1 BrainXcan results

In this analysis, we tested 327 structural and diffusion MRI-derived phenotypes with cross validated spearman correlation >= 0.101.

For the main analysis we focused on 261 IDPs, which include 48 cortical volumes, 10 sub-cortical volumes, 13 sub-cortical gray matter volumes. In below, we show the overall number of IDP by IDP subtype in the main results.

subtype n
Brainstem 1
FA 46
Gray-Brainstem 1
Gray-Cerebellum 27
Gray-Cortical 48
Gray-Subcortical 13
ICVF 44
ISOVF 13
OD 45
PC-Cerebellum-1 1
PC-Cortical-1 1
PC-FA-TBSS-1 1
PC-ICVF-TBSS-1 1
PC-ISOVF-TBSS-1 1
PC-OD-TBSS-1 1
PC-Subcortical_GMvol-1 1
PC-Subcortical_vol-1 1
Subcortical 10
Total 5

The p-value being used is .

Among 261 IDPs (109 T1 and 152 diffusion MRI, including the subtype-specific PCs), 187 were significantly associated with my_analysis (FDR < \(0.05\)).

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The top 10 associations for dMRI are

IDP subtype region side zscore fdr IDP -> Phenotype Phenotype -> IDP link
IDP-25069 FA superior cerebellar peduncle left 16.07 1.009e-55 0.003583 0.4643 MR plot
PC-OD-TBSS-1 PC-OD-TBSS-1 PC-OD-TBSS-1 NA -15.36 4.209e-51 0.3243 0.1561 MR plot
IDP-25404 OD superior cerebellar peduncle right -14.74 3.264e-47 0.006302 0.7935 MR plot
IDP-25357 ICVF superior cerebellar peduncle left 14.2 5.886e-44 2.962e-08 0.01327 MR plot
IDP-25068 FA superior cerebellar peduncle right 13.78 1.765e-41 0.001128 0.2165 MR plot
IDP-25356 ICVF superior cerebellar peduncle right 12.76 9.496e-36 2.682e-05 0.05181 MR plot
IDP-25405 OD superior cerebellar peduncle left -12.64 3.47e-35 0.1303 0.2707 MR plot
PC-FA-TBSS-1 PC-FA-TBSS-1 PC-FA-TBSS-1 NA 10.87 2.674e-26 NA NA NA
IDP-25065 FA medial lemniscus left 10.62 3.953e-25 NA NA NA
IDP-25059 FA body of corpus callosum NA -10.18 3.547e-23 NA NA NA

The top 10 associations for T1 are

IDP subtype region side zscore fdr IDP -> Phenotype Phenotype -> IDP link
IDP-25879 Gray-Subcortical thalamus right -13.56 3.031e-40 0.6402 0.02195 MR plot
IDP-25850 Gray-Cortical parahippocampal gyrus, posterior division left -13.51 5.286e-40 0.06333 0.1431 MR plot
IDP-25892 Gray-Brainstem brain-stem NA -12.19 9.081e-33 NA NA NA
IDP-25878 Gray-Subcortical thalamus left -11.97 1.19e-31 NA NA NA
IDP-25851 Gray-Cortical parahippocampal gyrus, posterior division right -11.79 1.012e-30 NA NA NA
IDP-25876 Gray-Cortical occipital pole left -11.21 6.968e-28 NA NA NA
IDP-25877 Gray-Cortical occipital pole right -11.16 1.206e-27 NA NA NA
IDP-25891 Gray-Subcortical ventral striatum right 10.58 5.674e-25 NA NA NA
IDP-25887 Gray-Subcortical hippocampus right -9.798 1.492e-21 NA NA NA
IDP-25886 Gray-Subcortical hippocampus left -9.286 1.822e-19 NA NA NA

2 Visualization of associations in the brain

2.1 T1

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2.2 dMRI

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3 BrainXcan MR Figures

3.1 IDP-25068

Mean FA (fractional anisotropy) in superior cerebellar peduncle (right) on FA skeleton (from dMRI data)

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3.2 IDP-25069

Mean FA (fractional anisotropy) in superior cerebellar peduncle (left) on FA skeleton (from dMRI data)

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3.3 IDP-25356

Mean ICVF (intra-cellular volume fraction) in superior cerebellar peduncle (right) on FA (fractional anisotropy) skeleton (from dMRI data)

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3.4 IDP-25357

Mean ICVF (intra-cellular volume fraction) in superior cerebellar peduncle (left) on FA (fractional anisotropy) skeleton (from dMRI data)

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3.5 IDP-25404

Mean OD (orientation dispersion index) in superior cerebellar peduncle (right) on FA (fractional anisotropy) skeleton (from dMRI data)

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3.6 IDP-25405

Mean OD (orientation dispersion index) in superior cerebellar peduncle (left) on FA (fractional anisotropy) skeleton (from dMRI data)

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3.7 PC-OD-TBSS-1

PC-OD-TBSS-1

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3.8 IDP-25850

Volume of grey matter in Left Parahippocampal Gyrus, posterior division

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3.9 IDP-25879

Volume of grey matter in Right Thalamus

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