Table S2. List of the human-specific splice donors reported in this study

No	Exon ID	Position (hg19)	Dir	Human donor	Chimp donor	Category	Usage	Gene symbol	Protein accession	mRNA accession	Gene title	Note
1	uc001cjm.2_6_7	chr1:43917099	-	GT	GC	(D4) shift; decrease; frameshift	alternative	HYI	NP_112484.3	NM_031207.5	putative hydroxypyruvate isomerase
2	uc001gdg.2_1_6	chr1:165601511	+	GT	AT	(D7) exonization; novel start	alternative	MGST3	Q5VV89	BG709310.1	microsomal glutathione S-transferase 3
3	uc010pkz.1_1_11	chr1:165667645	-	GT	GC	(D3) shift; decrease; inframe	alternative	ALDH9A1	B4DX14	AK293520.1	aldehyde dehydrogenase 9 family, member A1
4	uc010pxj.1_9_10	chr1:232144729	+	GT	GC	(D3) shift; decrease; inframe	alternative	DISC1	NP_001012975.1	NM_001012957.1	disrupted in schizophrenia 1 protein
5	uc010pyf.1_1_9	chr1:240408865	+	GT	AT	(D7) exonization; novel start	alternative	FMN2	B7Z4S3	AK297755.1	formin 2
6	uc002tif.2_1_7	chr2:113514470	-	GT	CT	(D8) intronization; inframe	alternative	CKAP2L	Q8IYA6-2	AK097948.1	cytoskeleton associated protein 2-like
7	uc010fqy.2_2_3	chr2:177054409	+	GT	GC	(D6) exonization; frameshift	alternative	HOXD1	B2RAB4	BC028190.1	homeobox D1	dbSNP:rs13390932
8	uc010zhi.1_1_13	chr2:201728824	-	GT	GC	(D7) exonization; novel start	alternative	CLK1	NP_001155879.1	NM_001162407.1	CDC-like kinase 1
9	uc002vmt.1_9_10	chr2:223066131	-	GT	AT	(D9) intronization; frameshift	alternative	PAX3	NP_852124.1	NM_181459.3	paired box 3
10	uc011axk.1_2_17	chr3:33118586	-	GT	AT	(D5) exonization; inframe	alternative	GLB1	B7Z6Q5	AK300753.1	galactosidase, beta 1
11	uc011bql.1_1_17	chr3:180633316	+	GT	GG	(D7) exonization; novel start	alternative	FXR1	B4DXZ6	AK302197.1	fragile X mental retardation, autosomal homolog 1
12	uc011cfo.1_2_11	chr4:109683977	-	GT	GA	(D2) shift; increase; frameshift	alternative	AGXT2L1	NP_001140099.1	NM_001146627.1	alanine-glyoxylate aminotransferase 2-like 1
13	uc003ldj.2_17_18	chr5:138268647	+	GT	GG	(D6) exonization; frameshift	alternative	CTNNA1	P35221-2	U03100.1	catenin (cadherin-associated protein), alpha 1, 102kDa
14	uc011dbw.1_12_13	chr5:146763517	+	GT	AT	(D4) shift; decrease; frameshift	alternative	STK32A	B7Z9H7	AK315942.1	serine/threonine-protein kinase 32A
15	uc003pne.3_14_15	chr6:90338942	+	GT	GC	(D3) shift; decrease; inframe	alternative	ANKRD6	NP_055757.3	NM_014942.4	ankyrin repeat domain-containing protein 6
16	uc011kma.1_7_8	chr7:107254177	+	GT	AT	(D6) exonization; frameshift	alternative	BCAP29	NP_001008405.1	NM_001008405.2	B-cell receptor-associated protein 29
17	uc003wii.2_2_10	chr7:150725998	+	GT	TT	(D5) exonization; inframe	alternative	ABCB8	Q6ZRM3	AK128129.1	ATP-binding cassette, sub-family B (MDR/TAP), member 8
18	uc003wjw.2_11_14	chr7:151071287	+	GT	GC	(D3) shift; decrease; inframe	alternative	NUB1	NP_057202.3	NM_016118.4	negative regulator of ubiquitin-like proteins 1
19	uc003ybd.2_5_9	chr8:79601608	+	GT	AT	(D1) shift; increase; inframe	constitutive	FAM164A	NP_057094.2	NM_016010.2	family with sequence similarity 164, member A	GTNGTN
20	uc003yil.1_11_12	chr8:99205613	-	GT	AT	(D6) exonization; frameshift	alternative	NIPAL2	NP_079035.1	NM_024759.1	NIPA-like domain containing 2	dbSNP:rs3735887
21	uc001ljt.2_45_52	chr10:129216805	+	GT	GC	(D10) type change (GC to GT)	constitutive	DOCK1	NP_001371.1	NM_001380.3	dedicator of cytokinesis 1	GC to GT
22	uc001lvx.1_6_7	chr11:2334938	+	GT	GC	(D4) shift; decrease; frameshift	alternative	TSPAN32	Q96QS1-3	AF176070.1	tetraspanin-32
23	uc009ywj.2_1_19	chr11:94225808	-	GT	AT	(D1) shift; increase; inframe	alternative	MRE11A	B3KTC7	AK095388.1	meiotic recombination 11 homolog A (S. cerevisiae)	dbSNP:rs496797
24	uc001qip.3_20_26	chr12:999676	+	GT	AT	(D3) shift; decrease; inframe	alternative	WNK1	NP_055638.2	NM_014823.2	serine/threonine-protein kinase WNK1	GTNGTN
25	uc001szm.1_1_16	chr12:81472207	+	GT	TT	(D3) shift; decrease; inframe	alternative	ACSS3	Q9H6R3	DA156034.1	acyl-CoA synthetase short-chain family member 3	GTNGTN
26	uc001wxi.1_1_3	chr14:50472312	-	GT	CT	(D7) exonization; novel start	constitutive	C14orf182	NP_001012724.1	NM_001012706.1	chromosome 14 open reading frame 182	de novo protein
27	uc010tyr.1_1_8	chr14:105939849	+	GT	GC	(D7) exonization; novel start	alternative	CRIP2	B7Z6C0	AK300092.1	cysteine-rich protein 2
28	uc010ujw.1_1_8	chr15:67841545	+	GT	TT	(D7) exonization; novel start	alternative	MAP2K5	NP_001193733.1	NM_001206804.1	mitogen-activated protein kinase kinase 5
29	uc002ayt.1_10_14	chr15:75114241	+	GT	GC	(D5) exonization; inframe	constitutive	LMAN1L	NP_068591.2	NM_021819.2	lectin, mannose-binding, 1 like
30	uc002fck.2_4_9	chr16:72863678	-	GT	GC	(D3) shift; decrease; inframe	constitutive	ZFHX3	NP_001158238.1	NM_001164766.1	zinc finger homeobox protein 3
31	uc010vqa.1_2_3	chr17:650785	-	GT	AT	(D9) intronization; frameshift	alternative	GEMIN4	B4DZ29	AK302722.1	gem (nuclear organelle) associated protein 4
32	uc002htp.2_2_5	chr17:38172107	+	GT	GC	(D1) shift; increase; inframe	alternative	CSF3	NP_000750.1	NM_000759.3	colony stimulating factor 3 (granulocyte)
33	uc002kms.1_1_6	chr18:5406764	-	GT	GC	(D1) shift; increase; inframe	alternative	EPB41L3	B3KT50	AK094952.1	erythrocyte membrane protein band 4.1-like 3
34	uc010dpa.2_1_7	chr18:48346267	-	GT	GG	(D7) exonization; novel start	alternative	MRO	NP_001120648.1	NM_001127176.1	maestro
35	uc010zuc.1_1_15	chr20:31619550	+	GT	GC	(D1) shift; increase; inframe	alternative	BPIFB6	NP_777557.1	NM_174897.2	BPI fold containing family B, member 6	GTNGTN