Supplementary Table I: The p-value distribution of sequence pairs in GO groups of molecular function ontology GO ID "(E-2, 1]" "(E-5, E-2]" "(E-10, E-5]" "(E-20, E-10]" "(E-50, E-20]" "(E-100, E-50]" "[0, -100]" Description GO_0003674(3317) 96.03 3.46 0.32 0.1 0.06 0.02 0.01 molecular_function * GO_0045182(55) 93.13 3.5 1.62 0.74 0.4 0.2 0.4 translation regulator activity * * GO_0008135(44) 91.12 3.81 2.33 1.16 0.63 0.32 0.63 "translation factor activity, nucleic acid binding" * * * GO_0003746(9) 69.44 0 5.56 11.11 8.33 0 5.56 translation elongation factor activity * * * GO_0003743(30) 93.1 4.14 0.69 0.92 0.23 0.23 0.69 translation initiation factor activity * GO_0030528(311) 86.96 9.55 2.42 0.71 0.28 0.03 0.04 transcription regulator activity * * GO_0016564(24) 76.45 14.86 5.43 2.54 0.72 0 0 transcriptional repressor activity * * * GO_0016566(10) 68.89 22.22 6.67 2.22 0 0 0 specific transcriptional repressor activity * * GO_0003712(30) 91.72 6.44 0.92 0 0.23 0.46 0.23 transcription cofactor activity * * * GO_0003713(9) 88.89 5.56 5.56 0 0 0 0 transcription coactivator activity * * * GO_0003714(13) 88.46 6.41 0 0 1.28 2.56 1.28 transcription corepressor activity * * GO_0003711(20) 85.26 12.63 2.11 0 0 0 0 transcriptional elongation regulator activity * * * GO_0016944(17) 86.76 13.24 0 0 0 0 0 RNA polymerase II transcription elongation factor activity * * GO_0003702(116) 88.14 8.94 2.07 0.54 0.25 0.03 0.03 RNA polymerase II transcription factor activity * * * GO_0016251(61) 91.09 7.32 1.2 0.33 0.05 0 0 general RNA polymerase II transcription factor activity * * * * GO_0016455(20) 89.47 8.95 1.05 0.53 0 0 0 RNA polymerase II transcription mediator activity * * * GO_0003704(40) 75.38 15.51 5.64 1.79 1.28 0.26 0.13 specific RNA polymerase II transcription factor activity * * GO_0003701(10) 97.78 2.22 0 0 0 0 0 RNA polymerase I transcription factor activity * * GO_0016563(33) 74.43 17.23 5.68 1.33 0.57 0.19 0.57 transcriptional activator activity * * GO_0003709(10) 97.78 2.22 0 0 0 0 0 RNA polymerase III transcription factor activity * * GO_0003700(63) 77.88 14.13 4.81 1.74 0.97 0.26 0.2 transcription factor activity * GO_0030234(137) 91.54 6.77 0.99 0.41 0.16 0.05 0.08 enzyme regulator activity * * GO_0030695(58) 87.42 8.59 1.69 1.39 0.6 0 0.3 GTPase regulator activity * * * GO_0005096(29) 80.54 8.87 5.17 3.45 1.48 0 0.49 GTPase activator activity * * * * GO_0005097(7) 23.81 14.29 23.81 19.05 14.29 0 4.76 Rab GTPase activator activity * * * * GO_0005100(7) 9.52 14.29 47.62 23.81 4.76 0 0 Rho GTPase activator activity * * * GO_0005083(51) 86.27 8.86 1.88 1.8 0.78 0 0.39 small GTPase regulator activity * * * * GO_0005085(23) 86.96 6.72 0.79 3.16 1.19 0 1.19 guanyl-nucleotide exchange factor activity * * * * * GO_0005086(6) 53.33 0 0 20 20 0 6.67 ARF guanyl-nucleotide exchange factor activity * * * * GO_0005097(7) 23.81 14.29 23.81 19.05 14.29 0 4.76 Rab GTPase activator activity * * * * GO_0005100(7) 9.52 14.29 47.62 23.81 4.76 0 0 Rho GTPase activator activity * * GO_0019208(11) 83.64 7.27 3.64 1.82 1.82 0 1.82 phosphatase regulator activity * * * GO_0019888(11) 83.64 7.27 3.64 1.82 1.82 0 1.82 protein phosphatase regulator activity * * GO_0019207(31) 86.02 8.17 2.8 1.51 0.65 0.65 0.22 kinase regulator activity * * * GO_0019887(28) 84.66 8.47 3.44 1.85 0.53 0.79 0.26 protein kinase regulator activity * * * * GO_0004860(6) 93.33 0 0 0 0 0 6.67 protein kinase inhibitor activity * * * * GO_0016538(15) 59.05 17.14 12.38 6.67 1.9 2.86 0 cyclin-dependent protein kinase regulator activity * * * GO_0019210(7) 95.24 0 0 0 0 0 4.76 kinase inhibitor activity * * * * GO_0004860(6) 93.33 0 0 0 0 0 6.67 protein kinase inhibitor activity * * * GO_0019209(6) 100 0 0 0 0 0 0 kinase activator activity * * GO_0008047(53) 88.03 7.98 2.03 1.16 0.51 0.15 0.15 enzyme activator activity * * * GO_0005096(29) 80.54 8.87 5.17 3.45 1.48 0 0.49 GTPase activator activity * * * * GO_0005097(7) 23.81 14.29 23.81 19.05 14.29 0 4.76 Rab GTPase activator activity * * * * GO_0005100(7) 9.52 14.29 47.62 23.81 4.76 0 0 Rho GTPase activator activity * * * GO_0019209(6) 100 0 0 0 0 0 0 kinase activator activity * * GO_0004857(18) 94.12 2.61 1.96 0 0 0 1.31 enzyme inhibitor activity * * * GO_0019210(7) 95.24 0 0 0 0 0 4.76 kinase inhibitor activity * * * * GO_0004860(6) 93.33 0 0 0 0 0 6.67 protein kinase inhibitor activity * GO_0016209(18) 86.93 5.23 0.65 0.65 3.92 0.65 1.96 antioxidant activity * * GO_0004601(14) 85.71 5.49 0 1.1 4.4 1.1 2.2 peroxidase activity * GO_0005488(998) 93.32 5.56 0.77 0.2 0.09 0.03 0.02 binding * * GO_0048037(10) 93.33 2.22 2.22 0 0 0 2.22 cofactor binding * * * GO_0050662(7) 95.24 0 4.76 0 0 0 0 coenzyme binding * * GO_0043167(60) 91.36 5.42 2.15 0.51 0.28 0.06 0.23 ion binding * * * GO_0046872(60) 91.36 5.42 2.15 0.51 0.28 0.06 0.23 metal ion binding * * * * GO_0046914(44) 87.1 7.93 3.38 0.74 0.53 0 0.32 transition metal ion binding * * * * * GO_0008270(36) 81.9 10.79 5.08 0.95 0.79 0 0.48 zinc ion binding * * * * * GO_0005507(6) 80 13.33 0 6.67 0 0 0 copper ion binding * * * * GO_0005509(7) 71.43 9.52 9.52 0 0 4.76 4.76 calcium ion binding * * * GO_0043169(50) 88.65 7.18 2.78 0.57 0.41 0.08 0.33 cation binding * * * * GO_0046914(44) 87.1 7.93 3.38 0.74 0.53 0 0.32 transition metal ion binding * * * * * GO_0008270(36) 81.9 10.79 5.08 0.95 0.79 0 0.48 zinc ion binding * * * * * GO_0005507(6) 80 13.33 0 6.67 0 0 0 copper ion binding * * * * GO_0005509(7) 71.43 9.52 9.52 0 0 4.76 4.76 calcium ion binding * * GO_0042277(14) 95.6 4.4 0 0 0 0 0 peptide binding * * * GO_0005048(14) 95.6 4.4 0 0 0 0 0 signal sequence binding * * GO_0008289(18) 81.05 11.11 0.65 0.65 1.96 3.27 1.31 lipid binding * * * GO_0005543(14) 78.02 10.99 0 1.1 3.3 5.49 1.1 phospholipid binding * * * * GO_0035091(11) 70.91 10.91 0 1.82 5.45 9.09 1.82 phosphoinositide binding * * GO_0005515(385) 92.03 6.65 0.93 0.19 0.1 0.07 0.03 protein binding * * * GO_0019899(8) 89.29 10.71 0 0 0 0 0 enzyme binding * * * * GO_0051020(6) 100 0 0 0 0 0 0 GTPase binding * * * * * GO_0031267(6) 100 0 0 0 0 0 0 small GTPase binding * * * GO_0008134(34) 91.44 6.77 0.89 0.18 0.18 0.36 0.18 transcription factor binding * * * * GO_0003712(30) 91.72 6.44 0.92 0 0.23 0.46 0.23 transcription cofactor activity * * * * * GO_0003713(9) 88.89 5.56 5.56 0 0 0 0 transcription coactivator activity * * * * * GO_0003714(13) 88.46 6.41 0 0 1.28 2.56 1.28 transcription corepressor activity * * * GO_0008092(50) 84.82 10.94 3.02 0.49 0.49 0.16 0.08 cytoskeletal protein binding * * * * GO_0015631(16) 76.67 19.17 3.33 0 0.83 0 0 tubulin binding * * * * * GO_0008017(7) 71.43 19.05 9.52 0 0 0 0 microtubule binding * * * * GO_0003779(17) 92.65 3.68 1.47 0.74 0.74 0.74 0 actin binding * * * * * GO_0051015(8) 78.57 10.71 3.57 3.57 3.57 0 0 actin filament binding * * * GO_0030276(9) 75 8.33 5.56 5.56 0 0 5.56 clathrin binding * * * GO_0051082(54) 89.73 4.4 1.05 0.42 1.19 2.52 0.7 unfolded protein binding * * * GO_0051087(7) 85.71 4.76 4.76 0 4.76 0 0 chaperone binding * * * GO_0008320(11) 67.27 10.91 10.91 5.45 1.82 3.64 0 protein carrier activity * * * GO_0005102(7) 85.71 4.76 0 4.76 4.76 0 0 receptor binding * * * GO_0030674(13) 88.46 8.97 0 1.28 1.28 0 0 "protein binding, bridging" * * GO_0003676(482) 92.2 6.14 1.1 0.31 0.17 0.04 0.04 nucleic acid binding * * * GO_0008135(44) 91.12 3.81 2.33 1.16 0.63 0.32 0.63 "translation factor activity, nucleic acid binding" * * * * GO_0003746(9) 69.44 0 5.56 11.11 8.33 0 5.56 translation elongation factor activity * * * * GO_0003743(30) 93.1 4.14 0.69 0.92 0.23 0.23 0.69 translation initiation factor activity * * * GO_0003723(204) 91.64 6.17 1.23 0.5 0.28 0.09 0.08 RNA binding * * * * GO_0019843(11) 67.27 18.18 9.09 1.82 1.82 0 1.82 rRNA binding * * * * GO_0030515(28) 75.4 10.85 5.82 3.44 3.7 0.79 0 snoRNA binding * * * * GO_0003729(26) 85.85 9.85 1.85 1.23 0.92 0.31 0 mRNA binding * * * * GO_0031202(40) 90.9 6.41 0.9 0.13 0.77 0.13 0.77 "RNA splicing factor activity, transesterification mechanism" * * * GO_0003677(218) 89.07 8.04 1.92 0.51 0.3 0.1 0.06 DNA binding * * * * GO_0008301(7) 71.43 19.05 4.76 0 4.76 0 0 DNA bending activity * * * * GO_0003684(10) 84.44 8.89 4.44 0 0 2.22 0 damaged DNA binding * * * * GO_0003689(6) 6.67 40 13.33 0 20 20 0 DNA clamp loader activity * * * * GO_0019237(6) 93.33 6.67 0 0 0 0 0 centromeric DNA binding * * * * GO_0003916(6) 66.67 20 0 0 0 0 13.33 DNA topoisomerase activity * * * * GO_0003697(12) 84.85 12.12 0 1.52 1.52 0 0 single-stranded DNA binding * * * * GO_0003688(7) 80.95 19.05 0 0 0 0 0 DNA replication origin binding * * * * GO_0000182(6) 93.33 6.67 0 0 0 0 0 ribosomal DNA * * * * GO_0042162(6) 86.67 13.33 0 0 0 0 0 telomeric DNA binding * * * * GO_0003700(63) 77.88 14.13 4.81 1.74 0.97 0.26 0.2 transcription factor activity * * * * GO_0003690(9) 69.44 2.78 8.33 11.11 5.56 2.78 0 double-stranded DNA binding * * GO_0000166(65) 92.21 4.42 1.2 1.11 0.72 0.1 0.24 nucleotide binding * * * GO_0017076(64) 91.96 4.56 1.24 1.14 0.74 0.1 0.25 purine nucleotide binding * * * * GO_0030554(52) 92.01 3.47 1.51 1.51 1.06 0.08 0.38 adenyl nucleotide binding * * * * * GO_0005524(50) 91.67 3.43 1.63 1.63 1.14 0.08 0.41 ATP binding * * * * GO_0019001(13) 76.92 12.82 3.85 3.85 1.28 1.28 0 guanyl nucleotide binding * * * * * GO_0005525(12) 80.3 10.61 4.55 3.03 0 1.52 0 GTP binding * * GO_0003682(20) 84.21 6.32 1.05 0 0.53 7.89 0 chromatin binding * * GO_0030246(6) 86.67 0 0 0 0 0 13.33 carbohydrate binding * * GO_0043021(6) 60 26.67 6.67 0 0 0 6.67 ribonucleoprotein binding * GO_0005215(392) 94.13 3.68 0.66 0.42 0.52 0.26 0.33 transporter activity * * GO_0042626(43) 85.6 2.1 2.21 4.1 2.21 1.99 1.77 "ATPase activity, coupled to transmembrane movement of substances" * * * GO_0042625(30) 85.75 1.84 1.61 3.68 3.91 2.07 1.15 "ATPase activity, coupled to transmembrane movement of ions" * * * * GO_0019829(19) 92.4 2.92 0 1.75 1.75 0 1.17 cation-transporting ATPase activity * * * * * GO_0046961(18) 92.16 2.61 0 1.96 1.96 0 1.31 "hydrogen-transporting ATPase activity, rotational mechanism" * * * * GO_0015662(12) 30.3 0 10.61 19.7 21.21 13.64 4.55 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" * * GO_0015267(11) 87.27 3.64 1.82 0 0 1.82 5.45 channel or pore class transporter activity * * * GO_0015268(9) 88.89 5.56 2.78 0 0 2.78 0 alpha-type channel activity * * * * GO_0005216(7) 85.71 4.76 4.76 0 0 4.76 0 ion channel activity * * GO_0015238(14) 41.76 10.99 15.38 12.09 10.99 1.1 7.69 drug transporter activity * * * GO_0015239(11) 47.27 9.09 14.55 9.09 12.73 0 7.27 multidrug transporter activity * * GO_0015144(27) 21.08 1.71 3.13 8.55 23.65 5.7 36.18 carbohydrate transporter activity * * * GO_0051119(24) 0.36 1.81 3.62 10.87 30.07 7.25 46.01 sugar transporter activity * * * * GO_0015145(17) 0 0 0 0 0 11.03 88.97 monosaccharide transporter activity * * * * * GO_0015149(17) 0 0 0 0 0 11.03 88.97 hexose transporter activity * * * * * * GO_0005354(6) 0 0 0 0 0 33.33 66.67 galactose transporter activity * * * * * * GO_0015578(15) 0 0 0 0 0 0 100 mannose transporter activity * * * * * * GO_0005353(15) 0 0 0 0 0 0 100 fructose transporter activity * * * * * * GO_0005355(16) 0 0 0 0 0 0 100 glucose transporter activity * * GO_0015075(140) 95.6 3.02 0.16 0.29 0.37 0.2 0.36 ion transporter activity * * * GO_0046873(38) 91.18 4.98 0.14 0.28 0.71 1.28 1.42 metal ion transporter activity * * * * GO_0046915(29) 88.67 6.9 0.25 0.25 0.49 1.48 1.97 transition metal ion transporter activity * * * * * GO_0005375(8) 82.14 10.71 0 3.57 0 3.57 0 copper ion transporter activity * * * * * GO_0005381(10) 75.56 6.67 0 0 0 8.89 8.89 iron ion transporter activity * * * GO_0042625(30) 85.75 1.84 1.61 3.68 3.91 2.07 1.15 "ATPase activity, coupled to transmembrane movement of ions" * * * * GO_0019829(19) 92.4 2.92 0 1.75 1.75 0 1.17 cation-transporting ATPase activity * * * * * GO_0046961(18) 92.16 2.61 0 1.96 1.96 0 1.31 "hydrogen-transporting ATPase activity, rotational mechanism" * * * * GO_0015662(12) 30.3 0 10.61 19.7 21.21 13.64 4.55 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" * * * GO_0008509(19) 91.23 2.92 0.58 1.17 0.58 1.17 2.34 anion transporter activity * * * * GO_0015103(13) 87.18 3.85 0 2.56 0 1.28 5.13 inorganic anion transporter activity * * * * * GO_0015114(8) 82.14 3.57 0 0 0 3.57 10.71 phosphate transporter activity * * * GO_0008324(120) 95.48 2.97 0.21 0.31 0.39 0.22 0.42 cation transporter activity * * * * GO_0019829(19) 92.4 2.92 0 1.75 1.75 0 1.17 cation-transporting ATPase activity * * * * * GO_0046961(18) 92.16 2.61 0 1.96 1.96 0 1.31 "hydrogen-transporting ATPase activity, rotational mechanism" * * * * GO_0015082(35) 91.09 5.04 0.17 0.34 0.5 1.34 1.51 "di-, tri-valent inorganic cation transporter activity" * * * * * GO_0005375(8) 82.14 10.71 0 3.57 0 3.57 0 copper ion transporter activity * * * * * GO_0005381(10) 75.56 6.67 0 0 0 8.89 8.89 iron ion transporter activity * * * * GO_0015077(62) 96.35 2.17 0.11 0.26 0.58 0.05 0.48 monovalent inorganic cation transporter activity * * * * * GO_0015078(59) 96.26 2.16 0.12 0.29 0.64 0.06 0.47 hydrogen ion transporter activity * * * * * * GO_0008121(9) 94.44 2.78 2.78 0 0 0 0 ubiquinol-cytochrome-c reductase activity * * * * * * GO_0046933(19) 90.64 4.68 0 1.17 1.75 0 1.75 "hydrogen-transporting ATP synthase activity, rotational mechanism" * * * * * * GO_0004129(13) 96.15 1.28 0 0 0 1.28 1.28 cytochrome-c oxidase activity * * * * * * GO_0046961(18) 92.16 2.61 0 1.96 1.96 0 1.31 "hydrogen-transporting ATPase activity, rotational mechanism" * * * * GO_0015662(12) 30.3 0 10.61 19.7 21.21 13.64 4.55 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" * * * GO_0005216(7) 85.71 4.76 4.76 0 0 4.76 0 ion channel activity * * GO_0008565(53) 94.05 3.41 1.31 0.73 0.15 0.22 0.15 protein transporter activity * * * GO_0008320(11) 67.27 10.91 10.91 5.45 1.82 3.64 0 protein carrier activity * * GO_0005478(30) 77.01 15.17 4.83 2.07 0.46 0 0.46 intracellular transporter activity * * * GO_0005484(24) 69.57 18.84 7.25 3.26 0.72 0 0.36 SNAP receptor activity * * * * GO_0005485(14) 74.73 15.38 6.59 2.2 1.1 0 0 v-SNARE activity * * * * GO_0005486(10) 17.78 37.78 26.67 13.33 2.22 0 2.22 t-SNARE activity * * GO_0005386(108) 94.57 2.98 0.47 0.57 0.66 0.52 0.24 carrier activity * * * GO_0015399(54) 93.92 2.03 0.63 1.12 1.19 0.7 0.42 primary active transporter activity * * * * GO_0015405(32) 86.9 2.22 1.41 3.23 3.43 1.81 1.01 P-P-bond-hydrolysis-driven transporter activity * * * * * GO_0015662(12) 30.3 0 10.61 19.7 21.21 13.64 4.55 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" * * * * * GO_0046961(18) 92.16 2.61 0 1.96 1.96 0 1.31 "hydrogen-transporting ATPase activity, rotational mechanism" * * * * GO_0008121(9) 94.44 2.78 2.78 0 0 0 0 ubiquinol-cytochrome-c reductase activity * * * * GO_0004129(13) 96.15 1.28 0 0 0 1.28 1.28 cytochrome-c oxidase activity * * * GO_0015290(36) 80.95 7.94 1.75 2.22 3.17 2.7 1.27 electrochemical potential-driven transporter activity * * * * GO_0015291(36) 80.95 7.94 1.75 2.22 3.17 2.7 1.27 porter activity * * * * * GO_0005279(12) 51.52 13.64 0 1.52 3.03 22.73 7.58 amino acid-polyamine transporter activity * * * * * * GO_0015359(7) 52.38 9.52 0 4.76 4.76 23.81 4.76 amino acid permease activity * * * * * GO_0015297(8) 75 3.57 0 7.14 10.71 0 3.57 antiporter activity * * * GO_0008320(11) 67.27 10.91 10.91 5.45 1.82 3.64 0 protein carrier activity * * GO_0005342(46) 70.92 8.12 1.55 1.45 3 10.05 4.93 organic acid transporter activity * * * GO_0046943(43) 69.66 8.31 1.66 1 2.55 11.3 5.54 carboxylic acid transporter activity * * * * GO_0015171(32) 54.64 9.88 2.62 1.01 2.22 20.16 9.48 amino acid transporter activity * * * * * GO_0005279(12) 51.52 13.64 0 1.52 3.03 22.73 7.58 amino acid-polyamine transporter activity * * * * * * GO_0015359(7) 52.38 9.52 0 4.76 4.76 23.81 4.76 amino acid permease activity * * * * * GO_0015174(8) 64.29 7.14 0 3.57 3.57 10.71 10.71 basic amino acid transporter activity * * * * * GO_0015175(8) 39.29 28.57 0 7.14 0 10.71 14.29 neutral amino acid transporter activity * * * * * GO_0015179(10) 44.44 11.11 6.67 0 2.22 22.22 13.33 L-amino acid transporter activity * * * * GO_0008028(8) 82.14 7.14 0 0 0 0 10.71 monocarboxylic acid transporter activity * * GO_0005319(10) 71.11 6.67 8.89 11.11 0 2.22 0 lipid transporter activity * * * GO_0005548(7) 42.86 9.52 19.05 23.81 0 4.76 0 phospholipid transporter activity * * GO_0005275(41) 62.2 11.71 4.02 1.22 2.07 12.8 5.98 amine transporter activity * * * GO_0015203(19) 57.31 17.54 2.34 1.17 2.92 14.62 4.09 polyamine transporter activity * * * * GO_0005279(12) 51.52 13.64 0 1.52 3.03 22.73 7.58 amino acid-polyamine transporter activity * * * * * GO_0015359(7) 52.38 9.52 0 4.76 4.76 23.81 4.76 amino acid permease activity * * * GO_0015171(32) 54.64 9.88 2.62 1.01 2.22 20.16 9.48 amino acid transporter activity * * * * GO_0005279(12) 51.52 13.64 0 1.52 3.03 22.73 7.58 amino acid-polyamine transporter activity * * * * * GO_0015359(7) 52.38 9.52 0 4.76 4.76 23.81 4.76 amino acid permease activity * * * * GO_0015175(8) 39.29 28.57 0 7.14 0 10.71 14.29 neutral amino acid transporter activity * * * * GO_0015179(10) 44.44 11.11 6.67 0 2.22 22.22 13.33 L-amino acid transporter activity * * * * GO_0015174(8) 64.29 7.14 0 3.57 3.57 10.71 10.71 basic amino acid transporter activity * * GO_0015932(8) 64.29 10.71 10.71 0 0 0 14.29 "nucleobase, nucleoside, nucleotide and nucleic acid transporter activity" * * GO_0051184(9) 77.78 2.78 0 8.33 5.56 5.56 0 cofactor transporter activity * * GO_0005489(23) 88.93 6.72 0.79 0.4 1.98 0.4 0.79 electron transporter activity * GO_0005198(302) 95.95 3.17 0.44 0.15 0.15 0.11 0.04 structural molecule activity * * GO_0003735(186) 97.99 1.71 0.05 0.04 0.03 0.12 0.06 structural constituent of ribosome * * GO_0005199(10) 62.22 2.22 6.67 8.89 13.33 6.67 0 structural constituent of cell wall * * GO_0005200(49) 78.83 11.48 4.34 1.53 2.3 1.45 0.09 structural constituent of cytoskeleton * GO_0004871(60) 87.12 6.5 1.86 2.49 1.47 0.28 0.28 signal transducer activity * * GO_0005057(12) 42.42 3.03 1.52 22.73 24.24 4.55 1.52 receptor signaling protein activity * * * GO_0004702(8) 0 0 0 42.86 42.86 10.71 3.57 receptor signaling protein serine/threonine kinase activity * * GO_0004872(20) 81.58 8.42 5.26 1.58 2.11 0.53 0.53 receptor activity * * * GO_0004888(13) 79.49 5.13 6.41 3.85 3.85 1.28 0 transmembrane receptor activity * * GO_0005102(7) 85.71 4.76 0 4.76 4.76 0 0 receptor binding * GO_0003824(1614) 96.72 2.77 0.17 0.15 0.14 0.03 0.03 catalytic activity * * GO_0016874(126) 94.18 4.13 0.66 0.36 0.24 0.2 0.23 ligase activity * * * GO_0016886(37) 86.64 6.76 2.25 2.55 0.9 0.3 0.6 "ligase activity, forming phosphoric ester bonds" * * * * GO_0008452(35) 85.55 7.23 2.52 2.86 0.84 0.34 0.67 RNA ligase activity * * * * * GO_0004812(34) 85.2 7.13 2.67 3.03 0.89 0.36 0.71 tRNA ligase activity * * * GO_0016879(75) 92.07 5.66 1.12 0.25 0.47 0.14 0.29 "ligase activity, forming carbon-nitrogen bonds" * * * * GO_0016881(53) 87.16 9.07 2.1 0.29 0.94 0.22 0.22 acid-amino acid ligase activity * * * * * GO_0004842(44) 84.57 10.36 2.85 0.42 1.27 0.32 0.21 ubiquitin-protein ligase activity * * * * GO_0016884(9) 83.33 0 5.56 2.78 0 0 8.33 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor" * * * GO_0016875(34) 85.2 7.13 2.67 3.03 0.89 0.36 0.71 "ligase activity, forming carbon-oxygen bonds" * * * * GO_0016876(34) 85.2 7.13 2.67 3.03 0.89 0.36 0.71 "ligase activity, forming aminoacyl-tRNA and related compounds" * * * * * GO_0004812(34) 85.2 7.13 2.67 3.03 0.89 0.36 0.71 tRNA ligase activity * * * GO_0016877(9) 38.89 27.78 11.11 2.78 0 8.33 11.11 "ligase activity, forming carbon-sulfur bonds" * * GO_0016853(43) 92.36 3.21 1.11 0.66 1.55 0.44 0.66 isomerase activity * * * GO_0016860(13) 83.33 2.56 6.41 2.56 2.56 1.28 1.28 intramolecular oxidoreductase activity * * * * GO_0016861(6) 93.33 6.67 0 0 0 0 0 "intramolecular oxidoreductase activity, interconverting aldoses and ketoses" * * * GO_0016859(10) 53.33 0 4.44 6.67 26.67 6.67 2.22 cis-trans isomerase activity * * * * GO_0003755(10) 53.33 0 4.44 6.67 26.67 6.67 2.22 peptidyl-prolyl cis-trans isomerase activity * * * GO_0003916(6) 66.67 20 0 0 0 0 13.33 DNA topoisomerase activity * * * GO_0016866(9) 91.67 0 5.56 0 0 0 2.78 intramolecular transferase activity * * GO_0016829(70) 95.9 2.48 0.25 0.29 0.33 0.29 0.46 lyase activity * * * GO_0016835(30) 94.48 3.68 0.46 0.23 0.23 0.46 0.46 carbon-oxygen lyase activity * * * * GO_0016836(24) 94.2 3.26 0.72 0.36 0.36 0.36 0.72 hydro-lyase activity * * * * * GO_0004730(7) 71.43 9.52 9.52 4.76 0 4.76 0 pseudouridylate synthase activity * * * GO_0016830(25) 94 0.67 0 0.67 0.67 1.33 2.67 carbon-carbon lyase activity * * * * GO_0016831(17) 91.18 0 0 0.74 0 2.94 5.15 carboxy-lyase activity * * * GO_0016846(6) 86.67 0 0 0 13.33 0 0 carbon-sulfur lyase activity * * GO_0016787(596) 95.6 3.51 0.3 0.15 0.24 0.11 0.08 hydrolase activity * * * GO_0019213(20) 82.63 7.89 2.63 1.05 3.68 0.53 1.58 deacetylase activity * * * * GO_0004407(18) 79.08 9.8 3.27 1.31 4.58 0.65 1.31 histone deacetylase activity * * * * * GO_0045129(6) 80 6.67 13.33 0 0 0 0 NAD-independent histone deacetylase activity * * * * * GO_0017136(7) 76.19 9.52 9.52 0 4.76 0 0 NAD-dependent histone deacetylase activity * * * GO_0016817(195) 88.89 6.52 1.24 0.77 1.49 0.77 0.33 "hydrolase activity, acting on acid anhydrides" * * * * GO_0016820(45) 86.46 2.32 2.02 3.74 2.02 1.82 1.62 "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" * * * * * GO_0042626(43) 85.6 2.1 2.21 4.1 2.21 1.99 1.77 "ATPase activity, coupled to transmembrane movement of substances" * * * * * * GO_0042625(30) 85.75 1.84 1.61 3.68 3.91 2.07 1.15 "ATPase activity, coupled to transmembrane movement of ions" * * * * * * * GO_0019829(19) 92.4 2.92 0 1.75 1.75 0 1.17 cation-transporting ATPase activity * * * * * * * * GO_0046961(18) 92.16 2.61 0 1.96 1.96 0 1.31 "hydrogen-transporting ATPase activity, rotational mechanism" * * * * * * * GO_0015662(12) 30.3 0 10.61 19.7 21.21 13.64 4.55 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" * * * * GO_0016818(193) 88.7 6.61 1.26 0.78 1.52 0.78 0.34 "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" * * * * * GO_0016462(192) 88.63 6.64 1.28 0.79 1.53 0.79 0.34 pyrophosphatase activity * * * * * * GO_0017111(176) 86.92 7.48 1.51 0.94 1.82 0.94 0.4 nucleoside-triphosphatase activity * * * * * * * GO_0016887(134) 85.85 7.56 1.57 0.75 2.14 1.46 0.66 ATPase activity * * * * * * * * GO_0042623(93) 84.85 6.62 1.4 1.15 3.6 1.73 0.65 "ATPase activity, coupled" * * * * * * * * * GO_0042626(43) 85.6 2.1 2.21 4.1 2.21 1.99 1.77 "ATPase activity, coupled to transmembrane movement of substances" * * * * * * * * * * GO_0042625(30) 85.75 1.84 1.61 3.68 3.91 2.07 1.15 "ATPase activity, coupled to transmembrane movement of ions" * * * * * * * * * * * GO_0019829(19) 92.4 2.92 0 1.75 1.75 0 1.17 cation-transporting ATPase activity * * * * * * * * * * * * GO_0046961(18) 92.16 2.61 0 1.96 1.96 0 1.31 "hydrogen-transporting ATPase activity, rotational mechanism" * * * * * * * * * * * GO_0015662(12) 30.3 0 10.61 19.7 21.21 13.64 4.55 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" * * * * * * * * * GO_0008186(26) 37.23 13.85 4.31 1.23 31.38 10.15 1.85 RNA-dependent ATPase activity * * * * * * * * * * GO_0004004(26) 37.23 13.85 4.31 1.23 31.38 10.15 1.85 ATP-dependent RNA helicase activity * * * * * * * * * GO_0008094(17) 77.94 5.15 1.47 0 2.21 12.5 0.74 DNA-dependent ATPase activity * * * * * * * * * * GO_0004003(11) 63.64 7.27 1.82 0 0 27.27 0 ATP-dependent DNA helicase activity * * * * * * * * * GO_0008026(42) 59.12 12.78 3.95 1.39 15.21 6.27 1.28 ATP-dependent helicase activity * * * * * * * * * * GO_0004003(11) 63.64 7.27 1.82 0 0 27.27 0 ATP-dependent DNA helicase activity * * * * * * * * * * GO_0004004(26) 37.23 13.85 4.31 1.23 31.38 10.15 1.85 ATP-dependent RNA helicase activity * * * * * * * GO_0003924(41) 56.71 14.15 8.54 9.15 10.12 0.98 0.37 GTPase activity * * * GO_0016810(52) 93.82 4.22 0.68 0.15 0.53 0.08 0.53 "hydrolase activity, acting on carbon-nitrogen " * * * * GO_0016814(17) 89.71 6.62 2.21 0 0 0 1.47 "hydrolase activity, acting on carbon-nitrogen " * * * * * GO_0019238(7) 90.48 0 0 0 0 0 9.52 cyclohydrolase activity * * * * GO_0016811(29) 90.64 4.43 1.23 0.49 1.72 0.25 1.23 "hydrolase activity, acting on carbon-nitrogen " * * * * * GO_0004407(18) 79.08 9.8 3.27 1.31 4.58 0.65 1.31 histone deacetylase activity * * * * * * GO_0045129(6) 80 6.67 13.33 0 0 0 0 NAD-independent histone deacetylase activity * * * * * * GO_0017136(7) 76.19 9.52 9.52 0 4.76 0 0 NAD-dependent histone deacetylase activity * * * GO_0016798(37) 92.49 4.65 0.6 0.15 0 0.6 1.5 "hydrolase activity, acting on glycosyl bonds" * * * * GO_0016799(7) 71.43 19.05 0 0 0 4.76 4.76 "hydrolase activity, hydrolyzing N-glycosyl compounds" * * * * * GO_0019104(7) 71.43 19.05 0 0 0 4.76 4.76 DNA N-glycosylase activity * * * * GO_0004553(28) 91.53 4.5 0.53 0.26 0 0.79 2.38 "hydrolase activity, hydrolyzing O-glycosyl compounds" * * * * * GO_0015926(11) 92.73 3.64 0 0 0 1.82 1.82 glucosidase activity * * * GO_0016788(197) 95.63 3.45 0.25 0.11 0.21 0.14 0.2 "hydrolase activity, acting on ester bonds" * * * * GO_0042578(80) 93.64 3.67 0.6 0.28 0.6 0.63 0.57 phosphoric ester hydrolase activity * * * * * GO_0016791(74) 92.78 4.07 0.7 0.33 0.7 0.74 0.67 phosphoric monoester hydrolase activity * * * * * * GO_0004721(38) 84.21 7.11 1.99 1 1.56 2.56 1.56 phosphoprotein phosphatase activity * * * * * * * GO_0004722(24) 77.9 6.16 1.45 1.09 2.9 6.52 3.99 protein serine/threonine phosphatase activity * * * * * * * * GO_0015071(6) 6.67 26.67 6.67 20 33.33 0 6.67 protein phosphatase type 2C activity * * * * * * * * GO_0000158(7) 80.95 4.76 0 0 0 9.52 4.76 protein phosphatase type 2A activity * * * * * * * GO_0004725(7) 61.9 19.05 4.76 4.76 9.52 0 0 protein tyrosine phosphatase activity * * * * * * GO_0004437(8) 85.71 0 3.57 3.57 3.57 3.57 0 inositol or phosphatidylinositol phosphatase activity * * * * * * GO_0019203(6) 86.67 0 0 0 0 6.67 6.67 carbohydrate phosphatase activity * * * * * GO_0008081(7) 100 0 0 0 0 0 0 phosphoric diester hydrolase activity * * * * GO_0016789(22) 90.48 3.9 0.87 0 0.87 0.43 3.46 carboxylic ester hydrolase activity * * * * * GO_0016298(12) 84.85 3.03 1.52 0 0 0 10.61 lipase activity * * * * * * GO_0004620(7) 66.67 4.76 0 0 0 0 28.57 phospholipase activity * * * * GO_0004518(90) 94.21 4.09 0.45 0.32 0.5 0.15 0.27 nuclease activity * * * * * GO_0004540(48) 96.19 3.1 0.44 0.09 0.09 0 0.09 ribonuclease activity * * * * * * GO_0004549(14) 98.9 1.1 0 0 0 0 0 tRNA-specific ribonuclease activity * * * * * * * GO_0004526(10) 97.78 2.22 0 0 0 0 0 ribonuclease P activity * * * * * * GO_0004532(23) 92.09 5.14 1.98 0 0.4 0 0.4 exoribonuclease activity * * * * * * * GO_0016896(23) 92.09 5.14 1.98 0 0.4 0 0.4 "exoribonuclease activity, producing 5'-phosphomonoesters" * * * * * * * * GO_0000175(18) 91.5 5.88 1.96 0 0.65 0 0 3'-5'-exoribonuclease activity * * * * * * GO_0004521(23) 97.63 2.37 0 0 0 0 0 endoribonuclease activity * * * * * * * GO_0016891(16) 97.5 2.5 0 0 0 0 0 "endoribonuclease activity, producing 5'-phosphomonoesters" * * * * * * * * GO_0004526(10) 97.78 2.22 0 0 0 0 0 ribonuclease P activity * * * * * * GO_0000171(9) 97.22 2.78 0 0 0 0 0 ribonuclease MRP activity * * * * * GO_0004536(17) 87.5 8.82 0.74 0.74 1.47 0.74 0 deoxyribonuclease activity * * * * * * GO_0004520(15) 85.71 9.52 0.95 0.95 1.9 0.95 0 endodeoxyribonuclease activity * * * * * GO_0004527(35) 92.77 4.03 1.01 0.84 0.67 0.17 0.5 exonuclease activity * * * * * * GO_0016796(24) 92.75 4.71 1.81 0 0.36 0 0.36 "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" * * * * * * * GO_0016896(23) 92.09 5.14 1.98 0 0.4 0 0.4 "exoribonuclease activity, producing 5'-phosphomonoesters" * * * * * * * * GO_0000175(18) 91.5 5.88 1.96 0 0.65 0 0 3'-5'-exoribonuclease activity * * * * * * GO_0008408(26) 93.23 4 1.23 0.31 0.92 0 0.31 3'-5' exonuclease activity * * * * * * * GO_0000175(18) 91.5 5.88 1.96 0 0.65 0 0 3'-5'-exoribonuclease activity * * * * * * GO_0004532(23) 92.09 5.14 1.98 0 0.4 0 0.4 exoribonuclease activity * * * * * * * GO_0016896(23) 92.09 5.14 1.98 0 0.4 0 0.4 "exoribonuclease activity, producing 5'-phosphomonoesters" * * * * * * * * GO_0000175(18) 91.5 5.88 1.96 0 0.65 0 0 3'-5'-exoribonuclease activity * * * * * GO_0004519(55) 92.86 4.65 0.47 0.47 0.81 0.34 0.4 endonuclease activity * * * * * * GO_0016893(21) 96.19 3.33 0 0.48 0 0 0 "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" * * * * * * * GO_0016891(16) 97.5 2.5 0 0 0 0 0 "endoribonuclease activity, producing 5'-phosphomonoesters" * * * * * * * * GO_0004526(10) 97.78 2.22 0 0 0 0 0 ribonuclease P activity * * * * * * GO_0004521(23) 97.63 2.37 0 0 0 0 0 endoribonuclease activity * * * * * * * GO_0016891(16) 97.5 2.5 0 0 0 0 0 "endoribonuclease activity, producing 5'-phosphomonoesters" * * * * * * * * GO_0004526(10) 97.78 2.22 0 0 0 0 0 ribonuclease P activity * * * * * * GO_0004520(15) 85.71 9.52 0.95 0.95 1.9 0.95 0 endodeoxyribonuclease activity * * * GO_0008233(102) 91.07 3.53 1.51 1.48 1.49 0.56 0.35 peptidase activity * * * * GO_0008238(14) 89.01 2.2 2.2 2.2 1.1 0 3.3 exopeptidase activity * * * * * GO_0004177(9) 88.89 0 2.78 5.56 0 0 2.78 aminopeptidase activity * * * * * GO_0008235(6) 80 6.67 13.33 0 0 0 0 metalloexopeptidase activity * * * * GO_0008237(22) 86.58 6.93 1.73 0.87 1.73 0.43 1.73 metallopeptidase activity * * * * * GO_0004222(13) 84.62 7.69 1.28 1.28 2.56 1.28 1.28 metalloendopeptidase activity * * * * * GO_0008235(6) 80 6.67 13.33 0 0 0 0 metalloexopeptidase activity * * * * GO_0008234(24) 52.17 6.16 13.04 17.39 9.06 1.09 1.09 cysteine-type peptidase activity * * * * * GO_0004843(17) 11.03 5.15 26.47 34.56 18.38 2.21 2.21 ubiquitin-specific protease activity * * * * GO_0004175(58) 89.23 3.57 2 1.45 2.12 1.33 0.3 endopeptidase activity * * * * * GO_0004222(13) 84.62 7.69 1.28 1.28 2.56 1.28 1.28 metalloendopeptidase activity * * * * * GO_0004190(7) 0 9.52 4.76 28.57 28.57 14.29 14.29 aspartic-type endopeptidase activity * * * * GO_0008236(6) 86.67 0 6.67 0 6.67 0 0 serine-type peptidase activity * * * GO_0017171(6) 80 0 0 6.67 6.67 6.67 0 serine hydrolase activity * * GO_0016740(542) 94.8 2.78 0.53 0.97 0.77 0.08 0.07 transferase activity * * * GO_0016772(245) 85.49 3.48 2.3 4.67 3.67 0.22 0.17 "transferase activity, transferring phosphorus-containing groups" * * * * GO_0016779(73) 94.86 3.92 0.46 0.11 0.19 0.04 0.42 nucleotidyltransferase activity * * * * * GO_0003899(35) 93.45 3.7 0.67 0.5 0.34 0 1.34 DNA-directed RNA polymerase activity * * * * * GO_0003887(20) 90.53 6.32 1.05 0 1.05 0.53 0.53 DNA-directed DNA polymerase activity * * * * GO_0016773(133) 60.3 4.72 7.31 14.95 11.75 0.63 0.35 "phosphotransferase activity, alcohol group as acceptor" * * * * * GO_0004672(94) 25.14 5.51 14.37 29.83 23.5 1.14 0.5 protein kinase activity * * * * * * GO_0004674(65) 18.89 5.19 17.31 33.65 22.45 1.59 0.91 protein serine/threonine kinase activity * * * * * * * GO_0004693(6) 33.33 0 0 0 26.67 40 0 cyclin-dependent protein kinase activity * * * * * * * GO_0004680(7) 47.62 0 19.05 9.52 4.76 14.29 4.76 casein kinase activity * * * * * * * GO_0004702(8) 0 0 0 42.86 42.86 10.71 3.57 receptor signaling protein serine/threonine kinase activity * * * * * * GO_0004713(6) 0 0 26.67 53.33 20 0 0 protein-tyrosine kinase activity * * * * * GO_0004428(12) 72.73 6.06 6.06 7.58 3.03 1.52 3.03 inositol or phosphatidylinositol kinase activity * * * * GO_0016301(161) 70.45 4.28 5.17 10.82 8.48 0.5 0.31 kinase activity * * * * * GO_0019205(10) 66.67 11.11 0 8.89 8.89 0 4.44 "nucleobase, nucleoside, nucleotide kinase activity" * * * * * * GO_0019201(6) 40 20 0 0 26.67 0 13.33 nucleotide kinase activity * * * * * GO_0004672(94) 25.14 5.51 14.37 29.83 23.5 1.14 0.5 protein kinase activity * * * * * * GO_0004674(65) 18.89 5.19 17.31 33.65 22.45 1.59 0.91 protein serine/threonine kinase activity * * * * * * * GO_0004693(6) 33.33 0 0 0 26.67 40 0 cyclin-dependent protein kinase activity * * * * * * * GO_0004680(7) 47.62 0 19.05 9.52 4.76 14.29 4.76 casein kinase activity * * * * * * * GO_0004702(8) 0 0 0 42.86 42.86 10.71 3.57 receptor signaling protein serine/threonine kinase activity * * * * * * GO_0004713(6) 0 0 26.67 53.33 20 0 0 protein-tyrosine kinase activity * * * * * GO_0019200(15) 78.1 1.9 5.71 0 0 8.57 5.71 carbohydrate kinase activity * * * * * GO_0001727(8) 53.57 7.14 14.29 10.71 7.14 3.57 3.57 lipid kinase activity * * * * * GO_0004428(12) 72.73 6.06 6.06 7.58 3.03 1.52 3.03 inositol or phosphatidylinositol kinase activity * * * * GO_0016780(7) 95.24 0 4.76 0 0 0 0 "phosphotransferase activity, for other substituted phosphate groups" * * * * GO_0016776(6) 40 20 0 0 26.67 0 13.33 "phosphotransferase activity, phosphate group as acceptor" * * * * GO_0016778(6) 33.33 0 0 0 0 46.67 20 diphosphotransferase activity * * * GO_0016769(17) 79.41 8.82 3.68 0 5.88 0.74 1.47 "transferase activity, transferring nitrogenous groups" * * * * GO_0008483(15) 80 5.71 4.76 0 6.67 0.95 1.9 transaminase activity * * * GO_0016765(31) 93.98 2.8 0.86 0.43 0.86 0.22 0.86 "transferase activity, transferring alkyl or aryl " * * * * GO_0004659(10) 86.67 0 2.22 4.44 6.67 0 0 prenyltransferase activity * * * GO_0016757(89) 94.13 3.7 0.43 0.23 0.13 0.77 0.61 "transferase activity, transferring glycosyl groups" * * * * GO_0016758(71) 92.39 4.51 0.68 0.28 0.2 1.01 0.93 "transferase activity, transferring hexosyl groups" * * * * * GO_0046527(14) 87.91 3.3 0 0 0 3.3 5.49 glucosyltransferase activity * * * * * * GO_0035251(13) 85.9 3.85 0 0 0 3.85 6.41 UDP-glucosyltransferase activity * * * * * GO_0004576(10) 86.67 11.11 2.22 0 0 0 0 oligosaccharyl transferase activity * * * * * * GO_0004579(9) 88.89 8.33 2.78 0 0 0 0 dolichyl-diphosphooligosaccharide-protein glycotransferase activity * * * * * GO_0000030(37) 86.34 4.65 2.25 0.45 0.6 3.3 2.4 mannosyltransferase activity * * * * * * GO_0000009(8) 78.57 3.57 0 3.57 3.57 7.14 3.57 "alpha-1,6-mannosyltransferase activity" * * * * * * GO_0004169(6) 0 0 0 0 0 66.67 33.33 dolichyl-phosphate-mannose-protein mannosyltransferase activity * * * * * * GO_0000026(6) 66.67 20 0 0 0 0 13.33 "alpha-1,2-mannosyltransferase activity" * * * * GO_0008194(17) 83.82 7.35 0.74 1.47 0 2.21 4.41 UDP-glycosyltransferase activity * * * * * GO_0035251(13) 85.9 3.85 0 0 0 3.85 6.41 UDP-glucosyltransferase activity * * * * GO_0016763(16) 87.5 5.83 0 1.67 0 4.17 0.83 "transferase activity, transferring pentosyl groups" * * * GO_0016746(81) 95.46 3.06 0.43 0.03 0.31 0.28 0.43 "transferase activity, transferring acyl groups" * * * * GO_0016747(73) 95.32 3.2 0.38 0.04 0.38 0.3 0.38 "transferase activity, transferring groups other than amino-acyl groups" * * * * * GO_0008415(73) 95.32 3.2 0.38 0.04 0.38 0.3 0.38 acyltransferase activity * * * * * * GO_0016410(38) 93.31 4.98 0.71 0.14 0.28 0.28 0.28 N-acyltransferase activity * * * * * * * GO_0008080(33) 92.42 5.68 0.95 0.19 0.38 0.38 0 N-acetyltransferase activity * * * * * * * * GO_0004468(18) 89.54 7.84 0 0 1.31 1.31 0 lysine N-acetyltransferase activity * * * * * * * * * GO_0004402(18) 89.54 7.84 0 0 1.31 1.31 0 histone acetyltransferase activity * * * * * * * * GO_0004596(7) 76.19 4.76 14.29 4.76 0 0 0 peptide alpha-N-acetyltransferase activity * * * * * * GO_0016407(44) 93.34 4.76 0.63 0.11 0.32 0.63 0.21 acetyltransferase activity * * * * * * * GO_0008080(33) 92.42 5.68 0.95 0.19 0.38 0.38 0 N-acetyltransferase activity * * * * * * * * GO_0004468(18) 89.54 7.84 0 0 1.31 1.31 0 lysine N-acetyltransferase activity * * * * * * * * * GO_0004402(18) 89.54 7.84 0 0 1.31 1.31 0 histone acetyltransferase activity * * * * * * * * GO_0004596(7) 76.19 4.76 14.29 4.76 0 0 0 peptide alpha-N-acetyltransferase activity * * * * * * * GO_0016413(7) 66.67 0 0 0 4.76 19.05 9.52 O-acetyltransferase activity * * * * * * GO_0008374(14) 85.71 3.3 0 0 1.1 4.4 5.49 O-acyltransferase activity * * * * * * * GO_0016413(7) 66.67 0 0 0 4.76 19.05 9.52 O-acetyltransferase activity * * * * * * GO_0004312(8) 78.57 0 7.14 0 0 7.14 7.14 fatty-acid synthase activity * * * * * * GO_0016417(7) 85.71 0 9.52 0 4.76 0 0 S-acyltransferase activity * * * * GO_0046912(7) 57.14 0 19.05 0 0 4.76 19.05 "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer" * * * GO_0016741(69) 93.61 5.2 0.38 0.13 0.3 0 0.38 "transferase activity, transferring one-carbon groups" * * * * GO_0008168(67) 93.58 5.25 0.36 0.09 0.32 0 0.41 methyltransferase activity * * * * * GO_0008757(43) 92.47 5.98 0.55 0.22 0.33 0 0.44 S-adenosylmethionine-dependent methyltransferase activity * * * * * * GO_0016278(11) 87.27 5.45 1.82 3.64 1.82 0 0 lysine N-methyltransferase activity * * * * * * * GO_0016279(11) 87.27 5.45 1.82 3.64 1.82 0 0 protein-lysine N-methyltransferase activity * * * * * * * * GO_0018024(9) 86.11 2.78 2.78 5.56 2.78 0 0 histone-lysine N-methyltransferase activity * * * * * * * * * GO_0042800(8) 85.71 3.57 3.57 3.57 3.57 0 0 histone lysine N-methyltransferase activity * * * * * * GO_0016423(7) 71.43 23.81 0 0 0 0 4.76 tRNA * * * * * GO_0008276(15) 92.38 3.81 0.95 1.9 0.95 0 0 protein methyltransferase activity * * * * * * GO_0042054(10) 88.89 2.22 2.22 4.44 2.22 0 0 histone methyltransferase activity * * * * * * * GO_0018024(9) 86.11 2.78 2.78 5.56 2.78 0 0 histone-lysine N-methyltransferase activity * * * * * * * * GO_0042800(8) 85.71 3.57 3.57 3.57 3.57 0 0 histone lysine N-methyltransferase activity * * * * * * GO_0016279(11) 87.27 5.45 1.82 3.64 1.82 0 0 protein-lysine N-methyltransferase activity * * * * * * * GO_0018024(9) 86.11 2.78 2.78 5.56 2.78 0 0 histone-lysine N-methyltransferase activity * * * * * * * * GO_0042800(8) 85.71 3.57 3.57 3.57 3.57 0 0 histone lysine N-methyltransferase activity * * * * * GO_0008173(24) 89.13 8.33 0.36 0 1.45 0 0.72 RNA methyltransferase activity * * * * * * GO_0008175(15) 89.52 8.57 0.95 0 0 0 0.95 tRNA methyltransferase activity * * * * * * * GO_0016423(7) 71.43 23.81 0 0 0 0 4.76 tRNA * * * * * GO_0008170(20) 90 7.37 0.53 1.05 0.53 0 0.53 N-methyltransferase activity * * * * * * GO_0016278(11) 87.27 5.45 1.82 3.64 1.82 0 0 lysine N-methyltransferase activity * * * * * * * GO_0016279(11) 87.27 5.45 1.82 3.64 1.82 0 0 protein-lysine N-methyltransferase activity * * * * * * * * GO_0018024(9) 86.11 2.78 2.78 5.56 2.78 0 0 histone-lysine N-methyltransferase activity * * * * * * * * * GO_0042800(8) 85.71 3.57 3.57 3.57 3.57 0 0 histone lysine N-methyltransferase activity * * * * * GO_0004372(7) 76.19 4.76 4.76 0 0 0 14.29 glycine hydroxymethyltransferase activity * * GO_0016491(209) 96.46 2.55 0.31 0.17 0.19 0.07 0.24 oxidoreductase activity * * * GO_0016903(18) 89.54 4.58 0 0 0 1.96 3.92 "oxidoreductase activity, acting on the aldehyde or oxo group of donors" * * * * GO_0016620(14) 86.81 3.3 0 0 0 3.3 6.59 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" * * * GO_0016684(14) 85.71 5.49 0 1.1 4.4 1.1 2.2 "oxidoreductase activity, acting on peroxide as acceptor" * * * * GO_0004601(14) 85.71 5.49 0 1.1 4.4 1.1 2.2 peroxidase activity * * * GO_0016679(9) 94.44 2.78 2.78 0 0 0 0 "oxidoreductase activity, acting on diphenols and related substances as donors" * * * * GO_0016681(9) 94.44 2.78 2.78 0 0 0 0 "oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor" * * * * * GO_0008121(9) 94.44 2.78 2.78 0 0 0 0 ubiquinol-cytochrome-c reductase activity * * * GO_0016675(13) 96.15 1.28 0 0 0 1.28 1.28 "oxidoreductase activity, acting on heme group of donors" * * * * GO_0016676(13) 96.15 1.28 0 0 0 1.28 1.28 "oxidoreductase activity, acting on heme group of donors, oxygen as acceptor" * * * * * GO_0004129(13) 96.15 1.28 0 0 0 1.28 1.28 cytochrome-c oxidase activity * * * GO_0016645(13) 93.59 1.28 0 2.56 0 0 2.56 "oxidoreductase activity, acting on the CH-NH group of donors" * * * * GO_0016646(12) 92.42 1.52 0 3.03 0 0 3.03 "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor" * * * GO_0016627(15) 89.52 4.76 0 2.86 0.95 0 1.9 "oxidoreductase activity, acting on the CH-CH group of donors" * * * * GO_0016628(7) 90.48 4.76 0 0 0 0 4.76 "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor" * * * GO_0016614(58) 91.17 4.05 1.09 1.21 0.97 0.48 1.03 "oxidoreductase activity, acting on CH-OH group of donors" * * * * GO_0016616(50) 89.96 4.33 1.06 1.63 1.14 0.65 1.22 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" * * * * * GO_0004033(8) 53.57 7.14 0 0 25 7.14 7.14 aldo-keto reductase activity * * * GO_0015002(13) 96.15 1.28 0 0 0 1.28 1.28 heme-copper terminal oxidase activity * * * * GO_0004129(13) 96.15 1.28 0 0 0 1.28 1.28 cytochrome-c oxidase activity * * * GO_0016651(8) 89.29 0 0 0 3.57 0 7.14 "oxidoreductase activity, acting on NADH or NADPH" * * * GO_0016705(6) 80 13.33 0 0 0 0 6.67 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" * * * GO_0016722(6) 53.33 0 20 0 13.33 0 13.33 "oxidoreductase activity, oxidizing metal ions" * * * GO_0015036(6) 40 20 6.67 13.33 13.33 6.67 0 disulfide oxidoreductase activity * * * GO_0016667(9) 80.56 8.33 2.78 0 5.56 0 2.78 "oxidoreductase activity, acting on sulfur group of donors" * * GO_0008639(18) 39.22 3.27 5.88 18.95 32.03 0.65 0 small protein conjugating enzyme activity * * * GO_0004840(15) 24.76 3.81 7.62 22.86 40 0.95 0 ubiquitin conjugating enzyme activity * * GO_0004386(64) 59.97 16.07 6.35 1.59 9.92 3.57 2.53 helicase activity * * * GO_0008026(42) 59.12 12.78 3.95 1.39 15.21 6.27 1.28 ATP-dependent helicase activity * * * * GO_0004003(11) 63.64 7.27 1.82 0 0 27.27 0 ATP-dependent DNA helicase activity * * * * GO_0004004(26) 37.23 13.85 4.31 1.23 31.38 10.15 1.85 ATP-dependent RNA helicase activity * * * GO_0003724(33) 33.9 15.34 6.06 3.79 29.73 9.09 2.08 RNA helicase activity * * * * GO_0004004(26) 37.23 13.85 4.31 1.23 31.38 10.15 1.85 ATP-dependent RNA helicase activity * * * GO_0003678(26) 75.08 9.85 3.69 0.31 1.23 4.92 4.92 DNA helicase activity * * * * GO_0004003(11) 63.64 7.27 1.82 0 0 27.27 0 ATP-dependent DNA helicase activity * * GO_0019239(11) 80 14.55 5.45 0 0 0 0 deaminase activity * * GO_0008641(7) 14.29 4.76 9.52 38.1 23.81 4.76 4.76 small protein activating enzyme activity * GO_0003774(16) 59.17 10 7.5 2.5 10 3.33 7.5 motor activity * * GO_0003777(6) 13.33 6.67 6.67 6.67 53.33 6.67 6.67 microtubule motor activity * * GO_0000146(6) 33.33 0 0 0 0 13.33 53.33 microfilament motor activity