Ontology-ID Ontology Name Ontology Type Number Changed Number Measured Number in Ontology Percent Changed Percent Present Z Score FisherExactP AdjustedP redundant with terms inverse redundant gene symbols AVG-kME STDEV-kME GO:0002376 immune system process biological_process 270 797 1258 33.8770388959 63.3545310016 32.6184457718 2.67818952904e-134 3.45754268199e-130 MHC protein complex|NADPH oxidase complex|T cell receptor complex|caspase regulator activity|cell surface binding|chemokine receptor binding|glycoprotein binding|leukocyte proliferation|lymph node development|peptidoglycan binding|positive regulation of response to external stimulus|regulation of phagocytosis|somatic cell DNA recombination|tumor necrosis factor receptor binding ADA|AIM2|APOL1|ARHGDIB|B2M|BCL11B|BST2|BTLA|C1R|C3AR1|C4A|C4B|C5AR1|CARD11|CARD9|CASP1|CCL22|CCR1|CCR2|CCR4|CCR5|CCR6|CCR7|CCR9|CD14|CD180|CD19|CD1A|CD1C|CD1D|CD2|CD209|CD244|CD247|CD27|CD274|CD28|CD3D|CD3E|CD3G|CD4|CD40LG|CD48|CD5|CD58|CD7|CD70|CD74|CD79A|CD79B|CD80|CD83|CD84|CD86|CD8A|CD8B|CD96|CFB|CFP|CIITA|CLEC4A|CLEC4C|CLEC4D|CLEC7A|CNR2|CORO1A|CR1|CR2|CRTAM|CSF1|CSF3R|CST7|CTLA4|CTSC|CTSS|CTSW|CXCL13|CXCL16|CXCR4|CXCR5|CYBA|CYBB|DOCK2|DOK2|EBI3|EOMES|FASLG|FCAR|FCER1G|FCGR1A|FCGR2B|FCGR3A|FCN1|FLT3|FOXP3|FTH1|FUT7|GAPT|GBP2|GPR183|GPR65|GRAP2|GZMA|GZMM|HAMP|HHEX|HLA-A|HLA-B|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DQB2|HLA-DRA|HLA-DRB1|HLA-DRB5|HLA-E|HLA-F|HMGB2|ICAM1|ICOS|IFI30|IFI35|IFI44L|IFITM1|IFITM2|IFITM3|IFNG|IGSF6|IKZF1|IL10|IL12A|IL12B|IL15|IL16|IL18|IL18BP|IL18R1|IL18RAP|IL1B|IL1RN|IL21R|IL23A|IL27RA|IL2RA|IL2RG|IL32|IL7R|INPP5D|IRF1|IRF4|IRF8|ITGAL|ITGAM|ITGAX|ITGB2|ITIH1|ITK|KLHL6|KLRK1|LAX1|LCK|LCP2|LEF1|LIF|LILRA5|LILRB1|LILRB2|LST1|LTA|LTB|LY75|LY86|LY9|LY96|LYL1|LYN|MAP3K8|MAPKAPK2|MICB|MNDA|MS4A1|NCF1|NCF2|NCF4|NCKAP1L|NCR1|NCR3|NFAM1|NFATC2|NLRC3|NLRC5|NLRP3|NOD1|NOD2|OAS1|OASL|PAX5|PDCD1|PDCD1LG2|PIK3CD|POU2AF1|POU2F2|PRF1|PRG4|PRKCQ|PSMB8|PSMB9|PTAFR|PTPN22|PTPRC|RELB|RGS1|RHOH|RSAD2|S100A9|S1PR4|SAMHD1|SELL|SELPLG|SEMA7A|SERPINB9|SH2D1A|SIRPA|SKAP1|SLA2|SLAMF1|SLAMF7|SLC16A3|SLC7A5|SLC7A7|SPI1|SPN|SYK|TAP1|TAP2|TCF7|TGFB1|THEMIS|TLR10|TLR2|TLR6|TLR7|TLR8|TNF|TNFAIP8L2|TNFRSF13B|TNFRSF13C|TNFRSF1B|TNFSF13B|TNFSF14|TNFSF8|TNFSF9|TRAT1|TREM2|TREML1|TREML2|TRIM22|UBD|UNC13D|VAV1|VNN1|WAS|XCL1|XCL2|ZAP70 0.729130380167 0.134648346165 GO:0050776 regulation of immune response biological_process 140 366 588 38.2513661202 62.2448979592 25.1485314572 7.0761400992e-74 1.30504240972e-70 MHC protein binding|T cell receptor complex|negative regulation of smooth muscle cell proliferation|regulation of cell killing|regulation of phagocytosis ADA|ARRB2|B2M|BTLA|C1R|C3AR1|C4A|C4B|CARD11|CARD9|CCR2|CD19|CD1D|CD200R1|CD226|CD247|CD28|CD37|CD3D|CD3E|CD3G|CD4|CD40LG|CD74|CD79A|CD79B|CD80|CD86|CD8A|CD8B|CD96|CFB|CFP|CLEC7A|CR1|CR2|CRTAM|CTLA4|EREG|FCER1G|FCER2|FCGR2B|FCGR3A|FOXP3|GRAP2|HCST|HLA-A|HLA-B|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|HLA-F|HMOX1|ICAM1|ICAM3|IFITM1|IFNG|IL10|IL12A|IL12B|IL12RB1|IL15|IL1B|IL23A|IL27RA|IL2RA|IL7R|INPP5D|IRF4|ITGAL|ITGB2|ITGB7|ITK|KLHL6|KLRD1|KLRG1|KLRK1|LAG3|LAX1|LCK|LCP2|LILRA1|LILRB1|LILRB2|LTA|LY96|LYN|MAPKAPK2|MICB|MNDA|NCKAP1L|NCR1|NCR3|NFAM1|NFATC2|NLRC5|NOD1|NOD2|POLR3C|PRKCQ|PTPN22|PTPRC|SAMHD1|SASH3|SELL|SEMA7A|SH2D1A|SKAP1|SLA2|SOCS1|SPN|SYK|TAP1|TAP2|TBX21|TGFB1|THEMIS|TLR10|TLR2|TLR6|TLR7|TLR8|TNF|TNFRSF13C|TNFSF13B|TRAFD1|TRAT1|TYROBP|UNC13D|WAS|XCL1|ZAP70 0.736746487221 0.132548352391 GO:0004872 receptor activity molecular_function 203 760 1824 26.7105263158 41.6666666667 23.4898298902 1.78776507434e-76 5.77001177743e-73 immunoglobulin binding APOBR|BTLA|BTN1A1|C3AR1|C5AR1|CCR1|CCR2|CCR3|CCR4|CCR5|CCR6|CCR7|CCR9|CCRL2|CD14|CD180|CD1D|CD2|CD200R1|CD209|CD226|CD244|CD247|CD27|CD274|CD28|CD300A|CD300C|CD300E|CD300LB|CD300LF|CD33|CD3D|CD3E|CD3G|CD4|CD5|CD6|CD69|CD7|CD72|CD74|CD79A|CD79B|CD80|CD84|CD86|CD8A|CD8B|CLEC12A|CLEC12B|CLEC17A|CLEC1B|CLEC2D|CLEC4A|CLEC7A|CNR2|CR1|CR2|CSF1R|CSF2RB|CSF3R|CXCL16|CXCR3|CXCR4|CXCR5|CXCR6|CYSLTR1|EBI3|ESR2|EVI2A|FCAR|FCER1G|FCER2|FCGR1A|FCGR2A|FCGR2B|FCGR3A|FCRL1|FCRL2|FCRL3|FCRL5|FLT3|FOLR2|FPR1|FPR2|FPR3|GP1BA|GPA33|GPR132|GPR141|GPR15|GPR171|GPR174|GPR18|GPR183|GPR31|GPR55|GPR65|GPR68|GPR82|GPR84|HLA-A|HLA-B|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-F|HTR7|ICAM1|IGSF6|IL10RA|IL12B|IL12RB1|IL15RA|IL18R1|IL18RAP|IL21R|IL27RA|IL2RA|IL2RB|IL2RG|IL3RA|IL7R|IL9R|ITGAL|ITGAM|ITGAX|ITGB2|ITGB7|KLRB1|KLRD1|KLRG1|KLRK1|LAG3|LAIR1|LAIR2|LEF1|LILRA1|LILRA2|LILRA4|LILRA5|LILRA6|LILRB1|LILRB2|LILRB3|LILRB4|LPAR5|LTK|LY75|LY96|MS4A14|MS4A6A|MS4A7|NCKAP1L|NCR1|NCR3|NFAM1|NR1H3|OSCAR|P2RY10|P2RY13|PDCD1LG2|PILRA|PLAUR|PLXNC1|PRG4|PTAFR|PTPRC|PTPRE|PTPRO|RELT|S1PR4|SEMA7A|SIGLEC7|SLAMF1|SLAMF6|SLAMF7|SLC20A1|SPN|SUCNR1|TLR10|TLR2|TLR6|TLR7|TLR8|TNFRSF12A|TNFRSF13B|TNFRSF13C|TNFRSF17|TNFRSF1B|TNFRSF8|TNFRSF9|TREM2|TREML1|TREML2|VDR|XCR1 0.725112524458 0.133087831078 GO:0002684 positive regulation of immune system process biological_process 131 375 567 34.9333333333 66.1375661376 22.8085507345 2.45238579466e-63 3.51781117878e-60 negative regulation of smooth muscle cell proliferation|regulation of leukocyte migration|regulation of phagocytosis ADA|B2M|BTLA|C1R|C3AR1|C4A|C4B|C5AR1|CARD11|CARD9|CCR2|CD19|CD1D|CD2|CD226|CD247|CD27|CD274|CD28|CD37|CD3D|CD3E|CD3G|CD4|CD40LG|CD5|CD74|CD79A|CD79B|CD80|CD83|CD86|CFB|CFP|CLEC7A|CORO1A|CR1|CR2|CRTAM|CTLA4|EBI3|EREG|FCER1G|FCER2|FOXP3|GRAP2|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|HMOX1|ICAM1|ICOS|IFNG|IKZF1|IL12A|IL12B|IL12RB1|IL15|IL15RA|IL18|IL1B|IL23A|IL27RA|IL2RA|IL2RG|IL7R|INPP5D|ITGAL|ITK|KLHL6|KLRK1|LAG3|LAX1|LCK|LCP2|LTA|LY96|LYN|MAP3K8|MAPKAPK2|MICB|MNDA|NCKAP1L|NCR3|NFAM1|NFATC2|NOD1|NOD2|NR1H3|PDCD1|PDCD1LG2|POLR3C|PRKCQ|PTPN22|PTPRC|SASH3|SEMA7A|SH2D1A|SKAP1|SLA2|SPN|SYK|TAP1|TAP2|TBX21|TGFB1|THEMIS|TLR10|TLR2|TLR6|TLR7|TLR8|TNF|TNFRSF13C|TNFSF13B|TNFSF14|TRAT1|UNC13D|VAV1|VNN1|WAS|XCL1|ZAP70 0.739487585611 0.132208962971 GO:0002694 regulation of leukocyte activation biological_process 95 225 335 42.2222222222 67.1641791045 22.0465067418 2.75910964789e-54 2.74000811956e-51 negative regulation of smooth muscle cell proliferation ADA|BTLA|CARD11|CCR2|CD2|CD226|CD247|CD27|CD274|CD28|CD3D|CD3E|CD3G|CD4|CD40LG|CD5|CD74|CD80|CD83|CD86|CNR2|CORO1A|CTLA4|EBI3|FCER1G|FLT3|FOXP3|GRAP2|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|HMOX1|ICOS|IFNG|IKZF1|IL10|IL12A|IL12B|IL12RB1|IL15|IL15RA|IL18|IL1B|IL23A|IL27RA|IL2RA|IL2RG|IL7R|INPP5D|IRF4|ITGAL|KLRK1|LAG3|LAX1|LCK|LST1|LYN|MAP3K8|MNDA|NCKAP1L|NFAM1|NFATC2|NOD2|PDCD1|PDCD1LG2|PRKCQ|PTPN22|PTPRC|PTPRE|SASH3|SIT1|SLA2|SLAMF7|SPN|SYK|TBX21|TGFB1|TIGIT|TNFRSF13B|TNFRSF13C|TNFSF13B|TNFSF14|UNC13D|VAV1|VNN1|XCL1|ZAP70 0.766071599684 0.118879185779 GO:0006952 defense response biological_process 143 465 808 30.752688172 57.5495049505 21.7550871487 3.85345940263e-61 4.9748160888e-58 peptidoglycan binding AIF1|AOAH|APOL1|APOL2|APOL3|BST2|C1R|C3AR1|C4A|C4B|C5AR1|CARD9|CCL22|CCR1|CCR2|CCR3|CCR4|CCR5|CCR6|CCR7|CCR9|CD14|CD180|CD19|CD209|CD300C|CD40LG|CD48|CD74|CD83|CD84|CEBPE|CFB|CFP|CLEC1B|CLEC4A|CLEC4C|CLEC4D|CLEC7A|CORO1A|CR1|CR2|CSF3R|CXCL13|CXCR4|CYBA|CYBB|CYSLTR1|ESR2|FCER1G|FCGR1A|FGR|FPR2|GNLY|GPR68|GZMM|HAMP|HCK|HLA-B|IFITM1|IFITM2|IFITM3|IFNG|IL10|IL12A|IL12B|IL15|IL18R1|IL18RAP|IL1B|IL1RN|IL23A|IL27RA|IL2RA|IL32|IRF8|ITGAL|ITGB2|ITK|KLRG1|KLRK1|LILRA1|LILRA2|LILRA5|LILRA6|LILRB1|LILRB2|LILRB3|LSP1|LTA|LY75|LY86|LY96|LYZ|MAPKAPK2|MEFV|MMP25|MNDA|MX1|MX2|NCF1|NCF2|NCR1|NCR3|NFAM1|NLRC4|NLRC5|NLRP3|NMI|NOD1|NOD2|PLA2G2D|PRF1|PTAFR|PTPRC|RNASE6|RSAD2|S100A8|S100A9|SAMHD1|SERPINA1|SH2D1A|SLAMF7|SP140|SPN|TAP1|TGFB1|TLR10|TLR2|TLR6|TLR7|TLR8|TNF|TNFAIP8L2|TNFRSF1B|TNIP1|TRAT1|TREML1|TYROBP|UNC13D|VNN1|WAS|XCR1 0.70787360935 0.136473508201 GO:0009897 external side of plasma membrane cellular_component 55 108 159 50.9259259259 67.9245283019 18.8968298796 5.1795566681e-37 1.91051647386e-34 ADA|B2M|BTLA|CCR4|CCR5|CCR7|CD19|CD2|CD22|CD244|CD274|CD28|CD3E|CD4|CD5|CD69|CD74|CD79A|CD79B|CD80|CD83|CD86|CD8A|CLEC7A|CR2|CTLA4|CXCR3|CXCR4|FASLG|FCER1G|FCER2|ICAM1|ICOS|IL12RB1|IL2RA|IL2RB|IL2RG|IL7R|ITGAL|ITGAM|ITGAX|KLRD1|KLRK1|LAG3|MS4A1|PDCD1|PTPRC|SEMA7A|SLAMF1|SPN|TLR2|TNF|TNFRSF13B|TNFRSF13C|TNFRSF9 0.761214482327 0.109840596782 GO:0005886 plasma membrane cellular_component 300 1927 3659 15.5682407888 52.6646624761 17.7839910016 1.56785909746e-56 1.84009644984e-53 T cell receptor complex|cell surface binding|glycoprotein binding|growth factor binding|immunoglobulin binding|integrin complex ACY3|ADA|ADAM28|ADAP2|AIF1|APBB1IP|APOBR|APOE|ARRB2|ATP1A3|B2M|BTK|BTLA|C3AR1|C5AR1|CARD11|CASP10|CCR1|CCR2|CCR3|CCR4|CCR5|CCR6|CCR7|CCR9|CCRL2|CD101|CD14|CD180|CD19|CD1A|CD1C|CD1D|CD2|CD200R1|CD209|CD22|CD226|CD244|CD247|CD274|CD28|CD300A|CD300C|CD300E|CD300LB|CD300LF|CD33|CD3D|CD3E|CD3G|CD4|CD40LG|CD48|CD5|CD52|CD53|CD58|CD68|CD7|CD70|CD72|CD74|CD79A|CD79B|CD80|CD83|CD84|CD86|CD8A|CD8B|CD96|CFB|CLEC12A|CLEC12B|CLEC2D|CLECL1|CLSTN3|CNR2|CORO1A|CR2|CRTAM|CSF1|CSF1R|CSF2RB|CSF3R|CTLA4|CXCL16|CXCR3|CXCR4|CXCR5|CXCR6|CYSLTR1|CYTH4|DAPP1|DOK3|DPEP2|EBI3|EHD1|EREG|FASLG|FCAR|FCER1G|FCER2|FCGR1A|FCGR2A|FCGR2B|FCGR3A|FCRL1|FCRL2|FCRL3|FCRL5|FGD2|FLT3LG|FOLR2|FPR1|FPR2|FPR3|GAPT|GBP1|GBP2|GBP5|GNG8|GNGT2|GP1BA|GPA33|GPR132|GPR141|GPR15|GPR171|GPR174|GPR18|GPR183|GPR31|GPR55|GPR65|GPR68|GPR82|GPR84|HCLS1|HCST|HLA-A|HLA-B|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|HLA-F|HTR7|ICAM1|ICAM3|ICOS|IFI30|IFITM1|IFITM2|IFITM3|IL10RA|IL16|IL18R1|IL1RN|IL2RA|IL2RB|IL2RG|IL3RA|IL7R|IL9R|INPP5D|IPCEF1|ITGAL|ITGAM|ITGAX|ITGB2|ITGB7|ITK|KCNE1|KLRB1|KLRD1|KLRK1|LAIR1|LAX1|LCK|LILRA1|LILRB1|LILRB2|LILRB4|LPAR5|LSP1|LTK|LY86|LY96|LYN|MICB|MMP25|MREG|MS4A1|NCKAP1L|NCR1|NCR3|NFAM1|NFATC2|NKG7|NOD1|NOD2|OSCAR|OTOA|P2RY10|P2RY13|PARP14|PARVG|PDCD1|PDCD1LG2|PIK3CD|PILRA|PLAU|PLAUR|PLCB2|PLSCR1|PLXNC1|PPP1R16B|PRF1|PRKCQ|PTAFR|PTPRC|PTPRE|RAB15|RAB33A|RAC2|RASGRP1|RELT|RGS1|RGS14|RGS18|RGS19|RHOH|S100A8|S100A9|S1PR4|SELL|SELPLG|SEMA7A|SIGLEC10|SIRPA|SIRPB1|SIT1|SKAP1|SLA2|SLAMF1|SLAMF6|SLAMF7|SLC12A3|SLC14A2|SLC16A3|SLC20A1|SLC2A6|SLC43A2|SLC5A5|SLC7A5|SLC7A7|SNX20|SPHK1|SPN|SUCNR1|SYK|TAGLN2|TAP1|TAP2|TIGIT|TLR10|TLR2|TLR6|TLR7|TNF|TNFRSF12A|TNFRSF17|TNFRSF1B|TNFRSF8|TNFSF13B|TNFSF14|TNFSF9|TRAT1|TREM2|TREML1|TREML2|TRIM16|TRPV2|TYROBP|VAV1|VNN1|VNN2|VNN3|XCR1|XKRX|ZAP70 0.715377091697 0.148601595057 GO:0002697 regulation of immune effector process biological_process 57 136 198 41.9117647059 68.6868686869 16.9273880357 1.59435146719e-32 4.67797214578e-30 negative regulation of smooth muscle cell proliferation|regulation of cell killing|regulation of response to biotic stimulus ARRB2|B2M|CCR2|CD226|CD247|CD28|CD37|CD4|CD40LG|CD74|CD80|CD86|CD8B|CRTAM|DOCK2|FCER1G|FCER2|FOXP3|HCK|HLA-A|HMOX1|ICAM1|IFIT1|IFNG|IL10|IL12A|IL12B|IL12RB1|IL15|IL1B|IL23A|IL27RA|IL2RA|IL7R|IRF4|KLRK1|LAG3|LCK|LTA|MICB|NCR1|NCR3|NOD2|PTPRC|SASH3|SEMA7A|SH2D1A|SPN|SYK|TAP1|TAP2|TBX21|TGFB1|TLR2|TNF|UNC13D|XCL1 0.72050517614 0.134436823047 GO:0005887 integral to plasma membrane cellular_component 132 567 1092 23.2804232804 51.9230769231 16.7103167071 4.30755532372e-41 1.98609068676e-38 cell surface binding BST2|BTLA|BTN1A1|C3AR1|C5AR1|CCR1|CCR2|CCR3|CCR4|CCR5|CCR6|CCR7|CCR9|CCRL2|CD19|CD1A|CD1C|CD1D|CD2|CD22|CD226|CD27|CD28|CD300C|CD33|CD3E|CD3G|CD40LG|CD48|CD5|CD52|CD58|CD6|CD69|CD70|CD72|CD79B|CD83|CD84|CD8A|CD8B|CD96|CEACAM4|CLEC1B|CLEC2B|CLEC2D|CLEC4A|CNR2|CR1|CSF1R|CSF2RB|CSF3R|CTLA4|CXCR3|CXCR5|CXCR6|CYBB|CYSLTR1|EREG|EVI2B|FASLG|FCAR|FCER1G|FCER2|FLT3|GP1BA|GPA33|GPR15|GPR183|GPR31|GPR55|GPR65|GPR68|HLA-A|HLA-B|HLA-DPA1|HLA-DQA1|HLA-DQA2|HLA-DRA|HLA-DRB1|HTR7|ICAM1|ICAM3|ICOS|IGSF6|IL15|IL27RA|IL2RB|IL2RG|IL9R|KLRK1|LAPTM5|LILRA6|LILRB1|LILRB2|LILRB3|LRMP|LTK|LY75|MICB|MS4A1|NCKAP1L|NCR1|NCR3|NINJ2|NKG7|PTAFR|PTPRC|PTPRO|S1PR4|SELL|SELPLG|SIGLEC7|SIGLEC9|SIRPB1|SIT1|SLC12A3|SLC16A3|SLC20A1|SLC7A7|SPN|SYNGR3|TLR2|TLR6|TNF|TNFRSF13B|TNFRSF9|TNFSF8|TRAT1|TRPV2|TYROBP|XCR1 0.731171155114 0.138480143951 GO:0071345 cellular response to cytokine stimulus biological_process 62 165 314 37.5757575758 52.5477707006 16.3851965693 5.03847138078e-32 1.44548145613e-29 B2M|CCR1|CCR2|CD74|CIITA|CSF2RB|CYBA|EBI3|EREG|FCGR1A|GBP1|GBP2|HLA-A|HLA-B|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|HLA-F|ICAM1|IFI30|IFI35|IFIT1|IFIT2|IFIT3|IFITM1|IFITM2|IFITM3|IFNG|IL12RB1|IL15RA|IL1B|IL21R|IL2RB|IRF1|IRF4|IRF5|IRF8|JAK3|LEF1|MX1|MX2|OAS1|OASL|PTAFR|SELPLG|SOCS1|SP100|STAT4|TCF7|TNF|TNFRSF17|TNFRSF1B|TNFRSF8|XAF1 0.712314978952 0.143547544668 GO:0032944 regulation of mononuclear cell proliferation biological_process 44 97 125 45.3608247423 77.6 15.6604185785 4.24305174144e-27 9.28437253932e-25 ADA|BTLA|CARD11|CCR2|CD274|CD28|CD3E|CD40LG|CD74|CD80|CORO1A|CSF1|CTLA4|EBI3|FOXP3|IFNG|IL10|IL12A|IL12B|IL12RB1|IL15|IL18|IL1B|IL23A|IL2RA|INPP5D|ITGAL|LST1|MNDA|NCKAP1L|NFATC2|PDCD1LG2|PRKCQ|PTPN22|PTPRC|SASH3|SPN|SYK|TGFB1|TNFRSF13B|TNFRSF13C|TNFSF13B|XCL1|ZAP70 0.764074560205 0.121034574424 GO:0001817 regulation of cytokine production biological_process 69 225 303 30.6666666667 74.2574257426 14.9243076366 3.15476146605e-29 7.68452274089e-27 negative regulation of smooth muscle cell proliferation|peptidoglycan binding|regulation of phagocytosis ARRB2|C3AR1|C5AR1|CARD11|CARD9|CASP1|CCR2|CD14|CD28|CD3E|CD4|CD40LG|CD74|CD80|CD83|CD86|CLEC7A|CRTAM|EBI3|EREG|FCER1G|FOXP3|HMOX1|IFNG|IGF2BP2|IGF2BP3|IL10|IL12A|IL12B|IL12RB1|IL15|IL18|IL1B|IL23A|IL27RA|INPP5D|IRF1|IRF4|IRF8|KLRK1|LAG3|LEF1|LTA|LTB|NCKAP1L|NFAM1|NLRC5|NLRP3|NOD1|NOD2|POLR3C|PRKCQ|SASH3|SEMA7A|SPN|SRGN|SYK|TGFB1|TIGIT|TLR2|TLR6|TLR7|TLR8|TNF|TNFRSF13C|TNFRSF8|TRIM16|UBE2L6|XCL1 0.711762289739 0.144681505064 GO:0034341 response to interferon-gamma biological_process 36 74 171 48.6486486486 43.2748538012 14.8198082803 1.0487775472e-23 1.93424544776e-21 B2M|CD86|CIITA|CXCL16|FCGR1A|GBP1|GBP2|HLA-A|HLA-B|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|HLA-F|ICAM1|IFI30|IFNG|IL12RB1|IRF1|IRF4|IRF5|IRF8|KYNU|OAS1|OASL|PTAFR|SOCS1|SP100|UBD 0.717743438 0.144135858886 GO:0019955 cytokine binding molecular_function 38 85 115 44.7058823529 73.9130434783 14.4057056999 2.80413826158e-23 4.95909930918e-21 growth factor binding CCR1|CCR2|CCR3|CCR4|CCR5|CCR6|CCR7|CCR9|CCRL2|CD74|CSF1R|CSF2RB|CSF3R|CXCR3|CXCR4|CXCR5|CXCR6|EBI3|IL10RA|IL12A|IL12B|IL12RB1|IL15RA|IL18BP|IL18R1|IL21R|IL27RA|IL2RA|IL2RB|IL2RG|IL3RA|IL7R|IL9R|TNFRSF17|TNFRSF1B|TNFRSF8|TRIM16|XCR1 0.747407335737 0.1365255374 GO:0031341 regulation of cell killing biological_process 21 30 55 70.0 54.5454545455 14.1843566086 6.39942611532e-19 8.60589491133e-17 regulation of immune effector process|regulation of immune response ARRB2|B2M|CD226|CRTAM|FCER2|ICAM1|IFNG|IL12A|IL12B|IL12RB1|IL23A|IL7R|KLRK1|LAG3|NCR1|NCR3|PTPRC|SH2D1A|TAP1|TAP2|XCL1 0.649414240095 0.136630382135 GO:0042611 MHC protein complex cellular_component 21 31 170 67.7419354839 18.2352941176 13.9070575258 1.86481378519e-18 2.31444116986e-16 immune system process B2M|CD1A|CD74|HLA-A|HLA-B|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DQB2|HLA-DRA|HLA-DRB1|HLA-DRB5|HLA-E|HLA-F|MICB|TAP2 0.73466037219 0.132560023128 GO:0051707 response to other organism biological_process 59 193 322 30.5699481865 59.9378881988 13.7483802933 4.94086193045e-25 9.52037724211e-23 BST2|C5AR1|CARD9|CCL22|CD1D|CD86|CEBPE|CFP|CLEC7A|CXCR4|FCER1G|FGR|GNLY|HAMP|HCK|IFI16|IFI35|IFI44|IFIT1|IFIT2|IFITM1|IFITM2|IFITM3|IFNG|IL10|IL12A|IL12B|IL23A|IL27RA|IRF8|KLRK1|LILRB1|LTA|LYZ|MX1|MX2|NLRC4|NLRC5|NLRP3|NOD1|NOD2|NPC2|PIM2|PLSCR1|POLR3C|PRF1|PTPRC|RSAD2|SAMHD1|SPN|TGFB1|TLR2|TLR6|TLR7|TLR8|TNF|TRIM22|UNC13D|XCL1 0.695977086881 0.126717693546 GO:0002683 negative regulation of immune system process biological_process 35 92 138 38.0434782609 66.6666666667 12.3805678955 9.11790162972e-19 1.20114398e-16 ADA|ARRB2|BTLA|CCR2|CD274|CD74|CNR2|CTLA4|FLT3|FOXP3|HMOX1|IFIT1|IL10|IL12B|IL27RA|IL2RA|IL7R|INPP5D|LAG3|LAX1|LST1|MICB|MNDA|NOD2|PDCD1LG2|PTPN22|PTPRC|SLA2|SPN|TAP1|TGFB1|TIGIT|TNFRSF13B|TRAFD1|XCL1 0.7291270728 0.113745075834 GO:0031347 regulation of defense response biological_process 64 256 354 25.0 72.3163841808 12.2099566412 8.7409640826e-22 1.39315859637e-19 ADA|AOAH|APOE|ARRB2|B2M|CARD9|CCR2|CD1D|CD226|CD247|CD28|CD4|CD86|CD8B|CLEC7A|CNR2|CRTAM|DOCK2|EREG|FCER1G|FOXP3|HCK|HLA-A|IFIT1|IFNG|IL10|IL12A|IL12B|IL12RB1|IL15|IL18|IL1B|IL23A|IL2RA|KLRK1|LAG3|LCK|LTA|LY96|MAPKAPK2|MICB|NCR1|NCR3|NLRC5|NOD1|NOD2|POLR3C|PTPN22|SAMHD1|SEMA7A|SH2D1A|SOCS1|SPN|TAP1|TGFB1|TLR10|TLR2|TLR6|TLR7|TLR8|TNF|TNFRSF1B|TRAFD1|XCL1 0.699338196328 0.147336836014 GO:0002521 leukocyte differentiation biological_process 40 118 149 33.8983050847 79.1946308725 12.1948762976 3.80163177102e-19 5.22117725148e-17 ADA|BCL11B|CD28|CD4|CD40LG|CD79A|CD8A|CEBPE|CSF1|EOMES|FLT3|FOXP3|FUT7|GAB3|GPR183|HHEX|IFI16|IKZF1|IL10|IL12B|IL7R|IRF1|IRF4|ITK|LCK|LEF1|LYL1|NFAM1|POU2F2|PTPN22|PTPRC|RELB|RHOH|SPI1|SPIB|TCF7|TGFB1|TNF|UBD|ZAP70 0.711025182375 0.123478639547 GO:0042101 T cell receptor complex cellular_component 11 12 12 91.6666666667 100.0 12.020572364 8.52895217906e-13 6.63305859227e-11 immune system process|plasma membrane|regulation of immune response CARD11|CD247|CD3D|CD3E|CD3G|CD4|CD8A|CD8B|SYK|TRAT1|ZAP70 0.814957803818 0.118361670521 GO:0005125 cytokine activity molecular_function 33 97 229 34.0206185567 42.3580786026 11.0960477292 4.51949420509e-16 4.86222251564e-14 tumor necrosis factor receptor binding CCL22|CD40LG|CD70|CMTM3|CMTM7|CSF1|CXCL13|CXCL16|EBI3|FASLG|FLT3LG|IFNG|IL10|IL12A|IL12B|IL15|IL16|IL18|IL1B|IL1RN|IL23A|IL24|IL32|LIF|LTA|LTB|TNF|TNFSF13B|TNFSF14|TNFSF8|TNFSF9|XCL1|XCL2 0.670668400848 0.131124394632 GO:0043900 regulation of multi-organism process biological_process 26 74 101 35.1351351351 73.2673267327 10.0737042053 2.54869302044e-13 2.09577241362e-11 ADA|B2M|CD247|CD28|CD4|CD8B|DOCK2|FCER2|HCK|HLA-A|IFIT1|IFNG|IL10|IL12B|IL12RB1|IL15|IL23A|IL2RA|IRF8|LCK|LTA|MICB|NOD2|SPN|TLR2|TNF 0.715086825654 0.141060568976 GO:0048535 lymph node development biological_process 8 9 20 88.8888888889 45.0 10.0695110729 2.46504197915e-09 1.34846152334e-07 immune system process CXCL13|CXCR5|IKZF1|IL15|IL7R|LTA|LTB|TGFB1 0.679956662375 0.127779362015 GO:0060326 cell chemotaxis biological_process 19 44 64 43.1818181818 68.75 9.93448467453 5.92908041202e-12 4.32454396154e-10 ARRB2|C5AR1|CCR2|CORO1A|CSF3R|CXCL16|FCER1G|HMGB2|IFNG|IL10|IL16|IL1B|ITGAM|ITGB2|LEF1|NCKAP1L|S100A9|SYK|XCL1 0.696675943632 0.172667793116 GO:0005576 extracellular region cellular_component 121 836 2036 14.4736842105 41.0609037328 9.78813787679 5.70094554707e-18 6.81474139006e-16 regulation of membrane protein ectodomain proteolysis ADAM28|ADAMDEC1|AOAH|APOE|APOL1|APOL2|APOL3|B2M|BTN1A1|C1R|C4A|C4B|CASP1|CCL22|CCR6|CD14|CD2|CD200R1|CD209|CD27|CD40LG|CD8A|CD8B|CFB|CFP|CHI3L2|CP|CSF1|CSF3R|CST6|CST7|CTHRC1|CTSS|CXCL13|CXCL16|EBI3|EREG|FAM20A|FASLG|FCAR|FCER2|FCGR3A|FCN1|FCRLA|FGL2|FLT3LG|FOLR2|GLIPR1|GNG8|GNGT2|GNLY|GZMA|GZMK|GZMM|HAMP|HAPLN3|HPSE|ICOS|IFI30|IFNG|IL10|IL12A|IL12B|IL15|IL15RA|IL16|IL18|IL18BP|IL1B|IL1RN|IL23A|IL24|IL32|IL7R|IL9R|INSL3|ITIH1|LAIR2|LGALS9|LIF|LILRA5|LTA|LY86|LY96|LYZ|METRNL|MMP25|NPC2|OSCAR|OTOA|PDCD1LG2|PILRA|PLA2G2D|PLAU|PLAUR|PLEK|PMCH|PNOC|PODNL1|PRF1|PRG4|RNASE2|RNASE6|S100A8|S100A9|SERPINA1|SIGLEC10|SPOCK2|SRGN|TGFB1|TIMP1|TMSB4X|TNF|TNFRSF1B|TNFSF13B|TNFSF14|TNR|TREM2|VMO1|XCL1|XCL2 0.66359454838 0.148740936277 GO:0009595 detection of biotic stimulus biological_process 10 15 20 66.6666666667 75.0 9.49777279798 2.6391458305e-09 1.41374990339e-07 CD1D|CLEC7A|CRTAM|LY96|NLRC4|NLRP3|NOD1|NOD2|TLR2|TLR6 0.7647063426 0.0835111244514 GO:0002831 regulation of response to biotic stimulus biological_process 22 62 74 35.4838709677 83.7837837838 9.32821054812 1.4169836682e-11 9.73045699812e-10 regulation of immune effector process B2M|CD226|CD247|CD28|CD4|CD40LG|CD8B|CRTAM|DOCK2|HCK|HLA-A|IFIT1|IL12A|IL12B|IL12RB1|IL15|IL23A|IL2RA|LCK|MICB|NOD2|SPN 0.736063566727 0.150570825686 GO:0005615 extracellular space cellular_component 67 368 821 18.2065217391 44.8233861145 9.32202250595 4.69725782213e-15 4.55951868298e-13 negative regulation of smooth muscle cell proliferation|tumor necrosis factor receptor binding ADA|APOE|APOL1|B2M|C4A|C4B|CCL22|CD14|CD40LG|CD70|CFP|CHI3L2|CMTM3|CMTM7|CP|CSF1|CTSZ|CXCL13|CXCL16|EBI3|EREG|FASLG|FCN1|FLT3LG|GNLY|HMGB2|HMOX1|ICAM1|IFNG|IL10|IL12A|IL12B|IL15|IL15RA|IL16|IL18|IL1B|IL1RN|IL24|IL32|IL9R|INSL3|LIF|LTA|LTB|LY86|LY96|LYZ|MFNG|PLAU|PMCH|S100A8|S100A9|SERPINA1|SERPINB9|SPN|SRGN|TGFB1|TNF|TNFAIP2|TNFSF13B|TNFSF14|TNFSF8|TNFSF9|VNN3|XCL1|XCL2 0.653916293701 0.138156624978 GO:0005164 tumor necrosis factor receptor binding molecular_function 10 16 42 62.5 38.0952380952 9.1308654108 6.6308221587e-09 3.33089159801e-07 cytokine activity|extracellular space|immune system process CD40LG|CD70|FASLG|LTA|LTB|TNF|TNFSF13B|TNFSF14|TNFSF8|TNFSF9 0.6980452468 0.139891416375 GO:0042287 MHC protein binding molecular_function 9 14 42 64.2857142857 33.3333333333 8.81253069662 2.76452693468e-08 1.30732757241e-06 regulation of immune response CD4|CD74|CD8A|CD8B|CLEC7A|KLRK1|LAG3|TAP1|TAP2 0.703931820556 0.161032698366 GO:0042346 positive regulation of NF-kappaB import into nucleus biological_process 10 17 26 58.8235294118 65.3846153846 8.79487184569 1.51728021061e-08 7.44794202242e-07 CD27|IL12B|IL1B|IL23A|PRKCQ|SPHK1|TLR2|TLR7|TNF|TNFSF14 0.6644812995 0.148542525867 GO:0005529 sugar binding molecular_function 31 119 208 26.0504201681 57.2115384615 8.74505871858 1.10598783465e-11 7.67650695986e-10 CD209|CD22|CD33|CD69|CD72|CLEC12A|CLEC12B|CLEC17A|CLEC1B|CLEC2B|CLEC2D|CLEC4A|CLEC4C|CLEC4D|CLEC4G|CLEC7A|CLECL1|FCER2|FCN1|GALNT6|KLRB1|KLRD1|KLRG1|KLRK1|LGALS9|LY75|SELL|SIGLEC10|SIGLEC14|SIGLEC7|SIGLEC9 0.694187407613 0.133092026981 GO:0070661 leukocyte proliferation biological_process 16 42 49 38.0952380952 85.7142857143 8.36119805864 2.63898106766e-09 1.41374990339e-07 immune system process CD40LG|CD79A|CD86|CRTAM|CXCR4|DOCK2|IL10|IL15|IL23A|IL7R|ITGAL|ITGAM|LEF1|PTPRC|TGFB1|TNFSF14 0.7668191505 0.145287160112 GO:0001772 immunological synapse cellular_component 9 16 16 56.25 100.0 8.11266067002 1.40399124936e-07 6.00183014213e-06 CD3E|CORO1A|GZMA|GZMB|ICAM1|ITGAL|PRKCQ|RHOH|ZAP70 0.765749682556 0.147686315247 GO:0050848 regulation of calcium-mediated signaling biological_process 10 20 25 50.0 80.0 7.93317259116 1.2058878334e-07 5.20669295291e-06 ADA|CD3E|CD4|CD8A|ITGAL|PLEK|SLA2|SYK|TRAT1|ZAP70 0.8128650363 0.0947781731 GO:0002237 response to molecule of bacterial origin biological_process 29 122 174 23.7704918033 70.1149425287 7.82549843965 5.53889471598e-10 3.3571422903e-08 B2M|C5AR1|CARD9|CASP1|CD14|CD86|CMPK2|CNR2|FASLG|HMGB2|ICAM1|IL10|IL12A|IL1B|IRF8|KLRK1|LTA|LY96|NCF2|NOD2|NR1H3|PTAFR|S100A8|S100A9|SERPINA1|SOCS1|SOD2|TLR2|TLR6 0.652504451379 0.142914909511 GO:0042834 peptidoglycan binding molecular_function 5 6 9 83.3333333333 66.6666666667 7.66668030223 6.2752546775e-06 0.00020509756427 defense response|immune system process|regulation of cytokine production CD14|NLRP3|NOD1|NOD2|TLR2 0.7404173922 0.0893214858565 GO:0007159 leukocyte cell-cell adhesion biological_process 11 25 38 44.0 65.7894736842 7.64910928793 1.45287109233e-07 6.14969370557e-06 CD209|CD40LG|FERMT3|ICAM1|ITGAL|ITGAM|ITGB2|PTPRC|SELPLG|SYK|TNF 0.782042632727 0.141471154175 GO:0007204 elevation of cytosolic calcium ion concentration biological_process 21 77 117 27.2727272727 65.811965812 7.46002737915 9.81003849275e-09 4.87106142082e-07 C3AR1|C5AR1|CCR1|CCR2|CCR3|CCR4|CCR5|CCR6|CCR7|CCR9|CD52|CXCL13|CXCR3|CXCR4|CYSLTR1|IL1B|LCK|PMCH|PTPRC|S1PR4|XCR1 0.718073084429 0.132934676985 GO:0019865 immunoglobulin binding molecular_function 7 12 17 58.3333333333 70.5882352941 7.31847413171 2.69662350412e-06 9.35844339736e-05 plasma membrane|receptor activity FCAR|FCER1G|FCER2|FCGR1A|FCGR2A|FCGR2B|FCGR3A 0.684321485143 0.128307308152 GO:0019835 cytolysis biological_process 8 16 25 50.0 64.0 7.09445592924 2.34369719063e-06 8.19976442575e-05 APOL1|GZMA|GZMB|GZMH|GZMM|LYZ|MICB|PRF1 0.756077126125 0.0552398247525 GO:0032103 positive regulation of response to external stimulus biological_process 19 70 120 27.1428571429 58.3333333333 7.06640643636 5.39781663164e-08 2.45372579981e-06 immune system process C3AR1|C5AR1|CCR2|CD28|CD74|FCER1G|IL12B|IL15|IL16|IL18|IL1B|IL23A|LTA|NCKAP1L|TGFB1|TLR2|TLR7|TNF|XCL1 0.731668957053 0.125209508888 GO:0002763 positive regulation of myeloid leukocyte differentiation biological_process 9 20 34 45.0 58.8235294118 7.02230990939 1.62888903957e-06 5.8740104751e-05 CSF1|IFNG|IKZF1|IL12B|IL23A|LEF1|LIF|RUNX1|TNF 0.566945894556 0.111422822649 GO:0002685 regulation of leukocyte migration biological_process 12 33 52 36.3636363636 63.4615384615 7.0031863505 4.80680406024e-07 1.88048001266e-05 positive regulation of immune system process ADA|C3AR1|C5AR1|CCR2|CD74|HMOX1|ICAM1|IL23A|NCKAP1L|NOD2|TLR2|XCL1 0.718699181917 0.137695372312 GO:0060558 regulation of calcidiol 1-monooxygenase activity biological_process 5 7 13 71.4285714286 53.8461538462 6.99897397446 2.07913934713e-05 0.000605907200258 GFI1|IFNG|IL1B|TNF|VDR 0.5844778948 0.0400402582407 GO:0003823 antigen binding molecular_function 16 54 80 29.6296296296 67.5 6.94777394355 1.60669877131e-07 6.73457179793e-06 CD1C|CD1D|CD209|CD48|FCN1|IL7R|LAG3|LCK|LILRA1|LILRA2|LILRB4|SKAP1|SLAMF1|SLC7A5|TAP1|TAP2 0.722094355312 0.124768349367 GO:0007186 G-protein coupled receptor protein signaling pathway biological_process 55 359 1127 15.3203342618 31.8544809228 6.94379324966 2.12539042789e-09 1.1776304903e-07 APOE|C3AR1|C5AR1|CCR1|CCR2|CCR3|CCR4|CCR5|CCR6|CCR7|CCR9|CCRL2|CD3E|CNR2|CXCR3|CXCR4|CXCR5|CXCR6|CYSLTR1|EREG|FPR1|FPR2|FPR3|GNG8|GNGT2|GP1BA|GPR132|GPR141|GPR15|GPR171|GPR174|GPR18|GPR183|GPR31|GPR55|GPR65|GPR68|GPR82|GPR84|HTR7|INSL3|LPAR5|P2RY10|P2RY13|PLEK|PMCH|PNOC|PTAFR|RGS1|RGS18|RGS19|S1PR4|SPHK1|SUCNR1|XCR1 0.6916183768 0.145026994607 GO:0051043 regulation of membrane protein ectodomain proteolysis biological_process 6 10 20 60.0 50.0 6.89486513955 1.18770858828e-05 0.000364211826002 extracellular region APOE|IFNG|IL10|IL1B|TIMP1|TNF 0.574381087167 0.0890167420447 GO:0031225 anchored to membrane cellular_component 16 56 142 28.5714285714 39.4366197183 6.75279914842 2.80799707968e-07 1.15083308885e-05 BST2|CD14|CD2|CD48|CD52|CD58|DPEP2|DPEP3|FOLR2|MMP25|OTOA|PLAUR|SEMA7A|VNN1|VNN2|VNN3 0.663557946938 0.178796689039 GO:0009986 cell surface cellular_component 33 177 299 18.6440677966 59.1973244147 6.65110403698 2.62267079672e-08 1.25402518465e-06 ADA|BACE2|CCR5|CD226|CD27|CD4|CD53|CD6|CD74|CD8A|CLEC17A|CLEC2D|CXCR4|FLT3|ICAM1|IL2RA|IL2RG|MMP25|NFAM1|NOD2|PDLIM2|PLAU|PLAUR|PTPRC|SLAMF1|TGFB1|TIGIT|TLR2|TNF|TNFRSF12A|TNR|TREML1|TREML2 0.719425014455 0.164529547321 GO:0046427 positive regulation of JAK-STAT cascade biological_process 9 22 36 40.9090909091 61.1111111111 6.58398657993 4.28920837965e-06 0.000145720211003 AGAP2|HCLS1|IFNG|IL12A|IL12B|IL23A|LCK|LIF|LYN 0.614598840667 0.150843120245 GO:0045730 respiratory burst biological_process 6 11 12 54.5454545455 91.6666666667 6.49505207238 2.47016233621e-05 0.0007102404401 CD52|CYBA|CYBB|NCF1|NCF2|PRKCQ 0.822774430167 0.0434784776572 GO:0048872 homeostasis of number of cells biological_process 15 53 61 28.3018867925 86.8852459016 6.48855769917 7.57377740312e-07 2.85899024194e-05 CD7|CORO1A|CSF1|FOXP3|HMOX1|IL2RA|IL7R|NCKAP1L|PIK3CD|SASH3|TGFB1|TNFRSF13B|TNFRSF13C|TNFSF13B|TNFSF14 0.793659160467 0.0977084976331 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor molecular_function 5 8 14 62.5 57.1428571429 6.45433368833 5.24897848666e-05 0.0013607291619 CYBA|CYBB|KMO|NCF1|NCF2 0.8012556604 0.0628391870251 GO:0043020 NADPH oxidase complex cellular_component 5 8 9 62.5 88.8888888889 6.45433368833 5.24897848666e-05 0.0013607291619 immune system process CYBA|CYBB|NCF1|NCF2|NCF4 0.8372433564 0.040238202432 GO:0043065 positive regulation of apoptosis biological_process 58 423 543 13.7115839243 77.9005524862 6.18710147251 4.53254465945e-08 2.10486156667e-06 APOE|ARHGAP4|BTK|CASP1|CASP10|CASP4|CD2|CD27|CD28|CD3E|CD40LG|CD5|CD70|CRTAM|CTLA4|ESR2|FASLG|FGD2|FGD3|GZMA|GZMB|HMOX1|IFI16|IFNG|IL10|IL12A|IL12B|IL18|IL1B|IL2RA|INPP5D|LCK|LEF1|LTA|MNDA|MX1|NCF2|NLRC4|NLRP3|NOD1|PMAIP1|PTPRC|RIPK3|RUNX3|SLAMF7|SPI1|SPN|STK17A|TGFB1|TLR2|TNF|TNFRSF8|TNFRSF9|TNFSF14|TNFSF8|UBD|VAV1|VDR 0.733293790362 0.128228544015 GO:0042554 superoxide anion generation biological_process 5 9 14 55.5555555556 64.2857142857 5.99788615967 0.000111819744477 0.00268825493705 CYBA|CYBB|NCF1|NCF2|SOD2 0.7656257402 0.137890910435 GO:0034105 positive regulation of tissue remodeling biological_process 5 10 16 50.0 62.5 5.60725036785 0.000211762403073 0.00483867721004 IL12B|IL15|IL18|IL23A|VDR 0.6393509668 0.156878602014 GO:0030155 regulation of cell adhesion biological_process 24 131 198 18.320610687 66.1616161616 5.55927291175 2.86867578369e-06 9.902300633e-05 ADA|ADAMDEC1|ARHGDIB|CSF1|CYTH4|CYTIP|FERMT3|FXYD5|ICAM1|IFNG|IL12A|IL12B|IL18|IL1B|ITGAL|LEF1|NCKAP1L|PLAU|SPN|SPOCK2|TGFB1|TNF|TNR|VAV1 0.706675258542 0.156194505243 GO:0009306 protein secretion biological_process 9 29 37 31.0344827586 78.3783783784 5.39447359156 5.73078630904e-05 0.00147673555389 CD40LG|LAX1|LCP2|LYN|NLRC4|NLRP3|PLEK|POU2F2|TNFSF13B 0.747822480222 0.133361071879 GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process 8 24 35 33.3333333333 68.5714285714 5.36525451762 8.42286137012e-05 0.00207517443298 AIF1|ICAM1|IFNG|IL1B|KLRK1|SOD2|TLR2|TNF 0.628572286875 0.130129959408 GO:0004715 non-membrane spanning protein tyrosine kinase activity molecular_function 10 35 41 28.5714285714 85.3658536585 5.33384944179 4.93084051169e-05 0.00133453146763 BLK|BTK|FGR|HCK|ITK|JAK3|LCK|LYN|SYK|ZAP70 0.7674328169 0.141971147269 GO:0050709 negative regulation of protein secretion biological_process 5 11 26 45.4545454545 42.3076923077 5.26730813976 0.000367646386166 0.00761848289792 FOXP3|IL10|NR1H3|SRGN|TNF 0.6170880616 0.13693566206 GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process 8 25 49 32.0 51.0204081633 5.20449585898 0.000116913243947 0.00280027825483 ARRB2|CD74|GPR55|IL1B|NOD1|NOD2|SEMA7A|TNF 0.700287151625 0.117317365858 GO:0018108 peptidyl-tyrosine phosphorylation biological_process 10 37 51 27.027027027 72.5490196078 5.10164149076 8.31603222051e-05 0.00205670452044 ABI3|BTK|IFNG|IL12RB1|JAK3|LCK|LIF|LYN|SYK|ZAP70 0.7221602626 0.169931799009 GO:0001816 cytokine production biological_process 8 26 34 30.7692307692 76.4705882353 5.0520820315 0.000159403781028 0.00374845685441 CD226|CD4|FOXP3|ITK|NFATC2|NLRP3|NOD2|PTAFR 0.790003746 0.107043547084 GO:0051353 positive regulation of oxidoreductase activity biological_process 7 21 35 33.3333333333 60.0 5.01810488098 0.000236775589748 0.00528853436617 APOE|FCER2|IFNG|IL1B|NOD2|TNF|VDR 0.582224160143 0.0910162256843 GO:0050817 coagulation biological_process 46 358 487 12.8491620112 73.5112936345 5.00160778552 8.50340402629e-06 0.000271730064305 APBB1IP|ARRB2|CD2|CD244|CD48|CD58|CD84|DOK2|EHD1|FCER1G|FGR|GP1BA|IL10RA|INPP5D|IRF1|ITGAL|ITGAM|ITGAX|ITGB2|LCK|LCP2|LYN|NFE2|PDE6G|PIK3R5|PLAU|PLAUR|PLEK|PRKCQ|RAC2|RASGRP1|SELL|SELPLG|SERPINA1|SIRPA|SLC16A3|SLC7A5|SLC7A7|SPN|SRGN|SYK|TGFB1|TIMP1|TMSB4X|VAV1|WAS 0.740681479043 0.157831762763 GO:0005765 lysosomal membrane cellular_component 18 96 179 18.75 53.6312849162 4.92391966227 3.56425570721e-05 0.000989560025378 CD1D|CD68|DRAM1|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|HPSE|LAMP3|LAPTM5|SLC15A3 0.768889423889 0.126111860228 GO:0042107 cytokine metabolic process biological_process 5 13 19 38.4615384615 68.4210526316 4.69987030238 0.000918687272733 0.0174986380922 CD28|CEBPE|IL12B|IL18|NOD1 0.6373658724 0.0989872997853 GO:0042379 chemokine receptor binding molecular_function 6 18 58 33.3333333333 31.0344827586 4.64527823353 0.000671068640265 0.0131066507501 immune system process CCL22|CCR2|CXCL13|CXCL16|XCL1|XCL2 0.679681893333 0.109145307599 GO:0051701 interaction with host biological_process 10 43 68 23.2558139535 63.2352941176 4.4928110299 0.000321720171401 0.00676450718695 CCR5|CD209|CD4|CXCR4|IFIT1|TAP1|TAP2|TGFB1|TLR2|TLR7 0.7321330716 0.132073835252 GO:0045121 membrane raft cellular_component 20 122 180 16.393442623 67.7777777778 4.49203863945 9.86258234736e-05 0.00242064521111 BIRC3|BTK|CARD11|CD14|CD226|CD28|CD4|CD48|CD79A|FASLG|HCK|HMOX1|LAX1|LCK|LYN|NFAM1|PTPRC|TNF|TNFRSF1B|TNR 0.7633587117 0.145393332965 GO:0006909 phagocytosis biological_process 8 31 42 25.8064516129 73.8095238095 4.39157663848 0.000603591054596 0.0118424931836 CD14|CEBPE|CORO1A|HCK|IRF8|NR1H3|UNC13D|VAV1 0.747088774375 0.191450990863 GO:0032844 regulation of homeostatic process biological_process 18 108 159 16.6666666667 67.9245283019 4.34004103962 0.000174868464323 0.00406766103497 ADA|FCER1G|HMGB2|IFNG|IL1B|IL2RA|INPP5D|LCK|LYN|MAFB|NCKAP1L|NR1H3|PTPRC|SPI1|TGFB1|TNF|XCL1|XCR1 0.664906513556 0.175125816766 GO:0007229 integrin-mediated signaling pathway biological_process 10 45 60 22.2222222222 75.0 4.31375915334 0.000476075924514 0.00963344856658 ADAMDEC1|ITGAL|ITGAM|ITGAX|ITGB2|ITGB7|PLEK|SEMA7A|SYK|VAV1 0.8088059586 0.0977454082412 GO:0009593 detection of chemical stimulus biological_process 7 26 41 26.9230769231 63.4146341463 4.25300162758 0.00100874617833 0.0184769378716 LY96|NOD2|PLCB2|RTP4|SOD2|TLR2|TLR6 0.734606403429 0.111365936054 GO:0004869 cysteine-type endopeptidase inhibitor activity molecular_function 7 26 45 26.9230769231 57.7777777778 4.25300162758 0.00100874617833 0.0184769378716 CARD16|CD27|CST6|CST7|LEF1|SERPINB9|TNFSF14 0.702107349714 0.202679397353 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade biological_process 8 33 44 24.2424242424 75.0 4.165217002 0.000947129282347 0.0179551233996 CARD9|CD27|DUSP22|IL1B|LYN|NOD1|NOD2|TNF 0.60811946325 0.125456562729 GO:0030097 hemopoiesis biological_process 12 63 79 19.0476190476 79.746835443 4.07969106174 0.000602966124652 0.0118424931836 CRIP2|CSF1|FLT3|HHEX|IFI16|IKZF1|IL10|LCK|LYL1|RUNX1|SOD2|TRIM22 0.651910465333 0.134546856484 GO:0008037 cell recognition biological_process 8 34 74 23.5294117647 45.9459459459 4.05857578116 0.00116956968245 0.0210881907827 ATP8B3|CD209|CD226|CD5|CLEC7A|CRTAM|DOCK2|NCR3 0.787874954375 0.096521372465 GO:0071260 cellular response to mechanical stimulus biological_process 9 41 43 21.9512195122 95.3488372093 4.04613551095 0.000997210426109 0.0184769378716 CASP1|CASP5|CYBA|IL1B|IRF1|TLR7|TLR8|TNFRSF8|TNFSF14 0.722555771556 0.10112662439 GO:0007267 cell-cell signaling biological_process 38 318 637 11.9496855346 49.9215070644 4.04409596604 0.000273008281579 0.00578741693791 APOE|BST2|CCL22|CCR1|CCR5|CD33|CD70|CD80|CD86|CXCL13|EREG|ESR2|FASLG|FCRL2|GAL3ST4|GNG8|GNGT2|GRAP2|HTR7|IL10|IL15|IL18|IL1B|INSL3|ITGB2|LILRB1|LILRB2|LTA|LTB|PLCB2|PMCH|PNOC|S100A9|SH2D1A|TNFSF8|TNFSF9|TSPAN32|XCL1 0.69074615 0.145238207856 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process 18 116 142 15.5172413793 81.6901408451 3.99310385389 0.000434433516189 0.00891659251828 APOL3|BST2|CARD11|CARD9|CASP1|CASP10|FASLG|HMOX1|IL1B|LGALS9|NOD1|NOD2|PIM2|SLC20A1|TLR6|TNF|TRAF1|UBD 0.688415779667 0.119119746235 GO:0005178 integrin binding molecular_function 10 49 78 20.4081632653 62.8205128205 3.98425723667 0.000970456694775 0.0182641924697 ADAMDEC1|CD226|FCER2|FERMT3|ICAM1|ICAM3|LYN|SEMA7A|SYK|TNR 0.6865721042 0.163488427823 GO:0005100 Rho GTPase activator activity molecular_function 6 22 31 27.2727272727 70.9677419355 3.97834766881 0.00216014261144 0.0367908194112 ARHGAP15|ARHGAP4|DOCK2|GMIP|MYO9B|NCKAP1L 0.737439226333 0.178298122891 GO:0005057 receptor signaling protein activity molecular_function 14 83 113 16.8674698795 73.4513274336 3.87541341432 0.000790730483276 0.0153048433869 CD19|CD3E|DOK2|FCGR1A|IFITM1|LYN|MAP3K8|MAP4K1|NCR1|PLK3|RGS14|RIPK3|SYK|TYROBP 0.686618080071 0.156600874795 GO:0050764 regulation of phagocytosis biological_process 5 17 24 29.4117647059 70.8333333333 3.85564642038 0.00355826001477 0.0569939662415 immune system process|positive regulation of immune system process|regulation of cytokine production|regulation of immune response CLEC7A|FCER1G|NCKAP1L|NOD2|TGFB1 0.8050555836 0.0774929757196 GO:0008305 integrin complex cellular_component 6 23 30 26.0869565217 76.6666666667 3.8362511724 0.00276527749357 0.04513240511 plasma membrane ITGAL|ITGAM|ITGAX|ITGB2|ITGB7|LYN 0.795515617333 0.155084276257 GO:0051101 regulation of DNA binding biological_process 7 30 39 23.3333333333 76.9230769231 3.76796198165 0.00249113802633 0.0409167836131 GZMA|HMGB2|HMOX1|IRF4|LEF1|SP100|TGFB1 0.644574813714 0.191947480348 GO:0035591 signaling adaptor activity molecular_function 11 60 64 18.3333333333 93.75 3.75510956979 0.00140114784941 0.0247453060682 ARHGAP4|CD28|DOK2|FCRL2|GRAP2|SH2D1A|SH2D2A|SKAP1|SLA|SLA2|TRAT1 0.764013562364 0.0715181189205 GO:0045766 positive regulation of angiogenesis biological_process 8 38 57 21.0526315789 66.6666666667 3.66899127196 0.00250623007213 0.0411123636991 BTG1|C3AR1|C5AR1|CCR3|HMOX1|IL1B|RUNX1|SPHK1 0.5900053685 0.135219214083 GO:0051100 negative regulation of binding biological_process 7 32 38 21.875 84.2105263158 3.55564504002 0.00368057347519 0.0585174920748 ARRB2|GZMA|HMOX1|IFIT1|IFIT2|LEF1|SP100 0.622244812714 0.119496147717 GO:0030168 platelet activation biological_process 23 178 238 12.9213483146 74.7899159664 3.53920238945 0.0016771643326 0.0291415767616 ARRB2|CD40LG|FCER1G|FGR|GP1BA|LCK|LCP2|LYN|PDE6G|PIK3R5|PLEK|PLSCR1|PRKCQ|RAC2|RASGRP1|SERPINA1|SRGN|SYK|TGFB1|TIMP1|TMSB4X|TREML1|VAV1 0.695734894565 0.140596768712 GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process 11 64 86 17.1875 74.4186046512 3.50481817637 0.00240419078921 0.0399851788702 CARD11|ICAM1|IL1B|NOD1|NOD2|SPHK1|TGFB1|TLR2|TNF|TNFRSF8|TRAF1 0.680590342545 0.135378550512 GO:0048662 negative regulation of smooth muscle cell proliferation biological_process 5 20 23 25.0 86.9565217391 3.37885918231 0.00758847673478 0.103061217696 extracellular space|positive regulation of immune system process|regulation of cytokine production|regulation of immune effector process|regulation of immune response|regulation of leukocyte activation HMOX1|IFNG|IL12A|IL12B|IL15 0.6409671592 0.107175633362 GO:0001906 cell killing biological_process 5 20 39 25.0 51.2820512821 3.37885918231 0.00758847673478 0.103061217696 APOL1|CRTAM|GNLY|HAMP|SLAMF7 0.728604753 0.127374864618 GO:0032088 negative regulation of NF-kappaB transcription factor activity biological_process 7 34 39 20.5882352941 87.1794871795 3.35956569138 0.00525829770334 0.0735478042797 ARRB2|FOXP3|NLRC3|NLRC5|NLRP3|NOD2|TRIM21 0.681945633 0.082062077367 GO:0048469 cell maturation biological_process 10 59 83 16.9491525424 71.0843373494 3.28972064812 0.00414482134682 0.0607972403803 BFSP2|BTK|CDC25B|EREG|ESR2|INSL3|KCNE1|POU2F2|RUNX3|TIMP1 0.5958653888 0.166212632522 GO:0005764 lysosome cellular_component 20 156 212 12.8205128205 73.5849056604 3.25858662492 0.00281446287827 0.0456466278373 ADA|CD74|CTSA|CTSC|CTSS|CTSZ|GM2A|HLA-DMA|HLA-DOB|HLA-DRA|IFI30|IL4I1|KCNE1|LAPTM5|NPC2|PRF1|RNASE2|SRGN|TLR7|UNC13D 0.6910984518 0.200522876201 GO:0009581 detection of external stimulus biological_process 8 44 83 18.1818181818 53.0120481928 3.17254061691 0.00645621343337 0.0888589716682 CACNA1F|CD1D|CLEC7A|GNGT2|NLRC4|NOD1|NOD2|PITPNM1 0.68484408775 0.137695460456 GO:0043406 positive regulation of MAP kinase activity biological_process 16 118 160 13.5593220339 73.75 3.15776902872 0.00406452648056 0.0607972403803 C5AR1|CD74|CXCR4|FPR1|IL1B|IL1RN|MAP4K1|MAPKAPK2|NOD1|NOD2|PDE6G|PTPRC|SYK|TGFB1|TLR6|TNF 0.695871793937 0.127572834931 GO:0046983 protein dimerization activity molecular_function 49 499 705 9.81963927856 70.780141844 3.12743645639 0.00283446087015 0.0459132871187 ALOX5AP|APOE|BATF|BATF2|BATF3|BST2|CARD9|CCR2|CD2|CD247|CD28|CD3D|CD3E|CD3G|CD4|CD8A|CEBPE|CORO1A|CR2|CSF1|CSF1R|CYBA|CYBB|FOXP3|GPD1|GZMA|HHEX|HMOX1|IKZF1|IKZF3|IL12A|IL12B|KYNU|MYO9B|NCF4|NFE2|NLRC4|NOD1|NR1H3|PLEK|PTPRE|RENBP|RUNX1|SP100|TAP1|TGFB1|TLR2|TLR6|XCL1 0.705332408245 0.15058156325 GO:0005768 endosome cellular_component 35 331 489 10.5740181269 67.6891615542 3.09516343747 0.00419470974803 0.0610526525897 APOE|BACE2|BST2|CCR5|CD1A|CD1C|CD1D|CD4|CD68|CD74|CD79A|CD8B|CYTIP|FPR1|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|IL15|PRF1|RAP2B|SLA|SLA2|SNX20|TLR7|TNF|UNC13D|VOPP1 0.7351411062 0.160805632559 GO:0035556 intracellular signal transduction biological_process 85 968 1300 8.78099173554 74.4615384615 3.07592512337 0.00324930605148 0.0523702136387 ACAP1|AGAP2|APOE|ARHGAP15|ARHGAP25|ARHGAP30|ARHGAP4|ARHGAP9|ARHGDIB|ARL11|BLK|BTK|CCR1|CCR2|CCR3|CD209|CD80|CNR2|CXCR3|DOK1|DOK2|DOK3|FGD2|FGD3|FPR1|GMIP|GRAP2|HCLS1|HMGB2|HMOX1|HTR7|IFI16|INPP5D|INSL3|ITK|JAK3|LAX1|LY96|LYN|MAP4K1|MAPKAPK2|MYO9B|NFAM1|NLRC3|NMI|NOD1|NOD2|PIK3CD|PLCB2|PLCH1|PLEK|PMAIP1|PRKCQ|PSMB9|PTAFR|RAB15|RAB32|RAB33A|RAB37|RAB42|RAC2|RAP2B|RASGEF1B|RASGRP1|RGL4|RGS1|RGS19|RHOH|RIPK3|S1PR4|SOCS1|SP100|SPHK1|STAT4|STK17A|STK38|SYK|TAGAP|TLR8|TNF|TREML1|TYROBP|VAV1|XCR1|ZAP70 0.7004962138 0.149159839691 GO:0044440 endosomal part cellular_component 25 218 320 11.4678899083 68.125 3.04187975686 0.00487816375857 0.0686024990448 B2M|CD1A|CD1C|CD1D|CD68|EHD1|FGD2|HLA-A|HLA-DMA|HLA-DOA|HLA-DOB|HLA-DPA1|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRB1|HLA-DRB5|PRF1|RAP2B|SLA2|SNX20|TLR7|TLR8 0.74106695472 0.144620837456 GO:0008360 regulation of cell shape biological_process 8 46 74 17.3913043478 62.1621621622 3.02547483656 0.00848694254827 0.112838752109 ARHGAP15|CORO1A|ERMN|FGD2|FGD3|ICAM1|ITGB2|LST1 0.818402068625 0.135754829447 GO:2000242 negative regulation of reproductive process biological_process 5 23 37 21.7391304348 62.1621621622 2.98676051694 0.014031591654 0.166038357702 ADA|IFIT1|SP100|TNF|TNIP1 0.6052497702 0.068231108359 GO:0004629 phospholipase C activity molecular_function 5 23 37 21.7391304348 62.1621621622 2.98676051694 0.014031591654 0.166038357702 ACAP1|C3AR1|CCR5|PLCB2|PLCH1 0.7048565098 0.186425674544 GO:0017124 SH3 domain binding molecular_function 13 93 120 13.9784946237 77.5 2.96558696542 0.00850717428933 0.112898668805 CD3E|CYBA|HCLS1|INPP5D|LYN|MICAL1|NCF1|OSTF1|PLSCR1|PTPN22|SH2D2A|SH3BP1|SIRPA 0.722805203 0.199891152566 GO:0045834 positive regulation of lipid metabolic process biological_process 7 39 68 17.9487179487 57.3529411765 2.92687553422 0.0113707435947 0.143922382331 APOE|IFNG|IL1B|NOD2|NR1H3|TGFB1|TNF 0.573220536429 0.133866898094 GO:0043498 cell surface binding molecular_function 5 24 47 20.8333333333 51.0638297872 2.87033599991 0.016805982548 0.191665401674 immune system process|integral to plasma membrane|plasma membrane CD2|ICAM1|SELPLG|SPN|TLR2 0.8158922224 0.145315705205 GO:0042169 SH2 domain binding molecular_function 5 24 28 20.8333333333 85.7142857143 2.87033599991 0.016805982548 0.191665401674 LAX1|LCK|SIT1|SKAP1|SYNGR3 0.7362522076 0.132181542571 GO:0014823 response to activity biological_process 5 24 40 20.8333333333 60.0 2.87033599991 0.016805982548 0.191665401674 response to drug IL10|NCF2|SMTNL1|SOD2|TNF 0.613857592 0.146183138113 GO:0001948 glycoprotein binding molecular_function 6 32 52 18.75 61.5384615385 2.83518239595 0.0151446851454 0.176939262649 immune system process|plasma membrane CD4|CD5|ITGAM|ITGB2|LCK|PTPRC 0.853101600833 0.0819274218591 GO:0070851 growth factor receptor binding molecular_function 8 49 88 16.3265306122 55.6818181818 2.81898231111 0.0123811016655 0.148550206786 EREG|IL10|IL12A|IL12B|IL12RB1|IL1B|LYN|TYMP 0.6391634625 0.149697443824 GO:0006915 apoptosis biological_process 50 533 700 9.3808630394 76.1428571429 2.81522374676 0.00672593754127 0.0921781885964 ARHGAP4|CASP1|CASP10|CASP4|CASP5|CD14|CD27|CD40LG|CHAC1|CXCR4|DNASE1L3|DRAM1|DUSP22|FASLG|FGD2|FGD3|GPR65|GRAMD4|GZMA|GZMB|GZMH|GZMM|HMGB2|IFNG|IL1B|IL24|IL2RA|ITGB2|LCK|LEF1|LY86|NLRP3|NOD1|PDCD1|PMAIP1|PNMA5|PRF1|PRKCQ|PSMB9|RIPK3|SOD2|SRGN|STK17A|TNF|TNFRSF12A|TNFRSF1B|TNFSF9|TRIM69|VAV1|XAF1 0.67683146262 0.165285062944 GO:0046456 icosanoid biosynthetic process biological_process 5 25 38 20.0 65.7894736842 2.75988243004 0.0199213966841 0.223251068743 ALOX5AP|CD74|DPEP2|MAPKAPK2|SYK 0.7293648208 0.176201271225 GO:0042752 regulation of circadian rhythm biological_process 5 25 33 20.0 75.7575757576 2.75988243004 0.0199213966841 0.223251068743 ADA|ARNTL2|CASP1|NR1H3|PMCH 0.638599146 0.208461717949 GO:0009408 response to heat biological_process 7 42 77 16.6666666667 54.5454545455 2.698979696 0.0168819767061 0.192023188789 CD14|IL1B|LYN|MICB|PRKCQ|TFEC|TRPV2 0.721959867286 0.122741451967 GO:0001959 regulation of cytokine-mediated signaling pathway biological_process 7 42 68 16.6666666667 61.7647058824 2.698979696 0.0168819767061 0.192023188789 CD74|IFNG|IL1RN|NLRC5|PTPRC|SOCS1|SPHK1 0.661130505143 0.179178308986 GO:0019838 growth factor binding molecular_function 10 70 114 14.2857142857 61.4035087719 2.6753049486 0.0138635784198 0.164502571139 cytokine binding|plasma membrane CSF2RB|IL10RA|IL18R1|IL2RA|IL2RB|IL2RG|IL3RA|IL7R|IL9R|TRIM16 0.7212515732 0.178347148433 GO:0043028 caspase regulator activity molecular_function 6 34 38 17.6470588235 89.4736842105 2.66055560159 0.0201581036384 0.225512233944 immune system process CASP1|CD27|LEF1|NOD1|SERPINB9|TNFSF14 0.727876976833 0.171962356831 GO:0016444 somatic cell DNA recombination biological_process 5 27 29 18.5185185185 93.1034482759 2.55472416546 0.027230042239 0.278116966223 immune system process BCL11B|CD40LG|HMGB2|LEF1|TCF7 0.5949785184 0.211541267367 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function 12 93 132 12.9032258065 70.4545454545 2.54188609436 0.0181088887724 0.205255271336 ACY3|ADA|AMDHD1|APOBEC3A|APOBEC3H|CD101|PADI2|PADI4|VNN1|VNN2|VNN3|ZBP1 0.6089487415 0.125099619522 GO:0004197 cysteine-type endopeptidase activity molecular_function 8 54 75 14.8148148148 72.0 2.50677356366 0.0215616916802 0.239760068554 CASP1|CASP10|CASP4|CASP5|CTSC|CTSS|CTSW|CTSZ 0.682338995375 0.189722682107 GO:0060205 cytoplasmic membrane-bounded vesicle lumen cellular_component 6 36 51 16.6666666667 70.5882352941 2.49814031767 0.0261923836482 0.269652051753 ADA|SERPINA1|SRGN|TGFB1|TIMP1|TMSB4X 0.6421849705 0.12143371683 GO:0023057 negative regulation of signaling biological_process 30 302 440 9.93377483444 68.6363636364 2.49410252442 0.0171822398656 0.195094737612 negative regulation of cell communication ADA|ARRB2|CD3E|CD74|CHST11|CNR2|CTHRC1|ESR2|HHEX|IL18BP|IL1B|IL1RN|INPP5D|LEF1|LIF|NLRC5|NOD2|PLEK|PMCH|PTPN22|PTPRC|PTPRE|RGS1|RGS14|RGS18|RGS19|RHOH|SLA2|SOCS1|TRAT1 0.684570633733 0.152700154889 GO:0042060 wound healing biological_process 7 45 70 15.5555555556 64.2857142857 2.49012185905 0.0240526942766 0.251230002517 EREG|HMOX1|IL1B|PLAU|S100A8|TGFB1|TIMP1 0.616486944429 0.109896042839 GO:0061138 morphogenesis of a branching epithelium biological_process 9 65 125 13.8461538462 52.0 2.43281414379 0.0359211065745 0.341307735705 CSF1|CTSZ|CXCR4|HHEX|IL10|LEF1|RDH10|TGFB1|VDR 0.612116171111 0.161662888399 GO:0031099 regeneration biological_process 9 65 106 13.8461538462 61.320754717 2.43281414379 0.0359211065745 0.341307735705 APOE|LEF1|LIF|NINJ2|PLAU|PLAUR|PRKCQ|SOCS1|TGFB1 0.618853843333 0.131364186879 GO:0070482 response to oxygen levels biological_process 16 140 209 11.4285714286 66.985645933 2.41057543579 0.0231316331866 0.242197392084 ADA|CASP1|CXCR4|HMOX1|ICAM1|IL18|IL1B|LTA|NCF2|PLAU|PRKCQ|SERPINA1|SOD2|TGFB1|TNF|UCP2 0.69079548575 0.10912305248 GO:0008015 blood circulation biological_process 5 29 50 17.2413793103 58.0 2.36761040706 0.0360488190171 0.341307735705 C3AR1|HTR7|KCNE1|NFE2|XCL2 0.6073897254 0.159660604482 GO:0002020 protease binding molecular_function 5 30 39 16.6666666667 76.9230769231 2.27990560637 0.04104484643 0.378492119579 CD28|CD70|SELL|SERPINA1|SERPINB9 0.6882871624 0.135390479916 GO:0001067 regulatory region nucleic acid binding molecular_function 5 30 44 16.6666666667 68.1818181818 2.27990560637 0.04104484643 0.378492119579 BCL11B|LEF1|NLRC5|NR1H3|VDR 0.5960774454 0.191523056157 GO:0008289 lipid binding molecular_function 29 301 474 9.63455149502 63.5021097046 2.27585837916 0.0313454903657 0.311045565428 ADAP2|ALOX5AP|APOE|APOL1|APOL2|APOL3|BTK|CD1C|CD1D|DAPP1|ESR2|LYN|NCF1|NCF4|NPC2|NR1H3|OSBPL3|PLCB2|PLEK|PLEKHA4|PRAM1|PTAFR|RASGRP1|RBP5|S1PR4|SELL|SNX20|VDR|VNN1 0.694277751897 0.175500145585 GO:0008236 serine-type peptidase activity molecular_function 11 90 190 12.2222222222 47.3684210526 2.2362886661 0.0472400647974 0.427079297293 C1R|CFB|CPVL|CTSA|GZMA|GZMB|GZMH|GZMK|GZMM|PLAU|RHBDF2 0.710993968273 0.103844635839 GO:0010638 positive regulation of organelle organization biological_process 12 101 140 11.8811881188 72.1428571429 2.23002205712 0.038266039854 0.35464075701 ARPC2|CD28|EREG|FOXP3|GPR65|IL1B|NCKAP1L|PLEK|PMAIP1|PRKCQ|TGFB1|TNF 0.681375294833 0.151218999119 GO:0010648 negative regulation of cell communication biological_process 29 304 441 9.53947368421 68.9342403628 2.21911986076 0.032637989756 0.321891862299 negative regulation of signaling ADA|ARRB2|CD3E|CD74|CHST11|CNR2|CTHRC1|ESR2|HHEX|IL18BP|IL1B|IL1RN|INPP5D|LEF1|LIF|NLRC5|NOD2|PLEK|PMCH|PTPN22|PTPRC|PTPRE|RGS1|RGS14|RGS18|RGS19|RHOH|SLA2|SOCS1 0.680271796276 0.153544453633 GO:0030193 regulation of blood coagulation biological_process 5 31 45 16.1290322581 68.8888888889 2.19569643372 0.0464390160884 0.422798094289 APOE|GP1BA|PLAU|PLAUR|PLEK 0.6086746942 0.198562627112 GO:0015833 peptide transport biological_process 5 31 73 16.1290322581 42.4657534247 2.19569643372 0.0464390160884 0.422798094289 CD209|IL1RN|SLC15A3|TAP1|TAP2 0.6331593632 0.098662294228 GO:0048145 regulation of fibroblast proliferation biological_process 6 41 53 14.6341463415 77.358490566 2.13593111663 0.0461726678814 0.421264411554 CD74|EREG|LTA|PMAIP1|SOD2|SPHK1 0.581128132 0.18105719489 GO:0007623 circadian rhythm biological_process 6 41 64 14.6341463415 64.0625 2.13593111663 0.0461726678814 0.421264411554 ADA|ARNTL2|CASP1|HTR7|PMCH|PRF1 0.7214392475 0.154252479462 GO:0008083 growth factor activity molecular_function 10 82 166 12.1951219512 49.3975903614 2.12384318238 0.0417694440485 0.384350336897 CSF1|EREG|GMFG|IL10|IL12A|IL12B|IL1B|LIF|TGFB1|TYMP 0.6572725269 0.113473706302 GO:0042493 response to drug biological_process 21 211 316 9.95260663507 66.7721518987 2.08787722358 0.0462771175173 0.421919199964 response to activity ATP1A3|B2M|CARD9|CASP1|ICAM1|IFNG|IL10|IL1B|IL1RN|LCK|LTA|LYN|MVP|NCF2|NCKAP1L|NFATC2|SMTNL1|SOCS1|SOD2|TGFB1|TNF 0.630184651476 0.126310269227 GO:0051056 regulation of small GTPase mediated signal transduction biological_process 21 214 267 9.81308411215 80.1498127341 2.01911015459 0.0490031672362 0.435696204559 ARHGAP15|ARHGAP25|ARHGAP30|ARHGAP4|ARHGAP9|ARHGDIB|CSF1|CYTH4|FGD2|FGD3|GMIP|GPR55|MYO9B|PLEKHG7|RAC2|RASAL3|RASGEF1B|RASGRP1|RHOH|TAGAP|VAV1 0.74310133681 0.177796279975