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["Supplementary Table S6: Somatic mutation identified by whole-exome sequencing in leukemic Pax5+/- mice before anti-IL6 treatment and after treatment at the time of relapse. "]
[]
[{"$nulls":3},"Leukemic Pax5+/- mice prior to treatment with anti-IL6",{"$nulls":6},"Leukemic Pax5+/- mice treated with anti-IL6 after relapse"]
[null,null,"Mouse ID","Gene","Mutation",null,"BAF","Sift",null,null,"Gene","Mutation",null,"BAF","Sift"]
[]
[null,"Responder","Y067","Pax5","p.Cys64Arg","C64R","0.31","deleterious",null,null,"Pax5","p.Cys64Arg","C64R","0.897","deleterious"]
[{"$nulls":3},"Jak1","p.Arg878His","R878H","0.061","deleterious",null,null,"Jak1","p.Arg878His","R878H","0.296","deleterious"]
[{"$nulls":3},"Ss18","p.Pro174Ser","P174S","0.077","deleterious",null,null,"Sh2b3","p.Trp191Ter*","W191*","0.9","NA","stop gain"]
[{"$nulls":3},"Ss18","p.Met173Val","M173V","0.061","tolerated",null,null,"Jak3","p.Arg653His","R653H","0.455","deleterious"]
[{"$nulls":3},"Ss18","p.Pro168Leu","P168L","0.059","deleterious",null,null,"Ss18","p.Pro174Ser","P174S","0.09","deleterious"]
[{"$nulls":3},"Sh2b3","p.Trp191Ter*","W191*","0.125","NA","stop gain",null,"Ss18","p.Met173Val","M173V","0.088","tolerated"]
[{"$nulls":10},"Ss18","p.Pro168Leu","P168L","0.071","deleterious"]
[]
[null,"Responder","Y004","Ptprk","p.Leu22Ile","L22I","0.105","tolerated",null,null,"Zbtb16","p.Gly372Trp","G372W","0.103","tolerated"]
[{"$nulls":10},"Muc4","p.Gln1319His","Q1319H","0.105","tolerated"]
[{"$nulls":10},"Stil","p.Leu374Val","L374V","0.51","tolerated"]
[{"$nulls":10},"Ccne1","p.Leu297Ile","L297I","0.103","tolerated"]
[{"$nulls":10},"Kat6a","p.Glu791Ter*","E791*","0.111","NA","stop gain"]
[{"$nulls":10},"Pou2af1","p.Pro129His","P129H","0.107","deleterious"]
[{"$nulls":10},"Ptch1","p.Glu1052Ter*","E1052*","0.13","NA","stop gain"]
[{"$nulls":10},"Kmt2d","p.Pro2509Thr","P2509Thr","0.118","no prediction"]
[{"$nulls":10},"Bcorl1","p.Gly169Val","G169V","0.107","deleterious"]
[]
[null,"Responder","T362","Itgav","p.Ala872Gly","A872G","0.548","tolerated",null,null,"Itgav","p.Ala872Gly","A872G","0.545","tolerated"]
[{"$nulls":3},"Itgav","p.Ala921Ser","A928S","0.632","deleterious",null,null,"Itgav","p.Ala921Ser","A921S","0.511","deleterious"]
[{"$nulls":3},"Ext2","p.Thr622Ala","T622A","0.76","tolerated",null,null,"Ext2","p.Thr622Ala","T622A","0.533","tolerated"]
[{"$nulls":3},"Ptk6","p.Ala355Ser","A355S","0.07","deleterious",null,null,"Stil","p.Leu374Val","L374V","0.595","tolerated"]
[{"$nulls":3},"Stil","p.Leu374Val","L374V","0.405","tolerated",null,null,"Stil","p.Met686Thr","M686T","0.519","tolerated"]
[{"$nulls":3},"Stil","p.Met686Thr","M686T","0.559","tolerated",null,null,"Stil","p.Val740Met","V740M","0.571","tolerated"]
[{"$nulls":3},"Stil","p.Val740Met","V740M","0.24","tolerated",null,null,"Stil","p.Lys748Arg","K748R","0.471","tolerated"]
[{"$nulls":3},"Stil","p.Lys748Arg","L748R","0.308","tolerated",null,null,"Stil","p.Arg942His","R942H","0.548","tolerated"]
[{"$nulls":3},"Stil","p.Arg942His","R942H","0.452","tolerated",null,null,"Mutyh","p.Gln5Arg","Q5R","0.444","tolerated"]
[{"$nulls":3},"Mutyh","p.Gln5Arg","Q5R","0.286","tolerated",null,null,"Mutyh","p.Gln284Glu","Q248E","0.484","tolerated"]
[{"$nulls":3},"Mutyh","p.Gln284Glu","Q248E","0.455","tolerated",null,null,"Fanca","p.Met943Thr","M943T","0.44","tolerated"]
[{"$nulls":3},"Mrps15","p.Pro821Ser","P821S","0.07","deleterious",null,null,"Fanca","p.Leu599Phe","L599F","0.45","tolerated"]
[{"$nulls":3},"Fanca","p.Met943Thr","M943T","0.519","tolerated",null,null,"Fanca","intron variant",null,"0.2","NA"]
[{"$nulls":3},"Fanca","p.Leu599Phe","L599F","0.38","tolerated",null,null,"Fanca","intron variant",null,"0.222","NA"]
[{"$nulls":3},"Fanca","intronic variant","Gm20388 missense","0.125","NA",null,null,"Fanca","p.Ile323Thr","I323T","0.455","tolerated"]
[{"$nulls":3},"Fanca","p.Ile323Thr","I323T","0.377","tolerated",null,null,"Fanca","p.Asn310Asp","N310D","0.484","tolerated"]
[{"$nulls":3},"Fanca","p.Asn310Asp","N310D","0.426","tolerated",null,null,"Fanca","p.Met147Val","M147V","0.446","deleterious"]
[{"$nulls":3},"Fanca","p.Met147Val","M147V","0.579","deleterious",null,null,"Fanca","p.Leu43Val","L43V","0.5","tolerated"]
[{"$nulls":3},"Fanca","p.Leu43Val","L43V","0.482","tolerated",null,null,"Fanca","p.Thr23Ala","T23A","0.258","tolerated"]
[{"$nulls":3},"Fanca","p.Thr23Ala","T23A","0.188","tolerated",null,null,"Fanca","p.Pro15Ser","P15S","0.16","tolerated"]
[{"$nulls":3},"Muc4","p.Ser472Thr","s479S","0.056","deleterious",null,null,"Ss18","p.Pro174Ser","P174S","0.105","deleterious"]
[{"$nulls":3},"Atrx","p.Val1953Met","V1953M","1.0","tolerated",null,null,"Ss18","p.Met173Val","M173V","0.103","tolerated"]
[{"$nulls":3},"Mpl","p.Gly249Ser","G249S","0.563","deleterious",null,null,"Ss18","p.Ser148Arg","S148R","0.111","tolerated"]
[{"$nulls":3},"Pold1","p.Ser576Gly","S576G","0.474","tolerated",null,null,"Atrx","p.Val1953Met","V1953M","1.0","tolerated"]
[{"$nulls":3},"Fanca","p.Met833Val","M833V","0.353","tolerated",null,null,"Mpl","p.Gly249Ser","G249S","0.385","deleterious"]
[]
[null,"Non-responder","T812","Ptpn11","p.Ser506Leu","S506L","0.765","deleterious",null,null,"Ptpn11","p.Ser506Leu","S506L","0.901","deleterious"]
[{"$nulls":3},"Jak3","p.Arg653His","R653H","0.238","deleterious",null,null,"Jak3","p.Arg653His","R653H","0.32","deleterious"]
[{"$nulls":3},"Jak3","p.Val674Met","V674M","0.478","tolerated",null,null,"Jak3","p.Val674Met","V674M","0.367","tolerated"]
[{"$nulls":3},"Tcf12","p.Leu339Pro","L339P","0.29","deleterious",null,null,"Tcf12","p.Leu339Pro","L339P","0.413","deleterious"]
[]
[null,"Non-responder","T999","Sh2b3","p.Ser416Pro","S416P","0.793","tolerated",null,null,"Sh2b3","p.Ser416Pro","S416P","0.353","tolerated"]
[{"$nulls":3},"Thrap3","p.Ser11Pro","S11P","0.11","deleterious",null,null,"Cdh11","p.Ile100Phe","I100F","0.065","deleterious"]
[{"$nulls":10},"Npm1","p.Asp8Tyr","D8Y","0.167","deleterious"]
[{"$nulls":10},"Muc4","p.Gln1319His","Q1319H","0.083","tolerated"]
[]
[null,"Non-responder","T516","Nras","p.Gly13Asp","G13D","0.298","deleterious",null,null,"Nras","p.Gly13Asp","G13D","0.914","deleterious"]
[{"$nulls":3},"Chd4","p.Arg806Cys","R806C","0.263","deleterious",null,null,"Chd4","p.Arg806Cys","R806C","0.393","deleterious"]
[{"$nulls":3},"Jak1","p.Leu793Ile","L793I","0.111","tolerated",null,null,"Ncor2","p.Gly2339Ter*","G2339*","0.167","NA","stop gain"]
[{"$nulls":3},"Prf1","p.Gly514Cys","G514C","0.105","deleterious",null,null,"Erbb3","p.Gly1147Val","G1147V","0.154","tolerated"]
[{"$nulls":3},"Znrf3","p.Leu586Ile","L586I","0.143","deleterious",null,null,"Etv5","p.Arg498His","R498H","0.188","tolerated"]
[{"$nulls":3},"Arhgap5","p.Pro728Thr","P728T","0.111","tolerated"]
[{"$nulls":3},"Etv5","p.Arg498His","r498H","0.188","tolerated"]
[]
[null,null,"recurrent between pre and post treatment"]
[null,"bold ","recurrent genes and mutations in different mice"]
[null,null,"deleterious predicted"]