Dataset EV9 Table of Reactome terms identified analyzing the 23 common mRNAs that are translationally regulated by praja2 and bound to DDX6 only in U87MG praja2KO cells Term Overlap P-value Adjusted P-value Old P-value Old Adjusted P-value Odds Ratio Combined Score Genes Regulation Of Commissural Axon Pathfinding By SLIT And ROBO R-HSA-428542 3/9 0.0012699010388827446 0.6755873526856201 0 0 19.0224609375 126.85729763625473 ROBO2;SLIT2;NTN1 Activation Of C3 And C5 R-HSA-174577 2/6 0.009267228611405784 0.9999953328203589 0 0 18.987329434697855 88.88483288947205 C4A;C5 Neuronal System R-HSA-112316 18/386 0.011643433670184373 0.9999953328203589 0 0 1.8814298836497245 8.378031526029574 KCNH5;SYT2;KCND2;GABRA5;ACTN2;RASGRF2;AKAP5;GABRG3;PPM1E;CPLX1;SYT7;PTPRD;CACNB4;KCNMB1;LRFN1;DLGAP1;APBA1;KCNK2 Initial Triggering Of Complement R-HSA-166663 3/21 0.01598903803904342 0.9999953328203589 0 0 6.3369140625 26.20853815491494 C4A;MASP1;MBL2 ROBO Receptors Bind AKAP5 R-HSA-9010642 2/8 0.016717876274931688 0.9999953328203589 0 0 12.656920077972709 51.78296216374456 ROBO2;AKAP5 Lectin Pathway Of Complement Activation R-HSA-166662 2/8 0.016717876274931688 0.9999953328203589 0 0 12.656920077972709 51.78296216374456 MASP1;MBL2 Beta-oxidation Of pristanoyl-CoA R-HSA-389887 2/9 0.021131595887768605 0.9999953328203589 0 0 10.848231690336954 41.84147692014946 ACOXL;SYCP2 Neurotoxicity Of Clostridium Toxins R-HSA-168799 2/10 0.025969612336673737 0.9999953328203589 0 0 9.491715399610136 34.65262206475186 SV2C;SYT2 Protein-protein Interactions At Synapses R-HSA-6794362 6/88 0.026059347038714997 0.9999953328203589 0 0 2.78925679237146 10.173475990926931 PTPRD;SYT2;LRFN1;DLGAP1;APBA1;SYT7 IRF3-mediated Induction Of Type I IFN R-HSA-3270619 2/13 0.04278744216385036 0.9999953328203589 0 0 6.902002480949849 21.75173416514414 PRKDC;DTX4 Sensory Processing Of Sound By Outer Hair Cells Of Cochlea R-HSA-9662361 4/53 0.04728520716353855 0.9999953328203589 0 0 3.104916330524382 9.4748315764515 KCNMB1;PCDH15;LHFPL5;XIRP2 Creation Of C4 And C2 Activators R-HSA-166786 2/14 0.04908543896647397 0.9999953328203589 0 0 6.326510721247564 19.069323361766887 MASP1;MBL2 DCC Mediated Attractive Signaling R-HSA-418885 2/14 0.04908543896647397 0.9999953328203589 0 0 6.326510721247564 19.069323361766887 ABLIM2;NTN1 Complement Cascade R-HSA-166658 4/55 0.05294614742422502 0.9999953328203589 0 0 2.9828479336940257 8.765038901737585 C4A;C5;MASP1;MBL2 cGMP Effects R-HSA-418457 2/15 0.055693806671090036 0.9999953328203589 0 0 5.839556155345629 16.86397438877333 PDE1A;KCNMB1 Neurexins And Neuroligins R-HSA-6794361 4/57 0.058958789066462174 0.9999953328203589 0 0 2.869992246058413 8.124708603799247 SYT2;DLGAP1;APBA1;SYT7 STING Mediated Induction Of Host Immune Responses R-HSA-1834941 2/16 0.06259245359879981 0.9999953328203589 0 0 5.4221665274296855 15.025422909674162 PRKDC;DTX4 Glutathione Conjugation R-HSA-156590 3/36 0.06480735543239213 0.9999953328203589 0 0 3.453835227272727 9.450854265572858 GSTM3;MGST2;OPLAH Other Semaphorin Interactions R-HSA-416700 2/19 0.08484136055063767 0.9999953328203589 0 0 4.464625616328402 11.014106889349165 SEMA4D;PLXNA4 Aflatoxin Activation And Detoxification R-HSA-5423646 2/19 0.08484136055063767 0.9999953328203589 0 0 4.464625616328402 11.014106889349165 AKR7A3;MGST2 Ras Activation Upon Ca2+ Influx Thru NMDA Receptor R-HSA-442982 2/19 0.08484136055063767 0.9999953328203589 0 0 4.464625616328402 11.014106889349165 ACTN2;RASGRF2 Scavenging By Class A Receptors R-HSA-3000480 2/19 0.08484136055063767 0.9999953328203589 0 0 4.464625616328402 11.014106889349165 MARCO;MASP1 Integrin Cell Surface Interactions R-HSA-216083 4/66 0.09023391090411506 0.9999953328203589 0 0 2.4522441765040086 5.8985054568578255 ITGAM;ITGA4;FN1;THBS1 Sensory Processing Of Sound By Inner Hair Cells Of Cochlea R-HSA-9662360 4/67 0.09411762033039642 0.9999953328203589 0 0 2.4131954151523622 5.702887534146522 KCNMB1;PCDH15;LHFPL5;XIRP2 Synaptic Adhesion-Like Molecules R-HSA-8849932 2/21 0.1007928450844332 0.9999953328203589 0 0 3.9942546424540883 9.165567826194579 PTPRD;LRFN1 Negative Regulation Of NMDA Receptor-Mediated Neuronal Transmission R-HSA-9617324 2/21 0.1007928450844332 0.9999953328203589 0 0 3.9942546424540883 9.165567826194579 ACTN2;PPM1E Nitric Oxide Stimulates Guanylate Cyclase R-HSA-392154 2/21 0.1007928450844332 0.9999953328203589 0 0 3.9942546424540883 9.165567826194579 PDE1A;KCNMB1 Platelet Degranulation R-HSA-114608 6/125 0.1042181153060964 0.9999953328203589 0 0 1.9183437618662396 4.337891881389261 TF;ACTN2;SELENOP;FN1;A1BG;THBS1 Dopamine Neurotransmitter Release Cycle R-HSA-212676 2/23 0.11748930704276556 0.9999953328203589 0 0 3.613478139793929 7.737930828101555 APBA1;CPLX1 Response To Elevated Platelet Cytosolic Ca2+ R-HSA-76005 6/130 0.11956152899503877 0.9999953328203589 0 0 1.8405158755307687 3.909116122261993 TF;ACTN2;SELENOP;FN1;A1BG;THBS1 Acetylcholine Inhibits Contraction Of Outer Hair Cells R-HSA-9667769 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 KCNMB1 Signaling By MST1 R-HSA-8852405 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 SPINT1 Ficolins Bind To Repetitive Carbohydrate Structures On Target Cell Surface R-HSA-2855086 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 MASP1 Fructose Catabolism R-HSA-70350 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 ALDH1A1 Toxicity Of Botulinum Toxin Type D (botD) R-HSA-5250955 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 SV2C Toxicity Of Botulinum Toxin Type F (botF) R-HSA-5250981 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 SV2C IRF3 Mediated Activation Of Type 1 IFN R-HSA-1606341 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 DTX4 tRNA Processing In Mitochondrion R-HSA-6785470 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 PRORP MECP2 Regulates Transcription Factors R-HSA-9022707 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 MEF2C Melanin Biosynthesis R-HSA-5662702 1/5 0.12229918904522404 0.9999953328203589 0 0 9.475194552529183 19.910082926776948 DCT Activation Of NMDA Receptors And Postsynaptic Events R-HSA-442755 4/74 0.12341057396864086 0.9999953328203589 0 0 2.1710930947721554 4.5424445222310625 ACTN2;RASGRF2;APBA1;PPM1E RHO GTPases Activate NADPH Oxidases R-HSA-5668599 2/24 0.12608006640494018 0.9999953328203589 0 0 3.449051922736133 7.14242822078945 NOX3;CYBB Sensory Processing Of Sound R-HSA-9659379 4/75 0.12787999161059643 0.9999953328203589 0 0 2.140404068245087 4.402089895861011 KCNMB1;PCDH15;LHFPL5;XIRP2 Netrin-1 Signaling R-HSA-373752 3/49 0.13175810818677902 0.9999953328203589 0 0 2.4760954483695654 5.01851943043664 ABLIM2;SLIT2;NTN1 Assembly And Cell Surface Presentation Of NMDA Receptors R-HSA-9609736 2/25 0.13481412785089741 0.9999953328203589 0 0 3.2989236375964066 6.610575446219755 ACTN2;APBA1 Proton-coupled Monocarboxylate Transport R-HSA-433692 1/6 0.14490560312420964 0.9999953328203589 0 0 7.57976653696498 14.641628557976741 EMB RUNX3 Regulates Immune Response And Cell Migration R-HSA-8949275 1/6 0.14490560312420964 0.9999953328203589 0 0 7.57976653696498 14.641628557976741 ITGA4 Fibronectin Matrix Formation R-HSA-1566977 1/6 0.14490560312420964 0.9999953328203589 0 0 7.57976653696498 14.641628557976741 FN1 Lipid Particle Organization R-HSA-8964572 1/6 0.14490560312420964 0.9999953328203589 0 0 7.57976653696498 14.641628557976741 FITM1 MET Receptor Activation R-HSA-6806942 1/6 0.14490560312420964 0.9999953328203589 0 0 7.57976653696498 14.641628557976741 SPINT1 CREB1 Phosphorylation Thru NMDA Receptor-Mediated Activation Of RAS Signaling R-HSA-442742 2/27 0.1526605807153397 0.9999953328203589 0 0 3.0346978557504873 5.703830692950857 ACTN2;RASGRF2 Nuclear Receptor Transcription Pathway R-HSA-383280 3/53 0.15583722951665926 0.9999953328203589 0 0 2.2775390625 4.233815791659843 THRB;NR1I3;AREG Phase 1 - Inactivation Of Fast Na+ Channels R-HSA-5576894 1/7 0.16693085997363868 0.9999953328203589 0 0 6.316147859922179 11.307013560134054 KCND2 Anchoring Fibril Formation R-HSA-2214320 1/7 0.16693085997363868 0.9999953328203589 0 0 6.316147859922179 11.307013560134054 TLL1 Fructose Metabolism R-HSA-5652084 1/7 0.16693085997363868 0.9999953328203589 0 0 6.316147859922179 11.307013560134054 ALDH1A1 TYSND1 Cleaves Peroxisomal Proteins R-HSA-9033500 1/7 0.16693085997363868 0.9999953328203589 0 0 6.316147859922179 11.307013560134054 SYCP2 Terminal Pathway Of Complement R-HSA-166665 1/7 0.16693085997363868 0.9999953328203589 0 0 6.316147859922179 11.307013560134054 C5 Inactivation Of CDC42 And RAC1 R-HSA-428543 1/7 0.16693085997363868 0.9999953328203589 0 0 6.316147859922179 11.307013560134054 SLIT2 Peroxisomal Lipid Metabolism R-HSA-390918 2/29 0.1709311293667348 0.9999953328203589 0 0 2.8096166341780378 4.96317248829341 ACOXL;SYCP2 SUMOylation Of Intracellular Receptors R-HSA-4090294 2/29 0.1709311293667348 0.9999953328203589 0 0 2.8096166341780378 4.96317248829341 THRB;AREG FOXO-mediated Transcription Of Oxidative Stress, Metabolic And Neuronal Genes R-HSA-9615017 2/29 0.1709311293667348 0.9999953328203589 0 0 2.8096166341780378 4.96317248829341 FOXO1;PLXNA4 Uptake And Actions Of Bacterial Toxins R-HSA-5339562 2/29 0.1709311293667348 0.9999953328203589 0 0 2.8096166341780378 4.96317248829341 SV2C;SYT2 Transmission Across Chemical Synapses R-HSA-112315 9/246 0.18545081695095011 0.9999953328203589 0 0 1.4445389503177064 2.4339983955501205 CACNB4;ACTN2;GABRA5;RASGRF2;APBA1;AKAP5;GABRG3;CPLX1;PPM1E Phosphate Bond Hydrolysis By NTPDase Proteins R-HSA-8850843 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 ENTPD8 Ca2+ Activated K+ Channels R-HSA-1296052 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 KCNMB1 Cross-presentation Of Particulate Exogenous Antigens (Phagosomes) R-HSA-1236973 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 CYBB Regulation Of Gene Expression In Early Pancreatic Precursor Cells R-HSA-210747 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 ONECUT3 Role Of ABL In ROBO-SLIT Signaling R-HSA-428890 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 SLIT2 Sema4D Mediated Inhibition Of Cell Attachment And Migration R-HSA-416550 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 SEMA4D Synthesis Of Epoxy (EET) And Dihydroxyeicosatrienoic Acids (DHET) R-HSA-2142670 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 CYP1A1 Transport Of Fatty Acids R-HSA-804914 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 LCN1 Inhibition Of Signaling By Overexpressed EGFR R-HSA-5638303 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 AREG Netrin Mediated Repulsion Signals R-HSA-418886 1/8 0.18838987083243047 0.9999953328203589 0 0 5.4135630906058925 9.036545161381305 NTN1 EGFR Downregulation R-HSA-182971 2/31 0.18953677249097292 0.9999953328203589 0 0 2.615581098339719 4.350161830287265 AREG;SH3GL2 Neurotransmitter Receptors And Postsynaptic Signal Transmission R-HSA-112314 7/182 0.19037765550905367 0.9999953328203589 0 0 1.520472440944882 2.522076848227824 ACTN2;GABRA5;RASGRF2;APBA1;AKAP5;GABRG3;PPM1E Opsins R-HSA-419771 1/9 0.20929716529846745 0.9999953328203589 0 0 4.736624513618677 7.40808165510879 RRH Phase 3 - Rapid Repolarisation R-HSA-5576890 1/9 0.20929716529846745 0.9999953328203589 0 0 4.736624513618677 7.40808165510879 KCNE1 CHL1 Interactions R-HSA-447041 1/9 0.20929716529846745 0.9999953328203589 0 0 4.736624513618677 7.40808165510879 CHL1 EGFR Interacts With Phospholipase C-gamma R-HSA-212718 1/9 0.20929716529846745 0.9999953328203589 0 0 4.736624513618677 7.40808165510879 AREG Synthesis Of (16-20)-Hydroxyeicosatetraenoic Acids (HETE) R-HSA-2142816 1/9 0.20929716529846745 0.9999953328203589 0 0 4.736624513618677 7.40808165510879 CYP1A1 tRNA Modification In Mitochondrion R-HSA-6787450 1/9 0.20929716529846745 0.9999953328203589 0 0 4.736624513618677 7.40808165510879 PRORP Peroxisomal Protein Import R-HSA-9033241 3/63 0.22093255734843148 0.9999953328203589 0 0 1.89697265625 2.86423482972307 SYCP2;ZNF260;PIPOX AKT Phosphorylates Targets In Nucleus R-HSA-198693 1/10 0.22966690098535653 0.9999953328203589 0 0 4.21011673151751 6.193609140252348 FOXO1 Bicarbonate Transporters R-HSA-425381 1/10 0.22966690098535653 0.9999953328203589 0 0 4.21011673151751 6.193609140252348 SLC4A4 Regulation Of FOXO Transcriptional Activity By Acetylation R-HSA-9617629 1/10 0.22966690098535653 0.9999953328203589 0 0 4.21011673151751 6.193609140252348 FOXO1 Crosslinking Of Collagen Fibrils R-HSA-2243919 1/10 0.22966690098535653 0.9999953328203589 0 0 4.21011673151751 6.193609140252348 TLL1 Role Of Second Messengers In Netrin-1 Signaling R-HSA-418890 1/10 0.22966690098535653 0.9999953328203589 0 0 4.21011673151751 6.193609140252348 NTN1 Sodium/Calcium Exchangers R-HSA-425561 1/10 0.22966690098535653 0.9999953328203589 0 0 4.21011673151751 6.193609140252348 SLC24A3 rRNA Processing In Mitochondrion R-HSA-8868766 1/10 0.22966690098535653 0.9999953328203589 0 0 4.21011673151751 6.193609140252348 PRORP Defective B3GALTL Causes PpS R-HSA-5083635 2/37 0.24658968337801995 0.9999953328203589 0 0 2.1665274296853245 3.033202367365506 THBS1;ADAMTS20 Activation Of Phototransduction Cascade R-HSA-2485179 1/11 0.24951287294218058 0.9999953328203589 0 0 3.7889105058365757 5.259935194342887 PDE6A RHO GTPases Activate IQGAPs R-HSA-5626467 1/11 0.24951287294218058 0.9999953328203589 0 0 3.7889105058365757 5.259935194342887 IQGAP2 DSCAM Interactions R-HSA-376172 1/11 0.24951287294218058 0.9999953328203589 0 0 3.7889105058365757 5.259935194342887 NTN1 Serotonin Receptors R-HSA-390666 1/11 0.24951287294218058 0.9999953328203589 0 0 3.7889105058365757 5.259935194342887 HTR5A Ethanol Oxidation R-HSA-71384 1/11 0.24951287294218058 0.9999953328203589 0 0 3.7889105058365757 5.259935194342887 ALDH1A1 O-glycosylation Of TSR Domain-Containing Proteins R-HSA-5173214 2/38 0.25618967930785974 0.9999953328203589 0 0 2.1062378167641325 2.8683529562865244 THBS1;ADAMTS20 Cell Surface Interactions At Vascular Wall R-HSA-202733 5/134 0.263510774384518 0.9999953328203589 0 0 1.4710442316461467 1.961874353872587 ITGAM;ITGA4;SELENOP;FN1;MERTK Potassium Channels R-HSA-1296071 4/102 0.2684632901626604 0.9999953328203589 0 0 1.5485442709373378 2.0363993557338085 KCNH5;KCND2;KCNMB1;KCNK2 ALK Mutants Bind TKIs R-HSA-9700645 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 FN1 Activation Of RAC1 R-HSA-428540 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 SLIT2 Presynaptic Depolarization And Calcium Channel Opening R-HSA-112308 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 CACNB4 Regulation Of Localization Of FOXO Transcription Factors R-HSA-9614399 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 FOXO1 GRB2 Events In EGFR Signaling R-HSA-179812 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 AREG Tandem Pore Domain Potassium Channels R-HSA-1296346 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 KCNK2 Glutathione Synthesis And Recycling R-HSA-174403 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 OPLAH Interleukin-35 Signaling R-HSA-8984722 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 IL12A Lysine Catabolism R-HSA-71064 1/12 0.268848523000666 0.9999953328203589 0 0 3.444287230279448 4.524440399542772 PIPOX Cargo Recognition For Clathrin-Mediated Endocytosis R-HSA-8856825 4/104 0.2799167243285428 0.9999953328203589 0 0 1.5174168297455968 1.9320709069535433 TF;SYT2;AREG;SH3GL2 Binding And Uptake Of Ligands By Scavenger Receptors R-HSA-2173782 2/41 0.2849998414561692 0.9999953328203589 0 0 1.9439196281301545 2.4401374892069154 MARCO;MASP1 Regulation Of Beta-Cell Development R-HSA-186712 2/41 0.2849998414561692 0.9999953328203589 0 0 1.9439196281301545 2.4401374892069154 ONECUT3;FOXO1 SHC1 Events In EGFR Signaling R-HSA-180336 1/13 0.2876869486382281 0.9999953328203589 0 0 3.157101167315175 3.9333766970928896 AREG Alpha-Linolenic (Omega3) And Linoleic (Omega6) Acid Metabolism R-HSA-2046104 1/13 0.2876869486382281 0.9999953328203589 0 0 3.157101167315175 3.9333766970928896 SYCP2 Post-translational Protein Phosphorylation R-HSA-8957275 4/106 0.29144490407064577 0.9999953328203589 0 0 1.4875100725221595 1.8339575637983418 C4A;TF;FN1;SCG2 Interleukin-4 And Interleukin-13 Signaling R-HSA-6785807 4/107 0.2972330848603084 0.9999953328203589 0 0 1.4729922292098114 1.787091104308292 ITGAM;FN1;IL12A;FOXO1 Clathrin-mediated Endocytosis R-HSA-8856828 5/142 0.30326027374414694 0.9999953328203589 0 0 1.3845713467868899 1.6520204828002045 TF;SYT2;ARPC1A;AREG;SH3GL2 Voltage Gated Potassium Channels R-HSA-1296072 2/43 0.30415258724047134 0.9999953328203589 0 0 1.8489041030761184 2.200613313048407 KCNH5;KCND2 Physiological Factors R-HSA-5578768 1/14 0.3060409118747157 0.9999953328203589 0 0 2.9140975755761747 3.4503978562469304 CORIN Repression Of WNT Target Genes R-HSA-4641265 1/14 0.3060409118747157 0.9999953328203589 0 0 2.9140975755761747 3.4503978562469304 TLE2 Response To Metal Ions R-HSA-5660526 1/14 0.3060409118747157 0.9999953328203589 0 0 2.9140975755761747 3.4503978562469304 SNCB Retrograde Neurotrophin Signaling R-HSA-177504 1/14 0.3060409118747157 0.9999953328203589 0 0 2.9140975755761747 3.4503978562469304 SH3GL2 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion R-HSA-399955 1/14 0.3060409118747157 0.9999953328203589 0 0 2.9140975755761747 3.4503978562469304 PLXNA4 Regulation Of Complement Cascade R-HSA-977606 2/45 0.3232096539739941 0.9999953328203589 0 0 1.7627272315154812 1.9909194685195022 C4A;C5 Phase 2 - Plateau Phase R-HSA-5576893 1/15 0.3239228478910958 0.9999953328203589 0 0 2.705808782657032 3.050122721172833 KCNE1 Regulation Of Innate Immune Responses To Cytosolic DNA R-HSA-3134975 1/15 0.3239228478910958 0.9999953328203589 0 0 2.705808782657032 3.050122721172833 DTX4 GRB2:SOS Provides Linkage To MAPK Signaling For Integrins R-HSA-354194 1/15 0.3239228478910958 0.9999953328203589 0 0 2.705808782657032 3.050122721172833 FN1 InlB-mediated Entry Of Listeria Monocytogenes Into Host Cell R-HSA-8875360 1/15 0.3239228478910958 0.9999953328203589 0 0 2.705808782657032 3.050122721172833 SH3GL2 p130Cas Linkage To MAPK Signaling For Integrins R-HSA-372708 1/15 0.3239228478910958 0.9999953328203589 0 0 2.705808782657032 3.050122721172833 FN1 Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists R-HSA-3772470 1/15 0.3239228478910958 0.9999953328203589 0 0 2.705808782657032 3.050122721172833 SFRP2 Class A/1 (Rhodopsin-like Receptors) R-HSA-373076 10/327 0.33504435334346255 0.9999953328203589 0 0 1.1973639004278978 1.3093082747201708 C5;CXCL11;KEL;XCR1;EDN2;GPR183;NPY2R;RRH;PCDHA4;HTR5A Processing Of SMDT1 R-HSA-8949664 1/16 0.34134487311034 0.9999953328203589 0 0 2.5252918287937742 2.714340111239304 PARL CRMPs In Sema3A Signaling R-HSA-399956 1/16 0.34134487311034 0.9999953328203589 0 0 2.5252918287937742 2.714340111239304 PLXNA4 Regulation Of Gene Expression In Late Stage (Branching Morphogenesis) Pancreatic Bud Precursor Cells R-HSA-210744 1/16 0.34134487311034 0.9999953328203589 0 0 2.5252918287937742 2.714340111239304 ONECUT3 Sema3A PAK Dependent Axon Repulsion R-HSA-399954 1/16 0.34134487311034 0.9999953328203589 0 0 2.5252918287937742 2.714340111239304 PLXNA4 FOXO-mediated Transcription Of Cell Death Genes R-HSA-9614657 1/16 0.34134487311034 0.9999953328203589 0 0 2.5252918287937742 2.714340111239304 FOXO1 Retrograde Transport At Trans-Golgi-Network R-HSA-6811440 2/48 0.3515301508693005 0.9999953328203589 0 0 1.6475125010594118 1.7224080794560823 NAPSA;RAB6B Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 1/17 0.35831879369323594 0.9999953328203589 0 0 2.3673394941634243 2.4296767598359934 CPLX1 Biosynthesis Of DHA-derived SPMs R-HSA-9018677 1/17 0.35831879369323594 0.9999953328203589 0 0 2.3673394941634243 2.4296767598359934 CYP1A1 FOXO-mediated Transcription Of Cell Cycle Genes R-HSA-9617828 1/17 0.35831879369323594 0.9999953328203589 0 0 2.3673394941634243 2.4296767598359934 FOXO1 Synthesis Of PIPs At Golgi Membrane R-HSA-1660514 1/17 0.35831879369323594 0.9999953328203589 0 0 2.3673394941634243 2.4296767598359934 PIK3C2G GAB1 Signalosome R-HSA-180292 1/17 0.35831879369323594 0.9999953328203589 0 0 2.3673394941634243 2.4296767598359934 AREG TNF Receptor Superfamily (TNFSF) Members Mediating Non-Canonical NF-kB Pathway R-HSA-5676594 1/17 0.35831879369323594 0.9999953328203589 0 0 2.3673394941634243 2.4296767598359934 TNFRSF11A Signaling By EGFR R-HSA-177929 2/49 0.36088215101602145 0.9999953328203589 0 0 1.6123760938990501 1.6433398829262225 AREG;SH3GL2 EPH-ephrin Mediated Repulsion Of Cells R-HSA-3928665 2/49 0.36088215101602145 0.9999953328203589 0 0 1.6123760938990501 1.6433398829262225 EPHA7;EPHB1 Neurotransmitter Release Cycle R-HSA-112310 2/50 0.3701835067379452 0.9999953328203589 0 0 1.5787037037037037 1.5688469599937915 APBA1;CPLX1 Serotonin Neurotransmitter Release Cycle R-HSA-181429 1/18 0.37485611328276824 0.9999953328203589 0 0 2.2279697871366446 2.186112973454005 CPLX1 Ephrin Signaling R-HSA-3928664 1/18 0.37485611328276824 0.9999953328203589 0 0 2.2279697871366446 2.186112973454005 EPHB1 Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 1/18 0.37485611328276824 0.9999953328203589 0 0 2.2279697871366446 2.186112973454005 CPLX1 Regulation Of IGF Transport And Uptake By IGFBPs R-HSA-381426 4/123 0.3907573161743172 0.9999953328203589 0 0 1.2738903780690358 1.1970347708410147 C4A;TF;FN1;SCG2 Phase 4 - Resting Membrane Potential R-HSA-5576886 1/19 0.3909680407652018 0.9999953328203589 0 0 2.1040856031128405 1.976008775215887 KCNK2 Biosynthesis Of Specialized Proresolving Mediators (SPMs) R-HSA-9018678 1/19 0.3909680407652018 0.9999953328203589 0 0 2.1040856031128405 1.976008775215887 CYP1A1 GABA Synthesis, Release, Reuptake And Degradation R-HSA-888590 1/19 0.3909680407652018 0.9999953328203589 0 0 2.1040856031128405 1.976008775215887 CPLX1 Listeria Monocytogenes Entry Into Host Cells R-HSA-8876384 1/19 0.3909680407652018 0.9999953328203589 0 0 2.1040856031128405 1.976008775215887 SH3GL2 Nuclear Events Stimulated By ALK Signaling In Cancer R-HSA-9725371 1/19 0.3909680407652018 0.9999953328203589 0 0 2.1040856031128405 1.976008775215887 FN1 Peptide Ligand-Binding Receptors R-HSA-375276 6/196 0.3924001363866002 0.9999953328203589 0 0 1.1970840657636233 1.119840066122841 C5;CXCL11;KEL;XCR1;EDN2;NPY2R Muscle Contraction R-HSA-397014 6/196 0.3924001363866002 0.9999953328203589 0 0 1.1970840657636233 1.119840066122841 KCNE1;KCND2;CAV3;ACTN2;KCNK2;CORIN Receptor-type Tyrosine-Protein Phosphatases R-HSA-388844 1/20 0.4066654978228012 0.9999953328203589 0 0 1.9932418595125947 1.7934478746937177 PTPRD Chondroitin Sulfate Biosynthesis R-HSA-2022870 1/20 0.4066654978228012 0.9999953328203589 0 0 1.9932418595125947 1.7934478746937177 CHSY3 Regulation Of Gene Expression In Beta Cells R-HSA-210745 1/20 0.4066654978228012 0.9999953328203589 0 0 1.9932418595125947 1.7934478746937177 FOXO1 Sema4D Induced Cell Migration And Growth-Cone Collapse R-HSA-416572 1/20 0.4066654978228012 0.9999953328203589 0 0 1.9932418595125947 1.7934478746937177 SEMA4D Syndecan Interactions R-HSA-3000170 1/20 0.4066654978228012 0.9999953328203589 0 0 1.9932418595125947 1.7934478746937177 THBS1 TP53 Regulates Transcription Of Genes Involved In Cytochrome C Release R-HSA-6803204 1/20 0.4066654978228012 0.9999953328203589 0 0 1.9932418595125947 1.7934478746937177 TP53AIP1 Cardiac Conduction R-HSA-5576891 4/126 0.4082265717245973 0.9999953328203589 0 0 1.2423727182316897 1.1130826368755073 KCNE1;KCND2;KCNK2;CORIN G Alpha (I) Signaling Events R-HSA-418594 9/312 0.4122578742778016 0.9999953328203589 0 0 1.126012601260126 0.9977667663860577 C5;CXCL11;GNAT2;PDE1A;GPR183;NPY2R;RRH;PCDHA4;HTR5A Golgi Associated Vesicle Biogenesis R-HSA-432722 2/55 0.41581237533717247 0.9999953328203589 0 0 1.429401596233771 1.2543301200823211 NAPSA;SH3GL2 EPH-Ephrin Signaling R-HSA-2682334 3/91 0.41676361668253303 0.9999953328203589 0 0 1.2915261008522727 1.1303902473866074 EPHA7;ARPC1A;EPHB1 Cellular Hexose Transport R-HSA-189200 1/21 0.4219591261776555 0.9999953328203589 0 0 1.8934824902723735 1.6337853587797915 SLC2A4 Unblocking Of NMDA Receptors, Glutamate Binding And Activation R-HSA-438066 1/21 0.4219591261776555 0.9999953328203589 0 0 1.8934824902723735 1.6337853587797915 ACTN2 ZBP1(DAI) Mediated Induction Of Type I IFNs R-HSA-1606322 1/21 0.4219591261776555 0.9999953328203589 0 0 1.8934824902723735 1.6337853587797915 DTX4 Negative Regulation Of MET Activity R-HSA-6807004 1/21 0.4219591261776555 0.9999953328203589 0 0 1.8934824902723735 1.6337853587797915 SH3GL2 Chemokine Receptors Bind Chemokines R-HSA-380108 2/56 0.42474177466032004 0.9999953328203589 0 0 1.4028589993502274 1.2012315237262474 CXCL11;XCR1 E3 Ubiquitin Ligases Ubiquitinate Target Proteins R-HSA-8866654 2/56 0.42474177466032004 0.9999953328203589 0 0 1.4028589993502274 1.2012315237262474 PRKDC;RNF152 RA Biosynthesis Pathway R-HSA-5365859 1/22 0.43685929495999504 0.9999953328203589 0 0 1.803224013340745 1.4933293550889355 ALDH1A1 ERK/MAPK Targets R-HSA-198753 1/22 0.43685929495999504 0.9999953328203589 0 0 1.803224013340745 1.4933293550889355 MEF2C Mitochondrial Calcium Ion Transport R-HSA-8949215 1/22 0.43685929495999504 0.9999953328203589 0 0 1.803224013340745 1.4933293550889355 PARL Nephrin Family Interactions R-HSA-373753 1/22 0.43685929495999504 0.9999953328203589 0 0 1.803224013340745 1.4933293550889355 ACTN2 GABA Receptor Activation R-HSA-977443 2/59 0.4510921375999099 0.9999953328203589 0 0 1.3288191238329743 1.05785119704663 GABRA5;GABRG3 RHOBTB1 GTPase Cycle R-HSA-9013422 1/23 0.45137610747387397 0.9999953328203589 0 0 1.7211708524938096 1.3691128345346204 RHOBTB1 Glutamate Neurotransmitter Release Cycle R-HSA-210500 1/23 0.45137610747387397 0.9999953328203589 0 0 1.7211708524938096 1.3691128345346204 CPLX1 Long-term Potentiation R-HSA-9620244 1/23 0.45137610747387397 0.9999953328203589 0 0 1.7211708524938096 1.3691128345346204 ACTN2 SLC-mediated Transmembrane Transport R-HSA-425407 7/247 0.45243550787287645 0.9999953328203589 0 0 1.1049458661417322 0.8763436711844136 SLC47A2;SLC24A3;LCN1;EMB;SLC2A4;SLC4A4;SLC7A2 RUNX2 Regulates Osteoblast Differentiation R-HSA-8940973 1/24 0.465519408163018 0.9999953328203589 0 0 1.6462527491118255 1.2587273048554186 AREG Sema4D In Semaphorin Signaling R-HSA-400685 1/24 0.465519408163018 0.9999953328203589 0 0 1.6462527491118255 1.2587273048554186 SEMA4D Signaling By EGFR In Cancer R-HSA-1643713 1/24 0.465519408163018 0.9999953328203589 0 0 1.6462527491118255 1.2587273048554186 AREG Estrogen-dependent Nuclear Events Downstream Of ESR-membrane Signaling R-HSA-9634638 1/24 0.465519408163018 0.9999953328203589 0 0 1.6462527491118255 1.2587273048554186 AREG Synthesis Of Bile Acids And Bile Salts Via 7Alpha-Hydroxycholesterol R-HSA-193368 1/24 0.465519408163018 0.9999953328203589 0 0 1.6462527491118255 1.2587273048554186 SYCP2 Xenobiotics R-HSA-211981 1/24 0.465519408163018 0.9999953328203589 0 0 1.6462527491118255 1.2587273048554186 CYP1A1 Post NMDA Receptor Activation Events R-HSA-438064 2/61 0.4682737615777659 0.9999953328203589 0 0 1.2836422506360061 0.973902191163942 ACTN2;RASGRF2 Ca2+ Pathway R-HSA-4086398 2/61 0.4682737615777659 0.9999953328203589 0 0 1.2836422506360061 0.973902191163942 GNAT2;PDE6A Nuclear Events (Kinase And Transcription Factor Activation) R-HSA-198725 2/61 0.4682737615777659 0.9999953328203589 0 0 1.2836422506360061 0.973902191163942 MEF2C;TF Stimuli-sensing Channels R-HSA-2672351 3/100 0.4775201323476977 0.9999953328203589 0 0 1.1711501288659794 0.8656543973723753 ANO1;TRPA1;CLCA2 Deadenylation Of mRNA R-HSA-429947 1/25 0.4792987890723534 0.9999953328203589 0 0 1.577577821011673 1.1601997910907125 EIF4A1 TRP Channels R-HSA-3295583 1/25 0.4792987890723534 0.9999953328203589 0 0 1.577577821011673 1.1601997910907125 TRPA1 Interleukin-7 Signaling R-HSA-1266695 1/25 0.4792987890723534 0.9999953328203589 0 0 1.577577821011673 1.1601997910907125 RAG1 Cytosolic Sensors Of Pathogen-Associated DNA R-HSA-1834949 2/63 0.48513090276372434 0.9999953328203589 0 0 1.2414277953535935 0.8979700636266693 PRKDC;DTX4 Signaling By MET R-HSA-6806834 2/63 0.48513090276372434 0.9999953328203589 0 0 1.2414277953535935 0.8979700636266693 SPINT1;SH3GL2 RAC1 GTPase Cycle R-HSA-9013149 5/178 0.4855713129404359 0.9999953328203589 0 0 1.094412331406551 0.79063533363761 PLEKHG3;RASGRF2;NOX3;CYBB;IQGAP2 Biological Oxidations R-HSA-211859 6/218 0.4923357264316061 0.9999953328203589 0 0 1.0716350965637396 0.7593546544196113 GSTM3;AKR7A3;ALDH1A1;CYP1A1;MGST2;OPLAH Constitutive Signaling By AKT1 E17K In Cancer R-HSA-5674400 1/26 0.49272359650904834 0.9999953328203589 0 0 1.514396887159533 1.0719005938352106 FOXO1 Synthesis Of IP3 And IP4 In Cytosol R-HSA-1855204 1/26 0.49272359650904834 0.9999953328203589 0 0 1.514396887159533 1.0719005938352106 ITPKB WNT Ligand Biogenesis And Trafficking R-HSA-3238698 1/26 0.49272359650904834 0.9999953328203589 0 0 1.514396887159533 1.0719005938352106 WNT9B Interleukin-20 Family Signaling R-HSA-8854691 1/26 0.49272359650904834 0.9999953328203589 0 0 1.514396887159533 1.0719005938352106 IL19 Semaphorin Interactions R-HSA-373755 2/64 0.4934341327544088 0.9999953328203589 0 0 1.221341885178897 0.8627142582373414 SEMA4D;PLXNA4 FOXO-mediated Transcription R-HSA-9614085 2/65 0.501652106949722 0.9999953328203589 0 0 1.2018936229462545 0.8291244090814178 FOXO1;PLXNA4 Transport Of Inorganic Cations/Anions And Amino Acids/Oligopeptides R-HSA-425393 3/104 0.503573510291673 0.9999953328203589 0 0 1.124535891089109 0.7714603856637087 SLC24A3;SLC4A4;SLC7A2 Acyl Chain Remodelling Of PC R-HSA-1482788 1/27 0.5058029369452168 0.9999953328203589 0 0 1.456076025142173 0.9924732686163085 PLB1 Insulin Processing R-HSA-264876 1/27 0.5058029369452168 0.9999953328203589 0 0 1.456076025142173 0.9924732686163085 PCSK2 Integrin Signaling R-HSA-354192 1/27 0.5058029369452168 0.9999953328203589 0 0 1.456076025142173 0.9924732686163085 FN1 COPII-mediated Vesicle Transport R-HSA-204005 2/66 0.5097837041654063 0.9999953328203589 0 0 1.1830531189083822 0.7971042243085579 NAPSA;AREG Collagen Biosynthesis And Modifying Enzymes R-HSA-1650814 2/67 0.5178279172699174 0.9999953328203589 0 0 1.1647923226870596 0.7665641521273423 COL20A1;TLL1 Recycling Pathway Of L1 R-HSA-437239 1/28 0.5185456836625597 0.9999953328203589 0 0 1.4020752269779506 0.9207808648713646 SH3GL2 Molecules Associated With Elastic Fibres R-HSA-2129379 1/28 0.5185456836625597 0.9999953328203589 0 0 1.4020752269779506 0.9207808648713646 FBLN1 Phase II - Conjugation Of Compounds R-HSA-156580 3/107 0.5226681388740528 0.9999953328203589 0 0 1.0919283353365385 0.7084524399760472 GSTM3;MGST2;OPLAH Surfactant Metabolism R-HSA-5683826 1/29 0.530960482417512 0.9999953328203589 0 0 1.3519316286826015 0.8558642218097373 NAPSA Myogenesis R-HSA-525793 1/29 0.530960482417512 0.9999953328203589 0 0 1.3519316286826015 0.8558642218097373 MEF2C Diseases Associated With O-glycosylation Of Proteins R-HSA-3906995 2/69 0.5336507016702835 0.9999953328203589 0 0 1.1299060254284135 0.709596543647232 THBS1;ADAMTS20 Tight Junction Interactions R-HSA-420029 1/30 0.5430557572657055 0.9999953328203589 0 0 1.3052462095800348 0.7969093027736572 CLDN19 HS-GAG Biosynthesis R-HSA-2022928 1/30 0.5430557572657055 0.9999953328203589 0 0 1.3052462095800348 0.7969093027736572 HS3ST5 MAPK Targets/ Nuclear Events Mediated By MAP Kinases R-HSA-450282 1/30 0.5430557572657055 0.9999953328203589 0 0 1.3052462095800348 0.7969093027736572 MEF2C trans-Golgi Network Vesicle Budding R-HSA-199992 2/71 0.5491144920191648 0.9999953328203589 0 0 1.097042122213747 0.6576200491574078 NAPSA;SH3GL2 Golgi-to-ER Retrograde Transport R-HSA-8856688 3/112 0.5535754160827342 0.9999953328203589 0 0 1.041571100917431 0.6159406563208029 NAPSA;KIF12;RAB6B Activated NOTCH1 Transmits Signal To Nucleus R-HSA-2122948 1/31 0.5548397163699581 0.9999953328203589 0 0 1.2616731517509727 0.7432213814637467 DTX4 RUNX2 Regulates Bone Development R-HSA-8941326 1/31 0.5548397163699581 0.9999953328203589 0 0 1.2616731517509727 0.7432213814637467 AREG Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity R-HSA-399721 1/31 0.5548397163699581 0.9999953328203589 0 0 1.2616731517509727 0.7432213814637467 AKAP5 Transferrin Endocytosis And Recycling R-HSA-917977 1/31 0.5548397163699581 0.9999953328203589 0 0 1.2616731517509727 0.7432213814637467 TF Signaling By NTRK1 (TRKA) R-HSA-187037 3/114 0.5656007978278288 0.9999953328203589 0 0 1.0226984797297298 0.5828018627741803 MEF2C;TF;SH3GL2 Activation Of Pre-Replicative Complex R-HSA-68962 1/32 0.5663203571867709 0.9999953328203589 0 0 1.2209112589431406 0.6942044753429032 RPA4 Cargo Concentration In ER R-HSA-5694530 1/32 0.5663203571867709 0.9999953328203589 0 0 1.2209112589431406 0.6942044753429032 AREG Inactivation, Recovery And Regulation Of Phototransduction Cascade R-HSA-2514859 1/32 0.5663203571867709 0.9999953328203589 0 0 1.2209112589431406 0.6942044753429032 PDE6A RHOG GTPase Cycle R-HSA-9013408 2/74 0.5716277038564623 0.9999953328203589 0 0 1.0511695906432748 0.5878848491162952 PLEKHG3;IQGAP2 Signaling By NOTCH1 R-HSA-1980143 2/74 0.5716277038564623 0.9999953328203589 0 0 1.0511695906432748 0.5878848491162952 TLE2;DTX4 Amino Acid Transport Across Plasma Membrane R-HSA-352230 1/33 0.577505472508631 0.9999953328203589 0 0 1.1826969844357977 0.6493448305180249 SLC7A2 CaM Pathway R-HSA-111997 1/33 0.577505472508631 0.9999953328203589 0 0 1.1826969844357977 0.6493448305180249 PDE1A Sialic Acid Metabolism R-HSA-4085001 1/33 0.577505472508631 0.9999953328203589 0 0 1.1826969844357977 0.6493448305180249 NPL Signaling By High-Kinase Activity BRAF Mutants R-HSA-6802948 1/33 0.577505472508631 0.9999953328203589 0 0 1.1826969844357977 0.6493448305180249 FN1 Striated Muscle Contraction R-HSA-390522 1/33 0.577505472508631 0.9999953328203589 0 0 1.1826969844357977 0.6493448305180249 ACTN2 Phototransduction Cascade R-HSA-2514856 1/33 0.577505472508631 0.9999953328203589 0 0 1.1826969844357977 0.6493448305180249 PDE6A Axon Guidance R-HSA-422475 13/519 0.5801217033288575 0.9999953328203589 0 0 0.971320252586492 0.5289007436625289 ROBO2;EPHA7;SEMA4D;ARPC1A;AKAP5;NTN1;CACNB4;ABLIM2;CHL1;SLIT2;EPHB1;PLXNA4;SH3GL2 Protein Ubiquitination R-HSA-8852135 2/76 0.5861775061767681 0.9999953328203589 0 0 1.022654233180549 0.546232988715964 PRKDC;RNF152 COPI-independent Golgi-to-ER Retrograde Traffic R-HSA-6811436 1/34 0.5884026549535015 0.9999953328203589 0 0 1.1467987265652635 0.6081975693754755 RAB6B Detoxification Of Reactive Oxygen Species R-HSA-3299685 1/34 0.5884026549535015 0.9999953328203589 0 0 1.1467987265652635 0.6081975693754755 CYBB EPHB-mediated Forward Signaling R-HSA-3928662 1/34 0.5884026549535015 0.9999953328203589 0 0 1.1467987265652635 0.6081975693754755 ARPC1A Synthesis Of Bile Acids And Bile Salts R-HSA-192105 1/34 0.5884026549535015 0.9999953328203589 0 0 1.1467987265652635 0.6081975693754755 SYCP2 Lysosome Vesicle Biogenesis R-HSA-432720 1/34 0.5884026549535015 0.9999953328203589 0 0 1.1467987265652635 0.6081975693754755 SH3GL2 Metabolic Disorders Of Biological Oxidation Enzymes R-HSA-5579029 1/34 0.5884026549535015 0.9999953328203589 0 0 1.1467987265652635 0.6081975693754755 OPLAH Nucleotide Catabolism R-HSA-8956319 1/35 0.5990193025841737 0.9999953328203589 0 0 1.113012130922408 0.5703758179422395 ENTPD8 RHOBTB GTPase Cycle R-HSA-9706574 1/35 0.5990193025841737 0.9999953328203589 0 0 1.113012130922408 0.5703758179422395 RHOBTB1 Ca-dependent Events R-HSA-111996 1/35 0.5990193025841737 0.9999953328203589 0 0 1.113012130922408 0.5703758179422395 PDE1A Impaired BRCA2 Binding To RAD51 R-HSA-9709570 1/35 0.5990193025841737 0.9999953328203589 0 0 1.113012130922408 0.5703758179422395 RAD9B COPI-dependent Golgi-to-ER Retrograde Traffic R-HSA-6811434 2/78 0.6003584778827356 0.9999953328203589 0 0 0.995639684005335 0.5080035822505006 NAPSA;KIF12 Activated PKN1 Stimulates Transcription Of Androgen Receptor Regulated KLK2 And KLK3 R-HSA-5625886 1/36 0.6093626237556488 0.9999953328203589 0 0 1.0811561978877153 0.535541800026014 AREG Activation Of ATR In Response To Replication Stress R-HSA-176187 1/36 0.6093626237556488 0.9999953328203589 0 0 1.0811561978877153 0.535541800026014 RAD9B Platelet Aggregation (Plug Formation) R-HSA-76009 1/36 0.6093626237556488 0.9999953328203589 0 0 1.0811561978877153 0.535541800026014 FN1 RHO GTPases Activate WASPs And WAVEs R-HSA-5663213 1/36 0.6093626237556488 0.9999953328203589 0 0 1.0811561978877153 0.535541800026014 ARPC1A ROS And RNS Production In Phagocytes R-HSA-1222556 1/36 0.6093626237556488 0.9999953328203589 0 0 1.0811561978877153 0.535541800026014 CYBB HDR Thru Single Strand Annealing (SSA) R-HSA-5685938 1/37 0.6194396420241532 0.9999953328203589 0 0 1.0510700389105059 0.5033994978960216 RAD9B MAP2K And MAPK Activation R-HSA-5674135 1/37 0.6194396420241532 0.9999953328203589 0 0 1.0510700389105059 0.5033994978960216 FN1 NCAM1 Interactions R-HSA-419037 1/37 0.6194396420241532 0.9999953328203589 0 0 1.0510700389105059 0.5033994978960216 CACNB4 Extracellular Matrix Organization R-HSA-1474244 7/291 0.6250826689457086 0.9999953328203589 0 0 0.9316222135965398 0.43774260366325446 ITGAM;ITGA4;FN1;COL20A1;FBLN1;TLL1;THBS1 Signaling By RAF1 Mutants R-HSA-9656223 1/38 0.6292572004877964 0.9999953328203589 0 0 1.0226101587969292 0.4736885713397084 FN1 HSP90 Chaperone Cycle For Steroid Hormone Receptors (SHR) In Presence Of Ligand R-HSA-3371497 1/38 0.6292572004877964 0.9999953328203589 0 0 1.0226101587969292 0.4736885713397084 AREG Platelet Homeostasis R-HSA-418346 2/83 0.63419850337744 0.9999953328203589 0 0 0.9339397877409573 0.42530990021688453 PDE1A;KCNMB1 GPCR Ligand Binding R-HSA-500792 11/458 0.6355432278228104 0.9999953328203589 0 0 0.92955683391925 0.42134503091077025 C5;CXCL11;KEL;XCR1;EDN2;GPR183;NPY2R;WNT9B;PCDHA4;RRH;HTR5A DAG And IP3 Signaling R-HSA-1489509 1/39 0.6388219672000787 0.9999953328203589 0 0 0.995648167110383 0.4461792904163594 PDE1A Elastic Fibre Formation R-HSA-1566948 1/39 0.6388219672000787 0.9999953328203589 0 0 0.995648167110383 0.4461792904163594 FBLN1 NGF-stimulated Transcription R-HSA-9031628 1/39 0.6388219672000787 0.9999953328203589 0 0 0.995648167110383 0.4461792904163594 TF Platelet Activation, Signaling And Aggregation R-HSA-76002 6/254 0.641126206284121 0.9999953328203589 0 0 0.9143640281386654 0.4064612829581656 TF;ACTN2;SELENOP;FN1;A1BG;THBS1 Amine Ligand-Binding Receptors R-HSA-375280 1/40 0.6481404387314338 0.9999953328203589 0 0 0.9700688416641724 0.4206682963257204 HTR5A Presynaptic Phase Of Homologous DNA Pairing And Strand Exchange R-HSA-5693616 1/40 0.6481404387314338 0.9999953328203589 0 0 0.9700688416641724 0.4206682963257204 RAD9B Nervous System Development R-HSA-9675108 13/545 0.6502117271229385 0.9999953328203589 0 0 0.9225840996914597 0.39713300069762003 ROBO2;EPHA7;SEMA4D;ARPC1A;AKAP5;NTN1;CACNB4;ABLIM2;CHL1;SLIT2;EPHB1;PLXNA4;SH3GL2 Transport Of Bile Salts And Organic Acids, Metal Ions And Amine Compounds R-HSA-425366 2/86 0.6534045696733871 0.9999953328203589 0 0 0.9004455583402952 0.3831925188061578 SLC47A2;EMB Paradoxical Activation Of RAF Signaling By Kinase Inactive BRAF R-HSA-6802955 1/41 0.6572189453939579 0.9999953328203589 0 0 0.9457684824902723 0.3969750335293306 FN1 Defective Homologous Recombination Repair (HRR) Due To BRCA2 Loss Of Function R-HSA-9701190 1/41 0.6572189453939579 0.9999953328203589 0 0 0.9457684824902723 0.3969750335293306 RAD9B Signaling By Retinoic Acid R-HSA-5362517 1/41 0.6572189453939579 0.9999953328203589 0 0 0.9457684824902723 0.3969750335293306 ALDH1A1 Non-integrin membrane-ECM Interactions R-HSA-3000171 1/41 0.6572189453939579 0.9999953328203589 0 0 0.9457684824902723 0.3969750335293306 THBS1 Ion Channel Transport R-HSA-983712 4/175 0.6631731600209927 0.9999953328203589 0 0 0.8841281285405294 0.36312835025768186 ANO1;TRPA1;CLCA2;ATP11A Signaling By NTRKs R-HSA-166520 3/132 0.6644743669098072 0.9999953328203589 0 0 0.8791787790697675 0.35937221796070773 MEF2C;TF;SH3GL2 Meiosis R-HSA-1500620 2/88 0.6657567622919693 0.9999953328203589 0 0 0.8794142980189492 0.35777290764077324 SYCP2;TEX15 Deactivation Of Beta-Catenin Transactivating Complex R-HSA-3769402 1/42 0.666063654867756 0.9999953328203589 0 0 0.9226535066907089 0.374938737926268 TLE2 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion R-HSA-381676 1/42 0.666063654867756 0.9999953328203589 0 0 0.9226535066907089 0.374938737926268 AKAP5 Intra-Golgi Traffic R-HSA-6811438 1/42 0.666063654867756 0.9999953328203589 0 0 0.9226535066907089 0.374938737926268 NAPSA Kinesins R-HSA-983189 1/42 0.666063654867756 0.9999953328203589 0 0 0.9226535066907089 0.374938737926268 KIF12 RAB GEFs Exchange GTP For GDP On RABs R-HSA-8876198 2/89 0.6717986600174024 0.9999953328203589 0 0 0.8692612757948511 0.3457891769120218 DENND2C;RAB6B Retinoid Metabolism And Transport R-HSA-975634 1/43 0.6746805765717628 0.9999953328203589 0 0 0.900639244024458 0.35441588070683966 PLB1 Smooth Muscle Contraction R-HSA-445355 1/43 0.6746805765717628 0.9999953328203589 0 0 0.900639244024458 0.35441588070683966 CAV3 Homologous DNA Pairing And Strand Exchange R-HSA-5693579 1/43 0.6746805765717628 0.9999953328203589 0 0 0.900639244024458 0.35441588070683966 RAD9B Transport Of Vitamins, Nucleosides, And Related Molecules R-HSA-425397 1/43 0.6746805765717628 0.9999953328203589 0 0 0.900639244024458 0.35441588070683966 LCN1 Collagen Formation R-HSA-1474290 2/90 0.6777517791484936 0.9999953328203589 0 0 0.8593390040758462 0.3342606720143763 COL20A1;TLL1 MAPK6/MAPK4 Signaling R-HSA-5687128 2/90 0.6777517791484936 0.9999953328203589 0 0 0.8593390040758462 0.3342606720143763 FOXO1;RAG1 Collagen Chain Trimerization R-HSA-8948216 1/44 0.6830755659887265 0.9999953328203589 0 0 0.8796489005519862 0.33527799124523744 COL20A1 TP53 Regulates Transcription Of Cell Death Genes R-HSA-5633008 1/44 0.6830755659887265 0.9999953328203589 0 0 0.8796489005519862 0.33527799124523744 TP53AIP1 Interleukin-12 Signaling R-HSA-9020591 1/44 0.6830755659887265 0.9999953328203589 0 0 0.8796489005519862 0.33527799124523744 IL12A Interleukin-2 Family Signaling R-HSA-451927 1/44 0.6830755659887265 0.9999953328203589 0 0 0.8796489005519862 0.33527799124523744 LGALS9 Post-translational Modification: Synthesis Of GPI-anchored Proteins R-HSA-163125 2/92 0.6893939365552434 0.9999953328203589 0 0 0.8401559454191033 0.3124896356738378 IZUMO1R;TECTA Bile Acid And Bile Salt Metabolism R-HSA-194068 1/45 0.6912543280700636 0.9999953328203589 0 0 0.8596126636009904 0.31740979686728943 SYCP2 TBC/RABGAPs R-HSA-8854214 1/45 0.6912543280700636 0.9999953328203589 0 0 0.8596126636009904 0.31740979686728943 RAB6B Glycosphingolipid Metabolism R-HSA-1660662 1/45 0.6912543280700636 0.9999953328203589 0 0 0.8596126636009904 0.31740979686728943 GALC Heme Signaling R-HSA-9707616 1/45 0.6912543280700636 0.9999953328203589 0 0 0.8596126636009904 0.31740979686728943 MEF2C Interleukin-10 Signaling R-HSA-6783783 1/45 0.6912543280700636 0.9999953328203589 0 0 0.8596126636009904 0.31740979686728943 IL12A RAC3 GTPase Cycle R-HSA-9013423 2/93 0.6950841760383364 0.9999953328203589 0 0 0.8308806203543045 0.30220983032600074 NOX3;CYBB Signaling By GPCR R-HSA-372790 16/689 0.6995028689416233 0.9999953328203589 0 0 0.8962709966738827 0.3203141538369996 XCR1;EDN2;RASGRF2;PDE1A;NPY2R;WNT9B;RRH;GPR83;HTR5A;C5;CXCL11;KEL;GNAT2;GPR183;PDE3A;PCDHA4 PLC Beta Mediated Events R-HSA-112043 1/47 0.7069852629673856 0.9999953328203589 0 0 0.8221536119099984 0.28507803051237823 PDE1A Metabolism Of Fat-Soluble Vitamins R-HSA-6806667 1/47 0.7069852629673856 0.9999953328203589 0 0 0.8221536119099984 0.28507803051237823 PLB1 Inositol Phosphate Metabolism R-HSA-1483249 1/48 0.7145481288672565 0.9999953328203589 0 0 0.8046195877142147 0.27043660511586637 ITPKB NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1/48 0.7145481288672565 0.9999953328203589 0 0 0.8046195877142147 0.27043660511586637 TLE2 Visual Phototransduction R-HSA-2187338 2/98 0.7222533245290855 0.9999953328203589 0 0 0.7874025341130604 0.25620451420994284 PDE6A;PLB1 L1CAM Interactions R-HSA-373760 2/99 0.727435707473539 0.9999953328203589 0 0 0.779244790096662 0.24797880340029174 CHL1;SH3GL2 GPCR Downstream Signaling R-HSA-388396 14/619 0.7274817331378333 0.9999953328203589 0 0 0.8720410418831758 0.27745414965279974 XCR1;EDN2;RASGRF2;PDE1A;NPY2R;RRH;GPR83;HTR5A;C5;CXCL11;GNAT2;GPR183;PDE3A;PCDHA4 Chondroitin Sulfate/Dermatan Sulfate Metabolism R-HSA-1793185 1/50 0.7290943698723794 0.9999953328203589 0 0 0.77169856269356 0.24381978470925048 CHSY3 Diseases Of DNA Repair R-HSA-9675135 1/51 0.7360876358926706 0.9999953328203589 0 0 0.7562256809338521 0.23171215922151697 RAD9B Synthesis Of PIPs At Plasma Membrane R-HSA-1660499 1/51 0.7360876358926706 0.9999953328203589 0 0 0.7562256809338521 0.23171215922151697 PIK3C2G Translocation Of SLC2A4 (GLUT4) To Plasma Membrane R-HSA-1445148 1/51 0.7360876358926706 0.9999953328203589 0 0 0.7562256809338521 0.23171215922151697 SLC2A4 Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1/51 0.7360876358926706 0.9999953328203589 0 0 0.7562256809338521 0.23171215922151697 PRKDC CDC42 GTPase Cycle R-HSA-9013148 3/149 0.7418652858582827 0.9999953328203589 0 0 0.7761263912671232 0.23174172247621036 PLEKHG3;RASGRF2;IQGAP2 DNA Double-Strand Break Repair R-HSA-5693532 3/149 0.7418652858582827 0.9999953328203589 0 0 0.7761263912671232 0.23174172247621036 PRKDC;CNKSR3;RAD9B Signaling By PDGF R-HSA-186797 1/52 0.742900715095357 0.9999953328203589 0 0 0.7413595788509957 0.22032678112754694 THBS1 G-protein Mediated Events R-HSA-112040 1/52 0.742900715095357 0.9999953328203589 0 0 0.7413595788509957 0.22032678112754694 PDE1A Transcriptional Activation Of Mitochondrial Biogenesis R-HSA-2151201 1/52 0.742900715095357 0.9999953328203589 0 0 0.7413595788509957 0.22032678112754694 MEF2C Heparan Sulfate/Heparin (HS-GAG) Metabolism R-HSA-1638091 1/53 0.7495382414212483 0.9999953328203589 0 0 0.7270652499251721 0.20961141391852478 HS3ST5 Ion Transport By P-type ATPases R-HSA-936837 1/53 0.7495382414212483 0.9999953328203589 0 0 0.7270652499251721 0.20961141391852478 ATP11A Phase I - Functionalization Of Compounds R-HSA-211945 2/104 0.7521323779408433 0.9999953328203589 0 0 0.7408554064900814 0.21102742915740688 ALDH1A1;CYP1A1 Interleukin-12 Family Signaling R-HSA-447115 1/54 0.7560047297528579 0.9999953328203589 0 0 0.7133103296380588 0.19951835355239864 IL12A PI3K/AKT Signaling In Cancer R-HSA-2219528 2/105 0.7568343136104623 0.9999953328203589 0 0 0.7336247847234051 0.20439587758429253 AREG;FOXO1 G Alpha (S) Signaling Events R-HSA-418555 3/153 0.7578623128424377 0.9999953328203589 0 0 0.7552734375 0.20940224566922644 PDE1A;PDE3A;GPR83 Signaling By ALK Fusions And Activated Point Mutants R-HSA-9725370 1/55 0.7623045791216517 0.9999953328203589 0 0 0.7000648508430609 0.1900039662259301 FN1 O-linked Glycosylation R-HSA-5173105 2/107 0.7660074451497298 0.9999953328203589 0 0 0.7195767195767195 0.19181280957150235 THBS1;ADAMTS20 Deadenylation-dependent mRNA Decay R-HSA-429914 1/56 0.7684420754941439 0.9999953328203589 0 0 0.6873010258224266 0.18102828063379728 EIF4A1 Meiotic Recombination R-HSA-912446 1/56 0.7684420754941439 0.9999953328203589 0 0 0.6873010258224266 0.18102828063379728 TEX15 Assembly Of Collagen Fibrils And Other Multimeric Structures R-HSA-2022090 1/57 0.7744213950798225 0.9999953328203589 0 0 0.6749930516953864 0.172554626675319 TLL1 Ribosomal Scanning And Start Codon Recognition R-HSA-72702 1/57 0.7744213950798225 0.9999953328203589 0 0 0.6749930516953864 0.172554626675319 EIF4A1 Signaling By ERBB4 R-HSA-1236394 1/57 0.7744213950798225 0.9999953328203589 0 0 0.6749930516953864 0.172554626675319 GABRG3 Translation Initiation Complex Formation R-HSA-72649 1/57 0.7744213950798225 0.9999953328203589 0 0 0.6749930516953864 0.172554626675319 EIF4A1 NCAM Signaling For Neurite Out-Growth R-HSA-375165 1/57 0.7744213950798225 0.9999953328203589 0 0 0.6749930516953864 0.172554626675319 CACNB4 NRAGE Signals Death Thru JNK R-HSA-193648 1/57 0.7744213950798225 0.9999953328203589 0 0 0.6749930516953864 0.172554626675319 RASGRF2 mRNA Activation Upon Binding Of Cap-Binding Complex And eIFs, Subsequent Binding To 43S R-HSA-72662 1/58 0.7802466066638484 0.9999953328203589 0 0 0.6631169363096457 0.16454931586937216 EIF4A1 mRNA 3-End Processing R-HSA-72187 1/58 0.7802466066638484 0.9999953328203589 0 0 0.6631169363096457 0.16454931586937216 POLDIP3 Arachidonic Acid Metabolism R-HSA-2142753 1/59 0.7859216745432589 0.9999953328203589 0 0 0.651650342144103 0.15698135680391712 CYP1A1 RHOQ GTPase Cycle R-HSA-9013406 1/59 0.7859216745432589 0.9999953328203589 0 0 0.651650342144103 0.15698135680391712 PLEKHG3 Iron Uptake And Transport R-HSA-917937 1/59 0.7859216745432589 0.9999953328203589 0 0 0.651650342144103 0.15698135680391712 TF Signaling By ROBO Receptors R-HSA-376176 4/209 0.7897233921151894 0.9999953328203589 0 0 0.7361939764211732 0.1737951756124101 ROBO2;AKAP5;SLIT2;NTN1 Recruitment And ATM-mediated Phosphorylation Of Repair And Signal Proteins At DNA Double Strand Breaks R-HSA-5693565 1/60 0.7914504612697292 0.9999953328203589 0 0 0.6405724460858669 0.14982220188653983 CNKSR3 FCGR3A-mediated Phagocytosis R-HSA-9664422 1/60 0.7914504612697292 0.9999953328203589 0 0 0.6405724460858669 0.14982220188653983 ARPC1A Formation Of beta-catenin:TCF Transactivating Complex R-HSA-201722 1/60 0.7914504612697292 0.9999953328203589 0 0 0.6405724460858669 0.14982220188653983 TLE2 Transcriptional Regulation By MECP2 R-HSA-8986944 1/60 0.7914504612697292 0.9999953328203589 0 0 0.6405724460858669 0.14982220188653983 MEF2C Meiotic Synapsis R-HSA-1221632 1/60 0.7914504612697292 0.9999953328203589 0 0 0.6405724460858669 0.14982220188653983 SYCP2 Reproduction R-HSA-1474165 2/113 0.7917428662111212 0.9999953328203589 0 0 0.6804699436278384 0.15890239113477056 SYCP2;TEX15 Cell-cell Junction Organization R-HSA-421270 1/61 0.7968367304449221 0.9999953328203589 0 0 0.629863813229572 0.14304552132544043 CLDN19 DNA Double Strand Break Response R-HSA-5693606 1/61 0.7968367304449221 0.9999953328203589 0 0 0.629863813229572 0.14304552132544043 CNKSR3 Protein Localization R-HSA-9609507 3/164 0.7977470984899284 0.9999953328203589 0 0 0.7032705745341615 0.1589135866256003 SYCP2;ZNF260;PIPOX RAB Geranylgeranylation R-HSA-8873719 1/62 0.8020841486305534 0.9999953328203589 0 0 0.6195062830898769 0.1366270017540184 RAB6B RHO GTPases Activate PKNs R-HSA-5625740 1/62 0.8020841486305534 0.9999953328203589 0 0 0.6195062830898769 0.1366270017540184 AREG Regulation Of Actin Dynamics For Phagocytic Cup Formation R-HSA-2029482 1/62 0.8020841486305534 0.9999953328203589 0 0 0.6195062830898769 0.1366270017540184 ARPC1A Signaling By BRAF And RAF1 Fusions R-HSA-6802952 1/62 0.8020841486305534 0.9999953328203589 0 0 0.6195062830898769 0.1366270017540184 FN1 MAP Kinase Activation R-HSA-450294 1/62 0.8020841486305534 0.9999953328203589 0 0 0.6195062830898769 0.1366270017540184 MEF2C PPARA Activates Gene Expression R-HSA-1989781 2/116 0.8036504057980607 0.9999953328203589 0 0 0.6624602441776957 0.14480779624107276 ABCB4;CYP1A1 Synthesis Of Substrates In N-glycan Biosythesis R-HSA-446219 1/63 0.8071962884828104 0.9999953328203589 0 0 0.6094828668256558 0.13054416492895649 NPL Hemostasis R-HSA-109582 12/576 0.8111761358156618 0.9999953328203589 0 0 0.8003468550399729 0.16748863833765984 TF;ITGAM;ITGA4;ACTN2;KCNMB1;PDE1A;SELENOP;FN1;KIF12;A1BG;MERTK;THBS1 Regulation Of Lipid Metabolism By PPARalpha R-HSA-400206 2/118 0.81124934948772 0.9999953328203589 0 0 0.6509712979767426 0.13617005426736686 ABCB4;CYP1A1 Cytochrome P450 - Arranged By Substrate Type R-HSA-211897 1/65 0.817028567220869 0.9999953328203589 0 0 0.5903757295719845 0.11930384694336203 CYP1A1 Cell-Cell Communication R-HSA-1500931 2/120 0.8185850278891929 0.9999953328203589 0 0 0.6398718075792117 0.12808826189021164 ACTN2;CLDN19 Glycosaminoglycan Metabolism R-HSA-1630316 2/120 0.8185850278891929 0.9999953328203589 0 0 0.6398718075792117 0.12808826189021164 CHSY3;HS3ST5 RUNX1 Regulates Genes Involved In Megakaryocyte Differentiation And Platelet Function R-HSA-8936459 1/66 0.8217554018934563 0.9999953328203589 0 0 0.581263094881772 0.11410920713678298 THBS1 SARS-CoV-2 Activates/Modulates Innate And Adaptive Immune Responses R-HSA-9705671 2/121 0.8221563519118966 0.9999953328203589 0 0 0.6344619719232722 0.12424332079265372 MASP1;MBL2 RHO GTPase Effectors R-HSA-195258 5/269 0.8256488243297062 0.9999953328203589 0 0 0.7137923351158645 0.13675243844495635 ARPC1A;NOX3;CYBB;IQGAP2;AREG Rab Regulation Of Trafficking R-HSA-9007101 2/122 0.8256645066472815 0.9999953328203589 0 0 0.6291423001949318 0.12052274841325254 DENND2C;RAB6B Fatty Acid Metabolism R-HSA-8978868 3/173 0.8261610254558538 0.9999953328203589 0 0 0.6657284007352942 0.12713120909587558 ACOXL;SYCP2;CYP1A1 RNA Polymerase II Transcription Termination R-HSA-73856 1/67 0.826360354470764 0.9999953328203589 0 0 0.5724266006367174 0.1091756833749329 POLDIP3 HDR Thru Homologous Recombination (HRR) R-HSA-5685942 1/67 0.826360354470764 0.9999953328203589 0 0 0.5724266006367174 0.1091756833749329 RAD9B Costimulation By CD28 Family R-HSA-388841 1/68 0.8308465616318321 0.9999953328203589 0 0 0.5638538823392764 0.10448784425396412 BTLA MAPK Family Signaling Cascades R-HSA-5683057 6/318 0.8311183504033179 0.9999953328203589 0 0 0.7243841620069518 0.13399880977618586 ACTN2;RASGRF2;FN1;AREG;FOXO1;RAG1 Circadian Clock R-HSA-400253 1/69 0.8352170796446533 0.9999953328203589 0 0 0.5555333028152896 0.10003133325606448 MEF2C Interleukin-17 Signaling R-HSA-448424 1/69 0.8352170796446533 0.9999953328203589 0 0 0.5555333028152896 0.10003133325606448 MEF2C Intra-Golgi And Retrograde Golgi-to-ER Traffic R-HSA-6811442 3/181 0.8484856282462051 0.9999953328203589 0 0 0.6355446804775281 0.10442134616627213 NAPSA;KIF12;RAB6B Extra-nuclear Estrogen Signaling R-HSA-9009391 1/73 0.8516006780807908 0.9999953328203589 0 0 0.5245622568093385 0.08426439560935833 AREG Cell Death Signaling Via NRAGE, NRIF And NADE R-HSA-204998 1/74 0.8554359149256501 0.9999953328203589 0 0 0.5173498214380896 0.08078112119426266 RASGRF2 Formation Of Cornified Envelope R-HSA-6809371 1/74 0.8554359149256501 0.9999953328203589 0 0 0.5173498214380896 0.08078112119426266 LCE2A Transport Of Mature mRNA Derived From An Intron-Containing Transcript R-HSA-159236 1/74 0.8554359149256501 0.9999953328203589 0 0 0.5173498214380896 0.08078112119426266 POLDIP3 ISG15 Antiviral Mechanism R-HSA-1169408 1/75 0.8591722198315547 0.9999953328203589 0 0 0.5103323167525502 0.07746124405124934 EIF4A1 ER To Golgi Anterograde Transport R-HSA-199977 2/133 0.8603331779644107 0.9999953328203589 0 0 0.5759861910926596 0.08664879859880743 NAPSA;AREG Neddylation R-HSA-8951664 4/237 0.8626882951288511 0.9999953328203589 0 0 0.6467836355542864 0.09553113351286759 ZBTB16;ASB9;FBXO10;FBXL22 ABC Transporter Disorders R-HSA-5619084 1/77 0.8663581570553881 0.9999953328203589 0 0 0.4968513209092771 0.07127674014383355 ABCB4 Biosynthesis Of N-glycan Precursor (Dolichol LLO) And Transfer To Protein R-HSA-446193 1/77 0.8663581570553881 0.9999953328203589 0 0 0.4968513209092771 0.07127674014383355 NPL Regulation Of Insulin Secretion R-HSA-422356 1/77 0.8663581570553881 0.9999953328203589 0 0 0.4968513209092771 0.07127674014383355 AKAP5 G2/M DNA Damage Checkpoint R-HSA-69473 1/77 0.8663581570553881 0.9999953328203589 0 0 0.4968513209092771 0.07127674014383355 RAD9B Oncogenic MAPK Signaling R-HSA-6802957 1/78 0.8698126889017213 0.9999953328203589 0 0 0.4903734397897822 0.06839600781460052 FN1 Constitutive Signaling By Aberrant PI3K In Cancer R-HSA-2219530 1/78 0.8698126889017213 0.9999953328203589 0 0 0.4903734397897822 0.06839600781460052 AREG G Alpha (12/13) Signaling Events R-HSA-416482 1/78 0.8698126889017213 0.9999953328203589 0 0 0.4903734397897822 0.06839600781460052 RASGRF2 Transport Of Small Molecules R-HSA-382551 14/706 0.8740159422909943 0.9999953328203589 0 0 0.7588926193855065 0.10218994761482328 SLC47A2;SLC24A3;TRPA1;ABCB4;ATP11A;SLC2A4;SLC4A4;SLC7A2;PARL;ANO1;TF;CLCA2;LCN1;EMB Processing Of DNA Double-Strand Break Ends R-HSA-5693607 1/80 0.8764566599113439 0.9999953328203589 0 0 0.4779096685218933 0.06302100297293572 RAD9B COPI-mediated Anterograde Transport R-HSA-6807878 1/80 0.8764566599113439 0.9999953328203589 0 0 0.4779096685218933 0.06302100297293572 NAPSA Signaling By WNT R-HSA-195721 5/294 0.878097209453258 0.9999953328203589 0 0 0.6511975032227424 0.08465435645653197 TLE2;SFRP2;GNAT2;WNT9B;PDE6A Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2/140 0.8789884055161008 0.9999953328203589 0 0 0.546571743368082 0.07049877577184595 MEF2C;ITGAM PI Metabolism R-HSA-1483255 1/82 0.8827621817065744 0.9999953328203589 0 0 0.46606139213143105 0.05811759672247938 PIK3C2G Beta-catenin Independent WNT Signaling R-HSA-3858494 2/142 0.8838803948739319 0.9999953328203589 0 0 0.538707880813144 0.06649461289745896 GNAT2;PDE6A Antiviral Mechanism By IFN-stimulated Genes R-HSA-1169410 1/83 0.8857934367927076 0.9999953328203589 0 0 0.46035399069944005 0.055827817545055045 EIF4A1 Transport Of Mature Transcript To Cytoplasm R-HSA-72202 1/83 0.8857934367927076 0.9999953328203589 0 0 0.46035399069944005 0.055827817545055045 POLDIP3 Diseases Of Glycosylation R-HSA-3781865 2/143 0.8862572387453975 0.9999953328203589 0 0 0.5348596076479615 0.06458324573238688 THBS1;ADAMTS20 Degradation Of Beta-Catenin By Destruction Complex R-HSA-195253 1/84 0.8887464635967497 0.9999953328203589 0 0 0.45478411701279825 0.053638729064387596 TLE2 Transcriptional Regulation Of White Adipocyte Differentiation R-HSA-381340 1/84 0.8887464635967497 0.9999953328203589 0 0 0.45478411701279825 0.053638729064387596 SLC2A4 Cell Junction Organization R-HSA-446728 1/86 0.8944258410133792 0.9999953328203589 0 0 0.44403753719386585 0.049542726683178766 CLDN19 RHOA GTPase Cycle R-HSA-8980692 2/147 0.8953209878186303 0.9999953328203589 0 0 0.5199973112858776 0.05749765198774363 PLEKHG3;RASGRF2 RAC2 GTPase Cycle R-HSA-9013404 1/87 0.8971560674317524 0.9999953328203589 0 0 0.4388516876300787 0.047626574179682545 CYBB Fcgamma Receptor (FCGR) Dependent Phagocytosis R-HSA-2029480 1/87 0.8971560674317524 0.9999953328203589 0 0 0.4388516876300787 0.047626574179682545 ARPC1A Vesicle-mediated Transport R-HSA-5653656 12/637 0.8985429495291141 0.9999953328203589 0 0 0.7199045725646124 0.07701594732300863 DENND2C;MARCO;NAPSA;TF;SYT2;ARPC1A;KIF12;MASP1;SLC2A4;AREG;RAB6B;SH3GL2 Antigen Processing: Ubiquitination And Proteasome Degradation R-HSA-983168 5/307 0.8996256935056235 0.9999953328203589 0 0 0.6227437995065576 0.06587165843206826 ZBTB16;GLMN;ASB9;FBXO10;FBXL22 Opioid Signaling R-HSA-111885 1/88 0.8998158202736053 0.9999953328203589 0 0 0.43378505299879244 0.045792597522446486 PDE1A Signaling By Interleukins R-HSA-449147 8/453 0.9004455367969901 0.9999953328203589 0 0 0.6751324158411454 0.07079816401987181 MEF2C;ITGAM;FN1;IL19;IL12A;LGALS9;FOXO1;RAG1 Peptide Hormone Metabolism R-HSA-2980736 1/89 0.902406915109691 0.9999953328203589 0 0 0.4288335691545808 0.044036805681601114 PCSK2 Sphingolipid Metabolism R-HSA-428157 1/89 0.902406915109691 0.9999953328203589 0 0 0.4288335691545808 0.044036805681601114 GALC Mitochondrial Biogenesis R-HSA-1592230 1/89 0.902406915109691 0.9999953328203589 0 0 0.4288335691545808 0.044036805681601114 MEF2C Regulation Of TP53 Activity Thru Phosphorylation R-HSA-6804756 1/90 0.9049311208764714 0.9999953328203589 0 0 0.4239933546102391 0.0423554299771276 RAD9B HCMV Late Events R-HSA-9610379 1/91 0.9073901609467881 0.9999953328203589 0 0 0.41926070038910507 0.04074490990096875 PCSK2 Class B/2 (Secretin Family Receptors) R-HSA-373080 1/92 0.9097857146042321 0.9999953328203589 0 0 0.41463206054645746 0.03920187977599132 WNT9B VEGFA-VEGFR2 Pathway R-HSA-4420097 1/93 0.9121194177416982 0.9999953328203589 0 0 0.41010404330908473 0.03772315671602569 CYBB Transcriptional Regulation By RUNX3 R-HSA-8878159 1/95 0.9166076070835683 0.9999953328203589 0 0 0.40133703121119296 0.03494674615317689 ITGA4 UCH Proteinases R-HSA-5689603 1/95 0.9166076070835683 0.9999953328203589 0 0 0.40133703121119296 0.03494674615317689 CNKSR3 P75 NTR Receptor-Mediated Signaling R-HSA-193704 1/95 0.9166076070835683 0.9999953328203589 0 0 0.40133703121119296 0.03494674615317689 RASGRF2 Metabolism Of Nucleotides R-HSA-15869 1/95 0.9166076070835683 0.9999953328203589 0 0 0.40133703121119296 0.03494674615317689 ENTPD8 HCMV Early Events R-HSA-9609690 1/96 0.9187651590709446 0.9999953328203589 0 0 0.3970919516690559 0.03364350796232958 PCSK2 MyD88 Cascade Initiated On Plasma Membrane R-HSA-975871 1/96 0.9187651590709446 0.9999953328203589 0 0 0.3970919516690559 0.03364350796232958 MEF2C Potential Therapeutics For SARS R-HSA-9679191 1/97 0.920866994229178 0.9999953328203589 0 0 0.3929353112840467 0.032393456479374395 ITGA4 RAF/MAP Kinase Cascade R-HSA-5673001 4/271 0.9212050923075309 0.9999953328203589 0 0 0.5634248774159503 0.04624173509729733 ACTN2;RASGRF2;FN1;AREG Hedgehog Off State R-HSA-5610787 1/98 0.9229145487539389 0.9999953328203589 0 0 0.3888643748245016 0.031194166884430125 ADCY10 Toll-like Receptor Cascades R-HSA-168898 2/162 0.9236525983967018 0.9999953328203589 0 0 0.4708820662768031 0.03739710233066078 MEF2C;ITGAM SLC Transporter Disorders R-HSA-5619102 1/99 0.9249092216760486 0.9999953328203589 0 0 0.38487651870086553 0.030043339819162223 SLC4A4 Class I MHC Mediated Antigen Processing And Presentation R-HSA-983169 6/378 0.9266726939799028 0.9999953328203589 0 0 0.6056467456746308 0.046122941122741484 ZBTB16;GLMN;ASB9;CYBB;FBXO10;FBXL22 Transport To Golgi And Subsequent Modification R-HSA-948021 2/164 0.9268328966740045 0.9999953328203589 0 0 0.46502057613168724 0.0353331897666709 NAPSA;AREG TNFR2 Non-Canonical NF-kB Pathway R-HSA-5668541 1/100 0.9268523762977592 0.9999953328203589 0 0 0.38096922532720195 0.02893879378845248 TNFRSF11A TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation R-HSA-975138 1/101 0.928745340598762 0.9999953328203589 0 0 0.37714007782101167 0.027878458480696276 MEF2C MAPK1/MAPK3 Signaling R-HSA-5684996 4/277 0.9288306486625483 0.9999953328203589 0 0 0.5508698737661556 0.040670089838119726 ACTN2;RASGRF2;FN1;AREG ABC-family Proteins Mediated Transport R-HSA-382556 1/102 0.930589408550008 0.9999953328203589 0 0 0.37338675501791424 0.02686036815665726 ABCB4 Signaling By VEGF R-HSA-194138 1/102 0.930589408550008 0.9999953328203589 0 0 0.37338675501791424 0.02686036815665726 CYBB MyD88 Dependent Cascade Initiated On Endosome R-HSA-975155 1/102 0.930589408550008 0.9999953328203589 0 0 0.37338675501791424 0.02686036815665726 MEF2C Regulation Of Expression Of SLITs And ROBOs R-HSA-9010553 2/167 0.9313699500406207 0.9999953328203589 0 0 0.45649477228424595 0.03245619042189594 ROBO2;SLIT2 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1/103 0.9323858407202352 0.9999953328203589 0 0 0.36970702677958345 0.025882655745443503 MEF2C Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1/103 0.9323858407202352 0.9999953328203589 0 0 0.36970702677958345 0.025882655745443503 MEF2C SUMO E3 Ligases SUMOylate Target Proteins R-HSA-3108232 2/168 0.9328222952258374 0.9999953328203589 0 0 0.4537213180206205 0.03155203556977973 THRB;AREG Antigen processing-Cross Presentation R-HSA-1236975 1/104 0.9341358653505485 0.9999953328203589 0 0 0.3660987495750066 0.024943547132763377 CYBB MHC Class II Antigen Presentation R-HSA-2132295 1/104 0.9341358653505485 0.9999953328203589 0 0 0.3660987495750066 0.024943547132763377 SH3GL2 Integration Of Energy Metabolism R-HSA-163685 1/105 0.9358406790287355 0.9999953328203589 0 0 0.36255986231667164 0.024041355965397478 AKAP5 tRNA Processing R-HSA-72306 1/105 0.9358406790287355 0.9999953328203589 0 0 0.36255986231667164 0.024041355965397478 PRORP PI5P, PP2A And IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1/106 0.9375014475321249 0.9999953328203589 0 0 0.35908838243468594 0.02317447871567804 AREG Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1/106 0.9375014475321249 0.9999953328203589 0 0 0.35908838243468594 0.02317447871567804 MEF2C MyD88-independent TLR4 Cascade R-HSA-166166 1/107 0.9391193066355789 0.9999953328203589 0 0 0.35568240217311503 0.022341390064988306 MEF2C L13a-mediated Translational Silencing Of Ceruloplasmin Expression R-HSA-156827 1/108 0.9406953627694209 0.9999953328203589 0 0 0.35234008509400344 0.02154063862680388 EIF4A1 SUMOylation R-HSA-2990846 2/174 0.9409436643677161 0.9999953328203589 0 0 0.4377578312706832 0.026647198655185434 THRB;AREG Degradation Of Extracellular Matrix R-HSA-1474228 1/109 0.9422306941858026 0.9999953328203589 0 0 0.34905966277561606 0.020770842741198576 TLL1 GTP Hydrolysis And Joining Of 60S Ribosomal Subunit R-HSA-72706 1/109 0.9422306941858026 0.9999953328203589 0 0 0.34905966277561606 0.020770842741198576 EIF4A1 Disorders Of Transmembrane Transporters R-HSA-5619115 2/176 0.9434372319080792 0.9999953328203589 0 0 0.43268132015863414 0.025193061650511016 ABCB4;SLC4A4 Signaling By Receptor Tyrosine Kinases R-HSA-9006934 8/496 0.9437214096607293 0.9999953328203589 0 0 0.6142529181621237 0.03558015389282644 MEF2C;TF;SPINT1;CYBB;GABRG3;AREG;THBS1;SH3GL2 MyD88:MAL(TIRAP) Cascade Initiated On Plasma Membrane R-HSA-166058 1/112 0.946602708315172 0.9999953328203589 0 0 0.3395730360710906 0.018634342154190183 MEF2C Membrane Trafficking R-HSA-199991 10/599 0.9475989214147604 0.9999953328203589 0 0 0.6352771100539596 0.034193120184650164 DENND2C;NAPSA;TF;SYT2;ARPC1A;KIF12;SLC2A4;AREG;RAB6B;SH3GL2 Negative Regulation Of PI3K/AKT Network R-HSA-199418 1/113 0.9479853767709878 0.9999953328203589 0 0 0.3365237632017788 0.017975821377984737 AREG Selenoamino Acid Metabolism R-HSA-2408522 1/114 0.9493323084323022 0.9999953328203589 0 0 0.33352845976378226 0.017342270773584818 INMT HDR Thru Homologous Recombination (HRR) Or Single Strand Annealing (SSA) R-HSA-5693567 1/114 0.9493323084323022 0.9999953328203589 0 0 0.33352845976378226 0.017342270773584818 RAD9B Cap-dependent Translation Initiation R-HSA-72737 1/116 0.9519226255880635 0.9999953328203589 0 0 0.32769412958890204 0.016145988887769615 EIF4A1 Diseases Of Metabolism R-HSA-5668914 3/247 0.9551807294261726 0.9999953328203589 0 0 0.46205014088114754 0.021187175646952796 OPLAH;THBS1;ADAMTS20 Transcriptional Regulation By RUNX2 R-HSA-8878166 1/119 0.9555623648224306 0.9999953328203589 0 0 0.3193134603970191 0.014514472572057843 AREG Homology Directed Repair R-HSA-5693538 1/119 0.9555623648224306 0.9999953328203589 0 0 0.3193134603970191 0.014514472572057843 RAD9B HCMV Infection R-HSA-9609646 1/121 0.9578347268522335 0.9999953328203589 0 0 0.3139591439688716 0.013525370859815448 PCSK2 Immunoregulatory Interactions Between A Lymphoid And A non-Lymphoid Cell R-HSA-198933 1/123 0.9599910969483151 0.9999953328203589 0 0 0.30878037889902404 0.012607894581649348 ITGA4 SARS-CoV-2-host Interactions R-HSA-9705683 2/196 0.9634347988801202 0.9999953328203589 0 0 0.3876730773095396 0.014441002216759998 MASP1;MBL2 DNA Replication Pre-Initiation R-HSA-69002 1/127 0.9639791998659188 0.9999953328203589 0 0 0.2989160644802668 0.010965903668906249 RPA4 Glycerophospholipid Biosynthesis R-HSA-1483206 1/127 0.9639791998659188 0.9999953328203589 0 0 0.2989160644802668 0.010965903668906249 PLB1 TCF Dependent Signaling In Response To WNT R-HSA-201681 2/198 0.9650115278805552 0.9999953328203589 0 0 0.383677447587222 0.013664761203203516 TLE2;SFRP2 G1/S Transition R-HSA-69206 1/129 0.965821865921937 0.9999953328203589 0 0 0.29421510214007784 0.0102315848441031 RPA4 ADORA2B Mediated Anti-Inflammatory Cytokine Production R-HSA-9660821 1/131 0.9675704362385524 0.9999953328203589 0 0 0.2896587847949716 0.009549196919947914 GPR83 Signaling By NOTCH R-HSA-157118 2/203 0.9686727566555022 0.9999953328203589 0 0 0.3740362514910826 0.01190498910130432 TLE2;DTX4 Signaling By Hedgehog R-HSA-5358351 1/135 0.9708042298499983 0.9999953328203589 0 0 0.2809541785237238 0.008324798194702682 ADCY10 Factors Involved In Megakaryocyte Development And Platelet Production R-HSA-983231 1/136 0.9715610698962263 0.9999953328203589 0 0 0.2788586251621271 0.008045392216556526 KIF12 Phospholipid Metabolism R-HSA-1483257 2/208 0.9719638629549706 0.9999953328203589 0 0 0.3648630746229111 0.010375484734111144 PIK3C2G;PLB1 RHO GTPase Cycle R-HSA-9012999 6/441 0.9724639052179281 0.9999953328203589 0 0 0.5162251879953933 0.014414204703090348 PLEKHG3;RASGRF2;NOX3;CYBB;IQGAP2;RHOBTB1 Death Receptor Signaling R-HSA-73887 1/139 0.9737160952033417 0.9999953328203589 0 0 0.27275418710878024 0.0072649444762026266 RASGRF2 G Alpha (Q) Signaling Events R-HSA-416476 2/212 0.9743542610883147 0.9999953328203589 0 0 0.35783904204956835 0.009296774151765585 XCR1;EDN2 Asparagine N-linked Glycosylation R-HSA-446203 3/282 0.9775946623616263 0.9999953328203589 0 0 0.40335181451612906 0.009140012829759176 NAPSA;NPL;AREG Mitotic G1 Phase And G1/S Transition R-HSA-453279 1/147 0.9786988355699474 0.9999953328203589 0 0 0.2577021480731304 0.005548664405731929 RPA4 Metabolism Of Carbohydrates R-HSA-71387 3/285 0.9789131038505452 0.9999953328203589 0 0 0.3989985039893617 0.008503615917055745 ALDH1A1;CHSY3;HS3ST5 G2/M Checkpoints R-HSA-69481 1/148 0.9792513394555699 0.9999953328203589 0 0 0.25593583736996744 0.005366190987399047 RAD9B Metabolism Of Steroids R-HSA-8957322 1/153 0.9818065302590476 0.9999953328203589 0 0 0.24745289780872415 0.0045434841580522 SYCP2 Neutrophil Degranulation R-HSA-6798695 6/468 0.9823830651654236 0.9999953328203589 0 0 0.48536728497435766 0.00862689869156041 CRACR2A;ITGAM;CYBB;A1BG;ATP11A;IQGAP2 Developmental Biology R-HSA-1266738 18/1073 0.9826228730278327 0.9999953328203589 0 0 0.6326871179684743 0.01109093017440676 ROBO2;MEF2C;EPHA7;SEMA4D;ONECUT3;ARPC1A;AKAP5;SLC2A4;NTN1;FOXO1;LCE2A;CACNB4;ABLIM2;CHL1;SLIT2;EPHB1;PLXNA4;SH3GL2 DNA Replication R-HSA-69306 1/155 0.982738364364882 0.9999953328203589 0 0 0.2442139572489767 0.004252340027550553 RPA4 Regulation Of TP53 Activity R-HSA-5633007 1/157 0.9836225525670976 0.9999953328203589 0 0 0.2410580664471715 0.003980601567541318 RAD9B Intracellular Signaling By Second Messengers R-HSA-9006925 3/306 0.9862737552336978 0.9999953328203589 0 0 0.370939047029703 0.005126867525487255 PDE1A;AREG;FOXO1 Anti-inflammatory Response Favoring Leishmania Infection R-HSA-9662851 1/165 0.9867296589988667 0.9999953328203589 0 0 0.22920423270380563 0.0030619803241430663 GPR83 Processing Of Capped Intron-Containing Pre-mRNA R-HSA-72203 2/242 0.986964127773839 0.9999953328203589 0 0 0.31262183235867447 0.004102093920045226 POLDIP3;ELAVL2 DNA Repair R-HSA-73894 3/310 0.987363072332164 0.9999953328203589 0 0 0.3660296213355049 0.004654964414665168 PRKDC;CNKSR3;RAD9B Cytokine Signaling In Immune System R-HSA-1280215 10/702 0.9873674063074539 0.9999953328203589 0 0 0.537772563383506 0.006836736647838826 EIF4A1;MEF2C;ITGAM;FN1;IL19;IL12A;TNFRSF11A;LGALS9;FOXO1;RAG1 Leishmania Infection R-HSA-9658195 2/247 0.9883695353282594 0.9999953328203589 0 0 0.30616223097426104 0.0035816779106772833 ARPC1A;GPR83 Sensory Perception R-HSA-9709957 8/616 0.99069265342044 0.9999953328203589 0 0 0.4899044949652237 0.004581062920686634 KCNMB1;PCDH15;LHFPL5;XIRP2;OR2M3;PDE6A;OR2T6;PLB1 mRNA Splicing - Major Pathway R-HSA-72163 1/181 0.991289264137318 0.9999953328203589 0 0 0.20865758754863814 0.001825523551090986 ELAVL2 Signaling By Nuclear Receptors R-HSA-9006931 2/260 0.9913680368749819 0.9999953328203589 0 0 0.2905390090212612 0.0025188088525598994 ALDH1A1;AREG Cellular Response To Chemical Stress R-HSA-9711123 1/182 0.9915155458987072 0.9999953328203589 0 0 0.20749403443902228 0.0017679844540400066 CYBB Metabolism Of Vitamins And Cofactors R-HSA-196854 1/186 0.9923634826902133 0.9999953328203589 0 0 0.20296561152592282 0.0015558988200570364 PLB1 ESR-mediated Signaling R-HSA-8939211 1/188 0.9927551696538801 0.9999953328203589 0 0 0.20077404856530515 0.0014598685784984486 AREG PIP3 Activates AKT Signaling R-HSA-1257604 2/268 0.9928226083429297 0.9999953328203589 0 0 0.28168374151753656 0.0020290449031949258 AREG;FOXO1 mRNA Splicing R-HSA-72172 1/189 0.9929434249836039 0.9999953328203589 0 0 0.1996957529596821 0.001414163525734838 ELAVL2 Signaling By Rho GTPases R-HSA-194315 8/644 0.9941053946957058 0.9999953328203589 0 0 0.46764169550816864 0.0027647197136101047 PLEKHG3;RASGRF2;ARPC1A;NOX3;CYBB;IQGAP2;AREG;RHOBTB1 Deubiquitination R-HSA-5688426 2/279 0.9944379107261 0.9999953328203589 0 0 0.2703429251025679 0.0015078688327585918 CNKSR3;AREG rRNA Processing R-HSA-72312 1/199 0.9945771633127781 0.9999953328203589 0 0 0.18951185001768658 0.0010304884303542429 PRORP Interferon Signaling R-HSA-913531 1/200 0.9947181339012048 0.9999953328203589 0 0 0.1885497526543222 9.98533935337291E-4 EIF4A1 Ub-specific Processing Proteases R-HSA-5689880 1/201 0.9948554448904028 0.9999953328203589 0 0 0.18759727626459144 9.675955901476894E-4 AREG SARS-CoV-2 Infection R-HSA-9694516 2/283 0.9949321055181007 0.9999953328203589 0 0 0.26643913064591096 0.001353718556086761 MASP1;MBL2 Transcriptional Regulation By RUNX1 R-HSA-8878171 1/204 0.9952463556729599 0.9999953328203589 0 0 0.18479615111843745 8.805497476908605E-4 THBS1 Signaling By Rho GTPases, Miro GTPases And RHOBTB3 R-HSA-9716542 8/660 0.9954839608157097 0.9999953328203589 0 0 0.45577860868092107 0.0020629758100334204 PLEKHG3;RASGRF2;ARPC1A;NOX3;CYBB;IQGAP2;AREG;RHOBTB1 Keratinization R-HSA-6805567 1/208 0.995721814630569 0.9999953328203589 0 0 0.18118761630857722 7.76817080320507E-4 LCE2A Metabolism Of Amino Acids And Derivatives R-HSA-71291 3/364 0.9959626861162035 0.9999953328203589 0 0 0.31040079639889195 0.001255722025958509 DCT;PIPOX;INMT SARS-CoV Infections R-HSA-9679506 3/369 0.9963750789203561 0.9999953328203589 0 0 0.3060803022540984 0.0011115327683303188 ITGA4;MASP1;MBL2 Adaptive Immune System R-HSA-1280218 9/733 0.9966216869894826 0.9999953328203589 0 0 0.46090286725045315 0.0015597102336297726 ITGA4;ZBTB16;GLMN;ASB9;BTLA;CYBB;FBXO10;FBXL22;SH3GL2 Generic Transcription Pathway R-HSA-212436 17/1190 0.9979885293451819 0.9999953328203589 0 0 0.532914265758687 0.00107302094433079 ZNF583;MEF2C;THRB;ITGA4;NR1I3;ZNF10;ZNF99;AREG;THBS1;FOXO1;TP53AIP1;ZNF528;ZNF426;RAD9B;ZNF157;PLXNA4;ZNF585A Innate Immune System R-HSA-168249 14/1035 0.9979933263868542 0.9999953328203589 0 0 0.5053477765331238 0.0010150868636093831 MEF2C;ITGAM;PRKDC;ARPC1A;CYBB;A1BG;ATP11A;IQGAP2;DTX4;C4A;CRACR2A;C5;MASP1;MBL2 Metabolism Of Lipids R-HSA-556833 8/732 0.9986962607099907 0.9999953328203589 0 0 0.40888336765939826 5.334251106925267E-4 GALC;ACOXL;SYCP2;ABCB4;CYP1A1;FITM1;PIK3C2G;PLB1 Post-translational Protein Modification R-HSA-597592 20/1383 0.9988570371800081 0.9999953328203589 0 0 0.5371988409405871 6.143494583511236E-4 NAPSA;THRB;PRKDC;ZBTB16;FN1;IZUMO1R;NPL;FBXO10;AREG;THBS1;FBXL22;ADAMTS20;C4A;TF;CNKSR3;ASB9;RNF152;RAB6B;SCG2;TECTA Diseases Of Signal Transduction By Growth Factor Receptors And Second Messengers R-HSA-5663202 3/424 0.998912896035418 0.9999953328203589 0 0 0.2653280878859858 2.885961116816503E-4 FN1;AREG;FOXO1 Transcriptional Regulation By TP53 R-HSA-3700989 2/354 0.9990518464487954 0.9999953328203589 0 0 0.2119107744107744 2.0101926692874582E-4 TP53AIP1;RAD9B Cell Cycle Checkpoints R-HSA-69620 1/271 0.9991871241187967 0.9999953328203589 0 0 0.13845654993514916 1.1259375861465091E-4 RAD9B RNA Polymerase II Transcription R-HSA-73857 18/1312 0.9992665368073903 0.9999953328203589 0 0 0.5091414017334299 3.7357349596339056E-4 ZNF583;MEF2C;THRB;ITGA4;POLDIP3;NR1I3;ZNF10;ZNF99;AREG;THBS1;FOXO1;TP53AIP1;ZNF528;ZNF426;RAD9B;ZNF157;PLXNA4;ZNF585A Organelle Biogenesis And Maintenance R-HSA-1852241 1/275 0.9992684345191654 0.9999953328203589 0 0 0.13640688460336844 9.982708760350791E-5 MEF2C Translation R-HSA-72766 1/281 0.9993753748083696 0.9999953328203589 0 0 0.13344219010561423 8.337739608900819E-5 EIF4A1 Immune System R-HSA-168256 30/1943 0.9995121490271448 0.9999953328203589 0 0 0.568179736043673 2.772546719664318E-4 EIF4A1;ITGAM;PRKDC;ARPC1A;A1BG;TNFRSF11A;IQGAP2;DTX4;FOXO1;FBXL22;C4A;CRACR2A;C5;BTLA;IL12A;LGALS9;SH3GL2;MBL2;RAG1;MEF2C;ITGA4;ZBTB16;GLMN;FN1;IL19;CYBB;ATP11A;FBXO10;ASB9;MASP1 Expression And Translocation Of Olfactory Receptors R-HSA-9752946 2/393 0.9996275870014886 0.9999953328203589 0 0 0.19038502764441653 7.091506468243948E-5 OR2M3;OR2T6 Olfactory Signaling Pathway R-HSA-381753 2/401 0.999692698230647 0.9999953328203589 0 0 0.18648961585249674 5.731739623720455E-5 OR2M3;OR2T6 Signal Transduction R-HSA-162582 39/2465 0.9998360783340376 0.9999953328203589 0 0 0.5761299161049416 9.444791690011909E-5 RASGRF2;PDE1A;ARPC1A;NPY2R;RRH;GPR83;IQGAP2;DTX4;AREG;THBS1;FOXO1;RHOBTB1;C5;GNAT2;PCDHA4;PDE6A;SH3GL2;RAG1;PLEKHG3;MEF2C;TLE2;XCR1;EDN2;ACTN2;FN1;WNT9B;CYBB;HTR5A;GABRG3;ADCY10;CXCL11;TF;SFRP2;KEL;SPINT1;GPR183;ALDH1A1;NOX3;PDE3A Gene Expression (Transcription) R-HSA-74160 18/1449 0.999905086134162 0.9999953328203589 0 0 0.4569302608101439 4.33710757626698E-5 ZNF583;MEF2C;THRB;ITGA4;POLDIP3;NR1I3;ZNF10;ZNF99;AREG;THBS1;FOXO1;TP53AIP1;ZNF528;ZNF426;RAD9B;ZNF157;PLXNA4;ZNF585A Infectious Disease R-HSA-5663205 9/961 0.9999380448941695 0.9999953328203589 0 0 0.3462587604211645 2.145316271998143E-5 PCSK2;SYT2;SV2C;ITGA4;ARPC1A;GPR83;MASP1;SH3GL2;MBL2 Cell Cycle R-HSA-1640170 4/654 0.9999633010732919 0.9999953328203589 0 0 0.2268252295649556 8.324395224471865E-6 SYCP2;RPA4;TEX15;RAD9B Metabolism Of RNA R-HSA-8953854 4/666 0.999971038292014 0.9999953328203589 0 0 0.2225717005338741 6.4461499430279525E-6 EIF4A1;POLDIP3;PRORP;ELAVL2 Cellular Responses To Stimuli R-HSA-8953897 4/736 0.9999908316480776 0.9999953328203589 0 0 0.2005389624971929 1.838620210906609E-6 MEF2C;CYBB;SNCB;AREG Metabolism Of Proteins R-HSA-392499 22/1890 0.999992267427626 0.9999953328203589 0 0 0.42085340375535873 3.2542919854078027E-6 PCSK2;EIF4A1;NAPSA;THRB;PRKDC;ZBTB16;FN1;IZUMO1R;NPL;FBXO10;AREG;THBS1;FBXL22;ADAMTS20;C4A;TF;CNKSR3;ASB9;RNF152;RAB6B;SCG2;TECTA Disease R-HSA-1643685 18/1736 0.9999940260009161 0.9999953328203589 0 0 0.3745476350536279 2.237553912252834E-6 PCSK2;SYT2;ITGA4;ABCB4;ARPC1A;FN1;GPR83;OPLAH;SLC4A4;AREG;THBS1;FOXO1;ADAMTS20;SV2C;MASP1;RAD9B;SH3GL2;MBL2 Metabolism R-HSA-1430728 21/2049 0.999994410900744 0.9999953328203589 0 0 0.36592662242771246 2.045205928583248E-6 GSTM3;SYCP2;ABCB4;PIPOX;ENTPD8;MGST2;FITM1;PIK3C2G;HS3ST5;AKAP5;OPLAH;INMT;PLB1;ITPKB;GALC;ACOXL;AKR7A3;DCT;ALDH1A1;CYP1A1;CHSY3 Cellular Responses To Stress R-HSA-2262752 3/722 0.9999948985580076 0.9999953328203589 0 0 0.15293050243393602 7.801680770272548E-7 MEF2C;CYBB;AREG Cell Cycle, Mitotic R-HSA-69278 1/523 0.9999953328203589 0.9999953328203589 0 0 0.07067623775660807 3.2985946772402215E-7 RPA4