This file contains the complete listing of clusters of GO molecular functions assigned to proteins in experimental datasets of S. cerevisiae and C. elegans, respectively. each cluster is accompanied with a representing keyword and its corresponding ln P value. ************************************************************************************************ CLUSTER 1: represntative keyword: binding, ln p(n)= -33.5 GO:0003723 RNA binding F GO:0000166 nucleotide binding F GO:0003677 DNA binding F GO:0003676 nucleic acid binding F GO:0000339 RNA cap binding F GO:0008097 5S rRNA binding F GO:0042134 rRNA primary transcript binding F GO:0030515 snoRNA binding F GO:0003729 mRNA binding F GO:0008312 7S RNA binding F GO:0019843 rRNA binding F GO:0019001 guanyl nucleotide binding F GO:0003680 AT DNA binding F GO:0000217 DNA secondary structure binding F GO:0003690 double-stranded DNA binding F GO:0003697 single-stranded DNA binding F GO:0003725 double-stranded RNA binding F GO:0017069 snRNA binding F GO:0008134 transcription factor binding F GO:0003684 damaged DNA binding F GO:0019237 centromeric DNA binding F GO:0042162 telomeric DNA binding F GO:0003688 DNA replication origin binding F GO:0045142 triplex DNA binding F GO:0000049 tRNA binding F GO:0000182 rDNA binding F GO:0030620 U2 snRNA binding F GO:0008139 nuclear localization sequence binding F GO:0005515 protein binding F GO:0042802 protein self binding F GO:0030674 "protein binding, bridging" F GO:0048306 calcium-dependent protein binding F GO:0016597 amino acid binding F GO:0008092 cytoskeletal protein binding F GO:0051082 unfolded protein binding F GO:0019904 protein domain specific binding F GO:0031072 heat shock protein binding F GO:0019901 protein kinase binding F GO:0043021 ribonucleoprotein binding F GO:0005519 cytoskeletal regulatory protein binding F GO:0008157 protein phosphatase 1 binding F GO:0005524 ATP binding F GO:0005525 GTP binding F GO:0051287 NAD binding F GO:0050660 FAD binding F GO:0008536 Ran GTPase binding F GO:0050661 NADP binding F GO:0017048 Rho GTPase binding F GO:0048037 cofactor binding F GO:0010181 FMN binding F GO:0017137 Rab GTPase binding F GO:0051020 GTPase binding F GO:0016208 AMP binding F GO:0008270 zinc ion binding F GO:0005509 calcium ion binding F GO:0005506 iron ion binding F GO:0046872 metal ion binding F GO:0030145 manganese ion binding F GO:0005507 copper ion binding F GO:0008199 ferric iron binding F GO:0000287 magnesium ion binding F GO:0030276 clathrin binding F GO:0003779 actin binding F GO:0005545 phosphatidylinositol binding F GO:0008143 poly(A) binding F GO:0005529 sugar binding F GO:0003682 chromatin binding F GO:0005048 signal sequence binding F GO:0051015 actin filament binding F GO:0009374 biotin binding F GO:0030976 thiamin pyrophosphate binding F GO:0035091 phosphoinositide binding F GO:0017022 myosin binding F GO:0015631 tubulin binding F GO:0042393 histone binding F GO:0005543 phospholipid binding F GO:0020037 heme binding F GO:0003785 actin monomer binding F GO:0000149 SNARE binding F GO:0030170 pyridoxal phosphate binding F GO:0008289 lipid binding F GO:0008017 microtubule binding F GO:0005053 peroxisome targeting signal-2 binding F GO:0051087 chaperone binding F GO:0043176 amine binding F GO:0043035 chromatin insulator sequence binding F GO:0045159 myosin II binding F GO:0008190 eukaryotic initiation factor 4E binding F GO:0000268 peroxisome targeting sequence binding F GO:0005052 peroxisome targeting signal-1 binding F GO:0005536 glucose binding F GO:0043325 "phosphatidylinositol-3,4-bisphosphate binding" F GO:0017024 myosin I binding F GO:0043130 ubiquitin binding F GO:0030332 cyclin binding F GO:0030246 carbohydrate binding F GO:0031177 phosphopantetheine binding F GO:0003786 actin lateral binding F GO:0019840 isoprenoid binding F GO:0005047 signal recognition particle binding F GO:0005537 mannose binding F GO:0043014 alpha-tubulin binding F GO:0050839 cell adhesion molecule binding F GO:0048487 beta-tubulin binding F GO:0048039 ubiquinone binding F GO:0005488 binding F /// CLUSTER 2: represntative keyword: ase activity, ln p(n)= -160.0 GO:0008168 methyltransferase activity F GO:0004682 protein kinase CK2 activity F GO:0004672 protein kinase activity F GO:0004674 protein serine/threonine kinase activity F GO:0004713 protein-tyrosine kinase activity F GO:0046961 "hydrogen-transporting ATPase activity, rotational mechanism" F GO:0046933 "hydrogen-transporting ATP synthase activity, rotational mechanism" F GO:0016887 ATPase activity F GO:0004175 endopeptidase activity F GO:0016787 hydrolase activity F GO:0017111 nucleoside-triphosphatase activity F GO:0004601 peroxidase activity F GO:0004691 cAMP-dependent protein kinase activity F GO:0004679 AMP-activated protein kinase activity F GO:0003899 DNA-directed RNA polymerase activity F GO:0000175 3'-5'-exoribonuclease activity F GO:0004842 ubiquitin-protein ligase activity F GO:0003924 GTPase activity F GO:0004004 ATP-dependent RNA helicase activity F GO:0008026 ATP-dependent helicase activity F GO:0004386 helicase activity F GO:0016779 nucleotidyltransferase activity F GO:0008235 metalloexopeptidase activity F GO:0008121 ubiquinol-cytochrome-c reductase activity F GO:0004222 metalloendopeptidase activity F GO:0017136 NAD-dependent histone deacetylase activity F GO:0045129 NAD-independent histone deacetylase activity F GO:0015071 protein phosphatase type 2C activity F GO:0004059 aralkylamine N-acetyltransferase activity F GO:0004145 diamine N-acetyltransferase activity F GO:0008080 N-acetyltransferase activity F GO:0004402 histone acetyltransferase activity F GO:0004722 protein serine/threonine phosphatase activity F GO:0003855 3-dehydroquinate dehydratase activity F GO:0003856 3-dehydroquinate synthase activity F GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity F GO:0004764 shikimate 5-dehydrogenase activity F GO:0004765 shikimate kinase activity F GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity F GO:0004086 carbamoyl-phosphate synthase activity F GO:0016874 ligase activity F GO:0003872 6-phosphofructokinase activity F GO:0004617 phosphoglycerate dehydrogenase activity F GO:0016616 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" F GO:0004298 threonine endopeptidase activity F GO:0004749 ribose phosphate diphosphokinase activity F GO:0016978 lipoate-protein ligase B activity F GO:0004721 phosphoprotein phosphatase activity F GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity F GO:0008415 acyltransferase activity F GO:0004250 aminopeptidase I activity F GO:0004176 ATP-dependent peptidase activity F GO:0004252 serine-type endopeptidase activity F GO:0004693 cyclin-dependent protein kinase activity F GO:0016301 kinase activity F GO:0008173 RNA methyltransferase activity F GO:0004596 peptide alpha-N-acetyltransferase activity F GO:0004042 amino-acid N-acetyltransferase activity F GO:0004550 nucleoside diphosphate kinase activity F GO:0004652 polynucleotide adenylyltransferase activity F GO:0000163 protein phosphatase type 1 activity F GO:0000158 protein phosphatase type 2A activity F GO:0003724 RNA helicase activity F GO:0003938 IMP dehydrogenase activity F GO:0004540 ribonuclease activity F GO:0008408 3'-5' exonuclease activity F GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity F GO:0004407 histone deacetylase activity F GO:0004730 pseudouridylate synthase activity F GO:0004818 glutamate-tRNA ligase activity F GO:0004812 tRNA ligase activity F GO:0004525 ribonuclease III activity F GO:0004559 alpha-mannosidase activity F GO:0015923 mannosidase activity F GO:0000179 "rRNA (adenine-N6,N6-)-dimethyltransferase activity" F GO:0016433 rRNA (adenine) methyltransferase activity F GO:0008649 rRNA methyltransferase activity F GO:0008757 S-adenosylmethionine-dependent methyltransferase activity F GO:0004680 casein kinase activity F GO:0016435 rRNA (guanine) methyltransferase activity F GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity F GO:0004518 nuclease activity F GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity F GO:0004406 H3/H4 histone acetyltransferase activity F GO:0008276 protein methyltransferase activity F GO:0008170 N-methyltransferase activity F GO:0004016 adenylate cyclase activity F GO:0016849 phosphorus-oxygen lyase activity F GO:0003893 epsilon DNA polymerase activity F GO:0003887 DNA-directed DNA polymerase activity F GO:0003678 DNA helicase activity F GO:0004003 ATP-dependent DNA helicase activity F GO:0016818 "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" F GO:0004827 proline-tRNA ligase activity F GO:0016773 "phosphotransferase activity, alcohol group as acceptor" F GO:0003934 GTP cyclohydrolase I activity F GO:0004240 mitochondrial processing peptidase activity F GO:0004707 MAP kinase activity F GO:0016791 phosphoric monoester hydrolase activity F GO:0004449 isocitrate dehydrogenase (NAD+) activity F GO:0016491 oxidoreductase activity F GO:0047046 homoisocitrate dehydrogenase activity F GO:0016966 nitric oxide reductase activity F GO:0043138 3' to 5' DNA helicase activity F GO:0004148 dihydrolipoyl dehydrogenase activity F GO:0015036 disulfide oxidoreductase activity F GO:0004122 cystathionine beta-synthase activity F GO:0004373 glycogen (starch) synthase activity F GO:0003989 acetyl-CoA carboxylase activity F GO:0004075 biotin carboxylase activity F GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity F GO:0016624 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor" F GO:0004526 ribonuclease P activity F GO:0004843 ubiquitin-specific protease activity F GO:0004197 cysteine-type endopeptidase activity F GO:0004221 ubiquitin thiolesterase activity F GO:0004366 glycerol-3-phosphate O-acyltransferase activity F GO:0004527 exonuclease activity F GO:0004349 glutamate 5-kinase activity F GO:0016279 protein-lysine N-methyltransferase activity F GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity F GO:0004618 phosphoglycerate kinase activity F GO:0004660 protein farnesyltransferase activity F GO:0004661 protein geranylgeranyltransferase activity F GO:0008318 protein prenyltransferase activity F GO:0003825 "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity" F GO:0003963 RNA-3'-phosphate cyclase activity F GO:0004484 mRNA guanylyltransferase activity F GO:0004022 alcohol dehydrogenase activity F GO:0004350 glutamate-5-semialdehyde dehydrogenase activity F GO:0003883 CTP synthase activity F GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity F GO:0004519 endonuclease activity F GO:0003917 DNA topoisomerase type I activity F GO:0000150 recombinase activity F GO:0017017 MAP kinase phosphatase activity F GO:0008138 protein tyrosine/serine/threonine phosphatase activity F GO:0042054 histone methyltransferase activity F GO:0016274 protein-arginine N-methyltransferase activity F GO:0004555 "alpha,alpha-trehalase activity" F GO:0004615 phosphomannomutase activity F GO:0004822 isoleucine-tRNA ligase activity F GO:0004828 serine-tRNA ligase activity F GO:0003755 peptidyl-prolyl cis-trans isomerase activity F GO:0004072 aspartate kinase activity F GO:0004712 protein threonine/tyrosine kinase activity F GO:0016820 "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" F GO:0004823 leucine-tRNA ligase activity F GO:0008094 DNA-dependent ATPase activity F GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity F GO:0004709 MAP kinase kinase kinase activity F GO:0004708 MAP kinase kinase activity F GO:0005078 MAP-kinase scaffold activity F GO:0003891 delta DNA polymerase activity F GO:0019706 protein-cysteine S-palmitoleyltransferase activity F GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity F GO:0008379 thioredoxin peroxidase activity F GO:0003916 DNA topoisomerase activity F GO:0016407 acetyltransferase activity F GO:0004725 protein tyrosine phosphatase activity F GO:0004520 endodeoxyribonuclease activity F GO:0017108 5'-flap endonuclease activity F GO:0016667 "oxidoreductase activity, acting on sulfur group of donors" F GO:0004781 sulfate adenylyltransferase (ATP) activity F GO:0004092 carnitine O-acetyltransferase activity F GO:0004697 protein kinase C activity F GO:0042623 "ATPase activity, coupled" F GO:0004437 inositol or phosphatidylinositol phosphatase activity F GO:0004735 pyrroline-5-carboxylate reductase activity F GO:0008466 glycogenin glucosyltransferase activity F GO:0016758 "transferase activity, transferring hexosyl groups" F GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity F GO:0004638 phosphoribosylaminoimidazole carboxylase activity F GO:0008193 tRNA guanylyltransferase activity F GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity F GO:0004126 cytidine deaminase activity F GO:0004515 nicotinate-nucleotide adenylyltransferase activity F GO:0000309 nicotinamide-nucleotide adenylyltransferase activity F GO:0004364 glutathione transferase activity F GO:0004849 uridine kinase activity F GO:0004067 asparaginase activity F GO:0016811 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" F GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity F GO:0016810 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" F GO:0004634 phosphopyruvate hydratase activity F GO:0004108 citrate (Si)-synthase activity F GO:0046912 "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer" F GO:0004748 ribonucleoside-diphosphate reductase activity F GO:0004170 dUTP diphosphatase activity F GO:0004131 cytosine deaminase activity F GO:0004794 threonine ammonia-lyase activity F GO:0050291 sphingosine N-acyltransferase activity F GO:0004655 porphobilinogen synthase activity F GO:0015926 glucosidase activity F GO:0004587 ornithine-oxo-acid transaminase activity F GO:0008483 transaminase activity F GO:0008251 tRNA specific adenosine deaminase activity F GO:0008174 mRNA methyltransferase activity F GO:0004809 tRNA (guanine-N2-)-methyltransferase activity F GO:0016855 "racemase and epimerase activity, acting on amino acids and derivatives" F GO:0004535 poly(A)-specific ribonuclease activity F GO:0008175 tRNA methyltransferase activity F GO:0008233 peptidase activity F GO:0000721 "(R,R)-butanediol dehydrogenase activity" F GO:0004327 formaldehyde dehydrogenase (glutathione) activity F GO:0004100 chitin synthase activity F GO:0004430 1-phosphatidylinositol 4-kinase activity F GO:0004335 galactokinase activity F GO:0004553 "hydrolase activity, hydrolyzing O-glycosyl compounds" F GO:0004590 orotidine-5'-phosphate decarboxylase activity F GO:0004681 casein kinase I activity F GO:0004053 arginase activity F GO:0004289 subtilase activity F GO:0016742 "hydroxymethyl-, formyl- and related transferase activity" F GO:0004644 phosphoribosylglycinamide formyltransferase activity F GO:0004733 pyridoxamine-phosphate oxidase activity F GO:0008898 homocysteine S-methyltransferase activity F GO:0000906 "6,7-dimethyl-8-ribityllumazine synthase activity" F GO:0004746 riboflavin synthase activity F GO:0016740 transferase activity F GO:0003999 adenine phosphoribosyltransferase activity F GO:0008311 double-stranded DNA specific 3'-5' exodeoxyribonuclease activity F GO:0004528 phosphodiesterase I activity F GO:0016298 lipase activity F GO:0004806 triacylglycerol lipase activity F GO:0004629 phospholipase C activity F GO:0005286 basic amino acid permease activity F GO:0000213 tRNA-intron endonuclease activity F GO:0008863 formate dehydrogenase activity F GO:0004129 cytochrome-c oxidase activity F GO:0015450 protein translocase activity F GO:0008534 purine-specific oxidized base lesion DNA N-glycosylase activity F GO:0000034 adenine deaminase activity F GO:0019239 deaminase activity F GO:0004000 adenosine deaminase activity F GO:0019170 D-lactaldehyde dehydrogenase activity F GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity F GO:0008553 "hydrogen-exporting ATPase activity, phosphorylative mechanism" F GO:0015662 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" F GO:0003869 4-nitrophenylphosphatase activity F GO:0004035 alkaline phosphatase activity F GO:0016620 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" F GO:0030693 caspase activity F GO:0042781 3'-tRNA processing endoribonuclease activity F GO:0004151 dihydroorotase activity F GO:0016812 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides" F GO:0004564 beta-fructofuranosidase activity F GO:0008237 metallopeptidase activity F GO:0004165 dodecenoyl-CoA delta-isomerase activity F GO:0004791 thioredoxin-disulfide reductase activity F GO:0000030 mannosyltransferase activity F GO:0003889 alpha DNA polymerase activity F GO:0004521 endoribonuclease activity F GO:0004301 epoxide hydrolase activity F GO:0000253 3-keto sterol reductase activity F GO:0004848 ureidoglycolate hydrolase activity F GO:0004451 isocitrate lyase activity F GO:0004571 "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity" F GO:0003951 NAD+ kinase activity F GO:0000907 sulfonate dioxygenase activity F GO:0016431 tRNA (uridine) methyltransferase activity F GO:0004354 glutamate dehydrogenase (NADP+) activity F GO:0016889 "endodeoxyribonuclease activity, producing 3'-phosphomonoesters" F GO:0004124 cysteine synthase activity F GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity F GO:0016765 "transferase activity, transferring alkyl or aryl (other than methyl) groups" F GO:0004417 hydroxyethylthiazole kinase activity F GO:0004789 thiamin-phosphate diphosphorylase activity F GO:0004427 inorganic diphosphatase activity F GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity F GO:0016769 "transferase activity, transferring nitrogenous groups" F GO:0017005 tyrosyl-DNA phosophodiesterase activity F GO:0008081 phosphoric diester hydrolase activity F GO:0004340 glucokinase activity F GO:0004396 hexokinase activity F GO:0009982 pseudouridine synthase activity F GO:0000121 glycerol-1-phosphatase activity F GO:0004648 phosphoserine transaminase activity F GO:0017150 tRNA dihydrouridine synthase activity F GO:0004310 farnesyl-diphosphate farnesyltransferase activity F GO:0016788 "hydrolase activity, acting on ester bonds" F GO:0004352 glutamate dehydrogenase activity F GO:0004475 mannose-1-phosphate guanylyltransferase activity F GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity F GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity F GO:0004685 calcium- and calmodulin-dependent protein kinase activity F GO:0004772 sterol O-acyltransferase activity F GO:0004534 5'-3' exoribonuclease activity F GO:0042578 phosphoric ester hydrolase activity F GO:0003852 2-isopropylmalate synthase activity F GO:0004523 ribonuclease H activity F GO:0004338 "glucan 1,3-beta-glucosidase activity" F GO:0030060 L-malate dehydrogenase activity F GO:0004459 L-lactate dehydrogenase activity F GO:0016615 malate dehydrogenase activity F GO:0004736 pyruvate carboxylase activity F GO:0016891 "endoribonuclease activity, producing 5'-phosphomonoesters" F GO:0042626 "ATPase activity, coupled to transmembrane movement of substances" F GO:0004329 formate-tetrahydrofolate ligase activity F GO:0004477 methenyltetrahydrofolate cyclohydrolase activity F GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity F GO:0003984 acetolactate synthase activity F GO:0004622 lysophospholipase activity F GO:0004620 phospholipase activity F GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity F GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity F GO:0000247 C-8 sterol isomerase activity F GO:0016655 "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" F GO:0008902 hydroxymethylpyrimidine kinase activity F GO:0008972 phosphomethylpyrimidine kinase activity F GO:0004179 membrane alanyl aminopeptidase activity F GO:0009003 signal peptidase activity F GO:0003987 acetate-CoA ligase activity F GO:0004164 diphthine synthase activity F GO:0004421 hydroxymethylglutaryl-CoA synthase activity F GO:0016868 "intramolecular transferase activity, phosphotransferases" F GO:0004345 glucose-6-phosphate 1-dehydrogenase activity F GO:0008409 5'-3' exonuclease activity F GO:0004851 uroporphyrin-III C-methyltransferase activity F GO:0004372 glycine hydroxymethyltransferase activity F GO:0046547 trans-aconitate 3-methyltransferase activity F GO:0003905 alkylbase DNA N-glycosylase activity F GO:0008752 FMN reductase activity F GO:0046421 methylisocitrate lyase activity F GO:0004413 homoserine kinase activity F GO:0046526 D-xylulose reductase activity F GO:0042132 fructose-bisphosphatase activity F GO:0008839 dihydrodipicolinate reductase activity F GO:0008686 "3,4-dihydroxy-2-butanone-4-phosphate synthase activity" F GO:0000215 tRNA 2'-phosphotransferase activity F GO:0016772 "transferase activity, transferring phosphorus-containing groups" F GO:0000107 imidazoleglycerol-phosphate synthase activity F GO:0016763 "transferase activity, transferring pentosyl groups" F GO:0042602 flavin reductase activity F GO:0004107 chorismate synthase activity F GO:0008131 amine oxidase activity F GO:0004314 [acyl-carrier protein] S-malonyltransferase activity F GO:0004186 carboxypeptidase C activity F GO:0004185 serine carboxypeptidase activity F GO:0019789 SUMO ligase activity F GO:0004536 deoxyribonuclease activity F GO:0004619 phosphoglycerate mutase activity F GO:0019238 cyclohydrolase activity F GO:0003935 GTP cyclohydrolase II activity F GO:0004096 catalase activity F GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity F GO:0008234 cysteine-type peptidase activity F GO:0016929 SUMO-specific protease activity F GO:0015359 amino acid permease activity F GO:0016706 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" F GO:0004754 "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity" F GO:0003923 GPI-anchor transamidase activity F GO:0004128 cytochrome-b5 reductase activity F GO:0004089 carbonate dehydratase activity F GO:0004445 inositol-polyphosphate 5-phosphatase activity F GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity F GO:0009922 fatty acid elongase activity F GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity F GO:0003994 aconitate hydratase activity F GO:0016836 hydro-lyase activity F GO:0016829 lyase activity F GO:0008859 exoribonuclease II activity F GO:0004325 ferrochelatase activity F GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity F GO:0004576 oligosaccharyl transferase activity F GO:0015039 NADPH-adrenodoxin reductase activity F GO:0004428 inositol or phosphatidylinositol kinase activity F GO:0000310 xanthine phosphoribosyltransferase activity F GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity F GO:0004028 aldehyde dehydrogenase activity F GO:0004702 receptor signaling protein serine/threonine kinase activity F GO:0047389 glycerophosphocholine phosphodiesterase activity F GO:0008889 glycerophosphodiester phosphodiesterase activity F GO:0050177 phenylpyruvate decarboxylase activity F GO:0016831 carboxy-lyase activity F GO:0004727 prenylated protein tyrosine phosphatase activity F GO:0000140 acylglycerone-phosphate reductase activity F GO:0004737 pyruvate decarboxylase activity F GO:0004362 glutathione-disulfide reductase activity F GO:0004573 mannosyl-oligosaccharide glucosidase activity F GO:0004642 phosphoribosylformylglycinamidine synthase activity F GO:0004585 ornithine carbamoyltransferase activity F GO:0016743 carboxyl- and carbamoyltransferase activity F GO:0008531 riboflavin kinase activity F GO:0003993 acid phosphatase activity F GO:0008897 phosphopantetheinyltransferase activity F GO:0005296 L-proline permease activity F GO:0004835 tubulin-tyrosine ligase activity F GO:0004055 argininosuccinate synthase activity F GO:0004377 glycolipid 2-alpha-mannosyltransferase activity F GO:0004602 glutathione peroxidase activity F GO:0009031 thiol peroxidase activity F GO:0004424 imidazoleglycerol-phosphate dehydratase activity F GO:0008440 inositol trisphosphate 3-kinase activity F GO:0004047 aminomethyltransferase activity F GO:0003756 protein disulfide isomerase activity F GO:0004814 arginine-tRNA ligase activity F GO:0004347 glucose-6-phosphate isomerase activity F GO:0043334 "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" F GO:0000171 ribonuclease MRP activity F GO:0008383 manganese superoxide dismutase activity F GO:0004784 superoxide dismutase activity F GO:0008450 O-sialoglycoprotein endopeptidase activity F GO:0004558 alpha-glucosidase activity F GO:0004556 alpha-amylase activity F GO:0004758 serine C-palmitoyltransferase activity F GO:0000009 "alpha-1,6-mannosyltransferase activity" F GO:0004382 guanosine-diphosphatase activity F GO:0045134 uridine-diphosphatase activity F GO:0016156 fumarate reductase (NADH) activity F GO:0000104 succinate dehydrogenase activity F GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity F GO:0004084 branched-chain-amino-acid transaminase activity F GO:0016439 tRNA-pseudouridine synthase activity F GO:0004026 alcohol O-acetyltransferase activity F GO:0004831 tyrosine-tRNA ligase activity F GO:0003850 2-deoxyglucose-6-phosphatase activity F GO:0008236 serine-type peptidase activity F GO:0042392 sphingosine-1-phosphate phosphatase activity F GO:0000334 "3-hydroxyanthranilate 3,4-dioxygenase activity" F GO:0004588 orotate phosphoribosyltransferase activity F GO:0004182 carboxypeptidase A activity F GO:0004467 long-chain-fatty-acid-CoA ligase activity F GO:0004422 hypoxanthine phosphoribosyltransferase activity F GO:0004012 phospholipid-translocating ATPase activity F GO:0004743 pyruvate kinase activity F GO:0004132 dCMP deaminase activity F GO:0004684 calmodulin-dependent protein kinase I activity F GO:0004637 phosphoribosylamine-glycine ligase activity F GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity F GO:0003876 AMP deaminase activity F GO:0004408 holocytochrome-c synthase activity F GO:0004032 aldehyde reductase activity F GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity F GO:0004045 aminoacyl-tRNA hydrolase activity F GO:0004190 aspartic-type endopeptidase activity F GO:0004747 ribokinase activity F GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity F GO:0016651 "oxidoreductase activity, acting on NADH or NADPH" F GO:0004529 exodeoxyribonuclease activity F GO:0004502 kynurenine 3-monooxygenase activity F GO:0004017 adenylate kinase activity F GO:0019201 nucleotide kinase activity F GO:0016776 "phosphotransferase activity, phosphate group as acceptor" F GO:0004830 tryptophan-tRNA ligase activity F GO:0004177 aminopeptidase activity F GO:0004568 chitinase activity F GO:0004438 phosphatidylinositol-3-phosphatase activity F GO:0008195 phosphatidate phosphatase activity F GO:0004034 aldose 1-epimerase activity F GO:0008177 succinate dehydrogenase (ubiquinone) activity F GO:0003919 FMN adenylyltransferase activity F GO:0004178 leucyl aminopeptidase activity F GO:0008793 aromatic-amino-acid transaminase activity F GO:0017057 6-phosphogluconolactonase activity F GO:0008934 inositol-1(or 4)-monophosphatase activity F GO:0003959 NADPH dehydrogenase activity F GO:0004309 exopolyphosphatase activity F GO:0016462 pyrophosphatase activity F GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity F GO:0016291 acyl-CoA thioesterase activity F GO:0004103 choline kinase activity F GO:0016768 spermine synthase activity F GO:0004024 "alcohol dehydrogenase activity, zinc-dependent" F GO:0004792 thiosulfate sulfurtransferase activity F GO:0045547 dehydrodolichyl diphosphate synthase activity F GO:0004123 cystathionine gamma-lyase activity F GO:0004109 coproporphyrinogen oxidase activity F GO:0004793 threonine aldolase activity F GO:0004056 argininosuccinate lyase activity F GO:0004731 purine-nucleoside phosphorylase activity F GO:0004019 adenylosuccinate synthase activity F GO:0004038 allantoinase activity F GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity F GO:0004450 isocitrate dehydrogenase (NADP+) activity F GO:0004146 dihydrofolate reductase activity F GO:0004614 phosphoglucomutase activity F GO:0004478 methionine adenosyltransferase activity F GO:0016702 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" F GO:0000298 endopolyphosphatase activity F GO:0004799 thymidylate synthase activity F GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity F GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity F GO:0004768 stearoyl-CoA 9-desaturase activity F GO:0003910 DNA ligase (ATP) activity F GO:0004802 transketolase activity F GO:0016992 lipoate synthase activity F GO:0004331 "fructose-2,6-bisphosphate 2-phosphatase activity" F GO:0016853 isomerase activity F GO:0004801 transaldolase activity F GO:0008670 "2,4-dienoyl-CoA reductase (NADPH) activity" F GO:0008892 guanine deaminase activity F GO:0004013 adenosylhomocysteinase activity F GO:0016830 carbon-carbon lyase activity F GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity F GO:0004594 pantothenate kinase activity F GO:0004376 glycolipid mannosyltransferase activity F GO:0004316 3-oxoacyl-[acyl-carrier protein] reductase activity F GO:0004226 Gly-X carboxypeptidase activity F GO:0000033 "alpha-1,3-mannosyltransferase activity" F GO:0004659 prenyltransferase activity F GO:0008106 alcohol dehydrogenase (NADP+) activity F GO:0004609 phosphatidylserine decarboxylase activity F GO:0004029 aldehyde dehydrogenase (NAD) activity F GO:0004416 hydroxyacylglutathione hydrolase activity F GO:0016627 "oxidoreductase activity, acting on the CH-CH group of donors" F GO:0004755 "saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity" F GO:0004751 ribose-5-phosphate isomerase activity F GO:0004771 sterol esterase activity F GO:0016789 carboxylic ester hydrolase activity F GO:0017050 D-erythro-sphingosine kinase activity F GO:0004143 diacylglycerol kinase activity F GO:0015646 permease activity F GO:0004821 histidine-tRNA ligase activity F GO:0016972 thiol oxidase activity F GO:0004243 mitochondrial intermediate peptidase activity F GO:0016806 dipeptidyl-peptidase and tripeptidyl-peptidase activity F GO:0004287 prolyl oligopeptidase activity F GO:0004274 dipeptidyl-peptidase IV activity F GO:0003890 beta DNA polymerase activity F GO:0004816 asparagine-tRNA ligase activity F GO:0004815 aspartate-tRNA ligase activity F GO:0004845 uracil phosphoribosyltransferase activity F GO:0004805 trehalose-phosphatase activity F GO:0003720 telomerase activity F GO:0008487 prenyl-dependent CAAX protease activity F GO:0004834 tryptophan synthase activity F GO:0004651 polynucleotide 5'-phosphatase activity F GO:0004244 mitochondrial inner membrane peptidase activity F GO:0004020 adenylylsulfate kinase activity F GO:0004161 dimethylallyltranstransferase activity F GO:0004337 geranyltranstransferase activity F GO:0008967 phosphoglycolate phosphatase activity F GO:0004775 succinate-CoA ligase (ADP-forming) activity F GO:0004592 pantoate-beta-alanine ligase activity F GO:0050483 IMP 5'-nucleotidase activity F GO:0004144 diacylglycerol O-acyltransferase activity F GO:0019171 3-hydroxyacyl-[acyl-carrier protein] dehydratase activity F GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity F GO:0004512 inositol-3-phosphate synthase activity F GO:0004115 cAMP-specific phosphodiesterase activity F GO:0004114 "3',5'-cyclic-nucleotide phosphodiesterase activity" F GO:0008176 tRNA (guanine-N7-)-methyltransferase activity F GO:0004356 glutamate-ammonia ligase activity F GO:0004322 ferroxidase activity F GO:0000293 ferric-chelate reductase activity F GO:0016428 tRNA (cytosine-5-)-methyltransferase activity F GO:0015505 uracil permease activity F GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity F GO:0016614 "oxidoreductase activity, acting on CH-OH group of donors" F GO:0008441 "3'(2'),5'-bisphosphate nucleotidase activity" F GO:0043115 precorrin-2 dehydrogenase activity F GO:0051266 sirohydrochlorin ferrochelatase activity F GO:0004091 carboxylesterase activity F GO:0017068 glutamyl-tRNA(Gln) amidotransferase activity F GO:0016884 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor" F GO:0004605 phosphatidate cytidylyltransferase activity F GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity F GO:0004073 aspartate-semialdehyde dehydrogenase activity F GO:0004385 guanylate kinase activity F GO:0005288 arginine permease activity F GO:0005293 lysine permease activity F GO:0000010 trans-hexaprenyltranstransferase activity F GO:0004040 amidase activity F GO:0004824 lysine-tRNA ligase activity F GO:0004788 thiamin diphosphokinase activity F GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity F GO:0000031 mannosylphosphate transferase activity F GO:0003991 acetylglutamate kinase activity F GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity F GO:0000026 "alpha-1,2-mannosyltransferase activity" F GO:0042736 NADH kinase activity F GO:0004647 phosphoserine phosphatase activity F GO:0004113 "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity" F GO:0003978 UDP-glucose 4-epimerase activity F GO:0008677 2-dehydropantoate 2-reductase activity F GO:0000277 [cytochrome c]-lysine N-methyltransferase activity F GO:0017171 serine hydrolase activity F GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity F GO:0003877 ATP adenylyltransferase activity F GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity F GO:0004392 heme oxygenase (decyclizing) activity F GO:0004516 nicotinate phosphoribosyltransferase activity F GO:0004826 phenylalanine-tRNA ligase activity F GO:0004829 threonine-tRNA ligase activity F GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity F GO:0016423 tRNA (guanine) methyltransferase activity F GO:0004640 phosphoribosylanthranilate isomerase activity F GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity F GO:0016757 "transferase activity, transferring glycosyl groups" F GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity F GO:0004332 fructose-bisphosphate aldolase activity F GO:0016218 polyketide synthase activity F GO:0003840 gamma-glutamyltransferase activity F GO:0004001 adenosine kinase activity F GO:0004099 chitin deacetylase activity F GO:0003937 IMP cyclohydrolase activity F GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity F GO:0003972 RNA ligase (ATP) activity F GO:0009049 aspartic-type signal peptidase activity F GO:0003896 DNA primase activity F GO:0004696 glycogen synthase kinase 3 activity F GO:0004371 glycerone kinase activity F GO:0004121 cystathionine beta-lyase activity F GO:0042124 "1,3-beta-glucanosyltransferase activity" F GO:0004049 anthranilate synthase activity F GO:0016833 oxo-acid-lyase activity F GO:0000703 pyrimidine-specific oxidized base lesion DNA N-glycosylase activity F GO:0004811 tRNA isopentenyltransferase activity F GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity F GO:0008495 protoheme IX farnesyltransferase activity F GO:0017173 DRAP deaminase activity F GO:0004134 4-alpha-glucanotransferase activity F GO:0004135 "amylo-alpha-1,6-glucosidase activity" F GO:0046820 4-amino-4-deoxychorismate synthase activity F GO:0004460 L-lactate dehydrogenase (cytochrome) activity F GO:0004435 phosphoinositide phospholipase C activity F GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity F GO:0008810 cellulase activity F GO:0016303 phosphatidylinositol 3-kinase activity F GO:0003997 acyl-CoA oxidase activity F GO:0003995 acyl-CoA dehydrogenase activity F GO:0008559 xenobiotic-transporting ATPase activity F GO:0000254 C-4 methylsterol oxidase activity F GO:0019829 cation-transporting ATPase activity F GO:0004008 copper-exporting ATPase activity F GO:0008843 endochitinase activity F GO:0000252 C-3 sterol dehydrogenase (C-4 sterodecarboxylase) activityl F GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity F GO:0004769 steroid delta-isomerase activity F GO:0004663 Rab-protein geranylgeranyltransferase activity F GO:0004825 methionine-tRNA ligase activity F GO:0004106 chorismate mutase activity F GO:0004130 cytochrome-c peroxidase activity F GO:0004785 "copper, zinc superoxide dismutase activity" F GO:0046975 histone lysine N-methyltransferase activity (H3-K36 specific) F GO:0004069 aspartate transaminase activity F GO:0004412 homoserine dehydrogenase activity F GO:0004807 triose-phosphate isomerase activity F GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity F GO:0004363 glutathione synthase activity F GO:0004798 thymidylate kinase activity F GO:0009041 uridylate kinase activity F GO:0004714 transmembrane receptor protein tyrosine kinase activity F GO:0008184 glycogen phosphorylase activity F GO:0004645 phosphorylase activity F GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity F GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity F GO:0004476 mannose-6-phosphate isomerase activity F GO:0004351 glutamate decarboxylase activity F GO:0008375 acetylglucosaminyltransferase activity F GO:0008989 rRNA (guanine-N1-)-methyltransferase activity F GO:0016424 tRNA (guanosine) methyltransferase activity F GO:0003992 acetylornithine transaminase activity F GO:0004630 phospholipase D activity F GO:0008478 pyridoxal kinase activity F GO:0017061 S-methyl-5-thioadenosine phosphorylase activity F GO:0017125 deoxycytidyl transferase activity F GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity F GO:0003894 zeta DNA polymerase activity F GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity F GO:0004497 monooxygenase activity F GO:0004311 farnesyltranstransferase activity F GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity F GO:0015431 glutathione S-conjugate-exporting ATPase activity F GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity F GO:0004061 arylformamidase activity F GO:0003861 3-isopropylmalate dehydratase activity F GO:0005388 calcium-transporting ATPase activity F GO:0015410 manganese-transporting ATPase activity F GO:0004239 methionyl aminopeptidase activity F GO:0004820 glycine-tRNA ligase activity F GO:0004474 malate synthase activity F GO:0000170 sphingosine hydroxylase activity F GO:0004399 histidinol dehydrogenase activity F GO:0004635 phosphoribosyl-AMP cyclohydrolase activity F GO:0004636 phosphoribosyl-ATP diphosphatase activity F GO:0019187 "beta-1,4-mannosyltransferase activity" F GO:0004458 D-lactate dehydrogenase (cytochrome) activity F GO:0042283 "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity" F GO:0003880 C-terminal protein carboxyl methyltransferase activity F GO:0015392 cytosine-purine permease activity F GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity F GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity F GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity F GO:0004608 phosphatidylethanolamine N-methyltransferase activity F GO:0008453 alanine-glyoxylate transaminase activity F GO:0003843 "1,3-beta-glucan synthase activity" F GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity F GO:0003867 4-aminobutyrate transaminase activity F GO:0004795 threonine synthase activity F GO:0003721 telomeric template RNA reverse transcriptase activity F GO:0003964 RNA-directed DNA polymerase activity F GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity F GO:0004455 ketol-acid reductoisomerase activity F GO:0004379 glycylpeptide N-tetradecanoyltransferase activity F GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity F GO:0008330 protein tyrosine/threonine phosphatase activity F GO:0004357 glutamate-cysteine ligase activity F GO:0030337 DNA polymerase processivity factor activity F GO:0016532 superoxide dismutase copper chaperone activity F GO:0003824 152 catalytic activity F GO:0019781 2 NEDD8 activating enzyme activity F GO:0004839 3 ubiquitin activating enzyme activity F GO:0008642 17 ubiquitin-like activating enzyme activity F GO:0004840 14 ubiquitin conjugating enzyme activity F GO:0042292 1 URM1 activating enzyme activity F GO:0008640 3 ubiquitin-like conjugating enzyme activity F GO:0008419 1 RNA lariat debranching enzyme activity F GO:0004470 1 malic enzyme activity F GO:0019948 2 SUMO activating enzyme activity F GO:0003844 1 1,4-alpha-glucan branching enzyme activity F GO:0008605 protein kinase CK2 regulator activity F GO:0019207 kinase regulator activity F GO:0008603 cAMP-dependent protein kinase regulator activity F GO:0008599 protein phosphatase type 1 regulator activity F GO:0008601 protein phosphatase type 2A regulator activity F GO:0016538 cyclin-dependent protein kinase regulator activity F GO:0005083 small GTPase regulator activity F GO:0019888 protein phosphatase regulator activity F GO:0019887 protein kinase regulator activity F GO:0030295 protein kinase activator activity F GO:0019211 phosphatase activator activity F GO:0005100 Rho GTPase activator activity F GO:0019209 kinase activator activity F GO:0005096 GTPase activator activity F GO:0005099 Ras GTPase activator activity F GO:0008060 ARF GTPase activator activity F GO:0005098 Ran GTPase activator activity F GO:0005097 Rab GTPase activator activity F GO:0004862 cAMP-dependent protein kinase inhibitor activity F GO:0004860 protein kinase inhibitor activity F GO:0004861 cyclin-dependent protein kinase inhibitor activity F GO:0004864 protein phosphatase inhibitor activity F GO:0019210 kinase inhibitor activity F GO:0004866 endopeptidase inhibitor activity F GO:0001671 ATPase stimulator activity F GO:0030234 13 enzyme regulator activity F GO:0030192 1 Hsp70/Hsc70 protein regulator activity F GO:0016299 1 regulator of G-protein signaling activity F GO:0000156 4 two-component response regulator activity F GO:0016247 1 channel regulator activity F GO:0008047 12 enzyme activator activity F GO:0008538 2 proteasome activator activity F GO:0030189 2 chaperone activator activity F GO:0005093 1 Rab GDP-dissociation inhibitor activity F GO:0004857 3 enzyme inhibitor activity F GO:0005094 1 Rho GDP-dissociation inhibitor activity F /// CLUSTER 3: represntative keyword: porter activity, ln p(n)= -165 GO:0005489 24 electron transporter activity F GO:0005215 73 transporter activity F GO:0008565 62 protein transporter activity F GO:0005487 3 nucleocytoplasmic transporter activity F GO:0005478 5 intracellular transporter activity F GO:0008519 3 ammonium transporter activity F GO:0015168 1 glycerol transporter activity F GO:0005315 4 inorganic phosphate transporter activity F GO:0015239 2 multidrug transporter activity F GO:0015238 4 drug transporter activity F GO:0005385 3 zinc ion transporter activity F GO:0008324 7 cation transporter activity F GO:0015203 3 polyamine transporter activity F GO:0005279 25 amino acid-polyamine transporter activity F GO:0015344 1 siderophore-iron (ferrioxamine) uptake transporter activity F GO:0015077 1 monovalent inorganic cation transporter activity F GO:0015299 3 solute:hydrogen antiporter activity F GO:0015385 2 sodium:hydrogen antiporter activity F GO:0008526 3 phosphatidylinositol transporter activity F GO:0005384 4 manganese ion transporter activity F GO:0005351 22 sugar porter activity F GO:0015079 1 potassium ion transporter activity F GO:0015489 1 putrescine transporter activity F GO:0005338 2 nucleotide-sugar transporter activity F GO:0015520 1 tetracycline:hydrogen antiporter activity F GO:0015116 1 sulfate transporter activity F GO:0008271 3 sulfate porter activity F GO:0015386 1 potassium:hydrogen antiporter activity F GO:0001406 1 glycerophosphodiester transporter activity F GO:0005290 1 L-histidine transporter activity F GO:0046873 8 metal ion transporter activity F GO:0015491 2 cation:cation antiporter activity F GO:0015175 3 neutral amino acid transporter activity F GO:0015171 9 amino acid transporter activity F GO:0005353 10 fructose transporter activity F GO:0005355 11 glucose transporter activity F GO:0015578 10 mannose transporter activity F GO:0005381 6 iron ion transporter activity F GO:0005354 5 galactose transporter activity F GO:0005471 1 ATP:ADP antiporter activity F GO:0015173 1 aromatic amino acid transporter activity F GO:0005476 1 carnitine:acyl carnitine antiporter activity F GO:0015319 1 sodium:inorganic phosphate symporter activity F GO:0015114 2 phosphate transporter activity F GO:0015095 2 magnesium ion transporter activity F GO:0005275 1 amine transporter activity F GO:0015151 1 alpha-glucoside transporter activity F GO:0005342 1 organic acid transporter activity F GO:0015191 1 L-methionine transporter activity F GO:0005375 3 copper ion transporter activity F GO:0015088 2 copper uptake transporter activity F GO:0000297 3 spermine transporter activity F GO:0015157 1 oligosaccharide transporter activity F GO:0005319 1 lipid transporter activity F GO:0015082 1 di-, tri-valent inorganic cation transporter activity F GO:0015213 1 uridine transporter activity F GO:0015606 2 spermidine transporter activity F GO:0015297 1 antiporter activity F GO:0015174 3 basic amino acid transporter activity F GO:0015197 1 peptide transporter activity F GO:0015230 1 FAD transporter activity F GO:0000319 1 sulfite transporter activity F GO:0015234 1 thiamin transporter activity F GO:0005310 1 dicarboxylic acid transporter activity F GO:0005352 1 alpha-glucoside:hydrogen symporter activity F GO:0005364 1 maltose:hydrogen symporter activity F GO:0015574 1 trehalose transporter activity F GO:0000102 1 L-methionine porter activity F GO:0015124 1 allantoate transporter activity F GO:0015105 1 arsenite transporter activity F GO:0008508 1 bile acid:sodium symporter activity F GO:0008028 1 monocarboxylic acid transporter activity F GO:0005337 1 nucleoside transporter activity F GO:0015220 1 choline transporter activity F GO:0015127 2 bilirubin transporter activity F GO:0015086 1 cadmium ion transporter activity F GO:0000295 1 adenine nucleotide transporter activity F GO:0015226 1 carnitine transporter activity F GO:0046624 1 sphingolipid transporter activity F GO:0015233 1 pantothenate transporter activity F GO:0005324 1 long-chain fatty acid transporter activity F GO:0015078 1 hydrogen ion transporter activity F GO:0015198 1 oligopeptide transporter activity F GO:0015232 1 heme transporter activity F GO:0005365 1 myo-inositol transporter activity F GO:0000095 1 S-adenosylmethionine transporter activity F GO:0000006 1 high affinity zinc uptake transporter activity F GO:0001409 1 guanine nucleotide transporter activity F GO:0045153 1 electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity F GO:0015205 5 nucleobase transporter activity F /// CLUTER 4: representative keyword: transcription activity, ln p(n)= -34.9 GO:0016566 8 specific transcriptional repressor activity F GO:0003700 107 transcription factor activity F GO:0016986 3 transcription initiation factor activity F GO:0003712 8 transcription cofactor activity F GO:0003714 12 transcription corepressor activity F GO:0016564 10 transcriptional repressor activity F GO:0016565 2 general transcriptional repressor activity F GO:0008159 2 positive transcription elongation factor activity F GO:0003706 1 ligand-regulated transcription factor activity F GO:0016944 16 RNA polymerase II transcription elongation factor activity F GO:0003711 3 transcriptional elongation regulator activity F GO:0016251 36 general RNA polymerase II transcription factor activity F GO:0030528 30 transcription regulator activity F GO:0016563 33 transcriptional activator activity F GO:0003713 10 transcription coactivator activity F GO:0003702 21 RNA polymerase II transcription factor activity F GO:0016455 21 RNA polymerase II transcription mediator activity F GO:0003701 8 RNA polymerase I transcription factor activity F GO:0003704 31 specific RNA polymerase II transcription factor activity F GO:0003709 9 RNA polymerase III transcription factor activity F GO:0003716 1 RNA polymerase I transcription termination factor activity F /// CLUSTER 5: representative keyword: translation activity, ln p(n)=-28.3 GO:0003743 31 translation initiation factor activity F GO:0030371 3 translation repressor activity F GO:0003746 10 translation elongation factor activity F GO:0008135 1 translation factor activity, nucleic acid binding F GO:0016149 "translation release factor activity, codon specific" F GO:0003747 translation release factor activity F GO:0045182 7 translation regulator activity F GO:0004694 1 eukaryotic translation initiation factor 2alpha kinase activity F /// CLUSTER 6: representative keyword: ribosome, ln p(n)=-7.03 GO:0003735 133 structural constituent of ribosome F GO:0043022 1 ribosome binding F /// CLUSTER 7: representative keyword: receptor activity, ln p(n)=-42.8 GO:0004888 4 transmembrane receptor activity F GO:0008262 2 importin-alpha export receptor activity F GO:0004872 6 receptor activity F GO:0004934 1 mating-type alpha-factor pheromone receptor activity F GO:0004932 1 mating-type factor pheromone receptor activity F GO:0005484 2 SNAP receptor activity F GO:0005057 1 receptor signaling protein activity F GO:0004930 1 G-protein coupled receptor activity F GO:0005006 1 epidermal growth factor receptor activity F GO:0008158 1 hedgehog receptor activity F GO:0005485 14 v-SNARE activity F GO:0005486 10 t-SNARE activity F /// CLUSTER 8: representative keyword: structural activity, ln p(n)= -4.13 GO:0005198 51 structural molecule activity F GO:0005200 47 structural constituent of cytoskeleton F /// CLUSTER 9: representative keyword: splicing activity, ln p(n)= -4.69 GO:0031202 34 RNA splicing factor activity, transesterification mechanism F /// CLUSTER 10: representative keyword: growth activity, ln p(n)= -8.9 GO:0008083 1 growth factor activity F /// CLUSTER 11: representative keyword: loader activity, ln p(n)= -6.82 GO:0003689 6 DNA clamp loader activity F /// CLUSTER 12: representative keyword: exchange activity, ln p(n)= -28.3 GO:0005085 18 guanyl-nucleotide exchange factor activity F GO:0030508 3 thiol-disulfide exchange intermediate activity F GO:0005088 2 Ras guanyl-nucleotide exchange factor activity F GO:0005086 5 ARF guanyl-nucleotide exchange factor activity F GO:0005089 4 Rho guanyl-nucleotide exchange factor activity F GO:0017112 2 Rab guanyl-nucleotide exchange factor activity F GO:0000774 2 adenyl-nucleotide exchange factor activity F /// CLUSTER 13: representative keyword: dimerization activity, ln p(n)=-17.5 GO:0046983 8 protein dimerization activity F GO:0046982 2 protein heterodimerization activity F GO:0042803 1 protein homodimerization activity F /// CLUSTER 14: representative keyword: motor activity, ln p(n)= -15.6 GO:0000146 6 microfilament motor activity F GO:0003774 8 motor activity F GO:0003777 9 microtubule motor activity F /// CLUSTER 15: representative keyword: transducer activity, ln p(n)= -5.6 GO:0004871 27 signal transducer activity F /// CLUSTER 16: representative keyword: carrier activity, ln p(n)= -34.7 GO:0008320 13 protein carrier activity F GO:0009055 5 electron carrier activity F GO:0000036 1 acyl carrier activity F GO:0005477 1 pyruvate carrier activity F GO:0005371 1 tricarboxylate carrier activity F GO:0005386 1 carrier activity F GO:0000227 1 oxaloacetate carrier activity F /// CLUSTER 17: representative keyword: nuclear pore, ln p(n)= -6.44 GO:0017056 7 structural constituent of nuclear pore F /// /// CLUSTER 18: representative keyword: structural chromatin, ln p(n)= -7.92 GO:0030527 2 structural constituent of chromatin F /// CLUSTER 19: representative keyword: protein tag, ln p(n)= -8.20 GO:0031386 3 protein tag F /// CLUSTER 20: representative keyword: annealing activity, ln p(n)= -7.92 GO:0000739 2 DNA strand annealing activity F /// CLUSTER 21: representative keyword: escort activity, ln p(n)= -8.61 GO:0005084 1 Rab escort protein activity F /// CLUSTER 22: representative keyword: bending activity, ln p(n)= -7.11 GO:0008301 6 DNA bending activity F /// CLUSTER 23: representative keyword: guide activity, ln p(n)= -7.92 GO:0030559 2 rRNA pseudouridylation guide activity F /// CLUSTER 24: representative keyword: attachment activity, ln p(n)= -8.39 GO:0005483 1 soluble NSF attachment protein activity F /// CLUSTER 25: representative keyword: sensor activity, ln p(n)= -13.6 GO:0005034 3 osmosensor activity F GO:0000155 2 two-component sensor molecule activity F /// CLUSTER 26: representative keyword: cell wall, ln p(n)= -6.44 GO:0005199 7 structural constituent of cell wall F /// CLUSTER 27: representative keyword: channel activity, ln p(n)= -40.3 GO:0008308 1 voltage-gated ion-selective channel activity F GO:0005267 1 potassium channel activity F GO:0005216 3 ion channel activity F GO:0005247 1 voltage-gated chloride channel activity F GO:0005254 1 chloride channel activity F GO:0005262 1 calcium channel activity F GO:0005261 1 cation channel activity F /// CLUSTER 28: representative keyword: pheromone activity, ln p(n)= -7.51 GO:0000772 4 mating pheromone activity F /// CLUSTER 29: representative keyword: pepsin activity, ln p(n)= -13.0 GO:0004194 7 pepsin A activity F GO:0004196 1 saccharopepsin activity F /// CLUSTER 30: representative keyword: calpain activity, ln p(n)= -9.30 GO:0004198 1 calpain activity F /// CLUSTER 31: representative keyword: pump activity, ln p(n)= -7.22 GO:0015559 4 multidrug efflux pump activity F /// CLUSTER 32: representative keyword: legumain activity, ln p(n)= -9.30 GO:0001509 1 legumain activity F /// CLUSTER 33: representative keyword: cytokine activity, ln p(n)= -9.30 GO:0005125 1 cytokine activity F /// CLUSTER 34: representative keyword: saccharolysin activity, ln p(n)= -9.30 GO:0004247 1 saccharolysin activity F /// CLUSTER 35: representative keyword: chaperone activity, ln p(n)= -20.2 GO:0016530 1 metallochaperone activity F GO:0016531 2 copper chaperone activity F /// ********************************************************************* ********************************************************************* ********************************************************************* ********************************************************************* ********************************************************************* ********************************************************************* ********************************************************************* ********************************************************************* CLUSTER 1: represntative keyword: ribosome, ln p(n)= -3.79 GO:0003735 80 structural constituent of ribosome F /// CLUSTER 2: represntative keyword: transcription activity, ln p(n)= -22.1 GO:0003700 108 transcription factor activity F GO:0030528 14 transcription regulator activity F GO:0008159 1 positive transcription elongation factor activity F GO:0016564 3 transcriptional repressor activity F GO:0003702 4 RNA polymerase II transcription factor activity F GO:0003712 4 transcription cofactor activity F GO:0016563 1 transcriptional activator activity F GO:0003713 1 transcription coactivator activity F GO:0016986 2 transcription initiation factor activity F /// CLUSTER 3: represntative keyword: translation activity, ln p(n)= -12.1 GO:0003743 19 translation initiation factor activity F GO:0003746 7 translation elongation factor activity F GO:0016149 1 "translation release factor activity, codon specific" F /// CLUSTER 4: represntative keyword: binding, ln p(n)= -11.0 GO:0003676 188 nucleic acid binding F GO:0000166 161 nucleotide binding F GO:0003677 196 DNA binding F GO:0003684 8 damaged DNA binding F GO:0003723 82 RNA binding F GO:0003725 8 double-stranded RNA binding F GO:0019001 2 guanyl nucleotide binding F GO:0008097 1 5S rRNA binding F GO:0003697 1 single-stranded DNA binding F GO:0019843 1 rRNA binding F GO:0030515 1 snoRNA binding F GO:0008312 1 7S RNA binding F GO:0005515 1276 protein binding F GO:0042802 44 protein self binding F GO:0051082 12 unfolded protein binding F GO:0008092 3 cytoskeletal protein binding F GO:0019904 4 protein domain specific binding F GO:0031072 6 heat shock protein binding F GO:0019901 1 protein kinase binding F GO:0016597 3 amino acid binding F GO:0008022 1 protein C-terminus binding F GO:0005080 1 protein kinase C binding F GO:0005524 264 ATP binding F GO:0005525 48 GTP binding F GO:0051287 10 NAD binding F GO:0050660 5 FAD binding F GO:0050661 1 NADP binding F GO:0010181 2 FMN binding F GO:0008270 182 zinc ion binding F GO:0005509 51 calcium ion binding F GO:0046872 85 metal ion binding F GO:0005506 36 iron ion binding F GO:0008199 3 ferric iron binding F GO:0030145 4 manganese ion binding F GO:0050897 2 cobalt ion binding F GO:0000287 9 magnesium ion binding F GO:0030151 1 molybdenum ion binding F GO:0005507 3 copper ion binding F GO:0003682 5 chromatin binding F GO:0005529 28 sugar binding F GO:0003779 14 actin binding F GO:0020037 18 heme binding F GO:0008017 3 microtubule binding F GO:0008061 7 chitin binding F GO:0005516 1 calmodulin binding F GO:0005544 2 calcium-dependent phospholipid binding F GO:0008289 8 lipid binding F GO:0045296 2 cadherin binding F GO:0017134 1 fibroblast growth factor binding F GO:0030276 1 clathrin binding F GO:0005545 1 phosphatidylinositol binding F GO:0031419 1 cobalamin binding F GO:0009374 2 biotin binding F GO:0019992 1 diacylglycerol binding F GO:0019894 1 kinesin binding F GO:0005496 2 steroid binding F GO:0030170 2 pyridoxal phosphate binding F GO:0051087 1 chaperone binding F GO:0005542 1 folic acid binding F GO:0008430 1 selenium binding F GO:0051537 1 "2 iron, 2 sulfur cluster binding" F GO:0031177 1 phosphopantetheine binding F GO:0000062 1 acyl-CoA binding F GO:0031405 1 lipoic acid binding F GO:0030976 1 thiamin pyrophosphate binding F GO:0005543 1 phospholipid binding F GO:0050839 1 cell adhesion molecule binding F GO:0005488 110 binding F /// CLUSTER 5: represntative keyword: porter activity, ln p(n)= -48.6 GO:0005215 22 transporter activity F GO:0008565 17 protein transporter activity F GO:0005277 3 acetylcholine transporter activity F GO:0005489 23 electron transporter activity F GO:0005319 3 lipid transporter activity F GO:0005351 4 sugar porter activity F GO:0015077 1 monovalent inorganic cation transporter activity F GO:0005344 3 oxygen transporter activity F GO:0017153 3 sodium:dicarboxylate symporter activity F GO:0005375 4 copper ion transporter activity F GO:0046873 5 metal ion transporter activity F GO:0005487 1 nucleocytoplasmic transporter activity F GO:0008324 2 cation transporter activity F GO:0005338 3 nucleotide-sugar transporter activity F GO:0015198 1 oligopeptide transporter activity F GO:0005478 2 intracellular transporter activity F GO:0005279 1 amino acid-polyamine transporter activity F /// CLUSTER 6: represntative keyword: ase activity, ln p(n)= -93.6 GO:0008026 19 ATP-dependent helicase activity F GO:0004386 25 helicase activity F GO:0016301 8 kinase activity F GO:0016772 2 "transferase activity, transferring phosphorus-containing groups" F GO:0004842 66 ubiquitin-protein ligase activity F GO:0004298 14 threonine endopeptidase activity F GO:0016491 76 oxidoreductase activity F GO:0016705 2 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" F GO:0004364 8 glutathione transferase activity F GO:0004407 3 histone deacetylase activity F GO:0004190 8 aspartic-type endopeptidase activity F GO:0004672 103 protein kinase activity F GO:0004013 1 adenosylhomocysteinase activity F GO:0046933 19 "hydrogen-transporting ATP synthase activity, rotational mechanism" F GO:0046961 19 "hydrogen-transporting ATPase activity, rotational mechanism" F GO:0008417 1 fucosyltransferase activity F GO:0008339 2 MP kinase activity F GO:0004707 6 MAP kinase activity F GO:0004674 85 protein serine/threonine kinase activity F GO:0004527 7 exonuclease activity F GO:0016740 59 transferase activity F GO:0004713 62 protein-tyrosine kinase activity F GO:0004197 15 cysteine-type endopeptidase activity F GO:0008234 9 cysteine-type peptidase activity F GO:0042054 1 histone methyltransferase activity F GO:0008757 11 S-adenosylmethionine-dependent methyltransferase activity F GO:0003899 20 DNA-directed RNA polymerase activity F GO:0004497 17 monooxygenase activity F GO:0004799 1 thymidylate synthase activity F GO:0050080 1 malonyl-CoA decarboxylase activity F GO:0016874 14 ligase activity F GO:0004422 1 hypoxanthine phosphoribosyltransferase activity F GO:0004365 4 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity F GO:0008943 4 glyceraldehyde-3-phosphate dehydrogenase activity F GO:0016615 1 malate dehydrogenase activity F GO:0017111 38 nucleoside-triphosphatase activity F GO:0008553 2 "hydrogen-exporting ATPase activity, phosphorylative mechanism" F GO:0004222 7 metalloendopeptidase activity F GO:0008237 9 metallopeptidase activity F GO:0016787 68 hydrolase activity F GO:0016788 4 "hydrolase activity, acting on ester bonds" F GO:0004000 2 adenosine deaminase activity F GO:0004252 2 serine-type endopeptidase activity F GO:0004178 1 leucyl aminopeptidase activity F GO:0004177 1 aminopeptidase activity F GO:0004003 4 ATP-dependent DNA helicase activity F GO:0016818 2 "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" F GO:0008236 2 serine-type peptidase activity F GO:0008415 8 acyltransferase activity F GO:0016847 2 1-aminocyclopropane-1-carboxylate synthase activity F GO:0016769 7 "transferase activity, transferring nitrogenous groups" F GO:0004838 1 tyrosine transaminase activity F GO:0008483 6 transaminase activity F GO:0016651 5 "oxidoreductase activity, acting on NADH or NADPH" F GO:0004175 13 endopeptidase activity F GO:0008171 3 O-methyltransferase activity F GO:0003995 8 acyl-CoA dehydrogenase activity F GO:0008233 11 peptidase activity F GO:0016887 13 ATPase activity F GO:0016779 6 nucleotidyltransferase activity F GO:0016853 8 isomerase activity F GO:0004494 1 methylmalonyl-CoA mutase activity F GO:0003924 12 GTPase activity F GO:0004420 2 hydroxymethylglutaryl-CoA reductase (NADPH) activity F GO:0042626 4 "ATPase activity, coupled to transmembrane movement of substances" F GO:0004185 4 serine carboxypeptidase activity F GO:0008094 6 DNA-dependent ATPase activity F GO:0047493 1 ceramide cholinephosphotransferase activity F GO:0004623 2 phospholipase A2 activity F GO:0004332 2 fructose-bisphosphate aldolase activity F GO:0016829 3 lyase activity F GO:0004397 1 histidine ammonia-lyase activity F GO:0016211 1 ammonia ligase activity F GO:0008170 3 N-methyltransferase activity F GO:0008378 1 galactosyltransferase activity F GO:0004806 4 triacylglycerol lipase activity F GO:0004550 1 nucleoside diphosphate kinase activity F GO:0016616 4 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" F GO:0004499 1 dimethylaniline monooxygenase (N-oxide-forming) activity F GO:0016303 5 phosphatidylinositol 3-kinase activity F GO:0016773 4 "phosphotransferase activity, alcohol group as acceptor" F GO:0000334 1 "3-hydroxyanthranilate 3,4-dioxygenase activity" F GO:0004357 1 glutamate-cysteine ligase activity F GO:0004742 1 dihydrolipoyllysine-residue acetyltransferase activity F GO:0004500 1 dopamine beta-monooxygenase activity F GO:0008235 2 metalloexopeptidase activity F GO:0004590 1 orotidine-5'-phosphate decarboxylase activity F GO:0004588 1 orotate phosphoribosyltransferase activity F GO:0004126 1 cytidine deaminase activity F GO:0004768 1 stearoyl-CoA 9-desaturase activity F GO:0016717 2 "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water" F GO:0004427 3 inorganic diphosphatase activity F GO:0004743 1 pyruvate kinase activity F GO:0016624 3 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor" F GO:0004428 2 inositol or phosphatidylinositol kinase activity F GO:0004518 6 nuclease activity F GO:0004820 1 glycine-tRNA ligase activity F GO:0004812 11 tRNA ligase activity F GO:0004334 1 fumarylacetoacetase activity F GO:0004449 3 isocitrate dehydrogenase (NAD+) activity F GO:0003980 1 UDP-glucose:glycoprotein glucosyltransferase activity F GO:0008137 3 NADH dehydrogenase (ubiquinone) activity F GO:0000175 3 3'-5'-exoribonuclease activity F GO:0004489 1 methylenetetrahydrofolate reductase (NADPH) activity F GO:0004152 1 dihydroorotate dehydrogenase activity F GO:0004158 1 dihydroorotate oxidase activity F GO:0015036 6 disulfide oxidoreductase activity F GO:0003922 1 GMP synthase (glutamine-hydrolyzing) activity F GO:0016820 5 "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" F GO:0003934 1 GTP cyclohydrolase I activity F GO:0047710 1 bis(5'-adenosyl)-triphosphatase activity F GO:0016810 2 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" F GO:0016844 1 strictosidine synthase activity F GO:0004833 1 "tryptophan 2,3-dioxygenase activity" F GO:0004519 5 endonuclease activity F GO:0016978 1 lipoate-protein ligase B activity F GO:0004749 1 ribose phosphate diphosphokinase activity F GO:0004730 2 pseudouridylate synthase activity F GO:0003978 1 UDP-glucose 4-epimerase activity F GO:0016857 1 "racemase and epimerase activity, acting on carbohydrates and derivatives" F GO:0004721 9 phosphoprotein phosphatase activity F GO:0003989 1 acetyl-CoA carboxylase activity F GO:0004289 5 subtilase activity F GO:0015450 3 protein translocase activity F GO:0004096 2 catalase activity F GO:0004221 4 ubiquitin thiolesterase activity F GO:0004759 4 serine esterase activity F GO:0004555 1 "alpha,alpha-trehalase activity" F GO:0015662 3 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" F GO:0004396 1 hexokinase activity F GO:0004347 1 glucose-6-phosphate isomerase activity F GO:0016831 1 carboxy-lyase activity F GO:0016614 1 "oxidoreductase activity, acting on CH-OH group of donors" F GO:0004367 1 glycerol-3-phosphate dehydrogenase (NAD+) activity F GO:0004176 1 ATP-dependent peptidase activity F GO:0004156 1 dihydropteroate synthase activity F GO:0008705 1 methionine synthase activity F GO:0008898 1 homocysteine S-methyltransferase activity F GO:0008717 1 D-alanyl-D-alanine endopeptidase activity F GO:0004736 1 pyruvate carboxylase activity F GO:0016758 7 "transferase activity, transferring hexosyl groups" F GO:0004618 2 phosphoglycerate kinase activity F GO:0004619 1 phosphoglycerate mutase activity F GO:0004373 1 glycogen (starch) synthase activity F GO:0004356 2 glutamate-ammonia ligase activity F GO:0005078 1 MAP-kinase scaffold activity F GO:0016290 3 palmitoyl-CoA hydrolase activity F GO:0004129 4 cytochrome-c oxidase activity F GO:0016868 1 "intramolecular transferase activity, phosphotransferases" F GO:0003755 2 peptidyl-prolyl cis-trans isomerase activity F GO:0004029 1 aldehyde dehydrogenase (NAD) activity F GO:0016298 3 lipase activity F GO:0004638 1 phosphoribosylaminoimidazole carboxylase activity F GO:0004639 1 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity F GO:0004725 6 protein tyrosine phosphatase activity F GO:0030693 2 caspase activity F GO:0004124 1 cysteine synthase activity F GO:0003854 2 3-beta-hydroxy-delta5-steroid dehydrogenase activity F GO:0004348 3 glucosylceramidase activity F GO:0008408 5 3'-5' exonuclease activity F GO:0008410 1 CoA-transferase activity F GO:0004089 4 carbonate dehydratase activity F GO:0004081 1 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity F GO:0008796 1 bis(5'-nucleosyl)-tetraphosphatase activity F GO:0017057 1 6-phosphogluconolactonase activity F GO:0042132 1 fructose-bisphosphatase activity F GO:0042578 1 phosphoric ester hydrolase activity F GO:0003913 2 DNA photolyase activity F GO:0016836 1 hydro-lyase activity F GO:0003994 1 aconitate hydratase activity F GO:0004794 1 threonine ammonia-lyase activity F GO:0004066 1 asparagine synthase (glutamine-hydrolyzing) activity F GO:0030337 1 DNA polymerase processivity factor activity F GO:0003951 1 NAD+ kinase activity F GO:0008448 1 N-acetylglucosamine-6-phosphate deacetylase activity F GO:0004360 1 glutamine-fructose-6-phosphate transaminase (isomerizing) activity F GO:0004182 2 carboxypeptidase A activity F GO:0004553 4 "hydrolase activity, hydrolyzing O-glycosyl compounds" F GO:0004700 1 atypical protein kinase C activity F GO:0004505 1 phenylalanine 4-monooxygenase activity F GO:0008113 1 protein-methionine-S-oxide reductase activity F GO:0001671 1 ATPase stimulator activity F GO:0008121 1 ubiquinol-cytochrome-c reductase activity F GO:0004594 1 pantothenate kinase activity F GO:0008440 2 inositol trisphosphate 3-kinase activity F GO:0004372 1 glycine hydroxymethyltransferase activity F GO:0008168 4 methyltransferase activity F GO:0004451 1 isocitrate lyase activity F GO:0004474 1 malate synthase activity F GO:0004523 2 ribonuclease H activity F GO:0004342 1 glucosamine-6-phosphate deaminase activity F GO:0003964 1 RNA-directed DNA polymerase activity F GO:0008080 4 N-acetyltransferase activity F GO:0003918 2 DNA topoisomerase (ATP-hydrolyzing) activity F GO:0005391 1 sodium:potassium-exchanging ATPase activity F GO:0004748 2 ribonucleoside-diphosphate reductase activity F GO:0016791 3 phosphoric monoester hydrolase activity F GO:0004363 1 glutathione synthase activity F GO:0008830 1 "dTDP-4-dehydrorhamnose 3,5-epimerase activity" F GO:0004001 1 adenosine kinase activity F GO:0003910 2 DNA ligase (ATP) activity F GO:0004576 1 oligosaccharyl transferase activity F GO:0009003 1 signal peptidase activity F GO:0004829 1 threonine-tRNA ligase activity F GO:0004370 1 glycerol kinase activity F GO:0004411 1 "homogentisate 1,2-dioxygenase activity" F GO:0003874 1 6-pyruvoyltetrahydropterin synthase activity F GO:0004379 1 glycylpeptide N-tetradecanoyltransferase activity F GO:0004437 2 inositol or phosphatidylinositol phosphatase activity F GO:0003950 1 NAD+ ADP-ribosyltransferase activity F GO:0008138 3 protein tyrosine/serine/threonine phosphatase activity F GO:0003896 2 DNA primase activity F GO:0008318 3 protein prenyltransferase activity F GO:0004004 1 ATP-dependent RNA helicase activity F GO:0004823 1 leucine-tRNA ligase activity F GO:0004827 1 proline-tRNA ligase activity F GO:0004540 2 ribonuclease activity F GO:0004143 1 diacylglycerol kinase activity F GO:0003993 2 acid phosphatase activity F GO:0003884 1 D-amino-acid oxidase activity F GO:0004601 3 peroxidase activity F GO:0004525 2 ribonuclease III activity F GO:0004491 1 methylmalonate-semialdehyde dehydrogenase (acylating) activity F GO:0004802 1 transketolase activity F GO:0004362 1 glutathione-disulfide reductase activity F GO:0004719 1 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity F GO:0003876 1 AMP deaminase activity F GO:0019239 1 deaminase activity F GO:0004722 2 protein serine/threonine phosphatase activity F GO:0004814 1 arginine-tRNA ligase activity F GO:0016747 1 "transferase activity, transferring groups other than amino-acyl groups" F GO:0004821 1 histidine-tRNA ligase activity F GO:0004476 2 mannose-6-phosphate isomerase activity F GO:0004822 1 isoleucine-tRNA ligase activity F GO:0003997 1 acyl-CoA oxidase activity F GO:0017017 1 MAP kinase phosphatase activity F GO:0004815 1 aspartate-tRNA ligase activity F GO:0004714 1 transmembrane receptor protein tyrosine kinase activity F GO:0000104 1 succinate dehydrogenase activity F GO:0004807 1 triose-phosphate isomerase activity F GO:0004675 2 transmembrane receptor protein serine/threonine kinase activity F GO:0004733 1 pyridoxamine-phosphate oxidase activity F GO:0004571 1 "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity" F GO:0004053 1 arginase activity F GO:0004070 1 aspartate carbamoyltransferase activity F GO:0004086 1 carbamoyl-phosphate synthase activity F GO:0016812 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides" F GO:0016743 1 carboxyl- and carbamoyltransferase activity F GO:0004652 1 polynucleotide adenylyltransferase activity F GO:0005069 1 transmembrane receptor protein tyrosine kinase docking protein activity F GO:0004435 1 phosphoinositide phospholipase C activity F GO:0004047 2 aminomethyltransferase activity F GO:0005388 1 calcium-transporting ATPase activity F GO:0004579 2 dolichyl-diphosphooligosaccharide-protein glycotransferase activity F GO:0004148 1 dihydrolipoyl dehydrogenase activity F GO:0016757 1 "transferase activity, transferring glycosyl groups" F GO:0004375 1 glycine dehydrogenase (decarboxylating) activity F GO:0004149 1 dihydrolipoyllysine-residue succinyltransferase activity F GO:0004591 1 oxoglutarate dehydrogenase (succinyl-transferring) activity F GO:0004826 3 phenylalanine-tRNA ligase activity F GO:0003887 4 DNA-directed DNA polymerase activity F GO:0004769 1 steroid delta-isomerase activity F GO:0004179 1 membrane alanyl aminopeptidase activity F GO:0004008 1 copper-exporting ATPase activity F GO:0004484 1 mRNA guanylyltransferase activity F GO:0003917 1 DNA topoisomerase type I activity F GO:0008177 1 succinate dehydrogenase (ubiquinone) activity F GO:0016627 1 "oxidoreductase activity, acting on the CH-CH group of donors" F GO:0016706 1 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" F GO:0004064 1 arylesterase activity F GO:0003824 87 catalytic activity F GO:0008642 13 ubiquitin-like activating enzyme activity F GO:0004470 1 malic enzyme activity F GO:0004839 3 ubiquitin activating enzyme activity F GO:0016538 2 cyclin-dependent protein kinase regulator activity F GO:0008603 1 cAMP-dependent protein kinase regulator activity F GO:0005083 3 small GTPase regulator activity F GO:0030235 1 nitric-oxide synthase regulator activity F GO:0008605 1 protein kinase CK2 regulator activity F GO:0015459 1 potassium channel regulator activity F GO:0005246 1 calcium channel regulator activity F GO:0008601 1 protein phosphatase type 2A regulator activity F GO:0005096 3 GTPase activator activity F GO:0008538 1 proteasome activator activity F GO:0005099 1 Ras GTPase activator activity F GO:0004867 9 serine-type endopeptidase inhibitor activity F GO:0004869 2 cysteine protease inhibitor activity F GO:0004857 1 enzyme inhibitor activity F GO:0008073 1 ornithine decarboxylase inhibitor activity F GO:0005093 1 Rab GDP-dissociation inhibitor activity F GO:0004864 1 protein phosphatase inhibitor activity F GO:0005094 1 Rho GDP-dissociation inhibitor activity F /// CLUSTER 7: representative keyword: receptor activity, ln p(n)= -37.6 GO:0004879 36 ligand-dependent nuclear receptor activity F GO:0004888 2 transmembrane receptor activity F GO:0001584 20 rhodopsin-like receptor activity F GO:0004983 4 neuropeptide Y receptor activity F GO:0005057 1 receptor signaling protein activity F GO:0003707 51 steroid hormone receptor activity F GO:0004872 36 receptor activity F GO:0004930 14 G-protein coupled receptor activity F GO:0008158 1 hedgehog receptor activity F GO:0030594 16 neurotransmitter receptor activity F GO:0004890 6 GABA-A receptor activity F GO:0004970 3 ionotropic glutamate receptor activity F GO:0005021 1 vascular endothelial growth factor receptor activity F GO:0005003 1 ephrin receptor activity F GO:0005006 1 epidermal growth factor receptor activity F GO:0005024 2 transforming growth factor beta receptor activity F GO:0008262 1 importin-alpha export receptor activity F GO:0005486 2 t-SNARE activity F /// CLUSTER 8: representative keyword: structural activity, ln p(n)= -3.85 GO:0005198 43 structural molecule activity F GO:0005200 6 structural constituent of cytoskeleton F /// CLUSTER 9: representative keyword: growth factor activity, ln p(n)= -8.43 GO:0008083 1 growth factor activity F /// CLUSTER 10: representative keyword: exchange activity, ln p(n)= -21.1 GO:0005085 6 guanyl-nucleotide exchange factor activity F GO:0000774 1 adenyl-nucleotide exchange factor activity F GO:0005452 1 inorganic anion exchanger activity F GO:0015380 1 anion exchanger activity F /// CLUSTER 11: representative keyword: dimerization activity, ln p(n)= -11.3 GO:0046983 9 protein dimerization activity F GO:0042803 1 protein homodimerization activity F /// CLUSTER 12: representative keyword: motor activity, ln p(n)= -8.92 GO:0003777 20 microtubule motor activity F GO:0003774 19 motor activity F /// CLUSTER 13: representative keyword: transducer activity, ln p(n)= -5.26 GO:0004871 24 signal transducer activity F /// CLUSTER 14: representative keyword: carrier activity, ln p(n)= -26.2 GO:0008320 6 protein carrier activity F GO:0005386 2 carrier activity F GO:0009055 1 electron carrier activity F GO:0008518 1 reduced folate carrier activity F GO:0005498 1 sterol carrier activity F /// CLUSTER 15: representative keyword: nuclear pore, ln p(n)= -7.92 GO:0017056 1 structural constituent of nuclear pore F /// CLUSTER 16: representative keyword: guide activity, ln p(n)= -8.15 GO:0030559 1 rRNA pseudouridylation guide activity F /// CLUSTER 17: representative keyword: channel activity, ln p(n)= -32.2 GO:0005249 12 voltage-gated potassium channel activity F GO:0005262 2 calcium channel activity F GO:0005261 4 cation channel activity F GO:0005216 24 ion channel activity F GO:0005267 8 potassium channel activity F GO:0005230 16 extracellular ligand-gated ion channel activity F GO:0008308 2 voltage-gated ion-selective channel activity F GO:0005272 3 sodium channel activity F GO:0004889 5 nicotinic acetylcholine-activated cation-selective channel activity F GO:0005234 3 glutamate-gated ion channel activity F GO:0005220 1 "inositol 1,4,5-triphosphate-sensitive calcium-release channel activity" F /// CLUSTER 18: representative keyword: pepsin activity,ln p(n)= -6.83 GO:0004194 5 pepsin A activity F /// CLUSTER 19: representative keyword: cuticle, ln p(n)= -4.45 GO:0042302 41 structural constituent of cuticle F /// CLUSTER 20: representative keyword: lysozyme, ln p(n)= -8.15 GO:0003796 2 lysozyme activity F /// CLUSTER 21: representative keyword: hormone activity, ln p(n)= -14.0 GO:0005184 1 neuropeptide hormone activity F GO:0005179 2 hormone activity F /// CLUSTER 22: representative keyword: extracellular matrix, ln p(n)= -8.15 GO:0005201 1 extracellular matrix structural constituent F /// CLUSTER 23: representative keyword: astacin activity, ln p(n)= -8.15 GO:0008533 2 astacin activity F /// CLUSTER 24: representative keyword: neprilysin activity, ln p(n)= -8.84 GO:0004245 1 neprilysin activity F /// CLUSTER 25: representative keyword: muscle, ln p(n)= -8.15 GO:0008307 1 structural constituent of muscle F ///