Supplementary Table 2: MetagenomeSeq analysis results in both CP and control groups. ID logFC se pvalues adjPvalues kingdom phylum class order family genus species ASV_29819 4.124 1.305 0.001574 0.02839 d__Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium perfringens ASV_25473 3.063 0.8702 0.0004309 0.01037 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_20781 2.772 0.9342 0.003009 0.04505 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea unidentified_Dorea ASV_2177 2.623 0.5756 5.20E-06 0.0002713 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia Escherichia coli ASV_33263 2.438 0.7059 0.0005542 0.01262 d__Bacteria Firmicutes Erysipelotrichi Erysipelotrichales Erysipelotrichaceae Clostridium Clostridium ramosum ASV_6790 2.091 0.5207 5.95E-05 0.00209 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_10463 1.973 0.5233 0.0001627 0.004758 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea unidentified_Dorea ASV_1125 1.934 0.6416 0.002584 0.04076 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unidentified_Enterobacteriaceae unidentified_Enterobacteriaceae ASV_26391 1.821 0.4051 6.96E-06 0.0003419 d__Bacteria Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella unidentified_Collinsella ASV_4997 1.478 0.3566 3.38E-05 0.001289 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_21131 1.421 0.376 0.0001564 0.004737 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_8343 1.415 0.403 0.0004474 0.01061 d__Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae SMB53 unidentified_SMB53 ASV_35695 1.337 0.3985 0.000792 0.01679 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_24119 1.297 0.3241 6.33E-05 0.002146 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Shigella unclassified_Shigella ASV_18578 1.272 0.2549 5.98E-07 4.41E-05 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unclassified_Enterobacteriaceae unclassified_Enterobacteriaceae ASV_3789 1.257 0.325 0.0001092 0.0034 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unclassified_Lachnospiraceae unclassified_Lachnospiraceae ASV_13147 1.198 0.2207 5.68E-08 5.52E-06 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unclassified_Enterobacteriaceae unclassified_Enterobacteriaceae ASV_20766 1.187 0.3281 0.0002974 0.007703 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_30973 1.169 0.3398 0.0005795 0.01311 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea unidentified_Dorea ASV_5189 1.108 0.3732 0.002982 0.04505 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_2006 1.098 0.353 0.001868 0.03232 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_23246 1.097 0.3606 0.002345 0.03843 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Clostridium Clostridium clostridioforme ASV_8648 1.092 0.254 1.72E-05 0.0007511 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unidentified_Enterobacteriaceae unidentified_Enterobacteriaceae ASV_34346 1.087 0.3351 0.001178 0.02296 d__Bacteria Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella unidentified_Collinsella ASV_10017 1.084 0.291 0.0001945 0.005591 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Klebsiella unidentified_Klebsiella ASV_27060 1.068 0.365 0.003421 0.04977 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_12558 1.01 0.3428 0.003207 0.04729 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_6282 1.009 0.2402 2.65E-05 0.001098 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unclassified_Enterobacteriaceae unclassified_Enterobacteriaceae ASV_21959 1.009 0.3265 0.002008 0.03406 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_32810 0.9804 0.3226 0.002372 0.03861 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_28631 0.9515 0.2819 0.0007372 0.01583 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_31315 0.9302 0.2879 0.001232 0.02388 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_18549 0.9273 0.314 0.003145 0.04679 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_8565 0.8952 0.2146 3.04E-05 0.001225 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia Escherichia coli ASV_4751 0.8709 0.2859 0.002322 0.03824 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae unclassified_Ruminococcaceae unclassified_Ruminococcaceae ASV_36176 0.851 0.2728 0.00181 0.03149 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_18540 0.824 0.2666 0.001999 0.03406 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_27163 0.782 0.2156 0.0002857 0.007571 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Providencia unidentified_Providencia ASV_19396 0.7198 0.204 0.0004172 0.01011 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_28005 0.6668 0.2104 0.001525 0.02782 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unidentified_Enterobacteriaceae unidentified_Enterobacteriaceae ASV_8298 0.6115 0.2002 0.002258 0.03755 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_4461 0.5582 0.1848 0.002527 0.0402 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_35788 0.5515 0.1767 0.001801 0.03149 d__Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae unidentified_Streptococcaceae unidentified_Streptococcaceae ASV_22386 0.5312 0.1773 0.002732 0.04231 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unclassified_Lachnospiraceae unclassified_Lachnospiraceae ASV_11347 0.5093 0.1457 0.0004744 0.01095 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unclassified_Enterobacteriaceae unclassified_Enterobacteriaceae ASV_26076 -0.3187 0.1066 0.002805 0.04325 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_23374 -0.4065 0.1308 0.001888 0.0325 d__Bacteria Firmicutes Bacilli Lactobacillales Leuconostocaceae unidentified_Leuconostocaceae unidentified_Leuconostocaceae ASV_31168 -0.4457 0.1422 0.001723 0.03071 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_18402 -0.4715 0.1588 0.002996 0.04505 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_13355 -0.4877 0.1516 0.001294 0.02481 d__Bacteria Firmicutes Bacilli Lactobacillales Enterococcaceae Enterococcus unidentified_Enterococcus ASV_3329 -0.5029 0.1468 0.0006106 0.01354 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_29190 -0.5233 0.165 0.001521 0.02782 d__Bacteria Firmicutes Clostridia Clostridiales Peptococcaceae rc4-4 unidentified_rc4-4 ASV_16115 -0.5505 0.1715 0.001328 0.02532 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides unidentified_Parabacteroides ASV_24491 -0.5613 0.1689 0.0008882 0.01804 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_35893 -0.5632 0.1887 0.00284 0.04359 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Mitsuokella unidentified_Mitsuokella ASV_20748 -0.5669 0.1694 0.0008175 0.01712 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea unidentified_Dorea ASV_30742 -0.5734 0.1637 0.000459 0.01074 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_19720 -0.5934 0.1622 0.0002542 0.006953 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unclassified_Bacteroides ASV_15084 -0.5999 0.1879 0.001408 0.02645 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_26997 -0.6064 0.1894 0.001364 0.02584 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unclassified_Bacteroides ASV_25551 -0.6099 0.1839 0.0009132 0.01837 d__Bacteria Firmicutes Bacilli Lactobacillales Leuconostocaceae unclassified_Leuconostocaceae unclassified_Leuconostocaceae ASV_17934 -0.6119 0.2085 0.003335 0.04897 d__Bacteria Firmicutes Clostridia Clostridiales unidentified_Clostridiales unidentified_Clostridiales unidentified_Clostridiales ASV_24255 -0.6169 0.2079 0.003005 0.04505 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_21799 -0.6179 0.1919 0.001281 0.02469 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_3699 -0.637 0.1996 0.001411 0.02645 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes unclassified_Alistipes ASV_6460 -0.6662 0.2196 0.002413 0.03861 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_31383 -0.6847 0.2247 0.002311 0.03824 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis ASV_1042 -0.6958 0.1907 0.0002644 0.00708 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella parvula ASV_11990 -0.6968 0.2308 0.002536 0.0402 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides unidentified_Parabacteroides ASV_32709 -0.7037 0.2294 0.002161 0.03628 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unclassified_Enterobacteriaceae unclassified_Enterobacteriaceae ASV_22264 -0.7085 0.2068 0.0006108 0.01354 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_9145 -0.7148 0.229 0.0018 0.03149 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae unidentified_Ruminococcaceae unidentified_Ruminococcaceae ASV_14492 -0.7252 0.1822 6.90E-05 0.002295 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_410 -0.7453 0.2379 0.001729 0.03071 d__Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus Haemophilus parainfluenzae ASV_29497 -0.7642 0.2606 0.003368 0.04924 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia unidentified_Roseburia ASV_11510 -0.7719 0.2134 0.0002975 0.007703 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella dispar ASV_8759 -0.7752 0.265 0.003443 0.04977 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus catus ASV_15949 -0.7781 0.2166 0.0003282 0.008371 d__Bacteria Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella unidentified_Collinsella ASV_14906 -0.7975 0.258 0.001991 0.03406 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unidentified_Enterobacteriaceae unidentified_Enterobacteriaceae ASV_33527 -0.8003 0.2457 0.001124 0.02204 d__Bacteria Firmicutes Clostridia Clostridiales unclassified_Clostridiales unclassified_Clostridiales unclassified_Clostridiales ASV_16161 -0.8237 0.1801 4.79E-06 0.0002578 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_10754 -0.835 0.2046 4.48E-05 0.001618 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unclassified_Bifidobacterium ASV_21927 -0.843 0.2146 8.56E-05 0.002739 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_16000 -0.8631 0.2826 0.002258 0.03755 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_37033 -0.8794 0.179 9.04E-07 6.30E-05 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_4608 -0.8813 0.2605 0.0007152 0.01555 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_10336 -0.8828 0.2338 0.0001595 0.004745 d__Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus unidentified_Streptococcus ASV_33772 -0.9038 0.2849 0.001513 0.02782 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium breve ASV_25183 -0.909 0.2272 6.31E-05 0.002146 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus catus ASV_29792 -0.921 0.2055 7.44E-06 0.0003604 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_6940 -0.9262 0.314 0.003178 0.04708 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_11695 -0.9387 0.2376 7.78E-05 0.002563 d__Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus unidentified_Streptococcus ASV_10043 -0.9547 0.246 0.0001039 0.003295 d__Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae unidentified_Streptococcaceae unidentified_Streptococcaceae ASV_14778 -0.956 0.3034 0.001627 0.0292 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_17089 -0.9943 0.2976 0.000833 0.01724 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae unclassified_Ruminococcaceae unclassified_Ruminococcaceae ASV_9903 -0.998 0.3013 0.0009235 0.01843 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_31706 -1.009 0.2994 0.000754 0.01608 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Klebsiella unidentified_Klebsiella ASV_19795 -1.01 0.3014 0.0008011 0.01688 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_4009 -1.027 0.2862 0.0003346 0.008469 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus catus ASV_23859 -1.029 0.2697 0.0001367 0.004176 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unclassified_Bifidobacterium ASV_15584 -1.031 0.2827 0.0002651 0.00708 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus unidentified_Ruminococcus ASV_2055 -1.032 0.3094 0.0008472 0.01742 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Mitsuokella unclassified_Mitsuokella ASV_25531 -1.033 0.2188 2.36E-06 0.0001479 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia unidentified_Roseburia ASV_26818 -1.036 0.3062 0.0007203 0.01556 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_34619 -1.038 0.3029 0.0006062 0.01354 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae unclassified_Ruminococcaceae unclassified_Ruminococcaceae ASV_26291 -1.048 0.1932 5.69E-08 5.52E-06 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_13109 -1.052 0.2321 5.84E-06 0.0002976 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_26834 -1.061 0.3578 0.003015 0.04505 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_608 -1.072 0.2882 0.0001995 0.005686 d__Bacteria Firmicutes Erysipelotrichi Erysipelotrichales Erysipelotrichaceae Holdemania unidentified_Holdemania ASV_6911 -1.074 0.2906 0.0002177 0.006155 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_31748 -1.085 0.3274 0.0009155 0.01837 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_32399 -1.087 0.2108 2.52E-07 2.03E-05 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_23803 -1.088 0.3048 0.0003584 0.00881 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis ASV_15215 -1.094 0.2073 1.32E-07 1.14E-05 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_12202 -1.095 0.2548 1.73E-05 0.0007511 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_32325 -1.102 0.2433 5.88E-06 0.0002976 d__Bacteria Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus unclassified_Lactobacillus ASV_12461 -1.103 0.3773 0.003448 0.04977 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Butyricicoccus Butyricicoccus pullicaecorum ASV_25558 -1.104 0.2849 0.0001066 0.003347 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_27833 -1.113 0.2708 3.96E-05 0.001458 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unclassified_Bifidobacterium ASV_21628 -1.158 0.3093 0.0001807 0.005239 d__Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus unclassified_Streptococcus ASV_13019 -1.179 0.3257 0.0002954 0.007703 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia obeum ASV_20477 -1.179 0.3361 0.0004524 0.01066 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_33603 -1.182 0.2172 5.29E-08 5.44E-06 d__Bacteria Actinobacteria Actinobacteria Actinomycetales Actinomycetaceae Actinomyces unidentified_Actinomyces ASV_556 -1.184 0.3323 0.0003684 0.008991 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea Dorea formicigenerans ASV_13220 -1.203 0.3285 0.0002491 0.00687 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea Dorea formicigenerans ASV_11253 -1.237 0.3701 0.0008333 0.01724 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_14913 -1.26 0.3418 0.0002282 0.006344 d__Bacteria Actinobacteria Actinobacteria Actinomycetales Actinomycetaceae Actinomyces unidentified_Actinomyces ASV_1597 -1.261 0.3055 3.65E-05 0.001359 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_31871 -1.265 0.195 8.62E-11 1.46E-08 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_24117 -1.3 0.266 1.03E-06 6.96E-05 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unclassified_Bifidobacterium ASV_22170 -1.338 0.3137 1.99E-05 0.0008539 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_11439 -1.344 0.4471 0.002645 0.04116 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea Dorea formicigenerans ASV_1371 -1.365 0.4584 0.00291 0.04447 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis ASV_31794 -1.418 0.2924 1.23E-06 8.18E-05 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_13373 -1.424 0.4072 0.0004716 0.01095 d__Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus Haemophilus parainfluenzae ASV_8641 -1.469 0.3108 2.31E-06 0.0001478 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_29847 -1.49 0.3372 1.00E-05 0.0004694 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_35536 -1.523 0.3306 4.10E-06 0.0002279 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Clostridium Clostridium clostridioforme ASV_9105 -1.54 0.3526 1.26E-05 0.0005784 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_18670 -1.563 0.3666 2.01E-05 0.0008539 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Oscillospira unidentified_Oscillospira ASV_14947 -1.566 0.3761 3.15E-05 0.001255 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unidentified_Bacteroides ASV_11029 -1.595 0.5298 0.002611 0.041 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia faecis ASV_26434 -1.609 0.4181 0.0001194 0.003681 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae unclassified_Enterobacteriaceae unclassified_Enterobacteriaceae ASV_4612 -1.619 0.4767 0.0006835 0.01496 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia unclassified_Roseburia ASV_35129 -1.626 0.5357 0.002398 0.03861 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis ASV_1627 -1.631 0.3132 1.92E-07 1.63E-05 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae unclassified_Ruminococcaceae unclassified_Ruminococcaceae ASV_11507 -1.631 0.347 2.59E-06 0.0001566 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides distasonis ASV_37503 -1.64 0.3932 3.01E-05 0.001225 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_10830 -1.645 0.4936 0.0008592 0.01756 d__Bacteria Firmicutes Erysipelotrichi Erysipelotrichales Erysipelotrichaceae unidentified_Erysipelotrichaceae unidentified_Erysipelotrichaceae ASV_19613 -1.664 0.4792 0.0005152 0.01181 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_29041 -1.697 0.3456 9.10E-07 6.30E-05 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides distasonis ASV_5864 -1.716 0.5388 0.001452 0.02707 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_28164 -1.744 0.53 0.001002 0.01988 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_36986 -1.76 0.3214 4.34E-08 4.60E-06 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea Dorea formicigenerans ASV_4238 -1.79 0.4426 5.27E-05 0.00188 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Klebsiella unidentified_Klebsiella ASV_7667 -1.801 0.3043 3.26E-09 3.95E-07 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unclassified_Lachnospiraceae unclassified_Lachnospiraceae ASV_20157 -1.812 0.5559 0.001115 0.02198 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea unidentified_Dorea ASV_31368 -1.834 0.1955 0 0 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae unclassified_Ruminococcaceae unclassified_Ruminococcaceae ASV_8134 -1.836 0.4652 7.92E-05 0.002582 d__Bacteria Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella Collinsella aerofaciens ASV_3503 -1.841 0.5242 0.0004457 0.01061 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_33874 -1.875 0.4674 6.04E-05 0.00209 d__Bacteria Proteobacteria Betaproteobacteria Burkholderiales Alcaligenaceae Sutterella unidentified_Sutterella ASV_16888 -1.887 0.2756 7.42E-12 1.50E-09 d__Bacteria Proteobacteria Betaproteobacteria Burkholderiales Alcaligenaceae Sutterella unidentified_Sutterella ASV_16675 -1.906 0.2784 7.50E-12 1.50E-09 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_7073 -1.907 0.3778 4.46E-07 3.44E-05 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_7244 -1.928 0.3064 3.11E-10 4.59E-08 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_26305 -1.932 0.379 3.42E-07 2.70E-05 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_18141 -1.951 0.4956 8.29E-05 0.002678 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unclassified_Lachnospiraceae unclassified_Lachnospiraceae ASV_16978 -2.046 0.3265 3.67E-10 5.18E-08 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium longum ASV_34926 -2.058 0.4413 3.12E-06 0.0001796 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unclassified_Lachnospiraceae unclassified_Lachnospiraceae ASV_35464 -2.103 0.4259 7.86E-07 5.67E-05 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_16027 -2.119 0.4649 5.20E-06 0.0002713 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis ASV_31603 -2.127 0.3974 8.73E-08 8.00E-06 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia unidentified_Roseburia ASV_36139 -2.155 0.4632 3.29E-06 0.0001861 d__Bacteria Firmicutes Bacilli Lactobacillales Lactobacillaceae unclassified_Lactobacillaceae unclassified_Lactobacillaceae ASV_9740 -2.169 0.3922 3.19E-08 3.49E-06 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis ASV_33602 -2.199 0.3339 4.49E-11 8.01E-09 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia unidentified_Roseburia ASV_16854 -2.228 0.4448 5.49E-07 4.14E-05 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_23 -2.231 0.2951 4.09E-14 1.18E-11 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea Dorea longicatena ASV_32654 -2.234 0.6245 0.0003476 0.008669 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea Dorea formicigenerans ASV_10179 -2.27 0.5097 8.41E-06 0.0004017 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis ASV_27259 -2.275 0.3385 1.81E-11 3.42E-09 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unclassified_Lachnospiraceae unclassified_Lachnospiraceae ASV_12741 -2.283 0.7415 0.002078 0.03507 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unidentified_Bifidobacterium ASV_16934 -2.292 0.6214 0.000226 0.006335 d__Bacteria Firmicutes Erysipelotrichi Erysipelotrichales Erysipelotrichaceae Bulleidia Bulleidia moorei ASV_16510 -2.294 0.3849 2.52E-09 3.16E-07 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_3377 -2.316 0.4176 2.91E-08 3.29E-06 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Mitsuokella unidentified_Mitsuokella ASV_9921 -2.317 0.7298 0.001501 0.02782 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella dispar ASV_8630 -2.332 0.6174 0.0001588 0.004745 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella dispar ASV_36228 -2.351 0.338 3.50E-12 9.13E-10 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_2087 -2.357 0.7444 0.001544 0.028 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_22209 -2.366 0.5723 3.58E-05 0.001349 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae [Ruminococcus] [Ruminococcus] gnavus ASV_35154 -2.377 0.5041 2.40E-06 0.0001479 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella parvula ASV_22693 -2.389 0.4505 1.13E-07 1.01E-05 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_37326 -2.398 0.3904 8.08E-10 1.10E-07 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Mitsuokella unidentified_Mitsuokella ASV_33073 -2.411 0.7944 0.002408 0.03861 d__Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium unclassified_Clostridium ASV_22849 -2.419 0.4267 1.44E-08 1.69E-06 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Mitsuokella unidentified_Mitsuokella ASV_25011 -2.438 0.3227 4.17E-14 1.18E-11 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus catus ASV_4890 -2.445 0.6844 0.0003541 0.008768 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unidentified_Bifidobacterium ASV_779 -2.463 0.5353 4.20E-06 0.0002297 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium longum ASV_620 -2.496 0.4097 1.11E-09 1.45E-07 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_22827 -2.508 0.3971 2.71E-10 4.18E-08 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia unidentified_Blautia ASV_5936 -2.51 0.5764 1.33E-05 0.0006009 d__Bacteria Firmicutes Bacilli Lactobacillales Leuconostocaceae Weissella unclassified_Weissella ASV_28880 -2.564 0.2902 0 0 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_31171 -2.573 0.8805 0.003474 0.04993 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_18441 -2.588 0.4063 1.88E-10 3.03E-08 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unclassified_Lachnospiraceae unclassified_Lachnospiraceae ASV_21566 -2.666 0.6645 6.02E-05 0.00209 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_21245 -2.701 0.8637 0.001768 0.03123 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides unclassified_Bacteroides ASV_20058 -2.728 0.3977 6.85E-12 1.50E-09 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_34981 -2.743 0.6614 3.37E-05 0.001289 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_21732 -2.756 0.331 0 0 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia obeum ASV_291 -2.759 0.3069 0 0 d__Bacteria Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Slackia unidentified_Slackia ASV_17373 -2.837 0.5473 2.17E-07 1.80E-05 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella dispar ASV_31715 -2.878 0.6775 2.15E-05 0.000901 d__Bacteria Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella unidentified_Collinsella ASV_23986 -2.883 0.8054 0.0003436 0.008633 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_2594 -2.91 0.7114 4.29E-05 0.001566 d__Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus unidentified_Streptococcus ASV_21425 -2.952 0.7106 3.27E-05 0.001275 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella dispar ASV_3230 -3.01 0.6424 2.80E-06 0.0001664 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella parvula ASV_34947 -3.073 0.4449 4.94E-12 1.20E-09 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Mitsuokella unidentified_Mitsuokella ASV_18033 -3.084 0.6489 2.01E-06 0.0001312 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_30468 -3.125 0.9182 0.0006654 0.01466 d__Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Klebsiella unclassified_Klebsiella ASV_28019 -3.126 0.5824 8.01E-08 7.55E-06 d__Bacteria Firmicutes Clostridia Clostridiales Veillonellaceae Veillonella Veillonella parvula ASV_22305 -3.164 0.6996 6.11E-06 0.0003046 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides caccae ASV_32515 -3.172 0.7184 1.01E-05 0.0004694 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis ASV_21253 -3.202 1.065 0.002642 0.04116 d__Bacteria Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides caccae ASV_13640 -3.232 0.894 0.0003009 0.007732 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_28048 -3.236 0.8871 0.0002644 0.00708 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus unidentified_Coprococcus ASV_7474 -3.287 0.3542 0 0 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unclassified_Bifidobacterium ASV_20124 -3.612 0.837 1.59E-05 0.0007098 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_11852 -3.696 0.9252 6.48E-05 0.002177 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae unidentified_Ruminococcaceae unidentified_Ruminococcaceae ASV_6070 -3.772 1 0.0001619 0.004758 d__Bacteria Firmicutes Clostridia Clostridiales Lachnospiraceae unidentified_Lachnospiraceae unidentified_Lachnospiraceae ASV_33654 -3.952 1.302 0.002403 0.03861 d__Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus unidentified_Streptococcus ASV_236 -4.499 0.4785 0 0 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unidentified_Bifidobacterium ASV_11149 -4.597 0.4968 0 0 d__Bacteria Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii ASV_12380 -4.631 0.456 0 0 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium longum ASV_4422 -4.801 0.447 0 0 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unidentified_Bifidobacterium ASV_23455 -4.908 0.4579 0 0 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium unclassified_Bifidobacterium ASV_273 -5.011 1.07 2.85E-06 0.0001664 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium adolescentis ASV_21324 -5.041 1.212 3.21E-05 0.001265 d__Bacteria Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium adolescentis