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{"sheet":"Planilha1","index":0,"n_rows":781,"n_cols":2,"rows_kept":781}
["Supplementary Table 3. Variants of uncertain significance "]
["Gene - HGVS","n"]
["APC",61]
["c.-43A>C",1]
["c.1553C>T",2]
["c.1564A>G",1]
["c.1580G>C",1]
["c.1604C>T",1]
["c.1762G>A",1]
["c.1864T>C",1]
["c.1925T>C",1]
["c.2110G>A",1]
["c.2204C>T",1]
["c.2254C>G",1]
["c.2360G>A",1]
["c.2627G>A",1]
["c.2642C>T",1]
["c.2847G>T",1]
["c.2995C>G",1]
["c.3029G>A",1]
["c.302G>A",1]
["c.3173A>G",2]
["c.3275A>C",1]
["c.3386T>C",1]
["c.3511C>T",4]
["c.3625G>A",1]
["c.388A>G",1]
["c.4124A>C",1]
["c.4310A>G",1]
["c.4333A>G",1]
["c.4349G>T",1]
["c.4556A>G",1]
["c.4583T>C",1]
["c.460G>A",1]
["c.5026A>G",3]
["c.5092G>A",1]
["c.5690A>C",1]
["c.5801C>T",2]
["c.5816A>T",2]
["c.647G>A",1]
["c.673G>C",1]
["c.7399C>A",4]
["c.7639T>G",1]
["c.7786T>G",1]
["c.7916A>C",1]
["c.8023C>T",1]
["c.8141G>A",1]
["c.8161C>T",1]
["c.8389A>G",1]
["c.848G>A",1]
["c.8524T>G",1]
["c.899C>T",1]
["ATM",137]
["c.1049C>T",2]
["c.1236G>T",1]
["c.125A>G",1]
["c.1273G>T",2]
["c.1370G>A",1]
["c.1516G>T",1]
["c.1595G>A",3]
["c.1703G>T",2]
["c.1825G>C",1]
["c.2021A>G",1]
["c.2125-48T>C",1]
["c.2167G>T",1]
["c.2182T>A",1]
["c.2254C>G",1]
["c.2289T>A",11]
["c.2336T>C",1]
["c.2466+5G>T",1]
["c.2735A>G",1]
["c.2879C>A",1]
["c.2921+4A>C",1]
["c.2932T>C",5]
["c.2944C>T",1]
["c.295A>G",2]
["c.320G>A",2]
["c.3256C>T",1]
["c.334G>A",2]
["c.3398A>T",1]
["c.3407A>G",1]
["c.3872T>C",1]
["c.3934A>G",1]
["c.395C>T",1]
["c.4082A>G",1]
["c.4091A>G",2]
["c.4148C>T",4]
["c.4388T>G",4]
["c.4414T>G",5]
["c.4424A>G",1]
["c.4709T>C",1]
["c.5071A>C",1]
["c.5185G>C",5]
["c.55A>G",1]
["c.5761A>G",1]
["c.5890A>G",2]
["c.5975A>C",3]
["c.6067G>A",4]
["c.6176C>T",1]
["c.6185C>A",1]
["c.6343G>A",2]
["c.6537T>G",1]
["c.6543G>T",1]
["c.6554T>C",1]
["c.6677T>C",1]
["c.6820G>A",2]
["c.6848C>T",1]
["c.6975G>A",1]
["c.7061C>T",1]
["c.7187C>G",2]
["c.7269A>T",1]
["c.7313C>T",3]
["c.7375C>G",9]
["c.7696G>A",1]
["c.7740A>C",1]
["c.7871G>C",1]
["c.7880A>G",1]
["c.7993C>G",1]
["c.8156G>A",2]
["c.8187A>C",1]
["c.8495G>A",1]
["c.8560C>T",6]
["c.8790C>G",1]
["c.8843T>C",2]
["c.9086G>A",2]
["c.9166G>T",1]
["BARD1",33]
["c.1247T>G",5]
["c.1314+5G>A",1]
["c.1376A>G",1]
["c.1569-13C>G",1]
["c.160A>G",1]
["c.1610A>G",1]
["c.1886G>T",1]
["c.1906G>A",1]
["c.1915T>C",2]
["c.1973G>A",1]
["c.1977A>G",1]
["c.2125C>T",1]
["c.2155A>G",1]
["c.2206T>C",1]
["c.308G>A",1]
["c.353A>G",1]
["c.490C>G",1]
["c.491A>C",1]
["c.716T>A",1]
["c.722C>G",1]
["c.77T>G",1]
["c.841C>T",5]
["c.842C>T",2]
["BLM",58]
["c.114A>G",2]
["c.11T>C",1]
["c.1216A>G",1]
["c.1228C>T",1]
["c.14C>T",2]
["c.1888T>C",1]
["c.1972A>G",1]
["c.2106T>A",1]
["c.2474C>T",1]
["c.2497G>A",1]
["c.254G>C",2]
["c.2556-8T>C",1]
["c.2561G>A",1]
["c.2570T>C",1]
["c.2594A>G",1]
["c.274A>G",1]
["c.3098T>C",1]
["c.3340C>T",1]
["c.3427G>A",3]
["c.3556A>G",1]
["c.3625T>A",2]
["c.3991A>G",1]
["c.4076+4T>G",1]
["c.4148C>G",1]
["c.4196T>C",1]
["c.43C>T",5]
["c.532G>A",2]
["c.543C>A",12]
["c.572G>T",1]
["c.645C>G",1]
["c.819_821delGAA",3]
["c.934T>G",1]
["c.968A>G",2]
["BRCA1",32]
["c.-20+5T>C",1]
["c.103G>T",1]
["c.135-5T>C",1]
["c.179A>G",1]
["c.1846_1848delTCT",1]
["c.213-14C>G",1]
["c.2597G>A",1]
["c.2798G>C",1]
["c.3012G>A",1]
["c.3047A>G",1]
["c.3119G>C",2]
["c.3143G>A",1]
["c.314A>G",1]
["c.3586A>T",1]
["c.3691T>C",1]
["c.372C>G",1]
["c.3782T>C",1]
["c.4262A>G",1]
["c.4304A>G",1]
["c.4358-2725T>C",1]
["c.4729T>C",1]
["c.4733A>G",1]
["c.4935G>C",1]
["c.5129G>A",1]
["c.5348T>C",3]
["c.5425_5430delGTTGTG",1]
["c.5531T>G",1]
["c.591C>T",1]
["c.995G>A",1]
["BRCA2",86]
["c.1211A>G",1]
["c.1504A>C",1]
["c.1564G>C",1]
["c.172G>A",1]
["c.2233A>G",1]
["c.223G>C",1]
["c.2274T>G",1]
["c.231T>G",1]
["c.2491G>A",1]
["c.2560A>G",1]
["c.2576T>C",1]
["c.2589T>A",1]
["c.280C>T",2]
["c.2918C>T",1]
["c.2998A>C",1]
["c.3152T>C",1]
["c.3170A>G",1]
["c.3835A>G",1]
["c.383A>G",2]
["c.3908G>A",1]
["c.4023A>C",1]
["c.4183G>T",2]
["c.4366G>A",1]
["c.449A>G",2]
["c.5068_5073dupAAAAAA",1]
["c.5096A>G",2]
["c.5228G>A",1]
["c.5270A>G",2]
["c.5284T>G",1]
["c.5467A>G",1]
["c.5612G>A",1]
["c.561G>C",1]
["c.5674G>A",1]
["c.5729A>T",1]
["c.5885T>C",1]
["c.6024G>C",1]
["c.6095C>T",2]
["c.6386A>G",1]
["c.6554C>T",2]
["c.6988A>G",2]
["c.7426_7428delGAA",1]
["c.7481G>A",1]
["c.7618-10T>G",2]
["c.7712A>G",1]
["c.7994A>G",1]
["c.7A>G",2]
["c.8035G>T",1]
["c.8092G>A",1]
["c.811G>A",5]
["c.8351G>A",1]
["c.8482A>G",2]
["c.8518A>G",2]
["c.8524C>T",2]
["c.8754+9G>A",1]
["c.9078G>C",1]
["c.9109C>A",1]
["c.9242T>C",1]
["c.9337A>G",1]
["c.9442G>T",1]
["c.9501+3A>T",1]
["c.9502-12T>G",2]
["c.9510C>G",1]
["c.9677A>G",1]
["c.967G>A",1]
["c.9875C>T",1]
["c.9945delA",1]
["c.9986A>G",1]
["BRIP1",47]
["c.-22C>A",1]
["c.1000G>T",1]
["c.1014A>G",1]
["c.1131A>G",1]
["c.1336A>C",1]
["c.1341-3C>G",1]
["c.139C>G",3]
["c.1427C>G",1]
["c.1629-3T>C",2]
["c.1871C>T",1]
["c.1919T>C",1]
["c.2220G>T",4]
["c.2593C>T",1]
["c.266C>G",1]
["c.2830C>G",1]
["c.2876C>G",1]
["c.2914G>A",1]
["c.3148A>C",1]
["c.316C>T",1]
["c.3275C>A",2]
["c.3412G>A",1]
["c.3559G>A",1]
["c.3651G>T",4]
["c.3691A>G",1]
["c.3693A>G",2]
["c.439T>C",1]
["c.588C>G",2]
["c.728T>C",1]
["c.854A>G",3]
["c.887A>G",2]
["c.93+4_93+7delAGTA",1]
["c.991A>T",1]
["CDH1",24]
["c.1136C>T",1]
["c.1721T>G",1]
["c.1774G>A",3]
["c.2204C>A",1]
["c.2351G>A",1]
["c.2440-6C>G",6]
["c.2494G>A",1]
["c.2635G>A",1]
["c.269G>A",1]
["c.387+5G>A",1]
["c.417G>C",1]
["c.671G>A",1]
["c.778C>T",1]
["c.79C>T",1]
["c.949T>C",2]
["c.976A>G",1]
["CDK4",4]
["c.-195G>A",1]
["c.632+9C>T",1]
["c.661G>A",1]
["c.689T>C",1]
["CDKN2A",7]
["c.148C>A",1]
["c.160A>C",1]
["c.369T>A",1]
["c.9_32delGGCGGCGGGGAGCAGCATGGAGCC",2]
["n.21994171C>A",1]
["n.21994296G>A",1]
["CHEK2",48]
["c.-4C>T",1]
["c.-9G>C",1]
["c.1024G>A",1]
["c.1036C>T",4]
["c.1141A>G",3]
["c.1216C>T",1]
["c.1312G>T",3]
["c.1423T>A",2]
["c.1513T>C",1]
["c.1556G>T",4]
["c.1567C>A",1]
["c.319+3966G>A",1]
["c.320-5T>A",5]
["c.331G>T",1]
["c.336C>G",2]
["c.475T>C",2]
["c.503C>T",1]
["c.542G>A",1]
["c.592+3A>T",1]
["c.695G>T",1]
["c.715G>A",4]
["c.888T>G",1]
["c.904G>A",1]
["c.917G>C",1]
["c.953G>A",2]
["c.962A>C",2]
["EGFR",20]
["c.116C>T ",1]
["c.1816C>G",1]
["c.1837G>A",1]
["c.2024G>A",3]
["c.2033C>T",1]
["c.2485G>C ",1]
["c.2885G>A",1]
["c.3245T>G",4]
["c.3352G>A",1]
["c.3467A>C",3]
["c.509G>A",1]
["c.731G>A",1]
["c.797C>A ",1]
["FANCC",14]
["c.1069C>G",1]
["c.1374A>C",1]
["c.178G>A",1]
["c.202G>A",1]
["c.395C>G",1]
["c.413T>G",1]
["c.584A>T",1]
["c.668T>C",2]
["c.817G>A",3]
["c.839C>T",1]
["c.843+5G>A",1]
["MEN1",9]
["c.1180C>T",1]
["c.1633C>T",2]
["c.203C>T",1]
["c.236C>G",1]
["c.343C>G",2]
["c.409C>T",1]
["c.670-6C>G",1]
["MET",36]
["c.103A>T",1]
["c.1076G>A",1]
["c.1171G>A",1]
["c.1238G>A",1]
["c.1496A>G",1]
["c.1508T>A",1]
["c.1640G>A",1]
["c.1771C>T",1]
["c.1866G>C",1]
["c.1904A>G",1]
["c.1988C>T",2]
["c.2103-1G>T",1]
["c.2192G>A",1]
["c.236A>G",1]
["c.2879C>T",2]
["c.2962C>T",3]
["c.3049G>C",1]
["c.305G>A",2]
["c.3272C>T",3]
["c.3410G>C",1]
["c.362T>C",2]
["c.40C>T",1]
["c.4154C>G",1]
["c.467C>T",2]
["c.569A>G",1]
["c.71G>A",1]
["c.803C>T",1]
["MLH1",14]
["c.1154G>A",1]
["c.1360G>C",1]
["c.1392T>C",1]
["c.1453G>T",2]
["c.1500_1502delCAT",1]
["c.1615G>T",1]
["c.1876T>C",1]
["c.2107G>A",1]
["c.306+6C>T",1]
["c.5C>T",1]
["c.65G>C",1]
["c.884+39G>A",1]
["c.94A>G",1]
["MSH2",25]
["c.1045C>G",1]
["c.1130A>G",1]
["c.128A>G",1]
["c.138C>G",1]
["c.1563T>C",1]
["c.157G>T",1]
["c.1595T>C",1]
["c.1730T>C",1]
["c.1787A>G",1]
["c.1A>G",1]
["c.2005+8dupA",1]
["c.2008C>T",1]
["c.2009C>A",1]
["c.2111T>C",1]
["c.2417C>T",1]
["c.2606C>A",1]
["c.2785C>T",1]
["c.382C>G",2]
["c.435T>G",4]
["c.815C>T",2]
["MSH6",35]
["c.1120A>G",1]
["c.1321C>G",1]
["c.1406A>G",1]
["c.1651G>A",1]
["c.1661G>A",1]
["c.1730G>A",2]
["c.1932G>C",2]
["c.2180C>T",1]
["c.2347T>A",1]
["c.2667G>T",1]
["c.2693C>G",1]
["c.2752C>T",2]
["c.3019T>C",1]
["c.3160A>T",1]
["c.3245C>T",2]
["c.3260C>G",2]
["c.3270G>C",1]
["c.3307T>G",1]
["c.334A>G",1]
["c.3478G>A",1]
["c.34C>A",1]
["c.3524C>G",1]
["c.3961A>G",1]
["c.4002-10T>A",1]
["c.431G>T",2]
["c.650A>G",1]
["c.663A>C",2]
["c.923G>C",1]
["MUTYH",21]
["c.1070A>G",1]
["c.1289C>T",1]
["c.1310G>A",1]
["c.1508G>A",2]
["c.1599T>A",1]
["c.481G>C",3]
["c.568G>T",1]
["c.56G>A",1]
["c.650G>A",4]
["c.667A>G",1]
["c.690+3G>C",1]
["c.827G>A",1]
["c.932G>A",1]
["c.985G>A",2]
["NBN",28]
["c.1228A>G",1]
["c.1471G>A",1]
["c.171+4T>C",1]
["c.1912T>C",2]
["c.2060A>C",1]
["c.2140C>G",1]
["c.266G>A",1]
["c.283G>A",3]
["c.38-10T>A",1]
["c.511A>G",3]
["c.517A>G",2]
["c.628G>T",2]
["c.643C>T",7]
["c.806G>C",1]
["c.97A>G",1]
["NF1",18]
["c.1370A>T",1]
["c.2032C>A",1]
["c.2896G>A",1]
["c.3989A>C",1]
["c.4199C>T",1]
["c.4265C>T",1]
["c.4592A>G",1]
["c.4619G>A",1]
["c.4880C>T",1]
["c.5843A>T",1]
["c.6514G>C",1]
["c.6574A>G",1]
["c.6710G>A",1]
["c.6943G>A",1]
["c.7028G>A",1]
["c.7150A>G",1]
["c.7450G>A",1]
["c.8332G>A",1]
["NF2",13]
["c.1113C>G",1]
["c.1340+8G>T",2]
["c.1387G>A",1]
["c.1540A>G",1]
["c.1699G>A",1]
["c.1724A>G",1]
["c.1737+1432G>A",1]
["c.349T>G",1]
["c.610G>C",1]
["c.817A>G",1]
["c.947T>G",2]
["PALB2",38]
["c.101G>A",1]
["c.1217C>T",1]
["c.1226A>G",1]
["c.1250C>A",1]
["c.1252A>G",1]
["c.1379A>G",1]
["c.1588C>T",1]
["c.194C>T",1]
["c.1982C>G",1]
["c.2135C>T",1]
["c.2258G>A",1]
["c.2379C>T",1]
["c.23C>T",2]
["c.2401G>A",1]
["c.2438T>C",1]
["c.2453T>C",2]
["c.2506G>A",2]
["c.2720A>G",1]
["c.2816T>G",3]
["c.2927G>C",1]
["c.3056T>C",1]
["c.3085A>G",1]
["c.3184A>G",1]
["c.3194C>G",1]
["c.3233G>C",1]
["c.3257G>A",1]
["c.3428T>A",2]
["c.560C>A",1]
["c.656A>G",4]
["PMS2",18]
["c.1004A>G",1]
["c.1243G>A",1]
["c.1437C>G",1]
["c.1593_1610dupACATGTGGACTCTCAGGA",1]
["c.194T>G",1]
["c.2167C>G",1]
["c.2186_2187delTC",1]
["c.2405G>A",1]
["c.2445G>A",1]
["c.2523G>A",2]
["c.451C>T",1]
["c.497T>C",1]
["c.53T>C",1]
["c.572A>G",1]
["c.714C>A",1]
["c.825A>T",1]
["c.983A>G",1]
["POLD1",18]
["c.1687-2A>G",1]
["c.189G>T",1]
["c.197C>G ",1]
["c.2052G>C ",3]
["c.2874G>A",1]
["c.2987C>T ",2]
["c.3157C>T",1]
["c.353C>T",2]
["c.455C>T",2]
["c.521G>A",1]
["c.674G>A",2]
["c.961G>A",1]
["POLE",31]
["c.1288G>A",1]
["c.1337G>A",1]
["c.139C>T",1]
["c.1534G>A ",1]
["c.154C>T",1]
["c.1645T>C",1]
["c.1741G>T",1]
["c.2089C>A",1]
["c.2090C>G ",1]
["c.2209A>G ",1]
["c.2645A>G",2]
["c.2683G>A",1]
["c.3539AGA[2]",1]
["c.3715C>G",1]
["c.3865C>T",1]
["c.4476C>G",1]
["c.4523G>A ",1]
["c.4754T>A ",1]
["c.4945A>G",1]
["c.5398G>A",1]
["c.5573G>A",1]
["c.5575C>G",1]
["c.5895delAGG ",1]
["c.6331-8C>T",1]
["c.6334C>T",1]
["c.6433C>T ",1]
["c.6445C>T",1]
["c.6581A>G",1]
["c.6674G>A",1]
["c.6674G>A ",1]
["PTEN",8]
["c.-701G>A",1]
["c.-921G>A",1]
["c.1078A>G",1]
["c.235G>A",1]
["c.256G>A",1]
["c.78C>T",1]
["c.882T>G",1]
["c.901G>A",1]
["RAD51C",12]
["c.1102C>T",1]
["c.32A>G",1]
["c.335G>C",1]
["c.3G>A",1]
["c.523G>A",1]
["c.571+4A>G",1]
["c.719T>C",1]
["c.760G>T",1]
["c.790G>A",3]
["c.870T>A",1]
["RAD51D",31]
["c.137C>G",1]
["c.146C>T",1]
["c.232T>G",1]
["c.263+1641C>T",1]
["c.26G>C",8]
["c.401A>G",1]
["c.480+4A>G",1]
["c.568G>A",1]
["c.70A>G",1]
["c.715C>T",1]
["c.716G>A",1]
["c.793G>A",1]
["c.80C>A",1]
["c.823C>T",1]
["c.83-3C>G",1]
["c.83-4T>A",1]
["c.862G>C",2]
["c.899G>A",1]
["c.904-3C>T",2]
["c.919G>A",1]
["c.932T>A",1]
["c.973G>A",1]
["RB1",10]
["c.1399C>G",1]
["c.2027T>C",1]
["c.2360G>A",1]
["c.2441A>G",1]
["c.59C>T",1]
["c.929G>A",4]
["c.940G>T",1]
["RECQL",26]
["c.1088A>G",3]
["c.1216+3A>G",1]
["c.1465A>G",3]
["c.1483G>C",5]
["c.1750C>T",1]
["c.1798-2A>T",1]
["c.1859C>G",2]
["c.371A>T",1]
["c.386G>A",1]
["c.406G>A",1]
["c.468T>G",2]
["c.487G>T",1]
["c.501+3A>G",1]
["c.518T>A",1]
["c.809G>A",1]
["c.86C>T",1]
["RET",28]
["c.1013C>T",1]
["c.1377G>T",1]
["c.1423C>T",2]
["c.1531G>A",1]
["c.1678C>T",2]
["c.1760-3C>T",1]
["c.1907C>T",1]
["c.1942G>A",3]
["c.1946C>T",1]
["c.2081G>A",1]
["c.2116G>A",1]
["c.2166G>T",1]
["c.2371T>A",1]
["c.2432C>G",1]
["c.2531G>A",1]
["c.2611G>A",1]
["c.3149G>A",2]
["c.452A>G",1]
["c.50_58dupTGCTGCTGC",1]
["c.785T>C",1]
["c.874G>A",1]
["c.961G>A",1]
["c.973G>A",1]
["STK11",16]
["c.1038C>T",3]
["c.1040C>T",1]
["c.1087A>G",1]
["c.1128G>T",1]
["c.1163A>G",1]
["c.1178A>G",1]
["c.188T>C",1]
["c.217T>C",1]
["c.465-3C>T",1]
["c.559G>A",1]
["c.613G>A",1]
["c.877G>A",1]
["c.911G>A",1]
["c.920+5G>A",1]
["TP53",11]
["c.285T>G",1]
["c.28G>A",1]
["c.417G>T",1]
["c.642T>G",1]
["c.66A>G",1]
["c.797G>A",1]
["c.869G>A",3]
["c.935C>G",1]
["c.993+303T>A",1]
["WT1",16]
["c.1048T>C",6]
["c.147C>G",1]
["c.190T>A",1]
["c.299C>G",1]
["c.376C>T",1]
["c.389C>T",2]
["c.526C>A",1]
["c.547C>T",2]
["c.634A>G",1]
["."]
["."]
["Total Geral",1033]