Over-representation analysis of bicluster 511-512 in Reactome. This file reports the list of statistically over-represented events in bicluster 511-512. False discovery rate Un-adjusted probability of seeing N or more genes in this Event by chance Number of genes in your query which map to this Event Total number of genes involved in this Event Identifier of this Event Name of this Event Submitted identifiers mapping to this Event - 1.24916635853632e-05 7 110 REACT_22232 Signaling by Interleukins SQSTM1, IL1RAP, UBC, MAP3K8, MAPK1, CRK, JAK1 - 0.000247759473097463 4 43 REACT_22442 Interleukin-1 signaling SQSTM1, IL1RAP, UBC, MAP3K8 - 0.000432568839967674 6 137 REACT_98011 Signaling by Interleukins SQSTM1, IL1RAP, MAP3K8, MAPK1, CRK, JAK1 - 0.000763520092326422 2 6 REACT_13601 Polyubiquitinated NRIF migrates to the nucleus SQSTM1, UBC - 0.000763520092326422 2 6 REACT_13460 Polyubiquitinated NRIF binds to p62 (Sequestosome) SQSTM1, UBC - 0.00106396310509438 2 7 REACT_25378 Ubiquitination of CRY Proteins UBC, CRY2 - 0.0018070443186819 2 9 REACT_13753 TRAF6 is auto-ubiquitinated SQSTM1, UBC - 0.0018070443186819 2 9 REACT_22099 Phosphorylation of L1 by ERK AP2B1, MAPK1 - 0.0018070443186819 2 9 REACT_111089 Ubiquitination of p130 (RBL2) by SCF (Skp2) UBC, RBL2 - 0.00250188882398815 6 192 REACT_11123 Membrane Trafficking SNX9, GBF1, UBC, TSG101, DAB2, GNS - 0.00255306272166774 3 38 REACT_821 Cyclin D associated events in G1 UBC, RBL2, RBL1 - 0.00255306272166774 3 38 REACT_1590 G1 Phase UBC, RBL2, RBL1 - 0.00273521775434487 2 11 REACT_115855 Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex UBC, TSG101 - 0.00326705217883577 2 12 REACT_115893 Membrane binding and targetting of GAG proteins UBC, TSG101 - 0.00326705217883577 2 12 REACT_120788 Destruction of Ubiquitinated HIF-alpha by the Proteasome UBC, HIF1A - 0.00326705217883577 2 12 REACT_121002 Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex UBC, HIF1A - 0.00339056016761357 4 86 REACT_1195 Insulin receptor signalling cascade GAB1, PDE3B, MAPK1, CRK - 0.00384317917052487 2 13 REACT_115860 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBC, TSG101 - 0.00384317917052487 2 13 REACT_6818 Assembly of HIV virion UBC, TSG101 - 0.00384317917052487 2 13 REACT_13415 p75NTR recruits signalling complexes SQSTM1, UBC - 0.00384317917052487 2 13 REACT_13696 NF-kB is activated and signals survival SQSTM1, UBC - 0.00384317917052487 2 13 REACT_27319 Cargo Sequestration UBC, TSG101 - 0.00384317917052487 2 13 REACT_27272 Cargo Recognition And Sorting UBC, TSG101 - 0.00446295279573138 2 14 REACT_118619 Ubiquitination of IkB by SCF-beta-TrCP UBC, FBXW11 - 0.00512573384301668 2 15 REACT_13643 NRIF signals cell death from the nucleus SQSTM1, UBC - 0.00512573384301668 2 15 REACT_120954 Cytosolic Ubiquitination of HIF-alpha UBC, HIF1A - 0.00512573384301668 2 15 REACT_121374 Nuclear Ubiquitination of HIF-alpha UBC, HIF1A - 0.0052722491065348 3 49 REACT_23837 Interleukin-3, 5 and GM-CSF signaling UBC, CRK, JAK1 - 0.00553319980414463 5 158 REACT_75901 Transfer of Ub from E2 to substrate and release of E2 RNF6, UBC, UBE3C, KLHL20, FBXW11 - 0.00553319980414463 5 158 REACT_75847 Polyubiquitination of substrate RNF6, UBC, UBE3C, KLHL20, FBXW11 - 0.00553319980414463 5 158 REACT_75856 Interaction of E3 with substrate and E2-Ub complex RNF6, UBC, UBE3C, KLHL20, FBXW11 - 0.00583088976273888 2 16 REACT_12002 ARMS-mediated activation MAPK1, CRK - 0.00583088976273888 2 16 REACT_13537 p75NTR signals via NF-kB SQSTM1, UBC - 0.00736582897083344 2 18 REACT_120916 Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha UBC, HIF1A - 0.00786248652396972 4 109 REACT_498 Signaling by Insulin receptor GAB1, PDE3B, MAPK1, CRK - 0.0081943799320155 2 19 REACT_115852 Signaling by constitutively active EGFR GAB1, UBC - 0.00906284099384295 2 20 REACT_12005 Prolonged ERK activation events MAPK1, CRK - 0.00969054362275792 3 61 REACT_11235 trans-Golgi Network Vesicle Budding SNX9, GBF1, GNS - 0.00969054362275792 3 61 REACT_19187 Clathrin derived vesicle budding SNX9, GBF1, GNS - 0.0108190761362332 7 340 REACT_75790 Cytokine Signaling in Immune system SQSTM1, IL1RAP, UBC, MAP3K8, MAPK1, CRK, JAK1 - 0.0109170992098633 2 22 REACT_23787 Regulation of signaling by CBL UBC, CRK - 0.0112679341999587 4 121 REACT_75928 Release of E3 from polyubiquitinated substrate RNF6, UBE3C, KLHL20, FBXW11 - 0.0139830129097569 2 25 REACT_20547 Metal ion SLC transporters SLC40A1, SLC41A1 - 0.0139830129097569 2 25 REACT_120815 Regulation of Hypoxia-inducible Factor (HIF) by Oxygen UBC, HIF1A - 0.0139830129097569 2 25 REACT_111214 G0 and Early G1 RBL2, RBL1 - 0.0139830129097569 2 25 REACT_121311 Cellular response to hypoxia UBC, HIF1A - 0.0139830129097569 2 25 REACT_120956 Cellular responses to stress UBC, HIF1A - 0.0150785506976883 2 26 REACT_12484 EGFR downregulation AP2B1, UBC - 0.0159786453782235 6 283 REACT_11061 Signalling by NGF SQSTM1, GAB1, AP2B1, UBC, MAPK1, CRK - 0.0162099281985126 2 27 REACT_15523 Integrin alphaIIb beta3 signaling RAPGEF4, CRK - 0.0173765882680003 2 28 REACT_27258 Endosomal Sorting Complex Required For Transport (ESCRT) UBC, TSG101 - 0.0179300261144797 5 211 REACT_75842 Antigen processing: Ubiquitination & Proteasome degradation RNF6, UBC, UBE3C, KLHL20, FBXW11 - 0.01944085582274 3 79 REACT_332 IRS-mediated signalling GAB1, PDE3B, MAPK1 - 0.0207647497063613 3 81 REACT_762 IRS-related events GAB1, PDE3B, MAPK1 - 0.0210827809243849 2 31 REACT_120734 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UBC, RBL1 - 0.0221373496387759 3 83 REACT_150203 IRS-related events triggered by IGF1R GAB1, PDE3B, MAPK1 - 0.0242876759554476 3 86 REACT_150359 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GAB1, PDE3B, MAPK1 - 0.0242876759554476 3 86 REACT_150210 IGF1R signaling cascade GAB1, PDE3B, MAPK1 - 0.0250870217357861 2 34 REACT_765 Mitotic Prophase MASTL, MAPK1 - 0.0250870217357861 2 34 REACT_22272 Signal transduction by L1 AP2B1, MAPK1 - 0.0264855503098014 2 35 REACT_24941 Circadian Clock UBC, CRY2 - 0.0293752039145644 2 37 REACT_278 Platelet Aggregation (Plug Formation) RAPGEF4, CRK - 0.0293752039145644 2 37 REACT_12058 Signalling to ERKs MAPK1, CRK - 0.033933670483978 2 40 REACT_111184 Negative regulation of FGFR signaling UBC, MAPK1 - 0.0355109253292621 2 41 REACT_22365 Recycling pathway of L1 AP2B1, MAPK1 - 0.0363567932655377 4 173 REACT_9417 Signaling by EGFR GAB1, AP2B1, UBC, MAPK1 - 0.0371162604475287 2 42 REACT_22237 Netrin-1 signaling NTN4, RGMB - 0.0371162604475287 2 42 REACT_27283 Interleukin-2 signaling MAPK1, JAK1 - 0.0376856393491187 4 175 REACT_115871 Signaling by EGFR in Cancer GAB1, AP2B1, UBC, MAPK1 - 0.0438090048387802 2 46 REACT_121061 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer UBC, RBL1 - 0.045547736851376 2 47 REACT_118780 NOTCH1 Intracellular Domain Regulates Transcription UBC, HIF1A - 0.0459913408178867 6 362 REACT_91328 Cytokine Signaling in Immune system SQSTM1, IL1RAP, MAP3K8, MAPK1, CRK, JAK1 - 0.0495771184558632 5 277 REACT_18266 Axon guidance AP2B1, NTN4, RGMB, ST8SIA2, MAPK1