sce sce 2016-02-26T07:45:48Z 2016-03-24T12:37:57Z 12.00 7485 20175 240 315 False False S4_Table. KEGG pathway enriched analysis for the targets of different miRNAs between LP and NP group Pathway name Genes Count PValue Complement and coagulation cascades MASP1, C3, MASP2, C6, C5, FGG, FGB, KLKB1, SERPINE1, C2, PLAT, F10, C5AR1, F9, SERPING1, F7, C4BPA, PROC, C8A, C1QA, C8B, CD55, THBD, F3, CD59, F2, PLAU, F2R 28 2.29E-7 Hematopoietic cell lineage CSF3, CSF2, IL1R2, TNF, CD8A, CD8B, KITLG, ANPEP, ITGB3, KIT, IL7R, MS4A1, CD4, CD5, IL1A, EPO, IL6, CD3G, IL2RA, CD3D, CD3E, CD1D, CD38, CD55, CD19, CD36, CD34, CD59 28 2.9799999999999999E-5 Adipocytokine signaling pathway PRKAG3, TNF, RXRB, CHKB, LEPR, PRKAB2, RXRG, PRKAB1, NFKB1, ACACB, IRS1, ADIPOQ, CPT1A, PCK1, LEP, TNFRSF1A, ACSL1, CD36, SLC2A4, JAK2, ACSL4, ACSL3 22 2.32E-4 PPAR signaling pathway SLC27A1, PPARD, OLR1, RXRB, CHKB, SCD, RXRG, ACADL, ADIPOQ, MMP1, CPT1A, PCK1, ACSL1, CD36, SCD5, ACSL4, ACSL3, SLC27A2, FABP6, NR1H3, ANGPTL4 21 1.000868E-3 Glycolysis / Gluconeogenesis LDHC, LDHB, LDHA, ALDOC, HK2, ADH5, HK1, ACSS2, PDHB, PCK1, GPI, TPI1, GALM, DLD, ALDH2, ENO3, PGK1, GAPDH, PGK2 19 1.140879E-3 Cytokine-cytokine receptor interaction LEPR, TNFSF15, TGFB3, IL13, TNFSF13, TGFB1, IL10, CXCL10, CXCR6, FAS, XCR1, LTA, IL1A, LTBR, CD40, CCR9, IFNAR2, INHBA, TNFRSF9, CCR7, TNFSF13B, CCR5, CCR3, CCR2, IL12A, IL12B, CSF3, CCL1, CSF2, IL1R2, TNF, CCL2, TNFRSF12A, CCR1, CXCL2, CXCL9, KITLG, KIT, CCL5, IL7R, TNFRSF1A, CCL22, IL17A, IL12RB1, EPO, IL6, IL2RA, IL23R, TGFBR1, IL9, LEP, GH1, TNFSF10, CXCL14, BMPR1B 55 2.1407599999999998E-3 Thyroid cancer MAPK1, MAP2K1, NCOA4, MAP2K2, RXRB, TP53, RXRG, LEF1, CDH1, MYC, CTNNB1 11 4.77671E-3 Toll-like receptor signaling pathway TNF, TLR1, TLR2, CXCL9, TLR4, NFKB1, CCL5, TLR7, TLR9, CXCL10, TMED7, TICAM1, CASP8, TICAM2, PIK3R5, IL6, MAP2K1, MAP2K2, FADD, CD40, TAB1, IFNAR2, MAPK1, CD80, IL12A, IL12B 25 6.2356640000000001E-3 Primary immunodeficiency CD19, CD8A, CD3D, CD8B, CD3E, ICOS, LCK, CD4, CD40, IL7R, RFXANK, BTK 12 6.957062E-3 Prion diseases C8A, C1QA, C8B, MAPK1, IL6, MAP2K1, MAP2K2, C6, C5, LAMC1, CCL5, IL1A 12 6.957062E-3 Cell adhesion molecules (CAMs) CLDN16, CLDN7, CLDN18, OCLN, CLDN9, CLDN4, CD8A, CD8B, CLDN3, CLDN5, CDH1, CLDN10, ITGB1, CLDN15, VCAM1, ICOS, ITGAV, CD4, CD28, SELP, ICAM1, CLDN22, CD40, SDC1, CD80, CD34, PECAM1, VCAN, SELE 29 1.6329224999999999E-2 Pyruvate metabolism LDHC, LDHB, LDHA, DLD, ALDH2, ACACA, ACYP1, ACACB, ACSS2, MDH2, PDHB, PCK1 12 1.9858529E-2 Propanoate metabolism LDHC, LDHB, LDHA, MUT, ALDH2, ACACA, ACACB, ACSS2, PCCB, HADHA 10 2.9300221000000001E-2 Insulin signaling pathway PRKAG3, MAP2K1, MAP2K2, PHKG1, GRB2, PHKG2, PRKAB2, PRKAB1, ACACA, HK2, HK1, MKNK1, IGF2, ACACB, IRS1, PPP1CB, PCK1, MAPK1, INPP5K, SLC2A4, ARAF, GYS1, FASN, CALM3, PIK3R5, PTPN1, CRK, LIPE, CALM1 28 3.6635752000000001E-2 Intestinal immune network for IgA production IL6, LTBR, TGFB3, TNFSF13, CD40, PIGR, TGFB1, IL10, CCR9, TNFSF13B, CD80, ICOS, CD28 13 3.689655E-2 Leukocyte transendothelial migration CLDN16, CLDN7, CLDN18, OCLN, CLDN9, CLDN4, CLDN3, CLDN5, CLDN10, MMP2, ITGB1, CTNNB1, MYL9, VCL, CLDN15, VCAM1, PIK3R5, MSN, RHOH, ICAM1, CLDN22, ACTN1, ACTN2, VAV1, PECAM1 25 3.9425966E-2 Cysteine and methionine metabolism LDHC, ADI1, DNMT3A, LDHB, LDHA, GOT1, MAT1A, BHMT, AHCYL1, ENOPH1 10 4.2334284E-2 Colorectal cancer MAP2K1, MSH2, GRB2, TGFBR1, CYCS, TP53, TGFB3, SMAD4, SMAD3, LEF1, TGFB1, FZD6, CTNNB1, IGF1R, MAPK1, ARAF, PIK3R5, MYC, APC 19 4.3864610999999998E-2 Fatty acid metabolism ACSL1, ACADS, CHKB, ALDH2, ADH5, ACSL4, HADH, ACADL, ACSL3, HADHA, CPT1A 11 4.7757300000000003E-2 Hypertrophic cardiomyopathy (HCM) PRKAG3, IL6, ACTC1, CACNA2D1, TNF, MYL3, PRKAB2, PRKAB1, TGFB3, ITGB3, CACNB4, TPM2, CACNG1, ITGB1, TGFB1, DES, ATP2A2, DMD, ITGAV 19 4.8607222999999998E-2 p53 signaling pathway CDK1, CYCS, TP53, PMAIP1, SFN, CCNG1, ATM, CCNE2, CCNB1, CD82, GADD45G, CASP8, SERPINE1, FAS, PERP, THBS1 16 4.9934191000000003E-2 Steroid hormone biosynthesis UGT1A6, CYP17A1, AKR1C4, HSD3B1, CYP1A1, HSD11B1, HSD17B3, SRD5A2, SULT1E1, COMT, AKR1C1, CYP19A1 12 5.2114358999999999E-2 Chronic myeloid leukemia MAP2K1, MAP2K2, GRB2, TGFBR1, STAT5A, TP53, TGFB3, SMAD4, SMAD3, NFKB1, TGFB1, MAPK1, CDKN1B, ARAF, PIK3R5, CRK, MYC 17 5.7261841000000001E-2 Acute myeloid leukemia PPARD, MAP2K1, MAP2K2, GRB2, STAT5A, SPI1, LEF1, NFKB1, KIT, JUP, MAPK1, ARAF, PIK3R5, MYC 14 5.8349601000000001E-2 Citrate cycle (TCA cycle) DLST, ACO2, SDHD, DLD, IDH2, IDH3B, MDH2, PDHB, PCK1 9 6.1806673999999999E-2 Arginine and proline metabolism OTC, GLUD1, SAT2, ARG1, GOT1, CKM, P4HA1, ALDH2, ALDH4A1, NOS3, DAO, NOS2, OAT 13 6.3026998000000001E-2 Bladder cancer MAPK1, MAP2K1, MAP2K2, ARAF, TP53, CDH1, DAPK2, THBS1, MYC, MMP2, MMP1 11 6.4003679999999993E-2 Type I diabetes mellitus TNF, CD80, IL12A, GZMB, IGF2, FAS, IL12B, GAD1, IL1A, LTA, CD28 11 6.4003679999999993E-2 Amino sugar and nucleotide sugar metabolism GMPPB, GPI, CYB5R1, GNPDA1, GFPT1, GNPNAT1, HK2, HK1, FPGT, UXS1, PMM1 11 8.3429354999999997E-2