Supplementary Table S7: Results of the molecular function category terms from GO enrichment analysis Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_DIRECT GO:0004712~protein serine/threonine/tyrosine kinase activity 37 23.125 2.12E-25 RET, CAMK2B, CSF1R, GSK3B, FLT1, FLT3, PRKDC, SRC, EGFR, PIK3CG, AURKA, IKBKB, ERBB2, KDR, AKT1, MAPK1, JAK3, JAK1, PDGFRB, PDGFRA, NTRK2, MAP2K1, SYK, CSNK2A1, DAPK1, PRKCD, DYRK1A, PRKCA, MAPK14, PTK2, CDK6, CDK5, KIT, CDK2, CDK1, MET, FGFR1 160 444 18967 9.878645833 1.41E-22 1.41E-22 1.24E-22 GOTERM_MF_DIRECT GO:0004672~protein kinase activity 29 18.125 1.15E-18 RET, CAMK2B, GSK3B, PRKDC, SRC, EGFR, PIK3CG, AURKA, MYLK, IKBKB, CCND1, ERBB2, AKT1, PDGFRA, MAP2K1, SYK, CSNK2A1, DAPK1, PRKCD, DYRK1A, PRKCA, BRAF, MAPK14, TGFBR1, PTK2, CDK5, CDK2, CDK1, MET 160 382 18967 8.999394634 7.68E-16 3.84E-16 3.37E-16 GOTERM_MF_DIRECT GO:0004713~protein tyrosine kinase activity 19 11.875 3.03E-18 PDGFRB, RET, CSF1R, MAP2K1, FLT1, SYK, FLT3, SRC, DYRK1A, BRAF, EGFR, PTK2, KIT, ERBB2, KDR, JAK3, MET, JAK1, FGFR1 160 114 18967 19.75729167 2.02E-15 6.72E-16 5.89E-16 GOTERM_MF_DIRECT GO:0005524~ATP binding 51 31.875 1.19E-17 RET, GSK3B, FLT1, HSP90AB1, FLT3, PIK3CG, MYLK, IKBKB, KDR, AKT1, TK1, JAK3, JAK1, PDGFRB, PDGFRA, ABCC1, MAP2K1, CSNK2A1, SYK, DAPK1, PRKCD, DYRK1A, PRKCA, TGFBR1, KIT, TOP1, MET, CFTR, ABCG2, CAMK2B, CSF1R, ABCB1, SRC, PRKDC, EGFR, AURKA, ERBB2, MAPK1, NTRK2, HSPA8, HSPA5, BRAF, TRPV1, MAPK14, PTK2, P2RX7, CDK6, CDK5, CDK2, CDK1, FGFR1 160 1539 18967 3.92835039 7.91E-15 1.98E-15 1.73E-15 GOTERM_MF_DIRECT GO:0019899~enzyme binding 28 17.5 1.65E-17 APP, THRB, HSP90AB1, PRKDC, HDAC1, SRC, PLG, PTGS2, EGFR, CCND1, AKT1, PDGFRB, BCHE, HSPA8, JUN, PARP1, HSPA5, PRKCD, PRKCA, MAPK14, ESR1, AR, CYP1A2, CYP1A1, PPARG, PGR, MAPT, CFTR 160 386 18967 8.599028497 1.10E-14 2.20E-15 1.93E-15 GOTERM_MF_DIRECT GO:0042802~identical protein binding 50 31.25 9.15E-15 CDA, APP, HSP90AB1, HTR2A, NR3C1, PIK3CG, IKBKB, PNP, KDR, AKT1, TK1, KCNH2, PARP1, CSNK2A1, DAPK1, ARG1, SIGMAR1, DYRK1A, MIF, MMP9, PPARG, PGR, MAPT, MET, GAPDH, TLR4, ABCG2, HDAC4, CAMK2B, SLC22A6, MAOB, EGFR, DPP4, TTR, TERT, CNR1, ERBB2, MAPK1, DRD2, SNCA, BCHE, JUN, STAT3, BRAF, TRPV1, TYR, ESR1, VEGFA, P2RX7, FGFR1 160 1736 18967 3.414278514 6.06E-12 1.02E-12 8.91E-13 GOTERM_MF_DIRECT GO:0004714~transmembrane receptor protein tyrosine kinase activity 13 8.125 2.01E-14 PDGFRB, RET, PDGFRA, NTRK2, CSF1R, FLT1, FLT3, EGFR, KIT, ERBB2, KDR, MET, FGFR1 160 54 18967 28.53831019 1.34E-11 1.91E-12 1.68E-12 GOTERM_MF_DIRECT GO:0042803~protein homodimerization activity 31 19.375 7.94E-13 CAMK2B, CDA, CSF1R, APP, ACHE, HSP90AB1, ODC1, AHR, TYMS, PTGS2, TYMP, DPP4, IKBKB, TERT, AKT1, XDH, MCL1, KCNH2, PDGFRA, NTRK2, PARP1, MME, NOS2, EPHX2, STAT3, TYR, VEGFA, KIT, TLR9, FGFR1, ABCG2 160 749 18967 4.906350134 5.29E-10 6.61E-11 5.79E-11 GOTERM_MF_DIRECT GO:0004674~protein serine/threonine kinase activity 22 13.75 2.20E-11 CAMK2B, GSK3B, MAP2K1, SYK, CSNK2A1, DAPK1, PRKDC, PRKCD, DYRK1A, BRAF, PRKCA, MAPK14, TGFBR1, PIK3CG, AURKA, IKBKB, CDK5, CDK2, CDK1, AKT1, MAPK1, TOP1 160 400 18967 6.51990625 1.47E-08 1.50E-09 1.31E-09 GOTERM_MF_DIRECT GO:0004879~RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 11 6.875 2.25E-11 AR, THRB, NR1I3, STAT3, PGR, PPARG, AHR, PPARA, NR3C1, ESR1, PPARD 160 54 18967 24.14780093 1.50E-08 1.50E-09 1.31E-09 GOTERM_MF_DIRECT GO:0001223~transcription coactivator binding 10 6.25 2.06E-10 AR, CREBBP, THRB, TERT, EP300, PGR, AHR, PPARA, ESR1, PPARD 160 48 18967 24.69661458 1.38E-07 1.25E-08 1.10E-08 GOTERM_MF_DIRECT GO:0016301~kinase activity 16 10 1.12E-09 RET, NTRK2, GSK3B, SYK, CSNK2A1, DAPK1, PRKDC, DYRK1A, PRKCA, EGFR, PIK3CG, MYLK, CDK5, ERBB2, CDK1, AKT1 160 232 18967 8.175431034 7.43E-07 6.19E-08 5.43E-08 GOTERM_MF_DIRECT GO:0019838~growth factor binding 9 5.625 1.25E-09 PDGFRB, PDGFRA, CSF1R, FLT1, FLT3, ERBB2, KIT, KDR, TGFBR1 160 40 18967 26.67234375 8.33E-07 6.41E-08 5.62E-08 GOTERM_MF_DIRECT GO:0005515~protein binding 140 87.5 1.62E-09 APP, CHRM3, CDA, TPMT, SERPINE1, AHR, COMT, NR3C1, MPO, MYLK, PNP, CCND1, KDR, CYP1B1, AKT1, EP300, PDGFRB, KCNH2, PDGFRA, MAP2K1, CSNK2A1, DAPK1, PRKCD, DYRK1A, PRKCA, MIF, AR, ALDH3A1, ADAM17, PGR, CFTR, ABCG2, CSF1R, CHRNA3, SLC22A6, ABCB1, MAOB, MAOA, PRKDC, SLC5A1, DPP4, TERT, DRD2, ELANE, MCL1, HSPA8, MGAM, CREBBP, JUN, HSPA5, EPHX1, HTR1A, BRAF, TRPV1, TYR, ESR1, PTK2, POLA1, CDK6, CDK5, CYP1A2, CDK2, CYP1A1, CDK1, SHBG, ADA, FGFR1, RET, ACHE, GSK3B, FLT1, THRB, HSP90AB1, FLT3, AKR1B1, HTR2A, PIK3CG, IKBKB, TSPO, TK1, JAK3, JAK1, CTSB, PARP1, SYK, MME, ARG1, MMP2, SIGMAR1, HTR3A, OPRM1, TACR1, SSTR2, F2, F3, MMP9, TGFBR1, KIT, PPARG, MAPT, TOP1, PPARA, GAPDH, MET, TLR4, PPARD, PLEC, HDAC4, CAMK2B, SRC, HDAC1, NR1I3, ODC1, PLG, HMGCR, HDAC8, PTGS2, HDAC9, EGFR, TYMP, PTGS1, AURKA, TTR, CNR1, ALOX5, ERBB2, MAPK1, XDH, SNCA, GABRA2, NTRK2, BCHE, NOS2, STAT3, MAPK14, DHODH, VEGFA, P2RX7, FABP2, APEX1 160 12657 18967 1.311221063 1.08E-06 7.71E-08 6.76E-08 GOTERM_MF_DIRECT GO:0061629~RNA polymerase II sequence-specific DNA binding transcription factor binding 13 8.125 5.98E-08 HDAC4, GSK3B, CREBBP, JUN, PARP1, PRKDC, HDAC1, STAT3, AHR, HDAC9, AR, EP300, PPARA 160 187 18967 8.241009358 3.98E-05 2.66E-06 2.33E-06 GOTERM_MF_DIRECT GO:0019903~protein phosphatase binding 10 6.25 7.10E-08 CSF1R, ERBB2, STAT3, PPARG, MAPK14, JAK3, MET, PTK2, EGFR, JAK1 160 91 18967 13.02678571 4.73E-05 2.95E-06 2.59E-06 GOTERM_MF_DIRECT GO:0051879~Hsp90 protein binding 8 5 7.53E-08 CSNK2A1, CDK5, CYP1A1, KDR, AHR, MAPT, NR3C1, HDAC8 160 44 18967 21.55340909 5.01E-05 2.95E-06 2.59E-06 GOTERM_MF_DIRECT GO:0008270~zinc ion binding 25 15.625 3.88E-07 HDAC4, CDA, THRB, NR1I3, NR3C1, ANPEP, EP300, TK1, SNCA, CREBBP, ACE, PARP1, MME, MMP1, MMP2, PRKCA, MMP9, ESR1, POLA1, AR, PPARG, PGR, PPARA, ADA, PPARD 160 888 18967 3.337380349 2.58E-04 1.43E-05 1.26E-05 GOTERM_MF_DIRECT GO:0020037~heme binding 11 6.875 7.47E-07 NOS2, MB, SRC, CYP1A2, CYP1A1, CYP1B1, PTGS2, MPO, CYP19A1, IDO1, PTGS1 160 155 18967 8.412782258 4.97E-04 2.62E-05 2.29E-05 GOTERM_MF_DIRECT GO:0019901~protein kinase binding 18 11.25 1.87E-06 PDGFRB, HDAC4, GSK3B, HSP90AB1, SYK, PARP1, PRKCD, STAT3, NR3C1, ESR1, PTK2, AURKA, IKBKB, POLA1, CCND1, CDK5, AKT1, MAPT 160 521 18967 4.09556142 0.00124564 6.23E-05 5.46E-05 GOTERM_MF_DIRECT GO:0005102~receptor binding 16 10 2.07E-06 PDGFRB, APP, SYK, SRC, STAT3, SERPINE1, PLG, F2, TGFBR1, PTK2, P2RX7, DPP4, AR, PGR, GUSB, TLR4 160 412 18967 4.603640777 0.001376089 6.56E-05 5.75E-05 GOTERM_MF_DIRECT GO:0004715~non-membrane spanning protein tyrosine kinase activity 7 4.375 2.24E-06 SYK, SRC, PRKCD, DYRK1A, JAK3, PTK2, JAK1 160 46 18967 18.0392663 0.001491753 6.79E-05 5.95E-05 GOTERM_MF_DIRECT GO:0004175~endopeptidase activity 8 5 4.45E-06 ADAM17, ACE, MME, MMP1, MMP2, PLG, MMP9, ELANE 160 79 18967 12.00443038 0.002961953 1.29E-04 1.13E-04 GOTERM_MF_DIRECT GO:0002020~protease binding 9 5.625 4.97E-06 DPP4, NTRK2, GSK3B, KIT, SERPINE1, PLG, MIF, F3, ELANE 160 113 18967 9.441537611 0.003301409 1.38E-04 1.21E-04 GOTERM_MF_DIRECT GO:0009055~electron carrier activity 7 4.375 2.45E-05 MAOB, ALDH2, CYP1A2, GSR, AKR1B1, CYP19A1, IDO1 160 69 18967 12.02617754 0.016168916 6.52E-04 5.72E-04 GOTERM_MF_DIRECT GO:0048156~tau protein binding 6 3.75 2.89E-05 GSK3B, HSP90AB1, CDK5, DYRK1A, EP300, SNCA 160 43 18967 16.54098837 0.01908276 7.41E-04 6.50E-04 GOTERM_MF_DIRECT GO:0005021~vascular endothelial growth factor-activated receptor activity 4 2.5 3.14E-05 PDGFRA, FLT1, FLT3, KDR 160 8 18967 59.271875 0.020688806 7.47E-04 6.55E-04 GOTERM_MF_DIRECT GO:0030235~nitric-oxide synthase regulator activity 4 2.5 3.14E-05 HSP90AB1, AKT1, ESR1, EGFR 160 8 18967 59.271875 0.020688806 7.47E-04 6.55E-04 GOTERM_MF_DIRECT GO:0031625~ubiquitin protein ligase binding 12 7.5 7.27E-05 KCNH2, HSPA8, GSK3B, JUN, ABCB1, HSP90AB1, HSPA5, PARP1, EGFR, TGFBR1, JAK1, AURKA 160 315 18967 4.515952381 0.04725614 0.001669222 0.001463702 GOTERM_MF_DIRECT GO:0034056~estrogen response element binding 4 2.5 9.08E-05 AR, PGR, NR3C1, ESR1 160 11 18967 43.10681818 0.05867681 0.002015533 0.001767375 GOTERM_MF_DIRECT GO:0005496~steroid binding 5 3.125 1.10E-04 AR, PGR, NR3C1, SHBG, ESR1 160 30 18967 19.75729167 0.070612692 0.002362119 0.002071288 GOTERM_MF_DIRECT GO:0033558~protein deacetylase activity 4 2.5 1.20E-04 HDAC4, HDAC1, HDAC8, HDAC9 160 12 18967 39.51458333 0.077003873 0.002428043 0.002129095 GOTERM_MF_DIRECT GO:0032041~NAD-dependent histone deacetylase activity (H3-K14 specific) 4 2.5 1.20E-04 HDAC4, HDAC1, HDAC8, HDAC9 160 12 18967 39.51458333 0.077003873 0.002428043 0.002129095 GOTERM_MF_DIRECT GO:0008353~RNA polymerase II carboxy-terminal domain kinase activity 4 2.5 1.55E-04 CDK6, DYRK1A, CDK1, MAPK1 160 13 18967 36.475 0.098351582 0.002994594 0.002625891 GOTERM_MF_DIRECT GO:0016491~oxidoreductase activity 10 6.25 1.57E-04 ALDH3A1, MAOB, NOS2, MAOA, APEX1, CYP1A2, CYP1A1, TYR, XDH, SNCA 160 233 18967 5.087714592 0.099512549 0.002994594 0.002625891 GOTERM_MF_DIRECT GO:0016702~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4 2.5 1.97E-04 ALOX5, PTGS2, IDO1, PTGS1 160 14 18967 33.86964286 0.122746292 0.003637393 0.003189546 GOTERM_MF_DIRECT GO:0051059~NF-kappaB binding 5 3.125 2.27E-04 GSK3B, HDAC1, APEX1, EP300, PPARD 160 36 18967 16.46440972 0.140475128 0.004090765 0.003587097 GOTERM_MF_DIRECT GO:0008233~peptidase activity 7 4.375 2.56E-04 APP, ADAM17, ACE, MMP1, MMP9, ELANE, CTSB 160 105 18967 7.902916667 0.157051733 0.004495468 0.003941972 GOTERM_MF_DIRECT GO:0042277~peptide binding 6 3.75 2.65E-04 HSP90AB1, MME, ANPEP, PPARG, OPRM1, SSTR2 160 68 18967 10.45974265 0.161654879 0.004520566 0.00396398 GOTERM_MF_DIRECT GO:0097110~scaffold protein binding 6 3.75 2.83E-04 KCNH2, IKBKB, MAP2K1, SYK, SRC, BRAF 160 69 18967 10.30815217 0.172071886 0.004720055 0.004138907 GOTERM_MF_DIRECT GO:0051087~chaperone binding 7 4.375 3.30E-04 HSPA8, APP, TERT, HSPA5, PLG, MAPT, CFTR 160 110 18967 7.543693182 0.197255928 0.005358124 0.004698415 GOTERM_MF_DIRECT GO:0004708~MAP kinase kinase activity 4 2.5 5.08E-04 MAP2K1, MAPK1, BRAF, MAPK14 160 19 18967 24.95657895 0.28688019 0.008048096 0.007057189 GOTERM_MF_DIRECT GO:0004407~histone deacetylase activity 4 2.5 5.93E-04 HDAC4, HDAC1, HDAC8, HDAC9 160 20 18967 23.70875 0.326555213 0.009191441 0.008059762 GOTERM_MF_DIRECT GO:0005216~ion channel activity 5 3.125 6.41E-04 P2RX7, GABRA2, KCNH2, HTR3A, TRPV1 160 47 18967 12.61103723 0.347415454 0.009697224 0.008503271 GOTERM_MF_DIRECT GO:0030594~neurotransmitter receptor activity 6 3.75 6.67E-04 GABRA2, CHRM3, CHRNA3, HTR1A, HTR3A, HTR2A 160 83 18967 8.569427711 0.358634364 0.009733084 0.008534716 GOTERM_MF_DIRECT GO:0005497~androgen binding 3 1.875 6.87E-04 AR, TSPO, SHBG 160 5 18967 71.12625 0.36720713 0.009733084 0.008534716 GOTERM_MF_DIRECT GO:0038085~vascular endothelial growth factor binding 3 1.875 6.87E-04 PDGFRB, PDGFRA, KDR 160 5 18967 71.12625 0.36720713 0.009733084 0.008534716 GOTERM_MF_DIRECT GO:0003707~steroid hormone receptor activity 4 2.5 9.05E-04 PGR, PPARA, ESR1, PPARD 160 23 18967 20.61630435 0.452860313 0.012557879 0.011011714 GOTERM_MF_DIRECT GO:0003682~chromatin binding 13 8.125 0.001024458 APP, CREBBP, JUN, PARP1, MPO, ESR1, EGFR, POLA1, AR, CDK1, EP300, PPARG, TOP1 160 498 18967 3.094515562 0.494717936 0.01339484 0.011745626 GOTERM_MF_DIRECT GO:0004558~alpha-1,4-glucosidase activity 3 1.875 0.001024629 MGAM, GAA, SI 160 6 18967 59.271875 0.494775663 0.01339484 0.011745626 GOTERM_MF_DIRECT GO:0004252~serine-type endopeptidase activity 8 5 0.001025731 DPP4, MMP1, MMP2, PLG, F2, F3, MMP9, ELANE 160 187 18967 5.071390374 0.495146735 0.01339484 0.011745626 GOTERM_MF_DIRECT GO:0042910~xenobiotic transporter activity 4 2.5 0.001304485 ABCC1, SLC22A6, ABCB1, ABCG2 160 26 18967 18.2375 0.580777881 0.016707447 0.014650374 GOTERM_MF_DIRECT GO:0016787~hydrolase activity 9 5.625 0.001522416 HDAC4, ACHE, ABCC1, ALOX5, EPHX2, EPHX1, HDAC8, HDAC9, CFTR 160 258 18967 4.135247093 0.637489328 0.019130731 0.016775296 GOTERM_MF_DIRECT GO:0004553~hydrolase activity, hydrolyzing O-glycosyl compounds 4 2.5 0.001623612 MGAM, GAA, SI, GUSB 160 28 18967 16.93482143 0.661152328 0.020024553 0.017559067 GOTERM_MF_DIRECT GO:0004693~cyclin-dependent protein serine/threonine kinase activity 4 2.5 0.001799885 CDK6, CDK5, CDK2, CDK1 160 29 18967 16.35086207 0.698746689 0.021794977 0.019111511 GOTERM_MF_DIRECT GO:0101020~estrogen 16-alpha-hydroxylase activity 3 1.875 0.001891649 CYP1A2, CYP1A1, CYP1B1 160 8 18967 44.45390625 0.71663844 0.022497116 0.019727201 GOTERM_MF_DIRECT GO:0005516~calmodulin binding 8 5 0.001993388 CAMK2B, ACE, NOS2, DAPK1, AKT1, TRPV1, ESR1, MYLK 160 210 18967 4.515952381 0.735237249 0.023291161 0.02042348 GOTERM_MF_DIRECT GO:0046875~ephrin receptor binding 4 2.5 0.002187182 APP, CDK5, SRC, PIK3CG 160 31 18967 15.29596774 0.767358927 0.025114882 0.022022659 GOTERM_MF_DIRECT GO:0005178~integrin binding 7 4.375 0.002318793 APP, ADAM17, SYK, SRC, KDR, PRKCA, PTK2 160 160 18967 5.186289062 0.786924638 0.026174849 0.02295212 GOTERM_MF_DIRECT GO:0043565~sequence-specific DNA binding 10 6.25 0.002519221 AR, THRB, NR1I3, PGR, PPARG, MAPT, PPARA, NR3C1, ESR1, PPARD 160 344 18967 3.446039244 0.813610783 0.027426236 0.024049432 GOTERM_MF_DIRECT GO:0004222~metalloendopeptidase activity 6 3.75 0.002537312 ADAM17, ACE, MME, MMP1, MMP2, MMP9 160 112 18967 6.350558036 0.815848661 0.027426236 0.024049432 GOTERM_MF_DIRECT GO:0050660~flavin adenine dinucleotide binding 5 3.125 0.002553193 MAOB, NOS2, MAOA, GSR, XDH 160 68 18967 8.716452206 0.81779104 0.027426236 0.024049432 GOTERM_MF_DIRECT GO:0070330~aromatase activity 4 2.5 0.002622483 CYP1A2, CYP1A1, CYP1B1, CYP19A1 160 33 18967 14.36893939 0.826029189 0.02772339 0.024309999 GOTERM_MF_DIRECT GO:0008237~metallopeptidase activity 5 3.125 0.002987762 ADAM17, ACE, ANPEP, MMP2, MMP9 160 71 18967 8.348151408 0.863690592 0.031091397 0.027263327 GOTERM_MF_DIRECT GO:0003690~double-stranded DNA binding 6 3.75 0.003179418 JUN, PRKDC, PPARG, MAPT, TOP1, EGFR 160 118 18967 6.027648305 0.880072259 0.032576808 0.02856585 GOTERM_MF_DIRECT GO:0002039~p53 binding 5 3.125 0.003303997 GSK3B, CREBBP, CDK5, HDAC1, EP300 160 73 18967 8.119434932 0.889650788 0.033340335 0.029235369 GOTERM_MF_DIRECT GO:0043621~protein self-association 5 3.125 0.003470345 ACHE, FLT3, DYRK1A, PPARG, PLEC 160 74 18967 8.009712838 0.901260418 0.034496264 0.030248976 GOTERM_MF_DIRECT GO:0042166~acetylcholine binding 3 1.875 0.003654838 ACHE, CHRM3, CHRNA3 160 11 18967 32.33011364 0.912715381 0.035795912 0.031388607 GOTERM_MF_DIRECT GO:0003677~DNA binding 22 13.75 0.003981321 HDAC4, APP, JUN, THRB, PARP1, NR1I3, STAT3, AHR, NR3C1, ESR1, POLA1, AR, TERT, APEX1, EP300, MAPK1, PGR, PPARG, MAPT, TOP1, PPARA, PPARD 160 1337 18967 1.950607704 0.929831263 0.038019449 0.033338376 GOTERM_MF_DIRECT GO:0000976~transcription regulatory region sequence-specific DNA binding 8 5 0.003996038 KCNH2, HDAC4, AR, JUN, STAT3, PPARG, AHR, SNCA 160 238 18967 3.984663866 0.930518385 0.038019449 0.033338376 GOTERM_MF_DIRECT GO:0001618~virus receptor activity 5 3.125 0.004589244 DPP4, ANPEP, CDK1, HTR2A, EGFR 160 80 18967 7.408984375 0.95327478 0.043048399 0.037748146 GOTERM_MF_DIRECT GO:0042169~SH2 domain binding 4 2.5 0.004879441 SYK, SRC, KIT, PTK2 160 41 18967 11.5652439 0.961521751 0.045134832 0.039577691 GOTERM_MF_DIRECT GO:0051378~serotonin binding 3 1.875 0.005126526 HTR1A, HTR3A, HTR2A 160 13 18967 27.35625 0.967387128 0.046770774 0.041012211 GOTERM_MF_DIRECT GO:0030331~estrogen receptor binding 4 2.5 0.005222836 PARP1, SRC, PPARG, ESR1 160 42 18967 11.28988095 0.969423518 0.047005524 0.041218057 GOTERM_MF_DIRECT GO:0019904~protein domain specific binding 8 5 0.00545212 HSPA5, PRKDC, CDK2, PLG, OPRM1, TOP1, PPARA, GUSB 160 252 18967 3.763293651 0.973775116 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0042826~histone deacetylase binding 6 3.75 0.005454308 HDAC4, HSP90AB1, CCND1, PARP1, HDAC1, HDAC9 160 134 18967 5.307929104 0.973813508 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0050661~NADP binding 4 2.5 0.005580428 NOS2, GSR, HMGCR, GAPDH 160 43 18967 11.02732558 0.975934453 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0008022~protein C-terminus binding 7 4.375 0.005674426 MAP2K1, TERT, SRC, ERBB2, EP300, PPARG, OPRM1 160 192 18967 4.321907552 0.977402841 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0031490~chromatin DNA binding 5 3.125 0.005689306 CREBBP, THRB, APEX1, STAT3, EP300 160 85 18967 6.973161765 0.977626932 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0051117~ATPase binding 5 3.125 0.005928601 AR, SRC, PGR, ESR1, EGFR 160 86 18967 6.892078488 0.980940685 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0015562~efflux transmembrane transporter activity 3 1.875 0.005948178 ABCC1, ABCB1, ABCG2 160 14 18967 25.40223214 0.981189035 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0005161~platelet-derived growth factor receptor binding 3 1.875 0.005948178 PDGFRB, PDGFRA, VEGFA 160 14 18967 25.40223214 0.981189035 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0008559~xenobiotic-transporting ATPase activity 3 1.875 0.005948178 ABCC1, ABCB1, ABCG2 160 14 18967 25.40223214 0.981189035 0.047728754 0.041852241 GOTERM_MF_DIRECT GO:0004888~transmembrane signaling receptor activity 7 4.375 0.006873719 GABRA2, ERBB2, TLR9, HTR3A, TRPV1, TLR4, EGFR 160 200 18967 4.14903125 0.989884664 0.054335349 0.047645411 GOTERM_MF_DIRECT GO:0003824~catalytic activity 6 3.75 0.006934692 BCHE, MGAM, GAA, EPHX2, ODC1, DHODH 160 142 18967 5.008890845 0.990289942 0.054335349 0.047645411 GOTERM_MF_DIRECT GO:0042626~ATPase activity, coupled to transmembrane movement of substances 4 2.5 0.007155757 ABCC1, ABCB1, CFTR, ABCG2 160 47 18967 10.08882979 0.99162804 0.055415515 0.048592583 GOTERM_MF_DIRECT GO:0005506~iron ion binding 6 3.75 0.007557705 ALOX5, CYP1A2, CYP1A1, CYP1B1, CYP19A1, XDH 160 145 18967 4.905258621 0.99360698 0.057235998 0.050188924 GOTERM_MF_DIRECT GO:0003714~transcription corepressor activity 7 4.375 0.007562715 HDAC4, CREBBP, CCND1, HDAC1, APEX1, HDAC9, ELANE 160 204 18967 4.067677696 0.993628436 0.057235998 0.050188924 GOTERM_MF_DIRECT GO:0030544~Hsp70 protein binding 4 2.5 0.008969379 CYP1A1, CDK1, HDAC8, SNCA 160 51 18967 9.29754902 0.997522629 0.067119171 0.058855249 GOTERM_MF_DIRECT GO:0034185~apolipoprotein binding 3 1.875 0.010875084 APP, PLG, MAPT 160 19 18967 18.71743421 0.999312519 0.080475622 0.070567212 GOTERM_MF_DIRECT GO:0019900~kinase binding 5 3.125 0.012200375 HSP90AB1, SRC, PRKCD, PLG, EGFR 160 106 18967 5.591686321 0.999718513 0.08929066 0.078296915 GOTERM_MF_DIRECT GO:0044877~macromolecular complex binding 9 5.625 0.012939499 PDGFRA, TTR, CCND1, FLT3, APEX1, BRAF, HTR2A, DRD2, PPARA 160 370 18967 2.883496622 0.999829017 0.093057571 0.081600032 GOTERM_MF_DIRECT GO:0047485~protein N-terminus binding 5 3.125 0.012994526 MAP2K1, CSNK2A1, TERT, PARP1, HDAC1 160 108 18967 5.488136574 0.999835249 0.093057571 0.081600032 GOTERM_MF_DIRECT GO:0016620~oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3 1.875 0.013210056 ALDH3A1, ALDH2, GAPDH 160 21 18967 16.93482143 0.999857551 0.09359465 0.082070984 GOTERM_MF_DIRECT GO:0003700~transcription factor activity, sequence-specific DNA binding 12 7.5 0.014382174 AR, JUN, THRB, NR1I3, STAT3, PGR, PPARG, AHR, PPARA, NR3C1, ESR1, PPARD 160 613 18967 2.320595432 0.99993545 0.100259878 0.087915568 GOTERM_MF_DIRECT GO:0050321~tau-protein kinase activity 3 1.875 0.014451874 GSK3B, CDK5, DYRK1A 160 22 18967 16.16505682 0.99993842 0.100259878 0.087915568 GOTERM_MF_DIRECT GO:0097472~cyclin-dependent protein kinase activity 2 1.25 0.016696126 CDK2, CDK1 160 2 18967 118.54375 0.999986509 0.111196198 0.097505375 GOTERM_MF_DIRECT GO:0004666~prostaglandin-endoperoxide synthase activity 2 1.25 0.016696126 PTGS2, PTGS1 160 2 18967 118.54375 0.999986509 0.111196198 0.097505375 GOTERM_MF_DIRECT GO:0034212~peptide N-acetyltransferase activity 2 1.25 0.016696126 CREBBP, EP300 160 2 18967 118.54375 0.999986509 0.111196198 0.097505375 GOTERM_MF_DIRECT GO:0003990~acetylcholinesterase activity 2 1.25 0.016696126 ACHE, BCHE 160 2 18967 118.54375 0.999986509 0.111196198 0.097505375 GOTERM_MF_DIRECT GO:0016712~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3 1.875 0.017079683 CYP1A2, CYP1B1, CYP19A1 160 24 18967 14.81796875 0.999989596 0.112624446 0.098757772 GOTERM_MF_DIRECT GO:0008201~heparin binding 6 3.75 0.017558036 APP, F2, MPO, ELANE, FGFR1, VEGFA 160 179 18967 3.97353352 0.999992477 0.114643649 0.100528365 GOTERM_MF_DIRECT GO:0070412~R-SMAD binding 3 1.875 0.01846391 JUN, PARP1, PPARG 160 25 18967 14.22525 0.99999593 0.119388003 0.104688579 GOTERM_MF_DIRECT GO:0003684~damaged DNA binding 4 2.5 0.018727847 CREBBP, PARP1, APEX1, EP300 160 67 18967 7.077238806 0.999996598 0.11993025 0.105164063 GOTERM_MF_DIRECT GO:0017025~TBP-class protein binding 3 1.875 0.021368686 AHR, NR3C1, ESR1 160 27 18967 13.17152778 0.999999435 0.135538521 0.118850595 GOTERM_MF_DIRECT GO:0097621~monoamine oxidase activity 2 1.25 0.024940013 MAOB, MAOA 160 3 18967 79.02916667 0.99999995 0.151000441 0.132408795 GOTERM_MF_DIRECT GO:0032450~maltose alpha-glucosidase activity 2 1.25 0.024940013 MGAM, GAA 160 3 18967 79.02916667 0.99999995 0.151000441 0.132408795 GOTERM_MF_DIRECT GO:0099635~voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels 2 1.25 0.024940013 CDK5, CNR1 160 3 18967 79.02916667 0.99999995 0.151000441 0.132408795 GOTERM_MF_DIRECT GO:0001882~nucleoside binding 2 1.25 0.024940013 CDA, PNP 160 3 18967 79.02916667 0.99999995 0.151000441 0.132408795 GOTERM_MF_DIRECT GO:0004104~cholinesterase activity 2 1.25 0.024940013 ACHE, BCHE 160 3 18967 79.02916667 0.99999995 0.151000441 0.132408795 GOTERM_MF_DIRECT GO:0003779~actin binding 8 5 0.025440159 CAMK2B, ACE, DYRK1A, MAPT, PTK2, PLEC, MYLK, SNCA 160 342 18967 2.772953216 0.999999965 0.152640955 0.133847324 GOTERM_MF_DIRECT GO:0004497~monooxygenase activity 4 2.5 0.02876088 CYP1A2, CYP1A1, CYP1B1, CYP19A1 160 79 18967 6.00221519 0.999999996 0.171024518 0.149967445 GOTERM_MF_DIRECT GO:0005230~extracellular ligand-gated ion channel activity 3 1.875 0.02938675 GABRA2, HTR3A, TRPV1 160 32 18967 11.11347656 0.999999998 0.173199783 0.151874884 GOTERM_MF_DIRECT GO:0004993~G-protein coupled serotonin receptor activity 3 1.875 0.032879399 CHRM3, HTR1A, HTR2A 160 34 18967 10.45974265 1 0.183789444 0.161160714 GOTERM_MF_DIRECT GO:0008238~exopeptidase activity 2 1.25 0.033115215 ACE, MME 160 4 18967 59.271875 1 0.183789444 0.161160714 GOTERM_MF_DIRECT GO:0052596~phenethylamine:oxygen oxidoreductase (deaminating) activity 2 1.25 0.033115215 MAOB, MAOA 160 4 18967 59.271875 1 0.183789444 0.161160714 GOTERM_MF_DIRECT GO:0090722~receptor-receptor interaction 2 1.25 0.033115215 HTR1A, FGFR1 160 4 18967 59.271875 1 0.183789444 0.161160714 GOTERM_MF_DIRECT GO:0046943~carboxylic acid transmembrane transporter activity 2 1.25 0.033115215 ABCC1, ABCB1 160 4 18967 59.271875 1 0.183789444 0.161160714 GOTERM_MF_DIRECT GO:0052595~aliphatic-amine oxidase activity 2 1.25 0.033115215 MAOB, MAOA 160 4 18967 59.271875 1 0.183789444 0.161160714 GOTERM_MF_DIRECT GO:0030549~acetylcholine receptor activator activity 2 1.25 0.033115215 APP, CDK5 160 4 18967 59.271875 1 0.183789444 0.161160714 GOTERM_MF_DIRECT GO:0030332~cyclin binding 3 1.875 0.034683746 CDK6, CDK2, CDK1 160 35 18967 10.16089286 1 0.190903922 0.167399235 GOTERM_MF_DIRECT GO:0004601~peroxidase activity 3 1.875 0.038404687 PTGS2, MPO, PTGS1 160 37 18967 9.611655405 1 0.204620174 0.179426699 GOTERM_MF_DIRECT GO:0051287~NAD binding 3 1.875 0.038404687 ALDH2, PARP1, GAPDH 160 37 18967 9.611655405 1 0.204620174 0.179426699 GOTERM_MF_DIRECT GO:0001221~transcription cofactor binding 3 1.875 0.038404687 EP300, PPARG, ESR1 160 37 18967 9.611655405 1 0.204620174 0.179426699 GOTERM_MF_DIRECT GO:0019825~oxygen binding 3 1.875 0.038404687 MB, CYP1A1, CYP19A1 160 37 18967 9.611655405 1 0.204620174 0.179426699 GOTERM_MF_DIRECT GO:0051219~phosphoprotein binding 3 1.875 0.040319793 SRC, TRPV1, SNCA 160 38 18967 9.358717105 1 0.209572923 0.18376965 GOTERM_MF_DIRECT GO:0101021~estrogen 2-hydroxylase activity 2 1.25 0.041222302 CYP1A2, CYP1A1 160 5 18967 47.4175 1 0.209572923 0.18376965 GOTERM_MF_DIRECT GO:0004030~aldehyde dehydrogenase [NAD(P)+] activity 2 1.25 0.041222302 ALDH3A1, ALDH2 160 5 18967 47.4175 1 0.209572923 0.18376965 GOTERM_MF_DIRECT GO:0004301~epoxide hydrolase activity 2 1.25 0.041222302 EPHX2, EPHX1 160 5 18967 47.4175 1 0.209572923 0.18376965 GOTERM_MF_DIRECT GO:0035173~histone kinase activity 2 1.25 0.041222302 CDK2, CDK1 160 5 18967 47.4175 1 0.209572923 0.18376965 GOTERM_MF_DIRECT GO:0043125~ErbB-3 class receptor binding 2 1.25 0.041222302 CDK5, ERBB2 160 5 18967 47.4175 1 0.209572923 0.18376965 GOTERM_MF_DIRECT GO:0008013~beta-catenin binding 4 2.5 0.042253845 GSK3B, AR, EP300, ESR1 160 92 18967 5.154076087 1 0.213189852 0.186941252 GOTERM_MF_DIRECT GO:0042056~chemoattractant activity 3 1.875 0.044255621 APP, MIF, VEGFA 160 40 18967 8.89078125 1 0.219957042 0.192875244 GOTERM_MF_DIRECT GO:0001530~lipopolysaccharide binding 3 1.875 0.044255621 P2RX7, F2, TLR4 160 40 18967 8.89078125 1 0.219957042 0.192875244 GOTERM_MF_DIRECT GO:0008131~primary amine oxidase activity 2 1.25 0.049261836 MAOB, MAOA 160 6 18967 39.51458333 1 0.234345592 0.205492231 GOTERM_MF_DIRECT GO:0051525~NFAT protein binding 2 1.25 0.049261836 MAPK14, PPARA 160 6 18967 39.51458333 1 0.234345592 0.205492231 GOTERM_MF_DIRECT GO:0004985~opioid receptor activity 2 1.25 0.049261836 SIGMAR1, OPRM1 160 6 18967 39.51458333 1 0.234345592 0.205492231 GOTERM_MF_DIRECT GO:0055131~C3HC4-type RING finger domain binding 2 1.25 0.049261836 KCNH2, HSPA8 160 6 18967 39.51458333 1 0.234345592 0.205492231 GOTERM_MF_DIRECT GO:0032451~demethylase activity 2 1.25 0.049261836 CYP1A2, CYP1A1 160 6 18967 39.51458333 1 0.234345592 0.205492231 GOTERM_MF_DIRECT GO:0070324~thyroid hormone binding 2 1.25 0.049261836 TTR, THRB 160 6 18967 39.51458333 1 0.234345592 0.205492231 GOTERM_MF_DIRECT GO:0045296~cadherin binding 7 4.375 0.053015676 HSPA8, HSP90AB1, HSPA5, SRC, KDR, EGFR, PLEC 160 320 18967 2.593144531 1 0.25041447 0.219582658 GOTERM_MF_DIRECT GO:0019955~cytokine binding 3 1.875 0.059066301 CSF1R, KIT, ELANE 160 47 18967 7.56662234 1 0.277029272 0.242920563 GOTERM_MF_DIRECT GO:0044183~protein binding involved in protein folding 3 1.875 0.065866384 HSPA8, HSP90AB1, HSPA5 160 50 18967 7.112625 1 0.30676232 0.268992785 GOTERM_MF_DIRECT GO:0019902~phosphatase binding 3 1.875 0.068188711 SYK, MAPK1, PPARA 160 51 18967 6.973161765 1 0.315372787 0.276543105 GOTERM_MF_DIRECT GO:0046983~protein dimerization activity 5 3.125 0.071562464 APP, HSP90AB1, STAT3, AHR, ABCG2 160 186 18967 3.186659946 1 0.328413144 0.287977892 GOTERM_MF_DIRECT GO:0047499~calcium-independent phospholipase A2 activity 2 1.25 0.072980699 PLA2G4A, PLA2G7 160 9 18967 26.34305556 1 0.328413144 0.287977892 GOTERM_MF_DIRECT GO:0061733~peptide-lysine-N-acetyltransferase activity 2 1.25 0.072980699 CREBBP, EP300 160 9 18967 26.34305556 1 0.328413144 0.287977892 GOTERM_MF_DIRECT GO:0017081~chloride channel regulator activity 2 1.25 0.072980699 TRPV1, CFTR 160 9 18967 26.34305556 1 0.328413144 0.287977892 GOTERM_MF_DIRECT GO:0070851~growth factor receptor binding 2 1.25 0.080755573 APP, SRC 160 10 18967 23.70875 1 0.35618021 0.31232619 GOTERM_MF_DIRECT GO:0043225~ATPase-coupled anion transmembrane transporter activity 2 1.25 0.080755573 ABCC1, CFTR 160 10 18967 23.70875 1 0.35618021 0.31232619 GOTERM_MF_DIRECT GO:1901363~heterocyclic compound binding 2 1.25 0.080755573 ACE, DRD2 160 10 18967 23.70875 1 0.35618021 0.31232619 GOTERM_MF_DIRECT GO:0031434~mitogen-activated protein kinase kinase binding 2 1.25 0.088465647 ACE, BRAF 160 11 18967 21.55340909 1 0.380116907 0.333315727 GOTERM_MF_DIRECT GO:0008503~benzodiazepine receptor activity 2 1.25 0.088465647 GABRA2, TSPO 160 11 18967 21.55340909 1 0.380116907 0.333315727 GOTERM_MF_DIRECT GO:0005131~growth hormone receptor binding 2 1.25 0.088465647 JAK3, JAK1 160 11 18967 21.55340909 1 0.380116907 0.333315727 GOTERM_MF_DIRECT GO:0048407~platelet-derived growth factor binding 2 1.25 0.088465647 PDGFRB, PDGFRA 160 11 18967 21.55340909 1 0.380116907 0.333315727 GOTERM_MF_DIRECT GO:0005543~phospholipid binding 4 2.5 0.089545684 PLA2G2A, PLA2G7, F3, SNCA 160 126 18967 3.763293651 1 0.382291189 0.335222304 GOTERM_MF_DIRECT GO:0070888~E-box binding 3 1.875 0.090224034 HDAC1, PPARG, AHR 160 60 18967 5.9271875 1 0.3827338 0.335610419 GOTERM_MF_DIRECT GO:0097677~STAT family protein binding 2 1.25 0.096111456 EP300, PPARG 160 12 18967 19.75729167 1 0.402580061 0.353013147 GOTERM_MF_DIRECT GO:0034452~dynactin binding 2 1.25 0.096111456 GSK3B, MAPT 160 12 18967 19.75729167 1 0.402580061 0.353013147 GOTERM_MF_DIRECT GO:0031072~heat shock protein binding 3 1.875 0.097978438 HSPA8, HSP90AB1, HSPA5 160 63 18967 5.644940476 1 0.407835247 0.357621298