Figure 1																																					
Fig. 1E																																					
Wild-type	W1044X	S1444R	_agl-1Ê																																		
104.0718	113.7602	109.0957	115.5611																																		
107.3396	107.5233	103.3468	112.5364																																		
106.8976	109.6291	105.2908	107.5008																																		
109.195	106.4322	102.3385	111.9155																																		
101.1096	104.1594	100.2354	106.9649																																		
101.4521	102.4804	100.5441	119.5399																																		
89.65525	108.0406	105.193	118.8174																																		
100.0407	104.4996	102.487	118.8174																																		
99.25697	116.2031	110.9572	115.5703																																		
99.18235	103.6373	97.3195	114.9487																																		
98.3368	111.9964	107.4726	131.1486																																		
96.74506	108.6125	104.3527	124.6122																																		
104.1213	112.9553	108.3552	115.5611																																		
95.04985	108.2524	104.0202	112.5364																																		
96.02637	110.3872	105.9899	107.5008																																		
97.87138	107.8705	103.6676	111.9155																																		
88.95832	111.4297	106.9506	106.9649																																		
103.3977	105.8788	101.8267	119.5399																																		
106.6227	109.5231	105.193	118.8174																																		
106.8976	103.1492	99.29957	118.8174																																		
105.584	124.2388	117.8204	115.5703																																		
99.84485	104.3145	99.13246	114.9487																																		
100.1788	110.4467	107.4726	141.1486																																		
89.15455	109.3565	105.0393	124.6122																																		
99.41768																																					
99.25697																																					
99.80241																																					
98.94629																																					
95.58653																																					
																																					
Fig. 1F																																					
Wild-type	W1044X	S1444R	_agl-1																																		
4.1	4.06	4.76	5.94																																		
3.97	5.49	6.7	5.737																																		
1.926	4.757	3.275	4.101																																		
1.124	2.053	4.156	4.648																																		
1.391	5.225	2.934	3.682																																		
2.722	8.97	8.819	4.485																																		
3.876	3.65	7.487	7.425																																		
2.819	8.41	6.27	9.352																																		
1.545			8.854																																		
1.163			5.373																																		
1.155																																					
1.519																																					
3.437																																					
2.336																																					
4.405																																					
2.362																																					
1.705																																					
5.968																																					
3.25																																					
																																					
																																					
Fig. 1G																																					
N2	W1044XÊ	S1444R	_agl-1																																		
100		0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100		0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
																																					
																																					
																																					
100	0	0	25																																		
100		0	22.22222222																																		
100	0	6	11.94029851																																		
100	53.84615385	0	0																																		
100	21.05263158	122.7272727	12.24489796																																		
100	0.740740741	33.33333333	1.869158879																																		
100	0		2.272727273																																		
100	0	0	5.714285714																																		
100	0		0																																		
100	0	0	6.818181818																																		
																																					
																																					
																																					
100		0	100																																		
100	3.125	111.1111111	100																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	1.851851852	6.557377049																																		
100	2.380952381		0																																		
100	7.692307692	29.41176471	3.773584906																																		
100	12.5		68.18181818																																		
100	6.976744186	0	17.94871795																																		
100	4.819277108		17.77777778																																		
																																					
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100		0	0																																		
	0	0	0																																		
100	8.333333333	0	0																																		
	0	0	0																																		
																																					
																																					
																																					
100	0	0	55.17241379																																		
100	0	0	0																																		
100	0	0	0																																		
100	14.81481481	11.50442478	81.81818182																																		
100	2.666666667	0	0																																		
100		55.40540541	2.173913043																																		
100	100	19.48051948	2.173913043																																		
100	0.943396226	27.39726027																																			
100	1.754385965	0	0																																		
100	0	2.597402597																																			
																																					
																																					
																																					
100	29.57746479	100	33.33333333																																		
100	97.91666667	93.5483871	14.81481481																																		
100	89.39393939	100	76.08695652																																		
100	87.5	100	84.48275862																																		
100	83.78378378	0	0																																		
100	24.61538462	100	100																																		
100	100	56.52173913	100																																		
100	22.44897959	100	73.58490566																																		
100		47.05882353	50																																		
100	14.08450704	61.76470588																																			
			0																																		
100	15.38461538	0	0																																		
100	0	75	0																																		
100	0	54.83870968	0																																		
100	0	18.75	0																																		
100	0	76.47058824	0																																		
100	0	0	0																																		
100	0	0	0																																		
100	0	0	0																																		
100		0	0																																		
100		0																																			
			0																																		
	33.33333333		1.408450704																																		
	0		24.24242424																																		
100	0	89.53488372	0																																		
100	10.90909091	100	79.10447761																																		
100	32.14285714	64.28571429	0																																		
100	20.27027027	70.14925373	45.28301887																																		
100	100	17.64705882	94.54545455																																		
100	100	10.29411765	0																																		
100	25	14.28571429	100																																		
100	9.756097561	42.85714286																																			
100		36.76470588																																			
100	0	35.41666667																																			
	0		21.25																																		
	0		83.33333333																																		
	0		94.33962264																																		
100	35.29411765	100	12.65822785																																		
100	0	100	100																																		
100	0	100	2.941176471																																		
100	0	96.15384615	4.761904762																																		
100	0	81.25	17.77777778																																		
100	11.11111111	65	78.125																																		
100		100	0																																		
100	0	53.125																																			
100	0	66.66666667																																			
100	0	48.38709677																																			
	0																																				
	0																																				
	0																																				
	0																																				
	0																																				
	0																																				
	0																																				
	0																																				
	0																																				
	0																																				
																																					
Fig. 1H																																					
N2	W1044XÊ	S1444R	_agl-1																																		
66.43333333	64.9	44.5	41.83333333																																		
54.94166667	29.23333333	39.5	34.95555556																																		
55.33333333	50.70833333	42.03333333	34.56666667																																		
																																					
Figure 2																																					
Fig. 2A																																					
Days of adulthood	Wild-type	agl-1(W1044X)	agl-1(S1444R)	agl-1(knu867)																																	
5	0	0																																			
5	0	0																																			
5	0																																				
7	0	0	1																																		
7	0	0	1																																		
7	0	0	1																																		
7	0	0	1																																		
7	0	0																																			
7	1																																				
11	0	0																																			
11	0	0																																			
11	0	0																																			
11	0	0																																			
11	0																																				
13	0	1																																			
13	0	1																																			
13	1	1																																			
13	1	1																																			
13	1	1																																			
13	1	1																																			
13	1	1																																			
13	1	1																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1																																				
13	1																																				
13	1																																				
13	1																																				
13	1																																				
13	1																																				
15	0	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
17	0	1																																			
17	0	1																																			
17	0	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	0																																			
17	1	0																																			
17	1	0																																			
17	1	0																																			
17	1	0																																			
17	1	0																																			
17	1	0																																			
17	1	0																																			
17	1																																				
17	1																																				
17	1																																				
17	1																																				
19	0	1																																			
19	0	1																																			
19	0	1																																			
19	0	1																																			
19	0	1																																			
19	0	1																																			
19	0	1																																			
21	1	1																																			
21	1	1																																			
21	1																																				
21	1																																				
21	1																																				
21	1																																				
21	1																																				
23	0	1																																			
23	0	1																																			
23	0	1																																			
23	1																																				
23	1																																				
25	1																																				
25	1																																				
25	1																																				
25	1																																				
25	1																																				
25	0																																				
25	0																																				
25	0																																				
27	1	1																																			
27	1																																				
27	1																																				
27	1																																				
27	1																																				
29	1																																				
29	1																																				
29	1																																				
31	1	1																																			
31	1																																				
31	1																																				
31	1																																				
31	1																																				
31	1																																				
31	1																																				
31	1																																				
31	1																																				
11	0																																				
11	0																																				
11	0																																				
11	0																																				
13	0	0																																			
13	0	0																																			
13	0	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
13	1	0																																			
15	0	0																																			
15	0	0																																			
15	1	0																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
15	1	1																																			
17	1	0																																			
17	1	0																																			
17	1	0																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1	1																																			
17	1																																				
17	1																																				
17	1																																				
17	1																																				
17	1																																				
17	1																																				
17	1																																				
17	0																																				
17	0																																				
17	0																																				
17	0																																				
17	0																																				
17	0																																				
17	0																																				
17	0																																				
19	0	1																																			
19	0	1																																			
19	0	1																																			
19	1	1																																			
19	1	1																																			
19	1	1																																			
19	1	1																																			
19	1	1																																			
19	1	1																																			
19	1	1																																			
19	1																																				
19	1																																				
19	1																																				
19	1																																				
21	0	0																																			
21	0	0																																			
21	0	0																																			
21	0	0																																			
21	0	1																																			
21	0	1																																			
21	0	1																																			
21	1	1																																			
21	1	1																																			
21	1	1																																			
21	1	1																																			
21	1	1																																			
21	1	1																																			
21	1																																				
21	1																																				
21	1																																				
21	1																																				
21	1																																				
21	1																																				
21	1																																				
21	1																																				
21	1																																				
23	1	1																																			
23	1	1																																			
23	1	1																																			
23	1	1																																			
23	1	1																																			
23	1																																				
23	1																																				
23	1																																				
23	1																																				
23	1																																				
23	1																																				
25	1	1																																			
25	1																																				
25	1																																				
25	1																																				
25	1																																				
25	1																																				
25	1																																				
25	1																																				
25	1																																				
25	1																																				
27	1																																				
27	1																																				
27	1																																				
27	1																																				
27	1																																				
29	1																																				
29	1																																				
9		1	1	0																																	
9		1	1	0																																	
9		1	1	1																																	
9		1	1	1																																	
9		1	1	1																																	
9		1	0	1																																	
9		1	0	1																																	
9		0	0	1																																	
9		0	0	1																																	
9		0	0	1																																	
9		0		1																																	
9		0		1																																	
9		0		1																																	
9		0		1																																	
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0		1																																	
9		0		1																																	
9		0		1																																	
9		0		1																																	
9		0		1																																	
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
9		0																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
7		0																																			
7		0																																			
7		0																																			
9		0																																			
11		0	0	1																																	
11		0	0	1																																	
11		0	1	1																																	
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0	1																																		
11		0																																			
11		0																																			
11		0																																			
13		1	0																																		
13		1	0																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1	1																																		
13		1																																			
15		1	1																																		
15		1	1																																		
15		1	1																																		
15		1	1																																		
15		1																																			
5		0		0																																	
5		0		0																																	
5		0		0																																	
5		0		0																																	
5		0		0																																	
5		0		0																																	
7		1		1																																	
7		1		0																																	
7		0		0																																	
7		0		0																																	
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
7		0																																			
9		1																																			
9		0																																			
9		0																																			
11		0																																			
11		0																																			
11		0																																			
11		0																																			
11		0																																			
11		0																																			
11		0																																			
11		0																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
11		1																																			
13		0																																			
13		0																																			
13		0																																			
13		0																																			
13		1																																			
13		1																																			
13		1																																			
13		1																																			
13		1																																			
13		1																																			
13		1																																			
13		1																																			
15		0																																			
15		0																																			
15		0																																			
15		0																																			
15		0																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
15		1																																			
17		0	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1	1																																		
17		1																																			
19		1																																			
19		1																																			
19		0																																			
21		1																																			
21		1																																			
21		1																																			
21		1																																			
21		1																																			
21		0																																			
23		1																																			
25		1																																			
25		1																																			
25		1																																			
27		1																																			
5			0																																		
5			0																																		
5			0																																		
5			0																																		
5			0																																		
5			0																																		
5			0																																		
5			0																																		
7			0																																		
7			0																																		
7			0																																		
7			0																																		
7			1																																		
7			1																																		
7			1																																		
7			1																																		
7			1																																		
7			1																																		
7			1																																		
9			1	0																																	
9			1	0																																	
9			1	1																																	
9			1	1																																	
9			1	1																																	
9			1	1																																	
9			1	1																																	
9			1	1																																	
9			1	1																																	
11			1																																		
11			1																																		
11			1																																		
11			1																																		
11			1																																		
11			1																																		
11			1																																		
11			1																																		
11			1																																		
11			0																																		
11			0																																		
11			0																																		
11			0																																		
11			0																																		
11			0																																		
11			0																																		
11			0																																		
13			1																																		
13			1																																		
13			1																																		
13			1																																		
13			1																																		
13			1																																		
13			1																																		
13			1																																		
13			1																																		
13			0																																		
13			0																																		
15			1																																		
15			1																																		
15			1																																		
15			1																																		
15			1																																		
15			1																																		
15			1																																		
15			1																																		
15			0																																		
17			0																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
17			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
23			1																																		
23			1																																		
23			1																																		
23			1																																		
23			1																																		
23			1																																		
25			1																																		
25			1																																		
27			1																																		
27			1																																		
31			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
19			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
21			0																																		
21			0																																		
23			1																																		
23			0																																		
25			1																																		
25			1																																		
25			1																																		
25			1																																		
25			1																																		
25			0																																		
27			1																																		
31			1																																		
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
15				1																																	
15				1																																	
15				1																																	
15				1																																	
15				1																																	
15				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
23				1																																	
23				1																																	
25				1																																	
27				1																																	
29				1																																	
31				1																																	
31				1																																	
9				0																																	
9				0																																	
9				0																																	
11				1																																	
11				1																																	
11				1																																	
11				1																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
11				0																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				1																																	
13				0																																	
15				1																																	
15				1																																	
15				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
17				0																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
19				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				0																																	
21				0																																	
21				0																																	
21				0																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
23				1																																	
25				1																																	
25				1																																	
25				1																																	
25				1																																	
25				1																																	
25				1																																	
25				1																																	
25				1																																	
25				1																																	
27				1																																	
27				1																																	
27				1																																	
29				1																																	
7	0		0	1																																	
7	0		0	1																																	
7	0		1	1																																	
7	0		1	1																																	
7	0		1	0																																	
7	0		1	0																																	
7	0		1	0																																	
7	0		1	0																																	
7	0			0																																	
7	0			0																																	
7	0			0																																	
9	0		1	0																																	
9	0		1	0																																	
9	0		1	0																																	
9	0		1	0																																	
9	0		0	0																																	
9	0		0	0																																	
9	0		0																																		
11	1		1	1																																	
11	1		1	1																																	
11	1		1	1																																	
11	1		1	1																																	
11	1		1	1																																	
11	1		1	1																																	
11	1		1	1																																	
11	1		1	1																																	
11	1		1	1																																	
11	1		1																																		
11	0		1																																		
11	0		1																																		
11	0		1																																		
11	0		1																																		
11	0		1																																		
11	0		1																																		
11	0		1																																		
11	0		1																																		
13	1		1	1																																	
13	1		1	1																																	
13	1		1	1																																	
13	1		1	1																																	
13	1		1																																		
13	1		1																																		
13	1		1																																		
13	1		1																																		
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	1		1	1																																	
15	0		1	0																																	
15	0		1	0																																	
15	0		0	0																																	
15	0		0	0																																	
17	1		1	0																																	
17	1		1	0																																	
17	1		1	0																																	
17	1		1	1																																	
17	1		1	1																																	
17	1		1	1																																	
17	1		1	1																																	
17	1		1	1																																	
17	1		1	1																																	
17	1		1	1																																	
17	0			1																																	
17	0			1																																	
19	1		1	1																																	
19	1		1	1																																	
19	1		1	1																																	
19	0		1	1																																	
19	0		0	0																																	
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
21	1		1																																		
23	1		1	1																																	
25	1		1	1																																	
25	1		1	1																																	
25	1		1	1																																	
25	1		1	1																																	
25	1		1	1																																	
25	1			1																																	
25	1			1																																	
25	1																																				
25	1																																				
25	1																																				
27	1		1	1																																	
27	1		1	1																																	
27	1		1																																		
27	1		1																																		
27	1																																				
27	1																																				
27	1																																				
29	1		1	1																																	
29	1		1	1																																	
29	1			1																																	
29	1			1																																	
29	1			1																																	
29	1			1																																	
29	1																																				
31	1		1	1																																	
31	1		1	1																																	
31	1		1																																		
31	1																																				
31	1																																				
5			0																																		
5			0																																		
9			0																																		
9			0																																		
9			0																																		
9			0																																		
9			0																																		
9			0																																		
9			0																																		
9			0																																		
13			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
21			1																																		
21			0																																		
23			1	1																																	
23			1	1																																	
15				0																																	
15				0																																	
17				1																																	
17				1																																	
17				1																																	
17				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
21				1																																	
23				1																																	
23				1																																	
																																					
Fig. 2B																																					
Wild-type	W1044X	S1444R	_agl-1 Ê																																		
268	9	24	107																																		
298	98	54	94																																		
258	58	112	71																																		
237	46	23	31																																		
275	72	27	53																																		
303	82	13	63																																		
274	86	20	139																																		
288	27	34	70																																		
310	102	14	97																																		
278	100	17	70																																		
290	178	14	84																																		
263	126	31	120																																		
315	135	35	74																																		
189	58	23	71																																		
301	111	15	49																																		
296	82	108	63																																		
263	46	30	93																																		
298	85	34	114																																		
279	84	31	59																																		
303	78	93	93																																		
299	114	71	66																																		
278	82	47	59																																		
281	85	63	78																																		
318	69	57	77																																		
302	107	48	62																																		
	69	69	104																																		
	69	65	72																																		
	78	96																																			
	83	36																																			
		72																																			
																																					
Fig. 2C																																					
	L1	L2	L3	L4	Adult																																
Wild-type	0	0	0	1	0	0	49.7	45.6	47.2	48.8	54	52.6	0.5	0.5	0.2																						
W1044X	0	2.9	4.3	15.8	17.1	16.2	31.4	41	43.6	50.7	39.1	35.9	2	0	0																						
S1444R	0	0	0	16.4	24.8	21.8	30.2	45.8	48.1	53.2	29.5	30.1	0.2	0	0																						
_agl-1 Ê	0.87	6.9	8.3	22.2	26.1	23.2	42.9	32.7	41.9	34	34.3	26.6	0	0	0																						
																																					
Fig. 2D																																					
	Time (min)	Wild-type	agl-1 (W1044X)	agl-1(S1444R)	agl-1(knu867)																																
	30	408	468	454	428	384	417	408	388	416	339	340	348	348	392	316	368	360	380	266	234	230	280	240	258	412	354	294	376	414	347	398	374	329	405	438	529
	60	382	447	416	419	404	362	440	370	360	400	366	368	399	392	356	376	395	390	262	229	236	274	240	224	378	282	259	414	420	369	425	451	410	458	414	498
	90	411	397	386	413	408	445	424	421	376	432	415	420	404	414	380	408	388	425	276	249	318	264	266	224	375	265	262	404	383	385	402	448	442	458	460	532
	120	410	434	424	406	394	432	430	446	396	408	425	410	362	442	352	435	406	428	328	252	318	310	267	266	384	335	346	432	435	392	422	434	398	458	450	527
	150	400	415	444	396	404	391	469	432	399	408	398	408	369	410	347	396	376	408	303	302	261	274	193	230	401	301	328	376	374	386	430	386	352	464	416	516
	180	372	422	436	396	390	422	412	398	380	414	366	402	389	438	346	386	424	412	300	240	238	231	212	212	381	302	322	438	329	388	378	364	346	470	380	464
	210	396	392	411	396	414	420	377	400	330	432	355	380	359	420	357	411	386	426	305	250	245	272	178	217	373	270	316	370	360	375	402	372	382	436	402	500
	240	420	428	412	338	373	420	359	383	412	320	429	426	348	433	326	412	413	407	275	249	253	279	158	236	352	276	336	391	394	358	396	394	386	418	422	463
	270	392	412	410	360	408	374	346	364	402	360	368	432	354	400	314	397	412	364	334	282	243	288	192	248	348	307	330	404	448	406	417	422	434	410	416	466
	300	385	416	368	384	390	334	416	350	366	378	434	390	353	422	347	407	369	368	281	248	256	308	172	258	361	326	358	373	418	389	424	416	378	433	386	437
	330	364	364	403	336	384	335	384	326	367	358	372	404	326	368	362	368	360	368	270	266	240	292	260	252	382	329	306	404	419	366	384	394	368	432	396	371
	360	406	406	410	358	376	370	378	379	417	385	346	360	327	352	325	400	358	362	260	305	252	282	248	293	396	308	340	412	458	420	418	423	374	437	366	422
	390	387	422	398	365	376	364	303	342	376	357	402	374	362	340	360	368	379	396	273	282	268	269	256	242	396	298	324	430	414	399	414	422	424	438	363	475
	420	383	408	410	351	372	318	323	360	358	344	346	376	348	368	326	406	366	396	252	236	218	246	228	228	390	282	352	394	382	368	386	415	355	442	386	412
	450	395	378	386	348	359	334	364	308	381	336	360	344	309	370	358	336	354	381	222	226	256	234	194	250	338	307	284	353	414	398	344	391	380	430	334	366
	480	400	386	389	330	310	324	324	330	336	336	371	344	306	318	318	378	348	339	238	244	208	235	220	223	301	293	278	424	360	412	356	374	358	422	360	355
	510	414	367	359	296	390	310	342	302	324	347	378	338	320	320	276	328	326	342	262	231	196	240	225	290	308	262	264	356	346	410	368	391	308	379	380	330
	540	388	416	366	307	368	244	338	354	325	370	291	326	326	309	314	365	324	328	255	261	198	241	193	266	332	251	323	362	338	388	366	385	344	312	360	362
	570	389	376	364	316	330	300	319	335	357	333	348	329	289	280	279	312	304	334	291	230	214	222	180	226	286	296	294	360	323	354	338	356	300	328	310	302
	600	384	381	367	332	341	290	350	300	346	316	308	302	298	320	298	320	338	327	274	252	219	236	172	226	260	292	270	356	358	329	278	336	322	296	278	292
																																					
Fig. 2EÊ																																					
	Days of adulthood	N2	agl-1(S1444R)	agl-1(W1044X)	agl-1(deletion)																																
	4	0	0																																		
	4	0	0																																		
	4	0	0																																		
	4	0	0																																		
	4	0	0																																		
	4	0	0																																		
	4	0	0																																		
	4	0	0																																		
	5	0	0																																		
	5	0	0																																		
	5	0	0																																		
	6	0																																			
	8	0																																			
	8	0																																			
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	0																																		
	9	1	1																																		
	9	1	1																																		
	9	1	1																																		
	9	1	1																																		
	9	1	1																																		
	9	1	1																																		
	10	0	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	11	1	0																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	1	1																																		
	11	0	1																																		
	12	1	0																																		
	12	1	1																																		
	12	1	1																																		
	12	1	1																																		
	12	1	1																																		
	12	1	0																																		
	12	1	0																																		
	12	1	0																																		
	12	1	0																																		
	12	1	0																																		
	12	1	0																																		
	12	1	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	4	0	0																																		
	4	0																																			
	4	0																																			
	7	1	1																																		
	7	1	0																																		
	7	1	0																																		
	7	0	0																																		
	7	0	0																																		
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	9	1																																			
	9	0																																			
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	1	1																																		
	10	0	1																																		
	10	0	1																																		
	10	0	1																																		
	10	0	1																																		
	10	0	1																																		
	10	0																																			
	11	1	0																																		
	11	1	0																																		
	11	1	0																																		
	11	1	0																																		
	12	1																																			
	12	1																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	3	0																																			
	3	0																																			
	3	0																																			
	3	0																																			
	3	0																																			
	3	0																																			
	6	1																																			
	7	1																																			
	7	1																																			
	8	0	0																																		
	8	0	0																																		
	8	0	0																																		
	8	0	1																																		
	8	1	1																																		
	8	1	1																																		
	8	1	1																																		
	8	1	1																																		
	8	1	1																																		
	8	1																																			
	9	1	0																																		
	9	1	0																																		
	9	1	1																																		
	9	1	1																																		
	9	1	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	9	0	1																																		
	10	0	1																																		
	10	0	0																																		
	10	1																																			
	10	1																																			
	10	1																																			
	10	1																																			
	10	1																																			
	10	1																																			
	11	1																																			
	11	1																																			
	12	1	0																																		
	12	0	0																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	1																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0	0																																		
	12	0																																			
	6	1	1																																		
	6	1	1																																		
	6	1	1																																		
	6	0	1																																		
	6	0	0																																		
	6	0	0																																		
	6	0	0																																		
	6	0	0																																		
	6	0																																			
	6	0																																			
	6	0																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		0																																		
	7		0																																		
	7		0																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	11		0																																		
	11		0																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	5		0																																		
	5		0																																		
	5		0																																		
	5		0																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		0																																		
	7		0																																		
	7		0																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	3																																				
	3																																				
	3																																				
	3																																				
	3																																				
	3																																				
	3																																				
	7																																				
	7																																				
	7																																				
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	4			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			1																																	
	6			1																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			0																																	
	8			0																																	
	8			0																																	
	8			0																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			1																																	
	9			1																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	9			0																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			0																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
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	12			0																																	
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	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
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	12			0																																	
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	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
	12			0																																	
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	12			0																																	
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	12			0																																	
	12			0																																	
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	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	3				0																																
	3				0																																
	3				0																																
	3				0																																
	3				0																																
	3				0																																
	3				0																																
	4				0																																
	4				0																																
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	4				0																																
	4				0																																
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	4				0																																
	4				0																																
	4				0																																
	4				0																																
	4				0																																
	4				0																																
	4				0																																
	4				1																																
	4				1																																
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	4				0																																
	6				1																																
	6				1																																
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	6				0																																
	6				0																																
	6				0																																
	6				0																																
	6				0																																
	6				0																																
	6				1																																
	6				1																																
	6				1																																
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	6				0																																
	6				0																																
	6				0																																
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	6				0																																
	6				0																																
	6				0																																
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	6				0																																
	6				0																																
	6				0																																
	6				0																																
	6				0																																
	6				0																																
	6				0																																
	6				0																																
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	8				1																																
	8				1																																
	8				1																																
	8				1																																
	8				1																																
	8				1																																
	8				0																																
	8				0																																
	8				0																																
	8				0																																
	8				1																																
	8				1																																
	8				1																																
	8				0																																
	8				0																																
	9				1																																
	9				1																																
	9				1																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				1																																
	9				1																																
	9				1																																
	9				1																																
	9				1																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	10				1																																
	10				1																																
	10				1																																
	10				1																																
	10				1																																
	10				1																																
	10				1																																
	10				1																																
	10				1																																
	10				1																																
	10				0																																
	10				0																																
	10				0																																
	10				0																																
	10				0																																
	10				1																																
	10				1																																
	10				1																																
	10				0																																
	10				0																																
	10				0																																
	10				0																																
	10				0																																
	10				0																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				0																																
	11				1																																
	11				0																																
	11				0																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			0	1																																
	12			1	1																																
	12			1	1																																
	12			1	1																																
	12			1	1																																
	12			1	1																																
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
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	12				0																																
	12				0																																
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	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
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	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
																																					
Figure 3: Code provided in the Supplementary data																																					
																																					
Figure 4																																					
Fig. 4B																																					
	DMSO	Pimozide	Clopidol	Pramoxine HCl	Tetraethylhiuram Disulfide	Geneticin	Amphotericin B	Domperidone																													
	140.280537	82.8461748	82.9371205	101.281472	83.3295904	150.976962	128.896799	103.141448																													
	126.117929	82.8757438	42.881201	92.0791259	90.4395345	186.240421	93.4765857	108.715779																													
	59.8555884	81.1554668	41.6365568	47.8513602	74.9019959	124.123165	104.365323	102.627323																													
	73.7459454	59.2507207		103.586689	81.4320299	168.032238	79.7817826	111.303593																													
	57.9092339	63.2899867	126.319496	82.1463716	123.930265	145.705242	148.508071	74.1564577																													
	68.4970294	79.2097565	92.6542444	49.5761797	60.5744358	179.21265	129.051609	96.7094719																													
	114.908851	61.8958753	105.503429	57.6343081	36.8295762	81.1711647	131.730783	66.2375794																													
	158.684885	33.2558896	99.1477523	25.8583764	25.5255147	111.933831		105.86953																													
	111.142459	45.3967495	136.932036	28.7545301	68.8880984	130.356718	115.277623	79.8999486																													
	96.2123197	46.98829	152.655586	42.1291466	78.0996788	107.651823	71.1730412	90.2998868																													
	91.6275075	64.6057688	113.149862	64.3051929	42.3293717		114.965082																														
	95.8747818	35.0712159	92.3856621			74.9872947	60.8914299	132.169242																													
	105.142932			93.3087922	90.6781172	45.9207684	87.8408499	130.430959																													
	71.687754	92.4779271		63.7217794	105.887306	55.7071405	84.50978	122.131543																													
	113.452986	73.7996567		52.1479273	93.6802017	33.6653597		138.510763																													
	97.6505481	79.8998552		117.199096	108.525713			50.5372729																													
	110.360747	76.5557947		108.550805	81.2334961			88.6498341																													
	106.847965	106.883216		96.4493047				86.3702761																													
	95.8599901	97.0328581																																			
	73.7406865																																				
	166.00092																																				
	64.3984029																																				
	126.334024																																				
	66.3103113																																				
	92.5355368																																				
	113.218399																																				
	101.601729																																				
																																					
	139.514309																																				
	108.035751																																				
	86.7543658																																				
	88.6024729																																				
	77.0931011																																				
	117.967512																																				
	82.4556895																																				
	119.860752																																				
	81.000228																																				
	86.8430987																																				
	107.491104																																				
	104.381616																																				
	58.6627681																																				
	102.829068																																				
	108.434851																																				
	111.237425																																				
	118.835888																																				
	90.7254381																																				
	90.1986736																																				
	81.4776729																																				
	137.598215																																				
	122.721736																																				
	102.310493																																				
	136.13438																																				
	78.6423106																																				
	120.619454																																				
	63.3276299																																				
	76.2439965																																				
	114.875595																																				
	123.276675																																				
	109.812343																																				
	99.9071373																																				
	52.1282494																																				
	126.401579																																				
	90.981938																																				
	84.6143532																																				
	134.131035																																				
	92.6190975																																				
	71.251997																																				
	130.7479																																				
	137.267252																																				
	108.172172																																				
	80.227476																																				
	74.7964649																																				
	68.7887341																																				
	86.9518565																																				
	122.069271																																				
	114.646634																																				
	73.8344012																																				
	102.497838																																				
	109.945044																																				
	127.148439																																				
	86.0124482																																				
	76.8940692																																				
	130.192186																																				
	119.580912																																				
	98.6687665																																				
	76.0381628																																				
	75.5199731																																				
	79.8740417																																				
	102.838598																																				
	123.450585																																				
	103.289061																																				
	90.5477154																																				
	148.860521																																				
	91.3943283																																				
	59.7451505																																				
																																					
	118.339766	94.3822813	126.4896	93.8737985	78.8479447	120.451337	65.4659647	121.007801																													
	118.160812	78.9218496	101.329886	106.276982	87.7201242	110.383432	68.471733	93.1073669																													
	99.9268914	51.3275349	68.0686697	107.242491	33.8424788	142.165706	78.660051	113.954839																													
	87.6491282	84.6088392	95.8193127	121.94707	90.2897201	129.334129	63.3918051	143.259852																													
	109.24595	59.5797728	91.8894283	61.3351576	146.615035	121.762466	93.0387504	59.5444503																													
	104.68382	52.6057775	71.7589844	93.4251393	135.262796	83.2994091	52.620925	117.955115																													
	102.426805	84.3823181	90.997796	111.468623	151.4877	66.081842	63.9902808	93.7864054																													
	71.4952718	39.3198241	79.1227639		98.1535187	64.9674849																															
	120.622168	65.8091411	74.3713766																																		
	67.4493871		66.9847228																																		
	137.139493		84.020058																																		
	79.1981181																																				
	42.4539049																																				
	107.236725																																				
	99.8838139																																				
	92.879461																																				
	66.9156671																																				
	85.3452394																																				
	147.739094																																				
	125.841336																																				
	113.616797																																				
	124.517572																																				
	36.0242954																																				
	103.033702																																				
	95.7587848																																				
	101.207513																																				
	127.343491																																				
	125.060589																																				
	83.1093561																																				
	64.4865643																																				
	99.6037966																																				
	148.114592																																				
	52.281611																																				
	136.019979																																				
	158.902114																																				
	57.2379363																																				
	47.8399708																																				
	46.5604214																																				
	106.224784																																				
	124.998575																																				
	122.216219																																				
	111.210833																																				
	67.4868758																																				
	121.302292																																				
	141.140371																																				
	117.945499																																				
	74.7020134																																				
	66.2121158																																				
	121.812063																																				
	85.2352918																																				
	77.7794778																																				
	115.173168																																				
	103.242428																																				
	94.6715273																																				
	102.086045																																				
																																					
Figure 5																																					
Fig. 5B																																					
	CTRLÊ	gpa-15	erm-1	ant-1.1	chk-1	CTRL 2	tax-6	let-607	pkc-1	CTRL 3	CYP-13A6	CYP-13A5	CTRL 4	jmjd-1.2	CTRL 5	CYP-13B2	gnrr-1	ugt-23	OP501.4	cat-2	CYP-33C3																
	114.933638	111.351761	34.8688275	57.4005308	57.9729488	65.1336958	82.0919622	47.4617504	101.616881	140.992402	146.791049		125.429921	70.2164637	142.678282	207.926294	49.47921	183.98591																			
	85.0663623	73.6505703	39.0723907	70.1916642	80.999842	49.7759868	65.9418425	28.426102	92.1651899	137.234137	160.243812	169.822002	147.259843	50.1835779	149.705968	165.67229	77.8925079	150.420699																			
	79.3804953	81.0942944	33.0055063	72.5436433	75.8591792	53.6259818	64.7661256	23.2353329	69.3502972	64.3875289	150.160162	198.605952	68.9205531	78.0635705	66.2814725	186.090387	77.26885	125.931225																			
	101.358382	57.9576203	72.7901028	73.9373308	32.6305037	116.725193	24.5918476	11.0919599	94.0369715	85.0053112	184.600435	201.755272	115.028066	49.9498919	95.6236753	141.832277	78.6934682	132.715088																			
	119.261122	49.1299143	78.3860326	72.5493422	69.2900137	137.568959	32.5245603	51.9579491	33.8333061	93.3568376	140.790498	207.095825	114.202251	55.2134079	73.8192992	199.580698	70.1181548	132.812379																			
	102.672003	66.2133807	98.0697983	66.4259199	64.2671949	177.170184	43.7688681		35.9263613	91.1384391	135.968842	183.325277	87.4908615		159.137741	118.72742		150.614778																			
	98.0144693	55.7131906	57.0598923	54.1682034	43.2259053	131.190038	65.1459863		27.7688535	78.7517859	96.1144498	132.246354	93.3385237		99.73478	175.147749		113.549778																			
	99.3135272	62.3585096	22.5557803			67.686042	62.7503681		18.594668	109.133558	149.885483		75.7556798		70.4548868	172.97323		152.61092																			
	97.7374164	85.6405591	30.6711344			60.6082169			17.2292571	102.755188			72.5743016		75.6108287	126.306659		162.089407																			
	100.826336					173.598884			68.3801985	111.491696			94.3402027		66.9530658	137.662925		147.112304																			
	101.436248					66.9168196			95.3623639	72.5065765			95.5846465		126.51983			122.644469																			
	92.5380241					81.5428769				67.580223			115.463654		140.536263			125.214963																			
	119.286999					92.5605384				100.489715			105.724607		106.780244																						
	84.1091696					108.574885				145.176602			111.792536		68.147371																						
	104.065807					117.3217				126.159775			110.203472		79.2496544																						
	111.748769					118.290997				83.3202554			59.7948302		78.7666377																						
	105.096133					97.0039149				128.129028			107.096052		123.622708																						
	83.155098					84.7050878				62.9870619			98.016143		79.9489115																						
	81.3779164					102.283952				122.666996			86.0007461		55.8892922																						
	72.6887796					111.220129				76.7368836			122.947417		54.1352821																						
	145.933304					86.4959188				152.239309			85.5466595		114.481644																						
	85.7942688					72.9212191				90.9733172			97.5289256		61.5718438																						
	90.4133125					75.8035603				79.4399941			101.317426		160.556416																						
	96.8421045					145.068891				77.3473793			104.09836		99.5435489																						
	126.950314					106.20633				129.176478			111.4616		97.8768078																						
	124.442721					101.379771				141.536626			120.849715		115.580058																						
	72.2053041					98.620229				100.939361			72.2330077		136.793487																						
	103.351975					60.418564				68.7248322			117.675011		98.0649812																						
	123.799046					88.258228				93.6566549			104.70442		155.95888																						
	76.2009535					156.597952				65.9660483			105.224984		199.461033																						
	85.8433494					94.7252562				56.3956444			91.807577		138.619869																						
	96.9604389					126.307211				70.617213			80.5880083		74.8606333																						
	117.196212					83.9757234				65.4943851			89.5914915		45.049277																						
	85.0822518					84.5760956				92.9515553			94.4168105		64.656409																						
	96.5139024					89.2989422				154.905258			111.661913		105.308281																						
	89.9728428					115.842028				159.635944			103.568462		121.931684																						
	116.683914					89.1183046				111.29808			100.761323		64.9592678																						
	111.747089					120.608084				106.52818			91.269059		85.6357408																						
	119.534251					90.2736115				103.20086			117.728875		48.949477																						
	81.2372451					140.817993				78.9728802			99.1791152		71.1153086																						
	99.2285044					84.6448615				109.670068			94.9655424		125.429158																						
	103.70163					74.5371454				102.104143			85.1678312		201.160209																						
	109.066406					104.102735				124.363485			111.689577		109.982316																						
	92.6462592					45.8349565				63.862304			96.6247423		91.6351402																						
	94.5857053					126.184698				74.3756014			97.9011551		86.5920498																						
	95.29808					123.877611				79.2879628			115.954372		65.3960402																						
	100.644224					64.5859304				118.093851			120.717456		104.531887																						
	118.741065					90.6397943				95.529839			68.8022742		94.9530932																						
	85.3166307					111.545329				111.256077			110.183712		33.5873297																						
	129.016646					111.627113				100.266811			101.764742		112.161934																						
	105.910253					94.0393516				121.189858			105.622787		82.9952824																						
	101.444912					127.562482				111.924708			83.3145567		130.8624																						
	80.7199591					93.5342606				94.4600538			86.5675424		111.749949																						
	82.9082298					121.210736				116.829783			112.54666		95.2751768																						
						69.8477867				76.7854549			91.3638799		131.736319																						
	65.1336958					49.9303863				103.431792			100.104803		78.3677982																						
	49.7759868					218.359664				111.847959			57.8633865		69.0130743																						
	53.6259818					79.1870839				88.7897347			71.3048302		151.763464																						
	116.725193					67.9300827				125.064302			106.696898		100.786474																						
	137.568959					160.280205				67.4574003			142.813114		67.8432282																						
	177.170184					99.46795				103.408812			129.853088		72.7233269																						
	131.190038					70.3713179				130.125552			113.878561		75.8723872																						
	67.686042					40.4206673				89.9645925			89.9645018		131.011121																						
	60.6082169					97.839549				101.872216			104.808563		123.45391																						
	173.598884					59.7342813				113.572694			150.029054		95.3260978																						
	66.9168196					140.400488				90.6460512			103.948594		98.6896554																						
	81.5428769					131.485542				94.5493472			37.3707262		147.770584																						
	92.5605384					89.6458106				79.2695477					59.5543149																						
	108.574885					86.212784				119.875334					135.446981																						
	117.3217					130.855855				164.853957					68.1143486																						
	118.290997					116.830731				89.9201199					71.6441093																						
	97.0039149					76.4548199				77.6702203					165.895018																						
	84.7050878					177.021426				97.5177775					152.805566																						
	102.283952					189.894567				64.5404758					42.364799																						
	111.220129					59.5532791				113.471473					82.6804334																						
	86.4959188					76.3115462				72.150643					59.3273497																						
	72.9212191					58.1373949				120.277604					96.9268335																						
	75.8035603					39.0817869				194.516075					103.821857																						
	145.068891									102.065539					65.3315441																						
	106.20633									113.703562					52.102491																						
	101.379771									78.9839762					133.847018																						
	98.620229									102.954757					157.773547																						
	60.418564									43.8427615					90.4186866																						
	88.258228									82.5733643					85.4100478																						
	156.597952									101.458736					73.1463558																						
	94.7252562									59.6236256					70.7939277																						
	126.307211									103.892427					132.378931																						
	83.9757234									116.660852					117.093181																						
	84.5760956									105.653638					117.882412																						
	89.2989422									104.560959																											
	115.842028									83.5076192																											
	89.1183046									77.7984006																											
	120.608084									84.5972963																											
	90.2736115									123.328809																											
	140.817993																																				
	84.6448615																																				
	74.5371454																																				
	104.102735																																				
	45.8349565																																				
	126.184698																																				
	123.877611																																				
	64.5859304																																				
	90.6397943																																				
	111.545329																																				
	111.627113																																				
	94.0393516																																				
	127.562482																																				
	93.5342606																																				
	121.210736																																				
	69.8477867																																				
	49.9303863																																				
	218.359664																																				
	79.1870839																																				
	67.9300827																																				
	160.280205																																				
	99.46795																																				
	70.3713179																																				
	40.4206673																																				
	97.839549																																				
	59.7342813																																				
	140.400488																																				
	131.485542																																				
	89.6458106																																				
	86.212784																																				
	130.855855																																				
	116.830731																																				
	76.4548199																																				
	177.021426																																				
	189.894567																																				
	59.5532791																																				
	76.3115462																																				
	58.1373949																																				
	39.0817869																																				
																																					
	140.992402																																				
	137.234137																																				
	64.3875289																																				
	85.0053112																																				
	93.3568376																																				
	91.1384391																																				
	78.7517859																																				
	109.133558																																				
	102.755188																																				
	111.491696																																				
	72.5065765																																				
	67.580223																																				
	100.489715																																				
	145.176602																																				
	126.159775																																				
	83.3202554																																				
	128.129028																																				
	62.9870619																																				
	122.666996																																				
	76.7368836																																				
	152.239309																																				
	90.9733172																																				
	79.4399941																																				
	77.3473793																																				
	129.176478																																				
	141.536626																																				
	100.939361																																				
	68.7248322																																				
	93.6566549																																				
	65.9660483																																				
	56.3956444																																				
	70.617213																																				
	65.4943851																																				
	92.9515553																																				
	154.905258																																				
	159.635944																																				
	111.29808																																				
	106.52818																																				
	103.20086																																				
	78.9728802																																				
	109.670068																																				
	102.104143																																				
	124.363485																																				
	63.862304																																				
	74.3756014																																				
	79.2879628																																				
	118.093851																																				
	95.529839																																				
	111.256077																																				
	100.266811																																				
	121.189858																																				
	111.924708																																				
	94.4600538																																				
	116.829783																																				
	76.7854549																																				
	103.431792																																				
	111.847959																																				
	88.7897347																																				
	125.064302																																				
	67.4574003																																				
	103.408812																																				
	130.125552																																				
	89.9645925																																				
	101.872216																																				
	113.572694																																				
	90.6460512																																				
	94.5493472																																				
	79.2695477																																				
	119.875334																																				
	164.853957																																				
	89.9201199																																				
	77.6702203																																				
	97.5177775																																				
	64.5404758																																				
	113.471473																																				
	72.150643																																				
	120.277604																																				
	194.516075																																				
	102.065539																																				
	113.703562																																				
	78.9839762																																				
	102.954757																																				
	43.8427615																																				
	82.5733643																																				
	101.458736																																				
	59.6236256																																				
	103.892427																																				
	116.660852																																				
	105.653638																																				
	104.560959																																				
	83.5076192																																				
	77.7984006																																				
	84.5972963																																				
	123.328809																																				
																																					
	125.429921																																				
	147.259843																																				
	68.9205531																																				
	115.028066																																				
	114.202251																																				
	87.4908615																																				
	93.3385237																																				
	75.7556798																																				
	72.5743016																																				
	94.3402027																																				
	95.5846465																																				
	115.463654																																				
	105.724607																																				
	111.792536																																				
	110.203472																																				
	59.7948302																																				
	107.096052																																				
	98.016143																																				
	86.0007461																																				
	122.947417																																				
	85.5466595																																				
	97.5289256																																				
	101.317426																																				
	104.09836																																				
	111.4616																																				
	120.849715																																				
	72.2330077																																				
	117.675011																																				
	104.70442																																				
	105.224984																																				
	91.807577																																				
	80.5880083																																				
	89.5914915																																				
	94.4168105																																				
	111.661913																																				
	103.568462																																				
	100.761323																																				
	91.269059																																				
	117.728875																																				
	99.1791152																																				
	94.9655424																																				
	85.1678312																																				
	111.689577																																				
	96.6247423																																				
	97.9011551																																				
	115.954372																																				
	120.717456																																				
	68.8022742																																				
	110.183712																																				
	101.764742																																				
	105.622787																																				
	83.3145567																																				
	86.5675424																																				
	112.54666																																				
	91.3638799																																				
	100.104803																																				
	57.8633865																																				
	71.3048302																																				
	106.696898																																				
	142.813114																																				
	129.853088																																				
	113.878561																																				
	89.9645018																																				
	104.808563																																				
	150.029054																																				
	103.948594																																				
	37.3707262																																				
																																					
	142.678282																																				
	149.705968																																				
	66.2814725																																				
	95.6236753																																				
	73.8192992																																				
	159.137741																																				
	99.73478																																				
	70.4548868																																				
	75.6108287																																				
	66.9530658																																				
	126.51983																																				
	140.536263																																				
	106.780244																																				
	68.147371																																				
	79.2496544																																				
	78.7666377																																				
	123.622708																																				
	79.9489115																																				
	55.8892922																																				
	54.1352821																																				
	114.481644																																				
	61.5718438																																				
	160.556416																																				
	99.5435489																																				
	97.8768078																																				
	115.580058																																				
	136.793487																																				
	98.0649812																																				
	155.95888																																				
	199.461033																																				
	138.619869																																				
	74.8606333																																				
	45.049277																																				
	64.656409																																				
	105.308281																																				
	121.931684																																				
	64.9592678																																				
	85.6357408																																				
	48.949477																																				
	71.1153086																																				
	125.429158																																				
	201.160209																																				
	109.982316																																				
	91.6351402																																				
	86.5920498																																				
	65.3960402																																				
	104.531887																																				
	94.9530932																																				
	33.5873297																																				
	112.161934																																				
	82.9952824																																				
	130.8624																																				
	111.749949																																				
	95.2751768																																				
	131.736319																																				
	78.3677982																																				
	69.0130743																																				
	151.763464																																				
	100.786474																																				
	67.8432282																																				
	72.7233269																																				
	75.8723872																																				
	131.011121																																				
	123.45391																																				
	95.3260978																																				
	98.6896554																																				
	147.770584																																				
	59.5543149																																				
	135.446981																																				
	68.1143486																																				
	71.6441093																																				
	165.895018																																				
	152.805566																																				
	42.364799																																				
	82.6804334																																				
	59.3273497																																				
	96.9268335																																				
	103.821857																																				
	65.3315441																																				
	52.102491																																				
	133.847018																																				
	157.773547																																				
	90.4186866																																				
	85.4100478																																				
	73.1463558																																				
	70.7939277																																				
	132.378931																																				
	117.093181																																				
	117.882412																																				
																																					
Figure 6																																					
Fig. 6A																																					
	S1444R EV	S1444R chk-1	Wild-type EV	Wild-type chk-1																																	
	85.8433494	57.9729488	117.072593	79.2677385																																	
	96.9604389	80.999842	94.2681483	75.8897345																																	
	117.196212	75.8591792	93.8307981	125.348539																																	
	142.504416	32.6305037	107.996511	70.6131362																																	
	59.6058749	69.2900137	112.474022	89.6001285																																	
	125.879352	64.2671949	68.5330177	74.1419076																																	
	96.6347583	43.2259053	97.0460336	68.1546235																																	
	76.494965	86.3804902	108.778876	59.5554361																																	
	79.8904358	60.4115993																																			
	84.1782364		100.813169	113.061518																																	
	107.835437	124.828096	118.291924	129.004504																																	
	126.976525	66.5089316	118.781111	78.5658652																																	
		50.8025994	124.940244	134.902077																																	
	123.922835	95.6551852	81.0798945	115.97546																																	
	105.753383	64.9985013	68.3650186	66.6537752																																	
	63.218065	51.9266851	144.423117	166.281212																																	
	106.118402		124.789252	75.1026127																																	
	97.7637137	92.2155119	69.4152448	154.132272																																	
	96.6363979	117.470865	56.0932122	105.30672																																	
	101.543948	71.6843171	93.0078125																																		
	105.043256	112.843317																																			
		88.0274986																																			
		46.8903411																																			
		128.289031																																			
		85.0740807																																			
		87.9282841																																			
		42.4616423																																			
		99.1172657																																			
		83.5903989																																			
																																					
Fig. 6B																																					
	S1444R EV	S1444R chk-1	Wild-type EV	Wild-type chk-1																																	
	85.8433494	57.9729488	117.072593	79.2677385																																	
	96.9604389	80.999842	94.2681483	75.8897345																																	
	117.196212	75.8591792	93.8307981	125.348539																																	
	142.504416	32.6305037	107.996511	70.6131362																																	
	59.6058749	69.2900137	112.474022	89.6001285																																	
	125.879352	64.2671949	68.5330177	74.1419076																																	
	96.6347583	43.2259053	97.0460336	68.1546235																																	
	76.494965	86.3804902	108.778876	59.5554361																																	
	79.8904358	60.4115993																																			
	84.1782364		100.813169	113.061518																																	
	107.835437	124.828096	118.291924	129.004504																																	
	126.976525	66.5089316	118.781111	78.5658652																																	
		50.8025994	124.940244	134.902077																																	
	123.922835	95.6551852	81.0798945	115.97546																																	
	105.753383	64.9985013	68.3650186	66.6537752																																	
	63.218065	51.9266851	144.423117	166.281212																																	
	106.118402		124.789252	75.1026127																																	
	97.7637137	92.2155119	69.4152448	154.132272																																	
	96.6363979	117.470865	56.0932122	105.30672																																	
	101.543948	71.6843171	93.0078125																																		
	105.043256	112.843317																																			
		88.0274986																																			
		46.8903411																																			
		128.289031																																			
		85.0740807																																			
		87.9282841																																			
		42.4616423																																			
		99.1172657																																			
		83.5903989																																			
		60.7743556																																			
		58.0465451																																			
																																					
Fig. 6C																																					
	Wild-type	W1044X	S1444R	_agl-1																																	
	376.0355	514.9349	638.9561	620.2621																																	
	359.5294	552.5201	650.5028	612.3665																																	
	415.3801	452.7965	591.6366	664.6393																																	
																																					
Fig. 6D																																					
	Wild-type	W1044X	S1444R	_agl-1																																	
	3648.428	3770.777	3325.627	3687.587																																	
	3914.607	3595.5	3375.191	3476.102																																	
	3504.221	3720.914	3249.108	3640.967																																	
																																					
Fig. 6E/F																																					
																																					
	Days of adulthood	Wild-type	agl-1(S1444R)	EV	chk-1 KD	pkc-1	pkc-2	B0024.13																													
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	8	1																																			
	8	1																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	10	1																																			
	10	0																																			
	10	0																																			
	10	0																																			
	10	0																																			
	10	0																																			
	10	0																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	0																																			
	11	0																																			
	11	0																																			
	11	0																																			
	11	0																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	6		0	0																																	
	6		0	0																																	
	6		0	0																																	
	6		0	0	0																																
	6		0		0																																
	6		0		0																																
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	8		1																																		
	8		1																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		0																																		
	9		0																																		
	9		0																																		
	10		1																																		
	10		1																																		
	10		0																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		0																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			0																																	
	8			0																																	
	8			0																																	
	8			0																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			0																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			0																																	
	11			1	1																																
	11			1	1																																
	11			1	1																																
	11			1	1																																
	11			1	1																																
	11			1	1																																
	11			1	0																																
	11			1	0																																
	11			1	0																																
	11			1	0																																
	11			1	0																																
	11			1	0																																
	11			1	0																																
	11			1	0																																
	11			1																																	
	11			0																																	
	11			0																																	
	12			0																																	
	12			0																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				1																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	7				0																																
	8				1																																
	8				1																																
	8				1																																
	8				1																																
	8				1																																
	9				1																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	9				0																																
	10				1																																
	10				1																																
	10				0																																
	10				0																																
	10				0																																
	12				1																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12	0	0	0	0																																
	12	0	0	0	0																																
	12	0	0	0	0																																
	12	0	0	0	0																																
	12	0		0	0																																
	12	0		0	0																																
	12	0			0																																
	12	0			0																																
	12	0			0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	3					0																															
	4					1																															
	4					0																															
	4					0																															
	4					0																															
	4					0																															
	4					0																															
	5					1																															
	5					1																															
	5					1																															
	5					0																															
	5					0																															
	5					0																															
	5					0																															
	5					0																															
	5					0																															
	5					0																															
	5					0																															
	6					1																															
	6					1																															
	6					1																															
	6					1																															
	6					1																															
	6					0																															
	6					0																															
	6					0																															
	7					1																															
	7					1																															
	7					0																															
	7					0																															
	8					1																															
	8					1																															
	8					1																															
	8					1																															
	8					1																															
	8					0																															
	8					0																															
	8					0																															
	8					0																															
	9					1																															
	9					1																															
	9					1																															
	9					1																															
	9					1																															
	9					1																															
	9					1																															
	9					0																															
	9					0																															
	9					0																															
	9					0																															
	10					1																															
	10					1																															
	10					1																															
	10					1																															
	11					1																															
	11					1																															
	11					1																															
	11					0																															
	12					1																															
	12					1																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	4						1																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	4						0																														
	5						0																														
	5						0																														
	5						0																														
	5						0																														
	5						0																														
	5						0																														
	5						0																														
	5						0																														
	6						1																														
	6						1																														
	6						0																														
	6						0																														
	6						0																														
	6						0																														
	6						0																														
	7						1																														
	7						0																														
	7						0																														
	8						0																														
	8						0																														
	9						1																														
	9						1																														
	9						1																														
	9						1																														
	9						1																														
	9						1																														
	9						1																														
	9						1																														
	9						1																														
	9						0																														
	9						0																														
	9						0																														
	9						0																														
	9						0																														
	10						1																														
	10						1																														
	10						1																														
	10						0																														
	11						1																														
	11						1																														
	11						1																														
	11						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	2							0																													
	3							1																													
	3							1																													
	3							0																													
	3							0																													
	3							0																													
	4							1																													
	4							1																													
	4							1																													
	4							1																													
	4							0																													
	4							0																													
	4							0																													
	4							0																													
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	7							0																													
	8							1																													
	8							1																													
	8							1																													
	8							1																													
	8							1																													
	8							0																													
	9							1																													
	9							1																													
	9							1																													
	9							0																													
	10							1																													
	10							1																													
	10							1																													
	10							1																													
	10							1																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	11							1																													
	11							1																													
	11							0																													
	11							0																													
	11							0																													
	11							0																													
	11							0																													
	12							1																													
	12							1																													
	12							1																													
	12							1																													
	12							1																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
																																					
Fig. 6G																																					
DMSO	Rabusertib																																				
n=1	n=1																																				
84.1895382	107.72873																																				
126.257012	55.8317963																																				
135.847552	62.2302383																																				
122.432288	86.6774973																																				
63.278273	103.400066																																				
119.569266	80.9613964																																				
115.096523	106.632605																																				
89.7085948	103.155123																																				
104.959306	96.118414																																				
66.5001048	66.19493																																				
83.8409582	89.3408935																																				
88.3205847	90.1383445																																				
	98.5652623																																				
85.9284899	69.1727749																																				
148.336449																																					
59.9801255	155.70886																																				
114.32364	151.983357																																				
149.57977	107.494155																																				
111.795471	52.14255																																				
84.2782539	34.9687808																																				
64.1220198	149.90363																																				
111.574176																																					
119.429868	122.978679																																				
50.6517356	78.6967981																																				
	86.8833012																																				
	83.4974397																																				
94.4363696	131.667077																																				
99.5124175	105.102108																																				
118.564955	46.8224566																																				
127.058353	104.735028																																				
46.6538425	111.359515																																				
83.3093737	74.9107307																																				
147.415122	62.6495611																																				
83.0495673	17.5089131																																				
	12.2112882																																				
105.447646	53.8869194																																				
93.1644869	46.5928871																																				
160.199006	53.9090675																																				
80.5493302	38.7615235																																				
74.6820095																																					
97.5823525																																					
107.40039																																					
102.894206																																					
78.0805733																																					
60.9901989																																					
149.396134																																					
103.677325																																					
100.185682																																					
83.2647903																																					
102.48587																																					
94.9103355																																					
149.230651																																					
107.048171																																					
76.2803046																																					
103.581522																																					
68.9490156																																					
																																					
Fig. 6H																																					
	Days of adulthood	Wild-type	agl-1(S1444R)	DMSO	Pyrazole	Rabusertib (LY2603618)																															
	6	0																																			
	6	0																																			
	6	0																																			
	6	0																																			
	6	0																																			
	6	0																																			
	6	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	8	0																																			
	8	0																																			
	9	0																																			
	9	0																																			
	11	1																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		1																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	7		0																																		
	7		0																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		1																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		1																																		
	10		0																																		
	10		0																																		
	10		0																																		
	10		0																																		
	10		0																																		
	10		0																																		
	10		0																																		
	10		0																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		1																																		
	5		0																																		
	5		0																																		
	5		0																																		
	5		0																																		
	5		0																																		
	5		0																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	9		0																																		
	5			1																																	
	5			1																																	
	5			1																																	
	5			1																																	
	5			1																																	
	5			1																																	
	5			0																																	
	5			0																																	
	6			1																																	
	6			1																																	
	6			1																																	
	6			1																																	
	6			1																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	6			0																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			1																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	7			0																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			0																																	
	8			0																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			1																																	
	8			0																																	
	8			0																																	
	8			0																																	
	8			0																																	
	8			0																																	
	8			0																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			0																																	
	9			0																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
	9			1																																	
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Fig. 6I																																					
	W1044X EV	W1044X aak-2	_agl-1 EV	_agl-1 aak-2	EV	aak-2																															
	89.1504725	89.1044265	96.0716793	143.041295	89.9116057	225.773195																															
	107.683155	72.2463176	119.870352	84.6510219	57.4969813	208.017499																															
	72.2744381	45.6310457	71.1990556	113.858523	180.736396	130.030667																															
	111.541722	41.6893496	73.8746613	150.521616	186.573342	186.344475																															
	109.274936	45.0596718	101.470617	150.987127	58.190229	115.396246																															
	106.398908	60.9863291	124.534115	215.106584	60.1827449	181.858303																															
	103.676367	26.3933322	105.34567	164.605021	83.5639659	195.155657																															
		79.4367789	86.9121808	182.643969	51.5748851	133.680082																															
	65.9945132	69.0450548	161.352132	209.481135	32.1492048	77.0410412																															
	74.7034136	42.3403798	77.5778529	198.358455	199.620645	105.830134																															
	77.0474424	88.846412	81.7916847	260.118334		140.278188																															
	90.0819347	72.8636255		203.669112	44.2174018	184.052687																															
	30.4228664	123.672552	98.6296052		101.870218	127.950093																															
	38.0450013	62.920486	136.383206	67.240652	103.078514																																
	105.082582	70.707529	35.9302938	44.9634982	94.4302712	53.6955406																															
	62.4868055		95.4043738	66.106826	119.805109	133.499509																															
	62.4525797	170.948275	117.300153	43.7439754	136.598486	126.708657																															
	157.998147	115.201183	54.0551753	39.7512602		104.580104																															
	105.9525	172.498921	131.693198	74.5190835	101.65676	100.491911																															
	115.099642	91.4130803	130.603996	49.9448045	73.1471295	112.842515																															
	65.3624085	105.31307		72.535391	114.593851	142.718967																															
	94.577898	52.2462036	94.960306	63.7913542	110.602259	104.822802																															
	70.307223	110.53308	108.373754	55.7622469		124.019436																															
	159.509768	154.061796	138.374523	39.6124171		120.896434																															
	159.574305		105.24207	37.369977		161.652136																															
	237.149027	115.13589	85.6582898	55.0898108																																	
	128.151942	89.4932818	67.391057			60.134325																															
		70.065775		110.449723		49.3292304																															
	29.0542651	78.0785542		100.653806		39.8547166																															
	165.630141	66.2050998		137.17505		47.4834697																															
	108.472147	91.8321567		114.770423		22.5640841																															
	90.694341	47.0816515		150.292927																																	
	106.149106	104.884427		110.701902																																	
		86.1279975		90.188978																																	
				86.1148084																																	
				89.8885989																																	
																																					
Fig. 6J																																					
	S1444R	aak-2																																			
	31.46402	10.04991																																			
	52.83553	38.8085																																			
	48.816	44.49732																																			
																																					
Figure S2																																					
Fig. S2A																																					
	Wild-type	W1044X	S1444R	_agl-1																																	
	335.13	303.83	323.57	312.05																																	
	211.74	332.44	311.35	357.3																																	
	239.14	256.96	342.26	279.79																																	
	212.28	306.58	390.03	299.92																																	
	253.08	262.14	302.55	328.8																																	
	265.35	248.65	366.55	259.38																																	
	233.56	283.07	215.35	219.85																																	
	211.3	268.38	334.83	172.7																																	
	270.94	317.61	403.23	112.26																																	
	324.64	304.97	209.72	263.94																																	
	289.13	328.18	283.24	256.4																																	
	235.78	225.97	284.51	268.2																																	
	307.64	208.29	279.45	298.28																																	
	212.31	304.79	251.49	268.44																																	
	254.29	290.61	322.42	331.94																																	
	180.91	297.9	324.78	243.48																																	
	311.17	314.73	177.29	217.79																																	
	208.17	276.49	286.95	263.95																																	
	181.08	353.91	238.32	306.56																																	
	248.41	278.46	247.23	269.7																																	
	139.38	245.73	232.96	245.87																																	
	234.95	325.87	334.16	284.56																																	
	249.57	191.39	227.74	261.81																																	
	182.2	277.42	242.88	317.56																																	
	216.54	273.96	345.14	336.92																																	
	291.8	286.28	384.06	335.51																																	
	291.79	310.17	256.25	321.6																																	
	319.6	289.7	272.23	265.3																																	
	261.61	356	256.51	296.91																																	
	282.97	275.86	341.47	113.49																																	
	284.55	289.75	321.92	322.27																																	
	261.68	258.84	389.51	210.7																																	
	283.5	190.2	317.31	261.27																																	
	324.62	242.23	361.44	306.65																																	
	250.25	239.27	340.47	379.21																																	
	314.67	300.77	316.6	349.88																																	
	239.98	327.14	365.33	312.8																																	
	270.96	314.21	305.06	271.04																																	
	318.24	316.34	379.63	301.05																																	
	324.56	325.25	394.49	237.31																																	
	327.21	358.87	347.1	330.7																																	
	324.45	350.53	359.46	230.14																																	
	286.29	311.17	311.17	311.17																																	
	330.04	251.9	267.86	184.32																																	
	253.73	216.68	349.26	325.65																																	
	307.64	294.6	400.19	322.04																																	
	297.75	341.29	279.13	338.66																																	
	310.74	373	328.13	350.26																																	
	370.53	346.21	291.86	329.19																																	
	282.1	325.83	337.96	253.64																																	
	268.5	226.56	363.1	316.81																																	
	241.99	289.83	293.58	316.45																																	
	223.99	284.74	265.8	305.81																																	
	270.38	291.43	336.1	333.58																																	
	260.51	310.74	363.82	379.36																																	
	201.29	281.48	326.93	73.34																																	
	303.2	229.47	267.28	299.35																																	
	317.16	303.23	248.67	382.44																																	
	288.29	314.01	397.71	99.57																																	
	188.47	323.71	269.6	293.75																																	
	292.46	320.58	309.35	222.59																																	
	256.11	268	295.28	325.41																																	
	228.34	198.45	179.51	268.1																																	
	313.4	307.06	285.73	224.98																																	
	283.75	354	213.73	288.15																																	
	284.84	345.53	217.34	151.39																																	
	317.31	207.09	316.75	317.53																																	
	268.52	308.92	326	473.29																																	
	329.52	264.93	194.76	340.41																																	
	270.21	331.16	294.79	295.16																																	
	364.51	185.13	287.67	309.71																																	
	307.71	278.66	261.1	203.44																																	
	339.27	251.72	235.69	275.24																																	
	359.53	215.53	151.17	368.66																																	
	293.66	332.32	216.74	270.36																																	
	384.54	217.01	346.14	308.26																																	
	350.87	288.39	291.67	275.9																																	
	363.52	309.04	256.27	318.43																																	
	341.54	299.03	298.97	305.29																																	
	276.31	224.79	322.03	277.91																																	
	281.79	253.2	358.42	258.08																																	
	245.54	330.89	358.48	304.13																																	
	307.16	233.97	307.3	294.01																																	
	328.4	308.36	330.17	281.62																																	
	231.42	288.52	256.37	317.42																																	
	234.27	335.06	246.93	279.12																																	
	208.36	374.74	314.11	300.45																																	
	233.23	238.5	359.95	281.15																																	
	280.87	255.49	331.97	223.99																																	
	277.1	194.17	381.26	315.68																																	
	237.04	351.03	307.97	326.5																																	
	265.79	291.81	392.97	287.04																																	
	280.52	386.07	246.08	205.28																																	
	228.79	261.65	326.49	261.8																																	
	197.96	329.53	342.83	244.63																																	
	288.85	360.96	272	342.82																																	
	302.79	327.04	354.27	339.01																																	
	193.52	360.58	345.83	253.32																																	
	243.23	370.31	239.99	218.35																																	
	300.41	341.19	303.61	198.7																																	
	272.16	289.04	282.97	313.63																																	
	204.74	345.33	311.96	274.99																																	
	192.78	131.28	237.67	209.24																																	
	169.96	349.67	293.52	293.78																																	
	241.21	289.34	291.8	236.5																																	
	341.93	334.68	291.79	249.11																																	
	283.13	330.73	319.6	343.02																																	
	249.63	296.35	261.61	278.91																																	
	241.09	380.8	298.29	308.27																																	
	253.45	356.9	247.37	347.28																																	
	198.92	372.75	181.87	332.87																																	
	218.79	375.01	339.22	230.8																																	
	185.46	333.74	306.96	312.74																																	
	242.99	333.7	309.48	219																																	
	371.02	336.85	322.08	295.44																																	
	281.63	373.37	365.25	269.83																																	
	212.85	347.31	266.09	334.37																																	
	200.85	381.77	302.52	261.61																																	
	157.51	369.69	352.52	282.97																																	
	201.79	337.95	312.35	270.39																																	
	222.31	295.74	319.49	294.52																																	
	278.96	282.97	323.96	299.42																																	
	342.5	343.25	345.17	319.6																																	
	270.41	375.02	268.04	274.44																																	
	320.01	357.92	387.76	348.91																																	
	362.1	345.86	301.04	326.75																																	
	331.42	336.72	372.68	367.31																																	
	324.83	301.55	314.02	120.47																																	
	314.09	381.76	256.16	353.66																																	
	310.67	377.58	341.5	372.07																																	
	309.17	383.48	329.43	387																																	
	280.08	226.69	294.6	363.41																																	
	293.25	195.28	292.97	336.63																																	
	349.74		383.27	344.88																																	
	322.61		340.58	388.29																																	
	348.43		303.14	338.29																																	
	298.72		349.56	298.08																																	
	305.85		226.05	353.43																																	
	319.54		295.86	213.46																																	
	456		351.61	347.91																																	
	328.68		290.67	246.34																																	
	322.62		342.69	351.35																																	
	268.53		375.94	298.58																																	
	317.58		303.6	328.42																																	
	322.48		302.7	335.96																																	
	258.69		336.18	299.44																																	
	298.62		328.57	415.77																																	
	303.96		266.46	257.37																																	
	307.25		348.36	326.28																																	
	278.66		301.3	291.8																																	
	230.66		312.05	291.79																																	
																																					
Fig. S2B																																					
	Wild-type	W1044X	S1444R	_agl-1																																	
	529.1	603.23	646.86	589.32																																	
	409.96	628.87	543.41	608.14																																	
	445.57	579.36	599.51	578.41																																	
	421.42	652.78	617.3	666.72																																	
	434.82	677.69	670.49	364.95																																	
	377.43	562.76	494.67	432.58																																	
	432.79	546.95	714.08	543.54																																	
	492.82	539.92	556.16	548.46																																	
	453.47	657.81	706.3	499.43																																	
	506.12	614.69	458.85	583.48																																	
	518.87	599.23	526.57	492.52																																	
	450.25	587.34	495.53	505.03																																	
	582.96	609.61	457.9	543.24																																	
	414.01	556.48	490.55	583.77																																	
	480.01	581.81	643.79	585.23																																	
	451.95	562.17	529.69	494.74																																	
	576.49	599.14	464.72	472.75																																	
	409.78	600.35	524.93	464.05																																	
	461.97	569.09	482.61	570.37																																	
	436.56	636.08	542.26	526.67																																	
	451.95	653.01	380.55	541.15																																	
	409.44	527.59	557.25	539.52																																	
	484.45	572.14	623.85	544.54																																	
	423.35	627.01	581.46	571.78																																	
	460.12	625.48	475.3	598.2																																	
	506.87	500.21	495.54	584.76																																	
	502.81	631.3	550.8	576.63																																	
	632.15	559.49	533.41	509.21																																	
	526.83	516.17	549.98	478.54																																	
	549.72	513.96	529.68	449																																	
	473.74	654.09	525	570.78																																	
	466.55	633.04	602.59	512.89																																	
	596.53	549.36	518.43	595.9																																	
	506.64	602.14	528.91	598																																	
	591.74	615.68	603.23	654.45																																	
	548.4	640.29	554.17	634.32																																	
	611.23	577.13	414.49	627.3																																	
	474.74	640.36	589.89	601.09																																	
	525.62	546.11	607.84	592.7																																	
	635.18	569.37	599.51	539.47																																	
	611.23	527.98	561.93	645.61																																	
	606.25	584.27	562.19	596.95																																	
	594.46	541.28	545.8	586.43																																	
	596.9	587.38	592.17	588.34																																	
	420.1	605.79	526.3	494.01																																	
	524.94	632.64	541.13	484.55																																	
	516.26	533.47	540.38	507.46																																	
	521.29	609.9	526.08	601.12																																	
	458.96	614.32	498.12	683.64																																	
	440.22	605.56	559.48	627.36																																	
	567.15	605.8	544.34	397.62																																	
	472.33	603.95	533.5	449.35																																	
	501.57	497.07	564.49	486.78																																	
	527.51	563.12	518.6	587																																	
	531.64	621.65	482.29	418.94																																	
	553.16	568.74	501.28	622.62																																	
	555.4	577.13	552.27	639.34																																	
	530.51	507.94	497.46	588.12																																	
	413.26	612.24	533.93	571.19																																	
	416.02	587.4	525.81	551.08																																	
	501.03	657.99	481.81	553.94																																	
	559.41	624.76	447.59	516.42																																	
	483.23	510.43	464	596.74																																	
	510.48	587.7	505.23	673.66																																	
	492.2	532.01	601.9	581.97																																	
	549.46	577.11	592.25	502.96																																	
	521.6	659.44	531.03	522.65																																	
	429.89	699.48	488.54	587.98																																	
	459.88	608.08	517.64	568.74																																	
	490.63	469.52	468.89	669.99																																	
	473.2	589.9	495.1	589.9																																	
	488.74	501.39	448.64	609.63																																	
	551.21	700.24	456.81	502.2																																	
	537.02	572.03	555.95	562.91																																	
	494.99	629.86	494.22	575.26																																	
	442.26	522.21	534	599.53																																	
	508.3	611.9	499.61	608.02																																	
	581.97	587.56	312.55	521																																	
	502.96	453.53	493.16	624.03																																	
	522.65	528.53	515.29	634.93																																	
	587.98	524.18	486.95	536.61																																	
	568.74	565.84	510.43	508.73																																	
	583.09	548.67	503.13	583.26																																	
	536.69	607.65	553.43	634.52																																	
	610.23	671.49	449.02	576.49																																	
	659.59	562.92	528.14	667.59																																	
	597.42	565.65	537.45	607.88																																	
	461.5	533.94	545.93	579.02																																	
	573.89	624.33	481.54	622																																	
	576.87	590.68	517.83	558.5																																	
	573.9	576.72	527.93	557.02																																	
	655.95	556.85	462.55	556.12																																	
	563.51	632.05	539.06	594.16																																	
	634.2	589.59	555.01	572.32																																	
	569.41	502.8	416.63	554.34																																	
	667.62	602.81	504.27	484.77																																	
	620.53	380.21	456.7	498.41																																	
	612.3	528.55	456.02	533.89																																	
	619.73	464.97	503.51	483.34																																	
	537.45	502.44	516.13	461.04																																	
	630.08	438.1	522.76	500.58																																	
	561.53	429.3	536.6	491.09																																	
	597.34	553.31	536.47	513.29																																	
	651.93	615.69	506.7	440.34																																	
	571.23	501.33	447.61	611.12																																	
	570.4	584.44	549.12	482.07																																	
	609.11	608.92	571.98	503.54																																	
	561.06	525.66	518.71	405.92																																	
	560.12	567.43	529.23	534.6																																	
	658.25	588.1	485.06	487																																	
	566.01	575.45	545.44	531.18																																	
	589.49	567.76	493.25	590.18																																	
	617.51	570.85	522.51	506.75																																	
	503.12	490.88	584.48	594.54																																	
	588.62	625.01	489.54	480.77																																	
	622.66	526.84	517.17	517.55																																	
	644.17	547.15	535.75	443.3																																	
	557.33	547.42	443.86	578.28																																	
	610.85	607.55	500.46	490.2																																	
	672.84	602.15	457.36	517.91																																	
	625.49	608.98	550.88	534.79																																	
	577.67	594.41	509.62	512.76																																	
	565.55	515.14	482.76	536.06																																	
	616.64	548.07	540.32	571.04																																	
	631	538.99	565.31	480.83																																	
	653.01	616.78	464.24	516.29																																	
	619.86	583.34	509.97	550.45																																	
	579.21	586.79	624.51	628.63																																	
	485.56	554.75	524.34	565.93																																	
	423.45	608.1	498.93	551.99																																	
	467.15	443.65	470.98	522.42																																	
	530.58	576.49	440.9	355.09																																	
	434.3	557.95	464.67	570.13																																	
	430.1		545.68	575.39																																	
	426.91		475.92	506.52																																	
	463.73		533.39	449.01																																	
	473.67		410.45	561.86																																	
	554.92		557.99	522.01																																	
	547.67		534.9	599.47																																	
	466.34		468.16	568.66																																	
	461.46		518.88	554.63																																	
	441.36		495.35	502.09																																	
	393.18		464.23	492.56																																	
	441.08		481.75	680.2																																	
	431.66		541.5	559.79																																	
	425.56		581.97	565.72																																	
	424.97		502.96	535.52																																	
	477.65		522.65	512.24																																	
	452.56		587.98	480.32																																	
	451.7		568.74	492.23																																	
	401.77		576.49	594.9																																	
																																					
Fig. S2C																																					
	Wild-type	W1044X	S1444R	_agl-1																																	
	42.34	56.22	66.76	52.58																																	
	37.88	51.34	58.06	53.99																																	
	34.3	61.84	72.61	59.08																																	
	37.73	45.37	67.77	62.99																																	
	39.32	62.04	77.96	41.97																																	
	50.56	65.22	69.78	51.2																																	
	35.88	55.88	69.88	67.14																																	
	40.2	46	74.14	40.46																																	
	43.15	53.48	80.27	40.91																																	
	38.6	73.82	57.45	70.23																																	
	39.07	70.26	80.46	48.47																																	
	32.45	51.5	67.91	56.91																																	
	52.54	44.74	66.5	48.91																																	
	32.44	60.15	64.67	65.13																																	
	44.14	44.84	61.27	51.48																																	
	40.89	49.87	67.58	47.35																																	
	47.13	71.32	60.94	48.67																																	
	37.51	61.79	63.54	46.02																																	
	36.7	52.62	84.29	67.08																																	
	47.69	49.41	56.9	53.88																																	
	32.27	57.37	82.88	49.35																																	
	40.96	57.21	80.24	70.96																																	
	37.57	53.23	80.05	67.56																																	
	35.74	61.06	59.4	49.95																																	
	33.79	73.94	53.41	52.29																																	
	38.62	70.8	74.91	56.82																																	
	45.03	56.18	74.05	52.64																																	
	44.22	48.83	57.05	53.35																																	
	35.21	71.19	62.62	47.78																																	
	57.59	39.64	79.17	50.59																																	
	35.21	36.81	57.61	58.48																																	
	37.29	59.13	72.72	66.89																																	
	46.85	67.51	77.09	51.94																																	
	38.38	50.97	69.04	46.05																																	
	27.49	56.48	59.72	57.58																																	
	40.94	59.35	61.36	58.04																																	
	46.72	84.01	50.59	59.22																																	
	48.14	55.33	75.71	62.54																																	
	42.07	50.79	66.42	50.53																																	
	40.61	47.17	61.64	46.22																																	
	47.16	50.44	50.36	59.88																																	
	47.28	50.35	65.1	52.81																																	
	37.17	50.42	73.15	75.63																																	
	39.81	62.46	68.5	74.19																																	
	34.4	51.67	62.44	81.56																																	
	38.17	57.9	63	62.84																																	
	27.18	52.19	62.1	57.11																																	
	38.32	63.71	66.46	45.5																																	
	37.02	51.67	71.71	63.33																																	
	34.95	59.17	68.09	57.66																																	
	38.53	67.66	88.99	42.97																																	
	52.12	87.35	60.06	30.11																																	
	48.93	43.88	68.28	49.21																																	
	33.53	52.19	62.28	47.73																																	
	34.93	45.26	45.92	35.1																																	
	31.23	41.42	52.3	65.06																																	
	28.36	59.12	46.07	32.79																																	
	43.13	49.71	46.3	50.77																																	
	42.76	71.88	45.34	46.17																																	
	44.34	68.99	43.33	41.82																																	
	51.02	55.97	47.26	56.64																																	
	44.62	68.64	53.01	66.56																																	
	39.07	80.84	60.67	44.01																																	
	58.1	60.51	50.54	52.58																																	
	52.09	45.46	52.82	61.14																																	
	47.09	46.27	51.21	70.3																																	
	57	49.59	42.63	48.01																																	
	32.57	48.65	40.82	91.51																																	
	51.91	56.02	47.84	61.38																																	
	48.83	68.36	46.13	70.6																																	
	41.69	62.11	47.03	60.34																																	
	42.91	55.31	88.72	55.39																																	
	49.44	44.98	52.41	61.62																																	
	49.3	45.74	54.34	49.8																																	
	44.41	79.51	43.61	55.14																																	
	55.12	86.93	45.34	63.85																																	
	52.35	63.31	44.52	50.64																																	
	40.44	87.08	32.69	64.58																																	
	44.27	56.36	49.96	52.5																																	
	44.64	73.41	51.6	44.03																																	
	38.68	74.42	48.68	63.93																																	
	44.6	68.05	52.33	63.57																																	
	36.51	82.43	46.51	47.13																																	
	39.28	71.46	50.11	55.68																																	
	37.43	67.97	57.31	45.86																																	
	42.53	84.02	44.83	51.74																																	
	40.25	85.39	45.33	72.9																																	
	39.3	75.37	48.94	55.85																																	
	45.99	76.91	44.6	86.35																																	
	44.41	79.91	47.67	43.56																																	
	45.44	72.09	44.02	48.99																																	
	38.39	81.16	36.91	53.54																																	
	41.32	81.55	47.62	59.03																																	
	40.28	82.04	45.82	44.08																																	
	44.45	71.8	45.65	53.1																																	
	37.01	67.39	41.17	56.98																																	
	48.83	65.34	47.13	65.15																																	
	62.45	82	43.41	49.08																																	
	36.53	82.35	63.72	50.83																																	
	39.1	80.59	45.41	53.47																																	
	36.38	68.68	78.53	50.71																																	
	45.71	73.99	60.8	58.95																																	
	38.12	67.91	66.47	47.87																																	
	43.26	76.69	52.99	51.09																																	
	44.56	78.29	48.12	52.12																																	
	43.48	73.16	55.4	74.36																																	
	45.31	60.26	43.13	61.81																																	
	35.77	59.3	60.77	56.47																																	
	49.74	68.31	50.43	52.1																																	
	38.9	96.35	47.39	60.5																																	
	54.93	67	56.16	60.13																																	
	67.42	107.73	73.02	47.31																																	
	51.38	68.71	52.56	51.43																																	
	46.08	70.53	77.32	47.13																																	
	43.11	74.86	45.47	46.26																																	
	52.53	69.29	48.75	47.13																																	
	43.18	71.08	51.47	49.4																																	
	51.87	75.72	47.48	57.99																																	
	50.96	66.48	51.99	45.45																																	
	55.03	50	66.23	57.79																																	
	61.49	72.89	50.6	65.25																																	
	50.04	63.14	67.28	62.77																																	
	45.78	64.98	52.49	59.41																																	
	46.81	53.93	52.64	50.54																																	
	54.27	67.2	61.84	55.19																																	
	54.08	60.52	57.96	73.99																																	
	90.17	60.99	70.67	65.12																																	
	55.07	59.12	54.64	62.63																																	
	44.6	57.59	46.2	33.56																																	
	55.39	47.13	58.43	63.03																																	
	50.74	60.64	51.86	89.4																																	
	40.1	79.97	47.27	67.13																																	
	62.39	67.9	47.75	61.25																																	
	48.69		34.56	49.26																																	
	66.07		61.67	46.2																																	
	61.66		51.02	58.22																																	
	51.79		47.73	53.93																																	
	47.85		44.07	65.34																																	
	47.91		57.59	52.39																																	
	57.86		48.26	54.8																																	
	50.16		45.68	65.42																																	
	49.64		48.65	55.53																																	
	47.74		42.11	78.75																																	
	52.32		44.67	49.76																																	
	52.66		49.76	64.29																																	
	49.13		77.24	48.65																																	
	64.43		55.78	38.62																																	
	51.89		38.62	45.03																																	
	44.82		45.03	44.22																																	
	47.04		44.22	35.21																																	
	50.18		35.21	57.59																																	
																																					
Figure S3: Code provided in the Supplementary data																																					
																																					
Figure S4																																					
	Wild-type	W1044X	S1444R	_agl-1																																	
ama-1	100.2203745	100.153308	99.6263176	100.1547821	101.847194	97.9980236	98.42149813	100.248021	101.330481	100.314817	98.7948592	105.1210895							98.665426	100.510846	87.32439057							101.472521	96.243218	131.981276							
T15B7.1	100	100	100	100	100	100	100	100	100	21.28827	96.08168	129.6534							28.80164	147.1734	147.6433							243.999	267.7855	638.3618							
W01A11.1	100	100	100	100	100	100	100	100	100	26.36609	52.12063	115.8653							82.21506	184.2798	98.80534							101.9423	73.98032	802.1188							
asm-1	100	100	100	100	100	100	100	100	100	20.41509	35.15458	43.84673							116.6473	153.0908	30.88539							43.63967	68.44973	373.6016							
msra-1	100	100	100	100	100	100	100	100	100	11.40559	41.55472	104.8195							20.05538	17.58153	29.17862							48.3341	53.65509	484.5795							
																																					
Figure S6																																					
	Wild-type	S1444R																																			
	n=1	n=1																																			
	109.460769	78.0849606																																			
	107.47734	118.108471																																			
	39.6725495	118.512353																																			
	148.673304	129.137948																																			
	83.9989312	129.585562																																			
	79.5206903	166.2745																																			
	97.4668681	139.347372																																			
	97.9478066	53.5334078																																			
	135.781741	132.366901																																			
	83.996865																																				
	81.3580246	408.626715																																			
	117.31252	192.862741																																			
	83.2864468	181.763129																																			
	137.435991	98.7427526																																			
	87.9472209	215.992707																																			
	105.834489	198.822921																																			
	90.9416069	263.377133																																			
	142.489985	248.020057																																			
	113.116949	256.481838																																			
	87.4409807	150.084934																																			
	68.8389214	181.574088																																			
	106.009163	125.003336																																			
	117.379407	105.467507																																			
	126.62954	265.483832																																			
	91.7619455	163.068231																																			
	69.7011933	153.390128																																			
	72.0467118	269.408624																																			
	114.636132	181.909114																																			
	131.867405	287.834088																																			
	62.0367299																																				
	80.7975401	32.5786473																																			
	118.381618	67.6807848																																			
	94.6130932	79.5111549																																			
	90.1480784	94.9114988																																			
	119.095173	61.5589472																																			
	104.89627	58.4503291																																			
		45.0802322																																			
		86.0370742																																			
		44.3524459																																			
		47.0055058																																			
		138.284222																																			
		130.214799																																			
		70.636291																																			
																																					
Figure S8																																					
Fig. S8A																																					
	CTRL	cmk-1	gpa-15	aakg-1	erm-1	CYP-13A11	bub-1	C47E12.2	CYP-13A1	ant-1.1	gsa-1	chk-1	ant-1.2	akt-1	akt-2	amx-2	CYP-33E1																				
	114.933638	105.234618	111.351761	86.6703049	34.8688275	96.5206158	140.828884	212.323311	93.6370892	57.4005308	99.1404169	57.9729488	136.901531	102.280468	51.465933	130.679254	185.839859																				
	85.0663623	173.099662	73.6505703	72.4154944	39.0723907	120.741774	111.960113	85.5984898	105.105107	70.1916642	139.768557	80.999842	58.3528613	113.078076	75.4739785	120.77117	88.977002																				
	79.3804953	124.601258	81.0942944	86.3346574	33.0055063	87.7776074	119.210035	163.181904	96.092733	72.5436433	116.541912	75.8591792	133.180873	124.852681	88.2592194	111.505308	140.228885																				
	101.358382	94.0161335	57.9576203	114.617011	72.7901028	49.2903188	110.713344	88.4145945	88.3066297	73.9373308	107.471671	32.6305037	126.049239	165.485806	86.2305883	96.8383714	138.919767																				
	119.261122	92.8806924	49.1299143	107.216154	78.3860326	67.0860603	98.9592619		94.676107	72.5493422	97.837258	69.2900137	104.793786	59.2399194	107.277424	97.8384807	115.605755																				
	102.672003	93.1736162	66.2133807	71.3916394	98.0697983	36.3228798	84.5204964		65.3241961	66.4259199	108.078043	64.2671949	136.602692	98.559711	65.8226607	74.4588055	106.380901																				
	98.0144693	96.0864311	55.7131906	84.8822865	57.0598923	43.3144458	65.4696482		62.1900409	54.1682034		43.2259053	100.657894	115.820381	90.8396481																						
	99.3135272	114.315564	62.3585096		22.5557803		98.4589484		118.689621				143.860691	159.47142	110.527778																						
	97.7374164		85.6405591		30.6711344								102.659667	91.5086655	46.2743418																						
	100.826336														93.8964534																						
	101.436248																																				
	92.5380241																																				
	119.286999																																				
	84.1091696																																				
	104.065807																																				
	111.748769																																				
	105.096133																																				
	83.155098																																				
	81.3779164																																				
	72.6887796																																				
	145.933304																																				
	85.7942688																																				
	90.4133125																																				
	96.8421045																																				
	126.950314																																				
	124.442721																																				
	72.2053041																																				
	103.351975																																				
	123.799046																																				
	76.2009535																																				
	85.8433494																																				
	96.9604389																																				
	117.196212																																				
	85.0822518																																				
	96.5139024																																				
	89.9728428																																				
	116.683914																																				
	111.747089																																				
	119.534251																																				
	81.2372451																																				
	99.2285044																																				
	103.70163																																				
	109.066406																																				
	92.6462592																																				
	94.5857053																																				
	95.29808																																				
	100.644224																																				
	118.741065																																				
	85.3166307																																				
	129.016646																																				
	105.910253																																				
	101.444912																																				
	80.7199591																																				
	82.9082298																																				
																																					
Fig. S8B																																					
	CTRL	EV	ugt-60	tax-6	ugt-62	plc-2	let-607	xdh-1	gsp-2	pkc-1	kin-1(B)	pkc-2	gsp-3	kin-1(G)	W03D8.2	sad-1	ugt-28	ugt-26																			
	65.1336958	155.184192	65.0345543	82.0919622	142.173599	171.887232	47.4617504	38.6603022	156.426377	101.616881	40.9284028	167.07646	75.1799959	96.5396728	150.431081	198.546907	156.57995	64.6681816																			
	49.7759868	54.2323034	88.6260959	65.9418425	98.7448746	178.295221	28.426102	40.5852863	106.763788	92.1651899	82.8651141	218.407579	55.8411316	104.231208	47.5994971	96.0068321	156.240141	85.2449319																			
	53.6259818	21.8379427	138.435286	64.7661256	61.0359791	190.694938	23.2353329	69.4973407	44.5398573	69.3502972	83.5018934	101.567991	20.9649243	83.3386609	46.1037854	66.2332912	80.9611351	94.8984646																			
	116.725193	23.2587899	106.505848	24.5918476	7.63330977	124.137973	11.0919599	72.4318961		94.0369715	20.0837728	41.2982309		61.6269898	68.1920477	83.8921991		60.9358422																			
	137.568959	86.9832223	112.203406	32.5245603	24.148212	110.845096	51.9579491			33.8333061		136.869485		89.8825869	76.2807336	59.4061868		37.8704782																			
	177.170184	100.845297	58.4635313	43.7688681	12.8951506	95.9719213				35.9263613		51.0582829		72.3229226	108.927798	132.522977		170.588277																			
	131.190038	40.3633188	47.7199798	65.1459863	117.66828	116.860211				27.7688535		108.903619		65.8197599	61.0749561	225.095897																					
	67.686042	34.5123711	38.9886801	62.7503681		83.298675				18.594668		45.6104624			48.1140579																						
	60.6082169	43.2967692	42.8551875			154.316014				17.2292571		110.077306			145.78879																						
	173.598884	47.8911771	73.0424985							68.3801985					229.760015																						
	66.9168196	52.8939655								95.3623639					297.595843																						
	81.5428769																																				
	92.5605384																																				
	108.574885																																				
	117.3217																																				
	118.290997																																				
	97.0039149																																				
	84.7050878																																				
	102.283952																																				
	111.220129																																				
	86.4959188																																				
	72.9212191																																				
	75.8035603																																				
	145.068891																																				
	106.20633																																				
	101.379771																																				
	98.620229																																				
	60.418564																																				
	88.258228																																				
	156.597952																																				
	94.7252562																																				
	126.307211																																				
	83.9757234																																				
	84.5760956																																				
	89.2989422																																				
	115.842028																																				
	89.1183046																																				
	120.608084																																				
	90.2736115																																				
	140.817993																																				
	84.6448615																																				
	74.5371454																																				
	104.102735																																				
	45.8349565																																				
	126.184698																																				
	123.877611																																				
	64.5859304																																				
	90.6397943																																				
	111.545329																																				
	111.627113																																				
	94.0393516																																				
	127.562482																																				
	93.5342606																																				
	121.210736																																				
	69.8477867																																				
	49.9303863																																				
	218.359664																																				
	79.1870839																																				
	67.9300827																																				
	160.280205																																				
	99.46795																																				
	70.3713179																																				
	40.4206673																																				
	97.839549																																				
	59.7342813																																				
	140.400488																																				
	131.485542																																				
	89.6458106																																				
	86.212784																																				
	130.855855																																				
	116.830731																																				
	76.4548199																																				
	177.021426																																				
	189.894567																																				
	59.5532791																																				
	76.3115462																																				
	58.1373949																																				
	39.0817869																																				
																																					
Fig. S8C																																					
	CTRL	EV	egl-30	dhs-12	snf-9	CYP-33E2	adr-3	F15E6.6	dhs-31	vdac-1	Y39G8B.1	CYP-13A6	C47A4.3	CYP-13A7	F20G2.1	C25A6.1	CYP-13A5																				
	140.992402	107.044494	201.169398	108.976927	182.709409	92.2783574	104.550019	160.520707	59.8054308	81.2422498	97.3811737	146.791049	145.314664	124.385829	141.578488	145.826132																					
	137.234137	100.309757	119.21346	170.93029	160.656123	139.779389	131.913442	132.411597	60.8182806	80.271998	107.842334	160.243812	116.615221	112.084112	135.923457	93.2176851	169.822002																				
	64.3875289	62.1498018	216.074794	195.341544	164.679502	155.965142	80.4343447	217.259431	70.1663399	92.8296062	98.3283259	150.160162	74.6591008	129.385794	57.8679937	93.4378839	198.605952																				
	85.0053112	87.694661	121.745048	111.691168	45.9935055	122.169414	104.152176	96.0010645	114.480143	88.0381933	57.5611974	184.600435	63.0434548	141.712644	125.308958	92.632311	201.755272																				
	93.3568376		125.199724	115.560071	78.234751	132.185129	67.1989201	80.0208322	63.2197896	113.398629	107.395206	140.790498	148.298586	95.502104	151.645791	110.016045	207.095825																				
	91.1384391		242.454004	145.234171	80.0947492	146.469804	53.2394871			65.2039136		135.968842	105.977899	37.65455	86.746706	97.9284614	183.325277																				
	78.7517859		193.755102	115.369184	197.118706	102.542884	106.863929			92.3092871		96.1144498	95.5154391	87.853884	118.644412	85.8738338	132.246354																				
	109.133558		32.9311332		150.314092		89.9510299			61.767961		149.885483	120.466278	101.074388	94.9418672	124.714388																					
	102.755188		97.7787148		204.721593		40.324123			92.9615806																											
	111.491696		71.6055301		162.448433		89.4964332																														
	72.5065765				129.469922																																
	67.580223																																				
	100.489715																																				
	145.176602																																				
	126.159775																																				
	83.3202554																																				
	128.129028																																				
	62.9870619																																				
	122.666996																																				
	76.7368836																																				
	152.239309																																				
	90.9733172																																				
	79.4399941																																				
	77.3473793																																				
	129.176478																																				
	141.536626																																				
	100.939361																																				
	68.7248322																																				
	93.6566549																																				
	65.9660483																																				
	56.3956444																																				
	70.617213																																				
	65.4943851																																				
	92.9515553																																				
	154.905258																																				
	159.635944																																				
	111.29808																																				
	106.52818																																				
	103.20086																																				
	78.9728802																																				
	109.670068																																				
	102.104143																																				
	124.363485																																				
	63.862304																																				
	74.3756014																																				
	79.2879628																																				
	118.093851																																				
	95.529839																																				
	111.256077																																				
	100.266811																																				
	121.189858																																				
	111.924708																																				
	94.4600538																																				
	116.829783																																				
	76.7854549																																				
	103.431792																																				
	111.847959																																				
	88.7897347																																				
	125.064302																																				
	67.4574003																																				
	103.408812																																				
	130.125552																																				
	89.9645925																																				
	101.872216																																				
	113.572694																																				
	90.6460512																																				
	94.5493472																																				
	79.2695477																																				
	119.875334																																				
	164.853957																																				
	89.9201199																																				
	77.6702203																																				
	97.5177775																																				
	64.5404758																																				
	113.471473																																				
	72.150643																																				
	120.277604																																				
	194.516075																																				
	102.065539																																				
	113.703562																																				
	78.9839762																																				
	102.954757																																				
	43.8427615																																				
	82.5733643																																				
	101.458736																																				
	59.6236256																																				
	103.892427																																				
	116.660852																																				
	105.653638																																				
	104.560959																																				
	83.5076192																																				
	77.7984006																																				
	84.5972963																																				
	123.328809																																				
																																					
Fig. S8D																																					
	CTRL	EV	jmjd-1.2	ocr-4	CYP-13A3	ant-1.3	ugt-8	CYP-13A2	Êagl-1	srdf-3	snf-7	ugt-32	CYP-13A4	let-60	snf-5	ant-1.4	cat-2	CYP-33C3																			
	125.429921	113.186339	70.2164637	91.4723256	130.843454	98.6711722	165.365505	139.358025	192.039855	55.0848738	60.6836984	153.772344	95.5771724	134.648295	117.116896	173.3678	152.847375	151.004927																			
	147.259843	121.318128	50.1835779	76.0010986	126.681287	139.900265	127.380812	103.096109	100.596105	79.880301	82.68736	101.507877	92.489441	123.348449	82.7132832	88.2265267	139.756891	100.523677																			
	68.9205531	86.7169493	78.0635705	70.2519292	121.751422	119.542602	95.1210889	129.302933	90.7155568	29.5172256	109.72167	126.060792	105.952978	85.4969999	68.1971541	113.716252	164.779777	119.062748																			
	115.028066	95.7588095	49.9498919	99.4067122	93.5116053	81.7097054	110.69316	124.566968	112.827449	59.4538997	131.011019	70.542335	63.5326484		49.4286415	113.293124	47.4300488	91.66174																			
	114.202251	83.0197744	55.2134079	108.041856	102.517944	57.5853624	113.862708	117.945921	80.2962157	59.9553843		160.242321	84.5776101		43.613772	89.2760137																					
	87.4908615	136.322736		101.852245	74.8928073	71.0100983		143.355159	51.7609638	62.1918992		95.2922414																									
	93.3385237	95.3691584		106.460215				98.1699729	76.5489546	58.9621118																											
	75.7556798	83.2703671		77.2771405						75.0603338																											
	72.5743016	107.657813																																			
	94.3402027	77.3799256																																			
	95.5846465	129.570255																																			
	115.463654	87.5419289																																			
	105.724607	92.1557384																																			
	111.792536	95.8566601																																			
	110.203472	79.9254847																																			
	59.7948302	60.2399462																																			
	107.096052	141.615968																																			
	98.016143	113.094019																																			
	86.0007461	125.554541																																			
	122.947417	124.093859																																			
	85.5466595	70.0268129																																			
	97.5289256	80.3247874																																			
	101.317426	63.0588537																																			
	104.09836	104.351882																																			
	111.4616	123.284618																																			
	120.849715	109.304646																																			
	72.2330077	106.530677																																			
	117.675011	169.263397																																			
	104.70442	77.487814																																			
	105.224984	86.0371199																																			
	91.807577	60.6809921																																			
	80.5880083																																				
	89.5914915																																				
	94.4168105																																				
	111.661913																																				
	103.568462																																				
	100.761323																																				
	91.269059																																				
	117.728875																																				
	99.1791152																																				
	94.9655424																																				
	85.1678312																																				
	111.689577																																				
	96.6247423																																				
	97.9011551																																				
	115.954372																																				
	120.717456																																				
	68.8022742																																				
	110.183712																																				
	101.764742																																				
	105.622787																																				
	83.3145567																																				
	86.5675424																																				
	112.54666																																				
	91.3638799																																				
	100.104803																																				
	57.8633865																																				
	71.3048302																																				
	106.696898																																				
	142.813114																																				
	129.853088																																				
	113.878561																																				
	89.9645018																																				
	104.808563																																				
	150.029054																																				
	103.948594																																				
	37.3707262																																				
																																					
Fig. S8E																																					
	CTRL	EV	CYP-14A1	cat-1	pgp-8	CYP-13B2	aakg-3	CYP-13B1	dcn-1	gnrr-1	CYP-14A2	ugt-23	OP50																								
	142.678282	115.730681	117.305478	117.903342	58.0252239	207.926294	198.506861	142.913843	68.9050339	49.47921	148.015746	183.98591	159.886125																								
	149.705968	163.207054	72.3313374	91.8820094	62.2342727	165.67229	121.646559	112.522952	55.4598179	77.8925079	76.9850068	150.420699	62.3619947																								
	66.2814725	131.102608	81.8515103	50.2316927	88.131335	186.090387	48.0149964	64.811977	109.434824	77.26885	102.630161	125.931225	78.3922243																								
	95.6236753	71.7560862	90.984934	106.703891	28.0302368	141.832277	147.561886	98.7900083	89.3718322	78.6934682	98.439972	132.715088	98.8047836																								
	73.8192992	81.0131788	116.090083	56.6977552	45.1924919	199.580698	167.209571	51.452599	106.080796	70.1181548	93.0785071	132.812379	77.808413																								
	159.137741	151.639637	99.6556908	70.5022475	50.4648314	118.72742	114.905418	65.3792491	103.824931		135.340198	150.614778	118.728723																								
	99.73478	153.708919	106.240559	94.4126434	63.3361631	175.147749	179.291641	66.2418908	109.945761		97.4095649	113.549778	93.8679217																								
	70.4548868		105.031711	93.2692964	106.629716	172.97323	48.7647805	98.294547			68.2031792	152.61092	110.149815																								
	75.6108287		75.9943039	107.91046	148.48489	126.306659	57.2885749				110.194648	162.089407																									
	66.9530658		59.280593		54.2651067	137.662925						147.112304																									
	126.51983		84.5276522		107.470159							122.644469																									
	140.536263				69.4283273							125.214963																									
	106.780244				125.153271																																
	68.147371				104.066071																																
	79.2496544																																				
	78.7666377																																				
	123.622708																																				
	79.9489115																																				
	55.8892922																																				
	54.1352821																																				
	114.481644																																				
	61.5718438																																				
	160.556416																																				
	99.5435489																																				
	97.8768078																																				
	115.580058																																				
	136.793487																																				
	98.0649812																																				
	155.95888																																				
	199.461033																																				
	138.619869																																				
	74.8606333																																				
	45.049277																																				
	64.656409																																				
	105.308281																																				
	121.931684																																				
	64.9592678																																				
	85.6357408																																				
	48.949477																																				
	71.1153086																																				
	125.429158																																				
	201.160209																																				
	109.982316																																				
	91.6351402																																				
	86.5920498																																				
	65.3960402																																				
	104.531887																																				
	94.9530932																																				
	33.5873297																																				
	112.161934																																				
	82.9952824																																				
	130.8624																																				
	111.749949																																				
	95.2751768																																				
	131.736319																																				
	78.3677982																																				
	69.0130743																																				
	151.763464																																				
	100.786474																																				
	67.8432282																																				
	72.7233269																																				
	75.8723872																																				
	131.011121																																				
	123.45391																																				
	95.3260978																																				
	98.6896554																																				
	147.770584																																				
	59.5543149																																				
	135.446981																																				
	68.1143486																																				
	71.6441093																																				
	165.895018																																				
	152.805566																																				
	42.364799																																				
	82.6804334																																				
	59.3273497																																				
	96.9268335																																				
	103.821857																																				
	65.3315441																																				
	52.102491																																				
	133.847018																																				
	157.773547																																				
	90.4186866																																				
	85.4100478																																				
	73.1463558																																				
	70.7939277																																				
	132.378931																																				
	117.093181																																				
	117.882412																																				
																																					
Fig. S8F																																					
	CTRL	EV	CYP-13B2	ugt-23	erm-1	chk-1	pkc-1	CYP-13A6	CYP-13A5	srdf-3	OP50																										
	117.072593	83.2143776	88.960139	125.00243	118.551252	79.2677385	87.6749357	116.156208	136.025439	46.5550992	127.114512																										
	94.2681483	107.172483	95.6323641	83.4950464	104.538593	75.8897345	128.983774	120.893431	102.986369	54.819145	132.355573																										
	93.8307981	106.768283	144.794117	84.6766624	86.9142815	125.348539	109.308676	115.880028	35.0775597	136.300903	69.7606676																										
	107.996511	125.752426	109.213194	80.6494773	68.1340317	70.6131362	142.176045	113.431655	119.302231	33.3201584	121.397245																										
	112.474022	87.4106632	98.4965669	69.0530259	63.3665273	89.6001285	143.952407	76.1861127	137.559071		144.113276																										
	68.5330177	81.1066819	83.8556622	66.9729958	106.574363	74.1419076	123.258323	80.1998564	105.512685	94.6006896	92.9421524																										
	97.0460336	66.3468591	126.342076	52.889447	104.183563	68.1546235	114.320148	57.8991231	125.989361	65.675381	69.7479944																										
	108.778876	93.9899997	125.782125		166.406509	59.5554361		114.348917	124.973116	92.1042584	90.7229897																										
	91.7045149	86.9766044	89.2314329	136.915454			112.545334		85.8794666	122.262613	50.588442																										
	84.1198934		127.573608	153.445062	66.6599885	113.061518	100.871305	63.2192697	94.8453811	113.003826	101.257148																										
	92.1150075	83.2143776	129.086437	120.812102	64.3146801	129.004504	105.659216	72.1818504		97.165742																											
	87.8560566	107.172483	115.435307	102.739389	64.9924189	78.5658652	90.3591557	81.7685082	44.5428999	133.121375	127.114512																										
	119.051245	106.768283		68.4883387		134.902077	97.193341	46.5532909	93.974695	109.938266	132.355573																										
	121.968814	125.752426	74.0048818	114.621965		115.97546	75.0591919	48.7419639	87.4932581	80.3292892	69.7606676																										
	103.184469	87.4106632	134.959022	67.2859577		66.6537752	59.2342892	48.4645323	82.5355984		121.397245																										
	65.5601696	81.1066819	116.126002	81.9987277		166.281212		38.9194357	92.1879501		144.113276																										
	42.5959689	66.3468591	224.066542			75.1026127			87.1529303		92.9421524																										
	145.037856	93.9899997	138.706512			154.132272			147.510166		69.7479944																										
	124.072455	86.9766044	132.230792			105.30672			114.991711		90.7229897																										
	123.853249		135.970307						90.3656895		50.588442																										
	127.257869		144.923687						32.5463193		101.257148																										
	71.6224317		137.675676						95.6220217																												
	118.736083		174.457131																																		
	107.376429		135.814536																																		
	115.600598		149.323971																																		
	107.628979		179.799111																																		
	79.5538556		144.926902																																		
	88.8940758		157.49001																																		
	82.2099785		142.716663																																		
	155.492489																																				
	103.860802																																				
	105.330632																																				
	100.321154																																				
	85.8961452																																				
	83.308763																																				
	65.7900151																																				
	52.0737517																																				
	89.8167913																																				
	100.882026																																				
	104.86239																																				
	123.770161																																				
	132.297291																																				
	110.883197																																				
	80.1003834																																				
	105.314009																																				
	114.004713																																				
	28.0795708																																				
	138.246361																																				
	117.147131																																				
	132.970482																																				
	106.151308																																				
	70.569603																																				
	92.8308309																																				
	95.1811																																				
	107.811576																																				
	97.9121383																																				
	65.4638185																																				
	95.5550134																																				
	114.797847																																				
	90.2706262																																				
	111.504329																																				
	128.384469																																				
	98.5248272																																				
	94.5942553																																				
																																					
	142.729802																																				
	80.4469696																																				
	66.3813127																																				
	88.9271124																																				
	118.347384																																				
	62.3395061																																				
	150.353127																																				
	119.336347																																				
	79.8265773																																				
	92.0032871																																				
	99.3085762																																				
	52.4654987																																				
	81.1281222																																				
	123.655326																																				
	70.6609027																																				
	132.050454																																				
	92.9500668																																				
	47.709297																																				
	80.7917562																																				
	102.517009																																				
	191.975687																																				
	124.095881																																				
	64.9325808																																				
	112.915167																																				
	106.338531																																				
	96.1379194																																				
	57.4973967																																				
	154.081297																																				
	108.097107																																				
																																					
																																					
	156.582839																																				
	100.268158																																				
	118.818922																																				
	110.427167																																				
	120.535371																																				
	55.7835272																																				
	37.5840149																																				
																																					
																																					
	106.923002																																				
	135.453019																																				
	89.6518764																																				
	113.350286																																				
	92.4114529																																				
	56.5295421																																				
	107.714454																																				
	97.9663676																																				
																																					
	100.813169																																				
	118.291924																																				
	118.781111																																				
	124.940244																																				
	81.0798945																																				
	68.3650186																																				
	144.423117																																				
	124.789252																																				
	69.4152448																																				
	56.0932122																																				
	93.0078125																																				
																																					
	72.4257968																																				
	106.488839																																				
	119.21293																																				
	117.323189																																				
	61.494627																																				
	91.6778597																																				
	141.570477																																				
	92.9224857																																				
	96.8837967																																				
																																					
	83.8455726																																				
	119.286022																																				
	120.246957																																				
	122.687855																																				
	78.1884789																																				
	136.629643																																				
	84.2336088																																				
	92.6660578																																				
	95.8788622																																				
	105.931956																																				
	60.4049863																																				
																																					
Figure S9																																					
	Days of adulthood	Wild-type	agl-1(S1444R)	EV	chk-1 KD	pkc-1	pkc-2	B0024.13																													
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	7	0																																			
	8	1																																			
	8	1																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	8	0																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	9	1																																			
	10	1																																			
	10	0																																			
	10	0																																			
	10	0																																			
	10	0																																			
	10	0																																			
	10	0																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	1																																			
	11	0																																			
	11	0																																			
	11	0																																			
	11	0																																			
	11	0																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	1																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	12	0																																			
	6		0	0																																	
	6		0	0																																	
	6		0	0																																	
	6		0	0	0																																
	6		0		0																																
	6		0		0																																
	6		0																																		
	6		0																																		
	6		0																																		
	6		0																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		1																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	7		0																																		
	8		1																																		
	8		1																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	8		0																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		1																																		
	9		0																																		
	9		0																																		
	9		0																																		
	10		1																																		
	10		1																																		
	10		0																																		
	11		1																																		
	11		1																																		
	11		1																																		
	11		0																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		1																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
	12		0																																		
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	2			0																																	
	2			0																																	
	3			0																																	
	3			0																																	
	3			0																																	
	5			0																																	
	5			0																																	
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	6			1																																	
	6			1																																	
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	8			1																																	
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	8			0																																	
	8			0																																	
	8			0																																	
	9			1																																	
	9			1																																	
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	9			1																																	
	9			1																																	
	9			1																																	
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	9			0																																	
	9			0																																	
	9			0																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			1																																	
	10			0																																	
	10			0																																	
	10			0																																	
	10			0																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			1																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	11			0																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			1																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	12			0																																	
	7				1																																
	7				0																																
	7				0																																
	7				0																																
	8				1																																
	8				1																																
	8				0																																
	8				0																																
	9				1																																
	9				1																																
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	9				0																																
	10				1																																
	10				1																																
	10				1																																
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	10				0																																
	10				0																																
	10				0																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				1																																
	11				0																																
	11				0																																
	11				0																																
	11				0																																
	11				0																																
	11				0																																
	12				1																																
	12				1																																
	12				1																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	12				0																																
	2					0																															
	2					0																															
	3					0																															
	3					0																															
	3					0																															
	5					0																															
	5					0																															
	5					0																															
	6					0																															
	7					1																															
	7					1																															
	7					0																															
	8					1																															
	8					0																															
	8					0																															
	8					0																															
	8					0																															
	8					0																															
	9					1																															
	9					1																															
	9					1																															
	9					1																															
	9					1																															
	9					1																															
	9					0																															
	9					0																															
	9					0																															
	9					0																															
	9					0																															
	10					1																															
	10					0																															
	10					0																															
	11					1																															
	11					1																															
	11					0																															
	12					1																															
	12					1																															
	12					1																															
	12					0																															
	2					0																															
	2					0																															
	3					0																															
	3					0																															
	5					0																															
	6					1																															
	6					0																															
	7					0																															
	7					0																															
	7					0																															
	7					0																															
	7					0																															
	8					0																															
	8					0																															
	8					0																															
	8					0																															
	9					1																															
	9					1																															
	9					1																															
	11					1																															
	11					0																															
	11					0																															
	12					1																															
	12					1																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	12					0																															
	2						0																														
	2						0																														
	2						0																														
	2						0																														
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	2						0																														
	2						0																														
	2						0																														
	2						0																														
	2						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	3						0																														
	5						0																														
	5						0																														
	6						1																														
	6						1																														
	6						1																														
	6						1																														
	6						0																														
	6						0																														
	6						0																														
	7						1																														
	7						1																														
	7						0																														
	7						0																														
	7						0																														
	8						1																														
	8						1																														
	8						1																														
	8						1																														
	8						1																														
	8						1																														
	8						1																														
	8						0																														
	8						0																														
	8						0																														
	8						0																														
	8						0																														
	9						1																														
	10						1																														
	10						1																														
	10						1																														
	10						1																														
	11						1																														
	11						1																														
	11						1																														
	11						1																														
	11						0																														
	11						0																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						1																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	12						0																														
	2							0																													
	2							0																													
	3							0																													
	3							0																													
	5							0																													
	5							0																													
	5							0																													
	6							1																													
	6							1																													
	6							0																													
	6							0																													
	6							0																													
	7							1																													
	7							0																													
	7							0																													
	8							1																													
	8							1																													
	8							1																													
	8							1																													
	8							1																													
	8							0																													
	9							1																													
	9							1																													
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	9							0																													
	10							1																													
	10							1																													
	10							1																													
	10							1																													
	10							1																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	10							0																													
	11							1																													
	11							1																													
	11							0																													
	11							0																													
	11							0																													
	11							0																													
	11							0																													
	12							1																													
	12							1																													
	12							1																													
	12							1																													
	12							1																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
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	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
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	12							0																													
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	12							0																													
	12							0																													
	12							0																													
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	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
	12							0																													
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	12							0																													
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	12							0																													
	12							0																													
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	12							0																													
	12							0																													
																																					
Figure S10																																					
Fig. S10A																																					
	W1044X EV	W1044X chk-1	_agl-1 EV	_agl-1 chk-1																																	
	106.987893	56.7595934	61.4949944	89.3393227																																	
	110.822196	68.5079214	166.756163	71.0084703																																	
	74.315657	82.7225661	94.1983041	102.981746																																	
	165.494333	84.4041523	86.9053484	103.302806																																	
	74.3445643	83.7933035	105.259234	139.864817																																	
	67.3294387	44.9903879	47.7423275	222.030571																																	
	241.018402	66.6394598	138.616621	130.442595																																	
	75.2935407	72.0890664	113.923817	144.278429																																	
	57.4247528	60.6248473	84.7845222	229.603619																																	
	73.3203998	46.5065602	100.318669	56.092004																																	
	62.4535978			73.4865772																																	
	75.8367932	50.6666587	112.2578	115.897652																																	
	133.179642	61.4189715	91.1996436	54.8081146																																	
	93.5795863	46.4604626	78.9032229																																		
	92.9523859	67.2628547	94.9821266	77.0619043																																	
	114.227269	39.4027027	61.8808596	41.2254686																																	
	81.4195485	57.8113079	123.281408	102.399892																																	
		43.5413944	137.49494	32.9758649																																	
	75.3246018	44.1989396		59.4900768																																	
	108.381899	58.1095448		90.4274373																																	
	60.6947797	82.9682854		86.9238206																																	
	120.301599			106.625605																																	
	136.524935	86.9865682		124.250675																																	
	98.2811276	106.092149																																			
	111.129248	107.634889																																			
	89.3618098	118.942441																																			
		122.786752																																			
	93.9315827	120.195768																																			
	137.243816	101.473483																																			
	78.4079155	169.554179																																			
	67.4466437	145.208119																																			
	104.685982	170.45421																																			
	137.475466	171.851273																																			
	99.6535702	136.19378																																			
	92.1397302																																				
	89.0152946																																				
																																					
Fig. S10B																																					
	W1044XÊ	W1044X pimozide	_agl-1	_agl-1 pimozide																																	
	121.551593	58.0167844	92.126215	132.544274																																	
	125.050016	75.7012587	88.0065894	78.733911																																	
	129.37207	77.6343821	220.472397	77.7898721																																	
	54.5921268	53.5455271	138.80146	108.613484																																	
	110.360654	52.1292638	97.6373962	71.4892852																																	
	111.63591	105.951119	106.794243	118.661484																																	
	43.9919802	67.9515365	23.5903389	86.6181954																																	
	136.115839	110.739517	46.3948648	128.971757																																	
	100.946274	44.2077567	91.1377693	181.232195																																	
	91.3330126	106.124911	54.759001	97.5541874																																	
	90.0719745	84.9625874	89.7052559	109.202268																																	
	67.7733955	136.339477	157.843196	95.2458979																																	
	82.8707261		118.394469																																		
	134.334428	98.473902	98.8793484	36.2254491																																	
		117.494557	120.6618	79.7890296																																	
	117.312	105.085136	48.0100351	147.223201																																	
	75.5331696	128.623854	106.785621	61.5898378																																	
	105.384796	106.970667		126.639742																																	
	116.041077	47.1186964	68.8641049	158.894837																																	
	133.054051	105.122093	87.2866964	50.6556465																																	
	55.5083024	81.8610692	136.850514	157.638088																																	
	47.1359132	111.188772	94.0435376	149.898363																																	
	29.8422764		116.203943	81.3419335																																	
	159.640728	128.264127	129.828323																																		
	117.408028	132.073648	66.9228811	96.372794																																	
	143.139656	112.952551		56.3896631																																	
		125.235552	87.9065701	77.9692998																																	
	97.4998876	128.767355	84.6723233	102.232777																																	
	125.998089	111.257481	108.68917	82.9751985																																	
	77.6194182	130.23073	54.5213948	93.6826145																																	
	89.966563	158.123303	108.780408	72.9424644																																	
	120.445175	112.01369	116.242244	79.4414987																																	
	94.2111412	132.752625	70.8404345	25.7080169																																	
	93.4665818	136.739333	83.2273038	46.0654472																																	
	99.1695012	129.532912	109.236599	84.8999384																																	
	125.319112		121.44541	101.39041																																	
	88.859288		134.82178	68.887843																																	
	87.4452436		112.438768	91.9490905																																	
			107.177595																																		
																																					
Fig. S10C																																					
	W1044XÊ	W1044X rabusertib	_agl-1	_agl-1 rabusertib																																	
	130.964338	202.253539	158.132422	197.105129																																	
	77.3012582	215.982047	64.2150015	77.0327944																																	
	152.260464	203.686048	161.163606	187.680732																																	
	59.6278369	95.4354084	67.6940451	96.680776																																	
	77.9517198	223.051416	48.8893639	97.5160558																																	
	79.3090115	273.327401	86.2266015	59.7233673																																	
	127.61174	88.4538824	117.13482	137.776343																																	
	109.931917	83.2743732	96.5441407	206.965356																																	
	85.0417153			141.345904																																	
		48.9122809	82.7917257	165.893993																																	
	139.555936	83.2569162	113.845121	160.440183																																	
	117.052435	111.239329	59.4393852	131.585934																																	
	133.890757	81.9628312	113.354255																																		
	62.2479963	98.4089554	95.7437032	114.238445																																	
	81.1265575	78.7302868	89.9427055	150.298445																																	
	102.343879	74.5304397	110.166443	71.8877615																																	
	122.863465	67.4119842	101.374427	94.7207468																																	
	85.4408328	90.7226085	128.941868	61.8624738																																	
	102.471054	68.5932221	104.400367	83.8124503																																	
	53.0070874	84.2598913		67.842804																																	
		44.8340753	37.4403381																																		
	103.713439	127.531697	79.6111382	66.3797111																																	
	103.561471		69.0996215	83.532617																																	
	57.3114375	79.5878035	169.269527	50.8228219																																	
	82.4652404	162.200635	125.224896	40.9211203																																	
	139.030565	97.0018065	138.452759	118.479994																																	
	101.736469	95.2277252	80.9017207	55.8161143																																	
	112.0627	70.6340538		62.1591969																																	
	104.794517	117.514236		28.8744956																																	
	63.2801399	104.280333																																			
	106.685756	95.6058538																																			
	125.358265	61.9026858																																			
																																					
Fig. S10D																																					
	W1044X EV	W1044X aak-2	_agl-1 EV	_agl-1 aak-2	EV	aak-2																															
	89.1504725	89.1044265	96.0716793	143.041295	89.9116057	225.773195																															
	107.683155	72.2463176	119.870352	84.6510219	57.4969813	208.017499																															
	72.2744381	45.6310457	71.1990556	113.858523	180.736396	130.030667																															
	111.541722	41.6893496	73.8746613	150.521616	186.573342	186.344475																															
	109.274936	45.0596718	101.470617	150.987127	58.190229	115.396246																															
	106.398908	60.9863291	124.534115	215.106584	60.1827449	181.858303																															
	103.676367	26.3933322	105.34567	164.605021	83.5639659	195.155657																															
		79.4367789	86.9121808	182.643969	51.5748851	133.680082																															
	65.9945132	69.0450548	161.352132	209.481135	32.1492048	77.0410412																															
	74.7034136	42.3403798	77.5778529	198.358455	199.620645	105.830134																															
	77.0474424	88.846412	81.7916847	260.118334		140.278188																															
	90.0819347	72.8636255		203.669112	44.2174018	184.052687																															
	30.4228664	123.672552	98.6296052		101.870218	127.950093																															
	38.0450013	62.920486	136.383206	67.240652	103.078514																																
	105.082582	70.707529	35.9302938	44.9634982	94.4302712	53.6955406																															
	62.4868055		95.4043738	66.106826	119.805109	133.499509																															
	62.4525797	170.948275	117.300153	43.7439754	136.598486	126.708657																															
	157.998147	115.201183	54.0551753	39.7512602		104.580104																															
	105.9525	172.498921	131.693198	74.5190835	101.65676	100.491911																															
	115.099642	91.4130803	130.603996	49.9448045	73.1471295	112.842515																															
	65.3624085	105.31307		72.535391	114.593851	142.718967																															
	94.577898	52.2462036	94.960306	63.7913542	110.602259	104.822802																															
	70.307223	110.53308	108.373754	55.7622469		124.019436																															
	159.509768	154.061796	138.374523	39.6124171		120.896434																															
	159.574305		105.24207	37.369977		161.652136																															
	237.149027	115.13589	85.6582898	55.0898108																																	
	128.151942	89.4932818	67.391057			60.134325																															
		70.065775		110.449723		49.3292304																															
	29.0542651	78.0785542		100.653806		39.8547166																															
	165.630141	66.2050998		137.17505		47.4834697																															
	108.472147	91.8321567		114.770423		22.5640841																															
	90.694341	47.0816515		150.292927																																	
	106.149106	104.884427		110.701902																																	
		86.1279975		90.188978																																	
				86.1148084																																	
				89.8885989																																	
																																					
Fig. S10E																																					
	W1044X	_agl-1	W1044X aak-2	_agl-1 aak-2																																	
	15.68525	73.28675	139.2654	54.15781	41.35419	493.3346	49.08741	40.91628	41.60101	26.5695	52.45881	282.8594