Supplementary Table 1. Cox regression results for costimulatory molecular-related genes							
gene	HR	z	pvalue	lower	upper		
TNFRSF18	1.767973183	4.223505316	2.41E-05	1.357162564	2.303135423		
LTBR	4.782327544	3.990428087	6.60E-05	2.217294385	10.31466859		
TNFRSF19	1.787609554	3.948357071	7.87E-05	1.339814103	2.385068131		
RELT	3.945629194	3.939419052	8.17E-05	1.993117204	7.8108752		
PDCD1	1.351912711	3.820324569	0.000133276	1.158156585	1.578083656		
CD27	1.413265216	3.817771756	0.000134662	1.183319407	1.687894713		
LTB	1.417456239	3.7015416	0.000214294	1.17838007	1.705037483		
TNFRSF1B	1.815705784	3.66909206	0.000243413	1.32028586	2.497025528		
TNFRSF8	1.525067473	3.62816618	0.000285442	1.214157043	1.915593053		
TNFSF13	0.319756528	-3.573797213	0.000351841	0.171099768	0.597570869		
FASLG	1.352154295	3.508099962	0.000451319	1.142410834	1.600406073		
TNFRSF11B	1.539225527	3.446715481	0.000567446	1.204462863	1.967030529		
ICOS	1.395019949	3.438397721	0.000585168	1.153895103	1.68653169		
TNFRSF21	2.141758709	3.430874769	0.000601638	1.386150762	3.309257906		
LTA	1.541419161	3.365210853	0.000764852	1.198042064	1.983213362		
TNFSF13B	1.433017602	3.301098579	0.00096307	1.157391206	1.77428292		
TNFRSF9	1.329247953	3.292189935	0.000994104	1.122066815	1.574683519		
TNFRSF4	1.532401733	3.129328401	0.001752064	1.172923985	2.002052223		
CD40LG	1.515194703	3.112976795	0.001852106	1.166389368	1.968309256		
TNFRSF1A	4.109266793	3.055304871	0.002248319	1.659729625	10.17399058		
TNFRSF17	1.450977861	2.950487538	0.003172728	1.133109773	1.858016587		
CD86	1.547615593	2.928099284	0.003410411	1.155339083	2.073083185		
TNF	1.427883929	2.777752033	0.005473637	1.110561428	1.835875498		
TNFSF14	1.566101978	2.752393442	0.00591614	1.137862482	2.155511273		
TNFRSF12A	1.659752324	2.716471845	0.006598181	1.151541679	2.392251908		
CTLA4	1.330891237	2.705246923	0.006825363	1.081933826	1.637134769		
CD70	1.227159626	2.582537052	0.009807683	1.050585513	1.433410921		
CD28	1.508383373	2.563926594	0.010349543	1.101667423	2.065251592		
TNFRSF13B	1.40990894	2.537498606	0.011164781	1.081324101	1.838341732		
TNFRSF11A	1.759735232	2.502020255	0.012348686	1.130252651	2.739801657		
TNFSF12	0.509588045	-2.376160999	0.017493828	0.292227137	0.888623754		
TNFSF10	1.35055109	2.321549702	0.020257195	1.047918085	1.740582849		
TNFRSF13C	0.60895854	-2.172198481	0.029840695	0.389244327	0.952693406		
TNFSF9	1.414822425	2.068945529	0.038551198	1.018446483	1.96546655		
TNFSF11	1.879930236	1.929472677	0.053672209	0.990074236	3.569568384		
CD80	1.350723627	1.812382731	0.069927079	0.975816253	1.869669942		
TNFSF15	1.598230302	1.787829511	0.073803518	0.955857927	2.672301005		
TNFRSF10C	1.178299318	1.751741805	0.079818215	0.980686379	1.415732197		
FAS	1.285503304	1.721521314	0.085156268	0.965812015	1.711014895		
TNFRSF14	1.708857039	1.714100806	0.086510214	0.926022843	3.153477694		
TMIGD2	0.700196111	-1.70683191	0.0878533	0.465033953	1.054276987		
EDA2R	1.420823577	1.64868659	0.099211859	0.935836376	2.157150211		
TNFRSF6B	1.631975358	1.627427576	0.103646319	0.904764789	2.943686138		
CD276	1.593641447	1.601475556	0.10927163	0.900938399	2.818941966		
CD274	1.341609915	1.585921602	0.112757095	0.933037553	1.929094021		
TNFSF18	1.744465996	1.268209723	0.204723066	0.73821594	4.122319017		
TNFSF8	1.237100029	1.21005274	0.226258656	0.876462948	1.746127986		
TNFRSF10A	1.172519236	1.169087458	0.242368396	0.897926925	1.53108379		
ICOSLG	1.283400447	1.050591769	0.293446123	0.805756387	2.044186971		
TNFRSF25	1.180638317	1.033722736	0.301265801	0.861750392	1.61752968		
EDA	1.255969513	0.950899492	0.3416554	0.785175083	2.009054352		
TNFSF4	1.192818168	0.924330002	0.355314527	0.82073887	1.733578408		
TNFRSF10D	1.086392521	0.749696879	0.453437287	0.874792504	1.349175609		
NGFR	1.046294322	0.597817539	0.549961686	0.902023869	1.213639513		
CD40	0.92670326	-0.471171349	0.637518377	0.675183156	1.271919958		
TNFRSF10B	0.888178119	-0.389264557	0.697080452	0.488872581	1.613631858		
EDAR	1.316413786	0.386611045	0.69904418	0.32667839	5.304744093		
HHLA2	1.085547332	0.169612445	0.865314935	0.420443765	2.802783887		
VTCN1	1.019237063	0.084677733	0.932517599	0.655746465	1.584216229		
PDCD1LG2	1.008975259	0.059179662	0.952809009	0.750519778	1.356434706