{"text_format":"3","workbook":"xls","n_sheets":2,"sheets":["40 clusters","Note"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"40 clusters","index":0,"n_rows":1392,"n_cols":17,"rows_kept":1392,"flags":["formulas_cached_only"]}
["cluster","gene in cluster","Probe Set ID"," Gene Symbol","Gene Title","Pathway ","Pathway Hyperlink","go biological process term"," go molecular function term","go cellular component term","Function","estimation errot","regulation","time delay","event score","correlation coefficient","p-value"]
[null,null,1]
[1,1,"200731_S_AT","PTP4A1","protein tyrosine phosphatase type IVA, member 1","---","---","protein amino acid dephosphorylation /// cell cycle /// multicellular organismal development /// dephosphorylation","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// hydrolase activity /// phosphoric monoester hydrolase activity","cytoplasm /// endosome /// endoplasmic reticulum /// membrane","cell cycle,proliferation",2.0412,-1,1.7714,6,0.7896,0.0347]
[1,2,"202255_S_AT","SIPA1L1","signal-induced proliferation-associated 1 like 1","---","---","regulation of small GTPase mediated signal transduction","GTPase activator activity /// protein binding","intracellular","signal transduction,signaling pathway",2.6957,1,0,4,0.7015,0.079]
[1,3,"203573_S_AT","RABGGTA","Rab geranylgeranyltransferase, alpha subunit","---","---","protein modification process /// visual perception /// protein amino acid prenylation","prenyltransferase activity /// Rab-protein geranylgeranyltransferase activity /// Rab-protein geranylgeranyltransferase activity /// protein binding /// zinc ion binding /// protein prenyltransferase activity /// transferase activity /// metal ion binding","---",null,2.9263,1,0,4,0.6648,0.1033]
[1,4,"209568_S_AT","RGL1","ral guanine nucleotide dissociation stimulator-like 1","---","---","signal transduction /// small GTPase mediated signal transduction /// small GTPase mediated signal transduction /// regulation of small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity /// protein binding /// Ral guanyl-nucleotide exchange factor activity","intracellular","signal transduction,signaling pathway",4.1663,1,0,4,0.5761,0.1758]
[1,5,"206907_AT","TNFSF9","tumor necrosis factor (ligand) superfamily, member 9","---","---","apoptosis /// immune response /// signal transduction /// cell-cell signaling /// cell proliferation","receptor binding /// cytokine activity /// tumor necrosis factor receptor binding","extracellular space /// integral to plasma membrane /// membrane /// integral to membrane","apoptosis:cell cycle,proliferation:immune response:signal transduction,signaling pathway",1.8037,-1,1.7326,6,0.7964,0.0321]
[1,6,"210439_AT","ICOS","inducible T-cell co-stimulator","---","---","immune response","protein binding","integral to plasma membrane /// external side of plasma membrane /// membrane /// integral to membrane /// integral to membrane","immune response",4.9664,-1,1.1578,2,0.6042,0.1507]
[1,7,"204958_AT","PLK3","polo-like kinase 3 (Drosophila)","---","---","regulation of progression through cell cycle /// protein amino acid phosphorylation /// protein amino acid phosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","membrane","cell cycle,proliferation",1.4262,-1,1.5174,4,0.7745,0.0409]
[1,8,"208476_S_AT","FRMD4A","FERM domain containing 4A","---","---","---","binding /// cytoskeletal protein binding","cytoplasm /// cytoskeleton /// extrinsic to membrane","unknown",3.947,-1,1.187,2,0.4611,0.2977]
[1,9,"209626_S_AT","OSBPL3","oxysterol binding protein-like 3","---","---","transport /// lipid transport /// steroid metabolic process","protein binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",3.2098,1,0.0005,4,0.3433,0.451]
[1,10,"202704_AT","TOB1","transducer of ERBB2, 1","Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","SMAD protein nuclear translocation /// negative regulation of cell proliferation /// negative regulation of BMP signaling pathway /// negative regulation of osteoblast differentiation","transcription corepressor activity /// SH3/SH2 adaptor activity /// protein binding /// protein binding /// SMAD binding","cytoplasm","cell growth,differentiation:cell cycle,proliferation:signal transduction,signaling pathway",4.6541,1,0,4,0.4192,0.3491]
[1,11,"206508_AT","CD70","CD70 molecule","---","---","induction of apoptosis /// immune response /// signal transduction /// cell-cell signaling /// cell proliferation","receptor binding /// cytokine activity /// tumor necrosis factor receptor binding /// protein binding","integral to membrane of membrane fraction /// extracellular space /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","apoptosis:cell cycle,proliferation:immune response:signal transduction,signaling pathway",3.2774,-1,0,6,0.681,0.0921]
[1,12,"219099_AT","C12orf5","chromosome 12 open reading frame 5","---","---","metabolic process","catalytic activity /// isomerase activity","intracellular","biosynthesis,metabolism,metabolic process,biosynthetic process",9.608,1,0.0005,4,0.8153,0.0254]
[1,13,"221640_S_AT","LRDD","leucine-rich repeats and death domain containing","---","---","apoptosis /// signal transduction /// signal transduction","death receptor binding /// protein binding /// protein binding","cytoplasm","apoptosis:signal transduction,signaling pathway",3.6573,1,0,4,0.4923,0.2617]
[1,14,"216252_X_AT","FAS","Fas (TNF receptor superfamily, member 6)","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","protein complex assembly /// apoptosis /// apoptosis /// anti-apoptosis /// induction of apoptosis /// immune response /// signal transduction /// signal transduction /// regulation of apoptosis","signal transducer activity /// receptor activity /// receptor activity /// receptor activity /// transmembrane receptor activity /// protein binding /// protein binding /// identical protein binding","soluble fraction /// cytosol /// membrane /// integral to membrane","apoptosis:immune response:signal transduction,signaling pathway",9.8119,-1,0,4,0.8462,0.0164]
[1,15,"209917_S_AT","TP53AP1","TP53 activated protein 1","---","---","response to stress /// response to DNA damage stimulus","signal transducer activity","nucleus",null,4.2446,1,0,0,0.116,0.8044]
[1,16,"215719_X_AT","FAS","Fas (TNF receptor superfamily, member 6)","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","protein complex assembly /// apoptosis /// apoptosis /// anti-apoptosis /// induction of apoptosis /// immune response /// signal transduction /// signal transduction /// regulation of apoptosis","signal transducer activity /// receptor activity /// receptor activity /// receptor activity /// transmembrane receptor activity /// protein binding /// protein binding /// identical protein binding","soluble fraction /// cytosol /// membrane /// integral to membrane","apoptosis:immune response:signal transduction,signaling pathway",8.3286,1,0.9625,4,0.8662,0.0117]
[1,17,"218627_AT","DRAM","damage-regulated autophagy modulator","---","---","autophagy /// apoptosis","---","lysosome /// membrane /// integral to membrane","apoptosis",7.1767,1,0,6,0.8119,0.0266]
[1,18,"205531_S_AT","GLS2","glutaminase 2 (liver, mitochondrial)","---","---","amino acid metabolic process /// glutamine metabolic process","glutaminase activity /// glutaminase activity /// protein binding /// hydrolase activity","mitochondrion /// mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",9.0114,1,0,4,0.4996,0.2536]
[]
[null,null,2]
[2,1,"210126_AT","PSG9","pregnancy specific beta-1-glycoprotein 9","---","---","defense response /// female pregnancy /// female pregnancy","---","extracellular region /// extracellular region /// membrane fraction",null,1.9079,1,0.2489,2,0.0825,0.8604]
[2,2,"206892_AT","AMHR2","anti-Mullerian hormone receptor, type II","---","---","Mullerian duct regression /// protein amino acid phosphorylation /// signal transduction /// sex determination /// sex differentiation /// sex differentiation","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// receptor activity /// receptor activity /// transmembrane receptor protein serine/threonine kinase signaling protein activity /// ATP binding /// kinase activity /// transferase activity /// manganese ion binding /// hormone binding /// metal ion binding","membrane /// integral to membrane","cell growth,differentiation:signal transduction,signaling pathway",2.738,1,0,2,0.3873,0.3907]
[2,3,"211497_X_AT","NKX3-1","NK3 homeobox 1","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// multicellular organismal development /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// sequence-specific DNA binding","nucleus /// nucleus","dna repair,transcription",3.7467,1,0,2,0.4343,0.3303]
[2,4,"216661_X_AT","CYP2C9","Cytochrome P450, family 2, subfamily C, polypeptide 9","---","---","electron transport /// electron transport","monooxygenase activity /// monooxygenase activity /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen /// (S)-limonene 6-monooxygenase activity /// (S)-limonene 7-monooxygenase activity /// heme binding /// metal ion binding","endoplasmic reticulum /// endoplasmic reticulum /// microsome /// microsome /// membrane","transport,ion channel",4.2704,1,0,2,0.3295,0.4704]
[2,5,"215845_X_AT","---","CDNA: FLJ22840 fis, clone KAIA4709","---","---","---","---","---","unknown",2.9066,1,0,0,0.2455,0.5956]
[2,6,"201508_AT","IGFBP4","insulin-like growth factor binding protein 4","Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","skeletal development /// regulation of cell growth /// DNA metabolic process /// signal transduction /// cell proliferation","insulin-like growth factor binding /// growth factor binding","extracellular region","cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",3.3229,1,0.172,2,0.1975,0.6713]
[2,7,"207432_AT","BEST2","bestrophin 2","---","---","transport /// ion transport","ion channel activity /// chloride channel activity /// calcium ion binding /// chloride ion binding","membrane /// integral to membrane","transport,ion channel",3.9455,1,0.0004,2,0.441,0.3219]
[2,8,"219463_AT","C20orf103","chromosome 20 open reading frame 103","---","---","---","---","membrane /// integral to membrane","unknown",2.8735,1,0,2,0.2551,0.5808]
[2,9,"208014_X_AT","RP5-886K2.1","neuronal thread protein AD7c-NTP","---","---","apoptosis /// central nervous system development","---","extracellular space /// integral to membrane","apoptosis",3.1027,1,0,2,0.3514,0.4396]
[2,10,"207718_X_AT","CYP2A13 /// CYP2A6 /// CYP2A7 /// CYP2A7P1","cytochrome P450, family 2, subfamily A, polypeptide 6 /// cytochrome P450, family 2, subfamily A, polypeptide 7 /// cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1 /// cytochrome P450, family 2, subfamily A, polypeptide 13","---","---","electron transport","monooxygenase activity /// monooxygenase activity /// iron ion binding /// coumarin 7-hydroxylase activity /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen /// oxygen binding /// oxygen binding /// heme binding /// metal ion binding /// unspecific monooxygenase activity","endoplasmic reticulum /// microsome /// microsome /// membrane","transport,ion channel",3.4979,1,0,2,0.3294,0.4706]
[2,11,"202827_S_AT","MMP14","matrix metallopeptidase 14 (membrane-inserted)","Matrix_Metalloproteinases","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Matrix_Metalloproteinases/Hs_Matrix_Metalloproteinases.htm","peptidoglycan metabolic process /// proteolysis /// proteolysis","metalloendopeptidase activity /// metalloendopeptidase activity /// calcium ion binding /// protein binding /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// zinc ion binding /// hydrolase activity /// metal ion binding","proteinaceous extracellular matrix /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:proteolysis",2.6722,1,0,0,0.4555,0.3043]
[2,12,"209561_AT","THBS3","thrombospondin 3","Inflammatory_Response_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Inflammatory_Response_Pathway/Hs_Inflammatory_Response_Pathway.htm","cell motility /// cell adhesion /// cell-matrix adhesion","structural molecule activity /// calcium ion binding /// calcium ion binding /// protein binding /// heparin binding","extracellular region /// proteinaceous extracellular matrix","cell adhesion",2.8414,1,0.0007,2,0.406,0.3661]
[2,13,"216207_X_AT","IGKV1D-13","immunoglobulin kappa variable 1D-13","---","---","---","---","---","unknown",3.3468,1,0,2,0.3723,0.4109]
[2,14,"210586_X_AT","RHD","Rh blood group, D antigen","---","---","---","---","integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane /// integral to membrane","unknown",2.8076,1,0,2,0.1355,0.772]
[2,15,"211235_S_AT","ESR1","estrogen receptor 1","Nuclear_Receptors /// Nuclear_Receptors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Nuclear_Receptors/Hs_Nuclear_Receptors.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Nuclear_Receptors/Hs_Nuclear_Receptors.htm","transcription /// transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// signal transduction /// estrogen receptor signaling pathway","DNA binding /// transcription factor activity /// steroid hormone receptor activity /// steroid hormone receptor activity /// steroid hormone receptor activity /// receptor activity /// ligand-dependent nuclear receptor activity /// steroid binding /// protein binding /// zinc ion binding /// lipid binding /// nitric-oxide synthase regulator activity /// estrogen receptor activity /// sequence-specific DNA binding /// metal ion binding","nucleus /// nucleus /// membrane /// chromatin remodeling complex","dna repair,transcription:signal transduction,signaling pathway",2.2253,1,0,0,0.3682,0.4164]
[2,16,"221324_AT","TAS2R1","taste receptor, type 2, member 1","---","---","signal transduction /// G-protein coupled receptor protein signaling pathway /// G-protein coupled receptor protein signaling pathway /// chemosensory behavior /// response to stimulus /// sensory perception of taste","signal transducer activity /// receptor activity /// G-protein coupled receptor activity /// taste receptor activity","membrane /// integral to membrane /// integral to membrane","signal transduction,signaling pathway",3.1551,1,0.0009,2,0.2076,0.6551]
[2,17,"215267_S_AT","SLC8A2","solute carrier family 8 (sodium-calcium exchanger), member 2","---","---","transport /// ion transport /// sodium ion transport /// calcium ion transport /// cell communication","calcium:sodium antiporter activity /// calcium ion binding /// calmodulin binding /// antiporter activity /// sodium ion binding","membrane /// integral to membrane","transport,ion channel",3.8698,1,0,2,0.2777,0.5465]
[2,18,"219741_X_AT","ZNF552","zinc finger protein 552","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription",3.8022,1,0.001,0,0.3641,0.422]
[2,19,"216965_X_AT","SPG20","spastic paraplegia 20 (Troyer syndrome)","---","---","---","---","---","unknown",3.5508,1,0,2,0.2176,0.6393]
[2,20,"212283_AT","AGRN","agrin","---","---","signal transduction /// acetylcholine receptor signaling, muscarinic pathway /// synaptic transmission /// receptor clustering /// receptor clustering /// clustering of voltage-gated sodium channels /// synapse organization and biogenesis","structural constituent of cytoskeleton /// protein binding /// laminin binding","proteinaceous extracellular matrix /// basal lamina /// basal lamina","signal transduction,signaling pathway",3.3304,1,0.3139,2,0.3485,0.4437]
[2,21,"215590_X_AT","---","CDNA: FLJ21966 fis, clone HEP05644","---","---","---","---","---","unknown",4.034,1,0.0006,2,0.5181,0.2335]
[2,22,"208591_S_AT","PDE3B","phosphodiesterase 3B, cGMP-inhibited","---","---","signal transduction /// endocrine pancreas development /// glucose homeostasis /// regulation of insulin secretion","catalytic activity /// 3',5'-cyclic-nucleotide phosphodiesterase activity /// cGMP-inhibited cyclic-nucleotide phosphodiesterase activity /// hydrolase activity","membrane /// integral to membrane","signal transduction,signaling pathway",2.3207,1,0.5337,0,-0.2256,0.6267]
[2,23,"216738_AT","---","CDNA: FLJ20900 fis, clone ADKA03593","---","---","---","---","---","unknown",3.0016,1,0,2,0.3523,0.4383]
[2,24,"208262_X_AT","MEFV","Mediterranean fever","---","---","inflammatory response /// inflammatory response","actin binding /// actin binding /// protein binding /// zinc ion binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus /// cytoplasm /// cytoskeleton /// microtubule /// microtubule associated complex",null,3.6064,1,0,4,0.4317,0.3334]
[2,25,"207644_AT","FOXH1","forkhead box H1","TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","transcription /// regulation of transcription, DNA-dependent /// transforming growth factor beta receptor signaling pathway /// positive regulation of transcription from RNA polymerase II promoter","DNA binding /// transcription factor activity /// transcription activator activity /// protein domain specific binding /// sequence-specific DNA binding /// sequence-specific DNA binding /// SMAD binding","nucleus /// nucleus /// activin responsive factor complex","dna repair,transcription:signal transduction,signaling pathway",3.1754,1,0.6615,-2,0.1014,0.8288]
[2,26,"208332_AT","PRY","PTPN13-like, Y-linked","---","---","---","---","---","unknown",2.2563,1,0,2,0.3293,0.4707]
[2,27,"205932_S_AT","MSX1","msh homeobox 1","---","---","negative regulation of transcription from RNA polymerase II promoter /// skeletal development /// transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development /// muscle development /// organ morphogenesis /// embryonic limb morphogenesis /// forebrain development /// midbrain development /// regulation of transcription /// negative regulation of transcription, DNA-dependent","DNA binding /// transcription factor activity /// protein binding /// transcription repressor activity /// sequence-specific DNA binding","nucleus","dna repair,transcription",0.4731,1,0,0,-0.064,0.8916]
[2,28,"217051_S_AT","SS18","synovial sarcoma translocation, chromosome 18","---","---","---","nutrient reservoir activity","nucleus","unknown",2.4477,1,0.2469,2,0.1755,0.7066]
[2,29,"214646_AT","HIST1H3J","Histone cluster 1, H3j","---","---","---","---","---","unknown",0.8272,1,0.255,0,-0.1378,0.7683]
[2,30,"215826_X_AT","BC37295_3","hypothetical BC37295_3","---","---","---","nucleic acid binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus","unknown",3.3754,1,0,2,0.399,0.3752]
[2,31,"207537_AT","PFKFB1","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1","---","---","fructose 2,6-bisphosphate metabolic process /// fructose 2,6-bisphosphate metabolic process /// gluconeogenesis /// glycolysis /// metabolic process","nucleotide binding /// catalytic activity /// 6-phosphofructo-2-kinase activity /// 6-phosphofructo-2-kinase activity /// fructose-2,6-bisphosphate 2-phosphatase activity /// fructose-2,6-bisphosphate 2-phosphatase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// hydrolase activity /// identical protein binding","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex","biosynthesis,metabolism,metabolic process,biosynthetic process",3.8235,1,0.0005,2,0.4992,0.2541]
[2,32,"215019_X_AT","ZNF528","zinc finger protein 528","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription",3.1068,-1,1.4001,2,0.6486,0.1151]
[2,33,"205902_AT","KCNN3","potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3","---","---","transport /// ion transport /// potassium ion transport /// potassium ion transport /// synaptic transmission /// nervous system development","ion channel activity /// calmodulin binding /// calcium-activated potassium channel activity /// calcium-activated potassium channel activity /// small conductance calcium-activated potassium channel activity","membrane fraction /// voltage-gated potassium channel complex /// membrane /// integral to membrane","transport,ion channel",4.3876,1,0.0005,2,0.3649,0.4209]
[2,34,"214236_AT","CDC27","Cell division cycle 27 homolog (S. cerevisiae)","---","---","mitotic metaphase/anaphase transition /// mitotic metaphase/anaphase transition /// cell proliferation","binding /// protein binding","anaphase-promoting complex /// cytoplasm /// centrosome /// centrosome /// spindle /// spindle microtubule","cell cycle,proliferation",1.4904,1,0.912,0,-0.2077,0.655]
[2,35,"217001_X_AT","HLA-DOA","major histocompatibility complex, class II, DO alpha","---","---","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II /// immune response /// antigen processing and presentation","MHC class II receptor activity","plasma membrane /// membrane /// integral to membrane /// MHC class II protein complex","immune response",3.8545,1,0.0008,2,0.4543,0.3058]
[2,36,"209594_X_AT","PSG9","pregnancy specific beta-1-glycoprotein 9","---","---","defense response /// female pregnancy /// female pregnancy","---","extracellular region /// extracellular region /// membrane fraction",null,3.8325,1,0.0002,2,0.3165,0.4892]
[2,37,"202694_AT","STK17A","serine/threonine kinase 17a","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// apoptosis /// induction of apoptosis /// protein kinase cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// ATP binding /// ATP binding /// kinase activity /// transferase activity","nucleus","apoptosis",2.3371,-1,1.3247,2,0.6554,0.11]
[2,38,"205267_AT","POU2AF1","POU class 2 associating factor 1","---","---","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// humoral immune response","DNA binding /// transcription cofactor activity /// transcription coactivator activity /// protein binding","---","dna repair,transcription:immune response",2.5892,1,1.8755,-2,-0.4552,0.3047]
[2,39,"207554_X_AT","TBXA2R","thromboxane A2 receptor","GPCRDB_Class_A_Rhodopsin-like /// Small_ligand_GPCRs","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Class_A_Rhodopsin-like/Hs_GPCRDB_Class_A_Rhodopsin-like.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Small_ligand_GPCRs/Hs_Small_ligand_GPCRs.htm","muscle contraction /// signal transduction /// G-protein coupled receptor protein signaling pathway /// G-protein coupled receptor protein signaling pathway /// respiratory gaseous exchange","rhodopsin-like receptor activity /// signal transducer activity /// receptor activity /// G-protein coupled receptor activity /// thromboxane receptor activity /// thromboxane A2 receptor activity","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","signal transduction,signaling pathway",4.7956,1,0,2,0.5055,0.2471]
[2,40,"221731_X_AT","VCAN","versican","---","---","cell adhesion /// cell adhesion /// multicellular organismal development /// cell recognition","calcium ion binding /// sugar binding /// glycosaminoglycan binding /// hyaluronic acid binding /// hyaluronic acid binding","proteinaceous extracellular matrix /// proteinaceous extracellular matrix /// membrane /// integral to membrane","cell adhesion",4.0309,1,0,2,0.2902,0.5278]
[2,41,"204620_S_AT","VCAN","versican","---","---","cell adhesion /// cell adhesion /// multicellular organismal development /// cell recognition","calcium ion binding /// sugar binding /// glycosaminoglycan binding /// hyaluronic acid binding /// hyaluronic acid binding","proteinaceous extracellular matrix /// proteinaceous extracellular matrix /// membrane /// integral to membrane","cell adhesion",3.4235,1,0.0001,2,0.3856,0.3929]
[2,42,"212488_AT","COL5A1","collagen, type V, alpha 1","---","---","phosphate transport /// cell adhesion","structural molecule activity /// extracellular matrix structural constituent /// heparin binding","proteinaceous extracellular matrix /// collagen /// collagen type V /// cytoplasm","cell adhesion:transport,ion channel",1.1566,1,0.8012,0,-0.1657,0.7226]
[]
[null,null,3]
[3,1,"213793_S_AT","HOMER1","homer homolog 1 (Drosophila)","---","---","metabotropic glutamate receptor, phospholipase C activating pathway /// synaptic transmission","protein binding","cytoplasm /// integral to plasma membrane /// membrane /// cell junction /// synapse",null,7.9798,-1,0,2,-0.5182,0.2334]
[3,2,"212893_AT","ZZZ3","zinc finger, ZZ-type containing 3","---","---","transcription /// regulation of transcription, DNA-dependent","DNA binding /// zinc ion binding /// metal ion binding","nucleus",null,5.5959,1,0,2,-0.2504,0.5881]
[3,3,"203247_S_AT","ZNF24","zinc finger protein 24","---","---","transcription /// regulation of transcription, DNA-dependent /// negative regulation of transcription","nucleic acid binding /// DNA binding /// DNA binding /// transcription factor activity /// protein binding /// zinc ion binding /// zinc ion binding /// transcription repressor activity /// metal ion binding","intracellular /// nucleus /// nucleus",null,7.5052,1,0,2,-0.5766,0.1754]
[3,4,"217985_S_AT","BAZ1A","bromodomain adjacent to zinc finger domain, 1A","---","---","transcription /// regulation of transcription, DNA-dependent","protein binding /// zinc ion binding /// metal ion binding","---",null,3.6862,-1,0,0,-0.3025,0.5097]
[3,5,"213668_S_AT","SOX4","SRY (sex determining region Y)-box 4","---","---","transcription /// regulation of transcription, DNA-dependent /// exocrine pancreas development","DNA binding /// transcription factor activity","nucleus",null,8.0824,1,0,2,-0.3984,0.376]
[3,6,"212888_AT","DICER1","Dicer1, Dcr-1 homolog (Drosophila)","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","RNA processing /// stem cell maintenance /// lung development /// embryonic limb morphogenesis /// RNA interference, production of siRNA /// RNA interference, targeting of mRNA for destruction /// embryonic hindlimb morphogenesis /// miRNA-mediated gene silencing, production of miRNAs /// branching morphogenesis of a tube","nucleotide binding /// nucleic acid binding /// RNA binding /// double-stranded RNA binding /// double-stranded RNA binding /// helicase activity /// nuclease activity /// endonuclease activity /// ribonuclease III activity /// ribonuclease III activity /// protein binding /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","intracellular /// intracellular",null,7.6201,1,1.872,2,-0.1963,0.6731]
[3,7,"214670_AT","ZKSCAN1","zinc finger with KRAB and SCAN domains 1","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// transcription factor activity /// transcription factor activity /// zinc ion binding /// metal ion binding","intracellular /// nucleus /// nucleus",null,9.087,1,0,2,-0.1487,0.7503]
[3,8,"212150_AT","KIAA0143","KIAA0143 protein","---","---","---","---","intracellular /// plasma membrane /// membrane",null,4.6833,1,0,2,-0.362,0.4249]
[3,9,"202900_S_AT","NUP88","nucleoporin 88kDa","---","---","protein targeting /// transport /// protein transport /// mRNA transport","transporter activity","nuclear pore /// nuclear pore",null,6.5105,1,0,2,-0.1128,0.8097]
[3,10,"201151_S_AT","MBNL1","muscleblind-like (Drosophila)","---","---","in utero embryonic development /// nervous system development /// muscle development /// embryonic limb morphogenesis /// myoblast differentiation","nucleic acid binding /// RNA binding /// double-stranded RNA binding /// zinc ion binding /// metal ion binding","nucleus /// cytoplasm",null,7.6562,-1,0,0,-0.7865,0.0359]
[3,11,"218331_S_AT","C10orf18","chromosome 10 open reading frame 18","---","---","---","---","---",null,7.4826,1,0,2,-0.4123,0.358]
[3,12,"208810_AT","DNAJB6 /// LOC387820","DnaJ (Hsp40) homolog, subfamily B, member 6 /// similar to DnaJ (Hsp40) homolog, subfamily B, member 6 isoform a","---","---","protein folding /// protein folding /// response to unfolded protein /// negative regulation of caspase activity /// intermediate filament organization","ATPase activator activity /// protein binding /// heat shock protein binding /// heat shock protein binding /// chaperone binding","nucleus /// cytoplasm /// perinuclear region of cytoplasm",null,8.7154,1,1.3498,2,-0.5217,0.2298]
[3,13,"212536_AT","ATP11B","ATPase, Class VI, type 11B","---","---","transport /// ion transport /// metabolic process /// phospholipid transport /// aminophospholipid transport","nucleotide binding /// magnesium ion binding /// catalytic activity /// phospholipid-translocating ATPase activity /// phospholipid-translocating ATPase activity /// binding /// ATP binding /// ion transmembrane transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// metal ion binding","nuclear inner membrane /// membrane /// integral to membrane",null,6.7858,1,1.2924,2,-0.4777,0.2783]
[3,14,"209187_AT","DR1","down-regulator of transcription 1, TBP-binding (negative cofactor 2)","---","---","negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent","DNA binding /// DNA binding /// transcription corepressor activity /// transcription factor binding /// sequence-specific DNA binding","intracellular /// nucleus",null,9.6828,1,1.3104,2,-0.6429,0.1193]
[3,15,"210719_S_AT","HMG20B","high-mobility group 20B","---","---","establishment and/or maintenance of chromatin architecture /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// tRNA aminoacylation for protein translation /// cell cycle /// chromatin modification","nucleotide binding /// DNA binding /// DNA binding /// transcription factor activity /// aminoacyl-tRNA ligase activity /// ATP binding","chromatin /// nucleus /// nucleus /// cytoplasm",null,4.4884,1,0,2,-0.2478,0.5921]
[3,16,"209027_S_AT","ABI1","abl-interactor 1","---","---","transmembrane receptor protein tyrosine kinase signaling pathway /// negative regulation of cell proliferation","protein binding /// cytoskeletal protein binding","soluble fraction /// cytoplasm /// endoplasmic reticulum /// cytosol /// cytoskeleton /// synaptosome /// cell junction /// cell projection /// synapse",null,8.1317,1,1.9016,0,-0.5852,0.1675]
[3,17,"212751_AT","UBE2N","ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)","---","---","double-strand break repair via homologous recombination /// DNA double-strand break processing /// DNA repair /// regulation of DNA repair /// postreplication repair /// protein modification process /// protein modification process /// proteolysis /// ubiquitin cycle /// ubiquitin cycle /// response to DNA damage stimulus /// protein ubiquitination /// protein ubiquitination /// histone ubiquitination /// positive regulation of histone modification /// positive regulation of I-kappaB kinase/NF-kappaB cascade /// positive regulation of DNA repair /// T cell receptor signaling pathway /// activation of NF-kappaB transcription factor /// positive regulation of ubiquitin ligase activity","ubiquitin-protein ligase activity /// protein binding /// ligase activity /// small conjugating protein ligase activity /// ubiquitin binding","nucleus /// cytoplasm /// UBC13-MMS2 complex",null,12.7109,1,0,2,-0.3513,0.4398]
[3,18,"210567_S_AT","SKP2","S-phase kinase-associated protein 2 (p45)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of progression through cell cycle /// G1/S transition of mitotic cell cycle /// ubiquitin cycle /// cell proliferation","protein binding /// protein binding","---",null,6.5205,1,0,2,0.1347,0.7735]
[3,19,"213145_AT","FBXL14","F-box and leucine-rich repeat protein 14","---","---","ubiquitin cycle","protein binding","---",null,9.0262,1,0,0,-0.5784,0.1737]
[3,20,"209155_S_AT","NT5C2","5'-nucleotidase, cytosolic II","---","---","---","catalytic activity /// 5'-nucleotidase activity /// 5'-nucleotidase activity /// hydrolase activity","cytoplasm /// cytosol",null,7.8085,1,0,3,-0.6988,0.0807]
[3,21,"210793_S_AT","NUP98","nucleoporin 98kDa","---","---","protein import into nucleus, docking /// protein import into nucleus, docking /// DNA replication /// protein targeting /// transport /// nucleocytoplasmic transport /// nuclear pore organization and biogenesis /// protein transport /// mRNA transport","transporter activity /// protein binding /// protein binding /// zinc ion binding /// structural constituent of nuclear pore /// metal ion binding","nuclear pore /// nuclear pore /// nuclear pore /// nucleoplasm",null,5.5596,1,0,2,-0.5317,0.2193]
[3,22,"201133_S_AT","PJA2","praja 2, RING-H2 motif containing","---","---","ubiquitin cycle","protein binding /// zinc ion binding /// ligase activity /// metal ion binding","cytoplasm /// endoplasmic reticulum /// membrane /// cell junction /// synapse",null,7.2166,1,0,0,-0.4362,0.3279]
[3,23,"211063_S_AT","NCK1","NCK adaptor protein 1","---","---","actin filament organization /// signal complex assembly /// intracellular signaling cascade /// cell migration /// lamellipodium biogenesis /// positive regulation of actin filament polymerization /// positive regulation of T cell proliferation /// T cell activation","receptor binding /// protein binding /// protein binding /// cytoskeletal adaptor activity /// receptor signaling complex scaffold activity","cytoplasm /// cytoplasm /// cytoplasm /// vesicle membrane",null,10.9584,1,0,2,-0.6118,0.1443]
[3,24,"209142_S_AT","UBE2G1","ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)","---","---","protein modification process /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle","ubiquitin-protein ligase activity /// ligase activity /// small conjugating protein ligase activity","---",null,7.6071,1,0,2,-0.4793,0.2765]
[3,25,"222163_S_AT","SPATA5L1","spermatogenesis associated 5-like 1","---","---","cell division","nucleotide binding /// ATP binding /// nucleoside-triphosphatase activity","---",null,6.8505,1,0,0,-0.2632,0.5684]
[3,26,"213026_AT","ATG12","ATG12 autophagy related 12 homolog (S. cerevisiae)","---","---","autophagic vacuole formation /// protein modification process /// ubiquitin cycle /// autophagy /// autophagy /// apoptosis","protein binding","cytoplasm /// cytoplasm",null,11.0852,1,0,2,-0.6261,0.1325]
[3,27,"208859_S_AT","ATRX /// LOC728849","alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) /// similar to transcriptional regulator ATRX isoform 1","---","---","DNA repair /// DNA repair /// DNA methylation /// DNA recombination /// regulation of transcription, DNA-dependent /// response to DNA damage stimulus /// chromosome organization and biogenesis (sensu Eukaryota) /// sensory perception of sound","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA helicase activity /// transcription factor activity /// helicase activity /// helicase activity /// protein binding /// ATP binding /// zinc ion binding /// hydrolase activity /// metal ion binding","nucleus /// nuclear heterochromatin",null,8.7988,1,0,1,-0.5882,0.1648]
[3,28,"201862_S_AT","LRRFIP1","leucine rich repeat (in FLII) interacting protein 1","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// negative regulation of transcription","nucleotide binding /// nucleic acid binding /// DNA binding /// RNA polymerase II transcription factor activity /// RNA binding /// double-stranded RNA binding /// transcription repressor activity","nucleus /// nucleus /// cytoplasm /// cytoplasm /// cytoskeleton",null,9.9725,-1,0.097,2,-0.7358,0.0594]
[3,29,"212368_AT","ZNF292","zinc finger protein 292","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular",null,9.322,1,0,3,-0.322,0.4812]
[3,30,"212585_AT","OSBPL8","oxysterol binding protein-like 8","---","---","transport /// lipid transport /// steroid metabolic process","---","---",null,8.2103,-1,1.5388,2,-0.3797,0.4008]
[3,31,"203680_AT","PRKAR2B","protein kinase, cAMP-dependent, regulatory, type II, beta","Calcium_regulation_in_cardiac_cells /// G_Protein_Signaling /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","protein amino acid phosphorylation /// fatty acid metabolic process /// signal transduction /// intracellular signaling cascade /// learning","nucleotide binding /// cAMP-dependent protein kinase regulator activity /// cAMP-dependent protein kinase regulator activity /// kinase activity /// cAMP binding","cAMP-dependent protein kinase complex",null,8.4907,1,1.8767,3,-0.8271,0.0217]
[3,32,"213656_S_AT","KLC1","kinesin light chain 1","---","---","---","motor activity /// motor activity /// microtubule motor activity /// binding /// protein binding /// protein binding","cytosol /// kinesin complex /// kinesin complex /// kinesin complex /// microtubule",null,7.0173,-1,1.2643,2,-0.0105,0.9821]
[3,33,"218919_AT","ZFAND1","zinc finger, AN1-type domain 1","---","---","---","zinc ion binding /// metal ion binding","---",null,10.6638,-1,0.5083,3,-0.5144,0.2375]
[3,34,"208783_S_AT","CD46","CD46 molecule, complement regulatory protein","---","---","immune response /// complement activation /// complement activation, classical pathway /// single fertilization /// innate immune response","receptor activity","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane",null,6.6212,-1,0,2,-0.2762,0.5487]
[3,35,"212248_AT","MTDH","CDNA FLJ41088 fis, clone ASTRO2002459 /// Metadherin","---","---","---","---","endoplasmic reticulum /// tight junction /// membrane /// integral to membrane /// cell junction",null,9.2508,1,0,2,-0.248,0.5918]
[3,36,"203102_S_AT","MGAT2","mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase","---","---","protein amino acid N-linked glycosylation /// oligosaccharide metabolic process /// oligosaccharide biosynthetic process /// protein amino acid N-linked glycosylation via asparagine","alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity /// alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups","membrane fraction /// Golgi apparatus /// Golgi stack /// membrane /// integral to membrane",null,9.093,1,1.2882,0,-0.6925,0.0846]
[3,37,"201877_S_AT","PPP2R5C","protein phosphatase 2, regulatory subunit B', gamma isoform","Glycogen_Metabolism /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycogen_Metabolism/Hs_Glycogen_Metabolism.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","signal transduction /// signal transduction /// protein processing","protein binding /// peptidase activity /// protein phosphatase type 2A regulator activity /// protein phosphatase type 2A regulator activity","protein phosphatase type 2A complex /// protein phosphatase type 2A complex /// nucleus /// integral to membrane",null,13.3736,1,0.4439,1,-0.6949,0.0831]
[3,38,"208943_S_AT","TLOC1","translocation protein 1","---","---","protein targeting /// cotranslational protein targeting to membrane /// transport /// protein transport","receptor activity /// protein transporter activity","endoplasmic reticulum /// endoplasmic reticulum /// membrane /// integral to membrane /// integral to membrane",null,7.597,1,0.352,-1,-0.4844,0.2706]
[3,39,"201123_S_AT","EIF5A","eukaryotic translation initiation factor 5A","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// regulation of translational initiation /// viral genome replication","translation initiation factor activity /// translation factor activity, nucleic acid binding","cytoplasm",null,14.0396,1,0.0137,2,-0.0675,0.8857]
[3,40,"201916_S_AT","SEC63","SEC63 homolog (S. cerevisiae)","---","---","protein folding /// protein targeting to membrane /// transport /// protein transport","receptor activity /// heat shock protein binding /// unfolded protein binding","endoplasmic reticulum /// endoplasmic reticulum /// microsome /// membrane /// integral to membrane",null,11.7406,1,0.9018,2,-0.4306,0.3348]
[3,41,"208924_AT","RNF11","ring finger protein 11","---","---","ubiquitin-dependent protein catabolic process /// protein ubiquitination during ubiquitin-dependent protein catabolic process","DNA binding /// protein binding /// protein binding /// protein binding /// zinc ion binding /// zinc ion binding /// metal ion binding","ubiquitin ligase complex /// ubiquitin ligase complex",null,7.9702,1,1.106,5,-0.0772,0.8694]
[3,42,"204897_AT","PTGER4","prostaglandin E receptor 4 (subtype EP4)","GPCRDB_Class_A_Rhodopsin-like /// Prostaglandin_synthesis_regulation /// Small_ligand_GPCRs","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Class_A_Rhodopsin-like/Hs_GPCRDB_Class_A_Rhodopsin-like.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Prostaglandin_synthesis_regulation/Hs_Prostaglandin_synthesis_regulation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Small_ligand_GPCRs/Hs_Small_ligand_GPCRs.htm","immune response /// signal transduction /// G-protein coupled receptor protein signaling pathway /// G-protein signaling, coupled to cAMP nucleotide second messenger /// regulation of ossification","rhodopsin-like receptor activity /// signal transducer activity /// receptor activity /// G-protein coupled receptor activity /// prostaglandin receptor activity /// prostaglandin E receptor activity /// prostaglandin E receptor activity","membrane /// integral to membrane /// integral to membrane",null,12.0211,-1,0.709,3,-0.0142,0.976]
[3,43,"204847_AT","ZBTB11","zinc finger and BTB domain containing 11","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// protein binding /// zinc ion binding /// metal ion binding","intracellular",null,13.2075,-1,0.0145,0,-0.2911,0.5265]
[3,44,"218932_AT","C1orf181","chromosome 1 open reading frame 181","---","---","---","zinc ion binding /// metal ion binding","---",null,8.6031,-1,0,0,-0.118,0.8011]
[3,45,"221517_S_AT","MED17","mediator complex subunit 17","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// regulation of transcription from RNA polymerase II promoter /// transcription initiation from RNA polymerase II promoter /// transcription initiation from RNA polymerase II promoter /// steroid hormone receptor signaling pathway /// androgen receptor signaling pathway /// positive regulation of transcription from RNA polymerase II promoter","transcription cofactor activity /// transcription coactivator activity /// transcription coactivator activity /// receptor activity /// receptor activity /// protein binding /// RNA polymerase II transcription mediator activity /// transcription activator activity /// ligand-dependent nuclear receptor transcription coactivator activity /// transcription regulator activity /// vitamin D receptor binding /// thyroid hormone receptor binding","mediator complex /// nucleus /// transcription factor complex",null,6.5859,-1,0,0,0.0056,0.9905]
[3,46,"219200_AT","FASTKD3","FAST kinase domains 3","---","---","apoptosis","protein kinase activity /// ATP binding","---",null,9.8065,1,0,0,-0.3304,0.4692]
[3,47,"203739_AT","ZNF217","zinc finger protein 217","---","---","transcription /// transcription, DNA-dependent /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// transcription factor activity /// zinc ion binding /// metal ion binding","intracellular",null,12.231,1,0,0,-0.8231,0.0229]
[3,48,"219161_S_AT","CKLF","chemokine-like factor","---","---","chemotaxis /// cell proliferation /// neutrophil chemotaxis /// secretory pathway /// macrophage chemotaxis /// lymphocyte chemotaxis","cytokine activity /// chemokine activity","extracellular region /// extracellular space /// membrane /// integral to membrane /// integral to membrane",null,11.8495,1,1.8642,0,-0.7499,0.0522]
[3,49,"213111_AT","PIP5K3","phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III","---","---","protein folding /// intracellular signaling cascade /// intracellular signaling cascade /// calcium-mediated signaling /// cellular protein metabolic process /// phosphatidylinositol metabolic process","nucleotide binding /// protein binding /// protein binding /// ATP binding /// zinc ion binding /// kinase activity /// phosphatidylinositol phosphate kinase activity /// 1-phosphatidylinositol-4-phosphate 5-kinase activity /// 1-phosphatidylinositol-4-phosphate 5-kinase activity /// transferase activity /// metal ion binding","endosome /// membrane /// lipid raft",null,29.6539,1,1.8277,0,-0.7446,0.0549]
[3,50,"205590_AT","RASGRP1","RAS guanyl releasing protein 1 (calcium and DAG-regulated)","---","---","signal transduction /// intracellular signaling cascade /// small GTPase mediated signal transduction /// Ras protein signal transduction /// regulation of small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity /// guanyl-nucleotide exchange factor activity /// Ras guanyl-nucleotide exchange factor activity /// calcium ion binding /// calcium ion binding /// protein binding /// zinc ion binding /// lipid binding /// metal ion binding","intracellular /// membrane fraction",null,8.3163,1,0,0,-0.5909,0.1624]
[3,51,"213019_AT","RANBP6","RAN binding protein 6","---","---","transport /// protein transport","binding","cytoplasm",null,8.026,1,0,0,-0.3283,0.4722]
[3,52,"208056_S_AT","CBFA2T3","core-binding factor, runt domain, alpha subunit 2; translocated to, 3","---","---","regulation of transcription, DNA-dependent /// cell proliferation /// granulocyte differentiation","transcription factor activity /// protein binding /// zinc ion binding","nucleus",null,8.1588,-1,0,0,-0.9521,0.0009]
[3,53,"221931_S_AT","SEH1L","SEH1-like (S. cerevisiae)","---","---","protein targeting /// transport /// protein transport /// mRNA transport","---","nuclear pore",null,11.7604,1,1.4854,0,-0.0929,0.8429]
[3,54,"201034_AT","ADD3","adducin 3 (gamma)","---","---","---","structural constituent of cytoskeleton /// calmodulin binding /// metal ion binding","cytoplasm /// cytoskeleton /// membrane /// membrane",null,12.1946,1,0,0,-0.9274,0.0026]
[3,55,"212413_AT","2008-09-06","septin 6","---","---","cytokinesis /// cell cycle /// cell division","nucleotide binding /// protein binding /// protein binding /// GTP binding /// GTP binding","---",null,9.4652,1,0.8767,0,-0.4784,0.2775]
[3,56,"221020_S_AT","SLC25A32","solute carrier family 25, member 32","---","---","transport /// folic acid transport","transporter activity /// binding /// folic acid transporter activity","mitochondrion /// mitochondrial inner membrane /// mitochondrial inner membrane /// membrane /// integral to membrane",null,10.6869,1,0,0,-0.1587,0.734]
[3,57,"205000_AT","DDX3Y","DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked","---","---","---","nucleotide binding /// nucleic acid binding /// DNA binding /// RNA binding /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","cytoplasm",null,11.4562,-1,0,0,-0.1831,0.6943]
[3,58,"209146_AT","SC4MOL","sterol-C4-methyl oxidase-like","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","fatty acid metabolic process /// steroid biosynthetic process /// metabolic process /// steroid metabolic process /// lipid biosynthetic process /// sterol biosynthetic process","C-4 methylsterol oxidase activity /// catalytic activity /// iron ion binding /// oxidoreductase activity","endoplasmic reticulum /// endoplasmic reticulum /// plasma membrane /// membrane /// integral to membrane /// integral to membrane",null,16.4601,-1,0,0,0.1813,0.6973]
[]
[null,null,4]
[4,1,"201478_S_AT","DKC1","dyskeratosis congenita 1, dyskerin","---","---","regulation of progression through cell cycle /// rRNA processing /// rRNA processing /// RNA processing /// RNA processing /// telomere maintenance via telomerase /// cell proliferation /// ribosome biogenesis and assembly","telomerase activity /// RNA binding /// RNA binding /// tRNA-pseudouridine synthase activity /// isomerase activity","nucleus /// nucleoplasm /// telomerase holoenzyme complex /// nucleolus /// ribonucleoprotein complex","cell cycle,proliferation",0.6612,-1,1.3248,-3,0.0145,0.9755]
[4,2,"210968_S_AT","RTN4","reticulon 4","---","---","apoptosis /// negative regulation of anti-apoptosis /// negative regulation of anti-apoptosis /// negative regulation of axon extension /// regulation of apoptosis","protein binding /// protein binding","nuclear envelope /// endoplasmic reticulum /// endoplasmic reticulum /// membrane /// integral to membrane /// integral to endoplasmic reticulum membrane /// integral to endoplasmic reticulum membrane","apoptosis",0.1996,-1,0,-3,-0.72,0.068]
[4,3,"212971_AT","CARS","cysteinyl-tRNA synthetase","---","---","translation /// cysteinyl-tRNA aminoacylation","tRNA binding /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cysteine-tRNA ligase activity /// receptor activity /// ATP binding /// zinc ion binding /// ligase activity /// metal ion binding","soluble fraction /// cytoplasm /// cytoplasm",null,0.579,-1,1.3776,-3,-0.0587,0.9005]
[4,4,"200751_S_AT","HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","nuclear mRNA splicing, via spliceosome /// mRNA processing /// RNA splicing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// protein binding /// identical protein binding","spliceosome /// spliceosome /// ribonucleoprotein complex",null,1.7902,-1,0,-1,-0.0208,0.9647]
[4,5,"201475_X_AT","MARS","methionyl-tRNA synthetase","---","---","translation /// tRNA aminoacylation for protein translation /// methionyl-tRNA aminoacylation","tRNA binding /// nucleotide binding /// RNA binding /// aminoacyl-tRNA ligase activity /// methionine-tRNA ligase activity /// methionine-tRNA ligase activity /// protein binding /// ATP binding /// ligase activity","soluble fraction /// cytoplasm /// cytoplasm",null,2.389,1,0,0,0.7356,0.0595]
[4,6,"201183_S_AT","CHD4","chromodomain helicase DNA binding protein 4","---","---","chromatin assembly or disassembly /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// chromosome organization and biogenesis (sensu Eukaryota) /// chromatin modification","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA binding /// chromatin binding /// ATP-dependent DNA helicase activity /// helicase activity /// protein binding /// protein binding /// ATP binding /// ATP-dependent helicase activity /// transcription factor binding /// zinc ion binding /// zinc ion binding /// hydrolase activity /// metal ion binding","chromatin /// nucleus","dna repair,transcription",1.028,-1,1.303,0,-0.0729,0.8765]
[4,7,"201066_AT","CYC1","cytochrome c-1","---","---","electron transport /// transport","iron ion binding /// electron carrier activity /// heme binding /// electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity /// metal ion binding","mitochondrion /// mitochondrion /// mitochondrial inner membrane /// mitochondrial respiratory chain /// membrane /// integral to membrane","transport,ion channel",2.2783,-1,0,-1,0.4893,0.2651]
[4,8,"218237_S_AT","SLC38A1","solute carrier family 38, member 1","---","---","neutral amino acid transport","sodium:amino acid symporter activity /// neutral amino acid transmembrane transporter activity","integral to membrane","transport,ion channel",0.7724,-1,1.0432,-2,-0.2515,0.5864]
[4,9,"200027_AT","NARS","asparaginyl-tRNA synthetase","---","---","translation /// tRNA aminoacylation for protein translation /// asparaginyl-tRNA aminoacylation /// aspartyl-tRNA aminoacylation","nucleotide binding /// nucleic acid binding /// aminoacyl-tRNA ligase activity /// aspartate-tRNA ligase activity /// asparagine-tRNA ligase activity /// asparagine-tRNA ligase activity /// protein binding /// ATP binding /// ligase activity","soluble fraction /// cytoplasm /// cytoplasm",null,0.6083,-1,1.9629,0,-0.0034,0.9941]
[4,10,"209608_S_AT","ACAT2","acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)","---","---","lipid metabolic process","acetyl-CoA C-acetyltransferase activity /// protein binding /// acyltransferase activity /// transferase activity","cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",2.1007,-1,0,-3,0.6509,0.1133]
[4,11,"217957_AT","C16orf80","chromosome 16 open reading frame 80","---","---","multicellular organismal development","---","---",null,1.0548,-1,0.3385,0,0.1218,0.7947]
[4,12,"208910_S_AT","C1QBP","complement component 1, q subcomponent binding protein","---","---","immune response","protein binding","mitochondrion /// mitochondrial matrix /// plasma membrane /// membrane","immune response",2.0163,-1,0,-3,0.0672,0.8861]
[4,13,"207121_S_AT","MAPK6","mitogen-activated protein kinase 6","Integrin-mediated_cell_adhesion_KEGG /// Integrin-mediated_cell_adhesion_KEGG /// S1P_Signaling /// S1P_Signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_S1P_Signaling/Hs_S1P_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_S1P_Signaling/Hs_S1P_Signaling.htm","protein amino acid phosphorylation /// protein amino acid phosphorylation /// cell cycle /// signal transduction","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// MAP kinase activity /// ATP binding /// kinase activity /// transferase activity","---","cell cycle,proliferation:signal transduction,signaling pathway",1.6002,-1,1.6174,-2,0.1758,0.7061]
[4,14,"212048_S_AT","YARS","tyrosyl-tRNA synthetase","---","---","translation /// tRNA aminoacylation for protein translation /// tyrosyl-tRNA aminoacylation /// tyrosyl-tRNA aminoacylation /// apoptosis /// cell motility","tRNA binding /// nucleotide binding /// RNA binding /// aminoacyl-tRNA ligase activity /// tyrosine-tRNA ligase activity /// tyrosine-tRNA ligase activity /// signal transducer activity /// interleukin-8 receptor binding /// protein binding /// ATP binding /// ligase activity","extracellular space /// soluble fraction /// cytoplasm /// cytoplasm","apoptosis",1.7223,-1,0,-3,0.2746,0.5511]
[4,15,"201210_AT","DDX3X","DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked","---","---","---","nucleotide binding /// nucleic acid binding /// DNA binding /// RNA binding /// ATP-dependent RNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","nucleus /// cytoplasm /// cytoplasm","unknown",0.6354,-1,1.7554,-2,-0.1888,0.6852]
[4,16,"201263_AT","TARS","threonyl-tRNA synthetase","---","---","translation /// tRNA aminoacylation for protein translation /// threonyl-tRNA aminoacylation","nucleotide binding /// aminoacyl-tRNA ligase activity /// threonine-tRNA ligase activity /// protein binding /// ATP binding /// ligase activity","soluble fraction /// cytoplasm /// cytoplasm",null,1.3511,-1,0,-3,0.0672,0.8861]
[4,17,"202431_S_AT","MYC","v-myc myelocytomatosis viral oncogene homolog (avian)","Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// Wnt_signaling /// Wnt_signaling /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","release of cytochrome c from mitochondria /// DNA fragmentation during apoptosis /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// cellular iron ion homeostasis /// caspase activation /// cell cycle arrest /// cell proliferation /// positive regulation of cell proliferation /// induction of apoptosis by intracellular signals /// activation of pro-apoptotic gene products /// negative regulation of survival gene product activity /// response to radiation /// regulation of cell proliferation /// regulation of apoptosis /// regulation of transcription","DNA binding /// DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// protein binding /// protein binding /// transcription regulator activity","nucleus /// nucleus /// nucleus /// nucleus /// spindle","dna repair,transcription:apoptosis:cell cycle,proliferation",0.6894,-1,0,-3,-0.3609,0.4264]
[4,18,"200831_S_AT","SCD","stearoyl-CoA desaturase (delta-9-desaturase)","Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","lipid metabolic process /// fatty acid biosynthetic process /// lipid biosynthetic process","stearoyl-CoA 9-desaturase activity /// stearoyl-CoA 9-desaturase activity /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",2.7443,1,0,0,0.5207,0.2308]
[4,19,"204170_S_AT","CKS2","CDC28 protein kinase regulatory subunit 2","---","---","regulation of cyclin-dependent protein kinase activity /// cell cycle /// cell cycle /// spindle organization and biogenesis /// meiosis I /// cell proliferation /// phosphoinositide-mediated signaling /// cell division","kinase activity /// cyclin-dependent protein kinase regulator activity","---","cell cycle,proliferation",2.3519,-1,0.2155,-3,-0.9305,0.0024]
[4,20,"202207_AT","ARL4C","ADP-ribosylation factor-like 4C","---","---","small GTPase mediated signal transduction","nucleotide binding /// GTPase activity /// GTP binding","intracellular /// nucleus","signal transduction,signaling pathway",0.7861,-1,0.6695,-1,-0.197,0.672]
[4,21,"202206_AT","ARL4C","ADP-ribosylation factor-like 4C","---","---","small GTPase mediated signal transduction","nucleotide binding /// GTPase activity /// GTP binding","intracellular /// nucleus","signal transduction,signaling pathway",1.0906,-1,1.2176,-3,-0.0071,0.9879]
[4,22,"202887_S_AT","DDIT4","DNA-damage-inducible transcript 4","---","---","---","---","---","unknown",3.3989,1,0,-2,-0.2085,0.6537]
[4,23,"202718_AT","IGFBP2","insulin-like growth factor binding protein 2, 36kDa","Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","regulation of cell growth","insulin-like growth factor binding /// growth factor binding","extracellular region /// extracellular space","cell growth,differentiation",1.5237,-1,0,-3,0.0233,0.9604]
[4,24,"212218_S_AT","FASN","fatty acid synthase","Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","fatty acid metabolic process /// fatty acid biosynthetic process /// metabolic process /// lipid biosynthetic process /// biosynthetic process","catalytic activity /// fatty-acid synthase activity /// [acyl-carrier-protein] S-acetyltransferase activity /// [acyl-carrier-protein] S-malonyltransferase activity /// 3-oxoacyl-[acyl-carrier-protein] synthase activity /// 3-oxoacyl-[acyl-carrier-protein] reductase activity /// 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity /// enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity /// oleoyl-[acyl-carrier-protein] hydrolase activity /// protein binding /// acyl-ACP thioesterase activity /// oxidoreductase activity /// transferase activity /// hydrolase activity /// hydrolase activity, acting on ester bonds /// lyase activity /// phosphopantetheine binding /// cofactor binding","cytoplasm /// glycogen granule","biosynthesis,metabolism,metabolic process,biosynthetic process",3.3316,1,0,-1,0.4701,0.2871]
[4,25,"201625_S_AT","INSIG1","insulin induced gene 1","---","---","lipid metabolic process /// metabolic process /// steroid metabolic process /// cholesterol metabolic process /// cell proliferation","---","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",1.9159,-1,0,-3,0.2453,0.596]
[4,26,"200832_S_AT","SCD","stearoyl-CoA desaturase (delta-9-desaturase)","Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","lipid metabolic process /// fatty acid biosynthetic process /// lipid biosynthetic process","stearoyl-CoA 9-desaturase activity /// stearoyl-CoA 9-desaturase activity /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",1.8984,1,0,-3,0.2984,0.5156]
[4,27,"201195_S_AT","SLC7A5","solute carrier family 7 (cationic amino acid transporter, y+ system), member 5","---","---","amino acid metabolic process /// transport /// transport /// amino acid transport /// neutral amino acid transport","amino acid transmembrane transporter activity /// amino acid transmembrane transporter activity /// neutral amino acid transmembrane transporter activity /// peptide antigen binding","plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",5.7801,1,0,-1,0.352,0.4388]
[4,28,"202644_S_AT","TNFAIP3","tumor necrosis factor, alpha-induced protein 3","---","---","ubiquitin cycle /// apoptosis /// anti-apoptosis /// negative regulation of I-kappaB kinase/NF-kappaB cascade","DNA binding /// protein binding /// peptidase activity /// cysteine-type peptidase activity /// zinc ion binding /// hydrolase activity /// metal ion binding","nucleus /// cytoplasm","apoptosis",7.263,1,0,-3,0.4089,0.3624]
[4,29,"201502_S_AT","NFKBIA","nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","protein import into nucleus, translocation /// apoptosis /// cytoplasmic sequestering of NF-kappaB /// regulation of cell proliferation /// regulation of NF-kappaB import into nucleus /// cytoplasmic sequestering of transcription factor /// cytoplasmic sequestering of transcription factor /// negative regulation of DNA binding /// negative regulation of myeloid cell differentiation /// negative regulation of Notch signaling pathway","protein binding /// protein binding /// transcription factor binding /// nuclear localization sequence binding /// ubiquitin protein ligase binding /// NF-kappaB binding","nucleus /// cytoplasm /// cytoplasm /// cytosol","dna repair,transcription:cell growth,differentiation:apoptosis:cell cycle,proliferation:signal transduction,signaling pathway",7.1201,1,0,0,0.394,0.3818]
[4,30,"216620_S_AT","ARHGEF10","Rho guanine nucleotide exchange factor (GEF) 10","---","---","regulation of Rho protein signal transduction","guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity","intracellular","signal transduction,signaling pathway",1.1367,-1,1.5665,-1,0.3526,0.438]
[]
[null,null,5]
[5,1,"213518_AT","PRKCI","protein kinase C, iota","G_Protein_Signaling /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","protein amino acid phosphorylation /// protein amino acid phosphorylation /// protein targeting to membrane /// cytoskeleton organization and biogenesis /// actin filament organization /// signal transduction /// intracellular signaling cascade /// membrane organization and biogenesis /// vesicle-mediated transport /// establishment of apical/basal cell polarity /// eye photoreceptor cell development /// establishment and/or maintenance of epithelial cell polarity /// intercellular junction assembly and maintenance /// secretion","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// atypical protein kinase C activity /// atypical protein kinase C activity /// atypical protein kinase C activity /// protein binding /// ATP binding /// ATP binding /// phospholipid binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding","polarisome /// nucleus /// cytoplasm /// endosome /// cytosol /// apical part of cell","transport,ion channel:nuclear matrix,cytoskeleton:signal transduction,signaling pathway",10.3402,1,0,-2,-0.7278,0.0637]
[5,2,"202912_AT","ADM","adrenomedullin","Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","cAMP biosynthetic process /// progesterone biosynthetic process /// signal transduction /// cell-cell signaling /// heart development /// female pregnancy /// excretion /// circulation /// positive regulation of cell proliferation /// response to wounding","receptor binding /// hormone activity","extracellular region /// extracellular space /// soluble fraction","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",16.7275,1,1.4605,-2,-0.1531,0.7431]
[5,3,"204799_AT","ZBED4","zinc finger, BED-type containing 4","---","---","---","DNA binding /// zinc ion binding /// metal ion binding /// protein dimerization activity","---","unknown",7.7061,1,0,-2,-0.2458,0.5951]
[5,4,"200821_AT","LAMP2","lysosomal-associated membrane protein 2","---","---","glycogen metabolic process","---","membrane fraction /// lysosome /// lysosome /// lysosomal membrane /// endosome /// late endosome /// membrane /// integral to membrane /// platelet dense granule membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",5.8323,1,1.4911,-4,-0.2409,0.6028]
[5,5,"219581_AT","TSEN2","tRNA splicing endonuclease 2 homolog (S. cerevisiae)","---","---","tRNA splicing /// mRNA processing /// tRNA processing","tRNA-intron endonuclease activity /// DNA binding /// nuclease activity /// endonuclease activity /// hydrolase activity","tRNA-intron endonuclease complex",null,7.0411,1,0,-4,0.0356,0.9396]
[5,6,"208933_S_AT","LGALS8","lectin, galactoside-binding, soluble, 8 (galectin 8)","---","---","---","sugar binding /// sugar binding","extracellular space /// cytoplasm","unknown",11.7917,1,1.2654,-4,-0.617,0.1399]
[5,7,"210802_S_AT","DIMT1L","DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)","---","---","rRNA modification /// rRNA processing","rRNA (adenine-N6,N6-)-dimethyltransferase activity /// RNA binding /// methyltransferase activity /// rRNA methyltransferase activity /// rRNA (adenine) methyltransferase activity /// transferase activity","---",null,5.6492,1,0,-2,0.121,0.7961]
[5,8,"213754_S_AT","PAIP1","poly(A) binding protein interacting protein 1","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translational initiation /// regulation of translation /// RNA metabolic process /// mRNA stabilization","RNA binding /// protein binding /// protein binding /// translation activator activity","cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",8.7424,1,0,-4,-0.5264,0.2248]
[5,9,"206686_AT","PDK1","pyruvate dehydrogenase kinase, isozyme 1","Krebs-TCA_Cycle","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Krebs-TCA_Cycle/Hs_Krebs-TCA_Cycle.htm","carbohydrate metabolic process /// glucose metabolic process /// glucose metabolic process /// small GTPase mediated signal transduction /// peptidyl-histidine phosphorylation","protein kinase activity /// protein histidine kinase activity /// [pyruvate dehydrogenase (lipoamide)] kinase activity /// ATP binding /// kinase activity /// transferase activity","mitochondrion /// mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway",7.6617,1,0,-2,0.2098,0.6516]
[5,10,"221749_AT","YTHDF3","YTH domain family, member 3","---","---","---","---","cytoplasm","unknown",10.7213,1,1.3472,-4,-0.6772,0.0947]
[5,11,"219324_AT","NOL12 /// TRIOBP","TRIO and F-actin binding protein /// nucleolar protein 12","---","---","sensory perception of sound /// actin modification /// barbed-end actin filament capping","RNA binding /// actin binding /// GTP-Rho binding /// rRNA binding /// myosin II binding","nucleolus /// cytoplasm /// cytoskeleton /// actin cytoskeleton",null,3.5644,1,0,-4,-0.0156,0.9735]
[5,12,"202158_S_AT","CUGBP2","CUG triplet repeat, RNA binding protein 2","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA processing","nucleotide binding /// nucleic acid binding /// RNA binding","cytoplasm",null,8.9141,1,1.4444,-4,-0.7731,0.0415]
[5,13,"212063_AT","CD44","CD44 molecule (Indian blood group)","---","---","cell adhesion /// cell-matrix adhesion /// cell-cell adhesion","receptor activity /// protein binding /// protein binding /// collagen binding /// hyaluronic acid binding /// hyaluronic acid binding","integral to plasma membrane /// membrane /// integral to membrane","cell adhesion",7.9325,1,0,-4,-0.2018,0.6644]
[5,14,"212019_AT","RSL1D1","ribosomal L1 domain containing 1","---","---","translation","structural constituent of ribosome /// protein binding","intracellular /// ribosome",null,6.2799,1,0,-4,-0.0722,0.8777]
[5,15,"203044_AT","CHSY1","carbohydrate (chondroitin) synthase 1","---","---","---","transferase activity /// metal ion binding /// glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity /// N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity","membrane /// integral to membrane","unknown",9.6925,1,0,-4,-0.7638,0.0457]
[5,16,"204824_AT","ENDOG","endonuclease G","---","---","DNA metabolic process","magnesium ion binding /// nucleic acid binding /// DNA binding /// nuclease activity /// endonuclease activity /// hydrolase activity /// manganese ion binding /// metal ion binding","mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",6.3471,1,0,-2,0.1209,0.7962]
[5,17,"219470_X_AT","CCNJ","cyclin J","---","---","regulation of progression through cell cycle","---","nucleus","cell cycle,proliferation",7.9584,1,0,-2,-0.3085,0.5009]
[5,18,"221428_S_AT","TBL1XR1","transducin (beta)-like 1X-linked receptor 1","---","---","transcription /// regulation of transcription, DNA-dependent /// ubiquitin cycle /// chromatin modification","---","---","dna repair,transcription",6.9717,1,1.2948,-1,-0.2381,0.6071]
[5,19,"204875_S_AT","GMDS","GDP-mannose 4,6-dehydratase","---","---","carbohydrate metabolic process /// leukocyte adhesion /// GDP-mannose metabolic process /// 'de novo' GDP-L-fucose biosynthetic process /// cellular metabolic process","catalytic activity /// GDP-mannose 4,6-dehydratase activity /// GDP-mannose 4,6-dehydratase activity /// lyase activity /// coenzyme binding","intracellular /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",9.189,1,1.285,-2,-0.0824,0.8607]
[5,20,"213188_S_AT","MINA","MYC induced nuclear antigen","---","---","---","---","---","unknown",9.0417,1,0,-4,-0.4468,0.3149]
[5,21,"218647_S_AT","YRDC","yrdC domain containing (E. coli)","---","---","negative regulation of transport","receptor activity","---","transport,ion channel",4.6242,1,1.3373,-4,0.1308,0.7798]
[5,22,"212641_AT","HIVEP2","human immunodeficiency virus type I enhancer binding protein 2","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription",4.9718,1,0,-4,0.0843,0.8575]
[5,23,"212847_AT","FUBP1","Far upstream element (FUSE) binding protein 1","---","---","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter","DNA binding /// single-stranded DNA binding /// transcription factor activity /// RNA binding /// protein binding","---","dna repair,transcription",10.1324,1,0,-2,-0.3899,0.3872]
[5,24,"212640_AT","PTPLB","protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b","---","---","---","protein binding","---","unknown",6.6045,1,1.417,-4,-0.191,0.6816]
[5,25,"204203_AT","CEBPG","CCAAT/enhancer binding protein (C/EBP), gamma","---","---","liver development /// transcription /// regulation of transcription, DNA-dependent /// immune response /// immune response /// B cell differentiation /// B cell differentiation /// natural killer cell mediated cytotoxicity /// natural killer cell mediated cytotoxicity /// enucleate erythrocyte differentiation /// enucleate erythrocyte differentiation /// positive regulation of DNA binding /// negative regulation of transcription factor activity /// negative regulation of transcription factor activity /// positive regulation of interferon-gamma biosynthetic process /// positive regulation of interferon-gamma biosynthetic process /// positive regulation of DNA repair /// positive regulation of DNA repair /// positive regulation of transcription factor activity","DNA binding /// DNA binding /// transcription factor activity /// protein binding /// transcription factor binding /// sequence-specific DNA binding /// sequence-specific DNA binding /// protein heterodimerization activity /// protein dimerization activity","nucleus /// nucleus","dna repair,transcription:cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:immune response",5.4411,1,0.0844,-2,0.1032,0.8257]
[5,26,"203387_S_AT","TBC1D4","TBC1 domain family, member 4","---","---","regulation of Rab GTPase activity","GTPase activator activity /// Rab GTPase activator activity","intracellular",null,9.7235,1,1.0591,-4,-0.7582,0.0482]
[5,27,"201848_S_AT","BNIP3","BCL2/adenovirus E1B 19kDa interacting protein 3","---","---","response to hypoxia /// DNA fragmentation during apoptosis /// chromatin remodeling /// oxygen and reactive oxygen species metabolic process /// apoptosis /// apoptosis /// anti-apoptosis /// induction of apoptosis /// cell death /// cell death /// negative regulation of survival gene product activity /// positive regulation of apoptosis /// negative regulation of membrane potential /// regulation of mitochondrial membrane permeability /// neuron apoptosis /// defense response to virus","protein binding /// identical protein binding /// protein homodimerization activity /// protein heterodimerization activity","nucleus /// nuclear envelope /// nucleoplasm /// cytoplasm /// mitochondrion /// mitochondrion /// mitochondrion /// mitochondrial envelope /// membrane /// integral to membrane /// dendrite /// integral to mitochondrial outer membrane /// mitochondrial membrane /// mitochondrial membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis",18.9282,1,0,-4,-0.5329,0.2181]
[5,28,"203584_AT","TTC35","tetratricopeptide repeat domain 35","---","---","---","binding","endoplasmic reticulum","unknown",9.8369,1,1.7889,-4,-0.4301,0.3355]
[5,29,"211423_S_AT","SC5DL","sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","lipid metabolic process /// steroid biosynthetic process /// metabolic process /// lipid biosynthetic process /// sterol biosynthetic process","C-5 sterol desaturase activity /// catalytic activity /// iron ion binding /// oxidoreductase activity","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",4.1992,1,0,-2,0.3001,0.5131]
[5,30,"209845_AT","MKRN1","makorin, ring finger protein, 1","---","---","---","nucleic acid binding /// protein binding /// protein binding /// zinc ion binding /// metal ion binding","---","unknown",11.4232,1,0,-4,-0.6281,0.1309]
[5,31,"218936_S_AT","CCDC59","coiled-coil domain containing 59","---","---","---","protein binding","---","unknown",6.1111,1,0,-2,-0.0786,0.867]
[5,32,"210111_S_AT","KIAA0265","KIAA0265 protein","---","---","---","---","---","unknown",11.0308,1,0,-2,-0.5109,0.2413]
[5,33,"220239_AT","KLHL7","kelch-like 7 (Drosophila)","---","---","---","protein binding","nucleolus","unknown",6.3925,1,0,-4,0.1815,0.697]
[5,34,"222200_S_AT","BSDC1","BSD domain containing 1","---","---","---","---","---","unknown",4.1644,1,0,-4,0.2107,0.6502]
[5,35,"213189_AT","MINA","MYC induced nuclear antigen","---","---","---","---","---","unknown",12.3439,1,0,-2,-0.4347,0.3298]
[5,36,"205282_AT","LRP8","low density lipoprotein receptor-related protein 8, apolipoprotein e receptor","---","---","proteolysis /// lipid metabolic process /// lipid metabolic process /// endocytosis /// endocytosis /// endocytosis /// signal transduction /// cytokine and chemokine mediated signaling pathway","receptor activity /// transmembrane receptor activity /// calcium ion binding /// lipoprotein binding /// apolipoprotein E receptor activity /// apolipoprotein E receptor activity /// apolipoprotein E receptor activity","plasma membrane /// membrane /// integral to membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway:proteolysis",4.089,1,0,-4,0.3091,0.4999]
[5,37,"213373_S_AT","CASP8","caspase 8, apoptosis-related cysteine peptidase","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","proteolysis /// proteolysis /// proteolysis /// apoptosis /// apoptotic program /// regulation of apoptosis /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// protein binding /// protein binding /// peptidase activity /// cysteine-type peptidase activity /// cysteine-type peptidase activity /// hydrolase activity /// caspase activity /// caspase activity /// identical protein binding","cytoplasm /// mitochondrion /// cytoskeleton","apoptosis:proteolysis",11.7774,1,0,-2,-0.5104,0.2418]
[5,38,"205135_S_AT","NUFIP1","nuclear fragile X mental retardation protein interacting protein 1","---","---","RNA processing /// positive regulation of transcription from RNA polymerase II promoter","nucleic acid binding /// DNA binding /// RNA binding /// RNA binding /// protein binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus /// perichromatin fibrils /// nucleolus /// cytosolic ribosome (sensu Eukaryota) /// transcription elongation factor complex /// nuclear matrix /// presynaptic active zone","dna repair,transcription",6.4038,1,0,-4,-0.0001,0.9998]
[5,39,"202067_S_AT","LDLR","low density lipoprotein receptor (familial hypercholesterolemia)","Statin_Pathway_PharmGKB /// Statin_Pathway_PharmGKB /// Wnt_signaling /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","protein amino acid O-linked glycosylation /// lipid metabolic process /// lipid metabolic process /// transport /// lipid transport /// endocytosis /// endocytosis /// steroid metabolic process /// cholesterol metabolic process /// cholesterol absorption /// cholesterol transport /// lipoprotein metabolic process /// cholesterol homeostasis","receptor activity /// transmembrane receptor activity /// low-density lipoprotein receptor activity /// low-density lipoprotein receptor activity /// lipid transporter activity /// calcium ion binding /// protein binding /// protein binding /// lipoprotein binding","endosome /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",4.3379,1,0,-2,0.4691,0.2883]
[5,40,"203093_S_AT","TIMM44","translocase of inner mitochondrial membrane 44 homolog (yeast)","---","---","protein targeting /// protein targeting to mitochondrion /// transport /// intracellular protein transport /// protein transport","nucleotide binding /// receptor activity /// protein binding /// ATP binding /// protein transmembrane transporter activity","mitochondrion /// mitochondrial inner membrane /// mitochondrial inner membrane presequence translocase complex /// mitochondrial matrix /// membrane","transport,ion channel",5.617,1,0,-2,0.2668,0.563]
[5,41,"204243_AT","RLF","rearranged L-myc fusion","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// transcription factor activity /// protein binding /// zinc ion binding /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription",13.911,1,0,-2,-0.3995,0.3746]
[5,42,"218670_AT","PUS1","pseudouridylate synthase 1","---","---","tRNA processing /// tRNA processing","pseudouridylate synthase activity /// pseudouridylate synthase activity /// tRNA-pseudouridine synthase activity /// isomerase activity","nucleus",null,7.4221,1,0,-2,0.0174,0.9705]
[5,43,"202147_S_AT","IFRD1","interferon-related developmental regulator 1","Hypertrophy_model","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm","multicellular organismal development /// myoblast cell fate determination /// adult somatic muscle development /// cell differentiation /// muscle cell differentiation","---","nucleus","cell growth,differentiation",5.5731,1,0,-4,-0.1112,0.8124]
[5,44,"221652_S_AT","C12orf11","chromosome 12 open reading frame 11","---","---","---","---","---","unknown",11.1118,1,1.2501,-2,-0.6024,0.1523]
[5,45,"219326_S_AT","B3GNT2","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2","---","---","protein amino acid glycosylation","galactosyltransferase activity /// UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups /// manganese ion binding","membrane /// integral to membrane /// integral to membrane",null,6.6031,1,0,-2,-0.1018,0.8281]
[5,46,"202364_AT","MXI1","MAX interactor 1","---","---","transcription /// regulation of transcription, DNA-dependent /// negative regulation of cell proliferation /// cytoplasmic sequestering of transcription factor /// regulation of transcription","DNA binding /// DNA binding /// transcription corepressor activity /// transcription regulator activity","nucleus /// nucleus","dna repair,transcription:cell cycle,proliferation",6.247,1,0,-2,0.1656,0.7226]
[5,47,"201878_AT","ARIH1","ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)","---","---","ubiquitin-dependent protein catabolic process /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle","protein binding /// protein binding /// zinc ion binding /// small conjugating protein ligase activity /// metal ion binding","ubiquitin ligase complex /// cytoplasm",null,4.8619,1,1.4682,-4,0.2582,0.5762]
[5,48,"217823_S_AT","UBE2J1","ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)","---","---","protein modification process /// ubiquitin cycle","ubiquitin-protein ligase activity /// ligase activity /// small conjugating protein ligase activity","endoplasmic reticulum /// membrane /// integral to membrane",null,14.8539,-1,1.3908,-4,-0.5902,0.1631]
[5,49,"217739_S_AT","PBEF1","pre-B-cell colony enhancing factor 1","---","---","signal transduction /// cell-cell signaling /// positive regulation of cell proliferation /// pyridine nucleotide biosynthetic process","nicotinate phosphoribosyltransferase activity /// cytokine activity /// transferase activity /// transferase activity, transferring glycosyl groups /// nicotinamide phosphoribosyltransferase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",8.1585,1,1.2898,-4,-0.0956,0.8385]
[5,50,"201329_S_AT","ETS2","v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)","Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","skeletal development /// regulation of transcription, DNA-dependent","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// sequence-specific DNA binding","nucleus /// nucleus","dna repair,transcription",5.0995,-1,0.178,-4,0.3903,0.3866]
[5,51,"201849_AT","BNIP3","BCL2/adenovirus E1B 19kDa interacting protein 3","---","---","response to hypoxia /// DNA fragmentation during apoptosis /// chromatin remodeling /// oxygen and reactive oxygen species metabolic process /// apoptosis /// apoptosis /// anti-apoptosis /// induction of apoptosis /// cell death /// cell death /// negative regulation of survival gene product activity /// positive regulation of apoptosis /// negative regulation of membrane potential /// regulation of mitochondrial membrane permeability /// neuron apoptosis /// defense response to virus","protein binding /// identical protein binding /// protein homodimerization activity /// protein heterodimerization activity","nucleus /// nuclear envelope /// nucleoplasm /// cytoplasm /// mitochondrion /// mitochondrion /// mitochondrion /// mitochondrial envelope /// membrane /// integral to membrane /// dendrite /// integral to mitochondrial outer membrane /// mitochondrial membrane /// mitochondrial membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis",23.2531,1,0,-2,-0.3311,0.4682]
[5,52,"36553_AT","ASMTL","acetylserotonin O-methyltransferase-like","---","---","melatonin biosynthetic process","methyltransferase activity /// O-methyltransferase activity /// transferase activity /// acetylserotonin O-methyltransferase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",9.6863,1,0,-4,-0.0211,0.9641]
[5,53,"206039_AT","RAB33A","RAB33A, member RAS oncogene family","---","---","small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTPase activity /// GTP binding","membrane","transport,ion channel:signal transduction,signaling pathway",16.4859,1,0,-2,-0.2013,0.6652]
[5,54,"202314_AT","CYP51A1","cytochrome P450, family 51, subfamily A, polypeptide 1","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","electron transport /// steroid biosynthetic process /// cholesterol biosynthetic process /// lipid biosynthetic process /// sterol biosynthetic process","monooxygenase activity /// iron ion binding /// protein binding /// sterol 14-demethylase activity /// oxidoreductase activity /// heme binding /// metal ion binding","endoplasmic reticulum /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",12.7309,1,0,-4,0.0945,0.8403]
[5,55,"205251_AT","PER2","period homolog 2 (Drosophila)","Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","transcription /// regulation of transcription, DNA-dependent /// signal transduction /// circadian rhythm /// rhythmic process","signal transducer activity /// protein binding","cytoplasm","dna repair,transcription:signal transduction,signaling pathway",9.7892,1,0.3833,-2,-0.0716,0.8787]
[5,56,"210512_S_AT","VEGFA","vascular endothelial growth factor A","Hypertrophy_model /// Hypertrophy_model","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm","regulation of progression through cell cycle /// angiogenesis /// angiogenesis /// angiogenesis /// vasculogenesis /// response to hypoxia /// signal transduction /// multicellular organismal development /// nervous system development /// cell proliferation /// positive regulation of cell proliferation /// cell migration /// cell differentiation /// positive regulation of vascular endothelial growth factor receptor signaling pathway /// negative regulation of apoptosis /// induction of positive chemotaxis","vascular endothelial growth factor receptor binding /// protein binding /// growth factor activity /// growth factor activity /// heparin binding /// heparin binding /// protein homodimerization activity /// extracellular matrix binding","proteinaceous extracellular matrix /// extracellular space /// extracellular space /// membrane","cell growth,differentiation:apoptosis:cell cycle,proliferation:signal transduction,signaling pathway",23.4239,1,0,-2,0.1132,0.8091]
[]
[null,null,6]
[6,1,"219361_S_AT","ISG20L1","interferon stimulated exonuclease gene 20kDa-like 1","---","---","---","exonuclease activity","intracellular","unknown",1.2623,1,0,-2,0.8321,0.0202]
[6,2,"218611_AT","IER5","immediate early response 5","---","---","---","---","---","unknown",2.0564,-1,1.5354,-4,0.5312,0.2198]
[6,3,"201834_AT","PRKAB1","protein kinase, AMP-activated, beta 1 non-catalytic subunit","Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","carbohydrate metabolic process /// fatty acid biosynthetic process /// signal transduction /// lipid biosynthetic process","hydrolase activity, hydrolyzing O-glycosyl compounds /// protein binding","nucleus","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway",1.1574,1,0,-2,0.8187,0.0243]
[6,4,"213293_S_AT","TRIM22","tripartite motif-containing 22","---","---","regulation of transcription, DNA-dependent /// immune response /// response to virus","transcription factor activity /// transcription corepressor activity /// protein binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription:immune response",1.6431,1,0,0,0.5683,0.1831]
[6,5,"209375_AT","XPC","xeroderma pigmentosum, complementation group C","---","---","DNA repair /// DNA repair /// nucleotide-excision repair /// nucleotide-excision repair /// response to DNA damage stimulus","DNA binding /// damaged DNA binding /// damaged DNA binding /// single-stranded DNA binding /// protein binding","nucleus","dna repair,transcription",1.1468,1,0.0059,4,0.6337,0.1265]
[6,6,"203725_AT","GADD45A","growth arrest and DNA-damage-inducible, alpha","Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// DNA repair /// apoptosis /// response to DNA damage stimulus /// cell cycle /// cell cycle arrest /// cell cycle arrest","---","nucleus /// nucleus","dna repair,transcription:apoptosis:cell cycle,proliferation",2.6107,1,0,0,0.761,0.0469]
[6,7,"202284_S_AT","CDKN1A","cyclin-dependent kinase inhibitor 1A (p21, Cip1)","Cell_cycle_KEGG /// Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// response to DNA damage stimulus /// cell cycle /// cell cycle arrest /// cell cycle arrest /// negative regulation of cell proliferation /// negative regulation of cell proliferation /// induction of apoptosis by intracellular signals /// response to UV /// positive regulation of B cell proliferation /// negative regulation of apoptosis /// positive regulation of non-apoptotic programmed cell death /// negative regulation of cyclin-dependent protein kinase activity","protein kinase activity /// protein kinase inhibitor activity /// cyclin-dependent protein kinase inhibitor activity /// cyclin-dependent protein kinase inhibitor activity /// protein binding /// protein binding /// zinc ion binding /// kinase activity /// cyclin binding /// metal ion binding","cyclin-dependent protein kinase holoenzyme complex /// nucleus /// nucleus /// cytoplasm /// cytosol","apoptosis:cell cycle,proliferation",2.192,1,0.0009,2,0.8018,0.0301]
[6,8,"202672_S_AT","ATF3","activating transcription factor 3","Hypertrophy_model /// Hypertrophy_model /// Hypertrophy_model /// Hypertrophy_model /// Hypertrophy_model /// Smooth_muscle_contraction /// Smooth_muscle_contraction /// Smooth_muscle_contraction /// Smooth_muscle_contraction /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// transcription corepressor activity /// protein binding /// sequence-specific DNA binding /// protein dimerization activity","nucleus","dna repair,transcription",5.7929,1,0,-2,0.7533,0.0506]
[6,9,"201631_S_AT","IER3","immediate early response 3","---","---","apoptosis /// anti-apoptosis /// anti-apoptosis /// anatomical structure morphogenesis","---","membrane /// integral to membrane","apoptosis",8.365,1,0,-2,0.8107,0.027]
[]
[null,null,7]
[7,1,"218251_AT","MID1IP1","MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))","---","---","negative regulation of microtubule depolymerization /// negative regulation of microtubule depolymerization","protein binding /// protein binding","cytoplasm /// microtubule /// microtubule cytoskeleton /// microtubule cytoskeleton",null,2.3678,-1,1.303,-2,0.1475,0.7522]
[7,2,"219217_AT","NARS2","asparaginyl-tRNA synthetase 2, mitochondrial (putative)","---","---","translation /// tRNA aminoacylation for protein translation /// asparaginyl-tRNA aminoacylation /// aspartyl-tRNA aminoacylation","nucleotide binding /// nucleic acid binding /// aminoacyl-tRNA ligase activity /// aspartate-tRNA ligase activity /// asparagine-tRNA ligase activity /// ATP binding /// ligase activity","cytoplasm /// mitochondrion",null,7.1874,-1,0,0,0.2216,0.6329]
[7,3,"212181_S_AT","NUDT4","nudix (nucleoside diphosphate linked moiety X)-type motif 4","---","---","intracellular signaling cascade /// cyclic nucleotide metabolic process /// calcium-mediated signaling /// cyclic-nucleotide-mediated signaling /// regulation of RNA export from nucleus /// intracellular transport","magnesium ion binding /// diphosphoinositol-polyphosphate diphosphatase activity /// diphosphoinositol-polyphosphate diphosphatase activity /// diphosphoinositol-polyphosphate diphosphatase activity /// hydrolase activity /// manganese ion binding /// metal ion binding","intracellular /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",9.0072,-1,0,-2,-0.4519,0.3087]
[7,4,"211733_X_AT","SCP2","sterol carrier protein 2","Mitochondrial_fatty_acid_betaoxidation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Mitochondrial_fatty_acid_betaoxidation/Hs_Mitochondrial_fatty_acid_betaoxidation.htm","steroid biosynthetic process /// transport /// lipid transport /// metabolic process","sterol carrier activity /// sterol carrier activity /// protein binding /// lipid binding /// oxidoreductase activity /// transferase activity","cytoplasm /// mitochondrion /// peroxisome /// peroxisome","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",11.0359,-1,0,-4,-0.6532,0.1116]
[7,5,"212193_S_AT","LARP1","La ribonucleoprotein domain family, member 1","---","---","---","RNA binding /// protein binding","---","unknown",6.44,-1,0,2,0.091,0.8461]
[7,6,"204279_AT","PSMB9","proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)","Proteasome_Degradation /// Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","carbohydrate metabolic process /// glycogen metabolic process /// proteolysis /// ubiquitin-dependent protein catabolic process /// immune response /// regulation of signal transduction /// antigen processing and presentation /// regulation of phosphoprotein phosphatase activity","endopeptidase activity /// threonine endopeptidase activity /// protein phosphatase inhibitor activity /// peptidase activity /// hydrolase activity","proteasome complex (sensu Eukaryota) /// cytoplasm /// cytosol /// proteasome core complex (sensu Eukaryota) /// protein complex","biosynthesis,metabolism,metabolic process,biosynthetic process:immune response:signal transduction,signaling pathway:proteolysis",2.4898,-1,0,-2,-0.8121,0.0265]
[7,7,"218135_AT","ERGIC2","ERGIC and golgi 2","---","---","transport /// ER to Golgi vesicle-mediated transport /// ER to Golgi vesicle-mediated transport","protein binding","endoplasmic reticulum /// ER-Golgi intermediate compartment /// membrane /// integral to membrane","transport,ion channel",5.5269,-1,0,0,-0.1315,0.7787]
[7,8,"218381_S_AT","U2AF2","U2 small nuclear RNA auxiliary factor 2","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","nuclear mRNA splicing, via spliceosome /// mRNA processing /// mRNA processing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// protein binding","nucleus /// spliceosome /// spliceosome",null,8.542,-1,0,-2,0.0772,0.8693]
[7,9,"204009_S_AT","KRAS","v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog","G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// MAPK_Cascade","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_MAPK_Cascade/Hs_MAPK_Cascade.htm","regulation of progression through cell cycle /// small GTPase mediated signal transduction /// sensory perception of sound","nucleotide binding /// GTPase activity /// protein binding /// GTP binding","intracellular /// membrane","cell cycle,proliferation:signal transduction,signaling pathway",2.3263,-1,0,0,-0.878,0.0093]
[7,10,"209694_AT","PTS","6-pyruvoyltetrahydropterin synthase","---","---","amino acid metabolic process /// L-phenylalanine catabolic process /// tetrahydrobiopterin biosynthetic process /// tetrahydrobiopterin biosynthetic process /// central nervous system development","6-pyruvoyltetrahydropterin synthase activity /// 6-pyruvoyltetrahydropterin synthase activity /// protein binding /// zinc ion binding /// lyase activity /// identical protein binding /// metal ion binding","cytoplasm /// mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",6.861,-1,0,0,0.2004,0.6667]
[7,11,"202333_S_AT","UBE2B","ubiquitin-conjugating enzyme E2B (RAD6 homolog)","---","---","DNA repair /// postreplication repair /// protein modification process /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle /// response to DNA damage stimulus /// sperm axoneme assembly","ubiquitin-protein ligase activity /// protein binding /// ligase activity /// small conjugating protein ligase activity","chromatin /// membrane","dna repair,transcription",11.8655,-1,0,-2,0.1231,0.7926]
[7,12,"203931_S_AT","MRPL12","mitochondrial ribosomal protein L12","---","---","translation /// translation","RNA binding /// structural constituent of ribosome /// structural constituent of ribosome","intracellular /// mitochondrion /// mitochondrial large ribosomal subunit /// ribosome /// ribonucleoprotein complex",null,10.5509,1,0,-4,0.0958,0.8381]
[7,13,"203279_AT","EDEM1","ER degradation enhancer, mannosidase alpha-like 1","---","---","response to unfolded protein /// ER-associated protein catabolic process /// ER-associated protein catabolic process","mannosyl-oligosaccharide 1,2-alpha-mannosidase activity /// calcium ion binding /// protein binding","endoplasmic reticulum /// membrane /// integral to membrane /// integral to endoplasmic reticulum membrane /// integral to endoplasmic reticulum membrane",null,4.4658,-1,0.0004,-2,-0.4281,0.3379]
[7,14,"202602_S_AT","HTATSF1","HIV-1 Tat specific factor 1","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// viral genome replication","nucleotide binding /// nucleic acid binding /// RNA polymerase II transcription factor activity /// transcription elongation regulator activity /// RNA binding /// protein binding","nucleus","dna repair,transcription",6.3585,-1,0,0,-0.6754,0.0959]
[7,15,"217933_S_AT","LAP3","leucine aminopeptidase 3","---","---","proteolysis /// proteolysis /// protein metabolic process","magnesium ion binding /// magnesium ion binding /// aminopeptidase activity /// leucyl aminopeptidase activity /// leucyl aminopeptidase activity /// peptidase activity /// zinc ion binding /// zinc ion binding /// hydrolase activity /// prolyl aminopeptidase activity /// prolyl aminopeptidase activity /// manganese ion binding /// manganese ion binding /// metal ion binding","intracellular /// cytoplasm /// cytoplasm /// mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process:proteolysis",12.3471,-1,0.4029,-2,-0.174,0.7091]
[7,16,"201807_AT","VPS26A","vacuolar protein sorting 26 homolog A (S. pombe)","---","---","transport /// vacuolar transport /// protein transport /// retrograde transport, endosome to Golgi /// retrograde transport, endosome to Golgi","protein binding /// protein transporter activity","cytoplasm /// endosome /// cytosol /// membrane /// retromer complex","transport,ion channel",19.398,-1,0,2,-0.7075,0.0753]
[7,17,"212174_AT","AK2","adenylate kinase 2","---","---","nucleobase, nucleoside, nucleotide and nucleic acid metabolic process","nucleotide binding /// adenylate kinase activity /// adenylate kinase activity /// ATP binding /// kinase activity /// transferase activity /// phosphotransferase activity, phosphate group as acceptor /// nucleotide kinase activity /// nucleoside kinase activity","mitochondrion /// mitochondrial inner membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",4.5186,-1,0,-2,0.0696,0.8822]
[7,18,"200659_S_AT","PHB","prohibitin","---","---","regulation of progression through cell cycle /// DNA replication /// signal transduction /// negative regulation of cell proliferation /// negative regulation of transcription /// histone deacetylation /// regulation of apoptosis /// regulation of transcription","protein binding /// transcription activator activity /// transcription repressor activity","nucleus /// nucleoplasm /// mitochondrion /// mitochondrion /// mitochondrial inner membrane /// integral to plasma membrane /// membrane","dna repair,transcription:apoptosis:cell cycle,proliferation:dna replication:signal transduction,signaling pathway",10.1538,-1,0,-2,0.1558,0.7387]
[7,19,"220865_S_AT","PDSS1","prenyl (decaprenyl) diphosphate synthase, subunit 1","---","---","ubiquinone biosynthetic process /// ubiquinone biosynthetic process /// isoprenoid biosynthetic process /// isoprenoid biosynthetic process","trans-hexaprenyltranstransferase activity /// transferase activity /// protein heterodimerization activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",7.3951,-1,1.6193,2,-0.3592,0.4287]
[7,20,"219110_AT","NOLA1","nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)","---","---","rRNA processing /// ribosome biogenesis and assembly","RNA binding /// cation channel activity /// rRNA binding","membrane fraction /// small nucleolar ribonucleoprotein complex /// ribonucleoprotein complex",null,6.516,-1,0.6768,-4,-0.2377,0.6077]
[7,21,"212885_AT","MPHOSPH10","M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)","---","---","rRNA processing /// RNA processing /// RNA splicing /// ribosome biogenesis and assembly","protein binding /// RNA splicing factor activity, transesterification mechanism","nucleus /// nucleolus /// small nucleolar ribonucleoprotein complex /// ribonucleoprotein complex",null,1.602,-1,1.3927,2,0.1388,0.7666]
[7,22,"211949_S_AT","NOLC1","nucleolar and coiled-body phosphoprotein 1","---","---","rRNA processing /// cell cycle /// mitosis","nucleotide binding /// protein binding /// ATP binding /// GTP binding","nucleolus /// cytoplasm /// cytoplasm","cell cycle,proliferation",6.7501,1,0,-2,0.5427,0.2081]
[7,23,"217971_AT","MAP2K1IP1","mitogen-activated protein kinase kinase 1 interacting protein 1","---","---","---","protein binding /// kinase activity","endosome /// membrane","unknown",7.5004,-1,0,-2,-0.5143,0.2376]
[7,24,"203828_S_AT","IL32","interleukin 32","---","---","defense response /// immune response /// cell adhesion","cytokine activity","extracellular space /// extracellular space","cell adhesion:immune response",6.6939,-1,0,-2,0.0738,0.8751]
[7,25,"211339_S_AT","ITK","IL2-inducible T-cell kinase","---","---","protein amino acid phosphorylation /// cellular defense response /// signal transduction /// intracellular signaling cascade","nucleotide binding /// protein kinase activity /// protein-tyrosine kinase activity /// non-membrane spanning protein tyrosine kinase activity /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// metal ion binding","membrane","signal transduction,signaling pathway",1.8329,-1,1.5593,0,-0.5197,0.2319]
[7,26,"205324_S_AT","FTSJ1","FtsJ homolog 1 (E. coli)","---","---","rRNA processing","methyltransferase activity /// transferase activity","---",null,7.0312,-1,1.3183,-4,0.051,0.9136]
[7,27,"219956_AT","GALNT6","UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)","---","---","protein amino acid O-linked glycosylation","polypeptide N-acetylgalactosaminyltransferase activity /// polypeptide N-acetylgalactosaminyltransferase activity /// calcium ion binding /// sugar binding /// transferase activity /// transferase activity, transferring glycosyl groups /// manganese ion binding","membrane /// integral to membrane",null,15.36,-1,0,-2,0.1819,0.6963]
[7,28,"208877_AT","PAK2","p21 (CDKN1A)-activated kinase 2","Integrin-mediated_cell_adhesion_KEGG /// Integrin-mediated_cell_adhesion_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm","protein amino acid phosphorylation /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// negative regulation of protein kinase activity /// signal transduction /// protein amino acid autophosphorylation","nucleotide binding /// catalytic activity /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// identical protein binding","---","signal transduction,signaling pathway",5.2996,-1,1.7302,0,-0.316,0.4899]
[7,29,"212432_AT","GRPEL1","GrpE-like 1, mitochondrial (E. coli)","---","---","protein folding /// protein import into mitochondrial matrix","adenyl-nucleotide exchange factor activity /// protein binding /// protein homodimerization activity /// unfolded protein binding /// chaperone binding","mitochondrion /// mitochondrial matrix",null,0.5616,-1,1.7589,-2,0.1965,0.6728]
[7,30,"211961_S_AT","RAB7A","RAB7A, member RAS oncogene family","---","---","transport /// endocytosis /// small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTPase activity /// protein binding /// GTP binding","lysosome /// lysosome /// endosome /// late endosome /// late endosome /// cytoplasmic vesicle","transport,ion channel:signal transduction,signaling pathway",3.6833,-1,0.5818,-2,-0.3706,0.4131]
[7,31,"210337_S_AT","ACLY","ATP citrate lyase","Fatty_Acid_Synthesis /// Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","citrate metabolic process /// ATP catabolic process /// metabolic process /// lipid biosynthetic process /// coenzyme A metabolic process","nucleotide binding /// magnesium ion binding /// catalytic activity /// ATP citrate synthase activity /// ATP citrate synthase activity /// protein binding /// ATP binding /// transferase activity /// metal ion binding","cytoplasm /// citrate lyase complex","biosynthesis,metabolism,metabolic process,biosynthetic process",7.9964,1,0,-4,0.511,0.2411]
[7,32,"209860_S_AT","ANXA7","annexin A7","---","---","---","voltage-gated calcium channel activity /// calcium ion binding /// phospholipid binding /// calcium-dependent phospholipid binding","---","unknown",6.984,-1,1.9389,-4,0.0386,0.9345]
[7,33,"200749_AT","RAN","RAN, member RAS oncogene family","---","---","regulation of progression through cell cycle /// DNA metabolic process /// RNA export from nucleus /// protein export from nucleus /// transport /// intracellular protein transport /// nucleocytoplasmic transport /// mitotic spindle organization and biogenesis /// mitosis /// signal transduction /// signal transduction /// small GTPase mediated signal transduction /// protein transport /// androgen receptor signaling pathway /// positive regulation of transcription, DNA-dependent","nucleotide binding /// chromatin binding /// transcription coactivator activity /// GTPase activity /// GTPase activity /// protein binding /// protein binding /// GTP binding /// GTP binding /// androgen receptor binding","chromatin /// nuclear pore /// cytoplasm /// cytoplasm","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:cell cycle,proliferation:signal transduction,signaling pathway",4.2938,-1,1.2549,2,-0.1911,0.6815]
[7,34,"201953_AT","CIB1","calcium and integrin binding 1 (calmyrin)","---","---","double-strand break repair /// apoptosis /// apoptosis /// response to DNA damage stimulus /// cell adhesion","calcium ion binding /// calcium ion binding /// calcium ion binding /// protein binding /// protein binding /// protein binding","nucleoplasm /// nucleoplasm /// cytoplasm /// endoplasmic reticulum /// endoplasmic reticulum /// membrane /// membrane","cell adhesion:apoptosis",3.6638,-1,0,0,-0.1189,0.7996]
[7,35,"209340_AT","UAP1","UDP-N-acteylglucosamine pyrophosphorylase 1","---","---","UDP-N-acetylglucosamine biosynthetic process /// metabolic process","UDP-N-acetylglucosamine diphosphorylase activity /// UDP-N-acetylglucosamine diphosphorylase activity /// transferase activity /// nucleotidyltransferase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",9.8266,-1,0,-2,-0.1268,0.7865]
[7,36,"207628_S_AT","WBSCR22","Williams Beuren syndrome chromosome region 22","---","---","metabolic process","methyltransferase activity /// methyltransferase activity /// transferase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",4.0363,-1,0,0,0.1793,0.7005]
[7,37,"202675_AT","SDHB","succinate dehydrogenase complex, subunit B, iron sulfur (Ip)","Electron_Transport_Chain /// Krebs-TCA_Cycle","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Electron_Transport_Chain/Hs_Electron_Transport_Chain.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Krebs-TCA_Cycle/Hs_Krebs-TCA_Cycle.htm","tricarboxylic acid cycle /// tricarboxylic acid cycle /// electron transport /// transport /// aerobic respiration","iron ion binding /// succinate dehydrogenase (ubiquinone) activity /// electron carrier activity /// oxidoreductase activity /// metal ion binding /// iron-sulfur cluster binding /// 2 iron, 2 sulfur cluster binding /// 3 iron, 4 sulfur cluster binding /// 4 iron, 4 sulfur cluster binding","mitochondrion /// mitochondrion /// mitochondrial inner membrane /// membrane","transport,ion channel",10.1458,-1,0,0,0.2714,0.556]
[7,38,"201129_AT","SFRS7","splicing factor, arginine/serine-rich 7, 35kDa","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA processing /// mRNA processing /// RNA splicing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// protein binding /// zinc ion binding /// metal ion binding","nucleus",null,8.2331,-1,0,0,-0.3943,0.3814]
[7,39,"212411_AT","IMP4","IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)","---","---","rRNA processing /// rRNA processing /// ribosome biogenesis and assembly","protein binding","nucleolus /// ribonucleoprotein complex",null,15.8849,1,0.0008,2,0.2827,0.5389]
[7,40,"217722_S_AT","NGRN","neugrin, neurite outgrowth associated","---","---","protein modification process /// multicellular organismal development /// nervous system development /// cell differentiation /// neuron differentiation","tubulin-tyrosine ligase activity","nucleus","cell growth,differentiation",6.1067,-1,0,2,0.0558,0.9054]
[7,41,"209433_S_AT","PPAT","phosphoribosyl pyrophosphate amidotransferase","---","---","purine nucleotide biosynthetic process /// purine nucleotide biosynthetic process /// glutamine metabolic process /// metabolic process /// purine base biosynthetic process /// nucleoside metabolic process","magnesium ion binding /// catalytic activity /// amidophosphoribosyltransferase activity /// amidophosphoribosyltransferase activity /// iron ion binding /// transferase activity /// transferase activity, transferring glycosyl groups /// metal ion binding /// iron-sulfur cluster binding /// 4 iron, 4 sulfur cluster binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process",6.1376,-1,0,0,-0.3512,0.4398]
[7,42,"216194_S_AT","TBCB","tubulin folding cofactor B","---","---","protein folding /// multicellular organismal development /// nervous system development /// cell differentiation","protein binding","cytoplasm /// cytoskeleton /// microtubule /// microtubule cytoskeleton","cell growth,differentiation",10.328,1,0,0,-0.1509,0.7468]
[7,43,"212168_AT","RBM12","RNA binding motif protein 12","---","---","lipid metabolic process /// vesicle-mediated transport","nucleotide binding /// phosphatidylserine binding /// nucleic acid binding /// RNA binding /// transporter activity /// protein binding /// calcium-dependent phospholipid binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",10.5502,-1,0,-2,0.1051,0.8225]
[7,44,"201912_S_AT","GSPT1","G1 to S phase transition 1","---","---","G1/S transition of mitotic cell cycle /// mRNA catabolic process, nonsense-mediated decay /// translation","nucleotide binding /// translation release factor activity /// translation release factor activity /// GTPase activity /// GTPase activity /// protein binding /// protein binding /// GTP binding","intracellular","cell cycle,proliferation",5.0359,-1,0,-4,-0.4617,0.297]
[7,45,"205895_S_AT","NOLC1","nucleolar and coiled-body phosphoprotein 1","---","---","rRNA processing /// cell cycle /// mitosis","nucleotide binding /// protein binding /// ATP binding /// GTP binding","nucleolus /// cytoplasm /// cytoplasm","cell cycle,proliferation",10.7839,-1,0,0,0.5499,0.2009]
[7,46,"212773_S_AT","TOMM20","translocase of outer mitochondrial membrane 20 homolog (yeast)","---","---","protein targeting /// protein targeting to mitochondrion /// transport /// intracellular protein transport /// protein transport /// protein import into mitochondrion","protein binding /// protein transmembrane transporter activity /// protein transmembrane transporter activity /// unfolded protein binding","mitochondrion /// mitochondrial outer membrane translocase complex /// mitochondrial outer membrane translocase complex /// mitochondrial outer membrane translocase complex /// membrane /// integral to membrane /// outer membrane","transport,ion channel",9.648,-1,0.9563,2,-0.1311,0.7793]
[7,47,"201660_AT","ACSL3","Full-length cDNA clone CS0DF008YJ12 of Fetal brain of Homo sapiens (human) /// Acyl-CoA synthetase long-chain family member 3","Fatty_Acid_Degradation /// Fatty_Acid_Degradation /// Mitochondrial_fatty_acid_betaoxidation /// Mitochondrial_fatty_acid_betaoxidation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Degradation/Hs_Fatty_Acid_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Degradation/Hs_Fatty_Acid_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Mitochondrial_fatty_acid_betaoxidation/Hs_Mitochondrial_fatty_acid_betaoxidation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Mitochondrial_fatty_acid_betaoxidation/Hs_Mitochondrial_fatty_acid_betaoxidation.htm","lipid metabolic process /// fatty acid metabolic process /// metabolic process","magnesium ion binding /// catalytic activity /// fatty-acyl-CoA synthase activity /// long-chain-fatty-acid-CoA ligase activity /// protein binding /// ligase activity","mitochondrion /// peroxisome /// endoplasmic reticulum /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",5.6362,-1,0.6042,0,-0.6915,0.0853]
[7,48,"203119_AT","CCDC86","coiled-coil domain containing 86","---","---","---","---","---","unknown",10.1818,1,0,-2,0.2026,0.6631]
[7,49,"203622_S_AT","PNO1","partner of NOB1 homolog (S. cerevisiae)","---","---","---","RNA binding","nucleolus","unknown",2.8154,-1,1.7676,-2,0.1358,0.7715]
[7,50,"201563_AT","SORD","sorbitol dehydrogenase","---","---","sorbitol metabolic process /// visual perception","L-iditol 2-dehydrogenase activity /// zinc ion binding /// oxidoreductase activity /// metal ion binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process",5.0656,-1,0,0,-0.0296,0.9498]
[7,51,"212627_S_AT","EXOSC7","exosome component 7","---","---","rRNA processing /// rRNA processing /// RNA processing /// RNA catabolic process","3'-5'-exoribonuclease activity /// 3'-5'-exoribonuclease activity /// RNA binding /// RNA binding /// nuclease activity /// exonuclease activity /// protein binding /// hydrolase activity","exosome (RNase complex) /// exosome (RNase complex)",null,10.9926,-1,0,0,0.0922,0.8441]
[7,52,"213251_AT","SMARCA5","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5","---","---","nucleosome assembly /// chromatin remodeling /// chromatin remodeling /// transcription initiation /// regulation of transcription from RNA polymerase II promoter /// chromatin modification /// nucleosome positioning","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA binding /// RNA polymerase II transcription factor activity /// helicase activity /// helicase activity /// protein binding /// ATP binding /// ATP binding /// hydrolase activity /// ATPase activity /// histone binding","condensed chromosome /// nucleus /// nucleus /// nucleoplasm /// RSF complex","dna repair,transcription",8.2145,-1,0,-4,-0.4424,0.3202]
[7,53,"215438_X_AT","GSPT1","G1 to S phase transition 1","---","---","G1/S transition of mitotic cell cycle /// mRNA catabolic process, nonsense-mediated decay /// translation","nucleotide binding /// translation release factor activity /// translation release factor activity /// GTPase activity /// GTPase activity /// protein binding /// protein binding /// GTP binding","intracellular","cell cycle,proliferation",9.3585,-1,1.0894,2,-0.3217,0.4816]
[7,54,"203244_AT","PEX5","peroxisomal biogenesis factor 5","---","---","protein targeting to peroxisome /// transport /// protein transport","peroxisome targeting sequence binding /// receptor activity /// peroxisome matrix targeting signal-1 binding /// protein binding","cytoplasm /// peroxisome /// peroxisome /// peroxisomal membrane /// membrane","transport,ion channel",10.9728,-1,0,2,0.0283,0.952]
[7,55,"201223_S_AT","RAD23B","RAD23 homolog B (S. cerevisiae)","---","---","DNA repair /// nucleotide-excision repair /// nucleotide-excision repair /// protein modification process /// ubiquitin cycle /// response to DNA damage stimulus","single-stranded DNA binding /// protein binding","nucleus /// nucleus /// cytoplasm /// cytosol /// protein complex","dna repair,transcription",5.0086,-1,1.383,-2,-0.2999,0.5135]
[7,56,"202043_S_AT","SMS","spermine synthase","---","---","methionine metabolic process /// polyamine metabolic process","catalytic activity /// spermidine synthase activity /// transferase activity /// spermine synthase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",7.8529,-1,0,0,-0.2614,0.5712]
[7,57,"211686_S_AT","RBM13","RNA binding motif protein 13","---","---","---","---","---","unknown",7.1121,-1,0,0,-0.0734,0.8757]
[7,58,"221751_AT","SLC2A3P1","Solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1","---","---","---","---","---","unknown",7.0169,-1,0,0,0.15,0.7481]
[7,59,"221230_S_AT","ARID4B","AT rich interactive domain 4B (RBP1-like)","---","---","chromatin assembly or disassembly /// transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// chromatin binding","chromatin /// intracellular /// nucleus /// cytoplasm","dna repair,transcription",17.5255,1,0,0,-0.1603,0.7314]
[7,60,"218016_S_AT","POLR3E","polymerase (RNA) III (DNA directed) polypeptide E (80kD)","RNA_transcription_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_RNA_transcription_Reactome/Hs_RNA_transcription_Reactome.htm","transcription","DNA-directed RNA polymerase activity","nucleus","dna repair,transcription",5.5757,-1,1.3848,0,-0.113,0.8094]
[7,61,"201038_S_AT","ANP32A","Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A","---","---","nucleocytoplasmic transport /// nucleocytoplasmic transport /// intracellular signaling cascade","protein binding /// protein binding","nucleus /// cytoplasm /// cytoplasm /// cytoplasm /// endoplasmic reticulum /// perinuclear region of cytoplasm","transport,ion channel",5.7742,-1,1.8883,0,0.1399,0.7648]
[7,62,"212434_AT","GRPEL1","GrpE-like 1, mitochondrial (E. coli)","---","---","protein folding /// protein import into mitochondrial matrix","adenyl-nucleotide exchange factor activity /// protein binding /// protein homodimerization activity /// unfolded protein binding /// chaperone binding","mitochondrion /// mitochondrial matrix",null,3.9386,-1,1.6849,0,-0.1179,0.8013]
[7,63,"221478_AT","BNIP3L","BCL2/adenovirus E1B 19kDa interacting protein 3-like","Apoptosis /// Apoptosis /// Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","apoptosis /// induction of apoptosis /// negative regulation of survival gene product activity /// positive regulation of apoptosis /// negative regulation of apoptosis /// defense response to virus","protein binding /// lamin binding /// protein homodimerization activity /// protein heterodimerization activity","nuclear envelope /// mitochondrion /// mitochondrion /// mitochondrial envelope /// endoplasmic reticulum /// endoplasmic reticulum /// membrane /// integral to membrane /// intrinsic to membrane","apoptosis",3.5548,-1,1.7772,0,-0.4907,0.2635]
[7,64,"209685_S_AT","PRKCB1","protein kinase C, beta 1","Calcium_regulation_in_cardiac_cells /// G_Protein_Signaling /// Smooth_muscle_contraction /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","protein amino acid phosphorylation /// protein amino acid phosphorylation /// calcium ion transport /// cellular calcium ion homeostasis /// signal transduction /// intracellular signaling cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein kinase C activity /// protein kinase C activity /// calcium channel regulator activity /// calcium ion binding /// protein binding /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding","nucleus /// cytoplasm /// cytoplasm /// plasma membrane /// membrane","transport,ion channel:signal transduction,signaling pathway",1.3258,-1,0.7177,0,-0.687,0.0881]
[7,65,"218984_AT","PUS7","pseudouridylate synthase 7 homolog (S. cerevisiae)","---","---","tRNA processing","pseudouridylate synthase activity /// isomerase activity","---",null,5.5374,-1,1.4786,0,-0.0748,0.8734]
[7,66,"213376_AT","ZBTB1","zinc finger and BTB domain containing 1","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// protein binding /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription",13.7817,1,0.0007,0,0.2042,0.6605]
[7,67,"207250_AT","SIX6","SIX homeobox 6","---","---","regulation of transcription, DNA-dependent /// multicellular organismal development /// visual perception /// organ morphogenesis /// regulation of transcription","DNA binding /// transcription factor activity /// protein binding /// sequence-specific DNA binding","nucleus","dna repair,transcription",8.9167,-1,0,0,-0.2142,0.6446]
[7,68,"202540_S_AT","HMGCR","3-hydroxy-3-methylglutaryl-Coenzyme A reductase","Cholesterol_Biosynthesis /// Statin_Pathway_PharmGKB","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm","lipid metabolic process /// steroid biosynthetic process /// cholesterol biosynthetic process /// cholesterol metabolic process /// germ cell migration /// gonad development /// lipid biosynthetic process /// biosynthetic process /// sterol biosynthetic process","hydroxymethylglutaryl-CoA reductase (NADPH) activity /// oxidoreductase activity","membrane fraction /// peroxisome /// endoplasmic reticulum /// endoplasmic reticulum membrane /// endoplasmic reticulum membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",8.8292,-1,0,0,0.1063,0.8206]
[7,69,"202539_S_AT","HMGCR","3-hydroxy-3-methylglutaryl-Coenzyme A reductase","Cholesterol_Biosynthesis /// Statin_Pathway_PharmGKB","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm","lipid metabolic process /// steroid biosynthetic process /// cholesterol biosynthetic process /// cholesterol metabolic process /// germ cell migration /// gonad development /// lipid biosynthetic process /// biosynthetic process /// sterol biosynthetic process","hydroxymethylglutaryl-CoA reductase (NADPH) activity /// oxidoreductase activity","membrane fraction /// peroxisome /// endoplasmic reticulum /// endoplasmic reticulum membrane /// endoplasmic reticulum membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",9.8411,-1,0,0,0.2639,0.5675]
[]
[null,null,8]
[8,1,"201332_S_AT","STAT6","signal transducer and activator of transcription 6, interleukin-4 induced","---","---","negative regulation of T-helper 2 type immune response /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// signal transduction /// signal transduction /// intracellular signaling cascade /// regulation of cell proliferation /// positive regulation of transcription from RNA polymerase II promoter /// positive regulation of isotype switching to IgE isotypes","DNA binding /// transcription factor activity /// transcription factor activity /// signal transducer activity /// calcium ion binding /// protein binding /// sequence-specific DNA binding","nucleus /// cytoplasm","dna repair,transcription:cell cycle,proliferation:immune response:signal transduction,signaling pathway",2.2083,-1,0.9182,-1,0.8001,0.0307]
[8,2,"202585_S_AT","NFX1","nuclear transcription factor, X-box binding 1","---","---","negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// ubiquitin cycle /// inflammatory response","nucleic acid binding /// DNA binding /// transcription factor activity /// transcription factor activity /// protein binding /// zinc ion binding /// ligase activity /// metal ion binding","nucleus","dna repair,transcription",3.5509,-1,0,1,0.7689,0.0434]
[8,3,"204061_AT","PRKX","protein kinase, X-linked","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// cAMP-dependent protein kinase activity /// protein-tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity","---",null,3.5124,-1,0,-2,0.8951,0.0065]
[8,4,"201465_S_AT","JUN","jun oncogene","Apoptosis /// Apoptosis_GenMAPP /// MAPK_Cascade /// Smooth_muscle_contraction /// TGF_Beta_Signaling_Pathway /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_MAPK_Cascade/Hs_MAPK_Cascade.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","regulation of progression through cell cycle /// transcription /// regulation of transcription, DNA-dependent /// cellular process /// leading edge cell differentiation /// regulation of transcription /// positive regulation of transcription from RNA polymerase II promoter","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// RNA polymerase II transcription factor activity /// protein binding /// protein binding /// sequence-specific DNA binding /// protein dimerization activity","nuclear chromosome /// nucleus /// transcription factor complex","dna repair,transcription:cell growth,differentiation:cell cycle,proliferation",3.9493,-1,0.496,0,0.214,0.645]
[8,5,"217373_X_AT","MDM2","Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)","Apoptosis /// Apoptosis_GenMAPP /// Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// negative regulation of transcription from RNA polymerase II promoter /// protein complex assembly /// ubiquitin cycle /// negative regulation of cell proliferation /// protein ubiquitination /// regulation of protein catabolic process","ubiquitin-protein ligase activity /// protein binding /// protein binding /// zinc ion binding /// zinc ion binding /// ligase activity /// negative regulator of basal transcription activity /// enzyme binding /// metal ion binding","intracellular /// nucleus /// nucleoplasm /// nucleolus /// cytoplasm","dna repair,transcription:cell cycle,proliferation",2.5517,-1,0,1,0.7957,0.0323]
[8,6,"204197_S_AT","RUNX3","runt-related transcription factor 3","TGF_Beta_Signaling_Pathway /// TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// induction of apoptosis /// cell proliferation /// negative regulation of progression through cell cycle /// negative regulation of epithelial cell proliferation","DNA binding /// transcription factor activity /// transcription factor activity /// protein binding /// ATP binding /// ATP binding","nucleus /// nucleus","dna repair,transcription:apoptosis:cell cycle,proliferation",3.1638,-1,0.6877,0,0.8256,0.0222]
[8,7,"200730_S_AT","PTP4A1","protein tyrosine phosphatase type IVA, member 1","---","---","protein amino acid dephosphorylation /// cell cycle /// multicellular organismal development /// dephosphorylation","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// hydrolase activity /// phosphoric monoester hydrolase activity","cytoplasm /// endosome /// endoplasmic reticulum /// membrane","cell cycle,proliferation",3.3108,-1,1.8909,0,0.6826,0.0911]
[8,8,"218219_S_AT","LANCL2","LanC lantibiotic synthetase component C-like 2 (bacterial)","---","---","negative regulation of transcription","ATP binding /// GTP binding","nucleus /// cytoplasm /// cytosol /// plasma membrane /// membrane","dna repair,transcription",3.6428,-1,1.3006,-2,0.885,0.0081]
[8,9,"209279_S_AT","NSDHL","NAD(P) dependent steroid dehydrogenase-like","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","hair follicle development /// steroid biosynthetic process /// cholesterol biosynthetic process /// cholesterol biosynthetic process /// cholesterol metabolic process /// lipid biosynthetic process /// sterol biosynthetic process","3-beta-hydroxy-delta5-steroid dehydrogenase activity /// 3-beta-hydroxy-delta5-steroid dehydrogenase activity /// steroid delta-isomerase activity /// oxidoreductase activity /// sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",4.0909,1,0,-1,0.6115,0.1445]
[8,10,"64488_AT","---","CDNA FLJ38849 fis, clone MESAN2008936","---","---","---","---","---","unknown",3.9389,-1,0,-3,0.5189,0.2328]
[8,11,"209239_AT","NFKB1","nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG /// Smooth_muscle_contraction /// TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// apoptosis /// anti-apoptosis /// inflammatory response /// signal transduction /// negative regulation of interleukin-12 biosynthetic process /// regulation of transcription /// negative regulation of transcription, DNA-dependent /// positive regulation of transcription /// positive regulation of transcription from RNA polymerase II promoter","DNA binding /// transcription factor activity /// transcription factor activity /// protein binding /// protein binding /// specific transcriptional repressor activity","nucleus /// nucleus /// nucleus /// cytoplasm /// cytoplasm","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:signal transduction,signaling pathway",3.6882,-1,1.1216,0,0.7783,0.0393]
[8,12,"210405_X_AT","TNFRSF10B","tumor necrosis factor receptor superfamily, member 10b","Apoptosis /// Apoptosis /// Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","electron transport /// apoptosis /// apoptosis /// caspase activation /// signal transduction /// cell surface receptor linked signal transduction /// activation of NF-kappaB-inducing kinase /// induction of apoptosis via death domain receptors /// regulation of apoptosis /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// receptor activity /// receptor activity /// protein binding /// protein binding /// caspase activator activity /// electron carrier activity /// TRAIL binding /// iron-sulfur cluster binding","membrane /// integral to membrane /// integral to membrane","transport,ion channel:apoptosis:signal transduction,signaling pathway",3.1484,-1,0,-3,0.7397,0.0574]
[8,13,"214062_X_AT","NFKBIB","nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta","Apoptosis /// Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","transcription /// signal transduction","transcription coactivator activity /// signal transducer activity /// receptor activity /// protein binding","cytoplasm","dna repair,transcription:signal transduction,signaling pathway",4.2563,-1,0,-2,0.7805,0.0384]
[8,14,"213479_AT","NPTX2","neuronal pentraxin II","---","---","synaptic transmission","calcium ion binding /// sugar binding /// metal ion binding","---",null,5.0915,-1,0.7,-2,0.7327,0.0611]
[8,15,"36564_AT","RNF19B","ring finger protein 19B","---","---","---","protein binding /// zinc ion binding /// metal ion binding","membrane /// integral to membrane","unknown",4.8642,-1,0,-3,0.8985,0.006]
[8,16,"203579_S_AT","SLC7A6","solute carrier family 7 (cationic amino acid transporter, y+ system), member 6","---","---","protein complex assembly /// amino acid metabolic process /// transport /// transport /// amino acid transport /// histone methylation /// peptidyl-arginine methylation /// regulation of protein binding","methyltransferase activity /// histone-arginine N-methyltransferase activity /// S-adenosylmethionine-dependent methyltransferase activity /// amino acid transmembrane transporter activity /// amino acid transmembrane transporter activity /// [myelin basic protein]-arginine N-methyltransferase activity /// transferase activity /// protein-arginine omega-N monomethyltransferase activity /// protein-arginine omega-N symmetric methyltransferase activity /// histone binding","nucleus /// cytoplasm /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",4.2068,-1,0,-1,0.7818,0.0378]
[8,17,"209324_S_AT","RGS16","regulator of G-protein signaling 16","Calcium_regulation_in_cardiac_cells /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","visual perception /// regulation of G-protein coupled receptor protein signaling pathway /// negative regulation of signal transduction","signal transducer activity /// GTPase activator activity /// calmodulin binding","---","signal transduction,signaling pathway",3.5064,-1,0.864,-2,0.7215,0.0672]
[8,18,"213038_AT","RNF19B","ring finger protein 19B","---","---","---","protein binding /// zinc ion binding /// metal ion binding","membrane /// integral to membrane","unknown",6.0912,-1,0,-3,0.8661,0.0117]
[8,19,"212793_AT","DAAM2","dishevelled associated activator of morphogenesis 2","---","---","cellular component organization and biogenesis /// actin cytoskeleton organization and biogenesis","actin binding /// Rho GTPase binding","---","nuclear matrix,cytoskeleton",6.8441,-1,1.2732,-1,0.8392,0.0182]
[8,20,"213030_S_AT","PLXNA2","plexin A2","---","---","multicellular organismal development","receptor activity","membrane /// integral to membrane",null,7.1326,1,0,-2,0.6086,0.147]
[]
[null,null,9]
[9,1,"213187_X_AT","FTL","ferritin, light polypeptide","---","---","skeletal development /// ossification /// regulation of translation /// iron ion transport /// cellular iron ion homeostasis /// cellular iron ion homeostasis /// pinocytosis /// acute-phase response /// cell growth /// regulation of striated muscle development /// neuron differentiation /// regulation of bone mineralization /// regulation of bone mineralization /// negative regulation of bone mineralization /// negative regulation of bone mineralization /// negative regulation of insulin receptor signaling pathway /// regulation of inflammatory response /// positive regulation of phagocytosis","cysteine protease inhibitor activity /// binding /// iron ion binding /// iron ion binding /// protein binding /// protein binding /// ferric iron binding /// oxidoreductase activity /// kinase inhibitor activity /// identical protein binding /// metal ion binding /// transition metal ion binding","extracellular region /// extracellular space /// intracellular /// cytoplasm /// ferritin complex","cell growth,differentiation:transport,ion channel:signal transduction,signaling pathway",0.4378,1,1.5551,1,0.5114,0.2408]
[9,2,"210774_S_AT","NCOA4","nuclear receptor coactivator 4","Circadian_Exercise /// Circadian_Exercise /// Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","transcription /// regulation of transcription, DNA-dependent /// transmembrane receptor protein tyrosine kinase signaling pathway /// male gonad development /// androgen receptor signaling pathway /// positive regulation of transcription, DNA-dependent","transcription coactivator activity /// transcription coactivator activity /// receptor activity /// protein binding /// androgen receptor binding","nucleus","dna repair,transcription:signal transduction,signaling pathway",0.3703,1,0,0,-0.0418,0.929]
[9,3,"216526_X_AT","HLA-C","major histocompatibility complex, class I, C","Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","ciliary or flagellar motility /// antigen processing and presentation of peptide antigen via MHC class I /// immune response /// immune response /// antigen processing and presentation","microtubule motor activity /// MHC class I receptor activity /// MHC class II receptor activity","axonemal dynein complex /// integral to plasma membrane /// membrane /// membrane /// integral to membrane /// MHC class I protein complex","immune response",0.2712,1,1.3601,1,0.6972,0.0817]
[9,4,"214459_X_AT","HLA-C","major histocompatibility complex, class I, C","Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","ciliary or flagellar motility /// antigen processing and presentation of peptide antigen via MHC class I /// immune response /// immune response /// antigen processing and presentation","microtubule motor activity /// MHC class I receptor activity /// MHC class II receptor activity","axonemal dynein complex /// integral to plasma membrane /// membrane /// membrane /// integral to membrane /// MHC class I protein complex","immune response",0.2144,1,0.001,3,0.8334,0.0199]
[9,5,"201477_S_AT","RRM1","ribonucleotide reductase M1 polypeptide","Nucleotide_Metabolism","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Nucleotide_Metabolism/Hs_Nucleotide_Metabolism.htm","DNA replication /// DNA replication","nucleotide binding /// catalytic activity /// ribonucleoside-diphosphate reductase activity /// ribonucleoside-diphosphate reductase activity /// ATP binding /// oxidoreductase activity","cytoplasm /// ribonucleoside-diphosphate reductase complex /// ribonucleoside-diphosphate reductase complex","dna replication",0.2933,1,0,3,0.0503,0.9147]
[9,6,"217732_S_AT","ITM2B","integral membrane protein 2B","---","---","nervous system development /// sensory perception of sound","---","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane",null,0.0382,1,0,1,0.207,0.6561]
[9,7,"201890_AT","RRM2","ribonucleotide reductase M2 polypeptide","---","---","DNA replication /// DNA replication /// deoxyribonucleoside diphosphate metabolic process /// deoxyribonucleotide metabolic process","ribonucleoside-diphosphate reductase activity /// ribonucleoside-diphosphate reductase activity /// iron ion binding /// protein binding /// oxidoreductase activity /// metal ion binding /// transition metal ion binding","cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:dna replication",0.4321,-1,0,1,0.1054,0.8221]
[9,8,"214870_X_AT","LOC339047 /// LOC642799 /// NPIP","nuclear pore complex interacting protein /// hypothetical protein LOC339047 /// similar to nuclear pore complex interacting protein","---","---","protein targeting /// transport /// neuropeptide signaling pathway /// protein transport /// mRNA transport","---","nuclear pore /// membrane /// integral to membrane","transport,ion channel:signal transduction,signaling pathway",0.3517,1,1.2757,-1,0.434,0.3305]
[9,9,"201012_AT","ANXA1","annexin A1","Prostaglandin_synthesis_regulation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Prostaglandin_synthesis_regulation/Hs_Prostaglandin_synthesis_regulation.htm","lipid metabolic process /// anti-apoptosis /// cell motility /// inflammatory response /// cell cycle /// signal transduction /// signal transduction /// cell surface receptor linked signal transduction /// peptide cross-linking /// keratinocyte differentiation /// regulation of cell proliferation /// arachidonic acid secretion","phospholipase inhibitor activity /// phospholipase inhibitor activity /// receptor binding /// structural molecule activity /// calcium ion binding /// calcium ion binding /// protein binding /// protein binding /// phospholipid binding /// calcium-dependent phospholipid binding /// phospholipase A2 inhibitor activity /// protein binding, bridging","cornified envelope /// cytoplasm /// sarcolemma","cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:cell cycle,proliferation:signal transduction,signaling pathway",1.047,1,0.0006,-1,0.9383,0.0018]
[9,10,"205436_S_AT","H2AFX","H2A histone family, member X","Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","double-strand break repair via homologous recombination /// DNA repair /// DNA recombination /// nucleosome assembly /// nucleosome assembly /// response to DNA damage stimulus /// chromosome organization and biogenesis (sensu Eukaryota) /// chromosome organization and biogenesis (sensu Eukaryota) /// cell cycle /// meiosis /// spermatogenesis","DNA binding /// DNA binding /// damaged DNA binding /// protein binding","chromatin /// nucleosome /// nucleosome /// nucleus /// nucleus /// replication fork /// chromosome","dna repair,transcription:cell cycle,proliferation",2.0111,1,0,0,-0.6173,0.1397]
[9,11,"218883_S_AT","MLF1IP","MLF1 interacting protein","---","---","transcription /// regulation of transcription, DNA-dependent","---","chromosome, pericentric region /// chromosome /// cytoplasm","dna repair,transcription",0.2891,1,0.9738,0,0.252,0.5857]
[9,12,"210487_AT","DNTT","deoxynucleotidyltransferase, terminal","---","---","DNA metabolic process /// DNA metabolic process /// DNA replication /// DNA modification","magnesium ion binding /// DNA binding /// DNA-directed DNA polymerase activity /// DNA nucleotidylexotransferase activity /// DNA nucleotidylexotransferase activity /// transferase activity /// nucleotidyltransferase activity /// metal ion binding","intracellular","biosynthesis,metabolism,metabolic process,biosynthetic process:dna replication",1.0601,-1,0,0,-0.8679,0.0113]
[9,13,"203554_X_AT","PTTG1","pituitary tumor-transforming 1","Cell_cycle_KEGG /// Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","DNA metabolic process /// DNA repair /// transcription from RNA polymerase II promoter /// response to DNA damage stimulus /// cell cycle /// chromosome segregation /// mitosis /// spermatogenesis /// homologous chromosome segregation /// chromosome organization and biogenesis /// cell division","transcription factor activity /// cysteine protease inhibitor activity /// cysteine protease inhibitor activity /// protein binding","nucleus /// nucleus /// cytoplasm /// cytoplasm","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",0.5878,-1,0,0,-0.8967,0.0062]
[9,14,"208308_S_AT","GPI","glucose phosphate isomerase","Glycolysis_and_Gluconeogenesis /// Glycolysis_and_Gluconeogenesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm","carbohydrate metabolic process /// gluconeogenesis /// glycolysis /// humoral immune response /// nervous system development /// hemostasis","glucose-6-phosphate isomerase activity /// cytokine activity /// growth factor activity /// isomerase activity","extracellular space /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:immune response",1.2242,-1,0,0,0.3118,0.4961]
[9,15,"204386_S_AT","MRP63","mitochondrial ribosomal protein 63","---","---","translation","structural constituent of ribosome","mitochondrion /// mitochondrial ribosome /// ribonucleoprotein complex",null,0.4127,1,1.8761,0,-0.2646,0.5664]
[9,16,"213603_S_AT","RAC2","ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)","Integrin-mediated_cell_adhesion_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm","chemotaxis /// signal transduction /// small GTPase mediated signal transduction /// cell projection biogenesis /// actin cytoskeleton organization and biogenesis","nucleotide binding /// GTPase activity /// GTPase activity /// protein binding /// GTP binding","intracellular /// membrane fraction /// nuclear envelope /// cytoplasm","nuclear matrix,cytoskeleton:signal transduction,signaling pathway",2.1831,-1,0,0,-0.7438,0.0553]
[9,17,"211762_S_AT","KPNA2","karyopherin alpha 2 (RAG cohort 1, importin alpha 1)","---","---","regulation of DNA recombination /// M phase specific microtubule process /// G2 phase of mitotic cell cycle /// DNA metabolic process /// protein import into nucleus /// NLS-bearing substrate import into nucleus /// transport /// intracellular protein transport /// protein transport","binding /// protein binding /// protein binding /// nuclear localization sequence binding /// protein transporter activity","nucleus /// nucleus /// nuclear pore /// nucleoplasm /// cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:cell cycle,proliferation",1.8679,-1,0,0,-0.9193,0.0034]
[9,18,"204759_AT","RCBTB2","regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2","---","---","---","Ran guanyl-nucleotide exchange factor activity /// protein binding","---","unknown",1.5467,-1,0,0,-0.9148,0.0039]
[9,19,"201626_AT","INSIG1","insulin induced gene 1","---","---","lipid metabolic process /// metabolic process /// steroid metabolic process /// cholesterol metabolic process /// cell proliferation","---","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",0.5827,-1,0,0,0.1929,0.6785]
[9,20,"218039_AT","NUSAP1","nucleolar and spindle associated protein 1","---","---","mitotic sister chromatid segregation /// cytokinesis after mitosis /// mitotic chromosome condensation /// establishment of mitotic spindle localization /// positive regulation of mitosis","---","---",null,2.279,1,0,0,-0.6561,0.1095]
[9,21,"203752_S_AT","JUND","jun D proto-oncogene","Hypertrophy_model","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// regulation of transcription","DNA binding /// transcription factor activity /// RNA polymerase II transcription factor activity /// sequence-specific DNA binding /// protein dimerization activity","chromatin /// nucleus","dna repair,transcription",2.4195,1,0,0,0.6247,0.1337]
[9,22,"201292_AT","TOP2A","topoisomerase (DNA) II alpha 170kDa","---","---","DNA metabolic process /// DNA replication /// DNA topological change /// DNA ligation /// DNA repair /// response to DNA damage stimulus /// chromosome segregation /// apoptotic chromosome condensation /// positive regulation of apoptosis /// positive regulation of viral genome replication /// positive regulation of retroviral genome replication /// phosphoinositide-mediated signaling","nucleotide binding /// DNA binding /// DNA binding /// chromatin binding /// DNA topoisomerase activity /// DNA topoisomerase (ATP-hydrolyzing) activity /// DNA topoisomerase (ATP-hydrolyzing) activity /// protein kinase C binding /// protein binding /// ATP binding /// protein C-terminus binding /// DNA-dependent ATPase activity /// drug binding /// isomerase activity /// enzyme binding /// protein homodimerization activity /// histone deacetylase binding /// ubiquitin binding /// protein heterodimerization activity","nucleus /// nucleus /// nucleoplasm /// chromosome /// chromosome /// nucleolus /// cytoplasm /// centriole /// DNA topoisomerase complex (ATP-hydrolyzing) /// viral integration complex /// protein complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:dna replication",3.2295,-1,0,0,-0.7684,0.0436]
[]
[null,null,10]
[10,1,"214041_X_AT","RPL37A","Ribosomal protein L37a","---","---","translation","structural constituent of ribosome /// protein binding /// zinc ion binding /// metal ion binding","intracellular /// ribosome /// ribonucleoprotein complex",null,0.4914,1,0.2956,4,0.7843,0.0368]
[10,2,"202648_AT","---","---","---","---","---","---","---","unknown",0.8562,1,0.4616,2,0.7049,0.0769]
[10,3,"211697_X_AT","PNO1","partner of NOB1 homolog (S. cerevisiae)","---","---","---","RNA binding","nucleolus","unknown",3.8858,1,1.7465,6,0.5109,0.2413]
[10,4,"206438_X_AT","TCTN2","tectonic family member 2","---","---","---","---","membrane /// integral to membrane","unknown",15.6337,-1,0,6,0.3058,0.5048]
[10,5,"216153_X_AT","RECK","reversion-inducing-cysteine-rich protein with kazal motifs","---","---","cell cycle /// negative regulation of progression through cell cycle","endopeptidase inhibitor activity /// endopeptidase inhibitor activity /// serine-type endopeptidase inhibitor activity /// protein binding /// metalloendopeptidase inhibitor activity /// GPI anchor binding","peripheral to membrane of membrane fraction /// membrane fraction /// membrane","cell cycle,proliferation",3.6788,1,0,6,0.3037,0.5079]
[10,6,"209057_X_AT","CDC5L","CDC5 cell division cycle 5-like (S. pombe)","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// mRNA processing /// cell cycle /// RNA splicing /// regulation of transcription","DNA binding /// DNA binding /// RNA binding /// protein binding","nucleus /// nucleus /// spliceosome /// cytoplasm","dna repair,transcription:cell cycle,proliferation",7.6408,-1,0,4,0.4152,0.3543]
[10,7,"220725_X_AT","DNAH3","Dynein, axonemal, heavy chain 3","---","---","ciliary or flagellar motility /// microtubule-based movement","nucleotide binding /// microtubule motor activity /// microtubule motor activity /// ATP binding /// ATPase activity /// nucleoside-triphosphatase activity","axonemal dynein complex /// dynein complex",null,2.5049,1,1.5542,6,0.3979,0.3767]
[]
[null,null,11]
[11,1,"221972_S_AT","SDF4","stromal cell derived factor 4","---","---","---","calcium ion binding","---","unknown",6.117,1,1.3634,0,0.0214,0.9637]
[11,2,"204809_AT","CLPX","ClpX caseinolytic peptidase X homolog (E. coli)","---","---","protein folding /// protein folding /// protein transport","nucleotide binding /// protein binding /// protein binding /// ATP binding /// zinc ion binding /// ATPase activity /// nucleoside-triphosphatase activity /// ATPase activity, coupled /// metal ion binding","mitochondrion /// mitochondrion /// mitochondrial inner membrane","transport,ion channel",9.0659,1,0,0,-0.3377,0.4588]
[11,3,"209882_AT","RIT1","Ras-like without CAAX 1","---","---","signal transduction /// small GTPase mediated signal transduction","nucleotide binding /// protein binding /// protein binding /// calmodulin binding /// GTP binding /// GTP binding","intracellular /// plasma membrane /// plasma membrane /// membrane","signal transduction,signaling pathway",4.7658,1,0,-4,-0.3721,0.4111]
[11,4,"202654_X_AT","2008-03-07","membrane-associated ring finger (C3HC4) 7","---","---","ubiquitin cycle","protein binding /// zinc ion binding /// ligase activity /// metal ion binding","---",null,9.2572,1,0,-4,-0.3871,0.391]
[11,5,"218940_AT","C14orf138","chromosome 14 open reading frame 138","---","---","---","---","---","unknown",5.8906,1,0.5935,2,-0.3497,0.4419]
[11,6,"218640_S_AT","PLEKHF2","pleckstrin homology domain containing, family F (with FYVE domain) member 2","---","---","---","zinc ion binding /// metal ion binding","transport vesicle","unknown",8.2699,1,0,-4,-0.4896,0.2647]
[11,7,"219165_AT","PDLIM2","PDZ and LIM domain 2 (mystique)","---","---","---","protein binding /// zinc ion binding /// metal ion binding","cytoplasm /// cytoskeleton /// cell surface","unknown",8.0478,1,0,-2,-0.5562,0.1948]
[11,8,"201409_S_AT","PPP1CB","protein phosphatase 1, catalytic subunit, beta isoform","G13_Signaling_Pathway /// G13_Signaling_Pathway /// G13_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G13_Signaling_Pathway/Hs_G13_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/cellular_process-GenMAPP/Mm_G13_Signaling_Pathway/Mm_G13_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/cellular_process-GenMAPP/Rn_G13_Signaling_Pathway/Rn_G13_Signaling_Pathway.htm","G1/S transition of mitotic cell cycle /// carbohydrate metabolic process /// glycogen metabolic process /// protein amino acid dephosphorylation /// response to DNA damage stimulus /// response to DNA damage stimulus /// cell cycle /// multicellular organismal development /// positive regulation of cell proliferation /// cell division","protein phosphatase type 1 activity /// phosphoprotein phosphatase activity /// iron ion binding /// protein binding /// protein binding /// hydrolase activity /// protein kinase binding /// manganese ion binding /// metal ion binding","nucleus /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",9.2436,1,0,-4,-0.367,0.418]
[11,9,"37577_AT","ARHGAP19","Rho GTPase activating protein 19","---","---","signal transduction /// G-protein coupled receptor protein signaling pathway /// multicellular organismal development /// nervous system development /// nervous system development /// axon guidance /// brain development /// cell differentiation","follicle-stimulating hormone receptor activity /// GTPase activator activity /// calcium ion binding /// calcium ion binding /// protein binding /// protein binding","extracellular space /// intracellular /// integral to membrane","cell growth,differentiation:signal transduction,signaling pathway",9.8661,1,0,-4,-0.9518,0.001]
[11,10,"210986_S_AT","TPM1","tropomyosin 1 (alpha)","Striated_muscle_contraction /// Striated_muscle_contraction /// Striated_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Striated_muscle_contraction/Hs_Striated_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Striated_muscle_contraction/Hs_Striated_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Striated_muscle_contraction/Hs_Striated_muscle_contraction.htm","cell motility /// regulation of muscle contraction /// regulation of heart contraction","translation initiation factor activity /// actin binding /// structural constituent of cytoskeleton /// structural constituent of muscle","cytoplasm /// cytoskeleton /// cytoskeleton /// muscle thin filament tropomyosin",null,9.3449,1,0,2,-0.7831,0.0373]
[11,11,"204523_AT","ZNF140","zinc finger protein 140","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// transcription factor activity /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription",5.0296,1,0,0,0.3053,0.5055]
[11,12,"206854_S_AT","MAP3K7","mitogen-activated protein kinase kinase kinase 7","---","---","positive regulation of T cell cytokine production /// protein amino acid phosphorylation /// transforming growth factor beta receptor signaling pathway /// activation of NF-kappaB-inducing kinase /// T cell receptor signaling pathway /// positive regulation of T cell activation","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// MAP kinase kinase kinase activity /// protein-tyrosine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// metal ion binding","---","signal transduction,signaling pathway",7.6679,1,1.3964,0,-0.3132,0.494]
[11,13,"218848_AT","THOC6","THO complex 6 homolog (Drosophila)","---","---","---","---","---","unknown",8.5158,1,0,0,-0.0966,0.8368]
[11,14,"203313_S_AT","TGIF1","TGFB-induced factor homeobox 1","TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// transcription corepressor activity /// protein binding /// sequence-specific DNA binding","nucleus","dna repair,transcription",12.5618,1,0,-4,-0.7739,0.0412]
[11,15,"217672_X_AT","---","---","---","---","---","---","---","unknown",5.2095,1,1.081,-2,-0.1071,0.8192]
[11,16,"204278_S_AT","EBAG9","estrogen receptor binding site associated, antigen, 9","---","---","regulation of cell growth /// apoptosis","receptor activity /// apoptotic protease activator activity","soluble fraction /// membrane /// integral to membrane /// integral to membrane","cell growth,differentiation:apoptosis",9.9446,1,0,-4,-0.3082,0.5012]
[11,17,"215030_AT","GRSF1","G-rich RNA sequence binding factor 1","---","---","mRNA polyadenylation /// anterior/posterior pattern formation /// morphogenesis of embryonic epithelium","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// mRNA binding","cytoplasm /// cytoplasm",null,9.9795,1,0,0,-0.3847,0.3941]
[11,18,"218989_X_AT","SLC30A5","solute carrier family 30 (zinc transporter), member 5","---","---","cation transport /// cobalt ion transport /// zinc ion transport /// cellular zinc ion homeostasis /// response to zinc ion /// regulation of proton transport","zinc ion transmembrane transporter activity /// zinc ion binding /// cation transmembrane transporter activity","membrane fraction /// membrane fraction /// Golgi apparatus /// integral to plasma membrane /// membrane /// apical plasma membrane /// secretory granule","transport,ion channel",8.635,1,0,-2,-0.3025,0.5096]
[11,19,"222119_S_AT","FBXO11","F-box protein 11","---","---","ubiquitin-dependent protein catabolic process /// ubiquitin cycle /// protein ubiquitination","ubiquitin-protein ligase activity /// ubiquitin-protein ligase activity /// protein binding /// zinc ion binding /// metal ion binding","ubiquitin ligase complex",null,10.2659,1,0,-2,-0.6078,0.1476]
[11,20,"200995_AT","IPO7","Importin 7","---","---","protein import into nucleus, docking /// protein import into nucleus /// transport /// intracellular protein transport /// signal transduction /// protein transport","small GTPase regulator activity /// transporter activity /// binding /// protein binding /// protein binding /// protein binding /// Ran GTPase binding /// protein transporter activity /// histone binding","soluble fraction /// nucleus /// nuclear pore /// nuclear pore /// cytoplasm","transport,ion channel:signal transduction,signaling pathway",7.934,1,1.8746,-2,-0.1483,0.751]
[11,21,"209388_AT","PAPOLA","poly(A) polymerase alpha","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","transcription /// mRNA polyadenylation /// mRNA processing /// RNA polyadenylation","RNA binding /// RNA binding /// polynucleotide adenylyltransferase activity /// transferase activity /// nucleotidyltransferase activity","nucleus /// nucleus /// cytoplasm /// cytoplasm","dna repair,transcription",7.3917,1,0,2,-0.342,0.4528]
[11,22,"202950_AT","CRYZ","crystallin, zeta (quinone reductase)","---","---","visual perception","NADPH:quinone reductase activity /// zinc ion binding /// oxidoreductase activity","cytoplasm",null,10.0843,1,0,2,-0.6383,0.1229]
[11,23,"218224_AT","PNMA1","paraneoplastic antigen MA1","---","---","spermatogenesis /// central nervous system development","protein binding","nucleolus /// cytoplasm",null,10.7687,1,0,-2,-0.5424,0.2085]
[11,24,"202969_AT","---","MRNA; cDNA DKFZp667B0924 (from clone DKFZp667B0924)","---","---","---","---","---","unknown",8.799,1,0,0,-0.566,0.1854]
[11,25,"221264_S_AT","TARDBP","TAR DNA binding protein","---","---","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// mRNA processing /// mitosis /// RNA splicing","nucleotide binding /// nucleic acid binding /// DNA binding /// transcription factor activity /// RNA binding /// protein binding /// microtubule binding","nucleus /// nucleus","dna repair,transcription",9.1592,1,0,-2,-0.5202,0.2313]
[11,26,"202979_S_AT","CREBZF","CREB/ATF bZIP transcription factor","---","---","transcription /// transcription /// regulation of transcription, DNA-dependent /// response to virus /// negative regulation of transcription /// negative regulation of gene expression, epigenetic /// regulation of transcription factor activity","DNA binding /// transcription factor activity /// protein binding /// specific transcriptional repressor activity /// sequence-specific DNA binding /// protein dimerization activity","nucleus /// nucleus","dna repair,transcription",8.1377,1,0,-2,-0.4921,0.262]
[11,27,"201634_S_AT","CYB5B","cytochrome b5 type B (outer mitochondrial membrane)","---","---","electron transport /// transport","iron ion binding /// heme binding /// metal ion binding /// transition metal ion binding","mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane /// outer membrane","transport,ion channel",7.5567,1,0,2,-0.238,0.6073]
[11,28,"212648_AT","DHX29","DEAH (Asp-Glu-Ala-His) box polypeptide 29","---","---","---","nucleotide binding /// nucleic acid binding /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","---","unknown",9.4185,1,1.4112,-2,-0.5355,0.2154]
[11,29,"212476_AT","CENTB2","centaurin, beta 2","---","---","regulation of GTPase activity","GTPase activator activity /// zinc ion binding /// metal ion binding","---",null,11.4294,1,0,0,-0.7936,0.0331]
[11,30,"219848_S_AT","ZNF432","zinc finger protein 432","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription",5.4402,1,0,-4,0.0612,0.8962]
[11,31,"222062_AT","IL27RA","interleukin 27 receptor, alpha","---","---","positive regulation of T-helper 1 type immune response /// negative regulation of T-helper 2 type immune response /// immune response /// cell surface receptor linked signal transduction /// positive regulation of interferon-gamma production /// regulation of isotype switching to IgG isotypes /// defense response to Gram-positive bacterium","receptor activity /// transmembrane receptor activity /// protein binding /// interleukin-27 receptor activity","integral to plasma membrane /// membrane /// integral to membrane","immune response:signal transduction,signaling pathway",4.8653,-1,0,2,0.488,0.2666]
[11,32,"222111_AT","---","CDNA clone IMAGE:4794011","---","---","---","---","---","unknown",12.7979,1,0,-2,-0.7815,0.038]
[11,33,"221510_S_AT","GLS","glutaminase","---","---","glutamine metabolic process /// glutamine catabolic process","glutaminase activity /// glutaminase activity /// hydrolase activity","mitochondrion /// mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",10.3974,1,0,-2,-0.4852,0.2697]
[11,34,"205596_S_AT","SMURF2","SMAD specific E3 ubiquitin protein ligase 2","---","---","protein modification process /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle /// negative regulation of transcription /// regulation of transforming growth factor beta receptor signaling pathway","ubiquitin-protein ligase activity /// ubiquitin-protein ligase activity /// protein binding /// ligase activity","ubiquitin ligase complex /// intracellular /// nucleus /// cytoplasm","dna repair,transcription:signal transduction,signaling pathway",9.7986,1,0,0,-0.614,0.1424]
[11,35,"217851_S_AT","SLMO2","slowmo homolog 2 (Drosophila)","---","---","---","---","---","unknown",14.8447,1,0,-2,-0.4304,0.3351]
[11,36,"212984_AT","ATF2","activating transcription factor 2","Smooth_muscle_contraction /// Smooth_muscle_contraction /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// transcription factor activity /// RNA polymerase II transcription factor activity /// transcription coactivator activity /// protein binding /// protein binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding /// protein dimerization activity","intracellular /// nucleus","dna repair,transcription",10.432,1,1.2947,0,-0.7705,0.0426]
[11,37,"209900_S_AT","SLC16A1","solute carrier family 16, member 1 (monocarboxylic acid transporter 1)","---","---","transport /// organic anion transport /// monocarboxylic acid transport /// mevalonate transport","transporter activity /// protein binding /// monocarboxylic acid transmembrane transporter activity /// mevalonate transmembrane transporter activity /// symporter activity /// secondary active monocarboxylate transmembrane transporter activity","membrane fraction /// membrane /// integral to membrane /// integral to membrane","transport,ion channel",8.9992,1,0,0,-0.3967,0.3783]
[11,38,"212605_S_AT","---","AF034176 Human mRNA (Tripodis and Ragoussis) Homo sapiens cDNA clone ntcon5 contig","---","---","---","---","---","unknown",13.1334,1,0,-2,-0.3952,0.3802]
[11,39,"218886_AT","PAK1IP1","PAK1 interacting protein 1","---","---","negative regulation of signal transduction","---","---","signal transduction,signaling pathway",9.845,1,0,2,-0.1883,0.6859]
[11,40,"221522_AT","ANKRD27","ankyrin repeat domain 27 (VPS9 domain)","---","---","early endosome to late endosome transport","guanyl-nucleotide exchange factor activity /// GTPase activator activity","cytoplasm /// lysosome /// early endosome","transport,ion channel",6.9482,1,0,-2,-0.3782,0.4029]
[11,41,"209674_AT","CRY1","cryptochrome 1 (photolyase-like)","Circadian_Exercise /// Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","DNA repair /// transcription /// regulation of transcription, DNA-dependent /// visual perception /// circadian rhythm /// protein-chromophore linkage /// rhythmic process /// response to stimulus","nucleotide binding /// DNA binding /// DNA photolyase activity /// receptor activity /// G-protein coupled photoreceptor activity /// lyase activity","cytoplasm /// mitochondrion","dna repair,transcription",11.666,1,1.3826,-4,-0.4255,0.3412]
[11,42,"209157_AT","DNAJA2","DnaJ (Hsp40) homolog, subfamily A, member 2","---","---","regulation of progression through cell cycle /// G1 phase of mitotic cell cycle /// protein folding /// positive regulation of cell proliferation","zinc ion binding /// heat shock protein binding /// metal ion binding /// unfolded protein binding","membrane","cell cycle,proliferation",6.7005,1,0.0275,-4,-0.3646,0.4214]
[11,43,"218538_S_AT","MRS2L","MRS2-like, magnesium homeostasis factor (S. cerevisiae)","---","---","transport /// ion transport /// metal ion transport","magnesium ion binding /// metal ion transmembrane transporter activity","mitochondrion /// membrane /// integral to membrane","transport,ion channel",11.777,1,0,0,-0.3106,0.4977]
[11,44,"217826_S_AT","UBE2J1","ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)","---","---","protein modification process /// ubiquitin cycle","ubiquitin-protein ligase activity /// ligase activity /// small conjugating protein ligase activity","endoplasmic reticulum /// membrane /// integral to membrane",null,12.0437,1,1.6813,-2,-0.5227,0.2287]
[11,45,"201780_S_AT","RNF13","ring finger protein 13","---","---","---","protein binding /// zinc ion binding /// metal ion binding","---","unknown",11.024,1,1.3107,4,-0.4434,0.3191]
[11,46,"218247_S_AT","MEX3C","mex-3 homolog C (C. elegans)","---","---","---","RNA binding /// protein binding /// zinc ion binding /// metal ion binding","cytoplasm","unknown",10.8524,1,0,-2,-0.4453,0.3167]
[11,47,"212855_AT","DCUN1D4","DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)","---","---","---","---","nucleus","unknown",12.1278,1,0,-2,-0.6033,0.1515]
[11,48,"220183_S_AT","NUDT6","nudix (nucleoside diphosphate linked moiety X)-type motif 6","---","---","---","growth factor activity /// hydrolase activity","---","unknown",12.0284,1,1.3241,0,-0.6812,0.092]
[11,49,"214662_AT","WDR43","WD repeat domain 43","---","---","---","---","---","unknown",8.8203,1,0,0,0.0017,0.997]
[11,50,"201859_AT","SRGN","serglycin","---","---","ossification /// apoptosis /// apoptosis /// negative regulation of bone mineralization /// mast cell secretory granule organization and biogenesis /// T cell secretory granule organization and biogenesis /// maintenance of protease localization in mast cell secretory granule /// maintenance of granzyme B localization in T cell secretory granule /// negative regulation of cytokine secretion /// protein maturation via proteolysis","protein binding /// protein binding","extracellular space /// Golgi apparatus /// mast cell granule","apoptosis:proteolysis",11.204,1,0,0,-0.8723,0.0104]
[11,51,"201016_AT","EIF1AX","eukaryotic translation initiation factor 1A, X-linked","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation","RNA binding /// translation initiation factor activity /// translation factor activity, nucleic acid binding","eukaryotic translation initiation factor 4F complex",null,11.1835,1,1.2933,0,-0.0336,0.9431]
[11,52,"212245_AT","MCFD2","multiple coagulation factor deficiency 2","---","---","transport /// ER to Golgi vesicle-mediated transport /// protein transport","calcium ion binding","endoplasmic reticulum","transport,ion channel",14.8551,1,0,-2,-0.5126,0.2395]
[11,53,"210432_S_AT","SCN3A","sodium channel, voltage-gated, type III, alpha subunit","---","---","transport /// ion transport /// potassium ion transport /// sodium ion transport /// sodium ion transport","ion channel activity /// voltage-gated ion channel activity /// voltage-gated sodium channel activity /// voltage-gated sodium channel activity /// voltage-gated potassium channel activity /// sodium channel activity /// sodium ion binding","voltage-gated sodium channel complex /// voltage-gated sodium channel complex /// voltage-gated potassium channel complex /// membrane /// integral to membrane","transport,ion channel",12.7583,1,0,-2,-0.9449,0.0013]
[11,54,"202464_S_AT","PFKFB3","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3","---","---","fructose 2,6-bisphosphate metabolic process /// fructose 2,6-bisphosphate metabolic process /// metabolic process","nucleotide binding /// catalytic activity /// 6-phosphofructo-2-kinase activity /// 6-phosphofructo-2-kinase activity /// fructose-2,6-bisphosphate 2-phosphatase activity /// fructose-2,6-bisphosphate 2-phosphatase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// hydrolase activity /// identical protein binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process",25.1307,1,0.1063,0,-0.4252,0.3415]
[11,55,"203140_AT","BCL6","B-cell CLL/lymphoma 6 (zinc finger protein 51)","---","---","protein import into nucleus, translocation /// negative regulation of transcription from RNA polymerase II promoter /// negative regulation of transcription from RNA polymerase II promoter /// cell morphogenesis /// negative regulation of cell-matrix adhesion /// germinal center formation /// regulation of germinal center formation /// negative regulation of T-helper 2 type immune response /// negative regulation of B cell apoptosis /// transcription /// regulation of transcription, DNA-dependent /// response to DNA damage stimulus /// Rho protein signal transduction /// spermatogenesis /// protein localization /// negative regulation of cell proliferation /// actin cytoskeleton organization and biogenesis /// B cell differentiation /// negative regulation of cell growth /// positive regulation of B cell proliferation /// regulation of Rho GTPase activity /// negative regulation of mast cell cytokine production /// negative regulation of Rho protein signal transduction /// T-helper 2 type immune response /// regulation of cell proliferation /// positive regulation of apoptosis /// negative regulation of apoptosis /// regulation of memory T cell differentiation /// negative regulation of cell differentiation /// negative regulation of T-helper 2 cell differentiation /// negative regulation of S phase of mitotic cell cycle /// negative regulation of isotype switching to IgE isotypes /// erythrocyte development /// regulation of inflammatory response /// regulation of immune response /// positive regulation of cell motility","nucleic acid binding /// DNA binding /// chromatin binding /// protein binding /// protein binding /// zinc ion binding /// transcription repressor activity /// transcription repressor activity /// transcription repressor activity /// transcription repressor activity /// sequence-specific DNA binding /// metal ion binding","intracellular /// nucleus /// nucleus /// replication fork","dna repair,transcription:cell growth,differentiation:apoptosis:cell cycle,proliferation:immune response:nuclear matrix,cytoskeleton:signal transduction,signaling pathway",4.8551,1,1.9298,-4,0.0588,0.9004]
[11,56,"201212_AT","LGMN","legumain","---","---","proteolysis","legumain activity /// legumain activity /// cysteine-type endopeptidase activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity","lysosome","proteolysis",21.6703,1,1.3317,-4,-0.4768,0.2793]
[11,57,"208264_S_AT","EIF3J","eukaryotic translation initiation factor 3, subunit J","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// regulation of translational initiation","translation initiation factor activity /// translation initiation factor activity /// protein binding","eukaryotic translation initiation factor 3 complex",null,7.238,1,1.3114,-2,-0.2139,0.6452]
[11,58,"203023_AT","HSPC111","hypothetical protein HSPC111","---","---","---","---","---","unknown",13.0556,1,0,0,-0.1914,0.6809]
[11,59,"204249_S_AT","LMO2","LIM domain only 2 (rhombotin-like 1)","---","---","multicellular organismal development","protein binding /// protein binding /// zinc ion binding /// metal ion binding","---",null,19.1274,1,0,0,-0.597,0.157]
[11,60,"209921_AT","SLC7A11","solute carrier family 7, (cationic amino acid transporter, y+ system) member 11","---","---","protein complex assembly /// transport /// amino acid transport","amino acid transmembrane transporter activity /// cystine:glutamate antiporter activity","membrane /// integral to membrane /// integral to membrane","transport,ion channel",17.3394,-1,0,-2,-0.0084,0.9858]
[11,61,"213562_S_AT","SQLE","squalene epoxidase","Cholesterol_Biosynthesis /// Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","electron transport /// metabolic process /// sterol biosynthetic process","squalene monooxygenase activity /// squalene monooxygenase activity /// oxidoreductase activity","endoplasmic reticulum /// microsome /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",15.1233,1,0,0,0.2293,0.6209]
[]
[null,null,12]
[12,1,"214035_X_AT","LOC399491","LOC399491 protein","---","---","neuropeptide signaling pathway","---","membrane /// integral to membrane","signal transduction,signaling pathway",0.5339,1,0.5008,0,0.4084,0.3631]
[12,2,"212372_AT","MYH10","myosin, heavy chain 10, non-muscle","---","---","regulation of cell shape","microfilament motor activity /// nucleotide binding /// motor activity /// actin binding /// actin binding /// protein binding /// protein binding /// calmodulin binding /// ATP binding /// ATP binding /// actin filament binding","stress fiber /// cytoplasm /// cell cortex /// myosin complex /// myosin complex /// midbody /// cleavage furrow",null,0.4813,1,1.8042,2,-0.1324,0.7771]
[12,3,"208159_X_AT","DDX11","DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)","---","---","mitotic sister chromatid segregation /// regulation of progression through cell cycle /// S phase of mitotic cell cycle /// G2/M transition of mitotic cell cycle /// nucleobase, nucleoside, nucleotide and nucleic acid metabolic process /// cell cycle /// positive regulation of cell proliferation","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA helicase activity /// RNA binding /// ATP-dependent DNA helicase activity /// helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides","nucleus /// nucleolus","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",0.3555,1,1.2431,2,0.4748,0.2817]
[12,4,"211454_X_AT","FKSG49","FKSG49","---","---","---","---","---","unknown",0.3682,1,1.1268,0,0.2405,0.6035]
[12,5,"204538_X_AT","LOC339047 /// LOC642778 /// LOC642799 /// NPIP","nuclear pore complex interacting protein /// hypothetical protein LOC339047 /// similar to nuclear pore complex interacting protein","---","---","protein targeting /// transport /// neuropeptide signaling pathway /// protein transport /// mRNA transport","---","nuclear pore /// membrane /// integral to membrane","transport,ion channel:signal transduction,signaling pathway",0.3007,1,1.384,4,0.4004,0.3735]
[12,6,"210686_X_AT","SLC25A16","solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16","---","---","transport /// transport","binding /// solute:solute antiporter activity","mitochondrion /// mitochondrial inner membrane /// mitochondrial inner membrane /// membrane /// integral to membrane","transport,ion channel",0.2204,1,0.9507,2,0.0611,0.8965]
[12,7,"201721_S_AT","LAPTM5","lysosomal associated multispanning membrane protein 5","---","---","transport","---","lysosome /// lysosome /// integral to plasma membrane /// membrane /// integral to membrane","transport,ion channel",0.3121,1,1.5452,2,-0.0289,0.951]
[12,8,"208796_S_AT","CCNG1","cyclin G1","---","---","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// cell cycle /// mitosis /// cell division","---","---","cell cycle,proliferation",0.5079,1,0.0008,6,0.4262,0.3404]
[12,9,"210230_AT","---","CDNA: FLJ23438 fis, clone HRC13275","---","---","---","---","---","unknown",0.7983,1,0,2,-0.0919,0.8446]
[12,10,"218403_AT","TRIAP1","TP53 regulated inhibitor of apoptosis 1","---","---","apoptosis /// anti-apoptosis /// DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest /// DNA damage response, signal transduction by p53 class mediator","protein binding /// caspase inhibitor activity","cytoplasm /// mitochondrion","apoptosis:cell cycle,proliferation:signal transduction,signaling pathway",0.35,1,0,2,0.7745,0.0409]
[12,11,"205692_S_AT","CD38","CD38 molecule","---","---","generation of precursor metabolites and energy /// signal transduction /// induction of apoptosis by extracellular signals","catalytic activity /// NAD+ nucleosidase activity /// receptor activity /// hydrolase activity /// hydrolase activity, acting on glycosyl bonds /// phosphorus-oxygen lyase activity","membrane fraction /// membrane fraction /// plasma membrane /// membrane /// integral to membrane","apoptosis:signal transduction,signaling pathway",1.0689,1,0.0006,2,0.382,0.3978]
[12,12,"203409_AT","DDB2","damage-specific DNA binding protein 2, 48kDa","---","---","DNA repair /// DNA repair /// nucleotide-excision repair /// response to DNA damage stimulus","DNA binding /// DNA binding /// damaged DNA binding /// protein binding","---","dna repair,transcription",0.6436,1,0,6,0.5886,0.1645]
[]
[null,null,13]
[13,1,"214403_X_AT","SPDEF","SAM pointed domain containing ets transcription factor","---","---","transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development","DNA binding /// transcription factor activity /// protein binding /// sequence-specific DNA binding","nucleus","dna repair,transcription",10.1268,-1,0,1,0.1642,0.7251]
[13,2,"215700_X_AT","CPNE6","copine VI (neuronal)","---","---","lipid metabolic process /// synaptic transmission /// nervous system development /// vesicle-mediated transport","phosphatidylserine binding /// transporter activity /// calcium ion binding","membrane fraction /// axon /// dendrite","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",6.3566,1,1.7569,0,0.3807,0.3995]
[13,3,"210284_S_AT","MAP3K7IP2","mitogen-activated protein kinase kinase kinase 7 interacting protein 2","Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","positive regulation of I-kappaB kinase/NF-kappaB cascade /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// signal transducer activity /// zinc ion binding /// metal ion binding","intracellular /// cytoplasm /// membrane",null,2.992,1,0,3,0.5652,0.1861]
[13,4,"204321_AT","NEO1","neogenin homolog 1 (chicken)","---","---","protein amino acid phosphorylation /// cell motility /// cell adhesion /// cell adhesion /// cell-cell signaling /// multicellular organismal development","vascular endothelial growth factor receptor activity /// protein binding /// ATP binding","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","cell adhesion",1.6711,1,0,2,0.3467,0.4462]
[13,5,"210605_S_AT","MFGE8","milk fat globule-EGF factor 8 protein","---","---","cell adhesion /// cell adhesion /// single fertilization","protein binding","lipid particle /// membrane","cell adhesion",6.4183,1,0.5209,1,0.3083,0.5012]
[13,6,"221718_S_AT","AKAP13","A kinase (PRKA) anchor protein 13","---","---","intracellular signaling cascade /// regulation of Rho protein signal transduction","signal transducer activity /// receptor activity /// guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity /// calcium ion binding /// zinc ion binding /// diacylglycerol binding /// metal ion binding","intracellular /// membrane fraction /// cytoplasm /// membrane","signal transduction,signaling pathway",2.0252,1,0,1,-0.5832,0.1693]
[13,7,"201998_AT","ST6GAL1","ST6 beta-galactosamide alpha-2,6-sialyltranferase 1","---","---","protein modification process /// protein amino acid glycosylation /// humoral immune response /// oligosaccharide metabolic process","beta-galactoside alpha-2,6-sialyltransferase activity /// beta-galactoside alpha-2,6-sialyltransferase activity /// sialyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups","membrane /// integral to membrane /// integral to Golgi membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:immune response",7.3603,1,0,2,-0.1385,0.7671]
[13,8,"208390_S_AT","GLP1R","glucagon-like peptide 1 receptor","GPCRDB_Class_B_Secretin-like","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Class_B_Secretin-like/Hs_GPCRDB_Class_B_Secretin-like.htm","response to stress /// signal transduction /// G-protein coupled receptor protein signaling pathway /// adenylate cyclase activation /// elevation of cytosolic calcium ion concentration /// learning and/or memory /// regulation of heart contraction /// cAMP-mediated signaling","signal transducer activity /// receptor activity /// transmembrane receptor activity /// G-protein coupled receptor activity /// glucagon receptor activity /// peptide receptor activity, G-protein coupled","plasma membrane /// membrane /// integral to membrane /// integral to membrane","signal transduction,signaling pathway",7.3712,1,0,1,0.2548,0.5813]
[13,9,"214894_X_AT","MACF1","microtubule-actin crosslinking factor 1","---","---","mesoderm formation /// carbohydrate metabolic process /// posttranslational protein targeting to membrane /// cell motility /// cell cycle arrest /// establishment and/or maintenance of cell polarity /// Wnt receptor signaling pathway","actin binding /// actin binding /// hydrolase activity, hydrolyzing O-glycosyl compounds /// calcium ion binding /// calcium ion binding /// protein binding /// protein binding /// microtubule binding /// microtubule binding /// actin filament binding","cytoplasm /// cytoplasm /// cytoplasm /// cytoskeleton /// cytoskeleton /// actin cytoskeleton /// microtubule cytoskeleton","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",3.8757,1,0,-1,0.2292,0.621]
[13,10,"213441_X_AT","SPDEF","SAM pointed domain containing ets transcription factor","---","---","transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development","DNA binding /// transcription factor activity /// protein binding /// sequence-specific DNA binding","nucleus","dna repair,transcription",5.7489,1,1.3226,1,0.3621,0.4248]
[13,11,"217723_X_AT","---","---","---","---","---","---","---","unknown",8.4838,1,1.2134,1,0.2728,0.5539]
[13,12,"216210_X_AT","TRIOBP","TRIO and F-actin binding protein","---","---","sensory perception of sound /// actin modification /// barbed-end actin filament capping","actin binding /// GTP-Rho binding /// myosin II binding","cytoplasm /// cytoskeleton /// actin cytoskeleton",null,3.7212,1,1.6531,3,0.0559,0.9052]
[13,13,"208982_AT","PECAM1","platelet/endothelial cell adhesion molecule (CD31 antigen)","---","---","cell motility /// cell adhesion /// signal transduction /// cell recognition","protein binding","plasma membrane /// intercellular junction /// membrane /// integral to membrane","cell adhesion:signal transduction,signaling pathway",5.3085,1,0,-1,-0.6045,0.1505]
[13,14,"202039_AT","MYO18A /// TIAF1","TGFB1-induced anti-apoptotic factor 1 /// myosin XVIIIA","---","---","DNA metabolic process /// apoptosis /// anti-apoptosis /// anti-apoptosis /// I-kappaB kinase/NF-kappaB cascade","nucleotide binding /// DNA binding /// motor activity /// receptor activity /// protein binding /// ATP binding /// DNA-dependent ATPase activity","nucleus /// cytoplasm /// myosin complex","biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis",5.5375,-1,1.6784,1,-0.7398,0.0573]
[13,15,"210582_S_AT","LIMK2","LIM domain kinase 2","---","---","protein amino acid phosphorylation /// phosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// metal ion binding","nucleus /// cytoplasm /// cytoplasm",null,2.2208,1,0.4412,3,0.4873,0.2674]
[13,16,"203734_AT","FOXJ2","forkhead box J2","---","---","transcription /// regulation of transcription, DNA-dependent","DNA binding /// transcription factor activity /// sequence-specific DNA binding","nucleus","dna repair,transcription",5.5249,1,0,3,0.285,0.5355]
[13,17,"213827_AT","SNX26","sorting nexin 26","---","---","transport /// signal transduction /// protein transport","GTPase activator activity /// protein binding","intracellular","transport,ion channel:signal transduction,signaling pathway",5.8602,1,1.579,1,-0.0331,0.9438]
[13,18,"201302_AT","ANXA4","annexin A4","Prostaglandin_synthesis_regulation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Prostaglandin_synthesis_regulation/Hs_Prostaglandin_synthesis_regulation.htm","anti-apoptosis /// signal transduction /// negative regulation of coagulation","phospholipase inhibitor activity /// calcium ion binding /// calcium ion binding /// calcium-dependent phospholipid binding /// calcium-dependent phospholipid binding","cytoplasm","apoptosis:signal transduction,signaling pathway",1.8289,-1,0,3,0.0795,0.8655]
[13,19,"201294_S_AT","WSB1","WD repeat and SOCS box-containing 1","---","---","intracellular signaling cascade","kinase activity","intracellular",null,6.4287,-1,0,1,0.2382,0.607]
[13,20,"205998_X_AT","CYP3A4","cytochrome P450, family 3, subfamily A, polypeptide 4","Irinotecan_pathway_PharmGKB /// Irinotecan_pathway_PharmGKB /// Irinotecan_pathway_PharmGKB","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Irinotecan_pathway_PharmGKB/Hs_Irinotecan_pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Irinotecan_pathway_PharmGKB/Hs_Irinotecan_pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Irinotecan_pathway_PharmGKB/Hs_Irinotecan_pathway_PharmGKB.htm","electron transport /// lipid metabolic process /// xenobiotic metabolic process","monooxygenase activity /// monooxygenase activity /// monooxygenase activity /// monooxygenase activity /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen /// oxygen binding /// heme binding /// metal ion binding /// unspecific monooxygenase activity /// quinine 3-monooxygenase activity /// testosterone 6-beta-hydroxylase activity","membrane fraction /// endoplasmic reticulum /// microsome /// microsome /// cell surface /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",7.0352,1,1.276,3,0.1965,0.6728]
[13,21,"207035_AT","SLC30A3","solute carrier family 30 (zinc transporter), member 3","---","---","transport /// transport /// ion transport /// cation transport /// zinc ion transport","zinc ion binding /// cation transmembrane transporter activity /// zinc transporting ATPase activity","membrane fraction /// endosome /// integral to plasma membrane /// synaptic vesicle /// membrane /// integral to membrane /// cell junction /// cytoplasmic vesicle /// synapse","transport,ion channel",4.3869,1,0,0,0.0426,0.9277]
[13,22,"209002_S_AT","CALCOCO1","calcium binding and coiled-coil domain 1","---","---","transcription /// signal transduction /// steroid hormone receptor signaling pathway","transcription coactivator activity /// protein binding","nucleus","dna repair,transcription:signal transduction,signaling pathway",7.7011,1,0,0,0.1983,0.6699]
[13,23,"206764_X_AT","MPPE1","metallophosphoesterase 1","---","---","---","hydrolase activity","---","unknown",7.9156,1,0,0,0.2834,0.538]
[13,24,"202481_AT","DHRS3","dehydrogenase/reductase (SDR family) member 3","---","---","visual perception /// metabolic process /// retinol metabolic process","nucleotide binding /// electron carrier activity /// oxidoreductase activity","membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",13.5993,-1,0,0,0.758,0.0483]
[13,25,"201301_S_AT","ANXA4","annexin A4","Prostaglandin_synthesis_regulation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Prostaglandin_synthesis_regulation/Hs_Prostaglandin_synthesis_regulation.htm","anti-apoptosis /// signal transduction /// negative regulation of coagulation","phospholipase inhibitor activity /// calcium ion binding /// calcium ion binding /// calcium-dependent phospholipid binding /// calcium-dependent phospholipid binding","cytoplasm","apoptosis:signal transduction,signaling pathway",2.7771,1,0,0,0.0955,0.8386]
[13,26,"215492_X_AT","PTCRA","pre T-cell antigen receptor alpha","---","---","---","receptor activity","---","unknown",2.6465,1,1.3202,0,0.1163,0.804]
[13,27,"201613_S_AT","AP1G2","adaptor-related protein complex 1, gamma 2 subunit","---","---","protein complex assembly /// transport /// intracellular protein transport /// endocytosis /// protein transport /// vesicle-mediated transport /// vesicle-mediated transport","binding /// protein binding /// protein binding /// protein binding /// protein transporter activity","Golgi apparatus /// Golgi-associated vesicle /// Golgi-associated vesicle /// membrane /// membrane /// membrane /// integral to membrane /// membrane coat /// AP-1 adaptor complex /// clathrin adaptor complex /// transport vesicle /// transport vesicle /// cytoplasmic vesicle","transport,ion channel",5.269,-1,1.0684,0,0.1498,0.7486]
[13,28,"201749_AT","ECE1","Endothelin converting enzyme 1","---","---","proteolysis /// cell-cell signaling","metalloendopeptidase activity /// neprilysin activity /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// endothelin-converting enzyme 1 activity /// hydrolase activity /// metal ion binding","membrane fraction /// membrane /// integral to membrane /// integral to membrane","proteolysis",4.5392,-1,0,0,0.8956,0.0064]
[13,29,"209166_S_AT","MAN2B1","mannosidase, alpha, class 2B, member 1","---","---","carbohydrate metabolic process /// mannose metabolic process /// protein modification process /// protein deglycosylation /// learning and/or memory /// metabolic process","catalytic activity /// alpha-mannosidase activity /// alpha-mannosidase activity /// zinc ion binding /// mannosidase activity /// hydrolase activity /// hydrolase activity, acting on glycosyl bonds /// cation binding /// metal ion binding","lysosome","biosynthesis,metabolism,metabolic process,biosynthetic process",0.978,1,0.0004,0,0.703,0.0781]
[13,30,"207643_S_AT","TNFRSF1A","tumor necrosis factor receptor superfamily, member 1A","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG /// Inflammatory_Response_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Inflammatory_Response_Pathway/Hs_Inflammatory_Response_Pathway.htm","prostaglandin metabolic process /// apoptosis /// inflammatory response /// signal transduction /// cytokine and chemokine mediated signaling pathway /// positive regulation of I-kappaB kinase/NF-kappaB cascade /// positive regulation of transcription from RNA polymerase II promoter /// positive regulation of inflammatory response","signal transducer activity /// receptor activity /// tumor necrosis factor receptor activity /// protein binding /// protein binding","extracellular region /// extracellular region /// integral to plasma membrane /// membrane /// integral to membrane","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:signal transduction,signaling pathway",6.6515,-1,0,0,-0.6963,0.0822]
[13,31,"214395_X_AT","---","CDNA clone IMAGE:4838699","---","---","---","---","---","unknown",6.64,1,0,0,0.4012,0.3724]
[13,32,"59697_AT","RAB15","RAB15, member RAS onocogene family","---","---","transport /// small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTP binding","membrane","transport,ion channel:signal transduction,signaling pathway",6.247,1,0,0,-0.0242,0.959]
[13,33,"209698_AT","CCHCR1","coiled-coil alpha-helical rod protein 1","---","---","protein export from nucleus /// multicellular organismal development /// cell differentiation","protein binding","nucleus /// cytoplasm","cell growth,differentiation",1.4872,1,1.0168,0,0.2605,0.5726]
[13,34,"1007_S_AT","DDR1","discoidin domain receptor family, member 1","---","---","protein amino acid phosphorylation /// cell adhesion /// cell adhesion /// transmembrane receptor protein tyrosine kinase signaling pathway","nucleotide binding /// protein kinase activity /// protein-tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// receptor activity /// ATP binding /// kinase activity /// transferase activity","integral to plasma membrane /// membrane /// integral to membrane","cell adhesion:signal transduction,signaling pathway",10.691,1,0,0,0.3304,0.4692]
[13,35,"209147_S_AT","PPAP2A","phosphatidic acid phosphatase type 2A","---","---","lipid metabolic process /// protein kinase C activation /// negative regulation of cell proliferation /// germ cell migration /// regulation of lipid metabolic process /// steroid hormone receptor signaling pathway /// androgen receptor signaling pathway /// phospholipid dephosphorylation","phosphatidate phosphatase activity /// phosphatidate phosphatase activity /// phosphatidate phosphatase activity /// hydrolase activity","membrane fraction /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",7.1699,1,0,0,0.7749,0.0407]
[13,36,"213727_X_AT","MPPE1","metallophosphoesterase 1","---","---","---","hydrolase activity","---","unknown",3.5961,1,1.4858,0,-0.0979,0.8346]
[13,37,"203805_S_AT","FANCA","Fanconi anemia, complementation group A","---","---","DNA repair /// DNA repair /// protein complex assembly /// response to DNA damage stimulus","protein binding","nucleus /// cytoplasm /// cytoplasm","dna repair,transcription",6.2142,1,0,0,0.5,0.2532]
[13,38,"204882_AT","ARHGAP25","Rho GTPase activating protein 25","---","---","signal transduction","GTPase activator activity","intracellular","signal transduction,signaling pathway",3.9957,1,0.4199,0,-0.2842,0.5368]
[13,39,"210749_X_AT","DDR1","discoidin domain receptor family, member 1","---","---","protein amino acid phosphorylation /// cell adhesion /// cell adhesion /// transmembrane receptor protein tyrosine kinase signaling pathway","nucleotide binding /// protein kinase activity /// protein-tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// receptor activity /// ATP binding /// kinase activity /// transferase activity","integral to plasma membrane /// membrane /// integral to membrane","cell adhesion:signal transduction,signaling pathway",1.6024,1,0,0,0.6068,0.1486]
[13,40,"209584_X_AT","APOBEC3C","apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C","---","---","---","RNA binding /// protein binding /// zinc ion binding /// hydrolase activity /// hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines /// metal ion binding","---","unknown",1.1158,-1,0,0,0.089,0.8494]
[13,41,"217743_S_AT","TMEM30A","transmembrane protein 30A","---","---","---","---","membrane /// integral to membrane","unknown",9.0518,1,0,0,0.5941,0.1596]
[13,42,"218181_S_AT","MAP4K4","mitogen-activated protein kinase kinase kinase kinase 4","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// response to stress /// protein kinase cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// small GTPase regulator activity /// ATP binding /// ATP binding /// kinase activity /// transferase activity","---",null,10.2867,-1,0,0,0.4462,0.3156]
[13,43,"204060_S_AT","PRKX /// PRKY","protein kinase, X-linked /// protein kinase, Y-linked","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// cAMP-dependent protein kinase activity /// protein-tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity","---",null,11.7103,-1,0,0,0.9003,0.0057]
[13,44,"38149_AT","ARHGAP25","Rho GTPase activating protein 25","---","---","signal transduction","GTPase activator activity","intracellular","signal transduction,signaling pathway",3.1883,1,0.5562,0,-0.2422,0.6008]
[13,45,"39248_AT","AQP3","aquaporin 3 (Gill blood group)","---","---","transport /// transport /// excretion","transporter activity /// transporter activity","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane","transport,ion channel",5.8143,-1,1.4572,0,0.0521,0.9117]
[13,46,"204566_AT","PPM1D","protein phosphatase 1D magnesium-dependent, delta isoform","---","---","regulation of progression through cell cycle /// G2/M transition of mitotic cell cycle /// protein amino acid dephosphorylation /// protein amino acid dephosphorylation /// cell cycle /// negative regulation of cell proliferation /// response to radiation /// response to bacterium","magnesium ion binding /// catalytic activity /// phosphoprotein phosphatase activity /// protein serine/threonine phosphatase activity /// protein phosphatase type 2C activity /// protein phosphatase type 2C activity /// hydrolase activity /// manganese ion binding /// metal ion binding","nucleus /// protein serine/threonine phosphatase complex","cell cycle,proliferation",7.6251,-1,0,0,0.6856,0.0891]
[13,47,"218634_AT","PHLDA3","pleckstrin homology-like domain, family A, member 3","---","---","anatomical structure morphogenesis","protein binding","---",null,13.2033,1,0,0,0.7454,0.0545]
[13,48,"201835_S_AT","PRKAB1","protein kinase, AMP-activated, beta 1 non-catalytic subunit","Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","carbohydrate metabolic process /// fatty acid biosynthetic process /// signal transduction /// lipid biosynthetic process","hydrolase activity, hydrolyzing O-glycosyl compounds /// protein binding","nucleus","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway",10.4713,1,0.0006,0,0.7886,0.0351]
[13,49,"210241_S_AT","TP53AP1","TP53 activated protein 1","---","---","response to stress /// response to DNA damage stimulus","signal transducer activity","nucleus",null,8.2488,-1,1.4332,0,0.2102,0.651]
[13,50,"210886_X_AT","TP53AP1","TP53 activated protein 1","---","---","response to stress /// response to DNA damage stimulus","signal transducer activity","nucleus",null,6.5326,1,1.8345,0,0.2312,0.6179]
[13,51,"212062_AT","ATP9A","ATPase, Class II, type 9A","---","---","transport /// cation transport /// metabolic process /// phospholipid transport","nucleotide binding /// magnesium ion binding /// catalytic activity /// phospholipid-translocating ATPase activity /// ATP binding /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// metal ion binding","membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",13.7287,1,0,0,0.2146,0.6441]
[13,52,"219815_AT","GAL3ST4","galactose-3-O-sulfotransferase 4","---","---","sulfur metabolic process /// cell-cell signaling /// biosynthetic process /// glycoprotein metabolic process /// oligosaccharide metabolic process /// proteoglycan biosynthetic process","galactosylceramide sulfotransferase activity /// transferase activity /// GPI anchor binding /// 3'-phosphoadenosine 5'-phosphosulfate binding /// galactose 3-O-sulfotransferase activity /// proteoglycan sulfotransferase activity","proteinaceous extracellular matrix /// membrane fraction /// endoplasmic reticulum /// Golgi apparatus /// membrane /// integral to membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",6.2304,1,0,0,0.5115,0.2406]
[]
[null,null,14]
[14,1,"208812_X_AT","HLA-C /// LOC732037","major histocompatibility complex, class I, C /// similar to major histocompatibility complex, class I, C","Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","ciliary or flagellar motility /// antigen processing and presentation of peptide antigen via MHC class I /// immune response /// immune response /// antigen processing and presentation","microtubule motor activity /// MHC class I receptor activity /// MHC class II receptor activity","axonemal dynein complex /// integral to plasma membrane /// membrane /// membrane /// integral to membrane /// MHC class I protein complex","immune response",0.1216,1,0,2,0.6533,0.1116]
[14,2,"201577_AT","NME1","non-metastatic cells 1, protein (NM23A) expressed in","Nucleotide_Metabolism","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Nucleotide_Metabolism/Hs_Nucleotide_Metabolism.htm","GTP biosynthetic process /// UTP biosynthetic process /// CTP biosynthetic process /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// rRNA processing /// cell cycle /// cell adhesion /// negative regulation of cell proliferation /// nucleotide metabolic process /// nucleoside triphosphate biosynthetic process /// pyrimidine ribonucleoside triphosphate biosynthetic process /// regulation of apoptosis /// negative regulation of apoptosis /// positive regulation of keratinocyte differentiation /// regulation of epidermis development /// negative regulation of progression through cell cycle /// positive regulation of epithelial cell proliferation","nucleotide binding /// magnesium ion binding /// magnesium ion binding /// DNA binding /// DNA binding /// transcription factor activity /// deoxyribonuclease activity /// nucleoside diphosphate kinase activity /// nucleoside diphosphate kinase activity /// nucleoside diphosphate kinase activity /// protein binding /// protein binding /// ATP binding /// ATP binding /// kinase activity /// transferase activity /// snoRNA binding /// metal ion binding","ruffle /// nucleus /// nucleus /// nucleus /// small nucleolar ribonucleoprotein complex /// cytoplasm /// cytoplasm /// lamellipodium","dna repair,transcription:cell growth,differentiation:cell adhesion:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:cell cycle,proliferation",0.3645,1,1.6849,2,0.253,0.5841]
[14,3,"205347_S_AT","TMSL8","thymosin-like 8","---","---","cytoskeleton organization and biogenesis","actin binding","cytoplasm /// cytoplasm /// cytoskeleton","nuclear matrix,cytoskeleton",0.0828,1,1.8229,3,-0.1556,0.7391]
[14,4,"201416_AT","SOX4","SRY (sex determining region Y)-box 4","---","---","transcription /// regulation of transcription, DNA-dependent /// exocrine pancreas development","DNA binding /// transcription factor activity","nucleus","dna repair,transcription",0.4904,1,0,3,-0.1002,0.8307]
[14,5,"208998_AT","UCP2","uncoupling protein 2 (mitochondrial, proton carrier)","Electron_Transport_Chain","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Electron_Transport_Chain/Hs_Electron_Transport_Chain.htm","transport /// transport /// mitochondrial transport /// proton transport","transporter activity /// binding","membrane fraction /// mitochondrion /// mitochondrial inner membrane /// mitochondrial inner membrane /// membrane /// integral to membrane","transport,ion channel",0.4023,1,0,4,0.4023,0.371]
[14,6,"221501_X_AT","LOC339047","hypothetical protein LOC339047","---","---","neuropeptide signaling pathway","---","membrane /// integral to membrane","signal transduction,signaling pathway",0.2973,1,0.5658,5,0.4591,0.3001]
[14,7,"206323_X_AT","OPHN1","oligophrenin 1","---","---","substrate-bound cell migration, cell extension /// signal transduction /// signal transduction /// nervous system development /// axon guidance /// actin cytoskeleton organization and biogenesis","actin binding /// GTPase activator activity /// Rho GTPase activator activity","intracellular /// actin cytoskeleton","nuclear matrix,cytoskeleton:signal transduction,signaling pathway",0.8791,1,1.8408,2,0.3604,0.4271]
[14,8,"204026_S_AT","ZWINT","ZW10 interactor","---","---","mitotic sister chromatid segregation /// cell cycle /// cell cycle /// spindle organization and biogenesis /// mitosis /// mitotic cell cycle checkpoint /// phosphoinositide-mediated signaling /// cell division /// establishment of cellular localization","protein binding /// protein N-terminus binding","chromosome, pericentric region /// kinetochore /// nucleus /// cytoplasm /// cytoplasm","cell cycle,proliferation",0.2087,1,1.5638,3,-0.0447,0.9242]
[14,9,"209140_X_AT","HLA-B","major histocompatibility complex, class I, B","Proteasome_Degradation /// Proteasome_Degradation /// Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","antigen processing and presentation of peptide antigen via MHC class I /// defense response /// immune response /// immune response /// antigen processing and presentation","protein binding /// MHC class I receptor activity","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane /// MHC class I protein complex","immune response",0.1956,1,0.1925,3,0.7715,0.0422]
[14,10,"211600_AT","---","---","Electron_Transport_Chain","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Electron_Transport_Chain/Hs_Electron_Transport_Chain.htm","mitochondrial electron transport, NADH to ubiquinone /// ATP synthesis coupled electron transport","NADH dehydrogenase (ubiquinone) activity /// NADH dehydrogenase (ubiquinone) activity /// oxidoreductase activity","mitochondrion /// mitochondrial respiratory chain complex I /// membrane /// integral to membrane","transport,ion channel",0.4114,1,0,0,0.0184,0.9687]
[14,11,"213060_S_AT","CHI3L2","chitinase 3-like 2","---","---","carbohydrate metabolic process /// chitin catabolic process","catalytic activity /// hydrolase activity, hydrolyzing O-glycosyl compounds /// chitinase activity /// hydrolase activity /// cation binding","extracellular space","biosynthesis,metabolism,metabolic process,biosynthetic process",0.2785,1,0.7046,3,0.0297,0.9496]
[14,12,"221081_S_AT","DENND2D","DENN/MADD domain containing 2D","---","---","---","---","---","unknown",0.3848,1,0.0002,-1,0.3352,0.4623]
[14,13,"218007_S_AT","RPS27L","ribosomal protein S27-like","---","---","translation","structural constituent of ribosome /// zinc ion binding /// metal ion binding","intracellular /// ribosome /// ribonucleoprotein complex",null,0.4474,1,0.0004,-1,0.3573,0.4314]
[]
[null,null,15]
[15,1,"211015_S_AT","HSPA4","heat shock 70kDa protein 4","---","---","response to unfolded protein","nucleotide binding /// ATP binding /// ATP binding","cytoplasm /// cytoplasm",null,5.3683,1,0,3,-0.1145,0.8069]
[15,2,"212502_AT","C10orf22","chromosome 10 open reading frame 22","---","---","---","---","---","unknown",5.4319,-1,0,4,-0.3461,0.447]
[15,3,"202295_S_AT","CTSH","cathepsin H","---","---","proteolysis /// proteolysis","cysteine-type endopeptidase activity /// cathepsin H activity /// cathepsin H activity /// peptidase activity /// cysteine-type peptidase activity /// cysteine-type peptidase activity /// hydrolase activity","lysosome","proteolysis",5.7337,-1,0,3,-0.9648,0.0004]
[15,4,"203704_S_AT","---","---","---","---","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// Ras protein signal transduction /// multicellular organismal development","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription:signal transduction,signaling pathway",5.8324,-1,0,4,-0.8261,0.022]
[15,5,"201830_S_AT","NET1","neuroepithelial cell transforming gene 1","---","---","regulation of cell growth /// signal transduction /// regulation of Rho protein signal transduction","guanyl-nucleotide exchange factor activity /// guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity","intracellular /// cytoplasm","cell growth,differentiation:signal transduction,signaling pathway",13.7555,1,0,5,-0.8283,0.0213]
[15,6,"212802_S_AT","GAPVD1","GTPase activating protein and VPS9 domains 1","---","---","regulation of small GTPase mediated signal transduction","GTPase activator activity","intracellular","signal transduction,signaling pathway",7.6065,1,0,4,-0.6252,0.1333]
[15,7,"212293_AT","HIPK1","homeodomain interacting protein kinase 1","---","---","transcription /// regulation of transcription, DNA-dependent /// protein amino acid phosphorylation","nucleotide binding /// DNA binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","cytoplasm","dna repair,transcription",5.964,-1,0,5,-0.7544,0.05]
[15,8,"208447_S_AT","PRPS1","phosphoribosyl pyrophosphate synthetase 1","---","---","purine base metabolic process /// nervous system development /// nucleoside metabolic process /// ribonucleoside monophosphate biosynthetic process /// nucleotide biosynthetic process /// cellular biosynthetic process","magnesium ion binding /// ribose phosphate diphosphokinase activity /// ribose phosphate diphosphokinase activity /// kinase activity /// transferase activity /// lipoate-protein ligase B activity /// metal ion binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process",6.4166,1,0,3,0.0982,0.834]
[15,9,"203988_S_AT","FUT8","fucosyltransferase 8 (alpha (1,6) fucosyltransferase)","---","---","in utero embryonic development /// protein amino acid N-linked glycosylation /// N-glycan processing /// oligosaccharide biosynthetic process /// L-fucose catabolic process","glycoprotein 6-alpha-L-fucosyltransferase activity /// glycoprotein 6-alpha-L-fucosyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups","Golgi apparatus /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",7.8703,-1,0,4,-0.9389,0.0017]
[15,10,"217758_S_AT","TM9SF3","transmembrane 9 superfamily member 3","---","---","---","binding","membrane /// integral to membrane","unknown",4.4798,-1,1.5008,-4,-0.3342,0.4638]
[15,11,"213998_S_AT","DDX17","DEAD (Asp-Glu-Ala-Asp) box polypeptide 17","---","---","RNA processing","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// RNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// RNA-dependent ATPase activity /// hydrolase activity","nucleus",null,11.8759,-1,0,3,-0.664,0.1038]
[15,12,"207785_S_AT","RBPJ","recombination signal binding protein for immunoglobulin kappa J region","---","---","DNA recombination /// transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// Notch signaling pathway /// negative regulation of transcription, DNA-dependent","recombinase activity /// DNA binding /// DNA binding /// transcription factor activity /// RNA polymerase II transcription factor activity /// protein binding","nucleus /// nucleolus","dna repair,transcription:signal transduction,signaling pathway",9.2052,1,0.9713,-6,0.1234,0.7922]
[15,13,"208857_S_AT","PCMT1","protein-L-isoaspartate (D-aspartate) O-methyltransferase","---","---","protein modification process /// protein amino acid methylation","protein-L-isoaspartate (D-aspartate) O-methyltransferase activity /// protein binding /// methyltransferase activity /// transferase activity /// identical protein binding","cytoplasm /// endoplasmic reticulum",null,8.014,-1,0,-4,-0.4215,0.3463]
[15,14,"218438_S_AT","MED28","mediator complex subunit 28","---","---","transcription /// regulation of transcription, DNA-dependent","actin binding /// protein binding","cytoplasm /// cytoskeleton /// membrane","dna repair,transcription",7.7789,1,0.0009,-1,-0.3747,0.4076]
[15,15,"212030_AT","RBM25","RNA binding motif protein 25","---","---","nuclear mRNA splicing, via spliceosome /// mRNA processing","nucleotide binding /// nucleic acid binding /// mRNA binding","ribonucleoprotein complex",null,5.8318,-1,0,4,-0.4311,0.3343]
[15,16,"209130_AT","SNAP23","synaptosomal-associated protein, 23kDa","---","---","transport /// post-Golgi vesicle-mediated transport /// vesicle targeting /// membrane fusion /// protein transport","protein binding","plasma membrane /// membrane /// synaptosome /// cell junction /// synapse","transport,ion channel",7.9185,-1,0,-6,-0.7166,0.07]
[15,17,"204226_AT","STAU2","staufen, RNA binding protein, homolog 2 (Drosophila)","---","---","transport","RNA binding /// double-stranded RNA binding /// double-stranded RNA binding","intracellular /// cytoplasm /// endoplasmic reticulum /// microtubule","transport,ion channel",4.9042,-1,0,-6,-0.886,0.0079]
[15,18,"220990_S_AT","MIRN21 /// TMEM49","transmembrane protein 49 /// microRNA 21","---","---","---","---","endoplasmic reticulum /// endoplasmic reticulum /// membrane /// integral to membrane","unknown",9.9201,1,0,-6,-0.0613,0.8962]
[15,19,"201772_AT","AZIN1","antizyme inhibitor 1","Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","polyamine biosynthetic process","catalytic activity /// enzyme inhibitor activity /// protein binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process",7.1759,-1,0,-1,-0.7987,0.0312]
[15,20,"201688_S_AT","TPD52","tumor protein D52","---","---","anatomical structure morphogenesis /// B cell differentiation /// secretion","calcium ion binding /// protein binding /// identical protein binding /// protein homodimerization activity /// protein heterodimerization activity","cytoplasm /// endoplasmic reticulum /// perinuclear region of cytoplasm","cell growth,differentiation",5.9402,1,1.4386,-6,-0.4457,0.3162]
[15,21,"218150_AT","ARL5A","ADP-ribosylation factor-like 5A","---","---","small GTPase mediated signal transduction","nucleotide binding /// GTP binding","intracellular","signal transduction,signaling pathway",18.8099,-1,0,4,-0.3293,0.4708]
[15,22,"203166_AT","CFDP1","craniofacial development protein 1","---","---","anti-apoptosis /// cell adhesion /// multicellular organismal development /// regulation of cell shape /// regulation of cell proliferation","---","---","cell adhesion:apoptosis:cell cycle,proliferation",5.9646,1,1.273,-6,-0.3184,0.4864]
[15,23,"221229_S_AT","FLJ20628","hypothetical protein FLJ20628","---","---","---","---","---","unknown",28.9566,1,0.0007,0,-0.1827,0.695]
[15,24,"218852_AT","PPP2R3C","protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma","---","---","---","calcium ion binding","cytoplasm","unknown",14.1891,1,0.5958,0,-0.0186,0.9683]
[15,25,"201138_S_AT","SSB","Sjogren syndrome antigen B (autoantigen La)","---","---","transcription from RNA polymerase III promoter /// RNA processing /// tRNA modification /// histone mRNA metabolic process","tRNA binding /// nucleotide binding /// nucleic acid binding /// RNA binding /// mRNA binding /// protein binding","nucleus /// ribonucleoprotein complex /// ribonucleoprotein complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process",7.3177,-1,1.9698,0,-0.4474,0.3141]
[15,26,"214274_S_AT","ACAA1","acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)","---","---","generation of precursor metabolites and energy /// lipid metabolic process /// fatty acid metabolic process","acetyl-CoA C-acyltransferase activity /// acyltransferase activity /// transferase activity","peroxisome /// peroxisome","biosynthesis,metabolism,metabolic process,biosynthetic process",6.0424,1,1.9734,0,-0.4823,0.273]
[15,27,"204131_S_AT","FOXO3","forkhead box O3","---","---","ovulation from ovarian follicle /// initiation of primordial ovarian follicle growth /// antral ovarian follicle growth /// oocyte maturation /// transcription /// regulation of transcription, DNA-dependent /// apoptosis /// apoptosis /// induction of apoptosis /// response to DNA damage stimulus /// glucose homeostasis /// positive regulation of erythrocyte differentiation /// positive regulation of transcription from RNA polymerase II promoter","DNA binding /// transcription factor activity /// transcription factor activity /// transcription activator activity /// protein kinase binding /// sequence-specific DNA binding /// sequence-specific DNA binding","membrane fraction /// nucleus /// nucleus /// cytoplasm /// cytoplasm","dna repair,transcription:cell growth,differentiation:apoptosis",6.6762,-1,0.8422,0,0.0157,0.9733]
[15,28,"218982_S_AT","MRPS17","mitochondrial ribosomal protein S17","---","---","translation /// translation /// transport","RNA binding /// structural constituent of ribosome /// structural constituent of ribosome /// binding /// rRNA binding","intracellular /// mitochondrion /// mitochondrial small ribosomal subunit /// ribosome /// membrane /// ribonucleoprotein complex","transport,ion channel",6.4734,-1,0,0,-0.1948,0.6755]
[15,29,"212945_S_AT","MGA","MAX gene associated","---","---","regulation of transcription, DNA-dependent /// regulation of transcription","DNA binding /// transcription factor activity /// transcription regulator activity","nucleus","dna repair,transcription",4.9944,-1,1.7779,0,0.2866,0.5332]
[15,30,"202151_S_AT","UBAC1","UBA domain containing 1","---","---","ubiquitin cycle","protein binding","cytoplasm",null,14.867,-1,0,0,0.3519,0.4388]
[15,31,"202829_S_AT","SYBL1","synaptobrevin-like 1","---","---","transport /// protein transport /// vesicle-mediated transport","---","endoplasmic reticulum /// membrane /// integral to membrane /// integral to membrane","transport,ion channel",6.5545,-1,0,0,-0.324,0.4784]
[15,32,"205202_AT","PCMT1","protein-L-isoaspartate (D-aspartate) O-methyltransferase","---","---","protein modification process /// protein amino acid methylation","protein-L-isoaspartate (D-aspartate) O-methyltransferase activity /// protein binding /// methyltransferase activity /// transferase activity /// identical protein binding","cytoplasm /// endoplasmic reticulum",null,9.2923,-1,0,0,-0.7058,0.0764]
[15,33,"202786_AT","STK39","serine threonine kinase 39 (STE20/SPS1 homolog, yeast)","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// response to stress","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// receptor signaling protein serine/threonine kinase activity /// protein-tyrosine kinase activity /// ATP binding /// ATP binding /// kinase activity /// transferase activity","nucleus /// cytoplasm /// cytoplasm",null,211.1996,1,0,0,-0.4693,0.2881]
[15,34,"219819_S_AT","MRPS28","mitochondrial ribosomal protein S28","---","---","---","RNA binding","mitochondrion /// mitochondrial small ribosomal subunit /// ribonucleoprotein complex","unknown",20.8969,1,1.6913,0,-0.0524,0.9112]
[15,35,"201146_AT","NFE2L2","nuclear factor (erythroid-derived 2)-like 2","---","---","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// sequence-specific DNA binding /// protein dimerization activity","nucleus /// cytoplasm","dna repair,transcription",4.8836,-1,0.3852,0,-0.5983,0.1559]
[15,36,"212693_AT","MDN1","MDN1, midasin homolog (yeast)","---","---","protein folding /// protein complex assembly /// regulation of protein complex assembly","nucleotide binding /// ATP binding /// ATPase activity /// ATPase activity /// nucleoside-triphosphatase activity /// unfolded protein binding","nucleus /// nucleus",null,8.2962,-1,0,0,0.2814,0.5409]
[15,37,"204186_S_AT","PPID","peptidylprolyl isomerase D (cyclophilin D)","---","---","protein folding","peptidyl-prolyl cis-trans isomerase activity /// binding /// protein binding /// FK506 binding /// cyclosporin A binding /// isomerase activity /// peptide binding","cytoplasm",null,8.9558,-1,0,0,-0.4686,0.2888]
[15,38,"203972_S_AT","PEX3","peroxisomal biogenesis factor 3","---","---","peroxisome organization and biogenesis /// peroxisome organization and biogenesis","protein binding","peroxisome /// peroxisome /// peroxisome /// integral to peroxisomal membrane /// integral to plasma membrane /// membrane /// integral to membrane",null,9.7707,1,0.9779,0,0.1209,0.7963]
[15,39,"200071_AT","SMNDC1","survival motor neuron domain containing 1","---","---","spliceosome assembly /// mRNA processing /// mRNA processing /// apoptosis /// induction of apoptosis /// RNA splicing /// RNA splicing","nucleic acid binding /// RNA binding /// protein binding /// RNA splicing factor activity, transesterification mechanism","nucleus /// nucleus /// spliceosome /// spliceosome /// cytoplasm","apoptosis",7.5264,-1,1.1167,0,-0.5102,0.2421]
[15,40,"208734_X_AT","RAB2A","RAB2A, member RAS oncogene family","---","---","transport /// ER to Golgi vesicle-mediated transport /// ER to Golgi vesicle-mediated transport /// small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTPase activity /// GTP binding","endoplasmic reticulum /// Golgi apparatus /// membrane","transport,ion channel:signal transduction,signaling pathway",8.6705,1,0,0,-0.3299,0.4699]
[15,41,"218323_AT","RHOT1","ras homolog gene family, member T1","---","---","apoptosis /// small GTPase mediated signal transduction /// cellular homeostasis /// mitochondrion transport along microtubule","nucleotide binding /// calcium ion binding /// GTP binding /// hydrolase activity","intracellular /// mitochondrion /// membrane /// integral to membrane /// outer membrane /// integral to mitochondrial outer membrane","transport,ion channel:apoptosis:signal transduction,signaling pathway",9.2158,-1,0,0,-0.6973,0.0816]
[15,42,"200670_AT","XBP1","X-box binding protein 1","---","---","transcription /// regulation of transcription, DNA-dependent /// immune response","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// sequence-specific DNA binding /// protein dimerization activity","nucleus /// nucleus","dna repair,transcription:immune response",9.5606,1,0,0,-0.742,0.0562]
[15,43,"203029_S_AT","PTPRN2","protein tyrosine phosphatase, receptor type, N polypeptide 2","---","---","protein amino acid dephosphorylation /// protein amino acid dephosphorylation /// dephosphorylation","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// receptor activity /// transmembrane receptor protein tyrosine phosphatase activity /// hydrolase activity /// phosphoric monoester hydrolase activity","integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane",null,7.6889,1,0,0,-0.846,0.0164]
[15,44,"201139_S_AT","SSB","Sjogren syndrome antigen B (autoantigen La)","---","---","transcription from RNA polymerase III promoter /// RNA processing /// tRNA modification /// histone mRNA metabolic process","tRNA binding /// nucleotide binding /// nucleic acid binding /// RNA binding /// mRNA binding /// protein binding","nucleus /// ribonucleoprotein complex /// ribonucleoprotein complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process",5.9154,-1,0,0,-0.1444,0.7574]
[15,45,"212530_AT","NEK7","NIMA (never in mitosis gene a)-related kinase 7","---","---","protein amino acid phosphorylation","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein-tyrosine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// metal ion binding","cytoplasm",null,4.6148,-1,0,0,-0.7275,0.0639]
[15,46,"208673_S_AT","SFRS3","splicing factor, arginine/serine-rich 3","---","---","mRNA processing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// protein binding","---",null,5.9722,-1,1.9505,0,-0.2137,0.6455]
[15,47,"204900_X_AT","SAP30","Sin3A-associated protein, 30kDa","---","---","transcription /// regulation of transcription, DNA-dependent","transcription corepressor activity /// protein binding","histone deacetylase complex","dna repair,transcription",9.9812,1,1.3625,0,-0.6885,0.0872]
[15,48,"215772_X_AT","SUCLG2","succinate-CoA ligase, GDP-forming, beta subunit","Krebs-TCA_Cycle /// Krebs-TCA_Cycle","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Krebs-TCA_Cycle/Hs_Krebs-TCA_Cycle.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Krebs-TCA_Cycle/Hs_Krebs-TCA_Cycle.htm","tricarboxylic acid cycle /// succinyl-CoA metabolic process /// metabolic process","catalytic activity /// succinate-CoA ligase (GDP-forming) activity /// succinate-CoA ligase (GDP-forming) activity /// ATP binding /// ligase activity","mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",7.3824,1,0.0007,0,-0.4475,0.314]
[15,49,"218053_AT","PRPF40A","PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA processing /// RNA splicing","protein binding","---",null,46.7936,1,0,0,-0.4108,0.3599]
[15,50,"221688_S_AT","IMP3","IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)","---","---","rRNA processing /// translation /// ribosome biogenesis and assembly","RNA binding /// protein binding /// rRNA binding","intracellular /// nucleus /// nucleolus /// ribonucleoprotein complex",null,10.1548,-1,0,0,-0.4799,0.2758]
[15,51,"218239_S_AT","GTPBP4","GTP binding protein 4","---","---","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// small GTPase mediated signal transduction /// negative regulation of DNA replication /// negative regulation of cell proliferation /// negative regulation of cell-cell adhesion /// negative regulation of cell migration /// negative regulation of protein ubiquitination /// negative regulation of collagen binding /// ribosome biogenesis and assembly /// protein stabilization","nucleotide binding /// GTPase activity /// protein binding /// GTP binding /// GTP binding","nucleus /// cytoplasm /// perinuclear region of cytoplasm","cell adhesion:cell cycle,proliferation:dna replication:signal transduction,signaling pathway",5.2079,-1,0,0,-0.2943,0.5218]
[15,52,"200655_S_AT","CALM1","calmodulin 1 (phosphorylase kinase, delta)","Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells /// G13_Signaling_Pathway /// G13_Signaling_Pathway /// G13_Signaling_Pathway /// G13_Signaling_Pathway /// Glycogen_Metabolism /// Glycogen_Metabolism /// G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// Smooth_muscle_contraction /// Smooth_muscle_contraction /// Smooth_muscle_contraction /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/physiological_process-GenMAPP/Mm_Calcium_regulation_in_cardiac_cells/Mm_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/physiological_process-GenMAPP/Rn_Calcium_regulation_in_cardiac_cells/Rn_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G13_Signaling_Pathway/Hs_G13_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/cellular_process-GenMAPP/Mm_G13_Signaling_Pathway/Mm_G13_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/cellular_process-GenMAPP/Rn_G13_Signaling_Pathway/Rn_G13_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G13_Signaling_Pathway/Hs_G13_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycogen_Metabolism/Hs_Glycogen_Metabolism.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycogen_Metabolism/Hs_Glycogen_Metabolism.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/cellular_process-GenMAPP/Mm_G_Protein_Signaling/Mm_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/cellular_process-GenMAPP/Rn_G_Protein_Signaling/Rn_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/physiological_process-GenMAPP/Mm_Smooth_muscle_contraction/Mm_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/physiological_process-GenMAPP/Rn_Smooth_muscle_contraction/Rn_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","G-protein coupled receptor protein signaling pathway","calcium ion binding /// calcium ion binding /// protein binding /// protein binding /// protein binding /// N-terminal myristoylation domain binding","cytoplasm /// plasma membrane","signal transduction,signaling pathway",6.1531,-1,0.8161,0,-0.6502,0.1138]
[15,53,"201019_S_AT","EIF1AP1 /// EIF1AX","eukaryotic translation initiation factor 1A, X-linked /// eukaryotic translation initiation factor 1A pseudogene 1","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation","RNA binding /// translation initiation factor activity /// translation factor activity, nucleic acid binding","eukaryotic translation initiation factor 4F complex",null,6.5117,1,0.9808,0,-0.3556,0.4338]
[15,54,"218238_AT","GTPBP4","GTP binding protein 4","---","---","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// small GTPase mediated signal transduction /// negative regulation of DNA replication /// negative regulation of cell proliferation /// negative regulation of cell-cell adhesion /// negative regulation of cell migration /// negative regulation of protein ubiquitination /// negative regulation of collagen binding /// ribosome biogenesis and assembly /// protein stabilization","nucleotide binding /// GTPase activity /// protein binding /// GTP binding /// GTP binding","nucleus /// cytoplasm /// perinuclear region of cytoplasm","cell adhesion:cell cycle,proliferation:dna replication:signal transduction,signaling pathway",5.4749,-1,1.8106,0,-0.1968,0.6723]
[15,55,"202126_AT","PRPF4B","PRP4 pre-mRNA processing factor 4 homolog B (yeast)","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA processing /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// RNA splicing /// RNA splicing","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","spliceosome",null,5.3821,-1,1.1335,0,-0.494,0.2598]
[15,56,"212131_AT","LSM14A","LSM14A, SCD6 homolog A (S. cerevisiae)","---","---","---","---","---","unknown",5.1649,-1,0,0,-0.2084,0.6538]
[15,57,"213102_AT","ACTR3","ARP3 actin-related protein 3 homolog (yeast)","---","---","cell motility","nucleotide binding /// structural molecule activity /// protein binding /// protein binding /// ATP binding","cytoplasm /// cytoskeleton /// Arp2/3 protein complex /// actin cytoskeleton /// lamellipodium",null,7.4329,-1,0,0,-0.5179,0.2338]
[15,58,"203148_S_AT","TRIM14","tripartite motif-containing 14","---","---","compartment specification","protein binding /// zinc ion binding /// metal ion binding","intracellular /// cytoplasm",null,6.8979,1,0,0,-0.8903,0.0072]
[15,59,"201661_S_AT","ACSL3","acyl-CoA synthetase long-chain family member 3","Fatty_Acid_Degradation /// Fatty_Acid_Degradation /// Mitochondrial_fatty_acid_betaoxidation /// Mitochondrial_fatty_acid_betaoxidation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Degradation/Hs_Fatty_Acid_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Degradation/Hs_Fatty_Acid_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Mitochondrial_fatty_acid_betaoxidation/Hs_Mitochondrial_fatty_acid_betaoxidation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Mitochondrial_fatty_acid_betaoxidation/Hs_Mitochondrial_fatty_acid_betaoxidation.htm","lipid metabolic process /// fatty acid metabolic process /// metabolic process","magnesium ion binding /// catalytic activity /// fatty-acyl-CoA synthase activity /// long-chain-fatty-acid-CoA ligase activity /// protein binding /// ligase activity","mitochondrion /// peroxisome /// endoplasmic reticulum /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",5.7753,1,1.7454,0,-0.6962,0.0823]
[15,60,"211953_S_AT","RANBP5","RAN binding protein 5","---","---","protein import into nucleus, docking /// NLS-bearing substrate import into nucleus /// transport /// intracellular protein transport /// protein transport","GTPase inhibitor activity /// binding /// protein binding /// nuclear localization sequence binding /// Ran GTPase binding /// protein transporter activity","nucleus /// nucleus /// nuclear pore /// nuclear pore /// cytoplasm /// cytoplasm","transport,ion channel",8.5067,1,0,0,-0.4138,0.3561]
[15,61,"203403_S_AT","RNF6","ring finger protein (C3H2C3 type) 6","---","---","ubiquitin-dependent protein catabolic process /// negative regulation of axon extension /// positive regulation of transcription, DNA-dependent","DNA binding /// ubiquitin-protein ligase activity /// protein binding /// zinc ion binding /// zinc ion binding /// transcription activator activity /// metal ion binding","cytoplasm /// PML body /// axon","dna repair,transcription",7.1475,-1,0.0232,0,-0.5357,0.2153]
[15,62,"210283_X_AT","PAIP1","poly(A) binding protein interacting protein 1","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translational initiation /// regulation of translation /// RNA metabolic process /// mRNA stabilization","RNA binding /// protein binding /// protein binding /// translation activator activity","cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",6.412,-1,0,0,-0.569,0.1825]
[15,63,"201018_AT","EIF1AX","eukaryotic translation initiation factor 1A, X-linked","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation","RNA binding /// translation initiation factor activity /// translation factor activity, nucleic acid binding","eukaryotic translation initiation factor 4F complex",null,5.9102,1,0,0,-0.103,0.826]
[15,64,"217941_S_AT","ERBB2IP","erbb2 interacting protein","---","---","cell cycle /// cell adhesion /// signal transduction /// epidermal growth factor receptor signaling pathway /// integrin-mediated signaling pathway /// cell growth /// intermediate filament cytoskeleton organization and biogenesis /// basal protein localization /// establishment and/or maintenance of epithelial cell polarity","ErbB-2 class receptor binding /// integrin binding /// integrin binding /// structural constituent of cytoskeleton /// protein binding /// protein binding /// protein binding","basement membrane /// nucleus /// nucleus /// cytoplasm /// cytoplasm /// basal plasma membrane /// cell junction /// hemidesmosome /// hemidesmosome","cell growth,differentiation:cell adhesion:cell cycle,proliferation:nuclear matrix,cytoskeleton:signal transduction,signaling pathway",7.9542,-1,0,0,-0.701,0.0793]
[15,65,"222035_S_AT","PAPOLA","poly(A) polymerase alpha","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","transcription /// mRNA polyadenylation /// mRNA processing /// RNA polyadenylation","RNA binding /// RNA binding /// polynucleotide adenylyltransferase activity /// transferase activity /// nucleotidyltransferase activity","nucleus /// nucleus /// cytoplasm /// cytoplasm","dna repair,transcription",8.8938,-1,0,0,-0.3437,0.4503]
[15,66,"209274_S_AT","ISCA1","iron-sulfur cluster assembly 1 homolog (S. cerevisiae)","---","---","---","iron ion binding /// metal ion binding /// iron-sulfur cluster binding","mitochondrion","unknown",8.5414,1,0.0493,0,-0.2557,0.5799]
[15,67,"203782_S_AT","POLRMT","polymerase (RNA) mitochondrial (DNA directed)","---","---","DNA replication, synthesis of RNA primer /// transcription","DNA binding /// DNA-directed RNA polymerase activity /// transferase activity /// nucleotidyltransferase activity","mitochondrion /// mitochondrion","dna repair,transcription:dna replication",11.1345,1,0,0,0.3227,0.4802]
[15,68,"202156_S_AT","CUGBP2","CUG triplet repeat, RNA binding protein 2","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA processing","nucleotide binding /// nucleic acid binding /// RNA binding","cytoplasm",null,7.8818,1,1.285,0,-0.7389,0.0578]
[15,69,"218889_AT","NOC3L","nucleolar complex associated 3 homolog (S. cerevisiae)","---","---","---","binding","---","unknown",7.7011,-1,0,0,-0.1899,0.6834]
[15,70,"212689_S_AT","JMJD1A","jumonji domain containing 1A","---","---","transcription /// regulation of transcription, DNA-dependent /// chromatin modification","iron ion binding /// zinc ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// metal ion binding","---","dna repair,transcription",7.653,1,0,0,-0.3834,0.3959]
[15,71,"201501_S_AT","GRSF1","G-rich RNA sequence binding factor 1","---","---","mRNA polyadenylation /// anterior/posterior pattern formation /// morphogenesis of embryonic epithelium","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// mRNA binding","cytoplasm /// cytoplasm",null,6.9807,-1,0,0,-0.5231,0.2283]
[15,72,"201811_X_AT","SH3BP5","SH3-domain binding protein 5 (BTK-associated)","---","---","signal transduction /// intracellular signaling cascade","protein kinase inhibitor activity /// SH3/SH2 adaptor activity /// protein binding","cytoplasm /// mitochondrion","signal transduction,signaling pathway",7.4865,-1,0,0,-0.9242,0.0029]
[15,73,"202076_AT","BIRC2","baculoviral IAP repeat-containing 2","Apoptosis /// Apoptosis_GenMAPP","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm","placenta development /// apoptosis /// anti-apoptosis /// cell surface receptor linked signal transduction /// regulation of apoptosis /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// protein binding /// protein binding /// zinc ion binding /// metal ion binding","intracellular /// cytoplasm","apoptosis:signal transduction,signaling pathway",8.2686,-1,0,0,-0.2116,0.6487]
[15,74,"201193_AT","IDH1","isocitrate dehydrogenase 1 (NADP+), soluble","---","---","carbohydrate metabolic process /// glyoxylate cycle /// tricarboxylic acid cycle /// isocitrate metabolic process /// glutathione metabolic process /// response to oxidative stress /// metabolic process","magnesium ion binding /// isocitrate dehydrogenase (NADP+) activity /// isocitrate dehydrogenase (NADP+) activity /// oxidoreductase activity /// oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor /// manganese ion binding /// metal ion binding","cytoplasm /// cytoplasm /// peroxisome /// cytosol /// cytosol","biosynthesis,metabolism,metabolic process,biosynthetic process",5.8585,-1,0,0,-0.7747,0.0408]
[15,75,"219330_AT","VANGL1","vang-like 1 (van gogh, Drosophila)","---","---","multicellular organismal development","protein binding","membrane /// integral to membrane",null,24.2437,-1,0,0,-0.6709,0.099]
[15,76,"212515_S_AT","DDX3X","DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked","---","---","---","nucleotide binding /// nucleic acid binding /// DNA binding /// RNA binding /// ATP-dependent RNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","nucleus /// cytoplasm /// cytoplasm","unknown",8.2194,-1,0,0,-0.1284,0.7838]
[15,77,"209267_S_AT","SLC39A8","solute carrier family 39 (zinc transporter), member 8","---","---","metal ion transport","metal ion transmembrane transporter activity","membrane","transport,ion channel",6.2679,-1,0,0,-0.5434,0.2075]
[15,78,"207957_S_AT","PRKCB1","protein kinase C, beta 1","Calcium_regulation_in_cardiac_cells /// G_Protein_Signaling /// Smooth_muscle_contraction /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","protein amino acid phosphorylation /// protein amino acid phosphorylation /// calcium ion transport /// cellular calcium ion homeostasis /// signal transduction /// intracellular signaling cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein kinase C activity /// protein kinase C activity /// calcium channel regulator activity /// calcium ion binding /// protein binding /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding","nucleus /// cytoplasm /// cytoplasm /// plasma membrane /// membrane","transport,ion channel:signal transduction,signaling pathway",6.6533,-1,0,0,-0.4645,0.2937]
[]
[null,null,16]
[16,1,"204563_AT","SELL","selectin L (lymphocyte adhesion molecule 1)","---","---","cell motility /// cell adhesion /// cell adhesion","protein binding /// sugar binding /// carbohydrate binding","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","cell adhesion",7.4948,1,1.3354,6,-0.9546,0.0008]
[16,2,"203476_AT","TPBG","trophoblast glycoprotein","---","---","cell motility /// cell adhesion","protein binding","integral to plasma membrane /// membrane /// integral to membrane","cell adhesion",3.2153,1,0,6,-0.5657,0.1856]
[16,3,"208490_X_AT","HIST1H2BF","histone cluster 1, H2bf","---","---","nucleosome assembly /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// defense response to bacterium","DNA binding /// DNA binding /// protein binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,4.5726,1,0,4,-0.4786,0.2773]
[16,4,"220429_AT","NDST3","N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3","---","---","protein amino acid deacetylation /// protein amino acid sulfation","catalytic activity /// sulfotransferase activity /// [heparan sulfate]-glucosamine N-sulfotransferase activity /// transferase activity /// hydrolase activity","membrane /// integral to membrane",null,10.3383,1,0,4,-0.8379,0.0186]
[16,5,"203695_S_AT","DFNA5","deafness, autosomal dominant 5","---","---","sensory perception of sound /// sensory perception of sound /// hair cell differentiation","---","---","cell growth,differentiation",0.5244,1,0.4969,0,-0.0838,0.8582]
[16,6,"207826_S_AT","ID3","inhibitor of DNA binding 3, dominant negative helix-loop-helix protein","---","---","negative regulation of transcription from RNA polymerase II promoter /// multicellular organismal development /// heart development /// negative regulation of transcription /// epithelial cell differentiation /// negative regulation of transcription factor activity /// regulation of transcription","transcription corepressor activity /// protein binding /// transcription repressor activity /// protein domain specific binding /// transcription regulator activity","nucleus /// nucleus","dna repair,transcription:cell growth,differentiation",5.2733,1,0,4,-0.6606,0.1062]
[16,7,"209911_X_AT","HIST1H2BD","histone cluster 1, H2bd","---","---","nucleosome assembly /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// defense response to bacterium","DNA binding /// DNA binding /// protein binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,4.4627,1,0,4,-0.6848,0.0896]
[16,8,"203921_AT","CHST2","carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2","---","---","carbohydrate metabolic process /// N-acetylglucosamine metabolic process /// sulfur metabolic process /// inflammatory response /// inflammatory response /// multicellular organismal development","N-acetylglucosamine 6-O-sulfotransferase activity /// sulfotransferase activity /// sulfotransferase activity /// transferase activity","trans-Golgi network /// membrane /// integral to membrane /// intrinsic to Golgi membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",9.1037,1,0,0,-0.7176,0.0694]
[16,9,"201858_S_AT","SRGN","serglycin","---","---","ossification /// apoptosis /// apoptosis /// negative regulation of bone mineralization /// mast cell secretory granule organization and biogenesis /// T cell secretory granule organization and biogenesis /// maintenance of protease localization in mast cell secretory granule /// maintenance of granzyme B localization in T cell secretory granule /// negative regulation of cytokine secretion /// protein maturation via proteolysis","protein binding /// protein binding","extracellular space /// Golgi apparatus /// mast cell granule","apoptosis:proteolysis",5.4496,1,1.3736,0,-0.8682,0.0113]
[16,10,"218241_AT","GOLGA5","golgi autoantigen, golgin subfamily a, 5","---","---","protein amino acid phosphorylation /// Golgi organization and biogenesis /// Golgi vesicle transport","protein-tyrosine kinase activity /// ATP binding /// Rab GTPase binding /// protein homodimerization activity","Golgi apparatus /// cis-Golgi network /// membrane /// integral to membrane /// integral to membrane /// Golgi cisterna","transport,ion channel",8.953,1,1.9592,0,-0.7342,0.0603]
[16,11,"202478_AT","TRIB2","tribbles homolog 2 (Drosophila)","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// regulation of MAPK activity","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein kinase inhibitor activity /// protein binding /// ATP binding","cytoplasm /// cytoplasm /// cytoskeleton",null,8.65,-1,0.0044,0,-0.9198,0.0033]
[16,12,"218806_S_AT","VAV3","vav 3 guanine nucleotide exchange factor","Integrin-mediated_cell_adhesion_KEGG /// Integrin-mediated_cell_adhesion_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm","intracellular signaling cascade /// small GTPase mediated signal transduction /// regulation of Rho protein signal transduction","SH3/SH2 adaptor activity /// guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity /// GTPase activator activity /// zinc ion binding /// diacylglycerol binding /// metal ion binding","intracellular","signal transduction,signaling pathway",9.8569,1,1.9166,0,-0.8947,0.0065]
[16,13,"204484_AT","PIK3C2B","phosphoinositide-3-kinase, class 2, beta polypeptide","S1P_Signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_S1P_Signaling/Hs_S1P_Signaling.htm","cell communication","inositol or phosphatidylinositol kinase activity /// protein binding /// protein binding /// kinase activity /// 1-phosphatidylinositol-3-kinase activity /// transferase activity /// phosphotransferase activity, alcohol group as acceptor /// phosphatidylinositol-4-phosphate 3-kinase activity /// phosphatidylinositol-4-phosphate 3-kinase activity /// phosphoinositide binding","cytoplasm /// endoplasmic reticulum /// microsome /// microsome /// cytosol /// plasma membrane /// phosphoinositide 3-kinase complex /// membrane",null,4.9325,1,0,0,-0.8499,0.0154]
[16,14,"222067_X_AT","HIST1H2BD","histone cluster 1, H2bd","---","---","nucleosome assembly /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// defense response to bacterium","DNA binding /// DNA binding /// protein binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,3.9735,1,0,0,-0.5726,0.1791]
[16,15,"212249_AT","PIK3R1","phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)","---","---","signal transduction /// intracellular signaling cascade /// intracellular signaling cascade /// insulin receptor signaling pathway /// phosphoinositide phosphorylation /// insulin-like growth factor receptor signaling pathway","insulin receptor binding /// insulin-like growth factor receptor binding /// protein binding /// phosphatidylinositol binding /// protein phosphatase binding /// phosphoinositide 3-kinase regulator activity /// phosphoinositide 3-kinase regulator activity /// ErbB-3 class receptor binding /// insulin binding /// insulin receptor substrate binding","intracellular /// phosphoinositide 3-kinase complex /// phosphoinositide 3-kinase complex, class IA","signal transduction,signaling pathway",11.7006,1,1.3123,0,-0.5321,0.2189]
[16,16,"218723_S_AT","C13orf15","chromosome 13 open reading frame 15","---","---","cell cycle","protein binding","cytoplasm","cell cycle,proliferation",11.701,1,0,0,-0.8758,0.0098]
[16,17,"205544_S_AT","CR2","complement component (3d/Epstein Barr virus) receptor 2","---","---","immune response /// immune response /// complement activation, classical pathway /// innate immune response","receptor activity /// complement receptor activity /// complement receptor activity /// transmembrane receptor activity /// protein homodimerization activity","plasma membrane /// membrane /// integral to membrane /// integral to membrane","immune response",8.1687,1,0,0,-0.9897,0]
[16,18,"204317_AT","GTSE1","G-2 and S-phase expressed 1","---","---","G2 phase of mitotic cell cycle /// DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest /// microtubule-based process","---","cytoplasm /// microtubule /// cytoplasmic microtubule","cell cycle,proliferation:signal transduction,signaling pathway",9.025,1,0,0,-0.8123,0.0264]
[16,19,"215509_S_AT","BUB1","BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","protein amino acid phosphorylation /// cell cycle /// mitosis /// mitotic cell cycle checkpoint /// mitotic cell cycle spindle assembly checkpoint /// cell proliferation /// cell division","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity","kinetochore /// spindle pole body","cell cycle,proliferation",7.0577,1,1.7418,0,-0.8536,0.0145]
[16,20,"214805_AT","EIF4A1","Eukaryotic translation initiation factor 4A, isoform 1","---","---","translation","nucleotide binding /// RNA cap binding /// nucleic acid binding /// RNA binding /// mRNA binding /// translation initiation factor activity /// helicase activity /// helicase activity /// protein binding /// ATP binding /// ATP-dependent helicase activity /// translation factor activity, nucleic acid binding /// hydrolase activity","eukaryotic translation initiation factor 4F complex",null,3.4231,1,0,0,-0.3179,0.4871]
[16,21,"213261_AT","LBA1","lupus brain antigen 1","---","---","DNA repair","DNA binding /// ATP-dependent DNA helicase activity /// ATP binding","---","dna repair,transcription",1.4406,1,0.0003,0,-0.1044,0.8238]
[16,22,"201753_S_AT","ADD3","adducin 3 (gamma)","---","---","---","structural constituent of cytoskeleton /// calmodulin binding /// metal ion binding","cytoplasm /// cytoskeleton /// membrane /// membrane","unknown",10.9409,1,0,0,-0.9945,0]
[16,23,"203817_AT","GUCY1B3","guanylate cyclase 1, soluble, beta 3","---","---","cGMP biosynthetic process /// intracellular signaling cascade /// nitric oxide mediated signal transduction /// circulation /// cyclic nucleotide biosynthetic process","guanylate cyclase activity /// guanylate cyclase activity /// receptor activity /// iron ion binding /// lyase activity /// phosphorus-oxygen lyase activity /// heme binding /// metal ion binding","cytoplasm /// cytoplasm /// guanylate cyclase complex, soluble","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway",6.2319,1,0,0,-0.8669,0.0115]
[16,24,"220418_AT","UBASH3A","ubiquitin associated and SH3 domain containing, A","---","---","---","---","cytoplasm /// cytoplasm","unknown",13.4363,1,0,0,-0.861,0.0128]
[16,25,"204352_AT","TRAF5","TNF receptor-associated factor 5","---","---","apoptosis /// signal transduction /// signal transduction /// regulation of apoptosis /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// receptor activity /// protein binding /// protein binding /// zinc ion binding /// metal ion binding","cytoplasm","apoptosis:signal transduction,signaling pathway",13.0861,1,0,0,-0.9071,0.0048]
[16,26,"221591_S_AT","FAM64A","family with sequence similarity 64, member A","---","---","---","---","---","unknown",8.6694,1,0,0,-0.8196,0.024]
[16,27,"209879_AT","SELPLG","selectin P ligand","---","---","cell adhesion /// cell adhesion","receptor binding /// protein binding /// sugar binding /// bacterial binding","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane","cell adhesion",13.0819,1,0,0,-0.7909,0.0342]
[16,28,"202240_AT","PLK1","polo-like kinase 1 (Drosophila)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of progression through cell cycle /// protein amino acid phosphorylation /// mitosis /// cell proliferation","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// protein binding /// ATP binding /// kinase activity /// transferase activity","centrosome","cell cycle,proliferation",18.839,1,0,0,-0.9462,0.0013]
[16,29,"206283_S_AT","TAL1","T-cell acute lymphocytic leukemia 1","Pentose_Phosphate_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Pentose_Phosphate_Pathway/Hs_Pentose_Phosphate_Pathway.htm","transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development /// cell proliferation /// hemopoiesis /// cell differentiation /// erythrocyte differentiation /// cell fate commitment /// regulation of transcription","DNA binding /// DNA binding /// protein binding /// transcription regulator activity","nucleus","dna repair,transcription:cell growth,differentiation:cell cycle,proliferation",21.7042,1,0,0,-0.8484,0.0158]
[16,30,"210074_AT","CTSL2","cathepsin L2","---","---","proteolysis","cysteine-type endopeptidase activity /// cathepsin L activity /// protein binding /// peptidase activity /// cysteine-type peptidase activity /// cysteine-type peptidase activity /// hydrolase activity","lysosome","proteolysis",1.1832,1,1.5207,0,-0.3079,0.5018]
[16,31,"221922_AT","GPSM2","G-protein signaling modulator 2 (AGS3-like, C. elegans)","---","---","signal transduction /// G-protein coupled receptor protein signaling pathway","GTPase activator activity /// binding /// protein binding /// identical protein binding","cytoplasm","signal transduction,signaling pathway",15.7762,1,0,0,-0.9643,0.0005]
[]
[null,null,17]
[17,1,"221486_AT","ENSA","endosulfine alpha","---","---","transport /// response to nutrient","receptor binding /// protein binding /// ion channel inhibitor activity","cytoplasm","transport,ion channel",4.0835,-1,0.3446,-2,0.5567,0.1943]
[17,2,"213750_AT","RSL1D1","ribosomal L1 domain containing 1","---","---","translation","structural constituent of ribosome /// protein binding","intracellular /// ribosome",null,6.2142,1,0,-4,-0.0583,0.9012]
[17,3,"209732_AT","CLEC2B","C-type lectin domain family 2, member B","---","---","---","sugar binding /// sugar binding","integral to plasma membrane /// membrane /// integral to membrane","unknown",7.7949,1,0,-2,-0.3943,0.3814]
[17,4,"204175_AT","ZNF593","zinc finger protein 593","---","---","negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// transcription corepressor activity /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription",4.1014,1,0.0209,-2,0.2242,0.6289]
[17,5,"212644_S_AT","C14orf32","chromosome 14 open reading frame 32","---","---","---","---","---","unknown",3.6457,1,0,-4,0.0526,0.9109]
[17,6,"204794_AT","DUSP2","dual specificity phosphatase 2","---","---","inactivation of MAPK activity /// protein amino acid dephosphorylation /// protein amino acid dephosphorylation /// dephosphorylation","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine/serine/threonine phosphatase activity /// protein tyrosine/threonine phosphatase activity /// hydrolase activity /// phosphoric monoester hydrolase activity /// MAP kinase tyrosine/serine/threonine phosphatase activity /// mitogen-activated protein kinase binding","nucleus",null,4.9511,-1,1.1618,-4,-0.2932,0.5234]
[17,7,"201020_AT","YWHAH","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide","Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells /// Smooth_muscle_contraction /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","glucocorticoid catabolic process /// intracellular protein transport /// intracellular protein transport /// glucocorticoid receptor signaling pathway /// regulation of neuron differentiation /// positive regulation of transcription /// regulation of synaptic plasticity /// negative regulation of dendrite morphogenesis /// negative regulation of dendrite morphogenesis","actin binding /// actin binding /// insulin-like growth factor receptor binding /// protein binding /// protein binding /// protein binding /// transcription activator activity /// protein domain specific binding /// protein domain specific binding /// glucocorticoid receptor binding","cytoplasm /// cytoplasm","dna repair,transcription:cell growth,differentiation:transport,ion channel:signal transduction,signaling pathway",6.4179,-1,1.4638,-4,0.0131,0.9778]
[17,8,"202514_AT","DLG1","discs, large homolog 1 (Drosophila)","---","---","endothelial cell proliferation /// endothelial cell proliferation /// actin filament organization /// actin filament organization /// establishment and/or maintenance of cell polarity /// cell-cell adhesion /// cell-cell adhesion /// cortical actin cytoskeleton organization and biogenesis /// cortical actin cytoskeleton organization and biogenesis /// G1/S transition checkpoint /// negative regulation of progression through mitotic cell cycle /// negative regulation of progression through mitotic cell cycle","guanylate kinase activity /// phosphoprotein phosphatase activity /// protein binding /// protein binding /// protein binding /// protein C-terminus binding /// cytoskeletal protein binding /// potassium channel regulator activity /// protein kinase binding /// protein kinase binding /// phosphatase binding /// phosphatase binding","endoplasmic reticulum /// plasma membrane /// intercellular junction /// membrane /// basolateral plasma membrane /// basolateral plasma membrane /// cell junction /// cell junction /// synapse","cell adhesion:cell cycle,proliferation:nuclear matrix,cytoskeleton",8.5772,1,0,-2,0.4043,0.3684]
[17,9,"221277_S_AT","PUS3","pseudouridylate synthase 3","---","---","tRNA processing /// tRNA pseudouridine synthesis","pseudouridylate synthase activity /// tRNA-pseudouridine synthase activity /// isomerase activity","---",null,3.6044,1,0,-4,0.0678,0.8852]
[17,10,"211105_S_AT","NFATC1","nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1","---","---","G1/S transition of mitotic cell cycle /// epithelial to mesenchymal transition /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// calcium ion transport /// intracellular signaling cascade /// heart development /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// FK506 binding /// transcription activator activity","nucleus /// cytoplasm /// cytoplasm","dna repair,transcription:transport,ion channel:cell cycle,proliferation",6.897,1,1.2517,-4,-0.9372,0.0018]
[17,11,"201633_S_AT","CYB5B","cytochrome b5 type B (outer mitochondrial membrane)","---","---","electron transport /// transport","iron ion binding /// heme binding /// metal ion binding /// transition metal ion binding","mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane /// outer membrane","transport,ion channel",6.7449,1,0,0,-0.2452,0.5962]
[17,12,"212501_AT","CEBPB","CCAAT/enhancer binding protein (C/EBP), beta","Circadian_Exercise /// Circadian_Exercise /// Circadian_Exercise /// Ovarian_Infertility_Genes /// Ovarian_Infertility_Genes /// Ovarian_Infertility_Genes","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm","embryonic placenta development /// transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// anti-apoptosis /// induction of apoptosis /// acute-phase response /// inflammatory response /// immune response /// neuron differentiation /// regulation of interleukin-6 biosynthetic process /// fat cell differentiation /// positive regulation of transcription","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// protein binding /// protein binding /// transcription activator activity /// protein homodimerization activity /// sequence-specific DNA binding /// protein heterodimerization activity /// protein dimerization activity","nucleus /// nucleus /// cytoplasm","dna repair,transcription:cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:immune response",7.162,-1,0,-2,-0.3072,0.5028]
[17,13,"217766_S_AT","TMEM50A","transmembrane protein 50A","---","---","---","---","cytoplasm /// endoplasmic reticulum /// membrane /// integral to membrane","unknown",6.5171,1,0,0,-0.4851,0.2698]
[17,14,"218590_AT","PEO1","progressive external ophthalmoplegia 1","---","---","DNA replication","nucleotide binding /// DNA helicase activity /// helicase activity /// ATP binding /// hydrolase activity","mitochondrion","dna replication",8.3386,-1,0.4698,-2,0.2227,0.6313]
[17,15,"213789_AT","TBC1D25","TBC1 domain family, member 25","---","---","skeletal development /// steroid biosynthetic process /// cholesterol biosynthetic process /// cholesterol metabolic process /// lipid biosynthetic process /// sterol metabolic process /// sterol biosynthetic process /// hemopoiesis /// regulation of Rab GTPase activity","C-8 sterol isomerase activity /// steroid delta-isomerase activity /// transmembrane receptor activity /// GTPase activator activity /// Rab GTPase activator activity /// drug transporter activity /// isomerase activity /// cholestenol delta-isomerase activity","intracellular /// endoplasmic reticulum /// endoplasmic reticulum /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",3.9859,1,0.0036,0,0.5904,0.1629]
[17,16,"201548_S_AT","JARID1B","jumonji, AT rich interactive domain 1B","---","---","transcription /// regulation of transcription, DNA-dependent /// protein amino acid phosphorylation /// chromatin modification /// negative regulation of transcription, DNA-dependent","DNA binding /// DNA binding /// protein kinase activity /// iron ion binding /// protein binding /// protein binding /// ATP binding /// zinc ion binding /// oxidoreductase activity /// transcription repressor activity /// oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// metal ion binding","intracellular /// nucleus /// nucleus","dna repair,transcription",7.0879,1,0,0,-0.5116,0.2405]
[17,17,"207543_S_AT","P4HA1","procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I","---","---","protein metabolic process","procollagen-proline 4-dioxygenase activity /// procollagen-proline 4-dioxygenase activity /// binding /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors /// L-ascorbic acid binding /// metal ion binding","endoplasmic reticulum /// endoplasmic reticulum","biosynthesis,metabolism,metabolic process,biosynthetic process",6.7223,-1,0,0,-0.3161,0.4898]
[17,18,"205763_S_AT","DDX18","DEAD (Asp-Glu-Ala-Asp) box polypeptide 18","---","---","---","nucleotide binding /// nucleic acid binding /// RNA binding /// ATP-dependent RNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","---","unknown",7.8597,-1,0,-2,0.209,0.6528]
[17,19,"202934_AT","HK2","hexokinase 2","Glycolysis_and_Gluconeogenesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm","regulation of progression through cell cycle /// glucose metabolic process /// glucose metabolic process /// glucose catabolic process /// glycolysis /// carbohydrate phosphorylation","nucleotide binding /// catalytic activity /// hexokinase activity /// hexokinase activity /// ATP binding /// kinase activity /// transferase activity","mitochondrion /// mitochondrial outer membrane /// membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",4.496,-1,0,-2,-0.1997,0.6677]
[17,20,"217738_AT","PBEF1","pre-B-cell colony enhancing factor 1","---","---","signal transduction /// cell-cell signaling /// positive regulation of cell proliferation /// pyridine nucleotide biosynthetic process","nicotinate phosphoribosyltransferase activity /// cytokine activity /// transferase activity /// transferase activity, transferring glycosyl groups /// nicotinamide phosphoribosyltransferase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",6.604,1,1.3046,-2,-0.0123,0.9792]
[17,21,"214437_S_AT","SHMT2","serine hydroxymethyltransferase 2 (mitochondrial)","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational elongation /// translational elongation /// glycine metabolic process /// L-serine metabolic process /// one-carbon compound metabolic process","translation elongation factor activity /// translation elongation factor activity /// catalytic activity /// glycine hydroxymethyltransferase activity /// protein binding /// methyltransferase activity /// transferase activity /// pyridoxal phosphate binding","intracellular /// mitochondrion /// mitochondrion /// eukaryotic translation elongation factor 1 complex","biosynthesis,metabolism,metabolic process,biosynthetic process",5.0628,1,1.3864,-2,0.3212,0.4823]
[17,22,"202683_S_AT","RNMT","RNA (guanine-7-) methyltransferase","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA capping /// mRNA capping /// mRNA capping /// mRNA processing","RNA binding /// RNA binding /// RNA binding /// mRNA (guanine-N7-)-methyltransferase activity /// mRNA (guanine-N7-)-methyltransferase activity /// mRNA (guanine-N7-)-methyltransferase activity /// methyltransferase activity /// transferase activity","nucleus /// nucleus",null,4.3838,1,1.1172,-4,0.1839,0.6931]
[17,23,"212514_X_AT","DDX3X","DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked","---","---","---","nucleotide binding /// nucleic acid binding /// DNA binding /// RNA binding /// ATP-dependent RNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","nucleus /// cytoplasm /// cytoplasm","unknown",8.6913,-1,0.7118,0,0.213,0.6466]
[17,24,"219045_AT","RHOF","ras homolog gene family, member F (in filopodia)","---","---","actin filament organization /// small GTPase mediated signal transduction","nucleotide binding /// GTPase activity /// GTP binding","intracellular /// cytoplasm /// cytoskeleton /// cytoskeleton /// membrane","signal transduction,signaling pathway",10.468,1,0,-2,-0.7657,0.0448]
[17,25,"212300_AT","TXLNA","taxilin alpha","---","---","exocytosis /// cell proliferation","cytokine activity /// high molecular weight B cell growth factor receptor binding","extracellular region /// cytoplasm","cell cycle,proliferation",3.8778,-1,0,-2,0.4233,0.3439]
[17,26,"214229_AT","DNAH17","dynein, axonemal, heavy chain 17","---","---","microtubule-based movement","microtubule motor activity","dynein complex",null,7.2721,1,0.0008,-4,0.6939,0.0837]
[17,27,"203530_S_AT","STX4","syntaxin 4","---","---","transport /// neurotransmitter transport /// intracellular protein transport /// vesicle-mediated transport","protein binding /// protein binding /// protein transporter activity","cytoplasm /// plasma membrane /// membrane /// membrane /// integral to membrane","transport,ion channel",8.0684,1,0.0001,-2,0.5174,0.2343]
[17,28,"220688_S_AT","MRTO4","mRNA turnover 4 homolog (S. cerevisiae)","---","---","ribosome biogenesis and assembly","---","intracellular",null,6.9752,-1,1.4464,-4,0.3056,0.5051]
[17,29,"205996_S_AT","AK2","adenylate kinase 2","---","---","nucleobase, nucleoside, nucleotide and nucleic acid metabolic process","nucleotide binding /// adenylate kinase activity /// adenylate kinase activity /// ATP binding /// kinase activity /// transferase activity /// phosphotransferase activity, phosphate group as acceptor /// nucleotide kinase activity /// nucleoside kinase activity","mitochondrion /// mitochondrial inner membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",5.2488,1,0,-4,0.0865,0.8538]
[17,30,"207438_S_AT","SNUPN","snurportin 1","---","---","protein import into nucleus /// transport /// intracellular protein transport","RNA cap binding /// RNA binding /// protein transporter activity","nucleus /// nuclear pore /// nuclear pore /// cytoplasm","transport,ion channel",5.1676,-1,1.4024,0,0.3997,0.3743]
[17,31,"212333_AT","FAM98A","family with sequence similarity 98, member A","---","---","---","phosphopantetheine binding","---","unknown",9.8804,-1,0.1084,0,-0.0102,0.9827]
[17,32,"212561_AT","RAB6IP1","RAB6 interacting protein 1","---","---","---","protein binding /// Rab GTPase binding","---","unknown",5.2107,1,0,-4,-0.2017,0.6645]
[17,33,"204998_S_AT","ATF5","activating transcription factor 5","Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","regulation of progression through cell cycle /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// regulation of transcription from RNA polymerase II promoter /// anti-apoptosis","DNA binding /// transcription factor activity /// RNA polymerase II transcription factor activity /// RNA polymerase II transcription factor activity /// transcription corepressor activity /// protein binding /// sequence-specific DNA binding /// protein dimerization activity","nucleus /// transcription factor complex /// cytoplasm","dna repair,transcription:apoptosis:cell cycle,proliferation",8.8499,-1,0,-4,0.0257,0.9564]
[17,34,"209317_AT","POLR1C","polymerase (RNA) I polypeptide C, 30kDa","---","---","transcription /// transcription from RNA polymerase I promoter","DNA binding /// DNA-directed RNA polymerase activity /// DNA-directed RNA polymerase activity /// protein dimerization activity","nucleus /// DNA-directed RNA polymerase I complex","dna repair,transcription",9.7279,1,1.4074,-2,0.0708,0.8801]
[17,35,"203818_S_AT","SF3A3","splicing factor 3a, subunit 3, 60kDa","Circadian_Exercise /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","nuclear mRNA 3'-splice site recognition /// nuclear mRNA splicing, via spliceosome /// mRNA processing /// mRNA processing /// mRNA processing /// RNA splicing /// RNA splicing","nucleic acid binding /// zinc ion binding /// RNA splicing factor activity, transesterification mechanism /// metal ion binding","intracellular /// nucleus /// spliceosome /// spliceosome /// spliceosome",null,6.2152,-1,1.2532,-2,-0.0042,0.993]
[17,36,"222001_X_AT","FAM91A2","family with sequence similarity 91, member A2","---","---","---","---","---","unknown",13.4253,-1,0,-4,0.3114,0.4967]
[17,37,"222140_S_AT","GPR89A /// GPR89B /// GPR89C","G protein-coupled receptor 89B /// G protein-coupled receptor 89A /// G protein-coupled receptor 89C","---","---","positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity","membrane /// integral to membrane",null,4.231,1,1.3244,-2,0.1492,0.7496]
[17,38,"201211_S_AT","DDX3X","DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked","---","---","---","nucleotide binding /// nucleic acid binding /// DNA binding /// RNA binding /// ATP-dependent RNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","nucleus /// cytoplasm /// cytoplasm","unknown",8.0478,-1,0.8324,0,0.0585,0.9009]
[17,39,"201328_AT","ETS2","v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)","Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","skeletal development /// regulation of transcription, DNA-dependent","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// sequence-specific DNA binding","nucleus /// nucleus","dna repair,transcription",5.1393,1,1.9398,0,0.2593,0.5744]
[17,40,"201323_AT","EBNA1BP2","EBNA1 binding protein 2","---","---","ribosome biogenesis and assembly","protein binding","membrane fraction",null,4.7922,1,0,-4,0.3911,0.3856]
[17,41,"218605_AT","TFB2M","transcription factor B2, mitochondrial","---","---","rRNA modification /// transcription /// regulation of transcription, DNA-dependent /// rRNA processing /// transcription from mitochondrial promoter","rRNA (adenine-N6,N6-)-dimethyltransferase activity /// transcription cofactor activity /// methyltransferase activity /// rRNA methyltransferase activity /// transferase activity","mitochondrion /// mitochondrial matrix","dna repair,transcription",9.735,-1,0,-4,-0.1191,0.7992]
[17,42,"204301_AT","KBTBD11","kelch repeat and BTB (POZ) domain containing 11","---","---","---","protein binding","---","unknown",6.4986,1,0,-2,-0.443,0.3195]
[17,43,"209273_S_AT","ISCA1","iron-sulfur cluster assembly 1 homolog (S. cerevisiae)","---","---","---","iron ion binding /// metal ion binding /// iron-sulfur cluster binding","mitochondrion","unknown",5.9341,1,0,0,-0.0277,0.953]
[17,44,"218004_AT","BSDC1","BSD domain containing 1","---","---","---","---","---","unknown",3.7608,1,0,-2,0.394,0.3818]
[17,45,"218882_S_AT","WDR3","WD repeat domain 3","---","---","rRNA processing","---","nucleus /// small subunit processome",null,6.6459,-1,0.8049,-2,-0.0387,0.9344]
[17,46,"202418_AT","YIF1A","Yip1 interacting factor homolog A (S. cerevisiae)","---","---","transport /// ER to Golgi vesicle-mediated transport /// protein transport","---","endoplasmic reticulum /// ER-Golgi intermediate compartment /// membrane /// integral to membrane","transport,ion channel",8.9345,-1,0,-4,0.3043,0.507]
[17,47,"221539_AT","EIF4EBP1","eukaryotic translation initiation factor 4E binding protein 1","Hypertrophy_model /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","regulation of translation /// insulin receptor signaling pathway /// negative regulation of protein biosynthetic process /// negative regulation of translational initiation","protein binding /// eukaryotic initiation factor 4E binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway",5.965,1,1.3505,-4,0.1811,0.6976]
[17,48,"203737_S_AT","PPRC1","peroxisome proliferator-activated receptor gamma, coactivator-related 1","---","---","transcription /// regulation of transcription, DNA-dependent","nucleotide binding /// nucleic acid binding /// RNA binding","---","dna repair,transcription",7.9126,-1,0.9991,0,0.3802,0.4002]
[17,49,"218001_AT","MRPS2","mitochondrial ribosomal protein S2","---","---","translation","structural constituent of ribosome","intracellular /// mitochondrion /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex",null,6.9938,1,1.2644,-2,0.1079,0.8178]
[17,50,"202510_S_AT","TNFAIP2","tumor necrosis factor, alpha-induced protein 2","---","---","angiogenesis /// multicellular organismal development /// cell differentiation","---","extracellular space","cell growth,differentiation",2.6933,-1,0.7497,-4,0.7715,0.0422]
[17,51,"217992_S_AT","EFHD2","EF-hand domain family, member D2","---","---","---","calcium ion binding","---","unknown",10.9586,-1,1.8294,0,0.5653,0.186]
[17,52,"211501_S_AT","EIF3B","eukaryotic translation initiation factor 3, subunit B","Translation_Factors /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation","nucleotide binding /// nucleic acid binding /// RNA binding /// translation initiation factor activity /// translation initiation factor activity","eukaryotic translation initiation factor 3 complex",null,9.0842,1,1.0004,0,0.5362,0.2147]
[17,53,"216607_S_AT","CYP51A1","cytochrome P450, family 51, subfamily A, polypeptide 1","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","electron transport /// steroid biosynthetic process /// cholesterol biosynthetic process /// lipid biosynthetic process /// sterol biosynthetic process","monooxygenase activity /// iron ion binding /// protein binding /// sterol 14-demethylase activity /// oxidoreductase activity /// heme binding /// metal ion binding","endoplasmic reticulum /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",5.6465,1,0,-4,0.4631,0.2953]
[]
[null,null,18]
[18,1,"218728_S_AT","CNIH4","cornichon homolog 4 (Drosophila)","---","---","intracellular signaling cascade","protein binding","endoplasmic reticulum /// membrane /// integral to membrane",null,8.9208,1,0,-2,-0.2977,0.5167]
[18,2,"210346_S_AT","CLK4","CDC-like kinase 4","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","protein amino acid phosphorylation /// peptidyl-tyrosine phosphorylation /// protein amino acid autophosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein-tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity","nucleus",null,4.4595,1,1.7599,0,-0.2906,0.5273]
[18,3,"212582_AT","OSBPL8","oxysterol binding protein-like 8","---","---","transport /// lipid transport /// steroid metabolic process","---","---","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",9.9975,1,0,-2,-0.5174,0.2343]
[18,4,"209258_S_AT","SMC3","structural maintenance of chromosomes 3","---","---","DNA metabolic process /// DNA repair /// response to DNA damage stimulus /// chromosome organization and biogenesis (sensu Eukaryota) /// cell cycle /// mitotic spindle organization and biogenesis /// chromosome segregation /// sister chromatid cohesion /// mitosis /// mitosis /// meiosis /// meiosis /// signal transduction /// DNA mediated transformation /// chromosome organization and biogenesis /// cell division","nucleotide binding /// microtubule motor activity /// protein binding /// protein binding /// ATP binding /// ATPase activity /// dynein binding /// protein heterodimerization activity","nuclear chromosome /// spindle pole /// basement membrane /// nucleus /// chromosome /// cytoplasm /// cohesin complex /// nuclear matrix","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",9.5691,1,0,-3,-0.5604,0.1907]
[18,5,"202173_S_AT","VEZF1","vascular endothelial zinc finger 1","---","---","angiogenesis /// endothelial cell development /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// cellular defense response","nucleic acid binding /// DNA binding /// specific RNA polymerase II transcription factor activity /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription",12.7379,-1,0,-3,-0.5554,0.1955]
[18,6,"212638_S_AT","WWP1","WW domain containing E3 ubiquitin protein ligase 1","---","---","protein modification process /// ubiquitin cycle /// signal transduction /// central nervous system development /// negative regulation of transcription /// protein ubiquitination /// entry of virus into host cell","ubiquitin-protein ligase activity /// ubiquitin-protein ligase activity /// protein binding /// protein binding /// ligase activity","ubiquitin ligase complex /// intracellular","dna repair,transcription:signal transduction,signaling pathway",4.6344,1,1.24,-2,0.1319,0.7781]
[18,7,"209417_S_AT","IFI35","interferon-induced protein 35","---","---","immune response /// immune response /// response to virus","protein binding","nucleus","immune response",4.1491,1,0,-2,-0.713,0.0721]
[18,8,"201921_AT","GNG10 /// LOC552891","guanine nucleotide binding protein (G protein), gamma 10 /// hypothetical protein LOC552891","G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm","signal transduction /// signal transduction /// G-protein coupled receptor protein signaling pathway","GTPase activity /// signal transducer activity /// heat shock protein binding","heterotrimeric G-protein complex /// membrane","signal transduction,signaling pathway",8.3939,1,0,-2,-0.4293,0.3364]
[18,9,"213262_AT","SACS","spastic ataxia of Charlevoix-Saguenay (sacsin)","---","---","protein folding /// protein folding /// protein modification process","ATP binding /// heat shock protein binding","---",null,6.0036,1,0,-1,0.0158,0.9731]
[18,10,"203202_AT","KRR1","KRR1, small subunit (SSU) processome component, homolog (yeast)","---","---","---","RNA binding /// protein binding /// snoRNA binding","small nucleolar ribonucleoprotein complex","unknown",7.3657,1,0,-1,-0.4811,0.2744]
[18,11,"212905_AT","CSTF2T","cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA processing","nucleotide binding /// nucleic acid binding /// RNA binding","intracellular",null,9.9614,1,1.6094,-1,-0.752,0.0512]
[18,12,"204141_AT","TUBB2A","tubulin, beta 2A","---","---","microtubule-based process /// microtubule-based movement /// protein polymerization","nucleotide binding /// GTPase activity /// structural molecule activity /// structural constituent of cytoskeleton /// protein binding /// GTP binding","cytoplasm /// cytoskeleton /// microtubule /// protein complex",null,4.3256,1,0,-2,-0.3567,0.4322]
[18,13,"209004_S_AT","FBXL5","F-box and leucine-rich repeat protein 5","---","---","ubiquitin cycle /// protein ubiquitination","ubiquitin-protein ligase activity /// protein binding","ubiquitin ligase complex",null,11.0923,1,0,-1,-0.7154,0.0707]
[18,14,"201845_S_AT","RYBP","RING1 and YY1 binding protein","---","---","negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent /// apoptosis /// multicellular organismal development","DNA binding /// transcription corepressor activity /// zinc ion binding /// metal ion binding","intracellular /// cytoplasm","dna repair,transcription:apoptosis",6.7292,1,0,-1,-0.3738,0.4087]
[18,15,"202346_AT","HIP2","huntingtin interacting protein 2","Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/physiological_process-GenMAPP/Mm_Proteasome_Degradation/Mm_Proteasome_Degradation.htm","regulation of transcription, DNA-dependent /// protein modification process /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle","transcription factor activity /// ubiquitin-protein ligase activity /// ubiquitin-protein ligase activity /// protein binding /// ligase activity /// small conjugating protein ligase activity","nucleus /// cytoplasm","dna repair,transcription",6.5852,1,0,-1,-0.2006,0.6663]
[18,16,"204521_AT","C12orf24","chromosome 12 open reading frame 24","---","---","---","---","---","unknown",11.4172,1,1.9491,-1,-0.6151,0.1415]
[18,17,"201603_AT","PPP1R12A","protein phosphatase 1, regulatory (inhibitor) subunit 12A","---","---","regulation of muscle contraction","signal transducer activity /// protein binding","cytoplasm /// actin cytoskeleton",null,8.2621,1,0,-1,-0.3967,0.3782]
[18,18,"213229_AT","DICER1","Dicer1, Dcr-1 homolog (Drosophila)","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","RNA processing /// stem cell maintenance /// lung development /// embryonic limb morphogenesis /// RNA interference, production of siRNA /// RNA interference, targeting of mRNA for destruction /// embryonic hindlimb morphogenesis /// miRNA-mediated gene silencing, production of miRNAs /// branching morphogenesis of a tube","nucleotide binding /// nucleic acid binding /// RNA binding /// double-stranded RNA binding /// double-stranded RNA binding /// helicase activity /// nuclease activity /// endonuclease activity /// ribonuclease III activity /// ribonuclease III activity /// protein binding /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","intracellular /// intracellular",null,8.6137,1,0,-2,-0.3317,0.4673]
[18,19,"201996_S_AT","SPEN","spen homolog, transcriptional regulator (Drosophila)","---","---","transcription /// regulation of transcription, DNA-dependent /// Notch signaling pathway /// regulation of transcription","nucleotide binding /// nucleic acid binding /// DNA binding /// RNA binding /// binding","nucleus","dna repair,transcription:signal transduction,signaling pathway",13.2745,1,0,0,-0.3878,0.39]
[18,20,"213701_AT","C12orf29","chromosome 12 open reading frame 29","---","---","---","---","---","unknown",9.6748,1,0,-2,-0.5729,0.1788]
[18,21,"213128_S_AT","UBE3A","ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)","---","---","protein modification process /// proteolysis /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle /// brain development","ubiquitin-protein ligase activity /// protein binding /// ligase activity","intracellular /// cytosol /// protein complex","proteolysis",9.9571,1,0,-3,-0.6807,0.0923]
[18,22,"202634_AT","POLR2K","polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa","RNA_transcription_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_RNA_transcription_Reactome/Hs_RNA_transcription_Reactome.htm","transcription /// regulation of transcription from RNA polymerase I promoter /// transcription from RNA polymerase II promoter /// transcription from RNA polymerase III promoter","DNA binding /// DNA-directed RNA polymerase activity /// zinc ion binding /// zinc ion binding /// metal ion binding","DNA-directed RNA polymerase II, core complex /// DNA-directed RNA polymerase III complex","dna repair,transcription",6.8811,1,0,-2,-0.1822,0.6958]
[18,23,"208750_S_AT","ARF1","ADP-ribosylation factor 1","---","---","transport /// ER to Golgi vesicle-mediated transport /// small GTPase mediated signal transduction /// protein transport /// vesicle-mediated transport","nucleotide binding /// GTPase activity /// receptor signaling protein activity /// protein binding /// GTP binding","intracellular /// cytosol /// plasma membrane /// endomembrane system /// sarcomere","transport,ion channel:signal transduction,signaling pathway",6.9058,1,1.3582,-3,0.0232,0.9607]
[18,24,"211960_S_AT","RAB7A","RAB7A, member RAS oncogene family","---","---","transport /// endocytosis /// small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTPase activity /// protein binding /// GTP binding","lysosome /// lysosome /// endosome /// late endosome /// late endosome /// cytoplasmic vesicle","transport,ion channel:signal transduction,signaling pathway",5.3728,1,1.3009,-3,-0.1097,0.8149]
[18,25,"202666_S_AT","ACTL6A","actin-like 6A","---","---","regulation of cell growth /// chromatin remodeling /// chromatin remodeling /// transcription /// regulation of transcription, DNA-dependent /// signal transduction /// chromatin modification","chromatin binding /// chromatin binding /// protein binding /// ATP binding","nucleus /// plasma membrane /// chromatin remodeling complex /// NuA4 histone acetyltransferase complex","dna repair,transcription:cell growth,differentiation:signal transduction,signaling pathway",11.8221,1,0,-2,-0.658,0.1081]
[18,26,"212060_AT","SR140","U2-associated SR140 protein","---","---","RNA processing","nucleotide binding /// nucleic acid binding /// RNA binding","---",null,9.1962,1,0,-2,-0.221,0.6339]
[18,27,"212709_AT","NUP160","nucleoporin 160kDa","---","---","mRNA export from nucleus /// protein targeting /// transport /// protein transport /// mRNA transport","nucleocytoplasmic transporter activity /// protein binding /// porin activity","nuclear pore /// nuclear pore /// integral to membrane /// outer membrane","transport,ion channel",8.0748,1,0,-2,-0.1558,0.7387]
[18,28,"201362_AT","IVNS1ABP","influenza virus NS1A binding protein","---","---","transcription from RNA polymerase III promoter /// RNA splicing /// response to virus","protein binding","transcription factor complex /// spliceosome /// cytoplasm /// cytoskeleton","dna repair,transcription",9.6736,1,0,-2,-0.4025,0.3706]
[18,29,"207845_S_AT","ANAPC10","anaphase promoting complex subunit 10","---","---","regulation of progression through cell cycle /// G2/M transition of mitotic cell cycle /// mitotic anaphase /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle /// cell cycle /// mitosis /// mitosis /// regulation of mitotic metaphase/anaphase transition /// cell division","ubiquitin-protein ligase activity /// protein binding /// protein binding","anaphase-promoting complex /// anaphase-promoting complex","cell cycle,proliferation",9.652,1,0,-3,-0.4919,0.2621]
[18,30,"202557_AT","STCH","stress 70 protein chaperone, microsome-associated, 60kDa","---","---","---","nucleotide binding /// ATP binding","endoplasmic reticulum /// microsome /// microsome","unknown",12.6859,1,0,-2,-0.4804,0.2752]
[18,31,"204331_S_AT","MRPS12","mitochondrial ribosomal protein S12","---","---","translation","structural constituent of ribosome /// structural constituent of ribosome /// protein binding","intracellular /// mitochondrion /// mitochondrial ribosome /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex",null,10.2206,1,0,1,-0.1299,0.7814]
[18,32,"202146_AT","IFRD1","interferon-related developmental regulator 1","Hypertrophy_model","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm","multicellular organismal development /// myoblast cell fate determination /// adult somatic muscle development /// cell differentiation /// muscle cell differentiation","---","nucleus","cell growth,differentiation",10.7139,1,0,-2,-0.2668,0.563]
[18,33,"213581_AT","PDCD2","programmed cell death 2","---","---","apoptosis /// apoptosis","DNA binding /// protein binding /// zinc ion binding /// metal ion binding","cytoplasm","apoptosis",9.0054,1,0,-2,-0.3868,0.3914]
[18,34,"213939_S_AT","RUFY3","RUN and FYVE domain containing 3","---","---","multicellular organismal development /// nervous system development /// cell differentiation","---","cell projection","cell growth,differentiation",15.036,1,0,0,-0.8709,0.0107]
[18,35,"202163_S_AT","CNOT8","CCR4-NOT transcription complex, subunit 8","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// negative regulation of cell proliferation","transcription factor activity /// transcription factor activity","intracellular /// nucleus /// nucleus /// nucleus /// cytoplasm","dna repair,transcription:cell cycle,proliferation",10.3974,1,1.4299,-3,-0.6515,0.1129]
[18,36,"208671_AT","SERINC1","serine incorporator 1","---","---","phosphatidylserine metabolic process /// sphingolipid metabolic process /// L-serine transport /// positive regulation of transferase activity","protein binding /// L-serine transmembrane transporter activity","endoplasmic reticulum membrane /// plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",6.0177,1,1.5059,0,-0.1597,0.7323]
[18,37,"213452_AT","ZNF184","zinc finger protein 184","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// DNA binding /// zinc ion binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus /// nucleus","dna repair,transcription",10.7251,1,0,-2,-0.6058,0.1493]
[18,38,"212267_AT","WAPAL","wings apart-like homolog (Drosophila)","---","---","---","protein binding","---","unknown",10.0948,1,0,-1,-0.4564,0.3033]
[18,39,"201437_S_AT","EIF4E","eukaryotic translation initiation factor 4E","Hypertrophy_model /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// regulation of translation","RNA cap binding /// RNA binding /// translation initiation factor activity /// translation initiation factor activity /// translation initiation factor activity /// protein binding","cytoplasm /// eukaryotic translation initiation factor 4F complex",null,13.8516,1,0,-2,-0.5408,0.2101]
[18,40,"219777_AT","GIMAP6","GTPase, IMAP family member 6","---","---","---","GTP binding","---","unknown",9.9665,1,0,-2,-0.7475,0.0534]
[18,41,"212920_AT","---","---","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// negative regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// chromatin binding /// protein binding /// zinc ion binding /// transcription repressor activity /// transcription repressor activity /// transcription repressor activity /// metal ion binding","intracellular /// nucleus /// nucleus","dna repair,transcription",13.117,1,1.2697,0,-0.4509,0.3099]
[18,42,"219037_AT","RRP15","ribosomal RNA processing 15 homolog (S. cerevisiae)","---","---","---","protein binding","---","unknown",7.104,1,0,-2,0.0728,0.8768]
[18,43,"203819_S_AT","IGF2BP3","insulin-like growth factor 2 mRNA binding protein 3","---","---","RNA processing /// translation /// regulation of translation /// anatomical structure morphogenesis","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding","cytoplasm /// cytoplasm",null,11.303,1,0,-2,-0.7849,0.0366]
[18,44,"209358_AT","TAF11","TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription","RNA polymerase II transcription factor activity /// protein binding /// protein binding /// general RNA polymerase II transcription factor activity","nucleus /// transcription factor TFIID complex /// transcription factor TFIID complex","dna repair,transcription",9.9347,1,0,-1,-0.4392,0.3242]
[18,45,"209666_S_AT","CHUK","conserved helix-loop-helix ubiquitous kinase","Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","morphogenesis of an epithelial sheet /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// immune response /// I-kappaB phosphorylation /// anatomical structure morphogenesis /// osteoclast differentiation /// odontogenesis (sensu Vertebrata)","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// IkappaB kinase activity /// kinase activity /// transferase activity","cytoplasm /// cytoplasm /// endoplasmic reticulum /// membrane","cell growth,differentiation:immune response",8.0683,1,1.9046,-2,-0.3627,0.4239]
[18,46,"208802_AT","SRP72","signal recognition particle 72kDa","---","---","protein amino acid phosphorylation /// SRP-dependent cotranslational protein targeting to membrane /// signal transduction","signal transducer activity /// binding /// 7S RNA binding /// kinase activity","cytoplasm /// signal recognition particle, endoplasmic reticulum targeting /// ribonucleoprotein complex /// signal recognition particle","signal transduction,signaling pathway",14.3631,1,0,-3,-0.6259,0.1327]
[18,47,"201689_S_AT","TPD52","tumor protein D52","---","---","anatomical structure morphogenesis /// B cell differentiation /// secretion","calcium ion binding /// protein binding /// identical protein binding /// protein homodimerization activity /// protein heterodimerization activity","cytoplasm /// endoplasmic reticulum /// perinuclear region of cytoplasm","cell growth,differentiation",15.3865,1,0,-2,-0.4606,0.2982]
[18,48,"203885_AT","RAB21","RAB21, member RAS oncogene family","---","---","transport /// small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTP binding","endosome /// membrane","transport,ion channel:signal transduction,signaling pathway",9.4771,1,0,0,-0.2639,0.5674]
[18,49,"217989_AT","HSD17B11","hydroxysteroid (17-beta) dehydrogenase 11","---","---","steroid biosynthetic process /// metabolic process /// lipid biosynthetic process","oxidoreductase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",12.5033,1,0,-2,-0.8323,0.0202]
[18,50,"221727_AT","SUB1","SUB1 homolog (S. cerevisiae)","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter","DNA binding /// single-stranded DNA binding /// transcription coactivator activity /// transcription coactivator activity /// protein binding","transcription factor complex","dna repair,transcription",11.1089,1,1.3382,-3,-0.2817,0.5405]
[18,51,"202664_AT","WIPF1","WAS/WASL interacting protein family, member 1","---","---","protein complex assembly /// actin polymerization and/or depolymerization /// actin filament-based movement","actin binding /// actin binding /// protein binding /// profilin binding","cytoplasm /// cytoskeleton /// actin cytoskeleton /// cytoplasmic vesicle",null,12.4538,1,0,-2,-0.821,0.0236]
[18,52,"208896_AT","DDX18","DEAD (Asp-Glu-Ala-Asp) box polypeptide 18","---","---","---","nucleotide binding /// nucleic acid binding /// RNA binding /// ATP-dependent RNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","---","unknown",12.2466,1,0,-3,-0.142,0.7613]
[18,53,"204286_S_AT","PMAIP1","phorbol-12-myristate-13-acetate-induced protein 1","---","---","release of cytochrome c from mitochondria /// induction of apoptosis /// caspase activation /// cell structure disassembly during apoptosis /// virus-infected cell apoptosis /// response to dsRNA","protein binding","mitochondrion","apoptosis",9.8827,1,0,-3,0.1033,0.8256]
[]
[null,null,19]
[19,1,"213008_AT","FANCI","Fanconi anemia, complementation group I","---","---","DNA repair /// response to DNA damage stimulus /// cell cycle","protein binding","chromosome","dna repair,transcription:cell cycle,proliferation",0.595,1,1.5594,3,0.2154,0.6427]
[19,2,"206792_X_AT","PDE4C","phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)","G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm","signal transduction","catalytic activity /// cyclic-nucleotide phosphodiesterase activity /// 3',5'-cyclic-nucleotide phosphodiesterase activity /// 3',5'-cyclic-nucleotide phosphodiesterase activity /// 3',5'-cyclic-AMP phosphodiesterase activity /// hydrolase activity","---","signal transduction,signaling pathway",1.7234,1,0,3,-0.4213,0.3465]
[19,3,"201010_S_AT","TXNIP","thioredoxin interacting protein","---","---","keratinocyte differentiation","protein binding","cytoplasm /// cytoplasm","cell growth,differentiation",0.8786,1,0.0002,1,0.0699,0.8816]
[19,4,"209974_S_AT","BUB3","BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","mitosis /// mitotic cell cycle checkpoint /// mitotic cell cycle spindle assembly checkpoint /// cell proliferation","protein binding","kinetochore","cell cycle,proliferation",1.5724,-1,0.0002,3,-0.8857,0.008]
[19,5,"38447_AT","ANKRD13D","ankyrin repeat domain 13 family, member D","---","---","---","---","---","unknown",1.6348,1,0,3,0.2492,0.5899]
[19,6,"208149_X_AT","DDX11","DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)","---","---","mitotic sister chromatid segregation /// regulation of progression through cell cycle /// S phase of mitotic cell cycle /// G2/M transition of mitotic cell cycle /// nucleobase, nucleoside, nucleotide and nucleic acid metabolic process /// cell cycle /// positive regulation of cell proliferation","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA helicase activity /// RNA binding /// ATP-dependent DNA helicase activity /// helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides","nucleus /// nucleolus","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",0.3408,1,0.1458,3,0.6388,0.1225]
[19,7,"201663_S_AT","SMC4","structural maintenance of chromosomes 4","---","---","mitotic sister chromatid segregation /// DNA metabolic process /// chromosome organization and biogenesis (sensu Eukaryota) /// cell cycle /// mitosis /// mitotic chromosome condensation /// mitotic chromosome condensation /// chromosome organization and biogenesis /// cell division","nucleotide binding /// protein binding /// ATP binding /// ATP binding /// protein heterodimerization activity","condensin complex /// nucleus /// chromosome /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",1.2648,1,0,5,-0.4098,0.3612]
[19,8,"218764_AT","PRKCH","protein kinase C, eta","Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells /// G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// Smooth_muscle_contraction /// Smooth_muscle_contraction /// Smooth_muscle_contraction /// Wnt_signaling /// Wnt_signaling /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","protein amino acid phosphorylation /// protein amino acid phosphorylation /// signal transduction /// intracellular signaling cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein kinase C activity /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding","---","signal transduction,signaling pathway",2.4212,-1,0,3,-0.6827,0.091]
[19,9,"202605_AT","GUSB","glucuronidase, beta","---","---","carbohydrate metabolic process /// carbohydrate metabolic process /// glycosaminoglycan catabolic process /// metabolic process /// glycosaminoglycan metabolic process","catalytic activity /// hydrolase activity, hydrolyzing O-glycosyl compounds /// beta-glucuronidase activity /// beta-glucuronidase activity /// hydrolase activity /// hydrolase activity, acting on glycosyl bonds /// cation binding","lysosome","biosynthesis,metabolism,metabolic process,biosynthetic process",0.1933,1,0.6384,5,0.146,0.7547]
[19,10,"220449_AT","MGC5566","hypothetical protein MGC5566","---","---","---","---","---","unknown",1.3345,1,0,1,-0.2236,0.6298]
[19,11,"219590_X_AT","DPH5","DPH5 homolog (S. cerevisiae)","---","---","metabolic process /// peptidyl-diphthamide biosynthetic process from peptidyl-histidine","diphthine synthase activity /// methyltransferase activity /// transferase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",0.5952,1,0.6792,5,-0.0994,0.832]
[19,12,"396_F_AT","EPOR","erythropoietin receptor","---","---","signal transduction /// signal transduction /// small GTPase mediated signal transduction","receptor activity /// transmembrane receptor activity /// hematopoietin/interferon-class (D200-domain) cytokine receptor activity /// erythropoietin receptor activity /// erythropoietin receptor activity /// guanyl-nucleotide exchange factor activity /// protein binding","intracellular /// integral to plasma membrane /// membrane /// integral to membrane","signal transduction,signaling pathway",1.3068,1,1.7213,3,0.3703,0.4135]
[19,13,"212185_X_AT","MT2A","metallothionein 2A","---","---","cellular copper ion homeostasis","copper ion binding /// protein binding /// zinc ion binding /// metal ion binding","---",null,1.0698,1,0,0,-0.3508,0.4404]
[19,14,"201717_AT","MRPL49","mitochondrial ribosomal protein L49","---","---","translation","structural constituent of ribosome","intracellular /// mitochondrion /// ribosome /// ribonucleoprotein complex",null,0.2202,1,0,0,0.8739,0.0101]
[19,15,"204825_AT","MELK","maternal embryonic leucine zipper kinase","---","---","protein amino acid phosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity","cytoplasm",null,1.5416,1,0,0,-0.4584,0.301]
[19,16,"208120_X_AT","FKSG49 /// LOC730444","FKSG49 /// hypothetical protein LOC730444","---","---","---","---","---","unknown",0.5902,1,0.8027,0,0.2434,0.5989]
[19,17,"204951_AT","RHOH","ras homolog gene family, member H","---","---","small GTPase mediated signal transduction /// T cell differentiation /// negative regulation of I-kappaB kinase/NF-kappaB cascade /// regulation of transcription","nucleotide binding /// GTPase inhibitor activity /// protein binding /// GTP binding /// GTP binding /// Rho GTPase binding /// kinase inhibitor activity","intracellular /// cytoplasm /// membrane","dna repair,transcription:cell growth,differentiation:signal transduction,signaling pathway",1.9783,1,0,0,-0.8423,0.0174]
[19,18,"33132_AT","CPSF1","cleavage and polyadenylation specific factor 1, 160kDa","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA polyadenylation /// mRNA cleavage /// mRNA processing","nucleic acid binding /// RNA binding /// mRNA 3'-UTR binding /// protein binding","nucleus /// mRNA cleavage and polyadenylation specificity factor complex",null,0.3022,1,1.0721,0,0.531,0.2201]
[19,19,"202095_S_AT","BIRC5","baculoviral IAP repeat-containing 5 (survivin)","Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","G2/M transition of mitotic cell cycle /// cytokinesis /// apoptosis /// anti-apoptosis /// anti-apoptosis /// cell cycle /// mitosis /// protein complex localization /// protein complex localization /// positive regulation of exit from mitosis /// spindle checkpoint /// negative regulation of caspase activity /// positive regulation of progression through mitotic cell cycle /// cell division /// cell division /// establishment of chromosome localization","endopeptidase inhibitor activity /// cysteine protease inhibitor activity /// protein binding /// protein binding /// microtubule binding /// zinc ion binding /// zinc ion binding /// tubulin binding /// identical protein binding /// protein homodimerization activity /// caspase inhibitor activity /// metal ion binding /// protein heterodimerization activity /// cofactor binding","chromosome, pericentric region /// chromosome, pericentric region /// chromosome, pericentric region /// intracellular /// chromosome /// cytoplasm /// cytoplasm /// cytoplasm /// centriole /// cytosol /// spindle microtubule /// cytoplasmic microtubule /// midbody /// midbody /// interphase microtubule organizing center /// protein complex /// protein complex","apoptosis:cell cycle,proliferation",2.3172,-1,0,0,-0.8647,0.012]
[19,20,"203181_X_AT","SRPK2","SFRS protein kinase 2","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","spliceosome assembly /// mRNA processing /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// protein kinase cascade /// RNA splicing /// RNA splicing /// cell differentiation","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// ATP binding /// kinase activity /// transferase activity","nucleus /// cytoplasm /// cytoplasm","cell growth,differentiation",3.238,-1,0,0,-0.877,0.0095]
[19,21,"201710_AT","MYBL2","v-myb myeloblastosis viral oncogene homolog (avian)-like 2","---","---","regulation of progression through cell cycle /// transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// anti-apoptosis /// multicellular organismal development /// regulation of transcription","DNA binding /// transcription factor activity","chromatin /// nucleus","dna repair,transcription:apoptosis:cell cycle,proliferation",0.5129,1,0,0,0.809,0.0276]
[19,22,"211005_AT","LAT","linker for activation of T cells","---","---","transport /// immune response /// immune response /// signal transduction /// integrin-mediated signaling pathway /// intracellular signaling cascade /// Ras protein signal transduction /// tetracycline transport /// calcium-mediated signaling /// mast cell degranulation /// response to antibiotic /// regulation of T cell activation","SH3/SH2 adaptor activity /// transporter activity /// protein binding /// tetracycline:hydrogen antiporter activity","immunological synapse /// endoplasmic reticulum /// membrane /// integral to membrane /// integral to membrane /// lipid raft","transport,ion channel:immune response:signal transduction,signaling pathway",2.4326,1,0,0,-0.8319,0.0203]
[19,23,"205674_X_AT","FXYD2","FXYD domain containing ion transport regulator 2","Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm","transport /// transport /// ion transport /// ion transport /// potassium ion transport /// sodium ion transport","transporter activity /// ion channel activity /// ion channel activity /// sodium:potassium-exchanging ATPase activity /// potassium ion binding /// sodium ion binding","sodium:potassium-exchanging ATPase complex /// sodium:potassium-exchanging ATPase complex /// membrane /// integral to membrane","transport,ion channel",0.7918,1,0,0,-0.1412,0.7626]
[19,24,"203213_AT","CDC2","cell division cycle 2, G1 to S and G2 to M","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of progression through cell cycle /// protein amino acid phosphorylation /// anti-apoptosis /// cell cycle /// mitosis /// traversing start control point of mitotic cell cycle /// cell division","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// cyclin-dependent protein kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","nucleus /// nucleus /// spindle microtubule /// midbody","apoptosis:cell cycle,proliferation",2.7952,1,0,0,-0.8207,0.0237]
[19,25,"207434_S_AT","FXYD2","FXYD domain containing ion transport regulator 2","Calcium_regulation_in_cardiac_cells /// Calcium_regulation_in_cardiac_cells","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm","transport /// transport /// ion transport /// ion transport /// potassium ion transport /// sodium ion transport","transporter activity /// ion channel activity /// ion channel activity /// sodium:potassium-exchanging ATPase activity /// potassium ion binding /// sodium ion binding","sodium:potassium-exchanging ATPase complex /// sodium:potassium-exchanging ATPase complex /// membrane /// integral to membrane","transport,ion channel",1.0706,1,0,0,-0.0355,0.9398]
[19,26,"218740_S_AT","CDK5RAP3","CDK5 regulatory subunit associated protein 3","---","---","regulation of cyclin-dependent protein kinase activity /// brain development /// regulation of neuron differentiation","protein binding /// neuronal Cdc2-like kinase binding","---","cell growth,differentiation",0.2382,1,0.2481,0,0.0714,0.8791]
[19,27,"203408_S_AT","SATB1","SATB homeobox 1","---","---","establishment and/or maintenance of chromatin architecture /// regulation of transcription, DNA-dependent","DNA binding /// double-stranded DNA binding /// transcription factor activity /// sequence-specific DNA binding","nucleus /// nucleus","dna repair,transcription",2.3464,1,0,0,-0.79,0.0346]
[19,28,"201291_S_AT","TOP2A","topoisomerase (DNA) II alpha 170kDa","---","---","DNA metabolic process /// DNA replication /// DNA topological change /// DNA ligation /// DNA repair /// response to DNA damage stimulus /// chromosome segregation /// apoptotic chromosome condensation /// positive regulation of apoptosis /// positive regulation of viral genome replication /// positive regulation of retroviral genome replication /// phosphoinositide-mediated signaling","nucleotide binding /// DNA binding /// DNA binding /// chromatin binding /// DNA topoisomerase activity /// DNA topoisomerase (ATP-hydrolyzing) activity /// DNA topoisomerase (ATP-hydrolyzing) activity /// protein kinase C binding /// protein binding /// ATP binding /// protein C-terminus binding /// DNA-dependent ATPase activity /// drug binding /// isomerase activity /// enzyme binding /// protein homodimerization activity /// histone deacetylase binding /// ubiquitin binding /// protein heterodimerization activity","nucleus /// nucleus /// nucleoplasm /// chromosome /// chromosome /// nucleolus /// cytoplasm /// centriole /// DNA topoisomerase complex (ATP-hydrolyzing) /// viral integration complex /// protein complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:dna replication",3.3498,-1,0,0,-0.8878,0.0076]
[19,29,"213857_S_AT","CD47","CD47 molecule","---","---","cell adhesion /// cell-matrix adhesion /// integrin-mediated signaling pathway /// opsonization /// positive regulation of cell proliferation /// positive regulation of cell-cell adhesion /// positive regulation of phagocytosis /// positive regulation of T cell activation","protein binding /// protein binding","plasma membrane /// integral to plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","cell adhesion:cell cycle,proliferation:signal transduction,signaling pathway",0.9055,1,1.4622,0,-0.6639,0.1039]
[19,30,"210052_S_AT","TPX2","TPX2, microtubule-associated, homolog (Xenopus laevis)","---","---","mitosis /// cell proliferation","protein binding /// ATP binding /// GTP binding","spindle pole /// nucleus /// spindle /// microtubule cytoskeleton","cell cycle,proliferation",3.6494,-1,0,0,-0.731,0.062]
[19,31,"205967_AT","HIST1H4C","histone cluster 1, H4c","---","---","establishment and/or maintenance of chromatin architecture /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// phosphoinositide-mediated signaling","DNA binding /// DNA binding /// protein binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,2.2236,1,1.7834,0,-0.3866,0.3916]
[19,32,"201088_AT","KPNA2","karyopherin alpha 2 (RAG cohort 1, importin alpha 1)","---","---","regulation of DNA recombination /// M phase specific microtubule process /// G2 phase of mitotic cell cycle /// DNA metabolic process /// protein import into nucleus /// NLS-bearing substrate import into nucleus /// transport /// intracellular protein transport /// protein transport","binding /// protein binding /// protein binding /// nuclear localization sequence binding /// protein transporter activity","nucleus /// nucleus /// nuclear pore /// nucleoplasm /// cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:cell cycle,proliferation",2.5584,-1,0,0,-0.9385,0.0017]
[19,33,"201853_S_AT","CDC25B","cell division cycle 25 homolog B (S. pombe)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of progression through cell cycle /// M phase of mitotic cell cycle /// mitotic cell cycle /// oocyte maturation /// protein amino acid dephosphorylation /// cell cycle /// mitosis /// mitosis /// female meiosis I /// positive regulation of cell proliferation /// positive regulation of protein kinase activity /// cell division","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// protein binding /// hydrolase activity","intracellular /// intracellular","cell cycle,proliferation",2.9981,-1,0,0,-0.7383,0.0581]
[19,34,"203214_X_AT","CDC2","cell division cycle 2, G1 to S and G2 to M","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of progression through cell cycle /// protein amino acid phosphorylation /// anti-apoptosis /// cell cycle /// mitosis /// traversing start control point of mitotic cell cycle /// cell division","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// cyclin-dependent protein kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","nucleus /// nucleus /// spindle microtubule /// midbody","apoptosis:cell cycle,proliferation",0.6748,1,1.7742,0,-0.5441,0.2068]
[19,35,"218167_AT","AMZ2","archaemetzincins-2","---","---","proteolysis","peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// metal ion binding","---","proteolysis",0.5655,1,0,0,0.4658,0.2922]
[19,36,"210559_S_AT","CDC2","cell division cycle 2, G1 to S and G2 to M","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of progression through cell cycle /// protein amino acid phosphorylation /// anti-apoptosis /// cell cycle /// mitosis /// traversing start control point of mitotic cell cycle /// cell division","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// cyclin-dependent protein kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","nucleus /// nucleus /// spindle microtubule /// midbody","apoptosis:cell cycle,proliferation",0.7559,1,1.2407,0,-0.5227,0.2288]
[19,37,"218248_AT","FAM111A","family with sequence similarity 111, member A","---","---","---","---","---","unknown",1.6412,1,0,0,-0.258,0.5764]
[19,38,"202693_S_AT","STK17A","serine/threonine kinase 17a","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// apoptosis /// induction of apoptosis /// protein kinase cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// ATP binding /// ATP binding /// kinase activity /// transferase activity","nucleus","apoptosis",0.6612,-1,1.9135,0,0.6706,0.0992]
[]
[null,null,20]
[20,1,"211899_S_AT","TRAF4","TNF receptor-associated factor 4","---","---","apoptosis /// signal transduction /// signal transduction /// multicellular organismal development /// regulation of apoptosis","DNA binding /// protein binding /// zinc ion binding /// metal ion binding","nucleus /// cytoplasm","apoptosis:signal transduction,signaling pathway",6.6837,-1,0,3,0.6004,0.154]
[20,2,"209959_AT","NR4A3","nuclear receptor subfamily 4, group A, member 3","Hypertrophy_model","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm","mesoderm formation /// transcription /// regulation of transcription, DNA-dependent","DNA binding /// DNA binding /// transcription factor activity /// steroid hormone receptor activity /// steroid hormone receptor activity /// receptor activity /// ligand-dependent nuclear receptor activity /// thyroid hormone receptor activity /// binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding","nucleus /// nucleus","dna repair,transcription",7.4271,-1,0,4,0.4892,0.2652]
[20,3,"205463_S_AT","PDGFA","platelet-derived growth factor alpha polypeptide","---","---","regulation of progression through cell cycle /// cell surface receptor linked signal transduction /// cell-cell signaling /// cell proliferation /// cell proliferation /// positive regulation of cell proliferation","platelet-derived growth factor receptor binding /// growth factor activity","extracellular space /// membrane","cell cycle,proliferation:signal transduction,signaling pathway",9.6332,-1,0.6177,3,0.447,0.3146]
[20,4,"201739_AT","SGK","serum/glucocorticoid regulated kinase","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// sodium ion transport /// apoptosis /// response to stress /// response to DNA damage stimulus","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","cytoplasm /// endoplasmic reticulum","transport,ion channel:apoptosis",9.6472,-1,0,5,0.388,0.3897]
[20,5,"204198_S_AT","RUNX3","runt-related transcription factor 3","TGF_Beta_Signaling_Pathway /// TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// induction of apoptosis /// cell proliferation /// negative regulation of progression through cell cycle /// negative regulation of epithelial cell proliferation","DNA binding /// transcription factor activity /// transcription factor activity /// protein binding /// ATP binding /// ATP binding","nucleus /// nucleus","dna repair,transcription:apoptosis:cell cycle,proliferation",9.2197,-1,0.6698,5,0.7764,0.0401]
[20,6,"205205_AT","RELB","v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)","---","---","transcription /// regulation of transcription, DNA-dependent /// antigen processing and presentation /// myeloid dendritic cell differentiation /// T-helper 1 cell differentiation /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// transcription corepressor activity /// protein binding","nucleus","dna repair,transcription:cell growth,differentiation",23.5403,1,0,4,0.7333,0.0608]
[20,7,"210538_S_AT","BIRC3","baculoviral IAP repeat-containing 3","Apoptosis /// Apoptosis_GenMAPP","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm","apoptosis /// anti-apoptosis /// anti-apoptosis /// cell surface receptor linked signal transduction /// regulation of apoptosis","ubiquitin-protein ligase activity /// protein binding /// protein binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus /// cytoplasm /// cytoplasm","apoptosis:signal transduction,signaling pathway",13.25,-1,0.8199,4,0.403,0.3701]
[20,8,"202688_AT","TNFSF10","tumor necrosis factor (ligand) superfamily, member 10","Apoptosis /// Apoptosis_GenMAPP","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm","apoptosis /// induction of apoptosis /// immune response /// signal transduction /// cell-cell signaling /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// receptor binding /// cytokine activity /// tumor necrosis factor receptor binding /// zinc ion binding /// metal ion binding","extracellular space /// soluble fraction /// integral to plasma membrane /// membrane /// integral to membrane","apoptosis:immune response:signal transduction,signaling pathway",32.776,-1,0,5,0.5268,0.2244]
[20,9,"202687_S_AT","TNFSF10","tumor necrosis factor (ligand) superfamily, member 10","Apoptosis /// Apoptosis_GenMAPP","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm","apoptosis /// induction of apoptosis /// immune response /// signal transduction /// cell-cell signaling /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// receptor binding /// cytokine activity /// tumor necrosis factor receptor binding /// zinc ion binding /// metal ion binding","extracellular space /// soluble fraction /// integral to plasma membrane /// membrane /// integral to membrane","apoptosis:immune response:signal transduction,signaling pathway",16.5717,-1,0.5318,4,0.3917,0.3849]
[]
[null,null,21]
[21,1,"210092_AT","MAGOH","mago-nashi homolog, proliferation-associated (Drosophila)","---","---","mRNA catabolic process, nonsense-mediated decay /// mRNA processing /// transport /// RNA splicing /// mRNA transport","RNA binding /// protein binding","nucleus /// nucleus /// spliceosome","transport,ion channel",1.6874,-1,0.645,0,-0.3946,0.381]
[21,2,"217915_S_AT","C15orf15","chromosome 15 open reading frame 15","---","---","translation /// ribosome biogenesis and assembly","structural constituent of ribosome","intracellular /// ribosome",null,1.224,-1,1.9217,0,0.1331,0.776]
[21,3,"221702_S_AT","TM2D3","TM2 domain containing 3","---","---","---","---","---","unknown",0.485,-1,0.6532,6,-0.4115,0.359]
[21,4,"218508_AT","DCP1A","DCP1 decapping enzyme homolog A (S. cerevisiae)","---","---","mRNA catabolic process, nonsense-mediated decay","protein binding /// hydrolase activity","cytoplasm",null,3.6753,1,0,2,0.7213,0.0673]
[21,5,"220547_S_AT","FAM35A","family with sequence similarity 35, member A","---","---","---","---","---","unknown",1.7078,-1,0,4,0.0181,0.9693]
[21,6,"201397_AT","PHGDH","phosphoglycerate dehydrogenase","---","---","L-serine biosynthetic process /// transport /// brain development /// metabolic process /// amino acid biosynthetic process","phosphoglycerate dehydrogenase activity /// phosphoglycerate dehydrogenase activity /// transporter activity /// electron carrier activity /// oxidoreductase activity /// oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor /// cofactor binding /// NAD binding","extracellular region","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",1.3962,-1,0,-2,0.1002,0.8307]
[21,7,"203138_AT","HAT1","histone acetyltransferase 1","---","---","DNA packaging /// internal protein amino acid acetylation","histone acetyltransferase activity /// histone acetyltransferase activity /// protein binding /// acyltransferase activity /// transferase activity","nucleus /// cytoplasm",null,2.8695,-1,1.1962,0,-0.2644,0.5667]
[21,8,"210213_S_AT","EIF6","eukaryotic translation initiation factor 6","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// integrin-mediated signaling pathway /// mature ribosome assembly","translation initiation factor activity /// protein binding /// ribosome binding","nucleus /// cytoplasm","signal transduction,signaling pathway",2.3989,-1,0,2,0.3691,0.4152]
[21,9,"212290_AT","SLC7A1","solute carrier family 7 (cationic amino acid transporter, y+ system), member 1","---","---","amino acid metabolic process /// transport /// transport /// amino acid transport","receptor activity /// amino acid transmembrane transporter activity /// basic amino acid transmembrane transporter activity","integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",1.9201,-1,0,0,0.0172,0.9708]
[21,10,"215416_S_AT","STOML2","stomatin (EPB72)-like 2","---","---","---","receptor binding","cytoplasm /// cytoskeleton /// cytoskeleton /// membrane","unknown",2.8871,-1,0,2,0.5201,0.2315]
[21,11,"209024_S_AT","SYNCRIP","synaptotagmin binding, cytoplasmic RNA interacting protein","---","---","RNA processing /// mRNA processing /// RNA splicing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// protein binding /// poly(A) binding","nucleus /// spliceosome /// cytoplasm /// endoplasmic reticulum /// microsome /// ribonucleoprotein complex /// ribonucleoprotein complex",null,4.2372,-1,1.2003,2,-0.3341,0.464]
[21,12,"202963_AT","RFX5","regulatory factor X, 5 (influences HLA class II expression)","---","---","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter","DNA binding /// DNA binding /// transcription factor activity /// transcription coactivator activity /// protein binding","nucleus","dna repair,transcription",3.0867,1,0,0,0.5331,0.2179]
[21,13,"209181_S_AT","RABGGTB","Rab geranylgeranyltransferase, beta subunit","---","---","protein modification process /// visual perception","catalytic activity /// prenyltransferase activity /// Rab-protein geranylgeranyltransferase activity /// protein binding /// zinc ion binding /// transferase activity /// metal ion binding","---",null,0.6572,-1,1.9136,-4,0.0617,0.8954]
[21,14,"210097_S_AT","NOL7","nucleolar protein 7, 27kDa","---","---","---","---","nucleus","unknown",1.1804,-1,1.9061,-4,-0.1123,0.8105]
[21,15,"215780_S_AT","hCG_1644608 /// LOC389168 /// SET","SET translocation (myeloid leukemia-associated) /// similar to Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (HLA-DR-associated protein II) (PHAPII) (Inhibitor of granzyme A-activated DNase) (IGAAD) /// SET translocation (myeloid leukemia-associated) pseudogene","---","---","DNA replication /// nucleosome assembly /// nucleosome assembly /// nucleosome disassembly /// nucleocytoplasmic transport /// negative regulation of histone acetylation","protein phosphatase inhibitor activity /// protein phosphatase type 2A regulator activity /// histone binding","nucleus /// nucleus /// cytoplasm /// endoplasmic reticulum /// endoplasmic reticulum /// perinuclear region of cytoplasm","transport,ion channel:dna replication",3.7988,-1,1.3374,4,-0.3642,0.4219]
[21,16,"217786_AT","PRMT5","protein arginine methyltransferase 5","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of mitosis /// cell proliferation /// chromatin modification /// peptidyl-arginine N-methylation","methyltransferase activity /// methyltransferase activity /// histone-arginine N-methyltransferase activity /// transferase activity","cytoplasm","dna repair,transcription:cell cycle,proliferation",2.1403,-1,0,2,0.4357,0.3286]
[21,17,"218140_X_AT","SRPRB","signal recognition particle receptor, B subunit","---","---","---","nucleotide binding /// receptor activity /// protein binding /// GTP binding","endoplasmic reticulum /// signal recognition particle, endoplasmic reticulum targeting /// membrane /// integral to membrane /// ribonucleoprotein complex","unknown",0.447,-1,1.6394,2,0.0962,0.8375]
[21,18,"201516_AT","SRM","spermidine synthase","Nucleotide_Metabolism","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Nucleotide_Metabolism/Hs_Nucleotide_Metabolism.htm","spermidine biosynthetic process","catalytic activity /// spermidine synthase activity /// spermidine synthase activity /// transferase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",3.171,1,0,0,0.5826,0.1698]
[21,19,"208688_X_AT","EIF3B","eukaryotic translation initiation factor 3, subunit B","Translation_Factors /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation","nucleotide binding /// nucleic acid binding /// RNA binding /// translation initiation factor activity /// translation initiation factor activity","eukaryotic translation initiation factor 3 complex",null,1.7169,-1,0,2,0.5841,0.1685]
[21,20,"201574_AT","ETF1","eukaryotic translation termination factor 1","Translation_Factors /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational termination /// regulation of translational termination","RNA binding /// translation release factor activity /// protein binding /// translation termination factor activity /// translation release factor activity, codon specific /// ribosome binding","cytoplasm /// cytoplasm",null,1.4263,-1,0,0,0.056,0.9051]
[21,21,"218499_AT","RP6-213H19.1","serine/threonine protein kinase MST4","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// apoptosis /// regulation of apoptosis","nucleotide binding /// magnesium ion binding /// magnesium ion binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein-tyrosine kinase activity /// protein binding /// ATP binding /// ATP binding /// kinase activity /// transferase activity /// identical protein binding /// metal ion binding","cytoplasm /// Golgi apparatus","apoptosis",0.8586,-1,1.3299,2,-0.5911,0.1622]
[21,22,"203712_AT","KIAA0020","KIAA0020","---","---","---","RNA binding /// binding","endoplasmic reticulum","unknown",3.5976,-1,0,2,0.4834,0.2718]
[21,23,"218625_AT","NRN1","neuritin 1","---","---","---","GPI anchor binding","membrane","unknown",1.8743,1,0,2,-0.4647,0.2934]
[21,24,"200662_S_AT","TOMM20","translocase of outer mitochondrial membrane 20 homolog (yeast)","---","---","protein targeting /// protein targeting to mitochondrion /// transport /// intracellular protein transport /// protein transport /// protein import into mitochondrion","protein binding /// protein transmembrane transporter activity /// protein transmembrane transporter activity /// unfolded protein binding","mitochondrion /// mitochondrial outer membrane translocase complex /// mitochondrial outer membrane translocase complex /// mitochondrial outer membrane translocase complex /// membrane /// integral to membrane /// outer membrane","transport,ion channel",2.1676,-1,0,6,-0.0638,0.892]
[21,25,"218870_AT","ARHGAP15","Rho GTPase activating protein 15","---","---","signal transduction /// regulation of cell shape","protein binding /// Rac GTPase activator activity","intracellular","signal transduction,signaling pathway",0.4526,-1,1.1353,2,-0.6821,0.0914]
[21,26,"212037_AT","PNN","pinin, desmosome associated protein","---","---","transcription /// regulation of transcription, DNA-dependent /// mRNA processing /// cell cycle /// cell adhesion /// RNA splicing /// negative regulation of progression through cell cycle","DNA binding /// structural molecule activity /// protein binding","spliceosome /// cytoplasm /// intermediate filament /// plasma membrane /// intercellular junction /// nuclear speck /// cell junction","dna repair,transcription:cell adhesion:cell cycle,proliferation",0.784,-1,1.545,0,-0.1922,0.6796]
[21,27,"217809_AT","BZW2","basic leucine zipper and W2 domains 2","---","---","regulation of translational initiation /// multicellular organismal development /// nervous system development /// cell differentiation","translation initiation factor activity /// protein binding","---","cell growth,differentiation",3.1231,1,0,0,0.4812,0.2743]
[21,28,"201331_S_AT","STAT6","signal transducer and activator of transcription 6, interleukin-4 induced","---","---","negative regulation of T-helper 2 type immune response /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// signal transduction /// signal transduction /// intracellular signaling cascade /// regulation of cell proliferation /// positive regulation of transcription from RNA polymerase II promoter /// positive regulation of isotype switching to IgE isotypes","DNA binding /// transcription factor activity /// transcription factor activity /// signal transducer activity /// calcium ion binding /// protein binding /// sequence-specific DNA binding","nucleus /// cytoplasm","dna repair,transcription:cell cycle,proliferation:immune response:signal transduction,signaling pathway",3.29,1,0,6,0.8316,0.0204]
[21,29,"201222_S_AT","RAD23B","RAD23 homolog B (S. cerevisiae)","---","---","DNA repair /// nucleotide-excision repair /// nucleotide-excision repair /// protein modification process /// ubiquitin cycle /// response to DNA damage stimulus","single-stranded DNA binding /// protein binding","nucleus /// nucleus /// cytoplasm /// cytosol /// protein complex","dna repair,transcription",0.7108,-1,1.3328,4,-0.6191,0.1383]
[21,30,"200075_S_AT","GUK1","guanylate kinase 1","---","---","GTP biosynthetic process","nucleotide binding /// guanylate kinase activity /// guanylate kinase activity /// ATP binding /// drug binding /// kinase activity /// transferase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",1.8114,-1,1.6517,-4,-0.1704,0.7149]
[21,31,"212186_AT","ACACA","acetyl-Coenzyme A carboxylase alpha","Fatty_Acid_Synthesis /// Fatty_Acid_Synthesis /// Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","fatty acid biosynthetic process /// metabolic process /// lipid biosynthetic process","nucleotide binding /// catalytic activity /// acetyl-CoA carboxylase activity /// acetyl-CoA carboxylase activity /// biotin carboxylase activity /// protein binding /// ATP binding /// biotin binding /// ligase activity /// manganese ion binding /// metal ion binding","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",2.3452,1,0,2,0.4712,0.2858]
[21,32,"201755_AT","MCM5","minichromosome maintenance complex component 5","Cell_cycle_KEGG /// DNA_replication_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// DNA replication /// DNA replication /// DNA replication initiation /// transcription /// regulation of transcription, DNA-dependent","nucleotide binding /// DNA binding /// protein binding /// ATP binding /// DNA-dependent ATPase activity","nucleus /// nucleus","dna repair,transcription:cell cycle,proliferation:dna replication",4.086,1,0,4,0.6926,0.0846]
[21,33,"218205_S_AT","MKNK2","MAP kinase interacting serine/threonine kinase 2","---","---","regulation of translation /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// cell surface receptor linked signal transduction /// protein kinase cascade","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// myosin light chain kinase activity /// ATP binding /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// metal ion binding","---","signal transduction,signaling pathway",3.6761,-1,0,4,0.1338,0.7749]
[21,34,"209786_AT","HMGN4","high mobility group nucleosomal binding domain 4","---","---","---","DNA binding","chromatin /// nucleus","unknown",2.3802,-1,1.0546,4,-0.7378,0.0584]
[21,35,"218708_AT","NXT1","NTF2-like export factor 1","---","---","RNA export from nucleus /// protein export from nucleus /// transport /// protein transport","protein binding /// Ran GTPase binding","intracellular /// nuclear pore /// nuclear pore /// cytoplasm /// cytoplasm","transport,ion channel",3.3559,1,0,4,0.3664,0.4189]
[21,36,"204905_S_AT","EEF1E1","eukaryotic translation elongation factor 1 epsilon 1","---","---","translation /// negative regulation of cell proliferation /// negative regulation of cell proliferation /// positive regulation of apoptosis /// positive regulation of apoptosis /// positive regulation of DNA damage response, signal transduction by p53 class mediator /// positive regulation of DNA damage response, signal transduction by p53 class mediator","protein binding /// protein binding","nucleus /// nucleus /// cytoplasm /// cytoplasm","apoptosis:cell cycle,proliferation:signal transduction,signaling pathway",1.7318,-1,0,0,-0.143,0.7598]
[21,37,"202208_S_AT","ARL4C","ADP-ribosylation factor-like 4C","---","---","small GTPase mediated signal transduction","nucleotide binding /// GTPase activity /// GTP binding","intracellular /// nucleus","signal transduction,signaling pathway",1.0128,-1,1.256,6,-0.0907,0.8467]
[21,38,"217833_AT","SYNCRIP","synaptotagmin binding, cytoplasmic RNA interacting protein","---","---","RNA processing /// mRNA processing /// RNA splicing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// protein binding /// poly(A) binding","nucleus /// spliceosome /// cytoplasm /// endoplasmic reticulum /// microsome /// ribonucleoprotein complex /// ribonucleoprotein complex",null,1.8335,-1,0,-2,0.0827,0.8601]
[21,39,"204178_S_AT","RBM14","RNA binding motif protein 14","---","---","DNA replication /// DNA repair /// DNA recombination /// transcription /// regulation of transcription, DNA-dependent /// response to hormone stimulus /// histone deacetylation /// estrogen receptor signaling pathway /// glucocorticoid receptor signaling pathway /// positive regulation of transcription from RNA polymerase II promoter","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// RNA polymerase II transcription mediator activity /// ligand-dependent nuclear receptor transcription coactivator activity /// protein binding, bridging","mediator complex /// transcription factor complex /// ribonucleoprotein complex","dna repair,transcription:dna replication:signal transduction,signaling pathway",3.0801,1,0,2,0.8619,0.0126]
[21,40,"214022_S_AT","IFITM1","interferon induced transmembrane protein 1 (9-27)","---","---","regulation of progression through cell cycle /// immune response /// cell surface receptor linked signal transduction /// negative regulation of cell proliferation /// response to biotic stimulus","receptor signaling protein activity /// protein binding","plasma membrane /// membrane /// integral to membrane","cell cycle,proliferation:immune response:signal transduction,signaling pathway",0.5422,-1,0.1939,0,-0.6534,0.1115]
[21,41,"217716_S_AT","SEC61A1","Sec61 alpha 1 subunit (S. cerevisiae)","---","---","protein targeting /// transport /// protein secretion /// protein transport","protein binding /// protein transmembrane transporter activity","endoplasmic reticulum /// membrane /// integral to membrane","transport,ion channel",1.7857,1,0,4,0.9787,0.0001]
[21,42,"203298_S_AT","JARID2","jumonji, AT rich interactive domain 2","---","---","negative regulation of transcription from RNA polymerase II promoter /// liver development /// transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development /// central nervous system development /// negative regulation of cell proliferation /// regulation of cell proliferation /// negative regulation of transcription, DNA-dependent /// spleen development /// thymus development","DNA binding /// protein binding /// transcription repressor activity","intracellular /// nucleus","dna repair,transcription:cell cycle,proliferation",0.6196,-1,1.8249,2,-0.0394,0.9332]
[21,43,"200732_S_AT","PTP4A1","protein tyrosine phosphatase type IVA, member 1","---","---","protein amino acid dephosphorylation /// cell cycle /// multicellular organismal development /// dephosphorylation","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// hydrolase activity /// phosphoric monoester hydrolase activity","cytoplasm /// endosome /// endoplasmic reticulum /// membrane","cell cycle,proliferation",3.1373,1,0,6,0.8462,0.0164]
[21,44,"201690_S_AT","TPD52","tumor protein D52","---","---","anatomical structure morphogenesis /// B cell differentiation /// secretion","calcium ion binding /// protein binding /// identical protein binding /// protein homodimerization activity /// protein heterodimerization activity","cytoplasm /// endoplasmic reticulum /// perinuclear region of cytoplasm","cell growth,differentiation",0.9861,-1,0,-2,-0.0458,0.9223]
[21,45,"203462_X_AT","EIF3B","eukaryotic translation initiation factor 3, subunit B","Translation_Factors /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation","nucleotide binding /// nucleic acid binding /// RNA binding /// translation initiation factor activity /// translation initiation factor activity","eukaryotic translation initiation factor 3 complex",null,3.2363,1,0,2,0.6477,0.1157]
[21,46,"202245_AT","LSS","lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)","Cholesterol_Biosynthesis /// Cholesterol_Biosynthesis /// Cholesterol_Biosynthesis /// Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","steroid biosynthetic process /// metabolic process /// steroid metabolic process /// lipid biosynthetic process","lanosterol synthase activity /// lanosterol synthase activity /// catalytic activity /// lyase activity /// isomerase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",3.575,1,0,2,0.5209,0.2306]
[21,47,"211967_AT","TMEM123","transmembrane protein 123","---","---","---","receptor activity","membrane /// integral to membrane","unknown",2.0766,-1,1.6832,6,-0.3681,0.4166]
[21,48,"201601_X_AT","IFITM1","interferon induced transmembrane protein 1 (9-27)","---","---","regulation of progression through cell cycle /// immune response /// cell surface receptor linked signal transduction /// negative regulation of cell proliferation /// response to biotic stimulus","receptor signaling protein activity /// protein binding","plasma membrane /// membrane /// integral to membrane","cell cycle,proliferation:immune response:signal transduction,signaling pathway",0.7201,-1,0,6,-0.6648,0.1032]
[21,49,"202022_AT","ALDOC","aldolase C, fructose-bisphosphate","Glycolysis_and_Gluconeogenesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm","fructose metabolic process /// glycolysis /// metabolic process","catalytic activity /// fructose-bisphosphate aldolase activity /// fructose-bisphosphate aldolase activity /// lyase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",3.3569,-1,0,0,0.1815,0.6969]
[21,50,"203259_S_AT","HDDC2","HD domain containing 2","---","---","---","catalytic activity","---","unknown",2.4849,-1,0,4,0.0404,0.9315]
[21,51,"209083_AT","CORO1A","coronin, actin binding protein, 1A","---","---","transport /// cell motility /// mitosis","actin binding /// structural molecule activity /// protein binding","cytoplasm /// lysosomal membrane /// cytoskeleton /// actin cytoskeleton /// membrane /// cytoplasmic vesicle","transport,ion channel",2.8759,-1,0,2,0.1073,0.8189]
[21,52,"216396_S_AT","EI24","etoposide induced 2.4 mRNA","---","---","induction of apoptosis","---","---","apoptosis",4.765,1,0,6,0.8026,0.0298]
[21,53,"202068_S_AT","LDLR","low density lipoprotein receptor (familial hypercholesterolemia)","Statin_Pathway_PharmGKB /// Statin_Pathway_PharmGKB /// Wnt_signaling /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","protein amino acid O-linked glycosylation /// lipid metabolic process /// lipid metabolic process /// transport /// lipid transport /// endocytosis /// endocytosis /// steroid metabolic process /// cholesterol metabolic process /// cholesterol absorption /// cholesterol transport /// lipoprotein metabolic process /// cholesterol homeostasis","receptor activity /// transmembrane receptor activity /// low-density lipoprotein receptor activity /// low-density lipoprotein receptor activity /// lipid transporter activity /// calcium ion binding /// protein binding /// protein binding /// lipoprotein binding","endosome /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",5.6507,1,0,0,0.2969,0.5179]
[]
[null,null,22]
[22,1,"213649_AT","SFRS7","splicing factor, arginine/serine-rich 7, 35kDa","mRNA_processing_Reactome /// mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA processing /// mRNA processing /// RNA splicing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// protein binding /// zinc ion binding /// metal ion binding","nucleus",null,2.0865,1,0,6,-0.4384,0.3252]
[22,2,"46256_AT","SPSB3","splA/ryanodine receptor domain and SOCS box containing 3","---","---","intracellular signaling cascade","---","---",null,1.0854,1,0,0,0.0858,0.8549]
[22,3,"218115_AT","ASF1B","ASF1 anti-silencing function 1 homolog B (S. cerevisiae)","---","---","chromatin assembly or disassembly /// nucleosome assembly /// transcription /// regulation of transcription, DNA-dependent /// protein folding /// multicellular organismal development /// spermatogenesis /// chromatin modification /// cell differentiation","histone binding","chromatin /// nucleus","dna repair,transcription:cell growth,differentiation",1.0202,1,0,-2,0.2747,0.551]
[22,4,"201476_S_AT","RRM1","ribonucleotide reductase M1 polypeptide","Nucleotide_Metabolism","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Nucleotide_Metabolism/Hs_Nucleotide_Metabolism.htm","DNA replication /// DNA replication","nucleotide binding /// catalytic activity /// ribonucleoside-diphosphate reductase activity /// ribonucleoside-diphosphate reductase activity /// ATP binding /// oxidoreductase activity","cytoplasm /// ribonucleoside-diphosphate reductase complex /// ribonucleoside-diphosphate reductase complex","dna replication",0.2046,1,0.7598,0,0.3134,0.4937]
[22,5,"202466_AT","POLS","polymerase (DNA directed) sigma","---","---","DNA replication /// double-strand break repair /// cell cycle /// sister chromatid cohesion /// mitosis /// mitotic chromosome condensation /// response to drug /// cell division","DNA binding /// DNA-directed DNA polymerase activity /// transferase activity /// nucleotidyltransferase activity /// SMC protein binding","nucleus","cell cycle,proliferation:dna replication",2.8305,1,0,2,-0.6615,0.1056]
[22,6,"45749_AT","FAM65A","family with sequence similarity 65, member A","---","---","---","binding","---","unknown",1.0746,1,0.8255,2,0.1747,0.708]
[22,7,"201639_S_AT","CPSF1","cleavage and polyadenylation specific factor 1, 160kDa","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","mRNA polyadenylation /// mRNA cleavage /// mRNA processing","nucleic acid binding /// RNA binding /// mRNA 3'-UTR binding /// protein binding","nucleus /// mRNA cleavage and polyadenylation specificity factor complex",null,0.964,1,0.0004,2,0.5544,0.1965]
[22,8,"212371_AT","C1orf121","chromosome 1 open reading frame 121","---","---","---","---","---","unknown",1.2286,1,0,0,0.8068,0.0283]
[22,9,"212022_S_AT","MKI67","antigen identified by monoclonal antibody Ki-67","---","---","regulation of progression through cell cycle /// cell cycle /// cell proliferation","nucleotide binding /// protein binding /// ATP binding","nucleolus","cell cycle,proliferation",3.2951,-1,0,6,-0.897,0.0062]
[22,10,"205548_S_AT","BTG3","BTG family, member 3","---","---","regulation of progression through cell cycle /// negative regulation of cell proliferation /// negative regulation of progression through mitotic cell cycle","---","cytoplasm","cell cycle,proliferation",1.3042,1,0.5375,0,0.7656,0.0448]
[22,11,"209075_S_AT","ISCU","iron-sulfur cluster scaffold homolog (E. coli)","---","---","nitrogen fixation /// iron-sulfur cluster assembly /// iron-sulfur cluster assembly","iron ion binding /// iron ion binding /// protein binding /// metal ion binding /// iron-sulfur cluster binding","cytoplasm /// cytoplasm /// mitochondrion /// mitochondrion",null,2.1082,1,0,2,0.4755,0.2808]
[22,12,"218857_S_AT","ASRGL1","asparaginase like 1","---","---","glycoprotein catabolic process","asparaginase activity","---",null,1.1345,1,0,4,-0.2082,0.6542]
[22,13,"36129_AT","SGSM2","small G protein signaling modulator 2","---","---","regulation of Rab GTPase activity","Rab GTPase activator activity","intracellular",null,0.9682,1,0,4,0.2487,0.5907]
[22,14,"202580_X_AT","FOXM1","forkhead box M1","---","---","transcription /// regulation of transcription, DNA-dependent","DNA binding /// transcription factor activity /// protein binding /// sequence-specific DNA binding","nucleus","dna repair,transcription",0.9156,1,0.7248,0,-0.1935,0.6776]
[22,15,"62987_R_AT","CACNG4","calcium channel, voltage-dependent, gamma subunit 4","---","---","transport /// transport /// ion transport /// calcium ion transport","structural molecule activity /// ion channel activity /// voltage-gated ion channel activity /// voltage-gated calcium channel activity /// voltage-gated calcium channel activity /// calcium channel activity /// calcium ion binding","integral to plasma membrane /// tight junction /// membrane /// integral to membrane","transport,ion channel",1.7512,1,1.9581,0,0.2812,0.5413]
[22,16,"218009_S_AT","PRC1","protein regulator of cytokinesis 1","---","---","mitotic spindle elongation /// cytokinesis /// cell cycle /// cell division","protein binding","nucleus /// cytoplasm /// microtubule /// spindle microtubule","cell cycle,proliferation",3.8731,1,0,0,-0.7422,0.0561]
[22,17,"211040_X_AT","GTSE1","G-2 and S-phase expressed 1","---","---","G2 phase of mitotic cell cycle /// DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest /// microtubule-based process","---","cytoplasm /// microtubule /// cytoplasmic microtubule","cell cycle,proliferation:signal transduction,signaling pathway",2.9365,1,0,0,-0.6074,0.148]
[22,18,"203418_AT","CCNA2","cyclin A2","Cell_cycle_KEGG /// DNA_replication_Reactome /// DNA_replication_Reactome /// Proteasome_Degradation /// Ribosomal_Proteins /// Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/cellular_process-GenMAPP/Mm_DNA_replication_Reactome/Mm_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/molecular_function_GenMAPP/Rn_Ribosomal_Proteins/Rn_Ribosomal_Proteins.htm","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// protein modification process /// cell cycle /// cell cycle /// mitosis /// mitotic cell cycle G2/M transition DNA damage checkpoint /// axon guidance /// protein ubiquitination /// ER-associated protein catabolic process /// long-term strengthening of neuromuscular junction /// proteasomal ubiquitin-dependent protein catabolic process /// positive regulation of transcription /// positive regulation of transcription /// regulation of synaptic plasticity /// cell division","protein binding /// transcription regulator activity","female pronucleus /// male pronucleus /// nucleus /// nucleus /// nucleus /// cytoplasm","dna repair,transcription:cell cycle,proliferation",3.8462,1,0,0,-0.7477,0.0533]
[22,19,"204529_S_AT","TOX","thymocyte selection-associated high mobility group box","---","---","regulation of transcription, DNA-dependent","DNA binding","chromatin /// nucleus","dna repair,transcription",2.6176,-1,0,0,-0.7998,0.0308]
[22,20,"204817_AT","ESPL1","extra spindle pole bodies homolog 1 (S. cerevisiae)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","mitotic sister chromatid segregation /// regulation of progression through cell cycle /// meiotic spindle organization and biogenesis /// cytokinesis /// proteolysis /// apoptosis /// chromosome segregation /// meiosis I /// establishment of mitotic spindle localization /// homologous chromosome segregation /// positive regulation of mitotic metaphase/anaphase transition /// negative regulation of sister chromatid cohesion","catalytic activity /// protein binding /// peptidase activity /// cysteine-type peptidase activity /// cysteine-type peptidase activity /// hydrolase activity","nucleus /// cytoplasm /// centrosome","apoptosis:cell cycle,proliferation:proteolysis",3.3793,1,0,0,-0.4292,0.3366]
[22,21,"208729_X_AT","HLA-B","major histocompatibility complex, class I, B","Proteasome_Degradation /// Proteasome_Degradation /// Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","antigen processing and presentation of peptide antigen via MHC class I /// defense response /// immune response /// immune response /// antigen processing and presentation","protein binding /// MHC class I receptor activity","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane /// MHC class I protein complex","immune response",0.5726,1,0,0,0.8429,0.0172]
[22,22,"203755_AT","BUB1B","BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)","Cell_cycle_KEGG /// Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","protein amino acid phosphorylation /// apoptosis /// cell cycle /// cell cycle /// spindle organization and biogenesis /// mitosis /// mitosis /// mitosis /// mitotic cell cycle checkpoint /// cell proliferation /// negative regulation of progression through cell cycle /// phosphoinositide-mediated signaling /// cell division","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","kinetochore /// kinetochore /// kinetochore /// outer kinetochore of condensed chromosome /// anaphase-promoting complex /// cytoplasm /// cytoplasm /// spindle midzone","apoptosis:cell cycle,proliferation",3.7625,1,0,0,-0.6966,0.082]
[22,23,"38158_AT","ESPL1","extra spindle pole bodies homolog 1 (S. cerevisiae)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","mitotic sister chromatid segregation /// regulation of progression through cell cycle /// meiotic spindle organization and biogenesis /// cytokinesis /// proteolysis /// apoptosis /// chromosome segregation /// meiosis I /// establishment of mitotic spindle localization /// homologous chromosome segregation /// positive regulation of mitotic metaphase/anaphase transition /// negative regulation of sister chromatid cohesion","catalytic activity /// protein binding /// peptidase activity /// cysteine-type peptidase activity /// cysteine-type peptidase activity /// hydrolase activity","nucleus /// cytoplasm /// centrosome","apoptosis:cell cycle,proliferation:proteolysis",3.2366,1,0,0,-0.4896,0.2648]
[22,24,"201415_AT","GSS","glutathione synthetase","---","---","amino acid metabolic process /// glutathione biosynthetic process /// response to oxidative stress /// nervous system development","nucleotide binding /// catalytic activity /// glutathione synthase activity /// glutathione synthase activity /// ATP binding /// ligase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",0.3792,1,1.9732,0,0.1946,0.6758]
[22,25,"206662_AT","GLRX","glutaredoxin (thioltransferase)","---","---","electron transport /// transport /// cell redox homeostasis","electron carrier activity /// protein disulfide oxidoreductase activity /// glutathione disulfide oxidoreductase activity /// protein N-terminus binding","cytoplasm /// cytosol","transport,ion channel",2.5968,-1,0,0,-0.917,0.0036]
[22,26,"202726_AT","LIG1","ligase I, DNA, ATP-dependent","---","---","DNA metabolic process /// DNA replication /// DNA repair /// DNA repair /// DNA recombination /// response to DNA damage stimulus /// cell cycle /// anatomical structure morphogenesis /// cell division","nucleotide binding /// DNA binding /// DNA binding /// DNA ligase activity /// DNA ligase (ATP) activity /// ATP binding /// ligase activity","nucleus","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:dna replication",0.4367,1,0.7733,0,0.6387,0.1226]
[22,27,"207727_S_AT","MUTYH","mutY homolog (E. coli)","---","---","DNA repair /// DNA repair /// base-excision repair /// mismatch repair /// response to DNA damage stimulus /// cell cycle /// metabolic process /// negative regulation of progression through cell cycle","DNA binding /// endonuclease activity /// iron ion binding /// protein binding /// hydrolase activity /// hydrolase activity, acting on glycosyl bonds /// DNA N-glycosylase activity /// MutLalpha complex binding /// MutLbeta complex binding /// MutSalpha complex binding /// MutSbeta complex binding /// metal ion binding /// iron-sulfur cluster binding /// 4 iron, 4 sulfur cluster binding","intracellular /// nucleus","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",1.4345,1,0,0,-0.2684,0.5606]
[22,28,"203528_AT","SEMA4D","sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D","---","---","anti-apoptosis /// immune response /// cell adhesion /// multicellular organismal development /// nervous system development /// cell differentiation /// positive regulation of axonogenesis","receptor activity /// receptor activity /// receptor binding /// receptor binding","membrane /// integral to membrane","cell growth,differentiation:cell adhesion:apoptosis:immune response",2.7891,-1,0,0,-0.8206,0.0237]
[22,29,"209408_AT","KIF2C","kinesin family member 2C","---","---","microtubule-based movement /// mitosis /// cell proliferation /// establishment and/or maintenance of microtubule cytoskeleton polarity","nucleotide binding /// motor activity /// microtubule motor activity /// microtubule motor activity /// protein binding /// ATP binding /// centromeric DNA binding","chromosome, pericentric region /// cytoplasm /// kinesin complex /// microtubule /// microtubule associated complex /// microtubule cytoskeleton","cell cycle,proliferation:nuclear matrix,cytoskeleton",3.7785,1,0,0,-0.6776,0.0944]
[22,30,"209849_S_AT","RAD51C","RAD51 homolog C (S. cerevisiae)","---","---","DNA metabolic process /// DNA repair /// DNA repair /// DNA recombination /// DNA recombination /// response to DNA damage stimulus","nucleotide binding /// DNA binding /// DNA binding /// ATP binding /// DNA-dependent ATPase activity /// nucleoside-triphosphatase activity","nucleus","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process",1.2028,1,0.0006,0,0.3346,0.4632]
[22,31,"201720_S_AT","LAPTM5","lysosomal associated multispanning membrane protein 5","---","---","transport","---","lysosome /// lysosome /// integral to plasma membrane /// membrane /// integral to membrane","transport,ion channel",0.4598,1,0,0,0.1481,0.7513]
[22,32,"202705_AT","CCNB2","cyclin B2","Cell_cycle_KEGG /// Cell_cycle_KEGG /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","regulation of progression through cell cycle /// translation /// translational initiation /// regulation of translational initiation /// cell cycle /// mitosis /// cell division","translation initiation factor activity /// translation initiation factor activity /// protein binding","nucleus /// eukaryotic translation initiation factor 3 complex /// microtubule cytoskeleton","cell cycle,proliferation",4.7316,-1,0,0,-0.9412,0.0016]
[22,33,"222039_AT","LOC146909","hypothetical protein LOC146909","---","---","---","---","---","unknown",4.198,1,0,0,-0.6664,0.1021]
[22,34,"202954_AT","UBE2C","ubiquitin-conjugating enzyme E2C","---","---","protein modification process /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle /// cell cycle /// cell cycle /// spindle organization and biogenesis /// mitosis /// cyclin catabolic process /// protein ubiquitination /// positive regulation of exit from mitosis /// phosphoinositide-mediated signaling /// cell division","ubiquitin-protein ligase activity /// ubiquitin-protein ligase activity /// ligase activity /// small conjugating protein ligase activity","---","cell cycle,proliferation",4.161,-1,0,0,-0.9167,0.0037]
[22,35,"204674_AT","LRMP","lymphoid-restricted membrane protein","---","---","vesicle targeting /// vesicle fusion /// hemocyte development","---","cytoplasm /// endoplasmic reticulum /// endoplasmic reticulum membrane /// integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane",null,0.9969,1,0,0,0.7036,0.0777]
[22,36,"219019_AT","---","---","---","---","---","---","---","unknown",0.4831,1,0.7946,0,0.3457,0.4476]
[22,37,"206571_S_AT","MAP4K4","mitogen-activated protein kinase kinase kinase kinase 4","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// response to stress /// protein kinase cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// small GTPase regulator activity /// ATP binding /// ATP binding /// kinase activity /// transferase activity","---",null,0.8835,1,1.1737,0,0.5053,0.2474]
[22,38,"203509_AT","SORL1","sortilin-related receptor, L(DLR class) A repeats-containing","---","---","lipid metabolic process /// transport /// lipid transport /// endocytosis /// receptor-mediated endocytosis /// steroid metabolic process /// cholesterol metabolic process","receptor activity /// transmembrane receptor activity /// lipid transporter activity","integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",0.745,1,1.6949,0,0.2524,0.585]
[22,39,"219863_AT","HERC5","hect domain and RLD 5","---","---","regulation of cyclin-dependent protein kinase activity /// protein modification process /// ubiquitin cycle","ubiquitin-protein ligase activity /// ligase activity","intracellular /// cytoplasm",null,1.0149,1,0,0,0.3032,0.5085]
[]
[null,null,23]
[23,1,"216351_X_AT","DAZ1 /// DAZ2 /// DAZ3 /// DAZ4","deleted in azoospermia 1 /// deleted in azoospermia 3 /// deleted in azoospermia 2 /// deleted in azoospermia 4","---","---","multicellular organismal development /// spermatogenesis /// single fertilization /// cell differentiation /// positive regulation of translational initiation","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// protein binding /// translation activator activity","cytoplasm","cell growth,differentiation",3.7028,1,0,5,0.2586,0.5755]
[23,2,"211682_X_AT","UGT2B28","UDP glucuronosyltransferase 2 family, polypeptide B28","---","---","xenobiotic metabolic process /// metabolic process /// metabolic process","glucuronosyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups /// transferase activity, transferring hexosyl groups","endoplasmic reticulum /// endoplasmic reticulum /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",2.7984,1,0,3,0.2354,0.6114]
[23,3,"209646_X_AT","ALDH1B1","aldehyde dehydrogenase 1 family, member B1","---","---","carbohydrate metabolic process /// metabolic process","3-chloroallyl aldehyde dehydrogenase activity /// aldehyde dehydrogenase (NAD) activity /// oxidoreductase activity","mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",4.5778,1,0,4,0.4176,0.3513]
[23,4,"207978_S_AT","NR4A3","nuclear receptor subfamily 4, group A, member 3","Hypertrophy_model","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Hypertrophy_model/Hs_Hypertrophy_model.htm","mesoderm formation /// transcription /// regulation of transcription, DNA-dependent","DNA binding /// DNA binding /// transcription factor activity /// steroid hormone receptor activity /// steroid hormone receptor activity /// receptor activity /// ligand-dependent nuclear receptor activity /// thyroid hormone receptor activity /// binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding","nucleus /// nucleus","dna repair,transcription",5.9185,-1,0,4,0.3942,0.3816]
[23,5,"201466_S_AT","JUN","jun oncogene","Apoptosis /// Apoptosis_GenMAPP /// MAPK_Cascade /// Smooth_muscle_contraction /// TGF_Beta_Signaling_Pathway /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_MAPK_Cascade/Hs_MAPK_Cascade.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","regulation of progression through cell cycle /// transcription /// regulation of transcription, DNA-dependent /// cellular process /// leading edge cell differentiation /// regulation of transcription /// positive regulation of transcription from RNA polymerase II promoter","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// RNA polymerase II transcription factor activity /// protein binding /// protein binding /// sequence-specific DNA binding /// protein dimerization activity","nuclear chromosome /// nucleus /// transcription factor complex","dna repair,transcription:cell growth,differentiation:cell cycle,proliferation",9.7096,-1,0,3,0.2512,0.5869]
[]
[null,null,24]
[24,1,"213599_AT","OIP5","Opa interacting protein 5","---","---","cell communication","protein binding /// protein binding","chromatin /// nucleus /// Cajal body",null,10.3699,1,0,-2,-0.9076,0.0047]
[24,2,"208296_X_AT","TNFAIP8","tumor necrosis factor, alpha-induced protein 8","---","---","apoptosis /// anti-apoptosis /// negative regulation of anti-apoptosis","caspase inhibitor activity","cytoplasm /// cytoplasm","apoptosis",16.4253,1,0,-3,-0.5183,0.2334]
[24,3,"209284_S_AT","C3orf63","chromosome 3 open reading frame 63","---","---","---","---","---","unknown",12.8843,1,0,-1,-0.7164,0.0701]
[24,4,"205646_S_AT","PAX6","paired box 6","---","---","eye development /// transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development /// central nervous system development /// visual perception /// organ morphogenesis /// cell differentiation /// regulation of transcription","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// protein binding /// sequence-specific DNA binding","nucleus","dna repair,transcription:cell growth,differentiation",15.357,1,0,0,-0.7776,0.0396]
[24,5,"217878_S_AT","CDC27","cell division cycle 27 homolog (S. cerevisiae)","---","---","mitotic metaphase/anaphase transition /// mitotic metaphase/anaphase transition /// cell proliferation","binding /// protein binding","anaphase-promoting complex /// cytoplasm /// centrosome /// centrosome /// spindle /// spindle microtubule","cell cycle,proliferation",10.7912,-1,0.0007,-3,-0.8515,0.015]
[24,6,"209574_S_AT","C18orf1","chromosome 18 open reading frame 1","---","---","---","---","membrane /// integral to membrane /// integral to membrane","unknown",11.5698,1,1.3486,-1,-0.8512,0.0151]
[24,7,"202761_S_AT","SYNE2","spectrin repeat containing, nuclear envelope 2","Nuclear_Receptors /// Ovarian_Infertility_Genes","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Nuclear_Receptors/Hs_Nuclear_Receptors.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// signal transduction /// cell-cell signaling /// negative regulation of cell growth /// estrogen receptor signaling pathway","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// steroid hormone receptor activity /// steroid hormone receptor activity /// transcription coactivator activity /// actin binding /// receptor activity /// ligand-dependent nuclear receptor activity /// ligand-dependent nuclear receptor activity /// structural molecule activity /// steroid binding /// steroid binding /// protein binding /// zinc ion binding /// lipid binding /// estrogen receptor activity /// sequence-specific DNA binding /// metal ion binding /// receptor antagonist activity","nucleus /// nucleus /// cytoplasm /// mitochondrion /// cytoskeleton /// membrane /// integral to membrane","dna repair,transcription:cell growth,differentiation:signal transduction,signaling pathway",15.7546,1,0,-3,-0.5408,0.2101]
[24,8,"210644_S_AT","LAIR1","leukocyte-associated immunoglobulin-like receptor 1","---","---","immune response","receptor activity","membrane /// integral to membrane","immune response",8.9113,-1,0,-1,-0.615,0.1416]
[24,9,"202797_AT","SACM1L","SAC1 suppressor of actin mutations 1-like (yeast)","---","---","---","---","Golgi apparatus","unknown",8.6987,1,0,-1,-0.8781,0.0093]
[24,10,"215942_S_AT","GTSE1","G-2 and S-phase expressed 1","---","---","G2 phase of mitotic cell cycle /// DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest /// microtubule-based process","---","cytoplasm /// microtubule /// cytoplasmic microtubule","cell cycle,proliferation:signal transduction,signaling pathway",8.7804,-1,0,-2,-0.8708,0.0107]
[24,11,"212543_AT","AIM1","absent in melanoma 1","---","---","---","sugar binding","---","unknown",7.335,-1,0,0,-0.9588,0.0006]
[24,12,"218355_AT","KIF4A","kinesin family member 4A","---","---","organelle organization and biogenesis /// microtubule-based movement /// anterograde axon cargo transport","nucleotide binding /// DNA binding /// motor activity /// microtubule motor activity /// microtubule motor activity /// protein binding /// ATP binding","cytoplasm /// microtubule /// microtubule associated complex /// spindle microtubule","transport,ion channel",12.7271,1,0,0,-0.8678,0.0114]
[24,13,"202770_S_AT","CCNG2","cyclin G2","G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// cell cycle checkpoint /// cell cycle /// mitosis /// cell division","---","cytoplasm","cell cycle,proliferation",160.1508,1,0,-2,-0.7926,0.0335]
[24,14,"211795_S_AT","FYB","FYN binding protein (FYB-120/130)","---","---","carbohydrate metabolic process /// protein amino acid phosphorylation /// NLS-bearing substrate import into nucleus /// immune response /// signal transduction /// protein kinase cascade","receptor binding /// protein binding /// xylose isomerase activity","nucleus /// cytoplasm /// actin cytoskeleton","biosynthesis,metabolism,metabolic process,biosynthetic process:immune response:signal transduction,signaling pathway",7.4205,-1,0.0003,-1,-0.9065,0.0049]
[24,15,"212738_AT","ARHGAP19","Rho GTPase activating protein 19","---","---","signal transduction /// G-protein coupled receptor protein signaling pathway /// multicellular organismal development /// nervous system development /// nervous system development /// axon guidance /// brain development /// cell differentiation","follicle-stimulating hormone receptor activity /// GTPase activator activity /// calcium ion binding /// calcium ion binding /// protein binding /// protein binding","extracellular space /// intracellular /// integral to membrane","cell growth,differentiation:signal transduction,signaling pathway",17.8658,1,0,-3,-0.9783,0.0001]
[24,16,"203761_AT","SLA","Src-like-adaptor","---","---","intracellular signaling cascade","SH3/SH2 adaptor activity","cytoplasm /// endosome",null,13.0518,1,0,-1,-0.4636,0.2947]
[24,17,"209276_S_AT","GLRX","glutaredoxin (thioltransferase)","---","---","electron transport /// transport /// cell redox homeostasis","electron carrier activity /// protein disulfide oxidoreductase activity /// glutathione disulfide oxidoreductase activity /// protein N-terminus binding","cytoplasm /// cytosol","transport,ion channel",4.696,-1,0,-1,-0.9849,0.0001]
[24,18,"212023_S_AT","MKI67","antigen identified by monoclonal antibody Ki-67","---","---","regulation of progression through cell cycle /// cell cycle /// cell proliferation","nucleotide binding /// protein binding /// ATP binding","nucleolus","cell cycle,proliferation",13.3268,1,0,-1,-0.9004,0.0057]
[24,19,"221685_S_AT","CCDC99","coiled-coil domain containing 99","---","---","---","---","---","unknown",22.3626,1,0,-1,-0.8013,0.0303]
[24,20,"209537_AT","EXTL2","exostoses (multiple)-like 2","---","---","N-acetylglucosamine metabolic process /// UDP-N-acetylgalactosamine metabolic process","glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity /// glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups /// manganese ion binding /// alpha-1,4-N-acetylgalactosaminyltransferase activity /// metal ion binding","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",13.7761,1,0,-2,-0.8848,0.0081]
[24,21,"213326_AT","VAMP1","vesicle-associated membrane protein 1 (synaptobrevin 1)","---","---","vesicle-mediated transport","---","mitochondrion /// integral to plasma membrane /// synaptic vesicle /// membrane /// integral to membrane /// synaptosome /// cell junction /// cytoplasmic vesicle /// synapse","transport,ion channel",9.8962,-1,0,0,-0.7236,0.066]
[24,22,"218663_AT","NCAPG","non-SMC condensin I complex, subunit G","---","---","cell cycle /// mitosis /// mitotic chromosome condensation /// mitotic chromosome condensation /// cell division","protein binding","nucleus /// cytoplasm","cell cycle,proliferation",19.1347,1,0,-3,-0.6505,0.1137]
[24,23,"202769_AT","CCNG2","cyclin G2","G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// cell cycle checkpoint /// cell cycle /// mitosis /// cell division","---","cytoplasm","cell cycle,proliferation",12.2556,-1,0,-1,-0.8188,0.0243]
[24,24,"209464_AT","AURKB","aurora kinase B","---","---","protein amino acid phosphorylation /// cell cycle /// mitosis /// cell division","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","chromosome, pericentric region /// chromosome","cell cycle,proliferation",12.7292,1,0,0,-0.7502,0.0521]
[24,25,"219502_AT","NEIL3","nei endonuclease VIII-like 3 (E. coli)","---","---","DNA repair /// base-excision repair /// response to DNA damage stimulus","DNA binding /// damaged DNA binding /// zinc ion binding /// oxidized purine base lesion DNA N-glycosylase activity /// metal ion binding","intracellular","dna repair,transcription",41.3461,1,0,-1,-0.6882,0.0874]
[24,26,"212124_AT","ZMIZ1","zinc finger, MIZ-type containing 1","---","---","transcription /// regulation of transcription, DNA-dependent","zinc ion binding /// metal ion binding","cytoplasm","dna repair,transcription",11.4242,-1,0,0,-0.7714,0.0423]
[24,27,"218542_AT","CEP55","centrosomal protein 55kDa","---","---","cell cycle /// mitosis /// cell division","---","---","cell cycle,proliferation",9.3988,-1,0,-2,-0.8942,0.0066]
[24,28,"207445_S_AT","CCR9","chemokine (C-C motif) receptor 9","GPCRDB_Class_A_Rhodopsin-like /// Peptide_GPCRs","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Class_A_Rhodopsin-like/Hs_GPCRDB_Class_A_Rhodopsin-like.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Peptide_GPCRs/Hs_Peptide_GPCRs.htm","chemotaxis /// immune response /// cellular defense response /// signal transduction /// G-protein coupled receptor protein signaling pathway /// G-protein coupled receptor protein signaling pathway /// elevation of cytosolic calcium ion concentration","rhodopsin-like receptor activity /// signal transducer activity /// receptor activity /// G-protein coupled receptor activity /// chemokine receptor activity /// C-C chemokine receptor activity","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","immune response:signal transduction,signaling pathway",18.9171,1,0,0,-0.6629,0.1046]
[24,29,"202094_AT","BIRC5","baculoviral IAP repeat-containing 5 (survivin)","Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","G2/M transition of mitotic cell cycle /// cytokinesis /// apoptosis /// anti-apoptosis /// anti-apoptosis /// cell cycle /// mitosis /// protein complex localization /// protein complex localization /// positive regulation of exit from mitosis /// spindle checkpoint /// negative regulation of caspase activity /// positive regulation of progression through mitotic cell cycle /// cell division /// cell division /// establishment of chromosome localization","endopeptidase inhibitor activity /// cysteine protease inhibitor activity /// protein binding /// protein binding /// microtubule binding /// zinc ion binding /// zinc ion binding /// tubulin binding /// identical protein binding /// protein homodimerization activity /// caspase inhibitor activity /// metal ion binding /// protein heterodimerization activity /// cofactor binding","chromosome, pericentric region /// chromosome, pericentric region /// chromosome, pericentric region /// intracellular /// chromosome /// cytoplasm /// cytoplasm /// cytoplasm /// centriole /// cytosol /// spindle microtubule /// cytoplasmic microtubule /// midbody /// midbody /// interphase microtubule organizing center /// protein complex /// protein complex","apoptosis:cell cycle,proliferation",11.3037,-1,0,-1,-0.8855,0.008]
[24,30,"204774_AT","EVI2A","ecotropic viral integration site 2A","---","---","---","transmembrane receptor activity","membrane /// integral to membrane","unknown",9.447,-1,0,-2,-0.9358,0.0019]
[24,31,"204649_AT","TROAP","trophinin associated protein (tastin)","---","---","cell adhesion /// cell adhesion","protein binding","cytoplasm /// cytoplasm","cell adhesion",13.8369,1,0,-1,-0.6876,0.0878]
[24,32,"205046_AT","CENPE","centromere protein E, 312kDa","---","---","mitotic metaphase /// microtubule-based movement /// cell cycle /// mitosis /// mitotic chromosome movement towards spindle pole /// mitotic metaphase plate congression /// cell division /// kinetochore assembly","nucleotide binding /// motor activity /// microtubule motor activity /// microtubule motor activity /// protein binding /// ATP binding /// kinetochore binding","chromosome, pericentric region /// chromosome, pericentric region /// outer kinetochore of condensed chromosome /// nucleus /// nucleus /// microtubule /// microtubule associated complex","cell cycle,proliferation",12.8137,-1,0,-3,-0.9259,0.0028]
[24,33,"209642_AT","BUB1","BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","protein amino acid phosphorylation /// cell cycle /// mitosis /// mitotic cell cycle checkpoint /// mitotic cell cycle spindle assembly checkpoint /// cell proliferation /// cell division","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity","kinetochore /// spindle pole body","cell cycle,proliferation",12.1459,1,0,-3,-0.9638,0.0005]
[24,34,"202870_S_AT","CDC20","cell division cycle 20 homolog (S. cerevisiae)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of progression through cell cycle /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle /// cell cycle /// cell cycle /// mitosis /// cell division","protein binding","spindle","cell cycle,proliferation",8.4128,-1,0,0,-0.954,0.0008]
[24,35,"207165_AT","HMMR","hyaluronan-mediated motility receptor (RHAMM)","---","---","cell motility","receptor activity /// hyaluronic acid binding","cytoplasm",null,12.0387,-1,0,-3,-0.9014,0.0056]
[24,36,"203764_AT","DLG7","discs, large homolog 7 (Drosophila)","---","---","M phase of mitotic cell cycle /// M phase of mitotic cell cycle /// cell cycle /// mitotic chromosome movement towards spindle pole /// cell-cell signaling /// cell proliferation /// positive regulation of mitotic metaphase/anaphase transition","phosphoprotein phosphatase activity /// phosphoprotein phosphatase activity /// protein binding","nucleus /// nucleus /// cytoplasm /// spindle pole centrosome /// spindle pole centrosome","cell cycle,proliferation",10.8636,-1,0,-2,-0.9355,0.002]
[24,37,"211935_AT","ARL6IP1","ADP-ribosylation factor-like 6 interacting protein 1","---","---","cotranslational protein targeting to membrane","protein binding","cytoplasm /// translocon complex /// cytosol /// membrane /// integral to membrane",null,8.6561,-1,0,-3,-0.9513,0.001]
[24,38,"209709_S_AT","HMMR","hyaluronan-mediated motility receptor (RHAMM)","---","---","cell motility","receptor activity /// hyaluronic acid binding","cytoplasm",null,78.734,1,0,-2,-0.8633,0.0123]
[24,39,"204092_S_AT","AURKA","aurora kinase A","---","---","mitotic cell cycle /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// cell cycle /// cell cycle /// spindle organization and biogenesis /// mitosis /// regulation of protein stability /// phosphoinositide-mediated signaling","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// protein binding /// ATP binding /// kinase activity /// transferase activity /// ubiquitin protein ligase binding","nucleus /// spindle","cell cycle,proliferation",10.9957,-1,0,-3,-0.8231,0.0229]
[24,40,"214710_S_AT","CCNB1","cyclin B1","Cell_cycle_KEGG /// Cell_cycle_KEGG /// Cell_cycle_KEGG /// Cell_cycle_KEGG /// Cell_cycle_KEGG /// Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// G2/M transition of mitotic cell cycle /// cell cycle /// mitosis /// cell division","protein binding","nucleus /// nucleus /// cytoplasm","cell cycle,proliferation",14.0954,-1,0,-1,-0.9643,0.0005]
[24,41,"204962_S_AT","CENPA","centromere protein A","---","---","nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// chromosome organization and biogenesis (sensu Eukaryota)","DNA binding /// chromatin binding","chromosome, pericentric region /// chromosome, pericentric region /// chromosome, pericentric region /// nucleosome /// nucleus /// nucleus /// chromosome /// membrane /// integral to membrane",null,13.3297,-1,0,-3,-0.827,0.0217]
[]
[null,null,25]
[25,1,"213593_S_AT","TRA2A","transformer-2 alpha","---","---","nuclear mRNA splicing, via spliceosome /// mRNA processing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// identical protein binding","nucleus",null,11.5264,1,1.5775,-4,-0.8185,0.0244]
[25,2,"202537_S_AT","CHMP2B","chromatin modifying protein 2B","---","---","transport /// protein transport","protein binding","intracellular /// cytoplasm","transport,ion channel",7.9933,1,0,-2,0.0029,0.9951]
[25,3,"212887_AT","SEC23A","Sec23 homolog A (S. cerevisiae)","---","---","transport /// intracellular protein transport /// ER to Golgi vesicle-mediated transport /// protein transport /// vesicle-mediated transport","protein binding /// protein binding /// zinc ion binding","Golgi membrane /// endoplasmic reticulum /// endoplasmic reticulum /// cytosol /// membrane /// COPII vesicle coat /// perinuclear region of cytoplasm","transport,ion channel",11.9566,1,0,-4,-0.5531,0.1978]
[25,4,"220553_S_AT","PRPF39","PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)","---","---","RNA processing /// mRNA processing /// RNA splicing","binding","intracellular",null,8.5752,1,0,-4,-0.3097,0.4991]
[25,5,"208938_AT","PRCC","papillary renal cell carcinoma (translocation-associated)","---","---","---","---","---","unknown",6.2528,-1,0,-4,0.0882,0.8509]
[25,6,"218911_AT","YEATS4","YEATS domain containing 4","---","---","regulation of cell growth /// transcription /// regulation of transcription, DNA-dependent /// mitosis /// chromatin modification /// positive regulation of transcription, DNA-dependent","DNA binding /// transcription factor activity /// structural constituent of cytoskeleton /// protein binding /// protein binding /// protein C-terminus binding","nucleus /// nucleus /// nucleoplasm /// nuclear matrix","dna repair,transcription:cell growth,differentiation",10.5236,1,0,-4,-0.4622,0.2964]
[25,7,"217858_S_AT","ARMCX3","armadillo repeat containing, X-linked 3","---","---","---","binding","membrane /// integral to membrane","unknown",5.3088,1,0.4909,-4,0.0235,0.9602]
[25,8,"209028_S_AT","ABI1","abl-interactor 1","---","---","transmembrane receptor protein tyrosine kinase signaling pathway /// negative regulation of cell proliferation","protein binding /// cytoskeletal protein binding","soluble fraction /// cytoplasm /// endoplasmic reticulum /// cytosol /// cytoskeleton /// synaptosome /// cell junction /// cell projection /// synapse","cell cycle,proliferation:signal transduction,signaling pathway",11.6167,1,0,-2,-0.6868,0.0883]
[25,9,"210970_S_AT","IBTK","inhibitor of Bruton agammaglobulinemia tyrosine kinase","---","---","---","protein binding","cytoplasm /// membrane","unknown",10.3733,1,0,-6,-0.2898,0.5285]
[25,10,"201737_S_AT","2008-03-06","membrane-associated ring finger (C3HC4) 6","---","---","ubiquitin cycle","protein binding /// zinc ion binding /// ligase activity /// metal ion binding","endoplasmic reticulum /// membrane /// integral to membrane",null,13.8378,1,1.8558,-4,-0.6337,0.1265]
[25,11,"214683_S_AT","CLK1","CDC-like kinase 1","---","---","regulation of progression through cell cycle /// protein amino acid phosphorylation /// cell proliferation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein-tyrosine kinase activity /// non-membrane spanning protein tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity","---","cell cycle,proliferation",5.711,-1,0.7996,-4,-0.1714,0.7133]
[25,12,"222266_AT","C19orf2","Chromosome 19 open reading frame 2","---","---","regulation of transcription from RNA polymerase II promoter /// protein folding /// response to virus","transcription corepressor activity /// unfolded protein binding","nucleus /// DNA-directed RNA polymerase II, core complex /// cytoplasm /// prefoldin complex","dna repair,transcription",12.4593,1,0,-2,-0.4045,0.3681]
[25,13,"218395_AT","ACTR6","ARP6 actin-related protein 6 homolog (yeast)","---","---","---","structural molecule activity /// protein binding","cytoplasm /// cytoskeleton","unknown",10.923,1,0,-2,-0.4689,0.2885]
[25,14,"207996_S_AT","C18orf1","chromosome 18 open reading frame 1","---","---","---","---","membrane /// integral to membrane /// integral to membrane","unknown",14.9015,1,1.3073,-2,-0.8329,0.02]
[25,15,"219957_AT","RUFY2","RUN and FYVE domain containing 2","---","---","---","zinc ion binding /// metal ion binding","---","unknown",14.7945,1,0,-2,-0.7816,0.0379]
[25,16,"219972_S_AT","C14orf135","chromosome 14 open reading frame 135","---","---","---","---","integral to membrane","unknown",8.1395,1,0,-4,-0.3179,0.4871]
[25,17,"202381_AT","ADAM9","ADAM metallopeptidase domain 9 (meltrin gamma)","---","---","proteolysis /// protein kinase cascade","metalloendopeptidase activity /// integrin binding /// protein binding /// peptidase activity /// metallopeptidase activity /// metallopeptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// SH3 domain binding /// protein kinase binding /// metal ion binding","cytoplasm /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane","proteolysis",10.2744,1,0,-4,-0.266,0.5643]
[25,18,"204646_AT","DPYD","dihydropyrimidine dehydrogenase","---","---","electron transport /// 'de novo' pyrimidine base biosynthetic process /// uracil catabolic process /// thymidine catabolic process /// metabolic process","catalytic activity /// dihydroorotate dehydrogenase activity /// dihydroorotate oxidase activity /// iron ion binding /// electron carrier activity /// oxidoreductase activity /// dihydropyrimidine dehydrogenase (NADP+) activity /// dihydropyrimidine dehydrogenase (NADP+) activity /// metal ion binding /// FAD binding /// iron-sulfur cluster binding /// 4 iron, 4 sulfur cluster binding","cytoplasm /// cytoplasm /// membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",16.2777,1,0,-2,-0.64,0.1216]
[25,19,"219787_S_AT","ECT2","epithelial cell transforming sequence 2 oncogene","---","---","intracellular signaling cascade /// regulation of Rho protein signal transduction /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity /// protein binding","intracellular","signal transduction,signaling pathway",18.351,1,1.3195,-6,-0.9428,0.0015]
[25,20,"205269_AT","LCP2","lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)","---","---","immune response /// transmembrane receptor protein tyrosine kinase signaling pathway /// intracellular signaling cascade /// mast cell activation /// cytokine secretion","protein binding /// protein binding","cytoplasm","immune response:signal transduction,signaling pathway",17.9363,1,0,-2,-0.9311,0.0023]
[25,21,"202541_AT","SCYE1","small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)","---","---","translation /// tRNA aminoacylation for protein translation /// chemotaxis /// inflammatory response /// signal transduction /// cell-cell signaling /// response to wounding","tRNA binding /// tRNA binding /// RNA binding /// cytokine activity /// cytokine activity","extracellular space /// extracellular space","signal transduction,signaling pathway",13.97,1,0,-4,-0.319,0.4856]
[25,22,"201170_S_AT","BHLHB2","basic helix-loop-helix domain containing, class B, 2","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// regulation of transcription /// negative regulation of transcription, DNA-dependent","DNA binding /// transcription factor activity /// protein binding /// transcription repressor activity /// transcription regulator activity","nucleus /// nucleus","dna repair,transcription",28.3023,1,0,-2,-0.4985,0.2549]
[25,23,"217678_AT","SLC7A11","solute carrier family 7, (cationic amino acid transporter, y+ system) member 11","---","---","protein complex assembly /// transport /// amino acid transport","amino acid transmembrane transporter activity /// cystine:glutamate antiporter activity","membrane /// integral to membrane /// integral to membrane","transport,ion channel",15.5027,1,0,-2,-0.143,0.7597]
[25,24,"211137_S_AT","ATP2C1","ATPase, Ca++ transporting, type 2C, member 1","---","---","transport /// ion transport /// cation transport /// calcium ion transport /// calcium ion transport /// calcium ion transport /// cellular calcium ion homeostasis /// cellular calcium ion homeostasis /// metabolic process /// epidermis development /// proton transport /// calcium-dependent cell-cell adhesion /// actin cytoskeleton reorganization /// Golgi calcium ion homeostasis /// Golgi calcium ion transport /// positive regulation of I-kappaB kinase/NF-kappaB cascade","nucleotide binding /// magnesium ion binding /// catalytic activity /// signal transducer activity /// calcium-transporting ATPase activity /// calcium-transporting ATPase activity /// calcium-transporting ATPase activity /// calcium ion binding /// ATP binding /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances /// metal ion binding","Golgi membrane /// Golgi apparatus /// trans-Golgi network /// membrane /// integral to membrane /// integral to membrane","cell adhesion:biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:nuclear matrix,cytoskeleton",7.661,1,0,-2,0.246,0.5948]
[25,25,"209822_S_AT","VLDLR","very low density lipoprotein receptor","---","---","lipid metabolic process /// transport /// lipid transport /// endocytosis /// signal transduction /// nervous system development /// memory /// steroid metabolic process /// cholesterol metabolic process","receptor activity /// low-density lipoprotein receptor activity /// lipid transporter activity /// calcium ion binding","membrane fraction /// plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:signal transduction,signaling pathway",19.6555,1,1.9771,-4,-0.2364,0.6097]
[25,26,"206070_S_AT","EPHA3","EPH receptor A3","---","---","protein amino acid phosphorylation /// signal transduction /// transmembrane receptor protein tyrosine kinase signaling pathway","nucleotide binding /// protein kinase activity /// protein-tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// receptor activity /// ephrin receptor activity /// ATP binding /// kinase activity /// transferase activity","integral to plasma membrane /// membrane /// integral to membrane","signal transduction,signaling pathway",18.206,1,1.2884,-4,-0.4323,0.3327]
[25,27,"216060_S_AT","DAAM1","dishevelled associated activator of morphogenesis 1","---","---","cellular component organization and biogenesis /// actin cytoskeleton organization and biogenesis","actin binding /// Rho GTPase binding","cytoplasm","nuclear matrix,cytoskeleton",9.238,1,0,2,0.2032,0.6622]
[25,28,"206036_S_AT","REL","v-rel reticuloendotheliosis viral oncogene homolog (avian)","---","---","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// positive regulation of I-kappaB kinase/NF-kappaB cascade /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// signal transducer activity","nucleus","dna repair,transcription",8.4275,1,0.7972,-2,0.2844,0.5365]
[]
[null,null,26]
[26,1,"213039_AT","ARHGEF18","rho/rac guanine nucleotide exchange factor (GEF) 18","---","---","small GTPase mediated signal transduction /// regulation of cell shape /// actin cytoskeleton organization and biogenesis /// regulation of Rho protein signal transduction","guanyl-nucleotide exchange factor activity /// guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity","intracellular","nuclear matrix,cytoskeleton:signal transduction,signaling pathway",1.7194,-1,0,-4,-0.9647,0.0004]
[26,2,"219306_AT","KIF15","kinesin family member 15","---","---","microtubule-based movement /// mitosis /// cell proliferation","nucleotide binding /// DNA binding /// motor activity /// motor activity /// microtubule motor activity /// receptor activity /// ATP binding","centrosome /// plus-end kinesin complex /// microtubule /// microtubule associated complex","cell cycle,proliferation",3.5158,1,0,-6,-0.888,0.0076]
[26,3,"204444_AT","KIF11","kinesin family member 11","---","---","microtubule-based movement /// cell cycle /// mitotic spindle organization and biogenesis /// mitosis /// mitosis /// mitotic centrosome separation /// spindle pole body organization and biogenesis /// cell division","nucleotide binding /// motor activity /// microtubule motor activity /// microtubule motor activity /// ATP binding","spindle pole /// spindle /// kinesin complex /// microtubule /// microtubule associated complex /// spindle microtubule","cell cycle,proliferation",4.6656,1,0,-4,-0.8355,0.0192]
[26,4,"208610_S_AT","SRRM2","serine/arginine repetitive matrix 2","---","---","mRNA processing /// RNA splicing","RNA binding /// protein binding","spliceosome",null,11.1939,-1,1.1565,-4,-0.5053,0.2474]
[26,5,"31861_AT","IGHMBP2","immunoglobulin mu binding protein 2","---","---","DNA replication /// DNA repair /// DNA recombination /// transcription /// regulation of transcription, DNA-dependent","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA helicase activity /// single-stranded DNA binding /// helicase activity /// protein binding /// ATP binding /// zinc ion binding /// hydrolase activity /// nucleoside-triphosphatase activity /// metal ion binding","nucleus /// cytoplasm /// axon /// cell soma","dna repair,transcription:dna replication",2.7142,1,0,-2,0.267,0.5627]
[26,6,"207614_S_AT","CUL1","cullin 1","---","---","G1/S transition of mitotic cell cycle /// ubiquitin cycle /// cell cycle /// cell cycle arrest /// negative regulation of cell proliferation /// induction of apoptosis by intracellular signals","protein binding","---","apoptosis:cell cycle,proliferation",1.037,1,0.0002,-2,0.2006,0.6663]
[26,7,"205961_S_AT","PSIP1","PC4 and SFRS1 interacting protein 1","---","---","transcription /// regulation of transcription, DNA-dependent","DNA binding","---","dna repair,transcription",0.709,-1,0.001,-4,-0.9341,0.0021]
[26,8,"210260_S_AT","TNFAIP8","tumor necrosis factor, alpha-induced protein 8","---","---","apoptosis /// anti-apoptosis /// negative regulation of anti-apoptosis","caspase inhibitor activity","cytoplasm /// cytoplasm","apoptosis",2.9755,1,1.8317,-4,-0.5775,0.1746]
[26,9,"210038_AT","PRKCQ","protein kinase C, theta","Calcium_regulation_in_cardiac_cells /// G_Protein_Signaling /// Smooth_muscle_contraction /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","regulation of cell growth /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// intracellular signaling cascade /// intracellular signaling cascade /// positive regulation of T cell proliferation /// positive regulation of interleukin-2 biosynthetic process /// positive regulation of T cell activation /// activation of NF-kappaB transcription factor","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein kinase C activity /// protein binding /// ATP binding /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding","immunological synapse /// intracellular /// cytoplasm /// plasma membrane","dna repair,transcription:cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",4.2448,1,0,-6,-0.8701,0.0109]
[26,10,"212801_AT","CIT","citron (rho-interacting, serine/threonine kinase 21)","G13_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G13_Signaling_Pathway/Hs_G13_Signaling_Pathway.htm","protein amino acid phosphorylation /// cell cycle /// mitosis /// mitosis /// intracellular signaling cascade /// multicellular organismal development /// nervous system development /// cell differentiation /// generation of neurons /// cell division","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// small GTPase regulator activity /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding","cytoplasm","cell growth,differentiation:cell cycle,proliferation",4.5733,1,0,-2,-0.4404,0.3227]
[26,11,"209680_S_AT","KIFC1","kinesin family member C1","---","---","mitotic sister chromatid segregation /// microtubule-based movement","nucleotide binding /// motor activity /// microtubule motor activity /// microtubule motor activity /// ATP binding /// ATP binding","microtubule /// microtubule associated complex /// microtubule associated complex",null,3.9528,1,0,-6,-0.5716,0.18]
[26,12,"201924_AT","AFF1","AF4/FMR2 family, member 1","---","---","---","transcription factor activity","---","unknown",4.287,-1,0,-4,-0.9628,0.0005]
[26,13,"210679_X_AT","---","---","---","---","---","---","---","unknown",7.5596,1,0,-6,-0.5277,0.2235]
[26,14,"57739_AT","DND1 /// LOC644157 /// LOC644256","dead end homolog 1 (zebrafish) /// similar to dead end homolog 1","---","---","multicellular organismal development","nucleotide binding /// nucleic acid binding /// RNA binding","---",null,6.968,1,0,-6,-0.8311,0.0205]
[26,15,"212021_S_AT","MKI67","antigen identified by monoclonal antibody Ki-67","---","---","regulation of progression through cell cycle /// cell cycle /// cell proliferation","nucleotide binding /// protein binding /// ATP binding","nucleolus","cell cycle,proliferation",1.6036,1,1.704,-2,-0.6542,0.1109]
[26,16,"211630_S_AT","GSS","glutathione synthetase","---","---","amino acid metabolic process /// glutathione biosynthetic process /// response to oxidative stress /// nervous system development","nucleotide binding /// catalytic activity /// glutathione synthase activity /// glutathione synthase activity /// ATP binding /// ligase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",0.11,1,0,-6,0.4575,0.302]
[26,17,"203182_S_AT","SRPK2","SFRS protein kinase 2","mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","spliceosome assembly /// mRNA processing /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// protein kinase cascade /// RNA splicing /// RNA splicing /// cell differentiation","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// ATP binding /// kinase activity /// transferase activity","nucleus /// cytoplasm /// cytoplasm","cell growth,differentiation",1.4079,-1,0,-6,-0.9314,0.0023]
[26,18,"64064_AT","GIMAP5","GTPase, IMAP family member 5","---","---","---","nucleotide binding /// GTP binding","mitochondrion /// membrane /// integral to membrane /// outer membrane","unknown",4.0681,1,0,-6,-0.3523,0.4384]
[26,19,"203145_AT","SPAG5","sperm associated antigen 5","---","---","cell cycle /// cell cycle /// spindle organization and biogenesis /// mitosis /// phosphoinositide-mediated signaling /// cell division","---","cytoplasm /// microtubule /// spindle microtubule","cell cycle,proliferation",4.5895,1,0,-2,-0.6507,0.1135]
[26,20,"218252_AT","CKAP2","cytoskeleton associated protein 2","---","---","apoptosis /// cell cycle","---","cytoplasm /// microtubule","apoptosis:cell cycle,proliferation",9.7442,1,0,-4,-0.8226,0.0231]
[26,21,"205043_AT","CFTR","cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)","---","---","transport /// transport /// ion transport /// respiratory gaseous exchange","nucleotide binding /// ion channel activity /// ATP-binding and phosphorylation-dependent chloride channel activity /// chloride channel activity /// chloride channel activity /// channel-conductance-controlling ATPase activity /// protein binding /// ATP binding /// ATP binding /// ATPase activity /// nucleoside-triphosphatase activity /// PDZ domain binding /// chloride ion binding /// ATPase activity, coupled to transmembrane movement of substances","membrane /// integral to membrane /// basolateral plasma membrane /// apical plasma membrane","transport,ion channel",1.7426,1,1.6595,-4,-0.01,0.983]
[26,22,"204923_AT","CXorf9","chromosome X open reading frame 9","---","---","---","---","---","unknown",5.0973,-1,0,-4,-0.8775,0.0094]
[26,23,"213226_AT","CCNA2","cyclin A2","Cell_cycle_KEGG /// DNA_replication_Reactome /// DNA_replication_Reactome /// Proteasome_Degradation /// Ribosomal_Proteins /// Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/cellular_process-GenMAPP/Mm_DNA_replication_Reactome/Mm_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/molecular_function_GenMAPP/Rn_Ribosomal_Proteins/Rn_Ribosomal_Proteins.htm","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// protein modification process /// cell cycle /// cell cycle /// mitosis /// mitotic cell cycle G2/M transition DNA damage checkpoint /// axon guidance /// protein ubiquitination /// ER-associated protein catabolic process /// long-term strengthening of neuromuscular junction /// proteasomal ubiquitin-dependent protein catabolic process /// positive regulation of transcription /// positive regulation of transcription /// regulation of synaptic plasticity /// cell division","protein binding /// transcription regulator activity","female pronucleus /// male pronucleus /// nucleus /// nucleus /// nucleus /// cytoplasm","dna repair,transcription:cell cycle,proliferation",5.228,1,0,-6,-0.9058,0.005]
[26,24,"218805_AT","GIMAP5","GTPase, IMAP family member 5","---","---","---","nucleotide binding /// GTP binding","mitochondrion /// membrane /// integral to membrane /// outer membrane","unknown",1.7907,1,1.9064,-6,-0.4229,0.3445]
[26,25,"222077_S_AT","RACGAP1","Rac GTPase activating protein 1","S1P_Signaling /// S1P_Signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_S1P_Signaling/Hs_S1P_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_S1P_Signaling/Hs_S1P_Signaling.htm","cytokinesis /// cytokinesis, contractile ring formation /// cell cycle /// cytokinesis, initiation of separation /// signal transduction /// intracellular signaling cascade /// spermatogenesis /// neuroblast proliferation /// neuroblast proliferation /// embryonic development /// embryonic development /// cell division","GTPase activator activity /// GTPase activator activity /// protein binding /// zinc ion binding /// diacylglycerol binding /// alpha-tubulin binding /// gamma-tubulin binding /// metal ion binding /// beta-tubulin binding","intracellular /// nucleus /// cytoplasm /// microtubule","cell cycle,proliferation:signal transduction,signaling pathway",7.0893,1,0,-6,-0.9234,0.003]
[26,26,"209714_S_AT","CDKN3","cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)","---","---","regulation of cyclin-dependent protein kinase activity /// G1/S transition of mitotic cell cycle /// cell cycle /// cell cycle arrest /// negative regulation of cell proliferation /// dephosphorylation","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein binding /// protein tyrosine/serine/threonine phosphatase activity /// kinase activity /// hydrolase activity /// phosphoric monoester hydrolase activity","---","cell cycle,proliferation",3.4984,-1,0,-2,-0.9869,0]
[26,27,"221520_S_AT","CDCA8","cell division cycle associated 8","---","---","cell cycle /// mitosis /// cell division","protein binding","chromosome, pericentric region /// chromosome /// cytoplasm /// protein complex","cell cycle,proliferation",8.3153,-1,0,0,-0.8912,0.0071]
[26,28,"218662_S_AT","NCAPG","non-SMC condensin I complex, subunit G","---","---","cell cycle /// mitosis /// mitotic chromosome condensation /// mitotic chromosome condensation /// cell division","protein binding","nucleus /// cytoplasm","cell cycle,proliferation",1.8381,1,1.9027,-6,-0.6278,0.1311]
[26,29,"218308_AT","TACC3","transforming, acidic coiled-coil containing protein 3","---","---","regulation of progression through cell cycle /// response to stress /// hemopoiesis /// cytoplasmic sequestering of transcription factor","---","cytoplasm","dna repair,transcription:cell cycle,proliferation",9.2847,1,0,-4,-0.599,0.1553]
[26,30,"219918_S_AT","ASPM","asp (abnormal spindle) homolog, microcephaly associated (Drosophila)","---","---","cell cycle /// mitosis /// cell division","calmodulin binding","cytoplasm","cell cycle,proliferation",7.0657,-1,0,-4,-0.9291,0.0025]
[26,31,"219148_AT","PBK","PDZ binding kinase","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// mitosis","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// ATP binding /// kinase activity /// transferase activity","---",null,5.7483,1,0,-6,-0.7105,0.0736]
[26,32,"218726_AT","DKFZp762E1312","hypothetical protein DKFZp762E1312","---","---","---","---","---","unknown",8.0927,1,0,0,-0.5806,0.1717]
[26,33,"205831_AT","CD2","CD2 molecule","---","---","lipid raft polarization /// induction of apoptosis /// cell adhesion /// cell surface receptor linked signal transduction /// cell-cell adhesion /// natural killer cell activation /// positive regulation of myeloid dendritic cell activation /// T cell activation /// regulation of T cell differentiation","receptor activity /// receptor activity /// protein binding /// protein binding /// protein binding","integral to plasma membrane /// membrane /// integral to membrane","cell growth,differentiation:cell adhesion:apoptosis:signal transduction,signaling pathway",6.5564,1,0,0,-0.6634,0.1042]
[26,34,"207828_S_AT","CENPF","centromere protein F, 350/400ka (mitosin)","---","---","G2 phase of mitotic cell cycle /// M phase of mitotic cell cycle /// M phase of mitotic cell cycle /// mitotic cell cycle /// cell cycle /// chromosome segregation /// chromosome segregation /// mitosis /// mitotic cell cycle spindle assembly checkpoint /// cell proliferation /// regulation of striated muscle development /// negative regulation of transcription /// response to drug /// cell division /// metaphase plate congression /// kinetochore assembly","chromatin binding /// protein binding /// protein C-terminus binding /// transcription factor binding /// protein homodimerization activity /// dynein binding /// protein heterodimerization activity","chromosome, pericentric region /// chromosome, pericentric region /// kinetochore /// chromatin /// spindle pole /// outer kinetochore of condensed chromosome /// outer kinetochore of condensed chromosome /// nucleus /// nuclear envelope /// chromosome /// cytoplasm /// nuclear matrix","dna repair,transcription:cell cycle,proliferation",7.4414,-1,0,0,-0.8887,0.0075]
[26,35,"204826_AT","CCNF","cyclin F","---","---","regulation of progression through cell cycle /// regulation of progression through cell cycle /// re-entry into mitotic cell cycle /// placenta development /// cell cycle /// mitosis /// cell division","protein binding","nucleus","cell cycle,proliferation",7.0414,1,0,0,-0.6594,0.1071]
[26,36,"212815_AT","ASCC3","activating signal cointegrator 1 complex subunit 3","---","---","transcription /// regulation of transcription, DNA-dependent","nucleotide binding /// nucleic acid binding /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity /// nucleoside-triphosphatase activity","intracellular /// cytoplasm","dna repair,transcription",36.0891,1,0,0,0.3651,0.4207]
[26,37,"208079_S_AT","AURKA","aurora kinase A","---","---","mitotic cell cycle /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// cell cycle /// cell cycle /// spindle organization and biogenesis /// mitosis /// regulation of protein stability /// phosphoinositide-mediated signaling","nucleotide binding /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// protein binding /// ATP binding /// kinase activity /// transferase activity /// ubiquitin protein ligase binding","nucleus /// spindle","cell cycle,proliferation",20.4925,1,0,0,-0.8488,0.0157]
[]
[null,null,27]
[27,1,"205569_AT","LAMP3","lysosomal-associated membrane protein 3","---","---","cell proliferation","---","lysosome /// lysosomal membrane /// lysosomal membrane /// membrane /// integral to membrane","cell cycle,proliferation",2.4068,-1,0,0,0.5024,0.2506]
[27,2,"213238_AT","ATP10D","ATPase, Class V, type 10D","---","---","transport /// cation transport /// phospholipid transport","nucleotide binding /// magnesium ion binding /// magnesium ion binding /// phospholipid-translocating ATPase activity /// phospholipid-translocating ATPase activity /// ATP binding /// ATP binding /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// metal ion binding","membrane /// integral to membrane /// integral to membrane","transport,ion channel",2.5255,1,0,0,-0.4289,0.337]
[27,3,"214723_X_AT","KIAA1641","KIAA1641","---","---","---","---","---","unknown",8.3543,1,0,-2,-0.6676,0.1013]
[27,4,"213906_AT","MYBL1","v-myb myeloblastosis viral oncogene homolog (avian)-like 1","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// regulation of transcription","DNA binding /// transcription activator activity /// transcription regulator activity","nucleus /// nucleus","dna repair,transcription",3.5355,1,0,0,-0.1724,0.7116]
[27,5,"208579_X_AT","H2BFS","H2B histone family, member S","---","---","nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// defense response to bacterium","DNA binding","nucleosome /// nucleus /// chromosome",null,5.5599,1,0,-2,-0.5289,0.2223]
[27,6,"208546_X_AT","HIST1H2BH","histone cluster 1, H2bh","---","---","nucleosome assembly /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota)","DNA binding /// DNA binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,5.0695,1,0,-2,-0.579,0.1731]
[27,7,"214522_X_AT","HIST1H3D","histone cluster 1, H3d","---","---","nucleosome assembly /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// chromosome organization and biogenesis (sensu Eukaryota)","DNA binding /// DNA binding /// protein binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,2.1977,1,0,0,-0.3457,0.4475]
[27,8,"213186_AT","DZIP3","zinc finger DAZ interacting protein 3","---","---","protein polyubiquitination /// ubiquitin cycle","RNA binding /// RNA binding /// ubiquitin-protein ligase activity /// protein binding /// zinc ion binding /// ligase activity /// polyubiquitin binding /// metal ion binding","cytoplasm /// cytoplasm",null,5.5184,1,0,0,-0.6885,0.0872]
[27,9,"208478_S_AT","BAX","BCL2-associated X protein","Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","B cell apoptosis /// B cell apoptosis /// release of cytochrome c from mitochondria /// DNA fragmentation during apoptosis /// apoptosis /// induction of apoptosis /// induction of apoptosis /// induction of apoptosis /// induction of apoptosis /// caspase activation /// caspase activation /// cleavage of lamin /// transformed cell apoptosis /// cell cycle /// germ cell development /// mitochondrial fusion /// induction of apoptosis by extracellular signals /// induction of apoptosis by extracellular signals /// induction of apoptosis by intracellular signals /// negative regulation of survival gene product activity /// negative regulation of survival gene product activity /// caspase activation via cytochrome c /// apoptotic mitochondrial changes /// apoptotic mitochondrial changes /// response to toxin /// establishment and/or maintenance of transmembrane electrochemical gradient /// nuclear fragmentation during apoptosis /// release of matrix enzymes from mitochondria /// regulation of apoptosis /// regulation of protein homodimerization /// regulation of protein heterodimerization /// positive regulation of neuron apoptosis /// mitochondrial fragmentation during apoptosis /// negative regulation of progression through cell cycle /// induction of retinal programmed cell death /// protein homooligomerization /// regulation of mitochondrial membrane potential","protein binding /// protein binding /// lipid binding /// protein homodimerization activity /// protein homodimerization activity /// protein heterodimerization activity /// BH3 domain binding","cytoplasm /// mitochondrion /// mitochondrial permeability transition pore complex /// endoplasmic reticulum /// endoplasmic reticulum membrane /// cytosol /// membrane /// integral to membrane","apoptosis:cell cycle,proliferation",2.3018,1,0,2,0.0334,0.9433]
[27,10,"208475_AT","FRMD4A","FERM domain containing 4A","---","---","---","binding /// cytoskeletal protein binding","cytoplasm /// cytoskeleton /// extrinsic to membrane","unknown",2.2273,-1,0,-6,0.2594,0.5743]
[27,11,"211833_S_AT","BAX","BCL2-associated X protein","Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_GenMAPP /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","B cell apoptosis /// B cell apoptosis /// release of cytochrome c from mitochondria /// DNA fragmentation during apoptosis /// apoptosis /// induction of apoptosis /// induction of apoptosis /// induction of apoptosis /// induction of apoptosis /// caspase activation /// caspase activation /// cleavage of lamin /// transformed cell apoptosis /// cell cycle /// germ cell development /// mitochondrial fusion /// induction of apoptosis by extracellular signals /// induction of apoptosis by extracellular signals /// induction of apoptosis by intracellular signals /// negative regulation of survival gene product activity /// negative regulation of survival gene product activity /// caspase activation via cytochrome c /// apoptotic mitochondrial changes /// apoptotic mitochondrial changes /// response to toxin /// establishment and/or maintenance of transmembrane electrochemical gradient /// nuclear fragmentation during apoptosis /// release of matrix enzymes from mitochondria /// regulation of apoptosis /// regulation of protein homodimerization /// regulation of protein heterodimerization /// positive regulation of neuron apoptosis /// mitochondrial fragmentation during apoptosis /// negative regulation of progression through cell cycle /// induction of retinal programmed cell death /// protein homooligomerization /// regulation of mitochondrial membrane potential","protein binding /// protein binding /// lipid binding /// protein homodimerization activity /// protein homodimerization activity /// protein heterodimerization activity /// BH3 domain binding","cytoplasm /// mitochondrion /// mitochondrial permeability transition pore complex /// endoplasmic reticulum /// endoplasmic reticulum membrane /// cytosol /// membrane /// integral to membrane","apoptosis:cell cycle,proliferation",3.1688,-1,0,-2,-0.0663,0.8878]
[27,12,"207084_AT","POU3F2","POU class 3 homeobox 2","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// positive regulation of cell proliferation /// regulation of transcription /// regulation of cell differentiation","DNA binding /// transcription factor activity /// transcription factor activity /// sequence-specific DNA binding","nucleus","dna repair,transcription:cell growth,differentiation:cell cycle,proliferation",12.3655,1,1.2898,-2,-0.5597,0.1914]
[27,13,"214472_AT","HIST1H3D","histone cluster 1, H3d","---","---","nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota)","DNA binding /// protein binding","nucleosome /// nucleus /// chromosome",null,7.5442,1,0,-4,-0.4975,0.256]
[27,14,"210387_AT","HIST1H2BG","histone cluster 1, H2bg","---","---","nucleosome assembly /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// defense response to bacterium","DNA binding /// DNA binding /// protein binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,2.239,1,0,2,-0.2001,0.6671]
[27,15,"208046_AT","HIST1H4A","histone cluster 1, H4a","---","---","establishment and/or maintenance of chromatin architecture /// nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// phosphoinositide-mediated signaling","DNA binding /// DNA binding /// protein binding","nucleosome /// nucleosome /// nucleus /// chromosome",null,4.5092,1,0,4,-0.2897,0.5285]
[27,16,"206337_AT","CCR7","chemokine (C-C motif) receptor 7","GPCRDB_Class_A_Rhodopsin-like /// Peptide_GPCRs","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Class_A_Rhodopsin-like/Hs_GPCRDB_Class_A_Rhodopsin-like.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Peptide_GPCRs/Hs_Peptide_GPCRs.htm","chemotaxis /// inflammatory response /// signal transduction /// G-protein coupled receptor protein signaling pathway /// elevation of cytosolic calcium ion concentration","rhodopsin-like receptor activity /// signal transducer activity /// receptor activity /// G-protein coupled receptor activity /// G-protein coupled receptor activity /// chemokine receptor activity /// C-C chemokine receptor activity","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","signal transduction,signaling pathway",1.2735,1,0.0009,0,0.2385,0.6065]
[27,17,"214481_AT","HIST1H2AM","Histone cluster 1, H2am","---","---","nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota)","DNA binding","nucleosome /// nucleus /// chromosome",null,5.1428,1,0,-4,-0.2458,0.5952]
[]
[null,null,28]
[28,1,"202303_X_AT","SMARCA5","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5","---","---","nucleosome assembly /// chromatin remodeling /// chromatin remodeling /// transcription initiation /// regulation of transcription from RNA polymerase II promoter /// chromatin modification /// nucleosome positioning","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA binding /// RNA polymerase II transcription factor activity /// helicase activity /// helicase activity /// protein binding /// ATP binding /// ATP binding /// hydrolase activity /// ATPase activity /// histone binding","condensed chromosome /// nucleus /// nucleus /// nucleoplasm /// RSF complex","dna repair,transcription",2.2479,-1,1.6254,1,-0.5731,0.1787]
[28,2,"218131_S_AT","GATAD2A","GATA zinc finger domain containing 2A","---","---","DNA methylation /// transcription /// regulation of transcription, DNA-dependent /// negative regulation of transcription, DNA-dependent /// negative regulation of transcription, DNA-dependent","transcription factor activity /// protein binding /// protein binding /// zinc ion binding /// transcription repressor activity /// transcription repressor activity /// protein binding, bridging /// protein binding, bridging /// sequence-specific DNA binding /// metal ion binding","nucleus /// nucleus /// nucleus /// NuRD complex /// NuRD complex","dna repair,transcription",1.141,-1,1.1534,-3,-0.0535,0.9093]
[28,3,"221829_S_AT","TNPO1","transportin 1","---","---","protein import into nucleus, docking /// protein import into nucleus, translocation /// transport /// intracellular protein transport /// protein transport","binding /// protein binding /// nuclear localization sequence binding /// protein transporter activity","nucleus /// nucleus /// nuclear pore /// cytoplasm /// cytoplasm","transport,ion channel",9.9269,-1,0,-3,-0.579,0.1731]
[28,4,"209511_AT","POLR2F","polymerase (RNA) II (DNA directed) polypeptide F","RNA_transcription_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_RNA_transcription_Reactome/Hs_RNA_transcription_Reactome.htm","transcription /// transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// regulation of transcription","DNA binding /// DNA-directed RNA polymerase activity","RNA polymerase complex","dna repair,transcription",5.1498,-1,1.8351,-1,0.4987,0.2547]
[28,5,"202804_AT","ABCC1","ATP-binding cassette, sub-family C (CFTR/MRP), member 1","Irinotecan_pathway_PharmGKB /// Irinotecan_pathway_PharmGKB","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Irinotecan_pathway_PharmGKB/Hs_Irinotecan_pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Irinotecan_pathway_PharmGKB/Hs_Irinotecan_pathway_PharmGKB.htm","transport /// transport /// response to drug","nucleotide binding /// transporter activity /// transporter activity /// ATP binding /// ATP binding /// ATPase activity /// ATPase activity /// nucleoside-triphosphatase activity /// ATPase activity, coupled to transmembrane movement of substances /// ATPase activity, coupled to transmembrane movement of substances","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane","transport,ion channel",4.6652,1,0,0,0.6201,0.1374]
[28,6,"211615_S_AT","LRPPRC","leucine-rich PPR-motif containing","---","---","transcription /// regulation of transcription, DNA-dependent /// transport /// mitochondrion transport along microtubule /// mRNA transport","DNA binding /// single-stranded DNA binding /// RNA binding /// RNA binding /// binding /// protein binding /// microtubule binding /// beta-tubulin binding /// actin filament binding","condensed nuclear chromosome /// nucleus /// nucleus /// cytoplasm /// mitochondrion /// mitochondrion /// mitochondrion /// cytoskeleton /// membrane /// perinuclear region of cytoplasm","dna repair,transcription:transport,ion channel",1.6042,-1,0,-1,0.0943,0.8405]
[28,7,"201023_AT","TAF7","TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa","RNA_transcription_Reactome /// RNA_transcription_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_RNA_transcription_Reactome/Hs_RNA_transcription_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_RNA_transcription_Reactome/Hs_RNA_transcription_Reactome.htm","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// estrogen receptor signaling pathway /// regulation of transcription","transcription factor activity /// RNA polymerase II transcription factor activity /// transcription coactivator activity /// protein binding /// general RNA polymerase II transcription factor activity","nucleus /// transcription factor TFIID complex /// transcription factor TFIID complex","dna repair,transcription:signal transduction,signaling pathway",4.008,-1,1.3681,0,-0.4441,0.3182]
[28,8,"218732_AT","PTRH2","peptidyl-tRNA hydrolase 2","---","---","apoptosis /// regulation of transcription","DNA binding /// aminoacyl-tRNA hydrolase activity /// hydrolase activity","chromosome, pericentric region /// nucleus /// mitochondrion","dna repair,transcription:apoptosis",1.0112,-1,1.4943,1,0.1904,0.6827]
[28,9,"212175_S_AT","AK2","adenylate kinase 2","---","---","nucleobase, nucleoside, nucleotide and nucleic acid metabolic process","nucleotide binding /// adenylate kinase activity /// adenylate kinase activity /// ATP binding /// kinase activity /// transferase activity /// phosphotransferase activity, phosphate group as acceptor /// nucleotide kinase activity /// nucleoside kinase activity","mitochondrion /// mitochondrial inner membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",0.685,-1,0,1,-0.0708,0.8801]
[28,10,"201804_X_AT","TBCB","tubulin folding cofactor B","---","---","protein folding /// multicellular organismal development /// nervous system development /// cell differentiation","protein binding","cytoplasm /// cytoskeleton /// microtubule /// microtubule cytoskeleton","cell growth,differentiation",2.7736,-1,0,-1,0.0442,0.925]
[28,11,"217776_AT","RDH11","retinol dehydrogenase 11 (all-trans/9-cis/11-cis)","---","---","metabolic process /// retinol metabolic process","retinol dehydrogenase activity /// oxidoreductase activity","intracellular /// endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",3.1457,-1,0,-2,0.1762,0.7055]
[28,12,"201379_S_AT","TPD52L2","tumor protein D52-like 2","---","---","---","protein binding","---","unknown",5.134,-1,0,-2,0.1342,0.7742]
[28,13,"202138_X_AT","JTV1","JTV1 gene","---","---","translation","damaged DNA binding","---",null,1.6462,-1,0,-3,0.0508,0.9139]
[28,14,"201410_AT","PLEKHB2","pleckstrin homology domain containing, family B (evectins) member 2","---","---","---","protein binding","membrane","unknown",0.9509,-1,1.2184,-1,-0.3998,0.3743]
[28,15,"212018_S_AT","RSL1D1","ribosomal L1 domain containing 1","---","---","translation","structural constituent of ribosome /// protein binding","intracellular /// ribosome",null,0.8322,-1,0.9379,-1,0.0306,0.9481]
[28,16,"202696_AT","OXSR1","oxidative-stress responsive 1","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// response to oxidative stress /// response to oxidative stress /// protein kinase cascade","nucleotide binding /// magnesium ion binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// protein binding /// ATP binding /// ATP binding /// kinase activity /// transferase activity /// identical protein binding /// metal ion binding","---",null,1.291,-1,0,-3,-0.1491,0.7497]
[28,17,"209025_S_AT","SYNCRIP","synaptotagmin binding, cytoplasmic RNA interacting protein","---","---","RNA processing /// mRNA processing /// RNA splicing /// RNA splicing","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// protein binding /// poly(A) binding","nucleus /// spliceosome /// cytoplasm /// endoplasmic reticulum /// microsome /// ribonucleoprotein complex /// ribonucleoprotein complex",null,6.2986,-1,1.5305,-2,-0.1961,0.6735]
[28,18,"202097_AT","NUP153","nucleoporin 153kDa","---","---","protein targeting /// transport /// protein transport /// ATP synthesis coupled proton transport /// mRNA transport","DNA binding /// transporter activity /// protein binding /// ATP binding /// zinc ion binding /// porin activity /// metal ion binding /// hydrogen ion transporting ATP synthase activity, rotational mechanism /// hydrogen ion transporting ATPase activity, rotational mechanism","intracellular /// nuclear pore /// nuclear pore /// integral to membrane /// proton-transporting two-sector ATPase complex /// outer membrane","transport,ion channel",0.9562,-1,1.2509,-2,0.1178,0.8013]
[28,19,"203007_X_AT","LYPLA1","lysophospholipase I","---","---","lipid metabolic process /// fatty acid metabolic process","lysophospholipase activity /// hydrolase activity","membrane fraction /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",4.2022,-1,0,-1,-0.2771,0.5474]
[28,20,"212846_AT","RRP1B","ribosomal RNA processing 1 homolog B (S. cerevisiae)","---","---","rRNA processing","protein binding","nucleus /// cytosol /// nucleolar preribosome, small subunit precursor",null,0.8364,-1,1.7563,0,-0.4555,0.3043]
[28,21,"201573_S_AT","ETF1","eukaryotic translation termination factor 1","Translation_Factors /// Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational termination /// regulation of translational termination","RNA binding /// translation release factor activity /// protein binding /// translation termination factor activity /// translation release factor activity, codon specific /// ribosome binding","cytoplasm /// cytoplasm",null,3.9556,-1,1.9042,-1,0.0287,0.9513]
[28,22,"208066_S_AT","GTF2B","general transcription factor IIB","RNA_transcription_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_RNA_transcription_Reactome/Hs_RNA_transcription_Reactome.htm","transcription /// transcription initiation /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// regulation of transcription","protein binding /// zinc ion binding /// general RNA polymerase II transcription factor activity /// transcription regulator activity /// metal ion binding","transcription factor complex","dna repair,transcription",4.5054,1,0,-1,0.7836,0.0371]
[28,23,"200837_AT","BCAP31","B-cell receptor-associated protein 31","---","---","transport /// intracellular protein transport /// ER to Golgi vesicle-mediated transport /// apoptosis /// immune response /// immune response /// protein transport","receptor activity /// receptor binding /// protein binding","Golgi membrane /// endoplasmic reticulum /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","transport,ion channel:apoptosis:immune response",2.8463,-1,1.6194,-2,-0.262,0.5703]
[28,24,"202218_S_AT","FADS2","fatty acid desaturase 2","---","---","lipid metabolic process /// fatty acid biosynthetic process /// unsaturated fatty acid biosynthetic process","iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water /// heme binding /// metal ion binding /// transition metal ion binding","membrane fraction /// integral to plasma membrane /// membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",3.95,1,0.0003,0,0.3642,0.4219]
[28,25,"201487_AT","CTSC","cathepsin C","---","---","proteolysis /// immune response","cysteine-type endopeptidase activity /// dipeptidyl-peptidase I activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity /// chloride ion binding","lysosome /// lysosome","immune response:proteolysis",3.3068,-1,0,-2,-0.1843,0.6924]
[28,26,"212250_AT","MTDH","metadherin","---","---","---","---","endoplasmic reticulum /// tight junction /// membrane /// integral to membrane /// cell junction","unknown",7.0401,-1,1.0539,1,-0.3231,0.4797]
[28,27,"201097_S_AT","ARF4","ADP-ribosylation factor 4","---","---","transport /// ER to Golgi vesicle-mediated transport /// small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTPase activity /// GTP binding /// enzyme activator activity","intracellular /// cytoplasm /// plasma membrane","transport,ion channel:signal transduction,signaling pathway",4.134,-1,1.6843,-2,-0.0744,0.874]
[28,28,"209787_S_AT","HMGN4","high mobility group nucleosomal binding domain 4","---","---","---","DNA binding","chromatin /// nucleus","unknown",2.5301,-1,1.4652,-1,-0.7378,0.0583]
[28,29,"211725_S_AT","BID","BH3 interacting domain death agonist","Apoptosis /// Apoptosis_GenMAPP","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm","release of cytochrome c from mitochondria /// apoptosis /// induction of apoptosis via death domain receptors /// apoptotic mitochondrial changes /// regulation of apoptosis /// positive regulation of apoptosis /// neuron apoptosis","carboxylesterase activity /// death receptor binding /// protein binding /// protein binding /// hydrolase activity /// S-formylglutathione hydrolase activity","membrane fraction /// cytoplasm /// mitochondrion /// mitochondrion /// cytosol /// membrane /// cytoplasmic membrane-bound vesicle /// cytoplasmic vesicle","apoptosis",2.5805,-1,0,1,0.0957,0.8382]
[28,30,"222288_AT","---","Transcribed locus, moderately similar to XP_517655.1  similar to KIAA0825 protein [Pan troglodytes]","---","---","---","---","---","unknown",13.0156,-1,0,1,-0.7764,0.0401]
[28,31,"201923_AT","PRDX4","peroxiredoxin 4","---","---","I-kappaB phosphorylation","peroxidase activity /// thioredoxin peroxidase activity /// antioxidant activity /// oxidoreductase activity /// peroxiredoxin activity","cytoplasm",null,4.1214,-1,0,-2,0.1185,0.8002]
[28,32,"202779_S_AT","LOC731049 /// UBE2S","ubiquitin-conjugating enzyme E2S /// similar to Ubiquitin-conjugating enzyme E2S (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (E2-EPF5)","---","---","protein modification process /// protein modification process /// ubiquitin cycle","ubiquitin-protein ligase activity /// ligase activity /// small conjugating protein ligase activity","---",null,7.0137,-1,0.3045,-1,-0.5983,0.1558]
[28,33,"218336_AT","PFDN2","prefoldin subunit 2","---","---","protein folding /// protein folding","protein binding /// unfolded protein binding /// unfolded protein binding","prefoldin complex /// prefoldin complex",null,3.2279,-1,1.8332,-1,0.0497,0.9157]
[28,34,"217986_S_AT","BAZ1A","bromodomain adjacent to zinc finger domain, 1A","---","---","transcription /// regulation of transcription, DNA-dependent","protein binding /// zinc ion binding /// metal ion binding","---","dna repair,transcription",5.2369,-1,1.4109,-1,-0.2902,0.5279]
[28,35,"214214_S_AT","C1QBP","complement component 1, q subcomponent binding protein","---","---","immune response","protein binding","mitochondrion /// mitochondrial matrix /// plasma membrane /// membrane","immune response",4.3569,-1,0,-1,-0.0456,0.9227]
[28,36,"218334_AT","THOC7","THO complex 7 homolog (Drosophila)","---","---","---","---","---","unknown",3.0758,-1,1.5465,1,-0.2391,0.6057]
[28,37,"219158_S_AT","NARG1","NMDA receptor regulated 1","Electron_Transport_Chain","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Electron_Transport_Chain/Hs_Electron_Transport_Chain.htm","angiogenesis /// transcription /// regulation of transcription, DNA-dependent /// N-terminal protein amino acid acetylation /// multicellular organismal development /// cell differentiation /// positive regulation of transcription, DNA-dependent","binding /// protein binding /// N-acetyltransferase activity /// acetyltransferase activity /// ribosome binding","nucleus /// transcription factor complex /// cytoplasm /// cytoplasm","dna repair,transcription:cell growth,differentiation",9.4073,-1,1.0927,-2,-0.4239,0.3432]
[28,38,"212279_AT","TMEM97","transmembrane protein 97","---","---","regulation of cell growth","---","membrane /// integral to membrane","cell growth,differentiation",3.6315,-1,0,-3,0.2748,0.551]
[28,39,"200648_S_AT","GLUL","glutamate-ammonia ligase (glutamine synthetase)","---","---","regulation of neurotransmitter levels /// glutamine biosynthetic process /// nitrogen compound metabolic process","catalytic activity /// glutamate-ammonia ligase activity /// ligase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",2.1355,-1,0,-2,-0.307,0.503]
[28,40,"205361_S_AT","PFDN4","prefoldin subunit 4","---","---","protein folding /// chaperonin-mediated tubulin folding","unfolded protein binding /// chaperone binding","cytosol /// prefoldin complex",null,10.1827,-1,1.28,-1,-0.2104,0.6507]
[28,41,"211475_S_AT","BAG1","BCL2-associated athanogene","Ribosomal_Proteins /// Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/molecular_function_GenMAPP/Rn_Ribosomal_Proteins/Rn_Ribosomal_Proteins.htm","translation /// translation /// protein folding /// protein modification process /// apoptosis /// anti-apoptosis /// cell surface receptor linked signal transduction","structural constituent of ribosome /// structural constituent of ribosome /// receptor signaling protein activity /// protein binding /// protein binding","intracellular /// nucleus /// cytoplasm /// cytoplasm /// ribosome /// ribosome /// membrane /// integral to membrane /// ribonucleoprotein complex /// protein complex","apoptosis:signal transduction,signaling pathway",4.0795,1,0,-2,0.7451,0.0546]
[28,42,"201595_S_AT","ZC3H15","zinc finger CCCH-type containing 15","---","---","---","nucleic acid binding /// zinc ion binding","---","unknown",3.7194,-1,1.4006,-2,-0.2088,0.6531]
[28,43,"206055_S_AT","SNRPA1","small nuclear ribonucleoprotein polypeptide A'","mRNA_processing_Reactome /// mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","nuclear mRNA splicing, via spliceosome /// mRNA processing /// RNA splicing /// RNA splicing","RNA binding /// protein binding /// protein binding","spliceosome /// spliceosome /// snRNP U2 /// ribonucleoprotein complex /// small nuclear ribonucleoprotein complex",null,4.909,-1,0,-2,0.1817,0.6966]
[28,44,"203612_AT","BYSL","bystin-like","---","---","cell adhesion /// female pregnancy /// ribosome biogenesis and assembly","---","cytoplasm /// cytoplasm","cell adhesion",5.0265,1,0,-1,0.6424,0.1197]
[28,45,"209814_AT","ZNF330","zinc finger protein 330","---","---","---","protein binding /// zinc ion binding /// metal ion binding /// metal ion binding","chromosome, pericentric region /// nucleus /// nucleolus /// midbody","unknown",3.1067,-1,0,-1,-0.1931,0.6783]
[28,46,"214722_AT","NOTCH2NL","Notch homolog 2 (Drosophila) N-terminal like","---","---","---","calcium ion binding","cytoplasm","unknown",2.9265,-1,1.3619,-1,-0.071,0.8797]
[28,47,"201873_S_AT","ABCE1 /// LOC647150","ATP-binding cassette, sub-family E (OABP), member 1 /// similar to ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)","---","---","electron transport /// RNA catabolic process /// protein folding /// response to virus","nucleotide binding /// ATP binding /// ribonuclease inhibitor activity /// electron carrier activity /// ATPase activity /// nucleoside-triphosphatase activity /// iron-sulfur cluster binding","cytoplasm /// cytoplasm /// mitochondrion /// mitochondrion","transport,ion channel",3.2968,-1,0,-1,0.0213,0.9639]
[28,48,"204616_AT","UCHL3","ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)","---","---","ubiquitin-dependent protein catabolic process /// ubiquitin-dependent protein catabolic process /// ubiquitin cycle","ubiquitin thiolesterase activity /// ubiquitin thiolesterase activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity","intracellular /// cytoplasm /// cytoplasm",null,5.0317,-1,0,-1,0.3196,0.4848]
[28,49,"209539_AT","ARHGEF6","Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6","---","---","apoptosis /// JNK cascade /// regulation of Rho protein signal transduction","guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity /// GTPase activator activity","intracellular /// intracellular","apoptosis:signal transduction,signaling pathway",1.3668,-1,0,-1,-0.9151,0.0039]
[28,50,"208985_S_AT","EIF3J","eukaryotic translation initiation factor 3, subunit J","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// regulation of translational initiation","translation initiation factor activity /// translation initiation factor activity /// protein binding","eukaryotic translation initiation factor 3 complex",null,4.1754,-1,1.5534,1,-0.1093,0.8155]
[28,51,"212588_AT","PTPRC","protein tyrosine phosphatase, receptor type, C","---","---","negative regulation of T cell mediated cytotoxicity /// negative regulation of cytokine and chemokine mediated signaling pathway /// negative regulation of protein kinase activity /// negative regulation of protein kinase activity /// protein amino acid dephosphorylation /// protein amino acid dephosphorylation /// cell surface receptor linked signal transduction /// dephosphorylation /// dephosphorylation /// T cell differentiation /// B cell proliferation /// positive regulation of T cell proliferation /// positive regulation of protein kinase activity /// T cell receptor signaling pathway /// T cell receptor signaling pathway /// B cell receptor signaling pathway /// positive regulation of antigen receptor-mediated signaling pathway /// release of sequestered calcium ion into cytosol /// defense response to virus /// regulation of cell cycle","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// receptor activity /// transmembrane receptor protein tyrosine phosphatase activity /// hydrolase activity /// phosphoric monoester hydrolase activity /// protein kinase binding /// protein kinase binding","integral to plasma membrane /// integral to plasma membrane /// focal adhesion /// membrane /// integral to membrane","cell growth,differentiation:cell cycle,proliferation:signal transduction,signaling pathway",15.2707,-1,0,-1,-0.8921,0.0069]
[28,52,"200921_S_AT","BTG1","B-cell translocation gene 1, anti-proliferative","Circadian_Exercise /// Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/physiological_process-GenMAPP/Mm_Circadian_Exercise/Mm_Circadian_Exercise.htm","negative regulation of cell proliferation /// cell migration /// negative regulation of cell growth /// regulation of apoptosis /// regulation of transcription /// positive regulation of endothelial cell differentiation /// positive regulation of myoblast differentiation /// positive regulation of angiogenesis","transcription cofactor activity /// protein binding /// enzyme binding /// kinase binding","nucleus /// nucleus /// cytoplasm","dna repair,transcription:cell growth,differentiation:apoptosis:cell cycle,proliferation",4.1603,1,0,-1,0.5606,0.1905]
[28,53,"218187_S_AT","C8orf33","chromosome 8 open reading frame 33","---","---","---","---","---","unknown",4.1805,-1,0,-1,0.3319,0.4671]
[28,54,"201802_AT","SLC29A1","solute carrier family 29 (nucleoside transporters), member 1","---","---","nucleobase, nucleoside, nucleotide and nucleic acid metabolic process /// transport /// nucleoside transport /// nucleoside transport","nucleoside transmembrane transporter activity /// nucleoside transmembrane transporter activity /// protein binding","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",4.3085,1,0,0,0.8428,0.0172]
[28,55,"204224_S_AT","GCH1","GTP cyclohydrolase 1 (dopa-responsive dystonia)","---","---","L-phenylalanine catabolic process /// tetrahydrobiopterin biosynthetic process /// nitric oxide biosynthetic process /// aromatic compound biosynthetic process /// neurotransmitter metabolic process","catalytic activity /// GTP cyclohydrolase I activity /// GTP cyclohydrolase I activity /// protein binding /// hydrolase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",4.9808,-1,0,0,0.3491,0.4429]
[28,56,"213671_S_AT","MARS","methionyl-tRNA synthetase","---","---","translation /// tRNA aminoacylation for protein translation /// methionyl-tRNA aminoacylation","tRNA binding /// nucleotide binding /// RNA binding /// aminoacyl-tRNA ligase activity /// methionine-tRNA ligase activity /// methionine-tRNA ligase activity /// protein binding /// ATP binding /// ligase activity","soluble fraction /// cytoplasm /// cytoplasm",null,3.5951,-1,0,0,0.362,0.4249]
[28,57,"218105_S_AT","MRPL4","mitochondrial ribosomal protein L4","---","---","translation","structural constituent of ribosome","intracellular /// mitochondrion /// ribosome /// ribonucleoprotein complex",null,5.4608,-1,0,0,0.0741,0.8745]
[28,58,"200862_AT","DHCR24","24-dehydrocholesterol reductase","---","---","electron transport /// steroid biosynthetic process /// cholesterol biosynthetic process /// cholesterol biosynthetic process /// cholesterol biosynthetic process /// cholesterol biosynthetic process /// apoptosis /// anti-apoptosis /// response to oxidative stress /// cell cycle arrest /// protein localization /// lipid biosynthetic process /// tissue development /// membrane organization and biogenesis /// sterol biosynthetic process /// male genitalia development /// plasminogen activation /// amyloid precursor protein catabolic process /// negative regulation of caspase activity /// neuroprotection /// skin development","oxidoreductase activity /// oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor /// enzyme binding /// peptide antigen binding","nucleus /// endoplasmic reticulum /// endoplasmic reticulum /// endoplasmic reticulum membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:apoptosis:cell cycle,proliferation",11.0321,1,0,0,0.3606,0.4268]
[28,59,"204285_S_AT","PMAIP1","phorbol-12-myristate-13-acetate-induced protein 1","---","---","release of cytochrome c from mitochondria /// induction of apoptosis /// caspase activation /// cell structure disassembly during apoptosis /// virus-infected cell apoptosis /// response to dsRNA","protein binding","mitochondrion","apoptosis",7.6149,-1,1.8987,0,0.2072,0.6558]
[28,60,"214011_S_AT","HSPC111","hypothetical protein HSPC111","---","---","---","---","---","unknown",4.1151,-1,0,0,0.0245,0.9584]
[28,61,"217850_AT","GNL3","guanine nucleotide binding protein-like 3 (nucleolar)","---","---","regulation of progression through cell cycle /// regulation of cell proliferation","nucleotide binding /// protein binding /// protein binding /// GTP binding /// GTP binding","intracellular /// nucleus /// nucleolus","cell cycle,proliferation",4.2014,-1,0,0,0.2553,0.5806]
[28,62,"221750_AT","HMGCS1","3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)","Cholesterol_Biosynthesis /// Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","acetyl-CoA metabolic process /// lipid metabolic process /// steroid biosynthetic process /// cholesterol biosynthetic process /// lipid biosynthetic process /// sterol biosynthetic process","hydroxymethylglutaryl-CoA synthase activity /// hydroxymethylglutaryl-CoA synthase activity /// transferase activity","soluble fraction /// cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",10.4349,-1,0,0,0.3926,0.3837]
[28,63,"201791_S_AT","DHCR7","7-dehydrocholesterol reductase","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","blood vessel development /// steroid biosynthetic process /// cholesterol biosynthetic process /// cholesterol biosynthetic process /// lipid biosynthetic process /// sterol biosynthetic process /// cell differentiation /// lung development /// regulation of cell proliferation","protein binding /// oxidoreductase activity /// 7-dehydrocholesterol reductase activity /// 7-dehydrocholesterol reductase activity","nuclear outer membrane /// endoplasmic reticulum /// endoplasmic reticulum /// membrane /// integral to membrane","cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",10.0832,1,0.0049,0,0.4504,0.3106]
[]
[null,null,29]
[29,1,"64942_AT","GPR153","G protein-coupled receptor 153","---","---","signal transduction /// G-protein coupled receptor protein signaling pathway","rhodopsin-like receptor activity /// signal transducer activity /// receptor activity /// G-protein coupled receptor activity","membrane /// integral to membrane","signal transduction,signaling pathway",2.4895,1,0,0,0.1201,0.7976]
[29,2,"33768_AT","DMWD","dystrophia myotonica, WD repeat containing","---","---","meiosis","---","---",null,9.0638,1,0,-3,0.3243,0.4779]
[29,3,"210039_S_AT","PRKCQ","protein kinase C, theta","Calcium_regulation_in_cardiac_cells /// G_Protein_Signaling /// Smooth_muscle_contraction /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","regulation of cell growth /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// intracellular signaling cascade /// intracellular signaling cascade /// positive regulation of T cell proliferation /// positive regulation of interleukin-2 biosynthetic process /// positive regulation of T cell activation /// activation of NF-kappaB transcription factor","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein kinase C activity /// protein binding /// ATP binding /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding","immunological synapse /// intracellular /// cytoplasm /// plasma membrane","dna repair,transcription:cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",15.3996,1,0,-1,-0.6021,0.1525]
[29,4,"203806_S_AT","FANCA","Fanconi anemia, complementation group A","---","---","DNA repair /// DNA repair /// protein complex assembly /// response to DNA damage stimulus","protein binding","nucleus /// cytoplasm /// cytoplasm","dna repair,transcription",2.5067,1,0,-3,0.6271,0.1317]
[29,5,"41856_AT","UNC5B","unc-5 homolog B (C. elegans)","---","---","apoptosis /// signal transduction /// multicellular organismal development","receptor activity /// protein binding","membrane /// integral to membrane","apoptosis:signal transduction,signaling pathway",15.311,-1,0,-1,0.2807,0.542]
[29,6,"208634_S_AT","MACF1","microtubule-actin crosslinking factor 1","---","---","mesoderm formation /// carbohydrate metabolic process /// posttranslational protein targeting to membrane /// cell motility /// cell cycle arrest /// establishment and/or maintenance of cell polarity /// Wnt receptor signaling pathway","actin binding /// actin binding /// hydrolase activity, hydrolyzing O-glycosyl compounds /// calcium ion binding /// calcium ion binding /// protein binding /// protein binding /// microtubule binding /// microtubule binding /// actin filament binding","cytoplasm /// cytoplasm /// cytoplasm /// cytoskeleton /// cytoskeleton /// actin cytoskeleton /// microtubule cytoskeleton","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",0.6219,1,1.2093,-1,0.2987,0.5152]
[29,7,"209721_S_AT","HOM-TES-103","hypothetical protein LOC25900","---","---","---","structural molecule activity","---","unknown",8.7546,1,0,-3,-0.3497,0.442]
[29,8,"212012_AT","PXDN","peroxidasin homolog (Drosophila)","---","---","immune response","peroxidase activity /// interleukin-1 receptor antagonist activity /// protein binding /// metal ion binding","---","immune response",9.9367,1,0,-1,-0.4949,0.2588]
[29,9,"221427_S_AT","CCNL2 /// LOC727877","cyclin L2 /// similar to Cyclin-L2 (Paneth cell-enhanced expression protein)","---","---","transcription /// regulation of transcription, DNA-dependent","---","---","dna repair,transcription",2.6929,1,0.0009,0,0.793,0.0334]
[29,10,"32811_AT","MYO1C","myosin IC","---","---","---","nucleotide binding /// motor activity /// actin binding /// protein binding /// calmodulin binding /// ATP binding","stress fiber /// cytoplasm /// microvillus /// basal plasma membrane /// lateral plasma membrane /// myosin complex /// unconventional myosin complex /// filamentous actin","unknown",6.4588,1,0,-3,0.2169,0.6404]
[29,11,"210647_X_AT","PLA2G6","phospholipase A2, group VI (cytosolic, calcium-independent)","Eicosanoid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Eicosanoid_Synthesis/Hs_Eicosanoid_Synthesis.htm","phospholipid metabolic process /// cell death /// lipid catabolic process","phospholipase A2 activity /// phospholipase A2 activity /// hydrolase activity","cytoplasm /// cytoplasm /// membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",6.7739,1,0,-3,0.466,0.2919]
[29,12,"205125_AT","PLCD1","phospholipase C, delta 1","Smooth_muscle_contraction /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","lipid metabolic process /// phospholipid metabolic process /// signal transduction /// intracellular signaling cascade /// lipid catabolic process","phosphoinositide phospholipase C activity /// phosphoinositide phospholipase C activity /// phospholipase C activity /// signal transducer activity /// calcium ion binding /// hydrolase activity /// metal ion binding","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway",7.0448,1,0,-3,0.3591,0.4289]
[29,13,"212144_AT","UNC84B","unc-84 homolog B (C. elegans)","---","---","nuclear membrane organization and biogenesis /// mitotic spindle organization and biogenesis /// nuclear migration","microtubule binding","nuclear envelope /// nuclear envelope /// endosome /// membrane /// integral to membrane",null,13.0183,-1,0,-1,-0.7566,0.049]
[29,14,"213520_AT","RECQL4","RecQ protein-like 4","---","---","DNA repair /// DNA recombination /// multicellular organismal development","nucleotide binding /// nucleic acid binding /// DNA helicase activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// zinc ion binding /// hydrolase activity","cytoplasm","dna repair,transcription",3.2939,1,0,-3,0.1501,0.7481]
[29,15,"222131_X_AT","RHOT2","ras homolog gene family, member T2","---","---","apoptosis /// small GTPase mediated signal transduction /// cellular homeostasis /// mitochondrion transport along microtubule","nucleotide binding /// calcium ion binding /// GTP binding /// hydrolase activity","intracellular /// mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane /// outer membrane /// integral to mitochondrial outer membrane","transport,ion channel:apoptosis:signal transduction,signaling pathway",7.9584,1,0,-1,-0.0093,0.9842]
[29,16,"221073_S_AT","NOD1","nucleotide-binding oligomerization domain containing 1","---","---","apoptosis /// apoptosis /// defense response /// inflammatory response /// signal transduction /// intracellular signaling cascade /// detection of biotic stimulus /// detection of bacterium /// interleukin-8 biosynthetic process /// defense response to bacterium /// regulation of apoptosis /// positive regulation of I-kappaB kinase/NF-kappaB cascade /// protein oligomerization","nucleotide binding /// signal transducer activity /// protein binding /// protein binding /// ATP binding /// caspase activator activity /// peptidoglycan binding","intracellular /// cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:signal transduction,signaling pathway",4.4941,1,1.4781,-3,0.3983,0.3762]
[29,17,"202307_S_AT","TAP1","transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)","DNA_replication_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","transcription /// translation /// transport /// oligopeptide transport /// defense response /// defense response /// immune response /// protein transport /// peptide transport /// peptide transport","nucleotide binding /// DNA binding /// transporter activity /// transporter activity /// protein binding /// ATP binding /// peptide transporter activity /// oligopeptide transporter activity /// ATPase activity /// nucleoside-triphosphatase activity /// ATPase activity, coupled to transmembrane movement of substances /// ATPase activity, coupled to transmembrane movement of substances /// protein heterodimerization activity","membrane fraction /// cytoplasm /// cytoplasm /// endoplasmic reticulum /// nascent polypeptide-associated complex /// integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane","dna repair,transcription:transport,ion channel:immune response",7.2125,1,0.0009,-3,0.8489,0.0157]
[29,18,"201952_AT","ALCAM","activated leukocyte cell adhesion molecule","---","---","cell adhesion /// cell adhesion /// signal transduction /// axon guidance /// motor axon guidance","receptor binding /// protein binding","membrane fraction /// integral to plasma membrane /// external side of plasma membrane /// membrane /// integral to membrane /// axon /// cell soma","cell adhesion:signal transduction,signaling pathway",8.7818,1,0,-2,0.8716,0.0106]
[29,19,"211814_S_AT","CCNE2","cyclin E2","Cell_cycle_KEGG /// Cell_cycle_KEGG /// Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// cell cycle checkpoint /// regulation of cyclin-dependent protein kinase activity /// DNA replication initiation /// cell cycle /// cell division","protein binding /// cyclin-dependent protein kinase regulator activity","nucleus","cell cycle,proliferation:dna replication",2.2559,1,0.8428,0,0.6715,0.0986]
[29,20,"214760_AT","ZNF337","zinc finger protein 337","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription",1.7146,1,0.0002,-3,0.8838,0.0083]
[29,21,"218751_S_AT","FBXW7","F-box and WD repeat domain containing 7","---","---","ubiquitin cycle /// protein ubiquitination","protein binding /// protein binding","---",null,5.0622,1,0,-1,0.8541,0.0144]
[29,22,"77508_R_AT","RABEP2","rabaptin, RAB GTPase binding effector protein 2","---","---","transport /// endocytosis /// protein transport","GTPase activator activity /// growth factor activity","cytoplasm /// endosome","transport,ion channel",7.4209,1,0,0,0.3707,0.4131]
[29,23,"218168_S_AT","CABC1","chaperone, ABC1 activity of bc1 complex homolog (S. pombe)","---","---","protein folding","nucleotide binding /// ATP binding /// kinase activity /// transferase activity","mitochondrion",null,4.5767,1,0,0,0.8632,0.0123]
[29,24,"204947_AT","E2F1","E2F transcription factor 1","Cell_cycle_KEGG /// Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// G1 phase of mitotic cell cycle /// negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent /// Mo-molybdopterin cofactor biosynthetic process /// apoptosis /// apoptosis /// cell cycle /// metabolic process /// cell proliferation /// forebrain development /// positive regulation of transcription from RNA polymerase II promoter","DNA binding /// DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// transcription factor activity /// transcription corepressor activity /// catalytic activity /// iron ion binding /// protein binding /// transcription activator activity /// metal ion binding /// iron-sulfur cluster binding /// 4 iron, 4 sulfur cluster binding","nucleus /// transcription factor complex /// cytoplasm /// molybdopterin synthase complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:cell cycle,proliferation",4.7037,1,0,0,0.8586,0.0134]
[29,25,"211519_S_AT","KIF2C","kinesin family member 2C","---","---","microtubule-based movement /// mitosis /// cell proliferation /// establishment and/or maintenance of microtubule cytoskeleton polarity","nucleotide binding /// motor activity /// microtubule motor activity /// microtubule motor activity /// protein binding /// ATP binding /// centromeric DNA binding","chromosome, pericentric region /// cytoplasm /// kinesin complex /// microtubule /// microtubule associated complex /// microtubule cytoskeleton","cell cycle,proliferation:nuclear matrix,cytoskeleton",13.6947,1,0,-1,-0.4809,0.2746]
[29,26,"203580_S_AT","SLC7A6","solute carrier family 7 (cationic amino acid transporter, y+ system), member 6","---","---","protein complex assembly /// amino acid metabolic process /// transport /// transport /// amino acid transport /// histone methylation /// peptidyl-arginine methylation /// regulation of protein binding","methyltransferase activity /// histone-arginine N-methyltransferase activity /// S-adenosylmethionine-dependent methyltransferase activity /// amino acid transmembrane transporter activity /// amino acid transmembrane transporter activity /// [myelin basic protein]-arginine N-methyltransferase activity /// transferase activity /// protein-arginine omega-N monomethyltransferase activity /// protein-arginine omega-N symmetric methyltransferase activity /// histone binding","nucleus /// cytoplasm /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",2.658,1,0,0,0.6904,0.086]
[29,27,"212020_S_AT","MKI67","antigen identified by monoclonal antibody Ki-67","---","---","regulation of progression through cell cycle /// cell cycle /// cell proliferation","nucleotide binding /// protein binding /// ATP binding","nucleolus","cell cycle,proliferation",20.6116,1,0,-1,-0.5172,0.2345]
[29,28,"208070_S_AT","REV3L","REV3-like, catalytic subunit of DNA polymerase zeta (yeast)","---","---","nucleobase, nucleoside, nucleotide and nucleic acid metabolic process /// DNA replication /// DNA-dependent DNA replication /// DNA repair /// response to DNA damage stimulus","nucleotide binding /// nucleic acid binding /// DNA binding /// DNA-directed DNA polymerase activity /// zeta DNA polymerase activity /// zinc ion binding /// transferase activity /// nucleotidyltransferase activity /// metal ion binding","nucleus /// zeta DNA polymerase complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:dna replication",5.2862,1,0,0,0.5224,0.229]
[29,29,"213523_AT","CCNE1","cyclin E1","Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// G1/S transition of mitotic cell cycle /// cell cycle /// androgen receptor signaling pathway /// positive regulation of transcription, DNA-dependent /// cell division","transcription coactivator activity /// protein binding /// androgen receptor binding","nucleus /// nucleus /// nucleus","dna repair,transcription:cell cycle,proliferation:signal transduction,signaling pathway",1.9631,1,1.9089,-3,0.56,0.1911]
[29,30,"205254_X_AT","TCF7","transcription factor 7 (T-cell specific, HMG-box)","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// immune response /// Wnt receptor signaling pathway","DNA binding /// RNA polymerase II transcription factor activity /// protein binding","---","dna repair,transcription:immune response:signal transduction,signaling pathway",13.8075,1,0,0,-0.6376,0.1234]
[29,31,"212873_AT","HMHA1","histocompatibility (minor) HA-1","---","---","signal transduction /// intracellular signaling cascade","zinc ion binding /// metal ion binding","intracellular","signal transduction,signaling pathway",10.2794,-1,0,0,-0.8439,0.017]
[29,32,"219347_AT","NUDT15","nudix (nucleoside diphosphate linked moiety X)-type motif 15","---","---","---","magnesium ion binding /// hydrolase activity /// manganese ion binding /// metal ion binding","---","unknown",6.3093,1,0,-3,0.4793,0.2765]
[29,33,"200920_S_AT","BTG1","B-cell translocation gene 1, anti-proliferative","Circadian_Exercise /// Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/physiological_process-GenMAPP/Mm_Circadian_Exercise/Mm_Circadian_Exercise.htm","negative regulation of cell proliferation /// cell migration /// negative regulation of cell growth /// regulation of apoptosis /// regulation of transcription /// positive regulation of endothelial cell differentiation /// positive regulation of myoblast differentiation /// positive regulation of angiogenesis","transcription cofactor activity /// protein binding /// enzyme binding /// kinase binding","nucleus /// nucleus /// cytoplasm","dna repair,transcription:cell growth,differentiation:apoptosis:cell cycle,proliferation",17.3396,-1,0,-3,0.2245,0.6285]
[29,34,"218288_S_AT","CCDC90B","coiled-coil domain containing 90B","---","---","---","---","mitochondrion /// mitochondrion /// membrane /// integral to membrane","unknown",2.8346,1,1.9231,-1,0.4675,0.2902]
[29,35,"35974_AT","LRMP","lymphoid-restricted membrane protein","---","---","vesicle targeting /// vesicle fusion /// hemocyte development","---","cytoplasm /// endoplasmic reticulum /// endoplasmic reticulum membrane /// integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane",null,8.363,1,0.0004,-1,0.5414,0.2095]
[29,36,"212560_AT","C11orf32","chromosome 11 open reading frame 32","---","---","---","---","---","unknown",4.6513,1,0,-3,-0.0013,0.9978]
[29,37,"218501_AT","ARHGEF3","Rho guanine nucleotide exchange factor (GEF) 3","---","---","Rho protein signal transduction /// regulation of Rho protein signal transduction","guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity","intracellular /// intracellular /// cytoplasm","signal transduction,signaling pathway",5.4288,1,0.0003,-3,0.2315,0.6174]
[29,38,"215411_S_AT","TRAF3IP2","TRAF3 interacting protein 2","---","---","intracellular signaling cascade /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity","---",null,3.7423,1,0.7444,-3,0.4531,0.3073]
[29,39,"204573_AT","CROT","carnitine O-octanoyltransferase","---","---","generation of precursor metabolites and energy /// lipid metabolic process /// fatty acid metabolic process /// fatty acid metabolic process /// transport /// fatty acid transport","acyltransferase activity /// carnitine O-octanoyltransferase activity /// carnitine O-octanoyltransferase activity /// transferase activity","peroxisome /// peroxisome","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",1.1724,1,1.6717,-3,0.4114,0.3592]
[]
[null,null,30]
[30,1,"221943_X_AT","RPL38","Ribosomal protein L38","Ribosomal_Proteins /// Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/molecular_function_GenMAPP/Rn_Ribosomal_Proteins/Rn_Ribosomal_Proteins.htm","translation /// translation","RNA binding /// structural constituent of ribosome /// structural constituent of ribosome /// protein binding","intracellular /// ribosome /// cytosolic large ribosomal subunit (sensu Eukaryota) /// ribonucleoprotein complex",null,0.2858,1,1.4401,-2,0.5116,0.2405]
[30,2,"205255_X_AT","TCF7","transcription factor 7 (T-cell specific, HMG-box)","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription from RNA polymerase II promoter /// immune response /// Wnt receptor signaling pathway","DNA binding /// RNA polymerase II transcription factor activity /// protein binding","---","dna repair,transcription:immune response:signal transduction,signaling pathway",1.3697,1,0,-2,-0.4909,0.2633]
[30,3,"202503_S_AT","KIAA0101","KIAA0101","---","---","---","---","mitochondrion","unknown",0.2318,1,1.1909,-4,0.0023,0.9962]
[]
[null,null,31]
[31,1,"201810_S_AT","SH3BP5","SH3-domain binding protein 5 (BTK-associated)","---","---","signal transduction /// intracellular signaling cascade","protein kinase inhibitor activity /// SH3/SH2 adaptor activity /// protein binding","cytoplasm /// mitochondrion","signal transduction,signaling pathway",117.4275,1,1.8688,4,-0.9239,0.0029]
[31,2,"218303_X_AT","KRCC1","lysine-rich coiled-coil 1","---","---","---","---","---","unknown",2.8216,-1,0,-2,-0.2211,0.6338]
[31,3,"209406_AT","BAG2","BCL2-associated athanogene 2","---","---","protein folding /// protein folding /// apoptosis /// protein metabolic process","protein binding /// protein binding /// chaperone regulator activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis",12.3966,1,1.2601,0,-0.6848,0.0896]
[31,4,"204079_AT","TPST2","tyrosylprotein sulfotransferase 2","---","---","peptidyl-tyrosine sulfation","protein-tyrosine sulfotransferase activity /// protein-tyrosine sulfotransferase activity /// transferase activity","membrane fraction /// endoplasmic reticulum /// Golgi apparatus /// membrane /// integral to membrane",null,6.4368,1,0,-6,-0.9514,0.001]
[31,5,"204318_S_AT","GTSE1","G-2 and S-phase expressed 1","---","---","G2 phase of mitotic cell cycle /// DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest /// microtubule-based process","---","cytoplasm /// microtubule /// cytoplasmic microtubule","cell cycle,proliferation:signal transduction,signaling pathway",12.1796,1,0,2,-0.8793,0.0091]
[31,6,"203394_S_AT","HES1","hairy and enhancer of split 1, (Drosophila)","---","---","negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent /// cell adhesion /// nervous system development /// positive regulation of cell proliferation /// lung development /// auditory receptor cell differentiation /// auditory receptor cell fate determination /// cell fate commitment /// regulation of transcription /// negative regulation of cell differentiation /// negative regulation of auditory receptor cell differentiation /// negative regulation of neuron differentiation /// cell maturation","DNA binding /// DNA binding /// transcription repressor activity /// transcription regulator activity","nucleus /// cytoplasm","dna repair,transcription:cell growth,differentiation:cell adhesion:cell cycle,proliferation",7.7173,-1,0,2,-0.5805,0.1718]
[31,7,"205882_X_AT","ADD3","adducin 3 (gamma)","---","---","---","structural constituent of cytoskeleton /// calmodulin binding /// metal ion binding","cytoplasm /// cytoskeleton /// membrane /// membrane","unknown",6.7879,1,0,-6,-0.9409,0.0016]
[31,8,"217147_S_AT","TRAT1","T cell receptor associated transmembrane adaptor 1","---","---","negative regulation of receptor recycling /// immune response /// cellular defense response /// signal transduction /// positive regulation of calcium-mediated signaling /// positive regulation of T cell receptor signaling pathway /// negative regulation of transport","transmembrane receptor protein tyrosine kinase adaptor protein activity","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane /// T cell receptor complex","transport,ion channel:immune response:signal transduction,signaling pathway",11.3278,1,0,-4,-0.8834,0.0084]
[31,9,"207992_S_AT","AMPD3","adenosine monophosphate deaminase (isoform E)","---","---","AMP catabolic process /// nucleotide metabolic process /// purine ribonucleoside monophosphate biosynthetic process","AMP deaminase activity /// AMP deaminase activity /// hydrolase activity /// deaminase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",8.1468,1,0,4,-0.7335,0.0606]
[31,10,"219443_AT","TASP1","taspase, threonine aspartase, 1","---","---","glycoprotein catabolic process","asparaginase activity /// threonine endopeptidase activity /// peptidase activity /// hydrolase activity","---",null,7.3442,1,0,-2,-0.8264,0.0219]
[31,11,"218927_S_AT","CHST12","carbohydrate (chondroitin 4) sulfotransferase 12","---","---","carbohydrate metabolic process /// chondroitin sulfate biosynthetic process /// chondroitin sulfate biosynthetic process /// dermatan sulfate biosynthetic process /// dermatan sulfate biosynthetic process","protein binding /// transferase activity /// chondroitin 4-sulfotransferase activity /// chondroitin 4-sulfotransferase activity /// chondroitin 4-sulfotransferase activity /// 3'-phosphoadenosine 5'-phosphosulfate binding","membrane /// integral to membrane /// integral to Golgi membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",7.8851,1,0,2,-0.9844,0.0001]
[31,12,"209112_AT","CDKN1B","cyclin-dependent kinase inhibitor 1B (p27, Kip1)","G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome /// Ovarian_Infertility_Genes /// Ovarian_Infertility_Genes /// Ovarian_Infertility_Genes","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// cell cycle /// cell cycle arrest /// cell cycle arrest /// sensory perception of sound /// positive regulation of cell proliferation /// negative regulation of cell proliferation /// negative regulation of cell proliferation /// positive regulation of microtubule polymerization /// negative regulation of cyclin-dependent protein kinase activity /// inner ear development /// negative regulation of epithelial cell proliferation /// negative regulation of cell motility","protein kinase inhibitor activity /// cyclin-dependent protein kinase inhibitor activity /// cyclin-dependent protein kinase inhibitor activity /// transforming growth factor beta receptor, cytoplasmic mediator activity /// protein binding /// kinase activity","nucleus /// nucleus /// cytoplasm /// cytoplasm /// cytosol","cell cycle,proliferation",14.8664,1,0,4,-0.8758,0.0098]
[31,13,"213248_AT","LOC730101","similar to heterogeneous nuclear ribonucleoprotein A/B","---","---","---","---","---","unknown",4.6641,1,0,-4,-0.6649,0.1032]
[31,14,"204040_AT","RNF144A","ring finger protein 144A","---","---","ubiquitin cycle","protein binding /// zinc ion binding /// metal ion binding","Golgi apparatus",null,4.1534,1,0,6,-0.6681,0.101]
[31,15,"221436_S_AT","CDCA3","cell division cycle associated 3","---","---","ubiquitin cycle /// cell cycle /// mitosis /// cell division","---","cytoplasm","cell cycle,proliferation",5.1026,1,0,-4,-0.7666,0.0444]
[31,16,"220668_S_AT","DNMT3B","DNA (cytosine-5-)-methyltransferase 3 beta","---","---","DNA methylation /// DNA methylation /// DNA methylation","DNA binding /// DNA (cytosine-5-)-methyltransferase activity /// DNA (cytosine-5-)-methyltransferase activity /// protein binding /// methyltransferase activity /// zinc ion binding /// site-specific DNA-methyltransferase (cytosine-specific) activity /// site-specific DNA-methyltransferase (cytosine-specific) activity /// DNA-methyltransferase activity /// transferase activity /// metal ion binding","nucleus",null,7.0605,-1,0,2,-0.9221,0.0031]
[31,17,"204159_AT","CDKN2C","cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)","G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","cell cycle /// cell cycle arrest /// negative regulation of cell proliferation","cyclin-dependent protein kinase inhibitor activity /// protein binding /// kinase activity","nucleus /// cytoplasm","cell cycle,proliferation",7.6246,1,1.8876,-6,-0.815,0.0255]
[31,18,"204641_AT","NEK2","NIMA (never in mitosis gene a)-related kinase 2","---","---","regulation of progression through cell cycle /// protein amino acid phosphorylation /// cell cycle /// mitosis /// mitosis /// regulation of mitosis /// meiosis /// cell division","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// metal ion binding","cytoplasm /// centrosome","cell cycle,proliferation",11.1402,1,0,4,-0.9644,0.0004]
[31,19,"212136_AT","ATP2B4","ATPase, Ca++ transporting, plasma membrane 4","---","---","protein folding /// protein folding /// transport /// transport /// ion transport /// cation transport /// calcium ion transport /// response to unfolded protein /// metabolic process /// protein import into mitochondrial matrix /// regulation of apoptosis /// cellular protein metabolic process","nucleotide binding /// magnesium ion binding /// catalytic activity /// calcium-transporting ATPase activity /// calcium-transporting ATPase activity /// calcium ion binding /// protein binding /// protein binding /// calmodulin binding /// ATP binding /// ATP binding /// calcium ion transmembrane transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances /// metal ion binding /// unfolded protein binding /// unfolded protein binding /// chaperone binding","cytoplasm /// mitochondrion /// mitochondrion /// plasma membrane /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:apoptosis",11.9219,1,0,-6,-0.9818,0.0001]
[31,20,"210858_X_AT","ATM","ataxia telangiectasia mutated","Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome /// Ovarian_Infertility_Genes","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Ovarian_Infertility_Genes/Hs_Ovarian_Infertility_Genes.htm","regulation of progression through cell cycle /// DNA repair /// DNA repair /// response to DNA damage stimulus /// cell cycle /// mitotic cell cycle spindle assembly checkpoint /// meiotic recombination /// signal transduction /// response to ionizing radiation /// negative regulation of progression through cell cycle","DNA binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein binding /// kinase activity /// 1-phosphatidylinositol-3-kinase activity /// transferase activity /// phosphotransferase activity, alcohol group as acceptor /// protein N-terminus binding","cytoplasmic vesicle","dna repair,transcription:cell cycle,proliferation:signal transduction,signaling pathway",8.4701,1,0,-6,-0.9432,0.0014]
[31,21,"219563_AT","C14orf139","chromosome 14 open reading frame 139","---","---","---","---","---","unknown",4.5144,1,0,2,-0.7917,0.0339]
[31,22,"213888_S_AT","TRAF3IP3","TRAF3 interacting protein 3","---","---","---","---","membrane /// integral to membrane","unknown",16.105,1,1.8688,-4,-0.866,0.0117]
[31,23,"210821_X_AT","CENPA","centromere protein A","---","---","nucleosome assembly /// chromosome organization and biogenesis (sensu Eukaryota) /// chromosome organization and biogenesis (sensu Eukaryota)","DNA binding /// chromatin binding","chromosome, pericentric region /// chromosome, pericentric region /// chromosome, pericentric region /// nucleosome /// nucleus /// nucleus /// chromosome /// membrane /// integral to membrane",null,11.0712,1,0,2,-0.9383,0.0018]
[31,24,"210221_AT","CHRNA3","cholinergic receptor, nicotinic, alpha 3","---","---","transport /// transport /// ion transport /// signal transduction","receptor activity /// nicotinic acetylcholine-activated cation-selective channel activity /// nicotinic acetylcholine-activated cation-selective channel activity /// transporter activity /// ion channel activity /// extracellular ligand-gated ion channel activity /// acetylcholine receptor activity /// neurotransmitter receptor activity","nicotinic acetylcholine-gated receptor-channel complex /// membrane /// integral to membrane /// cell junction /// synapse /// postsynaptic membrane","transport,ion channel:signal transduction,signaling pathway",4.0572,1,1.6805,-6,-0.4362,0.3279]
[31,25,"204822_AT","TTK","TTK protein kinase","---","---","regulation of progression through cell cycle /// protein amino acid phosphorylation /// spindle organization and biogenesis /// mitotic spindle organization and biogenesis /// mitotic cell cycle spindle assembly checkpoint /// positive regulation of cell proliferation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein-tyrosine kinase activity /// protein-tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity","spindle","cell cycle,proliferation",12.8016,-1,0,0,-0.8654,0.0119]
[31,26,"211559_S_AT","CCNG2","cyclin G2","G1_to_S_cell_cycle_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// cell cycle checkpoint /// cell cycle /// mitosis /// cell division","---","cytoplasm","cell cycle,proliferation",6.9865,-1,0,0,-0.599,0.1552]
[31,27,"203386_AT","TBC1D4","TBC1 domain family, member 4","---","---","regulation of Rab GTPase activity","GTPase activator activity /// Rab GTPase activator activity","intracellular",null,26.0191,-1,0,-4,-0.7763,0.0401]
[31,28,"205167_S_AT","CDC25C","cell division cycle 25 homolog C (S. pombe)","Cell_cycle_KEGG /// Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","regulation of cyclin-dependent protein kinase activity /// M phase of mitotic cell cycle /// M phase of mitotic cell cycle /// protein amino acid dephosphorylation /// cell cycle /// mitosis /// regulation of mitosis /// traversing start control point of mitotic cell cycle /// cell proliferation /// cell division","phosphoprotein phosphatase activity /// protein tyrosine phosphatase activity /// protein tyrosine phosphatase activity /// protein binding /// hydrolase activity","intracellular","cell cycle,proliferation",9.481,1,0,-6,-0.7719,0.042]
[31,29,"218807_AT","VAV3","vav 3 guanine nucleotide exchange factor","Integrin-mediated_cell_adhesion_KEGG /// Integrin-mediated_cell_adhesion_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm","intracellular signaling cascade /// small GTPase mediated signal transduction /// regulation of Rho protein signal transduction","SH3/SH2 adaptor activity /// guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity /// GTPase activator activity /// zinc ion binding /// diacylglycerol binding /// metal ion binding","intracellular","signal transduction,signaling pathway",6.5126,-1,0.2976,-6,-0.7619,0.0465]
[31,30,"219544_AT","C13orf34","chromosome 13 open reading frame 34","---","---","cell cycle /// mitosis /// cell division","---","---","cell cycle,proliferation",9.8345,-1,0,-6,-0.8075,0.0281]
[31,31,"204162_AT","NDC80","NDC80 homolog, kinetochore complex component (S. cerevisiae)","---","---","mitotic sister chromatid segregation /// cell cycle /// cell cycle /// spindle organization and biogenesis /// mitosis /// mitosis /// phosphoinositide-mediated signaling /// cell division","protein binding","chromosome, pericentric region /// chromosome, pericentric region /// nucleus","cell cycle,proliferation",14.5422,1,0,-2,-0.8542,0.0144]
[31,32,"206364_AT","KIF14","kinesin family member 14","---","---","microtubule-based movement","nucleotide binding /// motor activity /// microtubule motor activity /// ATP binding","microtubule /// microtubule associated complex",null,17.7935,-1,0,-6,-0.9545,0.0008]
[31,33,"218755_AT","KIF20A","kinesin family member 20A","---","---","transport /// microtubule-based movement /// protein transport /// vesicle-mediated transport","nucleotide binding /// motor activity /// microtubule motor activity /// transporter activity /// ATP binding","Golgi apparatus /// microtubule /// microtubule associated complex","transport,ion channel",16.3779,-1,0,-6,-0.8464,0.0163]
[31,34,"205698_S_AT","MAP2K6","mitogen-activated protein kinase kinase 6","Integrin-mediated_cell_adhesion_KEGG /// MAPK_Cascade","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Integrin-mediated_cell_adhesion_KEGG/Hs_Integrin-mediated_cell_adhesion_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_MAPK_Cascade/Hs_MAPK_Cascade.htm","MAPKKK cascade /// activation of MAPK activity /// protein amino acid phosphorylation /// DNA damage induced protein phosphorylation /// cell cycle arrest /// signal transduction","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// MAP kinase kinase activity /// protein-tyrosine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","---","cell cycle,proliferation:signal transduction,signaling pathway",12.8076,1,0,-4,-0.8794,0.0091]
[31,35,"201896_S_AT","PSRC1","proline/serine-rich coiled-coil 1","Electron_Transport_Chain","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Electron_Transport_Chain/Hs_Electron_Transport_Chain.htm","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// electron transport /// mitochondrial electron transport, NADH to ubiquinone /// cell cycle /// cell proliferation /// cell division","NADH dehydrogenase activity /// protein binding /// NADH dehydrogenase (ubiquinone) activity /// NADH dehydrogenase (ubiquinone) activity /// oxidoreductase activity /// cyclin-dependent protein kinase regulator activity","cytoplasm /// mitochondrion /// mitochondrial respiratory chain complex I /// endoplasmic reticulum /// membrane","transport,ion channel:cell cycle,proliferation",18.8903,-1,0,4,-0.9042,0.0052]
[]
[null,null,32]
[32,1,"209026_X_AT","TUBB","tubulin, beta","Glycolysis_and_Gluconeogenesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm","fructose metabolic process /// glycolysis /// transcription /// regulation of transcription, DNA-dependent /// rRNA processing /// regulation of translation /// proteolysis /// cell motility /// microtubule-based process /// microtubule-based movement /// cell cycle arrest /// metabolic process /// cell proliferation /// natural killer cell mediated cytotoxicity /// negative regulation of transcription, DNA-dependent /// protein polymerization","nucleotide binding /// DNA binding /// transcription factor activity /// RNA binding /// catalytic activity /// GTPase activity /// methionyl aminopeptidase activity /// fructose-bisphosphate aldolase activity /// fructose-bisphosphate aldolase activity /// structural molecule activity /// protein binding /// protein binding /// GTP binding /// metalloexopeptidase activity /// hydrolase activity /// lyase activity /// MHC class I protein binding /// cobalt ion binding","nucleus /// nucleus /// cytoplasm /// cytoskeleton /// microtubule /// ribonucleoprotein complex /// protein complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:proteolysis",0.1603,1,1.2559,2,0.5651,0.1862]
[32,2,"211714_X_AT","TUBB","tubulin, beta","Glycolysis_and_Gluconeogenesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm","fructose metabolic process /// glycolysis /// transcription /// regulation of transcription, DNA-dependent /// rRNA processing /// regulation of translation /// proteolysis /// cell motility /// microtubule-based process /// microtubule-based movement /// cell cycle arrest /// metabolic process /// cell proliferation /// natural killer cell mediated cytotoxicity /// negative regulation of transcription, DNA-dependent /// protein polymerization","nucleotide binding /// DNA binding /// transcription factor activity /// RNA binding /// catalytic activity /// GTPase activity /// methionyl aminopeptidase activity /// fructose-bisphosphate aldolase activity /// fructose-bisphosphate aldolase activity /// structural molecule activity /// protein binding /// protein binding /// GTP binding /// metalloexopeptidase activity /// hydrolase activity /// lyase activity /// MHC class I protein binding /// cobalt ion binding","nucleus /// nucleus /// cytoplasm /// cytoskeleton /// microtubule /// ribonucleoprotein complex /// protein complex","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:proteolysis",0.1495,1,1.403,0,0.5364,0.2145]
[32,3,"201202_AT","PCNA","proliferating cell nuclear antigen","Cell_cycle_KEGG /// DNA_replication_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// DNA replication /// DNA replication /// regulation of DNA replication /// DNA repair /// base-excision repair, gap-filling /// intracellular protein transport /// cell proliferation /// phosphoinositide-mediated signaling","DNA binding /// protein binding /// DNA polymerase processivity factor activity /// MutLalpha complex binding","cyclin-dependent protein kinase holoenzyme complex /// nucleus /// nuclear lamina /// replication fork /// DNA replication factor C complex /// PCNA complex","dna repair,transcription:transport,ion channel:cell cycle,proliferation:dna replication",0.1148,1,1.0696,2,0.6102,0.1456]
[32,4,"213414_S_AT","RPS19","ribosomal protein S19","Ribosomal_Proteins /// Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm","translation /// translation /// response to extracellular stimulus /// gas transport /// erythrocyte differentiation /// anatomical structure development /// positive regulation of cell motility","RNA binding /// structural constituent of ribosome /// structural constituent of ribosome /// structural constituent of ribosome /// protein binding","intracellular /// nucleolus /// ribosome /// cytosolic small ribosomal subunit (sensu Eukaryota) /// cytosolic small ribosomal subunit (sensu Eukaryota) /// ribonucleoprotein complex","cell growth,differentiation:transport,ion channel",0.2276,1,0,2,0.208,0.6544]
[32,5,"216705_S_AT","ADA","adenosine deaminase","---","---","purine nucleotide metabolic process /// immune response /// nucleotide metabolic process /// purine ribonucleoside monophosphate biosynthetic process","adenosine deaminase activity /// adenosine deaminase activity /// hydrolase activity /// deaminase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:immune response",0.2235,1,1.6829,4,-0.2144,0.6444]
[32,6,"204639_AT","ADA","adenosine deaminase","---","---","purine nucleotide metabolic process /// immune response /// nucleotide metabolic process /// purine ribonucleoside monophosphate biosynthetic process","adenosine deaminase activity /// adenosine deaminase activity /// hydrolase activity /// deaminase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:immune response",0.6029,1,0,2,-0.2474,0.5928]
[32,7,"202649_X_AT","RPS19","ribosomal protein S19","Ribosomal_Proteins /// Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm","translation /// translation /// response to extracellular stimulus /// gas transport /// erythrocyte differentiation /// anatomical structure development /// positive regulation of cell motility","RNA binding /// structural constituent of ribosome /// structural constituent of ribosome /// structural constituent of ribosome /// protein binding","intracellular /// nucleolus /// ribosome /// cytosolic small ribosomal subunit (sensu Eukaryota) /// cytosolic small ribosomal subunit (sensu Eukaryota) /// ribonucleoprotein complex","cell growth,differentiation:transport,ion channel",0.1396,1,1.4202,2,0.1243,0.7906]
[]
[null,null,33]
[33,1,"214096_S_AT","SHMT2","serine hydroxymethyltransferase 2 (mitochondrial)","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational elongation /// translational elongation /// glycine metabolic process /// L-serine metabolic process /// one-carbon compound metabolic process","translation elongation factor activity /// translation elongation factor activity /// catalytic activity /// glycine hydroxymethyltransferase activity /// protein binding /// methyltransferase activity /// transferase activity /// pyridoxal phosphate binding","intracellular /// mitochondrion /// mitochondrion /// eukaryotic translation elongation factor 1 complex","biosynthesis,metabolism,metabolic process,biosynthetic process",1.1241,1,0,1,0.6512,0.1131]
[33,2,"221434_S_AT","C14orf156","chromosome 14 open reading frame 156","---","---","transcription /// regulation of transcription, DNA-dependent","nucleotide binding /// nucleic acid binding /// RNA binding","mitochondrion","dna repair,transcription",1.2672,-1,0,1,0.3701,0.4138]
[33,3,"212414_S_AT","N-PAC /// SEPT6","septin 6 /// cytokine-like nuclear factor n-pac","---","---","cytokinesis /// pentose-phosphate shunt /// cell cycle /// cell division","nucleotide binding /// phosphogluconate dehydrogenase (decarboxylating) activity /// protein binding /// protein binding /// GTP binding /// GTP binding /// oxidoreductase activity /// coenzyme binding","---","cell cycle,proliferation",0.5563,-1,0,1,-0.3801,0.4003]
[33,4,"220147_S_AT","FAM60A","family with sequence similarity 60, member A","---","---","---","---","---","unknown",2.101,1,0,1,0.5567,0.1943]
[33,5,"201251_AT","PKM2","pyruvate kinase, muscle","Glycolysis_and_Gluconeogenesis /// Glycolysis_and_Gluconeogenesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm","glycolysis /// glycolysis","magnesium ion binding /// catalytic activity /// pyruvate kinase activity /// pyruvate kinase activity /// protein binding /// kinase activity /// transferase activity /// potassium ion binding /// metal ion binding","cytoplasm /// mitochondrion /// cytosol",null,1.2523,-1,0,1,0.2504,0.5881]
[33,6,"213097_S_AT","ZRF1","zuotin related factor 1","---","---","protein folding /// protein folding /// regulation of transcription","DNA binding /// heat shock protein binding /// unfolded protein binding","nucleus /// nucleus","dna repair,transcription",1.4215,-1,0,1,0.2534,0.5835]
[33,7,"216237_S_AT","MCM5","minichromosome maintenance complex component 5","Cell_cycle_KEGG /// DNA_replication_Reactome /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// DNA replication /// DNA replication /// DNA replication initiation /// transcription /// regulation of transcription, DNA-dependent","nucleotide binding /// DNA binding /// protein binding /// ATP binding /// DNA-dependent ATPase activity","nucleus /// nucleus","dna repair,transcription:cell cycle,proliferation:dna replication",1.5526,1,0,1,0.7149,0.071]
[33,8,"205349_AT","GNA15","guanine nucleotide binding protein (G protein), alpha 15 (Gq class)","G_Protein_Signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G_Protein_Signaling/Hs_G_Protein_Signaling.htm","protein amino acid ADP-ribosylation /// signal transduction /// G-protein coupled receptor protein signaling pathway /// G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) /// phospholipase C activation /// elevation of cytosolic calcium ion concentration /// muscarinic acetylcholine receptor, phospholipase C activating pathway","nucleotide binding /// GTPase activity /// signal transducer activity /// signal transducer activity /// GTP binding /// GTP binding /// guanyl nucleotide binding","heterotrimeric G-protein complex /// plasma membrane","signal transduction,signaling pathway",0.9614,1,0,1,0.8586,0.0134]
[33,9,"201761_AT","MTHFD2","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase","Nucleotide_Metabolism /// Nucleotide_Metabolism","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Nucleotide_Metabolism/Hs_Nucleotide_Metabolism.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Nucleotide_Metabolism/Hs_Nucleotide_Metabolism.htm","one-carbon compound metabolic process /// folic acid and derivative biosynthetic process /// tetrahydrofolate metabolic process","magnesium ion binding /// magnesium ion binding /// catalytic activity /// methenyltetrahydrofolate cyclohydrolase activity /// methenyltetrahydrofolate cyclohydrolase activity /// methylenetetrahydrofolate dehydrogenase (NAD+) activity /// methylenetetrahydrofolate dehydrogenase (NAD+) activity /// methylenetetrahydrofolate dehydrogenase (NADP+) activity /// oxidoreductase activity /// hydrolase activity /// phosphate binding","mitochondrion /// mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",0.1848,-1,0.3895,1,-0.2435,0.5988]
[33,10,"211911_X_AT","HLA-B","major histocompatibility complex, class I, B","Proteasome_Degradation /// Proteasome_Degradation /// Proteasome_Degradation","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm","antigen processing and presentation of peptide antigen via MHC class I /// defense response /// immune response /// immune response /// antigen processing and presentation","protein binding /// MHC class I receptor activity","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane /// MHC class I protein complex","immune response",0.6855,1,0,0,0.8486,0.0158]
[33,11,"206445_S_AT","PRMT1","protein arginine methyltransferase 1","mRNA_processing_Reactome /// mRNA_processing_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_mRNA_processing_Reactome/Hs_mRNA_processing_Reactome.htm","in utero embryonic development /// protein amino acid methylation /// defense response /// cell surface receptor linked signal transduction","protein binding /// methyltransferase activity /// methyltransferase activity /// N-methyltransferase activity /// protein methyltransferase activity /// transferase activity","nucleus /// cytoplasm","signal transduction,signaling pathway",1.7375,-1,0,0,0.4594,0.2997]
[33,12,"217294_S_AT","ENO1","enolase 1, (alpha)","Apoptosis /// Apoptosis_GenMAPP /// Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome /// Glycolysis_and_Gluconeogenesis /// Glycolysis_and_Gluconeogenesis /// Glycolysis_and_Gluconeogenesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Glycolysis_and_Gluconeogenesis/Hs_Glycolysis_and_Gluconeogenesis.htm","regulation of progression through cell cycle /// negative regulation of transcription from RNA polymerase II promoter /// negative regulation of transcription from RNA polymerase II promoter /// glycolysis /// transcription /// regulation of transcription, DNA-dependent /// protein complex assembly /// ubiquitin cycle /// metabolic process /// negative regulation of cell proliferation /// protein ubiquitination /// negative regulation of cell growth /// regulation of protein catabolic process /// negative regulation of transcription, DNA-dependent","magnesium ion binding /// DNA binding /// transcription factor activity /// transcription corepressor activity /// catalytic activity /// phosphopyruvate hydratase activity /// phosphopyruvate hydratase activity /// ubiquitin-protein ligase activity /// protein binding /// protein binding /// plasminogen activator activity /// zinc ion binding /// zinc ion binding /// transcription repressor activity /// lyase activity /// ligase activity /// negative regulator of basal transcription activity /// enzyme binding /// metal ion binding","phosphopyruvate hydratase complex /// intracellular /// nucleus /// nucleus /// nucleoplasm /// nucleolus /// cytoplasm /// cytoplasm /// membrane","dna repair,transcription:cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",0.9282,-1,1.6385,0,-0.0816,0.8619]
[33,13,"208881_X_AT","IDI1","isopentenyl-diphosphate delta isomerase 1","Cholesterol_Biosynthesis /// Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","steroid biosynthetic process /// cholesterol biosynthetic process /// isoprenoid biosynthetic process /// isoprenoid biosynthetic process /// lipid biosynthetic process /// carotenoid biosynthetic process /// sterol biosynthetic process","magnesium ion binding /// isopentenyl-diphosphate delta-isomerase activity /// isopentenyl-diphosphate delta-isomerase activity /// hydrolase activity /// isomerase activity /// metal ion binding","peroxisome /// peroxisome","biosynthesis,metabolism,metabolic process,biosynthetic process",2.0918,-1,0,0,0.5058,0.2468]
[33,14,"208152_S_AT","DDX21","DEAD (Asp-Glu-Ala-Asp) box polypeptide 21","---","---","---","nucleotide binding /// nucleic acid binding /// RNA binding /// ATP-dependent RNA helicase activity /// helicase activity /// protein binding /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity","nucleus /// nucleolus","unknown",1.5638,-1,0,0,0.383,0.3965]
[33,15,"208693_S_AT","GARS","glycyl-tRNA synthetase","---","---","translation /// tRNA aminoacylation for protein translation /// glycyl-tRNA aminoacylation","nucleotide binding /// aminoacyl-tRNA ligase activity /// glycine-tRNA ligase activity /// glycine-tRNA ligase activity /// ATP binding /// ligase activity","soluble fraction /// cytoplasm /// cytoplasm",null,1.0103,-1,0,0,0.5045,0.2483]
[33,16,"204615_X_AT","IDI1","isopentenyl-diphosphate delta isomerase 1","Cholesterol_Biosynthesis /// Circadian_Exercise","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Circadian_Exercise/Hs_Circadian_Exercise.htm","steroid biosynthetic process /// cholesterol biosynthetic process /// isoprenoid biosynthetic process /// isoprenoid biosynthetic process /// lipid biosynthetic process /// carotenoid biosynthetic process /// sterol biosynthetic process","magnesium ion binding /// isopentenyl-diphosphate delta-isomerase activity /// isopentenyl-diphosphate delta-isomerase activity /// hydrolase activity /// isomerase activity /// metal ion binding","peroxisome /// peroxisome","biosynthesis,metabolism,metabolic process,biosynthetic process",2.2711,1,0,0,0.5574,0.1936]
[33,17,"201627_S_AT","INSIG1","insulin induced gene 1","---","---","lipid metabolic process /// metabolic process /// steroid metabolic process /// cholesterol metabolic process /// cell proliferation","---","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",1.4561,-1,0,0,0.3584,0.4298]
[33,18,"209218_AT","SQLE","squalene epoxidase","Cholesterol_Biosynthesis /// Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","electron transport /// metabolic process /// sterol biosynthetic process","squalene monooxygenase activity /// squalene monooxygenase activity /// oxidoreductase activity","endoplasmic reticulum /// microsome /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",2.4936,1,0,0,0.3476,0.4449]
[33,19,"200608_S_AT","RAD21","RAD21 homolog (S. pombe)","---","---","DNA repair /// double-strand break repair /// DNA recombination /// apoptosis /// response to DNA damage stimulus /// chromosome organization and biogenesis (sensu Eukaryota) /// cell cycle /// chromosome segregation /// mitosis /// meiotic recombination /// cell division","protein binding","nuclear chromosome","dna repair,transcription:apoptosis:cell cycle,proliferation",0.6737,-1,0,0,-0.9242,0.0029]
[]
[null,null,34]
[34,1,"65517_AT","AP1M2","adaptor-related protein complex 1, mu 2 subunit","---","---","protein complex assembly /// protein targeting /// transport /// intracellular protein transport /// vesicle targeting /// protein transport /// vesicle-mediated transport","protein binding /// protein binding /// protein transporter activity","membrane /// clathrin adaptor complex /// cytoplasmic vesicle","transport,ion channel",3.3355,1,0,-1,0.3989,0.3754]
[34,2,"221404_AT","IL1F6","interleukin 1 family, member 6 (epsilon)","---","---","inflammatory response /// immune response /// immune response","cytokine activity /// interleukin-1 receptor binding /// interleukin-1 receptor binding","extracellular region /// extracellular region /// extracellular space","immune response",2.4864,1,0.0003,-3,0.4739,0.2827]
[34,3,"210879_S_AT","RAB11FIP5","RAB11 family interacting protein 5 (class I)","---","---","transport /// protein transport","protein binding /// gamma-tubulin binding","cytoplasm /// mitochondrion /// mitochondrial outer membrane /// endosome /// membrane","transport,ion channel",3.3913,1,0.5961,-3,0.0307,0.948]
[34,4,"218581_AT","ABHD4","abhydrolase domain containing 4","---","---","proteolysis /// aromatic compound metabolic process /// lipid catabolic process","aminopeptidase activity /// hydrolase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process:proteolysis",1.2584,1,0,-2,0.3757,0.4063]
[34,5,"207752_X_AT","PRB1 /// PRB2","proline-rich protein BstNI subfamily 1 /// proline-rich protein BstNI subfamily 2","---","---","G-protein coupled receptor protein signaling pathway","rhodopsin-like receptor activity","extracellular region /// integral to membrane","signal transduction,signaling pathway",4.2713,1,0,0,0.5679,0.1835]
[34,6,"211123_AT","SLC5A5","solute carrier family 5 (sodium iodide symporter), member 5","---","---","transport /// transport /// ion transport /// sodium ion transport","transporter activity /// sodium:iodide symporter activity /// iodide transmembrane transporter activity /// symporter activity /// sodium ion binding","membrane /// integral to membrane /// integral to membrane","transport,ion channel",3.6828,1,0,-1,0.4741,0.2824]
[34,7,"220714_AT","PRDM14","PR domain containing 14","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription",2.2866,1,0.1893,-1,0.2132,0.6462]
[34,8,"213343_S_AT","GDPD5","glycerophosphodiester phosphodiesterase domain containing 5","---","---","glycerol metabolic process","glycerophosphodiester phosphodiesterase activity /// hydrolase activity","cytoplasm /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",2.5528,1,0.0007,0,0.3498,0.4418]
[34,9,"220379_AT","FSCN3","fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)","---","---","---","actin binding /// protein binding, bridging /// actin filament binding","cytoplasm /// cytoskeleton","unknown",3.3855,1,0,-2,0.2638,0.5675]
[34,10,"209736_AT","SOX13","SRY (sex determining region Y)-box 13","---","---","regulation of transcription, DNA-dependent /// anatomical structure morphogenesis","DNA binding /// transcription factor activity","---","dna repair,transcription",2.6878,1,0,0,0.4174,0.3515]
[34,11,"210313_AT","LILRA4","leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4","---","---","immune response","receptor activity","membrane /// integral to membrane","immune response",1.9971,1,0,0,0.3814,0.3986]
[34,12,"206681_X_AT","GP2","glycoprotein 2 (zymogen granule membrane)","---","---","---","GPI anchor binding","membrane fraction /// membrane","unknown",2.9659,1,0,-1,0.2718,0.5554]
[34,13,"202053_S_AT","ALDH3A2","aldehyde dehydrogenase 3 family, member A2","---","---","aldehyde metabolic process /// lipid metabolic process /// central nervous system development /// peripheral nervous system development /// metabolic process /// epidermis development","3-chloroallyl aldehyde dehydrogenase activity /// aldehyde dehydrogenase (NAD) activity /// aldehyde dehydrogenase [NAD(P)+] activity /// oxidoreductase activity","endoplasmic reticulum /// microsome /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",3.6648,1,0,-3,0.3798,0.4007]
[34,14,"206798_X_AT","DLEC1","deleted in lung and esophageal cancer 1","---","---","cell cycle /// negative regulation of cell proliferation /// negative regulation of progression through cell cycle","---","cytoplasm /// cytoplasm","cell cycle,proliferation",2.482,1,0.724,-3,0.3512,0.4398]
[34,15,"221407_AT","GJA9","gap junction protein, alpha 9, 36kDa","---","---","cell communication /// cell communication /// cell-cell signaling /// synaptic transmission /// visual perception","gap junction channel activity","gap junction /// gap junction /// connexon complex /// membrane /// integral to membrane /// cell junction",null,3.2126,1,0.0007,0,0.4763,0.2799]
[34,16,"209114_AT","TSPAN1","tetraspanin 1","---","---","cell motility /// cell adhesion /// cell proliferation","---","membrane /// integral to membrane /// integral to membrane","cell adhesion:cell cycle,proliferation",2.7029,1,0.1885,0,0.1654,0.723]
[34,17,"217580_X_AT","---","Transcribed locus","---","---","---","---","---","unknown",4.9861,1,0,-1,0.3214,0.4821]
[34,18,"216694_AT","---","---","---","---","---","---","---","unknown",3.4375,1,0,-1,0.3794,0.4012]
[34,19,"204213_AT","PIGR","polymeric immunoglobulin receptor","---","---","protein secretion","receptor activity /// protein binding /// protein transporter activity","integral to plasma membrane /// membrane /// integral to membrane",null,2.6813,1,0,-1,0.2851,0.5354]
[34,20,"211066_X_AT","PCDHGA1 /// PCDHGA10 /// PCDHGA11 /// PCDHGA12 /// PCDHGA2 /// PCDHGA3 /// PCDHGA4 /// PCDHGA5 /// PCDHGA6 /// PCDHGA7 /// PCDHGA8 /// PCDHGA9 /// PCDHGB1 /// PCDHGB2 /// PCDHGB3 /// PCDHGB4 /// PCDHGB5 /// PCDHGB6 /// PCDHGB7 /// PCDHGC3 /// PCDHGC4 /// PCDHGC5","protocadherin gamma subfamily C, 3 /// protocadherin gamma subfamily B, 4 /// protocadherin gamma subfamily A, 8 /// protocadherin gamma subfamily A, 12 /// protocadherin gamma subfamily C, 5 /// protocadherin gamma subfamily C, 4 /// protocadherin gamma subfamily B, 7 /// protocadherin gamma subfamily B, 6 /// protocadherin gamma subfamily B, 5 /// protocadherin gamma subfamily B, 3 /// protocadherin gamma subfamily B, 2 /// protocadherin gamma subfamily B, 1 /// protocadherin gamma subfamily A, 11 /// protocadherin gamma subfamily A, 10 /// protocadherin gamma subfamily A, 9 /// protocadherin gamma subfamily A, 7 /// protocadherin gamma subfamily A, 6 /// protocadherin gamma subfamily A, 5 /// protocadherin gamma subfamily A, 4 /// protocadherin gamma subfamily A, 3 /// protocadherin gamma subfamily A, 2 /// protocadherin gamma subfamily A, 1","---","---","cell adhesion /// cell adhesion /// homophilic cell adhesion /// calcium-dependent cell-cell adhesion","calcium ion binding /// protein binding","membrane fraction /// membrane /// membrane /// integral to membrane","cell adhesion",1.6334,1,0.3752,-2,0.0388,0.9342]
[34,21,"215543_S_AT","LARGE","like-glycosyltransferase","---","---","N-acetylglucosamine metabolic process /// protein amino acid glycosylation /// glycosphingolipid biosynthetic process /// glycoprotein biosynthetic process /// carbohydrate biosynthetic process /// muscle maintenance","acetylglucosaminyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups /// transferase activity, transferring glycosyl groups /// transferase activity, transferring hexosyl groups","membrane /// integral to membrane /// integral to Golgi membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",3.1037,1,0.2483,-3,0.2355,0.6112]
[34,22,"217044_S_AT","PLEKHG3","pleckstrin homology domain containing, family G (with RhoGef domain) member 3","---","---","regulation of Rho protein signal transduction","guanyl-nucleotide exchange factor activity /// Rho guanyl-nucleotide exchange factor activity","intracellular","signal transduction,signaling pathway",3.4012,1,0,-1,0.3965,0.3786]
[34,23,"208335_S_AT","DARC","Duffy blood group, chemokine receptor","GPCRDB_Other /// GPCRDB_Other /// GPCRDB_Other /// Peptide_GPCRs /// Peptide_GPCRs /// Peptide_GPCRs","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Other/Hs_GPCRDB_Other.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Other/Hs_GPCRDB_Other.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Other/Hs_GPCRDB_Other.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Peptide_GPCRs/Hs_Peptide_GPCRs.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Peptide_GPCRs/Hs_Peptide_GPCRs.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Peptide_GPCRs/Hs_Peptide_GPCRs.htm","defense response /// cell adhesion /// homophilic cell adhesion /// heterophilic cell adhesion /// signal transduction /// G-protein coupled receptor protein signaling pathway","rhodopsin-like receptor activity /// signal transducer activity /// receptor activity /// receptor activity /// transmembrane receptor activity /// G-protein coupled receptor activity /// chemokine receptor activity /// calcium ion binding /// protein binding /// protein binding /// protein homodimerization activity","plasma membrane /// intercellular junction /// membrane /// integral to membrane /// cell junction","cell adhesion:signal transduction,signaling pathway",3.2861,1,0,0,0.2967,0.5183]
[34,24,"219652_S_AT","CXorf36","chromosome X open reading frame 36","---","---","---","---","---","unknown",2.7615,1,0,-3,0.2519,0.5858]
[34,25,"215261_AT","---","Clone 23578 mRNA sequence","---","---","---","---","---","unknown",2.6473,-1,1.139,-3,0.5798,0.1725]
[34,26,"215607_X_AT","---","CDNA FLJ11511 fis, clone HEMBA1002189","---","---","---","---","---","unknown",2.4008,-1,1.4292,-3,0.4955,0.2581]
[34,27,"202504_AT","TRIM29","tripartite motif-containing 29","---","---","transcription from RNA polymerase II promoter","transcription factor activity /// protein binding /// zinc ion binding /// metal ion binding","intracellular /// cytoplasm","dna repair,transcription",3.2617,1,0,1,0.4337,0.331]
[34,28,"220691_AT","---","Clone HQ0097 PRO0097","---","---","---","---","---","unknown",3.7392,1,0,1,0.2098,0.6516]
[34,29,"210577_AT","CASR","calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)","GPCRDB_Class_C_Metabotropic_glutamate_pheromone","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_GPCRDB_Class_C_Metabotropic_glutamate_pheromone/Hs_GPCRDB_Class_C_Metabotropic_glutamate_pheromone.htm","ossification /// detection of calcium ion /// cellular calcium ion homeostasis /// signal transduction /// G-protein coupled receptor protein signaling pathway /// G-protein coupled receptor protein signaling pathway /// chemosensory behavior /// anatomical structure morphogenesis","phosphoinositide phospholipase C activity /// signal transducer activity /// receptor activity /// G-protein coupled receptor activity /// G-protein coupled receptor activity /// metabotropic glutamate, GABA-B-like receptor activity","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","signal transduction,signaling pathway",3.0246,1,0,-3,0.3618,0.4251]
[34,30,"210430_X_AT","RHD","Rh blood group, D antigen","---","---","---","---","integral to plasma membrane /// membrane /// integral to membrane /// integral to membrane /// integral to membrane","unknown",3.132,1,0,0,0.225,0.6277]
[34,31,"216702_X_AT","---","Unknown protein","---","---","---","---","---","unknown",2.1791,1,0.0003,3,0.2359,0.6105]
[34,32,"38487_AT","STAB1","stabilin 1","---","---","receptor-mediated endocytosis /// inflammatory response /// cell adhesion /// cell adhesion /// cell-cell signaling /// cell-cell signaling /// negative regulation of angiogenesis /// negative regulation of angiogenesis /// defense response to bacterium /// defense response to bacterium","receptor activity /// low-density lipoprotein receptor activity /// low-density lipoprotein receptor activity /// scavenger receptor activity /// scavenger receptor activity /// protein binding /// hyaluronic acid binding /// bacterial binding /// bacterial binding /// protein disulfide oxidoreductase activity /// low-density lipoprotein binding /// low-density lipoprotein binding","integral to plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","cell adhesion",3.2764,1,0.0002,-1,0.3858,0.3926]
[34,33,"220128_S_AT","NPAL2","NIPA-like domain containing 2","---","---","---","---","membrane /// integral to membrane","unknown",2.9158,1,0.2435,0,0.1637,0.7257]
[34,34,"208189_S_AT","MYO7A","myosin VIIA","---","---","lysosome organization and biogenesis /// visual perception /// visual perception /// sensory perception of sound /// sensory perception of sound /// actin filament-based movement /// eye photoreceptor cell development /// response to stimulus","microfilament motor activity /// nucleotide binding /// motor activity /// motor activity /// motor activity /// actin binding /// binding /// protein binding /// calmodulin binding /// calmodulin binding /// ATP binding /// protein dimerization activity","photoreceptor outer segment /// photoreceptor inner segment /// cytoplasm /// lysosomal membrane /// cytosol /// cytoskeleton /// myosin complex /// synapse",null,3.3521,1,0,-1,0.2458,0.5951]
[34,35,"208519_X_AT","GNRH2","gonadotropin-releasing hormone 2","---","---","signal transduction /// multicellular organismal development","hormone activity /// hormone activity","extracellular region /// soluble fraction","signal transduction,signaling pathway",4.1084,1,0.7557,-1,0.4441,0.3182]
[34,36,"213380_X_AT","MSTP9","macrophage stimulating, pseudogene 9","---","---","proteolysis","serine-type endopeptidase activity","---","proteolysis",1.2312,1,0.9029,-2,0.1654,0.723]
[34,37,"212285_S_AT","AGRN","agrin","---","---","signal transduction /// acetylcholine receptor signaling, muscarinic pathway /// synaptic transmission /// receptor clustering /// receptor clustering /// clustering of voltage-gated sodium channels /// synapse organization and biogenesis","structural constituent of cytoskeleton /// protein binding /// laminin binding","proteinaceous extracellular matrix /// basal lamina /// basal lamina","signal transduction,signaling pathway",1.7633,1,0,-3,0.2367,0.6093]
[34,38,"206936_X_AT","---","---","---","---","---","---","---","unknown",2.9427,1,0,-2,0.423,0.3443]
[34,39,"217708_X_AT","---","Transcribed locus","---","---","---","---","---","unknown",4.2715,1,0.0001,3,0.3548,0.4349]
[34,40,"202652_AT","APBB1","amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)","---","---","cell cycle arrest /// signal transduction /// axonogenesis /// negative regulation of cell growth /// regulation of transcription /// negative regulation of S phase of mitotic cell cycle /// negative regulation of thymidylate synthase biosynthetic process","beta-amyloid binding /// beta-amyloid binding /// protein binding /// protein binding /// protein binding /// transcription factor binding","nucleus /// lamellipodium /// lamellipodium /// growth cone /// growth cone /// synapse /// synapse","dna repair,transcription:cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",3.2901,1,0.5271,-3,0.1727,0.7112]
[34,41,"209062_X_AT","NCOA3","nuclear receptor coactivator 3","---","---","transcription /// transcription /// regulation of transcription, DNA-dependent /// signal transduction /// androgen receptor signaling pathway /// regulation of transcription /// positive regulation of transcription, DNA-dependent","transcription coactivator activity /// transcription coactivator activity /// histone acetyltransferase activity /// histone acetyltransferase activity /// signal transducer activity /// receptor activity /// protein binding /// acyltransferase activity /// transferase activity /// transcription regulator activity /// nuclear hormone receptor binding /// thyroid hormone receptor binding /// androgen receptor binding","nucleus /// nucleus /// cytoplasm","dna repair,transcription:signal transduction,signaling pathway",2.2874,1,0,1,0.2883,0.5307]
[34,42,"204574_S_AT","MMP19","matrix metallopeptidase 19","Matrix_Metalloproteinases /// Matrix_Metalloproteinases","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Matrix_Metalloproteinases/Hs_Matrix_Metalloproteinases.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Matrix_Metalloproteinases/Hs_Matrix_Metalloproteinases.htm","peptidoglycan metabolic process /// angiogenesis /// proteolysis /// proteolysis /// multicellular organismal development /// cell differentiation /// collagen catabolic process","metalloendopeptidase activity /// calcium ion binding /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// metal ion binding","proteinaceous extracellular matrix /// proteinaceous extracellular matrix","cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:proteolysis",2.3081,1,0.0007,-2,0.1933,0.6779]
[34,43,"205813_S_AT","MAT1A","methionine adenosyltransferase I, alpha","---","---","amino acid metabolic process /// one-carbon compound metabolic process","nucleotide binding /// magnesium ion binding /// methionine adenosyltransferase activity /// methionine adenosyltransferase activity /// ATP binding /// transferase activity /// potassium ion binding /// metal ion binding /// cobalt ion binding","---","biosynthesis,metabolism,metabolic process,biosynthetic process",2.7742,1,0,1,0.3883,0.3894]
[34,44,"205291_AT","IL2RB","interleukin 2 receptor, beta","Inflammatory_Response_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Inflammatory_Response_Pathway/Hs_Inflammatory_Response_Pathway.htm","protein complex assembly /// signal transduction /// cytokine and chemokine mediated signaling pathway /// positive regulation of survival gene product activity","receptor activity /// hematopoietin/interferon-class (D200-domain) cytokine receptor activity /// interleukin-2 receptor activity /// interleukin-2 receptor activity /// interleukin-2 binding /// interleukin-2 binding","plasma membrane /// integral to plasma membrane /// external side of plasma membrane /// external side of plasma membrane /// membrane /// integral to membrane","signal transduction,signaling pathway",3.5702,1,0,-2,0.2766,0.5481]
[34,45,"202729_S_AT","LTBP1","latent transforming growth factor beta binding protein 1","TGF_Beta_Signaling_Pathway /// TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","---","transforming growth factor beta receptor activity /// calcium ion binding /// protein binding /// growth factor binding","proteinaceous extracellular matrix /// proteinaceous extracellular matrix","unknown",1.6431,1,0.6086,1,-0.0343,0.9418]
[34,46,"208779_X_AT","DDR1","discoidin domain receptor family, member 1","---","---","protein amino acid phosphorylation /// cell adhesion /// cell adhesion /// transmembrane receptor protein tyrosine kinase signaling pathway","nucleotide binding /// protein kinase activity /// protein-tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// receptor activity /// ATP binding /// kinase activity /// transferase activity","integral to plasma membrane /// membrane /// integral to membrane","cell adhesion:signal transduction,signaling pathway",1.3102,1,0.0008,1,0.2778,0.5464]
[34,47,"208983_S_AT","PECAM1","platelet/endothelial cell adhesion molecule (CD31 antigen)","---","---","cell motility /// cell adhesion /// signal transduction /// cell recognition","protein binding","plasma membrane /// intercellular junction /// membrane /// integral to membrane","cell adhesion:signal transduction,signaling pathway",2.2255,1,1.9684,-1,-0.5058,0.2468]
[34,48,"204526_S_AT","TBC1D8","TBC1 domain family, member 8 (with GRAM domain)","Cell_cycle_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm","circulation /// positive regulation of cell proliferation /// regulation of Rab GTPase activity","GTPase activator activity /// Rab GTPase activator activity /// calcium ion binding","intracellular /// membrane","cell cycle,proliferation",1.6357,1,0.0009,-3,0.4394,0.3239]
[]
[null,null,35]
[35,1,"203729_AT","EMP3","epithelial membrane protein 3","---","---","multicellular organismal development /// cell death /// negative regulation of cell proliferation /// cell growth","---","membrane fraction /// membrane /// integral to membrane","cell growth,differentiation:cell cycle,proliferation",5.1488,1,0,-2,-0.1201,0.7976]
[35,2,"207348_S_AT","LIG3","ligase III, DNA, ATP-dependent","---","---","DNA replication /// DNA repair /// DNA repair /// DNA recombination /// response to DNA damage stimulus /// cell cycle /// meiotic recombination /// spermatogenesis /// cell division","nucleotide binding /// DNA binding /// DNA binding /// DNA ligase activity /// DNA ligase (ATP) activity /// ATP binding /// zinc ion binding /// ligase activity /// metal ion binding","intracellular /// nucleus /// nucleus","dna repair,transcription:cell cycle,proliferation:dna replication",2.5334,-1,1.7287,-2,0.8643,0.0121]
[35,3,"208944_AT","TGFBR2","transforming growth factor, beta receptor II (70/80kDa)","TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","protein amino acid phosphorylation /// transmembrane receptor protein serine/threonine kinase signaling pathway /// positive regulation of cell proliferation","nucleotide binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// transmembrane receptor protein serine/threonine kinase activity /// receptor signaling protein serine/threonine kinase activity /// receptor activity /// transforming growth factor beta receptor activity /// transforming growth factor beta receptor activity, type II /// protein binding /// ATP binding /// kinase activity /// transferase activity /// manganese ion binding /// metal ion binding","membrane /// integral to membrane /// integral to membrane","cell cycle,proliferation:signal transduction,signaling pathway",7.9339,1,0,-2,-0.3063,0.504]
[35,4,"204174_AT","ALOX5AP","arachidonate 5-lipoxygenase-activating protein","Eicosanoid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Eicosanoid_Synthesis/Hs_Eicosanoid_Synthesis.htm","leukotriene metabolic process /// inflammatory response /// leukotriene biosynthetic process","binding /// enzyme activator activity /// enzyme activator activity","membrane fraction /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",7.9574,1,1.7257,4,-0.6171,0.1399]
[35,5,"214527_S_AT","PQBP1","polyglutamine binding protein 1","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent","DNA binding /// transcription coactivator activity /// protein binding","nucleus","dna repair,transcription",5.8076,1,0,-2,0.2142,0.6447]
[35,6,"211297_S_AT","CDK7","cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)","G1_to_S_cell_cycle_Reactome /// RNA_transcription_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_RNA_transcription_Reactome/Hs_RNA_transcription_Reactome.htm","regulation of progression through cell cycle /// regulation of cyclin-dependent protein kinase activity /// DNA repair /// transcription /// regulation of transcription, DNA-dependent /// transcription initiation from RNA polymerase II promoter /// protein amino acid phosphorylation /// response to DNA damage stimulus /// cell cycle /// cell proliferation /// androgen receptor signaling pathway /// positive regulation of transcription, DNA-dependent /// cell division","nucleotide binding /// transcription coactivator activity /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// cyclin-dependent protein kinase activity /// ATP binding /// kinase activity /// transferase activity /// androgen receptor binding","nucleus /// nucleus","dna repair,transcription:cell cycle,proliferation:signal transduction,signaling pathway",5.7666,1,0,-1,-0.2568,0.5783]
[35,7,"203112_S_AT","WHSC2","Wolf-Hirschhorn syndrome candidate 2","---","---","transcription /// regulation of transcription, DNA-dependent /// multicellular organismal development","---","---","dna repair,transcription",6.7977,1,1.2505,-2,-0.1078,0.8181]
[35,8,"220761_S_AT","TAOK3","TAO kinase 3","---","---","MAPKKK cascade /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// JNK cascade /// negative regulation of JNK cascade /// positive regulation of JNK cascade /// protein amino acid autophosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// protein kinase inhibitor activity /// ATP binding /// ATP binding /// kinase activity /// transferase activity /// transferase activity","cytoplasm /// membrane",null,5.7677,1,1.7926,2,-0.4027,0.3705]
[35,9,"219006_AT","C6orf66","chromosome 6 open reading frame 66","---","---","---","---","---","unknown",8.7618,1,0,-1,-0.1654,0.723]
[35,10,"218481_AT","EXOSC5","exosome component 5","---","---","rRNA processing /// rRNA processing /// RNA processing","3'-5'-exoribonuclease activity /// 3'-5'-exoribonuclease activity /// RNA binding /// nuclease activity /// exonuclease activity /// protein binding /// hydrolase activity","exosome (RNase complex) /// nucleolus /// cytoplasm",null,5.0176,1,1.3312,2,0.2329,0.6152]
[35,11,"213427_AT","RPP40","ribonuclease P/MRP 40kDa subunit","---","---","tRNA processing","ribonuclease P activity /// ribonuclease P activity /// protein binding /// hydrolase activity","nucleus /// nucleolar ribonuclease P complex",null,4.1419,-1,0.5358,-4,0.2667,0.5631]
[35,12,"201490_S_AT","PPIF","peptidylprolyl isomerase F (cyclophilin F)","---","---","protein folding","peptidyl-prolyl cis-trans isomerase activity /// isomerase activity /// peptide binding","membrane fraction /// mitochondrion",null,6.0564,1,1.2647,4,-0.1861,0.6895]
[35,13,"219098_AT","MYBBP1A","MYB binding protein (P160) 1a","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// nucleocytoplasmic transport","DNA binding /// DNA-directed DNA polymerase activity /// protein binding /// transcription factor binding","nucleus /// nucleolus /// cytoplasm /// cytoplasm /// NLS-dependent protein nuclear import complex","dna repair,transcription:transport,ion channel",4.272,1,0,-2,0.3049,0.5061]
[35,14,"214448_X_AT","NFKBIB","nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta","Apoptosis /// Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","transcription /// signal transduction","transcription coactivator activity /// signal transducer activity /// receptor activity /// protein binding","cytoplasm","dna repair,transcription:signal transduction,signaling pathway",3.0975,-1,0,-2,0.6892,0.0867]
[35,15,"208926_AT","NEU1","sialidase 1 (lysosomal sialidase)","---","---","metabolic process","exo-alpha-sialidase activity /// exo-alpha-sialidase activity /// protein binding /// hydrolase activity /// hydrolase activity, acting on glycosyl bonds","lysosome /// lysosome /// membrane /// cytoplasmic vesicle","biosynthesis,metabolism,metabolic process,biosynthetic process",2.9809,-1,1.1991,-4,0.8645,0.012]
[35,16,"201948_AT","GNL2","guanine nucleotide binding protein-like 2 (nucleolar)","---","---","ribosome biogenesis and assembly","nucleotide binding /// GTPase activity /// protein binding /// GTP binding /// GTP binding","intracellular /// nucleus",null,5.4023,1,0,2,0.1873,0.6876]
[35,17,"218689_AT","FANCF","Fanconi anemia, complementation group F","---","---","DNA repair /// response to DNA damage stimulus","protein binding","---","dna repair,transcription",5.2502,1,0,-1,-0.0996,0.8318]
[35,18,"209051_S_AT","RALGDS","ral guanine nucleotide dissociation stimulator","---","---","signal transduction /// small GTPase mediated signal transduction /// small GTPase mediated signal transduction /// regulation of small GTPase mediated signal transduction","small GTPase regulator activity /// small GTPase regulator activity /// guanyl-nucleotide exchange factor activity","intracellular","signal transduction,signaling pathway",3.5516,-1,1.2401,-1,0.9311,0.0023]
[35,19,"218682_S_AT","SLC4A1AP","solute carrier family 4 (anion exchanger), member 1, adaptor protein","---","---","---","double-stranded RNA binding","intracellular /// cytoplasm","unknown",4.4875,1,0,2,-0.0448,0.9241]
[35,20,"202593_S_AT","MIR16","membrane interacting protein of RGS16","---","---","glycerol metabolic process /// lipid metabolic process","glycerophosphodiester phosphodiesterase activity /// glycerophosphodiester phosphodiesterase activity /// hydrolase activity /// glycerophosphoinositol glycerophosphodiesterase activity","cytoplasm /// membrane /// integral to membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",4.0838,1,0,-2,0.4006,0.3732]
[35,21,"201746_AT","TP53","tumor protein p53 (Li-Fraumeni syndrome)","Apoptosis /// Apoptosis_GenMAPP /// Cell_cycle_KEGG /// G1_to_S_cell_cycle_Reactome","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Cell_cycle_KEGG/Hs_Cell_cycle_KEGG.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_G1_to_S_cell_cycle_Reactome/Hs_G1_to_S_cell_cycle_Reactome.htm","regulation of progression through cell cycle /// base-excision repair /// nucleotide-excision repair /// transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// protein complex assembly /// apoptosis /// apoptosis /// response to DNA damage stimulus /// response to DNA damage stimulus /// ER overload response /// cell cycle /// cell cycle arrest /// multicellular organismal development /// cell aging /// protein localization /// cell proliferation /// induction of apoptosis by intracellular signals /// caspase activation via cytochrome c /// cell differentiation /// negative regulation of cell growth /// cellular response to glucose starvation /// DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis /// regulation of apoptosis /// negative regulation of progression through cell cycle /// regulation of mitochondrial membrane permeability /// negative regulation of helicase activity /// protein tetramerization","DNA strand annealing activity /// DNA binding /// DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// nuclease activity /// copper ion binding /// protein binding /// ATP binding /// zinc ion binding /// zinc ion binding /// enzyme binding /// metal ion binding /// protein heterodimerization activity /// protein N-terminus binding","insoluble fraction /// nucleus /// nucleus /// nucleoplasm /// nucleolus /// cytoplasm /// cytoplasm /// mitochondrion /// endoplasmic reticulum /// nuclear matrix","dna repair,transcription:cell growth,differentiation:apoptosis:cell cycle,proliferation:signal transduction,signaling pathway",5.0265,-1,0.504,-4,0.5769,0.1751]
[35,22,"219117_S_AT","FKBP11","FK506 binding protein 11, 19 kDa","---","---","protein folding","peptidyl-prolyl cis-trans isomerase activity /// isomerase activity","membrane /// integral to membrane",null,6.0786,1,0,2,-0.0784,0.8673]
[35,23,"212900_AT","SEC24A","SEC24 related gene family, member A (S. cerevisiae)","---","---","transport /// intracellular protein transport /// ER to Golgi vesicle-mediated transport /// ER to Golgi vesicle-mediated transport /// protein transport","protein binding /// zinc ion binding","cytoplasm /// endoplasmic reticulum /// COPII vesicle coat /// COPII vesicle coat","transport,ion channel",5.9411,1,0,-1,0.0091,0.9845]
[35,24,"205633_S_AT","ALAS1","aminolevulinate, delta-, synthase 1","Heme_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Heme_Biosynthesis/Hs_Heme_Biosynthesis.htm","heme biosynthetic process /// heme biosynthetic process /// metabolic process /// biosynthetic process /// tetrapyrrole biosynthetic process","catalytic activity /// 5-aminolevulinate synthase activity /// acyltransferase activity /// transferase activity /// transferase activity, transferring nitrogenous groups /// pyridoxal phosphate binding","mitochondrion","biosynthesis,metabolism,metabolic process,biosynthetic process",4.5542,1,0,-2,0.3508,0.4404]
[35,25,"218761_AT","RNF111","ring finger protein 111","---","---","ubiquitin cycle /// multicellular organismal development /// pattern specification process","protein binding /// zinc ion binding /// ligase activity /// metal ion binding","nucleus /// cytoplasm",null,5.6475,1,0,-4,-0.1187,0.7999]
[35,26,"212422_AT","PDCD11","programmed cell death 11","---","---","rRNA processing /// RNA processing","RNA binding /// binding /// protein binding /// transcription factor binding","intracellular /// nucleus /// cytosol",null,3.7615,-1,0,-2,0.5901,0.1631]
[35,27,"204327_S_AT","ZNF202","zinc finger protein 202","---","---","negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent /// lipid metabolic process","nucleic acid binding /// DNA binding /// transcription factor activity /// transcription factor activity /// specific RNA polymerase II transcription factor activity /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription:biosynthesis,metabolism,metabolic process,biosynthetic process",3.8997,-1,0,2,0.5081,0.2444]
[35,28,"212457_AT","TFE3","transcription factor binding to IGHM enhancer 3","TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// regulation of transcription","DNA binding /// transcription factor activity /// protein binding /// transcription regulator activity","nucleus","dna repair,transcription",4.0232,-1,0.8354,4,0.6712,0.0988]
[35,29,"211563_S_AT","C19orf2","chromosome 19 open reading frame 2","---","---","regulation of transcription from RNA polymerase II promoter /// protein folding /// response to virus","transcription corepressor activity /// unfolded protein binding","nucleus /// DNA-directed RNA polymerase II, core complex /// cytoplasm /// prefoldin complex","dna repair,transcription",5.0672,1,0,-4,0.0331,0.9439]
[35,30,"202805_S_AT","ABCC1","ATP-binding cassette, sub-family C (CFTR/MRP), member 1","Irinotecan_pathway_PharmGKB /// Irinotecan_pathway_PharmGKB","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Irinotecan_pathway_PharmGKB/Hs_Irinotecan_pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Irinotecan_pathway_PharmGKB/Hs_Irinotecan_pathway_PharmGKB.htm","transport /// transport /// response to drug","nucleotide binding /// transporter activity /// transporter activity /// ATP binding /// ATP binding /// ATPase activity /// ATPase activity /// nucleoside-triphosphatase activity /// ATPase activity, coupled to transmembrane movement of substances /// ATPase activity, coupled to transmembrane movement of substances","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane","transport,ion channel",3.331,-1,1.1005,-4,0.7463,0.054]
[35,31,"212871_AT","MAPKAPK5","mitogen-activated protein kinase-activated protein kinase 5","---","---","protein amino acid phosphorylation /// response to stress /// signal transduction","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// MAP kinase kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity","nucleus /// cytoplasm","signal transduction,signaling pathway",4.6664,-1,0,-1,0.4797,0.276]
[35,32,"213400_S_AT","TBL1X","transducin (beta)-like 1X-linked","---","---","transcription /// regulation of transcription, DNA-dependent /// ubiquitin cycle /// signal transduction /// visual perception /// sensory perception of sound /// sensory perception of sound","---","---","dna repair,transcription:signal transduction,signaling pathway",5.0896,1,1.8767,4,0.2126,0.6472]
[35,33,"211708_S_AT","SCD","stearoyl-CoA desaturase (delta-9-desaturase)","Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","lipid metabolic process /// fatty acid biosynthetic process /// lipid biosynthetic process","stearoyl-CoA 9-desaturase activity /// stearoyl-CoA 9-desaturase activity /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",4.1627,1,1.3327,-2,0.5351,0.2159]
[35,34,"210692_S_AT","SLC43A3","solute carrier family 43, member 3","---","---","---","---","---","unknown",3.867,-1,0.9926,-4,0.7083,0.0748]
[35,35,"204593_S_AT","SMCR7L","Smith-Magenis syndrome chromosome region, candidate 7-like","---","---","---","---","---","unknown",5.5416,-1,0,2,-0.0173,0.9706]
[35,36,"204206_AT","MNT","MAX binding protein","---","---","regulation of progression through cell cycle /// transcription /// regulation of transcription, DNA-dependent /// transcription from RNA polymerase II promoter /// multicellular organismal development /// negative regulation of cell proliferation /// regulation of transcription","DNA binding /// transcription factor activity /// transcription coactivator activity /// transcription corepressor activity /// transcription regulator activity","nucleus","dna repair,transcription:cell cycle,proliferation",4.7477,1,0,-2,0.0923,0.8439]
[35,37,"211162_X_AT","SCD","stearoyl-CoA desaturase (delta-9-desaturase)","Fatty_Acid_Synthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Fatty_Acid_Synthesis/Hs_Fatty_Acid_Synthesis.htm","lipid metabolic process /// fatty acid biosynthetic process /// lipid biosynthetic process","stearoyl-CoA 9-desaturase activity /// stearoyl-CoA 9-desaturase activity /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",4.1706,1,0,-2,0.503,0.2499]
[35,38,"221485_AT","B4GALT5","UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5","---","---","carbohydrate metabolic process","galactosyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups /// manganese ion binding /// metal ion binding","membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",5.5546,1,0,2,0.2709,0.5567]
[35,39,"213181_S_AT","MOCS1","molybdenum cofactor synthesis 1","---","---","Mo-molybdopterin cofactor biosynthetic process /// Mo-molybdopterin cofactor biosynthetic process /// metabolic process","nucleotide binding /// catalytic activity /// iron ion binding /// GTP binding /// molybdenum ion binding /// metal ion binding /// iron-sulfur cluster binding /// 4 iron, 4 sulfur cluster binding","nucleus /// molybdopterin synthase complex","biosynthesis,metabolism,metabolic process,biosynthetic process",4.4735,-1,0.6544,2,0.7185,0.0689]
[35,40,"203045_AT","NINJ1","ninjurin 1","---","---","protein folding /// transport /// cell adhesion /// cell adhesion /// nervous system development /// protein transport /// tissue regeneration","protein binding /// heat shock protein binding /// unfolded protein binding","endoplasmic reticulum /// membrane /// integral to membrane","cell adhesion:transport,ion channel",3.6756,-1,0.5206,-4,0.7117,0.0729]
[35,41,"209409_AT","GRB10","growth factor receptor-bound protein 10","---","---","signal transduction /// intracellular signaling cascade /// cell-cell signaling /// insulin receptor signaling pathway","SH3/SH2 adaptor activity /// protein binding","cytoplasm /// plasma membrane","signal transduction,signaling pathway",12.6155,1,0,4,-0.4408,0.3222]
[35,42,"201797_S_AT","VARS","valyl-tRNA synthetase","---","---","translation /// translational elongation /// tRNA aminoacylation for protein translation /// valyl-tRNA aminoacylation","nucleotide binding /// aminoacyl-tRNA ligase activity /// valine-tRNA ligase activity /// valine-tRNA ligase activity /// protein binding /// ATP binding /// ligase activity","intracellular /// cytoplasm",null,6.0734,1,0,-2,0.444,0.3183]
[35,43,"201017_AT","EIF1AX","eukaryotic translation initiation factor 1A, X-linked","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation","RNA binding /// translation initiation factor activity /// translation factor activity, nucleic acid binding","eukaryotic translation initiation factor 4F complex",null,7.1602,1,0,4,0.0161,0.9726]
[35,44,"212458_AT","SPRED2","sprouty-related, EVH1 domain containing 2","---","---","inactivation of MAPK activity /// multicellular organismal development /// regulation of signal transduction","stem cell factor receptor binding /// protein binding","membrane","signal transduction,signaling pathway",7.3121,1,0,-1,0.0564,0.9044]
[35,45,"219648_AT","MREG","melanoregulin","---","---","---","---","membrane","unknown",12.6759,1,0,2,0.5296,0.2215]
[35,46,"218360_AT","RAB22A","RAB22A, member RAS oncogene family","---","---","transport /// endocytosis /// endosome organization and biogenesis /// small GTPase mediated signal transduction /// protein transport","nucleotide binding /// GTPase activity /// protein binding /// protein binding /// GTP binding /// GTP binding","endosome /// early endosome /// plasma membrane /// membrane","transport,ion channel:signal transduction,signaling pathway",11.1516,-1,1.6859,-1,0.4327,0.3322]
[35,47,"214452_AT","BCAT1","branched chain aminotransferase 1, cytosolic","---","---","G1/S transition of mitotic cell cycle /// metabolic process /// cell proliferation /// amino acid biosynthetic process /// branched chain family amino acid metabolic process /// branched chain family amino acid biosynthetic process /// branched chain family amino acid biosynthetic process","catalytic activity /// branched-chain-amino-acid transaminase activity /// branched-chain-amino-acid transaminase activity /// transaminase activity /// transferase activity","cytoplasm /// cytosol","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",14.9608,1,0,-2,-0.0815,0.8621]
[35,48,"206067_S_AT","WT1","Wilms tumor 1","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// cell cycle /// negative regulation of progression through cell cycle","nucleic acid binding /// DNA binding /// transcription factor activity /// transcription factor activity /// zinc ion binding /// metal ion binding","intracellular /// nucleus /// nucleus","dna repair,transcription:cell cycle,proliferation",13.3242,1,0,-4,-0.4193,0.3491]
[35,49,"209325_S_AT","RGS16","regulator of G-protein signaling 16","Calcium_regulation_in_cardiac_cells /// Smooth_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Calcium_regulation_in_cardiac_cells/Hs_Calcium_regulation_in_cardiac_cells.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm","visual perception /// regulation of G-protein coupled receptor protein signaling pathway /// negative regulation of signal transduction","signal transducer activity /// GTPase activator activity /// calmodulin binding","---","signal transduction,signaling pathway",10.5509,-1,1.4457,-1,0.7899,0.0346]
[35,50,"201464_X_AT","JUN","jun oncogene","Apoptosis /// Apoptosis_GenMAPP /// MAPK_Cascade /// Smooth_muscle_contraction /// TGF_Beta_Signaling_Pathway /// Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_MAPK_Cascade/Hs_MAPK_Cascade.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Smooth_muscle_contraction/Hs_Smooth_muscle_contraction.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","regulation of progression through cell cycle /// transcription /// regulation of transcription, DNA-dependent /// cellular process /// leading edge cell differentiation /// regulation of transcription /// positive regulation of transcription from RNA polymerase II promoter","DNA binding /// DNA binding /// transcription factor activity /// transcription factor activity /// RNA polymerase II transcription factor activity /// protein binding /// protein binding /// sequence-specific DNA binding /// protein dimerization activity","nuclear chromosome /// nucleus /// transcription factor complex","dna repair,transcription:cell growth,differentiation:cell cycle,proliferation",13.5222,-1,1.8199,-1,0.4424,0.3202]
[35,51,"209795_AT","CD69","CD69 molecule","---","---","defense response /// cell surface receptor linked signal transduction","transmembrane receptor activity /// sugar binding","integral to plasma membrane /// external side of plasma membrane /// membrane /// integral to membrane","signal transduction,signaling pathway",20.0131,-1,1.7985,-1,0.1201,0.7976]
[]
[null,null,36]
[36,1,"212252_AT","CAMKK2","calcium/calmodulin-dependent protein kinase kinase 2, beta","---","---","MAPKKK cascade /// protein amino acid phosphorylation /// protein amino acid phosphorylation /// calcium-mediated signaling /// regulation of protein kinase activity /// positive regulation of transcription /// protein amino acid autophosphorylation","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein-tyrosine kinase activity /// calcium ion binding /// calmodulin binding /// calmodulin binding /// ATP binding /// kinase activity /// transferase activity","intracellular /// cytoplasm","dna repair,transcription",2.5227,-1,1.6872,-4,0.2518,0.5859]
[36,2,"203846_AT","TRIM32","tripartite motif-containing 32","---","---","ubiquitin cycle","transcription coactivator activity /// protein binding /// protein binding /// zinc ion binding /// ligase activity /// metal ion binding","intracellular /// nucleus /// nucleus",null,16.2781,1,0.0004,2,0.7962,0.0322]
[36,3,"213161_AT","C9orf97","chromosome 9 open reading frame 97","Striated_muscle_contraction","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Striated_muscle_contraction/Hs_Striated_muscle_contraction.htm","---","---","---","unknown",5.746,-1,0,4,0.5667,0.1846]
[36,4,"221735_AT","WDR48","WD repeat domain 48","---","---","---","---","lysosome","unknown",13.7242,-1,0,4,0.3543,0.4356]
[36,5,"210417_S_AT","PI4KB","phosphatidylinositol 4-kinase, catalytic, beta","---","---","phosphatidylinositol biosynthetic process /// receptor-mediated endocytosis /// signal transduction","1-phosphatidylinositol 4-kinase activity /// 1-phosphatidylinositol 4-kinase activity /// protein binding /// kinase activity /// transferase activity /// phosphotransferase activity, alcohol group as acceptor","cytoplasm /// mitochondrion /// endosome /// endoplasmic reticulum /// membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:signal transduction,signaling pathway",12.3807,-1,0,-4,0.7447,0.0548]
[36,6,"219256_S_AT","SH3TC1","SH3 domain and tetratricopeptide repeats 1","---","---","---","binding","---","unknown",10.0863,-1,1.9483,2,0.6426,0.1196]
[36,7,"218023_S_AT","FAM53C","family with sequence similarity 53, member C","---","---","---","---","---","unknown",12.7655,1,0.809,6,0.4936,0.2603]
[36,8,"207622_S_AT","ABCF2","ATP-binding cassette, sub-family F (GCN20), member 2","---","---","transport","nucleotide binding /// transporter activity /// ATP binding /// ATP binding /// ATPase activity /// nucleoside-triphosphatase activity","mitochondrial envelope /// ATP-binding cassette (ABC) transporter complex","transport,ion channel",10.8285,-1,0,6,0.643,0.1193]
[36,9,"204234_S_AT","ZNF195","zinc finger protein 195","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// DNA binding /// zinc ion binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus /// nucleus","dna repair,transcription",13.3273,1,0,-6,0.6754,0.0959]
[36,10,"216262_S_AT","TGIF2","TGFB-induced factor homeobox 2","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent /// regulation of transcription","DNA binding /// transcription factor activity /// transcription factor activity /// sequence-specific DNA binding","nucleus /// nucleus","dna repair,transcription",6.2786,-1,0,4,0.1807,0.6982]
[36,11,"41386_I_AT","JMJD3","jumonji domain containing 3","---","---","---","binding","---","unknown",9.7852,-1,0,2,0.5614,0.1897]
[36,12,"212563_AT","BOP1 /// LOC727967","block of proliferation 1 /// similar to block of proliferation 1","---","---","rRNA processing /// ribosome biogenesis and assembly","protein binding","---",null,8.5283,1,0,0,0.3301,0.4696]
[36,13,"202387_AT","BAG1","BCL2-associated athanogene","Ribosomal_Proteins /// Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/molecular_function_GenMAPP/Rn_Ribosomal_Proteins/Rn_Ribosomal_Proteins.htm","translation /// translation /// protein folding /// protein modification process /// apoptosis /// anti-apoptosis /// cell surface receptor linked signal transduction","structural constituent of ribosome /// structural constituent of ribosome /// receptor signaling protein activity /// protein binding /// protein binding","intracellular /// nucleus /// cytoplasm /// cytoplasm /// ribosome /// ribosome /// membrane /// integral to membrane /// ribonucleoprotein complex /// protein complex","apoptosis:signal transduction,signaling pathway",16.2293,1,0.0006,2,0.7328,0.061]
[36,14,"201937_S_AT","DNPEP","aspartyl aminopeptidase","---","---","proteolysis /// peptide metabolic process","aminopeptidase activity /// aminopeptidase activity /// aminopeptidase I activity /// protein binding /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// aspartyl aminopeptidase activity /// metal ion binding","cytoplasm /// cytoplasm /// vacuole","biosynthesis,metabolism,metabolic process,biosynthetic process:proteolysis",12.2428,-1,0,-4,0.5978,0.1563]
[36,15,"201079_AT","SYNGR2","synaptogyrin 2","---","---","---","---","integral to plasma membrane /// synaptic vesicle /// membrane /// integral to membrane","unknown",10.638,-1,0,2,0.3477,0.4448]
[36,16,"207196_S_AT","TNIP1","TNFAIP3 interacting protein 1","---","---","translation /// defense response /// glycoprotein biosynthetic process /// pathogenesis /// negative regulation of viral genome replication","protein binding /// protein binding","intracellular /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",8.128,-1,0,-6,0.4688,0.2886]
[36,17,"201801_S_AT","SLC29A1","solute carrier family 29 (nucleoside transporters), member 1","---","---","nucleobase, nucleoside, nucleotide and nucleic acid metabolic process /// transport /// nucleoside transport /// nucleoside transport","nucleoside transmembrane transporter activity /// nucleoside transmembrane transporter activity /// protein binding","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",11.5643,-1,0,-4,0.5319,0.2191]
[36,18,"207076_S_AT","ASS1","argininosuccinate synthetase 1","---","---","urea cycle /// urea cycle /// arginine biosynthetic process /// amino acid biosynthetic process","nucleotide binding /// argininosuccinate synthase activity /// protein binding /// ATP binding /// ligase activity","cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",10.9062,-1,0,-6,0.3429,0.4515]
[36,19,"208289_S_AT","EI24","etoposide induced 2.4 mRNA","---","---","induction of apoptosis","---","---","apoptosis",9.539,-1,0,-6,0.7795,0.0388]
[36,20,"201236_S_AT","BTG2","BTG family, member 2","---","---","DNA repair /// transcription /// regulation of transcription, DNA-dependent /// protein amino acid methylation /// response to DNA damage stimulus /// negative regulation of cell proliferation /// anterior/posterior pattern formation","transcription factor activity /// protein binding","---","dna repair,transcription:cell cycle,proliferation",19.5603,1,0,-4,0.8769,0.0096]
[36,21,"221571_AT","TRAF3","TNF receptor-associated factor 3","Apoptosis /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","apoptosis /// induction of apoptosis /// signal transduction /// signal transduction /// regulation of apoptosis","signal transducer activity /// protein binding /// protein binding /// zinc ion binding /// metal ion binding","cytoplasm","apoptosis:signal transduction,signaling pathway",13.1213,-1,0,4,0.4676,0.29]
[36,22,"201560_AT","CLIC4","chloride intracellular channel 4","---","---","transport /// ion transport /// chloride transport /// chloride transport /// cell differentiation /// negative regulation of cell migration","ion channel activity /// voltage-gated ion channel activity /// voltage-gated chloride channel activity /// chloride channel activity /// chloride channel activity /// protein binding /// chloride ion binding","intracellular /// soluble fraction /// cytoplasm /// mitochondrion /// microvillus /// actin cytoskeleton /// membrane /// cytoplasmic vesicle","cell growth,differentiation:transport,ion channel",8.9496,-1,0,-4,0.1147,0.8065]
[36,23,"221877_AT","---","CDNA FLJ38849 fis, clone MESAN2008936","---","---","---","---","---","unknown",13.2221,1,0,-4,0.644,0.1185]
[36,24,"202074_S_AT","OPTN","optineurin","---","---","protein targeting to Golgi /// Golgi organization and biogenesis /// signal transduction /// cell death /// Golgi to plasma membrane protein transport","protein C-terminus binding","cytoplasm /// cytoplasm /// Golgi apparatus","transport,ion channel:signal transduction,signaling pathway",10.7834,-1,0,4,0.9175,0.0036]
[36,25,"207339_S_AT","LTB","lymphotoxin beta (TNF superfamily, member 3)","---","---","immune response /// signal transduction /// cell-cell signaling","receptor binding /// cytokine activity /// tumor necrosis factor receptor binding","extracellular space /// membrane /// integral to membrane","immune response:signal transduction,signaling pathway",11.8856,1,0,-6,0.897,0.0062]
[36,26,"201790_S_AT","DHCR7","7-dehydrocholesterol reductase","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","blood vessel development /// steroid biosynthetic process /// cholesterol biosynthetic process /// cholesterol biosynthetic process /// lipid biosynthetic process /// sterol biosynthetic process /// cell differentiation /// lung development /// regulation of cell proliferation","protein binding /// oxidoreductase activity /// 7-dehydrocholesterol reductase activity /// 7-dehydrocholesterol reductase activity","nuclear outer membrane /// endoplasmic reticulum /// endoplasmic reticulum /// membrane /// integral to membrane","cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation",9.8866,-1,0,6,0.5298,0.2213]
[36,27,"204440_AT","CD83","CD83 molecule","---","---","defense response /// humoral immune response /// signal transduction","---","plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane","immune response:signal transduction,signaling pathway",10.5692,1,0,-2,0.4808,0.2748]
[36,28,"205822_S_AT","HMGCS1","3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)","Cholesterol_Biosynthesis /// Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","acetyl-CoA metabolic process /// lipid metabolic process /// steroid biosynthetic process /// cholesterol biosynthetic process /// lipid biosynthetic process /// sterol biosynthetic process","hydroxymethylglutaryl-CoA synthase activity /// hydroxymethylglutaryl-CoA synthase activity /// transferase activity","soluble fraction /// cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process",12.6168,-1,0,-6,0.4778,0.2782]
[36,29,"202871_AT","TRAF4","TNF receptor-associated factor 4","---","---","apoptosis /// signal transduction /// signal transduction /// multicellular organismal development /// regulation of apoptosis","DNA binding /// protein binding /// zinc ion binding /// metal ion binding","nucleus /// cytoplasm","apoptosis:signal transduction,signaling pathway",17.398,-1,0,-4,0.4741,0.2824]
[36,30,"202643_S_AT","TNFAIP3","tumor necrosis factor, alpha-induced protein 3","---","---","ubiquitin cycle /// apoptosis /// anti-apoptosis /// negative regulation of I-kappaB kinase/NF-kappaB cascade","DNA binding /// protein binding /// peptidase activity /// cysteine-type peptidase activity /// zinc ion binding /// hydrolase activity /// metal ion binding","nucleus /// cytoplasm","apoptosis",18.4161,-1,0,4,0.4105,0.3603]
[]
[null,null,37]
[37,1,"201310_S_AT","C5orf13","chromosome 5 open reading frame 13","Ribosomal_Proteins","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm","translation /// regulation of transforming growth factor beta receptor signaling pathway","tRNA binding /// RNA binding /// structural constituent of ribosome /// protein binding /// protein binding","intracellular /// ribosome /// cytosolic large ribosomal subunit (sensu Eukaryota) /// ribonucleoprotein complex","signal transduction,signaling pathway",0.4488,1,0.7863,2,-0.3633,0.4231]
[37,2,"210950_S_AT","FDFT1","farnesyl-diphosphate farnesyltransferase 1","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","steroid biosynthetic process /// steroid biosynthetic process /// cholesterol biosynthetic process /// isoprenoid biosynthetic process /// lipid biosynthetic process /// biosynthetic process /// sterol biosynthetic process","magnesium ion binding /// catalytic activity /// farnesyl-diphosphate farnesyltransferase activity /// protein binding /// oxidoreductase activity /// transferase activity","endoplasmic reticulum /// membrane /// integral to membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",1.3103,1,0,2,0.6548,0.1104]
[37,3,"208980_S_AT","UBC","ubiquitin C","DNA_replication_Reactome /// DNA_replication_Reactome /// DNA_replication_Reactome /// DNA_replication_Reactome /// DNA_replication_Reactome /// DNA_replication_Reactome /// Proteasome_Degradation /// Proteasome_Degradation /// Proteasome_Degradation /// Proteasome_Degradation /// Proteasome_Degradation /// Ribosomal_Proteins /// Ribosomal_Proteins /// Statin_Pathway_PharmGKB /// Statin_Pathway_PharmGKB","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Mouse/Mm_Contributed_20051212/cellular_process-GenMAPP/Mm_DNA_replication_Reactome/Mm_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_DNA_replication_Reactome/Hs_DNA_replication_Reactome.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/physiological_process-GenMAPP/Hs_Proteasome_Degradation/Hs_Proteasome_Degradation.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Ribosomal_Proteins/Hs_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Rat/Rn_Contributed_20051116/molecular_function_GenMAPP/Rn_Ribosomal_Proteins/Rn_Ribosomal_Proteins.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Statin_Pathway_PharmGKB/Hs_Statin_Pathway_PharmGKB.htm","protein modification process /// transport /// apoptosis /// cell cycle /// cell adhesion /// axon guidance /// cholesterol metabolic process /// protein ubiquitination /// ER-associated protein catabolic process /// long-term strengthening of neuromuscular junction /// proteasomal ubiquitin-dependent protein catabolic process /// positive regulation of transcription /// regulation of synaptic plasticity","receptor activity /// receptor activity /// transporter activity /// protein binding /// transcription regulator activity","integral to membrane of membrane fraction /// membrane fraction /// nucleus /// cytoplasm /// plasma membrane /// integral to plasma membrane /// membrane /// integral to membrane /// caveolar membrane","dna repair,transcription:cell adhesion:biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel:apoptosis:cell cycle,proliferation",1.1005,1,0,2,0.8126,0.0263]
[37,4,"202021_X_AT","EIF1","eukaryotic translation initiation factor 1","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation /// regulation of translational initiation /// response to stress","translation initiation factor activity /// translation initiation factor activity /// translation initiation factor activity /// translation factor activity, nucleic acid binding","cytoplasm",null,1.3045,1,0,0,0.4454,0.3166]
[37,5,"208647_AT","FDFT1","farnesyl-diphosphate farnesyltransferase 1","Cholesterol_Biosynthesis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/metabolic_process-GenMAPP/Hs_Cholesterol_Biosynthesis/Hs_Cholesterol_Biosynthesis.htm","steroid biosynthetic process /// steroid biosynthetic process /// cholesterol biosynthetic process /// isoprenoid biosynthetic process /// lipid biosynthetic process /// biosynthetic process /// sterol biosynthetic process","magnesium ion binding /// catalytic activity /// farnesyl-diphosphate farnesyltransferase activity /// protein binding /// oxidoreductase activity /// transferase activity","endoplasmic reticulum /// membrane /// integral to membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",0.7841,-1,0,2,0.531,0.22]
[37,6,"212227_X_AT","EIF1","eukaryotic translation initiation factor 1","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation /// regulation of translational initiation /// response to stress","translation initiation factor activity /// translation initiation factor activity /// translation initiation factor activity /// translation factor activity, nucleic acid binding","cytoplasm",null,0.826,-1,0,0,0.3385,0.4577]
[37,7,"212130_X_AT","EIF1","eukaryotic translation initiation factor 1","Translation_Factors","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Translation_Factors/Hs_Translation_Factors.htm","translation /// translational initiation /// translational initiation /// regulation of translational initiation /// response to stress","translation initiation factor activity /// translation initiation factor activity /// translation initiation factor activity /// translation factor activity, nucleic acid binding","cytoplasm",null,1.3217,1,0,0,0.4653,0.2928]
[37,8,"209773_S_AT","RRM2","ribonucleotide reductase M2 polypeptide","---","---","DNA replication /// DNA replication /// deoxyribonucleoside diphosphate metabolic process /// deoxyribonucleotide metabolic process","ribonucleoside-diphosphate reductase activity /// ribonucleoside-diphosphate reductase activity /// iron ion binding /// protein binding /// oxidoreductase activity /// metal ion binding /// transition metal ion binding","cytoplasm /// cytoplasm","biosynthesis,metabolism,metabolic process,biosynthetic process:dna replication",0.3454,1,0,0,-0.0744,0.8741]
[]
[null,null,38]
[38,1,"213931_AT","ID2 /// ID2B","inhibitor of DNA binding 2, dominant negative helix-loop-helix protein /// inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein","---","---","striated muscle contraction /// multicellular organismal development /// multicellular organismal development /// heart development /// negative regulation of transcription /// negative regulation of transcription factor activity /// regulation of transcription","protein binding /// transcription repressor activity /// transcription regulator activity","nucleus /// nucleus /// cytoplasm","dna repair,transcription",3.9418,1,0,5,0.1243,0.7906]
[]
[null,null,39]
[39,1,"203747_AT","AQP3","aquaporin 3 (Gill blood group)","---","---","transport /// transport /// excretion","transporter activity /// transporter activity","membrane fraction /// integral to plasma membrane /// membrane /// integral to membrane","transport,ion channel",2.0187,1,0,-1,0.3084,0.501]
[39,2,"211410_X_AT","KIR2DL5A","killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A","---","---","---","receptor activity","---","unknown",4.7292,1,0,1,0.3033,0.5084]
[39,3,"215660_S_AT","MAST2","microtubule associated serine/threonine kinase 2","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// regulation of interleukin-12 biosynthetic process /// spermatid differentiation","nucleotide binding /// magnesium ion binding /// magnesium ion binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein binding /// protein binding /// ATP binding /// ATP binding /// kinase activity /// transferase activity /// phosphatase binding /// metal ion binding","cytoplasm /// cytoskeleton /// membrane","cell growth,differentiation:biosynthesis,metabolism,metabolic process,biosynthetic process",2.1558,1,0,-1,0.4578,0.3016]
[39,4,"221701_S_AT","STRA6","stimulated by retinoic acid gene 6 homolog (mouse)","---","---","---","---","protein complex","unknown",2.6974,1,0,3,-0.6688,0.1005]
[39,5,"207366_AT","KCNS1","potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1","---","---","transport /// ion transport /// potassium ion transport /// potassium ion transport","ion channel activity /// voltage-gated ion channel activity /// voltage-gated potassium channel activity /// delayed rectifier potassium channel activity /// potassium channel activity /// protein binding /// protein binding /// potassium channel regulator activity /// potassium channel regulator activity /// potassium ion binding","plasma membrane /// voltage-gated potassium channel complex /// voltage-gated potassium channel complex /// membrane /// integral to membrane","transport,ion channel",3.1941,1,0,-2,0.3151,0.4912]
[39,6,"219752_AT","RASAL1","RAS protein activator like 1 (GAP1 like)","---","---","signal transduction /// intracellular signaling cascade /// regulation of small GTPase mediated signal transduction","GTPase activator activity /// Ras GTPase activator activity /// phospholipid binding /// zinc ion binding /// metal ion binding","intracellular","signal transduction,signaling pathway",2.6483,1,0.4307,-2,0.2934,0.5231]
[39,7,"208633_S_AT","MACF1","microtubule-actin crosslinking factor 1","---","---","mesoderm formation /// carbohydrate metabolic process /// posttranslational protein targeting to membrane /// cell motility /// cell cycle arrest /// establishment and/or maintenance of cell polarity /// Wnt receptor signaling pathway","actin binding /// actin binding /// hydrolase activity, hydrolyzing O-glycosyl compounds /// calcium ion binding /// calcium ion binding /// protein binding /// protein binding /// microtubule binding /// microtubule binding /// actin filament binding","cytoplasm /// cytoplasm /// cytoplasm /// cytoskeleton /// cytoskeleton /// actin cytoskeleton /// microtubule cytoskeleton","biosynthesis,metabolism,metabolic process,biosynthetic process:cell cycle,proliferation:signal transduction,signaling pathway",2.0456,1,0,-1,0.4432,0.3192]
[39,8,"214957_AT","ACTL8","actin-like 8","---","---","---","structural molecule activity /// protein binding","cytoplasm /// cytoskeleton","unknown",5.0972,1,0,3,0.5065,0.2461]
[39,9,"218690_AT","PDLIM4","PDZ and LIM domain 4","---","---","---","protein binding /// protein binding /// zinc ion binding /// metal ion binding","---","unknown",1.5669,1,0.7074,-3,0.0219,0.9628]
[39,10,"207524_AT","ST7","suppression of tumorigenicity 7","---","---","---","---","---","unknown",2.8716,1,0,-1,0.2873,0.5322]
[39,11,"207669_AT","KRT83","keratin 83","---","---","epidermis development","structural molecule activity","intermediate filament",null,3.2388,1,0,-3,0.4425,0.3201]
[39,12,"216107_AT","---","PP13","---","---","---","---","---","unknown",5.4046,1,0,1,0.1368,0.7699]
[39,13,"218843_AT","FNDC4","fibronectin type III domain containing 4","---","---","---","---","membrane /// integral to membrane","unknown",2.6751,1,0,-1,0.2806,0.5422]
[39,14,"216356_X_AT","BAIAP3","BAI1-associated protein 3","---","---","neurotransmitter secretion","protein C-terminus binding","---",null,3.1903,1,0,-3,0.5166,0.2352]
[39,15,"206217_AT","EDA","ectodysplasin A","---","---","phosphate transport /// immune response /// signal transduction /// multicellular organismal development /// ectoderm development /// cell differentiation /// activation of NF-kappaB transcription factor","receptor binding /// receptor binding /// tumor necrosis factor receptor binding /// protein binding","membrane fraction /// cytoplasm /// cytoskeleton /// plasma membrane /// membrane /// integral to membrane /// integral to membrane","dna repair,transcription:cell growth,differentiation:transport,ion channel:immune response:signal transduction,signaling pathway",2.8346,1,0.4463,-3,0.2185,0.6379]
[39,16,"219897_AT","RNF122","ring finger protein 122","---","---","---","protein binding /// zinc ion binding /// metal ion binding","endoplasmic reticulum /// membrane /// integral to membrane","unknown",5.7629,1,0.0007,4,0.1292,0.7825]
[39,17,"221250_S_AT","MXD3","MAX dimerization protein 3","---","---","transcription /// regulation of transcription, DNA-dependent /// transport /// autophagy /// small GTPase mediated signal transduction /// protein transport /// regulation of transcription","nucleotide binding /// DNA binding /// protein binding /// GTP binding /// transcription regulator activity","nucleus /// endosome /// endoplasmic reticulum","dna repair,transcription:transport,ion channel:signal transduction,signaling pathway",3.1267,1,1.119,-1,-0.3171,0.4883]
[39,18,"217033_X_AT","NTRK3","neurotrophic tyrosine kinase, receptor, type 3","---","---","protein amino acid phosphorylation /// transmembrane receptor protein tyrosine kinase signaling pathway /// transmembrane receptor protein tyrosine kinase signaling pathway /// multicellular organismal development /// nervous system development /// cell differentiation","nucleotide binding /// protein kinase activity /// protein-tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// receptor activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// neurotrophin binding","integral to plasma membrane /// membrane /// integral to membrane","cell growth,differentiation:signal transduction,signaling pathway",2.7737,1,0.0006,1,0.3274,0.4735]
[39,19,"213204_AT","PARC","p53-associated parkin-like cytoplasmic protein","---","---","ubiquitin cycle /// cell cycle /// regulation of mitotic metaphase/anaphase transition","nucleotide binding /// protein binding /// ATP binding /// zinc ion binding /// metal ion binding","anaphase-promoting complex /// cytoplasm","cell cycle,proliferation",1.1296,1,0,1,0.1756,0.7064]
[39,20,"214903_AT","SYT2","synaptotagmin II","---","---","transport","transporter activity /// calcium ion binding /// metal ion binding","synaptic vesicle /// membrane /// integral to membrane /// cell junction /// cytoplasmic vesicle /// synapse","transport,ion channel",6.5629,1,0,0,0.264,0.5673]
[39,21,"205614_X_AT","MST1","macrophage stimulating 1 (hepatocyte growth factor-like)","---","---","proteolysis /// blood coagulation","serine-type endopeptidase activity /// calcium ion binding","---","proteolysis",0.7703,1,0.8399,-1,0.0296,0.9498]
[39,22,"206213_AT","WNT10B","wingless-type MMTV integration site family, member 10B","Wnt_signaling","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Wnt_signaling/Hs_Wnt_signaling.htm","signal transduction /// Wnt receptor signaling pathway, calcium modulating pathway /// multicellular organismal development /// Wnt receptor signaling pathway","signal transducer activity","extracellular region /// proteinaceous extracellular matrix","signal transduction,signaling pathway",6.1665,1,0,2,0.2502,0.5884]
[39,23,"209497_S_AT","RBM4B","RNA binding motif protein 4B","---","---","RNA processing /// mRNA processing /// RNA splicing /// type I hypersensitivity","nucleotide binding /// nucleic acid binding /// RNA binding /// RNA binding /// zinc ion binding /// metal ion binding","cytoplasm",null,2.8297,1,0,-1,0.4067,0.3652]
[39,24,"213288_AT","MBOAT2","membrane bound O-acyltransferase domain containing 2","---","---","---","acyltransferase activity /// transferase activity","membrane /// integral to membrane","unknown",2.6226,1,1.0886,2,-0.1771,0.704]
[39,25,"219103_AT","DDEFL1","development and differentiation enhancing factor-like 1","---","---","regulation of GTPase activity","zinc ion binding /// metal ion binding","cytoplasm",null,4.9036,1,0.1847,1,0.0992,0.8324]
[39,26,"211135_X_AT","LILRB3","leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3","---","---","defense response /// immune response /// cell surface receptor linked signal transduction","receptor activity /// receptor activity /// transmembrane receptor activity","integral to plasma membrane /// membrane /// integral to membrane","immune response:signal transduction,signaling pathway",5.4181,1,0,2,0.3641,0.422]
[39,27,"216320_X_AT","MST1","macrophage stimulating 1 (hepatocyte growth factor-like)","---","---","proteolysis /// blood coagulation","serine-type endopeptidase activity /// calcium ion binding","---","proteolysis",0.6562,1,0.916,-1,0.0215,0.9635]
[39,28,"37860_AT","ZNF337","zinc finger protein 337","---","---","transcription /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// zinc ion binding /// metal ion binding","intracellular","dna repair,transcription",2.7596,1,0,2,0.7851,0.0365]
[39,29,"205592_AT","IL8","interleukin 8","---","---","angiogenesis /// cell motility /// chemotaxis /// inflammatory response /// immune response /// cell cycle arrest /// G-protein coupled receptor protein signaling pathway /// intracellular signaling cascade /// cell-cell signaling /// negative regulation of cell proliferation /// calcium-mediated signaling /// regulation of cell adhesion /// neutrophil chemotaxis /// neutrophil activation /// regulation of retroviral genome replication /// induction of positive chemotaxis","interleukin-8 receptor binding /// protein binding /// chemokine activity","extracellular region /// extracellular space","cell adhesion:cell cycle,proliferation:immune response:signal transduction,signaling pathway",6.7191,1,0,1,0.2842,0.5367]
[39,30,"214950_AT","IL9R /// LOC729486","interleukin 9 receptor /// similar to Interleukin-9 receptor precursor (IL-9R) (CD129 antigen)","---","---","signal transduction /// cell proliferation","receptor activity /// hematopoietin/interferon-class (D200-domain) cytokine receptor activity /// interleukin-9 receptor activity","extracellular space /// integral to plasma membrane /// membrane /// integral to membrane","cell cycle,proliferation:signal transduction,signaling pathway",2.044,1,0,-1,0.5286,0.2225]
[39,31,"203760_S_AT","SLA","Src-like-adaptor","---","---","intracellular signaling cascade","SH3/SH2 adaptor activity","cytoplasm /// endosome",null,3.6823,1,0.5937,1,-0.15,0.7482]
[39,32,"215701_AT","---","EST from clone 51788, 5' end","---","---","---","---","---","unknown",7.1823,1,0.0003,1,0.3066,0.5036]
[39,33,"220232_AT","SCD5","stearoyl-CoA desaturase 5","---","---","lipid metabolic process /// fatty acid biosynthetic process /// lipid biosynthetic process","stearoyl-CoA 9-desaturase activity /// iron ion binding /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water","endoplasmic reticulum /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process",6.1542,1,0.5891,-1,0.1605,0.7311]
[39,34,"160020_AT","MMP14","matrix metallopeptidase 14 (membrane-inserted)","Matrix_Metalloproteinases","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/molecular_function_GenMAPP/Hs_Matrix_Metalloproteinases/Hs_Matrix_Metalloproteinases.htm","peptidoglycan metabolic process /// proteolysis /// proteolysis","metalloendopeptidase activity /// metalloendopeptidase activity /// calcium ion binding /// protein binding /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// zinc ion binding /// hydrolase activity /// metal ion binding","proteinaceous extracellular matrix /// integral to plasma membrane /// membrane /// integral to membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:proteolysis",5.7061,1,0.1464,1,0.2389,0.6059]
[39,35,"216981_X_AT","SPN","sialophorin (leukosialin, CD43)","---","---","response to protozoan /// negative regulation of type IV hypersensitivity /// chemotaxis /// immune response /// cellular defense response /// negative regulation of cell adhesion /// negative regulation of cell adhesion /// establishment and/or maintenance of cell polarity /// signal transduction /// cell surface receptor linked signal transduction /// induction of apoptosis by extracellular signals /// T cell costimulation /// positive regulation of T cell proliferation /// negative regulation of T cell proliferation /// positive regulation of tumor necrosis factor biosynthetic process /// positive regulation of tumor necrosis factor biosynthetic process /// defense response to bacterium /// defense response to bacterium /// negative thymic T cell selection /// regulation of antiviral response /// regulation of immune response /// negative regulation of T cell activation","transmembrane receptor activity /// binding /// protein binding /// bacterial binding /// bacterial binding","uropod /// basement membrane /// extracellular space /// integral to plasma membrane /// integral to plasma membrane /// external side of plasma membrane /// membrane /// integral to membrane","cell adhesion:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:cell cycle,proliferation:immune response:signal transduction,signaling pathway",7.666,1,0,1,0.4027,0.3703]
[39,36,"219471_AT","C13orf18","chromosome 13 open reading frame 18","---","---","regulation of signal transduction /// regulation of phosphoprotein phosphatase activity","protein phosphatase inhibitor activity","---","signal transduction,signaling pathway",2.2843,1,0.0008,1,-0.0764,0.8707]
[39,37,"222329_X_AT","---","---","---","---","mismatch repair","RNA binding /// ATP binding /// mismatched DNA binding","---",null,9.9633,1,0,-3,0.2589,0.575]
[39,38,"206057_X_AT","SPN","sialophorin (leukosialin, CD43)","---","---","response to protozoan /// negative regulation of type IV hypersensitivity /// chemotaxis /// immune response /// cellular defense response /// negative regulation of cell adhesion /// negative regulation of cell adhesion /// establishment and/or maintenance of cell polarity /// signal transduction /// cell surface receptor linked signal transduction /// induction of apoptosis by extracellular signals /// T cell costimulation /// positive regulation of T cell proliferation /// negative regulation of T cell proliferation /// positive regulation of tumor necrosis factor biosynthetic process /// positive regulation of tumor necrosis factor biosynthetic process /// defense response to bacterium /// defense response to bacterium /// negative thymic T cell selection /// regulation of antiviral response /// regulation of immune response /// negative regulation of T cell activation","transmembrane receptor activity /// binding /// protein binding /// bacterial binding /// bacterial binding","uropod /// basement membrane /// extracellular space /// integral to plasma membrane /// integral to plasma membrane /// external side of plasma membrane /// membrane /// integral to membrane","cell adhesion:biosynthesis,metabolism,metabolic process,biosynthetic process:apoptosis:cell cycle,proliferation:immune response:signal transduction,signaling pathway",6.9463,1,0.9454,1,0.3928,0.3834]
[39,39,"215887_AT","ZNF277P","zinc finger protein 277 pseudogene","---","---","transcription /// regulation of transcription, DNA-dependent /// regulation of transcription, DNA-dependent","nucleic acid binding /// DNA binding /// transcription factor activity /// receptor activity /// protein binding /// zinc ion binding /// metal ion binding","intracellular /// nucleus","dna repair,transcription",0.7541,1,0,1,0.0729,0.8766]
[39,40,"211004_S_AT","ALDH3B1","aldehyde dehydrogenase 3 family, member B1","---","---","alcohol metabolic process /// aldehyde metabolic process /// lipid metabolic process /// metabolic process","3-chloroallyl aldehyde dehydrogenase activity /// aldehyde dehydrogenase [NAD(P)+] activity /// oxidoreductase activity","---","biosynthesis,metabolism,metabolic process,biosynthetic process",5.1585,1,0,1,0.3213,0.4822]
[39,41,"214349_AT","---","Transcribed locus","---","---","---","---","---","unknown",0.982,1,1.4878,1,-0.0939,0.8413]
[39,42,"207169_X_AT","DDR1","discoidin domain receptor family, member 1","---","---","protein amino acid phosphorylation /// cell adhesion /// cell adhesion /// transmembrane receptor protein tyrosine kinase signaling pathway","nucleotide binding /// protein kinase activity /// protein-tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// transmembrane receptor protein tyrosine kinase activity /// receptor activity /// ATP binding /// kinase activity /// transferase activity","integral to plasma membrane /// membrane /// integral to membrane","cell adhesion:signal transduction,signaling pathway",1.1946,-1,1.3448,0,0.4795,0.2763]
[39,43,"212430_AT","RBM38","RNA binding motif protein 38","---","---","---","nucleotide binding /// nucleic acid binding /// RNA binding","---","unknown",3.6891,1,0,0,0.6352,0.1253]
[39,44,"205266_AT","LIF","leukemia inhibitory factor (cholinergic differentiation factor)","TGF_Beta_Signaling_Pathway","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_TGF_Beta_Signaling_Pathway/Hs_TGF_Beta_Signaling_Pathway.htm","immune response /// cell surface receptor linked signal transduction /// cell-cell signaling /// multicellular organismal development /// positive regulation of cell proliferation /// negative regulation of hormone secretion","cytokine activity /// leukemia inhibitory factor receptor binding /// oncostatin-M receptor binding /// growth factor activity","extracellular region /// extracellular space","cell cycle,proliferation:immune response:signal transduction,signaling pathway",1.5033,1,0.0655,0,0.5593,0.1917]
[39,45,"204401_AT","KCNN4","potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4","---","---","transport /// ion transport /// potassium ion transport /// potassium ion transport /// defense response /// positive regulation of protein secretion","ion channel activity /// voltage-gated potassium channel activity /// calmodulin binding /// calcium-activated potassium channel activity /// calcium-activated potassium channel activity","membrane fraction /// voltage-gated potassium channel complex /// voltage-gated potassium channel complex /// membrane /// integral to membrane","transport,ion channel",3.1529,1,0.0002,0,0.3392,0.4566]
[39,46,"208690_S_AT","PDLIM1","PDZ and LIM domain 1 (elfin)","---","---","response to oxidative stress /// regulation of transcription","transcription coactivator activity /// protein binding /// zinc ion binding /// metal ion binding","transcription factor complex /// cytoplasm /// cytoskeleton","dna repair,transcription",1.7723,1,1.7256,0,0.0842,0.8576]
[]
[null,null,40]
[40,1,"202181_AT","KIAA0247","KIAA0247","---","---","---","---","membrane /// integral to membrane","unknown",10.3766,1,0.0004,-4,0.8066,0.0284]
[40,2,"204781_S_AT","FAS","Fas (TNF receptor superfamily, member 6)","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","protein complex assembly /// apoptosis /// apoptosis /// anti-apoptosis /// induction of apoptosis /// immune response /// signal transduction /// signal transduction /// regulation of apoptosis","signal transducer activity /// receptor activity /// receptor activity /// receptor activity /// transmembrane receptor activity /// protein binding /// protein binding /// identical protein binding","soluble fraction /// cytosol /// membrane /// integral to membrane","apoptosis:immune response:signal transduction,signaling pathway",10.9055,1,0,-2,0.8428,0.0173]
[40,3,"202695_S_AT","STK17A","serine/threonine kinase 17a","---","---","protein amino acid phosphorylation /// protein amino acid phosphorylation /// apoptosis /// induction of apoptosis /// protein kinase cascade","nucleotide binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein serine/threonine kinase activity /// ATP binding /// ATP binding /// kinase activity /// transferase activity","nucleus","apoptosis",9.8886,1,0,-6,0.779,0.039]
[40,4,"204780_S_AT","FAS","Fas (TNF receptor superfamily, member 6)","Apoptosis /// Apoptosis_GenMAPP /// Apoptosis_KEGG","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_GenMAPP/Hs_Apoptosis_GenMAPP.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis_KEGG/Hs_Apoptosis_KEGG.htm","protein complex assembly /// apoptosis /// apoptosis /// anti-apoptosis /// induction of apoptosis /// immune response /// signal transduction /// signal transduction /// regulation of apoptosis","signal transducer activity /// receptor activity /// receptor activity /// receptor activity /// transmembrane receptor activity /// protein binding /// protein binding /// identical protein binding","soluble fraction /// cytosol /// membrane /// integral to membrane","apoptosis:immune response:signal transduction,signaling pathway",9.149,1,0,-4,0.8046,0.0291]
[40,5,"205780_AT","BIK","BCL2-interacting killer (apoptosis-inducing)","---","---","apoptosis /// induction of apoptosis /// induction of apoptosis /// apoptotic program /// regulation of apoptosis","protein binding","mitochondrial envelope /// membrane /// integral to membrane","apoptosis",5.2295,1,0,-4,0.7607,0.0471]
[40,6,"207813_S_AT","FDXR","ferredoxin reductase","---","---","generation of precursor metabolites and energy /// electron transport /// electron transport /// lipid metabolic process /// steroid biosynthetic process /// transport /// steroid metabolic process /// cholesterol metabolic process","ferredoxin-NADP+ reductase activity /// ferredoxin-NADP+ reductase activity /// oxidoreductase activity","mitochondrion /// mitochondrion /// mitochondrial inner membrane","biosynthesis,metabolism,metabolic process,biosynthetic process:transport,ion channel",4.4911,1,1.465,-4,0.6129,0.1434]
[40,7,"219628_AT","ZMAT3","zinc finger, matrin type 3","---","---","---","nucleic acid binding /// zinc ion binding","intracellular /// nucleus","unknown",4.1717,1,0,-4,0.7092,0.0743]
[40,8,"207426_S_AT","TNFSF4","tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)","---","---","immune response /// signal transduction /// cell-cell signaling /// positive regulation of cell proliferation","receptor binding /// cytokine activity /// tumor necrosis factor receptor binding","extracellular space /// integral to plasma membrane /// membrane /// integral to membrane","cell cycle,proliferation:immune response:signal transduction,signaling pathway",15.5373,1,0,-4,0.5871,0.1658]
[40,9,"203562_AT","FEZ1","fasciculation and elongation protein zeta 1 (zygin I)","---","---","cell adhesion /// nervous system development /// axon guidance","protein binding /// gamma-tubulin binding","cytoplasm /// centrosome /// membrane","cell adhesion",9.2591,1,0,-6,0.9458,0.0013]
[40,10,"218346_S_AT","SESN1","sestrin 1","---","---","response to DNA damage stimulus /// cell cycle arrest /// cell cycle arrest /// negative regulation of cell proliferation","---","nucleus /// nucleus","cell cycle,proliferation",4.0085,1,0.001,-4,0.7022,0.0786]
[40,11,"209295_AT","TNFRSF10B","tumor necrosis factor receptor superfamily, member 10b","Apoptosis /// Apoptosis /// Apoptosis","http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm /// http://www.genmapp.org/HTML_MAPPs/Human/Hs_Contributed_20051123/cellular_process-GenMAPP/Hs_Apoptosis/Hs_Apoptosis.htm","electron transport /// apoptosis /// apoptosis /// caspase activation /// signal transduction /// cell surface receptor linked signal transduction /// activation of NF-kappaB-inducing kinase /// induction of apoptosis via death domain receptors /// regulation of apoptosis /// positive regulation of I-kappaB kinase/NF-kappaB cascade","signal transducer activity /// receptor activity /// receptor activity /// protein binding /// protein binding /// caspase activator activity /// electron carrier activity /// TRAIL binding /// iron-sulfur cluster binding","membrane /// integral to membrane /// integral to membrane","transport,ion channel:apoptosis:signal transduction,signaling pathway",10.0865,1,0,-6,0.7169,0.0698]

{"sheet":"Note","index":1,"n_rows":4,"n_cols":1,"rows_kept":4,"flags":["formulas_cached_only"]}
["Note: "]
["Here we listed the 1312 most relevant response probes to ionizing radiation according to the Fisher's linear distriminant. "]
["These probes were further assigned to 40 clusters based on their expression profiles across all time points."]
["The detailed infomration of each probe (i.e. Gene title, GO information), nonlinear model estimation erros, gene regulation state, time delay effect, gene regulation state based on event method or correlation methods are presented too."]