visicule trafic"]
["Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected","Gene","Reason why selected"]
["xanthine dehydrogenase","purine metabolism","tRNA-dihydrouridine synthase",null,"zinc finger protein on ecdysone puffs-like isoform X1",null,"nucleoprotein TPR","component of the nuclear pore and important for nucleus cytoplasm trafficking of proteins and mRNAs","ATP-dependent RNA helicase DDX17",null,"S-adenosylmethionine synthase","is the rate-limiting step of the methionine cycle and is also involved in gene transcription and production of secondary metabolites. It is a drug target, for conditions such as depression, dementia, vacuolar myelopathy, and migraine ","40S ribosomal protein S26",null,"sumo ligase","ubiquitination","phosphatidylinositol 4-kinase beta","involved in golgi to plasma membrane trafficking"]
["Amidophosphoribosyltransferase","the committing step in purine synthesis","glycyl-tRNA synthetase",null,"DNA-directed RNA polymerases",null,"exportin-5","transport between the nuclear and cytoplasmic compartments","ATP-dependent RNA helicase p62",null,"glutaryl-CoA dehydrogenase","plays a role in the metabolism of lysine, hydroxylysine and tryptophan. Excessive levels of their intermediate breakdown products (glutaric acid, glutaryl-CoA, 3-hydroxyglutaric acid, glutaconic acid) can accumulate and cause damage to the brain and other, particularly the basal ganglia, which are regions that help regulate movement ","eukaryotic translation initiation factor",null,"serpin 4","involved in the regulation of peptide maturation, especially neuropeptide processing","X box binding protein-1","Endoplasmic reticulum stress response"]
["phosphoribosylformylglycinamidine synthase","purine metabolism ","tyrosyl-tRNA synthetase",null,"putative histone H4",null,"nucleoporin Nup54",null,"Dicer 2","RNA editing","Homogentisate 1,2-dioxygenase","catalyzes the conversion of homogentisate to 4-maleylacetoacetate. Homogentisate 1,2-dioxygenase or HGD is involved in the catabolism of aromatic rings, more specifically in the breakdown of the amino acids tyrosine and phenylalanine. Homogentisate when oxidized by the body will produce the compound known as the ochronotic pigment, which causes a black color. it is also involved in the synthesis of hormones and neurotransmitters ","40S ribosomal protein",null,"Serine/threonine-protein kinase N2","post translational modification","calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X2"]
["carbamoyl-phosphate synthase","pyrimidine and argenine biosynthesis","valyl-tRNA synthetase",null,"chromatin regulatory protein sir2",null,"nuclear pore complex protein Nup160",null,"WW domain-binding protein 11","RNA processing and splicing","phosphoserine phosphatase","glycine, serine and threonine metabolism","eukaryotic translation initiation factor 4",null,"COP9 signalosome complex","protein ubiquitination ","syntaxin 18 (ER)"]
["5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase","purine biosynthesis","tRNA-dihydrouridine synthase 2",null,"PREDICTED: proline-, glutamic acid- and leucine-rich protein 1-like","PELP-1 (MNAR) is a transcriptional corepressor for nuclear receptors such as glucocorticoid receptors and a coactivator for estrogen receptors","importins","trafic cytoplasm nucleus","Exosomal 3'-5' exoribonuclease complex subunit Rrp45","rna processing","proton-coupled amino acid transporter 1 ",null,"40S ribosomal protein S14",null,"E3 ubiquitin-protein ligase AMFR-like",null,"golgins"]
["Bifunctional purine biosynthesis protein PURH",{"$nulls":3},"AF4/FMR2 family member 4-like","transcription elongation","Karyopherins","are a group of proteins involved in transporting molecules between the cytoplasm and the nucleus of a eukaryotic cell.","ribosomal RNA methyltransferase",null,"proton-coupled amino acid transporter 4",null,"60S acidic ribosomal protein P2",null,"Polyubiquitin","protein degradation","vacuolar fusion protein MON1 homolog A, "]
["adenine phosphoribosyltransferase","purine biosythesis",null,null,"Nuclear factor related to kappa-B-binding protein","transcription in response to stress, cytokins and free radicals, plays a rol in immune response to infection",null,null,"nuclear speckle splicing regulatory protein 1",{"$nulls":3},"60S ribosomal proteins",null,"SUMO-activating enzyme","blocks ubiquitin binding and prevents protein degradation ","vacuolar amino acid transporter"]
["CAD protein","involved in pyrimidine biosynthesis ",null,null,"JmjC domain-containing histone demethylation protein 1B","epigenetics",null,null,"Protein CASC3","core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD)",null,null,"ribosomal protein S15Ae",null,"E3 ubiquitin-protein ligase TRIP12",null,"Ras-related protein Rab","small GTP/GDP-binding proteins that play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane."]
[{"$nulls":4},"MLL1/MLL complex subunit KIAA1267","epigenetic modification of histone",null,null,"regulator of nonsense transcripts 1",{"$nulls":3},"28S ribosomal RNA",null,"cathepsin F","proteolysis","vacuolar protein sorting-associated protein 54","golgi "]
[{"$nulls":4},"histone deacetylase complex subunit SAP18",{"$nulls":3},"U1 small nuclear ribonucleoprotein","spliceosome",null,null,"40S ribosomal protein S10",null,"protein transport protein Sec23A",null,"seipin","part of the Endoplasmic Reticulum membrane "]
[{"$nulls":4},"MLX-interacting protein","interaction with carbohydrate response element sequences of DNA. binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes",null,null,"RNA-binding protein 39-like",{"$nulls":3},"40S ribosomal protein S29",null,"peptidyl-prolyl cis-trans isomerase",null,"vacuolar ATPase subunit H"]
[{"$nulls":4},"jmjC domain-containing histone demethylation protein 1-like",{"$nulls":3},"nucleostemin 1","has a critical rol in pre-rRNA processing",null,null,"40S ribosomal protein S15 ",null,"proteasomal ubiquitin receptor ADRM1",null,"V-ATPase","membranes and organelles"]
[{"$nulls":4},"Histone deacetylase 11",{"$nulls":3},"gar2 protein","assembly of pre-rRNA",null,null,"ribosomal protein L35",null,"ubiquitin-specific protease",null,"vacuolar protein sorting-associated protein 35"]
[{"$nulls":4},"La-related protein","stimulatory rol in transcription",null,null,"Pre-mRNA-splicing factor cwc22 ",{"$nulls":3},"translation elongation factor 2 ",null,"Cullin","play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms"]
[{"$nulls":4},"GA-Binding Protein","Essential Components of a Retinoic Acid-Induced Enhanceosome in Myeloid Cells",null,null,"Serine/arginine repetitive matrix protein","involved in pre-mRNA processing",null,null,"Nucleolin ","eukaryotic nucleolar phosphoprotein involved in the synthesis and maturation of ribosomes","ubiquitin-conjugating enzyme E2"]
[{"$nulls":4},"histone deacetylase 4","epigenetics",null,null,"splicing factor 3A ",{"$nulls":3},"elongation factor 1-alpha",null,"kelch-like protein diablo-like","protein ubiquitination"]
[{"$nulls":4},"THO complex","cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression",null,null,"integrator complex","mediator of small nucleolar RNA processing ",null,null,"elongation factor 1-beta",null,"cysteine proteinase"]
[{"$nulls":4},"RNA polymerase",{"$nulls":3},"pre-mRNA-processing factor 17",{"$nulls":3},"eukaryotic translation initiation factor",null,"Derlin-2","homeostasis of the endoplasmic reticulum (ER) must be refolding or degradation of unfolded or misfolded proteins"]
[{"$nulls":4},"histone h3 methyltransferase ",{"$nulls":3},"SURP and G-patch domain-containing protein 1","premRNA splicing",null,null,"translation initiation factor eIF-2B subunit delta-like isoform 1",null,"Ubiquitin-conjugating enzyme E2 J1"]
[{"$nulls":4},"Transcriptional regulatory protein PHO23",{"$nulls":3},"RNA-binding protein 28",{"$nulls":5},"caseinolytic peptidase"]
[{"$nulls":4},"ccaat/enhancer binding protein beta","regulation of gene transcription",null,null,"Cabeza","RNA binding abundant in adult heads ",{"$nulls":4},"CAAX prenyl protease"]
[{"$nulls":4},"TATA element modulatory factor",{"$nulls":3},"splicing factor 1",{"$nulls":5},"PREDICTED: kelch-like 24-like ","substrate adaptors for Cullin 3 ubiquitin ligases"]
[{"$nulls":4},"CCR4-NOT transcription complex subunit 6-like, vesicle transport V-snare protein vti1a, ",{"$nulls":3},"pre-mRNA-processing factor 40 homolog A"]
[{"$nulls":4},"DNA-directed RNA polymerase III",{"$nulls":3},"Protein muscleblind","alternative splicing involved in the development of the muscles, CNS and eyes"]
[{"$nulls":4},"TAF4b RNA polymerase II ",{"$nulls":3},"putative helicase mov-10-B.1","helicases are not only involved in DNA replication but also in several RNA editting processes "]
[{"$nulls":4},"transcription initiation factor TFIID subunit 12 ",{"$nulls":3},"chromodomain-helicase-DNA-binding protein 7 isoform X3"]
[{"$nulls":4},"TATA-binding protein-associated factor 172 ",{"$nulls":3},"WD repeat-containing protein 43","polyA RNA binding"]
[{"$nulls":4},"AP-1","gene activator",null,null,"integrator complex","involved in the the transcription and processing of small nuclear RNAs (snRNAs) which primary function is the processing of pre-mRNA (hnRNA) in the nucleus"]
[{"$nulls":4},"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin","chromatin alteration and gene regulation",null,null,"Splicing factor U2Af"]
[{"$nulls":4},"histone deacetylase Rpd3",{"$nulls":3},"ribosomal RNA processing protein 1"]
[{"$nulls":4},"high mobility group protein B2","facilitates chromatin bending and the interaction of cis-acting elements",null,null,"pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22"]
[{"$nulls":4},"CCR4-NOT transcription complex subunit 2","positive elongation factor for RNA polymerase II (RNAPII)",null,null,"ribosomal RNA small subunit methyltransferase NEP1","rRNA modification plays an essential role in rRNA processing and ribosome biogenesis"]
[{"$nulls":4},"cAMP-responsive element-binding protein","transcription factor",null,null,"CLP1","Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation "]
[{"$nulls":4},"transcription factor 001R ",{"$nulls":3},"poly A binding protein"]
[{"$nulls":4},"upstream-binding protein",{"$nulls":3},"RNA-binding protein 39-like"]
[{"$nulls":4},"Multiprotein bridging factor 1","bridges between tata box-binding protein and transcription factors",null,null,"Plasminogen activator inhibitor 1 RNA-binding protein"]
[{"$nulls":4},"histone H2A",{"$nulls":3},"polyadenylate-binding protein 1","RNA metabolism, splicing"]
[{"$nulls":4},"Histone deacetylase 11",{"$nulls":3},"cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1"]
[{"$nulls":4},"Activator of basal transcription",{"$nulls":3},"mRNA-decapping enzyme 2"]
[{"$nulls":4},"Juvenile hormone-inducible protein",{"$nulls":3},"pre-mRNA-splicing factor cwc25"]
[{"$nulls":4},"histone-lysine N-methyltransferase E","histone modifying enzyme, epigenetics",null,null,"endoribonuclease Dcr-1"]
[{"$nulls":4},"histone-binding protein Caf1","chromatin remodeling, epigenetics",null,null,"ATP-dependent RNA helicase belle"]
[{"$nulls":4},"Histone-lysine N-methyltransferase","methylome, epigenetics",null,null,"pre-mRNA-splicing factor Slu7"]
[{"$nulls":4},"general transcription factor IIE",{"$nulls":3},"polyA polymerase"]
[{"$nulls":4},"Upstream stimulatory factor ",{"$nulls":3},"similar to SON DNA-binding protein","splicing"]
[{"$nulls":4},"histone deacetylase 6",{"$nulls":3},"5'-3' exoribonuclease 1"]
[{"$nulls":4},"RNA polymerase II",{"$nulls":3},"luc7","splicing complex"]
[{"$nulls":4},"ribosome production factor 2 homolog",{"$nulls":3},"Exosome complex exonuclease RRP45"]
[{"$nulls":4},"RNA polymerase-associated protein Rtf1",{"$nulls":3},"small nuclear ribonucleoprotein Sm D3 ","splicing"]
[{"$nulls":4},"lysine-specific histone demethylase 1A","epigenetics",null,null,"small nuclear ribonucleoprotein Sm D2 "]
[{"$nulls":4},"chromodomain-helicase-DNA-binding protein Mi-2"]
[{"$nulls":4},"Transcriptional adapter 2B"]
[{"$nulls":4},"lysine-specific demethylase NO66","Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code"]
[{"$nulls":4},"histone diacetylase "]
[{"$nulls":4},"histone h4"]
[{"$nulls":4},"Histone-lysine N-methyltransferase SETMAR"]