Supplementary Table 1. Anthropometric and DXA-derived body composition variables by sex and age group. Age (years) All (18-65) 18-24 25-34 35-44 45-54 55-65 Females n 738 163 208 123 147 97 Height (cm) 165.9 ± 6.5 166.9 ± 6.9 166.3 ± 6.5 166.6 ± 6.1 165.8 ± 6.1 162.9 ± 6.2* Weight (kg) 63.5 (57.4-71.0) 60.5 (54.7-66.3) 63.8 (58.5-71.0)* 66.0 (59.3-72.3) 63.5 (57.9-72.9) 64.2 (57.4-71.2) Body mass index (kg/m2) 23.0 (21.1-25.6) 21.8 (19.9-23.2) 23.3 (21.3-25.6)* 23.3 (21.6-26.4) 23.2 (21.4-26.2) 24.0 (21.7-27.0) Waist circumference (cm) 72.2 (67.9-79.3) 68.6 (64.8-72.0) 71.8 (67.8-77.0)* 74.7 (68.8-80.5) 74.8 (69.7-82.2) 76.4 (70.4-84.4) Waist-Hip ratio 0.75 ± 0.06 0.73 ± 0.05 0.74 ± 0.05 0.75 ± 0.05 0.76 ± 0.06 0.77 ± 0.06 Waist-height ratio 0.44 (0.41-0.48) 0.41 (0.39-0.44) 0.43 (0.41-0.47)* 0.45 (0.41-0.48) 0.45 (0.42-0.49) 0.47 (0.43-0.51) Visceral adipose tissue (kg) 0.17 (0.07-0.36) 0.07 (0.02-0.14) 0.16 (0.07-0.30)* 0.22 (0.10-0.45) 0.24 (0.13-0.50) 0.43 (0.17-0.78)* Abdominal fat (kg) 1.10 (0.69-1.77) 0.80 (0.58-1.18) 1.11 (0.71-1.68)* 1.20 (0.69-1.93) 1.29 (0.77-2.03) 1.54 (1.00-2.34) Android-gynoid fat ratio 0.32 ± 0.13 0.26 ± 0.09 0.30 ± 0.11* 0.32 ± 0.13 0.34 ± 0.13 0.40 ± 0.14* Percentage body fat (%) 30.3 ± 7.9 27.7 ± 6.6 29.8 ± 7.6* 30.2 ± 8.6 31.3 ± 8.0 34.3 ± 7.9* Fat mass index (kg/m2) 6.8 (5.2-8.7) 5.9 (4.9-7.0) 6.8 (5.2-8.6)* 6.9 (5.1-8.8) 7.2 (5.6-9.4) 8.2 (6.1-10.1) Males n 677 153 212 146 85 81 Height (cm) 179.3 ± 7.2 179.8 ± 7.9 180.5 ± 6.7 178.3 ± 7.6 179.0 ± 5.6 177.5 ± 7.3 Weight (kg) 82.5 (74.7-91.9) 76.7 (69.8-85.5) 83.0 (76.5-90.2)* 83.3 (75.6-93.2) 86.8 (79.1-96.7) 84.2 (74.6-95.7) Body mass index (kg/m2) 25.8 (23.5-28.0) 24.1 (22.2-25.9) 25.8 (23.4-27.7)* 26.0 (24.1-28.6) 27.4 (25.5-29.6) 26.5 (24.7-29.2) Waist circumference (cm) 83.7 (78.2-92.0) 77.9 (74.8-82.8) 83.0 (78.2-88.77)* 85.2 (80.6-92.9)* 93.3 (85.1-99.8)* 92.2 (85.2-100.1) Waist-hip ratio 0.86 ± 0.07 0.81 ± 0.04 0.84 ± 0.05* 0.87 ± 0.06* 0.91 ± 0.07* 0.92 ± 0.07 Waist-height ratio 0.47 (0.44-0.51) 0.44 (0.41-0.46) 0.46 (0.43-0.50)* 0.48 (0.45-0.51)* 0.52 (0.48-0.56)* 0.52 (0.48-0.55) Visceral adipose tissue (kg) 0.43 (0.24-1.00) 0.21 (0.112-0.35) 0.37 (0.22-0.62)* 0.51 (0.31-1.09)* 1.14 (0.54-1.85)* 1.23 (0.66-1.83) Abdominal fat (kg) 1.30 (0.74-2.20) 0.79 (0.51-1.16) 1.20 (0.73-1.88)* 1.47 (0.91-2.26) 2.25 (1.42-3.31)* 2.19 (1.62-3.09) Android-gynoid fat ratio 0.51 ± 0.20 0.38 ± 0.12 0.46 ± 0.15* 0.54 ± 0.18* 0.67 ± 0.19* 0.69 ± 0.21 Percentage body fat (%) 22.3 ± 7.6 18.7 ± 5.6 21.2 ± 7.2* 23.0 ± 8.4 26.4 ± 7.0* 26.3 ± 6.8 Fat mass index (kg/m2) 5.4 (3.9-7.5) 4.2 (3.3-5.3) 5.1 (3.8-6.7)* 5.8 (4.2-7.9) 7.0 (5.1-9.1)* 7.3 (5.6-8.8) Study cohort characteristics by sex and age. Normally distributed variables represented by mean ± standard deviation. Non-normally distributed variables represented with median (25th percentile – 75th percentile). A bold * denotes p < 0.0063 versus preceding age group.