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{"sheet":"Supplementary_Table1","index":0,"n_rows":69,"n_cols":10,"rows_kept":69,"merged":[[0,0,0,18],[2,2,2,3],[2,4,2,5],[2,6,2,7],[2,8,2,9],[4,2,4,3],[4,4,4,5],[4,6,4,7],[4,8,4,9],[11,2,11,3],[11,4,11,5],[11,6,11,7],[11,8,11,9],[15,2,15,3],[15,4,15,5],[15,6,15,7],[15,8,15,9],[19,2,19,3],[19,4,19,5],[19,6,19,7],[19,8,19,9],[23,2,23,3],[23,4,23,5],[23,6,23,7],[23,8,23,9],[27,2,27,3],[27,4,27,5],[27,6,27,7],[27,8,27,9],[31,2,31,3],[31,4,31,5],[31,6,31,7],[31,8,31,9],[35,2,35,3],[35,4,35,5],[35,6,35,7],[35,8,35,9],[39,2,39,3],[39,4,39,5],[39,6,39,7],[39,8,39,9],[43,2,43,3],[43,4,43,5],[43,6,43,7],[43,8,43,9],[47,2,47,3],[47,4,47,5],[47,6,47,7],[47,8,47,9],[51,2,51,3],[51,4,51,5],[51,6,51,7],[51,8,51,9],[57,2,57,3],[57,4,57,5],[57,6,57,7],[57,8,57,9],[61,2,61,3],[61,4,61,5],[61,6,61,7],[61,8,61,9]]}
["Two-sided Fisher's exact test results and patient numbers of the LMU-KKG (n=145), TCGA (n=241), GSE65858 (n=176), and GSE41613 (n=96) cohorts HPV-negative cases with MPS and prognostic clinical variables. "]
[]
[null,null,"LMU-KKG (n=145)",null,"TCGA (n=241)",null,"GSE65858 (n=176)",null,"GSE41613 (n=96)"]
[null,null,"MPS1 (n=87)","MPS2 (n=58)","MPS1 (n=122)","MPS2 (n=119)","MPS1 (n=76)","MPS2 (n=100)","MPS1 (n=46)","MPS2 (n=50)"]
["Age category",null,"P=0.554 (P adj.=1)",null,"P=0.662 (P adj.=0.676)",null,"P=0.014 (P adj.=0.098)",null,"P=0.135 (P adj.=0.135)"]
[null,"<45 *(19-39)","2 (2.3%)","1 (1.7%)","10 (8.2%)","7 (5.9%)","4 (5.3%)","10 (10%)","5 (10.9%)","1 (2%)"]
[null,"45-54 *(40-49)","17 (19.5%)","7 (12.1%)","23 (18.9%)","18 (15.1%)","16 (21%)","30 (30%)","10 (21.7%)","6 (12%)"]
[null,"55-64 *(50-59)","32 (36.8%)","23 (39.7%)","33 (27%)","36 (30.3%)","22 (28.9%)","39 (39%)","11 (23.9%)","17 (34%)"]
[null,"65-74  *(60-88)","29 (33.4%)","24 (41.4%)","41 (33.6%)","37 (31.1%)","23 (30.3%)","17 (17%)","20 (43.5%)","26 (52%)"]
[null,"75>","7 (8%)","2 (3.4%)","15 (12.3%)","21 (17.6%)","11 (14.5%)","4 (4%)","-","-"]
[null,"Missing information","-","1 (1.7%)","-","-","-","-","-","-"]
["Sex",null,"P=0.670 (P adj.=1)",null,"P=0.676 (P adj.=0.676)",null,"P=1 (P adj.=1)",null,"P=0.084 (P adj.=0.126)"]
[null,"Male","66 (75.9%)","42 (72.4%)","84 (68.9%)","85 (71.4%)","66 (86.8%)","86 (86%)","27 (58.7%)","38 (76%)"]
[null,"Female","21 (24.1%)","16 (27.6%) ","38 (31.1%)","34 (28.6%)","10 (13.2%)","14 (14%)","19 (41.3%)","12 (24%)"]
[null,"Missing information","-","-","-","-","-","-","-","-"]
["TNM T stage group",null,"P=0.733 (P adj.=1)",null,"P=0.337 (P adj.=0.676)",null,"P=0.441 (P adj.=0.658)",null,"-"]
[null,"T1-T2","50 (57.5%)","31 (53.4%)","36 (29.5%)","43 (36.1%)","28 (36.8%)","43 (43%)","-","-"]
[null,"T3-T4","37 (42.5%)","27 (46.6%)","86 (70.5%)","76 (63.9%)","48 (63.2%)","57 (57%)","-","-"]
[null,"Missing information","-","-","-","-","-","-","46 (100%)","50 (100%)"]
["TNM N stage group",null,"P=0.498 (P adj.=1)",null,"P=0.015 (P adj.=0.075)",null,"P=0.651 (P adj.=0.760)",null,"-"]
[null,"N0-N1","43 (49.4%)","32 (55.2%)","77 (63.1%)","92 (77.3%)","36 (47.4%)","51 (51%)","-","-"]
[null,"N2-N3","43 (49.4%)","25 (43.1%)","44 (36.1%)","25 (21%)","40 (52.6%)","49 (49%)","-","-"]
[null,"Missing information","1 (1.1%)","1 (1.7%)","1 (0.8%)","2 (1.7%)","-","-","46 (100%)","50 (100%)"]
["Resection margin status",null,"P=0.834 (P adj.=1)",null,"-",null,"-",null,"-"]
[null,"R0","69 (79.3%)","44 (75.9%)","-","-","-","-","-","-"]
[null,"R1","17 (19.5%)","12 (20.7%)","-","-","-","-","-","-"]
[null,"Missing information","1 (1.1%)","2 (3.4%)","122 (100%)","119 (100%)","76 (100%)","100 (100%)","46 (100%)","50 (100%)"]
["LVI stage",null,"P=0.847 (P adj.=1)",null,"-",null,"-",null,"-"]
[null,"LVI0","62 (71.3%)","36 (62.1%)","-","-","-","-","-","-"]
[null,"LVI1","24 (27.6%)","16 (27.6%)","-","-","-","-","-","-"]
[null,"Missing information","1 (1.1%)","6 (10.3%)","122 (100%)","119 (100%)","76 (100%)","100 (100%)","46 (100%)","50 (100%)"]
["VTI stage",null,"P=0.632 (P adj.=1)",null,"-",null,"-",null,"-"]
[null,"VTI0","2 (2.3%)","2 (3.4%)","-","-","-","-","-","-"]
[null,"VTI1","84 (96.6%)","50 (86.2%)","-","-","-","-","-","-"]
[null,"Missing information","1 (1.1%)","6 (10.3%)","122 (100%)","119 (100%)","76 (100%)","100 (100%)","46 (100%)","50 (100%)"]
["PNI stage",null,"P=1 (P adj.=1)",null,"-",null,"-",null,"-"]
[null,"PNI0","61 (70.1%)","40 (69%)","-","-","-","-","-","-"]
[null,"PNI1","14 (16.1%)","10 (17.2%)","-","-","-","-","-","-"]
[null,"Missing information","12 (13.8%)","8 (13.8%)","122 (100%)","119 (100%)","76 (100%)","100 (100%)","46 (100%)","50 (100%)"]
["UICC stage group",null,"P=1 (P adj.=1)",null,"-",null,"P=0.470 (P adj.=0.658)",null,"P=0.066 (P adj.=0.126)"]
[null,"UICC1-2","14 (16.1%)","10 (17.2%)","-","-","15 (19.7%)","25 (25%)","15 (32.6%)","26 (52%)"]
[null,"UICC3-4","73 (83.9%)","48 (82.8%)","-","-","61 (80.3%)","75 (75%)","31 (67.4%)","24 (48%)"]
[null,"Missing information","-","-","122 (100%)","119 (100%)","-","-","-","-"]
["Grading group",null,"P=0.302 (P adj.=1)",null,"-",null,"-",null,"-"]
[null,"Grading 1-2","36 (41.4%)","29 (50%)","-","-","-","-","-","-"]
[null,"Grading 3","50 (57.5%)","27 (46.6%)","-","-","-","-","-","-"]
[null,"Missing information","1 (1.1%)","2 (3.4%)","122 (100%)","119 (100%)","76 (100%)","100 (100%)","46 (100%)","50 (100%)"]
["ECE",null,"P=1 (P adj.=1)",null,"-",null,"-",null,"-"]
[null,"Yes","22 (25.3%)","14 (24.1%)","-","-","-","-","-","-"]
[null,"No/Not applicable","63 (72.4%)","42 (72.4%)","-","-","-","-","-","-"]
[null,"Missing information","2 (2.3%)","2 (3.4%)","122 (100%)","119 (100%)","76 (100%)","100 (100%)","46 (100%)","50 (100%)"]
["Tumor location",null,"P=0.516 (P adj.=1)",null,"P=0.656 (P adj.=0.676)",null,"P=0.168 (P adj.=0.392)",null,"-"]
[null,"Larynx","12 (13.8%)","11 (19%)","34 (27.9%)","37 (31.1%)","12 (15.8%)","28 (28%)","-","-"]
[null,"Hypopharynx","11 (12.6%)","11 (19%)","1 (0.8%)","-","14 (18.4%)","11 (11%)","-","-"]
[null,"Oropharynx","35 (40.2%)","21 (36.2%)","7 (5.7%)","4 (3.4%)","18 (23.7%)","28 (28%)","-","-"]
[null,"Oral cavity","29 (33.3%)","15 (25.8%)","80 (65.6%)","78 (65.5%)","30 (39.5%)","32 (32%)","-","-"]
[null,"Missing information","-","-","-","-","2 (2.6%)","1 (1%)","46 (100%)","50 (100%)"]
["Chemotherapy (yes/no)",null,"P=0.498 (P adj.=1)",null,"-",null,"-",null,"-"]
[null,"Yes","45 (51.7%)","33 (56.9%)","-","-","-","-","-","-"]
[null,"No","42 (48.3%)","24 (41.4%)","-","-","-","-","-","-"]
[null,"Missing information","-","1 (1.7%)","122 (100%)","119 (100%)","76 (100%)","100 (100%)","46 (100%)","50 (100%)"]
["Smoking status",null,"P=0.368 (P adj.=1)",null,"-",null,"P=0.034 (P adj.=0.119)",null,"-"]
[null,"Smoker","81 (93.1%)","48 (82.8%)","-","-","62 (81.6%)","93 (93%)","-","-"]
[null,"Nonsmoker","2 (2.3%)","3 (5.2%)","-","-","14 (18.4%)","7 (7%)","-","-"]
[null,"Missing information","4 (4.6%)","7 (12%)","122 (100%)","119 (100%)","-","-","46 (100%)","50 (100%)"]
[]
["NOTE: Data are numbers (%)."]
["*: Age categories available for the cohort GSE41613."]
["Clinical features were defined according to AJCC 7th edition."]

{"sheet":"Supplementary_Table2","index":1,"n_rows":70,"n_cols":4,"rows_kept":70,"merged":[[0,0,0,8]]}
["MPS1 vs. MPS2 differential testing results on the KEGG metabolic pathways GSVA enrichment scores for the LMU-KKG cohort HPV-negative cases (n=145). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["09107 Glycan biosynthesis and metabolism - 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate [PATH:hsa00532]","1.2260722310564E-05","2.60540349099486E-05",3607]
["09107 Glycan biosynthesis and metabolism - 00604 Glycosphingolipid biosynthesis - ganglio series [PATH:hsa00604]","1.01826325851758E-05","2.23360972836115E-05",3617]
["09107 Glycan biosynthesis and metabolism - 00511 Other glycan degradation [PATH:hsa00511]","0.000703684862718","0.001112803968949",3363]
["09107 Glycan biosynthesis and metabolism - 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin [PATH:hsa00534]","0.010939171151945","0.015497159131923",3154]
["09107 Glycan biosynthesis and metabolism - 00514 Other types of O-glycan biosynthesis [PATH:hsa00514]","0.115954335218781","0.146016570275502",2913]
["09107 Glycan biosynthesis and metabolism - 00513 Various types of N-glycan biosynthesis [PATH:hsa00513]","0.112257558375212","0.144028565462537",2917]
["09107 Glycan biosynthesis and metabolism - 00531 Glycosaminoglycan degradation [PATH:hsa00531]","0.406890668299122","0.461142757405671",2729]
["09107 Glycan biosynthesis and metabolism - 00515 Mannose type O-glycan biosynthesis [PATH:hsa00515]","0.501597943350263","0.541407303933617",2690]
["09101 Carbohydrate metabolism - 00562 Inositol phosphate metabolism [PATH:hsa00562]","0.257604835361936","0.307318049203713",2804]
["09107 Glycan biosynthesis and metabolism - 00510 N-Glycan biosynthesis [PATH:hsa00510]","0.857468471364857","0.8702665082509",2568]
["09104 Nucleotide metabolism - 00230 Purine metabolism [PATH:hsa00230]","0.822763107734132","0.847695323120015",2579]
["09108 Metabolism of cofactors and vitamins - 00670 One carbon pool by folate [PATH:hsa00670]","0.969415749339163","0.969415749339163",2513]
["09108 Metabolism of cofactors and vitamins - 00770 Pantothenate and CoA biosynthesis [PATH:hsa00770]","0.466319658067883","0.511447366913162",2342]
["09107 Glycan biosynthesis and metabolism - 00512 Mucin type O-glycan biosynthesis [PATH:hsa00512]","0.540908926385857","0.574715734284973",2371]
["09107 Glycan biosynthesis and metabolism - 00603 Glycosphingolipid biosynthesis - globo and isoglobo series [PATH:hsa00603]","0.609672108955316","0.63781082167633",2396]
["09105 Amino acid metabolism - 00310 Lysine degradation [PATH:hsa00310]","0.317850087136096","0.366335693648381",2275]
["09107 Glycan biosynthesis and metabolism - 00533 Glycosaminoglycan biosynthesis - keratan sulfate [PATH:hsa00533]","0.444388647652593","0.495384066235677",2333]
["09106 Metabolism of other amino acids - 00450 Selenocompound metabolism [PATH:hsa00450]","0.302459762631198","0.354607997567611",2267]
["09104 Nucleotide metabolism - 00240 Pyrimidine metabolism [PATH:hsa00240]","0.13378611040901","0.16540828196023",2151]
["09101 Carbohydrate metabolism - 00500 Starch and sucrose metabolism [PATH:hsa00500]","0.202902042523474","0.246381051635648",2207]
["09103 Lipid metabolism - 00600 Sphingolipid metabolism [PATH:hsa00600]","0.00493869442029","0.007300678708254",1826]
["09103 Lipid metabolism - 00564 Glycerophospholipid metabolism [PATH:hsa00564]","0.000470330039691","0.000780059578023",1656]
["09103 Lipid metabolism - 00062 Fatty acid elongation [PATH:hsa00062]","0.044230799800417","0.05897439973389",2024]
["09101 Carbohydrate metabolism - 00052 Galactose metabolism [PATH:hsa00052]","0.072177930856517","0.094386524966214",2077]
["09108 Metabolism of cofactors and vitamins - 00760 Nicotinate and nicotinamide metabolism [PATH:hsa00760]","0.005192189359662","0.007512103754405",1830]
["09101 Carbohydrate metabolism - 00520 Amino sugar and nucleotide sugar metabolism [PATH:hsa00520]","0.00125225214394","0.00189229212862",1723]
["09103 Lipid metabolism - 00561 Glycerolipid metabolism [PATH:hsa00561]","0.001150327226157","0.001777778440425",1717]
["09103 Lipid metabolism - 00061 Fatty acid biosynthesis [PATH:hsa00061]","0.013588783957974","0.018857904268209",1911]
["09105 Amino acid metabolism - 00330 Arginine and proline metabolism [PATH:hsa00330]","6.18517855328567E-05","0.000116831150451",1530]
["09102 Energy metabolism - 00920 Sulfur metabolism [PATH:hsa00920]","0.027410600755075","0.037278417026902",1976]
["09105 Amino acid metabolism - 00380 Tryptophan metabolism [PATH:hsa00380]","0.000357315265033","0.000607435950555",1638]
["09105 Amino acid metabolism - 00260 Glycine, serine and threonine metabolism [PATH:hsa00260]","0.000571816110699","0.00092579751256",1669]
["09103 Lipid metabolism - 00565 Ether lipid metabolism [PATH:hsa00565]","7.11840358624177E-07","2.5476391782339E-06",1294]
["09107 Glycan biosynthesis and metabolism - 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis [PATH:hsa00563]","2.97802546632724E-05","5.95605093265447E-05",1488]
["09105 Amino acid metabolism - 00270 Cysteine and methionine metabolism [PATH:hsa00270]","1.42086293619978E-05","2.92783877762379E-05",1447]
["09101 Carbohydrate metabolism - 00010 Glycolysis / Gluconeogenesis [PATH:hsa00010]","6.50983047206E-05","0.000119640127595",1533]
["09105 Amino acid metabolism - 00280 Valine, leucine and isoleucine degradation [PATH:hsa00280]","7.68427150829578E-06","1.80182918125556E-05",1414]
["09103 Lipid metabolism - 01040 Biosynthesis of unsaturated fatty acids [PATH:hsa01040]","4.94737773393326E-05","9.61204816878462E-05",1517]
["09106 Metabolism of other amino acids - 00410 beta-Alanine metabolism [PATH:hsa00410]","0.000142471783327","0.000248412340159",1580]
["09103 Lipid metabolism - 00071 Fatty acid degradation [PATH:hsa00071]","5.56154598217367E-06","1.4277571233784E-05",1397]
["09101 Carbohydrate metabolism - 00640 Propanoate metabolism [PATH:hsa00640]","5.66903563694363E-06","1.4277571233784E-05",1398]
["09101 Carbohydrate metabolism - 00051 Fructose and mannose metabolism [PATH:hsa00051]","2.40584274265437E-06","7.43624120456806E-06",1354]
["09105 Amino acid metabolism - 00250 Alanine, aspartate and glutamate metabolism [PATH:hsa00250]","3.66887147026831E-09","1.91910199983266E-08",1061]
["09105 Amino acid metabolism - 00340 Histidine metabolism [PATH:hsa00340]","8.3897078357697E-05","0.000150131613903",1548]
["09101 Carbohydrate metabolism - 00650 Butanoate metabolism [PATH:hsa00650]","4.76915386819239E-06","1.29720985214833E-05",1389]
["09107 Glycan biosynthesis and metabolism - 00601 Glycosphingolipid biosynthesis - lacto and neolacto series [PATH:hsa00601]","1.37250523672759E-06","4.44430267130838E-06",1326]
["09101 Carbohydrate metabolism - 00620 Pyruvate metabolism [PATH:hsa00620]","1.34276786637556E-08","5.70676343209611E-08",1115]
["09103 Lipid metabolism - 00590 Arachidonic acid metabolism [PATH:hsa00590]","7.04786137361268E-08","2.66252540780924E-07",1187]
["09103 Lipid metabolism - 00591 Linoleic acid metabolism [PATH:hsa00591]","9.9944093408822E-06","2.23360972836115E-05",1428]
["09101 Carbohydrate metabolism - 00020 Citrate cycle (TCA cycle) [PATH:hsa00020]","6.85917094262722E-06","1.66579865749518E-05",1408]
["09108 Metabolism of cofactors and vitamins - 00860 Porphyrin and chlorophyll metabolism [PATH:hsa00860]","8.93502763651015E-12","8.67974113260986E-11",832]
["09101 Carbohydrate metabolism - 00630 Glyoxylate and dicarboxylate metabolism [PATH:hsa00630]","4.6922995626588E-08","1.87691982506352E-07",1169]
["09109 Metabolism of terpenoids and polyketides - 00900 Terpenoid backbone biosynthesis [PATH:hsa00900]","1.03188219880914E-06","3.50839947595109E-06",1312]
["09103 Lipid metabolism - 00592 alpha-Linolenic acid metabolism [PATH:hsa00592]","2.81792015870096E-06","7.9841071163194E-06",1362]
["09111 Xenobiotics biodegradation and metabolism - 00983 Drug metabolism - other enzymes [PATH:hsa00983]","1.10829793144252E-10","7.53642593380912E-10",924]
["09105 Amino acid metabolism - 00220 Arginine biosynthesis [PATH:hsa00220]","2.81792015870096E-06","7.9841071163194E-06",1362]
["09102 Energy metabolism - 00190 Oxidative phosphorylation [PATH:hsa00190]","1.13786953465657E-08","5.15834189044313E-08",1108]
["09105 Amino acid metabolism - 00350 Tyrosine metabolism [PATH:hsa00350]","5.68314851780348E-09","2.76038642293312E-08",1079]
["09108 Metabolism of cofactors and vitamins - 00790 Folate biosynthesis [PATH:hsa00790]","5.08485606999525E-11","3.8418912528853E-10",895]
["09101 Carbohydrate metabolism - 00030 Pentose phosphate pathway [PATH:hsa00030]","4.33333843031099E-10","2.45555844384289E-09",976]
["09108 Metabolism of cofactors and vitamins - 00830 Retinol metabolism [PATH:hsa00830]","7.40157692501078E-14","1.00661446180147E-12",669]
["09103 Lipid metabolism - 00100 Steroid biosynthesis [PATH:hsa00100]","1.52395193981963E-10","9.42079380979406E-10",936]
["09106 Metabolism of other amino acids - 00480 Glutathione metabolism [PATH:hsa00480]","3.10765967975142E-18","7.04402860743656E-17",365]
["09101 Carbohydrate metabolism - 00053 Ascorbate and aldarate metabolism [PATH:hsa00053]","3.87476737117576E-11","3.29355226549939E-10",885]
["09101 Carbohydrate metabolism - 00040 Pentose and glucuronate interconversions [PATH:hsa00040]","9.5049132216862E-13","1.07722349845777E-11",754]
["09103 Lipid metabolism - 00140 Steroid hormone biosynthesis [PATH:hsa00140]","5.48118811728682E-18","9.3180197993876E-17",381]
["09111 Xenobiotics biodegradation and metabolism - 00982 Drug metabolism - cytochrome P450 [PATH:hsa00982]","1.31648991947682E-18","4.47606572622117E-17",341]
["09111 Xenobiotics biodegradation and metabolism - 00980 Metabolism of xenobiotics by cytochrome P450 [PATH:hsa00980]","9.90476230837351E-21","6.73523836969399E-19",209]

{"sheet":"Supplementary_Table3","index":2,"n_rows":75,"n_cols":4,"rows_kept":75,"merged":[[0,0,0,8]]}
["MPS1 vs. MPS2 differential testing results on the KEGG metabolic pathways GSVA enrichment scores for the TCGA dataset HPV-negative cases (n=241). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["09107 Glycan biosynthesis and metabolism - 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate [PATH:hsa00532]","3.1709818211682E-14","1.05218942247854E-13",11367]
["09107 Glycan biosynthesis and metabolism - 00511 Other glycan degradation [PATH:hsa00511]","8.72574470125957E-10","1.87346871527044E-09",10577]
["09107 Glycan biosynthesis and metabolism - 00604 Glycosphingolipid biosynthesis - ganglio series [PATH:hsa00604]","1.25539781034405E-06","2.08281909443445E-06",9882]
["09107 Glycan biosynthesis and metabolism - 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin [PATH:hsa00534]","2.55762387913882E-08","5.0461227885712E-08",10273]
["09107 Glycan biosynthesis and metabolism - 00515 Mannose type O-glycan biosynthesis [PATH:hsa00515]","6.93918328294695E-06","1.05533412428152E-05",9692]
["09107 Glycan biosynthesis and metabolism - 00514 Other types of O-glycan biosynthesis [PATH:hsa00514]","2.75450874037412E-08","5.29155626440291E-08",10266]
["09107 Glycan biosynthesis and metabolism - 00531 Glycosaminoglycan degradation [PATH:hsa00531]","0.000782382928383","0.000951899229533",9077]
["09107 Glycan biosynthesis and metabolism - 00513 Various types of N-glycan biosynthesis [PATH:hsa00513]","0.000118744202531","0.000169967191858",9342]
["09107 Glycan biosynthesis and metabolism - 00533 Glycosaminoglycan biosynthesis - keratan sulfate [PATH:hsa00533]","0.008199758288157","0.009501307222785",8690]
["09101 Carbohydrate metabolism - 00562 Inositol phosphate metabolism [PATH:hsa00562]","0.000397230594537","0.000517818453593",9176]
["09107 Glycan biosynthesis and metabolism - 00603 Glycosphingolipid biosynthesis - globo and isoglobo series [PATH:hsa00603]","0.045636610322473","0.049723470948366",8341]
["09107 Glycan biosynthesis and metabolism - 00512 Mucin type O-glycan biosynthesis [PATH:hsa00512]","0.157689330395103","0.169284134100626",8024]
["09107 Glycan biosynthesis and metabolism - 00510 N-Glycan biosynthesis [PATH:hsa00510]","0.261551634820384","0.27671404843316",7867]
["09103 Lipid metabolism - 00600 Sphingolipid metabolism [PATH:hsa00600]","0.823770448624247","0.823770448624247",7138]
["09104 Nucleotide metabolism - 00230 Purine metabolism [PATH:hsa00230]","0.356900868190561","0.366954413773393",6760]
["09105 Amino acid metabolism - 00310 Lysine degradation [PATH:hsa00310]","0.493515906307181","0.500370293894781",6888]
["09103 Lipid metabolism - 00561 Glycerolipid metabolism [PATH:hsa00561]","0.04122642005863","0.045598919155758",6154]
["09103 Lipid metabolism - 00120 Primary bile acid biosynthesis [PATH:hsa00120]","0.272703625616191","0.284390923856885",6665]
["09103 Lipid metabolism - 00564 Glycerophospholipid metabolism [PATH:hsa00564]","0.009289146142544","0.010595432318839",5851]
["09101 Carbohydrate metabolism - 00500 Starch and sucrose metabolism [PATH:hsa00500]","0.041043160524572","0.045598919155758",6153]
["09108 Metabolism of cofactors and vitamins - 00760 Nicotinate and nicotinamide metabolism [PATH:hsa00760]","0.000510121276346","0.000653313213566",5378]
["09103 Lipid metabolism - 00565 Ether lipid metabolism [PATH:hsa00565]","8.9626257056797E-05","0.000130854335303",5139]
["09108 Metabolism of cofactors and vitamins - 00770 Pantothenate and CoA biosynthesis [PATH:hsa00770]","0.000162540301207","0.000215735308875",5218]
["09106 Metabolism of other amino acids - 00450 Selenocompound metabolism [PATH:hsa00450]","0.000613701675553","0.000772417626127",5405]
["09107 Glycan biosynthesis and metabolism - 00601 Glycosphingolipid biosynthesis - lacto and neolacto series [PATH:hsa00601]","0.000808954207064","0.000968092739601",5446]
["09102 Energy metabolism - 00910 Nitrogen metabolism [PATH:hsa00910]","0.001391931487132","0.001638887073559",5529]
["09104 Nucleotide metabolism - 00240 Pyrimidine metabolism [PATH:hsa00240]","2.78730247131375E-06","4.42332783491094E-06",4723]
["09101 Carbohydrate metabolism - 00052 Galactose metabolism [PATH:hsa00052]","0.000136962532844","0.00019148923832",5195]
["09108 Metabolism of cofactors and vitamins - 00670 One carbon pool by folate [PATH:hsa00670]","0.00066126214814","0.000818171810411",5416]
["09105 Amino acid metabolism - 00380 Tryptophan metabolism [PATH:hsa00380]","9.30342620632305E-07","1.57941886758508E-06",4604]
["09103 Lipid metabolism - 00590 Arachidonic acid metabolism [PATH:hsa00590]","1.59749261699165E-06","2.59148802311979E-06",4662]
["09105 Amino acid metabolism - 00340 Histidine metabolism [PATH:hsa00340]","0.000139026433301","0.00019148923832",5197]
["09101 Carbohydrate metabolism - 00520 Amino sugar and nucleotide sugar metabolism [PATH:hsa00520]","1.53569260151578E-09","3.2030159974472E-09",3990]
["09108 Metabolism of cofactors and vitamins - 00730 Thiamine metabolism [PATH:hsa00730]","2.96350177920064E-07","5.27647877760114E-07",4485]
["09101 Carbohydrate metabolism - 00053 Ascorbate and aldarate metabolism [PATH:hsa00053]","0.00015431524569","0.000208611350655",5211]
["09107 Glycan biosynthesis and metabolism - 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis [PATH:hsa00563]","3.60353259610157E-07","6.2632828456051E-07",4505]
["09103 Lipid metabolism - 01040 Biosynthesis of unsaturated fatty acids [PATH:hsa01040]","3.51051652071299E-08","6.57096682082176E-08",4275]
["09105 Amino acid metabolism - 00330 Arginine and proline metabolism [PATH:hsa00330]","3.28829668033741E-15","1.2633981982349E-14",2995]
["09103 Lipid metabolism - 00591 Linoleic acid metabolism [PATH:hsa00591]","1.98671254864172E-05","2.95979624593562E-05",4950]
["09105 Amino acid metabolism - 00260 Glycine, serine and threonine metabolism [PATH:hsa00260]","8.61849006558328E-12","2.58224562081765E-11",3564]
["09106 Metabolism of other amino acids - 00410 beta-Alanine metabolism [PATH:hsa00410]","1.47105888510535E-10","3.35585308164658E-10",3791]
["09105 Amino acid metabolism - 00250 Alanine, aspartate and glutamate metabolism [PATH:hsa00250]","2.35915039135057E-11","6.15064209173541E-11",3643]
["09103 Lipid metabolism - 00592 alpha-Linolenic acid metabolism [PATH:hsa00592]","3.71427307325639E-06","5.76897732654716E-06",4755]
["09102 Energy metabolism - 00920 Sulfur metabolism [PATH:hsa00920]","5.38561909506518E-08","9.82875484849395E-08",4316]
["09103 Lipid metabolism - 00062 Fatty acid elongation [PATH:hsa00062]","1.74123534025003E-11","4.70778443845378E-11",3619]
["09103 Lipid metabolism - 00061 Fatty acid biosynthesis [PATH:hsa00061]","1.21875828861085E-11","3.42189827186893E-11",3591]
["09108 Metabolism of cofactors and vitamins - 00830 Retinol metabolism [PATH:hsa00830]","1.28719989139999E-10","3.03114813136126E-10",3780]
["09108 Metabolism of cofactors and vitamins - 00860 Porphyrin and chlorophyll metabolism [PATH:hsa00860]","1.30596271424647E-15","5.29640434111068E-15",2933]
["09103 Lipid metabolism - 00100 Steroid biosynthesis [PATH:hsa00100]","4.96421281091725E-09","1.00663204221378E-08",4094]
["09105 Amino acid metabolism - 00360 Phenylalanine metabolism [PATH:hsa00360]","1.0592340666403E-10","2.57746956215807E-10",3764]
["09105 Amino acid metabolism - 00220 Arginine biosynthesis [PATH:hsa00220]","4.69746920309683E-11","1.18246638560713E-10",3698]
["09105 Amino acid metabolism - 00270 Cysteine and methionine metabolism [PATH:hsa00270]","8.7747062766904E-19","6.40553558198399E-18",2470]
["09111 Xenobiotics biodegradation and metabolism - 00983 Drug metabolism - other enzymes [PATH:hsa00983]","8.31321598435939E-17","3.56979274622491E-16",2753]
["09111 Xenobiotics biodegradation and metabolism - 00982 Drug metabolism - cytochrome P450 [PATH:hsa00982]","2.95433662322955E-10","6.53535071199264E-10",3849]
["09103 Lipid metabolism - 00071 Fatty acid degradation [PATH:hsa00071]","1.59246690177085E-19","1.93750139715454E-18",2368]
["09103 Lipid metabolism - 00140 Steroid hormone biosynthesis [PATH:hsa00140]","8.53854928145513E-15","2.96816236926774E-14",3060]
["09101 Carbohydrate metabolism - 00010 Glycolysis / Gluconeogenesis [PATH:hsa00010]","4.59306523702256E-18","2.57918278694344E-17",2571]
["09106 Metabolism of other amino acids - 00480 Glutathione metabolism [PATH:hsa00480]","3.45309344762049E-19","3.60108316680422E-18",2414]
["09105 Amino acid metabolism - 00350 Tyrosine metabolism [PATH:hsa00350]","2.47513451801077E-17","1.12928012384241E-16",2676]
["09101 Carbohydrate metabolism - 00040 Pentose and glucuronate interconversions [PATH:hsa00040]","1.78715854254056E-13","5.67228580893308E-13",3274]
["09108 Metabolism of cofactors and vitamins - 00790 Folate biosynthesis [PATH:hsa00790]","2.01329954464301E-17","9.7980577839293E-17",2663]
["09101 Carbohydrate metabolism - 00051 Fructose and mannose metabolism [PATH:hsa00051]","3.71888655239616E-18","2.26232265270766E-17",2558]
["09105 Amino acid metabolism - 00280 Valine, leucine and isoleucine degradation [PATH:hsa00280]","5.0924525781752E-20","7.43498076413579E-19",2301]
["09109 Metabolism of terpenoids and polyketides - 00900 Terpenoid backbone biosynthesis [PATH:hsa00900]","8.84330692060839E-12","2.58224562081765E-11",3566]
["09101 Carbohydrate metabolism - 00640 Propanoate metabolism [PATH:hsa00640]","6.72946371010843E-19","5.45834278708795E-18",2454]
["09101 Carbohydrate metabolism - 00030 Pentose phosphate pathway [PATH:hsa00030]","4.9808326548256E-18","2.59714845573049E-17",2576]
["09101 Carbohydrate metabolism - 00630 Glyoxylate and dicarboxylate metabolism [PATH:hsa00630]","4.26416428827569E-23","1.55641996522063E-21",1903]
["09101 Carbohydrate metabolism - 00650 Butanoate metabolism [PATH:hsa00650]","6.09065727742795E-19","5.45834278708795E-18",2448]
["09108 Metabolism of cofactors and vitamins - 00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:hsa00130]","7.82328566208839E-15","2.85549926666226E-14",3054]
["09101 Carbohydrate metabolism - 00620 Pyruvate metabolism [PATH:hsa00620]","2.86807871904413E-26","2.09369746490221E-24",1521]
["09111 Xenobiotics biodegradation and metabolism - 00980 Metabolism of xenobiotics by cytochrome P450 [PATH:hsa00980]","1.72525600148793E-18","1.14494261916926E-17",2511]
["09101 Carbohydrate metabolism - 00020 Citrate cycle (TCA cycle) [PATH:hsa00020]","3.68461120572806E-22","8.96588726727161E-21",2021]
["09102 Energy metabolism - 00190 Oxidative phosphorylation [PATH:hsa00190]","6.44235660729491E-22","1.17573008083132E-20",2052]

{"sheet":"Supplementary_Table4","index":3,"n_rows":76,"n_cols":4,"rows_kept":76}
["MPS1 vs. MPS2 differential testing results on the KEGG metabolic pathways GSVA enrichment scores for the GSE41613 dataset HPV-negative cases (n=96). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["09105 Amino acid metabolism - 00350 Tyrosine metabolism [PATH:hsa00350]","9.30797469584594e-15","6.887901274926e-13",93]
["09105 Amino acid metabolism - 00360 Phenylalanine metabolism [PATH:hsa00360]","7.19043843225091e-14","2.66046221993284e-12",129]
["09111 Xenobiotics biodegradation and metabolism - 00980 Metabolism of xenobiotics by cytochrome P450 [PATH:hsa00980]","7.55564508894552e-13","1.86372578860656e-11",172]
["09101 Carbohydrate metabolism - 00640 Propanoate metabolism [PATH:hsa00640]","1.04095886396981e-12","1.92577389834415e-11",178]
["09103 Lipid metabolism - 00140 Steroid hormone biosynthesis [PATH:hsa00140]","2.18239186816512e-12","2.69161663740365e-11",192]
["09106 Metabolism of other amino acids - 00410 beta-Alanine metabolism [PATH:hsa00410]","1.96462451276703e-12","2.69161663740365e-11",190]
["09103 Lipid metabolism - 00071 Fatty acid degradation [PATH:hsa00071]","1.02973386520693e-11","1.00223884181282e-10",222]
["09105 Amino acid metabolism - 00280 Valine, leucine and isoleucine degradation [PATH:hsa00280]","1.08350145060845e-11","1.00223884181282e-10",223]
["09111 Xenobiotics biodegradation and metabolism - 00982 Drug metabolism - cytochrome P450 [PATH:hsa00982]","1.39639529146017e-11","1.14814723964503e-10",228]
["09101 Carbohydrate metabolism - 00620 Pyruvate metabolism [PATH:hsa00620]","2.08548674816816e-10","1.54326019364444e-09",283]
["09108 Metabolism of cofactors and vitamins - 00830 Retinol metabolism [PATH:hsa00830]","1.28802089648608e-09","8.66486784908818e-09",322]
["09103 Lipid metabolism - 00590 Arachidonic acid metabolism [PATH:hsa00590]","1.47675780939096e-09","9.10667315791091e-09",325]
["09102 Energy metabolism - 00190 Oxidative phosphorylation [PATH:hsa00190]","6.1659289835582e-09","3.50983649833313e-08",357]
["09108 Metabolism of cofactors and vitamins - 00790 Folate biosynthesis [PATH:hsa00790]","7.67139186769271e-09","4.05487855863758e-08",362]
["09105 Amino acid metabolism - 00340 Histidine metabolism [PATH:hsa00340]","1.28900444457009e-08","6.35908859321246e-08",374]
["09107 Glycan biosynthesis and metabolism - 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate [PATH:hsa00532]","2.768116639827e-08","1.28025394591999e-07",1908]
["09106 Metabolism of other amino acids - 00480 Glutathione metabolism [PATH:hsa00480]","3.41256091360313e-08","1.48546769180371e-07",397]
["09101 Carbohydrate metabolism - 00650 Butanoate metabolism [PATH:hsa00650]","4.03077353395614e-08","1.65709578618197e-07",401]
["09103 Lipid metabolism - 00591 Linoleic acid metabolism [PATH:hsa00591]","7.17143291575581e-08","2.65343017882965e-07",415]
["09103 Lipid metabolism - 00592 alpha-Linolenic acid metabolism [PATH:hsa00592]","6.88463251755888e-08","2.65343017882965e-07",414]
["09101 Carbohydrate metabolism - 00030 Pentose phosphate pathway [PATH:hsa00030]","8.7880308385343e-08","2.95597400932517e-07",420]
["09101 Carbohydrate metabolism - 00630 Glyoxylate and dicarboxylate metabolism [PATH:hsa00630]","8.7880308385343e-08","2.95597400932517e-07",420]
["09105 Amino acid metabolism - 00260 Glycine, serine and threonine metabolism [PATH:hsa00260]","2.11648803528571e-07","6.80957020048445e-07",442]
["09103 Lipid metabolism - 00565 Ether lipid metabolism [PATH:hsa00565]","2.28967771675764e-07","7.05983962666939e-07",444]
["09105 Amino acid metabolism - 00220 Arginine biosynthesis [PATH:hsa00220]","3.51583163611667e-07","1.04068616429053e-06",455]
["09107 Glycan biosynthesis and metabolism - 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin [PATH:hsa00534]","4.97028921337476e-07","1.41462077611435e-06",1836]
["09101 Carbohydrate metabolism - 00010 Glycolysis / Gluconeogenesis [PATH:hsa00010]","2.45183908682931e-06","6.71985527501367e-06",507]
["09101 Carbohydrate metabolism - 00020 Citrate cycle (TCA cycle) [PATH:hsa00020]","3.04012328794448e-06","8.0346115467104e-06",513]
["09101 Carbohydrate metabolism - 00040 Pentose and glucuronate interconversions [PATH:hsa00040]","3.38288291471406e-06","8.63218398927035e-06",516]
["09103 Lipid metabolism - 00061 Fatty acid biosynthesis [PATH:hsa00061]","4.98508852077914e-06","1.22965516845886e-05",527]
["09109 Metabolism of terpenoids and polyketides - 00900 Terpenoid backbone biosynthesis [PATH:hsa00900]","1.48618302752282e-05","3.54766271086093e-05",559]
["09111 Xenobiotics biodegradation and metabolism - 00983 Drug metabolism - other enzymes [PATH:hsa00983]","2.35725058057266e-05","5.45114196757427e-05",573]
["09105 Amino acid metabolism - 00380 Tryptophan metabolism [PATH:hsa00380]","6.12272469905097e-05","0.000137297462948416",603]
["09107 Glycan biosynthesis and metabolism - 00533 Glycosaminoglycan biosynthesis - keratan sulfate [PATH:hsa00533]","8.58846720559024e-05","0.000186925462709905",1686]
["09102 Energy metabolism - 00920 Sulfur metabolism [PATH:hsa00920]","0.000112762049284525","0.000238411189915853",623]
["09103 Lipid metabolism - 00062 Fatty acid elongation [PATH:hsa00062]","0.000134894712457794","0.000277283575607688",629]
["09107 Glycan biosynthesis and metabolism - 00514 Other types of O-glycan biosynthesis [PATH:hsa00514]","0.000170815945629626","0.000332641578331378",1663]
["09107 Glycan biosynthesis and metabolism - 00515 Mannose type O-glycan biosynthesis [PATH:hsa00515]","0.000170815945629626","0.000332641578331378",1663]
["09108 Metabolism of cofactors and vitamins - 00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:hsa00130]","0.00020346870801834","0.000386068830598902",643]
["09101 Carbohydrate metabolism - 00053 Ascorbate and aldarate metabolism [PATH:hsa00053]","0.000303851086516581","0.000562124510055674",657]
["09103 Lipid metabolism - 01040 Biosynthesis of unsaturated fatty acids [PATH:hsa01040]","0.00041349047968546","0.000746299890164",668]
["09101 Carbohydrate metabolism - 00051 Fructose and mannose metabolism [PATH:hsa00051]","0.000461806564000085","0.000794736877581541",672]
["09103 Lipid metabolism - 00100 Steroid biosynthesis [PATH:hsa00100]","0.000461806564000085","0.000794736877581541",672]
["09103 Lipid metabolism - 00564 Glycerophospholipid metabolism [PATH:hsa00564]","0.000751756926166071","0.00126431846673385",690]
["09108 Metabolism of cofactors and vitamins - 00860 Porphyrin and chlorophyll metabolism [PATH:hsa00860]","0.000814056826843785","0.00133867122636534",693]
["09105 Amino acid metabolism - 00250 Alanine, aspartate and glutamate metabolism [PATH:hsa00250]","0.00105800263410383","0.00170200423747137",703]
["09107 Glycan biosynthesis and metabolism - 00604 Glycosphingolipid biosynthesis - ganglio series [PATH:hsa00604]","0.00117329216909423","0.00184731107474411",1593]
["09107 Glycan biosynthesis and metabolism - 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis [PATH:hsa00563]","0.00140337261195907","0.00216353277677023",714]
["09107 Glycan biosynthesis and metabolism - 00510 N-Glycan biosynthesis [PATH:hsa00510]","0.00248407540580558","0.00375146081693088",1563]
["09103 Lipid metabolism - 00561 Glycerolipid metabolism [PATH:hsa00561]","0.00301109938021176","0.0044564270827134",745]
["09103 Lipid metabolism - 00120 Primary bile acid biosynthesis [PATH:hsa00120]","0.00418425019860628","0.00607126499405616",759]
["09107 Glycan biosynthesis and metabolism - 00601 Glycosphingolipid biosynthesis - lacto and neolacto series [PATH:hsa00601]","0.00438212523370259","0.00623610129411522",761]
["09107 Glycan biosynthesis and metabolism - 00513 Various types of N-glycan biosynthesis [PATH:hsa00513]","0.00514327601523638","0.00718117783259419",1532]
["09105 Amino acid metabolism - 00310 Lysine degradation [PATH:hsa00310]","0.00588867772120192","0.00806966946979523",774]
["09104 Nucleotide metabolism - 00230 Purine metabolism [PATH:hsa00230]","0.0127781698277433","0.0171924466773273",1490]
["09108 Metabolism of cofactors and vitamins - 00760 Nicotinate and nicotinamide metabolism [PATH:hsa00760]","0.0194975677346291","0.0257646430779027",831]
["09101 Carbohydrate metabolism - 00500 Starch and sucrose metabolism [PATH:hsa00500]","0.020674489883969","0.0268405658142755",1466]
["09105 Amino acid metabolism - 00330 Arginine and proline metabolism [PATH:hsa00330]","0.023664143876944","0.0301921835671354",841]
["09106 Metabolism of other amino acids - 00450 Selenocompound metabolism [PATH:hsa00450]","0.0440954140130109","0.0553061124908951",875]
["09105 Amino acid metabolism - 00270 Cysteine and methionine metabolism [PATH:hsa00270]","0.0464610260528005","0.0563625561952006",878]
["09108 Metabolism of cofactors and vitamins - 00770 Pantothenate and CoA biosynthesis [PATH:hsa00770]","0.0464610260528005","0.0563625561952006",878]
["09104 Nucleotide metabolism - 00240 Pyrimidine metabolism [PATH:hsa00240]","0.0640495615528947","0.076446250885713",1403]
["09108 Metabolism of cofactors and vitamins - 00730 Thiamine metabolism [PATH:hsa00730]","0.0717822411700373","0.0843156483584566",904]
["09107 Glycan biosynthesis and metabolism - 00603 Glycosphingolipid biosynthesis - globo and isoglobo series [PATH:hsa00603]","0.0981647532111842","0.113502995900432",924]
["09106 Metabolism of other amino acids - 00430 Taurine and hypotaurine metabolism [PATH:hsa00430]","0.110679870156801","0.126004775255435",932]
["09108 Metabolism of cofactors and vitamins - 00670 One carbon pool by folate [PATH:hsa00670]","0.28592811155353","0.320586064469109",1004]
["09107 Glycan biosynthesis and metabolism - 00512 Mucin type O-glycan biosynthesis [PATH:hsa00512]","0.316782891241811","0.349879611222299",1013]
["09103 Lipid metabolism - 00600 Sphingolipid metabolism [PATH:hsa00600]","0.392877377008518","0.427543027921035",1033]
["09101 Carbohydrate metabolism - 00052 Galactose metabolism [PATH:hsa00052]","0.434760808809959","0.466265215245463",1257]
["09101 Carbohydrate metabolism - 00562 Inositol phosphate metabolism [PATH:hsa00562]","0.47004927080739","0.496909229139241",1051]
["09102 Energy metabolism - 00910 Nitrogen metabolism [PATH:hsa00910]","0.651960050067232","0.670070051457988",1088]
["09107 Glycan biosynthesis and metabolism - 00511 Other glycan degradation [PATH:hsa00511]","0.646683100839916","0.670070051457988",1213]
["09101 Carbohydrate metabolism - 00520 Amino sugar and nucleotide sugar metabolism [PATH:hsa00520]","0.673240402465927","0.682462873732584",1092]
["09107 Glycan biosynthesis and metabolism - 00531 Glycosaminoglycan degradation [PATH:hsa00531]","0.777668283438917","0.777668283438917",1189]

{"sheet":"Supplementary_Table5","index":4,"n_rows":75,"n_cols":4,"rows_kept":75}
["MPS1 vs. MPS2 differential testing results on the KEGG metabolic pathways GSVA enrichment scores for the GSE65858 dataset HPV-negative cases (n=176). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["09103 Lipid metabolism - 00140 Steroid hormone biosynthesis [PATH:hsa00140]","4.7600689131718e-24","3.47485030661541e-22",413]
["09111 Xenobiotics biodegradation and metabolism - 00980 Metabolism of xenobiotics by cytochrome P450 [PATH:hsa00980]","6.73561832647014e-23","2.4585006891616e-21",501]
["09111 Xenobiotics biodegradation and metabolism - 00982 Drug metabolism - cytochrome P450 [PATH:hsa00982]","1.19529035744397e-20","2.90853986978032e-19",680]
["09108 Metabolism of cofactors and vitamins - 00830 Retinol metabolism [PATH:hsa00830]","2.69333294843019e-20","4.9153326308851e-19",709]
["09106 Metabolism of other amino acids - 00480 Glutathione metabolism [PATH:hsa00480]","7.10905474837051e-20","1.03792199326209e-18",744]
["09111 Xenobiotics biodegradation and metabolism - 00983 Drug metabolism - other enzymes [PATH:hsa00983]","8.62090922135051e-20","1.04887728859765e-18",751]
["09105 Amino acid metabolism - 00350 Tyrosine metabolism [PATH:hsa00350]","1.90757458662331e-19","1.98932778319288e-18",780]
["09105 Amino acid metabolism - 00360 Phenylalanine metabolism [PATH:hsa00360]","7.17750362804434e-19","6.54947206059046e-18",829]
["09101 Carbohydrate metabolism - 00620 Pyruvate metabolism [PATH:hsa00620]","4.35899935437901e-18","3.53563280966298e-17",897]
["09101 Carbohydrate metabolism - 00040 Pentose and glucuronate interconversions [PATH:hsa00040]","9.78721360403499e-18","7.14466593094554e-17",928]
["09101 Carbohydrate metabolism - 00053 Ascorbate and aldarate metabolism [PATH:hsa00053]","7.10657726533912e-16","4.71618309427051e-15",1098]
["09108 Metabolism of cofactors and vitamins - 00790 Folate biosynthesis [PATH:hsa00790]","1.92292434600288e-15","1.16977897715175e-14",1139]
["09103 Lipid metabolism - 00071 Fatty acid degradation [PATH:hsa00071]","2.69220026460161e-15","1.51177399473782e-14",1153]
["09106 Metabolism of other amino acids - 00410 beta-Alanine metabolism [PATH:hsa00410]","1.06560518008808e-14","5.55636986760216e-14",1211]
["09107 Glycan biosynthesis and metabolism - 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate [PATH:hsa00532]","1.95555328419441e-14","9.51702598307947e-14",6363]
["09105 Amino acid metabolism - 00280 Valine, leucine and isoleucine degradation [PATH:hsa00280]","7.76082290739902e-14","3.5408754515008e-13",1297]
["09101 Carbohydrate metabolism - 00640 Propanoate metabolism [PATH:hsa00640]","9.09609410308361e-14","3.9059698207359e-13",1304]
["09105 Amino acid metabolism - 00340 Histidine metabolism [PATH:hsa00340]","1.74784958925032e-13","7.08850111195961e-13",1333]
["09101 Carbohydrate metabolism - 00020 Citrate cycle (TCA cycle) [PATH:hsa00020]","7.85326347198602e-13","3.01730649186831e-12",1401]
["09101 Carbohydrate metabolism - 00650 Butanoate metabolism [PATH:hsa00650]","5.98727177438052e-12","2.18535419764889e-11",1496]
["09108 Metabolism of cofactors and vitamins - 00860 Porphyrin and chlorophyll metabolism [PATH:hsa00860]","1.16588998477306e-11","4.05285566135398e-11",1528]
["09101 Carbohydrate metabolism - 00630 Glyoxylate and dicarboxylate metabolism [PATH:hsa00630]","4.13386192302568e-11","1.37169054718579e-10",1590]
["09102 Energy metabolism - 00190 Oxidative phosphorylation [PATH:hsa00190]","8.15845995414052e-11","2.58942424631416e-10",1624]
["09101 Carbohydrate metabolism - 00010 Glycolysis / Gluconeogenesis [PATH:hsa00010]","9.3724034574073e-11","2.85077271829472e-10",1631]
["09103 Lipid metabolism - 00590 Arachidonic acid metabolism [PATH:hsa00590]","2.90976591939822e-10","8.16972738907961e-10",1689]
["09108 Metabolism of cofactors and vitamins - 00770 Pantothenate and CoA biosynthesis [PATH:hsa00770]","2.85419207361689e-10","8.16972738907961e-10",1688]
["09101 Carbohydrate metabolism - 00030 Pentose phosphate pathway [PATH:hsa00030]","3.83072737393142e-09","1.03571517887775e-08",1827]
["09105 Amino acid metabolism - 00270 Cysteine and methionine metabolism [PATH:hsa00270]","4.84197463095863e-09","1.26237195735707e-08",1840]
["09109 Metabolism of terpenoids and polyketides - 00900 Terpenoid backbone biosynthesis [PATH:hsa00900]","6.00303600424038e-09","1.51110906313637e-08",1852]
["09103 Lipid metabolism - 00591 Linoleic acid metabolism [PATH:hsa00591]","6.44712738920076e-09","1.54549215208579e-08",1856]
["09105 Amino acid metabolism - 00260 Glycine, serine and threonine metabolism [PATH:hsa00260]","6.56304886502185e-09","1.54549215208579e-08",1857]
["09103 Lipid metabolism - 00100 Steroid biosynthesis [PATH:hsa00100]","1.03993136916338e-08","2.37234343590396e-08",1883]
["09103 Lipid metabolism - 00561 Glycerolipid metabolism [PATH:hsa00561]","5.40766108998433e-08","1.19624018051169e-07",1979]
["09103 Lipid metabolism - 00592 alpha-Linolenic acid metabolism [PATH:hsa00592]","1.08479593383432e-07","2.32912068146781e-07",2021]
["09103 Lipid metabolism - 00564 Glycerophospholipid metabolism [PATH:hsa00564]","1.50309807604695e-07","3.13503313004079e-07",2041]
["09105 Amino acid metabolism - 00380 Tryptophan metabolism [PATH:hsa00380]","4.10517215985385e-07","8.32437687970363e-07",2104]
["09105 Amino acid metabolism - 00220 Arginine biosynthesis [PATH:hsa00220]","1.31798229896429e-06","2.60034345471333e-06",2180]
["09105 Amino acid metabolism - 00330 Arginine and proline metabolism [PATH:hsa00330]","2.80371283928047e-06","5.38607992809143e-06",2231]
["09105 Amino acid metabolism - 00250 Alanine, aspartate and glutamate metabolism [PATH:hsa00250]","8.51797740701791e-06","1.59439064285207e-05",2309]
["09107 Glycan biosynthesis and metabolism - 00511 Other glycan degradation [PATH:hsa00511]","3.59381605855937e-05","6.55871430687086e-05",5184]
["09103 Lipid metabolism - 01040 Biosynthesis of unsaturated fatty acids [PATH:hsa01040]","4.47694565152676e-05","7.97114713564521e-05",2433]
["09107 Glycan biosynthesis and metabolism - 00515 Mannose type O-glycan biosynthesis [PATH:hsa00515]","9.07342257681741e-05","0.000157704725739922",5111]
["09103 Lipid metabolism - 00062 Fatty acid elongation [PATH:hsa00062]","9.30066102791811e-05","0.000157894943032098",2491]
["09107 Glycan biosynthesis and metabolism - 00601 Glycosphingolipid biosynthesis - lacto and neolacto series [PATH:hsa00601]","0.000100150558374794","0.00016615888094",2497]
["09103 Lipid metabolism - 00061 Fatty acid biosynthesis [PATH:hsa00061]","0.000120343296812725","0.000195223570385088",2512]
["09102 Energy metabolism - 00920 Sulfur metabolism [PATH:hsa00920]","0.000140891386697081","0.000223588504975803",2525]
["09107 Glycan biosynthesis and metabolism - 00513 Various types of N-glycan biosynthesis [PATH:hsa00513]","0.000257910223438881","0.000400583964064645",5024]
["09107 Glycan biosynthesis and metabolism - 00514 Other types of O-glycan biosynthesis [PATH:hsa00514]","0.000564357836509778","0.000858294209691953",4955]
["09107 Glycan biosynthesis and metabolism - 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin [PATH:hsa00534]","0.000734122841144796","0.00109369321231776",4931]
["09101 Carbohydrate metabolism - 00051 Fructose and mannose metabolism [PATH:hsa00051]","0.00121161716205077","0.00175251054065238",2716]
["09108 Metabolism of cofactors and vitamins - 00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:hsa00130]","0.00122435667908591","0.00175251054065238",2717]
["09107 Glycan biosynthesis and metabolism - 00604 Glycosphingolipid biosynthesis - ganglio series [PATH:hsa00604]","0.00134470682157373","0.00188776149951697",4874]
["09108 Metabolism of cofactors and vitamins - 00760 Nicotinate and nicotinamide metabolism [PATH:hsa00760]","0.00172099141760687","0.0023704221412321",2750]
["09105 Amino acid metabolism - 00310 Lysine degradation [PATH:hsa00310]","0.00478780128329635","0.00647239803112285",2855]
["09103 Lipid metabolism - 00565 Ether lipid metabolism [PATH:hsa00565]","0.00690264563952279","0.00916169330336662",2895]
["09106 Metabolism of other amino acids - 00450 Selenocompound metabolism [PATH:hsa00450]","0.00715467172848544","0.00932662564606137",2899]
["09107 Glycan biosynthesis and metabolism - 00512 Mucin type O-glycan biosynthesis [PATH:hsa00512]","0.011365329427662","0.0145555973371812",2952]
["09108 Metabolism of cofactors and vitamins - 00670 One carbon pool by folate [PATH:hsa00670]","0.0333328429363674","0.0419534057647383",3087]
["09108 Metabolism of cofactors and vitamins - 00730 Thiamine metabolism [PATH:hsa00730]","0.0584778166524603","0.0723539087394848",4434]
["09107 Glycan biosynthesis and metabolism - 00510 N-Glycan biosynthesis [PATH:hsa00510]","0.0647040010935923","0.0787232013305373",4419]
["09101 Carbohydrate metabolism - 00562 Inositol phosphate metabolism [PATH:hsa00562]","0.0803367738379317","0.096140729347033",4386]
["09103 Lipid metabolism - 00120 Primary bile acid biosynthesis [PATH:hsa00120]","0.0917931301858777","0.108079008122082",3235]
["09107 Glycan biosynthesis and metabolism - 00533 Glycosaminoglycan biosynthesis - keratan sulfate [PATH:hsa00533]","0.107104461332582","0.12410516948061",4340]
["09107 Glycan biosynthesis and metabolism - 00603 Glycosphingolipid biosynthesis - globo and isoglobo series [PATH:hsa00603]","0.11241042567891","0.128218141790006",4332]
["09107 Glycan biosynthesis and metabolism - 00531 Glycosaminoglycan degradation [PATH:hsa00531]","0.126582886987856","0.142162319232515",4312]
["09104 Nucleotide metabolism - 00230 Purine metabolism [PATH:hsa00230]","0.193352739670042","0.213859848422925",4236]
["09104 Nucleotide metabolism - 00240 Pyrimidine metabolism [PATH:hsa00240]","0.325051440244865","0.354160524445898",3470]
["09103 Lipid metabolism - 00600 Sphingolipid metabolism [PATH:hsa00600]","0.395476833234394","0.424556012148687",3515]
["09101 Carbohydrate metabolism - 00052 Galactose metabolism [PATH:hsa00052]","0.489295386508658","0.517660336451189",3568]
["09101 Carbohydrate metabolism - 00500 Starch and sucrose metabolism [PATH:hsa00500]","0.500623193192572","0.522078472900825",3574]
["09101 Carbohydrate metabolism - 00520 Amino sugar and nucleotide sugar metabolism [PATH:hsa00520]","0.591875927594607","0.608548488935301",3620]
["09102 Energy metabolism - 00910 Nitrogen metabolism [PATH:hsa00910]","0.798440321950902","0.809529770866887",3714]
["09107 Glycan biosynthesis and metabolism - 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis [PATH:hsa00563]","0.887182630592786","0.887182630592786",3848]

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["MPS1 vs. MPS2 differential gene expression analysis results of the LMU-KKG 08-13 dataset HPV-negative cases (n=50)."]
["gene_symbol","baseMean","log2FoldChange","lfcSE","stat","p.value","adj.p.value"]
["PGD","104.874789136217","-1.5656001972884","0.192478551557577","-8.13389432027222","4.15714983923222e-16","6.05904589068097e-12"]
["AKR1C3","65.1636762505388","-3.77126039563706","0.479595012097985","-7.86342705930095","3.73764026074676e-15","2.7238053400192e-11"]
["AKR1C2","287.852525216569","-3.31651318623906","0.434490404202021","-7.63311031535927","2.29156632318223e-14","1.11331930534604e-10"]
["ME1","55.0429398933434","-1.83109165279477","0.243495213556349","-7.52003140452297","5.47630863909656e-14","1.99542996037081e-10"]
["AKR1B10","136.766552678624","-3.17764121378426","0.450039344642798","-7.060807575183","1.65537697631506e-12","4.82542388595841e-09"]
["ALDH3A1","79.0329410379388","-3.54381593500525","0.510182725526235","-6.94616998517529","3.75336484480644e-12","9.11754876884232e-09"]
["CES1","38.2863027281429","-4.38761493089","0.638095899870973","-6.87610582010823","6.15108159489907e-12","1.2807430606522e-08"]
["DDX3ILA1","9.28472595195725","-3.88112599723164","0.57332850527076","-6.76946281503785","1.29261429414858e-11","2.35498166715194e-08"]
["NQO1","77.3681625643909","-1.92115436896109","0.288363770067166","-6.66225985502137","2.69648703986016e-11","4.36681095621798e-08"]
["UGT1A3","9.62399515601429","-3.72872343814276","0.576438145713876","-6.46855775570684","9.89427005090005e-11","1.44208985991868e-07"]
["PAPLN","124.939549700097","1.29474022868901","0.20571314638922","6.29391096978944","3.09565419893812e-10","3.75992999579359e-07"]
["SRXN1","93.4883574128764","-1.8018831313151","0.286252618589363","-6.29473064803627","3.07934091016191e-10","3.75992999579359e-07"]
["CYP4F3","60.9563702320884","-3.24555018924508","0.529567609180443","-6.12867957363912","8.86113792662246e-10","9.93469886773249e-07"]
["FLG2","34.6462194477534","-3.45666744955666","0.566636685407126","-6.10032413816105","1.05853587186352e-09","1.10201145231506e-06"]
["SCN9A","47.9104342227786","-2.73943668818873","0.451998162238169","-6.06072527955379","1.3550910938312e-09","1.31669684617265e-06"]
["AKR1C1","341.802290976774","-2.73525376138587","0.454205588283632","-6.02206100484572","1.72209958236751e-09","1.47644714194155e-06"]
["UGT1A7","34.1097818026575","-3.45466635668318","0.573338249345866","-6.02552918913867","1.68557192600937e-09","1.47644714194155e-06"]
["GPX2","49.518830178322","-2.36372552855122","0.395794447606126","-5.97210381006525","2.34213411351996e-09","1.89647803914186e-06"]
["GSTA4","47.5264847096559","-1.39337291949727","0.236743990836209","-5.88556826543178","3.96688604508069e-09","3.043019163529e-06"]
["EID3","30.4234502467764","-1.80192351662178","0.313755820288826","-5.74307598489495","9.2971981243447e-09","6.45269822201543e-06"]
["SLC9A3R1","75.628220072417","-1.23432718305681","0.21463772778675","-5.75074659886055","8.8850202617251e-09","6.45269822201543e-06"]
["G6PD","31.169567275795","-1.31673979549671","0.230426063033656","-5.7143700593643","1.10111148290958e-08","7.29486357427599e-06"]
["GSR","82.4741935312106","-1.40995578222323","0.25100106494172","-5.6173298808537","1.93930955707929e-08","1.18058891062949e-05"]
["TMPRSS4","150.9053179626","-1.3873279024429","0.246991287230223","-5.61691028861985","1.94402290601082e-08","1.18058891062949e-05"]
["CYP2C18","21.2516806346297","-2.58419964752137","0.461683835083234","-5.5973362096498","2.17670332293934e-08","1.26901803727364e-05"]
["GCLC","219.134942811818","-1.41053905535587","0.252729749249581","-5.58121495211436","2.38844241492957e-08","1.33890569990764e-05"]
["NMRAL2P","107.844623290178","-2.82390828732163","0.50658305346992","-5.57442312366911","2.48351444805101e-08","1.34063789186457e-05"]
["FAM135A","210.569446497311","-0.931099984283879","0.170170718883186","-5.47156402931478","4.46081116392885e-08","2.21488682633615e-05"]
["PTGR1","53.6881687503695","-1.62203253220827","0.296558305768618","-5.46952319546169","4.51247867542482e-08","2.21488682633615e-05"]
["TALDO1","54.13084375423","-0.995461189913896","0.182061908170627","-5.46770711081946","4.55894372487715e-08","2.21488682633615e-05"]
["NFE2L2","424.453162046252","-0.997676006146562","0.183161217909586","-5.44698281400948","5.1231411095758e-08","2.40870263458281e-05"]
["UPK1B","18.7948074069817","-3.37130660764179","0.630714591649813","-5.34521739670423","9.0308597068254e-08","4.11327438209313e-05"]
["CALB1","30.0103041751159","-2.25922392970131","0.42760074908495","-5.28348917661153","1.26746355422808e-07","5.43331803025716e-05"]
["ZBTB7C","39.5969914110147","-1.86478715535809","0.352662305476333","-5.28774163385385","1.23835720084641e-07","5.43331803025716e-05"]
["FIGN","23.8831255322832","1.65794861585715","0.315701146303464","5.25163951816463","1.50751279757748e-07","6.27771400705478e-05"]
["GLTP","229.679790490246","-1.46233080906113","0.279052315936158","-5.24034643523864","1.60275417389745e-07","6.48892835682092e-05"]
["TMPRSS11A","83.5288204599187","-2.63087257752214","0.502705390342243","-5.23342822270322","1.66394638912472e-07","6.55459962743048e-05"]
["TKT","141.010170697417","-1.06187086299985","0.203799751802506","-5.21036386751277","1.88470628386e-07","7.22884054927881e-05"]
["MACC1","138.143992889713","-1.87837808613331","0.362562163623973","-5.18084420988132","2.2088391905358e-07","8.25482851334854e-05"]
["TXNRD1","175.652372917174","-1.33818541061231","0.258653422095459","-5.17366211423421","2.29549775218481e-07","8.27082424416605e-05"]
["UGT1A10","10.4292991588306","-4.37452578544674","0.845948812267121","-5.17114714508921","2.32661265187518e-07","8.27082424416605e-05"]
["CLDN4","52.6697678122503","-1.38034117619086","0.267454489907231","-5.16103198218747","2.45592214414838e-07","8.32443377929362e-05"]
["UGT1A5","11.7823163937657","-3.10795570363645","0.6021293937937","-5.16160768046026","2.44837988420559e-07","8.32443377929362e-05"]
["CYP4F11","96.5884053451827","-3.12389672466074","0.609636898143372","-5.12419234166183","2.98815828707231e-07","9.89827432592704e-05"]
["COL16A1","234.62234898246","1.33362030223097","0.26109496915429","5.10779777393141","3.25935204246696e-07","0.000105566791153235"]
["EPHX1","31.5664156576438","-1.28873521359008","0.255227633434752","-5.04935612279435","4.43301662677285e-07","0.000137470675181307"]
["TMEM116","42.6460591490513","-1.47009574767239","0.291056070690249","-5.05090219965524","4.3972818222233e-07","0.000137470675181307"]
["MDGA1","69.906373360352","-1.81613044785512","0.364324902321482","-4.98491987861032","6.19874942375041e-07","0.000188222443439921"]
["TTC22","58.0699292805242","-1.02643792610066","0.206147949632084","-4.97913235582774","6.38699545472316e-07","0.00018998052806651"]
["UGT1A4","14.1758370084359","-2.86045774037108","0.58006908859691","-4.93123628995651","8.17108221114798e-07","0.000238187046454964"]
["UGT1A6","37.7299483096018","-2.68240395881418","0.544874254590548","-4.92297798292912","8.52370457014693e-07","0.000243594106097826"]
["KLF5","561.385373019263","-1.12043520455946","0.229571225166274","-4.88055593094454","1.05787205627815e-06","0.000275330093218823"]
["NAA20","77.003543158814","-0.896319827551705","0.183549499337784","-4.8832594520033","1.04346425487258e-06","0.000275330093218823"]
["PARD3","134.227628715954","-0.73170508130371","0.149658866684113","-4.88915289495095","1.01270818734205e-06","0.000275330093218823"]
["PPL","398.489957695153","-1.32332425848186","0.270514731626123","-4.89187502110169","9.98798630560368e-07","0.000275330093218823"]
["UGT1A1","18.3396089154437","-3.00225185270864","0.614473065741449","-4.88589658374366","1.02959233717023e-06","0.000275330093218823"]
["TMPRSS11E","50.9089436357514","-2.47307772263557","0.50744681479545","-4.87357029451935","1.09599244720317e-06","0.000280247191543617"]
["FAM157C","42.8081820897597","-1.23648060678511","0.255680048765899","-4.83604650716111","1.32446946046344e-06","0.000332830041142321"]
["SKIL","572.68350440271","0.621964797905092","0.129530953514481","4.80166926151406","1.57348426251005e-06","0.00038870395128956"]
["EPB41L1","74.4606271067688","-1.25430671864988","0.261618025620726","-4.79442009270523","1.63146076946137e-06","0.00039630901191499"]
["DBI","53.1791637573376","-0.807877214376673","0.169961757222908","-4.75328819598591","2.00134749907501e-06","0.000470478061274487"]
["FNDC3B","482.352584490291","0.66363934596786","0.139551508880241","4.75551537416463","1.9794079501091e-06","0.000470478061274487"]
["KCNT2","11.7926108984293","1.38492284690781","0.291986078462241","4.74311259701687","2.1045921320653e-06","0.000486895719442091"]
["SLC7A11-AS1","31.648178363108","-2.27492363037912","0.481349992279172","-4.7261320595591","2.28836857360745e-06","0.000521140186880135"]
["FAM227A","19.4626030925348","1.37563425532998","0.292395845793763","4.70469835710409","2.54241573198515e-06","0.00057008783528744"]
["LINC02887","18.3126381851484","-1.81910201845556","0.387580177568099","-4.69348569338517","2.68588782394378e-06","0.000593133561120918"]
["TMPRSS11BNL","40.6383697666744","-2.9193247736335","0.628869131112344","-4.64218170236755","3.44749476827667e-06","0.000749958749964663"]
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{"sheet":"Supplementary_Table7","index":6,"n_rows":13405,"n_cols":7,"rows_kept":13405,"merged":[[0,0,0,6]]}
["MPS1 vs. MPS2 differential gene expression analysis results of the LMU-KKG 13-16 dataset HPV-negative cases (n=95)."]
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{"sheet":"Supplementary_Table8","index":7,"n_rows":14776,"n_cols":7,"rows_kept":4500,"cut":true,"merged":[[0,0,0,6]],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["MPS1 vs. MPS2 differential gene expression analysis results of the TCGA dataset HPV-negative cases (n=241)."]
["gene_symbol","baseMean","log2FoldChange","lfcSE","stat","p.value","adj.p.value"]
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["TREM2","872.405946712142","-2.46156289639461e-05","0.156186943072523","-0.000157603628572948","0.999874250498556","0.999874250498556"]

{"sheet":"Supplementary_Table9","index":8,"n_rows":52,"n_cols":4,"rows_kept":52,"merged":[[0,0,0,8]]}
["MPS1 vs. MPS2 differential testing results on the MSigDB hallmarks GSVA enrichment scores for the LMU-KKG cohort HPV-negative cases (n=145). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["EPITHELIAL_MESENCHYMAL_TRANSITION","0.000135662728899","0.000565261370412",3469]
["ANGIOGENESIS","0.000203165568344","0.000725591315513",3444]
["INFLAMMATORY_RESPONSE","8.82267661954075E-05","0.000441133830977",3495]
["IL6_JAK_STAT3_SIGNALING","0.00036285988358","0.001083779032133",3407]
["INTERFERON_ALPHA_RESPONSE","0.001102292254256","0.002900769090147",3332]
["INTERFERON_GAMMA_RESPONSE","0.000470330039691","0.001306472332474",3390]
["PANCREAS_BETA_CELLS","0.01343633699069","0.027992368730603",3136]
["UV_RESPONSE_DN","0.000107747840517","0.000489762911442",3483]
["COMPLEMENT","0.003033036151689","0.007221514646878",3258]
["ALLOGRAFT_REJECTION","0.00295441458881","0.007221514646878",3260]
["TNFA_SIGNALING_VIA_NFKB","0.03359477379763","0.059990667495767",3050]
["MYOGENESIS","0.046846920532862","0.075559549246551",3016]
["HEDGEHOG_SIGNALING","0.042556107779931","0.073372599620571",3026]
["KRAS_SIGNALING_UP","0.016790121863377","0.032288695891109",3116]
["TGF_BETA_SIGNALING","0.045088792891935","0.075147988153225",3020]
["IL2_STAT5_SIGNALING","0.011721469092043","0.025481454547921",3148]
["COAGULATION","0.052963938600841","0.080248391819456",3003]
["APICAL_JUNCTION","0.014535960890177","0.029071921780353",3129]
["WNT_BETA_CATENIN_SIGNALING","0.095148037902888","0.135925768432698",2937]
["APOPTOSIS","0.195835947245622","0.264643171953543",2844]
["HYPOXIA","0.323751507639791","0.367899440499763",2768]
["MITOTIC_SPINDLE","0.283930343214642","0.351135287265329",2789]
["NOTCH_SIGNALING","0.65270825473049","0.679904432010927",2635]
["PROTEIN_SECRETION","0.95333397521462","0.95333397521462",2508]
["ANDROGEN_RESPONSE","0.772912777554","0.788686507708164",2451]
["UV_RESPONSE_UP","0.24102469242971","0.317137753196987",2232]
["PI3K_AKT_MTOR_SIGNALING","0.293096780951022","0.351135287265329",2262]
["APICAL_SURFACE","0.294953641302876","0.351135287265329",2263]
["P53_PATHWAY","0.193060590469199","0.264643171953543",2200]
["UNFOLDED_PROTEIN_RESPONSE","0.354321568859393","0.385132140064557",2293]
["DNA_REPAIR","0.262729656686243","0.336832893187491",2245]
["G2M_CHECKPOINT","0.367044111479114","0.390472459020334",2299]
["MYC_TARGETS_V2","0.335767104945452","0.373074561050502",2284]
["E2F_TARGETS","0.315898711915881","0.367324083623118",2274]
["SPERMATOGENESIS","0.051014422058991","0.079710034467174",2039]
["KRAS_SIGNALING_DN","0.021999635351123","0.040740065465042",1955]
["GLYCOLYSIS","0.004084719029612","0.009283452340028",1811]
["HEME_METABOLISM","0.000245780848026","0.000819269493421",1614]
["MYC_TARGETS_V1","0.067813292530396","0.099725430191759",2070]
["ESTROGEN_RESPONSE_EARLY","0.000181620068893","0.00069853872651",1595]
["BILE_ACID_METABOLISM","0.000368484870925","0.001083779032133",1640]
["ESTROGEN_RESPONSE_LATE","1.11756533930665E-05","6.20869632948139E-05",1434]
["ADIPOGENESIS","4.76915386819239E-06","2.98072116762025E-05",1389]
["PEROXISOME","2.96805207231431E-08","4.94675345385718E-07",1149]
["XENOBIOTIC_METABOLISM","6.89193807831192E-09","1.72298451957798E-07",1087]
["MTORC1_SIGNALING","4.67806696176586E-06","2.98072116762025E-05",1388]
["REACTIVE_OXYGEN_SPECIES_PATHWAY","1.58108042427951E-06","1.31756702023293E-05",1333]
["CHOLESTEROL_HOMEOSTASIS","2.93438828779185E-07","3.66798535973981E-06",1252]
["OXIDATIVE_PHOSPHORYLATION","6.82856521368365E-07","6.82856521368365E-06",1292]
["FATTY_ACID_METABOLISM","1.7168681125316E-14","8.584340562658E-13",622]

{"sheet":"Supplementary_Table10","index":9,"n_rows":52,"n_cols":4,"rows_kept":52,"merged":[[0,0,0,8]]}
["MPS1 vs. MPS2 differential testing results on the MSigDB hallmarks GSVA enrichment scores for the TCGA cohort HPV-negative cases (n=241). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["EPITHELIAL_MESENCHYMAL_TRANSITION","9.55279189808984E-12","5.97049493630615E-11",10946]
["ANGIOGENESIS","1.58191699911159E-10","8.78842777284218E-10",10721]
["INFLAMMATORY_RESPONSE","5.73381128902536E-09","2.04778974608049E-08",10411]
["UV_RESPONSE_DN","1.74673508575442E-12","1.26435521242392E-11",11076]
["HEDGEHOG_SIGNALING","2.09800452314385E-07","6.55626413482454E-07",10068]
["KRAS_SIGNALING_UP","4.80380140380212E-10","2.00158391825089E-09",10628]
["IL6_JAK_STAT3_SIGNALING","2.3466974300749E-06","5.33340325017023E-06",9814]
["TGF_BETA_SIGNALING","3.81494682663571E-06","8.29336266659936E-06",9760]
["APICAL_JUNCTION","1.80222461376177E-09","6.93163312985297E-09",10514]
["COAGULATION","3.39869199589414E-07","9.9961529291004E-07",10019]
["IL2_STAT5_SIGNALING","6.01169997240969E-07","1.58202630852887E-06",9960]
["INTERFERON_ALPHA_RESPONSE","0.000163748441654","0.000248103699475",9299]
["COMPLEMENT","1.02204212872762E-06","2.55510532181905E-06",9904]
["TNFA_SIGNALING_VIA_NFKB","0.000155465778112","0.0002429152783",9306]
["INTERFERON_GAMMA_RESPONSE","2.87417085428497E-05","5.1324479540803E-05",9523]
["MYOGENESIS","0.000825296417099","0.001146245023749",9069]
["WNT_BETA_CATENIN_SIGNALING","4.76667486839034E-05","7.9444581139839E-05",9460]
["APICAL_SURFACE","0.000383540843254","0.000564030651845",9181]
["ALLOGRAFT_REJECTION","9.63007670169112E-06","1.900092240138E-05",9654]
["MITOTIC_SPINDLE","0.002342905502062","0.0031660885163",8906]
["HYPOXIA","0.033481699029773","0.041852123787216",8410]
["NOTCH_SIGNALING","0.024561224580682","0.032317400764056",8476]
["APOPTOSIS","0.063391739733292","0.073711325271269",8264]
["ANDROGEN_RESPONSE","0.977147068854542","0.977147068854542",7275]
["KRAS_SIGNALING_DN","0.393711347229926","0.418841858755241",6797]
["PANCREAS_BETA_CELLS","0.674159160871192","0.687917511093053",7031]
["PROTEIN_SECRETION","0.409266910695818","0.426319698641477",6812]
["ESTROGEN_RESPONSE_EARLY","0.111350309167454","0.123722565741615",6397]
["G2M_CHECKPOINT","0.388606771783898","0.418841858755241",6792]
["HEME_METABOLISM","0.027663060746202","0.035465462495131",6067]
["SPERMATOGENESIS","0.049573632720549","0.059016229429224",6196]
["PI3K_AKT_MTOR_SIGNALING","0.043097439671581","0.052557853258026",6164]
["UV_RESPONSE_UP","0.000143242430205","0.000231036177751",5201]
["E2F_TARGETS","0.102898008624096","0.116929555254654",6376]
["UNFOLDED_PROTEIN_RESPONSE","0.000736585764752","0.001052265378217",5432]
["P53_PATHWAY","1.61359128057962E-05","2.98813200107336E-05",4925]
["ESTROGEN_RESPONSE_LATE","2.25143475881148E-08","7.5047825293716E-08",4233]
["BILE_ACID_METABOLISM","3.09202650279566E-05","5.33108017723389E-05",5004]
["GLYCOLYSIS","6.64398501825559E-06","1.38416354546991E-05",4821]
["XENOBIOTIC_METABOLISM","1.98956811736406E-10","9.9478405868203E-10",3816]
["CHOLESTEROL_HOMEOSTASIS","9.88047964871758E-06","1.900092240138E-05",4867]
["DNA_REPAIR","4.50484650708327E-07","1.25134625196758E-06",4528]
["PEROXISOME","6.84218334038821E-19","8.55272917548527E-18",2455]
["REACTIVE_OXYGEN_SPECIES_PATHWAY","1.77009729739349E-12","1.26435521242392E-11",3443]
["ADIPOGENESIS","3.07478995084907E-22","5.12464991808178E-21",2011]
["MTORC1_SIGNALING","8.03653472897536E-13","8.03653472897536E-12",3384]
["FATTY_ACID_METABOLISM","1.17005165373146E-32","5.85025826865731E-31",819]
["MYC_TARGETS_V2","2.22203990355463E-06","5.2905711989396E-06",4698]
["MYC_TARGETS_V1","2.68522415338091E-10","1.22055643335496E-09",3841]
["OXIDATIVE_PHOSPHORYLATION","1.61208189987315E-25","4.03020474968289E-24",1609]

{"sheet":"Supplementary_Table11","index":10,"n_rows":52,"n_cols":4,"rows_kept":52}
["MPS1 vs. MPS2 differential testing results on the MSigDB hallmarks GSVA enrichment scores for the GSE41613 cohort HPV-negative cases (n=96). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["HALLMARK_FATTY_ACID_METABOLISM","3.09327357424047e-14","1.54663678712023e-12",114]
["HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION","2.64558907816683e-10","6.61397269541706e-09",2012]
["HALLMARK_PEROXISOME","1.61728348432937e-09","2.69547247388228e-08",327]
["HALLMARK_OXIDATIVE_PHOSPHORYLATION","3.17655077778696e-09","3.9706884722337e-08",342]
["HALLMARK_APICAL_JUNCTION","7.67139186769271e-09","7.67139186769271e-08",1938]
["HALLMARK_ANGIOGENESIS","1.23480351582916e-08","9.61081442575259e-08",1927]
["HALLMARK_BILE_ACID_METABOLISM","1.34551401960536e-08","9.61081442575259e-08",375]
["HALLMARK_XENOBIOTIC_METABOLISM","1.81421255623572e-08","1.13388284764732e-07",382]
["HALLMARK_HYPOXIA","3.70919635654406e-08","2.06066464252448e-07",1901]
["HALLMARK_TGF_BETA_SIGNALING","1.48177217899345e-07","7.40886089496726e-07",1867]
["HALLMARK_HEDGEHOG_SIGNALING","1.73709356376769e-07","7.89587983530768e-07",1863]
["HALLMARK_ESTROGEN_RESPONSE_LATE","3.12970302004679e-07","1.3040429250195e-06",452]
["HALLMARK_ADIPOGENESIS","5.16386139758653e-07","1.98610053753328e-06",465]
["HALLMARK_WNT_BETA_CATENIN_SIGNALING","1.36918767461156e-06","4.88995598075556e-06",1809]
["HALLMARK_TNFA_SIGNALING_VIA_NFKB","2.83040225509276e-06","9.43467418364255e-06",1789]
["HALLMARK_NOTCH_SIGNALING","7.30027930419419e-06","2.28133728256068e-05",1762]
["HALLMARK_UV_RESPONSE_DN","1.93680367512994e-05","5.69648139744101e-05",1733]
["HALLMARK_INFLAMMATORY_RESPONSE","2.43527216193244e-05","6.76464489425678e-05",1726]
["HALLMARK_KRAS_SIGNALING_DN","4.07171131032847e-05","0.000107150297640223",590]
["HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY","9.69822514306272e-05","0.000242455628576568",618]
["HALLMARK_ESTROGEN_RESPONSE_EARLY","0.000175891693401611","0.000418789746194311",638]
["HALLMARK_COAGULATION","0.000248955104567791","0.000565807055835889",1650]
["HALLMARK_KRAS_SIGNALING_UP","0.000425105987170761","0.000924143450371219",1631]
["HALLMARK_HEME_METABOLISM","0.000792776758305128","0.00165161824646902",692]
["HALLMARK_IL2_STAT5_SIGNALING","0.00126726077375315","0.0025345215475063",1590]
["HALLMARK_COMPLEMENT","0.00438212523370259","0.00842716391096652",1539]
["HALLMARK_APOPTOSIS","0.00588867772120192","0.0109049587429665",1526]
["HALLMARK_CHOLESTEROL_HOMEOSTASIS","0.0064383218400101","0.0114970032857323",778]
["HALLMARK_IL6_JAK_STAT3_SIGNALING","0.0110463036149166","0.0190453510602011",1497]
["HALLMARK_MYOGENESIS","0.0280538403396639","0.0467564005661064",1450]
["HALLMARK_MITOTIC_SPINDLE","0.042575489703147","0.0686701446824951",1427]
["HALLMARK_ALLOGRAFT_REJECTION","0.0609529352439043","0.0923529321877337",1406]
["HALLMARK_GLYCOLYSIS","0.0609529352439043","0.0923529321877337",1406]
["HALLMARK_UV_RESPONSE_UP","0.0966831758567597","0.142181140965823",1377]
["HALLMARK_INTERFERON_GAMMA_RESPONSE","0.107438741159387","0.153483915941981",1370]
["HALLMARK_DNA_REPAIR","0.126230047978838","0.175319511081719",1359]
["HALLMARK_INTERFERON_ALPHA_RESPONSE","0.143431052041775","0.193825746002399",1350]
["HALLMARK_UNFOLDED_PROTEIN_RESPONSE","0.200621534519546","0.263975703315193",1325]
["HALLMARK_SPERMATOGENESIS","0.22204406749153","0.284671881399398",983]
["HALLMARK_P53_PATHWAY","0.239152874784515","0.298941093480644",989]
["HALLMARK_PANCREAS_BETA_CELLS","0.257171075903995","0.313623263297555",1305]
["HALLMARK_MTORC1_SIGNALING","0.272889403842704","0.324868337907981",1000]
["HALLMARK_PROTEIN_SECRETION","0.439086406300685","0.510565588721727",1256]
["HALLMARK_APICAL_SURFACE","0.511571359067103","0.581331089848981",1060]
["HALLMARK_ANDROGEN_RESPONSE","0.772051146572876","0.857834607303195",1110]
["HALLMARK_G2M_CHECKPOINT","0.794588439779949","0.863683086717336",1186]
["HALLMARK_PI3K_AKT_MTOR_SIGNALING","0.817298515624458","0.869466505983466",1118]
["HALLMARK_E2F_TARGETS","0.915310229087877","0.953448155299872",1165]
["HALLMARK_MYC_TARGETS_V1","0.956134487236928","0.967824461053058",1142]
["HALLMARK_MYC_TARGETS_V2","0.967824461053058","0.967824461053058",1156]

{"sheet":"Supplementary_Table12","index":11,"n_rows":52,"n_cols":4,"rows_kept":52}
["MPS1 vs. MPS2 differential testing results on the MSigDB hallmarks GSVA enrichment scores for the GSE65858 cohort HPV-negative cases (n=176). Wilcoxon test and Benjamini-Hochberg P-value adjustement method were applied. Statistic: Wilcoxon test statistic."]
["pathway","p.value","adj.p.value","statistic"]
["HALLMARK_FATTY_ACID_METABOLISM","1.25893020604963e-21","6.29465103024816e-20",601]
["HALLMARK_PEROXISOME","6.97497281718511e-15","1.74374320429628e-13",1193]
["HALLMARK_OXIDATIVE_PHOSPHORYLATION","1.04184686702462e-13","1.73641144504103e-12",1310]
["HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION","9.34679843418047e-13","1.16834980427256e-11",6191]
["HALLMARK_ADIPOGENESIS","1.05121332431144e-11","1.05121332431144e-10",1523]
["HALLMARK_XENOBIOTIC_METABOLISM","1.37532948084982e-11","1.14610790070819e-10",1536]
["HALLMARK_ANGIOGENESIS","4.217960124597e-11","3.01282866042643e-10",6009]
["HALLMARK_COAGULATION","2.39849583073243e-10","1.49905989420777e-09",5921]
["HALLMARK_ESTROGEN_RESPONSE_LATE","3.80809916273763e-10","2.11561064596535e-09",1703]
["HALLMARK_KRAS_SIGNALING_DN","9.10790217651279e-10","4.5539510882564e-09",1749]
["HALLMARK_BILE_ACID_METABOLISM","2.52181464158163e-09","1.14627938253711e-08",1804]
["HALLMARK_INFLAMMATORY_RESPONSE","1.23939470190996e-08","5.16414459129149e-08",5707]
["HALLMARK_APICAL_JUNCTION","1.78653785770808e-08","6.87129945272339e-08",5686]
["HALLMARK_IL2_STAT5_SIGNALING","3.37102574160363e-08","1.20393776485844e-07",5649]
["HALLMARK_ESTROGEN_RESPONSE_EARLY","4.49498893699961e-08","1.49832964566654e-07",1968]
["HALLMARK_COMPLEMENT","1.97787544127377e-07","6.18086075398055e-07",5542]
["HALLMARK_KRAS_SIGNALING_UP","2.81100582753213e-07","8.2676641986239e-07",5520]
["HALLMARK_IL6_JAK_STAT3_SIGNALING","6.24852949024097e-07","1.73570263617805e-06",5469]
["HALLMARK_MYOGENESIS","7.28882115461252e-07","1.91811083016119e-06",5459]
["HALLMARK_ALLOGRAFT_REJECTION","7.00462215897572e-06","1.75115553974393e-05",5305]
["HALLMARK_TNFA_SIGNALING_VIA_NFKB","1.66696712138912e-05","3.96896933664076e-05",5242]
["HALLMARK_HYPOXIA","2.36062621350843e-05","5.36505957615552e-05",5216]
["HALLMARK_WNT_BETA_CATENIN_SIGNALING","3.45624824662966e-05","7.51358314484708e-05",5187]
["HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY","4.25230940794778e-05","8.85897793322453e-05",2429]
["HALLMARK_INTERFERON_GAMMA_RESPONSE","0.000111844325442204","0.000223688650884409",5094]
["HALLMARK_APOPTOSIS","0.000183369829574411","0.000352634287643098",5053]
["HALLMARK_CHOLESTEROL_HOMEOSTASIS","0.000313960812018348","0.000581408911145089",2593]
["HALLMARK_MTORC1_SIGNALING","0.000726192439048294","0.00129677221258624",2668]
["HALLMARK_MYC_TARGETS_V1","0.000791928322984312","0.00136539366031778",2676]
["HALLMARK_SPERMATOGENESIS","0.00309276238591958","0.00515460397653264",2809]
["HALLMARK_UV_RESPONSE_DN","0.00999327492973856","0.0161181853705461",4663]
["HALLMARK_ANDROGEN_RESPONSE","0.0108904479390506","0.0170163249047666",2947]
["HALLMARK_HEME_METABOLISM","0.0117583783560037","0.0178157247818237",2956]
["HALLMARK_INTERFERON_ALPHA_RESPONSE","0.0161363090869627","0.0237298663043569",4606]
["HALLMARK_MITOTIC_SPINDLE","0.0205464959056294","0.029352137008042",4576]
["HALLMARK_NOTCH_SIGNALING","0.0471792277233603","0.0655267051713338",4465]
["HALLMARK_TGF_BETA_SIGNALING","0.0531238070519157","0.0717889284485347",4448]
["HALLMARK_MYC_TARGETS_V2","0.0798216041407491","0.105028426500986",3213]
["HALLMARK_PANCREAS_BETA_CELLS","0.107756650541257","0.13814955197597",4339]
["HALLMARK_HEDGEHOG_SIGNALING","0.137304943579182","0.171631179473977",4298]
["HALLMARK_E2F_TARGETS","0.16352501322698","0.194672634794024",3333]
["HALLMARK_G2M_CHECKPOINT","0.160833529451059","0.194672634794024",3330]
["HALLMARK_APICAL_SURFACE","0.190302483421495","0.221281957466855",4239]
["HALLMARK_PROTEIN_SECRETION","0.317763682583464","0.361095093844845",3465]
["HALLMARK_P53_PATHWAY","0.385587322914966","0.428430358794407",3509]
["HALLMARK_GLYCOLYSIS","0.436542268197548","0.470045491347488",3539]
["HALLMARK_PI3K_AKT_MTOR_SIGNALING","0.441842761866639","0.470045491347488",4058]
["HALLMARK_UNFOLDED_PROTEIN_RESPONSE","0.463409446131076","0.482718173053205",4046]
["HALLMARK_UV_RESPONSE_UP","0.856604882607606","0.874086614905721",3861]
["HALLMARK_DNA_REPAIR","0.946421199251897","0.946421199251897",3777]

{"sheet":"Supplementary_Table13","index":12,"n_rows":92,"n_cols":6,"rows_kept":92}
["MPS1 and MPS2 MSigDB hallmarks enrichment results (enrichR) of malignant cell slusters (n=1313 cells) of the Puram et al. HPV-negative HNSCC data set."]
["pathway","p.value","adj.p.value","num_genes","odds_ratio","class"]
["HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION","6.65052401368759e-31","2.99273580615941e-29",38,"17.4923192913015","MPS1"]
["HALLMARK_INTERFERON_ALPHA_RESPONSE","5.12878603350348e-15","5.76988428769141e-14",18,"15.8532184217614","MPS1"]
["HALLMARK_TGF_BETA_SIGNALING","1.33451692169209e-06","4.28951867686745e-06",8,"11.7057772483621","MPS1"]
["HALLMARK_INTERFERON_GAMMA_RESPONSE","2.92161192769266e-19","6.5736268373085e-18",28,"11.687414500684","MPS1"]
["HALLMARK_ANDROGEN_RESPONSE","3.32335652397261e-09","1.86938804473459e-08",13,"10.2114221634827","MPS1"]
["HALLMARK_TNFA_SIGNALING_VIA_NFKB","3.99947013315321e-16","5.99920519972981e-15",25,"10.1428571428571","MPS1"]
["HALLMARK_APOPTOSIS","3.96772554667692e-11","3.57095299200923e-10",18,"8.72950453801518","MPS1"]
["HALLMARK_COAGULATION","2.56754507875155e-09","1.65056469348314e-08",15,"8.37697903294822","MPS1"]
["HALLMARK_ANGIOGENESIS","0.00200251495461723","0.00391796404164241",4,"8.30574324324324","MPS1"]
["HALLMARK_HYPOXIA","1.94698605544135e-10","1.46023954158101e-09",19,"7.29165765517784","MPS1"]
["HALLMARK_APICAL_SURFACE","0.00420233685526652","0.00756420633947973",4,"6.64189189189189","MPS1"]
["HALLMARK_APICAL_JUNCTION","9.73118266401024e-09","4.37903219880461e-08",17,"6.40655351522524","MPS1"]
["HALLMARK_INFLAMMATORY_RESPONSE","9.73118266401024e-09","4.37903219880461e-08",17,"6.40655351522524","MPS1"]
["HALLMARK_IL6_JAK_STAT3_SIGNALING","0.000334074393018841","0.000715873699326088",7,"5.85921501706485","MPS1"]
["HALLMARK_ESTROGEN_RESPONSE_EARLY","3.75051916185507e-07","1.29825663294983e-06",15,"5.55192034139403","MPS1"]
["HALLMARK_ESTROGEN_RESPONSE_LATE","3.75051916185507e-07","1.29825663294983e-06",15,"5.55192034139403","MPS1"]
["HALLMARK_ALLOGRAFT_REJECTION","3.75051916185507e-07","1.29825663294983e-06",15,"5.55192034139403","MPS1"]
["HALLMARK_COMPLEMENT","2.09496840148449e-06","6.28490520445348e-06",14,"5.13564929693962","MPS1"]
["HALLMARK_UV_RESPONSE_DN","6.49278690371216e-05","0.000162319672592804",10,"5.0349974266598","MPS1"]
["HALLMARK_CHOLESTEROL_HOMEOSTASIS","0.00508999188654683","0.00880960134210028",5,"4.82215671825104","MPS1"]
["HALLMARK_UV_RESPONSE_UP","0.000140659784551449","0.000333141594990273",10,"4.55545200372787","MPS1"]
["HALLMARK_IL2_STAT5_SIGNALING","4.94085183190633e-05","0.000137302151852541",12,"4.34781639928699","MPS1"]
["HALLMARK_KRAS_SIGNALING_UP","5.186970181096e-05","0.000137302151852541",12,"4.32446808510638","MPS1"]
["HALLMARK_P53_PATHWAY","0.00022771049843224","0.000512348621472541",11,"3.92927628567767","MPS1"]
["HALLMARK_HEDGEHOG_SIGNALING","0.101323984907712","0.147083203898292",2,"3.88195815238847","MPS1"]
["HALLMARK_FATTY_ACID_METABOLISM","0.00270157170800054","0.005065446952501",8,"3.57077625570776","MPS1"]
["HALLMARK_GLYCOLYSIS","0.000912638219893532","0.00186675999523677",10,"3.54083484573503","MPS1"]
["HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY","0.167218007157619","0.23476574190122",2,"2.80636869912894","MPS1"]
["HALLMARK_PEROXISOME","0.0714455213482261","0.107168282022339",4,"2.64864864864865","MPS1"]
["HALLMARK_MYOGENESIS","0.0316269837579858","0.0490763541072193",7,"2.41470229358609","MPS1"]
["HALLMARK_MTORC1_SIGNALING","0.0316269837579858","0.0490763541072193",7,"2.41470229358609","MPS1"]
["HALLMARK_XENOBIOTIC_METABOLISM","0.0316269837579858","0.0490763541072193",7,"2.41470229358609","MPS1"]
["HALLMARK_PROTEIN_SECRETION","0.174857512644924","0.23476574190122",3,"2.12957532312371","MPS1"]
["HALLMARK_NOTCH_SIGNALING","0.383695140110287","0.442725161665716",1,"2.12201963534362","MPS1"]
["HALLMARK_G2M_CHECKPOINT","0.209067126934741","0.261333908668427",3,"1.94078035254506","MPS1"]
["HALLMARK_HEME_METABOLISM","0.182595577034283","0.23476574190122",5,"1.69534984789222","MPS1"]
["HALLMARK_KRAS_SIGNALING_DN","0.182595577034283","0.23476574190122",5,"1.69534984789222","MPS1"]
["HALLMARK_MITOTIC_SPINDLE","0.349340955028914","0.41772306471768",4,"1.35169785169785","MPS1"]
["HALLMARK_G2M_CHECKPOINT","0.352743921317152","0.41772306471768",4,"1.34473248758963","MPS1"]
["HALLMARK_BILE_ACID_METABOLISM","0.50271544638507","0.565554877183204",2,"1.19524100061013","MPS1"]
["HALLMARK_MYC_TARGETS_V1","0.579620113950195","0.636168417750214",3,1,"MPS1"]
["HALLMARK_ADIPOGENESIS","0.804592980118748","0.838244334799934",2,"0.661039929496305","MPS1"]
["HALLMARK_OXIDATIVE_PHOSPHORYLATION","0.804592980118748","0.838244334799934",2,"0.661039929496305","MPS1"]
["HALLMARK_UNFOLDED_PROTEIN_RESPONSE","0.819616682915491","0.838244334799934",1,"0.584925943621596","MPS1"]
["HALLMARK_SPERMATOGENESIS","0.870910481510389","0.870910481510389",1,"0.488344232017172","MPS1"]
["HALLMARK_CHOLESTEROL_HOMEOSTASIS","3.02440411047588e-17","6.80490924857074e-16",18,"22.3905775075988","MPS2"]
["HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY","2.4330461074e-09","2.18974149666e-08",10,"17.3837312113174","MPS2"]
["HALLMARK_MTORC1_SIGNALING","2.40409977622169e-20","1.08184489929976e-18",29,"12.2211648432274","MPS2"]
["HALLMARK_FATTY_ACID_METABOLISM","2.1363387933867e-09","2.18974149666e-08",16,"7.75957151358857","MPS2"]
["HALLMARK_XENOBIOTIC_METABOLISM","1.94698605544135e-10","2.92047908316202e-09",19,"7.29165765517784","MPS2"]
["HALLMARK_ANDROGEN_RESPONSE","1.96497278712072e-05","0.000126319679172046",9,"6.66443865412938","MPS2"]
["HALLMARK_PEROXISOME","2.69363547584842e-05","0.000151516995516473",9,"6.38252848616386","MPS2"]
["HALLMARK_BILE_ACID_METABOLISM","4.85284547502735e-05","0.000242642273751367",9,"5.88439595636072","MPS2"]
["HALLMARK_ESTROGEN_RESPONSE_LATE","2.09496840148449e-06","1.57122630111337e-05",14,"5.13564929693962","MPS2"]
["HALLMARK_NOTCH_SIGNALING","0.0828909799972081","0.149203763994975",2,"4.40044742729306","MPS2"]
["HALLMARK_APOPTOSIS","0.000745025969808613","0.00304783351285342",9,"3.97748236570808","MPS2"]
["HALLMARK_GLYCOLYSIS","0.00022771049843224","0.00102469724294508",11,"3.92927628567767","MPS2"]
["HALLMARK_TGF_BETA_SIGNALING","0.0473192189992339","0.11207183447187",3,"3.89166171519113","MPS2"]
["HALLMARK_ANGIOGENESIS","0.101323984907712","0.175368435417194",2,"3.88195815238847","MPS2"]
["HALLMARK_UV_RESPONSE_UP","0.00270157170800054","0.00935159437384801",8,"3.57077625570776","MPS2"]
["HALLMARK_ADIPOGENESIS","0.000912638219893532","0.00342239332460075",10,"3.54083484573503","MPS2"]
["HALLMARK_WNT_BETA_CATENIN_SIGNALING","0.13078686867808","0.217978114463467",2,"3.29865771812081","MPS2"]
["HALLMARK_ESTROGEN_RESPONSE_EARLY","0.00331688542578049","0.00995065627734146",9,"3.15901117288282","MPS2"]
["HALLMARK_P53_PATHWAY","0.00331688542578049","0.00995065627734146",9,"3.15901117288282","MPS2"]
["HALLMARK_UV_RESPONSE_DN","0.0216407011266025","0.0608644719185694",6,"2.89293108547767","MPS2"]
["HALLMARK_G2M_CHECKPOINT","0.0734420374339277","0.149203763994975",4,"2.62229060743912","MPS2"]
["HALLMARK_MYOGENESIS","0.0316269837579858","0.0790674593949644",7,"2.41470229358609","MPS2"]
["HALLMARK_MYC_TARGETS_V1","0.0316269837579858","0.0790674593949644",7,"2.41470229358609","MPS2"]
["HALLMARK_IL6_JAK_STAT3_SIGNALING","0.142458339250077","0.225692322729274",3,"2.35882635882636","MPS2"]
["HALLMARK_MYC_TARGETS_V2","0.21611498518506","0.28603453921552",2,"2.3542665388303","MPS2"]
["HALLMARK_APICAL_JUNCTION","0.0813772595593867","0.149203763994975",6,"2.05196717862403","MPS2"]
["HALLMARK_E2F_TARGETS","0.0813772595593867","0.149203763994975",6,"2.05196717862403","MPS2"]
["HALLMARK_OXIDATIVE_PHOSPHORYLATION","0.0813772595593867","0.149203763994975",6,"2.05196717862403","MPS2"]
["HALLMARK_HEME_METABOLISM","0.0813772595593867","0.149203763994975",6,"2.05196717862403","MPS2"]
["HALLMARK_SPERMATOGENESIS","0.145446163536643","0.225692322729274",4,"2.01867134309882","MPS2"]
["HALLMARK_COAGULATION","0.153790660673551","0.230685991010327",4,"1.97317466720452","MPS2"]
["HALLMARK_IL2_STAT5_SIGNALING","0.18006511862621","0.248993968683113",5,"1.70417613139962","MPS2"]
["HALLMARK_TNFA_SIGNALING_VIA_NFKB","0.182595577034283","0.248993968683113",5,"1.69534984789222","MPS2"]
["HALLMARK_HYPOXIA","0.182595577034283","0.248993968683113",5,"1.69534984789222","MPS2"]
["HALLMARK_APICAL_SURFACE","0.48609667500118","0.546858759376328",1,"1.52889476549739","MPS2"]
["HALLMARK_PROTEIN_SECRETION","0.423380409419285","0.488515857022252",2,"1.39982864486649","MPS2"]
["HALLMARK_G2M_CHECKPOINT","0.352743921317152","0.41772306471768",4,"1.34473248758963","MPS2"]
["HALLMARK_COMPLEMENT","0.352743921317152","0.41772306471768",4,"1.34473248758963","MPS2"]
["HALLMARK_INFLAMMATORY_RESPONSE","0.352743921317152","0.41772306471768",4,"1.34473248758963","MPS2"]
["HALLMARK_KRAS_SIGNALING_UP","0.352743921317152","0.41772306471768",4,"1.34473248758963","MPS2"]
["HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION","0.579620113950195","0.621021550660923",3,1,"MPS2"]
["HALLMARK_KRAS_SIGNALING_DN","0.579620113950195","0.621021550660923",3,1,"MPS2"]
["HALLMARK_INTERFERON_GAMMA_RESPONSE","0.804592980118748","0.822879184212356",2,"0.661039929496305","MPS2"]
["HALLMARK_ALLOGRAFT_REJECTION","0.804592980118748","0.822879184212356",2,"0.661039929496305","MPS2"]
["HALLMARK_MITOTIC_SPINDLE","0.951329367249311","0.951329367249311",1,"0.329414546805851","MPS2"]

{"sheet":"Supplementary_Table14","index":13,"n_rows":58,"n_cols":7,"rows_kept":58,"merged":[[0,0,0,10]]}
["PROGENy differential analysis results comparing MPS1 vs. MPS2, for the LMU-KKG 13-16 (n=145), TCGA (n=241), GSE41613 (n=96), and GSE65858 (n=176) HPV-negative cases."]
["estimate","std.error","statistic","p.value","pathway","logpval","dataset"]
["-0.0264977631260615","0.129099191633036","-0.205251193217239","0.837550579449971","Androgen","0.255751777840624","TCGA"]
["-0.00364436169253292","0.129110353954302","-0.0282267190888721","0.977504882167532","EGFR","0.0328241868803664","TCGA"]
["0.0397098284900491","0.129085015723631","0.307625391432474","0.758635300303263","Estrogen","0.398521591186168","TCGA"]
["-0.177157962998799","0.128601015983891","-1.37757825351077","0.169622144413276","Hypoxia","2.55960356679214","TCGA"]
["0.50220867150965","0.124957001603776","4.0190518743567","7.83431878943929e-05","JAK-STAT","13.6398326396654","TCGA"]
["0.129029124796424","0.128840521615023","1.00146384987454","0.317615457166496","MAPK","1.65464697008025","TCGA"]
["0.443415505803355","0.125884361604093","3.52240341971865","0.000512169187282994","NFkB","10.9310919182798","TCGA"]
["-0.72473151652652","0.120299209720592","-6.02440795920264","6.36869193495679e-09","p53","27.2263557660788","TCGA"]
["-0.0743607475328346","0.129020940155531","-0.576346346904577","0.564923468019177","PI3K","0.823872660612314","TCGA"]
["0.774850297680483","0.118985018107352","6.5121669097986","4.32902683399785e-10","TGFb","31.1052382055755","TCGA"]
["0.482068664617197","0.125288447777917","3.84767050088847","0.000153053040762241","TNFa","12.6736806718356","TCGA"]
["0.612061132360803","0.122890586565904","4.9805371547524","1.21569681106982e-06","Trail","19.6497850968793","TCGA"]
["-0.257689851107071","0.128030066063533","-2.01272918955768","0.0452648242212271","VEGF","4.46546583784461","TCGA"]
["0.505230498955906","0.124906022922071","4.0448850034327","7.06818907069219e-05","WNT","13.7882998426257","TCGA"]
["-0.27384378699389","0.167961970858618","-1.63039160349219","0.105219410380287","Androgen","3.24852722413293","LMU-KKG"]
["0.0901392663089433","0.169348201618398","0.532271765790931","0.595363826768136","EGFR","0.748156526196168","LMU-KKG"]
["-0.387817109777221","0.166384702339091","-2.33084595113109","0.0211592360854854","Estrogen","5.56256864717988","LMU-KKG"]
["-0.137976647999015","0.169122743668363","-0.815837332142491","0.415950033294524","Hypoxia","1.26551786230897","LMU-KKG"]
["0.393144525691459","0.166297248067456","2.36410722522591","0.0194180155431927","JAK-STAT","5.68646042013413","LMU-KKG"]
["0.16612363826196","0.168945688693255","0.983296108630396","0.327122453395284","MAPK","1.61209730675901","LMU-KKG"]
["0.455515719481499","0.165180571496858","2.75768339674356","0.00658158526783633","NFkB","7.24734916535374","LMU-KKG"]
["-0.725338858608422","0.158292438547579","-4.58227105011338","9.93393871167578e-06","p53","16.6192027233578","LMU-KKG"]
["-0.157388477375851","0.16900416408757","-0.931269819448356","0.353283570563369","PI3K","1.50110143656706","LMU-KKG"]
["0.61538340222598","0.161515953672245","3.81004717016836","0.000205716738425237","TGFb","12.2470531940453","LMU-KKG"]
["0.532246541073354","0.163568360461783","3.25397001945073","0.00142032687386798","TNFa","9.45956129504512","LMU-KKG"]
["0.0652843576426153","0.16942794237364","0.385322259882279","0.700571226172912","Trail","0.513396359830631","LMU-KKG"]
["0.165352414169802","0.16895097938915","0.978700536496688","0.329380800247279","VEGF","1.60217163270508","LMU-KKG"]
["0.284413559245556","0.167839090640309","1.69456089258177","0.0923354336580104","WNT","3.43697180243659","LMU-KKG"]
["-0.714276350392724","0.142684461659105","-5.00598552979961","1.35370187537235e-06","Androgen","19.4946585189482","GSE65858"]
["0.53665876879592","0.147091123231345","3.64847828343701","0.000348439245889884","EGFR","11.4868052508424","GSE65858"]
["-0.449618728597482","0.148758745089053","-3.02246922241998","0.00288604314999518","Estrogen","8.43669141455623","GSE65858"]
["0.209044497692036","0.151788797175172","1.37720636557116","0.170217550596907","Hypoxia","2.55454829844083","GSE65858"]
["0.329505636301072","0.15055563020033","2.18859723719818","0.0299582684511006","JAK-STAT","5.06090194946278","GSE65858"]
["0.531442043227263","0.147199937016592","3.6103415123565","0.00039970164083064","MAPK","11.2887888843158","GSE65858"]
["0.790731901024873","0.140347979680085","5.63408110916383","6.962928220475e-08","NFkB","23.7757306080921","GSE65858"]
["-1.07257982794375","0.12914849538409","-8.30501218580887","2.70809217833815e-14","p53","45.0697164820626","GSE65858"]
["-0.297558976128294","0.150937496287292","-1.97140527335849","0.0502630399926781","PI3K","4.31435825930967","GSE65858"]
["1.00887894367079","0.132065702386827","7.63921991431002","1.39997793632871e-12","TGFb","39.3777330481924","GSE65858"]
["0.869675992567035","0.137638023659511","6.31857367204312","2.14056812061918e-09","TNFa","28.799359105947","GSE65858"]
["0.172108325309721","0.152055084984282","1.13188141868134","0.259241767607814","Trail","1.94762991884773","GSE65858"]
["0.679668899420886","0.143652713528375","4.7313335246301","4.59661735372985e-06","VEGF","17.7309959955891","GSE65858"]
["0.506147996187059","0.147711387293686","3.42660105940725","0.000762660777393925","WNT","10.3566708737268","GSE65858"]
["-0.6546088210824","0.193970404703131","-3.37478710777693","0.00107492253790072","Androgen","9.86155158597578","GSE41613"]
["0.78688912415269","0.188668991284425","4.1707390217952","6.76085153047434e-05","EGFR","13.8524355087837","GSE41613"]
["-0.46227974119589","0.19977420318269","-2.31401118778656","0.0228457940737851","Estrogen","5.45192760118318","GSE41613"]
["0.658303402724043","0.193837341912889","3.39616400136093","0.00100290766056221","Hypoxia","9.96159550401766","GSE41613"]
["0.231032492038698","0.203998367195352","1.13252128051328","0.260295929853201","JAK-STAT","1.94177534183343","GSE41613"]
["0.769330385792539","0.189437806242707","4.06112381182706","0.000101100666897905","MAPK","13.2719198657197","GSE41613"]
["0.878271504361591","0.184329046554033","4.76469401204297","6.86949732890705e-06","NFkB","17.1513640347095","GSE41613"]
["-1.12954941978966","0.169144766761934","-6.67800394545734","1.68322932992276e-09","p53","29.1461211053618","GSE41613"]
["0.34673512923737","0.202247797806623","1.71440743977295","0.0897493417399351","PI3K","3.47795483214281","GSE41613"]
["1.07516676228641","0.172874134036658","6.21936166609183","1.36954310208011e-08","TGFb","26.1217300880328","GSE41613"]
["0.979367231205284","0.178827660342792","5.47659813547831","3.60194696712915e-07","TNFa","21.4047197241731","GSE41613"]
["0.230303044806519","0.204007141584871","1.12889697398514","0.261814112836945","Trail","1.93338522842504","GSE41613"]
["-0.0348302021968539","0.205353982091518","-0.169610551702531","0.865680907621087","VEGF","0.20809275333711","GSE41613"]
["-0.109892271562165","0.205072407553892","-0.535870587725394","0.593313727626862","WNT","0.753132931758964","GSE41613"]

{"sheet":"Supplementary_Table15","index":14,"n_rows":8,"n_cols":4,"rows_kept":8}
["Univariable Cox PH analysis results with CSPG-positive tumor cell %, quantified by QuPath on the LMU-KKG HPV-negative cohort IHC images (n=115)."]
["Endpoint","P-value","Adj. P-value","HR (95% CI)"]
["OS","0.089","0.107","1.014 (0.998-1.031)"]
["RFS","0.064","0.096","1.015 (0.999-1.031)"]
["LR-RFS","0.058","0.096","1.015 (0.999-1.031)"]
["DSS","0.038","0.096","1.030 (1.002-1.059)"]
["FFR","0.054","0.096","1.024 (1.000-1.049)"]
["LRC","0.254","0.254","1.019 (0.989-1.051)"]

{"sheet":"Supplementary_table16","index":15,"n_rows":30,"n_cols":22,"rows_kept":30}
["Cell type marker genes recovered from the mouse genome-aligned xenograft gene expression data (SCC-131, Cal33) using SSMD. "]
["neutrophil_1","fibroblast_1","fibroblast_2","fibroblast_3","fibroblast_4","mast_1","mast_2","mast_3","mast_4","HSC_1","HSC_3","monocyte_1","macrophage_1","macrophage_2","macrophage_3","adipocyte_1","endothelial_1","NK_1","dendritic_1","dendritic_2","dendritic_3","B_1"]
["Ccl6","Aebp1","Col12a1","Cdh11","Col16a1","Bod1l","Appl1","Adora3","Adora2b","Ash1l","B230354K17Rik","Acer3","B4galt6","Abhd12","Apobec1","Adamts5","Elk3","Gzma","Arhgap22","5430437J10Rik","Aif1","Cd37"]
["Cybb","B4galt2","Dnm3os","Col1a2","Dclk1","Cadm3","Ggnbp2","Eh","Cd200r1","Atrx","Ccdc173","Apaf1","C1qa","Csf1r","Cmtm3","Arl4a","Lamb1","Osbpl3","Gpr35","Amz1","Ccrl2","Ciita"]
["Fcgr3","Cald1","Ikbip","Col3a1","Fgfr1","Cd55","Med15","Golim4","Cd300lb","Bclaf1","Cd47","Atad2b","C1qb","Ctss","Ctsl","Cd163","Lima1","Polr2b","H2-Ab1","Bcl2a1d","Itgax","H2-DMb1"]
["Fgd4","Cd248","Loxl2","Col8a1","Fkbp10","Cma1","Osbpl8","Hmgb1","Hcfc2","Cbx3","Chek1","Ccr2","C1qc","Fcgr1","Dse1l1","Cd209f","Luzp1","Prss2","H2-DMa","Egr2","Phf11d","Ly86"]
["Gda","Cpt1c","Lrrc15","Csf1","Ncam1","Cpa3","Rock1","Lat2","Hpgds","Chd9","Gpatch4","Clec4a3","C3ar1","Msr1","Evi2a","Clec10a","Nfat5","Rnf157","H2-Eb1","Jak2","Pip4k2a","Pxk"]
["Ggt5","Dnm1","Lrrc17","Cthrc1","Praf2","Crisp1","Taok3","Ogt","Mtss1","Ddx27","Kcnq1ot1","Cyp4f16","Ccl9","Tcirg1","Unc93b1","Dpt","Thoc1","Sec24c","Lacc1","Mpeg1","Rtn1","Snx30"]
["Hdc","Efemp2","Mirg","Fzd2",null,"Csf2rb","Zfr","Specc1","Tax1bp1","Eml4","Mysm1","Dleu2","Cd84",null,null,"Gfpt2","Thrap3","Tspyl3","v1","Mx1","Slamf8","Zfp318"]
["Igsf6","Fstl1","P4ha3","Hoxa1",null,"Dapp1",null,"Trio","Tmeff2","Fam133b","Rnps1","Emilin2","Cfp",null,null,"Htra3","Trip12",null,"Rab43",null,null,"Zfp709"]
["Il17ra","Gpc6","Prrx1","Lrch2",null,"Il3ra",{"$nulls":3},"Luc7l3","Smc1a","F13a1","Clec4n",null,null,"Lrrn4cl","Usp7",null,"Scn2b"]
["Irak3","Meg3","Rcn3","Pdgfrl",null,"Itpr2",{"$nulls":3},"Meis1","Stmn1","Hps3","Ctsb",null,null,"Sik2","Zcrb1"]
["Irak4","Mmp3","Rnd3","Pofut1",null,"Mcpt4",{"$nulls":3},"Mettl14","Xpo7","Map3k5","Ctsz"]
["Itgam","Nfatc4","Sulf1","Rcn2",null,"Plxdc2",{"$nulls":3},"Mllt10",null,"Ms4a6c","Dse"]
["Ltb4r1","Pcolce",null,"Thbs2",null,"Rin3",{"$nulls":3},"Mtf2",null,"Pld4","Fcgr2b"]
["Ncf1","Rpn2",null,"Twist1",null,"Tacc1",{"$nulls":3},"p1l1",null,"Ptpro","Fcrls"]
["Pi16","Shox2",{"$nulls":3},"Tbxas1",{"$nulls":3},"Nop56",null,"Smc6","Folr2"]
["Pirb",{"$nulls":4},"Tnfaip8",{"$nulls":3},"Phf14",null,"Stk38","Kcnk13"]
["Rsel",{"$nulls":4},"Tpsb2",{"$nulls":3},"Prpf6",null,"Tep1","Lipa"]
["Rnf149",{"$nulls":4},"Zeb2",{"$nulls":3},"Rpl5",null,"Vav3","Mrc1"]
["Taf7",{"$nulls":8},"Serbp1",null,null,"Ms4a7"]
["Trim30a",{"$nulls":8},"Ssbp1",null,null,"P2ry6"]
["Xdh",{"$nulls":11},"Pf4"]
[{"$nulls":12},"Pla2g15"]
[{"$nulls":12},"Slc11a1"]
[{"$nulls":12},"Soat1"]
[{"$nulls":12},"Stab1"]
[{"$nulls":12},"Tmem106a"]
[{"$nulls":12},"Trem2"]
[{"$nulls":12},"Wfdc17"]

{"sheet":"Supplementary_Table17","index":16,"n_rows":97,"n_cols":3,"rows_kept":97}
["KEGG metabolic gene sets (n=95). Obtained from the official KEGG website using a custom R script (accessed on 12.10.2021)."]
["pathway","category","gene"]
["Aflatoxin biosynthesis","Biosynthesis of other secondary metabolites","ACACA,ACACB"]
["Alanine, aspartate and glutamate metabolism","Amino acid metabolism","GOT1,GOT1L1,GOT2,IL4I1,DDO,ASRGL1,ASNS,NIT2,GPT2,GPT,AGXT,AGXT2,ASS1,ASL,ADSS1,ADSS2,ADSL,NAT8L,RIMKLB,RIMKLA,FOLH1,ASPA,GAD1,GAD2,ABAT,ALDH5A1,GLUD2,GLUD1,ALDH4A1,GLUL,CAD,GLS2,GLS,CPS1,GFPT2,GFPT1,PPAT"]
["alpha-Linolenic acid metabolism","Lipid metabolism","PLA2G10,PLA2G2D,PLA2G2E,PLA2G3,PLA2G2F,PLA2G12A,PLA2G12B,PLA2G1B,PLA2G5,PLA2G2A,PLA2G2C,PLA2G4E,PLA2G4A,JMJD7-PLA2G4B,PLA2G4B,PLA2G4C,PLA2G4D,PLA2G4F,PLA2G6,PLB1,PLAAT3,FADS2,ACOX3,ACOX1,ACAA1"]
["Amino sugar and nucleotide sugar metabolism","Carbohydrate metabolism","CHIA,CHIT1,HEXA,HEXB,NAGK,PGM3,UAP1,UAP1L1,GALK2,GNE,RENBP,NANS,NANP,NPL,CMAS,CYB5R1,CYB5R3,CYB5R2,CYB5RL,CYB5R4,HK3,HK1,HK2,HKDC1,AMDHD2,GNPNAT1,GNPDA1,GNPDA2,GFPT2,GFPT1,MPI,UXS1,GCK,GPI,PGM1,PGM2,UGP2,UGDH,GALK1,GALT,GALE,PMM2,PMM1,GMPPB,GMPPA,GMDS,GFUS,FCSK,FPGT"]
["Arachidonic acid metabolism","Lipid metabolism","PLA2G10,PLA2G2D,PLA2G2E,PLA2G3,PLA2G2F,PLA2G12A,PLA2G12B,PLA2G1B,PLA2G5,PLA2G2A,PLA2G2C,PLA2G4E,PLA2G4A,JMJD7-PLA2G4B,PLA2G4B,PLA2G4C,PLA2G4D,PLA2G4F,PLA2G6,PLB1,PLAAT3,PTGS1,PTGS2,PTGES,PTGES2,PTGES3,CBR1,CBR3,PRXL2B,TBXAS1,PTGDS,HPGDS,AKR1C3,PTGIS,ALOX5,LTA4H,CYP4F2,CYP4F3,LTC4S,GGT1,GGT5,GPX6,GPX7,GPX2,GPX3,GPX1,GPX5,GPX8,CYP2E1,CYP2J2,CYP2U1,CYP2C19,CYP4F8,ALOX12,ALOX12B,ALOX15B,CYP2B6,CYP2C8,CYP2C9,EPHX2,ALOX15"]
["Arginine and proline metabolism","Amino acid metabolism","GATM,GAMT,CKM,CKMT1A,CKMT2,CKB,CKMT1B,AZIN2,AGMAT,ODC1,SRM,SMS,AMD1,AOC1,SMOX,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,CNDP1,CNDP2,CARNS1,SAT2,SAT1,MAOB,MAOA,NOS1,NOS2,NOS3,ARG2,ARG1,OAT,PYCR3,PYCR2,PYCR1,PRODH,ALDH4A1,ALDH18A1,LAP3,P4HA2,P4HA3,P4HA1,PRODH2,GOT1,GOT1L1,GOT2,HOGA1,DAO,L3HYPDH"]
["Arginine biosynthesis","Amino acid metabolism","OTC,ASS1,ASL,ARG2,ARG1,NOS1,NOS2,NOS3,GLS2,GLS,GLUL,GLUD2,GLUD1,CPS1,GOT1,GOT1L1,GOT2,GPT2,GPT,NAGS,ACY1,ABHD14A-ACY1"]
["Ascorbate and aldarate metabolism","Carbohydrate metabolism","UGDH,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,GUSB,KL,MIOX,AKR1A1,RGN,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1"]
["beta-Alanine metabolism","Metabolism of other amino acids","GADL1,CSAD,GAD1,GAD2,CNDP1,CARNS1,CNDP2,ABAT,SMOX,AOC3,AOC2,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,ALDH3B1,ALDH3B2,ALDH3A1,DPYD,DPYS,UPB1,HIBCH,HADHA,EHHADH,ECHS1,ACADS,ACOX3,ACOX1,MLYCD,ALDH6A1"]
["Biosynthesis of ansamycins","Metabolism of terpenoids and polyketides","TKT,TKTL2,TKTL1"]
["Biosynthesis of unsaturated fatty acids","Lipid metabolism","ELOVL1,ELOVL2,ELOVL3,ELOVL4,ELOVL5,ELOVL6,ELOVL7,HSD17B12,HACD2,HACD1,HACD4,HACD3,TECR,SCD,SCD5,FADS2,FADS1,ACOX3,ACOX1,HSD17B4,ACAA1,SCP2,ACOT4,ACOT2,ACOT1,ACOT7,BAAT"]
["Biosynthesis of vancomycin group antibiotics","Metabolism of terpenoids and polyketides","TGDS"]
["Biotin metabolism","Metabolism of cofactors and vitamins","OXSM,HLCS,BTD"]
["Butanoate metabolism","Carbohydrate metabolism","ACAT2,ACAT1,HADH,HADHA,EHHADH,ECHS1,ACADS,ACSM1,ACSM2A,ACSM4,ACSM5,ACSM3,ACSM2B,ACSM6,L2HGDH,GAD1,GAD2,ABAT,ALDH5A1,HMGCS1,HMGCS2,HMGCL,HMGCLL1,OXCT1,OXCT2,AACS,BDH1,BDH2"]
["C5-Branched dibasic acid metabolism","Carbohydrate metabolism","ACOD1"]
["Caffeine metabolism","Biosynthesis of other secondary metabolites","CYP1A2,NAT2,NAT1,CYP2A6,CYP2A7,XDH"]
["Citrate cycle (TCA cycle)","Carbohydrate metabolism","CS,ACLY,ACO2,ACO1,IDH1,IDH2,IDH3B,IDH3G,IDH3A,OGDHL,OGDH,DLST,DLD,SUCLG1,SUCLG2,SUCLA2,SDHA,SDHB,SDHC,SDHD,FH,MDH1,MDH2,PC,PCK1,PCK2,PDHA2,PDHA1,PDHB,DLAT,PDHX"]
["Cutin, suberine and wax biosynthesis","Lipid metabolism","FAR2,FAR1"]
["Cysteine and methionine metabolism","Amino acid metabolism","CTH,KYAT3,KYAT1,CBS,CBS,BHMT,BHMT2,MTR,MAT2B,MAT1A,MAT2A,AMD1,SRM,SMS,MTAP,MRI1,APIP,ENOPH1,ADI1,TAT,IL4I1,DNMT1,DNMT3A,DNMT3B,AHCYL2,AHCYL1,AHCY,BCAT2,BCAT1,AGXT2,GCLC,GCLM,GSS,CDO1,GOT1,GOT1L1,GOT2,MPST,TST,LDHAL6A,LDHAL6B,LDHA,LDHB,LDHC,MDH1,MDH2,SDS,SDSL,PHGDH,PSAT1"]
["D-Amino acid metabolism","Metabolism of other amino acids","GLS2,GLS,DGLUCY,DDO,SRR,DAO"]
["Drug metabolism - cytochrome P450","Xenobiotics biodegradation and metabolism","CYP2D6,CYP2D7,CYP2D6,CYP2C9,CYP3A4,FMO1,FMO2,FMO5,FMO3,FMO4,CYP2C19,CYP2B6,CYP3A5,GSTA5,GSTA2,GSTA4,GSTO2,GSTM4,GSTT2,GSTT1,GSTM3,MGST1,MGST3,GSTM1,GSTM5,MGST2,GSTA1,GSTM2,GSTA3,GSTO1,GSTT2B,GSTP1,GSTK1,HPGDS,ADH1A,ADH1B,ADH1C,ADH7,ADH4,ADH5,ADH6,ALDH3B1,ALDH3B2,ALDH3A1,MAOB,MAOA,AOX1,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,CYP1A2,CYP2E1,CYP2C8,CYP2A6,CYP2A7"]
["Drug metabolism - other enzymes","Xenobiotics biodegradation and metabolism","HPRT1,IMPDH1,IMPDH2,GMPS,TPMT,XDH,ITPA,CES1,CES2,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,GUSB,CYP3A4,CDA,TYMP,DPYD,DPYS,UPB1,CYP2A6,CYP2A7,UPP2,UPP1,UCK1,UCK2,UCKL1,TK2,TK1,UMPS,CMPK1,RRM1,RRM2B,RRM2,NME6,NME7,NME2,NME4,NME1,NME3,NME1-NME2,DUT,MPO,NAT2,NAT1,CYP2E1,GSTA5,GSTA2,GSTA4,GSTO2,GSTM4,GSTT2,GSTT1,GSTM3,MGST1,MGST3,GSTM1,GSTM5,MGST2,GSTA1,GSTM2,GSTA3,GSTO1,GSTT2B,GSTP1"]
["Ether lipid metabolism","Lipid metabolism","AGPS,PLPP1,PLPP3,PLPP2,SELENOI,CHPT1,CEPT1,PEDS1,PEDS1-UBE2V1,PLA2G10,PLA2G2D,PLA2G2E,PLA2G3,PLA2G2F,PLA2G12A,PLA2G12B,PLA2G1B,PLA2G5,PLA2G2A,PLA2G2C,PLA2G4E,PLA2G4A,JMJD7-PLA2G4B,PLA2G4B,PLA2G4C,PLA2G4D,PLA2G4F,PLA2G6,PLB1,PLAAT3,LPCAT4,ENPP6,ENPP2,GDPD3,GDPD1,TMEM86B,PLD1,PLD2,PLD3,PLD4,UGT8,GAL3ST1,LPCAT2,LPCAT1,PAFAH1B1,PAFAH1B2,PAFAH1B3,PLA2G7,PAFAH2"]
["Fatty acid biosynthesis","Lipid metabolism","ACACA,ACACB,ACSF3,NDUFAB1,MCAT,FASN,OXSM,CBR4,HSD17B8,HTD2,MECR,OLAH,ACSL6,ACSL4,ACSL1,ACSL5,ACSL3,ACSBG1,ACSBG2"]
["Fatty acid degradation","Lipid metabolism","ACAT2,ACAT1,ACAA1,ACAA2,HADHB,HADH,HADHA,EHHADH,ECHS1,ACOX3,ACOX1,ACADS,ACADM,ACADL,ACADSB,ACADVL,GCDH,ACSL6,ACSL4,ACSL1,ACSL5,ACSL3,ACSBG1,ACSBG2,CPT1A,CPT1B,CPT1C,CPT2,ECI1,ECI2,CYP2U1,ADH1A,ADH1B,ADH1C,ADH7,ADH4,ADH5,ADH6,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1"]
["Fatty acid elongation","Lipid metabolism","ACAA2,HADHB,HADH,HADHA,ECHS1,MECR,PPT1,PPT2,ELOVL1,ELOVL2,ELOVL3,ELOVL4,ELOVL5,ELOVL6,ELOVL7,HSD17B12,HACD2,HACD1,HACD4,HACD3,TECR,ACOT4,ACOT2,ACOT1,ACOT7,THEM4,THEM5"]
["Folate biosynthesis","Metabolism of cofactors and vitamins","GCH1,ALPL,ALPI,ALPP,ALPG,DHFR,DHFR2,FPGS,GGH,PTS,SPR,AKR1B1,AKR1B10,CBR1,AKR1C3,QDPR,PCBD2,PCBD1,PAH,TH,TPH2,TPH1,MOCS1,MOCS2,GPHN,MOCOS"]
["Fructose and mannose metabolism","Carbohydrate metabolism","MPI,PMM2,PMM1,GMPPB,GMPPA,GMDS,GFUS,FPGT,FCSK,ENOSF1,HK3,HK1,HK2,HKDC1,PFKM,PFKP,PFKL,FBP1,FBP2,PFKFB1,PFKFB2,PFKFB3,PFKFB4,TIGAR,KHK,SORD,AKR1B1,AKR1B10,ALDOC,ALDOA,ALDOB,TPI1,TKFC"]
["Galactose metabolism","Carbohydrate metabolism","GALM,GALK1,GALT,GALE,UGP2,PGM1,PGM2,HK3,HK1,HK2,HKDC1,GCK,G6PC1,G6PC2,G6PC3,GLB1,LCT,LALBA,B4GALT1,B4GALT2,GLA,AKR1B1,AKR1B10,PFKM,PFKP,PFKL,MGAM,MGAM2,GAA,GANC,SI"]
["Global maps only","Not included in regular maps","PDHX"]
["Glutathione metabolism","Metabolism of other amino acids","GGT7,GGT6,GGT1,GGT5,GGCT,CHAC1,CHAC2,OPLAH,GCLC,GCLM,GSS,LAP3,ANPEP,GSTA5,GSTA2,GSTA4,GSTO2,GSTM4,GSTT2,GSTT1,GSTM3,MGST1,MGST3,GSTM1,GSTM5,MGST2,GSTA1,GSTM2,GSTA3,GSTO1,GSTT2B,GSTP1,GSTK1,HPGDS,LANCL1,NAT8,NAT8B,GSR,IDH1,IDH2,PGD,G6PD,TXNDC12,GPX4,GPX6,GPX7,GPX2,GPX3,GPX1,GPX5,GPX8,PRDX6,ODC1,SRM,SMS,RRM1,RRM2B,RRM2"]
["Glycerolipid metabolism","Lipid metabolism","GLYCTK,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,AKR1B1,AKR1B10,AKR1A1,TKFC,GK2,GK,GPAM,GPAT2,GPAT4,GPAT3,AGPAT1,AGPAT2,AGPAT3,AGPAT4,AGPAT5,LCLAT1,MBOAT1,MBOAT2,PLPP1,PLPP3,PLPP2,LPIN1,LPIN3,LPIN2,PLPP5,PLPP4,DGKZ,DGKD,DGKI,DGKA,DGKE,DGKB,DGKH,DGKG,DGKQ,DGKK,DGAT1,DGAT2,MOGAT3,CEL,PNPLA2,PNPLA3,PNLIP,PNLIPRP1,PNLIPRP2,PNLIPRP3,LIPC,LIPF,LIPG,LPL,AGK,MGLL,MOGAT1,MOGAT2,GLA"]
["Glycerophospholipid metabolism","Lipid metabolism","GPD1L,GPD1,GPD2,GPAM,GPAT2,GPAT4,GPAT3,AGPAT1,AGPAT2,AGPAT3,AGPAT4,AGPAT5,LCLAT1,MBOAT1,MBOAT2,GNPAT,ADPRM,PLPP1,PLPP3,PLPP2,LPIN1,LPIN3,LPIN2,PLPP5,PLPP4,DGKZ,DGKD,DGKI,DGKA,DGKE,DGKB,DGKH,DGKG,DGKQ,DGKK,CHPT1,CEPT1,PLD1,PLD2,PLD3,PLD4,LCAT,PLA2G10,PLA2G2D,PLA2G2E,PLA2G3,PLA2G2F,PLA2G12A,PLA2G12B,PLA2G1B,PLA2G5,PLA2G2A,PLA2G2C,PLA2G4E,PLA2G4A,JMJD7-PLA2G4B,PLA2G4B,PLA2G4C,PLA2G4D,PLA2G4F,PLA2G6,PLB1,PLAAT3,LPCAT2,LPCAT1,LPCAT4,LPCAT3,LYPLA1,PLA2G15,LYPLA2,PNPLA6,PNPLA7,GPCPD1,CHAT,ACHE,CHKA,CHKB,PHOSPHO1,PCYT1B,PCYT1A,SELENOI,ETNK1,ETNK2,PCYT2,ETNPPL,PEMT,CDS1,CDS2,PLA1A,PTDSS1,PTDSS2,PISD,PGS1,CRLS1,TAFAZZIN,LPGAT1,CDIPT,MBOAT7"]
["Glycine, serine and threonine metabolism","Amino acid metabolism","SHMT2,SHMT1,AGXT,GRHPR,GLYCTK,PGAM1,PGAM2,PGAM4,BPGM,PHGDH,PSAT1,PSPH,GCAT,ALAS1,ALAS2,MAOB,MAOA,AOC3,AOC2,GLDC,AMT,DLD,GCSH,DAO,AGXT2,GATM,GAMT,CHDH,ALDH7A1,BHMT,DMGDH,PIPOX,SARDH,GNMT,CBS,CBS,CTH,SDS,SDSL,SRR"]
["Glycolysis / Gluconeogenesis","Carbohydrate metabolism","HK3,HK1,HK2,HKDC1,GCK,GPI,PFKM,PFKP,PFKL,FBP1,FBP2,ALDOC,ALDOA,ALDOB,TPI1,GAPDH,GAPDHS,PGK2,PGK1,PGAM1,PGAM2,PGAM4,ENO3,ENO2,ENO1,ENO4,PKM,PKLR,PDHA2,PDHA1,PDHB,DLAT,DLD,PDHX,LDHAL6A,LDHAL6B,LDHA,LDHB,LDHC,ADH1A,ADH1B,ADH1C,ADH7,ADH4,ADH5,ADH6,AKR1A1,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,ALDH3B1,ALDH3B2,ALDH3A1,ACSS1,ACSS2,GALM,PGM1,PGM2,G6PC1,G6PC2,G6PC3,ADPGK,BPGM,MINPP1,PCK1,PCK2"]
["Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate","Glycan biosynthesis and metabolism","XYLT1,XYLT2,B4GALT7,B3GALT6,B3GAT3,CSGALNACT1,CSGALNACT2,CHSY3,CHSY1,CHPF,CHPF2,DSE,CHST11,CHST12,CHST13,CHST3,CHST7,CHST15,UST,CHST14"]
["Glycosaminoglycan biosynthesis - heparan sulfate / heparin","Glycan biosynthesis and metabolism","XYLT1,XYLT2,B4GALT7,B3GALT6,B3GAT3,EXTL2,EXTL3,EXTL1,EXT1,EXT2,NDST1,NDST2,NDST3,NDST4,GLCE,HS2ST1,HS6ST1,HS6ST2,HS6ST3,HS3ST1,HS3ST2,HS3ST3B1,HS3ST3A1,HS3ST5"]
["Glycosaminoglycan biosynthesis - keratan sulfate","Glycan biosynthesis and metabolism","FUT8,B4GALT1,B4GALT2,B4GALT3,B3GNT2,CHST6,B4GALT4,B3GNT7,CHST1,ST3GAL3,CHST2,CHST4,ST3GAL1,ST3GAL2"]
["Glycosaminoglycan degradation","Glycan biosynthesis and metabolism","HYAL2,HYAL1,SPAM1,HYAL4,HYAL3,GUSB,IDS,IDUA,ARSB,HPSE,HPSE2,SGSH,HGSNAT,NAGLU,GALNS,GLB1,GNS,HEXA,HEXB"]
["Glycosphingolipid biosynthesis - ganglio series","Glycan biosynthesis and metabolism","B4GALNT1,B3GALT4,ST3GAL2,ST3GAL1,ST8SIA5,ST3GAL5,ST8SIA1,SLC33A1,ST6GALNAC3,ST6GALNAC4,ST6GALNAC5,ST6GALNAC6,GLB1,HEXA,HEXB"]
["Glycosphingolipid biosynthesis - globo and isoglobo series","Glycan biosynthesis and metabolism","A3GALT2,B3GALNT1,GBGT1,A4GALT,GLA,B3GALT5,HEXA,HEXB,NAGA,FUT1,FUT2,ST3GAL1,ST3GAL2,ST8SIA1,FUT9"]
["Glycosphingolipid biosynthesis - lacto and neolacto series","Glycan biosynthesis and metabolism","B3GNT5,B3GALT1,B3GALT2,B3GALT5,FUT1,FUT2,FUT3,ST3GAL3,ST3GAL4,ABO,B4GALT1,B4GALT2,B4GALT3,B4GALT4,FUT9,FUT4,FUT5,FUT6,FUT7,ST3GAL6,ST8SIA1,A4GALT,B3GALNT1,B3GNT2,B3GNT3,B3GNT4,GCNT2"]
["Glycosylphosphatidylinositol (GPI)-anchor biosynthesis","Glycan biosynthesis and metabolism","PIGA,PIGC,PIGH,PIGP,PIGQ,PIGY,DPM2,PIGL,PIGW,GPLD1,PIGM,PIGX,PIGV,PIGN,PIGB,PIGO,PIGF,PIGG,GPAA1,PIGK,PIGS,PIGT,PIGU,PGAP1,MPPE1,PIGZ"]
["Glyoxylate and dicarboxylate metabolism","Carbohydrate metabolism","ACSS1,ACSS2,MDH1,MDH2,CS,ACO2,ACO1,ACAT2,ACAT1,MCEE,PCCA,PCCB,MMUT,HAO2,HAO1,CAT,GRHPR,PGP,AGXT,GLUL,SHMT2,SHMT1,GLDC,AMT,DLD,GCSH,HYI,GLYCTK,HOGA1,AFMID"]
["Histidine metabolism","Amino acid metabolism","HAL,UROC1,AMDHD1,FTCD,HDC,AOC1,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,ASPA,HNMT,MAOB,MAOA,ALDH3B1,ALDH3B2,ALDH3A1,CARNS1,CARNMT1,CNDP2,CNDP1"]
["Inositol phosphate metabolism","Carbohydrate metabolism","PIK3C3,MTM1,MTMR1,MTMR2,MTMR3,MTMR4,MTMR8,MTMR6,MTMR7,MTMR14,PI4KA,PI4KB,PI4K2A,PI4K2B,SACM1L,INPP5F,PIP5K1C,PIP5K1A,PIP5K1B,PIP5KL1,OCRL,INPP5B,INPP5E,SYNJ1,SYNJ2,PIK3CA,PIK3CD,PIK3CB,PIK3CG,PTEN,INPP5D,INPPL1,PIK3C2G,PIK3C2A,PIK3C2B,INPP4A,INPP4B,PIKFYVE,FIG4,PIP4K2C,PIP4K2A,PIP4K2B,PLCB1,PLCB2,PLCB3,PLCB4,PLCD1,PLCD3,PLCD4,PLCE1,PLCG1,PLCG2,PLCZ1,PLCH1,PLCH2,IMPA2,IMPA1,CDIPT,ISYNA1,INPP1,INPP5A,INPP5K,INPP5J,MINPP1,ITPKB,ITPKA,ITPKC,ITPK1,IPMK,IPPK,MIOX,ALDH6A1,TPI1"]
["Linoleic acid metabolism","Lipid metabolism","PLA2G10,PLA2G2D,PLA2G2E,PLA2G3,PLA2G2F,PLA2G12A,PLA2G12B,PLA2G1B,PLA2G5,PLA2G2A,PLA2G2C,PLA2G4E,PLA2G4A,JMJD7-PLA2G4B,PLA2G4B,PLA2G4C,PLA2G4D,PLA2G4F,PLA2G6,PLB1,PLAAT3,ALOX15,CYP1A2,CYP2C8,CYP2C9,CYP2C19,CYP2J2,CYP2E1,CYP3A4"]
["Lipoic acid metabolism","Metabolism of cofactors and vitamins","LIPT2,LIAS,LIPT1,ACSM1"]
["Lysine biosynthesis","Amino acid metabolism","AADAT"]
["Lysine degradation","Amino acid metabolism","AASS,ALDH7A1,AADAT,DHTKD1,DLST,DLD,GCDH,HADHA,EHHADH,ECHS1,HADH,ACAT2,ACAT1,HYKK,PHYKPL,PIPOX,CAMKMT,KMT2A,KMT2D,KMT2C,KMT2B,KMT2E,SETD1B,SETD1A,SETD7,PRDM9,PRDM7,ASH1L,SMYD2,SMYD3,SMYD1,SUV39H1,SUV39H2,EHMT2,EHMT1,SETDB1,SETDB2,PRDM2,EZH1,EZH2,SETMAR,NSD1,NSD2,NSD3,SETD2,DOT1L,KMT5A,PRDM6,KMT5C,KMT5B,MECOM,PRDM16,TMLHE,ALDH2,ALDH3A2,ALDH1B1,ALDH9A1,BBOX1,PLOD1,PLOD2,PLOD3,COLGALT1,COLGALT2"]
["Mannose type O-glycan biosynthesis","Glycan biosynthesis and metabolism","POMT1,POMT2,POMGNT1,B4GALT1,B4GALT2,B4GALT3,ST3GAL3,B3GAT1,B3GAT2,CHST10,FUT9,FUT4,MGAT5B,POMGNT2,B3GALNT2,POMK,CRPPA,FKTN,FKRP,RXYLT1,B4GAT1,LARGE1,LARGE2"]
["Metabolism of xenobiotics by cytochrome P450","Xenobiotics biodegradation and metabolism","CYP1A1,CYP2C9,CYP3A4,CYP1B1,GSTA5,GSTA2,GSTA4,GSTO2,GSTM4,GSTT2,GSTT1,GSTM3,MGST1,MGST3,GSTM1,GSTM5,MGST2,GSTA1,GSTM2,GSTA3,GSTO1,GSTT2B,GSTP1,GSTK1,HPGDS,EPHX1,CYP2B6,SULT2A1,CYP1A2,CYP2A6,CYP2A7,CYP2E1,CYP2F1,CYP2S1,AKR1C1,DHDH,CYP2A13,CYP2D6,CYP2D7,CYP2D6,HSD11B1,HSD11B1L,CBR1,CBR3,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,CYP3A5,AKR7A2,AKR7A3,AKR7L,ALDH3B1,ALDH3B2,ALDH3A1,ADH1A,ADH1B,ADH1C,ADH7,ADH4,ADH5,ADH6"]
["Monobactam biosynthesis","Biosynthesis of other secondary metabolites","PAPSS2,PAPSS1"]
["Mucin type O-glycan biosynthesis","Glycan biosynthesis and metabolism","GALNTL6,GALNT5,GALNT17,GALNT11,GALNT12,GALNT13,GALNT14,GALNT16,GALNT15,GALNT18,GALNTL5,GALNT10,GALNT2,GALNT3,GALNT1,GALNT6,GALNT4,GALNT9,GALNT7,GALNT8,POC1B-GALNT4,C1GALT1,C1GALT1C1,C1GALT1C1L,GCNT1,GCNT3,GCNT4,ST3GAL1,ST3GAL2,ST6GALNAC1,ST6GALNAC2,ST6GALNAC3,ST6GALNAC4,B3GNT3,B3GNT6,B4GALT5"]
["N-Glycan biosynthesis","Glycan biosynthesis and metabolism","SRD5A3,DOLK,DPAGT1,ALG5,ALG13,ALG14,DPM1,DPM2,DPM3,ALG1,ALG2,ALG11,ALG3,ALG9,ALG12,ALG6,ALG8,ALG10,ALG10B,STT3A,STT3B,RPN1,RPN2,DAD1,TUSC3,DDOST,DOLPP1,MOGS,GANAB,MAN1B1,MAN1A2,MAN1C1,MAN1A1,MGAT1,MAN2A1,MAN2A2,MGAT2,FUT8,B4GALT1,B4GALT2,B4GALT3,ST6GAL1,ST6GAL2,MGAT3,MGAT4A,MGAT4B,MGAT4D,MGAT5,MGAT5B,MGAT4C"]
["Neomycin, kanamycin and gentamicin biosynthesis","Biosynthesis of other secondary metabolites","HK3,HK1,HK2,HKDC1,GCK"]
["Nicotinate and nicotinamide metabolism","Metabolism of cofactors and vitamins","ASPDH,QPRT,NAPRT,PNP,NMRK1,NMRK2,NT5C2,NT5C1A,NT5C1B,NT5C,NT5M,NT5C1B-RDH14,NT5E,NMNAT3,NMNAT1,NMNAT2,ENPP1,ENPP3,NUDT12,NADSYN1,NAMPT,CD38,BST1,SIRT1,SIRT2,SIRT3,SIRT4,SIRT5,SIRT6,SIRT7,NADK,NADK2,NNT,NNMT,AOX1"]
["Nitrogen metabolism","Energy metabolism","GLUD2,GLUD1,GLUL,CPS1,CA13,CA1,CA6,CA7,CA12,CA5B,CA14,CA9,CA3,CA5A,CA8,CA2,CA4"]
["One carbon pool by folate","Metabolism of cofactors and vitamins","DHFR,DHFR2,MTHFD1L,MTHFD1,MTHFD2,MTHFD2L,SHMT2,SHMT1,GART,ATIC,FTCD,MTFMT,AMT,MTR,TYMS,ALDH1L1,ALDH1L2,MTHFR,MTHFS,ST20-MTHFS"]
["Other glycan degradation","Glycan biosynthesis and metabolism","NEU1,NEU3,NEU4,NEU2,GLB1,HEXA,HEXB,HEXD,MAN2C1,MAN2B1,MAN2B2,MANBA,ENGASE,FUCA1,FUCA2,AGA,GBA,GBA2"]
["Other types of O-glycan biosynthesis","Glycan biosynthesis and metabolism","OGT,EOGT,POFUT1,POFUT2,MFNG,LFNG,RFNG,B4GALT1,B4GALT2,B4GALT3,ST6GAL1,ST6GAL2,ST3GAL3,B3GLCT,POGLUT1,GXYLT1,GXYLT2,XXYLT1,COLGALT1,COLGALT2,PLOD3,POMT1,POMT2,GALNTL6,GALNT5,GALNT17,GALNT11,GALNT12,GALNT13,GALNT14,GALNT16,GALNT15,GALNT18,GALNTL5,GALNT10,GALNT2,GALNT3,GALNT1,GALNT6,GALNT4,GALNT9,GALNT7,GALNT8,POC1B-GALNT4,C1GALT1,C1GALT1C1,C1GALT1C1L"]
["Oxidative phosphorylation","Energy metabolism","ND1,ND2,ND3,ND4,ND4L,ND5,ND6,NDUFS1,NDUFS2,NDUFS3,NDUFS4,NDUFS5,NDUFS6,NDUFS7,NDUFS8,NDUFV1,NDUFV2,NDUFV3,NDUFA1,NDUFA2,NDUFA3,NDUFA4,NDUFA4L2,NDUFA5,NDUFA6,NDUFA7,NDUFA8,NDUFA9,NDUFA10,NDUFAB1,NDUFA11,NDUFA12,NDUFA13,NDUFB1,NDUFB2,NDUFB3,NDUFB4,NDUFB5,NDUFB6,NDUFB7,NDUFB8,NDUFB9,NDUFB10,NDUFB11,NDUFC1,NDUFC2,NDUFC2-KCTD14,SDHA,SDHB,SDHC,SDHD,UQCRFS1,CYTB,CYC1,UQCRC1,UQCRC2,UQCRH,UQCRHL,UQCRB,UQCRQ,UQCR10,UQCR11,COX10,COX3,COX1,COX2,COX4I2,COX4I1,COX5A,COX5B,COX6A1,COX6A2,COX6B1,COX6B2,COX6C,COX7A1,COX7A2,COX7A2L,COX7B,COX7B2,COX7C,COX8C,COX8A,COX11,COX15,COX17,CYCS,ATP5F1A,ATP5F1B,ATP5F1C,ATP5F1D,ATP5F1E,ATP5PO,ATP6,ATP5PB,ATP5MC1,ATP5MC2,ATP5MC3,ATP5PD,ATP5ME,ATP5MF,ATP5MG,ATP5PF,ATP8,ATP6V1A,ATP6V1B1,ATP6V1B2,ATP6V1C2,ATP6V1C1,ATP6V1D,ATP6V1E2,ATP6V1E1,ATP6V1F,ATP6V1G1,ATP6V1G3,ATP6V1G2,ATP6V1H,TCIRG1,ATP6V0A2,ATP6V0A4,ATP6V0A1,ATP6V0C,ATP6V0B,ATP6V0D1,ATP6V0D2,ATP6V0E1,ATP6V0E2,ATP6AP1,ATP4A,ATP4B,ATP12A,PPA2,PPA1,LHPP"]
["Pantothenate and CoA biosynthesis","Metabolism of cofactors and vitamins","PANK1,PANK3,PANK2,PPCS,PPCDC,ENPP1,ENPP3,COASY,AASDHPPT,VNN1,VNN2,BCAT2,BCAT1,DPYD,DPYS,UPB1,GADL1,CSAD,ALDH2,ALDH3A2,ALDH1B1"]
["Penicillin and cephalosporin biosynthesis","Biosynthesis of other secondary metabolites","DAO"]
["Pentose and glucuronate interconversions","Carbohydrate metabolism","GUSB,KL,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,UGDH,UGP2,AKR1A1,CRYL1,RPE,RPEL1,XYLB,AKR1B1,AKR1B10,DCXR,SORD,DHDH,CRPPA"]
["Pentose phosphate pathway","Carbohydrate metabolism","GPI,G6PD,PGLS,H6PD,PGD,RPE,RPEL1,TKT,TKTL2,TKTL1,TALDO1,RPIA,DERA,RBKS,PGM1,PGM2,PRPS1L1,PRPS2,PRPS1,RGN,IDNK,GLYCTK,ALDOC,ALDOA,ALDOB,FBP1,FBP2,PFKM,PFKP,PFKL"]
["Phenylalanine metabolism","Amino acid metabolism","PAH,DDC,AOC3,AOC2,MAOB,MAOA,ALDH3B1,ALDH3B2,ALDH3A1,GOT1,GOT1L1,GOT2,TAT,IL4I1,HPD,MIF,GLYAT"]
["Phenylalanine, tyrosine and tryptophan biosynthesis","Amino acid metabolism","GOT1,GOT1L1,GOT2,TAT,IL4I1,PAH"]
["Phosphonate and phosphinate metabolism","Metabolism of other amino acids","PCYT2,SELENOI,CEPT1,PCYT1B,PCYT1A,CHPT1"]
["Polyketide sugar unit biosynthesis","Metabolism of terpenoids and polyketides","TGDS"]
["Porphyrin and chlorophyll metabolism","Metabolism of cofactors and vitamins","ALAS1,ALAS2,EARS2,EPRS1,ALAD,HMBS,UROS,UROD,CPOX,PPOX,FECH,COX10,COX15,MMAB,HMOX1,HMOX2,BLVRA,BLVRB,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,GUSB,HCCS,CP,HEPH,HEPHL1,FXN"]
["Primary bile acid biosynthesis","Lipid metabolism","CYP46A1,CYP39A1,HSD3B7,CH25H,CYP7B1,CYP7A1,CYP27A1,CYP8B1,AKR1D1,AKR1C4,SLC27A5,AMACR,ACOX2,HSD17B4,SCP2,ACOT8,BAAT"]
["Prodigiosin biosynthesis","Biosynthesis of other secondary metabolites","MCAT"]
["Propanoate metabolism","Carbohydrate metabolism","ACSS1,ACSS2,ACSS3,BCKDHA,BCKDHB,DBT,DLD,ACADS,ACOX3,ACOX1,HADHA,EHHADH,ECHS1,HIBCH,ACACA,ACACB,MLYCD,ABAT,PCCA,PCCB,ECHDC1,MCEE,MMUT,SUCLG1,SUCLG2,SUCLA2,ALDH6A1,LDHAL6A,LDHAL6B,LDHA,LDHB,LDHC"]
["Purine metabolism","Nucleotide metabolism","NUDT9,ADPRM,NUDT5,PGM1,PGM2,PRPS1L1,PRPS2,PRPS1,PPAT,GART,PFAS,PAICS,ADSL,ATIC,APRT,NT5C2,NT5C1A,NT5C1B,NT5C,NT5M,NT5C1B-RDH14,NT5E,PNP,HPRT1,IMPDH1,IMPDH2,NME6,NME7,NME2,NME4,NME1,NME3,NME1-NME2,AK9,ENTPD3,ENTPD8,ENTPD1,CANT1,ENTPD4,ENTPD5,ENTPD6,NUDT16,ITPA,XDH,NUDT2,GMPS,GMPR,GMPR2,GDA,GUK1,RRM1,RRM2B,RRM2,HDDC2,DGUOK,DCK,HDDC3,PRUNE1,ADCY1,ADCY2,ADCY3,ADCY4,ADCY5,ADCY6,ADCY7,ADCY8,ADCY9,ADCY10,GUCY1A2,GUCY1A1,GUCY1B1,GUCY2C,GUCY2D,GUCY2F,NPR1,NPR2,PDE1A,PDE1B,PDE1C,PDE2A,PDE3A,PDE3B,PDE5A,PDE6A,PDE6B,PDE6C,PDE6D,PDE6G,PDE6H,PDE9A,PDE10A,PDE11A,ADSS1,ADSS2,AMPD2,AMPD3,AMPD1,ADK,ADA,ADA2,AK7,AK4,AK5,AK2,AK1,AK8,AK6,AK3,ENTPD2,NTPCR,PDE4A,PDE4B,PDE4C,PDE4D,PDE7A,PDE7B,PDE8B,PDE8A,FHIT,ENPP4,PAPSS2,PAPSS1,ENPP1,ENPP3,URAD,ALLC"]
["Pyrimidine metabolism","Nucleotide metabolism","CAD,DHODH,UMPS,CMPK1,CMPK2,NME6,NME7,NME2,NME4,NME1,NME3,NME1-NME2,AK9,ENTPD3,ENTPD8,ENTPD1,CANT1,ENTPD4,ENTPD5,ENTPD6,CTPS1,CTPS2,UCK1,UCK2,UCKL1,NT5C2,NT5C1A,NT5C1B,NT5C,NT5M,NT5C1B-RDH14,NT5E,NT5C3A,NT5C3B,UPP2,UPP1,DPYD,DPYS,UPB1,ENPP1,ENPP3,RRM1,RRM2B,RRM2,DCTPP1,DUT,TYMS,CDA,TYMP,PNP,DCK,DCTD,TK2,TK1,DTYMK,NUDT2"]
["Pyruvate metabolism","Carbohydrate metabolism","ACSS1,ACSS2,PDHA2,PDHA1,PDHB,DLAT,DLD,PDHX,ADH1A,ADH1B,ADH1C,ADH7,ADH4,ADH6,ADH5,AKR1A1,PKM,PKLR,ACACA,ACACB,ACYP2,ACYP1,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,ACOT12,LDHAL6A,LDHAL6B,LDHA,LDHB,LDHC,LDHD,GLO1,HAGH,GRHPR,ME2,ME3,ME1,PC,MDH1,MDH2,FH,PCK1,PCK2,ACAT2,ACAT1"]
["Retinol metabolism","Metabolism of cofactors and vitamins","BCO1,ADH1A,ADH1B,ADH1C,ADH7,ADH4,ADH5,ADH6,DHRS3,DHRS4,DHRS4L2,DHRS9,RDH8,RDH10,RDH11,RDH12,RDH13,RDH16,SDR16C5,HSD17B6,LRAT,DGAT1,AWAT2,PNPLA4,RPE65,RDH5,AOX1,ALDH1A2,ALDH1A1,ALDH1A3,CYP26A1,CYP26B1,CYP26C1,CYP1A1,CYP1A2,CYP2A6,CYP2A7,CYP2B6,CYP2C8,CYP2C9,CYP2C18,CYP2S1,CYP3A4,CYP3A5,CYP3A7,CYP3A7-CYP3A51P,CYP2W1,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,RETSAT,CYP27C1"]
["Riboflavin metabolism","Metabolism of cofactors and vitamins","RFK,ACP5,ACP1,ACP2,FLAD1,ENPP1,ENPP3,BLVRB"]
["Selenocompound metabolism","Metabolism of other amino acids","KYAT3,KYAT1,MTR,CTH,SCLY,TXNRD1,TXNRD3,TXNRD2,INMT,PAPSS2,PAPSS1,SEPHS2,SEPHS1,PSTK,SEPSECS,MARS1,MARS2"]
["Sphingolipid metabolism","Lipid metabolism","SPTLC1,SPTLC2,SPTLC3,KDSR,CERS1,CERS2,CERS4,CERS3,CERS6,CERS5,ASAH1,ASAH2,ACER2,ACER1,ACER3,DEGS1,DEGS2,SGMS1,SGMS2,SMPD1,SMPD2,SMPD3,SMPD4,ENPP7,CERK,PLPP1,PLPP3,PLPP2,SGPP1,SGPP2,SPHK1,SPHK2,SGPL1,UGCG,GBA,GBA2,B4GALT6,GLB1,UGT8,GALC,GAL3ST1,ARSA,NEU1,NEU3,NEU4,NEU2,GLA,PSAP,PSAPL1"]
["Starch and sucrose metabolism","Carbohydrate metabolism","MGAM,MGAM2,GAA,GANC,SI,UGP2,ENPP1,ENPP3,GBA3,GYS2,GYS1,GYG1,GYG2,GBE1,PYGL,PYGM,PYGB,AGL,AMY1C,AMY2A,AMY1A,AMY2B,AMY1B,TREH,PGM1,PGM2,HK3,HK1,HK2,HKDC1,GCK,G6PC1,G6PC2,G6PC3,PGM2L1,GPI"]
["Steroid biosynthesis","Lipid metabolism","FDFT1,SQLE,LSS,CYP51A1,TM7SF2,LBR,MSMO1,NSDHL,HSD17B7,EBP,DHCR24,SC5D,DHCR7,LIPA,CEL,SOAT2,SOAT1,CYP2R1,CYP27B1,CYP24A1"]
["Steroid hormone biosynthesis","Lipid metabolism","CYP11A1,CYP17A1,STS,SULT2B1,CYP21A2,HSD3B1,HSD3B2,SRD5A1,SRD5A2,SRD5A3,AKR1C2,AKR1C3,CYP11B1,CYP11B2,AKR1D1,AKR1C4,HSD11B1,HSD11B1L,HSD11B2,AKR1C1,CYP7B1,SULT1E1,HSD17B1,HSD17B2,HSD17B6,HSD17B7,HSD17B8,HSD17B12,DHRS11,CYP1A1,CYP1A2,CYP3A5,CYP3A7,CYP3A7-CYP3A51P,CYP2E1,CYP3A4,CYP1B1,CYP19A1,CYP7A1,UGT2A1,UGT2A3,UGT2B17,UGT2B11,UGT2B28,UGT1A6,UGT1A4,UGT1A1,UGT1A3,UGT2B10,UGT1A9,UGT2B7,UGT1A10,UGT1A8,UGT1A5,UGT2B15,UGT1A7,UGT2B4,UGT2A2,COMT,LRTOMT,HSD17B3"]
["Sulfur metabolism","Energy metabolism","PAPSS2,PAPSS1,BPNT1,BPNT2,SUOX,SQOR,ETHE1,MPST,TST,SELENBP1"]
["Taurine and hypotaurine metabolism","Metabolism of other amino acids","CDO1,GAD1,GAD2,GADL1,CSAD,ADO,GGT7,GGT6,GGT1,GGT5,BAAT"]
["Terpenoid backbone biosynthesis","Metabolism of terpenoids and polyketides","ACAT2,ACAT1,HMGCS1,HMGCS2,HMGCR,MVK,PMVK,MVD,IDI1,IDI2,FDPS,GGPS1,PDSS1,PDSS2,DHDDS,NUS1,FNTA,FNTB,RCE1,ZMPSTE24,ICMT,PCYOX1"]
["Thiamine metabolism","Metabolism of cofactors and vitamins","NFS1,NTPCR,ALPL,ALPI,ALPP,ALPG,ACP1,TPK1,AK7,AK4,AK5,AK2,AK1,AK8,THTPA"]
["Tryptophan metabolism","Amino acid metabolism","TDO2,IDO1,IDO2,AFMID,KMO,KYNU,HAAO,ACMSD,ALDH8A1,DHTKD1,DLST,DLD,GCDH,HADHA,EHHADH,ECHS1,HADH,ACAT2,ACAT1,KYAT3,KYAT1,AADAT,TPH2,TPH1,DDC,MAOB,MAOA,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,AOX1,ASMT,AANAT,CYP1A1,CYP1A2,CYP1B1,INMT,IL4I1,AOC1,CAT"]
["Tyrosine metabolism","Amino acid metabolism","GOT1,GOT1L1,GOT2,TAT,IL4I1,HPD,HGD,GSTZ1,FAH,TYR,TH,DCT,TYRP1,DDC,DBH,PNMT,COMT,LRTOMT,MAOB,MAOA,AOC3,AOC2,ALDH3B1,ALDH3B2,ALDH3A1,ADH1A,ADH1B,ADH1C,ADH7,ADH4,ADH5,ADH6,TPO,AOX1,FAHD1,MIF"]
["Ubiquinone and other terpenoid-quinone biosynthesis","Metabolism of cofactors and vitamins","TAT,COQ2,COQ6,COQ3,COQ5,COQ7,NQO1,GGCX,VKORC1,VKORC1L1,HPD"]
["Valine, leucine and isoleucine biosynthesis","Amino acid metabolism","SDS,SDSL,BCAT2,BCAT1"]
["Valine, leucine and isoleucine degradation","Amino acid metabolism","BCAT2,BCAT1,IL4I1,BCKDHA,BCKDHB,DBT,DLD,ACADS,ACADM,IVD,ACADSB,ACAD8,HADHA,EHHADH,ECHS1,HADH,HSD17B10,ACAA1,ACAA2,HADHB,PCCA,PCCB,MCEE,MMUT,HIBCH,HIBADH,ALDH6A1,ALDH2,ALDH3A2,ALDH1B1,ALDH7A1,ALDH9A1,AOX1,ACSF3,ABAT,AGXT2,MCCC1,MCCC2,AUH,HMGCL,HMGCLL1,OXCT1,OXCT2,AACS,ACAT2,ACAT1,HMGCS1,HMGCS2"]
["Various types of N-glycan biosynthesis","Glycan biosynthesis and metabolism","ALG13,ALG14,ALG1,ALG2,ALG11,ALG3,ALG9,ALG12,STT3A,STT3B,RPN1,RPN2,DAD1,TUSC3,DDOST,MAN1B1,MAN1A2,MAN1C1,MAN1A1,MGAT1,MAN2A1,MAN2A2,MGAT2,HEXA,HEXB,FUT8,HEXD,MGAT4C,MGAT4A,MGAT4B,MGAT4D,B4GALT1,B4GALT2,B4GALT3,ST3GAL3,B4GALNT3,B4GALNT4,CHST8,CHST9"]
["Vitamin B6 metabolism","Metabolism of cofactors and vitamins","PNPO,PDXK,PDXP,PHOSPHO2,AOX1,PSAT1"]

{"sheet":"Supplementary_Table18","index":17,"n_rows":12,"n_cols":5,"rows_kept":12,"merged":[[0,0,0,11]]}
["Corresponding data of the t-SNE representation of the Puram et al. malignant single-cell data (number of cells and proportion of cells per MPS and patient). "]
["patient","MPS1 cell num.","MPS2 cell num.","MPS1 cell prop.","MPS2 cell prop."]
["HNSCC5",55,12,"0.82","0.18"]
["HNSCC6",67,56,"0.54","0.46"]
["HNSCC16",54,2,"0.96","0.04"]
["HNSCC17",200,130,"0.61","0.39"]
["HNSCC18",139,1,"0.99","0.01"]
["HNSCC20",41,280,"0.13","0.87"]
["HNSCC22",118,1,"0.99","0.01"]
["HNSCC25",112,1,"0.99","0.01"]
["HNSCC26",27,1,"0.96","0.04"]
["HNSCC28",10,6,"0.63","0.37"]

{"sheet":"Supplementary_Table_STR_typing","index":18,"n_rows":7,"n_cols":21,"rows_kept":7}
[null,"Cell line","Date","D5","D5'","D13","D13'","D7","D7'","D16","D16'","vWA","vWA'","TH01","TH01'","TPOX","TPOX'","CSF1","CSF1'","Amel","Amel'"]
["DSMZ (ACC 447)","CAL-33","2008-07-18",11,12,8,13,8,10,11,11,17,17,9,9.3,8,8,11,12,"X","Y"]
["Orth Klinikum der Universität München, Klink und Poliklinik für Strahlentherapie und Radiologie","Cal-33","2015-10-21",11,12,8,13,8,10,11,11,17,17,9,9.3,8,8,11,12,"X","Y"]
[]
["DSMZ (ACC 668)","UPCI-SCC-131","2010-02-01",11,11,11,13,11,12,13,13,15,"17","7","9",11,11,12,12,"X","Y"]
["Orth Klinikum der Universität München, Klink und Poliklinik für Strahlentherapie und Radiologie","UPCI-SCC-131","2015-10-21",11,11,11,13,11,12,13,13,15,17,7,9,11,11,12,12,"X","Y"]
["STR-profile of analysed sample"]