Supplementary Table S5: Results of the biological process category terms from GO enrichment analysis Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0009410~response to xenobiotic stimulus 27 16.875 2.18E-20 "RET, HDAC4, ABCB1, HSP90AB1, MAOB, SRC, AHR, HTR2A, TYMS, PTGS2, PNP, CCND1, TSPO, DRD2, SNCA, BCHE, ABCC1, JUN, ACE, ARG1, MMP2, P2RX7, ADAM17, APEX1, CDK1, PPARG, TOP1" 159 277 19453 11.9254138 5.95E-17 5.95E-17 5.42E-17 GOTERM_BP_DIRECT GO:0006468~protein phosphorylation 30 18.75 2.55E-18 "RET, CAMK2B, APP, GSK3B, PRKDC, SRC, AURKA, MYLK, IKBKB, ERBB2, AKT1, MAPK1, JAK3, JAK1, MAP2K1, SYK, CSNK2A1, DAPK1, PRKCD, DYRK1A, PRKCA, BRAF, TGFBR1, PTK2, P2RX7, CDK6, CDK5, CDK2, CDK1, FGFR1" 159 444 19453 8.266615672 6.98E-15 3.49E-15 3.18E-15 GOTERM_BP_DIRECT GO:0046777~protein autophosphorylation 21 13.125 3.12E-17 "PDGFRB, CAMK2B, PDGFRA, NTRK2, GSK3B, CSF1R, FLT1, SYK, DAPK1, FLT3, SRC, DYRK1A, EGFR, PTK2, AURKA, CDK5, KIT, ERBB2, KDR, AKT1, FGFR1" 159 182 19453 14.11683599 8.51E-14 2.84E-14 2.59E-14 GOTERM_BP_DIRECT GO:0043406~positive regulation of MAP kinase activity 16 10 4.99E-17 "PDGFRB, APP, FLT1, FLT3, SRC, MIF, HTR2A, EGFR, PIK3CG, VEGFA, P2RX7, KIT, ERBB2, TLR4, ELANE, FGFR1" 159 77 19453 25.42252716 1.36E-13 3.41E-14 3.11E-14 GOTERM_BP_DIRECT GO:0051897~positive regulation of protein kinase B signaling 20 12.5 7.14E-16 "PDGFRB, RET, PDGFRA, NTRK2, CSF1R, APP, FLT1, HSP90AB1, FLT3, SRC, F3, EGFR, TGFBR1, PIK3CG, PTK2, VEGFA, KIT, KDR, MET, FGFR1" 159 185 19453 13.22658508 1.82E-12 3.90E-13 3.56E-13 GOTERM_BP_DIRECT GO:0018108~peptidyl-tyrosine phosphorylation 14 8.75 9.12E-16 "PDGFRB, PDGFRA, CSF1R, FLT1, SYK, FLT3, SRC, DYRK1A, EGFR, PTK2, ERBB2, KDR, JAK3, FGFR1" 159 58 19453 29.53177185 2.43E-12 4.15E-13 3.78E-13 GOTERM_BP_DIRECT GO:0018105~peptidyl-serine phosphorylation 19 11.875 1.08E-14 "CAMK2B, GSK3B, SYK, CSNK2A1, PRKDC, SRC, PRKCD, DYRK1A, PRKCA, MAPK14, TGFBR1, AURKA, IKBKB, CDK5, CDK2, CDK1, AKT1, MAPK1, TOP1" 159 184 19453 12.63354526 2.94E-11 4.20E-12 3.83E-12 GOTERM_BP_DIRECT GO:0043066~negative regulation of apoptotic process 27 16.875 2.53E-13 "CSF1R, GSK3B, HSP90AB1, PRKDC, HDAC1, SRC, AKR1B1, MPO, EGFR, AURKA, IKBKB, ERBB2, KDR, AKT1, MCL1, SNCA, PDGFRB, HSPA5, DAPK1, BRAF, MIF, MMP9, TGFBR1, PTK2, VEGFA, CDK1, PPARD" 159 540 19453 6.117295597 6.92E-10 8.64E-11 7.88E-11 GOTERM_BP_DIRECT GO:0008284~positive regulation of cell proliferation 27 16.875 3.13E-13 "HDAC4, CSF1R, FLT1, FLT3, HDAC1, ODC1, HTR2A, EGFR, DPP4, ERBB2, KDR, AKT1, PDGFRB, PDGFRA, NTRK2, CSNK2A1, HTR1A, MIF, F2, TGFBR1, PTK2, VEGFA, AR, ADAM17, KIT, CDK2, FGFR1" 159 545 19453 6.06117362 8.55E-10 9.25E-11 8.43E-11 GOTERM_BP_DIRECT GO:0042327~positive regulation of phosphorylation 11 6.875 3.64E-13 "PDGFRB, CSF1R, APP, AR, FLT1, FLT3, KIT, KDR, MIF, EGFR, VEGFA" 159 38 19453 35.41592188 9.95E-10 9.25E-11 8.43E-11 GOTERM_BP_DIRECT GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway 16 10 3.72E-13 "PDGFRB, RET, PDGFRA, NTRK2, CSF1R, FLT1, SYK, FLT3, SRC, EGFR, PTK2, KIT, ERBB2, KDR, MET, FGFR1" 159 137 19453 14.28857366 1.02E-09 9.25E-11 8.43E-11 GOTERM_BP_DIRECT GO:0033674~positive regulation of kinase activity 13 8.125 5.45E-13 "PDGFRB, RET, PDGFRA, NTRK2, CSF1R, FLT1, FLT3, EGFR, KIT, ERBB2, KDR, MET, FGFR1" 159 72 19453 22.0902341 1.49E-09 1.24E-10 1.13E-10 GOTERM_BP_DIRECT GO:0043410~positive regulation of MAPK cascade 17 10.625 7.64E-13 "PDGFRB, RET, NTRK2, APP, MAP2K1, FLT1, SYK, FLT3, TGFBR1, VEGFA, P2RX7, AR, KIT, ERBB2, KDR, TLR9, FGFR1" 159 172 19453 12.09232851 2.09E-09 1.60E-10 1.46E-10 GOTERM_BP_DIRECT GO:0014068~positive regulation of phosphatidylinositol 3-kinase signaling 13 8.125 1.73E-12 "PDGFRB, PDGFRA, NTRK2, FLT1, FLT3, SRC, F2, PTK2, VEGFA, KIT, KDR, FGFR1, PPARD" 159 79 19453 20.13287159 4.73E-09 3.38E-10 3.08E-10 GOTERM_BP_DIRECT GO:0010628~positive regulation of gene expression 25 15.625 5.42E-12 "RET, APP, GSK3B, HDAC1, ERBB2, AKT1, MAPK1, NTRK2, MAP2K1, EPHX2, STAT3, BRAF, MAPK14, F3, TGFBR1, VEGFA, P2RX7, AR, CDK6, CDK1, TLR9, PPARG, PGR, TLR4, PPARD" 159 519 19453 5.89334836 1.48E-08 9.87E-10 9.00E-10 GOTERM_BP_DIRECT GO:0070374~positive regulation of ERK1 and ERK2 cascade 18 11.25 5.99E-12 "PDGFRB, PDGFRA, CSF1R, APP, MAP2K1, JUN, SRC, PLA2G2A, BRAF, PRKCA, MIF, HTR2A, OPRM1, EGFR, VEGFA, KDR, DRD2, TLR4" 159 230 19453 9.574897457 1.64E-08 1.02E-09 9.33E-10 GOTERM_BP_DIRECT GO:0030335~positive regulation of cell migration 19 11.875 6.51E-12 "PDGFRB, RET, PDGFRA, CSF1R, FLT1, HSPA5, MMP2, STAT3, PRKCA, F3, MMP9, EGFR, TGFBR1, PTK2, MYLK, VEGFA, ADAM17, KIT, KDR" 159 267 19453 8.706263397 1.78E-08 1.05E-09 9.54E-10 GOTERM_BP_DIRECT GO:0010629~negative regulation of gene expression 19 11.875 1.23E-10 "GSK3B, APP, ACE, NOS2, HDAC1, SRC, STAT3, MIF, ESR1, AURKA, VEGFA, TERT, KDR, CDK1, AKT1, PGR, PPARG, MAPT, XDH" 159 319 19453 7.287060586 3.37E-07 1.87E-08 1.71E-08 GOTERM_BP_DIRECT GO:0032496~response to lipopolysaccharide 14 8.75 2.63E-10 "ACE, MAOB, NOS2, OPRM1, PTGS2, MPO, P2RX7, ADAM17, CNR1, CYP1A1, TLR4, ELANE, IDO1, SNCA" 159 149 19453 11.49558904 7.17E-07 3.56E-08 3.24E-08 GOTERM_BP_DIRECT GO:0007165~signal transduction 36 22.5 2.66E-10 "RET, CAMK2B, CSF1R, CHRM3, GSK3B, CHRNA3, SRC, NR1I3, NR3C1, EGFR, TYMP, TTR, ANPEP, ERBB2, AKT1, MAPK1, PDGFRB, GABRA2, MAP2K1, CREBBP, CSNK2A1, DAPK1, PRKCD, STAT3, HTR3A, BRAF, MAPK14, ESR1, TGFBR1, AR, CDK6, KIT, CDK2, PPARG, PGR, MET" 159 1307 19453 3.36989505 7.28E-07 3.56E-08 3.24E-08 GOTERM_BP_DIRECT GO:0060079~excitatory postsynaptic potential 11 6.875 2.83E-10 "P2RX7, GSK3B, CHRNA3, CDK5, AKT1, HTR3A, TRPV1, OPRM1, DRD2, SLC29A1, SNCA" 159 71 19453 18.95500044 7.73E-07 3.56E-08 3.24E-08 GOTERM_BP_DIRECT GO:0043065~positive regulation of apoptotic process 19 11.875 2.86E-10 "PDGFRB, APP, JUN, ACE, DAPK1, PRKDC, SRC, MMP2, TRPV1, PTGS2, MMP9, TGFBR1, CNR1, TSPO, CYP1B1, PPARG, IDO1, MCL1, SNCA" 159 336 19453 6.918370021 7.82E-07 3.56E-08 3.24E-08 GOTERM_BP_DIRECT GO:0018107~peptidyl-threonine phosphorylation 11 6.875 3.27E-10 "GSK3B, CSNK2A1, CDK5, PRKDC, PRKCD, DYRK1A, CDK1, MAPK1, AKT1, PRKCA, TGFBR1" 159 72 19453 18.69173655 8.92E-07 3.88E-08 3.54E-08 GOTERM_BP_DIRECT GO:0042127~regulation of cell proliferation 14 8.75 1.93E-09 "PDGFRB, CSF1R, JUN, NOS2, FLT3, STAT3, PLA2G4A, BRAF, EGFR, PTK2, PTGS1, KIT, ERBB2, TSPO" 159 175 19453 9.787672956 5.27E-06 2.20E-07 2.00E-07 GOTERM_BP_DIRECT GO:0007275~multicellular organism development 13 8.125 2.23E-09 "PDGFRB, RET, PDGFRA, NTRK2, CSF1R, FLT1, FLT3, EGFR, KIT, ERBB2, KDR, MET, FGFR1" 159 144 19453 11.04511705 6.09E-06 2.43E-07 2.22E-07 GOTERM_BP_DIRECT GO:0001525~angiogenesis 16 10 2.67E-09 "PDGFRB, JUN, FLT1, SYK, MMP2, SERPINE1, PRKCA, PTGS2, MAPK14, PIK3CG, PTK2, TYMP, VEGFA, ANPEP, KDR, CYP1B1" 159 255 19453 7.67660624 7.28E-06 2.80E-07 2.55E-07 GOTERM_BP_DIRECT GO:0007568~aging 13 8.125 2.82E-09 "PDGFRB, ACE, MME, ARG1, MMP2, HTR2A, TYMS, PTGS2, MPO, CNR1, APEX1, CYP1A1, TSPO" 159 147 19453 10.8197065 7.71E-06 2.86E-07 2.60E-07 GOTERM_BP_DIRECT GO:0006805~xenobiotic metabolic process 12 7.5 3.24E-09 "ALDH3A1, BCHE, ABCC1, ABCB1, TPMT, EPHX1, CYP1A2, CYP1A1, CYP1B1, AHR, SLC29A1, ADA" 159 118 19453 12.44195715 8.85E-06 3.16E-07 2.88E-07 GOTERM_BP_DIRECT GO:0001934~positive regulation of protein phosphorylation 15 9.375 4.77E-09 "NTRK2, CSF1R, APP, BRAF, F2, MMP9, EGFR, PTK2, VEGFA, P2RX7, ADAM17, CCND1, ERBB2, KDR, AKT1" 159 226 19453 8.12030389 1.30E-05 4.49E-07 4.10E-07 GOTERM_BP_DIRECT GO:0010863~positive regulation of phospholipase C activity 6 3.75 8.09E-09 "PDGFRB, PDGFRA, FLT1, KIT, ESR1, FGFR1" 159 10 19453 73.40754717 2.21E-05 7.36E-07 6.72E-07 GOTERM_BP_DIRECT GO:1990090~cellular response to nerve growth factor stimulus 8 5 2.08E-08 "NTRK2, APP, HSPA5, PARP1, AKT1, BRAF, TRPV1, MAPT" 159 38 19453 25.75703409 5.69E-05 1.84E-06 1.67E-06 GOTERM_BP_DIRECT GO:0001666~response to hypoxia 13 8.125 2.16E-08 "CREBBP, ACE, NOS2, MMP2, VEGFA, DPP4, ADAM17, MB, CYP1A1, EP300, DRD2, PPARA, ADA" 159 176 19453 9.036913951 5.91E-05 1.85E-06 1.68E-06 GOTERM_BP_DIRECT GO:0033138~positive regulation of peptidyl-serine phosphorylation 10 6.25 6.58E-08 "NTRK2, APP, HSP90AB1, AKT1, BRAF, MIF, PTGS2, EGFR, SNCA, VEGFA" 159 93 19453 13.1554744 1.80E-04 5.44E-06 4.96E-06 GOTERM_BP_DIRECT GO:0045429~positive regulation of nitric oxide biosynthetic process 8 5 9.77E-08 "APP, HSP90AB1, AKT1, TRPV1, OPRM1, PTGS2, ESR1, TLR4" 159 47 19453 20.82483608 2.67E-04 7.85E-06 7.16E-06 GOTERM_BP_DIRECT GO:0006954~inflammatory response 18 11.25 1.01E-07 "HDAC4, CSF1R, NOS2, PLA2G2A, STAT3, TACR1, MIF, PTGS2, HDAC9, PIK3CG, PTGS1, P2RX7, IKBKB, KIT, TLR9, AKT1, TLR4, IDO1" 159 436 19453 5.050978016 2.76E-04 7.90E-06 7.20E-06 GOTERM_BP_DIRECT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 30 18.75 1.93E-07 "HDAC4, APP, THRB, PRKDC, HDAC1, NR1I3, AHR, NR3C1, HDAC8, EGFR, IKBKB, AKT1, EP300, DRD2, JUN, CREBBP, PARP1, STAT3, MAPK14, ESR1, VEGFA, AR, APEX1, TLR9, PPARG, PGR, PPARA, MET, TLR4, PPARD" 159 1232 19453 2.979202401 5.28E-04 1.47E-05 1.34E-05 GOTERM_BP_DIRECT GO:0043552~positive regulation of phosphatidylinositol 3-kinase activity 7 4.375 1.99E-07 "PDGFRB, PDGFRA, FLT1, FLT3, SRC, KIT, PTK2" 159 32 19453 26.76316824 5.42E-04 1.47E-05 1.34E-05 GOTERM_BP_DIRECT GO:0034614~cellular response to reactive oxygen species 8 5 2.30E-07 "PDGFRA, JUN, MMP2, MAPK1, AKT1, MAPT, MMP9, EGFR" 159 53 19453 18.46730746 6.28E-04 1.61E-05 1.47E-05 GOTERM_BP_DIRECT GO:0019233~sensory perception of pain 8 5 2.30E-07 "P2RX7, ACE, MME, CDK5, CNR1, TACR1, OPRM1, PTGS2" 159 53 19453 18.46730746 6.28E-04 1.61E-05 1.47E-05 GOTERM_BP_DIRECT GO:0048511~rhythmic process 9 5.625 3.09E-07 "GSK3B, CREBBP, CSNK2A1, CDK5, PRKDC, CDK1, EP300, PPARG, AHR" 159 81 19453 13.59399022 8.42E-04 2.06E-05 1.87E-05 GOTERM_BP_DIRECT GO:0009636~response to toxic substance 9 5.625 3.09E-07 "PDGFRB, MAOB, EPHX2, EPHX1, CDK1, CYP1B1, AHR, TYMS, DRD2" 159 81 19453 13.59399022 8.42E-04 2.06E-05 1.87E-05 GOTERM_BP_DIRECT "GO:0045893~positive regulation of transcription, DNA-templated" 22 13.75 4.74E-07 "KCNH2, RET, HDAC4, MAP2K1, CREBBP, JUN, HDAC1, SRC, STAT3, DYRK1A, AHR, ESR1, EGFR, TGFBR1, IKBKB, AR, CDK2, AKT1, EP300, PPARG, PPARA, PPARD" 159 728 19453 3.69726657 0.001294653 3.08E-05 2.81E-05 GOTERM_BP_DIRECT GO:1900182~positive regulation of protein localization to nucleus 7 4.375 7.97E-07 "CREBBP, PARP1, SRC, CDK1, AKT1, F2, JAK1" 159 40 19453 21.41053459 0.002175405 5.06E-05 4.62E-05 GOTERM_BP_DIRECT GO:0031401~positive regulation of protein modification process 5 3.125 8.47E-07 "PDGFRB, CSF1R, FLT1, FLT3, KIT" 159 10 19453 61.17295597 0.002310416 5.26E-05 4.80E-05 GOTERM_BP_DIRECT GO:0032757~positive regulation of interleukin-8 production 8 5 9.57E-07 "SYK, NOS2, STAT3, SERPINE1, TLR9, F3, TLR4, ELANE" 159 65 19453 15.05795839 0.002610399 5.81E-05 5.30E-05 GOTERM_BP_DIRECT GO:0030154~cell differentiation 21 13.125 1.74E-06 "CAMK2B, NTRK2, FLT1, THRB, SYK, FLT3, SRC, NR1I3, STAT3, EGFR, PTK2, TYMP, VEGFA, ANPEP, AKT1, PPARG, PPARA, JAK3, JAK1, MCL1, PPARD" 159 723 19453 3.5536157 0.004727892 1.03E-04 9.40E-05 GOTERM_BP_DIRECT GO:1902894~negative regulation of pri-miRNA transcription from RNA polymerase II promoter 6 3.75 2.32E-06 "HDAC4, APP, PPARG, PPARA, ESR1, PPARD" 159 27 19453 27.18798043 0.006310437 1.35E-04 1.23E-04 GOTERM_BP_DIRECT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 25 15.625 2.39E-06 "HDAC4, APP, THRB, HDAC1, NR1I3, NR3C1, HDAC8, HDAC9, CCND1, EP300, ELANE, SNCA, JUN, CREBBP, PARP1, STAT3, TRPV1, ESR1, VEGFA, AR, CDK6, CDK2, PPARG, PPARA, PPARD" 159 1016 19453 3.010480117 0.006500556 1.36E-04 1.24E-04 GOTERM_BP_DIRECT GO:0043536~positive regulation of blood vessel endothelial cell migration 7 4.375 2.74E-06 "ADAM17, KDR, AKT1, PRKCA, PLG, FGFR1, VEGFA" 159 49 19453 17.47798742 0.007442099 1.52E-04 1.39E-04 GOTERM_BP_DIRECT GO:0001938~positive regulation of endothelial cell proliferation 8 5 3.33E-06 "JUN, ARG1, KDR, AKT1, PRKCA, F3, TGFBR1, VEGFA" 159 78 19453 12.54829866 0.009040021 1.82E-04 1.66E-04 GOTERM_BP_DIRECT GO:1900087~positive regulation of G1/S transition of mitotic cell cycle 7 4.375 3.48E-06 "ADAM17, CCND1, TERT, APEX1, CYP1A1, AKT1, EGFR" 159 51 19453 16.79257615 0.009447541 1.86E-04 1.70E-04 GOTERM_BP_DIRECT GO:0048010~vascular endothelial growth factor receptor signaling pathway 6 3.75 4.01E-06 "FLT1, SRC, KDR, MAPK14, PTK2, VEGFA" 159 30 19453 24.46918239 0.010897184 2.07E-04 1.89E-04 GOTERM_BP_DIRECT GO:0001774~microglial cell activation 6 3.75 4.01E-06 "APP, JUN, TLR9, TRPV1, MAPT, SNCA" 159 30 19453 24.46918239 0.010897184 2.07E-04 1.89E-04 GOTERM_BP_DIRECT GO:0050729~positive regulation of inflammatory response 9 5.625 4.21E-06 "APP, ABCC1, ACE, PLA2G2A, SERPINE1, TLR9, PLA2G7, TLR4, SNCA" 159 114 19453 9.658887786 0.01143468 2.13E-04 1.94E-04 GOTERM_BP_DIRECT GO:1902895~positive regulation of pri-miRNA transcription from RNA polymerase II promoter 7 4.375 4.37E-06 "AR, JUN, TERT, STAT3, PPARG, NR3C1, EGFR" 159 53 19453 16.15889403 0.011868615 2.17E-04 1.98E-04 GOTERM_BP_DIRECT GO:0035556~intracellular signal transduction 16 10 5.68E-06 "GSK3B, SYK, DAPK1, SRC, PRKCD, BRAF, PRKCA, MAPK14, TGFBR1, KIT, ERBB2, AKT1, MAPK1, DRD2, JAK3, JAK1" 159 462 19453 4.23708786 0.015386379 2.77E-04 2.53E-04 GOTERM_BP_DIRECT GO:0048146~positive regulation of fibroblast proliferation 7 4.375 6.06E-06 "PDGFRB, PDGFRA, JUN, CDK6, MIF, ESR1, EGFR" 159 56 19453 15.29323899 0.016414324 2.90E-04 2.65E-04 GOTERM_BP_DIRECT GO:0022900~electron transport chain 7 4.375 6.73E-06 "MAOB, ALDH2, CYP1A2, GSR, AKR1B1, CYP19A1, IDO1" 159 57 19453 15.02493656 0.018206579 3.17E-04 2.89E-04 GOTERM_BP_DIRECT GO:0048661~positive regulation of smooth muscle cell proliferation 7 4.375 7.45E-06 "PDGFRB, HDAC4, HDAC1, AKT1, PTGS2, TLR4, ELANE" 159 58 19453 14.76588592 0.020152064 3.42E-04 3.12E-04 GOTERM_BP_DIRECT GO:2000379~positive regulation of reactive oxygen species metabolic process 6 3.75 7.63E-06 "PDGFRB, TSPO, CYP1B1, F2, MAPK14, XDH" 159 34 19453 21.59045505 0.020625501 3.42E-04 3.12E-04 GOTERM_BP_DIRECT GO:0030522~intracellular receptor signaling pathway 6 3.75 7.63E-06 "AR, NR1I3, STAT3, AHR, PPARA, PPARD" 159 34 19453 21.59045505 0.020625501 3.42E-04 3.12E-04 GOTERM_BP_DIRECT GO:0071320~cellular response to cAMP 7 4.375 8.24E-06 "APP, HSPA5, APEX1, CYP1B1, AHR, CFTR, PIK3CG" 159 59 19453 14.51561667 0.022260036 3.63E-04 3.31E-04 GOTERM_BP_DIRECT GO:0038084~vascular endothelial growth factor signaling pathway 5 3.125 9.18E-06 "PDGFRB, FLT1, FLT3, KDR, VEGFA" 159 17 19453 35.98409175 0.024765005 3.98E-04 3.63E-04 GOTERM_BP_DIRECT GO:0030183~B cell differentiation 8 5 9.33E-06 "HDAC4, ADAM17, SYK, FLT3, KIT, EP300, HDAC9, JAK3" 159 91 19453 10.75568457 0.025152474 3.98E-04 3.63E-04 GOTERM_BP_DIRECT GO:0071276~cellular response to cadmium ion 6 3.75 1.02E-05 "JUN, CYP1A2, MAPK1, AKT1, MMP9, EGFR" 159 36 19453 20.39098532 0.027484305 4.29E-04 3.91E-04 GOTERM_BP_DIRECT GO:0043627~response to estrogen 7 4.375 1.21E-05 "PDGFRB, CCND1, MME, MMP2, EP300, PPARG, ESR1" 159 63 19453 13.59399022 0.032510962 5.01E-04 4.57E-04 GOTERM_BP_DIRECT GO:0001890~placenta development 6 3.75 1.34E-05 "HSP90AB1, MME, PPARG, MAPK14, PTK2, ADA" 159 38 19453 19.31777557 0.03596084 5.43E-04 4.95E-04 GOTERM_BP_DIRECT GO:0007507~heart development 11 6.875 1.35E-05 "MAP2K1, MB, PRKDC, MMP2, ERBB2, EP300, PPARG, PPARA, HDAC9, TGFBR1, PPARD" 159 221 19453 6.089615527 0.036228353 5.43E-04 4.95E-04 GOTERM_BP_DIRECT GO:0042060~wound healing 8 5 1.52E-05 "PDGFRB, PDGFRA, ERBB2, OPRM1, PPARA, TGFBR1, PPARD, PLEC" 159 98 19453 9.987421384 0.040673756 6.02E-04 5.49E-04 GOTERM_BP_DIRECT GO:0048584~positive regulation of response to stimulus 4 2.5 1.80E-05 "PDGFRB, CSF1R, FLT3, KIT" 159 7 19453 69.91194969 0.047880977 6.93E-04 6.32E-04 GOTERM_BP_DIRECT GO:0045737~positive regulation of cyclin-dependent protein serine/threonine kinase activity 5 3.125 1.83E-05 "ADAM17, CCND1, SRC, AKT1, EGFR" 159 20 19453 30.58647799 0.04885476 6.93E-04 6.32E-04 GOTERM_BP_DIRECT GO:0033189~response to vitamin A 5 3.125 1.83E-05 "ARG1, CYP1A1, PPARG, TYMS, PPARD" 159 20 19453 30.58647799 0.04885476 6.93E-04 6.32E-04 GOTERM_BP_DIRECT GO:0032355~response to estradiol 8 5 1.85E-05 "PDGFRB, CCND1, STAT3, CYP1B1, TACR1, PTGS2, ESR1, CYP19A1" 159 101 19453 9.690765303 0.049328173 6.93E-04 6.32E-04 GOTERM_BP_DIRECT GO:0007611~learning or memory 7 4.375 1.89E-05 "APP, MME, SRC, EP300, MAPK1, MAPT, EGFR" 159 68 19453 12.59443211 0.050189653 6.96E-04 6.35E-04 GOTERM_BP_DIRECT GO:0035094~response to nicotine 6 3.75 1.96E-05 "CHRNA3, CNR1, MMP2, MAPK1, TACR1, DRD2" 159 41 19453 17.9042798 0.052203783 7.15E-04 6.52E-04 GOTERM_BP_DIRECT GO:0007623~circadian rhythm 7 4.375 2.42E-05 "NTRK2, GSK3B, NOS2, DYRK1A, EP300, TOP1, TYMS" 159 71 19453 12.06227301 0.063908276 8.69E-04 7.93E-04 GOTERM_BP_DIRECT GO:0042307~positive regulation of protein import into nucleus 6 3.75 2.49E-05 "HSP90AB1, PRKCD, CDK1, EP300, MAPK14, PTGS2" 159 43 19453 17.0715226 0.065715435 8.83E-04 8.05E-04 GOTERM_BP_DIRECT GO:0008285~negative regulation of cell proliferation 15 9.375 2.54E-05 "HDAC4, BCHE, CSF1R, APP, MAP2K1, JUN, STAT3, PLG, OPRM1, SSTR2, PTGS2, AR, CDK6, CYP1B1, DRD2" 159 462 19453 3.972269868 0.066955402 8.88E-04 8.10E-04 GOTERM_BP_DIRECT GO:0050728~negative regulation of inflammatory response 9 5.625 3.00E-05 "ALOX5, STAT3, PRKCD, PPARG, AHR, PPARA, ADA, ELANE, PPARD" 159 149 19453 7.390021527 0.078583321 0.001035971 9.45E-04 GOTERM_BP_DIRECT GO:0032092~positive regulation of protein binding 7 4.375 3.07E-05 "GSK3B, APP, ACE, HSP90AB1, TERT, CDK5, EP300" 159 74 19453 11.57326194 0.080320474 0.001046609 9.55E-04 GOTERM_BP_DIRECT GO:0014911~positive regulation of smooth muscle cell migration 5 3.125 3.29E-05 "PDGFRB, HDAC4, SRC, CYP1B1, TLR4" 159 23 19453 26.59693738 0.085907225 0.00110891 0.001011459 GOTERM_BP_DIRECT GO:1904646~cellular response to beta-amyloid 6 3.75 3.48E-05 "GSK3B, APP, ABCC1, CDK5, PARP1, TLR4" 159 46 19453 15.95816243 0.090551083 0.001157498 0.001055777 GOTERM_BP_DIRECT GO:0071222~cellular response to lipopolysaccharide 10 6.25 3.56E-05 "NOS2, SRC, ARG1, SERPINE1, TLR9, TSPO, MAPK14, TLR4, MMP9, PPARD" 159 198 19453 6.179086462 0.092529409 0.001169788 0.001066987 GOTERM_BP_DIRECT GO:0008584~male gonad development 8 5 3.62E-05 "PDGFRB, AR, ACE, KIT, TLR9, CYP1B1, ESR1, TGFBR1" 159 112 19453 8.738993711 0.094171731 0.001177426 0.001073954 GOTERM_BP_DIRECT GO:0007204~positive regulation of cytosolic calcium ion concentration 9 5.625 3.97E-05 "PDGFRA, APP, TRPV1, TACR1, HTR2A, OPRM1, ESR1, JAK3, PIK3CG" 159 155 19453 7.103956178 0.102864353 0.001277012 0.001164789 GOTERM_BP_DIRECT GO:0051901~positive regulation of mitochondrial depolarization 4 2.5 4.26E-05 "P2RX7, PARP1, KDR, TSPO" 159 9 19453 54.37596087 0.109842467 0.001352958 0.00123406 GOTERM_BP_DIRECT GO:0007399~nervous system development 14 8.75 4.53E-05 "CAMK2B, HDAC4, ACHE, CHRM3, NTRK2, APP, CHRNA3, SIGMAR1, STAT3, DYRK1A, TGFBR1, VEGFA, EP300, MET" 159 425 19453 4.030218276 0.116369647 0.001421996 0.001297031 GOTERM_BP_DIRECT GO:0043491~protein kinase B signaling 7 4.375 5.13E-05 "ERBB2, STAT3, KDR, AKT1, HTR2A, DRD2, PIK3CG" 159 81 19453 10.5731035 0.130636293 0.001590797 0.001450998 GOTERM_BP_DIRECT GO:0008542~visual learning 6 3.75 5.23E-05 "APP, CDK5, KIT, BRAF, HMGCR, DRD2" 159 50 19453 14.68150943 0.133182745 0.00160588 0.001464756 GOTERM_BP_DIRECT GO:0007173~epidermal growth factor receptor signaling pathway 6 3.75 5.76E-05 "ADAM17, SRC, AKT1, BRAF, PTK2, EGFR" 159 51 19453 14.3936367 0.145664463 0.001749186 0.001595468 GOTERM_BP_DIRECT GO:0070933~histone H4 deacetylation 4 2.5 6.05E-05 "HDAC4, HDAC1, HDAC8, HDAC9" 159 10 19453 48.93836478 0.152304828 0.001815705 0.001656141 GOTERM_BP_DIRECT GO:0032094~response to food 5 3.125 6.36E-05 "CYP1A1, AKT1, OPRM1, MPO, PLEC" 159 27 19453 22.65665036 0.159348905 0.001886664 0.001720864 GOTERM_BP_DIRECT GO:0045766~positive regulation of angiogenesis 9 5.625 6.46E-05 "FLT1, TERT, STAT3, SERPINE1, KDR, CYP1B1, PRKCA, F3, VEGFA" 159 166 19453 6.633212094 0.161800626 0.001897781 0.001731004 GOTERM_BP_DIRECT GO:2001243~negative regulation of intrinsic apoptotic signaling pathway 5 3.125 7.37E-05 "HDAC1, SRC, AKT1, MMP9, MCL1" 159 28 19453 21.84748428 0.182278344 0.002140701 0.001952576 GOTERM_BP_DIRECT GO:0070371~ERK1 and ERK2 cascade 6 3.75 7.61E-05 "MAP2K1, CDK1, KDR, MAPK1, BRAF, TLR4" 159 54 19453 13.59399022 0.187661069 0.002187681 0.001995428 GOTERM_BP_DIRECT GO:0071492~cellular response to UV-A 4 2.5 8.27E-05 "MME, MMP1, MMP2, MMP9" 159 11 19453 44.48942253 0.20215825 0.002352455 0.002145721 GOTERM_BP_DIRECT GO:0043154~negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 6 3.75 9.07E-05 "CSNK2A1, SRC, AKT1, PTGS2, SNCA, VEGFA" 159 56 19453 13.10849057 0.219469024 0.002554326 0.002329852 GOTERM_BP_DIRECT GO:0030182~neuron differentiation 9 5.625 9.39E-05 "NTRK2, MAP2K1, CCND1, CDK5, HSPA5, HDAC1, ERBB2, HDAC9, MET" 159 175 19453 6.292075472 0.226261361 0.00261744 0.002387419 GOTERM_BP_DIRECT GO:0030307~positive regulation of cell growth 7 4.375 1.05E-04 "ADAM17, CSNK2A1, ERBB2, AKT1, F2, EGFR, TGFBR1" 159 92 19453 9.308928083 0.248624519 0.002875101 0.002622437 GOTERM_BP_DIRECT GO:0008283~cell proliferation 9 5.625 1.05E-04 "CSF1R, SRC, STAT3, ODC1, CYP1A1, CDK1, AKT1, TYR, PPARD" 159 178 19453 6.186029256 0.249882325 0.002875101 0.002622437 GOTERM_BP_DIRECT GO:1901215~negative regulation of neuron death 6 3.75 1.07E-04 "GSK3B, APP, CDK5, AKT1, PPARA, SNCA" 159 58 19453 12.65647365 0.254259375 0.002904571 0.002649318 GOTERM_BP_DIRECT GO:0030518~intracellular steroid hormone receptor signaling pathway 4 2.5 1.42E-04 "AR, PGR, NR3C1, ESR1" 159 13 19453 37.64489598 0.320790001 0.003792133 0.00345888 GOTERM_BP_DIRECT GO:0035924~cellular response to vascular endothelial growth factor stimulus 5 3.125 1.61E-04 "FLT1, KDR, AKT1, MAPK14, VEGFA" 159 34 19453 17.99204587 0.355231405 0.004260229 0.00388584 GOTERM_BP_DIRECT GO:0006915~apoptotic process 16 10 1.62E-04 "APP, PARP1, CSNK2A1, DAPK1, PRKCD, AHR, MAPK14, NR3C1, MMP9, TGFBR1, AURKA, CDK1, EP300, MAPK1, MCL1, PPARD" 159 619 19453 3.162414525 0.357956832 0.004260229 0.00388584 GOTERM_BP_DIRECT GO:0071498~cellular response to fluid shear stress 4 2.5 1.79E-04 "SRC, MMP2, PTGS2, PLEC" 159 14 19453 34.95597484 0.387005884 0.004660534 0.004250967 GOTERM_BP_DIRECT "GO:0007187~G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" 6 3.75 1.85E-04 "CHRM3, CNR1, HTR1A, HTR2A, OPRM1, SSTR2" 159 65 19453 11.2934688 0.396659822 0.004766296 0.004347434 GOTERM_BP_DIRECT GO:0006157~deoxyadenosine catabolic process 3 1.875 1.96E-04 "PNP, XDH, ADA" 159 3 19453 122.3459119 0.413904627 0.004901105 0.004470397 GOTERM_BP_DIRECT GO:0038091~positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway 3 1.875 1.96E-04 "PDGFRB, PDGFRA, VEGFA" 159 3 19453 122.3459119 0.413904627 0.004901105 0.004470397 GOTERM_BP_DIRECT GO:0070141~response to UV-A 3 1.875 1.96E-04 "CCND1, AKT1, EGFR" 159 3 19453 122.3459119 0.413904627 0.004901105 0.004470397 GOTERM_BP_DIRECT GO:0045087~innate immune response 16 10 2.10E-04 "CSF1R, APP, SYK, PARP1, DAPK1, PRKDC, SRC, ARG1, MIF, PIK3CG, PTK2, IKBKB, TLR9, PPARG, JAK3, TLR4" 159 634 19453 3.087593992 0.436681249 0.005216812 0.004758359 GOTERM_BP_DIRECT GO:0032755~positive regulation of interleukin-6 production 7 4.375 2.17E-04 "P2RX7, APP, SYK, NOS2, STAT3, TLR9, TLR4" 159 105 19453 8.15639413 0.446611009 0.00533 0.0048616 GOTERM_BP_DIRECT GO:0042220~response to cocaine 5 3.125 2.25E-04 "HSP90AB1, HSPA5, CNR1, OPRM1, DRD2" 159 37 19453 16.53323134 0.458436887 0.005426786 0.004949881 GOTERM_BP_DIRECT GO:1901216~positive regulation of neuron death 5 3.125 2.25E-04 "GSK3B, APP, PARP1, MAPT, SNCA" 159 37 19453 16.53323134 0.458436887 0.005426786 0.004949881 GOTERM_BP_DIRECT GO:0070301~cellular response to hydrogen peroxide 6 3.75 2.45E-04 "SRC, ARG1, APEX1, PRKCD, CDK1, CYP1B1" 159 69 19453 10.63877495 0.488198181 0.005874874 0.005358591 GOTERM_BP_DIRECT GO:0070555~response to interleukin-1 5 3.125 2.49E-04 "HDAC4, APP, SRC, PRKCA, SNCA" 159 38 19453 16.09814631 0.493964004 0.005922283 0.005401833 GOTERM_BP_DIRECT GO:0070932~histone H3 deacetylation 4 2.5 2.72E-04 "HDAC4, HDAC1, HDAC8, HDAC9" 159 16 19453 30.58647799 0.524801031 0.006413106 0.005849523 GOTERM_BP_DIRECT GO:0033077~T cell differentiation in thymus 5 3.125 3.05E-04 "ADAM17, CDK6, PRKDC, BRAF, ADA" 159 40 19453 15.29323899 0.565162332 0.007116714 0.006491298 GOTERM_BP_DIRECT GO:0045471~response to ethanol 7 4.375 3.22E-04 "MAOB, CCND1, CNR1, CDK1, TACR1, TYMS, PPARA" 159 113 19453 7.578950298 0.585569638 0.00746363 0.006807727 GOTERM_BP_DIRECT GO:0048169~regulation of long-term neuronal synaptic plasticity 4 2.5 3.29E-04 "CAMK2B, APP, DRD2, SNCA" 159 17 19453 28.7872734 0.592659536 0.007482986 0.006825382 GOTERM_BP_DIRECT GO:0048266~behavioral response to pain 4 2.5 3.29E-04 "TSPO, AKT1, TRPV1, TACR1" 159 17 19453 28.7872734 0.592659536 0.007482986 0.006825382 GOTERM_BP_DIRECT GO:0071902~positive regulation of protein serine/threonine kinase activity 5 3.125 3.36E-04 "CSF1R, MAP2K1, HSP90AB1, SRC, SNCA" 159 41 19453 14.92023316 0.600295619 0.007516871 0.00685629 GOTERM_BP_DIRECT GO:0019221~cytokine-mediated signaling pathway 8 5 3.36E-04 "CSF1R, FLT3, STAT3, KIT, AKT1, JAK3, F3, JAK1" 159 160 19453 6.117295597 0.600368468 0.007516871 0.00685629 GOTERM_BP_DIRECT GO:0032091~negative regulation of protein binding 6 3.75 3.62E-04 "GSK3B, ACE, PRKCD, AKT1, PPARA, AURKA" 159 75 19453 9.787672956 0.628169506 0.008041773 0.007335062 GOTERM_BP_DIRECT GO:0006508~proteolysis 13 8.125 3.73E-04 "ACE, MME, MMP1, MMP2, PLG, F2, F3, MMP9, DPP4, ADAM17, ANPEP, ELANE, CTSB" 159 458 19453 3.472700558 0.638721864 0.008209011 0.007487604 GOTERM_BP_DIRECT GO:0043524~negative regulation of neuron apoptotic process 8 5 3.77E-04 "NTRK2, JUN, HSP90AB1, CCND1, TERT, KDR, BRAF, SNCA" 159 163 19453 6.004707335 0.643016763 0.008238978 0.007514937 GOTERM_BP_DIRECT GO:0046059~dAMP catabolic process 3 1.875 3.89E-04 "PNP, XDH, ADA" 159 4 19453 91.75943396 0.654560834 0.0083683 0.007632894 GOTERM_BP_DIRECT GO:0051770~positive regulation of nitric-oxide synthase biosynthetic process 4 2.5 3.92E-04 "TLR9, KDR, JAK3, TLR4" 159 18 19453 27.18798043 0.657455076 0.0083683 0.007632894 GOTERM_BP_DIRECT GO:0060749~mammary gland alveolus development 4 2.5 3.92E-04 "AR, CCND1, ESR1, VEGFA" 159 18 19453 27.18798043 0.657455076 0.0083683 0.007632894 GOTERM_BP_DIRECT GO:0051091~positive regulation of sequence-specific DNA binding transcription factor activity 7 4.375 4.07E-04 "HDAC4, APP, KIT, EP300, AKT1, PPARG, ESR1" 159 118 19453 7.257808336 0.670876018 0.008613137 0.007856215 GOTERM_BP_DIRECT GO:0006338~chromatin remodeling 11 6.875 4.33E-04 "HDAC4, CREBBP, HDAC1, CDK2, DYRK1A, CDK1, PRKCA, TOP1, HDAC8, ESR1, AURKA" 159 336 19453 4.005372117 0.693408976 0.00909219 0.00829317 GOTERM_BP_DIRECT GO:0016477~cell migration 10 6.25 4.59E-04 "PDGFRB, FLT1, MMP2, CDK1, KDR, MET, MMP9, PTK2, PIK3CG, FGFR1" 159 278 19453 4.400932085 0.714609337 0.009506922 0.008671454 GOTERM_BP_DIRECT GO:2000811~negative regulation of anoikis 4 2.5 4.63E-04 "NTRK2, SRC, PTK2, MCL1" 159 19 19453 25.75703409 0.717679802 0.009506922 0.008671454 GOTERM_BP_DIRECT GO:0030224~monocyte differentiation 4 2.5 4.63E-04 "CSF1R, JUN, PPARG, VEGFA" 159 19 19453 25.75703409 0.717679802 0.009506922 0.008671454 GOTERM_BP_DIRECT GO:0032735~positive regulation of interleukin-12 production 5 3.125 4.82E-04 "SYK, TLR9, MAPK14, TLR4, IDO1" 159 45 19453 13.59399022 0.731720437 0.009743769 0.008887488 GOTERM_BP_DIRECT GO:0032722~positive regulation of chemokine production 5 3.125 4.82E-04 "CSF1R, APP, ADAM17, TLR9, TLR4" 159 45 19453 13.59399022 0.731720437 0.009743769 0.008887488 GOTERM_BP_DIRECT GO:0022617~extracellular matrix disassembly 5 3.125 5.24E-04 "MMP1, MMP2, PLG, MMP9, ELANE" 159 46 19453 13.29846869 0.761174402 0.010449973 0.009531631 GOTERM_BP_DIRECT GO:0002223~stimulatory C-type lectin receptor signaling pathway 5 3.125 5.24E-04 "IKBKB, CREBBP, SYK, SRC, EP300" 159 46 19453 13.29846869 0.761174402 0.010449973 0.009531631 GOTERM_BP_DIRECT GO:0001516~prostaglandin biosynthetic process 4 2.5 5.41E-04 "PLA2G4A, MIF, PTGS2, PTGS1" 159 20 19453 24.46918239 0.772160775 0.010487337 0.009565711 GOTERM_BP_DIRECT GO:0032930~positive regulation of superoxide anion generation 4 2.5 5.41E-04 "APP, SYK, PRKCD, MAPT" 159 20 19453 24.46918239 0.772160775 0.010487337 0.009565711 GOTERM_BP_DIRECT GO:1900034~regulation of cellular response to heat 4 2.5 5.41E-04 "GSK3B, CREBBP, EP300, MAPT" 159 20 19453 24.46918239 0.772160775 0.010487337 0.009565711 GOTERM_BP_DIRECT GO:2000573~positive regulation of DNA biosynthetic process 4 2.5 5.41E-04 "PDGFRB, SRC, CYP1B1, VEGFA" 159 20 19453 24.46918239 0.772160775 0.010487337 0.009565711 GOTERM_BP_DIRECT GO:0006919~activation of cysteine-type endopeptidase activity involved in apoptotic process 6 3.75 5.47E-04 "RET, PPARG, MAPT, F3, XDH, SNCA" 159 82 19453 8.952139899 0.77565077 0.01052213 0.009597447 GOTERM_BP_DIRECT GO:0050673~epithelial cell proliferation 5 3.125 5.69E-04 "AR, KIT, KDR, DRD2, EGFR" 159 47 19453 13.01552255 0.788905545 0.010798658 0.009849673 GOTERM_BP_DIRECT GO:0048015~phosphatidylinositol-mediated signaling 5 3.125 5.69E-04 "PDGFRB, PDGFRA, CSF1R, PIK3CG, FGFR1" 159 47 19453 13.01552255 0.788905545 0.010798658 0.009849673 GOTERM_BP_DIRECT GO:0030324~lung development 6 3.75 5.78E-04 "PDGFRA, MME, ARG1, CYP1A2, EP300, VEGFA" 159 83 19453 8.844282792 0.794041283 0.010893948 0.009936589 GOTERM_BP_DIRECT GO:0048538~thymus development 5 3.125 6.17E-04 "MAP2K1, MAPK1, BRAF, TYR, TGFBR1" 159 48 19453 12.74436583 0.814787753 0.011546112 0.010531441 GOTERM_BP_DIRECT GO:0038096~Fc-gamma receptor signaling pathway involved in phagocytosis 4 2.5 6.28E-04 "SYK, SRC, PRKCD, PTK2" 159 21 19453 23.30398323 0.820118777 0.011666121 0.010640904 GOTERM_BP_DIRECT GO:0032310~prostaglandin secretion 3 1.875 6.45E-04 "P2RX7, NOS2, PTGS2" 159 5 19453 73.40754717 0.82835554 0.011823903 0.01078482 GOTERM_BP_DIRECT GO:0045923~positive regulation of fatty acid metabolic process 3 1.875 6.45E-04 "PPARG, PPARA, PPARD" 159 5 19453 73.40754717 0.82835554 0.011823903 0.01078482 GOTERM_BP_DIRECT GO:0016079~synaptic vesicle exocytosis 4 2.5 7.23E-04 "P2RX7, CDK5, BRAF, SNCA" 159 22 19453 22.24471126 0.861185963 0.012986226 0.011844998 GOTERM_BP_DIRECT GO:0050850~positive regulation of calcium-mediated signaling 4 2.5 7.23E-04 "PDGFRB, PDGFRA, SYK, ADA" 159 22 19453 22.24471126 0.861185963 0.012986226 0.011844998 GOTERM_BP_DIRECT GO:0038083~peptidyl-tyrosine autophosphorylation 4 2.5 7.23E-04 "SRC, DYRK1A, KDR, EGFR" 159 22 19453 22.24471126 0.861185963 0.012986226 0.011844998 GOTERM_BP_DIRECT GO:0071456~cellular response to hypoxia 7 4.375 7.97E-04 "TERT, SRC, PPARG, SLC29A1, PTGS2, PPARD, VEGFA" 159 134 19453 6.391204356 0.886670532 0.014226067 0.012975882 GOTERM_BP_DIRECT GO:0006809~nitric oxide biosynthetic process 4 2.5 8.26E-04 "NOS2, CYP1B1, AKT1, TLR4" 159 23 19453 21.2775499 0.895383277 0.014558188 0.013278816 GOTERM_BP_DIRECT GO:0080090~regulation of primary metabolic process 4 2.5 8.26E-04 "PRKCD, TLR9, PRKCA, TGFBR1" 159 23 19453 21.2775499 0.895383277 0.014558188 0.013278816 GOTERM_BP_DIRECT GO:0031648~protein destabilization 5 3.125 8.37E-04 "CREBBP, PRKDC, SRC, EP300, SNCA" 159 52 19453 11.76403 0.898542847 0.014661285 0.013372853 GOTERM_BP_DIRECT GO:0042981~regulation of apoptotic process 9 5.625 8.98E-04 "CDK5, FLT3, DAPK1, APEX1, AKT1, ESR1, JAK3, CTSB, MCL1" 159 245 19453 4.494339623 0.914076643 0.015625459 0.014252295 GOTERM_BP_DIRECT GO:1990962~drug transport across blood-brain barrier 3 1.875 9.62E-04 "ABCC1, ABCB1, ABCG2" 159 6 19453 61.17295597 0.927907508 0.016636327 0.015174328 GOTERM_BP_DIRECT GO:0071356~cellular response to tumor necrosis factor 7 4.375 0.001001415 "HDAC4, IKBKB, CYP1B1, MAPK1, AKT1, TRPV1, MAPK14" 159 140 19453 6.117295597 0.935186063 0.017200405 0.015688835 GOTERM_BP_DIRECT GO:1904707~positive regulation of vascular smooth muscle cell proliferation 5 3.125 0.001035348 "JUN, TERT, SRC, MMP2, MMP9" 159 55 19453 11.12235563 0.940928145 0.017562335 0.016018959 GOTERM_BP_DIRECT GO:0042572~retinol metabolic process 5 3.125 0.001035348 "TTR, CYP1A2, CYP1A1, AKR1B1, CYP1B1" 159 55 19453 11.12235563 0.940928145 0.017562335 0.016018959 GOTERM_BP_DIRECT GO:0036120~cellular response to platelet-derived growth factor stimulus 4 2.5 0.001060373 "PDGFRB, HDAC1, SRC, TLR4" 159 25 19453 19.57534591 0.944834396 0.01776613 0.016204844 GOTERM_BP_DIRECT GO:0046686~response to cadmium ion 4 2.5 0.001060373 "TERT, ARG1, KIT, CDK1" 159 25 19453 19.57534591 0.944834396 0.01776613 0.016204844 GOTERM_BP_DIRECT GO:0090398~cellular senescence 5 3.125 0.001184178 "MAP2K1, CDK2, PRKCD, MIF, MAPK14" 159 57 19453 10.73209754 0.960675492 0.019486194 0.017773749 GOTERM_BP_DIRECT GO:0043393~regulation of protein binding 4 2.5 0.001191576 "HDAC4, APP, SRC, TGFBR1" 159 26 19453 18.82244799 0.961462932 0.019486194 0.017773749 GOTERM_BP_DIRECT GO:0046697~decidualization 4 2.5 0.001191576 "PARP1, PTGS2, CTSB, PPARD" 159 26 19453 18.82244799 0.961462932 0.019486194 0.017773749 GOTERM_BP_DIRECT GO:0030325~adrenal gland development 4 2.5 0.001191576 "PDGFRA, TSPO, CYP1B1, NR3C1" 159 26 19453 18.82244799 0.961462932 0.019486194 0.017773749 GOTERM_BP_DIRECT GO:0007268~chemical synaptic transmission 9 5.625 0.001218696 "GABRA2, CHRM3, CHRNA3, CDK5, HTR1A, MAPK1, HTR3A, HTR2A, SNCA" 159 257 19453 4.284487189 0.964217186 0.019811059 0.018070065 GOTERM_BP_DIRECT GO:0000086~G2/M transition of mitotic cell cycle 5 3.125 0.001263938 "APP, ABCB1, CDK2, CDK1, AURKA" 159 58 19453 10.54706137 0.968381051 0.020424943 0.018630001 GOTERM_BP_DIRECT GO:0006631~fatty acid metabolic process 6 3.75 0.001284329 "FABP2, CYP1A1, PPARG, PPARA, PPARD, SNCA" 159 99 19453 7.414903755 0.970095838 0.020632372 0.018819201 GOTERM_BP_DIRECT GO:0050482~arachidonic acid secretion 4 2.5 0.001332579 "ACE, PLA2G2A, PLA2G4A, DRD2" 159 27 19453 18.12532029 0.97379222 0.02078925 0.018962293 GOTERM_BP_DIRECT GO:0038113~interleukin-9-mediated signaling pathway 3 1.875 0.001340289 "STAT3, JAK3, JAK1" 159 7 19453 52.43396226 0.974339044 0.02078925 0.018962293 GOTERM_BP_DIRECT GO:0002318~myeloid progenitor cell differentiation 3 1.875 0.001340289 "FLT3, KIT, BRAF" 159 7 19453 52.43396226 0.974339044 0.02078925 0.018962293 GOTERM_BP_DIRECT GO:0046321~positive regulation of fatty acid oxidation 3 1.875 0.001340289 "PPARG, PPARA, PPARD" 159 7 19453 52.43396226 0.974339044 0.02078925 0.018962293 GOTERM_BP_DIRECT GO:0014047~glutamate secretion 3 1.875 0.001340289 "P2RX7, NTRK2, TRPV1" 159 7 19453 52.43396226 0.974339044 0.02078925 0.018962293 GOTERM_BP_DIRECT GO:0007210~serotonin receptor signaling pathway 3 1.875 0.001340289 "HTR1A, HTR3A, HTR2A" 159 7 19453 52.43396226 0.974339044 0.02078925 0.018962293 GOTERM_BP_DIRECT GO:0009612~response to mechanical stimulus 5 3.125 0.001347381 "P2RX7, SRC, MMP2, PPARG, MPO" 159 59 19453 10.36829762 0.974831912 0.02078925 0.018962293 GOTERM_BP_DIRECT GO:0007166~cell surface receptor signaling pathway 10 6.25 0.00150494 "P2RX7, CDA, ERBB2, MAPK1, TRPV1, MIF, F2, MAPK14, MET, EGFR" 159 329 19453 3.718720728 0.983642805 0.023089841 0.021060708 GOTERM_BP_DIRECT GO:0034644~cellular response to UV 5 3.125 0.001525672 "CREBBP, PARP1, PRKCD, EP300, PTGS2" 159 61 19453 10.02835344 0.984544503 0.023111762 0.021080703 GOTERM_BP_DIRECT GO:0046718~viral entry into host cell 6 3.75 0.001531757 "DPP4, ANPEP, CDK1, HTR2A, EGFR, CTSB" 159 103 19453 7.126946327 0.984799638 0.023111762 0.021080703 GOTERM_BP_DIRECT GO:0007179~transforming growth factor beta receptor signaling pathway 6 3.75 0.001531757 "JUN, PARP1, SRC, STAT3, PTK2, TGFBR1" 159 103 19453 7.126946327 0.984799638 0.023111762 0.021080703 GOTERM_BP_DIRECT GO:0043525~positive regulation of neuron apoptotic process 5 3.125 0.001620698 "HDAC4, APP, CDK5, HTR2A, NR3C1" 159 62 19453 9.866605802 0.988082121 0.024319368 0.022182185 GOTERM_BP_DIRECT GO:0010507~negative regulation of autophagy 5 3.125 0.001719762 "STAT3, EP300, AKT1, MET, MCL1" 159 63 19453 9.709993012 0.990911217 0.025664869 0.023409443 GOTERM_BP_DIRECT GO:0032869~cellular response to insulin stimulus 6 3.75 0.001739112 "PARP1, PRKDC, SRC, AKT1, PPARG, HDAC9" 159 106 19453 6.925240299 0.991379834 0.025684802 0.023427625 GOTERM_BP_DIRECT GO:2000641~regulation of early endosome to late endosome transport 3 1.875 0.001777528 "MAP2K1, SRC, MAPK1" 159 8 19453 45.87971698 0.9922398 0.025684802 0.023427625 GOTERM_BP_DIRECT GO:0038110~interleukin-2-mediated signaling pathway 3 1.875 0.001777528 "STAT3, JAK3, JAK1" 159 8 19453 45.87971698 0.9922398 0.025684802 0.023427625 GOTERM_BP_DIRECT GO:0000255~allantoin metabolic process 3 1.875 0.001777528 "PNP, XDH, ADA" 159 8 19453 45.87971698 0.9922398 0.025684802 0.023427625 GOTERM_BP_DIRECT GO:0034405~response to fluid shear stress 3 1.875 0.001777528 "P2RX7, PDGFRB, AKT1" 159 8 19453 45.87971698 0.9922398 0.025684802 0.023427625 GOTERM_BP_DIRECT GO:0042135~neurotransmitter catabolic process 3 1.875 0.001777528 "MAOB, MAOA, COMT" 159 8 19453 45.87971698 0.9922398 0.025684802 0.023427625 GOTERM_BP_DIRECT GO:0000165~MAPK cascade 7 4.375 0.001801175 "P2RX7, RET, AR, MAP2K1, BRAF, EGFR, FGFR1" 159 157 19453 5.454913272 0.992725972 0.025889525 0.023614356 GOTERM_BP_DIRECT GO:0042755~eating behavior 4 2.5 0.001816998 "ACE, STAT3, TACR1, OPRM1" 159 30 19453 16.31278826 0.99303414 0.025980213 0.023697074 GOTERM_BP_DIRECT GO:0032760~positive regulation of tumor necrosis factor production 6 3.75 0.001888328 "APP, SYK, STAT3, TLR9, MIF, TLR4" 159 108 19453 6.796995108 0.9942692 0.026859504 0.024499094 GOTERM_BP_DIRECT GO:0006006~glucose metabolic process 5 3.125 0.001930361 "GAA, AKT1, MAPK14, GAPDH, PPARD" 159 65 19453 9.411223996 0.994891818 0.027315113 0.024914664 GOTERM_BP_DIRECT GO:0048009~insulin-like growth factor receptor signaling pathway 4 2.5 0.001999772 "AR, MAP2K1, MAPK1, AKT1" 159 31 19453 15.78656928 0.995775461 0.027864168 0.025415468 GOTERM_BP_DIRECT GO:0070372~regulation of ERK1 and ERK2 cascade 4 2.5 0.001999772 "SYK, ERBB2, HMGCR, EGFR" 159 31 19453 15.78656928 0.995775461 0.027864168 0.025415468 GOTERM_BP_DIRECT GO:0045776~negative regulation of blood pressure 4 2.5 0.001999772 "NOS2, CNR1, DRD2, PPARA" 159 31 19453 15.78656928 0.995775461 0.027864168 0.025415468 GOTERM_BP_DIRECT GO:0060291~long-term synaptic potentiation 5 3.125 0.002042071 "NTRK2, MAPK1, BRAF, HMGCR, SNCA" 159 66 19453 9.268629693 0.996237223 0.028024603 0.025561804 GOTERM_BP_DIRECT GO:0014070~response to organic cyclic compound 5 3.125 0.002042071 "SLC22A6, EPHX1, CYP1A1, CDK1, PPARA" 159 66 19453 9.268629693 0.996237223 0.028024603 0.025561804 GOTERM_BP_DIRECT GO:0042752~regulation of circadian rhythm 5 3.125 0.002042071 "GSK3B, PRKDC, CDK1, PPARG, PPARA" 159 66 19453 9.268629693 0.996237223 0.028024603 0.025561804 GOTERM_BP_DIRECT GO:0051602~response to electrical stimulus 4 2.5 0.002193592 "P2RX7, SRC, MMP2, TACR1" 159 32 19453 15.29323899 0.997514496 0.029656929 0.027050681 GOTERM_BP_DIRECT GO:0030225~macrophage differentiation 4 2.5 0.002193592 "CSF1R, PARP1, MMP9, VEGFA" 159 32 19453 15.29323899 0.997514496 0.029656929 0.027050681 GOTERM_BP_DIRECT GO:0045907~positive regulation of vasoconstriction 4 2.5 0.002193592 "ACE, TACR1, HTR2A, PTGS2" 159 32 19453 15.29323899 0.997514496 0.029656929 0.027050681 GOTERM_BP_DIRECT GO:0051092~positive regulation of NF-kappaB transcription factor activity 7 4.375 0.002238091 "IKBKB, APP, AR, STAT3, TLR9, EP300, TLR4" 159 164 19453 5.222081608 0.997799515 0.030109494 0.027463475 GOTERM_BP_DIRECT GO:0010595~positive regulation of endothelial cell migration 5 3.125 0.002278747 "KDR, AKT1, PRKCA, PIK3CG, VEGFA" 159 68 19453 8.996022937 0.998031256 0.030506166 0.027825287 GOTERM_BP_DIRECT GO:0008210~estrogen metabolic process 4 2.5 0.002398683 "PDGFRA, CYP1A2, CYP1A1, CYP1B1" 159 33 19453 14.82980751 0.998582235 0.031868996 0.029068352 GOTERM_BP_DIRECT GO:0030168~platelet activation 5 3.125 0.002403886 "SYK, SRC, PRKCA, F2, MAPK14" 159 69 19453 8.865645793 0.998602285 0.031868996 0.029068352 GOTERM_BP_DIRECT GO:0071897~DNA biosynthetic process 4 2.5 0.002615264 "TERT, SRC, TK1, TYMS" 159 34 19453 14.3936367 0.999216423 0.034173616 0.031170442 GOTERM_BP_DIRECT GO:0030511~positive regulation of transforming growth factor beta receptor signaling pathway 4 2.5 0.002615264 "ADAM17, CREBBP, HSP90AB1, EP300" 159 34 19453 14.3936367 0.999216423 0.034173616 0.031170442 GOTERM_BP_DIRECT GO:0045824~negative regulation of innate immune response 4 2.5 0.002615264 "PARP1, PRKDC, AKT1, DRD2" 159 34 19453 14.3936367 0.999216423 0.034173616 0.031170442 GOTERM_BP_DIRECT GO:0032922~circadian regulation of gene expression 5 3.125 0.002668196 "HDAC1, AHR, TOP1, DRD2, PPARA" 159 71 19453 8.615909292 0.999322149 0.034699256 0.031649889 GOTERM_BP_DIRECT GO:1901224~positive regulation of NIK/NF-kappaB signaling 5 3.125 0.002807537 "APP, TLR9, EP300, TLR4, EGFR" 159 72 19453 8.496243885 0.999537178 0.035570951 0.032444979 GOTERM_BP_DIRECT GO:0046638~positive regulation of alpha-beta T cell differentiation 3 1.875 0.002826399 "PNP, SYK, ADA" 159 10 19453 36.70377358 0.999560479 0.035570951 0.032444979 GOTERM_BP_DIRECT GO:0051272~positive regulation of cellular component movement 3 1.875 0.002826399 "ADAM17, TGFBR1, VEGFA" 159 10 19453 36.70377358 0.999560479 0.035570951 0.032444979 GOTERM_BP_DIRECT GO:0002070~epithelial cell maturation 3 1.875 0.002826399 "KDR, AKR1B1, PGR" 159 10 19453 36.70377358 0.999560479 0.035570951 0.032444979 GOTERM_BP_DIRECT GO:0070633~transepithelial transport 3 1.875 0.002826399 "ABCC1, ABCB1, ABCG2" 159 10 19453 36.70377358 0.999560479 0.035570951 0.032444979 GOTERM_BP_DIRECT GO:0060397~JAK-STAT cascade involved in growth hormone signaling pathway 3 1.875 0.002826399 "STAT3, JAK3, JAK1" 159 10 19453 36.70377358 0.999560479 0.035570951 0.032444979 GOTERM_BP_DIRECT GO:0010042~response to manganese ion 3 1.875 0.002826399 "ARG1, TSPO, PTGS2" 159 10 19453 36.70377358 0.999560479 0.035570951 0.032444979 GOTERM_BP_DIRECT GO:0090050~positive regulation of cell migration involved in sprouting angiogenesis 4 2.5 0.002843544 "KDR, PTGS2, HDAC9, VEGFA" 159 35 19453 13.98238994 0.99958064 0.035622563 0.032492055 GOTERM_BP_DIRECT GO:0019369~arachidonic acid metabolic process 4 2.5 0.003083727 "ALOX5, EPHX1, CYP1B1, PLA2G4A" 159 36 19453 13.59399022 0.999782795 0.038455056 0.03507563 GOTERM_BP_DIRECT GO:0030163~protein catabolic process 5 3.125 0.003255311 "P2RX7, MME, MMP2, AKT1, ELANE" 159 75 19453 8.15639413 0.999864258 0.040370134 0.036822411 GOTERM_BP_DIRECT "GO:0045892~negative regulation of transcription, DNA-templated" 13 8.125 0.003266862 "HDAC4, HSPA8, JUN, PARP1, HDAC1, SRC, AHR, NR3C1, HDAC9, CDK5, APEX1, PPARG, PPARD" 159 591 19453 2.691196033 0.999868487 0.040370134 0.036822411 GOTERM_BP_DIRECT GO:0010976~positive regulation of neuron projection development 6 3.75 0.003322253 "CAMK2B, RET, NTRK2, HSPA5, CNR1, EP300" 159 123 19453 5.968093266 0.999887006 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:2000352~negative regulation of endothelial cell apoptotic process 4 2.5 0.003336008 "TERT, SERPINE1, KDR, BRAF" 159 37 19453 13.22658508 0.999891186 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0060326~cell chemotaxis 5 3.125 0.003414763 "PDGFRB, PDGFRA, ABCC1, KIT, PRKCD" 159 76 19453 8.049073155 0.999912308 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0050665~hydrogen peroxide biosynthetic process 3 1.875 0.003436112 "MAOB, CYP1A2, CYP1A1" 159 11 19453 33.3670669 0.999917291 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0035723~interleukin-15-mediated signaling pathway 3 1.875 0.003436112 "STAT3, JAK3, JAK1" 159 11 19453 33.3670669 0.999917291 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:1900015~regulation of cytokine production involved in inflammatory response 3 1.875 0.003436112 "NOS2, ALOX5, MAPK14" 159 11 19453 33.3670669 0.999917291 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0019370~leukotriene biosynthetic process 3 1.875 0.003436112 "SYK, ALOX5, PLA2G4A" 159 11 19453 33.3670669 0.999917291 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0050847~progesterone receptor signaling pathway 3 1.875 0.003436112 "SRC, MAPK1, PGR" 159 11 19453 33.3670669 0.999917291 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0010887~negative regulation of cholesterol storage 3 1.875 0.003436112 "PPARG, PPARA, PPARD" 159 11 19453 33.3670669 0.999917291 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0042420~dopamine catabolic process 3 1.875 0.003436112 "MAOB, MAOA, COMT" 159 11 19453 33.3670669 0.999917291 0.040623467 0.037053481 GOTERM_BP_DIRECT GO:0048709~oligodendrocyte differentiation 4 2.5 0.003600575 "NTRK2, CDK5, HDAC1, ERBB2" 159 38 19453 12.87851705 0.999947301 0.041843283 0.038166099 GOTERM_BP_DIRECT GO:0014065~phosphatidylinositol 3-kinase signaling 4 2.5 0.003600575 "ERBB2, AKT1, HTR2A, PIK3CG" 159 38 19453 12.87851705 0.999947301 0.041843283 0.038166099 GOTERM_BP_DIRECT GO:0031333~negative regulation of protein complex assembly 4 2.5 0.003600575 "GSK3B, HSPA5, SRC, EP300" 159 38 19453 12.87851705 0.999947301 0.041843283 0.038166099 GOTERM_BP_DIRECT GO:0006139~nucleobase-containing compound metabolic process 4 2.5 0.003600575 "PNP, TPMT, TK1, SLC29A1" 159 38 19453 12.87851705 0.999947301 0.041843283 0.038166099 GOTERM_BP_DIRECT GO:0010634~positive regulation of epithelial cell migration 4 2.5 0.003877612 "JUN, SRC, TACR1, PTK2" 159 39 19453 12.54829866 0.99997534 0.044871857 0.040928523 GOTERM_BP_DIRECT GO:0050927~positive regulation of positive chemotaxis 3 1.875 0.004101414 "KDR, F3, VEGFA" 159 12 19453 30.58647799 0.99998665 0.046525704 0.04243703 GOTERM_BP_DIRECT GO:0033327~Leydig cell differentiation 3 1.875 0.004101414 "PDGFRA, AR, CCND1" 159 12 19453 30.58647799 0.99998665 0.046525704 0.04243703 GOTERM_BP_DIRECT GO:0016572~histone phosphorylation 3 1.875 0.004101414 "CDK5, CDK2, PRKCD" 159 12 19453 30.58647799 0.99998665 0.046525704 0.04243703 GOTERM_BP_DIRECT GO:0097267~omega-hydroxylase P450 pathway 3 1.875 0.004101414 "CYP1A2, CYP1A1, CYP1B1" 159 12 19453 30.58647799 0.99998665 0.046525704 0.04243703 GOTERM_BP_DIRECT GO:0002244~hematopoietic progenitor cell differentiation 5 3.125 0.00410571 "PDGFRA, CSF1R, FLT1, KIT, KDR" 159 80 19453 7.646619497 0.999986806 0.046525704 0.04243703 GOTERM_BP_DIRECT GO:0071392~cellular response to estradiol stimulus 4 2.5 0.004167292 "MMP2, SSTR2, ESR1, EGFR" 159 40 19453 12.23459119 0.999988857 0.046834876 0.042719032 GOTERM_BP_DIRECT GO:0031100~animal organ regeneration 4 2.5 0.004167292 "ACE, FLT3, CDK1, PPARG" 159 40 19453 12.23459119 0.999988857 0.046834876 0.042719032 GOTERM_BP_DIRECT GO:0048286~lung alveolus development 4 2.5 0.004469784 "ACE, KDR, PGR, ADA" 159 41 19453 11.93618653 0.999995139 0.049781739 0.045406925 GOTERM_BP_DIRECT GO:0030574~collagen catabolic process 4 2.5 0.004469784 "MMP1, MMP2, MMP9, CTSB" 159 41 19453 11.93618653 0.999995139 0.049781739 0.045406925 GOTERM_BP_DIRECT GO:0051402~neuron apoptotic process 5 3.125 0.004484185 "APP, CDK5, HSPA5, GAPDH, SNCA" 159 82 19453 7.460116582 0.999995328 0.049781739 0.045406925 GOTERM_BP_DIRECT GO:0008217~regulation of blood pressure 5 3.125 0.004681946 "ACE, ANPEP, PPARG, PTGS2, PTGS1" 159 83 19453 7.37023566 0.999997284 0.051766774 0.047217515 GOTERM_BP_DIRECT GO:0001541~ovarian follicle development 4 2.5 0.004785249 "MMP2, KIT, KDR, VEGFA" 159 42 19453 11.65199161 0.999997955 0.052250685 0.0476589 GOTERM_BP_DIRECT GO:0031663~lipopolysaccharide-mediated signaling pathway 4 2.5 0.004785249 "MAPK1, AKT1, MAPK14, TLR4" 159 42 19453 11.65199161 0.999997955 0.052250685 0.0476589 GOTERM_BP_DIRECT GO:0014912~negative regulation of smooth muscle cell migration 3 1.875 0.004821374 "APEX1, SERPINE1, PPARD" 159 13 19453 28.23367199 0.999998148 0.052250685 0.0476589 GOTERM_BP_DIRECT GO:0051918~negative regulation of fibrinolysis 3 1.875 0.004821374 "SERPINE1, PLG, F2" 159 13 19453 28.23367199 0.999998148 0.052250685 0.0476589 GOTERM_BP_DIRECT GO:0033993~response to lipid 3 1.875 0.004821374 "PPARG, PPARA, PPARD" 159 13 19453 28.23367199 0.999998148 0.052250685 0.0476589 GOTERM_BP_DIRECT GO:0032733~positive regulation of interleukin-10 production 4 2.5 0.005113842 "SYK, STAT3, TLR9, TLR4" 159 43 19453 11.38101507 0.99999917 0.054983871 0.050151894 GOTERM_BP_DIRECT GO:0007595~lactation 4 2.5 0.005113842 "CCND1, SLC29A1, XDH, VEGFA" 159 43 19453 11.38101507 0.99999917 0.054983871 0.050151894 GOTERM_BP_DIRECT GO:0031571~mitotic G1 DNA damage checkpoint 3 1.875 0.005595072 "CCND1, PRKDC, CDK2" 159 14 19453 26.21698113 0.999999779 0.058544606 0.053399712 GOTERM_BP_DIRECT GO:0061029~eyelid development in camera-type eye 3 1.875 0.005595072 "JUN, HDAC1, EGFR" 159 14 19453 26.21698113 0.999999779 0.058544606 0.053399712 GOTERM_BP_DIRECT GO:0045820~negative regulation of glycolytic process 3 1.875 0.005595072 "HDAC4, STAT3, PPARA" 159 14 19453 26.21698113 0.999999779 0.058544606 0.053399712 GOTERM_BP_DIRECT GO:0070102~interleukin-6-mediated signaling pathway 3 1.875 0.005595072 "SRC, STAT3, JAK1" 159 14 19453 26.21698113 0.999999779 0.058544606 0.053399712 GOTERM_BP_DIRECT GO:0010389~regulation of G2/M transition of mitotic cell cycle 3 1.875 0.005595072 "CDK6, CDK2, AURKA" 159 14 19453 26.21698113 0.999999779 0.058544606 0.053399712 GOTERM_BP_DIRECT GO:0001878~response to yeast 3 1.875 0.005595072 "APP, MPO, ELANE" 159 14 19453 26.21698113 0.999999779 0.058544606 0.053399712 GOTERM_BP_DIRECT GO:0048148~behavioral response to cocaine 3 1.875 0.005595072 "CDK5, HTR2A, DRD2" 159 14 19453 26.21698113 0.999999779 0.058544606 0.053399712 GOTERM_BP_DIRECT GO:0007566~embryo implantation 4 2.5 0.005811002 "MMP2, PTGS2, MMP9, PPARD" 159 45 19453 10.87519217 0.999999878 0.060341622 0.055038807 GOTERM_BP_DIRECT GO:0009755~hormone-mediated signaling pathway 4 2.5 0.005811002 "THRB, PPARG, PPARA, PPARD" 159 45 19453 10.87519217 0.999999878 0.060341622 0.055038807 GOTERM_BP_DIRECT GO:0007613~memory 5 3.125 0.00599261 "APP, CNR1, MAPT, HTR2A, PTGS2" 159 89 19453 6.87336584 0.999999926 0.061991738 0.05654391 GOTERM_BP_DIRECT GO:0030890~positive regulation of B cell proliferation 4 2.5 0.006179847 "TLR9, MIF, TLR4, ADA" 159 46 19453 10.63877495 0.999999956 0.063687408 0.058090565 GOTERM_BP_DIRECT GO:0051726~regulation of cell cycle 8 5 0.006380084 "HSPA8, JUN, CDK6, HSP90AB1, CSNK2A1, CDK5, STAT3, TGFBR1" 159 268 19453 3.652116775 0.999999974 0.065503794 0.059747328 GOTERM_BP_DIRECT GO:0097067~cellular response to thyroid hormone stimulus 3 1.875 0.006421599 "THRB, KIT, CTSB" 159 15 19453 24.46918239 0.999999977 0.065683095 0.059910872 GOTERM_BP_DIRECT GO:0048870~cell motility 4 2.5 0.006562378 "ADAM17, MAP2K1, PTK2, TGFBR1" 159 47 19453 10.41241804 0.999999984 0.066623998 0.060769088 GOTERM_BP_DIRECT GO:0046427~positive regulation of JAK-STAT cascade 4 2.5 0.006562378 "KIT, EP300, CYP1B1, F2" 159 47 19453 10.41241804 0.999999984 0.066623998 0.060769088 GOTERM_BP_DIRECT GO:0071407~cellular response to organic cyclic compound 4 2.5 0.00695872 "HSP90AB1, CYP1A1, CDK1, CYP1B1" 159 48 19453 10.19549266 0.999999995 0.070386162 0.064200633 GOTERM_BP_DIRECT GO:0031647~regulation of protein stability 5 3.125 0.00698992 "HSPA8, TERT, MAPK1, HDAC8, AURKA" 159 93 19453 6.577737202 0.999999995 0.070440849 0.064250515 GOTERM_BP_DIRECT GO:2000310~regulation of NMDA receptor activity 3 1.875 0.007300056 "APP, DAPK1, OPRM1" 159 16 19453 22.93985849 0.999999998 0.072496193 0.066125235 GOTERM_BP_DIRECT GO:0097435~supramolecular fiber organization 3 1.875 0.007300056 "HSP90AB1, MAPT, SNCA" 159 16 19453 22.93985849 0.999999998 0.072496193 0.066125235 GOTERM_BP_DIRECT GO:0090399~replicative senescence 3 1.875 0.007300056 "TERT, MME, SERPINE1" 159 16 19453 22.93985849 0.999999998 0.072496193 0.066125235 GOTERM_BP_DIRECT GO:0095500~acetylcholine receptor signaling pathway 3 1.875 0.007300056 "ACHE, CHRM3, CHRNA3" 159 16 19453 22.93985849 0.999999998 0.072496193 0.066125235 GOTERM_BP_DIRECT GO:0007200~phospholipase C-activating G-protein coupled receptor signaling pathway 5 3.125 0.007527313 "TACR1, HTR2A, OPRM1, DRD2, ESR1" 159 95 19453 6.439258524 0.999999999 0.07421333 0.06769147 GOTERM_BP_DIRECT GO:0050829~defense response to Gram-negative bacterium 5 3.125 0.007527313 "APP, NOS2, SERPINE1, TLR9, TLR4" 159 95 19453 6.439258524 0.999999999 0.07421333 0.06769147 GOTERM_BP_DIRECT GO:0048013~ephrin receptor signaling pathway 4 2.5 0.007793302 "SRC, MMP2, MMP9, PTK2" 159 50 19453 9.787672956 0.999999999 0.076408575 0.069693798 GOTERM_BP_DIRECT GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation 5 3.125 0.007805929 "SYK, SRC, MIF, HTR2A, VEGFA" 159 96 19453 6.372182914 0.999999999 0.076408575 0.069693798 GOTERM_BP_DIRECT GO:0008360~regulation of cell shape 6 3.75 0.007854509 "CSF1R, KIT, KDR, F2, PTK2, VEGFA" 159 151 19453 4.861426965 1 0.076609518 0.069877081 GOTERM_BP_DIRECT GO:0045987~positive regulation of smooth muscle contraction 3 1.875 0.008229557 "CHRM3, PTGS2, ADA" 159 17 19453 21.59045505 1 0.079137039 0.072182484 GOTERM_BP_DIRECT GO:0016486~peptide hormone processing 3 1.875 0.008229557 "DPP4, BCHE, PLA2G7" 159 17 19453 21.59045505 1 0.079137039 0.072182484 GOTERM_BP_DIRECT GO:0055093~response to hyperoxia 3 1.875 0.008229557 "PDGFRB, MMP2, CYP1A1" 159 17 19453 21.59045505 1 0.079137039 0.072182484 GOTERM_BP_DIRECT GO:0071383~cellular response to steroid hormone stimulus 3 1.875 0.008229557 "HSPA8, AR, NR3C1" 159 17 19453 21.59045505 1 0.079137039 0.072182484 GOTERM_BP_DIRECT GO:0034605~cellular response to heat 4 2.5 0.008684473 "HSP90AB1, TRPV1, MAPT, PTGS2" 159 52 19453 9.411223996 1 0.082927609 0.075639939 GOTERM_BP_DIRECT GO:1904263~positive regulation of TORC1 signaling 4 2.5 0.008684473 "SYK, SRC, EP300, AKT1" 159 52 19453 9.411223996 1 0.082927609 0.075639939 GOTERM_BP_DIRECT GO:0016575~histone deacetylation 4 2.5 0.009151531 "HDAC4, HDAC1, HDAC8, HDAC9" 159 53 19453 9.233653732 1 0.086725487 0.07910406 GOTERM_BP_DIRECT GO:0034374~low-density lipoprotein particle remodeling 3 1.875 0.009209224 "PLA2G2A, MPO, PLA2G7" 159 18 19453 20.39098532 1 0.086725487 0.07910406 GOTERM_BP_DIRECT GO:0060065~uterus development 3 1.875 0.009209224 "SRC, ESR1, CYP19A1" 159 18 19453 20.39098532 1 0.086725487 0.07910406 GOTERM_BP_DIRECT GO:0010469~regulation of receptor activity 3 1.875 0.009209224 "APP, PRKCD, SERPINE1" 159 18 19453 20.39098532 1 0.086725487 0.07910406 GOTERM_BP_DIRECT GO:0051209~release of sequestered calcium ion into cytosol 4 2.5 0.009633027 "P2RX7, TRPV1, HTR2A, DRD2" 159 54 19453 9.062660144 1 0.090404802 0.082460037 GOTERM_BP_DIRECT GO:0031334~positive regulation of protein complex assembly 4 2.5 0.010129047 "GSK3B, SYK, MMP1, VEGFA" 159 55 19453 8.897884505 1 0.094734342 0.086409098 GOTERM_BP_DIRECT GO:0045780~positive regulation of bone resorption 3 1.875 0.010238193 "SYK, SRC, PRKCA" 159 19 19453 19.31777557 1 0.094781374 0.086451996 GOTERM_BP_DIRECT GO:0042730~fibrinolysis 3 1.875 0.010238193 "SERPINE1, PLG, F2" 159 19 19453 19.31777557 1 0.094781374 0.086451996 GOTERM_BP_DIRECT GO:0051403~stress-activated MAPK cascade 3 1.875 0.010238193 "IKBKB, MAPK1, MAPK14" 159 19 19453 19.31777557 1 0.094781374 0.086451996 GOTERM_BP_DIRECT GO:0045600~positive regulation of fat cell differentiation 4 2.5 0.011164977 "AKT1, PPARG, HTR2A, PPARD" 159 57 19453 8.585678032 1 0.10266753 0.093645118 GOTERM_BP_DIRECT GO:0071318~cellular response to ATP 3 1.875 0.011315608 "P2RX7, TRPV1, PTGS2" 159 20 19453 18.35188679 1 0.10266753 0.093645118 GOTERM_BP_DIRECT GO:0021954~central nervous system neuron development 3 1.875 0.011315608 "NTRK2, CDK5, MAPT" 159 20 19453 18.35188679 1 0.10266753 0.093645118 GOTERM_BP_DIRECT GO:0060716~labyrinthine layer blood vessel development 3 1.875 0.011315608 "MAPK1, AKT1, PLG" 159 20 19453 18.35188679 1 0.10266753 0.093645118 GOTERM_BP_DIRECT GO:0048514~blood vessel morphogenesis 3 1.875 0.011315608 "FLT1, SYK, CYP1B1" 159 20 19453 18.35188679 1 0.10266753 0.093645118 GOTERM_BP_DIRECT GO:0010759~positive regulation of macrophage chemotaxis 3 1.875 0.011315608 "CSF1R, MAPK1, PTK2" 159 20 19453 18.35188679 1 0.10266753 0.093645118 GOTERM_BP_DIRECT GO:0007612~learning 4 2.5 0.012259908 "NTRK2, BCHE, APP, PTGS2" 159 59 19453 8.294638098 1 0.110137528 0.100458654 GOTERM_BP_DIRECT GO:0031397~negative regulation of protein ubiquitination 4 2.5 0.012259908 "CDK5, TSPO, AKT1, HDAC8" 159 59 19453 8.294638098 1 0.110137528 0.100458654 GOTERM_BP_DIRECT GO:0045597~positive regulation of cell differentiation 4 2.5 0.012259908 "GSK3B, AR, HSP90AB1, FGFR1" 159 59 19453 8.294638098 1 0.110137528 0.100458654 GOTERM_BP_DIRECT GO:0009615~response to virus 5 3.125 0.012437685 "IKBKB, CDK6, SRC, ODC1, CYP1A1" 159 110 19453 5.561177816 1 0.110668887 0.100943316 GOTERM_BP_DIRECT GO:0042759~long-chain fatty acid biosynthetic process 3 1.875 0.012440626 "ALOX5, CYP1A2, CYP1A1" 159 21 19453 17.47798742 1 0.110668887 0.100943316 GOTERM_BP_DIRECT GO:0043401~steroid hormone mediated signaling pathway 3 1.875 0.012440626 "MAPK1, PPARA, PPARD" 159 21 19453 17.47798742 1 0.110668887 0.100943316 GOTERM_BP_DIRECT GO:0000723~telomere maintenance 4 2.5 0.012829661 "TERT, PARP1, PRKDC, APEX1" 159 60 19453 8.15639413 1 0.113759106 0.103761968 GOTERM_BP_DIRECT GO:0001659~temperature homeostasis 3 1.875 0.01361241 "STAT3, HTR2A, DRD2" 159 22 19453 16.68353345 1 0.118771541 0.10833391 GOTERM_BP_DIRECT GO:0019373~epoxygenase P450 pathway 3 1.875 0.01361241 "CYP1A2, CYP1A1, CYP1B1" 159 22 19453 16.68353345 1 0.118771541 0.10833391 GOTERM_BP_DIRECT GO:0002042~cell migration involved in sprouting angiogenesis 3 1.875 0.01361241 "KDR, AKT1, VEGFA" 159 22 19453 16.68353345 1 0.118771541 0.10833391 GOTERM_BP_DIRECT GO:0006939~smooth muscle contraction 3 1.875 0.01361241 "CHRM3, ADA, MYLK" 159 22 19453 16.68353345 1 0.118771541 0.10833391 GOTERM_BP_DIRECT GO:0002755~MyD88-dependent toll-like receptor signaling pathway 3 1.875 0.01361241 "IKBKB, TLR9, TLR4" 159 22 19453 16.68353345 1 0.118771541 0.10833391 GOTERM_BP_DIRECT GO:0030512~negative regulation of transforming growth factor beta receptor signaling pathway 5 3.125 0.014024604 "ADAM17, HSPA5, HDAC1, PPARG, PPARA" 159 114 19453 5.36604877 1 0.121978319 0.111258877 GOTERM_BP_DIRECT GO:0045861~negative regulation of proteolysis 3 1.875 0.014830139 "CDK5, AKT1, F2" 159 23 19453 15.95816243 1 0.127763751 0.116535885 GOTERM_BP_DIRECT GO:0060324~face development 3 1.875 0.014830139 "MAP2K1, MAPK1, BRAF" 159 23 19453 15.95816243 1 0.127763751 0.116535885 GOTERM_BP_DIRECT GO:0090026~positive regulation of monocyte chemotaxis 3 1.875 0.014830139 "APP, SERPINE1, PLA2G7" 159 23 19453 15.95816243 1 0.127763751 0.116535885 GOTERM_BP_DIRECT GO:0071230~cellular response to amino acid stimulus 4 2.5 0.015258534 "NTRK2, PDGFRA, MMP2, EGFR" 159 64 19453 7.646619497 1 0.131041055 0.11952518 GOTERM_BP_DIRECT GO:0043488~regulation of mRNA stability 4 2.5 0.015903445 "APEX1, PRKCD, AKT1, PRKCA" 159 65 19453 7.528979197 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0043278~response to morphine 3 1.875 0.016092997 "CNR1, TACR1, DRD2" 159 24 19453 15.29323899 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0045821~positive regulation of glycolytic process 3 1.875 0.016092997 "P2RX7, APP, HTR2A" 159 24 19453 15.29323899 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0043473~pigmentation 3 1.875 0.016092997 "KIT, TYR, DRD2" 159 24 19453 15.29323899 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0043303~mast cell degranulation 3 1.875 0.016092997 "SYK, KIT, PIK3CG" 159 24 19453 15.29323899 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0006149~deoxyinosine catabolic process 2 1.25 0.016178726 "PNP, XDH" 159 2 19453 122.3459119 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0006581~acetylcholine catabolic process 2 1.25 0.016178726 "ACHE, BCHE" 159 2 19453 122.3459119 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0006148~inosine catabolic process 2 1.25 0.016178726 "PNP, XDH" 159 2 19453 122.3459119 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0019858~cytosine metabolic process 2 1.25 0.016178726 "CDA, MAPK1" 159 2 19453 122.3459119 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:1903421~regulation of synaptic vesicle recycling 2 1.25 0.016178726 "CDK5, SNCA" 159 2 19453 122.3459119 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0043101~purine-containing compound salvage 2 1.25 0.016178726 "PNP, ADA" 159 2 19453 122.3459119 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0001822~kidney development 5 3.125 0.01618165 "ACE, MME, ODC1, TGFBR1, VEGFA" 159 119 19453 5.140584536 1 0.133915416 0.122146943 GOTERM_BP_DIRECT GO:0005975~carbohydrate metabolic process 6 3.75 0.016232438 "GSK3B, MGAM, ALDH2, GAA, AKR1B1, GUSB" 159 181 19453 4.055665589 1 0.133929872 0.122160128 GOTERM_BP_DIRECT GO:0050680~negative regulation of epithelial cell proliferation 4 2.5 0.016563511 "AR, CDK6, DRD2, PPARD" 159 66 19453 7.414903755 1 0.136249842 0.12427622 GOTERM_BP_DIRECT GO:0032731~positive regulation of interleukin-1 beta production 4 2.5 0.017238761 "P2RX7, APP, STAT3, TLR4" 159 67 19453 7.304233549 1 0.141378547 0.128954215 GOTERM_BP_DIRECT GO:0071385~cellular response to glucocorticoid stimulus 3 1.875 0.017400182 "FLT3, SSTR2, NR3C1" 159 25 19453 14.68150943 1 0.141428264 0.128999563 GOTERM_BP_DIRECT GO:0071353~cellular response to interleukin-4 3 1.875 0.017400182 "HSP90AB1, HSPA5, ARG1" 159 25 19453 14.68150943 1 0.141428264 0.128999563 GOTERM_BP_DIRECT GO:0051000~positive regulation of nitric-oxide synthase activity 3 1.875 0.017400182 "TERT, AKT1, ESR1" 159 25 19453 14.68150943 1 0.141428264 0.128999563 GOTERM_BP_DIRECT GO:0042593~glucose homeostasis 5 3.125 0.018049373 "CNR1, ALOX5, STAT3, AKT1, PPARG" 159 123 19453 4.973411055 1 0.146269544 0.133415392 GOTERM_BP_DIRECT GO:0000082~G1/S transition of mitotic cell cycle 4 2.5 0.01863492 "CDK6, CCND1, CDK2, CDK1" 159 69 19453 7.092516635 1 0.15056795 0.137336054 GOTERM_BP_DIRECT GO:1900273~positive regulation of long-term synaptic potentiation 3 1.875 0.018750899 "APP, MME, DRD2" 159 26 19453 14.11683599 1 0.151058128 0.137783155 GOTERM_BP_DIRECT GO:0006979~response to oxidative stress 5 3.125 0.019031457 "APP, AKT1, PTGS2, MPO, PTGS1" 159 125 19453 4.893836478 1 0.152419085 0.139024511 GOTERM_BP_DIRECT GO:0006935~chemotaxis 5 3.125 0.019031457 "PDGFRB, MAP2K1, MAPK1, MAPK14, TYMP" 159 125 19453 4.893836478 1 0.152419085 0.139024511 GOTERM_BP_DIRECT GO:0001819~positive regulation of cytokine production 4 2.5 0.019355872 "SRC, MIF, GAPDH, PIK3CG" 159 70 19453 6.991194969 1 0.154563992 0.140980924 GOTERM_BP_DIRECT GO:0042742~defense response to bacterium 7 4.375 0.019971845 "SYK, NOS2, PRKCD, TLR9, MPO, TLR4, ELANE" 159 261 19453 3.281307983 1 0.15901781 0.145043342 GOTERM_BP_DIRECT GO:0071466~cellular response to xenobiotic stimulus 4 2.5 0.020092093 "KCNH2, NOS2, HSPA5, BRAF" 159 71 19453 6.892727434 1 0.159461623 0.145448152 GOTERM_BP_DIRECT GO:0071280~cellular response to copper ion 3 1.875 0.020144365 "APP, CYP1A1, SNCA" 159 27 19453 13.59399022 1 0.159461623 0.145448152 GOTERM_BP_DIRECT GO:0050679~positive regulation of epithelial cell proliferation 4 2.5 0.020843595 "ERBB2, TACR1, EGFR, VEGFA" 159 72 19453 6.796995108 1 0.1640457 0.149629381 GOTERM_BP_DIRECT GO:0007416~synapse assembly 4 2.5 0.020843595 "ACHE, CDK5, MAPT, DRD2" 159 72 19453 6.796995108 1 0.1640457 0.149629381 GOTERM_BP_DIRECT GO:2000773~negative regulation of cellular senescence 3 1.875 0.021579805 "CDK6, TERT, MIF" 159 28 19453 13.10849057 1 0.166717421 0.152066311 GOTERM_BP_DIRECT GO:0060391~positive regulation of SMAD protein import into nucleus 3 1.875 0.021579805 "PARP1, PPARG, TGFBR1" 159 28 19453 13.10849057 1 0.166717421 0.152066311 GOTERM_BP_DIRECT GO:1905564~positive regulation of vascular endothelial cell proliferation 3 1.875 0.021579805 "ADAM17, STAT3, FGFR1" 159 28 19453 13.10849057 1 0.166717421 0.152066311 GOTERM_BP_DIRECT GO:0002092~positive regulation of receptor internalization 3 1.875 0.021579805 "SYK, DRD2, VEGFA" 159 28 19453 13.10849057 1 0.166717421 0.152066311 GOTERM_BP_DIRECT GO:0050900~leukocyte migration 3 1.875 0.021579805 "SRC, MMP9, ADA" 159 28 19453 13.10849057 1 0.166717421 0.152066311 GOTERM_BP_DIRECT GO:0051928~positive regulation of calcium ion transport 3 1.875 0.021579805 "TSPO, JAK3, MYLK" 159 28 19453 13.10849057 1 0.166717421 0.152066311 GOTERM_BP_DIRECT GO:0097190~apoptotic signaling pathway 4 2.5 0.021610387 "P2RX7, DAPK1, PRKCA, PPARD" 159 73 19453 6.703885586 1 0.166717421 0.152066311 GOTERM_BP_DIRECT GO:0010971~positive regulation of G2/M transition of mitotic cell cycle 3 1.875 0.023056454 "APP, CCND1, CDK1" 159 29 19453 12.65647365 1 0.17687409 0.161330413 GOTERM_BP_DIRECT GO:0061098~positive regulation of protein tyrosine kinase activity 3 1.875 0.023056454 "CSF1R, APP, ACE" 159 29 19453 12.65647365 1 0.17687409 0.161330413 GOTERM_BP_DIRECT GO:0009611~response to wounding 4 2.5 0.02400253 "CDK5, CYP1A1, F2, AURKA" 159 76 19453 6.439258524 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0018076~N-terminal peptidyl-lysine acetylation 2 1.25 0.024170282 "CREBBP, EP300" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0002730~regulation of dendritic cell cytokine production 2 1.25 0.024170282 "TLR9, TLR4" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0021697~cerebellar cortex formation 2 1.25 0.024170282 "MAP2K1, CDK5" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0010814~substance P catabolic process 2 1.25 0.024170282 "ACE, MME" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0072277~metanephric glomerular capillary formation 2 1.25 0.024170282 "PDGFRB, PDGFRA" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0097176~epoxide metabolic process 2 1.25 0.024170282 "EPHX2, EPHX1" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0060748~tertiary branching involved in mammary gland duct morphogenesis 2 1.25 0.024170282 "AR, PGR" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:1905039~carboxylic acid transmembrane transport 2 1.25 0.024170282 "ABCC1, ABCB1" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0033632~regulation of cell-cell adhesion mediated by integrin 2 1.25 0.024170282 "DPP4, ADA" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0002679~respiratory burst involved in defense response 2 1.25 0.024170282 "MPO, PIK3CG" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:0060083~smooth muscle contraction involved in micturition 2 1.25 0.024170282 "TRPV1, TACR1" 159 3 19453 81.5639413 1 0.179372394 0.163609167 GOTERM_BP_DIRECT GO:1990000~amyloid fibril formation 3 1.875 0.024573558 "APP, MAPT, SNCA" 159 30 19453 12.23459119 1 0.181870968 0.165888166 GOTERM_BP_DIRECT GO:0071260~cellular response to mechanical stimulus 4 2.5 0.025673735 "HDAC4, PTGS2, TLR4, PLEC" 159 78 19453 6.274149331 1 0.189499918 0.172846684 GOTERM_BP_DIRECT GO:0030878~thyroid gland development 3 1.875 0.026130371 "MAP2K1, MAPK1, BRAF" 159 31 19453 11.83992696 1 0.191319151 0.174506043 GOTERM_BP_DIRECT GO:0014059~regulation of dopamine secretion 3 1.875 0.026130371 "HTR2A, DRD2, SNCA" 159 31 19453 11.83992696 1 0.191319151 0.174506043 GOTERM_BP_DIRECT GO:0035987~endodermal cell differentiation 3 1.875 0.026130371 "MAP2K1, MMP2, MMP9" 159 31 19453 11.83992696 1 0.191319151 0.174506043 GOTERM_BP_DIRECT GO:0050772~positive regulation of axonogenesis 3 1.875 0.027726156 "NTRK2, MAP2K1, BRAF" 159 32 19453 11.46992925 1 0.200849158 0.183198555 GOTERM_BP_DIRECT GO:0050769~positive regulation of neurogenesis 3 1.875 0.027726156 "ACE, MME, OPRM1" 159 32 19453 11.46992925 1 0.200849158 0.183198555 GOTERM_BP_DIRECT GO:0060325~face morphogenesis 3 1.875 0.027726156 "PDGFRA, MMP2, EP300" 159 32 19453 11.46992925 1 0.200849158 0.183198555 GOTERM_BP_DIRECT GO:0048008~platelet-derived growth factor receptor signaling pathway 3 1.875 0.027726156 "PDGFRB, PDGFRA, SRC" 159 32 19453 11.46992925 1 0.200849158 0.183198555 GOTERM_BP_DIRECT GO:0001889~liver development 4 2.5 0.030118605 "JUN, ARG1, MET, ADA" 159 83 19453 5.896188528 1 0.21733372 0.198234455 GOTERM_BP_DIRECT GO:0007049~cell cycle 8 5 0.030160923 "CSNK2A1, SRC, PRKCD, EP300, MAPK1, AHR, NR3C1, AURKA" 159 366 19453 2.674227584 1 0.21733372 0.198234455 GOTERM_BP_DIRECT GO:0048705~skeletal system morphogenesis 3 1.875 0.031031744 "P2RX7, TGFBR1, FGFR1" 159 34 19453 10.79522752 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0010033~response to organic substance 3 1.875 0.031031744 "CDK6, CDK2, MMP9" 159 34 19453 10.79522752 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0045931~positive regulation of mitotic cell cycle 3 1.875 0.031031744 "APP, PRKCA, AURKA" 159 34 19453 10.79522752 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0031669~cellular response to nutrient levels 3 1.875 0.031031744 "CREBBP, EP300, PPARD" 159 34 19453 10.79522752 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0002862~negative regulation of inflammatory response to antigenic stimulus 3 1.875 0.031031744 "SYK, SRC, MAPK14" 159 34 19453 10.79522752 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0016310~phosphorylation 7 4.375 0.031767371 "CDK5, STAT3, AKT1, TK1, TOP1, MET, PIK3CG" 159 291 19453 2.94302881 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0007005~mitochondrion organization 4 2.5 0.032002858 "P2RX7, TERT, CDK5, PARP1" 159 85 19453 5.75745468 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0060978~angiogenesis involved in coronary vascular morphogenesis 2 1.25 0.032097331 "ACE, TGFBR1" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0090170~regulation of Golgi inheritance 2 1.25 0.032097331 "MAP2K1, MAPK1" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:1900086~positive regulation of peptidyl-tyrosine autophosphorylation 2 1.25 0.032097331 "ACE, VEGFA" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0048742~regulation of skeletal muscle fiber development 2 1.25 0.032097331 "HDAC4, HDAC9" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0002328~pro-B cell differentiation 2 1.25 0.032097331 "FLT3, PRKDC" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0042447~hormone catabolic process 2 1.25 0.032097331 "ACE, MME" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0070495~negative regulation of thrombin-activated receptor signaling pathway 2 1.25 0.032097331 "MET, SNCA" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0060571~morphogenesis of an epithelial fold 2 1.25 0.032097331 "AR, EGFR" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0090258~negative regulation of mitochondrial fission 2 1.25 0.032097331 "PPARG, MAPT" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:1900221~regulation of beta-amyloid clearance 2 1.25 0.032097331 "APP, HDAC1" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0002906~negative regulation of mature B cell apoptotic process 2 1.25 0.032097331 "MIF, ADA" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0035377~transepithelial water transport 2 1.25 0.032097331 "SLC5A1, CFTR" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0070945~neutrophil mediated killing of gram-negative bacterium 2 1.25 0.032097331 "F2, ELANE" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0006475~internal protein amino acid acetylation 2 1.25 0.032097331 "EP300, MAPT" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0032079~positive regulation of endodeoxyribonuclease activity 2 1.25 0.032097331 "PRKCD, AKT1" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0006154~adenosine catabolic process 2 1.25 0.032097331 "XDH, ADA" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0032765~positive regulation of mast cell cytokine production 2 1.25 0.032097331 "SYK, KIT" 159 4 19453 61.17295597 1 0.217513178 0.198398143 GOTERM_BP_DIRECT GO:0032147~activation of protein kinase activity 3 1.875 0.03274012 "PRKCD, DRD2, VEGFA" 159 35 19453 10.48679245 1 0.220773502 0.201371949 GOTERM_BP_DIRECT GO:0045648~positive regulation of erythrocyte differentiation 3 1.875 0.03274012 "PRKDC, STAT3, MAPK14" 159 35 19453 10.48679245 1 0.220773502 0.201371949 GOTERM_BP_DIRECT GO:0007626~locomotory behavior 4 2.5 0.032967651 "APP, CHRNA3, GAA, DRD2" 159 86 19453 5.690507533 1 0.22121537 0.201774986 GOTERM_BP_DIRECT GO:0016485~protein processing 4 2.5 0.032967651 "P2RX7, ADAM17, MME, F3" 159 86 19453 5.690507533 1 0.22121537 0.201774986 GOTERM_BP_DIRECT GO:0043542~endothelial cell migration 3 1.875 0.034484614 "DPP4, CYP1B1, TGFBR1" 159 36 19453 10.19549266 1 0.229701173 0.209515057 GOTERM_BP_DIRECT GO:0032570~response to progesterone 3 1.875 0.034484614 "TSPO, TACR1, TYMS" 159 36 19453 10.19549266 1 0.229701173 0.209515057 GOTERM_BP_DIRECT GO:0097421~liver regeneration 3 1.875 0.034484614 "CCND1, TYMS, AURKA" 159 36 19453 10.19549266 1 0.229701173 0.209515057 GOTERM_BP_DIRECT GO:0006974~cellular response to DNA damage stimulus 7 4.375 0.035057475 "CCND1, PARP1, PRKDC, PRKCD, MAPK1, MAPT, MCL1" 159 298 19453 2.873897261 1 0.232948816 0.212477298 GOTERM_BP_DIRECT GO:0008306~associative learning 3 1.875 0.036264534 "APP, TACR1, DRD2" 159 37 19453 9.919938807 1 0.238073181 0.217151334 GOTERM_BP_DIRECT GO:0046326~positive regulation of glucose import 3 1.875 0.036264534 "TERT, AKT1, MAPK14" 159 37 19453 9.919938807 1 0.238073181 0.217151334 GOTERM_BP_DIRECT GO:0030010~establishment of cell polarity 3 1.875 0.036264534 "GSK3B, HSP90AB1, PTK2" 159 37 19453 9.919938807 1 0.238073181 0.217151334 GOTERM_BP_DIRECT GO:2001237~negative regulation of extrinsic apoptotic signaling pathway 3 1.875 0.036264534 "AR, SRC, TGFBR1" 159 37 19453 9.919938807 1 0.238073181 0.217151334 GOTERM_BP_DIRECT GO:2001240~negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 3 1.875 0.036264534 "TERT, AKT1, MCL1" 159 37 19453 9.919938807 1 0.238073181 0.217151334 GOTERM_BP_DIRECT GO:0048469~cell maturation 3 1.875 0.038079199 "KDR, PPARG, VEGFA" 159 38 19453 9.658887786 1 0.248790172 0.226926517 GOTERM_BP_DIRECT GO:0048678~response to axon injury 3 1.875 0.038079199 "ARG1, CDK1, DRD2" 159 38 19453 9.658887786 1 0.248790172 0.226926517 GOTERM_BP_DIRECT GO:0019722~calcium-mediated signaling 4 2.5 0.039071399 "CHRM3, APP, SYK, ADA" 159 92 19453 5.319387476 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0001937~negative regulation of endothelial cell proliferation 3 1.875 0.039927933 "ALOX5, XDH, TGFBR1" 159 39 19453 9.411223996 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0031622~positive regulation of fever generation 2 1.25 0.039960389 "CNR1, PTGS2" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0051823~regulation of synapse structural plasticity 2 1.25 0.039960389 "CAMK2B, DRD2" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0006204~IMP catabolic process 2 1.25 0.039960389 "PNP, XDH" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0009635~response to herbicide 2 1.25 0.039960389 "ARG1, CYP1A1" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0033602~negative regulation of dopamine secretion 2 1.25 0.039960389 "CNR1, DRD2" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0006196~AMP catabolic process 2 1.25 0.039960389 "XDH, ADA" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0031999~negative regulation of fatty acid beta-oxidation 2 1.25 0.039960389 "CNR1, AKT1" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0006778~porphyrin-containing compound metabolic process 2 1.25 0.039960389 "CYP1A2, CYP1A1" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0006700~C21-steroid hormone biosynthetic process 2 1.25 0.039960389 "TSPO, AKR1B1" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0038033~positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 2 1.25 0.039960389 "KDR, VEGFA" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0014063~negative regulation of serotonin secretion 2 1.25 0.039960389 "MAOB, CNR1" 159 5 19453 48.93836478 1 0.253206086 0.230954361 GOTERM_BP_DIRECT GO:0017148~negative regulation of translation 4 2.5 0.041224917 "CSNK2A1, DAPK1, TYMS, GAPDH" 159 94 19453 5.206209019 1 0.260614002 0.23771127 GOTERM_BP_DIRECT GO:0071345~cellular response to cytokine stimulus 3 1.875 0.043724959 "CSF1R, MME, FLT3" 159 41 19453 8.952139899 1 0.275144844 0.250965143 GOTERM_BP_DIRECT GO:0019216~regulation of lipid metabolic process 3 1.875 0.043724959 "PPARG, PPARA, PPARD" 159 41 19453 8.952139899 1 0.275144844 0.250965143 GOTERM_BP_DIRECT GO:0034599~cellular response to oxidative stress 4 2.5 0.044565294 "ABCC1, PARP1, GSR, SNCA" 159 97 19453 5.045192245 1 0.279788085 0.255200337 GOTERM_BP_DIRECT GO:1901796~regulation of signal transduction by p53 class mediator 3 1.875 0.045671944 "EP300, AKT1, AURKA" 159 42 19453 8.738993711 1 0.286078164 0.260937645 GOTERM_BP_DIRECT GO:0031295~T cell costimulation 3 1.875 0.047650388 "DPP4, SRC, AKT1" 159 43 19453 8.535761299 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0060603~mammary gland duct morphogenesis 2 1.25 0.047759971 "CSF1R, NR3C1" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:1903038~negative regulation of leukocyte cell-cell adhesion 2 1.25 0.047759971 "AKT1, PPARA" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0014910~regulation of smooth muscle cell migration 2 1.25 0.047759971 "ACE, TACR1" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0036324~vascular endothelial growth factor receptor-2 signaling pathway 2 1.25 0.047759971 "KDR, VEGFA" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0043605~cellular amide catabolic process 2 1.25 0.047759971 "XDH, ADA" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0051583~dopamine uptake involved in synaptic transmission 2 1.25 0.047759971 "DRD2, SNCA" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0010632~regulation of epithelial cell migration 2 1.25 0.047759971 "SRC, PTK2" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0010891~negative regulation of sequestering of triglyceride 2 1.25 0.047759971 "PPARG, PPARA" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0051712~positive regulation of killing of cells of other organism 2 1.25 0.047759971 "SYK, NOS2" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0006706~steroid catabolic process 2 1.25 0.047759971 "STS, CYP1A2" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0072656~maintenance of protein location in mitochondrion 2 1.25 0.047759971 "TSPO, AKT1" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:1903223~positive regulation of oxidative stress-induced neuron death 2 1.25 0.047759971 "APP, TLR4" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0038154~interleukin-11-mediated signaling pathway 2 1.25 0.047759971 "STAT3, JAK1" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0002327~immature B cell differentiation 2 1.25 0.047759971 "PRKDC, KIT" 159 6 19453 40.78197065 1 0.289207273 0.263791767 GOTERM_BP_DIRECT GO:0032956~regulation of actin cytoskeleton organization 4 2.5 0.048036385 "PDGFRB, PDGFRA, CSF1R, PRKCD" 159 100 19453 4.893836478 1 0.289596836 0.264147096 GOTERM_BP_DIRECT GO:0071346~cellular response to interferon-gamma 4 2.5 0.048036385 "NOS2, DAPK1, GAPDH, TLR4" 159 100 19453 4.893836478 1 0.289596836 0.264147096 GOTERM_BP_DIRECT GO:0030855~epithelial cell differentiation 4 2.5 0.049222169 "CDK1, PPARG, CTSB, VEGFA" 159 101 19453 4.845382651 1 0.295441195 0.269477853 GOTERM_BP_DIRECT GO:0042391~regulation of membrane potential 4 2.5 0.049222169 "GABRA2, KCNH2, CHRNA3, HTR3A" 159 101 19453 4.845382651 1 0.295441195 0.269477853 GOTERM_BP_DIRECT GO:0045454~cell redox homeostasis 3 1.875 0.049659658 "NOS2, APEX1, GSR" 159 44 19453 8.341766724 1 0.296114688 0.27009216 GOTERM_BP_DIRECT GO:0042098~T cell proliferation 3 1.875 0.049659658 "P2RX7, PIK3CG, IDO1" 159 44 19453 8.341766724 1 0.296114688 0.27009216 GOTERM_BP_DIRECT GO:0007259~JAK-STAT cascade 3 1.875 0.049659658 "STAT3, JAK3, JAK1" 159 44 19453 8.341766724 1 0.296114688 0.27009216 GOTERM_BP_DIRECT GO:0000902~cell morphogenesis 4 2.5 0.051636466 "P2RX7, MAPK14, EGFR, PLEC" 159 103 19453 4.751297551 1 0.306935492 0.279962033 GOTERM_BP_DIRECT GO:0048863~stem cell differentiation 3 1.875 0.051699131 "KIT, MAPK14, ESR1" 159 45 19453 8.15639413 1 0.306935492 0.279962033 GOTERM_BP_DIRECT GO:0042177~negative regulation of protein catabolic process 3 1.875 0.053768189 "NOS2, HMGCR, EGFR" 159 46 19453 7.979081214 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0050796~regulation of insulin secretion 3 1.875 0.053768189 "NOS2, CNR1, ALOX5" 159 46 19453 7.979081214 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0043407~negative regulation of MAP kinase activity 3 1.875 0.053768189 "PRKCD, PPARG, HMGCR" 159 46 19453 7.979081214 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0045747~positive regulation of Notch signaling pathway 3 1.875 0.053768189 "SRC, STAT3, KIT" 159 46 19453 7.979081214 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0035771~interleukin-4-mediated signaling pathway 2 1.25 0.055496584 "JAK3, JAK1" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0014004~microglia differentiation 2 1.25 0.055496584 "NR3C1, TLR4" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0009624~response to nematode 2 1.25 0.055496584 "CYP1A1, PTGS2" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:1905144~response to acetylcholine 2 1.25 0.055496584 "CHRNA3, TSPO" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:1900122~positive regulation of receptor binding 2 1.25 0.055496584 "APP, MMP9" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0006527~arginine catabolic process 2 1.25 0.055496584 "NOS2, ARG1" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0034440~lipid oxidation 2 1.25 0.055496584 "ALOX5, PLA2G7" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0007167~enzyme linked receptor protein signaling pathway 2 1.25 0.055496584 "ERBB2, JAK3" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0071236~cellular response to antibiotic 2 1.25 0.055496584 "HSPA5, PLA2G4A" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:1990384~hyaloid vascular plexus regression 2 1.25 0.055496584 "FLT1, DRD2" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0010815~bradykinin catabolic process 2 1.25 0.055496584 "ACE, MME" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0051239~regulation of multicellular organismal process 2 1.25 0.055496584 "PTK2, TGFBR1" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0090330~regulation of platelet aggregation 2 1.25 0.055496584 "SYK, PRKCA" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0071393~cellular response to progesterone stimulus 2 1.25 0.055496584 "SRC, CYP1B1" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0044321~response to leptin 2 1.25 0.055496584 "CCND1, STAT3" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0060440~trachea formation 2 1.25 0.055496584 "MAP2K1, MAPK1" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0014012~peripheral nervous system axon regeneration 2 1.25 0.055496584 "MMP2, TSPO" 159 7 19453 34.95597484 1 0.315095991 0.287405388 GOTERM_BP_DIRECT GO:0003007~heart morphogenesis 3 1.875 0.055866225 "GAA, PTK2, VEGFA" 159 47 19453 7.809313529 1 0.316536641 0.288719434 GOTERM_BP_DIRECT GO:0071364~cellular response to epidermal growth factor stimulus 3 1.875 0.057992639 "ERBB2, AKT1, EGFR" 159 48 19453 7.646619497 1 0.327904546 0.299088328 GOTERM_BP_DIRECT GO:0042130~negative regulation of T cell proliferation 3 1.875 0.060146836 "ARG1, PLA2G2A, IDO1" 159 49 19453 7.490566038 1 0.338682495 0.308919112 GOTERM_BP_DIRECT GO:0030900~forebrain development 3 1.875 0.060146836 "APP, SRC, SSTR2" 159 49 19453 7.490566038 1 0.338682495 0.308919112 GOTERM_BP_DIRECT GO:0014823~response to activity 3 1.875 0.062328234 "MMP2, CDK1, PPARD" 159 50 19453 7.340754717 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0050918~positive chemotaxis 3 1.875 0.062328234 "MIF, MET, VEGFA" 159 50 19453 7.340754717 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0042789~mRNA transcription from RNA polymerase II promoter 3 1.875 0.062328234 "THRB, STAT3, PPARG" 159 50 19453 7.340754717 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0010544~negative regulation of platelet activation 2 1.25 0.063170735 "PDGFRA, F2" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:2000272~negative regulation of receptor activity 2 1.25 0.063170735 "PPARG, PPARA" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0038003~opioid receptor signaling pathway 2 1.25 0.063170735 "SIGMAR1, OPRM1" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0010760~negative regulation of macrophage chemotaxis 2 1.25 0.063170735 "MIF, CYP19A1" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0071447~cellular response to hydroperoxide 2 1.25 0.063170735 "DAPK1, PRKCD" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0010742~macrophage derived foam cell differentiation 2 1.25 0.063170735 "EP300, PPARG" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0060336~negative regulation of interferon-gamma-mediated signaling pathway 2 1.25 0.063170735 "ARG1, PPARG" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0002438~acute inflammatory response to antigenic stimulus 2 1.25 0.063170735 "OPRM1, ELANE" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0060736~prostate gland growth 2 1.25 0.063170735 "AR, CYP19A1" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0061044~negative regulation of vascular wound healing 2 1.25 0.063170735 "ALOX5, SERPINE1" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0007197~adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway 2 1.25 0.063170735 "CHRM3, OPRM1" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0007172~signal complex assembly 2 1.25 0.063170735 "SRC, PTK2" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:1903426~regulation of reactive oxygen species biosynthetic process 2 1.25 0.063170735 "ALOX5, SNCA" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0034983~peptidyl-lysine deacetylation 2 1.25 0.063170735 "HDAC4, HDAC9" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0060740~prostate gland epithelium morphogenesis 2 1.25 0.063170735 "AR, MMP2" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0038134~ERBB2-EGFR signaling pathway 2 1.25 0.063170735 "ERBB2, EGFR" 159 8 19453 30.58647799 1 0.342300155 0.312218852 GOTERM_BP_DIRECT GO:0031623~receptor internalization 3 1.875 0.064536253 "ACHE, SYK, SNCA" 159 51 19453 7.19681835 1 0.349006944 0.318336249 GOTERM_BP_DIRECT GO:0030336~negative regulation of cell migration 5 3.125 0.065323965 "HDAC1, SERPINE1, CYP1B1, MIF, DRD2" 159 186 19453 3.288868601 1 0.352568674 0.321584975 GOTERM_BP_DIRECT GO:0043280~positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 3 1.875 0.066770324 "APP, SYK, DAPK1" 159 52 19453 7.058417997 1 0.359664211 0.328056957 GOTERM_BP_DIRECT GO:0043434~response to peptide hormone 3 1.875 0.069029885 "STAT3, BRAF, TRPV1" 159 53 19453 6.925240299 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0051496~positive regulation of stress fiber assembly 3 1.875 0.069029885 "BRAF, TACR1, TGFBR1" 159 53 19453 6.925240299 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0001837~epithelial to mesenchymal transition 3 1.875 0.069029885 "GSK3B, TGFBR1, FGFR1" 159 53 19453 6.925240299 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0010468~regulation of gene expression 6 3.75 0.069587451 "APP, CDK6, CYP1A2, CDK2, AHR, TGFBR1" 159 270 19453 2.718798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0030198~extracellular matrix organization 5 3.125 0.069676528 "PDGFRA, APP, MMP1, MMP2, MMP9" 159 190 19453 3.219629262 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0001542~ovulation from ovarian follicle 2 1.25 0.070782925 "MMP2, PGR" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0034351~negative regulation of glial cell apoptotic process 2 1.25 0.070782925 "PRKCD, PRKCA" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0019371~cyclooxygenase pathway 2 1.25 0.070782925 "PTGS2, PTGS1" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0035095~behavioral response to nicotine 2 1.25 0.070782925 "CHRNA3, PPARA" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0051248~negative regulation of protein metabolic process 2 1.25 0.070782925 "HSP90AB1, MIF" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0034121~regulation of toll-like receptor signaling pathway 2 1.25 0.070782925 "APP, ESR1" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0051128~regulation of cellular component organization 2 1.25 0.070782925 "GSK3B, PTK2" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0060982~coronary artery morphogenesis 2 1.25 0.070782925 "TGFBR1, VEGFA" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:1902949~positive regulation of tau-protein kinase activity 2 1.25 0.070782925 "APP, HSP90AB1" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:1990416~cellular response to brain-derived neurotrophic factor stimulus 2 1.25 0.070782925 "NTRK2, MAPT" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0008354~germ cell migration 2 1.25 0.070782925 "KIT, TGFBR1" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0061298~retina vasculature development in camera-type eye 2 1.25 0.070782925 "PDGFRB, PDGFRA" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0032287~peripheral nervous system myelin maintenance 2 1.25 0.070782925 "AKT1, PLEC" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0061042~vascular wound healing 2 1.25 0.070782925 "KDR, VEGFA" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0071476~cellular hypotonic response 2 1.25 0.070782925 "TSPO, MYLK" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0010907~positive regulation of glucose metabolic process 2 1.25 0.070782925 "SRC, AKT1" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0072540~T-helper 17 cell lineage commitment 2 1.25 0.070782925 "STAT3, JAK1" 159 9 19453 27.18798043 1 0.365421866 0.33330863 GOTERM_BP_DIRECT GO:0007519~skeletal muscle tissue development 3 1.875 0.071314379 "CDK5, EP300, MAPK14" 159 54 19453 6.796995108 1 0.366089416 0.333917516 GOTERM_BP_DIRECT GO:0050877~neurological system process 3 1.875 0.071314379 "GABRA2, CHRNA3, HTR3A" 159 54 19453 6.796995108 1 0.366089416 0.333917516 GOTERM_BP_DIRECT GO:0010951~negative regulation of endopeptidase activity 3 1.875 0.071314379 "SERPINE1, AKT1, GAPDH" 159 54 19453 6.796995108 1 0.366089416 0.333917516 GOTERM_BP_DIRECT GO:0035019~somatic stem cell population maintenance 3 1.875 0.07362326 "STAT3, KIT, BRAF" 159 55 19453 6.673413379 1 0.376526445 0.34343734 GOTERM_BP_DIRECT GO:0045786~negative regulation of cell cycle 3 1.875 0.07362326 "CDK6, CDK5, PTGS2" 159 55 19453 6.673413379 1 0.376526445 0.34343734 GOTERM_BP_DIRECT GO:2000300~regulation of synaptic vesicle exocytosis 3 1.875 0.075955985 "GSK3B, HTR2A, DRD2" 159 56 19453 6.554245283 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0008202~steroid metabolic process 3 1.875 0.075955985 "CYP1A1, TSPO, CYP1B1" 159 56 19453 6.554245283 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0006260~DNA replication 4 2.5 0.077300828 "POLA1, CDK2, CDK1, TOP1" 159 122 19453 4.011341375 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0032259~methylation 4 2.5 0.077300828 "TPMT, CYP1A2, COMT, TYMS" 159 122 19453 4.011341375 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0001553~luteinization 2 1.25 0.07833365 "PDGFRA, MMP2" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0007252~I-kappaB phosphorylation 2 1.25 0.07833365 "TLR9, TLR4" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0007260~tyrosine phosphorylation of STAT protein 2 1.25 0.07833365 "JAK3, JAK1" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0045124~regulation of bone resorption 2 1.25 0.07833365 "CSF1R, SRC" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0070234~positive regulation of T cell apoptotic process 2 1.25 0.07833365 "P2RX7, IDO1" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0033197~response to vitamin E 2 1.25 0.07833365 "CCND1, ARG1" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0010572~positive regulation of platelet activation 2 1.25 0.07833365 "PLA2G4A, TLR4" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT "GO:0051967~negative regulation of synaptic transmission, glutamatergic" 2 1.25 0.07833365 "HTR2A, DRD2" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0032872~regulation of stress-activated MAPK cascade 2 1.25 0.07833365 "MAP2K1, MAPK1" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0031666~positive regulation of lipopolysaccharide-mediated signaling pathway 2 1.25 0.07833365 "PRKCA, MIF" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0001945~lymph vessel development 2 1.25 0.07833365 "SYK, KDR" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0060259~regulation of feeding behavior 2 1.25 0.07833365 "CNR1, STAT3" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0032886~regulation of microtubule-based process 2 1.25 0.07833365 "GSK3B, ERBB2" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:2000048~negative regulation of cell-cell adhesion mediated by cadherin 2 1.25 0.07833365 "PLG, VEGFA" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0071287~cellular response to manganese ion 2 1.25 0.07833365 "APP, HSPA5" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0033629~negative regulation of cell adhesion mediated by integrin 2 1.25 0.07833365 "SERPINE1, CYP1B1" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0030432~peristalsis 2 1.25 0.07833365 "SSTR2, DRD2" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0051093~negative regulation of developmental process 2 1.25 0.07833365 "GSK3B, KIT" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0033598~mammary gland epithelial cell proliferation 2 1.25 0.07833365 "CCND1, MAPK1" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0032060~bleb assembly 2 1.25 0.07833365 "P2RX7, MYLK" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0048149~behavioral response to ethanol 2 1.25 0.07833365 "OPRM1, DRD2" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0002467~germinal center formation 2 1.25 0.07833365 "ADAM17, ADA" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0051593~response to folic acid 2 1.25 0.07833365 "BCHE, TYMS" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0051481~negative regulation of cytosolic calcium ion concentration 2 1.25 0.07833365 "OPRM1, DRD2" 159 10 19453 24.46918239 1 0.380656935 0.347204843 GOTERM_BP_DIRECT GO:0048167~regulation of synaptic plasticity 3 1.875 0.083091928 "ACE, CDK5, MAPT" 159 59 19453 6.220978574 1 0.403062266 0.367641195 GOTERM_BP_DIRECT GO:0031175~neuron projection development 4 2.5 0.083300042 "GSK3B, APP, CDK5, MAPT" 159 126 19453 3.883997205 1 0.403355347 0.367908521 GOTERM_BP_DIRECT GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling 5 3.125 0.085316355 "IKBKB, PARP1, TLR9, GAPDH, TLR4" 159 205 19453 2.984046633 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0051384~response to glucocorticoid 3 1.875 0.085514765 "BCHE, TYMS, PTGS2" 159 60 19453 6.117295597 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0048660~regulation of smooth muscle cell proliferation 2 1.25 0.085823404 "PRKDC, TACR1" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:1903799~negative regulation of production of miRNAs involved in gene silencing by miRNA 2 1.25 0.085823404 "TERT, ESR1" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0002446~neutrophil mediated immunity 2 1.25 0.085823404 "ADAM17, ACE" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0051974~negative regulation of telomerase activity 2 1.25 0.085823404 "SRC, PPARG" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0048771~tissue remodeling 2 1.25 0.085823404 "MMP2, PLG" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0070244~negative regulation of thymocyte apoptotic process 2 1.25 0.085823404 "JAK3, ADA" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0071223~cellular response to lipoteichoic acid 2 1.25 0.085823404 "MAPK14, TLR4" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0060020~Bergmann glial cell differentiation 2 1.25 0.085823404 "MAP2K1, MAPK1" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0030431~sleep 2 1.25 0.085823404 "HTR2A, SLC29A1" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0035666~TRIF-dependent toll-like receptor signaling pathway 2 1.25 0.085823404 "IKBKB, TLR4" 159 11 19453 22.24471126 1 0.406916172 0.371156421 GOTERM_BP_DIRECT GO:0050808~synapse organization 3 1.875 0.087958847 "APP, MAPT, SNCA" 159 61 19453 6.017012063 1 0.415597942 0.379075237 GOTERM_BP_DIRECT GO:0045785~positive regulation of cell adhesion 3 1.875 0.087958847 "ERBB2, PRKCA, VEGFA" 159 61 19453 6.017012063 1 0.415597942 0.379075237 GOTERM_BP_DIRECT GO:0007584~response to nutrient 3 1.875 0.090423674 "CNR1, CYP1B1, PPARG" 159 62 19453 5.919963481 1 0.426506138 0.389024822 GOTERM_BP_DIRECT GO:0051301~cell division 7 4.375 0.092621468 "CDK6, CCND1, CDK5, CDK2, CDK1, NR3C1, AURKA" 159 383 19453 2.236087164 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0001570~vasculogenesis 3 1.875 0.092908754 "NTRK2, KDR, VEGFA" 159 63 19453 5.825995807 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0042110~T cell activation 3 1.875 0.092908754 "DPP4, ADA, PIK3CG" 159 63 19453 5.825995807 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0097011~cellular response to granulocyte macrophage colony-stimulating factor stimulus 2 1.25 0.093252675 "MAPK1, AKT1" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0006983~ER overload response 2 1.25 0.093252675 "GSK3B, HSPA5" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:2001028~positive regulation of endothelial cell chemotaxis 2 1.25 0.093252675 "MET, VEGFA" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0071493~cellular response to UV-B 2 1.25 0.093252675 "MME, MAPK14" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0055003~cardiac myofibril assembly 2 1.25 0.093252675 "PDGFRB, PDGFRA" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:1903800~positive regulation of production of miRNAs involved in gene silencing by miRNA 2 1.25 0.093252675 "MAP2K1, EGFR" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:2000343~positive regulation of chemokine (C-X-C motif) ligand 2 production 2 1.25 0.093252675 "MIF, TLR4" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:2001020~regulation of response to DNA damage stimulus 2 1.25 0.093252675 "MAPT, MCL1" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0065008~regulation of biological quality 2 1.25 0.093252675 "SLC29A1, PTK2" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0043030~regulation of macrophage activation 2 1.25 0.093252675 "MIF, SNCA" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0071679~commissural neuron axon guidance 2 1.25 0.093252675 "ADAM17, VEGFA" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0032308~positive regulation of prostaglandin secretion 2 1.25 0.093252675 "P2RX7, PLA2G4A" 159 12 19453 20.39098532 1 0.428742519 0.391064671 GOTERM_BP_DIRECT GO:0007249~I-kappaB kinase/NF-kappaB signaling 3 1.875 0.0954136 "IKBKB, TLR9, AKT1" 159 64 19453 5.734964623 1 0.437940404 0.399454246 GOTERM_BP_DIRECT GO:0001501~skeletal system development 4 2.5 0.095873461 "HDAC4, MMP9, TGFBR1, FGFR1" 159 134 19453 3.652116775 1 0.439312787 0.400706024