>1/1-577 ---NTKRQMLSAINGIFDPLGIAAPVLITAKLLFRQ-VIQE-K----------I------ -GWDQ-E-LSQ--SIKTAWSNWTAQAEGLE---T-IAVP--RQF--V------------- -PCKVMI--EPTT-ELHI-FCDASER-AIA-AVAYMR--QKDR-D-------FCHA-G-- FIMA---------------------------KAKI-APM----G---------------- --------------------------------TSIPRLELCAAV-LAV-QLWRIIQQE-- -I------G-DLF---QDV---HF---------HT------------------------- -------------------------------------WFLPFHKV-------THPQ-K-P NKV-RIVFDASAA-C-QG---ISLNNVLLKGPDLL--NSLLGVILRFR---EKEF--AVI ADIHKMFYAFLVRPD--HRRYLK-----F------LWYAD---TQNL---------CDVR VFQMRVHVFGNTPSPAVANYC-LKRT------------A----DEF-GHQF--SPEVASI V-NHN--FYVDDL-LVSFD-S---VHQAIQIVHELQ-AL-LKGA-------NIRLH-KLL SNSR-QI-LQAF-------PSEDLAE--SNVH-----------------------ELFKG -LSSQ-----------------SS--LG-------------------------------- -----LLWDVKSDHLSLRASKFQFVNTKR------------------------------- ----------------------------------------------------------LT DPPFSHVGIDVFGPWE-------------------------------------------- ----------------------------VV--TR-KTRGGVV-NN-----KR-WAV---L -FTCLV--IRAVHIEVIEGMDTSSF-----LNALKRF-IALR-GPIKSIRSDCGTNFVGA TKELN-C-------VSRFGRDP-K----------------------VQ---NFTNTEQIM ----WTFNVPHASHMGGVWERMIGISRKILNAMFL--SH--R--SL----THDVL----- --VTL-----MAEVTAIINNRP--------L--------------V-------------- ----------------------PL-------------TSDPEN--------L-------- ----------- >10/1-581 ---PTRRIILSSIARLYDPIGLVGPVITKAKIFLQK-LCRE-K----------L------ -SWDE-S-LPQ--ALHSDWDMICSSFAMAQ---R-AEFP--RWS--L------------- -SS------QSEV-EIHG-FCDASIE-AYG-ACIYVV--SKGT-RS------E--S-H-- LLCS---------------------------KSRV-APL--K-T---------------- --------------------------------ITVPKLELSGAE-LLA-RLMSEVAQL-- -----------KVYD-GRY---FC---------WC------------------------- ------------------------------SWRPARIYFLPHHCV-------LKED-SST TKL-RVVFDGSAAKT-SG---YSLNDVLMSGPVIQ--PKILHIQLRFR---CHRV--AIT GDICKMYRCVRVFPE--DSYLQC-----IFLDAFDLWRNS---T-QD---------EL-Q VFKLDTVTYGTKPASFLSIRA-MHQL------------A----GDE-QSMFGVP-KGAEI LPLRD--FYVDDL-ISGGD-S---IEEATNIMQQAS-GI-LAKG-------QFRLR-KWC SNFS-EV-LSDVPEEDRESFL------RFD-----------------------------N GSNST-----------------KT--LG-------------------------------- -----LAWDPSTDRLLFSFEGLQS------------------------------------ ----------------------------------------------------------SG CQVFGVTGVDFCGPFY-------------------------------------------- ----------------------------YKPE--VRNK---APV------KC-YVS---V -FICFA--TKAVHLELVKDLSTSAF-----LHALKRFICTRR-K-PQHIWSDNATNFVGA KNELK-E-------LLQLFISD-EH------------------QRALL---EFCAIESIE ----WHFIPPRSPHFGGLWEAAVKTAKHHFYRAVG--S-----SVL----GFDEL----- --RTL-----LCHIGAVINSRP--------LLS------------L-------------- ----------------------SE--------DPA--D-------L-------------- ----------- >100/1-594 ---CTRRGILSVVSSVYDPLGFLAPVILPAKVILQE-LCRK-T----------L------ -GWDD-T-IPS--AFQKQWTHWIVELDKVA---E-FQVN--RCF--K------------- -PVDYGL--PSHA-CLHH-FADACET-GYG-TVSYLK--MLNG-AD------KVHV-S-- FLMG---------------------------KSRV-TPL--K-H---------------- --------------------------------VTIPRLELTAAV-LAV-KMDIMLKKM-- -L------Q-LPL---EDS---VF---------WS------------------------- -------------------------------------WYIPHHGV-------FHPK-K-- GSL-RVVFDCGAA-Y-KG---TSLNDNLLQGPNLT--SSLVGVLLKFR---QEPV--AFM ADIEAMFHQVRVAAE--DVDFLR-----F------LWWPG---GELN---------KEPI TYRMTVHLFGAVSSPSCASFA-LKQT------------A----KDN-EGDF--PLEVIET I-NNN--FYVDDC-LKSVS-C---EEKAISMAKDLT-CL-CQKG-------GFRLT-KWI SNSR-EV-LQSI-------SQENRAKDIQQLD-----------------------LDRDK -LPVE-----------------RA--LG-------------------------------- -----LQWSVDADTFQFKISLKTQPCTRRGILSVVSSVYDPLGFLAPVI----------- ----------------------------------------------------------PD LPPFTNVGVDFFGPIE-------------------------------------------- ----------------------------VK--RG-R-----G-TV-----KR-YGV---L -FTCMA--SRAVHLEMAYSLDTDSC-----INALRRF-ICRR-GQVSSMRSDNGTNFISA ERELK-E-------ALSALNKE-K----------------------IQ---RALLQKGVD ----WSFNPPSSPHFGGVWERLIRLVKQSLCVVLR--Q---Q--TL----DDEAL----- --QTV-----LCEAEAILNDRP--------ISN------------I-------------- ----------------------SN-------------D--------PNDL---------- ----------- >1001/1-540 ---PTKREIVAFSAQIYDPTGLVSPLGVLLKKLISL-LW-TLE----------V------ -KWNE-K-VPA--QLIPMWKGIAAQFSKSI-----YTIP--RQI---------------- ---V-SSYDYKAV-KLVL-FSDASMD-HYA-TAAYLR--FAY-ADG------SVQS-K-- LIYS---------------------------KSRI-KPSKSE------------------ --------------------------------ITIPQMELLGLE-CAT-NAAITLHQE-- -L------H---LDI-EQI---VF---------FC------------------------- ------------------------------------IFYIPHTVV-------IKE-DSLT TKL-RIVLDASSHMK-DE---NSLNDCLHAGPSIL--QPIVGILLRTR---LSKY--MII SDIEKAFHQVRIQSE--FRNVTR-----F------LWIRD---I-TK----EPKGDNV-V TYRFTRLPFGMSCSPFLLAIT-ILLY------------L-------DMAPA--E-IN-NQ I-VEN--LYVDNV-LLTTN-N---AEELRTMYSQLK-NT-FRNM-------HMNLR-EFL CNDE-EV-MESIPKEDK--L---------------------------------------- SSATS-----------------KL--LG-------------------------------- -----HVW---------------------------------------------------- ----------------------------------------------------------QI VAPFAFIGLDYFGPLY-------------------------------------------- ----------------------------YK-SSE-GKG------------KI-WVL---L -VTCIV--TRAIHLEIVQNNTTYSF-----VTSLGRV-FARR-GVPQTILSDNAPTFKLG YSIIN-T-------DIRT----------LANK-----------SATLT---SYLADREID ----IKLITPFSPWQGGIYERLVGLVKNMIVKILG--P-----NVL----SLLEL----- --ESL-----LIESEGILNSRP--------ITP------------N-------------- ----------------------Q------------------------------Q------ ----------- >1003/1-557 ---PTKRNVVGIAAKIYNPLGILSQLTIVFKVFFQR-LCKC-K----------L------ -GWDE-P-LSX--ELDSSWKKLASTLDQGN---Y-VVID--RYL--P------------- -GL-GDQ-EYPFI-QHVG-FCDASLN-AYT-AVVYLR--V-VG-KA------LTSV-S-- ILAS---------------------------KTRV-APL--K-T---------------- --------------------------------VTIPRLQLLSAL-LLA-RLTHLIYGV-- -L------Q-EKFPF-NNP---F-----------P------------------------- ------------------------------DPHAGRIHYLPHHPV-------VRK-DKIA TKV-RIVYDASCSDG-TN---PSXYQCLQVGPRFG--XSILDILIRFR---THTV--ALV GDIEKAFLMVGVERR--DHDALS-----F------LWFDN---P-QSEN------PNI-V KXCFTRVVFGVSSSPFLLNAT-IKYH------------I----EQYIERDP--K-FV-AK F-LHC--IYVDDL-TTGAS-N---VELGYEFYLKAK-LR-LAKA-------GFNHR-KFV FNST-DL-IRRILVNDGQVKE--------------------------------------- AHTSNKLPLEH-----------KV--XG-------------------------------- -----VIL---------------------------------------------------- ----------------------------------------------------------EE KPPFWYTGIDFAGPMY-------------------------------------------- ----------------------------TRE--TL-SS---ESR------KV-WTC---L -FTCCL--TRAVHIELVTEIETVTF-----LCCFQRF-TARR-GFPYRILSDNAKTFKAA NKWLS-T-------ILEH--------------------------PRVK---EFMIGNGNR ----WQFNVEKAPWWGGVFERMIQGMKRLLRKIIG--T-----SKF----TYDEL----- --MTA-----VIEVEAMLNSCP--------LIY------------I-------------- ----------------------PS--------GD-------------------L------ ----------- >1004/1-543 -----KRQLLSLASRLFDPLGCLAPFTIRAKKLFQS-LWLK-G----------L------ -DWDD-Q-LPL--DINRVWCQWKRELETLD---S-VRVP--RAL--M------------- -VSPKDQ--VRRS-ELHV-FGDASET-AFG-AVAYLM--TESM-DG------AKEV-R-- FCLA---------------------------KIRV-APV--R-R---------------- --------------------------------LSLPRLELMAALHVAA-SKSTWNGNX-- -A------F-L-----------------------S------------------------- ------------------------------SGPPGRTWYLPHHAV-------YQH-NQGK TKC-RVVFDGSGEWN-GT----SLNNCLDQGPKLQ--PDLVAVLLRFR---RSRI--ALP ADIEKMYLQVGLRPE--DRDVCR-----F------LWQER---D-CG--------APV-K VYRLTRVGFGLTCSPFLAIQV-VRHH------------A----QRRGNIDA----LT-DR V-LSD--MYVDDL-ATSCD-G---VDEARHLVQRLT-EL-MKTG-------GFVLK-KWA SNDP-DA-LMDLPPEDVSPAD--------------------------------------- EDRLW-----------------KT--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TP SFPFNRVGLDFAGPLY-------------------------------------------- ----------------------------VKD-EHR-P-----AQ------KA-YIC---L -FTCMV--TRAVHLEVVFDMTTISF-----LAALRRF-IARR-GRPSVIHTDNFRTFKQA DSFMR-D-------LLRGNS-----------------------AGKIR---EELAMRQIE ----WKYSTDRAPWCGGYWERLVRSMKNALRKVLG--K-----ALL----RSWEL----- --HTV-----LCELEARINDRP--------LTL------------L-------------- ----------------------SE--------D-----------------PHDC------ ----------- >1006/1-568 ---PTMREVLAFIMSIYDPLGLISNITIQGKILYQE-LHVA-S----------L------ -KWDD-C-IPD--QLLVPWRDWMDLIKSVE---N-LSIP--RCI--T------------- -TEA--I---TEL-ELHV-FVDASED-AFA-ACIYSR--SKTH-YG-------FCI-R-- LLAA---------------------------KSRV-SPI--K-P---------------- --------------------------------ISIPRMELQGAL-LGT-RLMNQVKEK-- -L------R-VKI---TDI---TM---------WS------------------------- ---------------N---------------PGTDRVFYLPHFIV-------TNTN-KIP PKP-RLVFDAAAK-I-KG---VSFNSELLSGPDAT--SSLFGVLLRWR---EGMV--AVT GDIKEMFHQVKIRPE--DQQAQR-----L------LWRDC---D-PS---------KNPD TYVMQVMTFGSTCSPASAQAV-KNTN------------A----ELY-REIY--P-DAVDS I-IDG--HYVDDL-LDSFN-N---AVTGIKVVRQIT-EI-HDHA-------GFHIR-NFA SNSP-EL-MDLI--------PENRRMVANF-K-----------------------SLDEK ESNVE-----------------KV--LG-------------------------------- -----IYWNTLQDSIGYKL----------------------------------------- ----------------------------------------------------------GY VRPFTNCGVDYFGPYK-------------------------------------------- ----------------------------VN--IT-R-----NITD-----KR-WGV---L -FTCMA--SRAVHIEMAPKLDTDSF-----LLCLRNL-QNRR-GKVAKLYSDNGTNFVGA DAVLK-S-------LVKEINAK-M----------------------ES---GTAAEMEIS ----WHFNPPGAPHFGGAWESLVKLAKQAIREMMD--KWKEN-VLP----KPESL----- --QAA-----FIQAEFILNSRP--------LTD------------V-------------- ----------------------PI-------------NC--------------------- ----------- >101/1-583 ---ATKRSILSAISQLFDPLGLVAPIVVRGKMLMQE-LWLT-A----------C------ -AWDD-E-VPD--SLKQKWESFHHQLPKLS---E-FRIQ--RYA--F------------- --QQ-D-SL---V-QLHT-FADASEA-AYG-ACTYAR--SVDS-EG------RVRI-Q-- LLAA---------------------------KTRV-APL-------K------------- ---R----------------------------LSLPKLELCAAV-IAA-QLHVHITEA-- -L-K----M-N-I---ACS---YF---------WS------------------------- ------------------------------EKDDTLSYYLPHHPV-------IKEE-STT TKT-RVVFDGSSKTS-SG---YSLNDALCVGPVVQ--DDLLTLVIRFR---KYPV--ALV ADIAKMYRQVLIHPE--DAPLQR-----I------VWGSN---L-SQ---------PP-S TFELQTVTYGLASSSFLATRT-LQQL------------A----VDE-GNAY--P-LGKPA L-EKS--FYVDDF-IGGAD-S---VPEAIQLREELT-DL-LGRG-------GFPIR-KWT SNKL-EV-LQGLDADCIGTQS--S-V-RFD---------------------------P-- -DETV-----------------KT--LG-------------------------------- -----ICWEPERDQFRFNYHVSQN------------------------------------ ----------------------------------------------------------TP SRPFAVTGVDYAGPVY-------------------------------------------- ----------------------------LKAI--HKRA---SPT------KA-YIC---L -FVCFT--TKAVHLELVSDLSTPAF-----LTALRRF-VARR-GRPSHIHSDNGKNFIGA KNELH-Q-------LYRMLANH-KE------------------VEKIQ---RFCAEDQIT ----WHLNPPKAPHFGGLWEAAVKVAKSQLYRQLG--H-----SHL----SFEDM----- --STI-----LAEIEAAMNSRP--------LVP------------M-------------- ----------------------TE--------DPD--DCSITPAHF-------------- ----------- >1010/1-604 ---PTMRNIYKVVASQYDPLGFLVPYITRAKILIQS-LWAK-Q----------R------ -EWDD-PLLPT--EILKTWHDWQGELQHLS---Q-LTLP--RCY--V------------- -SSQLDS-LNCKR-QVHI-FSDASER-AYG-SVAYLR--SEDL-KG------NVEV-A-- FLTA---------------------------RSRV-APK--R-Q---------------- --------------------------------LSVPRLELCAAL-TGA-QLASLLAKE-- -L------T-LPI---ESF---VL---------WT------------------------- ---------------S---------------KKEEESWFIPHHMV-------SHN----- AKN-RVVFNCSFS-Y-QG---KNLNNLLLPGPALG--SSLLGVLLRFR---EHAV--AFS SDIKGMFHQVRLLPE--DKPLLR-----F------LW-RD---LKRE---------ELPR VYEWQVLPFGTTCSPCCATYA-LQRH------------I----VDH-SQQ---GDNVRHS L-ERC--FYVDNW-LQSVA-T---PDEAKELLDTGM-NL-LAEG-------GFELR-QWA CNFP-NV-IEHL-------SKEARSESSERWL-----------------------NQTES -DPQE-----------------LA--LG-------------------------------- -----LRWMCQSDTLGYQTRLDNCSTPTMRNIYKVVASQYDPLGFL-------------V ----------------------------------------------------------IF KPPFFSTGMDCFGPFT-------------------------------------------- ----------------------------VK--LG-R-----R-SE-----KR-WGI---L -FKCLT--TRAVHIDLLSSLDTDSF-----LMSLRRF-ISRR-GKPSELLSDQGTNFKGG ERELQ-Q-------SFTSMCPT------------------------LQ---KELAKQQIK ----FRFNPPGSPHFGGVWEREIRSVKSALYATVQ--R---Q--SM----TEEVL----- --NTV-----LTEIEGILNSKP--------LGY------------V-------------- ----------------------ST-------------DIADPNPVTPNIL---------- ----------- >1011/1-537 ----TMRSILSNIARMFDPLGLIAPVIIRAKLLMQE-LWLQ-K----------I------ -GWDD-P-VPV--HICNKWKSVTDDWKDLE---S-FKSE--RYV--L------------- --LP-N-SK---I-QFHT-FADASEV-AYG-ACIYAR--CEDQ-QG------RVRV-S-- LLAS---------------------------KSRV-APL-------K------------- ---R----------------------------VTLPRLELCAAV-LGA-HLHHRVRRA-- -M-G----I-D-T---TES---FF---------WS------------------------- -----------------------------------AAYYLPHHPV-------FKAS-STT TKV-RVVFDGSAKTS-TG---FSLNETLRVGPIVQ--DELIDIILRFR---TYKI--AVV ADIAKMYRQIVLHPD--DRRLVR-----I------FFRFS---P-QS---------PI-E LYELNTVTYGLSPSSFLATRT-LLQL------------A----EDE-GADF--P-LASPA L-RHN--FYVDDF-IGGAN-S---VSEARELRQQLS-EL-LSKG-------GFELR-KWT SNCL-GV-LSGLPAEHIGTQS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP SRPFSITGVDYAGPLY-------------------------------------------- ----------------------------LKPA--HKRA---AAA------KC-YLC---V -FVCFS--TKAVHLELVGDLSTAGF-----LAALHRF-TSRR-GLPSDIYSDNGKNFEGA AHELN-E-------LFDMLQNE-QQ------------------QNVIA---SNCSDRGIT ----WHFTPPKAPHFGGLWEAAVKTAKRHLYRQLG--S-----SRL----SYEGY----- --STI-----LQQIEAAMNSRP--------LLP------------M-------------- ----------------------TD--------DPN--D-------L-------------- ----------- >1014/1-529 ---PTKREVLRTLMMIFDPLGFIANLLMYLKVLLQE-IWRT-L----------V------ -GWDD-P-IEE--AQFDKWLTWLKVFPMMC---T-IEVP--RCY--R------------- -SLTSVN---AVA-EIHT-FVDASES-GFA-AVAYLR--YEE--TD------TIEC-A-- LVAA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQAAL-LGV-RSADTISAS-- -L------S-IKI---DKR---YF---------WT------------------------- -----------------------------------RVWYLPIFVV-------VNAN-K-P GKI-RLVWDAAAT-V-HG---VSLNSVLLKGPDQL--TSLLSVLIRFR---EFRV--AIC GDIKEMFHQVRIRKE--DQQCQR-----F------FWKDE---E-E----------AEPS VYVVQVMTFGACCSPSTAQHV-KNSN------------A----KLF-EQDH--P-EAVNA I-IKG--HYVDDM-LVSTE-T---EGETVKLANEVK-EI-HRHA-------GFDIR-NWI SNST-VV-QATL--KH---ASTE---GKNM------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF SPPFTYMGVDYFGPIL-------------------------------------------- ----------------------------VA--VG-R-----H-SE-----KR-WGV---L -ATCLT--TRAIHLQIAHSLTTDSC-----VMAIRNI-MARR-GVPAVIYSDRGTNFRAA SKELK-A-------AIEQLDHD-K----------------------LK---KEFTSTRSQ ----WTFIPPLTPHMGGAWERLIQTVKKNLNVLQP------N-RLP----TDEVL----- --QNA-----MAEVENIVNSRP--------LTD------------I-------------- ----------------------PV-------------DN--------------------- ----------- >1016/1-558 -----KRQILSDIAKLYDPLGFVSPIIVKAKVIMQK-LWCE-K----------V------ -DWDA-C-PPP--QVREEWTDFATSLAQME---P-IYLQ--RNI--Q------------- -VPDDAE----AV-QIVG-FADASSSTGYG-ACLYLR--VIDK-AG------KVTV-S-- LLCS---------------------------KSRI-NPR--KKS---------------- --------------------------------LTVPRLELNAML-LLA-KLTAKMYDT-- -L------K-IKIKI-DDV---IL---------FS------------------------- ---------------------------------------LPHHAV-------LNEA-SKT TRT-RVVFDGSMKTK-NK---VSLNDILLNGPIVQ--RDLFEIITLYR---LGDY--TFN SDIKKMFRNVMVNPE--YTTLQN-----I------LWRDR---L-DE---------PI-R CIRLDTVTYGLKCSSYLATRC-LLEL------------A----NMH-QADL--P-LASFI K-KNC--VYVDDV-LYSDN-D---LTALHEAKQQLK-RL-LSLG-------GFQMH-KWS SNCD-EI-LVDIPFNERQ-------LDEIE---------------------------VQK ENSSI-----------------KA--LG-------------------------------- -----MTI---------------------------------------------------- ----------------------------------------------------------TP SRAFQVVGIDYAGPIQ-------------------------------------------- ----------------------------IKNS--RIRR---ALLT-----KG-YIC---I -FVCFN--TKAIHIELASDLSTETF-----LACFKRF-ISRR-GMPTNIYCDNGGAFKGA ANHLV-D-------LYRLNSSK-DH------------------QTQVQ---NFSNRLGIK ----FNFTPSYSPVFAGLAEAAVKSMKFHLKRVLQ--K-----IVL----TYEQL----- --NTV-----LCQIEAILNSRP--------LMS------------V-------------- ----------------------ST--------DIT--D-------F------SY------ ----------- >102/1-552 ---PTKRNILRCVMSLFDSQGILSHITIQGRMIIQD-TWRK-Q----------T------ -QWDD-E-VDE--SVRIRWLRWTELFKKVG---Q-MRLH--RAY--F------------- -PGFTAA-DIGSV-ELHI-FTDASEE-AYA-CTAYFR--VII--MG------KVYV-T-- LVMA---------------------------KAKV-APL--K-S---------------- --------------------------------LSVPRLELMGAL-LGA-RLAKAVKEY-- -H------T-LPI---CRR---VM---------WT------------------------- ---------------S---------------IDPRRVWYLPLGAV-------RNPK-K-P GKT-RLVWDAAAK-V-GG---VSFNSMLLKGPDLL--TPLALVLCRFR---ERPV--AVC GDLKQMFHQFRIRQQ--DAHSQR-----F------LYREH---P-SQ---------P-VK MFVMDVGTFGATCSPCQAQYI-KNRN------------A----KEH-ETEF--P-EAAKA I-VEK--HYVDDY-LDSFD-T---EAEAIKVALEVK-EV-HARG-------GFEIR-NWH SNSD-AL-LRRV--GE-PRGI----QSKVISI-----------------------D-LEG DA--E-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------AK ERPFSHVGLDYFGPIQ-------------------------------------------- ----------------------------VR--IG-R-----S-CV-----KR-WVA---L -FTCLT--VRAVHLEVAHSLSTESC-----KMAVRRF-VARR-GSPVEIRSDNGTNFQGA SRELR-D-Q------IAT-IGQ-G----------------------LA---ETFTNSNTR ----WVFNPPSAPHFGGSWERLVRSVKVALGS-LC--G---D-RNP----DDETL----- --LTV-----LAEAESIINSRP--------LTS------------I-------------- ----------------------PL-------------ES--------------------- ----------- >1022/1-609 ---HTRRGLLSLVSSIYDPLGFLAPVILPAKLILQG-LCRN-Q----------C------ -DWDE-E-LTE--NILKDWMNWISSLKALD---S-FGVN--RCV--K------------- -SQPLKN--PIFA-QLHH-FSDASEN-AYG-TVSYLT--LHSE-NK------EAQS-T-- LILA---------------------------KARV-APL--K-S---------------- --------------------------------QTIPRMELIAAT-VAV-KMDMLLRRE-- -L------D-LEL---SDS---VF---------WT------------------------- ---------------E---------------PVQGRTWYLPHHGV-------RHPT-K-- QNL-RVVFDCGAS-Y-QG---VSLNNELLQGPDLT--SSLVGVLLRFR---EETV--AIK ADVEAMFHQVRVNNS--DTDLLR-----F------VWWPD---GDYS---------QELC DHKMLVHIFGATSSPSVANFA-LRQC------------A----TDF-ENEF--TQEVSNT V-KNN--FYVDDC-LKSTS-D---EDTAVNLCKDLR-SM-LKKG-------GFRLT-KWS SNSR-TV-LNAI-------SAEERAQGYQDLD-----------------------LNKDN -LPVE-----------------RA--LG-------------------------------- -----IQWCTETDQFKFKINLKKRPHTRRGLLSLVSSIYDPLGFLAPVI----------- ----------------------------------------------------------PD DPPFTRVGVDYFGPFL-------------------------------------------- ----------------------------VR--RG-R-----T-QV-----KR-YGV---I -FTCLA--IRAVHLEVAASLDTNAC-----LNAIRRF-IARR-GQVTEMYSDNGTNLRSA DSELK-R-------SIKEWNIN-K----------------------IT---KDLQQKNIQ ----WHFNPPSGSHHGGSWERLIRSVRKVLNTTVN--E---Q--IL----DEDSF----- --HTL-----LCEAESIINSRP--------ITK------------A-------------- ----------------------ST-------------DLNDLEALTPNHL---------- ----------- >1024/1-524 ----TLRNIYKVLARQYDPLGFILPYTTRAKLIVQR-MWDK-P----------R------ -DWDD-PHIPQ--DLQEAWKEWESELHLLP---H-ISFP--RPY--A------------- -STPHSQ-MIVSR-QIHV-FSDASEK-AYG-AVSYLR--TEDG-QG------QVSL-A-- FLAA---------------------------RSRV-APR--R-Q---------------- --------------------------------HSIPRLELCGAL-TAA-QLAKTIARE-- -L------T-VVI---DQT---IL---------WS------------------------- ----------------------------------EESWYIPHHLV-------SHN----- GKN-RLVFNCSYQ-H-QG---RNLNDTLLPGPTLG--ASLLGVLLRFR---QHAV--AVS GDIKSMFQQVQLLPR--DRPLLR-----F------IW-RD---MRRM---------EPPD IYEWQVLPFGTACSPCCATFA-LQLH------------A----RTH-SKE---GDGVRHS V-EQC--FYVDNC-LQSVD-T---ADEARKLVDQIR-EV-LASG-------GFEIR-QWA CNLP-DV-IKHL-------PAEA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LH KPAFYSTGVDCFGPFQ-------------------------------------------- ----------------------------IR--IG-R-----R-SE-----KR-WGI---I -YKCLT--TRAVHLDLLHNMDTDSF-----LMSLRRF-IARR-GTPAELLSDQGTNFKGG EKELR-D-------SFNSMSLD------------------------LQ---QLLAKQKID ----FRFNPLAAPHFGGTLEREIKSVKSALHTVMG--V---Q--SV----SEEVL----- --YTV-----LLEVEAILNTKP--------LGY------------T-------------- ----------------------SS-------------SV--------------------- ----------- >103/1-566 ----TRRTVLSDTARLYDPLGLIGPVVVLAKLFVQT-LWRT-S----------K------ -NWDD-P-LDE--SEQQHWLEFRSSLEELA---T-ISIP--RWA--A------------- --PASV-LV--SI-EVHG-FCDASEK-AYG-ACLYLR--TVST-DG------TIAV-R-- LLAA---------------------------KSKV-APL--G-DSKK------------- ---QKR--------------------------ICLPRLELSSAL-LLS-HLYHKVQES-- -T-A----L---N---VKA---IF---------WT------------------------- ------------------------------TPMNCPSYYLPHHGV-------EKAE-STT TKL-RVVFDASCSTD-SG---ISLNQALMVGPVVQ--DDLLAIILRFR---MKRF--VII ADIEKMFRQIRVHPS--DYPLQR-----I------LWRSS---P-TQ---------PL-R TFELTTVTYGTASAPYLATKC-LQQL------------S----KDG-ADNF--P-LASAI L-AED--FYMDDM-LTGVD-D---EQEGEEACQQLL-QL-MKSA-------GLSLR-KWT SNSP-AI-LSKIPAELRDERT--S-L-SLD---------------------------S-- SSAPI-----------------KT--LG-------------------------------- -----LQW---------------------------------------------------- ----------------------------------------------------------IP TLPFLNTGVDLCGPFM-------------------------------------------- ----------------------------YRRT---RKA---PPI------KC-FVA---I -FVCLV--TKAIHVELVYDLSTAAF-----MAALHRF-IARR-GKPNLIECDNATNFRGT ARELK-E-------LAKQFRSQ-QH------------------QGEIV---NHCADEGIT ----FKFIPPRSPNFGGLWEAAVKSFKLHFRRTVG--N-----SIL----SQDEF----- --VTL-----LTRIEACLNSRP--------LTP------------L-------------- ----------------------ST--------DPN--D-------L-------------- ----------- >1032/1-542 ---PTKRQVASRLAETFDPTGITTPILVALKRLMQL-CW-TDN----------L------ -NWND-P-LTE--KLLRIYRKIQEGIRHSA-----ITVP--RQV---------------- ---T-TNYGNSKL-RLMV-FSDASLD-MMA-ACVYTH--YTY-ESG------PPVV-S-- LLCS---------------------------KNKI-KPANNE-N---------------- --------------------------------LTIPKMELTAII-MGT-NLAIAAKKE-- -I------P---IPV-VEI---CF---------LT------------------------- ---------------------------------------IPHRAV-------IKM-SSAT TKV-RIVYDASSHKR-YE---LSLNDCVFPGPCIL--QSIFGILLRAR---LFLY--IIL ADIEKAFHQVQMKEE--FRDVTR-----F------LWLKD---I-TK----PVTPDNI-Q ILHFKKIPFGLASSPFLLNAT-ILLF------------L------QLIHMY--X-MK-XQ R-RIS--MLTMHC-TTQTK-NQIFQRKIRYFVKASK-KI-FEDM-------SMNLR-EFA VNDA-EE-MKRIPEKDR--A---------------------------------------- EDTTI-----------------KI--LG-------------------------------- -----YSW---------------------------------------------------- ----------------------------------------------------------EP SFPFEKAGLDYLGPIQ-------------------------------------------- ----------------------------YIKEDG-SIG------------SC-YVL---V -YTCLV--TRGARLELVPDGTTERY-----MEALRIV-FSRS-GTPKVIYSDNAATFRLG EKLIN-E-------DIRT----------HE-P-----------SESLT---SFLADREID ----FIDITPLSPWQGGVYERIVGLVKHQLQKELG--K-----TLL----DFHSL----- --RCV-----LAGTETMINSRP--------LTP------------H-------------- ----------------------MR------------------------------------ ----------- >1035/1-546 ---PTKREALRMLMLMYDPCGLIAHFLMYLKVLLQE-IWRS-G----------I------ -GWND-K-IGE--KEFEKWLLWIKVLPGVR---N-VRVQ--RCY--R------------- -KHTSIN---AEV-QLHT-FVDASEN-GFA-AVVYLR--FQE--GE------NIEC-A-- IVAA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQAAV-LGV-RLANTVQRS-- -L------N-IKV---SQR---FF---------HT------------------------- -----------------------------------RVWFLPVFPV-------VNPN-K-P AKT-RLVWDAAAK-A-HD---VSLNSVLLKGPDYL--TSLLSVLIQFR---EHRI--AVC GDLREMYHQVLMRDE--DQHCQR-----F------FWGRK---D-GT---------PEPN TYVMQVMTFGACCSPSTAQYV-KNQH------------A----KQY-ENEF--P-AAVRA I-VDQ--HYVDDM-LVSIE-T---EEEAATLAHDVK-WI-HKQG-------GFEMR-NWL SNSK-TV-LATL--QE---SPQA---EKNFNV-----------------------SDG-L PT--E-----------------KI--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TRPFTHMGVDYFGPVT-------------------------------------------- ----------------------------VS--IG-R-----R-TE-----KR-WGV---L -ATCLT--TRAIHLQVAYSLSTDSC-----IMALRNI-FSRR-GTPSVIYSDRGTNFQGT AKMVE-E-------VVRKIDQD-K----------------------LV---AEFTSNHTE ----WKFNPPASPHMGGAWERLVRTVKQNLNKVLG------T-RVV----SAEVL----- --ENA-----LNEVENIVNSRP--------LTN------------I-------------- ----------------------PV-------------DG--------------------- ----------- >1038/1-563 ---MTRRGILSSVSSIYDPLRFAAPFLFRGKKIVQV-LCKA-A----------L------ -RWDD-P-IPE--VMQDQWRKWVSELPLLE---K-IQIP--RCF--K------------- -SKTMGE--IKKA-ELHH-LSDANSE-GYG-QCSYLR--LIDT-DD------KVNC-S-- LVMV---------------------------KARA-APL--K-S---------------- --------------------------------VTLPRLELTAAL-TSV-KVSRMLGSE-- -L------R-YDG---VEE---VF---------WT------------------------- ---------------P---------------PEYERAWYIPHHGV-------XNPK-K-K DKI-RVVFDCSAE-F-QG---HSLNRQLLQGPDLT--NSMVGVLCRFR---QERV--AVA CDIEGMFHQVRVNEE--YRDFLR-----F------LWWEG---GDTK---------REPV EYRMRVHLFGATSSPGCANTA-LRQA------------A----QEG-ESLH--GSTAATF V-KEN--FXVDDG-LASTP-T---AEEAVTLLKKGA-EL-CKDG-------XFRLH-KFL SNER-KV-IEAI-------KDEDRAKNIQNLD-----------------------LDSDA -LPPE-----------------RV--LG-------------------------------- -----VEW---------------------------------------------------- ----------------------------------------------------------TP APPFTYCAVDYFGPFY-------------------------------------------- ----------------------------VK--EG-R-----K-EL-----KR-NGV---L -FTCLA--SREVHIEIAHNLETDSY-----INALRRF-ICRR-GPIRQIRSDQGTNFVGA KRELN-D-------ALNKMDKK-R----------------------VK---IEMLKLNCD -WFETKFNVPSASHMGGVWERQIRMVRSVLCALLE--K---NGSQL----NGEAL----- --RTF-----MCEAEAVVNSRP--------LTT------------A-------------- ----------------------------------------------PTSA---------- ----------- >1039/1-552 ---WTMRKILRVLNSIFDPLGLLYPASLKARLFFQS-LWE-LK----------L------ -KWDT-P-LPE--EKQLEWTAIATEWED-A---I-IELP--RSL--C------------- ----I-KQNHS-S-QIHI-FCDASLV-CYA-TAVYLQ--TTSEKE--------SKI-N-- LVFA---------------------------RSRL-AP--------INSK---------- --------------------------------ITIPKLELLGIV-IGV-RAGNFIKKE-- -M------G-LKEA---KT---IL---------WT------------------------- -------------------------------------HFIPHQAV-------YRQ-DKK- -KL-RIVFDCSAHIK-GH---PSLNDTLYRGPVLL--PKVAAVLLRWR---QAKI--VIA CDIKAAFLMLELHKE--DRDLTR-----F------LWLRD---L-NK----PPTQANI-K ILRFRRVLFGAVSSPFLLGAT-VIHH------------LRNSAIAKKYPS-----IA-KE V-ENS--IYMDNI-LLTAN-S---EEEGKNKINIIR-EI-FLDA-------NMELR-EFL ANNE-SV-LSELEETAK--I---------------------------------------- -APHK-----------------KF--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------QK SPVFANIGLDYLGPTL-------------------------------------------- ----------------------------VTMP-DNSKH------------KL-WVL---L -ITCLA--TRAVWLDSVLDLSAKTF-----LNALRRF-IAKR-GRPNYILSDNATNFHLT AKTLD-E--------------I-WG---KIIN-----------SSETM---NFAAKEKIN ----WKFIVPLSCWEGGAYERLCGLAKNAFKRAIG--K-----RIL----QLDEM----- --NTV-----ISEVEGILNSRP--------LVP------------M-------------- ----------------------DD--------NPD--S-------VRTLRPFDF------ ----------- >104/1-554 ---TTKRIIYSEVAKLFDPLGLFAPVIVIAKLLVQQ-LWRT-S----------A------ -GWDD-P-IDD--EIQDRWSTLQSTLPELG---R-IHVP--RCV--T------------- --FP-D-TI--AH-EVHG-FADASNV-AYG-ACIYLR--SIFT-DG------SACL-R-- LLCS---------------------------KSKV-APL-------H------------- ---E----------------------------LSIPRKELCAAL-LLV-NLVVQVIKT-- -L-Q----M-P-F---REV---VL---------WS------------------------- ---------------------------------------LPHHAV-------LRPS-SST TKC-RVVFDASAKSEPSK---MSLNDVLQVGPVVQ--NGIFQITLRFR---KHAY--AFS ADISKMYRQVLVAQP--DRRFLR-----I------FWRSD---R-SH---------PM-K VLELNTVTYGTACAPYQATRC-LVQL------------A----KDD-GPEF--P-IGAQI L-TDD--FYVDDT-LSGAN-T---IEQAIECQCQLK-AL-LAKG-------GFHIH-KWC SNSE-EF-IQRIPIEDREQQV------PLN---------------------------EYG PNKVI-----------------KV--LG-------------------------------- -----ILW---------------------------------------------------- ----------------------------------------------------------VP SPPFAVTGVDYAGPFL-------------------------------------------- ----------------------------VK--QGTHRP---KIV------KA-YVA---V -FVCMA--TKAVHLEVVSDLSTDAF-----LASLKRF-ISRR-GMVQEIHSDNATNFHGA NNELH-E-------LYRQFQDQ-RT------------------VDEIQ---HFCQVREIQ ----WHFIPPDAPEFGGLWEATVKSTKTHLKRVVG--N-----VKL----TFEEL----- --ATV-----MAEIEAILNSRP--------LFS------------I-------------- ----------------------SN--------DPS--D-------P-------------- ----------- >1041/1-522 ---TTKQKMISDINSIYDILGWSSPVNITAKLIFSE-VCLL-Q----------L------ -HWDE-R-VPE--GIHKKWWMWIKSLQLAP---T-IIIP--RCV--F------------- ----TDT--PTSF-EIHG-FADASKV-ALC-AAVYVV--ACRD-SK------PVSQ-Q-- XLVA---------------------------KFRI-APK--D------------------ --------------------------------RSIPRLELAAAH-TLA-KLQNNVSKA-- -L------AAFPI---TA---------------WN------------------------- ---------------------------------------VPHQAV-------IRE-KAET TKM-RIVYDCSAKAN-TK--SPSLNDCLETGPSLQ--PLLFDIMIRNR---MRKY--CIR GDIQKAFLQIRVHEQ--DRDAMR-----I------LWYNN---L---QD------RQL-M EYRFTRVIFGATSSPYILGVT-LQKH------------I----ENYTENYP--I-TV-QT L-LDD--TYVDDI-QGGGE-T---ERDVAVFKEKST-KI-LSEG-------GFSLH-KWH SNIT-HL-SSK------------------------------------------------- ---------NNI----------KH--EG-------------------------------- -----TDN---------------------------------------------------- ----------------------------------------------------------EF TEPFDVTGVDFAGPLH-------------------------------------------- ----------------------------YKL--G--KS---ETN------KS-YIA---L -FTCAT--TRAVHLKLCRDMSTIEF-----KRGLKEF-VARR-GSPSCMVSDNAKTFVAT KMWLT-K-------LQND--------------------------EDIF---NYLTTKGIE ----WRFNLSRSPWWGGFFERLIGITKRALSKTIG--R-----ALL----TFEEL----- --EEV-----LLDVEVFMNNRP--------LCY------------M-------------- ----------------------EE--------D--------------------L------ ----------- >1044/1-571 ---PTKRIALSIIMSLFDPLGLLAPYLVHGRILVQD-LWRA-G----------M------ -NWDD-P-MGD--AEFTKWKRWIELISKIG---K-LKIP--RHY--F------------- -AGASIP-IEQKL-QLHI-FCDASES-GYG-CVAYFR--AELE-DG-------IHC-T-- LIMA---------------------------KSKV-APL--K-C---------------- --------------------------------QSIPRLELQAAL-LGA-RMMNSICEN-- -H------T-ITF---SRK---FI---------HT------------------------- -------------------------------------WYLPINVV-------AHPR-K-P EKK-RLVWDAAAR-V-DG---ISLNSQLLKGPDLL--ALLPGVLCKFR---QGCI--AFG GDIEKMFHQIRIREN--DKHAQR-----F------LFRFD---A-NS---------E-PD VYIMDVATFGAACSPCSAQFI-MQRN------------A----EEH-RSAW--P---AAA I-MKS--TYMDDY-LDSSD-T---VAEASSLALQVR-HI-HANA-------GFNMR-NWM SNHQ-EV-LEAL--GE-----SHDRREMNI-------------------------ECDTE PE--H-----------------RV--LG-------------------------------- -----VKW---------------------------------------------------- ----------------------------------------------------------PH VRPFSRVGIDYLGPIE-------------------------------------------- ----------------------------VS--VG-R-----T-KV-----KR-YVA---V -FTCLV--VRAIHLELVYDLSANAC-----IMAIRRF-VCRR-GPPLEIFSDNGTNFVGA SNELK-K-Q------LRE-INN-D----------------------CA---ETFTNTRTA ----WQFNPPAAPHMGGVWERLVRSVKEALTV-LQ--D---G-RKL----TDEIL----- --TTV-----LVESENLINSRP--------LTY------------V----PQSTSDNEAL TPNHFLLGSSSGSQDQAKT---PT-------------EL--------------------- ----------- >1048/1-544 -----KRLVLKQLASVFDPLGLASPSLLPAKLFFQS-LWE-KP----------R------ -EWDN-I-LTE--EEANKWLNITEKWKV-S---P-IEIK--RKI--I------------- ------GKIGD-Y-QLHV-FCDASKD-AYA-SCVYMR--CLINGK--------MSV-N-- ILYA---------------------------RNRL-RPK--K----MS------------ --------------------------------VSIPRMELLGVL-IAT-RAIKFVENQ-- -I------G-LKIS---EK---YL---------WC------------------------- ------------------------------RNKGSIEHFLPHHPV-------ITT--K-- -KV-RIVYDASAKIR-GG---KSLNELLYRGPIIM--PELAGMLIRFR---LPEI--AIW ADIEKAFHCLELDPE--DREVLK-----L------IWLKD---V-RK----PISSENI-K YLRFSKVPFGVISSPFLLSAT-VRHH------------L------ESMDD---P-IA-KM V-KNN--SYVDNI-LIGVD-T---KEESYEAYIKLK-SI-FKTA-------QMNLR-EFI SNNL-EF-NEDLPMEDR--L---------------------------------------- DKSKP-----------------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------RK SRAFEAIGVDYLGPSL-------------------------------------------- ----------------------------YKI--EDGKA------------KF-WIV---L -FTCMT--TRAVHLEIALELSALEF-----MHCLRRF-IAIR-GCPKNIISDNATQFKVG SELVG-A-------KLVGKW-I-EK---SKNE-----------EKRLN---NFLINKGIE ----WCFIPSLSPWAGGVYERLVKLVKDSFKRTLG--G-----IIL----NLEEL----- --RTF-----IKEVEFSINCRP--------ITF------------V-------------- ----------------------SG--------E-I------------------------- ----------- >105/1-547 ---PTKREVLRLVMSLFDPLGLIASFVVEGKVIIQE-IWRA-N----------V------ -GWDE-H-IPS--EMLPRWQQWLEVLRLLD---K-VKIP--RCY--F------------- -PGYSKE-AYETL-ELHI-FVDASES-AFA-TAAYFR--IVD--KG------EVRC-S-- LVGA---------------------------KTKV-APL--K-L---------------- --------------------------------LSIPRLELQAAT-IGT-RLMKTIVDN-- -H------T-IPV---KRR---VM---------WS------------------------- -----------------------------------RVWYLPLGIV-------VNPR-K-P DKL-RVVWDAAAT-V-QG---VSFNSVLLKGPDLL--VPLQTVLCRYR---QKEI--AIS ADIMEMFHQVQIRQE--DRQAQR-----F------LWRDN---P-AE---------P-AK VFVMDVAIFGSTCSPCSTQFA-KNIN------------A----EEH-AEEF--P-KAAVA I-KEN--HYVDDY-LDSVD-S---VDEAVQLASDVK-TV-HERA-------GFQIR-HWL SNSP-EV-LRQI--GD-QNTQ----AVKSFVM-----------------------D-KGS QQ--E-----------------RI--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PY VRAFTFVGLDYFGPLN-------------------------------------------- ----------------------------VR--VG-R-----A-SV-----KR-WVA---L -FTCLT--TRAVHLEVAASLSTDSC-----KQAIRRF-IARR-GAPQEVYSDQGTNFQGV SSELS-K-Q------IQS-INA-T----------------------LA---STFTNYRTQ ----WKFNPPYAPHMGGVWERLVRSVKRGLSC-LL--T---D-RNP----DDEAL----- --STV-----LAEVESLVNSRP--------LTY------------L-------------- ----------------------PL-------------ES--------------------- ----------- >1051/1-559 ---FTRRGVLSTVSSFYDPCGFLSPVMLRGKQILQE-LCRS-K----------L------ -DWDS-P-IPE--DLRPRWERWLQEVLELE---N-LQIP--RCY--K------------- -PRDFGE--IKAV-ELHH-FSDASQE-GYG-QCSYIR--LVNT-QD------KVHC-S-- FVIG---------------------------KSRV-TPL--K-Q---------------- --------------------------------VSIPRLELTAAT-VSA-RMSGFLNQE-- -L------K-YDS---FKE---FF---------WT------------------------- -------------------------------------NYIPHTGV-------YHPR-K-P NKI-RVVFDCSAT-Y-QG---VSLNDMLLQGPNTM--NSLLGVLCRFR---KEAV--AVA ADVKSMFHQFYAAAE--DRDLLR-----F------LWWED---GNPE---------NAVV EYRMKVHLFGAASSPGVATFG-LRRA------------A----DDG-EEEY--GAPAANY I-RTD--FYVDDG-LRSEP-D---VASAIQLLKNSQ-AI-CAKA-------GLTLH-KIV SNER-EV-QESF-------TKKEGLTDKKELG-----------------------LARSP -STLE-----------------RV--LG-------------------------------- -----VVW---------------------------------------------------- ----------------------------------------------------------EP SAPFTYCAVDYFGPFL-------------------------------------------- ----------------------------LK--EK-R-----S-EV-----KR-YGV---L -FTCMS--SRSIHLETANSLSSSSF-----INALRRF-MNRR-GTVRQLRSDQGTTFIGA RNELK-Q-------ALQEMDQK-H----------------------VQ---EYLLENGVE -WIPFKFNVPHSSHMGGVWERQIQTVRRALDTLLA--K---AGSQL----DDESF----- --RTF-----MTEAECIVNSRP--------LTT------------N-------------- ----------------------NL--------S----DAEA------------------- ----------- >1056/1-537 ---ATRRGILSTVASLYDPLGLNAPFLLRGKLVLQE-MCRN-G----------T------ -GWDE-P-LLQ--ELQPRWEQWKDDLANLE---K-FNIP--RCY--V------------- -PASFGK--VIKR-ELHH-FSDACNC-GYG-QCSYLR--FIND-VG------NIHC-A-- LVIG---------------------------KSRV-API--K-V---------------- --------------------------------QTIPRLELTAAV-VSV-VISNMLKQE-- -L------E-YKD---IGE---HF---------WT------------------------- -------------------------------------WYIPHHGV-------YHSK-K-P DKL-RVVFDCSAK-Y-QG---TSLNDHLLQGPDLI--NNLMGILVRFR---QHPI--ALM CDVEMMFHQFHVDEA--DRNYLR-----F------LWWKK---GELG---------SYPQ EYRMKVHLFSATSSPGCANYG-LKHL------------A----KEN-EHLY--PLGS-KF I-TTD--FYVDDG-VTRVI-S---TEEAIQIATEAR-QL-CALG-------GLRLH-KFI TNDR-VV-LDSI-------P-----------------------------------I---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DP SPPFTYCGMDCFGPFF-------------------------------------------- ----------------------------TK--QG-R-----K-DH-----KR-YGL---L -FTCFS--SRAIHIEMLDDMSTDAF-----INGLRCF-IALR-GAVRQIKCDQGTNFVGA KNELK-N-------ALKEVDSD-R----------------------LT---VFLAKKQCD ----FVLNAPHSRHTGGVWERQIRTVRNVLRSTLS--L---SSGRL----DDASL----- --RTF-----FYEAMAIVNSRP--------LSV------------E-------------- ----------------------NL--------N----DPNSLAPLTPNNL---------- ----------- >1059/1-567 ---FTRRGVLSTINSLFDPLGIAAPVTIQGKFILRD-LTLG-S----------I------ -DWDS-P-LPQ--TMEETWVAWRNSLQELR---H-LQIP--RTY--S------------- -KQSPSV--AACR-ELCV-FSDASIK-AIA-AVAYLK--LSYP-ER------SNDV-S-- FVMG---------------------------KVKL-SPL--P-E---------------- --------------------------------HTIPRLELCAAV-LAV-EVVDLISSE-- -M------D-MDL---DVI---TF---------YT------------------------- -------------------------------------WYLPIFGV-------YHPK-K-P GQI-RVVFDSSSQ-Y-NG---VSLNDMLLTGPDLN--NSLLGVLLRFR---KESV--AIT ADIQQMFYCFLVKEE--DRNFLR-----F------LWFRD---NDPS---------KDIV EYRMTVHVFGNSPSPAVAIYG-LRKA------------A----HQE-GKER--DPEVQQF V-ERD--FYVDDG-LKSLP-T---VEATVSLLKRTQ-TV-LARS-------NVRLH-KIA SNKR-EV-MEAF-------PSQDYASDLKDLD-----------------------LEKDN -LPMQ-----------------RS--LG-------------------------------- -----LNWDLKQDCFVFTV----------------------------------------- ----------------------------------------------------------CT DPPFTNIGLDVFGPWS-------------------------------------------- ----------------------------IY--TR-RTRGGLA-HD-----KR-WAV---I -FTCLN--VRAVHIEVIESLDTSSF-----INALRRF-FALR-GPVKEIRSDRGTNFIGA CKELQ-I-------PSN-IDEK-S----------------------VQ---KYLAEHGCS ----WIFNPPHASHMGGCWERMIGMARKILDSMFL--QL--GHMKI----THEVL----- --TTF-----MAEVTAIINARP--------L--------------V-------------- ----------------------PV-------------ST--------------------- ----------- >106/1-540 ---HTKRRVLSIVMSIFDPLGLLGFFNIRAKIILQN-IWRS-G----------V------ -SWDD-T-IKD--SDENDWRAWQSSLSKLS---N-LRIP--RYM--Y------------- -GSKAAE----NV-QLHI-FVDASLD-AYA-AVAYLR--VER--GG------EIRC-S-- LVAS---------------------------KNRV-APL--K-P---------------- --------------------------------ISVPRMELMAAI-LGL-RLSKFLEAE-- -L------S-IRI---ERR---IF---------WT------------------------- -----------------------------------CSWYIPVFVV-------TNPN-K-- KKK-RLVWDAAAQ-V-NG---LSLNDTLMKGPDLL--VSLPGVLLRFR---ERPV--AVT GDIREMFHQIKVRAS--DQSVQK-----F------LWRNG---E-ND---------RPPD TFVMQVMTFGASCSPSLANFI-LKKN------------A----EQF-GDNC--P-DAIRT I-CQN--TFVDDW-LESVD-T---DDEMIQLANNVK-MI-HAKG-------GFEMR-NWL SNSK-SV-LQSL--NS---SPAA--SPKYLG-------------------------SE-Q -E--L-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------PY TLPFTYTGVDYFGPIE-------------------------------------------- ----------------------------VA--VG-R-----R-RE-----KR-WGV---L -FTCMT--VRAVHLELVPSLSTDSF-----LLALKLF-TARR-GVPIKMLSDNGTNFRGA SRVLA-K-------EIERISTL-D----------------------VE---SKY--PQMT ----FAFIPPGSPHMGGAWERMVRSTKSILSEILS------N-VVL----REEVL----- --RGA-----FADVENTLNSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >1060/1-567 ---PTKRMILSQIASLFDPLGLLAPVIVKAKLVMQR-MWEL-K----------V------ -AWDA-N-PPG--ELTNKWLNLVQSFSLLN---S-FQIP--RHV--I------------- --NVKN-WS--RL-YLHG-YCDASDV-AMG-ACVYIR--AVND-NG------DTSS-H-- LLCA---------------------------KSKL-API--G-NGK-------------- --------------------------------TTIPRLELCAAV-ILA-RLITNVRSA-- -L-S----T-TSF---YEV---RA---------FS------------------------- ------------------------------------SVYLPHHCV-------VKET-SST TKC-RVVFDASAKTT-SG---LSLNDVLMCGPTIQ--DSLINILIRFR---MPPI--VLV GDVKQMYRMIWVHED--DRDCLK-----I------LWRWN---K-EE---------AI-K EYRLNTVTFGTKCASFLATRC-VQQL------------M----ESH-RVQY--P-VAVEK V-EKG--IYVDDV-LTGAE-T---EEEARTLREQLT-EM-FKDG-------GFHLR-KWA SNCP-AV-LEGVPEADLEVKI------NIE----------------------------ES ESNVV-----------------KA--LG-------------------------------- -----MQW---------------------------------------------------- ----------------------------------------------------------KP LPPFTITGVDYAGPVS-------------------------------------------- ----------------------------IIGR--KCRA---AVPS-----KG-YIA---L -FVCLG--TRAVHIEAVSDLSAPAF-----LAAFTRF-YCRY-GVPNKMYSDNASNFRAS AKILR-E-------LYQQISTT-EH------------------SNEVS---DYLADKGVE ----WLFIPARSPHQGGLWEAAIKVAKRLLSRIGD--N------XY----TFEEL----- --STI-----LSQVAACMNTRP--------ISA------------I-------------- ----------------------ST--------DPT--D-------PQPLTPAHF------ ----------- >1064/1-592 ---FTRRGVLSAINSLFDLLGFVAPIIVQGKALVRE-LSTE-S----------C------ -DWDA-P-LPT--EKETKWTSWKDSLIELE---Q-FQIP--RTY--L------------- -PISLVS--TQNR-ELCV-FSDASTT-AIS-AVAYLR--AVDD-QG------HIHV-G-- FCMG---------------------------KSKL-APK--L-C---------------- --------------------------------HTVPRLELCAAV-LAV-ELANMLLDE-- -L------D-ITI---HAV---KF---------YT------------------------- -------------------------------------WYLPIFGV-------YHPR-K-P GQI-RAVFDSSAK-H-DG---ISLNDVLLTGPDLN--NSLLGVLTRFR---KEHV--AVA ADIEQMFYCFKVCEE--HRDFLR-----F------LWFKD---NDPT---------KEVM EFRMTVHVFGNSPSPAVAIYG-LRRT------------A----LQG-LGEY--SLEASQF V-LKN--FYVDDG-LTSFP-T---TDNAIRVLKETK-EM-LAVS-------NIRLH-KIA SNQE-AV-MKAF-------PSKDRAKDLKDLA-----------------------LGVDP -LPAQ-----------------RT--LG-------------------------------- -----LIWNLQSDSFAFLVSREEKPFTRRGVLSAINSLFDLLGFVA-------------- ----------------------------------------------------------AQ VPPFTHVGVDVFGPWN-------------------------------------------- ----------------------------IC--VR-RTRGSLS-EG-----KR-WAV---M -FSCLV--TRAVHIEVVESLSTASF-----INALRRF-TAIR-GPAKLFRSDRGTNFVGT CKELG-I-------T---PQDT-E----------------------LQ---SYLNEQGCT ----WEFNVPHSSHMGGAWERMIGIARRILDAMLL--KL--HSPKL----SHEVL----- --VTL-----LAEVVAIMNARP--------I--------------I-------------- ----------------------PV-------------SS--------------------- ----------- >1065/1-558 ---NTKRQLLSDTSRLFDPFGWIAPVIVRAKIMFQH-LWLY-D----------L------ -QWDD-P-LPA--CICDEWIELKETLHHIE---A-IRIN--R-W--I------------- -PHYDNT--L----ELHG-FADASEA-AYA-AVIYAR--SKDE-SG------NVYV-N-- IVAA---------------------------KTKV-API--Q-Q---------------- --------------------------------ISLPRLELLAAE-LLV-DLMVKVMES-- -F------S-HLT---VEL---HA---------WT------------------------- -------------------------------------FYLPHHAV-------WKED-SST TKL-RVVFDASSKSA-SG---VSLNDRLLVGPNVN--EPLFNVCCRWR---SYRF--AFT ADAEKMYRQIRIDHR--DKDFLR-----I------VWRED---P-SR---------PL-E HYRLLTVTYGTGCAAYQAIAA-LRKT------------A----DDN-QEQY--P-RAAER I-PKN--FYVDDL-FSGAD-T---IEDAMVLRKEIV-DV-LTSA-------GFNLR-KWH NNNA-KL-LG-SVENSNEPYQVKL-ADEYD------------------------------ ---EV-----------------KA--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------QP ARPFVHVGVDYAGPLN-------------------------------------------- ----------------------------IRSS--NLRT---ARMT-----KG-YVA---V -FVCLS--TKAVHLEAVTDLSTDAF-----IAALKRF-ISRR-GLCTEIWSDNGTNFVGA EREIR-R-------YLQSPEFN-G---------------------SVG---RFLGDLKIK ----WTFITPSAPHMGGIWEAAVKSMKKHLRAVIG--N-----TTM----TFEAF----- --CTI-----LAQVEACLNSRP--------LCE------------L-------------- ----------------------SK--------SID--S-------CEALTPGHF------ ----------- >1066/1-545 ---PSKRNALSCIMSLFDPLGLLALYIVHGKMIIQG-LWRS-G----------C------ -LWDH-T-IDD--DSMKKWSRWIALLPEVQ---S-MRIP--RCY--F------------- -SCASPS-DYENL-QLHV-FTDASED-AFG-CVAYFR--VLVN-GQ-------PRC-A-- LVSA---------------------------KSKV-APL--Q-H---------------- --------------------------------LSIPRLELQAAV-LGA-RLSASVKDN-- -H------S-VQV---KRL---FL---------WT------------------------- -------------------------------------WYLPLSVV-------QHPK-K-P GKI-RLVWDAAAS-V-EG---KSLNSELLKGPDFL--TSLPAVLSPFR---ERPI--AFG GDIMEMYHQVLIKPN--DKSAQR-----F------LFRPN---G-SA---------S-PV IFTMDVATFGSTCSPSTAQYV-KNYN------------A----KSY-AERF--P-DAVEA I-IKK--HYVDDY-FDSTD-T---AEEAITRAQEVA-FI-HAKA-------GFKIR-NWV SNNV-EF-QRYF--GE-----NGDNQVIHFNS-----------------------D-KIT GT--E-----------------RV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PQ LRPFSFVGIDYFGPVT-------------------------------------------- ----------------------------VA--IG-R-----R-SE-----KR-WIC---L -FTCLV--TRAIHMEVAHSLSSQSC-----IMAIRRF-SCRR-GAPLEFFSDNGTNFQAA SKEII-Q-D------VRK-IVL-E----------------------CA---EVFTDARTR ----WNFNPPSAPHMGGTWERLVRSAKEALKA-LH--D---G-RKL----SDEIL----- --LTV-----LAEAEDMVNSRP--------LTY------------V-------------- ----------------------PQ-------------ES--------------------- ----------- >1069/1-551 ---FTRRKVLEIMASLFDPLGLVSPCLVEPKLLFQK-LWD-KP----------K------ -NWDE-E-LEI--NHLNEWKYIIKNWIN-Q---E-IIVS--RKA--M------------- ----EKGIDTK-Y-QLHA-FVDANKN-TYA-AVIYLR--SENNGN--------VKI-S-- LIYS---------------------------RNRI-KSK--K----QN------------ --------------------------------LTIPRMELLALL-IGV-RALKFVNNE-- -L------K-LNID---KK---FV---------WC------------------------- --------------------------------------FLPHRPV-------FKG--E-- -KI-REVYNASARTR-GR---KSLNDCLFRGPLKL--PDLAGMLMRFR---LARF--PLL SDIEKAFLQIELEEP--DREVTK-----F------LWLRD---I-NR----PLNSNNL-I IYRFTRVAFGIICSPSLLAMT-IEHH------------L------NKYPG---Q----EN L-FKN--VYVDNV-FVDCD-T---EEEVYEKYVELK-KI-FYEG-------KMNLR-EFV TNAR-KA-LEKIPEEDK--L---------------------------------------- IDLNQ-----------------KV--LG-------------------------------- -----IKWNLKTDNLEIKFPSINL------------------------------------ ----------------------------------------------------------QS TSPFKSIGIDHLGPSF-------------------------------------------- ----------------------------YKEI-DNQDK------------KF-WIT---L -ITCLC--TRAVYLEPVKNLKADTC-----LNVLKRF-AARR-GCPERILSDNSKTFIAC AK-----------------------------------------TCKIH---LKIIGKDLE ----WKFIRELSPWQGGVYERIVALVKDAFRKTLG--K-----RSL----KWEEM----- --LTF-----TTEVEGILNMRP--------LTT------------I-------------- ----------------------DE--------NPDIPG-------IIPLRPVDF------ ----------- >107/1-550 ---PTKREILQVLMSVFDPLGLISCYTIGLKMLLQK-VWRS-G----------I------ -DWDE-E-LPE--ELLQFWMQWKIVLLQAT---K-LEFP--RHY--S------------- -RLLPEA---EQI-DLHT-FVDASEY-AYA-AVSYLR--IKK--EN------NVDT-V-- IVAA---------------------------KCKV-APL--K-P---------------- --------------------------------VSIPRMELLAAV-MGV-GLAKKIKNT-- -R------G-LRI---DNC---TY---------WS------------------------- -------------------------------------WYLPIFIA-------LNPN-K-P NKV-RLVWDAAAK-S-HG---KSLNDFILNGPDYL--NPLAEVLMAFR---VGRI--AVC ADIAEMFHQITIQES--DMQVQR-----F------LWFHN---DK-----------KTPR TFVMRSMTFGICCAPCIAHYV-RDKN------------A----EAF-KDTN--P-RAYES I-TKA--HYMDDL-IDTYN-N---DSEAVSVASAVK-DI-HANA-------GFTIR-NWI SNSA-AV-MHHF---G----------ERQLNT-----------------------HNPRE LGGPE-----------------KV--LG-------------------------------- -----MYW---------------------------------------------------- ----------------------------------------------------------SF ERPFTYTGMDYFGPIL-------------------------------------------- ----------------------------VN--VG-R-----H-KE-----KR-WGV---L -FTCLT--LRAVHLEVAHKLDVSSC-----IMCLKNF-MALR-GVPKEIYSDNGTNFKAT EKVVK-E-------ELKRINFD-N----------------------IT---ILY--DAII ----WKFNPPAAPHMGGAWERLVRSVKSVLKSICP------T-NNF----NDETL----- --RTA-----LMEAETILNSRP--------LTF------------V-------------- ----------------------SL-------------DSEDEEALTPNHL---------- ----------- >1072/1-540 ---DVVRSV-----------GTARTILIHGKILIQN-LWRS-G----------S------ -EWDE-A-VKD--PEYHLWKEWIKMIECIA---L-VRIP--RCY--F------------- -ELATRA-TYADT-QLHI-FVDASES-AFA-CVVYFR--TTGE-NG------ISQC-S-- LVAG---------------------------KAKV-APV--K-P---------------- --------------------------------LSVPRLELQGCV-LGT-RLMKFVQEN-- -H------K-VKI---ARK---IL---------WT------------------------- ---------------H---------------TDPRKIWYVPLGAV-------SNAK-K-P GKV-RIICDARAQ-I-EG---VSLNSVLLKGPDLM--TSIISIIFGFR---LYKV--AVS ADVQEMFHQLLIRSA--DKHAQR-----F------LWRSN---P-SE---------Q-LQ IYIID--NVWATCSPASAQFV-KNLN------------A----KEH-SHRY--P-EASDS I-INC--HYVDDY-LESFE-S---EEEAKRIAAEVR-LI-HRNG-------GFNLR-GWI SNSE-HV-LQSL--ED--KEPMGEATIKNLNL-----------------------ID--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DH VRPFSYVGVDYFGPML-------------------------------------------- ----------------------------VK--IG-R-----S-NV-----KR-WGA---L -FTWLT--VRAVHIEVAHSLSTASF-----ISCVRRF-ISRR-GAPLEFFSDNGTNFHGA ERILQ-D-Q----------INQ-G----------------------LS---ETFTNAATK ----WTFIPPGAPHMGGAWERLVQSVKIAMGT-AY--S---D-GKL----DEEGL----- --QTL-----FIEAEGLVYSRP--------LTIGFXRGGSTHSQPL-------------- ----------------------PA-------------WK--------------------- ----------- >1073/1-578 ----TKRTILAFIASHFDPLGLITPLLLPLKIFMQK-LWE-NK----------F------ -KWDD-P-LPT--DLAEKWHALLKEWTETT---N-ISIP--RLL--SANYQYQEEQQRAF SQLEEAPLLDKKY-QLHC-FTDASEA-AMC-AAIFIR--SVDTSDN------KMDA-R-- LIFS---------------------------KTKV-KPI--K----STK----------- ---------------------------------TIPILELIAIV-MGV-KALKFVQSH-- -L------S-NIDID-PTL---NL---------WS------------------------- ------------------------------Q----PV--ITH------------------ -KL-RIVYDGSAHIG-KE---NSLNDTLEPGPVIL--PDLVGILLRFR---FPPI--VII TDVMKAFLQISVNPS--HRDATR-----F------IWLKS---I-EE----PLYNNNL-Q IYRFTRVPFGLCCSPFLLGAT-ILHH------------L------SQFPS---P-LS-DE I-SAN--TYVDNI-VFSAQ-E---IQEAQKKVIAVN-SL-FLKA-------NLELQ-EFA SNSK-EA-LDPIPESKR--L---------------------------------------- QGPNQ-----------------KI--LG-------------------------------- -----LCWNTDSDLLKITIHPF-------------------------------------- ----------------------------------------------------------SP SRPFLATGLDYCGPLH-------------------------------------------- ----------------------------IRTDKRFPKS---PNTNT-VKTKKFWVV---V -WVCLS--TRAISLDYVPDQTSEAF-----LLAFRRF-CSKF-SPPNTIYSDSAPTFISF KKFFE----------------------------------------------NLQNTQPIT ----WHLRVPYAAWRGGFYERLIALVKFHLRRSLA--K-----GLFPHISKFDTF----- --LTT-----LTEIESCVNSRP--------ISF------------C-------------- ----------------------SA-------------NPADPLPLRPIDF---------- ----------- >1076/1-658 ---PTKKEVIAFLAQNYDPTGIITPIVVPIKKLITL-LW-QFD----------L------ -KWSD-L-IPD--VLTPLWNSIITHFTETE-----YVIP--RQV---------------- ---V-SSYNYTGV-QLVL-FSDASKD-NYA-AAAYLR--HEF-PGQ------KYES-Q-- LICS---------------------------KSRV-KPGRVG------------------ --------------------------------ITIPQMELLALE-SAT-NLALNLMNE-- -L------H---MPI-KQV---IF---------FS------------------------- -------------------------------KPSGPIFYFPHRGV-------RKE-SSVN TKL-RIVLDASSHGK-GK---LSLNDCIHPGPSIL--QSIFGILIRCR---LKKF--LMI SDIEKAFHQIRLQPQ--CRDSTR-----F------LWLKD---P-TK----DATPDNI-L VLRFARLPFGVNCSPFLLAVT-ILQY------------L-------ENEPN--P-IN-AK I-LEN--LYVDNI-VMTTN-D---EDELFAYYDQLK-NT-FNRM-------AMNLR-EFL CNCP-EV-MEKTKEDDR--A---------------------------------------- PDTAN-----------------KL--LG-------------------------------- -----HTWDSLTDVISIKIATPPNGIPTKKEVIAFLAQNYDPTGIITPIVVPIKKLITLL WQFDLKWSDLIPDVLTPLWNSIITHFTETEYVIPRQVVSSYNYTGVQL----------QL VAPFAFVGLDYLGPLK-------------------------------------------- ----------------------------YK-SKD-EYE------------KI-WVL---L -VTCIV--TRAVHLEIVQDNTTHSF-----ILALKRY-FGRR-GVPQSILSDNSPTFKLG YSMMN-A-------DLKT----------LISK-----------SLTLT---SFLADKEID ----IRFITPFSPWKGGIYERLVALVKNMIHKCLK--K-----ITV----SLLEL----- --ESL-----LIETECIINCRP--------ITA------------N-------------- ----------------------KI--------HTA--D-------AEPVRPIDY------ ----------- >1077/1-528 ----TQRELLSQVSGLYDPLGFVTPVKQKGAILVRR-AFQEVK----------GKCSRVE STWDT-A-LSD--NLREDAICLLEDYAEVN---K-LRFP--RAL--T------------- -PPNATNPPYGIT------FSDGSEH-SYG-AVLYLR--WSCQ-QE-------TVI-R-- MVES---------------------------KAKL-TPLDHK------------------ --------------------------------GDAVKAEVCGAV-YAA-RLKKYFEKN-- --------CTIQV---KKW---FH---------LI------------------------- ----------------------------------------------------PNPH-SVT TPV-RLVWNSSQV-F-KG---QSLNNILLKGPDVL--NNIRAVLIRFR---EGVY--AAL GDIKKMYNSVWLEDK--EMHLHR-----F------LWRDT---E-ED---------EISQ -YAITRVNIGDKPAGCIAQVA-MRET------------A----SLP-EFSH--LKAERRV L-EED--TYVDDI-LTSHN-D---WALLQQIITNVE-KI-LRAG-------GFKLK-PWI CSGQ-SG-REH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------KP AAPFQFIAVDMFGPYL-------------------------------------------- ----------------------------VKDDVKRRVTM-----------KV-WGV---V -FSCMA--SRALHVELVNSMSTESF-----LMAYQRF-TALR-GHPQKVWSDPGTNFIGA KPILE-D-------LYKFLQAQ--------------------NKTDLE---EYAIRNGTT --WTWKVLPADSPHRNGAAEAAVRIVKRALQSLNK--T-----LNL----TFSEF----- --LTV-----IQLAANLANERP--------IDA------------R-------------- ----------------------AQSQEDC------------------------------- ----------- >108/1-568 ----TKRGILSVVSSIYDPLGFAAPVLIKGRLLWQK-LCKR-G----------L------ -DWDE-P-VLQ--SEADEWKSWLDVLPGLE---D-VRIS--RCF--R------------- -PPEFGN--VAIT-ELHH-FADASTA-AYS-AVSYLR--STDD-NG------NVHC-A-- FLFG---------------------------KARV-APT--S-T---------------- --------------------------------MSVPRLELTAAV-LAV-RNDQVARRE-- -L------K-LSD---CQS---TF---------WT------------------------- ---------------L---------------NASNYRWFIPHHPV-------MHPR-K-P GKV-RVVFDCAAK-H-KG---LALNDILLQGPDLM--NSLVGVLMRFR---IHQV--ALV ADVEAMFHQVRVEPK--DRKTLS-----F------LWWKD---GNLE---------SKPL VHEMLVHLFGATSSPSCAAFC-LRQT------------A----IEF-GHLY--DDVVSEV V-TNN--FYVDDC-LVSAR-D---VNEAVRLVAQLR-DL-LSQA-------GFRLT-KWL TNNQ-QV-LDSI-------PEQDRAKNVKTMK-----------------------I--DD -CVDE-----------------RV--LG-------------------------------- -----VQWLVSCDKFTYTVVKK-------------------------------------- ----------------------------------------------------------SD KPAFSSVGIDYFGPFY-------------------------------------------- ----------------------------VK--QG-R-----S-QI-----KR-YGC---L -FTCLT--MRAVHLEVACDLSTDSF-----LNALRRF-TGRR-GKPEHIYSDNGTNFVGA AKILR-S-------SIKKWNHQ-H----------------------IA---EHLRQKEIS ----WSFNPPAASHMGGAWERIIRSVRRVLSSLQS--P---KT-VL----TDETL----- --QTL-----FVEVESILNSRP--------LVP------------V-------------- ----------------------T--------------------------I---------- ----------- >109/1-559 ----TRRSILSAINSLYDPLGFVAPVVLVAKILQQE-IVRQ-N----------L------ -GWDQ-E-ISE--DCAEEWRNWFKQLPELH---R-LAVP--RCF--K------------- -PNDIGV--IVKS-QIHH-FSDASIN-GYG-AVSYLR--LVDD-NG------KVHC-S-- FLCG---------------------------KARV-TPP--K-T---------------- --------------------------------ESIPRLELVAAV-LSV-KADKWLKGQ-- -L------K-MPA---CES---IF---------XT------------------------- ---------------Q---------------DTSDTVWYLPHHPV-------YHPH-K-P NKV-RIVFDCAAK-Y-KG---VSLNDALMQGPDLV--NSLVGVLTQFR---KEPI--AVV ADVEAMFHQIRVKEE--DCHALR-----F------LWWPG---GDLY---------KRPV DHQMLVHVFGATSSPCCASFC-LRQT------------A----DQF-GEQF--DNNVSEV V-KNS--FYVDDC-LTSIP-T---EEEAIRLVEQLR-LL-LQKG-------GFRLT-RWI SNNQ-RV-LKEI-------PKNERAASVKDID-----------------------L--DN -PVKE-----------------RV--LG-------------------------------- -----XYWDVFKD----------------------------------------------- ----------------------------------------------------------MR EPIFSYVGXLYFGPFL-------------------------------------------- ----------------------------IK--RG-R-----S-EV-----KR-YGC---L -FTCLS--MRAVHIEVATDLSTDAF-----INAYRRF-VGRR-GKPVEIYSDNGTNFVGA ERELR-E-------SLNALKEEPK----------------------LN---SFFRQQAIK ----WTFNPPTASHMGGVGERMIXSIRKILNTMMW--K---S--QV----VSDVF----- --HTL-----MVEVENIVNSRP--------LTP------------I-------------- ----------------------S--------------------------S---------- ----------- >1092/1-569 ----TKKRAVGEITLIFDPNQYFAPLYLEGKLILRS-ISDH-S----------L------ -KWTD-C-VNK--ETVEEIIAYRQKIENST-----LKFK--RLI---------------- ----ENLDENTPV-QIAV-FSDASET-SYG-ACIYLLLEKKDA-KG------VFKT-E-- LLIA---------------------------KQRI-ASKQKT------------------ --------------------------------LTIPRLELLGVL-IGV-RLLNYTLEQ-- -M------N-INV---QKI---EM---------FS------------------------- -------------------------------------FYLPYGLV-------FNYS-SNT TKV-RTVFDASSKKRGE----KSLNNVLHQGPTLV--PHLLGILLRLR---QGRF--LFS GDIEKAFHAIEVNEE--DRDALR-----F------VWLKN---P-NE----PISQ-NNLR FMRFKRLPFGVNCSPFLLSMSILHAV------------R--------QENV--PRALVNS I-ETM--CYVDNI-FFLTD-K---ESDLPIMYELLK-KF-FSNI-------GMNIR-EFS VNYP-EN-F-------LREEDKAKNI---DNV---------------------------- ----------------------KM--LG-------------------------------- -----YIY---------------------------------------------------- ----------------------------------------------------------TE SRPFQHVGVDFAGPFK-------------------------------------------- ----------------------------TYLRNSSEVE------------KS-YIA---F -FTCTT--TRLVHGETVRNLSTDEF-----LLSLSRF-MSRR-GYPDSITSDNATTFKLT AEILD-K-------CSEKEDNY-LAELAFDKL-------DKQKLDFLE---KEMAKKKVK ----WYFNTALAPWQGGFYERLIGVLKKALKHSLG--D-----SLL----RIKDF----- --ETI-----VAECESLVNRRP--------LTY------------I-------------- ----------------------DE--------DGE--D-------YKVLRPIDI------ ----------- >1096/1-561 -----RRTVSSSIAIQFDPHGLLSPILLPMRLFQRE-LWED-E----------F-----N YNWDT-A-LIE--DHEKRWTELVNAANNFT-----IQVP--RQV--T------------- -RKTKDN-------FIVT-FTDASKD-ATA-CCTYVV-------ND-------IGS-H-- IIFG---------------------------KSKI-KPLKEV------------------ --------------------------------FTIPKLEMQALK-MGT-EKTAEVIKA-- -LQDGKIIV-------TKV---FI---------FS------------------------- -----------------------------------------HQPV-------LTP-TKTT TKC-RVVIDGSSHFK-GK---PSLNDIIHQGPTIL--PDLVHLILRFR---SGSI--ALV SDVEKAFLQVFLHED--DRDYTR-----V------LWVKD---I-DA----HFSGENI-I ELRFTRVLFGLNISPFLLGAT-ILHH------------F------EQLEDK--E-LA-NE M-SKN--LYVDNL-ILTTDKA---PEDAISLYRGAK-QA-FSEM-------SMNLR-EFQ TNSS-EL-ADHIDIVDR--A---------------------------------------- KEIEM-----------------KI--MG-------------------------------- -----IKWDSQLDVLIMGVHI--------------------------------------- ----------------------------------------------------------QR ARPYENIGLDYFGPMQ-------------------------------------------- ----------------------------YRIS-AEEIG------------TA-FGV---I -FTCSV--SRLTHIEIAPDYSTRAF-----IQALRRF-ISLN-GLPTSIVSDNAPAHILG EKMIN-E---------SIVKE-------TEQM-----------SAEVI---EFLAIHAIQ ----WKYNTPYAPWQGGFFERLIRIVKEHLVRAIR--T-----SIL----TYEEL----- --RTI-----FLEIAASMNSRP--------LTM------------P-------------- ----------------------SS--------DNN--S-------NPPMRPIDF------ ----------- >1097/1-560 ----TRRELLSQVSGLYDPVGLGTPVKQKGAILVRK-AFQEAK----------VKKCSIE ETWDT-P-LSE--GLRQDSISLFEEYVQLA---L-IRFP--RSL--T------------- -PAHFKGDPLAIT------FCDGSEH-AYG-AVMYLR--WEKE-QG-------LVT-R-- IVES---------------------------KARL-TPVDQN------------------ --------------------------------GDPGKSEMCGAV-FAS-RLKKYFEDH-- --------SQIKV---KKW---YH---------LL------------------------- -----------------------------------------------------NPH-SAS TPV-RLVWNSSQR-F-KG---ISLNDLLIKGPDVL--NPIRAILLRFR---CGVH--AAL GDIKKMYNSVWLEEQ--EMHLHR-----F------LWRDS---E-MQ---------DIED -YAITRVNMGDKPAGCIAQLA-MRET------------A----NLP-AFSH--LEEERNV I-HQN--AYVDDI-LVSHN-N---FEQLRTLTDNVE-QI-LKSG-------GFELK-PWV FSRQ-KK-GQK--ESQEQWGSRPGPMVLPNQI--------------------------KH NENKA-----------------LG--LG-------------------------------- -----YEV---------------------------------------------------- ----------------------------------------------------------TP AAPFQFTTVDLFGPYH-------------------------------------------- ----------------------------VRDDVKRRVTK-----------KV-WGV---L -FCCMA--SRAIHTEVANDLSTEGF-----LVAYQRF-TAIR-GHPRKIWSDPGTNFIGA KSVLE-E-------MYKFLDQR--------------------NKASLE---DLSARNGTE --WTWKIHPADSPHRNGAAEAAVRIVKRALQTIGK--E-----SAL----TFSEF----- --QTT-----LSLAANLANERP--------IDA------------R-------------- ----------------------TQSREDC------------------------------- ----------- >1098/1-567 ---QTKRQLASQIAKVFDPLGWLIPVTVFARAIFRI-VCQA-S----------F------ -DWDD-P-LPS--SIVQEWAQFAVSLPDLS---K-IHIP--RFL---------------- ------SLPNPKC-YLVG-FADASER-AYA-AVVYLV--SQSE---------DTVI-S-- LVMS---------------------------KARM-APM--K-P---------------- --------------------------------VTLPRLELCAAH-LLA-LTINKVRLLFP RI------T-------TQI---IL---------AF------------------------- ---------------------------------------IPHHAV-------HRLD-DPP EKI-RVVFNASQKSS-SG---ISLNELLLPGPRLQ--LDIWKVVTRFR---VDKW--VFT ADIRQMFRQIQHPPE--DRDLLR-----I------LWRFD---T-SQ---------PV-X EYRLCTVTYGTTSAPYLACRV-LQEL------------A----LTS-QASF--P-LASEI L-RDR--TYVDDI-SGGGP-T---LEVALQSRDQLI-QL-LSQA-------QIELR-KWA SNHP-QL-LNKIPSEYLLPAMSSVCLENDE------------------------------ -ESQL-----------------KI--LG-------------------------------- -----LCWNPAQDYFHFLIRSV-------------------------------------- ----------------------------------------------------------SA SSPFTTTGIDYAGPFN-------------------------------------------- ----------------------------VKIA--SLCS---AKV------LLSYLA---I -FVCFS--TKAIHLELVTDLTTQAF-----LAALNRF-VARR-GVPSHIWSDNGTNFVGA KRRLK-E-------VSALLNDA-KS------------------QEAIL---RESNKRSIE ----WHFIPPRAPHFGGLWEAAVKSTKRLLKVTLG--T-----QEP----TMECF----- --LTI-----ICQIEAILNSRP--------LTA------------V-------------- ----------------------SS--------SPD--D-------L-------------- ----------- >11/1-559 ----TRRVVLSEVGQIFDPLGLFAPVVVRAKMFLQH-VATE-R----------I------ -EMDG-D-LPP--YLEKQWEAYREDVQALN---H-MKIP--RHI--F------------- --DGKV-PT--TK-ELHT-FVDASEK-AYG-AAVYVR--STYK-NG------QISV-R-- LLCA---------------------------KSRV-APL--E-K---------------- --------------------------------QTLPRLELCAAV-LGA-ELTDRVRQD-- -L-Q----F---G---SESVESFL---------WS------------------------- -----------------------------------NHYFIPHHCV-------LKPE-STT TKL-RVVFDASCKTS-SG---KSLNDILYPGPVVQ--SQLFSILLRFR---THKY--VFT ADIEKMYRQVWINPA--DQFNQM-----I------VWRED---P-SQ---------EL-K FYRLKTVTYGTTSAPYLATKC-LEYL------------A----LKN-IEKL--S-SGASA L-KND--FYVDDC-LTGAD-S---LPEALQIRQELL-EI-LKPK-------GFNLR-KWC SNSS-QL-LKEIPKEDTIADINLG-DT-LE------------------------------ -QTSV-----------------KT--LG-------------------------------- -----IIW---------------------------------------------------- ----------------------------------------------------------SQ NRPFLNAGVDYCGPFW-------------------------------------------- ----------------------------IHHK--VRGK---RPD------KA-YIA---V -FVCFA--TKAVHLELVGDLSTSSF-----VGALQRF-IGRR-GRCQTLYCDNATNFVGA NNQLK-E-------LTDTIHSE-TA------------------AGSIK---EFCNQKGVQ ----FKFIPPRSPHFGGLWEAAVKSAKHLLLKNVS--T-----ANL----TFEQL----- --STI-----IVNVEAVLNSRP--------LTP------------N-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >110/1-525 ----TKRIILQFVASQYDPLGFIVPILIRFKLFLQT-LWK-KN----------L------ -SWDQ-T-ISE--EDETTWKLLTNEWPK-K---L-KDLP--RFT--T------------- ----N---CSKQV-QFHV-FTDASTA-AYS-AALYIR--TQ---E--------REV-F-- LVFA---------------------------KSRI-API--K-------G---------- --------------------------------MSIPRLELLAIL-IGV-RMVQFVLKQ-- -K------E-LEDV---IT---IL---------WS------------------------- -------------------------------------HYLPHHEV-------ITP-NKTT TNL-RIVYDASAHCK-GM---KSLNDVLYRGPITL--PDLVGVLLRFR---TMKN--VII ADVEKAFLQIELHPT--DRNCTR-----F------LWLKD---I-RS----PVNEENV-S CYRFQRVPFGIVSSPFLLSAT-LNYH------------L------ETCKS---K-IA-LE L-RKN--LYVDNI-IIPTK-G---TNEALSNYKEIK-II-FNEA-------SMNVR-EFL SNDQ-EV-NEKLPVQDR--AE--------------------------------------- VSSIK-----------------KI--LG-------------------------------- -----LNWYH-------------------------------------------------- ----------------------------------------------------------TR SRPFARVGLDYLGPVN-------------------------------------------- ----------------------------IRS--DNGLT------------KR-WVA---L -FTCFT--TRAVHLEVVETLSAESF-----LHVFRRF-TARR-GFPELILSDNAGQFQLI FKIIV-K--------------Q------QL-----------------N---EFLAERKMI ----WKNIIPKAPWNGGVYERLIGLTKRAMKRAIG--R-----KLL----WEREL----- --ITL-----VAEVESILNTRP--------LTY------------V-------------- ----------------------NF------------------------------------ ----------- >1103/1-549 --------WLSDSAKLFDPFGWFAPVIVRVKILYQK-CWLY-D----------L------ -NWHD-K-LPP--TIEEAWVEVKENLHLLE---S-VKLP--R-W--A------------- -ANYNGR--I----ELHG-FSDASEE-AYS-AVVYLR--SVES-NN------EVHV-T-- LLAA---------------------------KTKV-APV--R-Q---------------- --------------------------------ISIPRLELNAAE-LLA-KLVKQVAAP-- -L------E-RFQ---IDQ---YA---------WT------------------------- ------------------------------DADCSKSYYLPHHGV-------IKED-SVT TKL-RVVFDGSSATT-TG---ASLNDILLEAPNIN--ADLFDVLLRFR---SYPV--VFL ADIEKMYRQVLVHPD--DTDYMR-----I------VWRDS---P-DK---------PI-Q HFRLLTVTYGLKNSGFLAMTA-LHKA------------A----EAF-EERY--P-KAAER I-IKH--TYVDDL-TSGAD-S---AEEAIEIIKQIN-EI-LGEA-------GFTLR-KWS SNSP-EV-LDSLSDTISSAMPIQF-PDERN------------------------------ ---TV-----------------KA--LG-------------------------------- -----THW---------------------------------------------------- ----------------------------------------------------------TA CRPFAHVGVDYAGPIS-------------------------------------------- ----------------------------VRCS--NTRG---ARCM-----KG-YIV---V -SICLS--SKAVHLEVAGDLTTDTF-----LGAFKRM-IARR-GYCNEVWSDNGTNLVGA DRQLQ-E-------IYEVVTKH-VK--------------------QGE---HFFTNLGIR ----WRFIPPASPHQGGIWEAAVKSAKELLRPILG--N-----EKL----THEEL----- --STV-----LCQVEACLNSRP--------LCP------------M-------------- ----------------------SS------------------------------------ ----------- >1104/1-553 ---ATKRSVLSTIAKMYDPLGMMAPIIIRAKIIMQE-MWVS-S----------C------ -DWDD-P-LPD--CIVAKWKQFQREVSSLT---N-CSMD--RYV--L------------- --LP-N-VT--KM-ELHT-FADASIA-AYG-ACTYVR--SEEA--G------VVRV-V-- LLAS---------------------------KSKV-APL-------K------------- ---R----------------------------LSIARLELCACV-LAA-HLHNRIKRA-- -I-D----M-R-I---DGS---WF---------WT------------------------- -----------------------------------ECYYLPHHPV-------FKET-STT TKI-RVVFDGSAKTT-SG---FSLNESLCVGPVVQ--DDLLDQLLRFR---TYRV--ALV GDIAKMYRQVLLHPD--DRALVR-----I------LYRFS---P-Q-----------L-Q EYELNTVTYGLAPSSFLATRT-LVQL------------A----EDE-GAGY--A-LAGSA L-KKN--FYVDDF-IGGAQ-S---IEAAIQLRKELS-VL-LSKG-------GFELR-NWT SNRL-EV-LEGLDDSQIGTKS--S-L-CFA---------------------------T-- -HETV-----------------KT--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------QP SRPFAVTGVDYAGPFY-------------------------------------------- ----------------------------LKPV--HRRA---ASL------KA-YLC---V -FVCFA--TKAVHLELVGDLSTQGF-----LAALRRF-CARR-GLPEHLHSDNGKNFEGA RNELK-E-------LFERLSNE-AE------------------MGAIA---KSCAEQGIR ----WHMIPPRAPHFGGLWEAAVKTAKRHLFRHLG--S-----TRL----SFEGY----- --YTV-----LHQIEAAMNSRP--------LLP------------V-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >1107/1-550 ---PTKRQVLKCLMSLFDPLGLISNFTIHGKILMQN-AWRK-R----------L------ -GWDE-P-IDE--DLYVEWKRWIENLKFLY---T-LKIS--RCY--F------------- -AGVTSK-IYNTM-QMHI-LVDASEQ-AYS-TAVYFR--IVRP-NG------SIEC-S-- LVSA---------------------------KSKV-APL--K-T---------------- --------------------------------IFIPRLELCGAV-LGT-RLAAFIQAQ-- -H------N-INI---SKR---YF---------WC------------------------- -------------------------------------WYLPIGLV-------INPK-K-P GKV-RIIWDASAT-V-QG---VSLNSTLLKGPEELITTILPSIYFRFR---QFPY--AVS GDIREMFHQVRIRKE--DSNVQR-----F------LWRTD---S-SS---------N-PT IYIMDVATFGSTCSPASARYV-KDLN------------A----ATF-KDQY--P-KAYDA I-INE--HFVDDF-VASFE-S---IGEAKTIAKQVK-DI-HSNA-------GFCMR-NWI SNRP-EI-VKEL--GE-----LDNTNEKTIGL-----------------------P-NEE YS--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------VG FRPFTHVGLDYFGPMT-------------------------------------------- ----------------------------VK--VG-R-----S-AV-----KR-WVT---L -FTCLT--IRAVHLEVAHNLTTESC-----IACVRRF-ICRR-GAPSVIYSDNGTNFKGA KAILE-Q-Q------LAP-INR-E----------------------LS---ISFTNTDTQ ----WNCIPPATPHMGGAWERMVRSVKEAMRSIAS--A---EMKNL----NDEGL----- --LTL-----VGEVEKIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >1108/1-528 ----TMRNIYKVLARQYDPLGFIAPYTTRAKLIVQS-MWDK-P----------R------ -DWDD-PCIPP--DLQKAWTTWESELHWLP---H-IAVP--RPY--A------------- -PGLTEP-MVVSR-QIHV-FSDASTK-AYG-SVAYIR--TEDV-QG------RIQV-A-- FLAA---------------------------RSRV-APR--R-Q---------------- --------------------------------HSIPRLELCGAL-TAA-QLAKKIETE-- -L------T-IKT---DKP---IL---------WS------------------------- ---------------V---------------LDSAESYYIPHHVV-------HHN----- GKS-RIVFNCSFP-Y-QG---RSLNDTLLPGPTLG--ASLLGVLLRFR---EHAV--AIS SDIRGMFHQVELLPE--DQPLLR-----F------IW-RD---MKRA---------DPPA VFQWQVLPFGTACSPCCATFA-LHRH------------A----RDH-SGV---NNAVLHS V-EHC--FYVDNC-LQSLP-T---AEEAKELVDQLR-DV-LASG-------GFELR-QWA SNVP-DV-LRHL-------PAEV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LY QPAFYSTGVDCFGPFQ-------------------------------------------- ----------------------------VR--IG-R-----R-SE-----KR-WGI---I -YKCLT--TRAVHLDLLHAMDSDSF-----LMSLRRF-IARR-GSPAELYSDQGTNFRGG EKELS-E-------WFSRMSPD------------------------LQ---QLLAKQKIA ----FCFNPPAAPHFGGTWEREIKSVKMALNTVIG--A---Q--PI----SEEVL----- --RTV-----LLEVEAILNSKP--------LGY------------T-------------- ----------------------SS-------------NV--------------------- ----------- >111/1-559 ----TKRVVASDMAMIFDPYGLIGPVVVQAKIFVQK-LWRM-E----------L------ -DWDA-A-LPE--DLQEYWREYRRNLAGLD---S-LSIP--RWI--G------------- --TGAD-DQ--NV-QLHG-FCDASVN-AYG-ACIYIR--TVSA-NG------DVTV-R-- LLAS---------------------------KSRI-APL--E-NLKK------------- ---KKRK-------------------------QSIPRLELASAL-LLA-HLYEKVANA-- -I-N----F---R---GKA---FF---------WT------------------------- ---------------------------------------LPHHCV-------LRPD-STT TKL-RVVFDASCRTS-TG---VALNDALMVGPVVQ--DDLLDIALRFR---LHAV--AIV ADIAKMYRMIRVQPD--DQRLQR-----I------VWRDN---V-DE---------PI-R IYELTTVTYGTASAPYLATKC-LQKL------------G----EIG-EKTH--P-SAAKV L-KRD--FYVDDM-LAGAH-T---VAEGKELVAEMV-DL-MESG-------GFSLR-KWH SNSR-DI-LLDVPEHLRDERT--L-L-ELD---------------------------T-- SDATV-----------------KT--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------TP CTPFARVGVDYCGPFQ-------------------------------------------- ----------------------------VAYP--QRRA---RPV------KC-FVA---I -FVCLV--TKAVHLELAADLTTQAF-----LAALKRF-TARR-GKPKLVMCDNAKNFVGA RRELS-E-------LAKLFLSQ-QF------------------EEEII---RETANDSIE ----FKFIPARSPNFGGLWESAVKSFKLLFKRTIG--L-----HTL----LYDEF----- --QTV-----LVQIEAILNSRP--------LTP------------L-------------- ----------------------SN--------DPA--D-------F-------------- ----------- >1110/1-543 ---TTRRTVLSSVASLFDPLGLVCPATLKAKLFFQK-LWD-DN----------H------ -EWDT-P-LSR--EEAREWEHILASWEG-E---S-NVIP--RGV--T------------- ----A-GRGHP-L-QLHV-FTDASEI-AYA-AAAYIR--TGGESG--------CNS-R-- LIMA---------------------------KSRL-KPK--K----AATT---------- --------------------------------FTIPRMELMGIL-LGV-RLAAFIEKQ-- -L------H-HPIA---GQ---HI---------WS------------------------- ---------------------------------------IPHQAV-------ITP--K-- -KL-RVVYDASAHTR-GA---PSLNDCLLRGPVWL--PDLAGMLIRFR---ACRV--PVI ADVEKAFLMVGIEED--DRDVCK-----F------LWVRD---P-FR----PVTTDNL-V TYRFRRLAFGLTPSPFCLAAV-VRHH------------L------RKYDS---N-FA-EE L-IRD--TYVDNV-LIPAD-T---AEEAAIKGREAK-RM-FADA-------RMNLR-EFL SNDE-TL-NSSFSDAEF--L---------------------------------------- GKTTA-----------------KV--LG-------------------------------- -----LEW---------------------------------------------------- ----------------------------------------------------------QR RLPFESVGLDYLGPTA-------------------------------------------- ----------------------------ISDE-NGQRR------------KS-WVL---L -ITCLT--TRAIYIEATRDLTAQSF-----IMVLRRF-IARR-GAPSRIISDNAPTFTIV GKTLA-D--------------F--G---IT-------------NADPI---SFADSKGIQ ----WRFTPQHTPWAGGVFERAVQLVKRALQKTLS--G-----TVL----NYDAL----- --STI-----LAEIEATINSRP--------LTY------------V-------------- ----------------------NS--------TAG--D-------PLPLRPIDL------ ----------- >1115/1-614 ----TKRSALSQIARLFDPLGLLGPVVITAKLFMQA-LWLM-K----------T-DDGKP FDWDQ-E-LPS--SMQEAWFTYRSQLLLLN---N-LRIE--RFV--L------------- --SP-I-TI--SL-QYHF-FSDASKH-AYG-ACCYIR--STDT-SG------STKI-A-- LLTA---------------------------RSKV-APL-------K------------- ---Q----------------------------QSIPRLELCGAL-LAT-ELYQKVTSA-- -L-E----I-P-----GET---FF---------WV------------------------- -----------------------------------RCYHMPHHAV-------VRED-STT TKL-RVVFDASCKTP-EG---PSLNDALMVGPTVQ--QEIRSIIMRSR---THKV--MII ADAKQMYRQVLVDRR--DTPLQR-----I------IWRPS---P-EL---------PL-Q TYELLTVTYGTASAPFLATRV-LQQL------------A----DDE-QDNF--P-KAANI L-RKD--FYVDDL-FSGAD-T---IEQATELRQQLE-ML-LSKG-------GFQLR-KWA SNEE-AV-LEGIPPANRALQT--S-F-DLD---------------------------R-- -NQCI-----------------KS--LG-------------------------------- -----LHWEPASDKLKYYDGRYQNFEKCFFSLETGCGGESGNLQTGTYDTTQQRQRQRQY MAIQL-----------------------------------------------------TA TRPFTITGVDYWGPIF-------------------------------------------- ----------------------------LQPT--HRRA---APR------KA-YVA---V -FICFS--TRAVHLELVVDLSTAKF-----LQAMRRF-VSRR-GLCSDIHSDNGRNFIGA ANELR-H-------L---IQSK-DY------------------QQSMA---RECAENGIR ----WHFNPPRASHFGGLWEAAIRSAQKHFVRVLG--T-----HTL----PPDEM----- --ETL-----LTQIECCLNSRP--------IVP------------L-------------- ----------------------SD--------DAS--D-------F-------------- ----------- >1118/1-518 ----TLRNVYRVLATQYDPIGFLIPFTTRAKVLLQQ-LWVK-E----------R------ -QWDD-PVLPE--GIQKAWAAXENELPDIT---S-IQLS--RTY--G------------- -PVELDS-TSVKR-ELHV-FCDASEQ-AYG-SVAYLR--IVND-D-------KVLV-S-- FVMA---------------------------RSRV-APR--K-S---------------- --------------------------------ISIPRLELCAAL-TGV-QLANLLERE-- -L------D-LNI---QRT---IL---------WS------------------------- -----------------------------------ESWFVPLHLV-------KHN----- EKY-SLVLNCSYV-F-KG---DSLNTHLLPGPTLG--SSLLGVLLRFR---ENPV--AIS CDIKSMFHQVRLLPS--DKPLVR-----F------LW-RN---MRKE---------EPAD VYEWHVLPFGTTCSPCCATYA-LQKH------------V----RDL-SEN---CEDLKDS I-TKA--FYVDNC-LQSVS-D---IQKGKELVEKLR-AH-LKEG-------GFEIR-QWA SNVL-EV-VEV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LF KPLFWSTGMDCFGPFT-------------------------------------------- ----------------------------VK--TG-R-----K-TG-----KR-WGL---L -FKCQT--TRCVHLELLTGLDTDSF-----LMALRRF-VARR-GQPYEVICDQGTNFHGG ESELK-N-------AFEHLSPV------------------------LK---EKLWNHQIK ----FTYNPPYAPHFGGTWEREIRSIKSALRSTLG--S---Q--TV----KEEVL----- --ATV-----LVEVEEILNSKP--------LGY------------V-------------- ----------------------SS-------------SAE-------------------- ----------- >1120/1-552 ---PTKREALRLVMSIFDPHGLVANVVVHGKVLLQD-MWRE-K----------I------ -GWDE-K-ISS--ELFDKWQRWVKEVRNLD---K-VKIP--RCY--F------------- -SGYSAK-SLKTL-EMHT-FVDASET-ACA-ATVYFR--IVD--RG------QVRC-I-- LVTA---------------------------KTKV-APL--K-A---------------- --------------------------------LTVPRLEIQAGV-LGT-RLMRAVEEH-- -H------S-LNI---RSR---TI---------HT------------------------- ---------------S---------------ADPRRVWYLPLGVV-------LNPN-K-P GKV-RLVWDAAAK-V-RG---VSLNSMLLKGPDLL--IPLFAALFRFR---QFQF--AVT ADIKEMFHQVLIRPQ--DRSAQR-----F------LFRDD---P-AK---------P-MD TYVMDVATFGATCSPSSVQNV-KNLN------------A----EEW-SLEY--P-EAAKA I-TDG--HYMDDY-LDSLH-T---ENETVQLAQEVK-AL-HAKA-------GFELR-NWL SNSE-AV-LRRV--GE-PGTQ----MPKNFFD-----------------------D-KVN GS--E-----------------RV--LG-------------------------------- -----MIW---------------------------------------------------- ----------------------------------------------------------SH VRPFTFAGVDLCGPFL-------------------------------------------- ----------------------------IR--HG-R-----S-LV-----KR-WVM---L -FTCLT--VRAIHLEIVYTLSAESC-----KLGFRRF-IALR-GSPQEIYSDCGTNFQGL SNELK-A-E------IAA-IDQ-E----------------------LA---TTFTNTNTK ----WHFNPPAAPHMGGVWERMVRSVKTALST-IS--T---C-RNP----DGETF----- --ETF-----LAEAMAIVNSRP--------LTH------------V-------------- ----------------------PL-------------QA--------------------- ----------- >1125/1-533 ----TKRIVLRQLASMFDPLGLASPSLLSAKLFFQS-LWT-KE----------N------ -KWDD-K-ISD--ENAIKWKEITNSWIV-D---P-IEIN--RRV--T------------- ------DIKSK-K-QLHA-FSDASKC-AYA-ACIYIK--SEFEGK--------IHT-Q-- ILYA---------------------------RNRL-KPR--K----SE------------ --------------------------------VTIPRMELLGVV-IAK-RALEFVEKQ-- -I------G-VEIK---DK---FL---------WC------------------------- -------------------------------------------PV-------INT--K-- -KV-RIVYDASAKMR-EG---KSLNECLYRGPIIM--PDLAGLLIRFR---VPKI--AMW ADIEKAFHTLELEEE--DREVTK-----F------IWVKS---T-KK----PISTQNI-Q YLRFVKVPFGVISSPFLLSAT-VRHH------------L------KKCDD---P-VA-KI A-KEN--SYVDNI-FIGVE-S---ANEAWLAYKRLK-EI-FIDA-------QMNLR-EFI SNNM-EL-NERFPLEDR--L---------------------------------------- EKNKP-----------------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------RQ SRPFEFVGVDYLGPSM-------------------------------------------- ----------------------------CKI--DGGKV------------KF-WIA---L -FTCLS--TRGIHLDLITDLSALSF-----LDILRRF-VAQR-GAPVKIISDNGNQFITV AKIIN-A-------NIEGKWKK-EK---ANNE-----------EKIFN---NFLLEKEIE ----WKFIPALSPWQGGVYERLVKLVKDSFKRSLG--S-----RIL----NIEEL----- --RTF-----IKEVEMSINCRP--------ISY------------I-------------- ----------------------SV--------E-K------------------------- ----------- >1129/1-549 ---YTKRIILSQTSSCFDPLGLLGPAIVKAKILLQT-LWKL-D----------Y------ -DWDH-P-LPR--AFANEWEDYXQRFDQLK---T-FRFP--RHV--R------------- --SLRR-LA--TV-EVHG-FSDASEH-AYG-ACLYLR--SIAP-DG------YVTI-R-- LLAA---------------------------KSRV-APL--S-N---------------- --------------------------------KTIARLELCAAL-LLS-RLLLSVCTS-- -I-G----V---L---ENI---FL---------WT------------------------- ---------------------------------------LPHHAI-------LRLD-STT TKL-RIVFDASCKSG-SG---LSLNDILMTGPTIQ--DTLNDIVLRFR---MPAF--VIM GDLCKMYRQILHHSP--DQRLLR-----I------YWRQH---S-SE---------PL-K VFQLLTVTYGTSSAPFLATRV-LQQL------------A----EDE-QERF--P-LAAAV I-RKD--MYMDDL-LTGCN-D---VEKLKQLCSQLL-GI-FESA-------GMQLR-KIS SNHQ-EI-LNEIPEECRETKS--L-I-EF----------------------------D-- SDAPV-----------------KA--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TQ SYAFENVGVDFAGPFY-------------------------------------------- ----------------------------LQRP--SPRS---APK------KS-YVA---V -FVCMA--TKATHLELVSELTTAAF-----IGCLRRF-VARR-GRPQHIYCDNATNFVRS GRE-----------MRNLFRSS-NH------------------RHSVT---NETASQSIQ ----FHFIPAKSPNFGGLWEACVKSMKHHLRRVIG--N-----AFL----SREAF----- --CTV-----IAQVESCLNSRP--------ITP------------L-------------- ----------------------SN--------DPN--D-------M-------------- ----------- >113/1-579 ---PTKREILRVLMTIFDPLGLIAHFLMFLKILLQE-VWRS-G----------V------ -QWDD-P-IQA--ASYDKWKQWLQVLPQVE---Q-TRIP--RCF--R------------- -IHTSLD-VAYDA-QLHV-FVDASEN-GFS-AAAYLR--FLQ--AS------VVEC-T-- LVAA---------------------------KTRV-APL--K-F---------------- --------------------------------TSIPKLELQAAV-VGT-RLAKTISES-- -L------S-VPI---SRR---VF---------WS------------------------- -----------------------------------RIWYLPIFPV-------TNPN-K-P GKI-RIVWDAAAT-A-FG---KSLNSALLKGPDQL--CSLFSILLQFR---EHRV--GLT GDIREMFHQVNIREE--DQHCQR-----F------FWTDE---N-GN---------I--Q TFVMCVMTFGACCSPSCAQYV-KNVN------------A----ERH-SQEY--P-RATEV I-IKK--HYVDDM-LVSVE-N---EQEAIQLANEVK-LV-HDNG-------GFEIR-NWI SNSS-HV-LKAL--QG---GNVP---EKNLAL-----------------------SSE-L AT--E-----------------KV--LG-------------------------------- -----MWWSDTFFKVGWNRHDK-------LGQRCPTKREILRVLMTIF------------ ----------------------------------------------------------AF SRPFTHVGVDYFGPIN-------------------------------------------- ----------------------------VL--VG-R-----R-IE-----KR-WGM---L -ATCLT--IRAVHIETVHTLNTASC-----IMALRNF-IARR-GTPRVIYSDRGTNFVGA SRELR-D-------VEAAINEP-E----------------------IM---KEFVSTETE ----WVFNPPAAPHMGGSWERLIRTVKNNLMSISP------S-RTL----RDEEL----- --KNF-----LIEVENTINSRP--------LTH------------V-------------- ----------------------PI-------------DT--------------------- ----------- >1130/1-520 ---FTRRGVLSTVNSIFDPLGFVSPVTIQGKLIMRE-LNNQ-N----------D------ -DWDA-P-LPK--EMEEKWETWRQSLIDLK---N-LNIP--RCY--T------------- -NISPST--ATQR-ELFI-FSDASTK-AIA-AVAYLR--LTDS-FG------VSQL-G-- FVMG---------------------------KAKL-S----P-E---------------- --------------------------------QTIPRLELCAAV-LAV-ELAEFITSE-- -I------D-MHL---DDI---AY---------FT------------------------- -------------------------------------WYLPLFGV-------YHPK-K-P GNI-RVVFDSSAR-Y-ED---VSLNDVLLSGPDMN--NTLVGVLMRFR---KEAV--AIT ADIEQMFYGFLVRED--DRNFLR-----F------LWFRN---NDPS---------EDIV EYRMRVHVFGNSPSPAVAIYC-LRQS------------V---------KDG--DPDVRSF V-NRD--FYVDDG-LKSLP-T---EKAAIDLLKNTQ-RI-LAGS-------NLRLH-KIA SNST-EV-LKA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SM DPPFTNVGLDVFGPWD-------------------------------------------- ----------------------------VV--AR-RTRGGHA-QS-----KR-WAV---I -FTCQS--VRAVHIELIESLDTSSF-----INALRRF-LAIR-GPVKLIRSDRGTNFVGA CRELN-I-------LSN-IDKT-S----------------------VE---KFLLDQSCV ----WQFNPAHASHMGGSWERMIGLARRILDAMLQ--QL--GPSAL----THEML----- --STL-----MAEVTAIINARP--------L--------------V-------------- ----------------------PV-------------SS--------------------- ----------- >1131/1-563 ---PTKRIVLRAIMSLFDPLGLVAPVLIHGRMMMQD-LWRD-N----------L------ -GWDD-E-LND--AQQHTFKRWTGLLPGIQ---R-VKIP--RWY--F------------- -RGAAPN-ADNVV-QLHI-FTDASEL-GYG-CAAYFR--MQTA-DG-------VHC-A-- LIMA---------------------------RSKV-APL--Q-H---------------- --------------------------------LTIPKLELQAAL-LGA-RLKRTICDS-- -H------D-IKI---DAT---YF---------HT------------------------- ---------------S---------------ACQGRTWYLPLNVV-------GHPQ-K-P EKK-RLVWDAAAK-V-NG---VSLNSQLLKGPDLL--VQLPAVLCKFR---QRKI--AFG GDIEKMFHQIRIRKE--DTHSQR-----F------LFRFN---K-NE---------S-PK VFIMDVATFGATCSPCSAQYV-MRKN------------A----EEH-TKEF--P-EASAA I-INN--TYMDDY-YDSCD-T---IEEAIQRVKEVK-NI-HGQA-------GFNMR-NWV SNQP-SV-LPSL--GE-----SASDKNKKI-N-----------------------LCEET KH--P-----------------RV--LG-------------------------------- -----ILW---------------------------------------------------- ----------------------------------------------------------PY IRPFCSVGIDYLGPLD-------------------------------------------- ----------------------------VV--NA-R-----R-SE-----KR-YVA---V -FTCLV--TRAVHLEVAHSLSTESC-----IMAIRRF-VNRR-GPPKEIFSDNGTNFVGA SNELT-R-Q------LKD-INY-S----------------------CA---ETFTNTDTR ----WVFNPPSAPHMGGVWERMVRSVKDAMQA-LD--D---G-RKL----NDEIL----- --LTA-----LAGAESLINSRP--------LTY------------M----PQSNSNVEAI TPN----------------------------------HF--------------------- ----------- >1134/1-532 ---ATRRGILSVLNSIYDPLGFGSVVLQPMKVLLQK-LCKL-Q----------L------ -EWDD-P-IPP--NEKAKWDKWVTELPSLS---Q-FQIP--RCY--K------------- -PQHFND--VINV-QLHH-FSDASEE-AYG-TATYLR--LTND-VG------NIHC-S-- LVCG---------------------------KTRL-VPI--K-H---------------- --------------------------------LTIPRLELCAAT-IAA-RCDKLLRKE-- -L------Q-MTV---HSS---VF---------WT------------------------- ---------------T---------------GPVGRTWYVPHHGV-------YHPD-K-P NKI-RVVFDCSAK-Y-KG---VCLNDNLLQGPDLT--NSLVGVLHRFR---REKV--AVM GDIKSMFHQVRVSEP--DRDLFR-----F------LWWKD---GNLQ---------NELE VYRMSVFIFGTICSPSCANFA-LRRT------------A----EDH-EHQF--PPLVADT V-KNS--FYVDDC-LTSCS-T---GQEAIELVKHLR-EL-LAKG-------GFQIT-KWI SNHR-EV-IMSV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PN LPPFSYVGVDLFGPFL-------------------------------------------- ----------------------------VR--KG-R-----S-DL-----KR-YGV---L -FTCLT--IRAVHIEVACSLETSSF-----LQALRRF-IARR-GQVLEMRSDNGTNLVGG ERELR-E-------SIEQWNQS-Q----------------------IS---DFLMQKQIK ----WVFNQPTASHHGGIWERQIRTVRKVLGAVCK--E---Q--RM----DDETL----- --TTL-----MCEVEAIINGRP--------LTT------------V-------------- ----------------------SD-------------D--------PGDL---------- ----------- >1137/1-550 ---ATKRNVMGAIARIYDPLGFVDPVKMVAKIFMQK-LWKL-K----------D-VNGIS WPWDK-E-LPE--DLCREWTNFATQLHVLQ---D-VKLP--RLV---------------- --CSSE-----TI-EYHI-FCDASER-GYG-ACLYVR--NVDP-SG------AAKV-Q-- LLIS---------------------------RSKV-APL--A-K--R------------- --------------------------------LTIARLELCAAL-LGS-RLWDFARKG-- -RLR--------G---GPC---FL---------WT------------------------- -----------------------------------IQYYLPHHAV-------WKLD-STT TKC-RVVFDASCKTD-SG---RSLNDILFTGPQLQ--DDLVSILLRFR---FNKV--AMV ADVEKMYRQVLIDEK--DRELQC-----I------FWRSH---E-SE---------PV-G TFKLNTVTYGTACAPYLAIKT-LRRA------------F----EDG-ESEF--P-ASKR- W-YND--FYVDDL-ISGAE-S---ADQAKLIRQDVV-EM-LAKA-------GFKLR-KWA SNMV-EA-LKGIP-KEDLAKTDVH-VLNVG------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------TE ARPFAISGVDYCGPVW-------------------------------------------- ----------------------------IKAQ--HRRG---APT------KA-FVA---V -FVCFV--TRAVHLELVSDLSTPAF-----LAALRRF-VARR-GLVTELHSDNGTNFKGA ANELH-Q-------LYEMLCSL-KH------------------REEVS---AWSAENTIQ ----WKFIPPRAPHFGGLWEAAVRSMKFHLIRVLG--N-----ASA----SYEDM----- --TTL-----LTEIEACLNSRP--------ITP------------L-------------- ----------------------SD--------DPS--D-------F-------------- ----------- >114/1-539 ----TRRSILSVLNSVYDPLGFIAPVMLTGKGILQD-LCKL-N----------C------ -GWDE-T-IPT--AYTERWTEWLKDLNLIS---S-LRIR--RCL--K------------- -PQDF-E--VARA-QMHH-FCDASER-GYG-TVSYLK--HGSK-VG------LPHI-M-- FVIG---------------------------KSRV-APL--K-V---------------- --------------------------------VTTPRLELASAV-LAA-RIDRMLRRE-- -L------E-LTL---EDS---VF---------WT------------------------- ---------------S---------------RKDGRLWYIPHHGV-------YHKR-K-- KTI-RVVFDCTSS-F-QG---TSLNRELLPGPDLT--NTLLGVLLRFR---QEPV--AVM GDIEGMFHQVRIPKH--DVDFLR-----F------LWWPD---GDTN---------QPLA EYRMTVHLFGAVSSPSCANFA-LKRT------------A----DDN-EGKC--STDALNT I-RQN--FYVDDC-LKSVP-N---EGQAIRLVKELR-SV-CTTG-------GFKLT-KWT SNSR-AV-LASV-------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------V----------- ----------------------------------------------------------PD LPPFTHTGLDYFGPIE-------------------------------------------- ----------------------------VK--RG-R-----S-KV-----KR-YGA---L -FTCLA--SRAVHLEMAYSMDTDSC-----ISALRRF-ICRR-GQVKEIVSDNGTNFVGT ERELR-E-------ALTHLDLS-K----------------------IQ---HSMHAEGIK ----WTFNPPYGAHHGGVWERLIRMIKKNLYSITR--E---Q--IL----DDESL----- --QTA-----LCEVEAIMNDRP--------ITV------------L-------------- ----------------------SQ-------------DAKDPEPLTPNHL---------- ----------- >1141/1-559 ---NTKHQLLSDSAKLFDPIGWLAPVTVRAKILFQQ-CWLY-D----------M------ -NWHD-P-LPA--AVEQMWIEFKENLPRLE---Q-VKIP--R-W--M------------- -SSYNGH--V----ELHG-FSDASEE-AYS-AVVYIR--TFNE-ID------GAYV-N-- LVAA---------------------------KTKV-API--R-Q---------------- --------------------------------VSLPRLELNGAW-LLA-RLMKRVAKA-- -F------E-RFK---VEM---FA---------YT------------------------- ------------------------------QADCTKSYYLPHHGV-------VKED-SST TKL-RVVFDGSCATT-TG---VSLNDLLLNAPNVN--ADLFDVLLRFR---TYPV--VFT ADVEKMYRQVWVHRD--DTDYQR-----I------VWRES---P-DE---------PI-R HFRLLTVTYGLKNSGFLAMSA-LKKA------------A----EDF-EQHY--P-GAAER I-KEH--TYVDDL-VSGAD-L---AAEAARLVEQID-EI-AGKA-------GFTLR-KWC SNVD-ET-LLPLADVKNAAVPIQF-PDERN------------------------------ ---AI-----------------KA--LG-------------------------------- -----IHWLPQED----------------------------------------------- ----------------------------------------------------------TA CRPFTHVGVDYAGPIQ-------------------------------------------- ----------------------------VRCS--NTRG---TRSM-----KG-YIV---V -FVCLS--TKAVHLEAVSDLTSQGF-----ISALKRM-IARR-GYCCEIWSDNGTNLVGA DRLLQ-E-------IYEAIMAH-SK--------------------EAE---QFLCNLGIK ----WKFIPPASPHQGGIWEAAVKSAKSLLRPVVG--N-----EKL----TFEEL----- --STV-----LCQIEACLNSRP--------LCP------------L-------------- ----------------------ST------------------------------------ ----------- >1149/1-557 ----TKRTVLSHIARLFDPLGLVGPVVTTAKIFMQA-IWTL-V----------D-DDEKP WSWDK-E-LPA--AFKDRWTSYQMQLPSLN---A-LRVQ--RCV--L------------- --LP-M-PT--SV-QIHI-FTDASEH-AYG-ACVYLR--STNS-NG------SVKV-A-- LLSS---------------------------KSKV-SPL-------K------------- ---R----------------------------QSIPRLELCGAL-MGA-QLYEKVIAS-- -L-R----I-K-----ADT---FF---------WV------------------------- -----------------------------------PCYHLPHHAV-------IRED-STT TKV-RVVFDASCRSS-SG---PSLNDALMVGPTVQ--EDLRSITMRSR---IHPI--LLN ADIKQMYRQILTDES--SNRLQH-----I------VWSPS---P-DA---------PL-Q TYELKTVTYGTASAPYLATRV-LQQL------------A----DDE-QNEY--P-EAAEV L-RND--FYVDDL-FSGAK-T---TDEAITLREQLE-KL-LKKG-------GFELR-KWA SNEP-AV-LEDVPIENRALKP--S-V-DLE---------------------------K-- -DQCI-----------------KT--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA TQPFAVTGIDYWGPIQ-------------------------------------------- ----------------------------IQPQ--HRRA---SPR------KA-YVA---V -FVCFC--TKAVHLELVADLSTSKF-----IQALRRF-VSRR-GLCSDIYSDNGRNFVGA AKELR-H-------L---LRSQ-EH------------------KAAIA---QECTKNGIK ----WHFNPPTASHFGGLWEAAIASAQKHFARVLG--P-----HIL----AFDDT----- --ETL-----LAQIECCLNSRP--------LVP------------I-------------- ----------------------SD--------DPS--D-------F-------------- ----------- >115/1-562 ----TKRIVVSDASKLFDPLGLIGPVVVEAKIFIQT-LWKL-N----------A------ -NWDD-P-LPE--NLQTFWLEYRRNLSALE---S-ISIP--RWV--G------------- --YTKE-CV--ST-EWHG-FCDASDS-AYG-ACLYLR--CTYA-DG------SVRI-Q-- LMMS---------------------------KSRV-APL--E-DLKK------------- ---KKRK-------------------------QSTPRLELSSAL-LLS-HLYEKTSKA-- -T-A----L---A---IPS---YF---------WT------------------------- -------------------------------------YFLPHHAV-------LKPD-STT TKL-RVVFDASCKTT-SG---ASLNDGLMVGPVVQ--DDLISIHARFR---LHRI--GIV ADVAKMYRMINMCPP--DQKLQL-----I------LWRAT---P-DE---------AI-E VFQLTTVTYGTASAPFLATRC-LVQL------------A----EDG-ESTH--P-VAAKV V-RKD--FYVDDM-ITGVD-N---PEEGKELVEEMV-KL-TDSA-------GMTLR-KWN SNCG-EV-LSELQPHLRD-RV--L-Y-EMD---------------------------SPP PTATV-----------------KT--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------NP APPFLKVGVDYCGPFL-------------------------------------------- ----------------------------VSYP--QRRS---GPV------KC-FVA---I -FVCLV--TKAVHVELVADLTTAAF-----LAALRRF-TARR-GRPAVIMCDNAKNFVGA KRELR-Q-------LLNLFEQQ-QF------------------QNAVA---SNAADEGIE ----FKFIPARSPNFGGLWEAAVKCFKNSFKKIVG--S-----RTL----LYDEM----- --QTV-----LPQIEAVLNSRP--------LTP------------L-------------- ----------------------SN--------DPG--D-------F-------------- ----------- >1151/1-544 ---PTKREVIAFSASNYDPCGLIAPILVLLKKLIQK-IW-EKN----------L------ -KWKD-K-LPA--ELMPMWKAVKEQFTDKT-----YELP--RQL---------------- ---T-TNYNFTSL-ELIM-FSDASKD-HYA-AVGYLR--FGY-DNK------HFVT-K-- LILA---------------------------KSKV-RPSKSGPE---------------- --------------------------------YTIPRMELISME-LAS-NAAIMLSKE-- -L------H---TKI-KKV---TL---------FS------------------------- -----------------------------------PIYYAPTGVV-------IKE-DSST TKL-RIVYDASAHGK-GD---ISLNECLFPGPALI--NQILGILMRSR---LGRY--VMF SDIEKAFHQIRIQKE--YRNTTR-----F------LWLKD---P-KL----GPTPRNI-V KYRFTRLPFGVACSPFLLAVT-ILLY------------C-------DIFPH--E-VN-ER I-KEN--IYVDNI-MFIAF-S---EEELMELYKKSK-EQ-ARRM-------HMNLR-EYM ANSS-EV-MKNIPEEDR--A---------------------------------------- ANTYC-----------------KV--LG-------------------------------- -----HIY---------------------------------------------------- ----------------------------------------------------------TL VGPFKYIGLDYLGPLY-------------------------------------------- ----------------------------YNTTTS-ESG------------KV-WVL---L -ITCLV--TRAIHLEVVTCNTSLGF-----IDGLKRF-IGRR-GKPTSILSDNAPQFKLG YAIIN-H-------DLKT----------TVNN-----------SATLT---SYLAQNEID ----IKNTTPFSPWQGGIYERLIALVKNLINKVLG--T-----KKL----SFLEL----- --ETL-----IIETEGILNSRP--------ITP------------N-------------- ----------------------K--------------------------I---------- ----------- >1154/1-540 ---ATRRGILSTVCSLFDPLGCASPVLLPAKHLLQT-LCRL-G----------L------ -GWDE-T-IPP--DLLKKWETWKRELPRLS---D-FKLS--RCL--K------------- -PEGYEN--PKSV-TLHH-FADASEK-GYG-TVSYLR--MVNT-RD------EVQC-S-- FLLS---------------------------KSRV-APL--K-Q---------------- --------------------------------TSIPRMELTAAT-VAV-RIDKMVKQE-- -L------D-IPV---DET---FF---------WT------------------------- ---------------L---------------REDGKMWFIPHHGV-------YHPQ-K-- QKI-RVVYDCAAS-F-KG---KSLNDNLLQGPDLT--NSLVGVLTRFR---QDRI--AVM ADIEAMFSQVKLLKE--EKDLHR-----F------LWWPD---GNVA---------QPIE EYRMTVHVFGARSSPACANYA-LKRT------------A----EDF-AED-----KVTHI I-KRN--FYVDDC-LYSSS-T---VQEAAELSEGLQ-EA-CKKG-------GFHLT-KWV SNDK-RV-LNAI-------PKEERASTVQEL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PD DPPFTRVGVDYFGPIG-------------------------------------------- ----------------------------VK--RG-R-----S-TV-----KR-YGV---V -FTCLA--IRAIHIEKADSLDTDSC-----IAAIRRF-IARR-GAVREMRSDNGTNLVGA EKELR-K-------ELESWNQA-Q----------------------LS---NSLLQVNIK ----WTFNPPGGSHHGGVWERQIRTIRQLLFFLTK--Q---Q--TM----TDESL----- --QTL-----FCEIEGIINCRP--------ITR------------V-------------- ----------------------SD-------------D--------ANDL---------- ----------- >1155/1-522 ---TTKRKMISDINSIYDILGWSSPVTITAKLIFSE-VCLL-Q----------L------ -HWDE-R-VPE--GIHKKWWMWIKSLQLAP---T-ITIP--RCV--F------------- ----TDT--PTSF-EIHG-FADASKV-ALC-AAVYVV--ACRD-SK------PVSQ-Q-- LLVA---------------------------KSRI-APK--D------------------ --------------------------------RSIPRLGLAAAH-TLA-KLQNNVSKA-- -L------AAFPI---TA---------------WN------------------------- ---------------------------------------VPHQAV-------IRE-KAET TKM-RIVYDCSAKAN-TK--SPSLNDCLETGPSLQ--PLLFDIMIRNR---MRKY--CIT GDIQKAFHQIRVHEQ--DRDAMR-----I------LWYNK---L---QD------RQL-M EYRFTRVIFGATSSPYILGVT-LQKH------------I----ENYRENYP--I-TV-QT L-LDD--TYVDDI-QGGGE-T---EHDVAVFKEEST-KI-LSEG-------GFSLH-KWH SNIT-HL-SSK------------------------------------------------- ---------NNI----------KH--EG-------------------------------- -----TDN---------------------------------------------------- ----------------------------------------------------------EF TEPFDVTGVDFAGPLH-------------------------------------------- ----------------------------YKL--G--KS---ETN------KS-YIA---L -FTCAT--TRAVHLKLCRDMSTVEF-----KRGLKEF-VARR-GSPSCMVSDNAKTFVAT KMWLT-K-------LQND--------------------------EDIF---NYLTTKGIE ----WRFNLSRSPWWGGFFERLIGITKRALSKTIG--R-----ALL----TFEEL----- --EEV-----LLDVEVFMNNRP--------LCY------------M-------------- ----------------------EE--------D--------------------L------ ----------- >1158/1-550 ---PTKREVLKIVMSLFDPLGFASFFLVHGKVLIQE-IWAS-G----------S------ -HWDQ-P-IKD--EICERWHRWTEMFDQLV---K-LRIP--RSY--F------------- -SSAIPT-EFNNL-QIHI-FVDASEA-AYS-CVGYFR--LDS--ES------GIQV-S-- LIGA---------------------------KTKV-APL--K-T---------------- --------------------------------LSIPRLELKAAV-LGA-RFMESIQAN-- -H------T-FHV---SQK---YY---------WS------------------------- ---------------S---------------SDPSRVWYLPLGIV-------TNPK-K-P DKI-RLIWDASAK-S-DG---VSLNSKLLKGPDLL--TPLPTVLSRFR---QYPV--AVS GDIREMFHQLTVIEP--DQQAQR-----F------LWRED---P-AG---------E-PH IYVMDVLTFGSTSSPSSAQYV-KNLN------------A----SEF-ASEY--P-RAAGA I-LEN--HYVDDY-LDSFA-T---VEDAIRTVNEVK-HI-HSKG-------GFQLR-KFK SNEV-AV-LRGI--GEL----ANDE-CKDLLL-----------------------E-RGE SI--E-----------------SV--LG-------------------------------- -----MKW---------------------------------------------------- ----------------------------------------------------------TF ERPFTFVGLDYFGPVL-------------------------------------------- ----------------------------VR--VG-R-----S-TA-----KR-WIA---L -FTCLS--IRAIHLEVVHSISTESC-----IMAVKRF-VARR-GPPVEIYSDNATCFQGA SNELQ-R----------E-IND-A----------------------LA---LTFTSTNTS ----WKFIPPAAPHMGGVWERLVRSVKVAIASINE--S---C-RKP----DDETL----- --ETI-----VLDAEAMVNARP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >1159/1-522 ------DFVXMIAHRVFDPIGFTTPVTLLPKLLLRE-LWKSKK----------------- -DWDS-P-VDK--DTEQRFHNWVKQLHYLK---N-IAIP--RKL---------------- --------GTGNV-SLHT-FCDASQV-AYA-AVSFLR--IEN--KG------NVEL-R-- FITA---------------------------KARI-APE--K------------------ --------------------------------ATISRLELLAAS-IGS-RQARDIIDA-- -L------E-YDD---VPV---FY---------WS------------------------- -------------------------------------HYLPNRPV-------IKE-GS-T TEI-RPILYASAAEK-DK---PSLNNCLEKGPNLI--ELIPTALLRFR---EHEI--AVL VDIRKAFLQIEINEK--DRDYLR-----F------LWY-------------V--DGEL-K SFRHRRVVFRLTCSPFLLGAV-IKLH------------ISNILNDPNHKWS--T-KAITK L-AKS--FYVDNC-LASVK-S---VEELDLFTSTAK-EV-MKNG-------SFDLR-GWE YTRD-SS-EKR------TT----------------------------------------- ----------------------SV--LG-------------------------------- -----LLL---------------------------------------------------- ----------------------------------------------------------II EKC--VTGVDFAGPLF-------------------------------------------- ----------------------------LRE-----------GR------KA-WIC---L -YTCAV--YRAVHLELVTSLSTLEF-----LSSFCRF-IGRR-GRPVTMYSDNGSNFVGA NNLLE-D-------LNW---------------------------DTIS---QYSCAQRIE ----WRFNPPTAAWWGGWWERLIGMLKNILRKVLG--K-----ACL----TYEEM----- --CTV-----LCDCENTLNSRP--------LTY------------L-------------- ----------------------SD--------ETN--D-------LKPLTPAMF------ ----------- >116/1-586 ---PTKREMLRVLMTIFDPLGLIAHFLAYLKVLLQD-VWRS-G----------I------ -TWDE-E-IDD--DAFEKWQHWLSVLPQVE---K-LQIP--RCL--W------------- -PRHLID-TADDV-QLHT-FVDAGKD-GMA-AACFLR--FLK--NK------EIYC-S-- LVTA---------------------------KARV-APL--K-L---------------- --------------------------------TSIPRLELQAAV-IGT-RLSRTVLDT-- -L------S-IRI---TQR---FY---------WT------------------------- -----------------------------------NAWFLPVFPV-------TNPN-K-P GKV-RIVWDAAAK-V-HG---VSLNSVLLKGPDLL--CSLLGILLRFR---LHPV--AVT GDIREMFHQVNIRQE--DQKYQW-----F------YWTDE---K-GE---------L--V IYTMTVMTFGACCSPSSAQYV-KNVN------------A----DRF-IGSH--P-EACEA I-TKS--HYVDDM-LISVA-T---EEEAIQISKDVR-HV-HAQG-------GFEIR-NWI SNSK-NV-MEAL--QE---QSVD--NEKSLDL-----------------------STE-L AT--E-----------------KV--LG-------------------------------- -----MWWNTTADAFTYKIGWNRYDDLL-KGDRRPTKREMLRVLMTIF------------ ----------------------------------------------------------AF SRPFTHVGIDYFGPIE-------------------------------------------- ----------------------------VV--VG-R-----R-HE-----KR-WGM---L -TTCLT--TRAIHIEVVNSLSTDSC-----IMAIRNF-IARR-GQPRKIYSDRGTNFVGA DRELQ-R-------LQSAINHD-E----------------------MM---REFATEQTE ----WVFNPPLAPHMGGSWERLIRTVKNNLMAVCT------T-KSL----TDEVL----- --RNL-----LVEIENVVNSRP--------LTH------------V-------------- ----------------------PL-------------DE--------------------- ----------- >1161/1-543 ---PSKRQVLRCVMTLFDPLGLLTPFLIHGKVLIQD-LWRS-G----------T------ -GWDE-P-IGD--LQYERXRRWVEMIEFVS---T-VEIP--RCY--F------------- -PSATED-MYAEA-ELHV-FVDASPT-AYA-CAVYLR--ATDQ-DG------IVRC-T-- LVAG---------------------------KAKV-APL--K-P---------------- --------------------------------MSIPRLELQTCV-LGT-RLLKFVQDG-- -H------T-IQA---KSR---VF---------WT------------------------- -------------------------------------WYLPLGVV-------TNPN-K-P GKV-RVIWDASAK-A-GG---VSPNNMLLKGPDEL--TALPAVLFRFR---QFGV--AVN AYIQEMFHQVRIREE--DKFAQC-----F------LYRKN---K-TQ---------P-ID VFLMDVATFGATCSPASAQYV-KNRN------------A----MEH-AEQY--P-RAAEG I-LHC--HYVDDY-LDSFG-T---EEEAKKVAADVR-QI-HRNG-------GFHLR-NWN SNST-EV-LRHL--EEP----KAME-NKNLXF-----------------------G-DSE SK--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------VH VRPFSHVGLDYFGPLL-------------------------------------------- ----------------------------VK--IG-R-----S-NV-----KR-WVA---L -FTCMT--VRAVHLEVAYSLSTSAC-----ISCVRRF-VGRR-GSPVEFITDNGTNFQGA ERLLR-E-Q----------INQ-G----------------------LS---STFTNSATK ----WTFIPPGAPHMGGAWERLVQSVKKATLDA-F--A---E-GNL----ADEGL----- --QTL-----VVEAESIVNTRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >1162/1-536 ----TKRTSLKSIASCYDPLGLLTPVTLHGKLFFQQ-LAT-AN----------N------ -SWDL-P-LSQ--CQHESWNKVCEKWKG-T---E-WRIK--RQL--F------------- --SEDFNLNSDQI-ELHL-FTDASQA-AYG-CVAYLR--ILNTDGK-------AAS-R-- ILIS---------------------------KSRV-API--S------SK---------- --------------------------------YSIPQLEALGIL-TGV-RLGNYCIEQ-- -L------G-LQIK---QA---YL---------WT------------------------- -------------------------------------SYLPHHPV-------IKE-SSST TKV-RIVFDGSARSN-KS--IQSLNDHLQTGERLL--PDISAILLRIQ---QHSI--LIS GDIEKAFLQLSLHVS--DRDATR-----F------LWK-------------DPTNGRI-I CYRYCRVPFGLKPSPYLLNKT-VRTH------------L-------KSYDH--P-WA-QI M-VNS--FYVDNV-FMGLD-S---TTDAKQFYVFVK-KL-FADA-------QMNIC-QFV SNSP-EV-NEFFAENE-QKPV--------------------------------------- LDRIQ-----------------KL--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------LP SRPFQFCGTDYAGPLL-------------------------------------------- ----------------------------VKIG-NSP--------------QKIWII---V -FTCLY--SRYTITEVVTDMSTHAY-----LNALRRL-SSLF-GTPKQLLSDNASQFQLL GAVFN---------HVKNTMSTNV---------------------------NNIDSTTFP ---AIHFLTPHSPWEGSVYERIVSLIKRALLRAGS------STTLF----ELDDF----- --RTI-----LMECVSVINMRP--------LTY------------Q-------------- ----------------------S------------------------------------- ----------- >1163/1-545 ---PSKRNALSCIMSLFDPLGLLALYIVHGKMIIQG-LWRS-G----------C------ -LWDH-T-IDD--DSMKKWSRWIALLPEVQ---S-MRIP--RCY--F------------- -SCASPS-DYENL-QLHV-FTDASED-AFG-CVAYFR--VLVN-GQ-------PRC-A-- LVSA---------------------------KSKV-APL--Q-H---------------- --------------------------------LSIPRLELQAAV-LGA-RLSASVKDN-- -H------S-VQV---KRL---FL---------WT------------------------- -------------------------------------WYLPLSVV-------QHPK-K-P GKI-RLVWDAAAS-V-GG---KSLNSELLKGPDFL--TSLPAVLSPFR---ERPI--AFG GDIMEMYHQVLIRPN--DKSAQR-----F------LFRPN---G-SA---------S-PV IFTMDVATFGSTCSPSTAQYV-KNYN------------A----KSY-AERF--P-DAVEA I-IKK--HYVDDY-FDSTD-T---AEEAITRAQEVA-FI-HAKA-------GFKIR-NWV SNNV-EF-QRYF--GE-----NGDNQVIHFNS-----------------------D-KIT GT--E-----------------RV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PQ LRPFSFVGIDYFGPVT-------------------------------------------- ----------------------------VA--IG-R-----R-SE-----KR-WIC---L -FTCLV--TRAIHMEVAHSLSSQSC-----IMAIRRF-SCRR-GAPLEFFSDNGTNFQAA SKEIV-Q-D------VRK-IVL-E----------------------CA---EVFTDARTR ----WNFNPPSAPHMGGTWERLVRSAKEALKA-LH--D---G-RKL----CDEIL----- --LTV-----LAEAEDMVNSRP--------LTY------------V-------------- ----------------------PQ-------------ES--------------------- ----------- >1167/1-546 ---PTKRDVASKLAETFDPLGLVSPIQVPFKRLMQR-TWQQQG----------S------ -DWKA-P-LPN--ELLQDWRALRTAFIDRV-----ITVR--RPL---------------- ---T-PDYSDSRI-ELLM-FSDASHD-IYA-ALCYAN--FIR-DGQ------PPVT-Q-- LLAS---------------------------RNKV-KPSKEL-K---------------- --------------------------------WTIPKLELLGIV-CAS-NLARSIITE-- -L------R---VPI-AKV---RL---------FT------------------------- --------------------------------------YFPHRGV-------VKA-DSMT TKL-RIVFDASSHAS-GQ---LSLNDCLHAGTNMI--VPLFGILVRFR---VPRK--VIV GDIEKAFHQIPLQEE--FRNLAM-----F------LWVKD---V-NK----PPTRDNI-E AYRFKRVPFGMTSSPFLLAAS-INYQ------------L-------DNNPH--E-LN-EE I-KEN--LYVDNC-MFCTN-D---ESAIPRIVSEAK-QV-FNRL-------GMNLR-EFI TNSP-EA-MAAIPEADR--A---------------------------------------- KSDVI-----------------KL--LG-------------------------------- -----YKW---------------------------------------------------- ----------------------------------------------------------TP SKPFSKVGLDYYGPIV-------------------------------------------- ----------------------------YLRDDRKSYG------------KA-YVL---I -YTCLA--TRGALLRLVPNANSETY-----VKTLKMI-FTEV-GVPSEIYSDNAGTFKLG AAIIN-K-------DIDH----------FV-Y-----------SNTLT---QFLATTSIT ----CRYITPLAPWQGGIYERIVQLVKRQVLKECG--S-----RVY----EYHDL----- --SYV-----ISGAQGMINNRP--------LIP------------H-------------- ----------------------AR--------SPG--D-------L-------------- ----------- >1169/1-546 -----RRTVSSVIHGIFDPLGSLAALVLPMKLFQRE-LWMD-E----------------- YDWDT-P-LNK--EHEIQWQQLVEDIQGFS-----KRIP--RHV--I------------- -SKSLNN-------KLVT-FTDASKE-ATA-WTIYVV-------NE-------MGC-H-- LIYA---------------------------KSKV-KPLKEI------------------ --------------------------------WTIPKLEMQALE-MGT-VNTLKTIEF-- -LKLGNINV-------NEI---NI---------FT------------------------- ---------------------------------------NPHQPV-------FTP-TKTT TKC-RVVVDGSAHFK-NK---PSLNDQIHQGPTIL--PDLMGMLLRFR---SGKT--AVT SDVEKAFLQVYLHED--DRDATR-----L------LWVKD---I-NK----DFTGDNI-M VLRFTRVLFGLNVSPFLLAAT-INHH------------L------ETINDQ--D-MA-RE M-SNN--LYVDNL-LMTTDKD---PGNIIKLYSGPK-ET-FNEM-------GMNLR-EFT TNSK-EL-REMIPEKDA--S---------------------------------------- EETTP-----------------KV--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------TK TRPFGNIGIDGFGPID-------------------------------------------- ----------------------------YKGP-DGTTQ------------KA-YGI---I -YVCMV--TRATHIEVVTDQRASSF-----LQSLRRF-IGIR-GMPTKILTDNGKNFTLG SKIVK-D---------AI--D-------SSDL-----------TEEVR---NFLRIRDIE ----WKFITPLSPWKGGMYERMVKIAKQSFMKERR--L-----QKL----NLEEL----- --QTV-----FHEVAAMMNDRP--------LTY------------P-------------- ----------------------DN--------EIG--T-------QNPIRPSDF------ ----------- >117/1-544 ---PTKREMLRLVMSIYDPLGLVASFVIHGKVLIQD-VWRT-E----------T------ -DWDS-K-IPT--EIAERWIEWIAVLKRMN---G-LRIP--RCY--F------------- -PGYDPE-SYKNV-ELHV-FVDASAQ-AYA-AVAYFR--IFD--QG------QFRV-A-- LVSS---------------------------KTKV-APL--R-G---------------- --------------------------------LSIPRLELMAAL-LGS-RLRKTIEEN-- -H------S-LKI---QRT---CF---------WS------------------------- -------------------------------------WYLPIGIV-------INEK-K-P GKV-RVIWDAAAK-V-DG---TSLNSMLLKGPDLL--TPLLSVMFPYR---ERQV--AVS ADIREMFLQISIRKE--DRSALL-----F------PYRDS---P-EL---------P-MS TMVSDVAIFGAACSPAHAQYI-KNMN------------A----DEQ-EAVF--P-RGAAA V-KKR--HYVDDY-VDSFD-T---AEEAVQVALEVI-EV-HKRA-------GFHIR-NWM SSDS-TV-LEKL--GE-----ANRKP-KNMLS-----------------------E-QNT AF--E-----------------RV--LG-------------------------------- -----MAW---------------------------------------------------- ----------------------------------------------------------PY VRPFTYVGVDLFGPYL-------------------------------------------- ----------------------------VK--IG-R-----S-VA-----KR-WVC---L -FTCLT--IRAIHLEVVTNMSTDAC-----KKAFRRF-IARR-GAPQEIYSDNGTNFVGA SRDLQ-D-E------INK-IYT-E----------------------LG---STFTNAQTQ ----WRFNPPAAPHMGGCWERMVRAVKSALGC-VP--V---E-RKL----DDESF----- --ATV-----LAEAESMINSRP--------LTF------------I-------------- ----------------------PL-------------ET--------------------- ----------- >1174/1-544 ---PTKRDIASFFAKTFDPMGYSAPLHVKIKKFVQK-IW-QNG----------L------ -EWKA-P-LTD--KLNKEWEIIKQQYKDTA-----LVIP--RKL---------------- ---RQKYHPDEKP-EIVV-FCDASQH-TYA-CAVYIV--YRH-PDG------SVES-N-- LIGA---------------------------KSKV-RPSSGA-G---------------- --------------------------------WTIPRLELLAME-IGM-RYTESLIHE-- -L------P-EKDKP-VSL---DI---------FS------------------------- ---------------------------------------APQNAV-------FKA-NSAN TKV-RIVGDSSSHQK-GQ---LSLNDCLFEGPNML--RTAPGLHLRHR---IDQY--PIV GDIARAFHQVRLQEK--DRNVTK-----W------LWVED---I-EK----PPTGDNL-V EYRFTRIPFGMKCSPFLLAAT-IRHY------------L-------LMAAS--I-LS-IE I-DKN--LYVDNI-MVSTN-Y---AEEVLPKIKGIQ-EE-FKVM-------SMPVR-EFG TNYH-PA-LLEIPEADR--A---------------------------------------- ESHIS-----------------KF--LG-------------------------------- -----YSW---------------------------------------------------- ----------------------------------------------------------VP STPFAKVGLDFFGPLQ-------------------------------------------- ----------------------------YKNRNETELE------------KG-YVL---I -YTCLT--TRCTHLEICADSSTTSY-----LNALKAI-FAQR-GVPKYIYSDNAQTFQLG ERVLR-E-------DIKS----------YE-P-----------ESRLI---NFLAREDIN ----FRHITPMAPWQGGVYERIVGIAKKQFRKEIG--K-----QIF----SFPEL----- --HSI-----MKRVEGAINSRP--------LIR------------N-------------- ----------------------PV--------HI-------------------------- ----------- >1177/1-600 ---NCLSHTSESVRSA----RYIIPFTTRAKILVQT-LWKR-V----------K------ -DWDE-P-LPA--DLLLEWRAWEEELPNLQ---K-ITLP--RCY--M------------- -PA-CNS-ISSIL-DIHA-FFDASEK-AYG-AVAYLR--AELD-S-------HTQV-A-- FIMA---------------------------RSRV-APK--R-Q---------------- --------------------------------LSVPRLELCAAL-SGA-QLAKTLNTE-- -V------T-LTI---RHT---IM---------WS------------------------- ---------------K-------------------ESXFVSHHIV-------QHN----- SKH-KVVFNCSFS-H-NQ---INLNENLLPGPTLG--SPLLGVLLRFR---QYSI--AIS GDIRAMFHQIRLLPE--DQPLLR-----F------LW-RD---MERD---------RSPD IYEWXVLPFGTTCSPCCATYA-LQKH------------V----RDN-SDG---NEEVVEF V-QQS--FYVDNC-LQSFP-C---QQQAKKLIDKMR-AL-LKTG-------GFNIR-KWA SNVP-EV-IAHL-------PSDAKSERFELWL-----------------------SESKT -DPQE-----------------SA--LG-------------------------------- -----LMWQCLQDKFSYKPRFTSTDGATSMRTVYRILASQYDPLDTLFPSPREPKSWCKH FGSEL-----------------------------------------------------ID QPPFWSTGMDCFGPFT-------------------------------------------- ----------------------------IR--LG-R-----R-HE-----KR-WGI---I -FKCLT--TRCVHLDLLCSMDSDSF-----LIAFRRF-IARR-GRPFELISDRGINFRGG ERELS-E-------AFAEMEQP------------------------LC---EQLAKQKIS ----FRYNPPHAPHFGGAWEKEIKSVKAALQVVLQ--D---Q--VV----SEEVL----- --NTV-----LIEVKRILNSKP--------LGY------------V-------------- ----------------------SS-------------DI--------------------- ----------- >118/1-542 -----KREVLSQIARLFDPAGWLAPFVIRAKIFMQE-IWLQ-Q----------L------ -GWDD-P-LPA--ELMGKWNEFLMSYPTIN---Q-IRIP--RWV--K------------- -FGPQS-----KV-QYHG-FCDASQQ-AYG-AAIYVR--IEHA-QE------V-SI-S-- LLTA---------------------------KTRV-APV-------K------------- ---T----------------------------MSIPRLELCGAV-LLA-ELFQSVVPQ-- -L------P-PDD---FDT---FY---------WT------------------------- -------------------------------------FYLPHHAV-------FKPD-STT TKV-RVVFNASCPTS-NG---KSLNDILHPGPVLQ--SDLTLQVLRWR---FFRF--VFN ADITKMYRQILVAPE--HTPFQR-----I------LFR-D---A-ND---------QI-C DYELKTVTFGVNCAPFLAIRV-LQQL------------A----KDV-RTTF--P-LASEI I-STS--MYVDDV-LAGAH-T---KQSAGVAIEQLR-AA-LRSA-------GFPLR-KWT SNSK-CI-LKDIPKDHLLREG----FLELD------------------------------ DQSTA-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------TF SRPFTHTGVDFAGPFE-------------------------------------------- ----------------------------IKNY--TGRA---CLIT-----KG-YVC---V -FVCFS--TKAIHLEATSDLTSEKF-----LAAFARL-AGRR-GCPQKLYSDNGKTFVGA SAIITRD-------FLQAT------------------------REMVT---AHYSHQNLS ----WYFNPPSAPHMGGLWEAGVKSFKAHFYKSAS--S-----VKY----TFEEL----- --STL-----LIKIEACLNSRP--------ISP------------M-------------- ----------------------SE------------------------------------ ----------- >1181/1-544 ---PTKRQVSSCVMSFFDPHGYLSPLTIHGRLIIQD-LWRS-G----------C------ -AWDD-M-IDD--ESAYKWKRWTAAMPTIE---A-LKIP--RCY--F------------- -SSICSL-DHETL-QLHI-FTDASEN-AYG-CVAYLR--AVVD-GL-------PRT-A-- LVAS---------------------------KAKV-APL--Q-H---------------- --------------------------------LSIPRLELLAAV-LGA-RFSQSIKVG-- -H------S-IPI---GKT---ML---------WT------------------------- -------------------------------------WYLPLNVV-------LNPK-K-P SKI-RLVWDAAAA-V-HG---SSLNTALLKGPDLL--TNLPVVLYHFR---ERPI--AFG GDIMEMYHQIRIRRS--DKQSQR-----F------LYRND---T-SG---------P-PQ IYVMDVATFGSTSSPCSAQYA-KNKN------------A----REY-ANQF--P-DAVDA I-IHK--HYVDDY-LDSTD-D---VDQAVKRALEVR-LI-HSKA-------GFHIR-GWV SNSS-VF-LDKL--GE-----PRSEQLVHFSS-----------------------K-ATS T---E-----------------RV--LG-------------------------------- -----VAW---------------------------------------------------- ----------------------------------------------------------PR MRPFSFVGIDYFGPVI-------------------------------------------- ----------------------------VT--VG-R-----R-TE-----KR-WVA---L -MTCLT--TRAIHMEVAHSLTSQAC-----IMAIRRF-MCRR-GVPLEFFSDNGTNFQAV SKEFG-M-V------GRQ-IDI-E----------------------CA---DAFTDARTQ ----WNFNPPSAPHMGGSWERLVRSAKVVMKA-FE--D---G-GRL----TDEIL----- --LTV-----LAETEELINSRP--------LTY------------V-------------- ----------------------PQ-------------XS--------------------- ----------- >1185/1-571 ---QTKRQLASQIAKVFDPLGWLIPITVFARAIFRI-VCQA-S----------F------ -DWDD-P-LPS--SIAQEWSQFAVSLPDLS---K-IRIP--RFL---------------- ------SLPNPKC-YLVG-FADASER-AYA-AVVYLV--SQSE---------NTAI-S-- LVMS---------------------------KARM-APM--K-P---------------- --------------------------------VTLPRLELCAAH-LLA-LTIHKVSLLFP QI------T-------TQN---IL---------AF------------------------- -----------------------------------IAYYIPHHAV-------HRPD-DPP EKI-RVVFNASQKSS-SG---ISLNELLLPGPRLQ--LDIWKVVTRFR---VDKW--VFT ADIRQMFRQIQHPPE--DRDLLR-----I------LWRFD---T-SQ---------PV-Q EYRLCTVTYGTTSAPYLACRV-LQEL------------A----ITS-QKSF--P-LASEI L-RER--TYVDDV-SGGGC-T---PTEALQSRDQLI-KL-LGQA-------QIELR-KWA SNHP-QL-LDQIPPEHLLPAMSSVCLENDE------------------------------ -ESQL-----------------KI--LG-------------------------------- -----LCWNPSHDYFHFLIRSV-------------------------------------- ----------------------------------------------------------SA SSPFTTTGIDYAGPFN-------------------------------------------- ----------------------------VKIA--SLRS---AKV------LQSYLA---I -FVCFS--TKAIHLELVTDLTTQAF-----LAALNRF-VARR-GVPSHIWSDNGTNFVGA KRRLK-E-------VSALLNDA-KS------------------QEAIL---RESNKRSIE ----WHFIPPRAPHFGGLWEAAVKSTKRLLKVTLG--T-----QEP----TMECF----- --LTI-----ICQIEAILNSRP--------LTA------------V-------------- ----------------------SS--------SPD--D-------L-------------- ----------- >1186/1-541 ----TRRTVLAQLAKPFDPLGLAAPIILQAKLIRQQ-ADADKP----------G------ -TWDK-P-LSQ--DIEKKWRKLMNHWDG-I---E-IKVN--R-I--V------------- ---NPCWDRKVIY-QLHV-FTDASYL-AMG-ASIYLR--TITENK--------IES-R-- LIFG---------------------------KSLV-IPS--N---MPEAR---------- --------------------------------RTIPNLELHAAM-LSC-KYARFVKDQ-- -L------E-KEIKI-ENI---QI---------WT------------------------- ---------------------------------------SP-MGI--------------- -KL-RIVYNASAKKA-HS---LSLNQCLEKGPNLF--NDLAGILLRAR---MKKI--LLC GDIAKAFHMIELHPK--DRDVVR-----F------LWASN---P-ED----ENSQ--L-E EYRFTRVTFGVICSPAHLALT-IEMH------------L-------RKFQG--I-LV-KQ L-GDN--VYVDNL-LVGLE-S---DKEIIKTYKEMK-KI-FKEG-------GMEVR-EFI SNS--KE-IEKIPVEDR--I---------------------------------------- DKNVV-----------------KL--LG-------------------------------- -----TKW---------------------------------------------------- ----------------------------------------------------------NG SAAFQFVGIDYFGPFA-------------------------------------------- ----------------------------TNS--LEFK-------------KC-WGV---I -FTCTL--TRSIHLEVVSDCTSEKF-----LLAFIRF-IRRR-RVPHIVISDNAPTFVLA NKVMQ-K-------MCSEEKQQ-KNRWLDVMR-----------SDKVQ---DFLLLKQIQ ----WKFNTAYSPWRGAFYERLIGSIKHHLYRVIG--K-----KII----QFEEL----- --YTL-----LIEVERILNERP--------LTY------------Y-------------- ----------------------TS--------R-E--L---------------------- ----------- >119/1-540 ---PTKRQVLRVVMSHFDPLGLVATYTVHGKILIQD-VWRS-G----------V------ -KWDE-P-ITT--EDFEKWQRWVRLIPNLR---Q-VQIP--RCY--F------------- -PNYSLA-SYDTL-ELHV-FVDASLM-AYC-ATAYFR--IMD--NG------SPRC-A-- LVAA---------------------------KTKV-TPL--K-P---------------- --------------------------------QSIPRSELCAGV-IGV-RLLRNIQEN-- -H------S-IPV---QKR---YL---------WT------------------------- ---------------H---------------SDQRRVWYLPLGIV-------QNPR-K-P GKV-RIVWDAAAR-V-GD---VSLNSMLLVGPDLL--TPLLKVICGFR---QRQY--VAV GDVRQMFHQLLVKQT--DRQAQR-----F------LFRHD---P-EE---------Q-PT VYIMDVVIFGASCSPCLAQHV-KNTN------------A----KEY-AEAF--P-EAASA I-INC--TYVDDF-LDSRD-T---VDETVRIVEEVR-WI-FDKA-------GFEIR-NWQ SNSE-EV-LRRV--GVDV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY VRPFTFTGLDYFGPLI-------------------------------------------- ----------------------------VK--RR-R-----S-NE-----KR-WVA---L -FTCLT--IRAVHVEVVHTMSAESC-----KMAIRRF-ISRR-GAPQQIFSDNGTNFRGA AREIA-E-E------IRT-INR-K----------------------LA---GMFANTEIE ----WVFNPPSAPHMGGVWERKVRSIKDALKS-LH--H---K-QSL----NDEEL----- --MTF-----LAEAELIVNSHP--------LTF------------V-------------- ----------------------PL-------------EDSAEEAITPYNF---------- ----------- >1191/1-539 -----RRTVSSAIAGIYDPNGFLAPLILPAKLFQRE-LWID-T----------------- YGWDT-K-ISK--IHNESWLNIAEQIDGFT-----RDMP--RHV--I------------- -QKNKPN-------TLIT-FADASKD-ATA-TCIYVK-------NE-------IGV-H-- LIFA---------------------------KSKV-KPIKEK------------------ --------------------------------WTIPKLETQALK-MAT-EKTVQVWKA-- -LTQGDMTV-------DKV---YI---------MT------------------------- -------------------------------------HYNPIQAV-------ITP-QKTT TKC-RLVVDGSSHYK-NE---PSLNDIIEQGPVIL--PDIVDMLLRFR---SGKT--AIT SDVAKAFLQVFLHEE--DRDLTR-----I------LWVKD---F-RK----AVTEDNI-Q VFRFTRVLFGLNVSPYLLAAT-INHH------------L------SQLPDK--K-LS-KE V-INN--IYVDNV-IITTDGS---TEEAVQIYKKLK-TT-FTDM-------NMNLR-EFW SNSQ-EF-NSQLEEADK--A---------------------------------------- KDENF-----------------KV--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------KP TKPFDCTGLDNFGPIT-------------------------------------------- ----------------------------IKKE-DGTED------------SV-YGT---I -FTCAV--TRLVHVEVVSDMSTQQF-----IQAFRRF-VAIR-GMPKKIVSDNGTNFVLG KKIIE-E---------AM--T-------ND--------------PL---------CQSIE ----WKMITPYSPWKGGFYERMVKSVKHAFMKNQR--R-----NKL----SLEEI----- --QTV-----FYEVTATINSRP--------LTY------------L-------------- ----------------------EE--------DVN--N-------QSPIRPIDF------ ----------- >1192/1-534 ---PTKREVLRTLMMMFDPLGFISHFLMYLKVLMQE-IWRT-S----------I------ -EWDT-P-IED--PQFQKWLIWLKVLPKVI---N-VQIP--RCY--R------------- -TTVSLE-GS--I-QMHT-FVDASES-GFA-AVVYLR--FEE--GD------FVET-A-- FVSA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQASV-LGV-RLANSITQS-- -L------S-VKV---WKR---YF---------WT------------------------- -----------------------------------REWYLPVFPV-------CNPN-K-P GKL-RLVWDAAAT-V-QG---ISLNSVLLKGPDQL--TSLLTVLVQFR---EFRV--AVC GDIRDMFHQVLMKEE--DQHCLR-----F------FWKGD---T-QC---------SAPD VYAMTVMTFGACCSPTTAQYV-KNTN------------A----KRF-EHEC--P-QAVDA I-VKK--HYVDDM-LASVE-T---EEEAVKLAQDVK-RI-HAAG-------GFEMR-NWL SNSS-VV-RASL--K-----------------------------------------EE-A TT--E-----------------KY--LG-------------------------------- -----AGE---------------------------------------------------- ----------------------------------------------------------VY SRPFTHMGVDYFGPIL-------------------------------------------- ----------------------------VT--AN-R-----K-TE-----KR-WVL---L -ATCLT--IRAIHLQIAHTLSTDSC-----IMALRNV-IGRR-GTPAVIYSDQGTNFRGA SKELK-T-------AMDDLDKE-R----------------------LK---GEFTTRHTT ----WSFNPPASPHMGGAWERLIRTVKQNLNKLLL------N-RTM----SYEVL----- --ENL-----LIEVENVVNSRP--------LTS------------I-------------- ----------------------PL-------------ED--------------------- ----------- >1193/1-555 ----TRRELLSQVASLYDPIGLATPTKQKGVILVRK-AFQEVG----------GGAK-TK DTWDN-P-LSD--HLREEAMQLFEDYIRLS---H-ITFP--RSL--T------------- -PVDWVGNPCGIT------FSDGSDK-SYG-AVVYFR--WETI-KG-------VQV-R-- LVES---------------------------KAKL-TPLNQK------------------ --------------------------------GDAVKAEMCGAV-FAS-RLRLYVEKH-- --------SRMKI---DRW---YH---------LV------------------------- ------------------------------------IWYVSHLIA-------PKPN-SMS TPV-RLVWNSSQK-F-NG---LSMNDLLLKGPDVL--NPIRAVLIRFR---RGVH--AAL GDIKKMYNSVWLEEK--EMHLHR-----F------LWRDD---E-EQ---------KISE -YAITRVNMGDRPAGCIAQLA-MRET------------A----NLQ-MFIN--LGEERWI V-EED--SYVDDI-LTSSN-N---LESLNENIKGVE-RI-LKAG-------GFFLK-PWI RSGQ-SG-RHTETSDPLAPTNENKVLILPN------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------RP AQPFEFTTVDLFGPYE-------------------------------------------- ----------------------------VKDEVRKRVRL-----------KV-WGI---V -FSCMA--SRAVHADVVSDQSTGGF-----LLAYKRF-TAIR-GHPRKLWSDPGSNFVGA KPALE-S-------LYLFLDRL--------------------EKSDIQ---NEAALHGTE --WSWKIHPADSPHRNGAAEAAVRVLKRALHNLGG--D-----GIF----TWGEF----- --QTF-----LYMAANLTNERP--------IDA------------R-------------- ----------------------TQTQEDC------------------------------- ----------- >1194/1-509 --------------------------------------WVK-G----------I------ -EWDD-Q-IPT--DLCQRWGEWIKLLPHLE---K-LRIP--RCY--F------------- -RSPYPE-NLHDL-QLHV-FVDASET-AYC-SVAYFR--IDI--DG------TIHV-G-- LIGG---------------------------KTKV-API--K-T---------------- --------------------------------ISIPRLELKAAV-LGV-RMXNVIRDN-- -H------S-FPI---KRH---IL---------WT------------------------- -------------------------------------WYLPLGIV-------QNPK-K-P GKI-RLIWDAAAK-V-SG---VSFNSKMLKGPDLL--TPLPQVLSQFR---QFPV--AVS GDIMEMFHQIKIRHP--DRQSQR-----F------VYRNR---P-SD---------H-MQ VYVMDVATFGSTCSPASAQYV-KNLN------------A----QEY-IEKF--P-RAAKA I-IDN--HYVDDY-LQSFT-T---VAEAIEVMKEVK-HV-HSKG-------GFTLR-RFL SNSA-EV-LNSI--GDP----AEET-SKDLML-----------------------E-RGE NT--G-----------------SV--LG-------------------------------- -----MKW---------------------------------------------------- ----------------------------------------------------------AF TKPFTYTGVDYLGPVL-------------------------------------------- ----------------------------VR--VG-R-----A-NA-----KR-XIA---L -FTCLT--VRAVHLEVVYSLSTESC-----IMAVKRF-IAKR-GTPIEFWSDNATCFQGT SNEIK-E----------E-ISS-A----------------------LA---VTFISQITN ----WKFIPPATPHMGGAWERLVRSVKTAISTVID--S---P-RKP----DDETL----- --ETI-----LLEAEAMINARP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >1198/1-528 ----TMRNIYKVLARQYDPLGFIAPYTTRAKLIVQS-MWDK-P----------R------ -DWDD-PCIPP--DLQKAWTTWESELHWLP---H-IAVP--RPY--A------------- -PGLTEP-MVVSR-QIHV-FSDASTK-AYG-SVAYIR--TEDV-QG------RIQV-A-- FLAA---------------------------RSRV-APR--R-Q---------------- --------------------------------HSIPRLELCGAL-TAA-QLAKKIETE-- -L------T-IKT---DKP---IL---------WS------------------------- ---------------V---------------LDSAESYYIPHHVV-------RHN----- GKS-RIVFNCSFP-Y-QG---RSLNDTLLPGPTLG--ASLLGVLLRFR---EHAV--AIS SDIRGMFHQVQLLPE--DQPLLR-----F------IW-RD---MKRA---------DPPA VFQWQVLPFGTACSPCCATFA-LHRH------------A----RDH-SGV---NNAVLHS V-EHC--FYVDNC-LQSLP-T---AEEAKELVDQLR-DV-LASG-------GFELR-QWA SNVP-DV-LRHL-------PAEV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LY QPAFYSTGVDCFGPFQ-------------------------------------------- ----------------------------VR--IG-R-----R-SE-----KR-WGI---I -YKCLT--TRAVHLDLLHAMDSDSF-----LMSLRRF-IARR-GSPAELYSDQGTNFRGG EKELS-E-------WFSRMSPD------------------------LQ---QLLAKQKIA ----FCFNPPAAPHFGGTWEREIKSVKMALNTVIG--A---Q--PI----SEEVL----- --RTV-----LLEVEAILNSKP--------LGY------------T-------------- ----------------------SS-------------NV--------------------- ----------- >1199/1-559 ---PTKKEVVSVLMSIFDPLGLLANVLMFLKVLIQE-IWRS-K----------V------ -GWED-P-ITA--TQFEKWLTWLKVIEQVE---N-VTVP--RCY--R------------- -QITSSS-SKTNV-QLHM-FVDAGVQ-GCA-TVGYLR--FEE--AD------RIEC-A-- FVAG---------------------------KTKV-APN--K-L---------------- --------------------------------TSIPRLEIDAGT-MGV-RLAQKIMEA-- -L------R-IVI---HQR---FF---------WT------------------------- -----------------------------------RVWYLPIFVV-------TNPN-K-P GKL-RIVWDAAAT-V-RG---ASLNSFLLKGPDQL--APMVNVLYRFR---EYRT--AVT GDIREMFHQVGVHPE--DQHCQR-----F------LWNNG---R-PG---------STPS IYVMQVMTFGATCSPSCAQFV-KNTN------------A----ERF-NEDH--P-AAVNA I-IND--HYVDDM-LSSVE-T---EQEAIELATSVR-DI-HAQG-------GFEIR-GWR SNSS-SV-LEAL--SA---EQLN---EKNLNV-----------------------IAQ-F ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------GF SRPFSYTGVDYFGPMC-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -LTCLV--TRAVHIEIAHSLNTDSC-----IMAIRNF-AALR-GTPLELFSDQGTNFIGS DRELR-E-------ALQKIDND-K----------------------LF---KEFTTPNTK ----WTFNPPSSPHMGGSWERMVQSVKKILTQLKL------P-RNP----TDEVL----- --RNT-----LLEIANVINSRP--------LTY------------I-------------- ----------------------PI-------------DDENSPALTPNHF---------- ----------- >12/1-521 ---FTKRQVLSQIAKLFDPAGWLAPFIVRAKIFMQE-IWLQ-E----------L------ -GWDE-N-IPN--ELFQRWLNFLQSYSVLE---Q-IRIP--RWL--S------------- -FHPDF-----KV-EHHG-FCDASQK-AYG-AAIYVR--VEVG-ST------I-MV-Q-- LLTA---------------------------KTRV-APV-------K------------- ---T----------------------------VSLPRLELCGAL-LLS-EMAAAIIPQ-- -M------P-TIN---SEL---YC---------WT------------------------- ------------------------------N-----AYYMPHHAV-------LKPE-SVT TKL-RVVFNASSPSS-NG---TSLNDILHAGPVLQ--SDLTIQILKWR---YFRY--VFN ADIEKMYRQIWVDPK--HTPFQR-----I------LFR-N---N-RG---------EI-R DFELKTVTFGVNCAPFLAIRV-LQQL------------A----ADV-ELSH--P-KASNV I-RNF--MYVDDV-LAGAD-S---TEEAQLMVQELR-DA-LNSA-------GFPLR-KWT SNQK-EV-LAAIQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SF SRPFTYTGMDYAGPFD-------------------------------------------- ----------------------------IKNY--TGRA---CLIT-----KG-YVL---V -FVCFS--TKAIHLEPTSDLTTEKF-----LAAFSRF-VSRR-GCPRQVQSDNGKTFVGA ATLLSRD-------FLQAV------------------------KESVT---NAYIHQEMQ ----WQFIPPGAPHMGGLWEAGVKSFKTLFYKCTA--T-----RKY----TFEEL----- --STL-----LAKIEACLNSRP--------LSP------------M-------------- ----------------------SE------------------------------------ ----------- >120/1-518 -----KRLLLKYISKLFDPLGFLSPFVIRAKILFQE-LWTS-G----------E------ -DWDE-T-LPD--KIKQKSDIWFNELTSIH---Q-CKIP--RCL--R------------- -IKNNDK--IIYS-ILHV-FVDASQT-AFG-TVCYLV--HGYE-FG------GMSS-S-- FVSS---------------------------KTRV-APL--N-L---------------- --------------------------------VSIPRLELMSAV-LGL-KLALSVVEA-- -L------P-CTIKM-ENV---IF---------WS------------------------- -----------------------------------ILW---HFSV-------VKLE-KET AKV-RIVFNAAAK-C-QG---VSLNDXIHQEPKLQ--RDLCFILLRFX---RNAV--ALL GDITEMYLQIELNPK--XRRYHR-----F------LWXDL---E-EN---------KNPE LFEFTRVVFGVNSSXFQAQFV-IQKH------------X----EKY-KKKF--P-LAAET V-DKS--TYMDDS-XDSVE-T---EEKAIELYNQLT-QL-WKKX-------EMTAR-KWI SNSK-TV-MEC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------FS MKAFERCAVDYGGPFI-------------------------------------------- ----------------------------TIQGRG-K-----K-RA-----KR-YLA---L -FTCLS--SRAVHLEVAFALDAESF-----LNAFFRM-SSRR-GTPKEMISDNGGNFVLA NKELR-S-------F-TDGEKK-R----------------------IN---EATSHVGIK ----WHFNPPAAPHFGGVHEIMIKAAKRAIYSQLG--N-----VDI----TDEEL----- --ITA-----FAGAEGLINSRP--------LTL--------------------------- ----------------------YQ--------S--------------------------- ----------- >1202/1-542 ----TKRKLLSQSSKVFDPMGLCSPILIEAKRFRQE-IDKNRK----------V------ -GWDK-L-LSN--KEREKWFSIIKEWNN-Q---S-IAIK--RPL--H------------- ---NFIKKNIEKY-EIHA-FSDASQI-AFG-AAIYIR--IITKNE--------IIV-K-- IIFG---------------------------KSLI-IPS--T---LPIKR---------- --------------------------------RTIPNLELHATM-LCA-KYSEFVKKE-- -L------E-KEIKI-DKI---QI---------WT------------------------- ---------------------------------------DK-----------------EH TKI-REVFNGAAKTG-NA---PSLNECLEKGPNLF--NDLTGIQMRAR---LQKY--LIG CDIAKAFLQINLDPV--DRDVTR-----F------LWMAE---P-LE----EDSP--V-I EFRFKRVTFGIICSPAHLALA-IEMH------------L-------KKDKT--E-LA-RE I-ERN--IYVDNI-IIGVE-E---EKEIPDICQQTK-LI-FEKA-------SMPIR-EFI SNS--EQ-INKLPVEER--I---------------------------------------- VKDKV-----------------KF--LG-------------------------------- -----LEW---------------------------------------------------- ----------------------------------------------------------KG ESAFMNVGLDYFGPIV-------------------------------------------- ----------------------------IKS--KDCN-------------KV-WGA---I -FTCLL--SRGIHIEIVTDCTSEKF-----LLAFRRF-IRRR-RTPRLIVSDNGKTFVLA NKVIK-Q-------IGSEELEQ-KKIWLKIFN-----------DKQIQ---KFARNKEIE ----WKFNTPLSPWRGGSFERLIQSIKFHLKRVVR--K-----NTC----TLEEL----- --MTL-----LVEIERIINERP--------LTY------------I-------------- ----------------------SS--------A-E--I---------------------- ----------- >1207/1-522 ---PTLRNIYKVLATQYDPLGLLLPYTTRAKIIIRE-IWNK-Q----------R------ -GWDD-PNLPS--ELLQSWYSWEEGLQYLP---N-ITLP--RTY--T------------- -PTGMEM-DGVTH-EVHI-FADASEQ-AYG-AVAYKR--TTDN-RG------QVHL-S-- FIVA---------------------------RSRV-APK--R-S---------------- --------------------------------HSIPRLELCGAL-VAA-QLAKLLEKE-- -L------T-LKI---EST---VL---------WS------------------------- ----------------------------------SECWYIPHHIV-------SHN----- GKS-RVVFNCSHQ-Y-QG---QSLNQYLLPGPTLG--ASLLSVPLRFR---EHPV--AVS GDIRAMFHQVRLLPE--DRPLLR-----F------LW-QD---LKMD---------EPPK VFEWQVLPFGTTCSPCCANYA-LQRH------------V----IEH-SVD---NASLRFS V-EKC--FYVDNC-LQSVG-S---SEEARCLVDGLR-EM-LSRA-------GFDIR-QWA SNVP-SV-LSHL-------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LH KPAFYSCGVDCFGPML-------------------------------------------- ----------------------------IK--IG-R-----X-TE-----KR-WGI---I -FKCLT--TRAVHLDLLSSMNTDSF-----LMAMRRF-IARR-GTPAELWSDQGTNFKRG ERELK-E-------AFMEITPE------------------------LQ---KQLACQKIQ ----FHFNPPAAPHFGGVWEREVRSVKSALYTTVG--T---Q--SV----PEEVL----- --LTV-----LLEVEAILNSKP--------LGY------------V-------------- ----------------------SS-------------DI--------------------- ----------- >121/1-535 -----KRSILSEISKLFDPLGWLSPVLVRAKLMLQD-LWIN-G----------V------ -DWDS-P-LTG--ELLEQWQALRSDLPELA---Q-LRIP--RWF--G------------- -SSSQT-----SW-ELHG-FSDASQR-AFV-AAAYMV--IPGQ-KS------A------- LIMS---------------------------KTKV-API-------K------------- ---T----------------------------ESLPRLELCGSV-LLV-RLLKHLLDG-- -L------L-LKP---VSV---HC---------WT------------------------- ---------------------------------------FTHHPV-------YSAEVGPE GKF-RVVFNGSF----GK---ISLNDVLLTGRKLQ--SDVTIIISMWR---FSKI--VFT ADIIKEFRQILIHPD--DVDWQR-----I------VWRSD---V-SK---------PI-E DYRLLTVTYGTRSAPYLSIRT-LLQL------------A----SEG-SVEF--P-LAAQV L-RHN--MYVDDA-FVGAD-N---ESEAIEIRNQLI-KL-LSSA-------GMELG-KWA SNCS-AI-LEDIXAEKQKEFAVEW------------------------------------ -DEAX-----------------SA--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TP QRVFAYTGLDYAGPFP-------------------------------------------- ----------------------------ILFS--KGRG---AKST-----KG-YIA---I -FVCMV--VRAIHIEVVSDLSTAAF-----LAAFRRF-TARR-GLCKMVFSDNGTNFKGA ATEID-K-------LFQRASSV-SQ--------------------EVA---AALAKDGIV ----WSFIPPRAPHFGGLWESAVRSFKHHFKRVIG--D-----TSL----TFEEM----- --STV-----AAQIEACLNSRP--------LCP------------L-------------- ----------------------SS------------------------------------ ----------- >1211/1-543 ---PTRKEVTSFQAQNYDPSGMIIPILIKLKKFISL-LC-ERK----------L------ -KWKD-K-IPN--DLIPSWLELKKQFTGTT-----FTIP--RQL---------------- ---V-TAYDYKTV-QLIT-FSDASKD-HYA-TAMYMR--YGY-EDG------TFQS-R-- LIFA---------------------------KSKI-RPSNSGPE---------------- --------------------------------FTIPRMELMSME-IAT-NAAVNITKE-- -L------H---IKL-DNV---VF---------WS------------------------- -----------------------------------PEYHVPHRGV-------VKN-ESLT TNL-RIVFDASSHMR-NE---LSLNDTLYPGPSIL--QPILGILLRSR---LTKY--MMV ADLEKAFHQVHVQEK--FRNVTK-----F------LWLRN---P-DK----GYTEDNL-V TYRFTRLPFGVTCSPFLLAIT-ILRY------------M-------ELDVQ--E-IN-PR I-IEN--LYVDNT-MFTSN-S---KEDMEQCYKQSK-AV-FKKM-------HMNLR-EFL CNVP-DV-MDIIDEKDR--S---------------------------------------- PQQSC-----------------KL--LG-------------------------------- -----HKW---------------------------------------------------- ----------------------------------------------------------TM IAPFKFIGLDYIGPLQ-------------------------------------------- ----------------------------YK-RSS-GCG------------KM-WIL---L -VTCLV--TRGVHLEVVTDHTTLGF-----LNAVKRV-FARR-GVPSHILSDNAPEFKLG YAMIN-Q-------DLRT----------LVNR-----------DDNLT---SFIAQNEIT ----IKLITPLSPWQGGIYERLVALVKNILTKELG--K-----EIR----PFLEM----- --ETL-----VIEAEAIINSRP--------ITP------------N-------------- ----------------------K--------------------------R---------- ----------- >1214/1-553 ----TKRTLLSAVAKIFDPLGLVGPVVCKAKLLMQQ-AWTS-I----------DPITGKP IDWDV-N-LPT--KLQHAWKAFQQTIHIVE---N-LNIP--RYV--F------------- -GNAGL-----DKCEFHI-FGDASEK-AYG-SCCYIR--APSE-SG-------VSI-H-- LLVA---------------------------KSKL-APV-------K------------- ---TH---------------------------HSIAKLELCAAL-LSV-QLYDKISTA-- -L-R----F-N-P---TKI---IF---------WS------------------------- -------------------------------------CYLPHHPV-------LKES-SST TKV-RVVFDASCKTT-SG---YSLNDALQVGPTVQ--VDLFSLIVHFR---THRI--AIS ADVEKMYRQVMVHVD--DQPLQR-----I------VWRPS---A-AE---------EL-R SYQLKTVTYGTASAPFLATRA-LKQI------------A----LNA-ADKY--P-IEAHA I-TNN--FYVDDF-LSGAN-D---EESAATLQKNVS-NL-LQQY-------GFVLR-KWA SNSK-RV-LDDIADEDLATPR--C-H-NLG---------------------------T-- -DP--------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------VP APPFSISGVDYCGPFY-------------------------------------------- ----------------------------VKFG--TRKT---IPR------KV-YLS---I -FVCFA--TRAVHIEVVSDLTTQAF-----IAALQRF-ISRR-GRVKELHSDNGTAFKGA ANLLH-Q-------LYVQLKTD-PKS-----------------REIIF---NWCAVNEIT ----WKFIPPRAPHFGGLWEAAVKSAKQHLLKELG--S-----STL----LYDDF----- --LTL-----CARVEMCLNSRP--------LTP------------I-------------- ----------------------PN--------SPD--D-------L-------------- ----------- >1217/1-558 ---MTKRKLVGEITTIFDPLQIFAPLYYDGKIILRD-VSDH-Q----------I------ -KWND-V-VEK--DLAIKTLNYKQKIATST-----LKFR--RNT---------------- -----ESNGNIPI-QIAI-FTDAAEA-IYG-TCLYLKIPIQER-PG------QFEI-H-- LLIA---------------------------KQRI-APKIKT------------------ --------------------------------LTIPRLELMGIL-IGV-RLLKYTLSE-- -M------N-LNP---SKI---EI---------FS------------------------- -------------------------------------------------------S-SNT TKF-RVVFDASSKVRGG----ISLNNALHQGPSLT--PNLIGILLRTR---QGHY--ILI GDIEKAFHMVEVNEQ--DRDALR-----L------LWFEN---P-DE----GFRNMENVI IMRFKRLPFGVNCSPFLLSMALVHGI------------Q--------QSDA--PKELVEA V-EQM--CYVDNF-FITTD-D---INKLPEYYTSLK-HY-FNQM-------GMNMR-EFS VNSC-DD-F-------IRPEDKVKNT---DNI---------------------------- ----------------------KV--LG-------------------------------- -----YLY---------------------------------------------------- ----------------------------------------------------------TP CRPFQHIGVDFLGPIK-------------------------------------------- ----------------------------TQVRNSSEIL------------KS-HIL---L -ITCAT--TRLIHLELVRDLSTDEF-----LMALSRF-MNRR-GCPETITSDNASTFTLA SEILD-R-------YAHEEDEF-FANLDFEQIDNFREKDAKSKTNILE---KEMSKKRIK ----WYFNTALAPWQGGFYERLVGIVKKALKHALG--D-----SLY----KTTNL----- --ETL-----ITECESMINRRP--------ITY------------I-------------- ----------------------DE--------DSE-----------------DC------ ----------- >1218/1-564 ---PTRRGLLSVIASLYDPLGFVAPFTLSGKHILQE-LCCR-G----------I------ -GWDD-P-IPE--NLRSRWEEWKNGLQRLK---E-IAIP--RCY--Y------------- -PQNFGE--IVRV-ELHH-FADASNA-GYG-SCSYLR--YQNN-RN------EIHC-S-- FVMA---------------------------KARV-APT--K-I---------------- --------------------------------TSIPRLELSAAV-TAA-RMSVMLKAE-- -L------E-MKI---EQE---FF---------CT------------------------- -------------------------------------WYIPHHGV-------YNPK-K-P DKL-RIVFDCSAK-F-RG---ISLNDTLLTGPDLI--NPLLGVLCRFR---REAV--AVI CDIERMFHQFSVSPE--VRNYLR-----F------LWWEG---GLFE---------REPQ EYRITVHLFGAASSPGCANVC-LKYL------------A----QQH-KVNY--PAAS-AF L-ENN--FYVDDG-LTSVP-T---VKEAKKLIVETQ-EL-CKGA-------GLRLH-KFN SNQS-EV-LSCV-------ASSERAVNTDPLN-----------------------LKPYP -AAGA-----------------HI--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------EV SAPFTFCGMDCFGPFV-------------------------------------------- ----------------------------TK--RG-R-----K-EY-----KR-YGL---I -FTCLS--SRAIHLEMLDDLSTDVF-----INALRCF-ISLR-GAVSHLRCDQGTNFVGA KNEFK-E-------APKQCDTE-A----------------------LK---AFLADKQCE ----FTFNAPSASHAGGVWERQIRTIRSVLNVTVA--Q---CSGRL----DDASL----- --RTL-----FYEAMAIVNSRP--------LNV------------D-------------- ----------------------GI--------N----DPMAPEPLTPNHL---------- ----------- >1220/1-552 ---NTKRQLLSDSCKLFDPFGWLAPVTIKVKTLFQQ-LWLS-E----------L------ -SWDD-S-LPP--AVESAWIEIKETLQQVE---Q-IRIS--R-F--V------------- -PNYNGK--I----ELHG-FSDASET-AYA-AVVYAR--GTNE-AG------EIIV-N-- LLTA---------------------------KTRV-API--R-Q---------------- --------------------------------VSLPRLELNAAA-LLS-TLMESIMQA-- -L------N-HLE---VEP---WA---------YT------------------------- -------------------------------------FYLPHHAV-------VKAD-STT TKL-RVVFDASCASS-TG---VSLNDRLLAGPNVN--QDLYSVFLRFR---TYQV--AFS ADVEKMYRQVVVHPA--DRDYQR-----I------IFRHK---E-DQ---------PI-K HYRLCTVTYGTKCAPYLAIAA-MKRA------------A----EEY-QHVY--P-EATLR I-VLD--TYVDDF-LSGAQ-N---VQQARQLKEQVM-EI-LQSA-------GFHLR-KWT TNCP-EL-LQEEIQDDQEPVDVQL-AEQAN------------------------------ ---AV-----------------KA--LG-------------------------------- -----IQWLPTED----------------------------------------------- ----------------------------------------------------------MG TRAFTHVGVDYAGPLK-------------------------------------------- ----------------------------VHAS--CVRG---VKTT-----KG-YIV---V -FVCMA--TKAVHLEVASDLSTSTF-----ICALKRF-ISRR-SHPNEIWSDCGTNFVGT DHWLK-E-------LQSARQIH-NE--------------------ETS---RFLSNLGIK ----WVFNPPSAPHRGGIWEAAVKSAKKHLVAVLG--S-----EAA----TYEDL----- --STI-----LTQVEACLNSRP--------LCP------------L-------------- ----------------------ST------------------------------------ ----------- >1223/1-540 ---PTKRDVASKMAETFDPLGQVSPIQVPMKRLIKK-LW-SND----------V------ -NWKD-L-IPE--HLIGDWRAIQAAFNSPT-----VTVP--RRL---------------- ---T-TDFNYKEI-QLLV-FSDASQD-IYA-AAVYAH--FSY-EGL------PPVT-T-- LLTS---------------------------KNKI-KPSKDD-K---------------- --------------------------------WTIPKLELLGIE-IGS-NLASTIMSE-- -L------R---CKV-SKI---RL---------FT------------------------- ------------------------------------SFMLPHRPV-------IKE-SSNT TKV-RVVYDASSHAA-GQ---LSLNDVVHAGANMV--TPLFGILLRSR---FIRF--MIV GDLEKAFHQIHVQPE--FRNLTQ-----F------LWLKD---I-DK----PVTMDNI-C VKRFVRLPFGMSCSPNLLGSA-IVHF------------L-------AQNPD--E-LN-AD I-LDN--LYVDNI-LIGVD-D---PALIMNRITRLK-EI-FNKM-------KMNIR-E-- --------LEAIDPKDR--A---------------------------------------- PDTKI-----------------KF--LG-------------------------------- -----YKW---------------------------------------------------- ----------------------------------------------------------EP SSPFQRVGLDYLGPLE-------------------------------------------- ----------------------------YLKDDGVSLG------------KA-YVL---V -YSCFV--TRAVVLRVVPDGSTEKF-----IMALKTI-FHQV-GVPQMVYSDNAPTFILG GTVLN-T-------DISS----------WEDR-----------NESLT---SFMVARSIH ----FFRITTLSPWQGGMYERIVGLVKHQMHKVCE--A-----NKF----DYYTL----- --SYV-----VSGAQAMVNNRP--------LTQ------------H-------------- ----------------------AR--------SPD--D-------M-------------- ----------- >123/1-538 ----TKRNALSDVAKLFDPIGLVGPVIIQAKLFLQE-LWRC-Q----------I------ -AWDE-P-LTP--ALQNRWLLFREKLAMLQ---T-IHIP--RWL--L------------- --TDQR-AT--NL-QMHC-FCDASEK-AYG-AAIYLR--STNT-DG------RVTT-N-- LITA---------------------------KSKV-APL--A-DSRK------------- ---QKR--------------------------VCLPRLELSAAL-LLA-HSYEKVSDA-- -L-K----L---Q---VET---IF---------WS------------------------- -----------------------------------PSYYLPHHCI-------VRPD-STT TKL-RVVFDASCASD-TG---TSLNDALMIGPTIQ--DDLMSILLRFR---MSKF--ALV ADIEKMYRQINIAAI--DRPLQR-----I------LWRNS---P-TE---------PI-R TFQLNTVTYGTSCAPYLATKT-LQVL------------S----QVG-ASTH--P-EAATI L-GRD--FYMDDM-LTGVN-S---IPEGQRVCQQLI-DL-LASG-------GFCLR-KWA TNNR-QI-FEHLPQHL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP TSTFLHTGVDLCGPIH-------------------------------------------- ----------------------------YRHT--SRKA---QLI------KG-YVA---I -FVCMA--VKAVHIELVADLSTNAF-----LAALRRF-IGRR-GKPAIIECDNARNFLGA SREIA-S-------LSKQF-NH-QW------------------QTSVI---KSCIDDGIQ ----FKFIPPRSPNFGGLWEAAVKSFKTHFKPTVG--N-----AIL----TSDEL----- --NTL-----LIQIEGCLNSRP--------LTP------------L-------------- ----------------------SN--------DPS--D-------L-------------- ----------- >1232/1-547 ----TKRKILKIIASCYDPLGFLTPVTLYGKLFFQQ-LAT-KD----------Q------ -SWDL-P-LSL--NQHDSWKNVCTKWTG-S---E-WRLK--RKL--F------------- --PDNFNIKTDQL-ELHI-FTDASQL-AYG-SVAYLR--ITQSNGK-------ADS-N-- YLLS---------------------------KSRV-APV--K------SK---------- --------------------------------YSIPQLETLGIL-TGV-RLGNYCFQH-- -I------G-LKIH---QA---YV---------WS------------------------- ---------------------------------------LPHHPV-------IKE-TSKS TKV-RIVFDGSAKTN-KV--SHSLNDHLHTGERLL--PDIAAIMLRIR---QHNI--LIS GDIEKAFLQLVLHQT--DRDVTR-----F------LWK-------------DPTDGHL-I CYRYRRVPFGLKPSPYLLNKT-VRTH------------L-------ESYDH--T-WA-QA M-INS--FYVDNV-FMGLD-T---AEEDMDFYVFAK-KV-FAEA-------QMNLC-QFC SNSS-TV-NTFFVKHE-KDTT--------------------------------------- IDRNQ-----------------KI--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------TH SNPFQFTGTDYAGPLL-------------------------------------------- ----------------------------VKIN-NSP--------------QKVWII---I -FTCLY--SRYTMAEVVTDMSTSSY-----LNALRRL-SALF-GTPKQLLSDNASQFKLL EDVFK---------LIKNKISSNV---------------------------NIMDSTTFP ---TIHYITPHAPWEGSVYERMVSLIKRALLRAGS------STTLF----ELDDF----- --RTL-----LAECVSTINMRP--------LTY------------Q-------------- ----------------------TT-------------DENIEPLTPTDF----------- ----------- >1237/1-556 ----TKRNMLSTVCSPYDPLGLLNPLILPPRLTTQS-LWNS-P----------L------ -KWDD-P-VDE--SVRVTFHEQMSEVENFS-----LSID--RFA---------------- -----HLSDSEEI-TLVC-FSDASKH-AMA-TCIYNW--SSNA-NS-----------T-- LLIS---------------------------KTRL-API--KSN---------------- --------------------------------STIPKMELDSLV-MAH-SLARFTVDA-- -LRKEFPKKPIHV---------YF---------FS------------------------- -----------------------------------------HQPV-------LRPD-KPS TPL-RIVFDASAHLR-NK---PSLNDMIHPGPSDL--ERIPAILLRAR---SRIG--LIV ADVEKAFLQVKLHQS--QRNMLR-----F------LWVKDLEKPASN---------SNII VYRFCVTPFGVNASPSLLNKV-IHYH------------I----RMNGSECD--P-ILVQQ L-LSN--LYVDNV-IINVDLP------LTRMYTQSK-SL-FDSM-------FMNLR-DFA SNDP-SF-LSVVDEADRAKGETQ------------------------------------- ----------------------KL--LG-------------------------------- -----LLWDTSTDKLSINIPVSNKKEKVTKRNMLSTVC---------------------- ----------------------------------------------------------RK SLPFEHCGIDYAGPFH-------------------------------------------- ----------------------------SKVDT-----------------KM-YVV---I -FTCFS--TRLSHLEVVDSLLPSTF-----MFAFRRF-CPRR-GTPAHVTSDKATTFKLA STLFS-K-------SEEDED-----------------------VNTL------LSNIGIQ ----WSFTTAHSPWKGGIYERLVKILKDSLARSIG--R-----RKL----SIEEF----- --TTV-----TCEVESLLNSRP--------LTY------------V-------------- ----------------------S------------------------------------- ----------- >124/1-569 ---YTKRSIIRTIAKIYDPLGIVDTVKAKAKQFMQR-VWSL-K----------K-ENGDS YGWDE-E-IPQ--QMRQEWEVFERQLTHLQ---E-VQVP--RCV--T------------- -IVGAR-----NI-QIHG-FCDASEE-GYG-ACVYVR--STNG-EE-------IVS-R-- LFVS---------------------------KSKV-TPL--A-T--K------------- --------------------------------HTIARLELCAAH-LLG-KLLVKLKRA-- -TED--------P---YET---FC---------WT------------------------- -------------------------------------YYMPHHAV-------FKQD-STT TKC-RVVFDGSCKTS-NG---RSLNDILKVGPTIQ--QDTTDILLRWR---RRAI--AVV GDVEKMYRQVWVHEE--DRKFQR-----I------LWRSH---S-SE---------KI-K TYELNTITYGTASAPFLAIRT-LNQV------------L----EDN-KEKY--P-LAAS- R-IND--FYVDDF-ISGAD-S---ENEAKQLCEETK-AA-LAMG-------GFPLR-KWA SNCP-HI-LPSET-EIDNIQRVIE-LKSRE------------------------------ -G-AV-----------------ST--LG-------------------------------- -----LVWNPILDTLGV-------------KI---------------------------- ----------------------------------------------------------RQ ARPFSISGVDYAGPIM-------------------------------------------- ----------------------------VKGT--HRRA---VPT------KG-YIS---I -FVCFV--TKAVHIELVSNLTSSAF-----LAALRRF-VARR-GHVTELHSDNGTNFRGA NNKLR-E-------LYKLLNSD-TH------------------QDEVV---GWCAERDMK ----WKFTPPAAPHFGGLWEAAVKSMKFHLKRVLG--T-----GHL----TFEDL----- --STL-----LAEIEACLNSRP--------ITA------------I-------------- ----------------------SE--------DPN--D-------M-------------- ----------- >1241/1-560 ----TKRTVCRHIAKIYDPLGLLDPVKMIAKIFMQR-LWTW-K----------T-EGDRA LDWDE-E-LPL--QLKREWHSYVEQLSKVV---N-VSVP--RLV--C------------- -PSDCT-----IM-QIHI-FCDASEK-GYG-ACSYIR--AETM-NG------KVSS-I-- LLIS---------------------------KSKV-API--A-N--R------------- --------------------------------QTLARLELCAAV-LGS-RLYGFIKES-- -LKA--------E---LRC---YL---------WT------------------------- -----------------------------------QEYYMPHHAV-------WKEE-STT TKC-RVVFDASCKTS-SG---RSLNELLLVGPQLQ--EDILSIYIRFR---FKPV--VLV ADVEKMYRQVWVEET--DRALQR-----I------LWRTD---P-NQ---------PI-G VFQLNTITYGTASAPYLAVKT-LQRT------------F----EDH-GKSF--P-KACE- C-MKD--FYVDDL-LTGAS-T---EDEAKEKKRQLE-AV-LAKG-------GFKLR-KWA SNRP-TV-LEGVA-KEDLALTEEH-LFESE------------------------------ -SKPI-----------------GT--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------SA SKPFSITGVDYCGPIF-------------------------------------------- ----------------------------TR-M--NRRA---VAR------KS-YIA---I -FICFS--TRAIHIELVSDLTTEAF-----IGALRRF-IARR-GKVVEIHSDNGTNFKGA ANQLN-E-------LYELLKTE-NH------------------ASSVH---HWCLERQIA ----WKFIPPRAPNFGGLWEAAVKSTKFHFVRVAG--E-----TSL----TFEEA----- --CTL-----LAEIEAILNSRP--------ITD------------I-------------- ----------------------ST--------DPE--S-------L-------------- ----------- >1243/1-523 ----TRRQLLSQVASLYDPIGLATPAKQKGAILVRK-AFQETG----------GKNL-LR DTWDT-P-LSE--RLREEAIHLFEEYTRLN---Q-ITFH--RSL--T------------- -PVRRIGEPWGIT------FSDGSDQ-SYG-AVAYFR--WETK-QG-------ILV-R-- LIES---------------------------KAKL-TPLDQK------------------ --------------------------------GEAVKAEVCGAV-FAA-RLRKYIEKH-- --------SRIQV---KRW---LH---------LL------------------------- -------------------------------------------------------N-SVT TPV-RLVWNSSQK-F-RG---ISMNDLLLKGPDVL--NPIRAVLLRFR---RGVH--AAL GDIKKMYNSVWLENL--EMHLHR-----F------LWRNS---E-DE---------EIEE -FAITRVNMGDRPAGCIAQLA-MRET------------A----RLP-MFTH--LEEERRV L--ED--SYVDDI-LTSHN-D---LEKLDRITKKVE-EI-LKAG-------GFFLK-PWV RSGQ-SG-RQT------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP ANPFEYTTVDLFGPYE-------------------------------------------- ----------------------------VKDEVRKKVKL-----------KV-WGI---V -FCCMA--SRAMHTDLVSDQSAEGF-----LLAYQRF-TALR-GHPRKLWSDPGKNFVGA KPALK-E-------LHMFLDRL--------------------EKSELG---NDCSKHGTE --WSWKIHPADSPHRNGAAEAAVRTVKRALHNLGG--N-----GVF----TWGEF----- --QTF-----LYMASNLANERP--------IDA------------R-------------- ----------------------TQSREDC------------------------------- ----------- >125/1-545 ---PTKRNILSVASRLFDPLGLLCPLITRAKILLQQ-LWRQ-K----------L------ -DWDE-S-VPM--SLHTSWNHFKQNLFELD---K-ITIP--RYI--G------------- --LP-T-HK--SV-QIHG-FADASGE-AYG-CCIYIR--TSDG-KN------VVS--K-- LLTA---------------------------KSRV-APL-------K------------- ---T----------------------------KSIPRLELCAAL-LLS-TLWAQVKPL-- -LDK----F-M-I---ESV---NF---------WS------------------------- ---------------------------------------IPHQCV-------LRTD-SKT TKL-RVVFDASSKTS-TS---ISLNETLMVGATIQ--RELYATLARFR---LNRF--ALT ADISKMYRQVQVAEE--DRNFQL-----I------LWRDK---A-NV---------DV-Q TYRLNTVTYGTASAPFLAIRC-LVEL------------A----DVY-AESH--P-IASQV T-KND--FYVDDM-LTGAN-S---LEDLERIRLEVC-EV-LESG-------GFKLA-KWA SNHP-QL-LSDSGQEKSLQFD--------------------------------------- PSSSV-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------RR ARPFLICGVDFCGPFY-------------------------------------------- ----------------------------VSLK--IRGR---PLI------KT-SVA---V -FVCFV--SKAVHLELVADLSTDSF-----LSVFKRF-IGRR-GLPEKVYSDNATNFVGA SKVLN-E-------LHQAYQRD-Q--------------------DRLK---AYAARQGVE ----WYFIPPRAPHFGGLWEAAVKSAKQRLVRGVG--N-----AKL----TADEL----- --CTH-----LVEVEALLNSRP--------IAS------------P-------------- ----------------------GN--------DPS--D-------G-------------- ----------- >1251/1-563 ----TKRIVLADTARLFDPLGLVGPVVVVAKMFVQE-LWKQ-K----------C------ -DWDE-P-LPE--AFQSSWIEYRRNLSALS---S-FAIP--RWV--A------------- --FSTD-LA--SV-QVHG-FCDASNK-AYG-ACLYLR--STTF-SG------SVEV-R-- LITA---------------------------KSKV-APL--E-DLKR------------- ---KKRV-------------------------QTTPRLELSGAL-VLS-HLYEKFVAS-- -T-A----I---Q---HTA---YF---------WT------------------------- -----------------------------------AIYYLPHHAV-------LKPD-STT TKL-RVVFHASCKTS-TG---VSLNDALMVGPVVQ--DDLLAIQLRFR---LHRL--AIV ADVEKMYRMILVYPS--DQRLQC-----I------LWRNS---P-NE---------PI-R TYQLSTVTYGTACAPYLATKC-LQRL------------A----ELE-SEKY--P-EAAKV L-KED--FYVDDM-LTGAD-N---VEAATQLMNEMI-EL-TSSG-------GFNLR-KWN SNSS-EP-LDQLPSNLVDSRP--A-L-ELD---------------------------S-- ANTPV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------SP APPFLRVGVDYCGPFL-------------------------------------------- ----------------------------IKYP--VRRA---AAT------KH-FVA---I -FVCLV--TKAVHFELASDLTSEAF-----LAAFKRF-VARR-GKPVLVMCDNATNFVGA KRKLD-E-------LRQLFIEQ-TF------------------QDSVV---RGTIEDGVE ----FRFIPARSPNFGGLWEAAVKSFKGHFKRTIG--D-----RVL----QYDEM----- --ITV-----LPQIEAILNSRP--------LTP------------V-------------- ----------------------SN--------DPA--D-------F-------------- ----------- >1253/1-544 ----TKRAVLRFIASCYDPIGILTPVTLYGKLFFQK-LAH-KE----------M------ -QWDD-S-LTP--DQHKAVQKILQQFEA-P---P-WHVP--RRF--F------------- ---QGLLQFPTTV-ELHV-FTDASTI-AYG-TVAYLR--GL-DNQQ-------VDT-Q-- FLMS---------------------------KSRV-VPL--K------TN---------- --------------------------------YTIPALEMLAIL-TGV-RLANYCLSN-- -L------Q-LTFG----A---YI---------WS------------------------- --------------------------------------YLGHHPV-------FKQ-DSKS TKI-RIVFDGSAKSS-KS--AHSLNDVLHTGQRLL--PDTAALFLRIR---QFII--LLS ADIEKAFLQLSLHLE--DRDATR-----F------LWI-------------NPATNKV-I CYRYRRVPFGLKSSPFLLNKS-VKTR------------L-------ESSNN--P-MA-QK M-INS--FYVDNA-FIGVN-T---FEEAKEVCEFAR-TL-FKTA-------QMNLC-QWF SNNA-QF-NKYIADSQ-NTPP--------------------------------------- EARLQ-----------------KV--LG-------------------------------- -----ITX---------------------------------------------------- ----------------------------------------------------------EP SKPFTTTGVDYGGPLQ-------------------------------------------- ----------------------------VSIN-GVT--------------QKIWIV---L -FTCLY--SRFTATEIVLDMKSTSF-----LTALRRF-VSIH-DKPTTIICDNASQFTIV SSIRN---------ILQNELQQSP---------------------------SIC-STSLP ---EFHFIPAHSPWAGGVYERMMSLIKKTLVRAGT------TKRLL----SLEDF----- --RTT-----LAECTTIINYRP--------LSY------------V-------------- ----------------------SS-------------DDDISPIRPVDY----------- ----------- >1255/1-594 ----TKRVIASQVSSMFDPLGFVCPTITKAKIKLQA-LWRM-Q----------I------ -DWDA-P-VPE--AVVRDWMEFKQRLTGFD---R-LRIP--RHV--I------------- --RPGS-KC--L--ELHG-FCDVSEN-AFG-ACIYLR--SISE-DK------KCTV-R-- LLTA---------------------------KSKV-API--N-I---------------- --------------------------------NTIPRLELCGAR-LLA-KLLCQVLES-- -Y-A----I---D---APV---YL---------WT------------------------- -------------------------------------YFLPHHAV-------MKPD-STT TKL-RTVFDASCRSK-SG---LSLNDVLLPGPTIQ--DTLVKIVMRFR---FHQF--VVC ADIEKMFRQILVHPS--DQPLQR-----I------LWRDD---P-AL---------PL-K ELQLLTVTYGTNSAPFLSTRV-LQQL------------A----DDE-EHQF--P-LAAQA L-RRD--FYVDNL-LSGSD-D---ESALTASCKQLV-EM-LASA-------GLPLR-QWS SNSQ-AV-LAAIPPELHEKSA--I-R-DL----------------------------D-- HEASV-----------------TT--LG-------------------------------- -----LRWEPNTDFLLFKPPHWKESPVLTKRVIASQVSSMFDPLGFVC------------ ----------------------------------------------------------NQ AHPFENVGVDLAGPIY-------------------------------------------- ----------------------------ICSSLRNHRN---PII------KA-YIV---V -YVCLA--TKAVHLDLVTDLTTDAF-----IACLRRF-CGRR-GLPANVYCDNGTNFVGA HKELE-D-------LRKLFLTQ-RH------------------QDAVA---RDCADSGIH ----FHFIPPRSPTFGGIWEACVKSVKHLLRRVVG--D-----AHL----LESEM----- --QTV-----LIQIEGQLNSRP--------IVP------------L-------------- ----------------------PA--------SPS--D-------E-------------- ----------- >1259/1-567 ---YTRRGLLSVVNSLYDPLGFVAPITVQGKLLLRE-LTAN-A----------T------ -DWDS-P-LPA--SGQELWDSWKNSLQELQ---H-IQVP--RSY--G------------- -LVSPSG--AKFT-ELSV-FSDASEK-IIA-AVAYLK--TVDS-NG------NCHA-G-- FITG---------------------------KARL-APL--P-E---------------- --------------------------------LSIPRLELCAAV-LSV-NMMETIIAE-- -I------A-IRF---DEI---NL---------YT------------------------- -------------------------------------WYLPSFGV-------YHPK-K-P SQM-RVVFDSSAL-Y-KG---VSLNKVLLTGPDLN--NSLLGVLMRFR---KEPV--AFM VDIQQMFHCFRVRPA--DRNYLR-----F------LWFHE---NNPE---------NELT EYSMKVHVFGNSPSPAVAIYC-LRCA------------A----QEG-ETDF--GEDARQF V-EED--FYMDDG-LKSLP-S---PEMAISLLKRTQ-DM-LAGS-------NLKLH-KLA SNSK-KV-MQAF-------SSEDYANSLKELD-----------------------LGVNS -LPMQ-----------------RT--LG-------------------------------- -----LLWNLETDCFNFQV----------------------------------------- ----------------------------------------------------------SA EPPFTHVGLDVFGPWS-------------------------------------------- ----------------------------VC--AR-RTRGGFA-ES-----KR-WAV---L -FTCLN--IRAIHIEVIESLTTSSF-----INALRRF-LAIR-GPVKQIRSDRGTNFIGA CKDLQ-I-------PSN-VDEK-A----------------------VE---RFLSDHNCT ----WTFNPPHSSHMGGTWERIIGLTRKILDSMLL--QT--SSSRL----THEVL----- --STF-----MAEVTVIINNRP--------L--------------I-------------- ----------------------PV-------------ST--------------------- ----------- >126/1-559 ----TKRNVLSQIARLFDPLGLISPVIVLAKSIMQQ-LWAD-G----------L------ -DWDE-K-LEN--ELLNRWMTFYQSLVQLN---E-IQVP--RCV--V------------- --IP-G-AH--RI-EIHG-FCDASGT-AYG-ACLYLR--CVQE-NG------EVSV-R-- LLCS---------------------------KSRI-APL-------R------------- ---R----------------------------LTMPRLELCAAV-VLA-RLISVVLPI-- -L-K----L-E-V---DDI---RL---------WS------------------------- ---------------------------------------FPHHAV-------LKPS-SSS TKL-RVVFDGKAKS--NG---LSLNDVLMIGPKIQ--SDLFSIVLRFR---KHLY--AFS ADVEKMYRQVKIDPS--QTHYQR-----I------FWRDN---P-TE---------PI-R VMELSTVTYGTAPASFLAVRS-MIQL------------A----RDE-MTNF--P-EAAEA I-LED--CYMDDI-LSGSS-T---LESTRQLRCDIA-DL-LMKG-------KFPIR-KWC SNDD-EV-LEGIPDEDREKLV------RIE---------------------------ESG ANETI-----------------RA--LG-------------------------------- -----VLW---------------------------------------------------- ----------------------------------------------------------NS AAAFEFTGVDYAGPVT-------------------------------------------- ----------------------------VK--EGRYKP---KQI------KA-YIA---L -FVCLA--TKSIHLELVSDLTTEAF-----LSALDRF-VNRR-GLVRKMMSDNATNFVGA SKELH-Q-------LFLMFRDE-TE------------------KAKID---DFLLKRDIE ----WEFIPPRSPNFGGLWEAGVKVIKSHLHRTLG--N-----AIL----TFEEF----- --GTV-----LTHIEAVVNSRP--------LYS------------M-------------- ----------------------SD--------DPN--D-------PLPITPAHL------ ----------- >1260/1-545 ---PTKRQCASRMAETFDPLGLLAPLLVQFKLFLQD-LW-IDG----------L------ -QWKD-K-IPK--DLLPRWEIIRKQFSEVS-----ISIP--RML---------------- ---R-PRGDYERV-HFIV-FSDASKD-TYA-CATYLL--YEY-ANG------PPKI-G-- LLAA---------------------------KSKV-KPAAST-T---------------- --------------------------------LTIPRLELLAIE-IGS-RIAESAIAA-- -M------G---NETPSTI---RF---------FS------------------------- ------------------------------------TYYIPHRVV-------VKL-ASLT TKL-RIVLDASSKKS-GE---YSLNDCLEPGPSML--IDLLDILIRSR---LSDY--LVV ADIEKAFHQVRMTPG--DRNCTR-----F------LWLKD---I-SK----PATRNNI-V EYRFTRIPFGMTCSPFLLAAT-INHY------------L-------NEMNN--E-IG-ER I-RQN--LYVDNV-MLTTN-K---KEEIQDLRVKSR-AA-FTSM-------GMNLR-EFI TNRL-DE-MAKFPSDEV--A---------------------------------------- AETII-----------------KL--LG-------------------------------- -----YQW---------------------------------------------------- ----------------------------------------------------------TP STPFQHVGLDYLGPLE-------------------------------------------- ----------------------------FIRDDGYKVG------------KA-YCL---V -YTCLV--TRAAHLELLPDASTETY-----IQGLINI-FSRR-GVPHSIYSDNAATFTLG ARIIS-D-------NIRL----------YA-P-----------SQSMI---CFLAHHQIE ----FRHITPLAPWQGGIYERIVGVVKHQMRKEIG--R-----STK----SFFVL----- --SHV-----LTRIENMINSRP--------LTP------------N-------------- ----------------------PR-------------E-------I-------------- ----------- >1261/1-549 ----TRRGLLSVISSVYDPLGYASPFVLKAKMILQE-LTRM-N----------L------ -GWDD-K-IPD--AERRQWDEWIDELPKMA---D-FKVN--RCI--K------------- -PHDFGE--VTEY-ELHH-FSDASER-AYG-SASYIV--MKNG-DG------LAHS-S-- LLVA---------------------------KSHL-TPI--K-R---------------- --------------------------------VTIPRLELMAAT-LSV-KLDSMLRRE-- -L------E-LPI---VRS---VF---------WT------------------------- ---------------K---------------PDSGNVWYLPHHPV-------MTDK-K-P DKV-RIVFDCASK-C-QG---VSLNDVVLQGPDLT--NNLLGVLVRFR---QQPV--ALM ADIEGMFHQVRVPLT--ERDVMR-----F------LWWPG---GDLE---------RQPK MYRMCVHLFGGTWSPSCCNFA-LHQT------------A----ADH-PDAF--TPEAGRA I-HRS--FYVDDC-LVSVN-N---EENAVRLAASLK-EG-LTKG-------GFNLT-KWL SNRP-RV-LESV-------PKEDRSKNAKGLD-----------------------LTHDA -LPV-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PG KPPFSHVGVDCFGPFF-------------------------------------------- ----------------------------VK--QG-R-----S-RL-----KR-YGC---I -FTCLV--IRAVHIEILHTMNTDSF-----LNALERF-ISRR-GRPELIRCDNGTNFVGA ERELR-E-------GGKRWNQQ-K----------------------IH---ANLLQRGID ----WRFNTPTASHAGGAWERQIRTTRKVMNGVMK--L---Q--VL----DDEGL----- --PTL-----MCKVESIINGRP--------LTV------------V-------------- ----------------------S------------------------TDM---------- ----------- >1262/1-521 ----TMRKVLKTIASCYDPQGMLTPTTLAGKLFFQR-LTA-KM----------N------ --WDT-P-LTL--ELDTFWKKVMKDWSG-E---P-WTIQ--RKL--F------------- --SKQQWSRATSV-QLHV-FTDASKA-AYG-AVAYIR--MLVDDE--------ALT-Q-- LLMS---------------------------KSRV-APL--K------PS---------- --------------------------------HSIPQLEMLAIL-TGV-RLGNYICKE-- -M------D-TTFD---EM---FL---------WS------------------------- --------------------------------------------------------SSKS TKM-RIVFDGSAKRS-KK--DKSLNDHLLPGANLL--PDVAAVLLRSR---LKDV--LII ADIQKAFLQMELNIE--DRDATR-----F------LWV-------------NADTGQT-E CYRYARVPFGLKSSPFLLNST-IKLL------------L-------EQQDN--P-FA-ET M-ARS--VYVDDV-FVGVD-T---VEEAKEYYHVSK-RI-FAGA-------QMNLC-KYV SNSP-EA-NRYFTEQE-KTEP--------------------------------------- ETAKQ-----------------RL--LG-------------------------------- -----IDW---------------------------------------------------- ----------------------------------------------------------TP SKPFENTGVDFAGPLK-------------------------------------------- ----------------------------VLIN-DRI--------------VEIYFV---L -FTCLF--SRYVHTEVVKDMETTTF-----LHVLRRF-AARF-GIPKSITSDNAPQFKML SAVLE---------ELK--LQQGT---------------------------GMVNTTSLP ---TFHFIPAHSPWAGGVYERMIGLVKRSLVRAGS------TKVLM----SYEDF----- --VTT-----LSECTAIVNHRP--------LTY------------V-------------- ----------------------A------------------------------------- ----------- >1265/1-580 ---NTKRTVLSDTAKIFDPLGLLGPVIVVAKLFIQE-LWSR-D----------V------ -NWDE-R-LTA--DQEDRWKRFTQELQSIN---E-LLIS--RRA--I------------- --AK-D-AV--AF-EIHG-FSDASQK-AYG-ACVYLR--SIKA-DG------TAEI-H-- LLSS---------------------------KTRV-APL-------P------------- ---KRPGSKRSGKP------------------FTIPRAELCGAL-LLA-RLVVAVIDA-- -M-D----L-E-G---NAV---VL---------WC------------------------- ------------------------------EDGDSRGCYLPHHAI-------LRPA-SST TKL-RVVFDASARSD-TN---LSFNDVLITGPVVQ--DSLMAIVLRFR---RYKY--VFT ADIVKMYRQIRVDES--DSPYQK-----I------LWREC---P-QE---------PL-V TLELMTVTYGTSCAPFCAKAC-LNQL------------A----NDE-ETNF--P-IASKV V-RKD--FYMDDV-LSGAD-E---LPKALECQDQLI-AL-LHRG-------GFKLH-KWC ANAP-EL-LERFPVTDREVQA------KIE---------------------------DRT PNEII-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------NP SPVFYNTGIDYAGPFF-------------------------------------------- ----------------------------VR--QGVRRA---TKV------KV-YVA---L -FICMS--TKAIHLEVVSDLTTAAF-----LAALHRF-VGRR-GCPEKLVSDNAINFQGA QSELQ-E-------LHRLFQAQ-QF------------------REEVN---HFCAAKEIQ ----WSFIPPRSPNFGGIWEAGVKAAKSHLKIVLC--E-----ASL----NYEEM----- --STL-----LVQIEAILNSRP--------LTQ------------N-------------- ----------------------ST--------DAN--D-------LTALTPGHF------ ----------- >1268/1-564 ----TKQLILSIIATLFDPLGLLGASLVLLKMFMQK-LWTL-Q----------R-VDGTR YDWKD-P-LPP--TVGEEWRKLSQHLGVLN---N-IRIP--RCT--V------------- --IK-G-AV--DI-QIHC-YTDASEK-AYG-ACVYIR--SKNV-ER------KLAR-R-- LLTS---------------------------KSKV-APL-------K------------- ---Q----------------------------QPLPRLELNGSD-LGA-DLVEWVIRV-- -L-G----K-R-----FPV---FY---------WT------------------------- ------------------------------PANDSPRCFLPHHPV-------VREE-STT TKV-RVVFDASAKTS-TG---LSLNDVLLVGPTIQ--PDLRDIVLRSR---MRQV--MVV SDVEKMFRQIDMAPE--DSPYQS-----I------LYRFN---P-EE---------EI-A TYELTTVTYGTKPAPFLATRT-LKQL------------A----QDE-QQRF--P-LAAQA L-ETD--VYMDDV-ISGAD-D---VATATELRAQLD-SL-LGSG-------GFKLR-KWA SNEP-SV-LRGVARENLALPD--E-I-DWD---------------------------Q-- -EASV-----------------NT--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TV SRPFSQTGVDYFGPVY-------------------------------------------- ----------------------------VKAG--RGRQ---P-T------KA-YVA---L -FVCMA--TKAVHMELVTDLSTECF-----LQALRRF-ISRR-NRPTDIYSDNGTNFVGA KNVLE-Q-------LLKQLKDV-SH------------------HEKIA---RVCELEGIR ----WHFNPPSAPHFGGLWEAAVRSAKHHLLRVLG--E-----NSA----SFEDY----- --NTL-----LTQVEACMNSRP--------LTA------------L-------------- ----------------------SN--------DPT--D-------L-------------- ----------- >127/1-544 ---PTKRGILRCVMSQFDPLGLLSHFLIHGRVIIQD-IWRS-K----------A------ -DWDD-T-INE--EILERWRVWTTKFKELE---Q-IQIS--RAY--F------------- -PGVTSS-DIEDL-QLHV-FVDGSET-AYA-CVAYFR--ATI--NG------KFEC-A-- LVGG---------------------------KAKV-APL--K-A---------------- --------------------------------LSIPRLELQAAV-IGC-RLMKTLCSS-- -H------S-LPI---SKR---ML---------WT------------------------- -------------------------------------WFLPVGIV-------RNPK-K-P NKL-RIVWDAAAT-V-NG---VSLNSMLLKGPDLV--QPLPNVLCGFR---ERKI--AVV GDIMEMFHQLKIRKE--DRYSQL-----F------LWPNE---T-GP---------D-PK IFVIDVATFGSTSSPCSAQFV-KNLN------------A----TEH-AEAY--P-RAAEA I-VRR--HYVDDY-LESFD-S---EEEACQVIEEVK-LV-HRLG-------GFTIR-NWL SNST-AV-LRRV--G--EAET----KTIKIVD-----------------------D-SGS QV--E-----------------RV--LG-------------------------------- -----MQW---------------------------------------------------- ----------------------------------------------------------PY TRPFSFVGLDYFGPIQ-------------------------------------------- ----------------------------VK--VG-R-----S-LV-----KR-WVA---L -FTCLT--IRAVHLEVVHSLSTEAC-----KMAIRRF-VVRR-GAPLEIRSDNGTNFLGA SHELI-Q-Q------IQE-INQ-H----------------------LS---AVFTNATTK ----WVFNPPSAPHMGGSWERLVRSIKIAFSA-LT--T---T-KNP----DDETL----- --LTL-----MIEAEGIVNSRP--------LTF------------V-------------- ----------------------PL-------------ET--------------------- ----------- >1271/1-533 ---TTRRGILSVVSSIFDPLGLVAPCILPAKLILRQ-LCKD-K----------L------ -GWDQ-D-IPE--KQAQKWLLWKKRDXNLS---S-FSVS--RCF--K------------- -PTDFGP--TMSA-QLHH-FADASEN-GYG-TASYLL--ISNE-HG------EKHC-S-- FVMG---------------------------KSRV-APL--K-Q---------------- --------------------------------ITIPRMELTAAV-VAA-KMDRMLKQE-- -L------Q-LQL---EDS---VF---------WT------------------------- ---------------L---------------ECPSKVWYIPHHGI-------YHPK-K-- NKL-RVVFDCTAT-Y-QN---FSLNSQLMQGPDLT--NTLIGVLNRFR---QEPV--AIM ADIESMFYQVRVPEA--DADLLR-----F------LWWPE---GDLS---------KPMA EYRMKVHLFGATSSPSCACFA-LRKT------------A----MDK-KTEG--TAEAINT I-LQN--FYMDDC-LKSVA-S---EDAAIQLAQSLM-SV-CSKG-------GFHLT-KWV SNSR-SG-LLSL-------PE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PD NPPFTHTGVDYFGPFL-------------------------------------------- ----------------------------IK--RG-R-----S-LV-----KR-YGV---L -FTCLT--VRAVHIEVANSLDTSSC-----INAIRRF-ICRR-GQVSTIRSDNGTNFIGA ERELK-E-------AMRDLDQS-K----------------------IA---ESLVRKGIK ----WIFNTPAASHQGGVWERQIRTVRKVLNSVLN--Q---Q--VL----DDEGL----- --YTV-----LCEVEAIINDRP--------LTN------------A-------------- ----------------------SD-------------D--------PNDL---------- ----------- >1275/1-520 ----TKRSLLSVAQKIFDPIGLACPVTLVPKLLLQA-AWLL-K----------C------ -RWDG-D-LPI--ELKKRFNAWLKTVAWLR---E-CQIP--RNI--C------------- -------ITWEEV-SMHV-FCDASKD-AYA-ACVFIR----SRCGD------SVIV-R-- LVQA---------------------------RSRV-SPI--K-A---------------- --------------------------------MTIPRLELMAAV-IAT-RLGVATKRA-- -L------S-MEF----KS---YY---------WS------------------------- -----------------------------------DCHYLPHHMI-------LKE-TSAT TKV-RPVFDASAKDK-NG---VSLNECLERGPNMI--ELIPQIVIKFR---KYAI--AVI ADIEKAFLQMSLYEK--DRDFMR-----F------LWWKR---Q-------A--EGEI-Q IYRHCRVIFGVSSSPFLLAAT-IAHH------------FEQA---PPHLRE--T-AG--K L-KES--LYVDNC-LTSVE-N---TSDLTKFINEAK-EL-MNLA-------HFNLR-EWN ---S-NC-NDP------TV----------------------------------------- ----------------------N------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------EA SSVFEVTGVDMAGPLH-------------------------------------------- ----------------------------LKG-----------GK------KC-WIA---L -FTCAM--YRALHLEIVQELSTGAF-----IAALRRF-IARR-GRVCTIFSDNGTNFVGT SNALR-G-------LDW---------------------------EKIV---EFAQVNRID ----WKFNPPAAPWWGGWWERLVRMIKDLLKRILG--R-----TTV----TYEEL----- --NTI-----ICDCEATINSRP--------LTY------------I-------------- ----------------------SD--------DVD--Q-------MRALTPAMF------ ----------- >128/1-557 -----RRDVVSEIFRIFDPLGLFAPVVMKAKIFMQH-LTKE-G----------F------ -DYKE-A-LPV--HLQEEWKRYREELKLLN---S-IQVP--RHI--F------------- --QGQI-PI--SS-EIHT-FVDASEK-AFG-AAVYIR--AIHK-DK------RATI-Q-- LLCA---------------------------KSHL-API--N-A---------------- --------------------------------ITLPRLELKAAV-LGA-QLTAKVKEE-- -L-S----M---E---DAST--FF---------WS------------------------- -----------------------------------SRYFIPHHCV-------MKHD-SST KKL-RVVFDASSVTS-SG---KSLNDLMHTGPTVQ--SSIFSILLRFR---MHKY--VFT ADIEKMYRQIWVNPE--DQYYQT-----I------VWRND---P-SE---------DL-R YYRLKTVTYGTKAAPYLATKC-LQYL------------A----QKG-KREY--P-AGAAA L-EKD--FYVDDC-LTGAD-T---IPEALQKQKELN-QL-LQNS-------GFKLR-KWC TNNV-HI-LQNIPKEDMIPNVQLE-DTTYE------------------------------ -DCSV-----------------KT--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------TQ ARPFLNSGVDYCGPFK-------------------------------------------- ----------------------------IHYK--IRGK---KPN------TA-YIA---I -FCCFA--TKAVHLELVSDLTTEAF-----LAALRRF-ISRR-GKCQVLHCDNATNFVGA RNKLQ-E-------LEEAIFSE-KA------------------KEHIV---RECNNKGVQ ----FKFIPPRAPHFGGLWEAAVKSAKHLLLKNVT--T-----ANL----TYEEL----- --ETV-----IVEIEAILNSRP--------LTP------------I-------------- ----------------------SD--------NPN--D-------V-------------- ----------- >1284/1-556 ---FTKRTILAATCKIFDPLGLLSACTIVPKMLLQR-LWKS-K----------L------ -DWDD-L-VSA--DVSKEWSDFVNNLKQIK---A-INIP--RHV--F------------- -HTSSDTPV--SV-QLHC-FVDSSQS-AFA-ACVFIR--CTDS-GD------KVSV-K-- LLCA---------------------------KARV-APL--K-P---------------- --------------------------------STIPRLELAAAL-LGA-QLSSKVCQS-- -L------S-RKI---DQK---YF---------WT------------------------- ------------------------------SAYKGNKK---------------KKK-KKK KKL-RVVFNGSARTA-SG---KSLNDIQYSGPVVQ--NDLMSILLRFR---QHKY--VLS GDIEKMFRQVMLDEA--QRHLQL-----I------LWRDN---E-TQ---------PL-R TLQLNTVTYGTASAPYLTTRC-LVQL------------S----TEC-SDKR-----VANI I-KND--FYCDDL-ITGCD-N---KTELKYLRDAVV-DK-LAEA-------CLPLR-KFR TNIP-SI-FASDPISTICTEK--DLSQANDQY-----------------------S-NLQ NQSS-------------------V--LG-------------------------------- -----LNW---------------------------------------------------- ----------------------------------------------------------TL TYPFLVTGVDFGGPFS-------------------------------------------- ----------------------------IMDR--KGRG---CKVS-----KC-WLS---L -FVCLS--TKALTLEVVSGLSTEAF-----LMCFRRF-ISRR-GKPHDIYCDNGTNFVGA NNELG-----------RMLRAS-QS--------------------SVI---AAAHDEGIK ----FHFSPAYSPHWRGLNEAGIRSAKLLMKRVIG--N-----ANL----TFEEL----- --TTL-----FTQIEAILNSRP--------LTP------------L-------------- ----------------------TS--------DPS--D-------M-------------- ----------- >1287/1-523 ---PTMRNVYRVLASQYDPIGFIIPYTTRAKVLIQA-LWKK-D----------R------ -GWDT-PIEGN---LLSLWQNWEDELIYLQ---E-VTLP--RCY--F------------- -PRNVSS-LSAAV-DLHI-FCDASEE-AYG-SVAYLR--VEDE-QG------HIHV-S-- FVMA---------------------------RSRV-APK--K-Q---------------- --------------------------------LSMPRLELCAAL-TGA-QLARVLQTE-- -L------S-LSV---RQT---IL---------WS------------------------- ---------------A---------------NKTPESWYIPHHMV-------YHN----- RKA-RVVFNCSYR-Y-QQ---ACLNDNLLPGPTLG--PSLLGVLLRFR---EHAV--AIS GDIKAMFHQVRLLPE--DQPLLR-----F------LW-RN---MERE---------RSPD IYEWRVLPFGTTCSPCCAIYA-LQRY------------V----RDH-KVG---NEDVMES V-LHS--FYVDNC-LQSFH-T---TNQAKEFPNKLX-AF-LAAG-------GFEIR-QWA SNVP-DV-ITH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LF KPPFWSTGVDCFGPYH-------------------------------------------- ----------------------------VK--IG-R-----R-HE-----KR-WGI---V -FKCLT--TRCVHLDLLCNMDTDSF-----LLALRRF-VARR-GKPYELLSDQGTNFRGG ERELQ-E-------AFASLTPE------------------------LQ---EQLAKQKID ----FKFNPPHAPHFGGAWEREIKSIKASLQVVLK--D---T--IL----PEEVL----- --RTV-----LIEVEGIMNSKP--------LGY------------V-------------- ----------------------SS-------------DV--------------------- ----------- >1289/1-543 ----TKRNILAAISKIYDPIGLISPVLIQAKLLLQK-IFE-AN----------Y------ -KWDA-P-IEQ--SFCLEWNKIMLTWKESP---E-IKIP--RFL--G------------- ------NKQINSQ-EFHC-FTDASKY-GFG-AAIYVK--T---SEE------GSHP-G-- LIFS---------------------------KSLI-KPA--S---LPSNA---------- --------------------------------TTIPKLELQALT-LGA-KMIKFLQNE-- -L------N-FNMA---QA---TI---------WS------------------------- ---------------------------------------LPHRAV-------IKI-DKNT TKL-RIVMDASARPP-SQKDAPSLNDCLHTGPLLL--KQLAGILLRFR---FMKR--VIL ADIEKAFLQLGVRET--DRDCTR-----F------LWVEN---P-EQINLENFQYAQC-L VFRFCRVSFGLTVSPFLLNAT-IREH------------L-------SLFDT--K-VE-RT I-EEN--LYVDNI-MIEVE-P---EEDVNALCFQAI-DI-FKSG-------GMKLR-EFF GLTR-KE-SRGMSEDLL--IR--------------------------------------- NQIET-----------------KI--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------TM ARPFCYCGIDYFGPIN-------------------------------------------- ----------------------------VKG--QNVVK------------KV-YGA---L -FTCLT--IRAIHIELVEDVSTKSF-----IQAYRRF-VARR-GTPSIIASDNATNFTMG SKIIK-E--------------L-NK---ELIF-----------SQEVQ---EMIKYQGTE ----WKFITPRNPREGGAWERMIGITKTAMKRSIG--K-----SLL----TDTEL----- --STL-----FCELEAIVNSRP--------LTY------------Q-------------- ----------------------S------------------------------------- ----------- >129/1-556 ---ATRRGILSIVASLFDPLGFLAPFVLKGKTILQE-MCRS-G----------M------ -GWDD-N-LPA--DLQSAWEHWKADLVNLE---K-IEVP--RCI--V------------- -PSGFGR--IIRR-EIHH-FSDASMS-GYG-QCSYLR--LENE-QG------DISC-S-- LLMA---------------------------KSRV-APL--K-I---------------- --------------------------------TTIPRLELAAAV-VSV-AVNDMLKEE-- -M------N-LAD---AEA---FF---------WT------------------------- ---------------E---------------GREGERWYIPHHGV-------YHSK-K-P GKL-RIVFDCSAR-Y-KG---TSLNDHLLTGPDLM--NSLTGILLRFR---QYPV--ALM CDVEKMFHQFHVDHA--DRDYLR-----F------LWWRN---GDFN---------SQPQ TFRMTVHLFGASSSPGCANYG-LKHL------------A----REG-ERLY--PLGS-QF I-MQD--FYMDDG-VSSIE-S---TEKAIKLAEEAR-QL-CALG-------SLRLH-KFV SNDK-EV-LKTI-------PPSECAVDVTAVD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SPPFTYSGMDVFGPFI-------------------------------------------- ----------------------------TS--KG-R-----K-SN-----KR-YGL---L -FTCFC--CRAIHIEMLDDMSTDAF-----INGLRCF-IAIR-GAVHQIRCDQGSNFIGA RNELT-K-------AMEEIDTN-R----------------------LV---TFLAEKQCD ----FVFNAPHSSHTGGVWERQIRTVRSVLRSTLS--Q---SSGRL----DDSSL----- --RTF-----FYEAMSIVNSRP--------LTV------------D-------------- ----------------------SL--------T----DPSSPEPLTPNHL---------- ----------- >1292/1-555 ---STKRSILSNIARLFDPLGXLSPVTVTAKVLMQD-LWIQ-K----------C------ -DWDT-P-LPE--DFRERXYAYCKSLSELP---S-LSID--RWL--G------------- -VTSTR-----SY-QLHG-FSDASSR-AYA-AAVYLR--VDKG-DG------TFSV-S-- LLAA---------------------------KTKV-SPV-------K------------- ---T----------------------------VSIPNLELCGAA-LLV-KFLCHVRKL-- -D------F-LSA---TPV---FA---------WS------------------------- ---------------------------------------LPHHPV-------VLYL-LLK MKI-RVIFDASRRTR-DG---WFLNHFLFTGAPLQ--SDLALILLNWR---RYLF--VFT ADIVKMFRQIKVQRE--DQDFQR-----I------VWAPT---A-DS---------PP-V DYRLTTVTYGTACAPFLAIRT-LQQL------------V----EDE-GARF--P-LGAEC L-KSE--TYVDDT-FAGSD-E---LSTAVQKRVELT-KL-LGSA-------GIYLD-KWA ANHP-EL-LPPQTGQGPAKEI------DMD------------------------------ --ESV-----------------KT--LG-------------------------------- -----VHW---------------------------------------------------- ----------------------------------------------------------HA SRPFSISGLDYAGPIQ-------------------------------------------- ----------------------------VRTT--KGRG---HKAY-----KW-YIV---V -FVCFS--TRAIHLELVSDLTTATF-----ISAYRRF-VGRR-GVCQKLYSDNATNFHGA DNELK-A-------MFQRASDF-YQ--------------------KVA---SVLANDGTE ----WVFIPPSAPHYGGLWEAGVNSVKHHLKRVVG--E-----HTL----TFEEL----- --STV-----LVEIEACLNSRP--------LGA------------L-------------- ----------------------TS--------DID--D-------LHALTPFHF------ ----------- >1293/1-574 ---MTRRGILATVNSVFDPLGFTAPFLXPAKVLMQD-LCRL-K----------L------ -NWDE-P-IPH--NHDVAWIKWKNDLHKLE---T-YSVN--RCI--K------------- -PTDFNK--ITSS-QLHH-FSDASME-AYG-SVTYLR--LTNS-ND------RIFC-A-- QLFG---------------------------KCRL-VPL--K-K---------------- --------------------------------LTVPRLELCAAT-MSV-RTDKFMKRE-- -L------E-LPMVF-QPS---VF---------WT------------------------- ---------------N---------------GNNGRIWYVPHHGI-------YHPK-K-P DKI-RVVFDCSAK-Y-KG---ICLNDVLLQGPDLT--NSLIAVLCRFR---QEHV--AIM GDIQSMFHQVRIPEQ--DQDLLR-----F------LWWKD---GDIN---------NELQ TFKMKVYLFGTVCSPSCSNFA-LQQT------------A----RDN-CELF--RAEVTNT V-ANN--FYVDDC-LKSVA-T---AAEPITLVKDLS-QL-LHKG-------GFNIT-KWL SNSR-EV-LSSI-------PKSHQSKVVKDLN-----------------------LSTDR -LPAD-----------------TA--LG-------------------------------- -----LQWSVDQDTFGFTY----------------------------------------- ----------------------------------------------------------PD LCSFTNVGIDFFGPFT-------------------------------------------- ----------------------------VR--QG-R-----S-TP-----KR-YGI---I -FTCLT--LRVIHLEVAHSLDTSSF-----IQGLRRF-ISRR-GQVSEIRSDNGTNLVGG ERELR-E-------ATQKWNQH-Q----------------------IN---DFLLQRNIK ----WIFNAPTASHHGGAWERSIRTVRKILSAVSR--E---Q--TL----NDESL----- --CTL-----FCEVEAIINGRP--------LTC------------V-------------- ----------------------SN-------------D--------PNDL---------- ----------- >1296/1-548 ---PTKRDVASKLAETFDPLGLVSPIMVAFKRLIQK-LW-SHD----------M------ -NWKD-K-IPV--ELLPDWHNLQKSFQDTL-----VVIP--RQL---------------- ---T-DHYDYDRA-ELLI-FSDASQD-IYA-CMAYTC--FLK-KGC------EPRV-Q-- LLAS---------------------------KNKI-RPSKNE-K---------------- --------------------------------WTIPKLELLGIE-CGS-TLACNIIAE-- -L------R---IKI-DGI---RL---------FT------------------------- -----------------------------------PVYFIPHRAV-------FKE-DSLT TKL-RVVLDASSHAR-GQ---LSLNDCLHAGTNMI--TPIFGILLRTR---CTKF--IIV ADIAKAFHQVKLQEE--FRNVTC-----F------LWLKD---I-HK----PPTDNNI-M VYRSTVIPFGVSSSPFLLAAY-ITYN------------L-------DNNPD--D-IN-KD I-RDN--LYVDNA-LFGTN-D---PDKIMPIIRKTK-AT-FANM-------SMNLR-EYC VNHD-KI-MDTLDPSVA--T---------------------------------------- SAEAI-----------------KL--LG-------------------------------- -----YTW---------------------------------------------------- ----------------------------------------------------------IS SKPFSKVGLDYLGPVE-------------------------------------------- ----------------------------YIKDDGVTIG------------KA-YVL---I -YTCMC--TRGAILRVVPDSTSYRY-----VMTLKMI-FREV-GVPLAVYSDNAAAFRLG ASVIN-A-------DIAS----------FE-Y-----------STTLT---TFLASESVD ----YKFIVPLAPWQGGVYERVVQIVKRQIRKECG--N-----AKF----DYHSL----- --QYL-----VSGAQGMINNRP--------LTP------------H-------------- ----------------------SR--------SPG--D-------M-------------- ----------- >1297/1-524 ---PTLRNVYKVLASQYDPIGYLIPFTTRAKVLVQD-LWKT-N----------L------ -TWDD-PITSE--SLLSRWQTWLQELQGLN---H-IAVP--RCY--S------------- -PSGWQA-DKLNR-ELHI-FCDASER-VYG-SVAYMR--TEND-QG------HVHI-S-- FVLA---------------------------RSRV-APR--K-Q---------------- --------------------------------MTIPRLELSAAL-TGA-QVANILQEE-- -L------T-VDI---NRI---IL---------WS------------------------- ---------------A---------------EESRESWYIPHHMV-------THN----- GKD-RIVFNCSYS-Y-QG---QALNDILLPGPILG--PSLLGVLLRFR---EHPV--AIS GDVKGMFHQVRLLPT--DKSVVR-----F------LW-RD---MQRS---------NQPK IYEWQVLPFGTTCSPCCAIYA-LQMI------------A----QTH-SDG---DPVLEST V-KGS--FYVDNC-LHSLQ-T---VAEARALVDNLR-QL-LLTC-------GFELR-QWA SNKP-EV-IQH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LY KPPFYSAGMDCFGPFT-------------------------------------------- ----------------------------VK--IG-R-----R-TE-----KR-WGI---V -FKCLT--TRCIHLDLVESLDTDAF-----LMALRRF-ISRR-GKPFELLSDNGTNFVGG DKELR-A-------AYESMIPQ------------------------LR---EQLAEQQIT ----FRFIPPGAPHFGGVWEREVKSVKQALKVVLK--D---L--TV----TETVL----- --RTV-----LIEVEGILNAKP--------LGY------------V-------------- ----------------------SS-------------DV--------------------- ----------- >13/1-551 ---YTKREVLSQIARLFDPAGWLAPFIIRSKMFMQE-IWLQ-N----------L------ -GWDD-K-LPT--EMSQRWQSFLDEYSDLN---Q-IRVP--RWI--W------------- -YQPEV-----II-EHHG-FCDASQR-AYG-AAIYIR--VEMG-QK------I-LT-R-- LLTA---------------------------KTRV-APV-------K------------- ---T----------------------------VSLPRLELCGAV-LLT-EMVTAILPH-- -M------P-SAS---SDI---RC---------WT------------------------- ------------------------------P-----SYHLPHHAV-------VKPE-STT TKL-RVVFNASSPSA-NG---TSLNDILHAGPVLQ--SDLTIQVLKWR---YFQY--VFS ADITKMYRQIWVDPK--HTPFQR-----I------LFR-N---K-EG---------DI-R DFELKTVTFGVNCAPFLAIRV-LQQL------------A----EDI-QVPF--P-NASRI I-QQH--MYVDDV-LAGAN-S---VNEAQSSIRELQ-AA-LSAS-------GFPLR-KWT SNNK-SV-LKDVPAEHLLHSE----FLDID------------------------------ AESTA-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------SF SRAFTYTGIDYAGPFE-------------------------------------------- ----------------------------IKNY--TGRA---CLIT-----KG-YVC---V -FVCFS--TKAIHLEPTSDLTTEKF-----LAAFARF-VARR-GCPQRVHSDNGKTFVGA ATLISRD-------FLQAI------------------------KESVT---DAYSHQGLV ----WRFIPPGAPHMGGLWEAGVKSFKTLFLKSTS--A-----RKY----TFEEL----- --ATL-----LAKIEACLNSRP--------LSP------------M-------------- ----------------------SE--------DPS--D-------L-------------- ----------- >130/1-569 ---ATRRGILSIVSSLYDPIGFVAPFLLKGKCILQE-LCQR-N----------M------ -EWDD-S-LPD--DLIPRWEEWKNSLQDLK---D-FTVP--RCY--Y------------- -PSSFSK--IVLT-ELHH-FSDASNL-GYG-ACSYLR--VKSD-KN------EVHC-C-- LVMA---------------------------KARV-API--K-I---------------- --------------------------------KSIPRLELAAAV-VSA-RLSVLLKAE-- -L------Q-MMI---DQE---FF---------WS------------------------- ---------------I---------------PDKETAWYIPHHGV-------YHPH-K-P DKL-RVVFDCSSK-F-CG---ISLNDTLLTGPDLI--NSLVGVLCRFR---KEAV--AVT CDIEKMFHQFHVPPE--ERDYLR-----F------LWWKN---GDLK---------EEPI EYRMTVHLFGAASSPGCANFG-LKYL------------A----EKY-KSEY--SEAS-SF V-NNN--FYVDDG-LISVP-S---IQEAKDLIAEAK-TL-CKLG-------GLRLH-KFN SNEK-DV-LRCV-------DSSEWAVSSKPLN-----------------------LTPES -S--G-----------------HV--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------EA SSPFCYTGMDCFGPFI-------------------------------------------- ----------------------------IK--KG-R-----K-EY-----KR-YGL---L -FTCLS--SRAVHIEMLEDLSTDMF-----INALRCF-ISLR-GAVRQLYCDCGTNFVGA RNEFK-Q-------ALKECDVK-T----------------------LE---RYLAENQCE ----FIFNAASASHSGGVWERQIRTVRNVLNSTLS--L---CPGRL----DDSSL----- --RTL-----FYEAMAIVNSRP--------LTV------------D-------------- ----------------------GI--------N----DPKSLEPLTPNHL---------- ----------- >1301/1-528 -----RRTVSSDMASKFDPMGYLTPLLLPPKLFQRE-LW-D-T----------T-----Q YGWDT-K-LSE--QHEDEYRKLIQNINGFT-----IKMP--REI--V------------- -LKTGKN-------SIIT-FCDASKE-ATA-CCVYVK-------ND-------KGT-H-- IILG---------------------------KSHA-RPLKEK------------------ --------------------------------WTIPKLEMHALL-LGT-EKTMKVVKA-- -LQLGQT---------------------------T------------------------- -------------------------------------HYNALQAV-------ITP-SKTT TKC-RIVVDASAHYK-DK---PCLNDCIEQGPTIL--PDIQDMIIRFR---SGQT--VLI SDVEKAFLQVFLHED--DRDVTR-----V------LWFKD---I-NK----PVNEDNI-I VYRFTRVLFGLNVSPFLLGQT-IIHH------------L------RSLKDD--P-II-RE M-PHN--LYVDNS-IITTDEN---AENVIQIYKKVK-KT-FKDA-------NMNLR-EFR SNCK-TV-NDGIAEEDK--S---------------------------------------- KEEDM-----------------KV--LG-------------------------------- -----IWW---------------------------------------------------- ----------------------------------------------------------NK QRPFGSTGLDNFGPIQ-------------------------------------------- ----------------------------YRKD-DGTLA------------NA-YGT---I -FTCTT--TRLIHVETVKNASALEF-----IQAFRKF-VAIR-GRPTKIVSDNGTNFVLG QKIIE-E---------AF--E-------RSDC-----------PPD---------MHKID ----WKFITPYAPWKGGVYERMVKSVKEAFYKAVG--R-----SKL----TFEEL----- --TTV-----LYEATASINQRP--------LTK------------L-------------- ----------------------ED--------DIN--A-------EA------------- ----------- >1302/1-537 ---PTKREVLRVLMSIYDPLGLISHYMMFLKVTLQD-VWRT-G----------I------ -HWDA-A-IEE--KQFKNWKTWVKLLPNLE---K-LSIP--RCY--R------------- -QVTSAC-ETTIV-QMHT-MVDASIN-GMA-AVVYLR--FEE--KG------KVEC-V-- LVTG---------------------------KTRV-APL--K-Y---------------- --------------------------------LSIPRLELQAAV-LGC-RLAESVSNN-- -L------S-IKI---SRR---LF---------WT------------------------- -----------------------------------RVWYLPIFPV-------KNLN-K-P NKF-RIVWDAAAS-V-HG---VSLNSALLTGPDEL--VSLPSVLQTFR---QFRV--AVV GDIREMYHQVRMRLP--DQHCQR-----F------FFRN----D-KS---------EELS VYVMQVMTFGACCSPATAQYV-KNRN------------A----ERF-QIDY--P-RATDA I-INK--HYVDDM-LVSEE-T---EEAAIDLAITVR-RI-HAKA-------GFEIR-NWL SNSS-KV-AAAL--NG---ASTE---EKDLNL-----------------------TAE-L ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY TRPFSHVGVDYFGPYL-------------------------------------------- ----------------------------IT--VG-R-----R-TE-----KR-WGV---L -LTCLT--TRVVHIEVAYSLTTSSC-----IIALRNF-IARR-GTPLAFYSDRGTNFVGA QKELQ-K-------ASELLEQN-K----------------------IA---CEFTSPRTS ----WHFNPPSSPHMGGSWERLIQSVKRNLQEIQG------T-RRL----SDEEL----- --RNA-----LTEIEFTLNCRP--------LTH------------V-------------- ----------------------PI-------------DD--------------------- ----------- >1305/1-570 ---ATRRGILSTVASVYDPLGFLAPFMISAKKVLQE-MCHK-G----------I------ -SWDE-P-LPI--EMRPRWESWLEDLSKLD---K-IQIP--RCF--T------------- -PSNFGK--ILRT-ELHH-FSDASNK-GYG-QCSYIR--LLSD-T-------RVHC-A-- FIMG---------------------------KARV-APL--K-V---------------- --------------------------------VTIPRLELTAAV-VSA-AVSGMLKEE-- -L------A-LKV---DGE---YF---------WT------------------------- ---------------E---------------PSMGHLWYIPHQGV-------YHPK-R-P NKI-RVVFDCSAK-Y-EG---TALNEHLLTGPDLT--NGLTGVLCRFR---KYPV--AVM CDIKKMFHRFHVARE--DRDFLR-----F------LWWPN---CDTN---------AEPR EYRMRVHLFGASSSPGCANYG-LKYL------------A----SIN-ETEY--PLAA-SF I-RRN--FYVDDG-LVSVE-S---AESAIKLVEEAQ-AL-CAKG-------KLHLH-KFL SNSR-EV-LESI-------NQSDHAVEVKNVD-----------------------FYHNH -LPVQ-----------------NV--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------DS SPPFTYCGMDCFGPFY-------------------------------------------- ----------------------------IK--QG-R-----K-EC-----KR-YGL---L -FTGLC--SRAVHIEMLEDMTTDAF-----INALRCF-ISIR-GAVRHIRSDQGTNFVGA KRELR-N-------ALKEVSKE-R----------------------VA---VYLAANQCD ----FCLNAPSSSHAGGIWERQIRTIKAILNSVLR--Q---SAGRL----NDASL----- --RTF-----FYETMSIVNNRP--------LTV------------E-------------- ----------------------GL--------S----DPTSLEPLTPNHL---------- ----------- >1308/1-538 -----RRTVASRLAGIYDPCGTMVPLLLPLKLVQRK-LWDD-Q----------------- YGWDT-P-VKE--ELTKEVRQILEAMEGFK-----IQLP--RMV--I------------- -NKSGNN-------RLVT-FTDASKE-ATA-CCVYVI-------RE-------GHA-A-- LVMA---------------------------KSKV-RPLKEK------------------ --------------------------------WTTPKLEMQALT-MGV-KLTKKVRRA-- -LFDGEILI-------DSA---IL---------LS------------------------- -----------------------------------------------------TP-HKST TKC-REVIDGSSHFK-NQ---PSLNDSIYPGPVIL--PDLCEMLVRFR---AGKI--VIL SDVEKAFLQVRLHED--DRDATR-----L------LWIKD---I-RK----LATKDNI-I IFRFTRVLFGLNVSPFLLAAT-IQHH------------L------ESHPNQ--K-LA-KE M-ALN--LYVDNL-MLTSDEK---PDKAINLYYEAK-KT-FLEM-------NMNLR-EFL SNSK-DF-NEKVDHKDR--A---------------------------------------- PDANM-----------------KV--LG-------------------------------- -----IRWFSIPD----------------------------------------------- ----------------------------------------------------------TV NSPFEKTGLDYFGPIA-------------------------------------------- ----------------------------YKLK-DGTVG------------KA-HGC---I -FTCTV--TRLIHVEIVTDETTKSF-----IQAFRRF-ISLR-QLPKRVISDNAPTFVLG NKIIN-E---------AL--T-------ENSL-----------SKEVQ---EFLGIQGIT ----WTFITPYAPWKGGFYERMVRSVKTAFIKGIR--T-----NTL----DLDEL----- --ATC-----FAEITESINSRP--------LTY------------V-------------- ----------------------EN--------DLN--S-------------IEV------ ----------- >131/1-550 ---PTKRQLLKFMMGIFDPLGFLSPITIHLKIIFQE-LWRL-Q----------S------ -GWDD-E-IPD--GLVPRWVEWLNETARLK---E-VRLP--RYY--F------------- -PEIPS---FADA-EFHA-FCDASDK-AFA-CVIY----MVHRHKG------TSHV-A-- LVYA---------------------------KSRV-APL--K-S---------------- --------------------------------STVPRLELQGCV-LAS-QMMKTLQDE-- -M------K-IEV---TKL---FF---------WT------------------------- -----------------------------------NTWYLPHFSV-------ESAG-K-- --F-RLVMDAKAK-S-HG---FSLNDLLLKGPDLV--PALIAILMRAR---KKKI--GFV ADIKEMFHQILIRRM--DQDSQR-----F------FFRGM---DRSE---------SPSS VYIMMVMIFGAVSSPSMAQFI-KNFN------------A----KEM-EEEY--P-GVERA V-IDQ--HYVDDY-FDCAD-T---DEEAIELVQRVV-ET-HDHG-------GFQLV-KFS SNSE-AF-LDSL--------------DPALVA-----------------------DRVGS RT--------------------RV--LG-------------------------------- -----IDW---------------------------------------------------- ----------------------------------------------------------PP SFPFTNTGIDYFGPLV-------------------------------------------- ----------------------------VK--VG-RISRHPR-LE-----KR-WVV---L -FTCLT--SRAIHLEVVPDLDTNSC-----IMAIRCF-MSIR-GLPQCIMTDNGTNFTGA DQELK-R-------LVKTLDQP-QH------------------IRAIE---DSMSIRGVQ ----WKFIPPGAPHFGGCWERLVRSVKNALRAMLQ--E-----RHP----TDLVL----- --RTT-----LCEVMNTVNNRP--------LTH------------V-------------- -------------------SSDPL-------------DA--------------------- ----------- >1314/1-540 ---MTKRELLSLIHTVYDPLGLIGPVLLPAKLLYQK-VCA-RN----------I------ -NWND-K-LEE--MELNEINQIIEGWGE-Q---E-FSRP--RKI--I------------- ----HGCENAEIL-QIHC-FVDSSMK-AYA-VNIYLR--IACPHQ--------INT-S-- LIFA---------------------------KNRI-VPK--G----KEKT---------- --------------------------------LTIPRLELLAIL-IGT-RAISFVTKE-- -I------K-QPIE---KT---ML---------WS------------------------- ----------------------------------------------------------SF TKL-RVVFDAGS----GK---TPLNNELLRGAVLL--PQLPGILIRTQ---MFNN--LLI ADIAKAFLQIQLRQE--DRDVTR-----F------LWVKD---I-KH----QPEYQNL-I SYRFTRVLFGVISSPFLLIAT-ILHH------------L------EKIKS---P-LS-EE I-KTN--LYMDNI-ILGAK-N---TDEIKEKYTELI-KI-FEKA-------KMKVR-EFC SNSV-EG-NKMFVEADKHPSI--------------------------------------- ESKSL-----------------KF--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------IP SRVFQNTGLDFMGPII-------------------------------------------- ----------------------------VKDI-DEERS------------KR-WIL---L -LTCLS--TRTIHLEVVTSISTHAF-----LNAFRKF-VARR-TRPDYILSDNGSSFRLA EKTLK-R--------------I-KP---DQII-----------DDGIQ---KYFAKENIN ----WKFITPLAPWEGGIYERINGMIKSNIRKSIG--R-----KLV----DNDDF----- --NTL-----ICEVEAIINCRP--------LVQ------------I-------------- ----------------------DD--------EQE--T-------I-ILRPIDF------ ----------- >1319/1-547 ---PTKREIARVVMSFFDPLGFIAFFLVHGKAILQD-TWVK-G----------T------ -EWDQ-K-IPE--DLNERWRQWSGLFHQLN---Q-LHIP--RCY--F------------- -RSSFPK-NLDAL-QLHL-FVDASEA-AYA-GVVYFR--LES--EK------GVQV-S-- LVGA---------------------------KVKV-APL--K-T---------------- --------------------------------LSIPRLELKAAV-LGI-RLQEAIQSQ-- -H------T-FPI---SRR---FC---------WS------------------------- -------------------------------------WYLPLGVV-------INPR-K-P DKI-RLIWDAAAK-V-GN---TSFNSRLLKGPDLL--SPLPRVLYKFR---QHPV--AVC GDIMEMFHQIRIRSP--DCQSQR-----F------LFREH---S-SD---------S-PQ VYVMDVATFGSTCSPASAQFI-KNLN------------A----DEF-ASEY--P-RAAVA I-KFH--HYVDDY-LDSFE-S---VTEAVTVVNEVK-LV-HSKG-------GFTLR-RFL SNEA-EV-LQKI--GEF----SEQA-PKNLDL-----------------------E-RGG KS--E-----------------SV--LG-------------------------------- -----IKWMPFED----------------------------------------------- ----------------------------------------------------------SF IRPFTYTGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-HA-----KR-WVA---L -FTCLT--IRAIHMEVVHSLSTESC-----IMAVQRF-VSRR-GIPTEFWTDNATTFQGT SNEIK------------A-TKQ-A----------------------LA---QKFTTTQTT ----WKFIPPASPHMGGAWERLVRSVKQTIGTVLD--E---S-RKP----DDETL----- --ETV-----LLEAEAMINSRP--------LTF------------I-------------- ----------------------PL-------------ES--------------------- ----------- >132/1-550 ----TKRVILSGISQLFDPLGIVSPVVIRAKMLMQL-LWLQ-P----------C------ -GWDD-P-VSE--SIASKWKSYAEQLPNLS---N-FHVP--RYA--L------------- --LP-K-AT---I-QLHS-FSDASES-AYG-ACTYAR--SLDS-HG------NITV-H-- LLAS---------------------------KSRV-SPL-------K------------- ---R----------------------------ISLPRLELCAAD-LAT-KLHSKISEA-- -L-Q----I-D-I---SAS---YF---------WC------------------------- -------------------------------------CFLPHHPV-------MKDS-STT TKV-RVVFDASAKTS-SG---HSLNEALLVGPVVQ--DDLHAICLRFR---TFPV--AVV SDVAKMYRQILHHPD--DTPFQQ-----I------LFRFD---K-TD---------PV-Q TYRLLTVTYGMAPSAFLATRT-LIQL------------A----DDE-GHTY--P-LGGPA I-RKG--FYVDDF-IGGAQ-S---IQEAIQLRTELG-EL-MAKG-------GFCLR-KWT SNKL-EV-LQGLESDQIGTQS--A-I-QFD---------------------------K-- -DETI-----------------KA--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------RP SRPFSITGVDFAGPVY-------------------------------------------- ----------------------------LKAI--HKRA---QPA------KA-YIC---I -FVCFS--TKAVHIELVGDLSTSAF-----LAAFRRF-VSRR-GRPSDVYSDNGKNFEGA KNTLE-E-------VYRLLQDN-AE--------------------SIH---SFCATETIN ----WHLCPPKAPHFGGLWEAAVKVAKTHLYRQLG--N-----SRL----TFEEM----- --ATL-----LTQIEAAMNSRP--------LVP------------L-------------- ----------------------SE--------DPN--D-------L-------------- ----------- >1321/1-518 ----TLRNVYRVLATQYDPIGFLIPFTTRAKVLLQQ-LWVK-E----------R------ -QWDD-PVLPE--GIQKAWAAXENELPDIT---S-IQLS--RTY--G------------- -PVELDS-TSVKR-ELHV-FCDASEQ-AYG-SVAYLR--IVND-D-------KVLV-S-- FVMA---------------------------RSRV-APR--K-S---------------- --------------------------------ISIPRLELCAAL-TGV-QLANLLERE-- -L------D-LNI---QRT---IL---------WS------------------------- -----------------------------------ESWFVPLHLV-------KHN----- EKY-SLVLNCSYV-F-KG---DSLNTHLLPGPTLG--SSLLGVLLRFR---ENPV--AIS CDIKSMFHQVRLLPS--DKPLVR-----F------LW-RN---MRKE---------EPAD VYEWHVLPFGTTCSPCCATYA-LQKH------------V----RDL-SEN---CEDLKDS I-TKA--FYVDNC-LQSVS-D---IQKGKELVEKLR-AH-LKEG-------GFEIR-QWA SNVL-EV-VEV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LF KPLFWSTGMDCFGPFT-------------------------------------------- ----------------------------VK--TG-R-----K-TG-----KR-WGL---L -FKCQT--TRCVHLELLTGLDTDSF-----LMALRRF-VARR-GQPYEVICDQGTNFHGG ESELK-N-------AFEHLSPV------------------------LK---EKLWNHQIK ----FTYNPPYAPHFGGTWEREIRSIKSALRSTLG--S---Q--TV----KEEVL----- --ATV-----LVEVEEILNSKP--------LGY------------V-------------- ----------------------SS-------------SAE-------------------- ----------- >1322/1-547 ---PTKRIVLSCVMSLFDPLGLLAPFTVYGKILIQD-LWRS-G----------T------ -EWDE-I-IDI--ECLEKWKNWIRRLPEVE---E-IRVP--RYH--F------------- -TKGSEV-ELKTL-QLHV-FVDASQY-AYG-CAAYFR--VLMA-GQ-------PVC-S-- LVMA---------------------------KSKV-APL--K-Q---------------- --------------------------------LTIPRLELQAAV-LGA-RLMNTVIDT-- -H------T-LAI---TEC---FI---------WS------------------------- -------------------------------------WYLPLNVV-------VNPK-K-P EKI-RLVWDAAAT-V-EG---ISLNSQLLKGPDML--SSLPSVISRFR---EREV--GFG GDIREMYHQLLIRKD--DKQYQR-----F------LYRND---A-ES---------S-VD VYVMDVATFGATCSPCSAQFV-KNKN------------A----NEA-AEKY--P-DAARA I-VDN--HYVDDY-FDSTD-T---VEEAIQRSKEVR-YV-HSCA-------GFEIR-NXV ANCD-EI-LQSL--GE-----PKVEQQVHFNQ-----------------------D-KDT GT--E-----------------R------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PY KRPFSYTGVDYFGPVT-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WIA---L -FTCLT--TRAVHLEVAHSLSAQSC-----IMTIRRF-ICRR-GSPIEFFSDNGTNFKSA SKEI-----------LRN-IDV-E----------------------CG---EIFTDATTR ----WNFIPPSAPHMGGAWERLVRSVKAALSE-LD--D---G-KKL----TDEIL----- --LTT-----IIEAEDLVNSRP--------LTY------------L----PLDSGSETAL T---------------------PN-------------QF--------------------- ----------- >1324/1-521 ---PTKREMLRTLMAIFDPLGLISNLLIFLKILLQE-VWRS-R----------V------ -GWDD-Q-IPD--ELKDKWELWLRYFPAVH---S-VSIP--RCY--R------------- -AMVRLE-DDTNV-QLHT-FVDASEL-GYA-TVIYLR--FEQ--QG------KVEC-M-- IVSA---------------------------KARV-APL--Q-F---------------- --------------------------------VSIPRLELQAAV-IGS-RLAETIVNS-- -L------S-FKV---NQR---FY---------WT------------------------- -----------------------------------RIWYLPIFPV-------FNPN-K-P GKL-RIVWDAAAK-S-QG---ISLNMMLLKGPDQL--TSLNSVLYKFR---ENKV--AIC GDIKEMFHQTVIKEE--DQNCQR-----F------LWREH---P-ND---------LEPS TFVMQVMTFRACCSPSCAQYA-KNVN------------A----REH-EEEY--P-DAAEA I-IKK--HYVDDM-LASVE-T---EDEAIKLAQDVR-HV-HAKA-------GYEMR-NWL SNSS-TV-LNSL--N--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF TRPFSFIGVDYFGPLY-------------------------------------------- ----------------------------VT--VG-R-----R-LE-----KR-WGV---L -VTCLT--VRAIHVEIAHSLNADSC-----IMALRNF-MARR-GVPIRIFSDRGTNFVAS SKELE-A-------ALREMDQD-K----------------------VI---HEIVSPDTE ----WEFLPPASPHMGGCWERLVRSVKVNLQKMKP------Q-RNH----SDESL----- --RNT-----LTEIENIINSRP--------LTF------------V-------------- ----------------------SV------------------------------------ ----------- >1327/1-532 ----TRRTVLGTISSCFDPMGLVGPCLLPAKAFFQH-LWTLEN----------F------ -EWDT-V-LPQ--EESRTWEKLTSDWIT-----E-ISIP--RLV--L------------- ----H-GDSPT-V-QIHT-FTDASDF-AFG-TAVYLR--SENKKDG------RITS-S-- LVFS---------------------------KNRL-RPL--K----ANSK---------- --------------------------------LTIPRLELLGIL-AGV-RAAKFVQQE-- -L------H-RELE---KT---FV---------WS------------------------- -----------------------------------QEHFLPHHAV-------FNK--G-- -KI-RLVYDASAHPK-GL---PSLNQSLFRGPVLL--PNLINLLLRFR---STKI--PVL ADIEKAFHQISLIES--DREFCK-----F------LWLKN---M-DQ----PLSPSNL-A VYRFKRIAFGIISSPYILAAV-IRHH------------L------SKERT---D-LA-NE I-KEN--IYVDNV-LLECD-T---REEALDKCKAAK-QM-FATA-------KMNLR-EFC THER-AV-LDQISLEDR--L---------------------------------------- EQDIP-----------------RV--LG-------------------------------- -----INW---------------------------------------------------- ----------------------------------------------------------FR KMIFESVGLDYAGPS--------------------------------------------- ----------------------------SVRI-NGIIT------------KF-YLL---L -FCCLT--TRAIHLEITLSQSAVAF-----MNAFQRF-ISRR-GKPKRVISDNAPSFILA DKTID-F--------------L--I---NE----------------PS---NELAQKGID ----WTFIPAYSPWAGGMYERLVGITKQLFQRTLG--K-----GIL----HYDDL----- --ITF-----TAKVEATLNLRP--------IST------------V-------------- ----------------------SD--------E--------------------------- ----------- >1328/1-557 ---PTKREVLRTLMMIFDPLGLIGHFLMYLKAVLQE-IWRT-S----------V------ -GWDD-A-IEE--KQYQMWVEWLNVLPKVA---E-VEIP--RCY--R------------- -SATSIG-HSNDV-QLHV-FVDASET-GFA-AVAYLR--FQE--GQ------TIET-S-- LVGS---------------------------KTRV-API--K-F---------------- --------------------------------LSIPRSELQACV-IGL-RFANSIVQS-- -L------S-IKV---NKR---FF---------WT------------------------- -----------------------------------RDWYLPVFPV-------LNPN-K-P GKV-RLVWDAAAA-A-YG---VSLNSLLLKGPDLL--TSLLSVLVKFR---QFRV--AVC GDIREMYLQVLLKQD--IRLC-------F------FWKDD---Q-NI---------EKPS TYAMSVLPFGVSCAPSIAQFV-KNTN------------A----KQF-AEEH--P-AAVDA I-VDK--HYVDDM-LVSVE-S---EKEAIELAKNVR-KI-HAEA-------GFEMR-NWI SNCP-QV-LQAL--GE---SKTV---EKNLNI-----------------------SEG-L VT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY ARPFTYMGVDYFGPYV-------------------------------------------- ----------------------------VI--LG-R-----R-LE-----KR-WVL---L -ATCLT--TRAIHLQIVHTLNTDSC-----IMAIRNV-MARR-GIPAVIYSDQGTNFRGA SKELE-E-------AMKNLNQE-R----------------------LA---EEFNSPHTS ----WNFNPPASPHMGGAWERLVRIVKQNLAKLKP------N-RTV----SHEVL----- --ENM-----LMEVENIVNSRP--------LTS------------L-------------- ----------------------PL-------------DDDQSPVLTPNHF---------- ----------- >133/1-552 ---PTKREVLRVVMSIFDPIGLVAVYVVHGKVLVQH-IWRS-G----------I------ -GWDE-R-IPD--GLLEQWKRWIKLLQQLD---H-VEIP--RCY--F------------- -PGYSPE-HYRAV-ELHI-FVDASEE-AFA-AVAYFR--IVE--GS------RVRC-S-- LVSA---------------------------KTKV-APL--K-L---------------- --------------------------------LSIPRLELSAAV-LGA-RLAKSVMEN-- -H------T-IPI---SHK---VF---------WS------------------------- ---------------S---------------FDPKRTWFLPLNVV-------TNPR-K-P NKV-RLVWDAAAK-V-QG---QSFNSALLAGPDFL--APLQAVLSSFR---QFEV--AIS ADICEMFHQILIRPE--DRSAQL-----F------LWRDE---P-SK---------P-FE VFVMDVATFGSTCSPCAAQFV-KNRN------------A----EEY-SEQF--P-LAAEA I-IKH--HYVDDF-LCSVH-S---EQEAVELAEQVK-LV-HSKA-------GFVIR-NWL SNSK-SV-LTRV--GE-QQAV----PEKKTWT-----------------------D-RSV VN--E-----------------RV--LG-------------------------------- -----MIW---------------------------------------------------- ----------------------------------------------------------SH VRPFTYVGVDYFGPML-------------------------------------------- ----------------------------VK--QG-R-----S-EV-----KR-WVA---L -FTCLT--IRAVHLEVVHNLTTESC-----KMAIRRF-IARR-GAPREIFSDRGTNFVGA NRDLK-M-E------LRQ-INT-N----------------------LA---STFTNTDTQ ----WRFNPPSTPHMGGSWERMVRSVKSALAS-LS--T---G-GKP----DDETL----- --RTL-----LAEAESIVNSRP--------LTY------------L-------------- ----------------------PI-------------DS--------------------- ----------- >1331/1-554 ---NTKHQLLSDSAKLFDPFGWFAPVIVRVKILYQK-CWLY-D----------L------ -NWHD-K-LPP--TIEEAWVEVKESLHLLE---R-VKLP--R-W--S------------- -ANYNGR--I----ELHG-FSDASEE-AYS-AVVYLR--SVES-NN------EVHV-T-- LLAA---------------------------KTKV-APV--H-Q---------------- --------------------------------ISIPRLELNAAE-LLA-KLMKQVAAP-- -L------E-RFQ---IDQ---YA---------WT------------------------- ------------------------------DADCSKSYYLPHHGV-------IKED-SVT TKL-RVVFDGSSTTT-TG---ASLNDILLEAPNIN--ADLFDVLLRFR---SYPV--VFL ADIEKMYRQVLVHPD--DTDYMR-----I------VWRDS---P-DK---------PI-Q HFRLLTVTYGLKNSGFLAMAA-LHKA------------A----EAF-EERY--P-KAAER I-IKH--TYVDDL-TSGAD-S---AEEAIEIIKQIN-EI-LGEA-------GFTLR-KWS SNSP-EV-LDSLSDTISSAMPIQF-PDERN------------------------------ ---TV-----------------KA--LG-------------------------------- -----THW---------------------------------------------------- ----------------------------------------------------------TA CRPFAHVGVDYAGPIS-------------------------------------------- ----------------------------VRCS--NTRG---ARCM-----KG-YIV---V -FICLS--SKAVHLEVAGDLTTDTF-----LGAFKRM-IARR-GYCNEVWSDNGTNLVGA DRQLQ-E-------IYEVVTKH-VK--------------------QGE---HFFTNLGIR ----WRFIPPASPHQGGIWEAAVKSAKELLRPILG--N-----EKL----THEEL----- --STV-----LCQVEACLNSRP--------LCP------------M-------------- ----------------------SS------------------------------------ ----------- >1332/1-606 ---PTMRHIYKVLASQYDPLGYIVPYTTRAKVLVQH-LWDK-K----------R------ -EWDD-PQLPN--ELLHAWQEWEQELPDIQ---H-ISIP--RCY--V------------- -TPELDK-PECIR-NLHI-FCDASER-AYG-SVAYVQ--TLSS-QG------DVEV-A-- FLTA---------------------------RSRV-SPK--K-Q---------------- --------------------------------QSIPRLELCAAL-TGS-QLAKLLKSE-- -L------S-VPI---NQV---TL---------WS------------------------- ---------------V---------------DQAKESWYIPHHMT-------HHN----- GKN-RVVFNCSFQ-N-RG---KNLNQLLLPGPTLG--PSLMSVLLRFR---EHTV--ALS SDIRGMFHQVRLLPD--DRPLLR-----F------LW-RD---LNRD---------QPPQ VYEWQVLPFGTTCSPCCATFA-LQKH------------V----IDH-SQP---GEDVRES I-EKH--FYVDNF-LQSFD-S---QEEARDRASKLH-NL-LATG-------GFDLR-QWA SNFP-QV-LDTI-------PSTAKSNTLVLWL-----------------------AQEQP -DAQE-----------------SA--LG-------------------------------- -----LYWHCTSDKLSYKYRPIKSSTPTMRHIYKVLASQYDPLGYIVPYTTRAKVLVQHL ----------------------------------------------------------LL QPAFYSTGVDCFGPYL-------------------------------------------- ----------------------------IK--IG-R-----R-HE-----KR-WGV---I -FKCMT--TRAVYLDLLCQMDTDSF-----LMALRRF-ISRR-GKPFEIISDQGTNFRGG ERTLK-E-------DFNALSPS------------------------LQ---EQLASHQIN ----FKFNPPGAAHFGGCWEREIRSLKSALCSTIG--D---Q--IV----TEEVL----- --RTM-----LVEIEGILNSKP--------LGY------------T-------------- ----------------------SS-------------DI--------------------- ----------- >1336/1-601 ----TMRKIYRTLAKQYDPLGYLIPFTTRAEIIVQL-LWNK-K----------R------ -GWDD-PCLPA--DLLAAWEEWENELPHLA---Q-ITLP--RCY--S------------- -GI-VQQ-PIKHR-SVHI-FCDASER-AYG-SVAYLS--TEDD-QH------NTQI-A-- FLAA---------------------------RSRV-APK--R-Q---------------- --------------------------------LSIARLELCGAL-TGA-QLGAVLKRE-- -L------T-LEI---HHF---VY---------WT------------------------- ---------------C---------------GLSSHSWYIPHHIV-------HHN----- GKN-RIVFNCSFE-Y-QG---QSLNENLLPGPTLG--PSLLGVLLRFR---EHPI--AVC SDVRGMFHQVRLLDE--DKPFLK-----F------LW-RD---GITS---------EPPT IYQWAVLPFGTTCSPCCAVFA-LQSH------------A-----GI-LES---TDDVRQT V-ERN--FYVDNC-LKSIS-D---VEQAKQLVNRLQ-NH-LSEG-------GFELR-QWA SNDP-TV-IDHF-------PSELKSKGSEIWL-----------------------SQGTT -NPLE-----------------RT--LG-------------------------------- -----LIWNCQSDTLAYKPFQEDKGEITMRKIYRTLAKQYDPLGYLI------------- ----------------------------------------------------------LF KPPFYSTGVDCFGPLM-------------------------------------------- ----------------------------IK--IG-R-----R-TE-----KR-WGI---V -YKCLT--TRAVSLDLLDHMDTDSF-----LLSLRRF-TARR-GRPYELLSDQGTNFRGG NTELE-E-------AFKEMQPL------------------------LR---DQLAKEQIR ----FRFNPPSAPHFGGSWEREVRSVKTALRTTLG--A---Q--IV----TEEVL----- --RTV-----LVEVEGILNSRP--------LGY------------V-------------- ----------------------SS-------------DVADPDPVTPNSL---------- ----------- >1338/1-578 -----KRFVLSSIAKIYDPLGLIDPVKALAKQIMQQ-IWEL-K----------K-TDGKN WDWDD-E-LPS--DLQQAWVHFQQHLEPLR---N-LQIP--RAA--V------------- -HTSIH-----NV-QLHV-FCDASEK-GYG-ACCYIR--DDND-EE------NITS-Q-- LLTS---------------------------KSKI-APL--S-Q--K------------- --------------------------------LTIAQLELCAAK-LGS-DLFAKVKEA-- -IPT--------F---SNV---YF---------WT------------------------- --------------------------------------YIPHHPV-------FKAE-STT TKC-RVVFDASAKTT-SG---YSLNDALMVGPTIQ--QESFTILLRFR---SYII--AAI ADVEKMYRQVWVHPE--DRPMQR-----I------FWRVS---P-NQ---------PI-R TFQLNTVTYGTASAPFLAVRA-LKQI------------I----IDH-GKEF--P-KATE- R-MDD--FYVDDF-ISGAD-S---ITDVQQLYNEAT-TL-LAKG-------GFTLR-KWC SNDP-EA-LIEIG-NIKNV--TMP-ADDVN------------------------------ -G-HV-----------------TT--LG-------------------------------- -----LIWRPRADTFSIKVHIPETIHHLSKRF---------------------------- ----------------------------------------------------------IA SRPFSISGIDYCGPVF-------------------------------------------- ----------------------------VKGA--HRRA---VPT------KA-FVA---I -FICFT--TKAVHIELVSSLTTEAF-----LAALRRF-IGRR-GLVSELHSDNGTNFKGA SNELN-N-------LYRLLHSD-EH------------------QRKMH---SWTLERGID ----WTFIPPRAPHFGGLWESAVKSAKYHLLRTMG--T-----SSY----TFEDM----- --MTI-----LTEVEGCLNSRP--------ITP------------M-------------- ----------------------SD--------NPS--D-------L-------------- ----------- >134/1-536 ---PTKRSILSQIASLFDPLGLLAPIIVKAKLVMQR-MWEL-K----------V------ -AWDA-T-PPG--ELTNDWLVLVQKFSLLN---S-FQIP--RRV--I------------- --DMRN-WT--RL-YLHG-YCDASDV-AMG-ACIYIR--AVGN-DG------STSS-H-- LLCA---------------------------KSKL-API--G-NGR-------------- --------------------------------TTTPRLELCAAV-ILA-RLITNVRAA-- -L-S----T-TIF---YEV---RA---------FS------------------------- ------------------------------------SVYLPHHCV-------VKST-SST TKC-RVVFDASAKTT-SG---LSLNDVLMCGPVVQ--DSLINILVRFR---FPPI--VLV GDAKQMYRMVWLHEL--DRDFLK-----I------LWRWS---K-DD---------PI-E EYRLNTVTFGTKSASYLATKC-VQQL------------L----NSY-REQY--P-AAVEK A-EKG--IYVDDV-LTGAD-S---EEEARLLRDQLI-EM-FGAG-------GFHLR-KWA SNSA-AV-LEGVP----------------------------------------------- ------------------------------------------------------------ -------V---------------------------------------------------- ----------------------------------------------------------KP LPPFAITGVDYAGPVN-------------------------------------------- ----------------------------IVGR--RTRG---AVPS-----KG-YIS---L -FVCLG--TRAVHLEAVSDLSAPSF-----LAAFTRF-TSRY-GVPSKMYSDNATNFRAA ARTLR-E-------LYQQIDAT-EH------------------SDEVN---DFFTDKQVQ ----WLFIPARSPHHGGLWEAGIKVAKTFLNKIGG--N-----YNY----TFEEL----- --STL-----LAQVAACMNSRP--------ISP------------I-------------- ----------------------SD--------DPA--D-------P-------------- ----------- >1347/1-545 ---ATKRKVLSNLATIYDPLGLGSPITVLGKMVYRD-ICDR-G----------L------ -KWDE-P-LPT--EINQRWKAWGSRL--PE---R-IEVP--RSL--P------------- ----DHREPIQAI-DLHG-FGDASGE-GTC-AAVYAV--V-HQ-ES------GVSQ-G-- LIAA---------------------------KSRL-AKK--G------------------ --------------------------------LTIPRLELVSGQ-MVA-RLTDNIRVA-- -L------EGLPL---RNY---YG---------WL------------------------- ------------------------------TATHGREFYIPFKPI-------VREL-AES TKT-RLVYDVSARATADA---PSLNDYLETGAPLQ--NLIFDITACNR---FHPV--TLA GDIRKALMSVRVKEE--DRDALR-----F------HFIDP---C-DP---------DKTT EYRFTRAIFGLNQSPFLLGVT-LEQH-----------------LNTYTDEY--P-KEVDE I-KRS--LYVDDI-LLGGN-T---RVEVTNLRNTVV-KI-FESA-------DFKLH-KWH SNDQ-QLEITESVEPADGDLSFAKQLLKVE------------------------------ -NPET-----------------KL--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------VG ERPFQVVGLDYAGPLP-------------------------------------------- ----------------------------YKS--G--NS---SDG------KA-YIL---L -ITCSL--TRAVHLEVLPNLALEEF-----KQAFTGF-VARR-GRPETIYSDNAKTFFAA SMWIK-K-------IVMS--------------------------EEPC---DYLAKLNIG ----WRFNLSRAPWWGGQFERLVGMMKQSLFKVIV--G-----A--------REL----- --QEV-----ILDIEVSLNNRP--------LTY--------------------------- ------------------------------------------------------------ ----------- >135/1-558 ---PTKREVLRTLMMVFDPLGLIGHFLMVLKTLLQE-IWRS-S----------I------ -GWDE-T-ISD--QHFEKWSTWCAALPGIT---E-IKIP--RCY--R------------- -SLTSVS-ECNEI-QLHV-FVDASEA-GFA-AVAYLR--FQE--GS----G-NIEC-A-- LLGS---------------------------KTRV-SPL--R-F---------------- --------------------------------LSIPRSELQATV-IGV-RLADTICKS-- -L------S-IKV---KQR---FF---------WT------------------------- -----------------------------------RVWYLPIFPV-------VNPN-K-P GKT-RLVWDAAAI-A-YG---VSLNTMLLKGPDLL--TSLLSVLIQFR---EYKI--AVC GDIREMYHQVQIRDV--DQQCQR-----F------FWKEN---I-TD---------AEPS TYIVQVMTFGACCSPSTAQYV-KNLH------------A----GKF-QQEH--P-AASEA I-VKR--HYVDDM-LLSVE-H---EAEAIQLTQDVR-KI-HASA-------GFEIR-NWA SNSP-AV-LDQL--NE---TSEA---EKSF-------------------------SDS-S SF--E-----------------KI--LG-------------------------------- -----MWWNPSSDHFTFKI----------------------------------------- ----------------------------------------------------------AC TRPFTYMGIDYFGPMT-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WGV---L -ATCLT--IRAIHLELAHTLTTDSC-----VLAIRNI-MARR-GTPAVIYSDRGTNFQGA SKELR-E-------AVQNINQD-Q----------------------IL---KEFTTPHTE ----WTFIPPASPHMGGAWERLIRSVKTNLSKLQW------G-RLP----TDEVL----- --HST-----LLEIENVVNSRP--------LTD------------I-------------- ----------------------PI-------------DD--------------------- ----------- >1356/1-550 ---PTKREVLKIVMSLFDPLGFASFFLVHGKVLIQE-IWAS-G----------S------ -HWDQ-P-IKD--EICERWHRWTEMFDQLV---K-LRIP--RSY--F------------- -SSAIPT-EFNNL-QIHI-FVDASEA-AYS-CVGYFR--LDS--ES------GIQV-S-- LIGA---------------------------KTKV-APL--K-T---------------- --------------------------------LSIPRLELKAAV-LGA-RFMESIQAN-- -H------T-FHV---SQK---YY---------WS------------------------- ---------------S---------------SDPSRVWYLPLGIV-------TNPK-K-P DKI-RLIWDASAK-S-DG---VSLNSKLLKGPDLL--TPLPTVLSRFR---QYPV--AVS GDIREMFHQLTVIEP--DQQAQR-----F------LWRED---P-AG---------E-PH IYVMDVLTFGSTSSPSSAQYV-KNLN------------A----SEF-ASEY--P-RAAGA I-LEN--HYVDDY-LDSFA-T---VEDAIRTVNEVK-HI-HSKG-------GFQLR-KFK SNDV-AV-LRGI--GEL----ANDE-CKDLLL-----------------------E-RGE SI--E-----------------SV--LG-------------------------------- -----MKW---------------------------------------------------- ----------------------------------------------------------TF ERPFTFVGLDYFGPVL-------------------------------------------- ----------------------------VR--VG-R-----S-TA-----KR-WIA---L -FTCLS--IRAIHLEVVHSISTESC-----IMAVKRF-VARR-GPPVEIYSDNATCFQGA SNELQ-R----------E-IND-A----------------------LA---LTFTSTNTS ----WKFIPPAAPHMGGVWERLVRSVKVAIASINE--T---C-RKP----DDETL----- --ETI-----VLDAEAMVNARP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >1357/1-544 ----TRRTVLGTISSCFDPMGLVGPCLLPAKAFFQH-LWTLDN----------F------ -EWDT-V-LPP--DESRNWERVTSDWST-----E-ISIP--RLV--L------------- ----Q-GNSLT-V-QIHT-FTDASDF-AFG-TAVYLR--SESREDG------RITT-S-- LVFS---------------------------KNRL-RPL--K----ANSK---------- --------------------------------LTIPRLELLGIL-SGV-RASKFVQRE-- -L------Q-REID---KT---FI---------WS------------------------- -----------------------------------QEHFLPHHAV-------FNK--G-- -KI-RLVYDASAHPK-GL---PSLNQSLFRGPVLL--PNLINLLLRFR---ATKI--PVL ADIERAFHQIALIES--DREFCK-----F------LWVKN---L-DQ----PLSPSNM-A VYRFKRIAFGIISSPYILAAV-IRHH------------L------SKEQT---D-IA-NE I-KEN--IYVDNV-LLECD-S---VEEALIKCKTAK-QI-FSTA-------KMNLR-EFC THER-AV-SDQISPEDR--L---------------------------------------- EQDIP-----------------RV--LG-------------------------------- -----INW---------------------------------------------------- ----------------------------------------------------------FR KMIFESVGLDYAGPS--------------------------------------------- ----------------------------SVRI-NGIIT------------KF-YLL---L -FCCLT--TRAIHLEITLSQSAEAF-----MNAFQRF-ISRR-GKPKRVISDNAPSFILA DKTID-F--------------L--I---NE----------------PS---NELAKKGID ----WTFIPAYSPWAGGMYERLIGITKQLFQRTLG--K-----EIL----HFDDL----- --ITF-----TAKVEATLNLRP--------ISN------------V-------------- ----------------------SD--------EKD--G-------FLPLRPADL------ ----------- >1359/1-534 ---STRRGCLSVIASLYDPLGFIAPFSLTGKRILQE-LCHR-G----------I------ -GWDD-P-LPE--DMMLRWEEWKNGLHKLK---E-VSIP--RCY--H------------- -PYNFHN--IVRV-ELHH-FSDASCV-GYG-ACSYLR--YKND-MD------EVHC-S-- LVLA---------------------------KARV-APS--N-V---------------- --------------------------------TSIPRLELTAAV-VSA-KVSVMLKAE-- -L------D-IRI---DEE---FF---------WT------------------------- -------------------------------------WYLPHHGV-------YHPR-K-P DKL-RVVFDCSAK-F-HG---VSLNDTLLTGPDLI--NPLVGVLCRFR---KEAV--AII CDIERMFYQFSVTPE--ARNYLK-----F------LWWKG---GDLE---------KEPQ EYRMTVHLFGAASSPGCANFG-LKHL------------A----RQH-KATY--PLAS-TF V-EKN--FYVDDG-LVSVS-S---IEEAKKLITESQ-EL-CKRG-------GLRLH-KFN SNEE-AA-L--------------------------------------------------- ------------------------------------------------------------ ---------------TC------------------------------------------- ----------------------------------------------------------EA SAPFTYSGMDCFGPFI-------------------------------------------- ----------------------------VK--KA-R-----K-EY-----KR-YGL---I -FTCLY--SRAVHIEMLEDLSTDSF-----INSLRCF-ISLR-GAVQQLHCDQGSNFVGA RNELK-E-------ALKQCDTK-L----------------------LE---TFLTEKQCE ----FVFNAPSDSQAGGVWERQIRTVRNVLNATFA--Q---CPGRL----DDASL----- --RTL-----LYEAMAIVNSRP--------LTV------------D-------------- ----------------------GI--------N----DPQAPEPITPNHL---------- ----------- >136/1-545 ---PTKREVLRLVMSLFDPLGLIASYIIEGKVIIQE-IWRS-K----------V------ -GWDE-Q-IPV--KLLKRWEQWLEILRALD---K-VKIP--RCY--F------------- -PEYSKA-TYESL-ELHV-FVDASES-AFA-AAAYFR--VVD--NG------RIRC-C-- LVSA---------------------------KTKV-APL--Q-S---------------- --------------------------------IGIPRLELQAAM-IGT-RLMKTITDN-- -H------T-IPI---KRR---VM---------WS------------------------- -------------------------------------WYLPLGIV-------VNPR-K-P NKL-RMVWDAAAV-V-QG---VSFNSVLLTGPDLL--VPLQAVLSRYR---QKKI--AIS ADIMEMFHQVEIRPE--DRQAQR-----F------LWRNN---P-GD---------P-IQ VFVMDVAIFGSTCSPCSTQFA-KNLN------------A----DEH-SAEF--P-EAAVA I-KEN--HYVDDY-LDSVD-S---IDEAVQLATDVK-TV-HSRG-------GFQIR-HWM SNSP-EV-LRRI--GE-QNSL----TVKSFVM-----------------------D-KDS QQ--E-----------------RI--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PY VRAFTFVGIDYFGPLT-------------------------------------------- ----------------------------VR--VG-R-----A-SV-----KR-WVA---L -FTCLT--TRAIHLEVAASLSTDSC-----KQAIRRF-IARR-GAPQEIYSDQGTNFQGV SSELA-R-Q------IRA-ING-A----------------------LA---DTITNHRTQ ----WKFNPPHAPHMGGVWERLVRSVKRGLSC-LL--T---D-RNP----NDETL----- --ATV-----ITEVESMVNSRP--------LTY------------L-------------- ----------------------PL-------------ES--------------------- ----------- >1363/1-533 ---NTRRGILSVVSSLYDPLGIIAPLILPAKMLLQR-LCKN-E----------Y------ -GWDD-V-ICP--DEVRQWQEWVESVRCLS---DCVFLP--RCV--K------------- -PMSLER--IVST-QLHC-FSDASNE-GYG-AVSYLR--IVEN-QG------KISC-N-- ILLG---------------------------KSRV-APL--K-T---------------- --------------------------------VTIPKLELVAAT-VAA-KLQRQISRE-- -L------D-KSI---HET---IM---------WT------------------------- ---------------S---------------EDSYPVWYLPHHPV-------FHAQ-K-P DKC-RVVFDCAAR-Y-SN---TSLNDQLLQGPDLT--NSLVGVLLRFR---QEPI--AVT ADIEKMFHQVLVTPA--DTNALR-----F------LWWPH---GDLT---------KDLE VYKMVVHLFGAXSSPSCASFA-LRKT------------A----EDN-KADF--PKQVSET V-RRN--FYVDDC-LKSVA-T---QEEAKKLVPDLT-TL-LARG-------GFRLT-KWM SNSR-EV-VSSI-------PN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PS TCPFSSVGIDYFGPIQ-------------------------------------------- ----------------------------VK--VK-R-----S-LV-----KR-YGC---I -FTCLA--MRAVHIEVSYDLSTDSF-----LQSFSRF-VSRR-GPPVQVYSDNGTNFKGA ELEVK-N-------ALKLWNXA-R----------------------IE---DNKLE--VE ----WHFNPPKASHYGDVWERMIRSICKILRVLLG--N---Q--VV----DDETL----- --LTV-----MTEVEKILNDRP--------LTC------------V-------------- ----------------------SD-------------D--------PNDL---------- ----------- >1364/1-557 -----KRQMLSTASSIFDPMGFLAPFMVRAKILFQS-LWQL-G----------T------ -FWDE-P-LPD--DVDHLWVKWKQELEELP---L-INVP--RAL--V------------- -PVALVE--AKRV-ELHA-FCDASEL-AYG-AVIYLR--VETS-AP------LALV-N-- LITA---------------------------KTRV-API--K-R---------------- --------------------------------LSLPRLELMGAL-VAA-RLVHYTQRA-- -L------S-LPI---HSI---TC---------XC------------------------- ------------------------------SGPPRRTWYLPHHAV-------YKG-KGEE RKC-RVVFDGSARYG-QT----SLNSQLEAGPPIQ--MDLLRALLRFR---RFRV--GLQ ADIENMYLQVQIREE--DRDVCR-----F------LW--R---D-ET--------QEV-C KYRLTRVCFSLTCSPFLAVST-VRVH------------A----RRHQATAP--R-AA-SE V-LCN--MYVDDL-ATSCE-S---PDEARTLATQLE-EL-MASG-------GFHLH-KWA SNEP-AA-LRAIPTEKRSTET--------------------------------------- RGCLW-----------------KT--LG-------------------------------- -----IYW---------------------------------------------------- ----------------------------------------------------------VE APAFSQVGMDFAGPLY-------------------------------------------- ----------------------------VRV-GRK-T-----TS------PR-YVC---L -ITCMV--TRAVHLELVPQMTTVRV-----LQALRRF-MARR-GRPKIIQSDNFRSFKRA AAEFG-Q-------LWQSID-----------------------VERVQ---RELVGHRIH ----WKFIPDRAPWMGGYWERLVRSVKESLRKVLG--Q-----ALL----DDCEL----- --QTI-----LCEVEACLNARP--------LTF------------V-------------- ----------------------ND--------GPG--D-------PQPLSPFQL------ ----------- >1368/1-559 ---FTRRGVLSTVSSFYDPCGFLSPVMLRGKQILQE-LCRS-K----------L------ -DWDS-P-IPE--DLRPRWERWLQEVLELE---N-LQIP--RCY--K------------- -PRDFGE--VKAV-ELHH-FSDASQE-GYG-QCSYIR--LVNT-QD------KVHC-S-- FVIG---------------------------KSRV-TPL--K-Q---------------- --------------------------------VSIPRLELTAAT-VSA-RMSGFLNQE-- -L------K-YDS---FKE---FF---------WT------------------------- -------------------------------------NYIPHTGV-------YHPR-K-P NKI-RVVFDCSAT-Y-QG---VSLNDMLLQGPNTM--NSLLGVLCRFR---KEAV--AVA ADVKSMFHQFYAAAE--DRDLLR-----F------LWWED---GNPE---------NAVV EYRMKVHLFGAASSPGVATFG-LRRA------------A----DDG-EEEY--GAPAANY I-RTD--FYVDDG-LRSEP-D---VASAIQLLKNSQ-AI-CAKA-------GLTLH-KIV SNER-EV-QESF-------TKKEGLTDKKELG-----------------------LARSP -STLE-----------------RV--LG-------------------------------- -----VVW---------------------------------------------------- ----------------------------------------------------------EP SAPFTYCAVDYFGPFL-------------------------------------------- ----------------------------LK--EK-R-----S-EV-----KR-YGV---L -FTCMS--SRSIHLETANSLSSSSF-----INALRRF-MNRR-GTVRQLRSDQGTTFIGA RNELK-Q-------ALQEMDQK-H----------------------VQ---EYLLENGVE -WIPFKFNVPHSSHMGGVWERQIQTVRRALDTLLA--K---AGSQL----DDESF----- --RTF-----MTEAECIVNSRP--------LTT------------N-------------- ----------------------NL--------S----DAEA------------------- ----------- >137/1-545 ---PTKRIALKIIMSLFDPLGLLAPYLIHGRALIQD-LWRS-G----------V------ -QWDE-K-MRD--EEFEKWTRWVELLPAIS---K-LNIP--RYY--F------------- -GEANRL-CHSTL-QCHV-FTDASES-CYG-AAVYFR--TVDG-SG------RVQC-S-- LVMA---------------------------KSKV-APL--K-H---------------- --------------------------------LSIPRLELEAAV-LGA-KLLHTVQTN-- -H------S-LQP---HEV---YL---------WT------------------------- -------------------------------------WYLPLGLV-------THPK-K-- QKK-RLVWDGKAQ-V-NG---ISLNSQLLKGPDLL--VSLPSVICKFR---EKRV--GFG GDIREMFLQLRMRTA--DKYFQC-----F------LFRFD---P-RQ---------P-PE VYIADVAMFGATCSPCVAQHV-LRVN------------A----DKW-ADEF--P-LAATA I-KNK--TYMDDY-YDSAD-T---PEEAAELAVQVK-TI-HARG-------GFEMR-NWV SNCE-EV-LKKL--GE-----SSSVEPRPL-Q-----------------------SSPEA RW--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------PY VRPFSYVGIDYMGPLE-------------------------------------------- ----------------------------VT--IG-R-----R-KE-----KR-YVA---V -FTCLV--IRAVHLEVSYDLSSESC-----IMAIRRF-TRRR-GSPVQIFSDNGTNFVGA SRELQ-M-Q------IQR-IDL-E----------------------CA---GTFTDARTK ----WSFNPPSAPHMGGVWERMVRSVKEAMTM-LD--D---G-RKL----TDEIL----- --WTT-----LVEVEGLINSRP--------LTY------------M----PQ-------- -------------------------------------DL--------------------- ----------- >1372/1-551 ---PTKRDIVAFNATTYDPSGLLSPILVLLKRFITI-MW-EKD----------I------ -DWDQ-K-IPQ--DMWPLWKTVAAQFTEKV-----YSMP--RQL---------------- ---V-TNYDYDSI-QLAV-FSDASKY-HYA-TTAYLR--FGF-KNE------RFES-K-- LIFA---------------------------KSRV-RPSSGGSE---------------- --------------------------------YSIPRMELVALE-IGV-NSAVNIANE-- -L------H---IKI-KDV---NI---------FS------------------------- ------------------------------------EYYIPHRVV-------IKQ-ESLT TKL-RIVLDASSHMK-NQ---LSLNDCLYPGPSIL--QSILGILLRSR---LPKF--LMT ADIEKAFHAVMVQEK--FRDAMK-----F------IWLKN---P-EE----GFKESNI-A TYRFSRLPFGVTCSPFLLAVT-ILTY------------L-------DLDLD--D-FN-ER F-LEN--LYVDNV-MFTSN-S---EEDLMNCYTKSK-ST-CDKM-------HMNLR-EFM CNNG-VV-RAKIPEKDR--S---------------------------------------- AQTTG-----------------KL--LG-------------------------------- -----HQW---------------------------------------------------- ----------------------------------------------------------TM ESPFKHIGLDYIGPLP-------------------------------------------- ----------------------------FK-LGQ-RLG------------KV-WVL---L -LTCLV--TRAVHLEIVSDNTTVGF-----INGLKRF-IARR-GAPSSILSDNAPQFKLG YRMIN-K-------DLKT----------YVNQ-----------DPSLT---TFLARHEIK ----IKLITPMSPWQGGIYERLVGIVKNILLKVLG--K-----GHH----TFLEL----- --ETL-----LIETEGIVNSRP--------ITS------------N-------------- ----------------------KK--------DIE--D-------SPAIR---------- ----------- >1377/1-546 ---PTKRDILRVMMSVYDPLGLLSNYMVLLKLLFQE-IWRE-G----------V------ -SWDD-E-IGE--RQVEKWNNWLLLLPEAE---S-IRIP--RCY--H------------- -LSASKG-TQRTV-ELHT-FADASEL-GYA-AVCYFR--FTE--GE------QISC-S-- LVGA---------------------------KSRV-APL--K-F---------------- --------------------------------VSIPRLELQAAV-IGS-RLAKSIELG-- -H------S-IKI---SRR---YF---------WT------------------------- -----------------------------------RIWYLPMFPV-------YNPN-K-P NKI-RIVWDAAAT-I-RE---TSLNSVLMKGPDQL--TPLPFVLYRFR---EKRI--AIS GDIAEMFLRVQMNED--DQQCQR-----I------LWCEA---D-GT---------VG-- EYVVTVMTFGAKCSPSCAQFI-VREN------------A----ARF-RTEY--P-EAVEV I-EKG--HYVDDM-LASVD-T---EEEAIQLAKNVH-HI-HQQG-------GFTMR-NWI SNSR-LV-IQAL--GS---TEMT---EKSIDG-----------------------NND-T VL--E-----------------KV--LG-------------------------------- -----LWW---------------------------------------------------- ----------------------------------------------------------AY VRPFSYSGVDYFGPYQ-------------------------------------------- ----------------------------VV--VG-R-----R-LE-----KR-WGV---L -VTCLT--TRAIIIEIAHSLSTDSC-----IMALQNC-FARR-GTPIQIISDRGTNFVGA SKELK-D-------ALALVDSS-K----------------------LI---SEFTTPSTS ----WKFNPPVCPHMGGAWERMIQIIKKILMEIKP------K-RSP----TDEVL----- --RNM-----MIKVENIVNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >1379/1-576 ---ATRRGVLSVVASLYDPLGFVAPFLLVGKRVLQE-MCRH-G----------T------ -GWDD-A-LTD--ELRPRWERWKRDLINME---K-LSIP--RSY--A------------- -TADFGK--VTKQ-ELHH-FSDASTT-GYG-QCSYLR--MINE-EQ------EIHC-A-- LVMA---------------------------KSRV-APT--K-V---------------- --------------------------------TTIPRLELTAAV-ISV-KTSNVLREE-- -L------G-YTD---IEE---YF---------WT------------------------- ---------------E---------------GEKGEKWYIPHHGV-------YHAK-K-P DKL-RVVFDCSAK-Y-KG---TCLNDHLLTGPDLM--NNLNGILLRFR---LHST--ALM CDVEKMFHQFHVTES--DQDYLR-----F------LWWRK---GDLS---------TQPQ EYRMGVHIFGASSSPGCANYG-LKHL------------A----MQN-RNLY--PLGS-QF V-MRD--FYVDDG-VASVE-T---TKEAIQLAREAT-EL-CALG-------GLRLH-KFV SNNR-AV-LESI-------PPLERASDTENIN-----------------------LASDD -LPSG-----------------RA--LG-------------------------------- -----IQWHVNTD----------------------------------------------- ----------------------------------------------------------SV SPPFTYCGMDCFGPFY-------------------------------------------- ----------------------------TK--QG-R-----N-TR-----KR-YGL---L -FTCFS--SRAIHIEMLEDLSTDCF-----INGLRCF-IAIR-GMVRQITSDQGSNFLGA RNELK-E-------ALKEIDGD-K----------------------LT---TFLAENQCD ----FLMNAPGSSHAGGVWERQIRTVRSILNSTLS--L---SPGNL----NDASL----- --RTF-----LYEAMSIVNSRP--------LTV------------E-------------- ----------------------NL--------N----DPNSLEPLTPNHI---------- ----------- >138/1-561 ---FTKREVLSTIAKIYDPLGLVGPVVVIAKMMMQE-LWKM-K----------I------ -DWSE-P-LAN--QFNHRWRTYLTHLKDIW---L-VKVP--RRC--I------------- --SVQN-PV--QY-HLHG-FCDASLE-VYG-AAVYLR--SVDE-SG------TVSS-H-- LLGS---------------------------KSRV-API--N-R---------------- --------------------------------PPLQRLELCAAA-LLA-DLIKAIKST-- -I-R----I---P---IHQT--LG---------YS------------------------- ------------------------------DPNHSKIIYLAHHGV-------VKSE-STT TKL-RVVFNAAQKSS-NG---LSLNNLLATGPVVQ--DTLYNILINFR---LHAI--VLT GDIEKMYLQIRVTEE--DSKLIR-----L------LWQ-E---P-GQ---------PL-A EYGVNTVTFGMSCAPFLATRT-LNQL------------A----EDE-ESKF--P-LAKEA I--KD--FYVDDA-LTGAA-T---KEEAIEKRQQLT-DM-LKRG-------GFTIR-KWA SNDP-DV-LAEVPPEDRAVNP----VQAVD------------------------------ SQDTI-----------------KT--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------NQ APPFYICGVDYAGPIT-------------------------------------------- ----------------------------LVER--RTRG---TPST-----KG-YIA---I -FVCFV--TKAVHIEAVSKLSTRAF-----LAAMRRF-VARR-GHCAHMYSDNGTNFVGA DNEMR-H-------WYRKISTT-DH------------------NNRLA---DFLAMGGTQ ----WHFNPPGSPHMGGLWEAAVKSAKHHLNIVAH--N-----AKL----TFEEF----- --STL-----LTEIESILNSRP--------ISP------------A-------------- ----------------------SS--------DPN--D-------L-------------- ----------- >1381/1-575 ---PTKRQILQCVMTLFDPIGLLAPYLIFGRVLIQD-IWRA-G----------T------ -KWDE-Q-VDD--NIFQRWREWVKIWQDID---Q-VRIP--RSY--F------------- -RYPNRL-SVNNI-QLHI-FVDASPA-AYS-CACYFR--IIND-RG------EAEV-A-- LVAAKLPILAXQSHILWDFLYKWDCYASMGSKAKV-APL--K-M---------------- --------------------------------MSIFRLELQACV-LGV-RMMKLVIDG-- -H------T-FPI---KNR---FL---------WT------------------------- -------------------------------------WFLPLGVV-------VNPK-K-P SKI-RLIWDASAK-V-DG---VSLNSMLLKGPDQL--SSLPSVLFRFR---QHRV--AVV GDIKQMFHQILINHS--DRYAQC-----F------LWSPD---A-SK---------K-PD IFVMNVATFGSTSSPATAHFV-KNTN------------A----RRF-SKEF--P-RAVEG I-VYN--HYVDDY-LDSFP-D---EAEAKQVVEEVR-EI-HRRG-------GFEIR-NWC SNSS-AV-LEHL--GE-----NADNVVKKLNA-----------------------DFGGL PD---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PF TRPFTYVGVDYFGPIS-------------------------------------------- ----------------------------LK--RG-R-----Y-CV-----KR-WVA---L FFTCLT--VCAIHVEVVYSLTTEAF-----IMSVRRF-VGRR-GAPAEIYSDNATNFHGA ERILR-Q-Q----------INT-G----------------------LA---ATFTNTCTT ----WKFIPPGAPHMGGSWERMVRSMKSGLSVA-Y--C---D-EKL----DDEAY----- --QTL-----LVEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------LSTEQEALTPNHF---------- ----------- >1385/1-554 ---PTKREMLKLVMSLFDPLGFAAFYLIHGRVLIRD-AWAT-G----------I------ -GWDA-P-VNS--DLSERWLQWISMLPLLN---D-LQIP--RCY--F------------- -RGKIE----ETK-QLHI-FVDASDA-AYA-CVAYMR--ASG--SE------GIEL-A-- LVGA---------------------------KSKV-APL--K-V---------------- --------------------------------LSVPRLELMAAV-IGA-RMAESIVSS-- -H------S-FNI---ADI---YF---------WS------------------------- -------------------------------------WYLPLCVV-------VNPK-K-P NKV-RVVWDAAAK-V-NG---VSFNSALLKGPDML--TCLVSVLYHFR---EHRI--AVT GDIEEMFLRLLIRPQ--DSQYQR-----F------LWMAN---A-GD---------A-PS VYIIDVAIFGSTCSPSSAQFV-KNAN------------A----REY-MEEF--P-RASTA I-IKY--HYVDDY-LDSFD-T---VQEAIKVVKQVK-MV-HSQG-------GFNLR-NFL SNSN-EV-LAAI--SDT----TIED-TKQLNL-----------------------V-RAE KV--E-----------------SV--LG-------------------------------- -----MKWNPSKDVFVYTV----------------------------------------- ----------------------------------------------------------PF VRPFTFVGLDYFGPLT-------------------------------------------- ----------------------------VK--VG-R-----S-EV-----KR-WVA---L -FTCLT--VRAIHLEVVHSLSSESC-----VMAIRRF-IARR-GAPAEIFSDNGTNLVGA NKQLR-Q-E------IAA-RDQ-V----------------------LA---STFTNTNTR ----WNFNPPGAPHMGGAWERLVRSVKSAIGTIVD--A---P-RRP----NEEAL----- --QTI-----LFDAEAMINSRP--------LTY------------V-------------- ----------------------PL-------------ET--------------------- ----------- >1389/1-542 ---NTKRQMISDASKLFDPFGWLAPVIVKIKILYQH-LWLY-D----------V------ -NWDD-P-LPT--AIESEWVNLKQNLSQLE---T-IRIP--R-F--V------------- -AHNRGK--I----QLHG-FSDASEQ-AYA-AVVYSR--SVDD-TG------NITV-V-- LIAA---------------------------KSRV-API--K-Q---------------- --------------------------------VSLPRLELNGAL-LLT-ELMKKVTEA-- -M------P-HRE---IEH---FA---------WT------------------------- ---------------------------------------LPHHAV-------VKVD-SST TKM-RVVFDASCATS-TG---VSLNDRLLPGPNIN--NDLLSVLLRFR---SYKV--AFS ADIAKMYRQVVVSED--DRDFQR-----I------VWREN---T-EQ---------PI-Q HYRLSTVTYGTKTAPYLAIRA-MRES------------A----KDY-ISSH--P-AAVER I-VYD--FYVDDL-LSGAD-D---EEEATTIKEQIS-DI-LSKS-------GFELR-KWA SSCP-SL-LQ---NESPVAVPMKL-SDEAD------------------------------ ---AV-----------------KA--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------LA TRAFAFVGIDYAGPLK-------------------------------------------- ----------------------------IKAS--CIRG---VKIS-----KG-YIV---V -YVCQS--TRAIHLEAASDMTTNTF-----LSTLKRF-VSRR-GYPNEIRSDNGTNFIGA DRVLR-E-------FMEQIHAN-CK--------------------DAG---RYLANRGIR ----WVFNPPSAPHMGGIWEAAVKSVKHHLVAELG--T-----EAT----TFEDL----- --TTI-----LCQIEACLNSRP--------LCP------------L-------------- ----------------------SS------------------------------------ ----------- >139/1-560 ---PTKREVLRTVMSFFDPLGLISFYLVHGRILMQD-IWAI-G----------I------ -GWDD-P-INE--KICMQWKKWIDLIPELS---N-LRIP--RCY--I------------- -RGATES-SYSEL-QVHV-FVDASQS-AYA-AAAYFR--AET--PE------GPVV-N-- LVAA---------------------------KSKV-APL--K-L---------------- --------------------------------LTIPRLELQAAV-LGS-RLLNSVIAM-- -H------A-LPV---TKR---VL---------WS------------------------- -------------------------------------WYLPLGIV-------LNPK-K-P NKL-RMIWDAAAT-V-DG---VSLNTALLKGPDFL--TSLPAVIGKFR---LYRY--ALT GDIKEMFHRFFIRAQ--DRQFQR-----F------LFRDH---P-HE---------E-PV IYVMDVAIFGSACSPSSAQYI-KNLN------------A----REF-EAEY--P-RAAAA I-IHR--HYVDDY-LDSFG-T---VEEAVKIGRQVK-NI-HAEG-------GFEIR-NFL SNDP-TI-AAHV--GD-----ESSEAEKHIHV-----------------------E-KNE RI--E-----------------SV--LG-------------------------------- -----MKWIPSSDTFTFTISLR-------------------------------------- ----------------------------------------------------------PY VRPFTFVGVDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NV-----KR-WIA---L -FTCLT--IRAVHLEVVHSLSKESC-----VMAVRRF-VSRR-GAPAEIFSDNGTNFLGA NNQLK-R-E------IEE-LDQ-H----------------------LA---STFTNTTTR ----WSFNPPGAPHMGGAWERMVRSVKVAIGGLLE--T---Q-RRP----DDETL----- --ETI-----IIEAEAMINSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >1390/1-554 ---PTKREMLKLVMSLFDPLGFAAFYLIHGRVLIQD-AWAT-G----------I------ -GWDA-P-VNS--DLSERWLQWISLLPLLN---D-LQIP--RCY--F------------- -RGKIE----ETK-QLHI-FVDASDA-AYA-CVAYMR--ASG--SE------GIEL-A-- LVGA---------------------------KSKV-APL--K-V---------------- --------------------------------LSVPRLELMAAV-IGA-RMAESIVSS-- -H------S-FNI---ADI---YF---------WS------------------------- -------------------------------------WYLPLCVV-------VNPK-K-P NKV-RVVWDAAAK-V-NG---VSFNSALLKGPDML--TCLVSVLYHFR---EHRI--AVT GDIEEMFLRLLIRPQ--DSQYQR-----F------LWRAN---A-GD---------A-PS VYIIDVATFGSTCSPSSAQFV-KNAN------------A----REY-MEEF--P-RASTA I-IKY--HYVDDY-LDSFE-T---VQEAIEVVKQVK-MV-HSQG-------GFNLR-NFL SNSN-EV-LAAI--SDT----TIED-TKQLNL-----------------------V-RAE KV--E-----------------SV--LG-------------------------------- -----MKWNPSKDVFVYTV----------------------------------------- ----------------------------------------------------------PF VRPFTFVGLDYFGPLT-------------------------------------------- ----------------------------VK--VG-R-----S-EV-----KR-WVA---L -FTCLT--VRAIHLEVVHSLSSESC-----VMAIRRF-IARR-GAPAEIFSDNGTNFVGA NKQLR-Q-E------IAA-RDQ-V----------------------LA---STFTNTNTR ----WNFNPPGAPHMGGAWERLVRSVKSAIGTIVD--A---P-RRP----NEEAL----- --QTI-----LFDAEAMINSRP--------LTY------------V-------------- ----------------------PL-------------ET--------------------- ----------- >1395/1-550 ----TKRAVMSDVARIYDPLGFLDPIKMTAKLLLQR-IWAM-K----------N-NSGKN WSWDE-L-LPE--AMQIEWKAFVNQLNRLE---Q-IRIP--RRL---------------- --LMDG-----EW-QYHI-FCDASER-GYG-ATVYVR--NAEA-RR------GIEV-E-- LLMS---------------------------KSKV-ASL--S-K--R------------- --------------------------------LTIARLELCGAL-LAS-RLYQTMRRA-- -NMA--------K---GVC---YL---------WT------------------------- -----------------------------------AFYYMPHHAV-------WKPG-STT TKC-RVVFDASCKTG-SG---HSLNDILMIGPQLQ--DDILLILLRFR---MRAV--AMI ADVEKMYRQILIKEE--DRKLQR-----I------LWREN---E-NE---------PV-K VYELQTVTYGTACAPYLAIRT-LRKV------------F----EDH-ENEF--P-KAQE- W-RDD--FYVDDL-ISGAN-N---VEQAKEIAKQVS-VM-LSKA-------GFKLR-KWA SNAL-EA-LDHVP-EDDCAQSD---EFNVD------------------------------ -NEDV------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------TE ARPFAISGVDYCGPFY-------------------------------------------- ----------------------------VKSN--QRKS---VPT------KA-FVA---V -FVCFV--TRAIHLELVSDLSTSAF-----LAAFRRF-VARR-GLVTEMNSDNGTNFKGA ANELR-K-------LHDLFKSV-QF------------------QESVQ---SWSSQQGIK ----WKFIPPRAPHFGGLWEAAVRSMKFHLRRVIG--D-----SPM----TYEHL----- --LTV-----LVEIEGCLNSRP--------LTS------------L-------------- ----------------------SD--------DPA--D-------M-------------- ----------- >1396/1-541 ---MTWRGILSIVASLYDPLGFVAPVVLDGKRILQE-MCRS-G----------L------ -GWDD-P-VPE--NLQSRWEQWCKEIPQLE---E-LRIP--RCY--H------------- -PAEFGD--PVTV-QLHH-FSDASKS-GYG-QCSYLR--LVNQ-KG------EVHC-C-- LIFG---------------------------KSRV-APT--K-V---------------- --------------------------------VTIPRLELTAAV-VSA-KVHSMLKEE-- -L------E-YHD---AED---FF---------WT------------------------- -------------------------------------NYIPHHGV-------YHPM-K-- KKM-RIVFDCSAK-Y-GG---TCLNDHLLKGPDMI--NSLVGVLCRFR---KHNV--AVL CDVEKMFFQFRVAED--DRDLLR-----F------LWFQD---NDIN---------KEPV DYRMNVHLFGAASSPGCANYG-LKYL------------A----RHC-SNEF--PLAS-RF V-ERS--FYVDDG-LVSVS-S---EEEAIQLANEAR-QL-CSKG-------GLRLH-KFV SNSK-AV-LESL-------PKSERASDVTDSN-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SAPFTNVGMDCFGPFF-------------------------------------------- ----------------------------VR--RG-R-----S-DI-----KRIWAY---I -HMSLF--KR-YHIEMLDDMTTDAF-----INALRCF-IAIR-GAVRQIRCDQGSNFVGA RNELQ-S-------ALREMTSD-Q----------------------VN---TYLADQQCE ----FVFNAPHSSHAGGVWERLIRTVRSVLRATID--L---CPGRL----TDSAL----- --RTL-----FYEAMAIVNSRP--------LTV------------T-------------- ----------------------NM--------N----DPSA-------DA---------- ----------- >1397/1-529 ----TMRNIYRTLASQYDPLGYLIPYTTRAKLIVQR-LWDK-K----------R------ -DWDD-SNLPP--DLLHTWKEWEAELPSLL---H-IRLP--RSY--T------------- -SLAKDK-ETSKR-DIHV-FCDASER-AYG-SVAYLR--TEDQ-QG------DVEV-S-- FLTA---------------------------RSKV-APK--K-Q---------------- --------------------------------QSIPRLELCAAL-TGA-QLAKVVTTE-- -L------T-LPI---HHI---TL---------WT------------------------- -----------------------------------QAWYIPHHMV-------HHN----- GKN-RVVFNCSFN-Y-QG---QNLNDLLLPGPVLG--PSLLAVLLRFR---EHSI--AVS SDIRGMFHQIRLLPE--DRPLLR-----F------LW-RD---LKAQ---------EPPR VFEWQVLPFGTTCSPCCAVYA-LQKH------------V----LDN-SEP---EDDIRHS V-MKS--FYVDNC-LQSFT-T---TEEAQSFVNKIQ-TL-LADG-------GFELR-QWS SNQP-LT-ISHL-------PSE-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------L ----------------------------------------------------------LF KPAFYSTGMDCFGPYA-------------------------------------------- ----------------------------VK--AG-R-----R-TE-----KK-WGI---I -FKCLT--TRAVHIDVLHTLDADSF-----LMALRRF-TARR-GTPFELISDQGTNFRGG ERELR-E-------AFAALAPE------------------------LQ---AQLAKQQIK ----FRFNPPNAPHFGGCWEREIRSLKQALTVTIG--A---Q--SV----TFEVL----- --QTV-----LVEIEGILNSKP--------LGL------YFLXHCR-------------- ----------------------PX-------------SR--------------------- ----------- >1399/1-565 ---TTKRLILSTVARIFDPLGLISPVIVEAKLLIQD-IW-AKG----------L------ -DWDQ-P-VQG--KLLQRWIEIRSSLRQVS---E-ISFP--RLV--N------------- --STNAVRR-----ELHG-FADASKR-AYG-ASVYLR--CVNP-DG------SVTM-H-- LLCS---------------------------KSRN-APT--P-E---------------- --------------------------------ITIPKLELCAAK-LLA-ELMVKVIEA-- -VK-------MDF---DDI---VL---------WS------------------------- -----------------------------------KAYYMPHHAV-------LRPS-STS TKL-RVVFDASAKSS-SG---TSLNDLLMVGPPVQ--DSLFAILLRFR---LCPY--VFS ADLSKMYRQIRIDPD--HSSFQR-----I------FWREK---P-GD---------PL-K VFGLSTVTYGTASAPFLATRT-LVQL------------A----EDE-QKEF--P-IGAKL L-KES--FYVDDC-LCGFE-T---LEEAAQAIDELR-GI-LSKG-------GFPIH-KWC SNSQ-QL-LDLVPKDEWEKRA------EIL---------------------------HSS VNQTV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------VP SAPFESTGVDFAGPVY-------------------------------------------- ----------------------------IK--YGIRRP---AVV------KA-YIS---V -FICMT--TRAIHLELVSDLTSEAF-----LAALRRF-TCRR-GYPRQMLSDNGLNFVGA NKDLK-E-------LVRLFKEK-QT------------------LKEIN---EFCEPREIE ----WNFIPPRAPNFGGYWEAGVKSVKTHLKRVLG--K-----TPL----SFEEY----- --ATV-----LTQVEAILNSRP--------LFA------------H-------------- ----------------------SS--------DPT--E-------PTAITPGHF------ ----------- >14/1-558 ---ATKRNILSVTSKLFDPLGLLSPIVIKGKILLQE-LWLN-K----------L------ -DWDE-S-IPL--HLETAWNKLKNTLSQLE---D-ISIS--RFV--Y------------- --SD-P-MS--PV-QIHA-FADASMR-AYG-ACVYIR--SRTA-EG------LKI--S-- LLTS---------------------------KSKV-APL-------K------------- ---T----------------------------KTLPRLELCAAH-LLA-DLCHRIKPL-- -L-N----V-P-I---ERV---VY---------WS------------------------- ------------------------------TIPSTPHYVIPHQCV-------LRPQ-STS TKL-RVVFDASSKTS-SQ---VALNDILMVGPTIQ--EELYSTLLRFR---LHRF--ALT ADVKKMYRQVMVNEA--DRQFQL-----I------VWRRD---P-SE---------SL-R LYKLNTVTYGTGPAPFLAIRC-LKRL------------S----ESA-KLSF--P-RAANV I-GSD--FYVDDL-LTGAA-C---VEELRAIKSEVS-QV-LQTA-------GFELT-KWF SNSP-EI-TASESTAKPITIS--------------------------------------- DSEST-----------------KA--LG-------------------------------- -----ISWLPTDD----------------------------------------------- ----------------------------------------------------------RA LRPFSICGVDFCGPVH-------------------------------------------- ----------------------------TTLK--IRGR---PPY------KS-YIA---L -FVCFA--SKAVHLEIVSDLTTDCF-----LLAFQRF-VGRR-GYPQVVHCDNGTNFVGA SRHLS-A-------LRIRLKEQ-G--------------------DAIR---DFASKNGCE ----FAFIPPRAPHMGGLWEAGVKTAKSLLLRAVG--S-----ALL----TAEEL----- --ATV-----LVGIEAIMNSRP--------LGA------------I-------------- ----------------------SQ--------DPS--D-------G-------------- ----------- >140/1-570 ----TKRIALSEMSRLFDPMGLVGSVIVSAKIFLQS-LWSN-S----------F------ -SWDS-V-LPQ--DYQNWWKFFREELQTLS---T-LKIP--RRV--L------------- --ID----HYVHV-EMHC-FADASDK-AYG-CCLYIK--SIDR-SG------NSAC-N-- LLIS---------------------------KSKV-SPL-------T------------- ---K----------------------------QSTPRLELCAAV-MAA-QLADSVKKA-- -T-E----L-A-----CST---TF---------WS------------------------- ------------------------------PDLSTPHFFLPHHAI-------LRPD-STT TKT-RVVFDGSCRSA-NN---LSLNDICYVGPTVQ--PPLLATSLNFR---MTKY--AIT ADAEKMYRQIWVHCS--DRALQQ-----I------VWRKY---R-SE---------EL-K TYQLNTVTYGTACAPYLATRV-LNQL------------A----DDE-KERF--P-LAARL V-KRC--FYVDDC-LAGDD-D---KQRMMESCDQLI-EL-LASG-------GFVLR-KWS SNDA-EI-LSHIPEHLRDNRD------DLE----------------------------ID KSNSV-----------------KT--LG-------------------------------- -----LLWHPQIDCFGFKV----------------------------------------- ----------------------------------------------------------TP SRAFVKSGVDYCGPFF-------------------------------------------- ----------------------------VRPP--NRRG---NSV------KI-FVA---I -FVCMA--SKAVHIDMVYSLSSDSF-----VSALKRF-TSRR-GHVTDVYCDNARTFVGA NRQLQ-E-------HKQQFDDV-HR------------------SDALA---QSCTEAGIN ----FHFNPARSPHFGGLWEAAVKTFKHHLYRIMK--T-----TLL----TIEEF----- --QTL-----ITQIEGIMNSRP--------LTP------------L-------------- ----------------------TS--------DPA--D-------V-------------- ----------- >1400/1-557 ---PTKRETLRMLMLMYDPCGFIAHFLMYLKVLLQE-IWRS-G----------I------ -SWND-K-IED--KEFEKWLLWIKVLSKVQ---D-VEIK--RCF--R------------- -DQTSVD---ADI-QLHT-FVDASEN-GFA-AVVYLR--FRE--ES------RIEC-A-- LVAA---------------------------KTRV-APL--R-F---------------- --------------------------------LSIPRAELQAAI-LGV-RLANTVQRS-- -L------N-IKV---SQR---FF---------HT------------------------- -----------------------------------RVWYLPVFPV-------MNPN-K-P TKT-RLVWDASAK-A-HD---VSLNSVLLKGPDYL--TSLLSVLIQFR---EHRI--AVC GDLREMYHQVLIREE--DQHCQR-----F------FWGHK---E-NS---------AEPN VYIMQVMTFGACCSPSAAQYV-KNKH------------A----KLY-DKTR--P-AAVRA I-IEH--HYVDDM-LVSVE-T---EEEAVSIAQDVK-WI-HEKA-------GFEMR-NWL SNSP-AV-LAQL--EE---HQVM---EKDLNV-----------------------SDG-I VT--E-----------------KI--LG-------------------------------- -----MWWNTEKDYFTFKL----------------------------------------- ----------------------------------------------------------AY TRPFTHTGVDYFGPIT-------------------------------------------- ----------------------------VS--IG-R-----R-TE-----KR-WGV---I -ATCLT--TRAIHLQVAYSLSTDSC-----IMALRNI-FNRR-GTPAVIYSDRGTNFQGA TKVLE-E-------AVRNIDQN-R----------------------VV---AEFTSKHTE ----WRFNPPASPHMGGAWERLIRSVKQNLSKVMA------S-RTV----TPEVL----- --ENA-----LNEVENIVNSRP--------LTA------------I-------------- ----------------------PV-------------DD--------------------- ----------- >1401/1-534 ---PTKREMLRTLMAIFDPLGLISNLLIFLKILLQE-VWRS-R----------V------ -GWDD-Q-IPD--ELKDKWELWLRYFPAVH---S-VSIP--RCY--R------------- -AMVRLE-DDTNV-QFHT-FVDASEL-GYA-TVIYLR--FEQ--QG------KVEC-M-- IVSA---------------------------KARV-APL--Q-F---------------- --------------------------------VSIPRLELQAAV-IGS-RLAETIVNS-- -L------S-FKV---NQR---FY---------WT------------------------- -----------------------------------QIWYLPIFPV-------FNLN-K-P GKL-RIVWDAAAK-S-QG---ISLNMMLLKGPDQL--TSLNSVLYKFR---ENKV--AIC GDIKEMFHQTVIKEE--DQNCQR-----F------LWREH---P-ND---------LEPS TFVMQVMTFGACCSPSCAQYA-KNVN------------A----REH-EEEY--P-DAAEA I-IKK--HYVDDM-LASVE-T---EDEAIKFAQDVR-HV-HAKA-------GYEMR-NWL SNSS-TV-LNSL--NE---GKEC---EKNLNL-----------------------TS--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF TRPFSFIGVDYFGPLY-------------------------------------------- ----------------------------VT--VG-R-----R-LE-----KR-WGV---L -VTCLT--VRAIHVEIAHSLNADSC-----IMALRNF-MARR-GVPIRIFSDRGTNFVAS SKELE-A-------ALREMDQD-K----------------------VI---HEIVSPDTE ----WEFLPPASPHMGGCWERLVRSVKVNLQKMKP------Q-RNH----SDESL----- --RNT-----LTEIENIINSRP--------LTF------------V-------------- ----------------------SV------------------------------------ ----------- >1402/1-526 ----TKRLVLSRLASLFDPLGLIGPAIVKAKIFMQA-LWKH-Q----------V------ -DWDT-P-LPS--ALQLEWHEYQLQIININ---Q-VSVP--RYV--L------------- --PLQK-VV--LC-ELHG-FSDASES-AYG-ACLYIR--SITA-DG------FCTV-R-- LISA---------------------------KSRV-API--D-N---------------- --------------------------------KSIPRLELCAAL-LLA-HLLEKFLES-- -V-E----I---R---ATV---YL---------WS------------------------- -------------------------------------YFLPHHAV-------LKPE-STT TKL-RTVFDASCKSK-SG---LSLNDVLLAGPTVQ--DTLVAIVFRFR---MHAF--VAV ADISKMYRQILVDDG--DQPLQR-----I------LFRFS---T-EE---------PI-K VYQLLTVTYGTNCAPFLATRV-LQKL------------A----DDE-EKRF--P-EAAPI V-RKS--FYVDDM-LTGSS-S---VQRLRRIIEQVN-GM-VESA-------GFSLR-KWA SNCH-EA-LVD------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TG NFVFGNVGIDFAGPMY-------------------------------------------- ----------------------------LKSG--ARFT---QPV------KG-YIA---I -FVCLA--TKAAHLELVMSLTTSAF-----LAALKRF-ISRR-GRPANIYCDNAKNFRGA STQLE-S-------LRKLFISQ-NH------------------KKEIN---SFCEPNSIH ----FHFIPPRSPSFGGLWEACVKSTKFHLRRIVG--K-----AQL----NKEQF----- --ETV-----LAEVEACLNSRP--------ITP------------L-------------- ----------------------ST--------DPS--D-------L-------------- ----------- >1403/1-541 ---MTRRGILSIVASLYDPLGFVAPVVLDGKRILQE-MCRS-G----------L------ -GWDD-P-VPE--NLQSRWEQWCKEIPQLE---E-LRIP--RCY--H------------- -PAEFGD--PVTV-QLHH-FSDASKS-GYG-QCSYLH--LVNQ-KG------EVHC-C-- LIFG---------------------------KSRV-APT--K-V---------------- --------------------------------VTIPRLELTAAV-VSA-KAHSMLKEE-- -L------E-YHD---AED---FF---------WT------------------------- -------------------------------------NYIPHHGV-------YHPM-K-- KKM-RIVFDCSAK-Y-GG---TCLNDHLLKGPDMI--NSLVGVLCRFR---KHNV--AVL CDVEKMFFQFRVAED--DRDLLR-----F------LWFQD---NDIN---------KEPV DYRMNVHLFGAASSPGCANYG-LKYL------------A----RHC-SNEF--PLAS-RF V-ERS--FYVDDG-LVSVS-S---EEEAIQLANEAR-QL-CSKG-------GLRLH-KFV SNSK-AV-LESL-------PKSERASDVTDSN-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SAPFTNVGMDCFGPFF-------------------------------------------- ----------------------------VR--RG-R-----S-DI-----KR-YGL---I -FTCLC--SRGIHIEMLDDMTTDAF-----INALRCF-IAIR-GAVRQIRCDQGSNFVGA RNELQ-S-------ALREMTSD-Q----------------------VN---TYLADQQCE ----FVFNAPHSSHAGGVWERQIRTVRSVLRATID--L---CPGRL----TDSAL----- --RTL-----FYEAMAIVNSRP--------LTV------------T-------------- ----------------------NM--------N----DPSA-------DA---------- ----------- >1408/1-549 ---PTKRQVLQTIMKLFDPLGLISHFIVHGKILMQE-IWRS-G----------T------ -NWDE-P-IAE--HLLDQWHRWIELLGLLS---E-VKVP--RCF--F------------- -KGQPSD-SLQGL-QLHV-LVDASEV-SYA-CVAYLR--LNT--TY------GGRC-V-- LVAS---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAL-IGA-RLSQGIKSA-- -L------T-LSI---GKC---YY---------WS------------------------- -------------------------------------WYLPLGVV-------TNEK-K-P DKI-RLIWDAAAK-V-GG---VSFNDFLLKGPDLL--TSLHDVLLRFR---ERSV--AIC GDICEMFHQIRIREP--DKQSQR-----F------LWRNS---S-VE---------P-IQ TYVMDVSTFGATCSPCSAQFI-KNKN------------A----REF-SEVY--P-RAVNA I-IYN--HYVDDF-LDCTD-T---EEEAIELVQNVK-AI-HATA-------GFEIS-KFR SNSA-EV-LSAL--GE-----HYGGQNKLLCS-----------------------D-KQA TS--E-----------------RV--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------PF IRAFTYVGVDYFGPLE-------------------------------------------- ----------------------------VK--VG-R-----G-VA-----KR-WVA---L -FTCLT--VRAVHLELTHSLSTQSC-----IMAIRRF-VARR-GAPREVYTDNGTNFHGA GRRLN-E-EKQ---MLQK-LSE-R----------------------CA---TTFTNANTT ----WYYNVPAAPHMGGPWERMVRAVKTAMKAISE--Y---P-RHT----NDEVL----- --ETV-----LLEAESVVNSRP--------LTY------------V-------------- ----------------------PV-------------EG--------------------- ----------- >1409/1-524 ----TLRNIYKVLARQYDPLGFILPYTTRAKLIVQR-MWDK-P----------R------ -DWDD-PHIPQ--DLQEAWKEWESELHLLP---H-ISFP--RPY--A------------- -STPHSQ-MIVSR-QIHV-FSDASEK-AYG-AVSYLR--TEDS-QG------QVSL-A-- FLAA---------------------------RSRV-APR--R-Q---------------- --------------------------------HSIPRLELCGAL-TAA-QLAKTIARE-- -L------T-VAI---DQT---IL---------WS------------------------- ----------------------------------EESWYIPHHLV-------SHN----- GKN-RLVFNCSYQ-H-QG---QNLNDTLLPGPTLG--ASLLGVLLRFR---QHAV--AVS GDIKSMFHQVQLLPR--DRPLLR-----F------IW-RD---MRRM---------EPPD IYEWQVLPFGTACSPCCATFA-LQLH------------A----RTH-SKE---GDGVRHS V-EQC--FYVDNC-LQSVD-T---ADEARKLVDQIR-EV-LASG-------GFEIR-QWA CNLP-DV-IKHL-------PAEA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LH KPAFYSTGVDCFGPFQ-------------------------------------------- ----------------------------IR--IG-R-----R-SE-----KR-WGI---I -YKCLT--TRAVHLDLLHNMDTDSF-----LMSLRRF-IARR-GTPAELLSDQGTNFKGG EKELR-D-------SFNSMSLD------------------------LQ---QLLAKQKID ----FRFNPPAAPHFGGTWEREIKSVKSALHTVMG--V---Q--SV----SEEVL----- --YTV-----LLEVEAILNTKP--------LGY------------T-------------- ----------------------SS-------------SV--------------------- ----------- >1414/1-532 ----TEGTLVSYVAKVSDVMGWFSPTIIKAKILLQH-LWEA-K----------F------ -KWVD-L-VPS--CVLDTWIRXKSELPLLA---X-IYIQ--K-Y--Y------------- -FTDSER--LISL-QLHG-FSDASED-AYA-AVVYLR--CVEV-ND------HIHV-S-- IALS---------------------------KSRV-APM--K-R---------------- --------------------------------LTIPCLELCGAQ-LLT-QLLHHTHGC-- -L------I-NXI--------------------WY------------------------- -------------------------------------FYCPIHVV-------YKE-SSTT TKM-RPVFDASAKSE-TG---ISLNDTLFVGPTVH--PTLVDVLLRFR---LHRI--ALT TDVTKMYRAIQLADI--DKDLHR-----Y------VWHSN---P-ED---------TL-S DYRITCVTFGISDSSFAANVT-LKQN------------A-----IDWAHKY--P-LAAKA V-KQS--FYIDDD-LTGAD-T---VYEAISLHYELQ-QL-ISCG-------EFHLR-KWN SSHS-TV-QLQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP DSMFENVGVDYAGPIQ-------------------------------------------- ----------------------------IKYG--YLRK---PTLV-----KT-YVC---V -FISLS--VKAIHLELVSDLNTEAF-----LTCLRWF-ISCH-SHPKLIWSDHSTNIVGA DNELK-Y-------LLIFXEQE-XT------------------QRQIS---XFCTSRKIE ----XKFVPQHSPHFEGLXKAAVKSMKRILKKVIG--N-----VIL----TFEEF----- --CTV-----LAEIEACLNSRP--------LTP------------L-------------- ----------------------MS--------NDD--G-------IEVLTPEQF------ ----------- >142/1-554 ----TKRVVCSELSQIFDPLGLFAPVVVKAKIFMQH-LWES-K----------M------ -AWDD-E-LPL--ELQSDWKTYRSDLQSLN---K-LQIP--RHI--F------------- --DGKV-PV--TQ-ELHT-FVDASEK-AYG-AAIYVR--ATYK-NK------QTSV-R-- LLCS---------------------------KSRV-APT--A-K---------------- --------------------------------QSLPRLELCAAV-LGA-ELTHRVRQD-- -L-R----L---S---LDTVAGFF---------WT------------------------- -----------------------------------NHYFIPHHCV-------LKPD-SSS TKL-RVVFDASCKTS-SG---KSLNDILHTGPTVQ--SELMAILLRFR---IHKY--VFT ADIEKMYRQVWINPD--NQFHQL-----I------VWRND---P-SE---------DL-K YYRLKTVTYGTKTAPFLATKC-LNHL------------A----IRS-RDNY--P-LGSAA L-END--FYVDDC-LTGAD-S---VAEAVQIQSELN-KI-LLPH-------GFKLR-KWC SNNA-EL-LQGIPKEDTVSDVKLG-ET-LD------------------------------ -QYSV-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------TQ ARPFFNSGVDYCGPIW-------------------------------------------- ----------------------------IHHK--IRGK---RPD------KA-YIA---V -FCCFA--TKAIHLELVSDLTTDAF-----LAALRRF-LGRR-GKCQTIHCDNATNFIGA NNKLK-E-------LETSIFST-NA------------------QDSIV---QHCNKREIN ----FKFIPPRAPSFGGLWEAAVKSAKRLLVSITA--T-----ASL----TFEEL----- --NTV-----VVEVEAILNSRP--------ITP------------M-------------- ----------------------SS------------------------------------ ----------- >1423/1-556 ---ATRRGLLSVVSSVYDPLGFASPFILPAKVLLQD-LCRN-D----------Y------ -GWDD-E-ITG--DYLVRWNKWLDELKTLN---G-LRVS--RCH--K------------- -PADFGK--VVDA-QLHH-FADVSEL-GYG-AVSYLR--QTNA-EG------KVHC-S-- IVIG---------------------------KSHM-APV--K-K---------------- --------------------------------MTIPRLELPAAT-VAV-RLDKMCRRE-- -L------D-VRI---SGS---FF---------WT------------------------- ---------------Q---------------RNDGKLWFIPHHFV-------TSQH-K-P DKP-RLVFDCAAK-Y-RG---TSLNEQVLRGPDFT--NKLVGVLMRFR---EEPV--AMM SDIEAMYNQVRVTPD--DRDALR-----F------LWFPD---NNFD---------RPPE DNRMATHLFGWIWSPNCANYA-LLKT------------A----DDN-AREF--DEETVKT V-RNN--FYVDDC-LRSVD-S---IEKAVLLSDELT-RL-LTKG-------GFNLT-KWV SNRR-EV-LEKI-------PSDARAKNVKNLD-----------------------LHA-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PD SPPFSYVGVDCFGPFM-------------------------------------------- ----------------------------IK--RS-R-----S-EV-----KR-YGV---M -FTCLT--TRAVHLEVTHHMDTPSF-----INSLRRF-IARR-GAPQEMRSDNGTNFTGA EKELR-E-------AIADWNQQ-D----------------------IQ---DYLMQQEVR ----WVFNPPAASHMGGVWERPIRTVRKVLRALLK--Q---Q--HX----DEEGL----- --TTL-----FCEVEAIVNGCL--------LTT------------I-------------- ----------------------SD-------------DTKDAEALTPNHL---------- ----------- >1424/1-544 ----TKRGVLRVLMSLFDPHGLISNFLIHGKIIIQD-LWRS-G----------V------ -SWDE-P-IPR--KIQEQWERWINLLQNLS---R-IRVP--RCY--F------------- -PGYHVE-DLKTL-ELHV-FVDASES-AYA-CVAYFR--IIQ--DG------KPRC-V-- FVTS---------------------------KAKV-TPL--K-S---------------- --------------------------------VSVPRLELNAGV-IGC-RLAKTIKEN-- -T------T-LPI---SRT---VY---------WT------------------------- -------------------------------------WYLPLGVI-------TNPK-K-P EKV-RIIWDAAAK-V-NG---VSFNSMLLKGPDML--TSLSSVLFRFR---ERKF--CIT ADIKEMYHQVKIRPE--DRLSQR-----F------LYRSD---P-SH---------Q-PD TYVMDVATFGSTCSPCSAQFV-KNLN------------A----ERW-RESY--P-EAAEA I-VQN--HYVDDY-LDSRD-T---EEEIIKLSEDIR-TV-HSKA-------GFEIR-NWR SNSH-EV-LRRV--GA-EPAN----VEKMLFV-----------------------D-KAV PA--E-----------------RV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PH ERAFTRVGIDYCGPFA-------------------------------------------- ----------------------------VR--FG-R-----G-TV-----KR-WVA---L -FTCLA--TRAVHLEVVASLSTESC-----KLALRRF-INRR-GAPAEIYTDNGTNFQGT QRELL-E-Q------VQD-TNR-S----------------------LA---ETFTDANTS ----WFFIPPATPHMGGAWERMVRSVKAAMNG-LQ--K---T-RTP----TEEVF----- --QTI-----CTEAESMINSRP--------LTY------------M-------------- ----------------------PL-------------ET--------------------- ----------- >1426/1-550 ---WTKRQVLASIAECFDPCGIISPTLLKGKWLMQK-LWE-SK----------M------ -TWDN-P-LNE--ELKIEWELIKDEYLSCN---T-IQVT--RRL--I------------- ----SWKMTKPTV-YELCAFSDASDK-ALG-FAVYLR--SQNGRE--------IQT-A-- LIFA---------------------------KSRV-KPK--AQLGKCETK---------- --------------------------------MTIPRMELHAAL-IAT-KALDYLEEM-- -L------E-IKIA---KK---ML---------WT------------------------- ------------------------------------------------------ED-KTF TKF-RIVFNASGKSRKDN---PSLNDCLHQGPVTI--QDLCGLLMRSR---FPTY--LIA GDLQAAFLQISLRPP--DRDSVR-----F------LWVSDIKKP-SE----AQTD-EDLR IFRYARVTFGVNCSPSILGMTVDHHL------------S--------KYDS--TTA--EK L-KKA--GYVDNF-LIGAE-E---NAEVEKDILEAR-KI-FQDA-------GWNFR-EIF TNAS-KQ-LNDIPFEKLPIEARTSNLCSGAKQ---------------------------- ----------------------KI--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------NQ FRPFMYSSVDYFGPMT-------------------------------------------- ----------------------------IKLK-NAEHI------------KR-WVA---V -YTCTS--TRAVHLEIAEDLSAQAF-----LKTFRRF-IAHR-KKPVLMISDNGTNFKAA EKILK-S--------------I-FK---ET---------------QIQ---KFASDHEIK ----WIFVTERAPWKNGLVERMVGLIKYSLRRTVG--R-----RLL----EEEEF----- --RTL-----ITEVQTVVNSRP--------LNF------------I-------------- ----------------------PD--------S-E--Q-------V-------------- ----------- >1427/1-600 -----RRTVSSTIAGVYDPLGILAPLMLQMKLFQRL-LWSE-E----------------- YEWDT-E-LNS--EHDQQCTKLMETQNDFK-----CEFP--RHI--I------------- -EKNSPN-------TIVT-FTDASQD-ATA-CCLYVV-------NK-------NGA-H-- LLLG---------------------------KSKV-KPLKES------------------ --------------------------------WTIPKLETQALK-MGM-DKTVEVIQA-- -LQDGQIQV-------ERV---MV---------FTPYK-NGHPVLPDNFSIALKRLISVH RTSSKEILKMIDDVFKDQLKKGIIREVDPKKYTQFLVHYNPHQPV-------ITP-QKTT TKC-RVVIDGGSHYK-GK---PSLNDVIHQGPVIL--PDLVDMLIRFR---AGKY--AMI SDVEKAFLQVFLNEQ--DREVTR-----V------LWIRD---L-EK----PLTEENI-V TYHFTRVLFGLNVSPFLLGAT-ILFH------------L------ASHPEK--E-LA-EE M-KKN--LYVDNL-VLTSDGD---ANELERIYRTAK-DA-FSEM-------HMNLR-EFQ SNSM-EF-NERVDEKDR--A---------------------------------------- QEEHM-----------------KV--LG-------------------------------- -----IMW---------------------------------------------------- ----------------------------------------------------------RR SKPFGNTGLDYFGPIT-------------------------------------------- ----------------------------YKKE-DSSDG------------KA-YGA---I -FTCTT--TRMTHIEIVTDCSTTQF-----MMALRRF-IASR-GRPTRIVSDNGSQFVLG QKILK-E---------AT--E-------KCEL-----------TEEVK---EFLGIEQIT ----WTFITPYAPWKGGIYERMVQTSKHAFMKANR--I-----NRL----TLEEL----- --KTS-----IKEVEASINDRP--------LVF------------P-------------- ----------------------ED--------D------------------IDA------ ----------- >143/1-557 ---PTKREVLKVIMSLFDPLGFVAFFLVHGKVLMQD-VWAS-G----------I------ -DWDQ-K-INE--QLFTRWRQWVAFFPQLD---S-LQIP--RCY--F------------- -NSPFPD-NFDRL-ELHV-FVDASDS-AFA-CVAYYR--IET--EN------GIHV-A-- LVCA---------------------------KTKV-APL--K-V---------------- --------------------------------LSIPRLELNAAV-LGV-RILEAVEGF-- -H------T-YSI---SRR---VL---------WS------------------------- -------------------------------------WFLPLGVV-------INPK-K-P GKI-RLIWDAAAK-V-AG---VSFNSYLLKGPDLL--TPLPRVLSGFR---LFPV--AVS GDIREMFLQIKLQAS--DRNSQM-----F------VFRRT---P-EE---------P-VQ VYAIEVTMFGSTCSPSSAQFV-KNAN------------A----EQY-AQHY--P-RAAAA I-KEH--HYVDDY-LDSFR-T---IDEAVRVVSDVK-YV-HSMG-------GFEIR-NFL SNED-EV-LRRT--GEI----EPDS-TKDFAL-----------------------V-RAD AA--E-----------------SV--LG-------------------------------- -----MRWKPADDVFTYTF----------------------------------------- ----------------------------------------------------------PF IRPFTYVGVDYFGPIL-------------------------------------------- ----------------------------VK--VG-R-----S-HV-----KR-WVA---L -FTCLT--VRAIHLEVVYSLSTESC-----IMAIRRF-IARR-GSPAEFHSDNGTCFQGA SNELQ-R-E------TER-RNA-A----------------------LA---TTFTTTKTQ ----WCFIPPAAPHMGGAWERLVRSVKVAIGSIAD--S---P-RRP----DDEVL----- --ETI-----LLEAEALINARP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >1435/1-543 ---PTRXEVTSFQAQNYDPSGMIIPILIKLKKFIST-LC-ERK----------L------ -KWKD-K-IPK--DLIPNWLELKKXFTGNA-----FEIP--RQL---------------- ---V-TSYDYKTV-QLIT-FSDASKD-HYA-TAMYMR--YGY-EDG------KFQS-R-- LIFA---------------------------KSKI-RPSNSGPE---------------- --------------------------------FTIPRMELMSMK-IAT-NAAVNITKE-- -L------H---IKL-DNV---VF---------WS------------------------- -----------------------------------PEYHVPHRGV-------VKN-DSLT TNL-RIVFDASSHMR-NE---LSLNDTLYPGPSIL--QPILGILLRSR---LSKY--MMV ADLEKAFHQVHVQEK--FRNVTK-----F------LWLRN---P-DK----GYTEDNL-V TYRFTRLPFGVTCSPFLLAIT-ILRY------------M-------ELDVQ--E-IN-PR I-IEN--LYVDNT-MFTSN-S---KEDMERCYKQSK-AV-FKKM-------HMNLR-EFL CNVP-DV-MDIIDEKDR--S---------------------------------------- PQQSC-----------------KL--LG-------------------------------- -----HKW---------------------------------------------------- ----------------------------------------------------------TM IAPFKFIGLDYIGPLQ-------------------------------------------- ----------------------------YK-RSS-GCG------------KI-WIL---L -VTCLV--TRAVHLEVVTDHTTLGF-----LNAVKRV-FARR-GVPSHILSDNAPEFKLG YTMIN-Q-------DLRT----------LVNR-----------DNNLT---SFIAQNEIT ----IKLITPLSPWQGGIYERLVALVKNILTKELG--K-----EIR----PFLEM----- --ETL-----VIEAEAIINSRP--------ITP------------N-------------- ----------------------K--------------------------R---------- ----------- >1440/1-548 ---ATRRLVLSFLASLFDPLGLMGPCIQPLKLFFQT-LWE-EK----------K------ -GWDD-V-LSE--KEQTQWESFQENWKD-Q---T-IRIP--RRS--M------------- ----L-QGNPS-L-QLHA-FVDASIH-TFA-AAIYLR--AAEGNQ--------ISV-W-- LIFS---------------------------KNRL-KPK--N----ASKA---------- --------------------------------LTIPRMELMAIL-IGI-RGLKFIADQ-- -I------R-RPIS---NL---HL---------WG------------------------- ------------------------------------EHYIPHQGV-------LAK-GK-- -KL-RVVYDASAHTR-GT---NSLNACLYRGPVIL--PDLVGMLMRFR---CPKF--PLL SDIQAAFLQIALEPE--DREVTK-----F------LWVKD---A-SK----PLAPTNL-S TYRFCRVAFGVISSPFILAAT-LQHH------------L------KGYES---P-VA-KE L-AQS--LYVDNT-LLECE-S---AEEALHKYAESK-AI-LKEG-------FFNLR-EFV TNSP-EV-MKAIPEEDR--L---------------------------------------- NKPKV-----------------KV--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------CR QAPFKTIGIDFLGPT--------------------------------------------- ----------------------------ETRL-AGEKV------------KA-WIL---L -MTCLV--TRAVHLEAMLDTTAESF-----LNVLRRF-ISRR-GKPDLIWSDNATSFKLA QKTIE-H--------------L--T---TPGV-----------DQNTQ---EFFALNKIK ----WRFIPQISPWAGGVYERLVQLCKNCFKRTLG--R-----KVL----SYDQL----- --ITF-----VAEVEATLNHRP--------ITS------------V-------------- ----------------------SE--------GMD--E-------FLPLRPVDF------ ----------- >1441/1-573 ---MTKRQLASEVLRLYDPLGVMQPIIITAKILLQG-LWKT-K----------L------ -GWED-H-IPD--ETLHEWQNLKKSLPKLA---E-LKFP--RRA--M------------- -PSNPV-----RL-ELHG-FSDASSR-AYG-AAIYAF--AVDA-QG------NKSF-N-- LLCS---------------------------KSRV-VPI-------K------------- ---E----------------------------LSLPRKELLGAK-LLA-ELMYRALGI-- -V------P-HTV---DKV---HY---------WC------------------------- --------------------------------------FIPHSCV-------IKPD-STS TKL-RVVFDASAKTT-NG---RSLNDAMLSGPPIQ--SDQFDLLLDFR---CHDK--VLM GDIAKMYRQVVVHEV--DSWFQT-----I------LWRNT---P-EE---------PI-Q VYRLKTVTYGEAASSFLACRA-LHQV------------G----EEL-RTEL--P-EIAAM I-QRR--FYVDNL-MMGGD-S---AEELLDRRRAVE-AA-LMKR-------GFPLR-KWA ANDL-SI-IADIPNHDRETEI------------------------------------RIG DHEII-----------------KT--LG-------------------------------- -----VAWSPREDTFKFLVEEQ-------------------------------------- ----------------------------------------------------------NP SAPFTHTGIDLCGPFE-------------------------------------------- ----------------------------VLPS--KRAK---VKL------TM-YAC---I -FVCFS--TKAVHLEIVENQSTSAF-----IASLMRF-VSLR-GRPEVIYSDNGRNFVGA SRELD-A-------LRKVYNDE-AF------------------QQELI---GSIAEEGIR ----FSFIPPRSPNFGGLWESNIKVAKRLFSAAAR--G-----ASF----NVLEL----- --QTV-----FYQVAAIMNSRP--------LTS------------V-------------- ----------------------LSNAGAPEPLTPG--H-------F-------------- ----------- >1447/1-519 ---PTKREVLRTVMSFFDPMGLITFFLIHGRVLMQD-IWAA-G----------I------ -DWDN-E-INE--RMRCQWRRWIELVPQLT---D-LQVP--RCY--F------------- -PNAIEQ-TYSSL-QVHV-FVDASKS-AYA-CTVYFR--VET--AE------GPLV-S-- LVAA---------------------------RAKV-APL--K-M---------------- --------------------------------LTIPRLELQAAV-LGA-RLLDSVITM-- -H------N-LPV---QKR---VL---------WS------------------------- -------------------------------------WYLPLGIV-------INPK-K-P NKL-RMIWDAAAT-V-DG---ISLNSELLKGPDFL--TSLPTVIGKFR---LYQY--ALA GDIKEMFHRFSIRPE--DRQYLR-----F------LFRDH---P-SQ---------E-PV VYVMDVAIFGATCSPSCAQYI-KNLN------------A----AEF-ESDF--P-RAVNA I-IYR--HYVDDY-LDSFG-T---QEEAIKVGSEVK-QI-HAAG-------GFEIR-NFL SNDP-VI-AMKV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY VRPFTYVGLDYFGPIL-------------------------------------------- ----------------------------IR--CG-R-----S-VV-----KR-WVA---L -FTCLT--IRAVHLEVAHSLSTESC-----VMAVRRF-VARR-GAPLEIFSDNGTNFHGA NNQLR-Q-E------LAE-RSK-H----------------------LA---TVFTNTQTR ----WTFNPPSAPHMGGAWERMVRSVKAAIGTILE--D---K-RRP----TDEIL----- --ETV-----IVEAESMINTRP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >1448/1-546 ---PTKRQVLRTVMSLFDPLGLISHFVVHGKILMQQ-IWRS-G----------T------ -DWDE-P-MSE--ELQDKWISWCQYMQRLD---V-VAVP--RCF--F------------- -KGVNSS-ALDNV-EAHL-FVDASEV-ACG-AVMYLR--FLD--NG------GTRC-A-- LVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSVPRIELQSAM-IGT-RLLESVLTS-- -L------D-IKI---SKR---YL---------WS------------------------- -------------------------------------WYLPLGVV-------QNPK-K-P TKV-RLIWDAKAR-A-GG---VSFNDMLLKGPDLL--VGLMAVLLRFR---QRNI--AIV GDIKEMFHQIRIRNE--VKQSQR-----F------LFRRN---P-ES---------N-TQ IYVMDVATFRATCSPSLAQYV-KNEN------------A----KEF-AETY--P-RTTKS V-TDN--HYVDDF-LDSVD-T---EEEAVKLINEVK-YI-HSQA-------GFEIR-NFC SNSV-QV-LKRV--GE-YEAP----NTVSMNL-----------------------D-KST ES--E-----------------RV--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------AL VRPFTHTGVDYFGPIQ-------------------------------------------- ----------------------------VK--HG-R-----S-LL-----KR-WVA---L -FTCLT--IRAVHVELVHSLSTPSC-----IMAIRRF-VARR-GSPAAFYSDNGTNFVGA SNLLA-K-Q------IQD-IHE-D----------------------CS---VTFTNSATS ----WEFNPPSAPHMGGSWERMVRSVKTAMAAIAE--H---P-HHP----SDEVL----- --QTV-----ATEAEAVINSRP--------LTY------------I-------------- ----------------------PL-------------EA--------------------- ----------- >1449/1-526 ---YTRRGLLSVVNSLYDPLGFVAPITVQGKLLLRE-LTAN-A----------T------ -DWDS-S-LPA--SGQELWDSWKNSLQELQ---H-IQVP--RSY--G------------- -LVSPSG--AKFT-ELSV-FSDASEK-IIA-AVAYLK--TVDS-NG------NCHA-G-- FITG---------------------------KARL-APL--P-E---------------- --------------------------------LSIPRLELCAAV-LSV-NMMETIIAE-- -I------A-VRF---DEI---NL---------YT------------------------- -------------------------------------WYLPSFGV-------YHPK-K-P SQM-RVVFDSSAL-Y-KG---VSLNKVLLTGPDLN--NSLLGVLMRFR---EESV--AFM VDIQQMFHCFKVRPV--DRNYLR-----F------LWFHE---NNPE---------NELT EYRMKVHVFGNSPSPAVAIYC-LRCA------------A----QEG-ETDF--GEDARQF V-EED--FYMDDG-LKSLP-S---PEMAISLLKRTQ-DM-LAGS-------NLKLH-KLA SNSK-KV-MQA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SA EPPFTHVGLDVFGPWS-------------------------------------------- ----------------------------VC--AR-RTRGGFA-ES-----KR-WAV---L -FTCLN--IRAIHIEVIESLTTSSF-----INALRRF-LAIR-GPVKQIRSDRGTNFIGA CKDLQ-I-------PSN-VDKK-A----------------------VE---RFLSDHNCT ----WTFNPPHSSHMGGAWERMIGLTRKILDSMLL--QT--SSSRL----THEVL----- --STF-----MAEVTAIINNRP--------L--------------I-------------- ----------------------PV-------------ST--------------------- ----------- >145/1-556 ---PSKRALLSDLSKVFDPLGFVAPTTVLLKLIFQE-CWFS-A----------I------ -SWDD-P-IPE--TLRRRWQAIIKELPLLS---H-CRIS--RYI--A------------- --ASSP-----HI-ELCG-FADASTQ-AYG-AVIYSR--VRTT-N-------GYRS-R-- LVAA---------------------------KTRV-APL-------K------------- ---P----------------------------ISIPRLELNAAL-LLS-RLLKLVTES-- -L-T----I-P-I---SSS---HC---------WT------------------------- -------------------------------------FYLPHHAV-------LKPE-STT TKC-RVVFDGSGKDS-SG---VSLNERLHIGPPIQ--RDLFGVCLRFR---QHRY--VCC SDIEKMFRKIEVAPH--HTNYQR-----I------IWRSS---T-MD---------PM-Q HYRLRTVTYGLAPSPFLAVRV-LKQL------------A----IDY-EAKY--P-LAARV L-ARD--AYVDDI-PTGCN-S---VGELMKLKDQLI-SL-LDEG-------NFKLR-KWS SNSW-SF-LKSIPKED-CLHGHASIEDN-------------------------------- ----V-----------------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------QA TPCFQHTGLDYAGPIA-------------------------------------------- ----------------------------IKEN--KGRT---PRIG-----KA-WFA---I -FVCLA--TKAMHLEVVSDLTTNAF-----IAAFKRF-ISRR-TRPTDLYSDNGTTFHGS RRALD-E-------MRRLAIDH-MK------------------DKELA---SFAASEGIT ----WHFIPPSAPHFGGIWESGVRSVKLHLRRVIG--A-----NAL----TFEEL----- --STV-----LAQIEAVLNSRP--------LCA------------N-------------- ----------------------GD--------SS-----------LDPLTPAHF------ ----------- >1450/1-604 ---PTMRNIYKVVASQYDPLGFLVPYITRAKILIQS-LWAK-Q----------R------ -EWDD-PLLPT--EILKTWHDWQGELQHLS---Q-LTLP--RCY--V------------- -SSQLDS-LNCKR-QVHI-FSDASER-AYG-SVAYLR--SEDL-KG------NVEV-A-- FLTA---------------------------RSRV-APK--R-Q---------------- --------------------------------LSVPRLELCAAL-TGA-QLASLLAKE-- -L------T-LPI---ESF---VL---------WT------------------------- ---------------S---------------KKEEESWFIPHHMV-------SHN----- AKN-RVVFNCSFS-Y-QG---KNLNNLLLPGPALG--SSLLGVLLRFR---EHAV--AFS SDIKGMFHQVRLLPE--DKPLLR-----F------LW-RD---LKRE---------ELPR VYEWQVLPFGTTCSPCCATYA-LQRH------------I----VDH-SQQ---GDNVRHS L-ERC--FYVDNW-LQSVA-T---PDEAKELLDTGM-NL-LAEG-------GFELR-QWA CNFP-NV-IEHL-------SKEARSESSERWL-----------------------NQTES -DPQE-----------------LA--LG-------------------------------- -----LRWMCQSDTLGYQTRLDNCSTPTMRNIYKVVASQYDPLGFL-------------V ----------------------------------------------------------IF KPPFFSTGMDCFGPFT-------------------------------------------- ----------------------------VK--LG-R-----R-SE-----KR-WGI---L -FKCLT--TRAVHIDLLSSLDTDSF-----LMSLRRF-ISRR-GKPSELLSDQGTNFKGG ERELQ-Q-------SFTSMCPT------------------------LQ---KELAKQQIK ----FRFNPPGSPHFGGVWEREIRSVKSALYATVQ--R---Q--SM----TEEVL----- --NTV-----LTEIEGILNSKP--------LGY------------V-------------- ----------------------ST-------------DIADPNPVTPNIL---------- ----------- >1453/1-546 ---PTKRQLLRVQMTIFDPLGFIAHFVMRLKVIIQE-LWRS-S----------I------ -GWDD-S-IPP--QQEEKWLKWTQDLPEIA---G-LKIP--RCF--R------------- -NQTGTD---AEI-ELHT-FVDASEM-GFA-AVCYLR--FED--KG------IIEC-S-- IVSA---------------------------KTKV-API--S-F---------------- --------------------------------LSIPKSELQAAV-IGV-RLAETVQRS-- -V------S-FTI---HRR---MF---------WT------------------------- -----------------------------------RIWYLPVFPV-------FNQN-K-P GKL-RLVWDAAAK-T-KG---VSLNSMLLKGPDQI--TCLLSVLIRFR---EHKI--AVC GDIREMFHQVLVKKD--DQQCQR-----F------FWQQG---E-LE---------DEPE VYVMQVMTFGACCSPSIAQYV-KNHN------------A----EQY-MSQQ--P-EAVNA I-IQQ--HYVDDM-LLSAE-T---EAAAINTATKVA-EI-HAAA-------GFEMR-NWI SNSA-TV-SRSL--LG---SSAP--EEKNLDI-----------------------G-E-T QT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------GY TRPFTHMGIDYFGPIL-------------------------------------------- ----------------------------VT--VG-R-----R-VE-----KR-WGV---L -ATCLT--TRAIHVELAASLSTDSC-----IMAIRNI-WARR-GTPAAIYSDRGTNFQGA SKIVH-E-------HKDKPDYA-G----------------------IE---QGLTTPGIT ----WIFNTPSAPHMGGAWERLIQSVKKNLTVALK------E-KRP----SHETL----- --ANA-----LTEIENVVNSRP--------LTA------------V-------------- ----------------------PL-------------DD--------------------- ----------- >146/1-564 ---WTRRKVYSVIAQLWDPTGITAPVISWAKIRMQL-LWVA-T----------Q------ -GWDD-P-LRP--DLAGRWTEFYQQLPELS---K-ISVD--RCA--F------------- --VE-N-PV--HV-EFHV-FADASEA-AYG-ACIYAR--SISQ-SG------LVKI-S-- LLAA---------------------------KSRP-AGL-------K------------- ---K----------------------------VTLARLELCAAL-MAA-RLYRKVVQA-- -L-K----M-E-G---TES---WF---------WS------------------------- -------------------------------------CYLPHHPV-------FKES-STT TKI-RPVFDGSAKTT-SN---FSLNEALMVGPVLQ--DPLFDLVLRFR---KKQV--ALV ADIEKMYLQVKVHPD--DTPLQR-----I------LWRPS---P-SE---------PI-R TYEMLRVTFGLAPSSYLATRC-MQQL------------A----QDE-GEVY--S-RAKEA L-LRD--FYVDDF-IGGAD-S---EEEALLLRQELE-QL-LPKG-------GFRLR-KWV SNAT-GA-LAGLAADDLGTQT--T-L-SF----------------------------D-- -QEQV-----------------KT--LG-------------------------------- -----INWQPGPDVLGIDV----------------------------------------- ----------------------------------------------------------TP SRAFTVTGVDYCGPVY-------------------------------------------- ----------------------------LKPV--HRRA---AAQ------KA-YIA---V -FVCFS--TKAVHLELVGDLTTAAF-----LAALRRF-VSRR-GLPSEIHSDNGLNFQGA SNHLR-E-------LYELLRDT-KV------------------ITEIT---SEASRRGIE ----WKFIPPRAPNFGGLWEAAVKSAKTSLVRVLG--Q-----RQL----SFEDM----- --ATV-----LTQIEAAMNSRP--------LTP------------L-------------- ----------------------SE--------DPD--E-------L-------------- ----------- >1464/1-529 ---TTMRNIYRVLASQYDPIGLIIPFTTRAKILVQM-LWNK-Q----------R------ -EWDD-PLLPK--DILEAWLAWESELPHLE---K-LSLP--RCY--T------------- -KPHLDH-PSCTR-EVHI-FCDASER-AYG-CVGYLR--TEDP-HG------QVEV-A-- FITL---------------------------RSRV-APK--K-Q---------------- --------------------------------LSVPRLELCAAL-TGA-QLAHLLQRE-- -L------T-LNI---ERI---TL---------WT------------------------- ---------------W---------------KSSSESWFIPHHMV-------THN----- EKA-RIVFNCSFT-H-QG---HNLNELLLPGPNLS--SSLLGVLLRFR---EHAT--AIS SDIRGMFHQIRLLPE--DRPLLR-----F------LW-RD---LSKE---------SPPS VYEWQVLPFGTTCSPCCATYA-LQRH------------V----TDH-SQE---GDEVRDA V-ERH--FYVDNW-LQSFP-S---PEKAKALVNKLR-EL-LNGG-------GFELR-QWT SNVP-EV-IRHL-------PPA-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------I ----------------------------------------------------------LH SPPFFSTGMDCFGPFL-------------------------------------------- ----------------------------VK--IG-R-----R-NE-----KR-WGI---L -FKCLT--TRAVHIEVLTSLDTDSF-----LMSLRRF-ISRR-GKPAEVLSDQGTNFKGG ERELS-D-------SFKDMHPS------------------------LQ---TLLAEHQIK ----FIFNPPSAPHFGGSWEREIRSIKTALYATLN--A---Q--SV----TEEML----- --NTI-----LIEIEGILNSKP--------LGY------------I-------------- ----------------------SS-------------DV--------------------- ----------- >1465/1-556 ---PTKREVLRILMRIYDPLGLLGNVLMFLKVLLQE-IWRA-G----------V------ -GWDE-Q-IGG--RLAEQWERWTSILPAVC---Q-IKIP--RCY--R------------- -QRTSAL--PRNV-QLHI-FCDASEN-GMA-AVAYFR--FEE--GE------TIEC-A-- LIGS---------------------------KTRV-APL--R-F---------------- --------------------------------LSIPRLELQAAV-IGA-RLAHTIHKS-- -H------R-LII---TRT---IF---------WS------------------------- -------------------------------------WFLPTFPV-------TNPN-K-P GKI-RIVFDAAAK-S-NG---VSLNTFLLKGPDQL--VDLLTVLYKFR---EHRI--GVV GDIKEMFFQVAMRPE--DQRSQM-----I------LWNGG---E-TD---------KAPD VYVVTVMTFGAACSPCCAHYV-KNLN------------A----EKY-RDEF--P-RAFEC I-VKE--HYVDDM-LASVE-T---EDEAIKLAKDVR-HV-HANG-------GFEIR-NWL SNSH-LV-MEQL--DV---PVKI---EKDVNV-----------------------GTD-A RT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------IA QRAFTCTGIDYFGPIN-------------------------------------------- ----------------------------VV--VG-R-----R-VE-----KR-WGV---I -FTCLT--TRAIHLEIAHSMTSSSC-----ILAIRRF-IARR-GTPREIISDRGTNFVGA SRELK-E-------ARKSVDEN-T----------------------LI---EEFTSPDLK ----WTFNPPAAPHFGGCWERLVQSVKKVFAQLEL------P-RLP----NDEVL----- --QST-----MAEIEMIINSRP--------LTY------------V-------------- ----------------------PL-------------DDDLAPPITPNDL---------- ----------- >147/1-560 ---ATKRRVLSEIGKFYDVLGLLSPVIIKAKILMQR-VWLA-G----------L------ -SWDV-L-LEG--GMMDTWHQFQCALPDVR---D-IRIP--RYV--I------------- --GPGNPGL-----ELHG-FSDASKV-AYG-AVTYVR--SLLP-NG------KCKM-R-- LLCS---------------------------KSKV-APT--K------------------ -----P--------------------------LDIHRLELLALR-LLS-KLVVKVIAA-- -LN-------LPF---RNV---VL---------WC------------------------- -----------------------------------------------------PPS-SST TKL-RVVFDASAKMSPTS---VSLNEALQVGGTVQ--NDLFSILLAFR---KHPV--AFT ADLSKMYRQIRVAPS--DTRFQR-----I------FWRAD---P-SE---------FI-R VLELTTVTYGTASAPFLATRC-LVQL------------C----DDE-GENF--P-LAAKI V-REA--CYVDDI-LSGAS-S---PKEAIDCLTQLQ-GL-LSRG-------GFPIH-KWT SNEP-AV-MERIPESDREKLI------DLD---------------------------GL- IGGVV-----------------KA--LG-------------------------------- -----LYWSPGDDEFRFTVTQA-------------------------------------- ----------------------------------------------------------TE NLPFDEVGVDYAGPIL-------------------------------------------- ----------------------------VK--VGTRKP---QIV------KA-YFA---V -FVCMV--TKAIHLELVSDLTTEAF-----LAALQRF-VSRR-GVPRRIHSDNGTNFKGA KTELH-E-------LYVLFNER-AF------------------NDRIQ---TYCQPKEIT ----WSFIPPGAPNFGGLWEAAVKSTKYHLKRILK--N-----AQL----TFEQY----- --ATV-----LAEVEAVLNSRP--------LFA------------T-------------- ----------------------ST--------DPA--D-------P-------------- ----------- >1470/1-557 ---FTRRGVLSTVASIFDPLGFVAPFILVGKRILQR-MCQE-K----------L------ -GWDE-P-LPL--DLKPQWEAWLKDLKNLP---T-INIP--RCY--I------------- -TSTFKH--VQQC-ELHS-FSDASVS-GYG-VCSYLR--TVTK-TG------EVQC-N-- FIMG---------------------------KARV-APT--K-V---------------- --------------------------------TTIPRLELTAAV-VAV-RTASFLKKE-- -L------D-IQG---LKE---YY---------WT------------------------- ---------------E---------------INNLPAWYIPHHGI-------YHPQ-K-P NKI-RVVFDASAK-Y-QN---TSLNEQLLTEPDLT--NTLVGVLCRFR---KGRV--AIM CDVERMFHQFHVAPQ--DQDYLR-----F------LWWEN---GNME---------HPAS VFRMKVHLFGAASSPGCANFG-LKHL------------A----TQG-ASKF--SQAVVKF I-QRN--FYVDDG-LAAVD-S---EQEAIHLVKEAR-EL-CDTG-------KLHLH-KFI SNSK-EV-IATI-------PKEERAAGDTDLD-----------------------LALGE -PKME-----------------RA--LG-------------------------------- -----VQWCVTSD----------------------------------------------- ----------------------------------------------------------EA MSPFTYSGMDCFGPFY-------------------------------------------- ----------------------------VK--EG-R-----K-EM-----KR-YGL---L -FTCMC--SRAIPIEVLDDLSTDCF-----LNALRCF-ISIR-GNVSQLHCDQGTNFVGA KNEFL-S-------LTQA-SKE-K----------------------AK---EL----GIS ----FNFNPPASSHMGGVWERQIRTIRNVLSSILD--E---SASRL----DTSSL----- --RTF-----LYETMSVVNSRP--------LTV------------E-------------- -------------------------------------------------F---------- ----------- >1472/1-579 ---PTKRTLLSTIAKVYDPLGLVSPIVLQAKLILQR-VFE-AN----------Y------ -KWDA-P-LDD--KLSEDWLKLMELWSTTS---E-ITIP--RLI--K------------- ------NNP--KK-ELHC-FTDASGQ-GFG-AAAYLR--T-FNTFN------GGTT-K-- LIFA---------------------------KSLV-KPA--S---LPHNA---------- --------------------------------STIPKLELQALT-LGA-KIIRYLQKE-- -L------I-IEAN---SI---TL---------WS------------------------- -----------------QLEKGVIEVVKNPNESTGPVHYLPHRAV-------VRE-DKNT TKL-RIVMDASARPP-SQRSAPSLNNCLHTGPLLL--KQLVGILLRFR---LMDR--VIL ADIEKAFLQLGVRET--DRDCTR-----F------LWVNN---P-KDVPLENFQYAQC-I VYRFCRVSFGLTVSPFLLNAT-IREH------------L-------GLFDS--P-VA-RT I-EEN--LYVDNI-MIQVK-E---GENAKQMCLESI-EI-FQSG-------GMTLR-EFS GLLP-NE-LKGFPEENL--AT--------------------------------------- DQNNV-----------------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------NV ARPFLHCGVDYFGPMN-------------------------------------------- ----------------------------VKG--QTTTE------------RV-YGA---L -FTCLT--IRAIHLEMATDASAETF-----LQAYRRF-IARR-GTPSIMVSDNATNFTLG SKIIK-K--------------M-NW---DLYS-----------SKELQ---DFIKFRGTE ----WKFITPRNPREGGAWERLVGVTKTALKRCIG--K-----KLL----TTTEL----- --TTL-----FCEIEAIVNSRP--------LTF------------M-------------- ----------------------SD--------K-E--P-------LNALRPIDF------ ----------- >1477/1-550 ---CTKRNILSVIARIWDLMGFVAPVTLWAKLIIKS-LWAN-N----------I------ -DWDE-T-PRP--EIVAAWHRFVSELPILE---N-VRIP--RHTGI-------------- -------VMECIV-SLLG-FADASEK-AYG-GVVYLH--VYFPQTN------KFTI-T-- LVCA---------------------------KSRV-APL--R-C---------------- --------------------------------VSLARLELCGNL-ILA-KLMRAIIDS-- -Y------S-HRCKI-SNV---FA---------FT------------------------- ---------------------------------------IPHHGI-------VRKD-KST TKL-RVVLDGSMKSS-SG---LALNDILQVGPNLQ--NDLFRIILNFR---LFNV--AIS ADIRQMYLRILVKDE--DRKFLR-----M------LYRFD---P-SE---------EI-K LYEFTRVPFGLCCSPFLAIRT-VRQL------------V----TDE-GSQF--P-LAAPV A-DSD--VFTDDL-ATSCA-N---EETAVELSNQLI-KM-FHAG-------GFDLV-KFS SNSP-EV-LSKIPSSHREFEVIEF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QE TKAFYHTGIDYAGPLR-------------------------------------------- ----------------------------IIPY--RRRG---VRSQ-----KA-YIC---L -FICLV--TKAVHLELSTDLSTAAF-----LNAFKRF-IARR-GPIKVVYTDCGTNFLGT HSYLK-E-------MYKLISSE-QY------------------ADKFA---NELRDNNID ----WKFNPPSAPHFGGIWEGNIRSVKTHLNKIVG--N-----QLL----TFEEM----- --LTT-----LAQIEALLNSRP--------LSV------------L-------------- ----------------------SS--------DPC--D-------PQALTPAHF------ ----------- >1478/1-546 ----TKRGLLXLAASVFDPLGALTPFTVRAKLLLQS-LWQT-G----------I------ -SWDD-P-LPP--EISGKWDQWRSDLGDLH---Q-IALP--RAY--L------------- -PYSPME--VSRL-ELHG-FGGASEA-AYA-AVVYLR--ATQS-TG------VTRV-S-- FVAA---------------------------KSKV-APL--K-K---------------- --------------------------------LSVPRLELSAAL-LCV-RLVRYVLQK-- -L------A-LPV---DAC---YC---------WS------------------------- -------------------------------------WYLPHHVV-------YLQ-GPEG QKA-RIVFDGSAKYQ-GT----SLNDHLDAGPKVQ--TDLMGILLRFR---RYRV--ALQ SDIAKMYLQVGLHED--ERDFCR-----F------LWRDR------S--------GTL-D IYRLTRVCFRLACSPYLAIQV-VNFH------------L----EAHRTLFP--S-VA-DE I-RSC--MYVDDL-VVSRD-S---VADAKLFVHQAS-DL-LSRG-------GFHLT-KWA SNAP-EA-LSDLPAEDCSSVD--------------------------------------- RSRLW-----------------KA--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------NP AGPFSNVGIDFAGPLM-------------------------------------------- ----------------------------IRD-EGS-KH---GSK------KA-YIC---L -FTCMV--VRAIHLELVPDQTIESF-----LRALRRF-VARR-GRPDTIQSDNFRTFHQA NVFLK-H-------LFSGQN-----------------------WETVQ---RHLASERVE ----WIFITERAPWCGGYWERLVRSVKTALKATLG--Q-----CLA----SPDEL----- --RTV-----LCEVEARVNDHP--------LTF------------V-------------- ----------------------GS--------DIQ--E-------EM------------- ----------- >1479/1-527 ---FTRRGVLSVVNSLFDPLGFVAPVTIKGRLLLRE-LSRG-N----------F------ -EWDS-P-LPQ--EMYDEWRRWQDSLQDLK---R-LHIP--RTY--V------------- -LFSISQ--AEYT-ELCV-FSDASTK-AIA-AAAYLK--VGQG-DG------HTEV-G-- FVMG---------------------------KAKL-ASV--T-E---------------- --------------------------------PTIPRLELCAAV-LGV-ELAEVLKEE-- -L------D-MKM---DKT---TF---------YT------------------------- -------------------------------------WYLPSFGV-------YHPQ-K-P GKI-RVVFDSSAK-F-DG---VSLNDVLLSGPNLN--NTLLGVLLRFR---KEPV--AIT ADIEQMFYSFVVRKD--HRDFLR-----F------LWYAD---NDLS---------KEVV DYRMRVHVFGNSPSPAVAIFG-LRMA------------A----REA-EDKY--GTDARHF I-ERD--FYVDDA-LKSFP-T---EAEAIDVLQRAQ-KM-LALS-------NLRLH-KIA SNRP-EV-MN-----------------------------------------------F-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QT DPPFSYVGLDVFGPWE-------------------------------------------- ----------------------------VT--AR-RTKGGHA-NS-----KR-WAV---L -FTCMA--TRAVHIEVIETMSSSSF-----INALRRF-FAVR-GPAKQLRSDCGTNFIGA SKELK-L-------DPLKSGEM-S----------------------VD---KYLLSQKCT ----WVFNPPHASHMGGTWERMIGIARRILDSMLL--QA--RHPEL----THEVL----- --TTL-----MAEVTAIINARP--------L--------------V-------------- ----------------------PV-------------SS--------------------- ----------- >1483/1-525 ---FTRRGVLSTVNSVFDPLGMLAPVTIEGKHLLRE-FCAD-K----------F------ -EWDA-P-LPE--EKRKQWELWRDSLHDFK---R-LHIP--RPY--I------------- -PKSLSK--AKHK-ELCV-FSDASVK-AIG-AVAYLR--TVQV-EG------DVKV-G-- FILG---------------------------KAKL-APL--S-R---------------- --------------------------------PTIPRLELCAAV-LAV-EVADLIQDE-- -L------D-LKL---DSV---KF---------FC------------------------- -------------------------------------WYLPTFGV-------FHPQ-K-P ENI-RVVFDSSAK-Y-SG---MSLNNALLKGPDLN--NSLVGVLIRFR---KEQV--AAV ADIQQMFHCFLVRSD--HRNYLR-----F------LWHRD---NDMS---------KEII DYRMRVHVFGNSPSPSVAIYG-LRKA------------I----QEG-GHKY--GPDTVKF V-ERH--FYVDDG-LISLP-T---DEEAISLLKRTQ-AS-LSES-------NLRLH-KFA SNSD-TV-LQA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QV SPPFTYVGVDVFGPWT-------------------------------------------- ----------------------------VI--TR-RTRGGHA-ES-----KR-WAM---L -FCCMT--SRAVHIEIIASLDTSSC-----INALRRF-FAIR-GPVKQIRSDCGTNFVAA AKELG-L-------SQK-ELNV-T----------------------MQ---TFLSQQNCE ----WVFNPPHASHMGGSWERLIGLSRRILDAILL--RD--N-IQL----THDVL----- --CTL-----MMEVAAIINARP--------L--------------V-------------- ----------------------PV-------------SS--------------------- ----------- >1487/1-543 ---YTKRGVLSMINGVFDPLGFLAPVMVQARVLFRE-MTTH-Q----------V------ -DWDD-K-LPE--MYKSVWESWTSGLSELQ---S-VSVP--RNY---------------- -PICLEN--GV----LNV-YCDASEV-AVA-AVAYLI--DVDQ-E-------KPSA-S-- FVFG---------------------------KSKL-APR--L-G---------------- --------------------------------HTIPRLELCAAV-LGT-EIARIVCRE-- -L------N-IQA---STV---VF---------HS------------------------- -------------------------------------WYLPMFGV-------YHPR-K-K DKI-RGVFDSSAE-F-MG---HSLNKVLLKGPDLT--NDLVGVLMRFR---QGPV--AVC GDIESMFYCFSVSEE--HRNFLR-----F------FWHED---NDFA---------KPLT EYRMLKHVFGNTPSPAVANYG-LRDL------------T----SDA-E------PDVRDF V-HNN--FYVDDG-LAACD-D---SNTAVSLMERTRAKL-KEKA-------GIRLH-KIA SNSQ-VV-LDAF-------EPEEVQKDIRNLT-----------------------L-SDG -APTQ-----------------RS--LG-------------------------------- -----VQW---------------------------------------------------- ----------------------------------------------------------KA GPPFSQVGVDCFGPWE-------------------------------------------- ----------------------------VV--TR-KTRGGAA-QS-----KR-WGM---I -FSCLT--SRAIHIEVLEEMSTSSC-----INALRRF-MAVR-GKVETFWSDRGSNFVGV ------------------LNDK-V----------------------FH---TYLGENDTE ----WKLNPPHAPHMGRVWERNDGLFKGILNGILL--EA--KQRDL----THETL----- --ATF-----MMEAMAIVNARP--------L--------------V-------------- ----------------------PL-------------SSDPEDT---------------- ----------- >149/1-528 ---WSRRKVYSLVARIYDPLGLVAPVTSWAKINMQS-LWLA-T----------D------ -DWDE-E-IPA--VMQERWYAFQSQLGLLK---E-VKFS--RHA--V------------- --VH-N-PV--AV-QLHC-FSDASEA-AYG-ACVYVR--TIGS-SG------EVVV-E-- LLAA---------------------------KSRP-APL-------K------------- ---R----------------------------VSLARLELCGAL-LAA-RLQKVVRQA-- -L-R----I-P-D---VET---FM---------WT------------------------- --------------------------------------FLPHHPV-------IKAS-STS TKV-RPVFDGSASTD-GG---KSLNDLLMTGPVIQ--ENLLALLLKFR---MRSV--ALV ADIKQMYLQVKVHPD--DTRFQR-----V------LWRGS---S-VE---------SI-E VYELQRVTFGLAPSSFLAIRV-LQQL------------A----IDE-GENF--P-LARQA L-LED--FYVDDY-IGGAS-S---EEEAVRLQAELT-LL-LRKG-------GFHLT-KWN SNKP-DV-LSSVS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MP ARPFSIVGVDFCGPIY-------------------------------------------- ----------------------------LKPV--HRRA---AAE------KA-YIS---I -FVCFS--VKAVHIELVESLSTHAF-----LAAFRRF-VARR-GLPSEVYSDNGLNFQGA SKVID-D-------FYTLMNSD-SA------------------VEDIS---RYAVGAGVK ----WHFIPPHAPNFGGLWEAAVKAAKRVLLKVVG--D-----RQL----AFGEM----- --STV-----LAQVEAQLNSRP--------LTP------------L-------------- ----------------------SE--------DPE--E-------L-------------- ----------- >1494/1-553 ---PTKRQVLKLVMSLFDPCGFISHFIVHGKILMQR-IWRT-G----------T------ -DWDE-Q-ILP--ELQEMWKDWTQLLKRLD---D-VKIP--RCV--F------------- -GGADSK-LPASI-QLHL-FVDASEL-AYA-CVAYLR--IVQ--AG------TVHC-G-- IIAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAGV-IGC-RLMETICSS-- -L------D-LSI---ESR---HI---------WT------------------------- ---------------S---------------TENNRLWYLPLGVV-------RNPK-K-P QKV-RLIWDAAAR-V-NG---LSFNDMLLKGPDML--TSLFNVLLRFR---QRSV--AIC GDIREMFHQIQIISE--DKQYQR-----F------LFREH---L-DD---------P-PQ IYVMDVATFGAACSPCSSQFV-KNKN------------A----EEF-KANY--P-KATEA I-IKA--HYVDDY-LDSVD-T---VEEAVKLVAEVK-HV-HAQG-------GFEIR-NFS SNSE-EV-LEQL--GE-SQSL----EKKSLSM-----------------------D-ASV YI--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PN IRAFNYTGIDYFGPLL-------------------------------------------- ----------------------------VK--QG-R-----N-LV-----KR-WVA---L -FTCLA--TRAVHLEVVHSLSTQSC-----VMAIRRF-VARR-GSPSAFYTDNGTCFAGA SNLLR-E-Q------LQA-IHE-D----------------------CA---DTFTNARTT ----WHFNPPSAPHMGGCWERMVRSVKMAMMAITE--H---P-RHP----SDEVL----- --ETV-----LLDAEAMINSRP--------LTF------------I-------------- ----------------------PL-------------EN--------------------- ----------- >1497/1-563 -----KRTILTFMASHFDPLGLISPLILPIKIFLQS-LWN-EK----------V------ -DWDE-N-LNE--KTINEWKLLTQNWDANS---C-FSIP--RYP--S------------- ----RLPTTGRKY-QLHC-FADASSM-AMC-AAVYLR--ISKDCSP------ISDV-C-- LIFS---------------------------KTKV-KPI--N----KNKL---------- --------------------------------LSIPRLELIAAL-MGS-RALKFTSSE-- -L------S-CINLD-KSI---YL---------WS------------------------- ------------------------------DNYSPPLHYIPHHAV-------IKA-SNG- -KI-RIVYDGSAKVG-RE---LSLNECLYPGPVIL--PDLVGLLLRFR---IPKI--AII SDIAKAFLQVSVHPD--HRDCTR-----F------LWLKN---I-EL----PPSTSNV-E IYRFCRVSFGLAPSPFLLAAT-VQHH------------L------SLFPS---P-LS-SE I-STN--IYVDNV-FLSAE-T---PKEGKEKSNNTI-EL-FNKA-------NMKLQ-EFV SNSS-ES-IAHLPEKIK--L---------------------------------------- IGNKQ-----------------KF--LG-------------------------------- -----LDW---------------------------------------------------- ----------------------------------------------------------EP SPPFTAVGLDFCGPLY-------------------------------------------- ----------------------------IKTPFLVPNQ----RRNTKIETIKHWIT---V -WVCLS--TRAVALDLISDLTIQSF-----SLAFRRQ-TAKY-GVIKNIYCDNAPTFISA KNFLS----------------------------------------------EQANLSPPN ----WNFRAPMAAWKSGHYERSMALIKYHLKRTLS--G-----GAIPRSYLFHEV----- --LTI-----LLEIENIINSRP--------ITF------------E-------------- ----------------------SA-------------NPLEPRALSPADI---------- ----------- >1498/1-574 -----KRKIVSEIATIFDPLQYFAPLYLEGKLIISS-IADH-N----------I------ -KWTD-I-VNE--ETVLKMIEYRKKIDNSS-----LKFR--RHI---------------- -----DYQKEEPV-GIAI-FTDASET-TYG-ACVYLKTKKEGE-EG------QFDT-H-- LLIA---------------------------KQRI-APKIKT------------------ --------------------------------LTIPRLELLGIL-IGV-RLLKYVLNQ-- -M------K-IAV---NAI---EI---------FS------------------------- -------------------------------------FYIPYQLV-------FNNN-SNT TKV-RTVFDASSKKRGE----ISLNNALHQGPSLI--PDLQGILLRIR---IGKY--VLS GDIEKAFHAVEVNPE--DRDALR-----F------LWLKD---P-NM----PPSN-DNIR HMRFTNLPFGVNCSPYLLSMAILYGI------------Q--------HSNA--PKELIEA I-ENM--CYVDNM-FMTTD-E---IEKLPELYTQTK-HY-FKQI-------GMNIR-EFS VNCP-EN-F-------INPEDRTTNQ---ENI---------------------------- ----------------------KI--LG-------------------------------- -----YNY---------------------------------------------------- ----------------------------------------------------------TE CRPFQHVGVDFMGPIK-------------------------------------------- ----------------------------TQRRNSTEIE------------KS-HIA---L -FTCAT--TRLIHLELVRDLTTDEF-----LLALSRF-MSRR-GYPDTITSDNAATFKLT AEILD-K-------CSTKDNDF-LVELAIAKLENRKSQEENKKISTLD---KEMSSKGIK ----WYFNTALSPWQGGFFERLVGLTKKSLKHALG--D-----EEF----RTKDL----- --ETI-----MIQCESLVNRRP--------ITY------------I-------------- ----------------------DE--------DNE--D-------WKVLRPIDI------ ----------- >15/1-552 ---CTKRQVLSDVSRIFDPLGLLAPIVVQFKILFQK-LWLL-N----------L------ -NWDD-E-LPS--KLANNWLKWRADLDNLH---K-LQIP--RLV--K------------- --SDKQ-----RI-ELHG-FSDASTK-AYS-AVVYSR--VVND-DG------TISV-A-- ILAA---------------------------KTRV-APL-------K------------- ---Q----------------------------QSLPRLELCGAL-LLS-QLLQSIKAG-- -L-M----N-N-D---VTI---YA---------WS------------------------- ------------------------------EIPKGRNFYLPHHPV-------L------G RKL-RVVFDGSYQDA-KG---MALNDTLSIGPSIQ--RDLFAVCLRFR---MYKY--VFS ADIVKMFRQIWVSEK--HRDYQR-----I------VWRED---P-SD---------PI-K HFQLCTVTYGTSCAPFLAVRV-LEQL------------A----ADH-KHEF--P-NAAKI V-LED--FYVDDV-LTGAN-S---EDELLRNRDELV-QL-MSCA-------NLELG-KWV SNTK-RI-KSEDNTDS------SQ------------------------------------ --SPV-----------------KV--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TQ ALPFVNTGCDYAGPIL-------------------------------------------- ----------------------------LKDA--KVRK---PRIS-----KG-YIC---L -FVCMV--TSAIHLELATDLSTETF-----LAALRRF-FSIR-GKCNRMYTDNGTNFIGA KRSLD-E-------MQQLLSSS-QH------------------KDQIV---NTLADEGIQ ----WTFIPPRAPHWGGKWESAVRCVKLHLRRVIG--N-----TTL----TYEQM----- --RTL-----LAQISAVVNSRP--------LCY------------T-------------- ----------------------SD--------TD-----------DSYLSPAHF------ ----------- >150/1-545 ---PTKRIILQCVMSFYDPVGFLSPLLVHGKIIIQE-TWRS-G----------T------ -DWDE-P-VTD--EIFNRWLSWTRILPAIE---T-VKVQ--RCF--F------------- -GDESIN-NITSV-QLHI-FSDAGDD-AYG-CVAYLR--YRV--AG------EVRC-T-- LVGS---------------------------KAKV-APL--K-L---------------- --------------------------------TSTPRLELQAAV-IGA-RMMTTLLAS-- -L------P-VSI---QEQ---FL---------WV------------------------- -------------------------------------WFLPLNVV-------VNPK-K-P GKI-RLTLDAAAK-A-GG---TSLNDMLLKGPDML--VSLLDIINHFR---GRRI--GFG GDVKEMFLQIRMRQP--DTRFQK-----F------LFRQD---P-SK---------N-PD VYVMDVVIFGAKCSPCNAHFA-KDTN------------A----REH-ASQF--P-AAADA I-INR--HYVDDY-FDSAD-S---EDEAIQRAREVR-EV-HSLG-------GFEIR-NWV SNVP-KV-LEAL--GE------EGKPTKTLCY-----------------------D-KTL ES--E-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------PF VRAFSYVGLDYFGPID-------------------------------------------- ----------------------------VT--VG-R-----R-KE-----KR-YVA---L -FTCLV--VRAVHCEVAYSLSTESC-----KQAIRRF-IRRR-GSPVEIFSDNGTNFQGA SRELR-E-E------LER-IDR-D----------------------CA---NTFTGTNTK ----WTFNPPSAPHMGGVWERMVRSVKEAMAA-LS--D---G-RRM----TDEIL----- --VTT-----LAEAEYLVNSRP--------LTY------------S----GTEDA----- ------------------------------------------------------------ ----------- >1505/1-546 ---PTKRQLLRVQMTIFDPLGFIAHFVMRLKVIIQE-LWRS-S----------I------ -GWDD-S-IPP--QQEEKWLKWTQDLPEIA---G-LKIP--RCF--R------------- -NQTGTD---AEI-ELHT-FVDASEM-GFA-AVCYLR--FED--KG------IIEC-S-- IVSA---------------------------KTKV-API--S-F---------------- --------------------------------LSIPKSELQAAV-IGV-RLAETVQRS-- -V------S-FTI---HRR---MF---------WT------------------------- -----------------------------------RIWYLPVFPV-------FNQN-K-P GKL-RLVWDAAAK-T-KG---VSLNSMLLKGPDQI--TCLLSVLIRFR---EHKI--AVC GDIREMFHQVLVKKD--DQQCQR-----F------FWQQG---E-LE---------DEPE VYVMQVMTFGACCSPSIAQYV-KNHN------------A----EQY-MSQQ--P-EAVNA I-IQQ--HYVDDM-LLSAE-T---EAAAINTATKVA-EI-HAAA-------GFEMR-NWI SNSA-TV-SRSL--LG---SSAP--EEKNLDI-----------------------G-E-T QT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------GY TRPFTHMGIDYFGPIL-------------------------------------------- ----------------------------VT--VG-R-----R-VE-----KR-WEV---L -ATCLT--TRAIHVELAASLSTDSC-----IMAIRNI-WARR-GTPAAIYSDRGTNFQGA SKIVH-E-------HKDKPDYT-G----------------------IE---QGLTTPGIT ----WIFNTPSAPHMGDAWERLIQSVKKNLTVALK------E-KRP----SHEAL----- --ANA-----LTEIENVVNSRP--------LTA------------V-------------- ----------------------PL-------------DD--------------------- ----------- >1509/1-578 -----KRFVLSSIAKIYDPLGLIDPVKALAKQIMQQ-IWEL-K----------K-TDGKN WDWDD-E-LPS--DLQQAWVHFQQHLEPLR---N-LQIP--RAA--V------------- -HTSIH-----NV-QLHV-FCDASEK-GYG-ACCYIR--DDND-EE------NITS-Q-- LLTS---------------------------KSKI-APL--S-Q--K------------- --------------------------------LTIAQLELCAAK-LGS-DLFAKVKEA-- -IPT--------F---SNV---YF---------WT------------------------- --------------------------------------YIPHHPV-------FKAE-STT TKC-RVVFDASAKTT-SG---YSLNDALMVGPTIQ--QESFTILLRFR---SHII--AAI ADVEKMYRQVWVHPE--DRPLQR-----I------FWRDS---I-NQ---------PI-R TFQLNTVTYGTASAPFLAVRA-LKQI------------I----IDH-GKEF--P-KAAE- R-MDD--FYVDDF-ISGAD-S---IADVQQLYTEAT-TL-LAKG-------GFTLR-KWC SNDP-EA-LIEIG-NIKNV--TMP-ADDVN------------------------------ -G-HV-----------------TT--LG-------------------------------- -----LIWRPRADTFSIKVHIPETIHHLSKRF---------------------------- ----------------------------------------------------------IA SRPFSISGIDYCGPVF-------------------------------------------- ----------------------------VKGA--HRRA---VPT------KA-FVA---I -FICFT--TKAVHIELVSNLTTEAF-----LAALRRF-IGRR-GLVSELHSDNGTNFKGA SNELN-N-------LYRLLHSD-EH------------------QRKMH---SWTLERGID ----WTFIPPRAPHFGGLWESAVKSAKYHLLRTMG--T-----SSY----TFEDM----- --MTI-----LTEVEGCLNSRP--------ITP------------M-------------- ----------------------SD--------NPS--D-------L-------------- ----------- >151/1-550 ---PTKREALQVLMSIFDPLGLLSCYTIGLKMLLQK-VWRA-G----------I------ -DWDE-E-LPD--ALFTSWQQWKTVLLQAT---E-LEFP--RFY--S------------- -TLLPNA---DQI-DLHT-FVDASEY-AYA-AVTYLR--IKR--GA------DVDT-V-- LVAA---------------------------KCKV-APL--K-P---------------- --------------------------------VSIPRMELLAAV-IGV-GLAKKAMNV-- -R------R-LNI---NSS---TY---------WT------------------------- -------------------------------------WYLPIFIA-------LNPN-K-X XKI-RLVWDAAAK-S-HG---KPLNDFMXNGPDXX--NPLTEVLMAFR---VGRI--GVX ADIAKMFHQITXQQS--DMHVXR-----F------LXLSX---XN-----------KTPR TFVMRAXTFGIXCAPCIAXYV-RDKN------------A----QEF-KDQC--P-RAFES I-TKA--HYVDDL-IDSYT-D---DSEAIAVTSXVR-DI-HAEG-------GFTIR-NWI SNST-AI-LKHF---G----------EXQXAE-----------------------QHPKE LGGPE-----------------KV--XG-------------------------------- -----MYW---------------------------------------------------- ----------------------------------------------------------CF ERPFTYTGVDYFGPIL-------------------------------------------- ----------------------------VN--VG-R-----H-KE-----KR-WGV---L -FTCLT--LRAVHIEVAHKLDVSSC-----IMCLRNF-MTRR-GTPKEIFSDNGTNFKAT EKMVK-E-------ELQKIDFD-E----------------------IT---IKY--EAIK ----WHFNPPAAPHMGGAWERLVRSVKTVLKAICP------T-NNF----NDETL----- --QTA-----LMEAESIINSRP--------LTF------------V-------------- ----------------------SL-------------DSADDEALTPNHL---------- ----------- >1510/1-540 ---PTKREVLRTLMATFDPLGLISNILIYLKILFQE-ICRT-G----------I------ -EWDE-I-IPD--NLHEKWERWLEILPKVQ---E-VRIP--RCY--R------------- -VNTELG-PRTNV-QLHT-FVDVSMS-GYS-AVVYLR--FEQ--GS------RVEC-A-- IVGA---------------------------KTRV-SPL--K-L---------------- --------------------------------VSIPRLELQAAV-IGV-RLADTVMKT-- -L------S-FPI---NQR---FF---------WS------------------------- -----------------------------------RVWYLPLFPV-------FNPN-K-P GKV-RIVWDAAAK-T-NG---ISLNSLLLKGPDFL--TPLDYVLYRFR---EFRV--GLS GDVREMYLQLLMSKE--DQQCLR-----V------LWRDE---P-SK---------E-PS IYVTQVMPFGTCCSPSCAQYV-KNLN------------A----SKF-EGQY--P-AAAQA I-TKQ--HYVDDM-LVSVE-T---EQEAIKLAKDVK-YV-HAQA-------GFDMR-NWI SNST-AV-VEAM--EE---KTKQ---EKSMNI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF ARPFSYVGIDYFGPMS-------------------------------------------- ----------------------------VV--VG-R-----R-IE-----KR-WGV---L -LTCLT--MRAVHIEIAYSLNADSC-----VMAIRNF-MARR-GVPIQIYSDRGTNFTAA KKELA-AANEELIVALKELNQD-K----------------------VV---AEIVSTDTD ----WTFLPPASPHMGGAWERLIQTVKRNLQAMKP------G-RNP----SDEVL----- --RNT-----LMEIENIVNSHP--------LTY------------V-------------- ----------------------PI-------------ED--------------------- ----------- >1514/1-557 ---PTKREVLRTLMMIFDPLGLIGNFLMYLKTVLQE-IWRT-S----------V------ -GWDE-P-IED--KQYEMWIEWLNVLPSVA---N-VEIP--RCY--R------------- -TATSTG-NSNNV-QLHI-FVDASEK-GFA-AVAYLR--FQE--GQ------IIET-A-- LVGS---------------------------KTRV-API--K-F---------------- --------------------------------LSIPRSELQACV-IGV-RFANSIMKS-- -L------T-INV---NRR---YF---------WT------------------------- -----------------------------------REWYLPVFPV-------LNPN-K-P GKI-RLVWDAAAS-A-YG---VSLNSLLLKGPDLL--TSLLSVLIQFR---QFRV--AVC GDIREMYLQVLLKQD--IRLC-------F------FWKDD---E-ND---------QTPS VYTMSVLPFGVSCAPSIAQFV-KNTN------------A----ERF-AEEH--P-AAVHA I-IDQ--HYVDDM-LVSVE-S---EKEAVITAKDVK-RI-HADA-------GFEMR-NWI SNCP-QV-LEAL--GE---PKTA---EKDLNM-----------------------AEG-L VT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF ARPFTYMGVDYFGPYV-------------------------------------------- ----------------------------IQ--LG-R-----R-LE-----KR-WVL---L -ATCLT--TRAIHLQVVHSMTTDSC-----IMALRNV-MARR-GVPAMIFSDRGTNFQGA SKELE-E-------AIKNLDQT-R----------------------FE---TEFTTSHTQ ----WRFIPPASPHMGGAWERLVRIVKQNLAKLKP------N-RTM----SHEVL----- --ENL-----LTEIENVVNSRP--------MTN------------L-------------- ----------------------PL-------------DDDQSPVLTPNHF---------- ----------- >1515/1-533 ---MTKRELLSLIHSIFDPLGLIGPTLLPAKLLYQK-VCA-RN----------I------ -NWND-K-LEE--NELNEINQIIDGWVE-Q---E-FSRP--RKI--A------------- ----HGCDNNETL-QMHC-FADSSMK-AYA-VNIYLR--ITCPHK--------TNT-S-- LIFA---------------------------KNRI-VPK--G----KEKT---------- --------------------------------LTIPRLELLAIL-IGT-RAISFVTNE-- -L------K-QPIE---KT---IL---------WS------------------------- ----------------------------------------------------------SF TKL-RVVFDAGS----GK---TPLNNELLRGAVLL--PQLPGILIRTL---MFNN--LLI ADIAKAFLQIQLRPE--DRDVTR-----F------LWVKD---I-KH----QPEYTNL-I SYRFTRVLFGVISSPFLLIAT-ILHH------------L------EKIKS---P-LS-EE I-KTN--LYMDNI-ILGAK-N---INEIKEKYKELI-QI-FNRA-------KMRVR-EFC CNSV-EG-NNMFEENDKHPSI--------------------------------------- ESKSL-----------------KF--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------TP SRVFQNTGLDFMGPII-------------------------------------------- ----------------------------VKDI-DEERS------------KR-WIL---L -LTCLS--TRTIHLEVVTSISTHAF-----LNAFRKF-VARR-TRPDYILSDNGSSFKLA EKTLK-R--------------I-KP---DQII-----------GEGLQ---KYFAKENIN ----WKFITPLAPWEGGVYERINGMIKSNIRKSIG--R-----KIL----DNDDF----- --NTL-----ICEVEAIINCRP--------LIQ------------I-------------- ----------------------DD--------EPE--T-------I-------------- ----------- >1517/1-536 ----TKQLILSIIATFFDPLGLLGASLVLLKMFMQK-LWTL-Q----------R-VDGTR YDWKD-P-LPP--TVGEEWRKLSXHLDVLT---N-IRIP--RCT--V------------- --IK-G-AV--DI-QIHC-YTDASEK-VYG-ACVYIR--SKNV-ER------KLAR-R-- LLTS---------------------------KSKV-APL-------K------------- ---Q----------------------------QPLPRLELNGSD-LGA-DLVEWVIRV-- -F-G----K-R-----FPV----------------------------------------- ------------------------------PANDSPRCFLPHHPV-------VREE-STT TKV-RVVFDASAKTS-TG---LSLNDVLLVGPTIQ--PDLRDIVLRSR---MRQV--MVV SDVEKMFRQIDMAPE--DSPYQS-----I------LYRFN---P-EE---------EI-A TYELTTVTYGTKPAPFLATRT-LKQL------------A----QDE-QQRF--P-LAAQA L-ETD--VYMDDV-ISGAD-D---VATATELRAQLD-SL-LGSG-------GFKLR-KWA SNEP-SV-LHGVAR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TV SRPFSQTGVDYFGPVY-------------------------------------------- ----------------------------VKAG--RGRQ---P-T------KA-YVA---L -FVCMA--TKAVHMELVTDLSTECF-----LQALRRF-FSRR-NRPTDIYSDNGTNFVGA KNVLE-Q-------LLKQLKDV-KH------------------HEKIA---RVCEFEGIR ----WHFNPPSAPHFGGLWEAAVRSAKHHLLRVLG--E-----NSA----SFEDY----- --NTL-----LTQVEACMNSRP--------LTA------------L-------------- ----------------------SN--------DPT--D-------L-------------- ----------- >1518/1-557 ---PTKRIALRVIMSIFDPLGVLAPMLIHGRLLMQD-LWRA-H----------I------ -NWDE-Q-MSD--EEFVKWTKWAATLPNIF---E-LKIP--RWY--F------------- -KGTGSI-PQEPM-QLHV-FTDASEQ-AYG-CVAYFR--VNDG-GK-------IRC-A-- LVMS---------------------------RSKV-APL--K-H---------------- --------------------------------LSVPRLELQAAL-LGA-KLMKTVCEN-- -H------D-YNV---SER---YI---------HT------------------------- -------------------------------------WYLPLNIV-------SHPK-K-P TKK-RLVWDAAAK-V-GG---MSLNSQLLKGPDLL--VMLPQVLCTFR---QRRI--AFG GDIEKMFHQIRIKKE--DTHSQR-----F------LFRFE---K-DQ---------D-PK TYLMDVATFGATCSPCSAQYI-MHRN------------A----DEC-ANEY--P-IAAAA I-KRS--TYMDDY-FDSCD-T---REEAIERAKQVR-LI-HSQA-------GFNMR-NWV CNDP-IV-LEHL--EE-----RKTNQNPIVFK-----------------------TTTDD CQ--T-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PF LRPFTNVGVDYLGPID-------------------------------------------- ----------------------------IT--NL-R-----R-NE-----KR-YVA---V -FTCLV--TRAVHLEVAYSLSTESC-----IMAIRRF-VCRR-GPPTEIFSDNGTNFQGA SNELK-R-Q------LKE-VTL-T----------------------CA---ATFTDTHTK ----WSFNPPSAPHMGGVWERIVRSVKEGLNA-LD--D---G-RRL----NDEIL----- --ITA-----LTDVENLINSRP--------LTY------------M----PQTSADNEAL TPN----------------------------------HF--------------------- ----------- >1519/1-539 ----TKRSLVSDIAKTFDVLGWFAPTIIKAKMLFQR-LWEL-K----------V------ -DWDE-T-VPS--SILETWLRWRDELHLLF---K-VPIP--R-Y--Y------------- -FSKECH--ITSV-QIHG-FSDASKH-AYA-GVVYIR--GIDT-QG------NIHV-A-- LVTS---------------------------KTKV-API--K-Q---------------- --------------------------------LTIPRLELCGAQ-LLA-QLLGHVREV-- -L------Q-LSL---KDT---FG---------WT------------------------- -----------------------------------EVFYLPMHTV-------RKE-TSTT TKI-RAVFDASAKSS-TG---VSLNDTLLVGPTVH--PPLIDVLLRFR---SHRV--ALV ADVSRMYRAVRLTDT--DRDYHR-----F------VWRES---P-KD---------PL-K DYRMTRVTFGVSASSFMANMC-VKQN------------A-----VNHALTH--P-HASKV V-ENS--FYVDDA-LTGAD-S---TEKAIELQRELQ-DL-FSQA-------GFLLR-KWN SSER-EV-LQH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SP DIVFDKVGIDYAGPIS-------------------------------------------- ----------------------------VKYG--YVRK---PTIV-----KA-YVC---V -FVSLS--VKAVHLEPVSDLTTEAF-----IATLRRF-ISRR-GKPSVIWSDHGTNFVGA ATELK-D-------LFHFLSQH-NS------------------QQLIS---QFCSNQNIQ ----WDFMPERAPHFGGLWEAAVKSFKSHLKKVTV--N-----IKL----TFEEL----- --TTI-----LTQIEACLNSRP--------LTR------------I-------------- ----------------------NC--------NDD--G-------IEALTPGHF------ ----------- >152/1-558 ---ATKRIIYSEVAKHFDPLGLFSPSILVAKLLVQR-LWQC-K----------L------ -DWDE-P-VDA--RTQLEWNELKDALPKLL---L-IKIP--RQV--T------------- --FH-G-AI--YY-ELHG-FADASNV-AYG-ACVYIQ--STLE-DG------SVKS-R-- LLIS---------------------------KSKV-API-------H------------- ---P----------------------------LTIPRKELCAAL-LLV-RLVCKVLPA-- -L-T----I-P-I---RRV---NL---------YS------------------------- ------------------------------KP-----YYLPHHAV-------LRPG-SSS TKC-RVVFDASAKSAPTN---LSLNEALLVGPVVQ--SDILSIMIRFR---QHRY--VFT ADIKKMYRQIVVHPD--DTHKQR-----I------YWREH---P-NE---------AL-K ILELMTVTYGTASAPFQATRS-LIQL------------A----NDE-AENF--P-VAAEI I-KFD--CYVDDV-LSGTA-T---IDEAIEAQRQLK-EM-LARG-------GFPIH-KWC SNAP-QL-LALIPEDERESLK------PLA---------------------------DRH VNEVI-----------------KV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TP SPAFNITGVDYAGPIL-------------------------------------------- ----------------------------VK--QGTHRA---KVV------KA-YIA---V -FVCMA--TKAIHLELVSDLTTDAF-----LAALQRF-VSRR-GIVSEMHSDNATNFHGT NNELH-K-------LYEMFRNQ-PD------------------IDRIL---QFCHVKEIE ----WHFIPPDSPEFGGLWEAAVKCTKTHLKRVIG--D-----KTL----NFEEM----- --ATI-----LCEIEAVLNSRP--------LFA------------I-------------- ----------------------SG--------DPA--D-------P-------------- ----------- >1525/1-532 ----TRSTISGAIASNFDPLGLMVPLLLPAKLYQRDNLWNS-K----------------- YDWKT-T-ISP--EDQAKWAQVAENINGFT-----RELP--RNV--V------------- -DKTGTN-------KLIT-FCDASKD-AAA-FCIYAH-------DG-------SKT-H-- IVFG---------------------------KSKI-WPLKEP------------------ --------------------------------WTIPKLETHALM-MGT-TKTLGIYKA-- -LKVDNIAV-------DEV---II---------LT------------------------- -------------------------------------RYNPIQAV-------ITP-HKTT TKC-RVVVDGSSRTK-NS---VSLNDIIKKGPVIL--PDMVDMLIRFR---AGKT--VIV SDVEKAFLQVFLHED--DRDLTR-----V------LWLKD---Y-TK----PPTRDNL-V CYRFTRVLFGLNVSPFLLAAV-IHYH------------L------RSVDNQ--I-LA-KQ L-PYS--LYVDNL-ILTTDAS---TEEAHNTYRQVK-GI-FSDM-------HMNIR-EFL SNSP-HL-NEMIEEKDR--A---------------------------------------- SSQSM-----------------KV--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------KR SRPFANTGLDNFGPIP-------------------------------------------- ----------------------------YVKE-DGTEG------------TA-MGT---I -FTCSC--TRLLHIELAKDASALEF-----LNALRRF-VAIR-GLPELIVSDNGTNFVLS QKIIE-E---------AF--K-------IYDP-----------TKQ---------LHDIK ----WKFNTPLSPWKGGFYERMVKSVKGPLYKAMG--R-----KKL----TYEEL----- --KTI-----LYEIMSAVNSRP--------LTY------------P-------------- ----------------------EQ--------D--------------------------- ----------- >1526/1-559 ----TRRGILSVISSIYDPLGILSPVVLTAKIILQQ-LCRK-E----------L------ -GWDE-P-IPP--SAAQEWTQWLEELSQLE---D-FQIP--RCL--K------------- -PLDFGE--VIAA-QLHH-FTDASED-GYG-VVTYLL--SQNA-QS------LVHS-A-- FVMG---------------------------KSRV-APL--K-S---------------- --------------------------------VSIPRMELTAAT-MAS-RMDTFLKRE-- -L------H-MRL---QPS---LF---------WT------------------------- ---------------A---------------REDGRLWYIPHHGV-------YHPR-K-- GTM-RVVFDCGAP-F-QM---TSLNDQLLQGPDLT--SSLISVVTRFR---KEPV--IIL ADIESMFHQVRVPAE--DMDLLR-----F------LWWPD---GDFV---------QELA DFRMKVHLFGATSSPSCANFA-LRKC------------A----EDN-EGQF--SREAIEK V-LHC--FYVDDC-LVATA-T---EKEAVALQHDLV-SI-CSKG-------GFKLT-KWT SNRH-AV-ITAI-------PEDQRAKDMKDLD-----------------------LEQDT -LPVE-----------------RV--LG-------------------------------- -----VQF---------------------------------------------------- ----------------------------------------------------------PE EAPFTRVGVDFFGPFA-------------------------------------------- ----------------------------VK--SR-R-----S-MV-----KR-YGV---L -FTCLT--IRAIHIEVASCLDTSAF-----INALRRF-VARR-GQVQEIRSDNGTNFVGA ERELR-E-------AIEVWNHA-Q----------------------IN---DILLQKGIK ----WNFNPPTGSHHGGVWERLIRSIRKVLNSTFK--V---Q--NL----DEDGF----- --HTV-----LCEVESIINGRP--------LTN------------S-------------- ----------------------SP-------------D--------PNDL---------- ----------- >1527/1-611 ---PTKRQIMSDVARLFDPLEYLGPTVVIAKLVMQQ-LWKE-K----------V------ -GWDD-P-TTA--EVMETWERFRSELCEIS---G-LKIP--RRV--T------------- --VN-G-TM--SY-EIHG-FADASMK-AYG-CCIYLR--CLKS-DD------TAEM-S-- LLCS---------------------------KSRV-APV-------K------------- ---ELNREWKGDEKPEE---------------MTIPRLELCAAK-LXV-EQAVKVLNA-- -I-Q----L-D-V---RRT---VL---------WT------------------------- -------------------------------------FYLPHHCV-------LKPD-NST TKL-RVVFDASARSS-TN---LSLNDIMMIGPTVQ--RSLFDIVLRFR---CHRY--VFT ADVQKMYRQVMVHED--DQKYQR-----I------VWRDN---R-EQ---------EL-K TIQLSTVTYGTAAAPFLATRS-LNQL------------T----LDE-QSDF--P-EASDA V-LNG--FYVDDA-LAGAD-G---LDQTQKLQGDLI-EM-LDRG-------GFQLH-KWC ANDS-AL-LQKIPVEARAKEL------DFE---------------------------TCK EGESV-----------------KT--LG-------------------------------- -----LLWNPVNDVFMFRVSPFKMSSQLPTKRQIMSDVARLFDPLEYLGPTV-------- ----------------------------------------------------------TE ALPFSRTGVDYAGPLL-------------------------------------------- ----------------------------LK--QGRMKS---P-V------KA-YIA---L -FVCMT--TKALHLELVTSLSTESF-----LAALHRF-VGRR-GNVSEMRSDQGTNFVGE DHQLK-E-------FYDMLTSQ-LM------------------QKKIA---EFCQVRCID ----WKFNPPKAPHQGGLWEAGVKCVKYHLHRVLK--E-----AYL----NYEEM----- --NTL-----LVQIEAILNSRP--------LCQ------------Q-------------- ----------------------SD--------DPC--D-------Y-------------- ----------- >1528/1-533 ----TKRNTLKTIASNYDPLGFIAPTTVKGKLFFQK-LCF-DH----------H------ -VWDT-P-LSQ--ELHPLWNDITESWKG-D---A-LRIP--RQF--F------------- --TQDDLDRTLMI-ELHV-FTDASQH-AFG-AVAYLR--LLLENNT-------SKC-C-- FVMS---------------------------KNRI-APL--R------PQ---------- --------------------------------HSIPQLEMVGVL-TGV-RLGKYIEKE-- -L------D-FVID---QK---YL---------WS------------------------- -------------------------------------HYLAHHPV-------FKE-SSSS TKV-RIVFDGSAKHK-RS--NRSLNDSLYTGERLL--PEIAGVLLRAR---KPHI--LIS ADIQKAFLQLGLQVC--DRDATR-----F------LWI-------------D-STGKI-I CYRYQRVPFGLKSSPYLLNAT-IREH------------L-------KKSDH--Q-FA-KD M-QRS--IYVDNV-YVGVP-N---VEQAKEFYNISK-QI-FREA-------NMNLC-QFT SNSL-EA-NQFF-EAQ-EKSS--------------------------------------- EPTEM-----------------KL--LG-------------------------------- -----VQW---------------------------------------------------- ----------------------------------------------------------LT SRPFEHVGTDYAGPFN-------------------------------------------- ----------------------------VLTTPQQS--------------SSCWFI---L -FTCLY--SRYTVVKVVLNMEAESF-----LHALRQL-AAMF-GTPKNIVCDNGSQLAMM KKVME---------IIS--TRNPQ---------------------------QLLNSTNLP ---TFKYIPAHSPWAGGIYERVIGLIKESLRKIGI------QRQLL----TLQDF----- --ETI-----LIECTAVINLRP--------ISY------------V-------------- ----------------------S------------------------------------- ----------- >153/1-559 ----TKRIVVSEMSQLFDPLGLLGPVVVNAKMFIQS-LWAA-N----------L------ -SWDS-E-LAE--ESATWWRNYRADIKQLQ---Q-LVVP--RRV--L------------- --WN----TKHKY-SIHC-FCDASQK-GYG-CCVYIV--SPDE-LG------QLHS-H-- LLTS---------------------------KSRV-APL-------R------------- ---G----------------------------QSIPRLELCAAL-LGS-QLVDNLLAN-- -T-N----I-D-----ASV---TF---------WT------------------------- ------------------------------VASRNPQFFLPHHAI-------QRPE-SST TKT-RVVFDGSCRGA-AS---LSLNEALYVGPTVQ--PALFSTVVNFR---LPRF--VIT ADAEKMFRQIWVHPD--DRKFQQ-----I------LWRGS---S-TE---------PI-R TYQLKTVTYGLASSPFHAARV-LIQL------------A----NDE-GHRF--P-LAVPV I-LKG--TYVDDV-ITGHD-D---HDKMAETCKQLS-EM-MKSG-------GFVLR-KWA SNYK-TV-LIHIPEELWETSA------ELE----------------------------LD RSEAI-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------RP ARAFTYAGMDYCGPFY-------------------------------------------- ----------------------------VRPL--IGKG---TSV------KV-YVA---L -FVCLV--VKAVHLEVVPDLSSVAC-----IAAVKRF-VARR-GRVLELHCDNATTFVGA DRELR-Q-------LRKEFQLQ-FK------------------SPEWG---DYCSGNGIT ----FRFIPARSPHFGGIWEAGVKSFKYHFRRIMG--Q-----KAF----SMDQL----- --LTV-----IAQIESVLNSRP--------LVP------------I-------------- ----------------------SD--------SPD--D-------L-------------- ----------- >1531/1-545 ----TRRTVLKTVASFFDPLGLCSPCLVGAKLFFQK-LWD-GS----------K------ -GWDD-P-IPA--EETKEWDEIKALWAA-K---T-MHIA--RFT--P------------- ----R-INTGG-I-QLHV-FTDASPN-AFA-CTVYLR--AEMPQG--------ILS-S-- LAYA---------------------------RSRL-RPK--KMAVDQADG---------- --------------------------------LTIPRLELLGIL-IGS-RAVKFVHKH-- -L------N-YEIE---QI---NL---------WS------------------------- ------------------------------HRAKSPQHFLPHHTV-------MGK----- -KL-RIVFDASSHEK-GA---QSLNEMLFSGPNLY--PDLAGKLIQFR---ATKY--PIW ADIEKAFLMVSLKES--DREFSK-----F------LWVKN---I-FA----PLSGENL-L VFRFRRITFGIVSCPFLLAAT-LQHH------------L------EAFPS---E-LA-EE I-REKSLLYVDNL-LLLAD-S---PEEARRKAAEAQ-KI-FAAA-------QMRLC-EFI AADP-SS-LDEIPENDR--L---------------------------------------- RNEAP-----------------TV--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------CP SAVFENVGMDFLGPTL-------------------------------------------- ----------------------------YKIP-NEQPA------------KA-WVL---L -ITSLA--CRAVHLELVSSMSAEHF-----LLAFRRF-VARR-GLPKSILSDHGSQFVLA KTLFE-K--------------N--T---EV---------------------------SIK ----WTLIPAFSPWSGGVYERLNSLIKNCFRRVLG--R-----RLL----SWEEI----- --NTF-----LAEAEASINSRP--------ITF------------V-------------- ----------------------SD--------ESD--G-------PLPLRPIDF------ ----------- >1533/1-580 ---PTKREVLRTLMLVYDPLGLVGNFLMFMKILLQE-IWRA-G----------Y------ -SWDQ-Q-IDR--DCAEKWLKWISALPSLQ---S-VRIP--RCY--R------------- -VKTSAT--VRNV-QLHI-FCDASEN-GMA-AVAYFR--FEE--DN------TIEC-S-- LIGS---------------------------KTRV-SPL--K-F---------------- --------------------------------LSIPRLELQATV-IGV-RLATSIVKY-- -H------R-MKI---TRR---IF---------WT------------------------- -----------------------------------RDWYLPIFPV-------INQN-K-P GKL-RMVFDAAAK-V-HG---VSLNTFLLSGPDQL--AELMSVLHKFR---EFRV--AVA GDIREMFFQINMKKE--DQRSQL-----I------FWDEK---ETYN---------AEPT TYAVTVMTFGATCSPGTAHFV-KNNN------------A----ERF-AEQF--P-RAVHC I-KYE--HYVDDM-LASAE-T---SEEAAQLAETVR-HI-HAEG-------GFEIR-NWV SNSN-EV-LERL--RW---GVSQ---EDGRGV-----------------------VMD-S SA--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------VG QCAFTYTGLDYFGPML-------------------------------------------- ----------------------------VV--VG-R-----R-TE-----KR-WGV---I -FTCLT--TRAIHLELAHSLNTTSC-----ILAIRRF-VARR-GPPREIISDRGTNFIGA SRELK-E-------AVSEVNED-E----------------------LI---CEFSTSTFR ----WTFNPPAAPHFGGCWERLVRSVKQILCKFNL------P-RLP----SDEVL----- --QST-----LAEVEMIINSRP--------LTY------------V-------------- ----------------------PL-------------NDEMDMPITPNHLLLGSSDGTKR SVPFDDSPAAV >1537/1-558 ----TMRTIYKILASQYDPLGFLTPYLTRAKVLVQQ-LWAK-R----------R------ -DWDD-PDLPL--DLCESWKQWESELPNIS---A-ISIP--RSY--L------------- -PDGMDQ-PNTEH-HLHV-FCDASEK-AYG-AVAYL---SSTQ-GG------ATNV-A-- FVMA---------------------------RSKV-APK--R-Q---------------- --------------------------------QTMPRLELCAAL-AGA-QLANLIQTE-- -L------S-VTL---QRT---TL---------WT------------------------- -----------------------------------ESWYLPHHLV-------YHN----- DKA-RLVFNCSHV-Y-KG---TSLNDQLLPGPNLG--PSLIGVLLRFR---QHQV--AIS GDIRGMFHQVHLLPE--DTPLLR-----F------LW-RD---LQQE---------ASPE IYEWQVLPFGTTSSPCCAIYA-LQRH------------V----REH-PRS---TPGLIES V-ERS--FYVDNC-LESHP-N---GAAAQARVDDLR-SL-LADG-------GFDIR-QWA SNRL-SV-VAHL-------PPEARSKDMELWL-----------------------EHNRS -DQRE-----------------PA--LG-------------------------------- -----LCWNCSSDTLGYRY----------------------------------------- ----------------------------------------------------------IF SPPFHSTGIDCYGPFI-------------------------------------------- ----------------------------AK--IG-R-----R-HE-----KR-WGV---I -FKCLT--TRAVHLDLLNSMDTDAF-----LLALRRF-IARR-GRPVEILSDRGTNFRGA DAELR-A-------AFEEMETQ------------------------LQ---QQLASYQIE ----FKFNPPNAPHFGGVWEREIRSIKNALQVAVG--T---Q--PL----PEDVL----- --HTI-----LVEVEGIINSKP--------LGY------------V-------------- ----------------------SA-------------DI--------------------- ----------- >154/1-559 ----TKRKVISYIAKIFDPLGLVGPAIATAKLFMQR-LWKL-K----------H-EDKSP YEWDR-P-LPD--KLQDEWKQFHATLPILA---E-IKIS--RFV--S------------- --LP-D-VS--KT-ELHF-FSDASEV-AYG-ACCYVR--TLN--AE------EVKV-Q-- LLTS---------------------------KSKV-APL-------A------------- ---TK---------------------------HTIARLELCAAV-LST-KLYHKVQQS-- -I-K----T-P-----AEV---FF---------WT------------------------- -------------------------------------CYLPHHPV-------FKES-STT TKV-RVVFDASCKTS-SG---MSLNDTLLVGPVVQ--QNLDSIIIRFR---FHAV--AIV ADVEKMYRQILHSPD--DQRFLR-----V------LFRRR---P-SD---------PL-D TYELLTVTYGTASAPFLATRT-LQQL------------A----KDE-GHNY--P-EAEEA V-VED--FYVDDV-LTGAN-N---LESALEKRRQLS-AM-LASA-------GFPLK-KWA SNVP-EA-LADIPPEDLAIKP--L-H-DLQ---------------------------D-- -DQSV-----------------ST--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------TP ARPFAISGVDYCGPVF-------------------------------------------- ----------------------------IKSP--IRNR---APT------KA-YIG---I -FVCFA--TRAVHIELITDLSTPAF-----LSALRRF-VARR-GLVREIHSDNGTAFKGA ANTLH-R-------IYEMLKSS-DAD-----------------RNQIQ---TWCAERQIQ ----WKFIPPRAPHFGGLWEAAVKSAKHHLLREIG--N-----ISL----PYEDM----- --VTL-----LAQIEMCLNSRP--------LTP------------I-------------- ----------------------PS--------DPA--D-------L-------------- ----------- >1540/1-549 -----KRSLLSTAFRVFDLVGCLAPFTVRAKMFLQT-LWQR-G----------T------ -SWDE-P-LPH--DVMEQWRRWKQELPHLS---R-IRLP--RAL--V------------- -PVALGQ--VTRL-EIHA-FCDASEK-AYG-AVAYMR--IETT-NH------HTVV-N-- FVTS---------------------------KTRV-API--R-R---------------- --------------------------------LTLPRLELMGAL-VAA-RLVRSVQKM-- -L------G-LQV---HGI---TC---------WC------------------------- ------------------------------IGPEGRTWYLPHHAV-------YQG-EGKE KKC-RVVFDGSAQYG-QT----SLNRQLEVGPNLQ--IDLLKALLRFR---RYRV--GLQ ADIQKMYLQVRIAEQ--DRDACR-----F------LW--R---D-KS--------GEL-S HLRLQRVCFGLTCSPFLAINT-VRVH------------A----RRHQDAGP--R-AA-AE I-LEN--MYVDDL-ATSCD-T---IEEARELAGELR-GL-LAKG-------GFHLH-KWA SNEP-EA-LTSVPDEVRSASN--------------------------------------- RSHLW-----------------KT--LG-------------------------------- -----MQW---------------------------------------------------- ----------------------------------------------------------VE AAAFAHTGIDFAGPLL-------------------------------------------- ----------------------------IRV-GKR-A-----TS------KC-YVC---L -FTCMA--SRAVHLELVPQMTTARV-----MQALRRF-IARR-GRPEIIQSDNFRSFKAA ASELR-Q-------LWRHVD-----------------------VDRVQ---RELVGHRIH ----WKFITERAPWMGGYWERLVRSIKESLRKILG--K-----ALL----DEEEL----- --RTT-----LCEVEASLNARP--------LTF------------V-------------- ----------------------GD-------------------------EDHER------ ----------- >1541/1-555 ---PTKRMVLRIIMSLFDPLGLLAPVLILGRIVMQD-LWRS-G----------M------ -DWDA-E-VQE--QDYQKWQNWVNLLPGIH---A-LSIP--RWY--L------------- -GSNVEK-QPESV-QLHV-FSDASEQ-AYG-CAAYFR--FDMG-SE-------IHC-S-- LVMA---------------------------RSKV-APL--K-H---------------- --------------------------------QSIPRLELEAAL-LGA-RLARTVCES-- -H------D-IKV---SEK---FL---------HT------------------------- -------------------------------------WYLPLNIV-------GHPR-K-P DKK-RLVWDAAAK-V-KG---VSLNTQLLKGPDLL--VALPSVLCRFR---QRKV--AFG GDIEKMFHQIQIKKE--DTHAQR-----F------LFRFN---P-QE---------H-PQ TYLMDVATFGAACSPCSAQYI-MHRN------------A----DEH-AEQY--P-EAAAA I-KKN--TYMDDY-FDSCD-T---VSEARQRSMQVK-LI-HSKA-------GFNMR-NWL SNED-AV-LESL--SE-----GPREQQRVI-D-----------------------FGQEE KY--P-----------------RV--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------TH VRAFSNTGIDYLGPLD-------------------------------------------- ----------------------------VV--NG-R-----R-KE-----KR-YVA---V -FTCLV--TRAVHLEVAHSLSTTAC-----IMAIRRF-IGRR-GPPAEIWSDNGTNFIGA SNELK-R-Q------LAN-THH-S----------------------CA---DTFTNANTR ----WNFNPPSAPHMGGVWERMVRSVKEGMSA-LD--D---G-RTI----NDETL----- --LTT-----LAEVEFLINTRP--------LVY------------Q----PQV-SDSEAL TPN----------------------------------HF--------------------- ----------- >1542/1-531 ---PTKRQILQCVMTLFDPLGLLAPYLIFGRILIQD-VWRA-G----------I------ -GWDE-L-VDD--NIFKAWQKWINMIGDID---H-VQIP--RCY--F------------- -RYPDSR-SLANI-QLHI-FVDASPL-AYS-CACYFR--IINA-MG------NIEV-A-- LVAA---------------------------KAKV-SPL--K-P---------------- --------------------------------MSIPRLELQACV-LGT-RMLKLVVDG-- -H------T-LHV---ARR---YL---------WT------------------------- -------------------------------------WFLPLGAV-------VNPK-K-P TKV-RLIWDASAK-V-DG---ISLNSMLLRGPDQL--SSLPSVVFRFR---QHKV--AVV GDIKEMFHQICISKS--DRYAQC-----F------LWKTG---A-SQ---------E-PD IMVMDVATFGATSSPATAQFV-KNTN------------A----MRF-AGTL--P-RAVDG I-IHS--HYVDDY-LDSFP-D---EEQAKQVATEVR-EI-HRTG-------GFEIR-NWG SNSK-IV-LEHL--GN-----GQEEAIKSLNL-----------------------EN--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY ARPFSYTGVDYFGPIL-------------------------------------------- ----------------------------VK--VG-R-----S-HA-----KR-WVA---L -YTCLT--VRAIHVELVHSLTTEAF-----VMSLRRF-VSRR-GAPIEIYSDNATNFHGA ERILR-E-Q----------IYA-G----------------------LA---ATFTNTTTA ----WHFIPPGAPHMGGSWERMVRSVKSAISSA-Y--G---N-DKL----DDEAL----- --QTL-----LIEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >1543/1-545 ---PTKRQVLRTLMMVFDPMGFIAHILMFLKVLLQE-IWRT-P----------V------ -GWDD-P-IED--AQFDKWLTWLTIFPKIE---S-VEVA--RCY--R------------- -LSTSMS---ASV-EMHT-FVDASES-GFA-AVVYLR--FKE--GS------VIEC-A-- LAGA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQAAL-LGV-RLADTIVKS-- -L------S-INI---DQR---YF---------WT------------------------- -----------------------------------RIWYLPIFVV-------TNPN-K-P GKL-RLVWDAAAT-A-HG---VSLNSFLLKGPDQL--TSLLSVLIRFR---EFRV--AVC GDIKEMFHQVQMRDV--DQQCQR-----F------FWRDD---G-N----------TEPS VYVVQVMTFGACCSPSIAQHV-KNSN------------A----KQF-EQDH--P-EAVDA I-VKR--HYVDDM-LVSTE-T---EEEAIRLAQDVK-NI-HMNA-------GFDIR-NWI SNSS-TV-QAAL--NE---VAAV---EKNMDI-----------------------SET-P AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF SRPFTYMGVDYFGPIL-------------------------------------------- ----------------------------VS--VG-R-----R-TE-----KR-WGV---L -ATCLT--TRAIHLQIVHTLTTSSC-----VMAIRNV-MARR-GTPAVIYSDRGTNFQAT SKELK-A-------AIQHLDHD-K----------------------LA---KEFTSSRTQ ----WTFIPPLTPHMGGAWERLIRTVKQNLVAMQH------S-RLP----TDEVL----- --HNA-----IVEVENIVNSRP--------LTD------------I-------------- ----------------------PL-------------DN--------------------- ----------- >1551/1-550 ----TRRTICSQIARLFDPLGIIAPVIVWAKILLQQ-LWIS-T----------T------ -SWDE-P-VNK--EIEIKWKSFVEQLSCMQ---C-IRVP--RFV--L------------- --LP-G-KC--KF-QLHC-FSDASER-AYG-ACLYVR--SVDD-SG------CVKV-S-- LVAA---------------------------KSKV-APL-------K------------- ---R----------------------------VSLAKLELCGAL-LAA-KLWKSVYRA-- -F-K----E-P-E---IPC---FF---------WT------------------------- ------------------------------------SCYLPHRPV-------VKES-SVS TKI-RPVFDGSAKTA-SG---YALNDLLLTGPVIQ--ESLFAIMLRFR---MHAI--ALS ADIEKMYLQVQVHPD--HTPLQR-----I------LWRSS---V-EM---------QP-K EYELQRVTFGLAPSSFLATRV-LQQL------------A----EDD-GARY--P-NAQRV L-RED--FYMDDL-LSGAN-S---FQEAKTLRAELS-EL-LSGG-------GFQLR-KWV SNVS-AV-LNDVPVENLSCPD--V-V-GLG---------------------------E-- -NVLV-----------------KT--L--------------------------------- ------------------------------------------------------------ ----------------------------------------------------------TP SRPFSFVGVDYCGPVF-------------------------------------------- ----------------------------LKPT--HRKA---AAL------KA-YIS---I -FVCFS--TKAVHIELVEDLSTGAF-----IAAFRRF-ISRR-GLPIHVYSDNGLNFQGA QKELL-E-------LFGMLKNK-SA------------------KAIVQ---SEAVKLGIT ----WSFIPPRSPNFGGLWEAAVKAAKRTMRKVLG--D-----RQL----SFGDF----- --VTV-----LTQIEAQLNSRP--------LTP------------L-------------- ----------------------SE--------DPC--E-------L-------------- ----------- >1553/1-571 ---PTKRIALSIIMSLFDPLGLLAPYLVHGRILVQD-LWRA-G----------M------ -NWDD-P-MGD--AEFTKWKRWIELISKIG---K-LKIP--RHY--F------------- -AGASIP-IEQKL-QLHI-FCDASES-GYG-CVAYFR--AELE-DG-------IHC-T-- LIMA---------------------------KSKV-APL--K-C---------------- --------------------------------QSIPRLELQAAL-LGA-RMMNSICEN-- -H------T-ITF---SRK---FI---------HT------------------------- -------------------------------------WYLPINVV-------AHPR-K-P EKK-RLVWDAAAR-V-DG---ISLNSQLLKGPDLL--ALLPGVLCKFR---QGCI--AFG GDIEKMFHQIRIREN--DKHAQR-----F------LFRFD---A-NS---------E-PD VYIMDVATFGAACSPCSAQFI-MQRN------------A----EEH-RSAW--P---AAA I-MKS--TYMDDY-LDSSD-T---VAEASSLALQVR-HI-HANA-------GFNMR-NWM SNHQ-EV-LEAL--GE-----SHDRREMNI-------------------------ECDTE PE--H-----------------RV--LG-------------------------------- -----VKW---------------------------------------------------- ----------------------------------------------------------PH VRPFSRVGIDYLGPIE-------------------------------------------- ----------------------------VS--VG-R-----T-KV-----KR-YVA---V -FTCLV--VRAIHLELVYDLSANAC-----IMAIRRF-VCRR-GPPLEIFSDNGTNFVGA SNELK-K-Q------LRE-INN-D----------------------CA---ETFTNTRTA ----WQFNPPAAPHMGGVWERLVRSVKEALTV-LQ--D---G-RKL----TDEIL----- --TTV-----LVESENLINSRP--------LTY------------V----PQSTSDNEAL TPNHFLLGSSSGSQDQAKT---PT-------------EL--------------------- ----------- >1554/1-554 ---PTKRQILQCVMTLFDPIGLLAPYLIFGRVLIQD-VWRA-G----------T------ -KWDE-Q-VDD--NIFQRWREWVKILQDID---Q-VRIP--RSY--F------------- -RYPNRL-SVNNI-QLHI-FVDASPA-AYS-CACYFR--IIND-RG------EAEV-A-- LVAA---------------------------KAKV-APL--K-M---------------- --------------------------------MSIPRLELQACV-LGV-RMMKLVIDG-- -H------T-FPI---KNR---FL---------WT------------------------- -------------------------------------WFLPLGVV-------VNPK-K-P SKI-RLIWDASAK-V-DG---VSLNSMLLKGPDQL--SSLPSVLFRFR---QHRV--AVV GDIKQMFHQILINHS--DRYAQC-----F------LWSPD---A-SK---------K-PD IFVMNVATFGSTSSPATAHFV-KNTN------------A----RRF-SKEF--P-RAVEG I-VYN--HYVDDY-LDSFP-D---EAEAKQVVEEVR-EI-HRRG-------GFEIR-NWC SNSS-AV-LEHL--GE-----NPDTVVKKLNA-----------------------DCGGL PDRVL-----------------GM--LW-------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PF TRPFTYVGVDYFGPIS-------------------------------------------- ----------------------------LK--RG-R-----N-CV-----KR-WVA---L -FTCLT--VRAIHVEVVYSLTTEAF-----IMSVRRF-VGRR-GAPAEIYSDNATNFHGA ERILR-Q-Q----------INT-G----------------------LA---ATFTNTCTT ----WKFIPPGAPHMGGSWERMVRSMKSALSVA-Y--C---D-EKL----DDEAY----- --QTL-----LVEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------LSTEQEALTPNHF---------- ----------- >1555/1-557 ---NTKRQLLSDSARLFDPLGWISPIIVRIKILYQT-LWLQ-D----------L------ -QWDD-P-LPA--AVNQEWNKIKQSLAAIE---D-IRIP--R-W--I------------- -ANHHGA--L----QLHG-IADASEA-AYA-AVVYAR--TVDD-EG------NVCI-S-- LVAS---------------------------KTKV-API--Q-Q---------------- --------------------------------VSLPRLELNAAV-LLV-ELMKQILEA-- -M------D-NLD---VTC---YA---------WT------------------------- ------------------------------NIEPEKRFYLPHHGV-------MRQD-SVT TKL-RVVFDGSCQSS-SG---ISLNEKLLIGPKVT--EDLPIVLTRFR---SYAF--AFM ADAEKMYRQVRIHRG--DVDYQR-----I------VWRTD---P-DK---------PI-E HYRLLTVTYGTSCAPFLAIES-LRQA------------A----RDS-CAQY--P-IASGR V-QIN--FYVDDF-LSGAA-T---LEGALTLKKDIV-RI-TSEA-------GFHLR-KWS ANDP-RL-LEGNASAADTSVPVHL-HPDAD------------------------------ ---SV-----------------KA--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------VS SRAFEIVGVDYAGPVT-------------------------------------------- ----------------------------IKAS--LLRS---TKTV-----KG-YIA---V -FVCLA--TKAVHLEAATDLSANTF-----ISALKRF-CARR-GLPNQLWSDNGTNFVGA DRQLK-E-------LLASAAFN-S---------------------EVD---QYLNSLGIQ ----WNFITPSAPHMGGLWEGAVKSMKKHLRVVLG--T-----TVL----NFEEL----- --TTV-----LTQIEACLNSRP--------LCT------------L-------------- ----------------------SS--------SVD--S---------------------- ----------- >1558/1-551 ---PTKRTALRIIMSLFDPLGLLAPILIHGRMIMQD-LWRA-K----------L------ -GWDE-E-MAD--AEFLKWQRWVDLIPLIY---K-IEIP--RCY--F------------- -GNTASK-AYKSL-QLHV-FTDASEL-GYG-CVAYFR--VEDE-HG-------VHC-S-- MVMA---------------------------RSKV-APL--K-H---------------- --------------------------------LTIPQMELQGAL-MGA-RLMSTVSEN-- -H------T-LPI---SKK---FL---------HT------------------------- ---------------G---------------ANPSRVWYLPLNVV-------GHPR-K-P DKK-RLVWDAAAK-V-NG---VSLNSFLLKGPDLL--VTLPSVLSQFR---ERRV--AFG GDIEKMFHQIKIREE--DKHAQR-----F------LFRTD---P-SQ---------P-PS VYIMDVATFGASCSPCSAQYV-MHRN------------A----QEN-ATEF--P-ESAAA I-KGK--TYINDY-FDSCD-T---EEEAIKRAQEVK-LI-HSKG-------GFNMR-NWV SNSQ-TV-LNSL---E-----NTSNQSVTI-K-----------------------YGDVE KQ--Q-----------------RV--LG-------------------------------- -----MAW---------------------------------------------------- ----------------------------------------------------------SY ARPFSYVGVDYLGPLD-------------------------------------------- ----------------------------VV--NA-R-----R-TE-----KR-YVA---V -FTCLV--TRAVHLEVAFSLSTDSC-----IMAVRRF-VSRR-GPPIEIFSDNGTNFVGA NNELK-R-E------IAA-LNS-K----------------------LA---DTFTNSRTN ----WNFNPPSAPHMGGVWERMVRSVKESMNA-FV--D---G-RKL----NDEIL----- --NTA-----LIDAECLINSRP--------LFY------------M----PHNT------ ------------------------------------------------------------ ----------- >1559/1-559 ----TKRIVASEMAQLFDPCGLIGSVVVWAKMFVQG-LWYE-K----------F------ -AWDQ-E-LPE--GLAKSWHTFRDQLPYLL---E-FRVP--RRV--V------------- --------VSRKF-MLHC-FCDASER-GYG-CSVYVV--SKDQHKS-----------YSN LLST---------------------------KSRV-APL--R-E---------------- --------------------------------HDITRLELCAFL-LGC-QLIDTILTTTE FV--------------APV---VF---------WT------------------------- ------------------------------E-----EFNLPHHAI-------RRPD-STT TKT-RVVFDASVKGC-NQ---LSLNEILHSGPTVQ--PTLLSTVLNFR---LPKY--VFI ADIEKMFRQIWIHPE--DRKLLK-----I------VWRTN---T-QS---------PL-E TYQLKTVTYGTACAPFQAARV-LNKL------------A----DDE-GHRY--P-LGAHI L-KNH--TYVDDT-LAGRD-S---LNEAIEATVQLR-QL-LQSG-------GFNLR-KWC SNDR-RV-LQQIPTDLVEMPH------EIE----------------------------ID RSNTI-----------------KT--LG-------------------------------- -----LFW---------------------------------------------------- ----------------------------------------------------------TP ARVFANCGLDYCGPFL-------------------------------------------- ----------------------------VRPL--IGRG---AAL------KM-YVA---C -FICMV--SKAIHLELVPDLSSQAC-----INAIKRL-IARR-GRLLTLHCDNATTFKGA DRELK-E-------LRNQYIAQ-FQ------------------TEMWN---NFCLAQGIT ----FHHIPPRSPHFGGLWEAGVKSFKHHFKRILG--N-----KSL----RLDEV----- --TTC-----VTQIEGILNSRP--------LTP------------L-------------- ----------------------TN--------DAD--D-------LSALTPGHL------ ----------- >156/1-541 ---PTKRIALRCIASMFDPKQFLAPLLIQGRIIMQD-VWRS-C----------I------ -GWDD-K-LTE--EHYERWKKWTSLFHLID---E-IRVP--RCY--L------------- -GGLESE-AYQTV-QLHV-FTDAGEK-AYG-CVAYFR--FENG-GV-------VQC-A-- FIEA---------------------------KAKV-APL--Q-Y---------------- --------------------------------LSIPRLELEAAI-LGA-RMMKSICEN-- -H------S-FPV---LKR---FL---------WC------------------------- -------------------------------------WYLPLNYV-------TNPK-K-P GKV-RLVWDAAAK-A-HG---VSFNDMLLKGPDMI--TSLPAVINGFR---EKRI--AFG GDIKEMFHQALVRPE--DRQAQR-----F------LFP-G---A-DG---------E-VE IYVMDVVIFGSSCSPCSAQFV-KNLN------------A----QEH-AEQY--P-EAADA I-VRK--HYVDDY-FDSAD-T---EEEAVRKASDVC-RV-HAKG-------GFEIR-NWV SNSE-EV-LRQL--GE------PKCAAKPLEV-----------------------D-KNC PT--E-----------------RV--LG-------------------------------- -----VLW---------------------------------------------------- ----------------------------------------------------------AK VDPFSYVGIDYFGPLD-------------------------------------------- ----------------------------VS--IG-R-----R-KE-----KR-WVA---L -FTCMT--VRAVHLEVAYSLTTESC-----KMAIRRF-VKRR-GSPTEIFSDNGTNFVGA NRDL-----------VRE-INA-G----------------------CA---DTFTSSKTR ----WTFNPPSAPHMGGAWERMVRSVKEALKA-FT--D---G-RKL----TDEIL----- --QTV-----LVEAEYLVNSRP--------LTY------------V----STNVK----- ------------------------------------------------------------ ----------- >1560/1-551 ---PTKRDIVAFNATTYDPSGLLSPILVLLKRFITI-MW-EKD----------I------ -DWDQ-R-IPQ--DMWPLWKTVAAQFTEKV-----YSMP--RQL---------------- ---V-TNYDYDSI-QLAV-FSDASKY-HYA-TTAYLR--FGF-KDE------RFES-K-- LIFA---------------------------KSRV-RPSSGGSE---------------- --------------------------------YSIPRMELVALE-IGV-NSAVNIAKE-- -L------H---IKI-KDI---NI---------FS------------------------- ------------------------------------EYYIPHRVV-------IKQ-ESLT TKL-RIVLDASSHMK-NQ---LSLNDCLYPGPSIL--QSILGILLRSR---LPKF--LMT ADIEKAFHAVMVQEK--FRDAMK-----F------IWLKN---P-EE----GFKESNI-A TYRFSRLPFGVTCSPFLLAVT-ILTY------------L-------DLDLD--D-FN-ER F-LEN--LYVDNV-MFTSN-S---EEDLMNCYTKSK-ST-CDKM-------HMNLR-EFM CNNG-VV-RAKIPEKDR--S---------------------------------------- AQTTG-----------------KL--LG-------------------------------- -----HQW---------------------------------------------------- ----------------------------------------------------------TM ESPFKHIGLDYIGPLP-------------------------------------------- ----------------------------FK-LGQ-RLG------------KV-WVL---L -LTCLV--TRAVHLEIVSDNTTVGF-----INGLKRF-IARR-GAPSSILSDNAPQFKLG YRMIN-K-------DLKT----------YINQ-----------DPSLT---TFLARHEIK ----IKLITPMSPWQGGIYERLVGIVKNILLKVLG--K-----GQH----TFLEL----- --ETL-----LIETEGIVNSRP--------ITS------------N-------------- ----------------------KK--------DIE--D-------SPAIR---------- ----------- >1563/1-550 ---PSKREVLSFVMSVFDPLGLISNVTIQGKILKQE-LHKE-T----------K------ -DWDT-P-ISE--RAQKIWNSWVEKVQTAS---N-IRIP--RWV--M------------- -KDV--G---THI-ELHT-FVDASDK-AFA-AIVYAR--SNTQ-QN-------PCV-R-- IMAA---------------------------KSRV-API--K-P---------------- --------------------------------LSIPRLELQAAL-LGV-RLADTVRQE-- -T------R-LKI---IGS---TF---------WT------------------------- -----------------------------------NLYYLPHFVV-------VNKN-KQP PKP-RLVFDAAAK-I-QG---QSFNSALLSGPDST--TSLFGILVRFR---EGRY--AVC GDIKEMFHQVKVRKE--DQDVQR-----F------IWRNC---E-Q----------RFPD IYVMQVMTFGSTCSPSCAQAA-KNHN------------A----ERL-KEKY--P-LALSP I-INQ--HYVDDY-DDSFN-S---LEEAKDTVTQII-KA-HDEG-------GFFIT-KFC SNDK-ML-LDTI--------PENRREMDTK-K-----------------------YLNDN EDEPE-----------------KI--LG-------------------------------- -----VYW---------------------------------------------------- ----------------------------------------------------------TY VYPFNHTGVDYFGPFE-------------------------------------------- ----------------------------VA--VN-R-----S-KE-----KR-WGA---I -FTCMT--TRAVHIELASKLDTDAF-----LLCFMNF-QNRR-GKVSHLYSDNGTNFIGA ERELR-S-------LVDQINSK-M----------------------EA---GQAIKLELE ----WHFNPPKAPHFGGAWERLISIVKNSLMETIT--SRKDH-SAP----NVETL----- --RGA-----LIQAEFYLNSRP--------LTH------------I-------------- ----------------------PL-------------EC--------------------- ----------- >1569/1-593 ---FTRRGILSTVNSLYDPLGFVCPITMQGRALVRE-LSTI-Q----------Q------ -DWDT-I-LPL--EKESSWKAWISSLAELD---Q-LQIP--QAY--V------------- -PTSVCR--APLC-ELCI-FSDASTL-AIA-AVAYLR--VIDS-NG------QPHV-G-- FVMG---------------------------RSKL-APF--P-A---------------- --------------------------------HTVPRLELCAAV-LAV-ELMEFIKGE-- -I------D-LEL---HDI---HF---------YT------------------------- -----------------------------------ECWYLPIFGV-------YHPH-K-P DKI-RVVFDSSAQ-F-RG---VSLNDVLLSGPDLN--NTLLGVLLRFR---REKI--AVM ADIEQMFYCFKVKEP--HRNYLR-----F------LWDKD---NCPE---------KEII DYRMTVHVFGNSPSPAVAIYA-LRQA------------A----EHG-KVEC--GTDAKNF V-LRN--FYVDDG-ITSVP-T---EREAIDLLKRTQ-TM-LSKS-------SLNLH-KVA SNSA-SV-MEAF-------PSSERAKDLKDLD-----------------------FSKDT -IPLQ-----------------HS--LG-------------------------------- -----ISWNLKTDCFMFKASQECKPFTRRGILSTVNSLYDPLGFVC-------------- ----------------------------------------------------------SV DPPFTYTGLDVFGPFT-------------------------------------------- ----------------------------VV--TR-KTRGHNI-EN-----KR-WAV---I -FSCLS--SRAVHLEVMESLSASSF-----ICALRRF-LAVR-GPVKHFRSDRGTNFVGA VKELQ-I-------D---SGDS-E----------------------LK---GFLQNQSCT ----WTFNAPHSSHMGGVWERMIGIARRILEALLI--KS--A-TRL----THEVL----- --TTL-----MAEVMAIMNSRP--------L--------------T-------------- ----------------------PI-------------ST--------------------- ----------- >157/1-551 ---PTKREVVKVVMSLFDPLGLISFFLVHGKVLIQD-IWAR-G----------T------ -DWDD-V-IPE--DLHDRWLQWTSLFPKLD---Q-LRIP--RCY--F------------- -RSAIPE-TPDCL-QIHV-FCDSSEA-AYS-SAAYLR--LEI--NG------VIEV-A-- LIGS---------------------------KTKV-APL--K-T---------------- --------------------------------ISIPRLELKAAV-LGS-RLLETLQSY-- -H------N-LQL---SRR---FL---------WS------------------------- -------------------------------------WYLPLGVV-------TSPK-K-P NKV-RLIWDAAAK-V-GE---TSFNSKLLKGPDLL--IPLPKVLCQFR---QFPI--AVS GDLMEMFHQIKIRFP--DCQSQR-----F------VFREK---P-TE---------Y-PQ VYVMDVATFGSTCSPATAQYV-KNLN------------A----QEF-SAEY--P-RAAEA I-VKR--HYVDDY-LDSFR-T---VDEAVETVNEVR-MV-HGKG-------GFTLR-QFL SNSR-EF-LNAI--GEI----AEEE-SKNLSL-----------------------E-RGE KL--E-----------------SV--LG-------------------------------- -----MKWLPRED----------------------------------------------- ----------------------------------------------------------PF VRTFTFVGLDYFGPVF-------------------------------------------- ----------------------------VR--IG-R-----S-LA-----KR-WVA---V -FTCLT--IRAVHLEVVHSLNTESC-----IMAVRRF-VARR-GPPREFYTDNGTCFQSA SRELK-E-E------IER-RNE-A----------------------LA---STFTSAETS ----WKFIPPAAPHMGGVWERLVRSVKVATSAVLD--A---A-RKP----DDETL----- --ETV-----LLEGEAMINCRP--------LTF------------I-------------- ----------------------PL-------------ES--------------------- ----------- >158/1-561 ----TKRVVLSDTARIFDPLGLISPVTVQAKIFLQQ-LWKQ-K----------S------ -DWDD-A-LPE--NFQAFWNEFRRNAGSLE---S-LSVP--RWT--G------------- --FRSS-LV--SV-ELHG-FCDASEA-AYG-ACLYLR--CESS-DG------SVTV-R-- LITS---------------------------KSRV-APL--E-DLSR------------- ---KKKK-------------------------QSIPRLELSSAL-LLS-HLYEKFRNS-- -V-H----L---S---ANA---YF---------WT------------------------- -------------------------------------YYLPHHAV-------LKPE-STT TKL-RVVFDASCRTS-SG---TSLNDGLMVGPVVQ--DDLLAIILRFR---CWEF--VLV ADIAKMYRMVKVAEA--DHPLQR-----I------LWRES---P-DQ---------PV-K TYELTTVTYGTASAPYLATKC-LQRL------------A----TEG-EVSH--P-TAAKV V-RKD--FYVDDL-LTGTD-S---LEDGKALATDLI-SL-TNSA-------GFILR-KWN SNSS-EL-LSTIPAELRDERT--T-L-ELD---------------------------S-- STSVV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TP GAVFLKVGIDLCGPFY-------------------------------------------- ----------------------------IRYP--GRKS---API------KA-FVC---I -FVCLA--TKAVHLEVVADLSTQAF-----LASFKRF-VAIR-GKPQLVMCDNATNFVGA NRELE-V-------LRRLLNDQ-QV------------------QHWIA---NAALEEGIE ----FKFIPPRTPNFGGLWEAAVKSFKGHFRKTIG--D-----RVL----TYDEL----- --HTV-----VSQIAAILNSRP--------LTP------------L-------------- ----------------------SN--------DPN--D-------F-------------- ----------- >1580/1-568 ---PTMREVLAFITSIYDPLGLISNITIQGKILYQE-LHVA-S----------L------ -KWDD-C-IPD--QLLVPWRDWMDLIKSVE---N-LSIP--RCI--T------------- -TEA--I---TEL-ELHV-FVDASED-AFA-ACIYSR--SKTH-YG-------FCI-R-- LLAA---------------------------KSRV-SPI--K-P---------------- --------------------------------ISIPRMELQGAL-LGT-RLMNQVKEK-- -L------R-VKI---TDI---TM---------WS------------------------- ---------------N---------------PGTDRVFYLPHFIV-------TNTN-KIP PKP-RLVFDAAAK-I-KG---VSFNSELLSGPDAT--SSLFGVLLRWR---EGMV--AVT GDIKEMFHQVKIRPE--DQQAQR-----L------LWRDC---D-PS---------KNPD TYVMQVMTFGSTCSPASAQAV-KNTN------------A----ELY-REIY--P-DAVDS I-IDG--HYVDDL-LDSFN-N---AVTGIKVVRQIT-EI-HDHA-------GFHIR-NFA SNSP-EL-MDLI--------PENRRMVANV-K-----------------------SLDEK ESNVE-----------------KV--LG-------------------------------- -----IYWNTLQDSIGYKL----------------------------------------- ----------------------------------------------------------GY VRPFTNCGVDYFGPYK-------------------------------------------- ----------------------------VN--IT-R-----NITD-----KR-WGV---L -FTCMA--SRAVHIEMAPKLDTDSF-----LLCLRNL-QNRR-GKVAKLYSDNGTNFVGA DAVLK-S-------LVKEINAK-M----------------------ES---GTAAEMEIS ----WHFNPPGAPHFGGAWESLVKLAKQAIREMMD--KWKEN-VLP----KPESL----- --QAA-----FIQAEFILNSRP--------LTD------------V-------------- ----------------------PI-------------NC--------------------- ----------- >1584/1-568 ----TKRSVLSKIARLFDPIGLVGPVVTSAKLFMQE-LWLL-K----------H-ENGES WGWDE-E-LPG--TVKERWLVYCEQLPRLN---E-LRIE--RWV--L------------- --CP-T-PS--SI-QLHF-FSDASKL-AYG-ACCYIR--SANS-TA------TVKV-A-- LLTA---------------------------RSRV-API-------K------------- ---X----------------------------QSIPRLELCGAL-LAT-ELFQKVSTS-- -L-K----R-F-----DEV---YF---------WV------------------------- -----------------------------------PCYHLPHHAV-------LREE-STT TKV-RVVFDASCKTS-RG---PSLNDALMVGPIVQ--EELRSIIMRAR---THPI--MLI ADIKQMFRQILVDEK--DTPLQR-----I------VWRTT---P-DL---------PL-D TYELKTVTYGTACAPFLATRV-LHKL------------A----DDE-HENF--P-MATEV L-RKD--FYVDDL-FSGAD-S---VEEAIELREQLD-TL-LSKG-------GFVLR-KWA SNIP-AV-LHGVSPDNRALQS--S-V-DFD---------------------------P-- -DQCI-----------------KT--LG-------------------------------- -----LYWEPSTDYLRYRI----------------------------------------- ----------------------------------------------------------TA SRPFSKTGIDYWGPIS-------------------------------------------- ----------------------------LQPP--HRRA---GPR------KA-FVA---V -FVCFS--TRAVHLELVVDLTTAKF-----LQALRRF-VSRR-GLCNEIYSDNGRNFLGA ANELR-K-------L---IQSK-EH------------------HNAIA---NECASNNIR ----WQFNPPKASNFGGLWEAAIYSAQKHFVRVLG--T-----STL----AHDDM----- --ETL-----LSQIECCLNSRP--------ITP------------L-------------- ----------------------TD--------DPT--D-------Y-------------- ----------- >159/1-560 ---WTKRRVFSAIAQLYDPLGLVSPVVAWAKIQMQH-LWLL-S----------L------ -DWDD-L-VPD--EISDKWLEFYRQLPLLQ---D-FKVP--RCI--F------------- --SK-N-CT--IM-QFHT-FSDASEV-GYG-ACIYAR--SISE-GG-------INV-Q-- LIAS---------------------------KSRV-API-------K------------- ---R----------------------------LSLPRLELCAAL-LGA-KLYAKVTGA-- -L-K----M-E-G---TPC---WF---------WS------------------------- ------------------------------QNEQRTVCYLPHHPV-------FKES-SST TKV-RVVFDGSAKTT-TG---CSLNDALLTGPVIQ--DDLIDLMIRFR---KHNI--ALV ADVAKMYRQVRIHSD--DTPLQR-----I------LWRFN---Q-DE---------PV-Q IFELQTVTYGLSPSSFVATRV-LKQL------------A----FDG-GSKY--E-HAAAA V-TDD--FYMDDF-LSGAE-S---VEKAKSLRTDVQ-SL-MAEG-------GFELR-KWS SNSP-EA-LHDLPPDSLEGQT--T-V-HFD---------------------------A-- -EQKV-----------------KT--LG-------------------------------- -----VAW---------------------------------------------------- ----------------------------------------------------------VP SRPFSTTGVDFCGPLY-------------------------------------------- ----------------------------LKPV--HRRA---APQ------KV-FIS---V -FVCFA--TKAVHLELVCDLSTDAF-----IAALRRF-IARR-GIPAEIQSDNGTNFQGA KKKLT-E-------LHHIFNTK-PN------------------QRAII---NECSSKGIS ----WRFIPPRAPNFGGLWEAAVKTAKSSLAKTIG--C-----HQL----SYEDM----- --VTV-----LYQIEANMNSRP--------LTP------------L-------------- ----------------------SD--------DPS--E-------L-------------- ----------- >160/1-523 ---PTKRQVLRCFMSFFDPLGLLGFLLVHGKILLQD-IWRA-G----------T------ -QWDE-E-VEE--EHWNRWRDWTSLLRQVS---D-IRIP--RCY--F------------- -PEATEL-HYQQL-QLHV-FVDASEA-AYA-AVAYFR--IADP-NG------IVRC-V-- LVST---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-LGT-RLMRFVQES-- -H------S-LII---KER---YL---------WS------------------------- -------------------------------------WYLPLGAV-------VNPK-K-P EKV-RLIWDAAAM-V-DG---ISLNSMLLKGPDQL--VSLPGVLFRFR---QYNV--AVS ADIKEMFHQIRIREE--DRHSQR-----F------LWRDD---P-SK---------P-AE TFVMDVATFGSTCSPASAQYV-KNLN------------A----TKF-AKKY--P-KAAKD I-IEN--TYVDDY-LASFQ-T---ENEAAETSAQVR-TI-QQAG-------GFSLR-NWQ SNSA-SV-IQGL--GEP----VHL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SF TRPFTYVGLDYFGPFV-------------------------------------------- ----------------------------VK--VG-R-----G-NA-----KR-WIA---L -FTCLT--IRAVHCEIVCSLSTDAC-----LKAIRRF-VCRR-GAPAEIYSDNGTNFQGA ERILM-K-E----------IQQ-G----------------------MA---ETLTSTTTN ----WLFIPPASPHMGGAWERMVRSIKQAMMSAYR--C---D-RKL----DDESL----- --HTF-----VIEAESMVNNRP--------LTY------------L-------------- ----------------------PL-------------DA--------------------- ----------- >1600/1-550 ---PTKRDVASKLAETFDPLGLVSPIMVPFKRLMQR-IWENGK----------S------ VNWKD-R-IPK--ELLPDWRALRNTFIDRE-----LTVP--RQL---------------- ---T-SNYDYSEV-HLLM-FSDASQD-MYA-ACCYAC--YIV-KGE------TPVV-T-- LLTS---------------------------KNKI-RPSKHE-S---------------- --------------------------------WTIPKLELLAIQ-LAS-NLACAIVAE-- -L------R---ITI-NSI---KL---------FT------------------------- -----------------------------------PKYTIPHRGV-------VKE-DSLT TKL-RIVLDASSHAR-GE---LSLNDCLHAGTNMI--TPIFGILIRMR---CPRF--IIV ADIEKAFHQVRLQPE--FRNVTM-----F------LWLKD---I-TA----PVSAENI-E VYRFRRIPFGMSSSPFLLAAY-ITYN------------L-------DINPH--E-LN-EE I-KDN--LYVDNA-LFCTN-D---RSEIATKIKGTK-FI-FKRM-------DMNLR-EYI VNDP-DT-MESLPESEK--A---------------------------------------- QATTI-----------------KL--LG-------------------------------- -----YKW---------------------------------------------------- ----------------------------------------------------------TP SKPFSKVGLDYLGPIM-------------------------------------------- ----------------------------YRGDDGQTNK------------KA-YVL---V -YTCLI--TRGAVLRVVPDGTSQRY-----ILTLKMI-FREV-GVPNVIFSDNASTFKLG GSMIN-K-------DIED----------SV-Y-----------SHSLV---SFLASEVID ----FKYITPLAPWQGGIYERIVKLVKHQLIKECG--I-----RTY----DFYDL----- --QYI-----VSGAQAMVNNRP--------LIP------------H-------------- ----------------------SR--------SPR--D-------M-------------- ----------- >1602/1-536 ----TKRLILSRIASVYDPLGVLSPVILRGKLFFQT-LWN-RP----------H------ -GWDSNS-LSP--DELQQWKDIEASWTG-D---V-IERP--RLL--F------------- ---QTPNSDSDHF-ELHV-FSDACES-AYG-AVAYLR--RI-SKSG-------IDT-A-- FLMA---------------------------KVKI-APH--K------KS---------- --------------------------------LTIPQLELLGVE-KAA-ALAVFLKTE-- -L------D-MDVD---KT---FI---------WS------------------------- --------------------------------------------------------TSKT TKV-RIVFDASARSR-KD--APSLNDVLHTGESLL--PKIPGILLRCR---KPPI--LIS GDIEKAFLMLSLAQA--DRDACR-----F------LWT-------------SPGDSKP-T CYRFQRVPFGVKTSPYLLNAV-LKKH------------L-------LACDS--P-MA-HS I-LRN--IYVDNV-FYGVD-S---IESGVDLFRKSK-EL-FASA-------QMNLT-QFF SNCD-KL-NKTLTDMDHSDSP--------------------------------------- ITADQ-----------------KI--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------EF APPFTTIGLDYAGPIQ-------------------------------------------- ----------------------------AQSR-GQS--------------QPYWFI---V -MTCLT--TRYTYIDLVDSLSASSL-----LNALRRF-SALY-GTPATIITDNARQMHMM DDCLK---------ELK--EQSKK---------------------------PYFNSYDWP ---TFKFIPALSPWQGGVYERIVGIIKRCLARAGT------HKSLF----QLDDL----- --ITL-----LKETEAIINDRP--------LTT------------V-------------- ----------------------DT-------------DTNLLPLRPCDF----------- ----------- >1603/1-545 ---ATRRGILSVVSSFYDPLGMVAPALLPPKMILQD-LCKE-S----------L------ -GWDD-E-IPE--KHFNAWQEWESDLQLLS---SKFEVD--RCL--K------------- -PRGFGT--PTSV-QLHH-FADACEV-GYG-TASYVR--MENQ-EG------KVHC-T-- LLVG---------------------------KSRV-TPL--K-K---------------- --------------------------------ITIPRLELNAAV-VAV-RVDSMLKRE-- -L------D-LKV---DRT---HF---------WT------------------------- ---------------K---------------TESGRVWYVPHHGV-------YHPQ-K-- GKM-RVVFDCAAS-Y-AG---TSLNKELLQGPDLT--STLFGVLTRFR---QEPV--ALM ADIEAMFSQVKVPSE--DRDYQR-----F------MWWPE---GQIN---------KPLE EYRMTVHVFGATSSPSCANYA-LKRL------------A----DDC-KDQY--DEEVLKA I-KGD--FYVDDL-LKSTE-T---VEKGQCLAEDIR-SV-CGTG-------GFRLT-KWI SNYQ-QV-IKAV-------PVTERAEEVKNLD-----------------------LK--- ------------------------------------------------------------ ------------------------------------------------Y----------- ----------------------------------------------------------PD EPPFTRVGVDYFGPIE-------------------------------------------- ----------------------------VK--RG-R-----S-TV-----KR-YGV---I -FTCMA--TRAVHIEKADSLDTDSC-----ISALRRF-VARR-GQVKQIWSDNGTNLVGA KAEME-K-------EIKKWNER-Q----------------------IS---ETMLKKNVD ----WRFNPPTGSHFGGVWERQIRSIRQVLNAISK--Q---K--LQ----DDEGL----- --RTL-----FCEVEYIINGRP--------ITA------------V-------------- ----------------------S------------------------MDI---------- ----------- >1608/1-569 ---PTKRVLLKIIMSIFDPLGFLTPFTIEAKLILQG-VWNS-K----------I------ -GWDE-C-IQD--TEFDQWKRWLQKLDXIK---L-LHIP--RSY---------------- ---RSKNCQVKSA-ELHI-FCDASSK-AYA-AVAYWRICLKDD---------SYHV-S-- LIMA---------------------------KSRV-APMKET-T---------------- --------------------------------VTIPRLELQAAV-LAI-RVANIIAKE-- -H------D-FQI---SRR---VF---------WS------------------------- ---------------K---------------PSGSRIWYLPHFGV-------SNIN-K-P GKV-RLVFDAAVA-T-SS---VSFNKLLLSGPDLL--KSLLGVLMRFR---XFHY--AIK DDLRDMFLKINIQEA--DRDAQR-----F------LWRGC---D-RT---------IEPD KYVMSSVLFGAKSSPFTALFI-KNKN------------A----SLC-SSTY--P-AAAKS I-IEN--SYIDDF-LESCE-T---REEASSRVQQVV-EI-NKHA-------NWEMH-GWA SNDA-SV-LSNS--------NINSNDKQPINF-----------------------ETKDN I---E-----------------EI--LG-------------------------------- -----LRWVNSTDELIFKI----------------------------------------- ----------------------------------------------------------YR LRPFSHCGIHYFGPLN-------------------------------------------- ----------------------------VK--VGYR-----R-RE-----KR-WGV---L -FTCMS--TRAVHIELAQTLSTSSA-----ILALKLF-TGRR-GTPFVIYSDNGTNFIGT NNEIX-K-------ALKDLDRK-K----------------------LN---EFAAKKQIV ----WKFNPPTASHMGGAWERLIRSVKNALNVVFK--D-----QAY----CEELL----- --QTI-----LIEIEHCINSRP--------LTH------------V-------------- ----------------------SI-------------DPRDK------------------ ----------- >161/1-542 ---PTKRIALRCVMSMFDPKQFLAPLLIHGRILMQN-LWRS-G----------I------ -GWDE-K-LGE--EHYDQWLRWTRLLPLID---D-IQIP--RCY--L------------- -GEMSST-VYDTV-QLHV-FADAGED-AYG-CVAYFR--FTDG-KN-------VHC-A-- FVEA---------------------------KAKV-APL--Q-Y---------------- --------------------------------LSIPRKELEAAV-LGA-RVMKAICES-- -H------S-VKI---KKY---FL---------WT------------------------- ------------------------------------CWYLPLNYV-------VNSK-K-P GKV-RMIWDAAAR-T-NG---VSFNDXLLKGPDLV--APLSGVINGFR---ERQV--AFG GDIREMFHQILVRKE--DRQSQR-----F------LFRFD---M-NF---------E-PE IFVMDVVIFGASCSPCLAQYV-KNMN------------A----REH-VQEY--P-EAADA I-IRK--HYVDDY-FDSVD-T---ENEAIVRAKAVR-KV-HANA-------GFEIR-NWV SNSS-KV-LKEL--GE------V-EPQEVKLL-----------------------DMSAS DT--E-----------------RV--LG-------------------------------- -----IMW---------------------------------------------------- ----------------------------------------------------------VS EHPFSYVGVDYFGPIE-------------------------------------------- ----------------------------VV--VG-R-----R-RE-----KR-WVA---L -FTCMT--VRAIHLEEVYSLTTQSC-----EMAIRRF-VKRR-GSPIEIFSDNGTNFVGA SKDLE-A-Q------IRT-INV-E----------------------CA---DTFTGAKTK ----WTFNPPSAPHMGGVWERMVRSVKAAMSV-FA--N---G-ERL----TDEIL----- --QTT-----LAEVEHLINSRP--------LTY------------V----S--------- ------------------------------------------------------------ ----------- >1610/1-533 ---PTKREVVAFLAMNYDPTGLISPIVVPVKKFITL-LW-NPD----------L------ -KWGD-R-IPD--ILMPMWTAITKVFTVNT-----YTIP--RQL---------------- ---V-TTYDYTHV-DLVV-FSDASQD-HYA-AAAYLR--YDY-QGK------HYQS-Q-- LIFS---------------------------KSRI-KPGRNG------------------ --------------------------------ITIPQLELLALQ-TGT-NVALNLIEE-- -L------H---IPI-RKV---TF---------FS------------------------- -------------------------------------YYFPHRDV-------IKE-DSNN TKT-RIVLDASSHEK-GK---LSLNDCLHPGPSIL--QKIMGILIRSR---LSKY--LMI SDIEKAFHQVRLQKQ--CRDVTR-----F------LWLED---P-EL----DATPDNI-V TYRFTRLPFGVTSSPFLLAMT-ILQY------------L-------EFDPD--P-IN-AR I-IEN--LYVDNV-LLTTN-D---PVELASLYTKLK-EV-FQKM-------HMNLR-EFL CNNS-EV-M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------KL----------QL VAPFAFVGLDYFGPLR-------------------------------------------- ----------------------------YK-TKE-DNG------------KI-WVL---L -VTCLV--TRAVHLEIVQDNTTHSF-----ILALKRY-FGRR-GVPQSILSDNAPAFKLG YNIMN-K-------DIKS----------LINT-----------SLTLT---SFLADKEID ----IRLITPFSPWKGGIYERLVALVKNMLHKVLG--K-----ITI----PFLEL----- --ESL-----IIESEGILNSRP--------ITA------------N-------------- ----------------------KI--------HVA--D-------AKPIRPVDY------ ----------- >1612/1-553 ----TRRKVLSQIAKTFDPCGMTSPIILAAKLFRQE-IENGKN----------L------ -KWDS-K-LSD--SEEQKWKELMLTWEN-K---E-IKYP--RKL--F------------- ---QNNLSEHTKF-QLHA-FTDACSK-AFG-AAIYLR--IENDQQ--------IYC-N-- LVFA---------------------------KSLV-VPA--N---MPKGK---------- --------------------------------RTIPNLELHATM-LCG-KYLNFVKIE-- -F------E-KEIKI-QNC---TI---------WS------------------------- ---------------------------------------LPHHGV-------VKE-TSEH TKL-RIVYNASAKSG-KN---PALNECIEKGTNEY--NDLTGIQLRTR---LKNI--LIG SDIAKAFHQIELAPE--DRNCVR-----F------LWVED---P-FD----PNSP--L-I HYRFKRVTFGVICSPAQLALT-IKLH------------L-------EKYNH--P-II-KQ L-AQN--IYVDNL-LVGIN-H---KKDFQMVYELIK-KV-FAKA-------GMNVR-EFV SNEL-SE-LQKLPKEDR--I---------------------------------------- EKETV-----------------KL--LG-------------------------------- -----IWW---------------------------------------------------- ----------------------------------------------------------KG KSAFEHVGIDYFGPLS-------------------------------------------- ----------------------------VKT--LDGNK------------KC-WGA---I -FTCLI--VRAIHLELVSDVSAEKF-----LLAFRRF-IKRR-RVPKLIISDNGTNFVLA SKALK-Q-------IALEENKQ-NRIWSEIYR-----------DPMIQ---NFSSNLGID ----WQFNSPYASWRGGAYERMIGLVKTHLIRSLG--K-----RLL----SFEEL----- --MTY-----LIEVERIVNERP--------LSY------------I-------------- ----------------------TQ--------D-E--V---------------------- ----------- >1616/1-518 ----TMRTIYKILASQYDPLGFLTPYLTRAKVLVQQ-LWAK-R----------R------ -DWDD-PDLPL--DLCESWKQWESELPNIS---A-ISIP--RSY--L------------- -PDGMDQ-PNTEH-HLHV-FCDASEK-AYG-AVAYL---SSTQ-GG------ATNV-A-- FVMA---------------------------RSKV-APK--R-Q---------------- --------------------------------QTMPRLELCAAL-AGA-QLANLIQTE-- -L------S-VTL---QRT---TL---------WT------------------------- -----------------------------------ESWYLPHHLV-------YHN----- DKA-RLVFNCSHV-Y-KG---TSLNDQLLPGPNLG--PSLIGVLLRFR---QHQV--AIS GDIRGMFHQVHLLPE--DTPLLR-----F------LW-RD---LQQE---------ASPE IYEWQVLPFGTTSSPCCAIYA-LQRH------------V----REH-PRS---TPGLIES V-ERS--FYVDNC-LESHP-N---GAAAQARVDDLR-SL-LADG-------GFDIR-QWA SNRS-SV-VAHL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------IF SPPFHSTGIDCYGPFI-------------------------------------------- ----------------------------AK--IG-R-----R-HE-----KK-WGV---I -FKCLT--TRAVHLDLLNSMDTDAF-----LLALRRF-IARR-GRPVEILSDRGTNFRGA DAELR-A-------AFEEMETQ------------------------LQ---QQLASYQIE ----FKFNPPNAPHFGGVWEREIRSIKNALQVAVG--T---Q--PL----PEDVL----- --HTI-----LVEVEGIIDSKP--------LGY------------V-------------- ----------------------SA-------------DI--------------------- ----------- >1617/1-547 ---PTKRQVASKMAETFDPLGLITPLIVSFKRLMQN-LW-RNP----------M------ -KWND-P-IPK--ELLADWKAIQAAFMDTK-----ITVP--RRI---------------- ---SISDDPPEEI-QLIM-FSDASTD-IYA-TAVYVQ--YSY-KSR------KPVT-R-- LLTS---------------------------KSKI-RSAKNE-M---------------- --------------------------------WTIPKLELLGIE-CSS-NLARTIIAELG TL------A---TKI-KKV---RL---------FT------------------------- ------------------------------------KYYTPHRAV-------IKE-TSNT TKL-RIVLDASSPPG-PE---PSLNDCLYAGDNLV--TPLYGILLRGR---IYPY--VVV ADIEKAFHQVRLPTE--FRNASL-----F------LWLKD---I-TK----PPTPDNI-C TYRFTRIPFGVASSPWLLAAS-ILHF------------L-------DRNPN--P-LN-QR V-REN--LYVDNC-LIGTF-D---KSEITEIIKNSK-DI-FMKM-------KMNLR-EYV TNSE-EH-MVAIEVEDQ--A---------------------------------------- KHRVI-----------------KL------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SKPFAKVGLDYLGPVE-------------------------------------------- ----------------------------YLRDDQESIG------------KA-YVL---L -YTCLV--TRAAVLRVVPDATTESY-----LMALRTI-FHQV-GVPSEVHSDNAAIFKLG AKMTN-D-------DIRE----------GSEI-----------DEIFT---CFLASQEIK ----FIYITPWSPWQGGVYERIIGLLKHQIHKICG--D-----QKL----DFFSL----- --QYV-----VSSAQAMINNRP--------LVA------------H-------------- ----------------------AR--------SPN--D-------M-------------- ----------- >1618/1-574 ---TTKRIVVSEMAQLFDPAGWMGPVLMSVKIFVQH-LWAT-N----------K------ -GWDD-P-LSP--EDDRWWKDFRREIPMLQ---Q-VEVP--RRV--I------------- --GN----TTRNY-KLHC-VCDASTK-GYG-CSVYVV--GPDE-KG------KMQS-R-- LLIS---------------------------KSRV-APV-------C------------- ---G----------------------------QTVPRLELCAAL-LGA-ELVNLLLET-- -T-D----F-V-----GPV---TF---------WS------------------------- ------------------------------SRVAGPQFFLPHHAI-------QRPG-SST TKT-RVVFDGSAKGS-GR---FSLNSILHTGPTVQ--PPLLSTILNFR---LPKF--AFT ADAEKMFRQVWVHPE--DRKWQQ-----I------IWRKN---P-TE---------TL-Q IYQLKTVTYGLASSPFHAARV-LNQL------------A----EDE-GHRY--P-IGAQI V-GKR--FYVDDV-LAGAD-T---LEDADEACHQVR-EL-FQLA-------GFSLR-KWS ASHP-DI-LQRIPQDLWESSP------TKE----------------------------IG EPDFA-----------------KA--LG-------------------------------- -----LLWDPRADCFRFKIPTF-------------------------------------- ----------------------------------------------------------TP TRVFANSGLDYCGPFL-------------------------------------------- ----------------------------VRPL--YGRG---ANV------KM-YVA---V -FVCLS--VKAVHLEVVPDLTTTAC-----INGIKRF-VGRR-GRLIELRCDNATAFVGA DRELK-E-------LRKRYLEQ-FR------------------TAEWE---NYCLDSGIT ----FRFIPPRSPHFGGLWEAGVKSFKHHFRRIFG--G-----RSC----TVDEL----- --TTA-----VVHIESILNSRP--------LTP------------L-------------- ----------------------TD--------HPD--D-------L-------------- ----------- >162/1-554 ---PTKRQMLKCLMGIFDPLGLLCAFLVHGKILLQD-VWRA-N----------V------ -QWDE-T-VTG--KIFDRWVKWTGLFSRVG---D-LRIP--RCY--F------------- -RGATAQ-MYEHL-QLHV-FVDASEA-AFA-AVAYFR--VVNA-EG------EAEC-S-- IVAA---------------------------KSKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-LGS-RLMSFVQEN-- -H------S-VKV---KQR---FI---------WS------------------------- ---------------R---------------ADPKRVWYLPLGVV-------TNPR-K-P GKV-RLIWDAAAK-V-DG---ISLNSMLLKGPDQL--TSLPAVLTRFR---QYKV--GVS ADIQEMFHQLLIREA--DRHSQR-----F------LFRSD---P-LK---------P-LE IYLMDVATFGSTCSPASAQYV-KNKN------------A----EEF-AVLY--P-RAAEE I-LEN--HYVDDY-LSSYE-S---AEEAERVSREVR-SI-HQEG-------GFKLR-NWL SNSS-AV-LHGL--SEE----DPKA-IKSLCL-----------------------S-AAE SS--D-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------SF SRPFTYTGVDFFGPFL-------------------------------------------- ----------------------------VK--VG-R-----S-AA-----KR-WIC---L -FTCLT--IRAVHVEVAHSLSTPSC-----IKAIRRF-VDRR-GAPAEIYSDNGTNFQGA EHLLR-E-Q------LKE-IHG-N----------------------LA---ATFTNTDTK ----WIFNPPAAPHMGGAWEKMVRSVKSAMQASYN--S---D-RKL----DDEGL----- --ETL-----AVEAEGIVNSRP--------LTY------------L-------------- ----------------------PL-------------DA--------------------- ----------- >1624/1-540 ---ATKREILRTQMSLYDPMGLVGHFIMYLKVLLQE-IWRG-G----------F------ -SWDE-E-LDG--GIADKWTTWLRVLPAVQ---N-VTVP--RCY--R------------- -HVCST---NAKR-ELHV-FCDASEN-GMA-AVAYLR--FEE--GD------HIEC-A-- LVGS---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRLELQAAV-IGA-RLADTIRRS-- -H------R-LEV---SRT---IF---------WT------------------------- -----------------------------------NDWYLPIFPV-------TNPN-K-P GKI-RMVFDAAAK-V-NG---VSLNSLLLAGPDLL--AGLLAVLLKFR---EFRV--GVV GDIREMFHRVGIKKE--DQRSQM-----I------FW-GE---S-NR---------GDPD VYVVTVMTFGAACSPTSAQFV-KNRN------------A----ERY-RKDF--P-RAVDC I-KEE--HYVDDM-LASVE-T---EEEAFELADTVR-YI-HAKG-------GFEIR-NWA SNSR-EV-ITML--QA---APAD---GKDI------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------IA QRAFSFTGIDYFGPFL-------------------------------------------- ----------------------------VV--VG-R-----R-EE-----KR-WGV---L -ATCLT--SRAVHLEVAASLTTASC-----ILAIRRF-IARR-GMPLEMISDRGTNFVGA SRELR-E-------ALEEVDHD-A----------------------LM---TEFCGPKMK ----WTFNPPGAPHFGGCWERLVRSVKKVLNQCIF------P-RRP----TDEIL----- --LST-----FTEIELIINSRP--------LTY------------V-------------- ----------------------PL-------------DDEMAQPLTPNHL---------- ----------- >1629/1-543 ---CTRRGVLSEVSSVYDPYGFASPYVLNAKIILQE-LTAM-K----------L------ -DWDE-P-LPE--KQRESWLNWKRDLLLME---D-FNIS--RCL--K------------- -PHDFGD--VTEY-QLHH-FSDASER-AYG-VASYLR--VTNQ-EG------KVYC-S-- LVMA---------------------------RTRL-TPL--K-R---------------- --------------------------------VMIPRLELMAAT-LAV-RLDGMLRRE-- -L------D-FTL---SDS---VF---------WS------------------------- ---------------A---------------GSGKPVWYLPHHPV-------ENPN-K-P GKT-RIVFDCAST-Y-QE---RSLNDAVLQGPDLT--NTLLGVLLRFR---QEPI--AIM GDIQAMFHQVQVPPD--ERDMLR-----F------LWWPE---GDIE---------RQPM VYRMCVHLFGGTWCPSVCSFV-LRHT------------A----EDQ-AEEF--SPDAVNV V-KRN--FYVDDC-LVSVK-E---EDKAVQLVDELK-RM-LKGG-------GFNLT-KWL SNSP-KV-MESV-------PAHDRAKEVEGLD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SD EPPFSRVGIDYFGPLE-------------------------------------------- ----------------------------VK--RG-R-----S-VV-----KR-YGV---L -FTCLT--VRAVHLEMADSLDTSSC-----INAIRRF-IARR-GNVREIRSDNGTNLVGA ERELR-T-------EIQSWNQA-Q----------------------IH---DTLLQKNIK ----WTFNPPAASHHGGVWERQIRTVRKLLCSLVK--Q---Q--TL----NDDSL----- --HTL-----FCEIESIMNSRP--------ITE------------V-------------- ----------------------S------------------------SDV---------- ----------- >163/1-558 ----IKRVVCSELAKIFDPLGIFAPVVVRAKIFMQQ-LWES-K----------I------ -GWDE-E-LSP--SLQQDWKIYRDDLQSLN---K-LKIP--RHM--F------------- --DGKI-PV--AR-EIHT-FVDASEK-AYG-AATYIR--ATYK-DN------GITV-R-- LLCA---------------------------KSKV-APL--S-R---------------- --------------------------------QSLPRLELCAAL-LGA-ELTARVRKD-- -L-N----M---K---SSCNPAYL---------WT------------------------- -----------------------------------SHYFIPXHCV-------LKPD-SST TKL-RVVFDASAKSS-SG---KALNXILYAXPTVQ--SELFSILXRFR---THKX--XFT ADIEKMYRQXWMNPA--DQFHXM-----I------VWRNS---P-QE---------QL-K YYRLKTVTYGTTSAPFLATKC-LQHL------------A----NSS-KDQY--P-VGAKA V-EYD--FYVXDC-LTGAD-S---ITEAIRLRDEXN-KI-LLPA-------GLRLR-KWC ANHD-QI-LXGISKEDTTQMVKLD-NT--E------------------------------ -DNSI-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------SP ARPFKNAGVDYCGPFW-------------------------------------------- ----------------------------IHHK--VRGK---RPD------KA-YIA---I -FCCFA--TKAIHMETVSDLTTDKF-----IAALKRF-MGRR-GNCQTLHCDNATNFVGA NNKLK-E-------LEDAIYSD-KA------------------KDRIL---AECHKTNVK ----FHFIPPRAPHFGGLWEAAVKSAKHLLLKNVS--T-----ASL----TYDEL----- --ETV-----VIEIEAILNSRP--------ITP------------M-------------- ----------------------ST--------DPN--D-------L-------------- ----------- >1630/1-540 ---PTKREVLRTLMATFDPLGLISNILIYLKILFQE-ICRT-G----------I------ -EWDE-I-IPD--NLHEKWERWLEILPKVQ---E-VRIP--RCY--R------------- -VNTELG-PRTNV-QLHT-FVDVSMS-GYS-AVVYLR--FEQ--GS------RVEC-A-- IVGA---------------------------KTRV-SPL--K-L---------------- --------------------------------VSIPRLELQAAV-IGV-RLADTVMKT-- -L------S-FPI---NQR---FF---------WS------------------------- -----------------------------------RVWYLPLFPV-------FNPN-K-P GKV-RIVWDAAAK-T-NG---ISLNSLLLKGPDFL--TPLDYVLYRFR---EFRV--GLS GDVREMYLQLLMSKE--DQQCLR-----V------LWRDE---P-SK---------E-PS IYVTQVMPFGTCCSPSCAQYV-KNLN------------A----SKF-EGQF--P-AAAQA I-TKQ--HYVDDM-LVSVE-T---EQEAIKLAKDVK-YV-HAQA-------GFDMR-NWI SNST-AV-VEAM--DE---KTKQ---EKSMNI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF ARPFSYVGIDYFGPMS-------------------------------------------- ----------------------------VV--VG-R-----R-IE-----KR-WGV---L -LTCLT--MRAVHIEIAYSLNADSC-----VMAIRNF-MARR-GVPIQIYSDRGTNFTAA KKELA-AANEELIVALKELNQD-K----------------------VV---AEIVSTDTD ----WTFLPPASPHMGGAWERLIQTVKRNLQAMKP------G-RNP----SDEVL----- --RNT-----LMEIENIVNSHP--------LTY------------V-------------- ----------------------PI-------------ED--------------------- ----------- >1635/1-571 ---PTRRGILSMVNSVYDPLGFLAPFTLKAKLILQE-LCKT-G----------C------ -GWDE-K-IPD--NLQGPWEKWFKDWDWLS---N-FQIP--RCI--K------------- -SSDFGE--FKTV-QLHH-FCDASEC-GYG-TVSYLR--YSNN-KN------ETET-A-- FVLA---------------------------KARV-APL--K-Q---------------- --------------------------------ITIPKLELTAAT-LAS-RIDRMLKRE-- -L------C-LPL---EKS---VF---------WT------------------------- ---------------D---------------KPDGKVWYIPYHGV-------YHKR-K-- KTI-RVVFDCTSS-F-RD---VSLNKALLQGPDLA--NNLIGVLLRFR---LEPI--AFM ADIQNMFHQVRVLPD--HTDFLR-----F------LWWPN---GNFE---------TNLE EYRMKVHLFCAISSPSCANFA-LQRT------------A----DDN-ENVY--GKEVADT I-RYN--FYVDDC-LKSIA-T---EKQACELAKNLK-EM-CAKG-------GFKLT-KWV SNSK-VV-VSSL-------SETEKGNPIQDLN-----------------------LDRKR -LSVE-----------------HA--LG-------------------------------- -----VEWDTNEDVFTFNI----------------------------------------- ----------------------------------------------------------PD LPPFTNTGIDYFGPME-------------------------------------------- ----------------------------IK--RG-R-----T-HV-----KR-YGV---I -FTCLV--SRAVHLEVANSLDTDSC-----INAIRRF-IARR-GPVATIRTDQGTNFIGA QKELQ-E-------TLKTLKHE-K----------------------IT---RILTDIGVN ----WMFNPPSAAHFGGVWERLIKSVKKVLYSVTK--E---Q--IL----DDEGL----- --HTA-----MCEVEMTLNDRP--------ITS------------I-------------- ----------------------SN-------------D--------PNDL---------- ----------- >1636/1-586 ---PTKRQIVAFLAKIYDPTGIVTPIGIQTKQLVSC-LW-EHK----------L------ -KWSD-P-IPE--SLLTLWSSIANQFTSTS-----YTVP--RQL---------------- ---V-TSYDYINI-QLIM-FSDASKF-HYA-TTAYLR--FEY-PNH------SFQS-R-- LLFC---------------------------KSRV-KPRKVG------------------ --------------------------------ITIPQMELMALE-TAT-NAAINLQKE-- -L------H---IKI-SKV---FF---------FS------------------------- -----------------------------------PSYFIPHHCI-------VKE-DSIH TKL-RIVLDASSHGK-GK---VSLNDCIHAGPAIL--QRIMHILLRCR---LTQF--LLI SDVEKAFHQVRLQEQ--CRNVTK-----F------LWLKD---P-LK----GATPDNI-V MYRFTRLPFGVNCSPFLLAIT-ILQY------------L-------EIDPN--P-IN-QK I-VEN--LYVDNV-IMTSN-D---QEEILSYYNQLK-LS-FGKM-------HMNIR-DFQ VNSS-EV-MDHIPPQDR--S---------------------------------------- PNNVN-----------------KV--LG-------------------------------- -----HLWNGADDTLTIKLPSPPPGVPTKRQIVAFLAKIY-------------------- ----------------------------------------------------------DI VHPFAYVGLDYFGPIR-------------------------------------------- ----------------------------YQ-SRD-DNN------------KV-WVL---L -VTCLV--TRSIHLEVVPDNTTHSF-----ILALKRY-FGRR-GVPKSILSDNAPTFKLG YSIMN-T-------DLKT----------LINN-----------SLTLT---SFLEGRQIK ----IRFITPYSPWKGGIYERLVAIVKNMVFKVLR--K-----ITL----PFLEL----- --ESL-----LIETEGIINSRP--------ITS------------N-------------- ----------------------KI--------HLT--D-------AEPIRPVDF------ ----------- >164/1-554 ---PSKREMLKITMSIYDPLGIVAAFVIHGKVLVQE-VWRA-K----------I------ -DWDE-K-IPW--EIFCRWQQWLAVLRKMN---T-VKVS--RCY--F------------- -PGYSIE-CYNSL-DLHI-FVDASEE-AYA-AVAYFR--VVD--NG------RVRC-S-- LVSS---------------------------KTKV-API--Q-P---------------- --------------------------------LSIPRLELLAAV-LGA-RLRQTIEEK-- -H------S-LEI---RRT---FF---------WS------------------------- ---------------S---------------FDPRRTWYLPLGVV-------LNPR-K-P GKV-RIIWDAAAK-V-EG---VSLNSMLLKGPDQL--TSLLSVLFKYR---EREV--AIS GDIREMFHQLLIQEE--DRSALL-----F------LWRNC---P-NS---------P-ID IMVMNVATFGASCSPAQSLFA-MNLN------------A----TEN-EADY--P-RAAAA I-KHR--HYVDDY-LDSVD-T---EEEAAELALEVA-EV-HSKA-------GFEIR-NWL SNRT-TV-LDKI--GE-----VKPGSVKCFGA-----------------------D-KET GT--E-----------------RL--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PF CRPFTMVGIDYFGPYN-------------------------------------------- ----------------------------IRSPTG-R-----C-TL-----KR-WVV---L -FTCLT--IRAVHVEIAANLSTDSC-----KKAIRRF-IGRR-GAPREIFSDNGTNFVGA SGELA-S-E------IRM-INR-E----------------------IS---STFTDIQTQ ----WQFNPPSAPHMGGCWERMVRSFKTALGA-LP--T---V-RLL----DEEAF----- --ATV-----LVEAESMINSRP--------LTF------------I-------------- ----------------------PL-------------ET--------------------- ----------- >1645/1-553 ---PTKRQVLKLVMSLFDPCGFISHFIVHGKILMQR-IWRT-G----------T------ -DWDE-Q-ILP--ELQEMWKDWTQLLKRLD---D-VKIP--RCV--F------------- -GGADSK-LPASI-QLHL-FVDASEL-AYA-CVAYLR--IVQ--AG------TVHC-G-- IIAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAGV-IGC-RLMETICSS-- -L------D-LSI---ESR---HI---------WT------------------------- ---------------S---------------TENNRLWYLPLGVV-------RNPK-K-P QKV-RLIWDAAAR-V-NG---LSFNDMLLKGPDML--TSLFNVLLRFR---QRSV--AIC GDIREMFHQIQIISE--DKQYQR-----F------LFREH---L-DD---------P-PQ IYVMDVATFGAACSPCSSQFV-KNKN------------A----EEF-KANY--P-KATEA I-IKA--HYVDDY-LDSVD-T---VEEAVKLVAEVK-HV-HAQG-------GFEIR-NFS SNSE-EV-LEQL--GE-SQSL----EKKSLSM-----------------------D-ASV YI--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PN IRAFNYTGIDYFGPLL-------------------------------------------- ----------------------------VK--QG-R-----N-LV-----KR-WVA---L -FTCLA--TRAVHLEVVHSLSTQSC-----VMAIRRF-VARR-GSPSAFYTDNGTCFAGA SNLLR-E-Q------LQA-IHE-D----------------------CA---DTFTNARTT ----WHFNPPSAPHMGGCWERMVRSVKMAMMAITE--H---P-RHP----SDEVL----- --ETV-----LLDAEAMINSRP--------LTF------------I-------------- ----------------------PL-------------EN--------------------- ----------- >1648/1-537 ---PTKRNVLSQIAKIFDPLGLISPVVVFAKIIMQQ-IWMS-K----------L------ -KWDD-V-LDG--KLLQAWIMFRDTLSHIH---E-IKIP--RYF--G------------- --AV-N-ST--RY-EIHG-FADASSV-AYG-ACLYIR--VVTQ-DG------VKL--S-- LICS---------------------------KSRV-VPI-------K------------- ---G----------------------------LTIPRSELCAAL-LLV-RLFLKLLPA-- -V-K----L-E-F---QSI---HF---------WS------------------------- ---------------------------------------LPHHAV-------LKPS-SSS TKL-RVVFDASSKT--KG---PSLNDSLMIGPVIQ--NDLFSINLRFR---SHRY--VFS ADISKMYRQIQVDRA--HTPLLR-----I------FWREN---P-TD---------PL-Q VLELTTVTYGTSAAPFLATRA-LQQL------------A----FDE-CTRY--P-YAAQI V-LED--FYVDDV-LTGAE-T---VEEAIQRRVELT-EL-LSCG-------GFPIH-KWC SNEP-TI-LDTVPEKDREKFL------SFE---------------------------D-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VP SPPFSKSGVDFAGPVF-------------------------------------------- ----------------------------IR--QGGRKS---TLV------KA-YIC---L -FVCMS--TKAIHLELVSDLSAAAF-----VAALHRF-VARR-GLVEELFSDNGSNFVGA KSELH-S-------LYQLFKSD-QL------------------QGKLN---EFCHAREIK ----WSFIPPRAPNFGGLWEAGVKSTKTHLKKVLR--D-----ASL----TFEEY----- --YTV-----LTQIEAILNSRP--------LFS------------S-------------- ----------------------SS--------DPS--E-------P-------------- ----------- >165/1-561 ---PTKRQVLRTIMSVFDPLGLVAHFVVHGKLIMQR-IWRA-G----------L------ -NWDE-Q-IDG--EILEDWRKWSGLLTTIA---E-VSVP--RCL--L------------- -PD-SGD-TTQEP-QLHV-LVDASEN-AYA-CVAYLR--TSC--NG------LPRC-T-- LIAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAL-IGS-RLVDTITKA-- -L------T-IPI---SAR---YL---------WT------------------------- ---------------S---------------SMPGRVWYLPLGVV-------RNPR-K-P AKV-RLIWDAAAR-T-EG---VSFNDMMLKGPDML--TALPVVLLRFR---QNRI--AFS GDIKEMFHQFRIRQE--DRQAQR-----F------LYREH---P-EA---------Q-AQ IFVMDVATFGAACSPCIAQYL-KNKN------------A----EEY-KEQF--P-EAAQA I-VDK--HYVDDY-LDSVE-T---LEEAAKLIEDVK-HV-HAMA-------GMEIR-NFA SNST-EL-LQRI--GE-ARKT----EQKSMSL-----------------------E-TS- -A--E-----------------RV--LG-------------------------------- -----MMW---------------------------------------------------- ----------------------------------------------------------PF IRPFTHTGVDYFGPIL-------------------------------------------- ----------------------------VK--QG-R-----S-TV-----KR-WIA---L -FTCLS--IRAVHLEVVHSLSTQSC-----VMAIRRF-VARR-GSPATFCSDNGTNFIGA NNLLK-E-Q------LRT-ISK-D----------------------CA---TTFTNSATK ----WLFNPPLAPHMGGPWERMVRSVKVAMAAIAD--H---P-RHP----NDEVL----- --ETV-----LLEAESVVNSRP--------LTY------------I-------------- ----------------------PL-------------DHATQEALSPNHF---------- ----------- >1650/1-538 -----KRQILQSLASTYEPLGIISPVVLKGKLFFQK-LWN-NS----------G------ -NWDS-P-LSE--DEIKEWKAIETSCCG-E---A-ITIN--RKY--F------------- ---STPNTSEHQF-EIHC-FGDASEA-AHG-AVAYIR--RI-GVHS-------IET-A-- FVCS---------------------------KSTV-SPL--K------KT---------- --------------------------------LSIPQAELVAVE-RGA-RLAHTIQQE-- -L------D-LPIS---MI---VI---------WS------------------------- ------------------------------KPTNTKVHYLSHHPV-------FKL-SSVS TKL-RIVYDASARAN-KN--SQSLNDALHTGEKLL--PKLNGVLMRIR---VPPI--LVS SDIEKAFLMLELHPQ--DRDCCR-----F------LWQ-------------PPGQTQP-V CYRFLRVPFGVKSSPFLLNAS-IKKH------------L-------RSEQS--E-LA-KK I-ALN--IYVDNV-FMGVA-N---AKEGVQFYRESK-KI-FAKV-------QMNLT-QYE SNSK-EL-NEMIGIIEGKAAD--------------------------------------- QKVNL-----------------KL--LG-------------------------------- -----TSW---------------------------------------------------- ----------------------------------------------------------TW SKPFTICGLDYGGPIQ-------------------------------------------- ----------------------------ATNQ-GHN--------------RKYWFI---L -LTCLS--TRFTVVELVPSLDAEHL-----LKVMKRF-ASQY-GTPQTIITDNAAQIKML AQVTE---------EAQ--KQMSS----------------------------MSSSQTLP ---TFKFIPALSPWSGGFYERMIALFKNCLIRAGS------TKTLL----DEEDL----- --RTL-----LKEAEAVVNNRP--------LTY------------V-------------- ----------------------S------------------------------------- ----------- >1656/1-568 ----TRRGILSTVSSVFDPLGCVSPVVLPAKQLLQT-LCRS-Q----------L------ -GWDA-E-IPS--ELMRKWLQWRTELPKLM---Q-FKME--RCL--K------------- -PDGFA---PQSV-TLHH-FSDASEK-GYG-VVSYLR--WEN--ED------EVRM-K-- FLTS---------------------------KARV-APL--K-E---------------- --------------------------------VSIPRMELTAAN-VAV-RIDHMIKQE-- -L------D-IPI---EET---YF---------WT------------------------- ---------------K---------------RDDGRVWYLPHHGV-------VHPQ-K-- KKL-RVVFDCSAE-F-GV---FCLNRELLQGPDLT--NTLFGVLTRFR---QDKV--ALM ADIEGMFSQVRVPKD--DRDLLR-----F------LWWEK---GDIE---------QPLT DHRMKVHVFGAVSSPSCANFA-LKRA------------A----QEQ-ADSF--SNEVTST I-QKN--FYVDDC-LFSTP-S---VQQAVKLATDVT-AA-CEGR-------GFHLT-KWV CNEP-EV-MKTI-------PEKEKAKSVQDLS-----------------------LDHKN -QVTE-----------------RA--LG-------------------------------- -----IIWSTSEDTFGVKI----------------------------------------- ----------------------------------------------------------PD EPPFTKVGIDYFGPLV-------------------------------------------- ----------------------------VK--RG-R-----S-EV-----KT-YGV---M -FTCLA--IRAIHIEKAESLSTDSC-----IAAIRRF-IARR-GTVKEMRSDNGTNLIGA QRELK-R-------EIENWNQA-Q----------------------IS---DAMLQRNIQ ----WTFNPPGGSHHGGVWERQIRTVRQVLFNLVR--Q---Q--RL----DDEGL----- --QTF-----LCEAEGIINGRP--------ITK------------A-------------- ----------------------SN-------------D--------PNDL---------- ----------- >166/1-564 ---PTKREVLRTLMMVFDPLGLISHFLMFLRTLLQE-IWRS-S----------V------ -DWDE-Q-IHD--THFEKWLSWLRILPQVA---S-IRIP--RCY--R------------- -SVTSLE-TGGIV-QMHT-FVDASEN-GFA-AAVYLR--FEE--GS------IVEC-S-- LAGA---------------------------KTRV-APL--K-F---------------- --------------------------------ISIPRSELQAAV-IGV-RLADTILGS-- -L------T-TKV---QKR---FF---------WT------------------------- ---------------E---------------TRHARIWYLPMFPV-------VNPN-K-P GKT-RLVWDAAAT-S-HG---VSLNSVLLKGPDQL--TSLLSVLIRFR---EFRV--AVS GDIREMYHQVQIRPA--DQHCQR-----F------LWKEN---E-AD---------SSPS TYVMQVMSFGACCSPSVAQYV-KNTH------------A----MKY-EHNY--P-EAVHA I-IHQ--HYVDDM-LISAE-T---EDKAIQLADEVK-KI-HESG-------GFEMR-NWV SNST-TV-VAAL--EG---EGAK---EKSMSI-----------------------GEA-N TN--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------VY SRPFSHMGVDYFGPMT-------------------------------------------- ----------------------------VS--IG-R-----R-TE-----KR-WGV---L -VTCLT--VRAVHLEVAHSLSADSC-----IMALRNV-IARR-GVPVTIYSDRGTNFVGS NTELK-A-------ALEVLDQE-Q----------------------LI---KEFTTTHTK ----WSFIPPLSPHMGGAWERLVQTVKQNLGRLRS------N-RRL----TEETL----- --RSM-----LIEVEQIVNSRP--------LTD------------I-------------- ----------------------PL-------------DDDQSPVLTPNHF---------- ----------- >1663/1-545 ---ATKRGILSTVSSLYDPMGLIAPATLHPKLILQE-LCRE-K----------K------ -AWDE-R-IPE--KHVKSWQKWEAELPLLS---HRFEVD--RCV--K------------- -PVGFGD--PASV-QIHH-FADASES-GYG-TASYIR--MENQ-DG------RVHC-A-- LLMG---------------------------KARV-APL--K-K---------------- --------------------------------ITIPRLELNAAV-VAV-RVDSMLKRE-- -L------D-LKV---DRT---HF---------WT------------------------- ---------------K---------------TEPGQVWYVPHHGV-------YHPQ-K-- GKI-RVVFDCAAS-Y-AG---TSLNKELLQGPDLT--STLLGVLTRFR---KEPV--GLM ADIESMFSQVKVPEK--YRDYQR-----F------LWWPK---GNLD---------EPPE EYRMTVHVFGATSSPSCANYA-LKRI------------A----EDC-KGQY--NEEVLKA L-KED--FYVDDL-LKAMP-T---EKQGQCFANEMR-EA-CATG-------GLRLT-KWV SNSR-EV-LKTV-------PTSEMSEEVKDLD-----------------------LD--- ------------------------------------------------------------ ------------------------------------------------L----------- ----------------------------------------------------------PD EPPFTRVGVDYFGPIE-------------------------------------------- ----------------------------VK--RG-R-----S-TV-----KR-YGV---I -FTCMA--TRAVHIEKADSLDTDSC-----ISALRRF-VARR-GQVKQIWSDNGTNLVGA KAEME-K-------EIKKWNER-Q----------------------IS---ETMLKKNVD ----WRFNPPTGSHFGGVWERQIRSIRQVLNAISK--Q---K--LQ----DDEGL----- --RTL-----FCEVEYIINDRP--------ITA------------V-------------- ----------------------S------------------------TDI---------- ----------- >1664/1-577 ---FTRRGVLSTVSSFYDPCGFISPVMLPGKRILQE-MCRS-N----------A------ -DWDT-P-MPE--ALRARWENWLEDVRNLE---G-LQIP--RCL--K------------- -PNGFGK--IKQV-ELHH-FSDASED-GYG-QCTYVR--FINE-DD------NVHC-A-- LVIG---------------------------KSRV-TPL--R-Q---------------- --------------------------------ITIPRLELAAAT-TSA-RMSSFVKEE-- -L------K-YHD---AKD---FF---------WT------------------------- -------------------------------------NYIPHTGV-------YHPR-K-P DKI-RVVFDCSAA-Y-QG---VSLNDHLLQGPNSM--NSLLGVLCRFR---KEEV--ACA VDVKSMFHQFFVSPE--DRDLLR-----F------LWWED---GNPE---------KQVV EYRMTVHLFGAASSPGAATFG-LRKA------------A----EDG-EDEF--GADAAEF I-RKD--FYVDDG-LTSVP-S---TQIAVKLLKDSQ-GI-CAKA-------GLKLH-KVI SNDI-DV-LKSF-------PKEDRSKEVQQLD-----------------------LDKDS -LSLE-----------------RV--LG-------------------------------- -----VVWRIQNDVFNF------------------------------------------- ----------------------------------------------------------EP TPPFTYSAVDYFGPFL-------------------------------------------- ----------------------------VK--ER-R-----S-EV-----KR-YGV---L -FTCMA--SRSVHLETANSLTGSSF-----INALRRF-MNRR-GVVRQLRSDQGTTFIGA RTELR-H-------ALAEMDQS-Q----------------------VQ---EYLLQNGCD -WIPFKMNVPHASHMGGVWERQIQTVRRVLEPLLQ--T---VGSQL----DDEAF----- --RTF-----LTEAEAIINARP--------LTT------------T-------------- ----------------------NL--------S----DSGAPEPLTPNHL---------- ----------- >1668/1-528 ---PTKRKVLSAIARVYDPIGFIAPVILIGKLLMQA-LWKS-K----------L------ -KWDE-K-LDE--YLTLRWKSFLSSLPILH---Q-IRIP--RQM--M------------- --LT-N-AV--GF-ELHG-FADASKV-AYG-ANVYIR--SLFA-DG------SAQM-R-- LVTS---------------------------KSKV-API-------K------------- ---E----------------------------ESIPRLEGLAAL-LLA-RLMRKVLDA-- -IGD----H-H-F---SSI---VC---------WS------------------------- -------------------------------------WYLPHHAV-------LRPS-NTT TKC-RVVFDASAKV--SG---SSLNDVMMVGPTVQ--RDLLSIILSFR---KHQY--VLS ADIAKMYRQILVDPR--HTPLQR-----I------FWRKS---P-SA---------QL-R VLELSTVTYGTAAAPFLATRA-LLQL------------A----RDE-KDRF--P-LAAKV I-EKN--VYVDDA-LFGSN-S---LDEAFEMQFQLI-QL-LKSA-------GMELH-KWS SNEE-LL-MV-------------------------------------------------- ------------------------------------------------------------ --------------------TI-------------------------------------- ----------------------------------------------------------DT APAFQKVGVDFAGPIM-------------------------------------------- ----------------------------IK--QSARRA---VPV------KG-YIC---V -FVCMV--TKAIHLEAVEDLSTEAF-----LGAFQRF-VSRR-GIPEHVFSDNGTNFVGA KSELH-E-------LYLLFQAR-FA------------------QDKIF---DYCHTKEIT ----WTTIPPHAPHFGGLWEAGVKSVKSVLKKVYQ--S-----ASM----TIAEF----- --CTL-----LCQIEALLNSRP--------LFA------------H-------------- ----------------------SS--------D-----------------PQDF------ ----------- >1669/1-530 ---PTKRQLLQVVMSIFDPLGLVSLIVVHGKILLQN-VWRS-K----------I------ -DWDT-K-IDG--NLFGEWYRWAIFLKQLN---T-VHIS--RCY--F------------- -PGYAPE-SYDTL-ELHV-FTDASEE-AYA-AVAYFR--IID--RG------QVRC-T-- LVGA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAL-LGA-RLAKSIEEN-- -H------T-LNI---NRR---VF---------WS------------------------- -------------------------------------WYLPLGVV-------VHPK-K-P GKI-RVVWDAAAT-V-QG---QSLNSVLLPGPDLL--TSLPAVLSQYR---QRQV--AIS GDIQQMFHQLKIRPE--DKQAQR-----F------LFRDD---P-SK---------A-VV TYVLDVATFGATCSPSAAQFI-KNRN------------A----RDF-EDQY--P-EAAHA I-IHK--HYVDDY-LDSLD-T---IDEAVDLAQQVR-TV-HAKA-------GFHIR-NWQ SSSK-EV-LARI--G--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PN VRAFSFVGLDYFGPLL-------------------------------------------- ----------------------------VK--QG-R-----H-EV-----KR-WVA---L -FTCLT--VRAIHLEVVTSLSTESC-----KMAIRRF-IARR-GAPREIYSDRGTNFIGV SGELR-E-K------SRN-INQ-K----------------------LA---ATITNINTE ----WRFNPPSAPHMGGSWERMVRSVKCALAS-LS--S---E-RKP----DEETL----- --ETL-----LIEAEAIVNSRP--------LTY------------M-------------- ----------------------PL-------------DHAENEALTPNCF---------- ----------- >167/1-545 ---PTKRQLLQVVMSIFDPLGLVSLIVVHGKILIQN-VWRA-S----------I------ -NWDE-K-ITS--DLFSEWRRWIKLLGQLD---A-IRIP--RCY--F------------- -PGYHPE-SFESL-ELHI-FVDASEE-AYV-ASAFFR--IVD--RS------QVRC-V-- LVSS---------------------------KTKV-APL--K-P---------------- --------------------------------LSVPRLELQAAL-LGV-RLAKSVAEN-- -H------T-LVI---VRR---FF---------WS------------------------- -------------------------------------WYLPLGIV-------VQPK-K-P GKV-RLVWDAAAA-V-RG---QSLNSALLPGPDLL--TSLPSVLSRYR---QRQV--AIS GDIREMFHQLQIRPE--DKQAQR-----F------LFRSD---P-TK---------E-PD TYVMDVATFGATCSPSSAQFI-KNQN------------A----KDF-EAEY--P-EAAAA I-VHN--HYVDDY-LDSLD-T---IEEAIDLALQVK-TV-HAKA-------GFHIR-NWM SSSK-EV-LSRV--GD-SAEE----QQKSFKT-----------------------H-SAS TS--E-----------------RV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PY VKPFSFVGLDYFGPLL-------------------------------------------- ----------------------------II--QG-R-----H-EV-----KR-WVA---L -FTCLT--IRAIHLELVSSLSTECC-----KMAIRRF-IARR-GAPSEIYSDRGTNFVGV SGELR-E-Q------IRG-INS-D----------------------LA---STFTNTITQ ----WRFNPPASPHMGGAWERMVRSVKCALAA-VS--A---E-RKP----NEETL----- --VTL-----LVEAESVVNSRP--------LTY------------M-------------- ----------------------PL-------------ET--------------------- ----------- >1671/1-548 ---PTKRDVASKLAETFDPLGLVAPIMVAFKRLIQK-LW-SHD----------M------ -NWKD-K-IPV--ELLPDWHNLQKSFQDTL-----VVIP--RQL---------------- ---T-DQYDYDRA-ELLI-FSDASQD-IYA-CMAYTC--FLK-KGC------EPRV-Q-- LLAS---------------------------KNKI-RPSKNE-K---------------- --------------------------------WTIPKLELLGIE-CGS-TLACNIIAE-- -L------R---IKI-NNI---RL---------FT------------------------- -----------------------------------PVYFIPHRAV-------FKE-DSLT TKL-RVVLDASSHAR-GQ---ISLNDCLHAGTNMI--TPIFGILLRTR---CTKF--IIV ADIAKAFHQVKLQEE--FRNVTC-----F------LWLKN---I-HK----HPTEDNI-M VYRSTVIPFGVSSSPFLLAAY-ITYN------------L-------DNNPD--D-IN-KE I-RDN--LYVDNA-LFGTN-D---SEKIMPIIRKTK-AT-FANM-------SMNLR-EYC VNHD-KI-MDTLDTSVA--T---------------------------------------- SAEAI-----------------KL--LG-------------------------------- -----YTW---------------------------------------------------- ----------------------------------------------------------IS SKPFSKVGLDYLGPIE-------------------------------------------- ----------------------------YVKDDGVSIG------------KA-YVL---I -YTCMC--TRGAVLRVVPDSTSYRY-----VMTLKMI-FREV-GVPLAVYSDNAAAFRLG ASVIN-A-------DIAS----------IE-Y-----------STTLT---TFLASESID ----YKFIVPFAPWQGGVYERIVQIVKRQIRKECG--N-----AKF----DFHSL----- --QYL-----VSGAQGMINNRP--------LTP------------H-------------- ----------------------SR--------SPG--D-------M-------------- ----------- >1678/1-549 ---PTKRQVLQTIMKLFDPLGLISHFIVHGKILMQE-IWRS-G----------T------ -NWDE-P-IAE--HLLDQWHRWIELLGLLS---E-VKVP--RCF--F------------- -KGQPSD-SLQGL-QLHV-LVDASEV-SYA-CVAYLR--LNT--TY------GGRC-V-- LVAS---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAL-IGA-RLSQGIKSA-- -L------T-LSI---EKC---YY---------WS------------------------- -------------------------------------WYLPLGVV-------TNEK-K-P DKI-RLIWDAAAK-V-GG---VSFNDFLLKGPDLL--TSLHDVLLRFR---ERSV--AIC GDICEMFHQIRIREP--DKQSQR-----F------LWRNS---S-VE---------P-IQ TYVMDVSTFGATCSPCSAQFI-KNKN------------A----REF-SEVY--P-RAVNA I-IYN--HYVDDF-LDCTD-T---EEEAIELVQNVK-AI-HATA-------GFEIS-KFR SNSA-EV-LSAL--GE-----HYGGQNKLLCS-----------------------D-KQA TS--E-----------------RV--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------PF IRAFTYVGVDYFGPLE-------------------------------------------- ----------------------------VK--VG-R-----G-VA-----KR-WVA---L -FTCLT--VRAVHLELTHSLSTQSC-----IMAIRRF-VARR-GAPREVYTDNGTNFHGA GRRLN-E-EKQ---MLQK-LSE-R----------------------CA---TTFTNANTT ----WYYNVPAAPHMGGPWERMVRAVKTAMKAISE--Y---P-RHT----NDEVL----- --ETV-----LLEAESVVNSRP--------LTY------------V-------------- ----------------------PV-------------EG--------------------- ----------- >168/1-565 ----TKRKILSEISRLYDPLGLIAPIVVRAKILMQQ-LWML-S----------L------ -EWDE-E-VPI--EIQAKWRTFVNELPSLS---N-FRID--RYA--F------------- -----E-EG--DV-QLHC-FADASDV-AYG-ACVYVR--TVGS-GG------AIKV-E-- LLTS---------------------------KSRV-APL-------K------------- ---K----------------------------RSIPRLELCAGQ-IAA-QLTSKVRTT-- -L-E----I-G-A---NSV---WY---------WS------------------------- -------------------------------------CFLPHHPV-------LKES-SST TKV-RGVFDASAKTS-TG---YSLNDALLVGPVLQ--DELYLIVLRFR---RYRI--VLL ADIEKMYRMVRMHPD--DQPLQC-----V------LFRFG---K-DH---------PI-T RYALTTVTYGLSPSSFLATRT-LHQL------------A----DDE-GRSF--P-LAADA L-KQD--FYMDDF-IRGED-S---IPAAIQLRQEMT-KL-LNRG-------GFRLR-KWC SNFH-EV-LDGVPEEDLATQS--N-R-TFD---------------------------P-- -DEAI-----------------KT--LG-------------------------------- -----LSWEPSSDQFRFDINVD-------------------------------------- ----------------------------------------------------------TP SRPFSSTGVDYCGPVL-------------------------------------------- ----------------------------VKSK--IRRS---APT------KA-YIA---L -FVCFS--TKAVHIELVGDLSTQSF-----LSALRRF-IARR-GLPEHIYSDNATNFAGA KHELH-A-------LYQMLNNR-TE------------------NARIA---TSLATNGIN ----WHMIPPRAPNFGGLWEAAVKVAKKHLVRQIG--T-----SSL----LQEDL----- --ETV-----LVQIEGCMNSRP--------LVA------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >1680/1-560 ----TKRNLLRTATSVFDPLGGLTPFTVRAKRMFQS-LWQT-G----------M------ -TWDD-N-LPA--EVVLQXRVWKLELNELP---C-IAMP--RAY--F------------- -QFSPTE--ASRL-ELYG-FGDASEA-AYA-AVVYLR--AVKT-PD------DVQV-S-- FVTA---------------------------KSRV-APL--K-K---------------- --------------------------------LSTLRLELMAAL-LCA-RLVCYVRKE-- -L------A-LDV---EAC---H-----------A------------------------- ------------------------------EGPHGRTWYLPHHVV-------SQQ-GPEA MKH-RIVFVASVKFK-GT----SLKEQLDSGLKLQ--ADLLGILLRFR---RFRV--ALQ SDLAKMFLQVGLFDE--DRGVCR-----F------LWRKD---G-LG--------GPI-A TYRLTRVCFSVACSPYVAMQV-VNHH------------L----REKRDCFG--T-VV-DE I-KVG--MYVDDL-VVSCD-S---IDEARDFAHRSS-EL-LASG-------GFHLA-KWA NNAP-EA-LVDLPAEEIFRDR--------------------------------------- YSCLW-----------------KN--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------NP ARPFSNVGIDFVGPLL-------------------------------------------- ----------------------------IRS-ESS-KY---VSK------KA-YIF---L -FTCMV--IRAIHLELVPDQTIDSF-----LRALRRF-VARR-GRPDTIQSDNFRTFHQA NAFLK-H-------LFSGRN-----------------------WETVQ---RHLASERVE ----WIFITERSPWCGGYWEPLVRSVKTALKATLG--Q-----CLA----APDEL----- --RTV-----LCEIEARVNERP--------LTF------------V-------------- ----------------------GS--------DVD--E-------EMALTPAHF------ ----------- >1682/1-554 ---PTKRELQSFLAKFYDPMGILTPLTVRLKLFLQS-LW-PTK----------I------ -NWKQ-K-IPE--GTEKIWETIRKQFQHQQ-----FTFA--RTL---------------- ---T-QNFDFIRS-KLII-FSDASKN-SYG-LAAYIR--FEY-PDK------TVKT-S-- LIMG---------------------------KSRV-KPLNKDVR---------------- --------------------------------YTIPRLELLALA-TGT-NCAIYIQKE-- -L------H-TNIPF-ESV---EF---------FS------------------------- -----------------------------------RCFYIPHMTV-------VKQ-DSNT TKL-RMVLDASSHMK-NK---LSLNQCIKSSPSII--KLITGILMRCR---AGKF--YMT SDIEKAFHQIRLQKD--DRDFTR-----F------VWVKD---P-SK----GPVTDNF-I TYRFTRIPFGLSCSPYLLAAS-ILTY------------M-------EKYPA--E-IN-KH L-EQN--CYVDNM-MFTTN-N---ESELINMYKESK-EA-AKKW-------GMNLR-EYQ TNSE-ST-SSAIPEMDR--A---------------------------------------- PQKPN-----------------KI--LS-------------------------------- -----HIF---------------------------------------------------- ----------------------------------------------------------QK SRPFERIGLDYFGPIY-------------------------------------------- ----------------------------YK-ANG-VER------------KC-WTL---I -CTCLV--TRNIHLELVSDNGTVEF-----ILAMRRF-FARR-GTPRKVLLDNARTFKLG EKIFN-G-------DIRR----------LGSE-----------CEAFT---TFLDQNPMN ----WDFITPLSPWKGVIYERLIAIVKRLLYSSGD--T-----AKL----NFVQL----- --FTT-----MTEIEAIVNSRP--------ITR------------N-------------- ----------------------SE--------KLT--D-------SPVIR---------- ----------- >1684/1-536 ---TTKRKILSHIAKVYDPLGLISPALLPAKHFLQI-VQN-LN----------F------ -KWDD-P-LPE--KMALDWIKLMHAWDGFGFNFR-VEFP--RHI--A------------- ------TSP--NE-EFHC-FCDASKT-GLG-VALYQL--A-DSSYG------KKES-N-- LIFG---------------------------KSLV-KPL--K---VADHD---------- --------------------------------STIPKLELQALT-LGV-KVTKFVQTQ-- -L------N-FDDQ---QV---IL---------WT------------------------- ----------------------------------------------------------ST TKI-RIVMDASAKPK-STPSAPSLNECLHTGPLLL--KDLTGILLRFR---RMEK--VIL ADIEKAFLQLGVREQ--DRDATR-----F------LWLAN---P-KEANLEQLKREDF-R VFRFCRVSFGLTVSPFLLNAT-IREH------------L-------ALHDT--D-VA-QR I-SDN--LYVDNI-MVEIK-P---SENSNQLVTEAK-II-FESA-------GMRIR-EFF GSHI-DE-LKELDSSEL--AQ--------------------------------------- DLENT-----------------KV--LG-------------------------------- -----IEW---------------------------------------------------- ----------------------------------------------------------NE TRPFNNTGIDYFGPLK-------------------------------------------- ----------------------------VKRGLETV--------------KV-YVA---L -FTCLT--IRAIHLEVAEDYSAEAF-----LRVFRRF-AARR-GVPRVILSDQGTNFIAG AKVIK-E--------------N-WT---TDLL-----------TLEVQ---EQLAHQGIT ----WNFNTAHAPWKGGTWERLIGITKNALRRSIG--R-----RLL----TFDEF----- --GTL-----VVEIEAIVNHRP--------LTF------------E-------------- ----------------------S------------------------------------- ----------- >1687/1-544 ---PTKREVLRVLMTIFDPLGLIAPFLVYLKILLQD-IWRS-G----------I------ -LWDD-K-IND--KSFSKWIIWLRVLPQVE---R-IQIP--RCF--R------------- -LGF-PD-YD-EV-QLHT-FVDASEN-AMA-ATCYLR--FVK--DG------SIRC-S-- QVAG---------------------------KTRV-APL--R-Y---------------- --------------------------------HSIPKLECESAV-VGV-RLARTVTES-- -L------S-FTV---DKH---FY---------HT------------------------- -----------------------------------RSWYLPVFPV-------TNPN-K-P GKV-RMVWDAAAK-S-HG---VSLNSALLKGPDLL--SSLYTVLILFR---ENPI--ALT GDIREMFHQVAIRQE--DQQCQR-----F------YWRDE---N-GQ---------L--A VYAMCVMTFGACCSPSSAQYV-MNLN------------A----DRF-TREY--P-TATEV I-RNQ--HYVDDM-LFSVN-T---EAEAIKIAKDVK-FV-HSKG-------GFEIR-NWV SNSQ-RV-LQAL--LG---DTTE---EKNLDL-----------------------SPE-M TT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AL ARPFTHVGIDYFGPLV-------------------------------------------- ----------------------------VS--VG-R-----R-TE-----KR-WGM---L -ITCLT--TRAIHIEVVHSLSTDSC-----IMGLRNF-SARR-GTPRTIYSDRGTCFIGA KREIH-E-------ATENIKLE-D----------------------VM---KEFVSVETT ----WKFNPPLSPHMGGSWERLIGIVKRNLMAIRP------V-RNP----SDEVL----- --RNL-----LTEIEHTVNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >1692/1-564 ----TMRNIYRVLASQYDPLGVILPYTTRAKVIVQH-LWVK-H----------R------ -DWDD-PQLPG--ELQQEWMKWEEELKYLP---E-VTLP--RCY--Y------------- -PYYMDH-SDVRR-EIHI-FSDASEK-AYG-AVAYLL--TEDH-QG------ELHL-A-- FLLA---------------------------RSRV-APR--K-Q---------------- --------------------------------QSIPRLELCAAL-IGA-QLAKLLVNE-- -L------T-VKL---DKF---TY---------WT------------------------- ---------------K---------------ESTREKWYIPHHMI-------THN----- EKN-RLVFNCSFE-Y-EG---LNLNDSLLPGPVLS--PSLLGVLLRFR---EHCV--AIS GDIRGMFHQVLLLPE--DRPLLR-----F------LW-RD---LRRE---------EPPD TYEWQVLPFGTTCSPCCATFA-LQQH------------V----ALH-STP---DEDVRFS V-NKC--FYVDNC-LQSLP-S---AQEARQLVDKLR-AL-LSSG-------GFDIR-QWA SNKG-EV-ISHL-------PPEARSTKLELWL-----------------------SQDKA -EPRE-----------------ST--LG-------------------------------- -----LSWHCKSDNLGFKH----------------------------------------- ----------------------------------------------------------LF KPAFYSAGMDCFGPLM-------------------------------------------- ----------------------------VT--LG-R-----R-TE-----KR-WGL---L -FKCLT--TRAVHIEVLTSMTSDAF-----LMALRRF-IGRR-GQPAELYSDQGTNFRGG ETELR-E-------TFSTLGSD------------------------LQ---QLLAKQRIN ----FHFNPPASPHFGGVWEREIRSIKMALRTALG--S---E--TV----SEEVL----- --QTV-----LIEVEAILNSKP--------LGY------------V-------------- ----------------------SA-------------DL--------------------- ----------- >1696/1-523 ---PTMRNVYRVLASQYDPIGFIIPYTTRAKVLIQA-LWKK-D----------R------ -GWDT-PIEGN---LLSLWQNWEDELIHLQ---E-VTLP--RCY--F------------- -PRNVSS-LSAAV-DLHI-FCDASEE-AYG-SVAYLR--VEDE-QG------HIHV-S-- FVMA---------------------------RSRV-APK--K-Q---------------- --------------------------------LSMPRLELCAAL-TGA-QLARVLQTE-- -L------S-LSV---RQT---IL---------WS------------------------- ---------------A---------------NKTPESWYIPHHMV-------YHD----- RKA-RVVFNCSYR-Y-QQ---ACLNDNLLPXPTLG--PSLLGVLLRFR---EHAV--AIS GDIKAMFHQVRLLPE--DQPLLR-----F------LW-RN---MERE---------RSPD IYEWRVLPFGTTCSPCCAIYA-LQRY------------V----RDH-KVG---NEDVMES V-LHS--FYVDNC-LQSFH-T---TNQAKEFPNKLX-AF-LAAG-------GFEIR-QWA SNVP-DV-ITH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LF KPPFWSTGVDCFGPYH-------------------------------------------- ----------------------------VK--IG-R-----R-HE-----KR-WGI---V -FKCQT--TRCVHLDLLCNMDTDSF-----LLALRRF-VARX-GKPYELLSDQGTNFRGG ERELQ-E-------AFASLTPE------------------------LQ---EQLAKQKID ----FKFNPPHAPHFGGAWEREIKSIKASLQVVLK--D---T--IL----PEEVL----- --RTV-----LIEVEGIMNSKP--------LGY------------V-------------- ----------------------SS-------------DV--------------------- ----------- >17/1-547 ---YTKRILLKKMATLFDPLGFLAPYIIRIKIIMQE-LWID-G----------I------ -EWDD-A-VPD--RIANNVDQWFQELNDLP---K-INIP--RCL---------------- --QTTST--VTNR-SIHV-FTDASCK-AYG-AVAYQQ--CLYD-TG------EVTC-V-- IIMS---------------------------KARV-SPL--Q-S---------------- --------------------------------ISIPRLELLGAV-LGL-RLAEKIVKA-- -L---------KLET-KDV---TI---------WC------------------------- -----------------------------------DGWYLPHFPI-------LRPD-KST TKV-RIVFDGSAK-Y-NG---KSINDVIYQGPKLQ--QDLVTVLLRFR---KYPV--ALA CDIAEMYLKIGIHKD--DQRYQR-----I------LWRNL---D-ST---------AEPE VFQFNRLVFGINSAPFMAQFV-TQEH------------A----RKY-AKKF--P-LASEA V-LEA--TYMDDT-ITSVV-D---EKVGIQLYKELT-LL-WGSA-------GMFAR-KWL SNSV-EV-LKIT---------PENDRAEHINL-----------------------DSGEL PA--M-----------------KT--LG-------------------------------- -----VVW---------------------------------------------------- ----------------------------------------------------------EP LRAFARIGIDFAGPFL-------------------------------------------- ----------------------------TMQGRG-K-----I-RQ-----KR-YLC---L -FTCLL--SRAVHLEMAYNLDTNSF-----LNAFYRM-VNRR-GLPLEVLTDNGTNFVGG CRELN-E-------IVNDLDKD-K----------------------IT---NSTADKGIK ----WHFNAPLGPHLGGVFEIMVKAVKRAMTGILE--K-----ADI----TDEEL----- --CTA-----FTGAESLLNSRP--------LTY--------------------------- ----------------------QS--------K--------------------------- ----------- >170/1-552 ---CTKRQVLSDVSRIFDPLGLLAPIVVQFKILFQQ-LWLL-D----------L------ -GWDD-K-LPK--QLADNWLKWRADLDMLQ---H-IQIP--RLV--V------------- --NDTD-----NI-ELHG-FSDASTK-AYA-AVVYSR--VINK-DG------SIST-S-- IMAA---------------------------KSRV-APL-------K------------- ---Q----------------------------QSLPRLELCAAL-LLS-QLIRSIKAA-- -L-R----H-Q-K---VTV---FA---------WC------------------------- ------------------------------EVNNAQRFYLPHHPV-------L------G RKL-RVVFDGSFCDT-KG---KSLNDYLFTGPSIQ--RDLFAVCLRFR---MYKF--VFS ADIVKMFRQIWVNNK--HRDFQR-----I------VWRER---P-SD---------PI-K HYQLCTVTYGTSCAPFLAVRV-LEQL------------A----TDH-QQEF--P-NAAKI L-QED--FYVDDV-LTGSN-S---EEELIQNRKELI-QL-MSCA-------NLELG-KWV SNTP-RI-PTE-GTDS------TQS----------------------------------- --SPV-----------------KV--LG-------------------------------- -----LYW---------------------------------------------------- ----------------------------------------------------------TQ ALPFVNTGCDYAGPIL-------------------------------------------- ----------------------------LKDG--KGRK---PRIG-----KG-YIC---L -FVCLV--TSAIHLELVTDLSTDSF-----LAALRRF-VSLR-GKCNKIYSDNGTNFIGA KRSLD-E-------MQKLLASQ-PH------------------IEKVR---NTLANDGIQ ----WVFIPPHAPHWGGKWESAVRCVKLHIRRVIG--K-----STL----TYEQM----- --RTL-----LAQVSAVVNSRP--------LCY------------I-------------- ----------------------SD--------TD-----------VNYLSPAHF------ ----------- >1702/1-546 -----RRTVSSVIHGIFDPLGSLAALVLPMKLFQRE-LWMD-E----------------- YDWDT-P-LNK--EHEIQWQQLVEDIQGFS-----KRIP--RHV--I------------- -SKSLNN-------KLVT-FTDASKE-ATA-WTIYVV-------NE-------MGC-H-- LIYA---------------------------KSKV-KPLKEI------------------ --------------------------------WTIPKLEMQALE-MGT-VNTLKTIEF-- -LKLGNINV-------TEI---NI---------FT------------------------- ---------------------------------------NPHQPV-------FTP-TKTT TKC-RVVVDGSAHFK-NK---PSLNDQIHQGPTIL--PDLMGMLLRFR---SGKT--AVT SDVEKAFLQVYLHED--DRDATR-----L------LWVKD---I-NK----DFSGDNI-M VLRFTRVLFGLNVSPFLLAAT-INHH------------L------ETINDQ--D-MA-RE M-SNN--LYVDNL-LMTTDMD---PRNIIKLYSCPK-ET-FNEM-------GMNLR-EFT TNSK-EL-REMIPEKDA--S---------------------------------------- EETTP-----------------KV--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------KK TRPFGNIGIDGFGPID-------------------------------------------- ----------------------------YKGP-DGTTQ------------KA-YGI---I -YVCMV--TRATHIEVVTDQRASSF-----LQSLRRF-IGIR-GMPTKILTDNGTNFTLG SKIVK-D---------AI--D-------SSDL-----------TEEVL---NFLRIRDIE ----WKFITPLSPWKGGMYERMVKIAKQSFMKERR--L-----QKL----NLEEL----- --QTV-----FHEVAAMMNDRP--------LTY------------P-------------- ----------------------DN--------EMG--T-------QNPIRPSDF------ ----------- >1704/1-532 -----KRIVLRQLASMFDPLGLASPSLLSAKLFFQS-LWT-KE----------N------ -KWDD-K-ISE--EKVKKWKEITDSWAI-N---P-IEIN--RRV--T------------- ------EIKSE-K-QLHV-FSDASKC-AYA-ACVYIK--SQFKEK--------IYT-Q-- ILYA---------------------------RNRL-KPR--K----AE------------ --------------------------------VTIPRMELLGVV-IAK-RALEFVEKQ-- -I------G-VEIK---EK---FL---------WC------------------------- -------------------------------------------PV-------VNT--K-- -KV-RIVYDASAKMR-EG---KSLNECLYRGPIIM--PDLAGLLIRFR---VPKI--AMW ADIEKAFHTLELEEE--DREVTK-----F------IWVKD---T-QK----PRSTQNI-Q YFRFAKVPFGVISSPFLLSAT-VRHH------------L------EKCDD---P-VA-KI A-KEN--SYVDNI-FIGVE-S---TSEAWLAYKTLK-KI-FKDA-------QMNLR-EFV SNDI-EL-NEQFPVEDR--L---------------------------------------- EKNKP-----------------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------RQ SRPFEFVGVDYLGPSI-------------------------------------------- ----------------------------CKI--EGSKV------------KF-WIA---L -FTCLS--TRGIHLDLVTDLSALSF-----LNILRRF-VALR-GAPVKIISDNGNQFIVI AKVIN-A-------IIEGKWKK-EK---TKND-----------EKVFN---NYLIEKEIE ----WKFIPALSPWQGGVYERLVKLVKDCFKRSLG--S-----LIL----NLEEL----- --RTF-----IKEVEMSINCRP--------ISH------------I-------------- ----------------------SV--------E-K------------------------- ----------- >1706/1-574 ---TTKRIVVSEMAQLFDPAGWMGPVLMSVKIFVQH-LWAT-N----------K------ -GWDD-P-LSP--EDDRWWKDFRREIPMLQ---Q-VEVP--RRV--I------------- --GN----TTRNY-KLHC-VCDASTK-GYG-CSVYVV--GPDE-KG------KMQS-R-- LLIS---------------------------KSRV-APV-------C------------- ---G----------------------------QTVPRLELCAAL-LGA-ELVNLLLET-- -T-D----F-V-----GPV---TF---------WS------------------------- ------------------------------SRVAGPQFFLPHHAI-------QRPG-SST TKT-RVVFDGSAKGS-GR---FSLNSILHTGPTVQ--PPLLSTILNFR---LPKF--AFT ADAEKMFRQVWVHPE--DRKWQQ-----I------IWRKN---P-TE---------TL-Q IYQLKTVTYGLASSPFHAARV-LNQL------------A----EDE-GHRY--P-IGAQI V-GKR--FYVDDV-LAGAD-T---LEDADEACHQVR-EL-FQLA-------GFSLR-KWS ASHP-DI-LQRIPQDLWESSP------TKE----------------------------IG EPDFA-----------------KA--LG-------------------------------- -----LLWDPRADCFRFKIPTF-------------------------------------- ----------------------------------------------------------TP TRVFANSGLDYCGPFL-------------------------------------------- ----------------------------VRPL--YGRG---ANV------KM-YVA---V -FVCLS--VKAVHLEVVPDLTTTAC-----INGIKRF-VGRR-GRLIELRCDNATAFVGA DRELK-E-------LRKRYLEQ-FR------------------TAEWE---NYCLDSGIT ----FRFIPPRSPHFGGLWEAGVKSFKHHFRRIFG--G-----RSC----TVDEL----- --TTA-----VVHIESILNSRP--------LTP------------L-------------- ----------------------TD--------HPD--D-------L-------------- ----------- >1709/1-533 ---PTKREVVAFLAMNYDPTGLIAPIVVPVKKFITL-LW-NPD----------L------ -KWGD-R-IPD--ILMPMWTAITKVFTVNT-----YTIP--RQL---------------- ---V-TTYDYTHV-DLVV-FSGASQD-HYA-AAAYLR--YDY-QGK------HYQS-Q-- LIFS---------------------------KSRI-KPGRNG------------------ --------------------------------ITIPQLELLALQ-TGT-NVALNLIEE-- -L------H---MPI-RKV---TF---------FS------------------------- -------------------------------------YYFPHRDV-------IKE-DSNN TKT-RIVLDASSHEK-GK---LSLNDCLHPGPSIL--QKIMGILIRSR---LSKY--LMI SDIEKAFHQVRLQKQ--CRDVTR-----F------LWLKD---P-EL----DATPDNI-V TYRFTRLPFGVTSSPFLLAMT-ILQY------------L-------EFDPD--P-IN-AR I-IEN--LYVDNV-LLTTN-D---PVELASLYTKLK-EV-FQKM-------HMNLR-EFL CNNS-EV-M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------KL----------QL VAPFAFVGLDYFGPLR-------------------------------------------- ----------------------------YK-TKE-DNG------------KI-WVL---L -VTCLV--TRAVHLEIVQDNTTHSF-----ILALKRY-FGRR-GVPQSILSDNAPAFKLG YNIMN-T-------DIKS----------LINT-----------SMTLT---SFLADKEID ----IRLITPFSPWKGGIYERLVALVKNMLHKILG--K-----ITI----PFLEL----- --ESL-----IIESEGILNSRP--------ITA------------N-------------- ----------------------KI--------HVA--D-------AKPIRPVDY------ ----------- >171/1-573 ---PTKRVVSSCVMSLFDPQGFLISFTIFGRILIQD-LWRA-G----------C------ -DWDK-A-VDD--EAWEKWKRWVSRLQEVE---G-VRIP--RYY--F------------- -QGAHDL-NYETL-ELHV-FCDASQC-AYG-AVAFFW--IMSS-MG-------PIC-A-- LVSG---------------------------KSKV-APL--K-L---------------- --------------------------------LSIPRLELQSDV-VGS-RLMNFVQEN-- -H------T-LKI---AER---FI---------WS------------------------- -------------------------------------WYLPLNVV-------THPK-K-P EKV-RLVWDAAAT-V-AG---VSLNSQLLKGPDML--TSLPSVIFRFR---ERPV--GFG GDIREMYHQLRIRKE--DTNAQR-----F------LFRND---P-TA---------E-PE VYIMDVATFGATCSPCAAQFV-KNKN------------A----EEF-SKQY--P-AAAKA I-VEN--HYVDDY-YDSAS-T---VDEAIQRAKEVR-LI-HSKA-------GFEIR-NWV ASSS-EV-VSAL--GE-----KEADQKVHLSQ-----------------------N-KTT GY--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PH QRAFSYTGVDYFGPVA-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WVS---L -FTCLT--TRAIHLEVVHSLTTQSC-----VMAIRRF-ACRR-GMPIEFFSDNGTNFQGA SKEI-----------V-R-VDA-E----------------------CR---EEFTDARTS ----WNFNPPSAPHMGGAWERLVRSVKEALKA-FD--D---G-RKL----TDEVL----- --LTS-----LAEAEDLINTRP--------LTY------------L----STEAGSTEAL TPNHFLRGVTANDGAQRAESTSPA-------------EA--------------------- ----------- >1711/1-547 ---PTKREIARVVMSFFDPLGFIAFFLVHGKAILQD-TWVK-G----------T------ -EWDQ-K-IPE--DLNERWRQWSGLFHQLN---Q-LHIP--RCY--F------------- -RSSFPK-NLDAL-QLHL-FVDASEA-AYA-GVVYFR--LES--EK------GVQV-S-- LVGA---------------------------KVKV-APL--K-T---------------- --------------------------------LSIPRLELKAAV-LGI-RLQEAIQSQ-- -H------T-FPI---SRR---FC---------WS------------------------- -------------------------------------WYLPLGVV-------INPR-K-P DKI-RLIWDAAAK-V-GN---TSFNSRLLKGPDLL--SPLPRVLYKFR---QHPV--AVC GDIMEMFHQIRIRSP--DCQSQR-----F------LFREH---S-SD---------S-PQ VYVMDVATFGSTCSPASAQFI-KNLN------------A----DEF-ASEY--P-RAAVA I-KFH--HYVDDY-LDSFE-S---VTEAVTVVNEVK-LV-HSKG-------GFTLR-RFL SNEA-EV-LQKI--GEF----SEQA-PKNLDL-----------------------E-RGG KS--E-----------------SV--LG-------------------------------- -----IKWMPFED----------------------------------------------- ----------------------------------------------------------SF IRPFTYTGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-HA-----KR-WVA---L -FTCLT--IRAIHMEVVHSLSTESC-----IMAVQRF-VSRR-GIPTEFWTDNATTFQGT SNEIK------------A-TKQ-A----------------------LA---QKFTTTQTT ----WKFIPPASPHMGGAWERLVRSVKQTIGTVLD--E---S-RKP----DDETL----- --ETV-----LLEAEAMINSRP--------LTF------------I-------------- ----------------------PL-------------ES--------------------- ----------- >172/1-546 ---PTKREVLKVVMSLFDPLGCISFFLVHGKVLIQD-TWIS-K----------I------ -GWDD-P-IGD--SSLERWKQWTGLFGQLP---S-LRIP--RCY--F------------- -REPFPR-NFDQL-QLHV-FVDASES-AFS-SVAYFR--LPV--GE------QIQV-A-- MVAS---------------------------KTKV-API--N-T---------------- --------------------------------ISIPRLELKAAV-LGT-RLLESIRAH-- -H------T-IPI---AES---FL---------WS------------------------- -------------------------------------WYLPVGVV-------VNPK-K-P NKL-RLVWDAAAK-V-GD---VSFNSNLLKGPDLL--TPLLAVLSRFR---QYPV--AVT GDIKEMFHQIRIRKE--DQQSQR-----F------LWREN---P-TE---------M-PQ IYVMEVATFGSTCSPASAQFV-KNLN------------A----KEF-ANQY--P-RAAAA I-HDN--HYVDDY-LDSFQ-T---IEEAVQVVEEVK-FV-HSMG-------GFELR-NML SNSV-EV-LRRI--EQR----PGES-SKDLLV-----------------------T-RGE ST--E-----------------SV--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------SF VRPFTHVGLDYFGPVF-------------------------------------------- ----------------------------VK--VG-R-----S-QA-----KR-WVA---L -FTCLT--IRAVHLEVVHSLSTVSC-----IMAIRRF-VSRR-GTPAEFYTDNGTCFQGA SKELA-R-E------IQS-RNE-A----------------------IA---LTFTSAHTK ----WHFIPPSAPHMGGAWERLVRSVKAAIGTILD--A---P-RRP----DDETL----- --ETI-----LFEAEAMVNCRP--------LTY------------M-------------- ----------------------PL-------------ES--------------------- ----------- >1723/1-544 ---PTKREVLRTLMLIYDPLGLIGNFLMFIKILLQE-IWRS-G----------Y------ -SWDQ-P-IDA--GCAERWRKWIHVLPTIQ---S-VMVP--RCY--R------------- -LTTSAA--TPNI-QLHV-FCDASEY-GMA-AVAYFR--FEE--DN------VIEC-A-- LIGS---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRLELQAAV-IGA-RLATSIAAS-- -H------R-LKI---GQR---VF---------WT------------------------- -----------------------------------RDWYLPIFPV-------FNAN-K-P GKL-RMVFDAAAK-V-HG---ISLNSFLLSGPDQL--SGLVGVLYKFR---EYRV--AVA GDIREMFFQVNMKIE--DQRSQL-----F------FWGED---ETQH---------AEPS TYAVTVMTFGATCSPGTAHYV-KNIN------------A----DRF-SQQF--P-RAAEC I-KHE--HYVDDM-LASVE-T---SEEAAQLAKDVR-YI-HAQG-------GFEIR-NWV SNSK-EV-LEQL--RW---GVNN---EDSKGM-----------------------DLESS SA--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------VA QRAFTYTGLDYFGPMY-------------------------------------------- ----------------------------VV--VG-R-----R-TE-----KR-WGA---I -FTCLT--TRAIHLEVAHSLNTSSC-----ILAIRRF-VARR-GSPREIISDRGTNFVGA SRELK-E-------DISKVNVD-E----------------------LI---LQFSSSTFR ----WTFNPPAAPHFGGCWERLVRSVKRVLNEFNL------P-RLP----SDEVL----- --QST-----LSEVEMIVNSRP--------LTY--------------------------- ------------------------------------------------------------ ----------- >173/1-542 ---FTRRGILSVINSIYDPLGFAAPVVIKGKCLMRE-LTHA-V----------K------ -HWDQ-P-LSE--KERSIWEKWTSSLIALE---Q-VGVF--RKY--V------------- -PVS-GN--LKQL-QLHV-FSDASNK-AIA-AVAYLR--VLQG-D-------QPYL-G-- FVMG---------------------------KAKL-TPL--H-G---------------- --------------------------------HTMPRLELCAAV-LAT-QLVEIIKRE-- -I------D-LSF---SDI---TL---------YT------------------------- -------------------------------------WYLPFFGV-------YHPQ-K-P QQV-RVVFDSSAL-F-KG---TSLNKVLLTGPDLI--NNLLGVLLRFR---KEAV--AIM ADIQQMFYSFWVRND--HRDFLR-----F------LWFKD---PQQM---------SEIQ EYRMCVHVFGNSPSPAIANYA-LKRT------------A----QLL-EHEY--GSEVCEF V-CRD--FYVDDA-LKSTS-T---PQEAIYLLKKAK-QM-LATA-------NIKLH-KIV SNCL-EV-LLAF-------PKEDRAKGMETLE-----------------------LGQEF ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TI QPPFTNVGVDIFGPWE-------------------------------------------- ----------------------------IV--TR-RTRGGVV-NN-----KR-WAV---M -FTCLS--LRAVHIELVESMDSTSF-----IYALQRF-FAIR-GPVKLLRSDCGTNFKGA CKDLE-C-------PERSVLDP-D----------------------VQ---VFLKQEGCK ----WLFNPPHASHMGGAWERMIGIVRRILDAMLL--NV----TIL----THEIL----- --VTL-----MAEVMSIINSRP--------L--------------T-------------- ----------------------PI-------------ST--------------------- ----------- >174/1-538 ---FTRRGVLSIVNSVYDPLGLAVPVMLEGRKMLQK-LVLMGKRRSKDDSP--L------ -AWDD-P-LPT--AMKDRWARWKDSLPDLQ---N-VSVP--RCH---------------- --HPKMFGTVSTA-ELHA-FSDASQD-AIG-TAVYLR--LVNE-AK------KVSV-S-- LVYG---------------------------QARV-APA--N-S---------------- --------------------------------TSIPRLELCGAV-LAV-QAVQKVMRE-- -I------D-IEI---SQV---KY---------YT------------------------- -----------------------------------S-WYLAHFAT-------YHNT-K-- HTI-RVVFDSSCE-F-QG---ISLNKVLLPGPDLM--NNLIGVLMRFR---KENT--GVM CDVEQMFHSFHVEPS--HRDFLR-----F------LWFEE---NNPE---------KPVT EYRMNVHLFGNGPSPAITTYG-LRRT------------A----SDG-EEEY--GEESKNF I-RRN--FYVDDG-LASLP-T---AQQAIELVKKAQ-AT-LATA-------NLRLH-KVV SNSV-EV-MEA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EV CSPFTNVGFDVFGPWS-------------------------------------------- ----------------------------VK--SR-KTRGAIA-NA-----KR-WGL---V -FTCLS--SRAIHIEVLESMDTSAF-----ICALRRF-FALR-GPAKLLRCDCGTNFVGA KTELD-S-------AMKELNKE-D----------------------AE---RFVREQGCE ----WIFNPPHASHFGGVWERQIRTIRRVLDGMFA--EL--GDHQL----THDLL----- --VTL-----MAEVAAIVNARP--------ISA------------V-------------- ----------------------PM-------------DA--------------------- ----------- >175/1-551 ----TKREILRESSKIYDPLGLITPISIRAKILIQD-LWKL-N----------V------ -DWDE-P-LNG--EIRTRWLSIAQEIRQST---N-LIIP--RCY--L------------- -SNRS---ANETT-QLHV-FVDASPK-AYG-AVAYIR-------QP-------NQT-S-- FVMA---------------------------KSRV-AQV----KE--------------- --------------------------------LSLPKLELMAAL-AGA-NLAEYLLNS-- -L------Q-KNFPD-LQA---FF---------WS------------------------- ------------------------------PDPSDHAHYIPHHHV-------KKE--SST TPI-RIVFDCSCHQA-PS--TPSLNDCLEVGSPYL--ADMGSILVRFR---AHPI--GIS TDIEKAFLHVRLSEA--DRDMTR-----F------LWLSD---P-GD------PESEF-Q TYRFKSVLFGSASSPFMLNAV-LQTH------------L------DNH-KT--P-VT-QD M-RDN--LYVDNI-ITGCE-T---HQEALSYYDESR-SV-MTEA-------KFNLR-SWA SNSQ-PL-LHRAALDGVNDA---------------------------------------- NCDSV-----------------NV--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------RE SRPFAVTGVDFTGELY-------------------------------------------- ----------------------------IRN-----GK---TDS------KA-YIC---L -FTCAA--TRAVHLEVVSDLSVKTF-----ILAVRRF-ASRQ-SIPDVIISDNASTFQSA AAELE-H-------LFNS--------------------------PTLK---QELGKQGID ----WKFIPKRAPWYGGFWERLIGLTKTTLKKVLG--R-----ASI----NLVTL----- --QTV-----VMEIEAILNDRP--------LTY------------V-------------- ----------------------SP--------DIN--D-------EDPLTPSHL------ ----------- >176/1-563 ----TKRQVLCYIAQLFDPLGLLGATITAAKIFMQR-LWAM-K----------N-EANQS LQWDD-P-LPV--TVGEEWRTFHKQIPVLN---E-IRIQ--RCV--V------------- --VP-E-AV--SI-EFHC-FSDASIL-AYG-TTIYVR--SERQ-DG------TVSV-H-- LLTS---------------------------KSKV-APL-------K------------- ---V----------------------------QSLPRLELCGAL-LAA-QLWEKVAES-- -L-K----A-K-----GSV---WF---------WT------------------------- ------------------------------EEETVKRCYLPHHPV-------IKES-STT TKV-RVVFDASCKTS-SG---ISLNDALYAGPVVQ--QDLRSIVLRSR---IRQV--MVV ADVEKMFRQIWTNTS--DTPLQC-----V------MW-FE---P-DG---------SV-V TYELLTVTYGTKSAPYLATRT-LKQL------------A----DDE-RERF--P-LAVSA V-QED--VYMDDV-ISGAD-D---VDSAVELRRQID-AM-TSSG-------GFKLR-KWA SNSP-TV-LEGIPKENLALPD--G-I-NWD---------------------------Q-- -DAEV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV SRPFSKTGVDYFGPVY-------------------------------------------- ----------------------------LRAG--RGRQ---P-T------KA-YVA---I -FVCMA--TKAVHMELVSDLSTERF-----LQALRRF-IARR-GRCSDIFSDNGTNFVGA SNQLR-E-------LAKLLKEK-EH------------------REKVS---KECANEGIY ----WHFNPPNAPHFGGLWEAAVRSAKFHLLRVLG--G-----NPV----THEDF----- --VTL-----LAQVEACMNSRP--------LTA------------L-------------- ----------------------SN--------DPQ--D-------L-------------- ----------- >177/1-550 ---PTKRQVLRTVMKVYDPLGFVAHFVVHGKILMQE-IWRS-G----------T------ -NWDE-P-IAE--HLLELWNRWIELYESIN---E-VKVP--RCF--F------------- -GDLKPE-RVDEI-EIHV-FTDASVA-ACA-CVAYLR--MST--KE------GKWC-S-- MVAA---------------------------KTKV-APL--R-T---------------- --------------------------------LSIPRLELQAAM-MGS-RLLHNICSA-- -L------T-LNI---RKR---FL---------WT------------------------- -------------------------------------WYLPLGIV-------TNPK-K-P NKI-RMIWDAAAK-V-DG---VCFNDMLLKGPDLL--VPLVEVLLRFR---EGKI--AIC SDIREMFLRILIRDE--DKWSQC-----F------LWRNS---P-DE---------V-VE TYVINVAMFGATSSPCTAQYT-KNKN------------A----LDF-VEQY--P-RAVNA I-LKG--HYVDDF-LDSVN-T---VEEAVRLFKEVQ-FI-HSAA-------GFEFG-KIL SNSP-KV-LAQL--GE-----TSPAASKPLNL-----------------------G-KDA VC--E-----------------RV--LG-------------------------------- -----VVW---------------------------------------------------- ----------------------------------------------------------PF IRPFTFVGVDYMGPFM-------------------------------------------- ----------------------------VK--VG-R-----S-SV-----KR-WIC---L -FTCLT--IRAIHLELVHTLTATSC-----VMAFRRF-VSRR-GAPLEVFTDNGTNFVGA HRQLT-E-EKQ---KILK-INN-T----------------------CA---STFTNAHTQ ----WHFNVPAAPHMGGPWERMVRSVKTAMQALSN--N---P-RHP----SDEAL----- --ETI-----MLEAEGIVNSRP--------LTY------------V-------------- ----------------------SL-------------EDA-------------------- ----------- >178/1-544 ---YTKRTVLSTIAQLYDPLGLLSPIIVQAKILLQE-LWAN-K----------L------ -GWDD-E-LPR--QLCDKWEEFCEQLPMLA---R-FKIP--RFA--L------------- --TP-N-YN--YV-ELHC-FADASEA-AYG-ACAYLR--SQSI-DG------TTQV-T-- LLAS---------------------------KSRV-APL-------K------------- ---P----------------------------LTIPRLELCAAL-LAA-RLQQKLISA-- -I-D----M-A-V---NET---HM---------WS------------------------- ------------------------------EDSMAAVHYLPHHPV-------VKES-STT TKV-RVVFDGSAKTT-TG---HSLNDVLHVGPVVQ--DELLSLVVRFR---KYKV--AVI ADIEKMYRQVSMHPD--DRRLQR-----I------FWRFQ---E-TE---------VV-Q TFELATVTYGLAPSSFLATRT-LLQL------------A----EDE-GAPY--P-LATEA V-KKN--LYVDDL-ISGAE-S---IEQAIQLRDELT-SL-MSKG-------GFRFR-KWC SNEL-SV-LDGLTPDLLGTTA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TA NEAFVCTGVDYCGPIM-------------------------------------------- ----------------------------LKPV--HRKA---APQ------KA-YLC---I -FVCMS--TKAVHLELVGDLSTSGF-----LKALDRF-IFRR-NKPNHIYSDNGTNFVGA KNALH-Q-------VYQMLHDE-AQ------------------NRQIN---NYLAEEGIE ----WHLIPPRAPNFGGLWEAAVKVAKKLLVRQLG--V-----SLL----SYEDL----- --ATV-----LIKIEGCMNSRP--------LTP------------L-------------- ----------------------SN--------DPN--D-------L-------------- ----------- >179/1-545 ---PTKRQLLSLVMSVFDPLGMVAPFVVHGKTIVQE-VWRS-G----------I------ -SWDE-P-LPA--DIVHRWEQYAKLLGTMH---T-VKIP--RCY--F------------- -PGYNPE-AYDSL-ELHV-FVDASSS-AYA-AVAYFR--IVD--CG------KVRC-S-- LVSA---------------------------RTKV-API--K-L---------------- --------------------------------LSVPRLELQAAV-IGA-RLAKSVISK-- -H------S-LKI---KRK---TL---------WS------------------------- -------------------------------------WFLPLGVV-------VNPK-K-P EKV-RVVWDAAAS-V-EG---VSLNSVLLKGPDLL--TSLQAVLCRYR---QKAI--AIS GDIMEMFHQVLIRVQ--DRTAQW-----F------MWREN---P-SD---------P-IQ VYVMDVATFGSTCSPSSTQYV-KNLN------------A----EEY-AAEF--P-RASEA I-KEN--HYVDDY-LDSVD-T---VEEAVQLALDVK-EV-HEKA-------GFLIR-HWM SNSP-EV-LTRI--GE-QNTK----SVKSFTM-----------------------D-KGS NL--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PY VRAFTFTGLDYFGPIN-------------------------------------------- ----------------------------VR--FG-R-----G-SV-----KR-WVA---L -FTCLG--TRAVHLEIAYSLSSESC-----KMAIRRF-IARR-GAPQEIYSDQGTNFQGA SAELR-Q-Q------IEA-VNR-G----------------------LA---ETFTNVETQ ----WKHNPPYAPHMGGVWERLVRSVKSGLAY-MG--M---P-RIP----KEETF----- --ITA-----LAEVESTVNSRP--------LTY------------L-------------- ----------------------PL-------------ES--------------------- ----------- >18/1-560 ---PTKRELLSQLSRIYDPLGLVAPVTVLLKLIFQE-SWTS-V----------L------ -QWDD-P-IPE--SLRTRWRALVEDLPALT---Q-CQVP--RYI--A------------- --SPFR-----DV-QLHG-FADASSH-AYG-AVVYAR--VAVG-C-------SFQV-T-- LVAA---------------------------KTRV-API-------K------------- ---P----------------------------VSIPRLELNAAL-LLS-RLLSIVKTS-- -L-T----I-P-L---FST---SC---------WT------------------------- ---------------------------------------LPHHAV-------IKLD-KLT TKC-RVVFDYSGKXS-SG---VSLNDRLHKGPPIQ--RDLLGICLRFR---EHQY--VLC ADVEKMFRGIXIFKP--HTXYQR-----I------VWRKT---E-NE---------PL-L HFRLLTVTYGLAPSPFLAVRV-LKQI------------A----DDH-GHEY--P-AAAHA L-LHD--AYVDDI-PTGAR-T---XEELMILKDELI-AL-LDKA-------KFKLR-KWS SNSW-RL-LKSLPEEDKCKEPIQLLNKSAA------------------------------ -DSPV-----------------KV--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------QA SRCFQHTGLDYAGPIA-------------------------------------------- ----------------------------IKES--KGRT---PRIG-----KA-WFS---I -FVCLT--TKALHIEVVSELTTQAF-----IAAFQRF-IARR-AKPTDLYSDNGTTFHGG KQTLD-D-------MRRLAIQQ-AK------------------DEELA---GFFANEGIS ----WHFIPPSAPHFGGMWEAGVRSIKLHMKRILG--S-----KAL----TFEEL----- --STV-----LTQIEAILNSRP--------LCP------------T-------------- ----------------------GD--------NS-----------LDPLTPAHF------ ----------- >180/1-565 ----TKRKVLSTIATLFDPLGLIGAAITSFKVFMQQ-LWTL-E----------S-EDGRR LDWDQ-P-LPH--TVGETWRSYHRQLPILN---E-IRIN--RCV--M------------- --VP-Q-TE--RI-DLHC-FSDASEK-AYG-GCVYVR--SEDS-SG------NVLV-R-- LVAS---------------------------KSRV-APL-------S------------- ---C----------------------------QTIPRLELCGAL-LTA-ELFEKVNQA-- -I-R----L-P-----ADV---HF---------WT------------------------- ------------------------------VPGSVKRCYLPHHPV-------VKEA-STT TKV-RVVFNASSETS-TR---VTLNDALLVGPIIQ--DDLRSIIMRSR---TKQV--MLV ADVEKMFRQILVREE--DRPLQS-----I------LWRSS---P-EE---------EI-S TYELNTVTYGTKPAPFLATRV-LKQL------------S----DDE-EGRF--P-LAAKA V-RED--TYMDDV-ITGSN-D---VDEAVQLRVQLQ-EL-MNAG-------GFRLR-KWA SNYP-EA-LDGVGTEDLAI-PITE-I-SLD---------------------------P-- -DPAV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TI SRPFSRTGVDFFGPVY-------------------------------------------- ----------------------------VRPG--PRRT---A-V------KA-YGA---I -FICLA--TKAVHIELVSDLSTDRF-----IQALRRF-VARR-GKCADIFSDNGTNFVGA RNRLQ-E-------LLRLLKDK-GH------------------KEKVN---NFCLDEGMR ----WHFSPPSGPHFGGLWEAAVRSTKYHLQRVIG--D-----TPM----SIEDM----- --VTL-----LVQVEGCLNSRP--------ITP------------L-------------- ----------------------ST--------DPS--D-------L-------------- ----------- >181/1-561 ---NTKRTILSEIAKLYDPLGFLSPIIVLAKLLMQQ-LWRS-K----------V------ -GWDE-P-VED--EISQQWMQLKKSLEATN---Q-VHIP--RRV--L------------- --ID-D-AE--CY-ELHG-FADASMS-AYG-ACVFIR--SVFN-E-------SAQL-Q-- LLCS---------------------------KSKV-APL-------K------------- ---A----------------------------VTIPRLELCAAL-LLA-RLVNKVLQS-- -I-Q----M-P-F---HRV---VL---------WS------------------------- ------------------------------DPPNVQKCYLPHHAV-------IRPD-SSS TKC-RVVFDASAKPSQNS---LSLNDVLKVGGTVQ--SDILDIVLRFR---KHKY--AFT ADISKMYRQIMVAEM--HQPLQR-----I------FWRES---P-EQ---------PL-K VYQLTTVTYGTASAPFLATRC-LVQL------------A----EDG-KEKC--P-LGAST V-RED--FYVDDV-LSGDD-T---LSAAIERQQQVK-DL-LASA-------GFPIH-KWC SNSE-QL-LERIPEGDRETPK------VLE---------------------------EQG INTVI-----------------KV--LG-------------------------------- -----ILW---------------------------------------------------- ----------------------------------------------------------TP APPFSVTGVDYAGPFH-------------------------------------------- ----------------------------IK--QGLRKV---TTV------KG-YVA---V -FVCMV--TRAVHLELVSDMTTSAF-----IAALQRF-VSRR-GIVHQLHSDNGTNFRGA HHELN-Q-------LYQAFKQE-QD------------------THQIE---SFCVSKGIE ----WQFIPADAPEFGGIWEAAVKSMKSHLKRIVG--N-----ASL----NFEQY----- --VTV-----LTEIEAILNSRP--------LF-------------V-------------- ----------------------TS--------SRS--D-------S-------------- ----------- >182/1-549 ----TKRKVLSIIATLFDPLGFIGATTTAAKVFMQL-LWTL-E----------D-ENGKK LDWDQ-A-LPL--TVGESWRKLYIQLPILN---E-IRID--RCV--I------------- --VP-N-AV--SI-EIHC-FSDASKK-AYG-ACLYIR--SQGQ-AG------NVKV-Q-- LLSS---------------------------KSKV-API-------K------------- ---S----------------------------QSIPRLELCGAL-LAA-QLFDKVRQA-- -T-H----L-Q-----VRT---TF---------WV------------------------- ------------------------------DPEPTKRCFLPHHPV-------VKEA-STT TKV-RVVFDASCKTA-AG---LSLNDALLVGPVIQ--QDLRSIILRCC---TKQI--LLV ADVEKMFRQILVHHE--DRPYQS-----I------LWRPS---P-LE---------EV-G VYELNTVTYGTKPAPFLATRT-LNQL------------A----LDE-GDRY--P-LAVKA I-TED--TYMDDV-ITGCD-N---LEEAKNLQNQLD-GM-TRGG-------GFRLR-KWA SNCA-EV-LQGISEDNLAIRPVDG-I-NL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TV SRPFSKTGVDYFGPVY-------------------------------------------- ----------------------------IRPA--PRKT---A-V------KA-YGA---I -FVCMC--TKAVHLELVSDLSTERF-----LQALRRF-IARR-GRCTDLYSDNGTNFVGA RNQLQ-E-------LFRRWKDA-DH------------------QQDLA---RFCTNEGIN ----WHFNPPGSPHFGGLWEAAVRSAKHHILRVIG--T-----NSV----SHEDM----- --FTL-----FVQVEGCLNSRP--------LTP------------M-------------- ----------------------SE--------S--------------------------- ----------- >183/1-560 ---PTLRNMYKTLASQYDPLGFITPFTTRAKVIIQD-LWKH-N----------L------ -GWDD-PIEPS--HLRDTWLSWVEELPTLT---K-IHFP--RAY--T------------- -PAAADN-PSAIR-ELHV-FSDASER-AYG-SVAYLR--TTDE-QG------QIHI-T-- FVSA---------------------------RSRV-APR--K-C---------------- --------------------------------LSVPRLELCAAL-TGA-QLGKVIQTE-- -L------T-LPI---HKV---TF---------WS------------------------- -----------------------------------ESWFIPHHMV-------HHN----- GKD-RIVFNCSFQ-H-HG---QSLNDQLLPGPTLG--PSLLGVLLRFR---QHTV--AIS GDIKGMFHQVRLLPG--DKSVLR-----F------LW-RG---MCRE---------VEPE IYEWQVLPFGTTCSPCCAIHA-LQHH------------V----QEH-KEG---KTELVDI V-EHS--FYVDNC-LHSVP-T---ASEAKVIVDGLR-QL-LSEG-------GFEIR-QWA CNVP-SV-TEHL-------PSDARSASSERWL-----------------------AQSST -DLQE-----------------PT--LG-------------------------------- -----LRWDCINDTLGYN-----------------------------------------L ----------------------------------------------------------LY KPPFYSTGVDCFGPYA-------------------------------------------- ----------------------------VK--IG-R-----R-QE-----KR-WGI---I -YKCLT--TRCVHLDLLEHMDSDAF-----LLSLRRF-IARR-GKPMELLCDNGTNFIGG DRELR-E-------SFEAMSPK------------------------LQ---EQLAEQKIS ----FRHNPPNAPHFGGTWEREIKSVKTALQVILR--E---Q--SV----PEPVL----- --QTL-----LVEVENILNSKP--------LGY------------V-------------- ----------------------SS-------------DI--------------------- ----------- >184/1-546 ----TRRGILSTISSIYDPLGMLSPVILTAKKILRD-LCRR-E----------I------ -GWDD-T-VPE--SVSKDWLKWLQQLHLLD---V-FKVD--RCV--K------------- -PSCFGD--VVTA-QLHH-FSDASQD-GYG-TVSYLL--LKNQ-HS------VMHS-A-- FIMG---------------------------KARV-APL--K-S---------------- --------------------------------VTIPRMELIAAT-MAS-RMDILWRKE-- -M------H-MDL---LDS---VF---------WT------------------------- ---------------D---------------RSDGKVWYIPHHGV-------FHPT-K-- GKM-RVVFDCAAS-Y-QG---TSLNAQLLQGPDLT--SSLIGVMTRFR---KEPV--VIM ADVESMFYQVRVSSD--YSDLLR-----F------LWWPN---GDVE---------QQPV EYRMKVHLFGAASSPSCANYA-LRRC------------A----EDY-GCHY--SENAVDK L-LNS--FYVDDC-LVSVV-T---EKEAVSLYQELV-SL-CARG-------GFSLT-KWI TNRP-GV-LEAI-------PESHRARGMEGLN-----------------------ME--- ------------------------------------------------------------ -------L---------------------------------------------------- ----------------------------------------------------------PD EPPFTRVGVDYFGPFE-------------------------------------------- ----------------------------VK--SR-R-----S-MV-----KR-YGV---I -FTCLA--IRAVHLEVAPSLDTDSF-----INALRRF-ISRR-GQVREIRSDNGTNFVGA ERELK-A-------AIKQWNQG-Q----------------------IN---DLLLQKGIR ----WSFNPPAGSHHGGSWERLIRSVRKVLNSMFK--V---Q--NL----DEEGL----- --HTV-----LCEIEAIINSRP--------ITK------------A-------------- ----------------------SM-------------D--------PNDL---------- ----------- >185/1-566 ----TKRKVLSMIATLFDPLGLIGAVIVTAKIFMQR-LWCW-T----------D-GEGRK LDWDQ-P-LDT--NECEQWIELKQQIPSLN---E-ISIP--RCV--V------------- --AP-RGAT--AT-QIHF-FSDASKM-AYG-ACAYVR--SIDE-SG------RCCV-A-- LLTS---------------------------KSKV-APL--N-KKEK------------- ---T----------------------------QTIPRLELCGAL-LAA-QLKEKVFNA-- -L-K----I-D-----ARA---FF---------WT------------------------- -----------------------------------NRCYLPHHPV-------VKES-STT TKV-RVVFDASCKTS-SG---VSLNDVLLVGPVIQ--DDLRAIILRAR---TKQI--LIV ADVEKMFRQIWVDQK--DQVLQN-----I------LWRKD---F-NE---------RA-E TYELKTVTYGTKPAPYLATRT-LQQL------------A----EDE-KQRF--P-MAARA V-MED--VYMDDV-LTGED-N---TEEAKQLIIQLD-QM-MESG-------GFHLR-KWA SNSA-AV-LEGISSENLALTRDEG-V-QLD---------------------------P-- -DPAV-----------------KT--LG-------------------------------- -----LYW---------------------------------------------------- ----------------------------------------------------------TV ARPFSKTGVDYFGPVY-------------------------------------------- ----------------------------FRPG--PRRT---A-I------KA-YVA---L -FVCMC--TKAVHLELVTDLSTDRF-----LQAFRRF-IARR-GRCTDIYSDNGTNFVGA RNHLR-Q-------LLELLRSD-VH------------------KRDMI---KECAEEGIN ----WHFNPPSAPHFGGLWEAAVRSAKGHLLKVLG--D-----TVV----SFEDL----- --CTL-----LVQVEACLNSRP--------LTP------------L-------------- ----------------------SD--------DPS--D-------L-------------- ----------- >186/1-550 ---NTKRQLLSDSSKFFDPFGWIAPIVIRMKILFQH-LWLY-D----------L------ -SWDD-P-LPA--FILEEWIALKETLHHIE---R-IRIR--R-W--I------------- -PHSGSK--L----QLHG-FADASEA-AYA-AVVYVR--TVDQ-EG------RIET-N-- LVVA---------------------------KTRV-API--L-Q---------------- --------------------------------ISLPRLELMAAE-LLV-ELMVKVLES-- -F------S-HLE---VKI---FA---------WS------------------------- ------------------------------S------FYLPHHGV-------WKVD-SET TKL-RVVFDASSKSA-SG---VSLNDRLLVGPNVN--ESLFNVFTRWR---TYKI--AFC ADIEKMYRQVLVAKE--DADFQR-----I------VWRNH---P-EQ---------PL-E HYRLLTVTYGTASAAYQAVAT-LQQV------------A----ADN-KETH--P-MAAER I-PKN--FYVDDL-LSGAD-S---IEEAKFLRNDIV-QV-LNDG-------GFVLR-KWS SNDP-QI-LE-VDAVQDDPIHLKL-PQEDD------------------------------ ---SV-----------------KA--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------TP ARPFVHCGVDYAGPIL-------------------------------------------- ----------------------------LRSS--NLRT---AKTI-----KG-YVA---V -FVCLA--TKAVHLEAVSDLSTNAF-----LAALKRF-CGRR-GLCSEIWSDHGTNFVGA DRAIR-E-------HLQSPEFN-Q---------------------AVS---RYLSDLKIK ----WKFITPSAPHMGGIWEAAVKSFKKHLRAVLG--N-----TTL----TYEEL----- --STV-----LTQIEACLNSRP--------LCQ------------L-------------- ----------------------SS--------SVD--S---------------------- ----------- >187/1-545 ---PTKRQALSIVMSPFDPLGFLSFFLIHGKILIQK-MWRA-K----------I------ -KWDE-L-IPE--TLRKQWTDWMEHFKHLD---K-ISIS--RCY--F------------- -PSHSVK-DILSL-QLHV-FVDASED-AFA-CVAYLR--AEFA-NE-------IDV-A-- VVAA---------------------------KSKV-APL--K-A---------------- --------------------------------LSIPRLELMAAV-IGA-RLQSTIIEG-- -H------S-LHI---DQV---VL---------WS------------------------- -------------------------------------WYLPLGVV-------LNPK-K-P SKV-RIFCDAAAK-V-DG---ISLNTMLLKGPDLL--SSLFGVLCGFR---EKRV--ALC ADVKEMFHQIGIRKD--DRHAQR-----L------LWRDD---P-TQ---------A-PE IYLMDVSTFGATCSPCSAQFV-KNVN------------A----AEH-AKEY--P-LAAEA I-QRK--HYVDDY-LDSAD-S---EKEAIHIAEEVR-HV-HSLG-------GFHLR-NWL SNSK-AV-LARV--GE-SDSA----TEKSLQL-----------------------D-RGS ST--E-----------------RV--LG-------------------------------- -----LFW---------------------------------------------------- ----------------------------------------------------------AF ERPFSYVGVDYFGPIV-------------------------------------------- ----------------------------VR--VN-R-----S-NA-----KR-WIA---L -FTCLT--IRAVHLEIVHSLSTESC-----KMAFRRF-IARR-GAPVEVYSDRGTNFVGC SNELE-R-E------KKA-IDQ-Q----------------------LA---ETFTNANTK ----WIFNPPAAPHMGGSWERLVRSVKTALAA-MY--T---S-RIP----TEETL----- --ATL-----VAEAESIVNSRP--------LTF------------I-------------- ----------------------PL-------------ER--------------------- ----------- >188/1-556 ---PTKRQVASCVMSFFDPLGLLAPYLVFGKVLIQD-LWRE-G----------T------ -GWDE-P-ISD--ETFERWKQWMNVLDSIE---G-VRIP--RCY--F------------- -SSGD----LSSL-EIHT-FVDASET-AYG-CVSYFR--ITTA-YG------PAEV-A-- LVAS---------------------------KSKV-APL--K-P---------------- --------------------------------VTIPRLELMACV-LGV-RLAKYVVDG-- -H------T-LPV----RK---FF---------WS------------------------- ---------------S---------------GDPRRVCYLPLGAV-------TNPR-K-P GKV-RLIWDASAK-V-DG---VSLNSMLPKGPDQM--TLLPTVLFRFR---QYPVDFAVS ADIKEMFHQVRIRPE--DRHSQREKV--F------VYRTD---P-TS---------PVPE TYLMDVATFGSTCSPATAQFV-KNAN------------A----NQF-SHEC--P-RAVQG I-VHN--HYVDDY-LDSFA-T---IEEAAQVAAQVK-AI-HKYG-------GFEIR-NWC SNQR-AV-LEQL--GEV----EQQT-IIDLNS-----------------------G-LEK QX--E-----------------RV--LG-------------------------------- -----ILW---------------------------------------------------- ----------------------------------------------------------TY VRPFTYCGLDYFGPLL-------------------------------------------- ----------------------------VK--VN-R-----S-HV-----KR-WVA---I -FTCLT--IRAVHVEVVHSLTTESC-----IKGVRRF-ICRR-GSPAEIYSDNATCFQGA DRLLR-E-L-------LQ-INK-G----------------------LA---AEFTSTETE ----WKFIPPGTPHMGGAWERMVRSVKVALTSIQN--G---T-QKL----DDESL----- --MTF-----LAEAEAIVNCRP--------LTY------------L-------------- ----------------------PL-------------DS----------F---------- ----------- >189/1-532 ---PTKRIILSCIMSLFDPLGLLAPFTVHGKGLLQD-IWRS-G----------C------ -DWDE-L-VNE--DCYVKWTRLKAVFPFIN---R-IEIP--RCY--L------------- -RGAPPS-AYDTL-EAHV-FMDASQD-YYS-CAVYFR--ITHE-GA-------PKC-A-- LVSA---------------------------KTKV-GPL--K-P---------------- --------------------------------LSIPRMELLAAT-LGV-RLLDTVLAN-- -H------D-VKV---TKR---FL---------WT------------------------- -------------------------------------WYLPLSVV-------TNPK-K-P GKI-RLVFDAAAQ-V-NG---VSLNSMLLVGPDLL--APLDAVVQKFR---ERPI--AFG ADIREMYHQFLITPE--DKHVLR-----F------LFRTN---Q-QD---------K-PD IYLMDVAIFGSACSPASAQYI-KNLN------------A----SHY-SEHY--P-DASNA I-IRK--HYVDDY-MDCAN-T---TEEAIERAKQVR-YI-HSQA-------GLEIR-NWV SNST-QF-LEAM--GE-----PIKPERVSLSV-----------------------G-KEG ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF AKPFSYVGIDYFGPID-------------------------------------------- ----------------------------VS--VG-R-----R-ME-----KR-WIV---L -FTCLN--MRAIHLEVAYRLNAESC-----IMAIRRF-VVRR-GPPIAIFTDNGTNFKAA SKELQ-N-Q------IQR-IDA-E----------------------CA---NVFTNARTR ----WSFNPPSAPHMGGIWERMVRSVKEMMSA-LN--E---R-HRL----NDEIL----- --LTV-----IAEAEEIVNSRP--------LVY--------------------------- -------------------------------------QS--------------------- ----------- >19/1-566 ---ATKRNILSVTSKLFDPLGLLSPLVIKGKILLQE-LWLN-K----------L------ -DWDE-S-IPM--NLETAWNLLKESLGQLE---K-ITIP--RFV--H------------- --TD-P-MS--PI-QVHA-FADASMR-AYG-ACVYIR--RKTA-EG------FKV--S-- LLTA---------------------------KSKV-APL-------K------------- ---T----------------------------KTLPRLELCAAH-LLA-DLCHRIKSL-- -L-K----V-P-I---DKM---IF---------WS------------------------- ------------------------------TIPKTPHYFIPHQCV-------LRPQ-STS TKL-RVVFDASCKTS-SQ---VALNDILMVGPTIQ--DELYSTLLRFR---LHRY--ALT ADVKKMYRQVWVADA--DRQFQL-----I------VWRRD---P-SE---------SL-R IYQLNTVTYGTGPAPFLAIRC-LKRL------------S----ESA-KLSF--P-KAAEV I-DSD--FYVDDM-LTGAG-C---VEELKTIKSDVA-QV-LQTA-------GFELT-KWF SNSP-EV-TASESTVKPITIS--------------------------------------- DSEST-----------------KA--LG-------------------------------- -----ISWLPHED----------------------------------------------- ----------------------------------------------------------RA LRPFSVCGVDFCGPVY-------------------------------------------- ----------------------------TTLK--IRGR---PPY------KS-YIA---L -FVCFA--SKAVHLEIVSDLTTNSF-----LLAFQRF-VGRR-GCPQRVNCDNATNFVGA SRHFS-E-------LRRKIEAE-A--------------------DAIR---EFASRSGCE ----FAFIPPRAPHMGGLWEAGVKSAKGLLLRAVG--S-----ALL----TAEEL----- --ETV-----LVGIEAVLNSRP--------LGP------------L-------------- ----------------------SP--------DPS--D-------GDALTPGHL------ ----------- >191/1-542 ---PTKRSILSGISQLFDPLGLISPIIIKGKMLMQK-IWLL-P----------C------ -SWDD-P-VPE--DIAKSWEEYVLQIPKVA---N-FRVS--RYA--L------------- --LP-N-SS---V-QLHT-FTDASEL-AYG-ACTYAR--CVDP-SG------MVRI-Q-- LLAS---------------------------KSRV-APL-------K------------- ---K----------------------------ITLPRLELCAAD-IGA-KLHCRIVEA-- -L-Q----I-T-I---TSS---HF---------WS------------------------- -------------------------------------------------------A-STT TKV-RVVFDASAKTS-TG---FSLNEALLVGPVVQ--DDLLSIILRFR---TFPV--ALV GDIAKMYRQVLLHPD--DTPYQR-----I------LWRFD---T-ED---------SI-G SYELLTVTYGLSPSSFLATRT-LQQL------------A----DDE-GDSY--P-LGGPA L-RKS--FYVDDF-IGGAQ-S---IEEAIQLRQEMS-EL-LRKG-------GFELR-KWT SNQL-PV-LAGLQPDEIGTQS--S-I-KFD---------------------------E-- -NETV-----------------KA--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------TP SRPFAVTGMDFAGPVY-------------------------------------------- ----------------------------LKPV--HKRA---AAT------KA-YIC---I -FVCFC--TKAVHIELVSDLSTQAF-----LSALRRF-IARR-GRPTDLYSDNGKNFQGA ANELE-E-------VYRLLQDE-NL------------------RYQIT---TDRTSEQIA ----WHFTPPKAPHFGGLWEAAVKVAKSQLYRQLG--T-----SKL----SFEDM----- --ATV-----LAQIEASMNSRP--------IVP------------L-------------- ----------------------SE--------DPN--D-------I-------------- ----------- >192/1-544 ---ATKRNILSAIAQLFDPLGIIAPVVVQAKILMQH-LWLL-A----------L------ -DWDD-E-VSP--DLQRKWHQFCEQLPHLS---N-FSID--RFA--F------------- --VH-G-YC--SA-ELHC-FADASEV-GYG-ACMYIR--SEDH-EG------RVHV-S-- LLAS---------------------------KSKV-APL-------K------------- ---P----------------------------LSIPRLELCAAL-LAA-RLYEKVISA-- -L-D----M-K-F---SRS---FF---------WS------------------------- -----------------------------------KACYLPHHPV-------LKDS-SST TKV-RVVFDGSAKTS-SG---HSLNDSLLVGPVVQ--DDLFSLVIRFR---KFAI--ALV ADIEKMYRQIVMHEQ--DRPLQR-----I------LWRFD---S-TL---------PV-Q EFELSTVTYGLAPSSFLATRT-LLQL------------V----EDE-GTPF--P-HASTA I-KKN--TYIDDL-LAGAD-S---IDDAIQLREELS-NL-LQKG-------GFRLR-KWC SNSL-PV-LSGLPSELLGTQS--S-V-RFD---------------------------A-- -GE--------------------------------------------------------- -------I---------------------------------------------------- ------------------------------------------------------------ --AFACTGVDYCGPIF-------------------------------------------- ----------------------------LKPV--HRKA---AAR------KS-YIC---V -FVCLS--TKAVHLELVSDLSTAAF-----LMALDRF-VWRR-NKPQHLYSDNGTNFVGA KNELH-A-------LYTMLQSG-PD------------------NDKIA---KHLAEDNIQ ----WHMIPPRAPNFGGLWEAAVKVAKTHLVRQLG--S-----ALL----SFEEL----- --CTV-----LIKIEGCMNSRP--------LLP------------L-------------- ----------------------SS--------DPN--D-------L-------------- ----------- >193/1-563 ---WTKRNILSSIAKLFDPLGLISPIIVTAKMLMQE-LALL-N----------I------ -EWDT-P-VPV--DIEKKWKAFHSQMYKIS---E-LRIS--RFA--F------------- --AS-K-WV--SI-QFHC-FADASTL-AYG-ACLYVR--TTDA-VG------NVRI-E-- LLSS---------------------------KSRV-APL-------K------------- ---R----------------------------LTLPRLELCAAK-EAA-LLHSKVTKS-- -L-S----I-E-N---VQS---FF---------WS------------------------- ------------------------------AKSPRKGYYLPHHAV-------LKES-STT TKV-RVVFDGSASTD-SG---YSLNDALLKGPVIQ--DELLSLLLRFR---KHEV--ALV GDVEKMYRQVQVHSE--DTXLQR-----I------FFRFS---P-EE---------PV-K VFELTTVTYGLKPSSFLAIRA-LHQL------------A----TDE-GFEY--A-DATEA I-VHD--FYVDDY-IGGAS-S---VEKAIQLQNNLD-TL-MKKG-------GFALR-KWC SNRP-EV-LKGIPXDQLGTNL--S-I-SFX-------------------------XNP-- -XEKV-----------------KT--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------RP GRPFLITGVDYCGPFF-------------------------------------------- ----------------------------LKSP--RRNT---APS------KV-YIA---V -FVCFS--TKAMHLEMSSDLSTASF-----LSVLRRF-IGYR-GIPAEIHSDNAKNFSGA RNELK-A-------LYDLLHDP-LS------------------FSVIC---KELSQQGIK ----WHFIPPRAPNFGGLWEAAVRSVKTALKKEVG--L-----KQL----SYDQF----- --TTL-----LVQITATLNSRP--------LSP------------L-------------- ----------------------SD--------DPT--E-------F-------------- ----------- >195/1-563 ---PTKREVLSVVMSLYDPLGIVATFIVHGKVIVQD-TWRE-S----------I------ -GWDD-K-IPS--RIFQKWKQWLNLMAVIS---K-VRIS--RCY--F------------- -PGYDPI-SYNSL-QLHI-FVDASTE-AYA-AVAYFR--IVD--KG------EIRC-S-- LVSS---------------------------KTKV-APL--Q-A---------------- --------------------------------LSIPRLELMAAL-IGA-RLRKTIEEN-- -H------S-LKI---SRT---IL---------WS------------------------- ---------------S---------------FDPRRMWYLPLGVV-------TNPK-K-P GKV-RLVWDAAAQ-V-NG---TSLNDELLTGPDLL--TPLLAVMFQFR---EREV--AIS ADIMEMFLQILIRPE--DRSALL-----F------LWRDS---P-EQ---------P-IK VMVTNVAIFGATCSPVQSQFV-KNLN------------A----SEY-EENY--P-RASEA I-KNK--HYVDDY-LDSVD-T---VGEAVQLANDVT-TV-HGKA-------DFFIR-NWR SNRR-EV-LEGI--GE-----VNTVVTKQFTA-----------------------G-KEI NL--E-----------------RI--LG-------------------------------- -----MIW---------------------------------------------------- ----------------------------------------------------------PF VRAFTFVGIDYFGPYL-------------------------------------------- ----------------------------VK--VG-R-----S-VA-----KR-WGV---V -FTCLT--IRAIHIEVACSLSADSC-----KKAIRRF-IARR-GAPQEIYSDNGTNFIGV SRELA-K-E------LAE-INS-E----------------------LG---NSITDTYTK ----WRFNPPSAPHMGGCWERMVRSIKTALEV-IP--I---D-RKL----DDESL----- --ATM-----FLEAERMINSRP--------LTF------------V-------------- ----------------------SL-------------ATSDDEAITPNHF---------- ----------- >196/1-565 ---PTKRLVLSCMSSFFDPLGLLGPYVVKGKVIMQV-LWRE-G----------W------ -PWDD-E-LGD--KHYAKWSEYRSELNKLQ---N-LKVP--RRY--V------------- --QNIRPESLLNL-SLHV-FCDASET-AYG-CAIYVL--SYAI-FK------QLHS-S-- LVMA---------------------------KSRV-APL-------R------------- ---G----------------------------LSIPRMELCAAL-LGS-RLMENLRST-- -H-D----L-K-V---TPR---TF---------WT------------------------- ------------------------------RAPRSSQFFLPHHAI-------HRPE-SST TKI-RVVFDGSCRSA-SS---LSLNEVLFVGPTVQ--PALYSTVINIR---LPRY--VVT ADAEKMFRQIWVHPD--DRKYQQ-----I------LFRKD---P-SE---------PV-R IYQLKTVTYGLASSPYHATRV-LNQL------------A----IDE-GERY--P-LAVPV I-KKG--TYVDDV-LTGDD-D---EVKLAETCRQLI-EM-LHQA-------GFVLR-KWA TNNN-AV-LASVPSQLWETKP------ELE----------------------------ID RSPAI-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------SP ARPFIHSGMDYCGPFL-------------------------------------------- ----------------------------VRPL--SGRG---ASV------KV-YVA---L -FVCLV--VKAVHLEVVADLSSAAC-----INAVKRF-VARR-GRLLELHCDNATAFVGA DRELR-I-------MREEFRRQ-FR------------------SEDWN---NFCQESGIK ----FRFIPARSPHFGGIWEAGIKSFKHHFRRIMG--N-----RSF----DVDQL----- --QTV-----VAQIESVLNSRP--------LSP------------L-------------- ----------------------SD--------SPD--D-------C-------------- ----------- >198/1-545 ---PTKRQALRVVMSPFDPAGLLSFFLIHGKILIQD-LWRA-K----------T------ -DWDQ-P-IPE--KLRGKWLRWIELFNDME---Q-VRIP--RCY--F------------- -PYHSIN-DISSL-QLHV-YVDASEE-AYA-CVGYLR--AVFP-DG-------IRV-A-- LVGG---------------------------KSKV-APL--K-A---------------- --------------------------------QSIPRLELMAAV-IGV-RFSQTVLNG-- -H------S-LDI---QKV---FF---------WS------------------------- -------------------------------------WYLPLGVV-------INPK-K-P SKI-RIFCDAAAK-V-DG---ISLNSMLLKGPDLL--RTLLDVLFGFR---EKRI--ALC ADLKEMFHQIEIRKE--DRNAQR-----L------LWRED---P-TQ---------E-PE VYLMDVATFGATCSPCSAQFV-KNRN------------A----EEL-SSKF--P-AAADA I-IRK--HYVDDY-LDSAD-N---VEEAVKLAKEVK-HV-HSLG-------GFHLR-NWL SNSQ-AV-LTRV--GE-NDPA----AEKCLQL-----------------------D-KTS ST--E-----------------RV--LG-------------------------------- -----MYW---------------------------------------------------- ----------------------------------------------------------AY VRPFSYVGVDYFGPIA-------------------------------------------- ----------------------------VR--VH-R-----S-TV-----KR-WVA---L -FTCMT--TRAVHLEIVHTLSAESC-----KMAFRRF-IGRR-GAPVEIRSDRGTNFVGS SKDLK-L-E------MNK-IDR-Q----------------------LA---ETFTNANTK ----WLFNPPGAPHMGGVWERLVRSVKTALAA-MH--T---S-RIP----NEETL----- --ATV-----LVEAESVVNSRP--------LTY------------I-------------- ----------------------PL-------------ET--------------------- ----------- >2/1-535 ---ATKRNILSVTSKLFDPLGLLSPILIKGKILLQE-LWLN-K----------L------ -DWDE-S-IPL--HLETAWNKIQLALSQLE---E-ISIP--RFV--M------------- --SE-P-MS--PI-EIHA-FSDASMR-AYG-ACVYIR--CKSA-EG------SKV--S-- LLTA---------------------------KSKV-APL-------K------------- ---T----------------------------KTLPRLELCAAH-LLA-DLCRKIKPL-- -I-K----A-P-I---ERS---VY---------WS------------------------- -------------------------------------------------------Q-STT TKL-RVVFDASCKTS-TQ---KCLNELLMVGPTIQ--EELYSTLLRFR---LNKF--ALV ADIKKMYRQVMVNEA--DRRYQL-----I------VWRKD---P-SE---------SL-K LCKLNTVTYGTAPAPFLAIRC-LKRL------------S----ESA-KNTF--P-RAAKV I-GSD--FYVDDM-LTGAG-C---VEELKTIKSEVT-QV-LQNA-------GFELS-KWF SNSP-EV-TASESTVKPITLS--------------------------------------- DSELT-----------------KT--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------RA LRPFSICGVDFCGPIE-------------------------------------------- ----------------------------TTLK--IRGR---PPY------KS-YIA---L -FVCFS--SKAVHLEVVSDLSTDSF-----LLAFQRF-VGRR-GCPQTVHCDNATNFVGA SRHFA-A-------LRHQIESE-A--------------------DELR---QYASKKGCV ----FAFIPPRAPHMGGLWEAGVKSAKHLLLRAVG--S-----AKL----TAEEL----- --QTV-----LVGVEAVLNSRP--------LGA------------L-------------- ----------------------SQ--------DPS--D-------G-------------- ----------- >20/1-531 -----KREMLAYLMKIYDPLGLAANYTTQAKVIIQE-IWKT-E----------L------ -DWDS-P-VPE--RIMEQWQRWKERIKELE---H-IQIP--RCY--S------------- -VAS-NI---EVT-ELHT-FVDASEK-AFA-AVVYLR--TLTE-KG-------IDV-N-- IVAA---------------------------KTRV-API--K-P---------------- --------------------------------LSIPKLELQAAV-LGV-RLAETVKEE-- -L------R-ITT---DRD---YY---------WS------------------------- -------------------------------------NYIPHFMV-------INPN-KPT PKP-RLVFDAAAK-N-EG---ISLNSTLLSGPDAT--TSIFGVLIRFR---EYPI--ACS GDIKEMFHQIRIRKE--DQVAQR-----F------LFRD----N-PR---------NEPQ VYVMNVMTFGATCSPACAQFV-KNEN------------A----LKY-KDKY--P-TAVEA I-VKN--HYVDDY-LDSFR-T---INDAIKTINEVC-LI-HDRA-------HFFMR-NFV SNCQ-EV-IRSI--------PDDRSSQQEL-L-----------------------HISNK DMNFE-----------------KI--LG-------------------------------- -----QYW---------------------------------------------------- ----------------------------------------------------------VF KKPFTHTGVDYFGPMT-------------------------------------------- ----------------------------VS--IG-R-----R-VE-----KR-WGA---I -FTCMT--TRAIHLEIAKDLSTNSF-----IMCLKNV-QHRR-GKICHIYSDNGTNFVGA NRQIT-E-------LIERC-----------------------------------ATNGIK ----WHFNPPAAPHFGGVWERMVREVKSLLP-N----N---D-NMP-----EEVL----- --RSA-----FIEIEFILNNRP--------LTH------------I-------------- ----------------------PL-------------ET--------------------- ----------- >200/1-517 ---PTKRQLLRIVMSIYDPLGLVSTFVVHGKIMIQE-VWRS-K----------T------ -GWDE-R-IPT--SILVRWQQWLICLQGME---E-IEVP--RCY--F------------- -SGYERC-SFDTL-QLHI-FVDASAE-AYA-AAAYFR--IVD--RG------VVRC-A-- LVSS---------------------------KTKV-VPL--Q-P---------------- --------------------------------LSTPRAELLAAV-LGA-RLRKTIEEG-- -H------S-LKV---HRT---YF---------WC------------------------- -------------------------------------WFLPLGVV-------LNPK-K-P NKV-RLVWDAAAT-V-DG---VSLNTMLMKGPDLL--TPLLHVLFTYR---EREV--AIT ADVKEMFHQLLVHEE--DRSALL-----Y------LWRNS---T-ES---------A-LD TMVMDVAIFGASCSPTQAQFV-KNLN------------A----KEY-EHQY--P-RAAIA I-TRR--HYVDDY-LDSVD-S---VDEAVELITQVM-EV-HDKA-------GFHIR-NWI SNKE-DV-MRA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFSYVGIDYFGPYL-------------------------------------------- ----------------------------VK--IG-R-----S-SV-----KR-WVA---L -FTCLT--IRAIHLEVAATLSTDSC-----KKAIRRF-IARR-GAPLEIFTDNGTNFVGA GKELA-N-E------IMK-LNV-E----------------------LS---STFTDAHTQ ----WRFNPPAAPHMGGCWERMVRSVKVALGS-VP--T---L-RKL----DEESL----- --STM-----LAEAEYMVNSRP--------LTF------------V-------------- ----------------------PL-------------AT--------------------- ----------- >201/1-539 ---PTKREILKVVMSLFDPLGLISFFLIHGKVLIQG-IWAS-G----------A------ -GWDD-K-INE--NLFQQWRQWINCFDQLE---K-LRIP--RCY--F------------- -STPYSS-SESRL-EAHV-FVDASET-AYC-CVVYFR--MVN--AN------GIQV-A-- LIGS---------------------------KSKV-APL--K-T---------------- --------------------------------LSIPRLELKAAV-LGT-QCLQSVQSN-- -H------E-IPV---LQR---YL---------WT------------------------- ---------------S---------------VDRNRLWFLPLGVV-------QHPR-K-- QKV-RLIWDAKAT-V-GS---ISLNSKLLKGPDLL--TPLVAVLSSFR---QFPV--AVC GDIREMFHQIKIREQ--DRLSQC-----F------LWRDR---P-SD---------D-IQ IFVMDVATFGSTCSPVSAQFV-KNLN------------A----EEL-SDQY--P-RAAIA I-TKH--HYVDDY-LDSFK-T---IQEAVEVVKEVK-YV-HSRG-------GFELR-NFL SNSG-EV-LQAI--GEE----SADT-TKNLAL-----------------------E-R-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF VRPFTYVGVDYFGPVL-------------------------------------------- ----------------------------VR--LG-R-----S-QV-----KR-WVA---V -FTCLT--IRAVHIELVHSLSTESC-----IMAVRRF-VARR-GPPAEIYSDNGTCFQGA SRDLE---E------QRN-MNE-A----------------------LA---STFTSAQTK ----WLFIPPAAPHMGGAWERLVRSVKVAIGAVAE--A---P-RKP----DDETL----- --ETI-----LVEAEFMINSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >202/1-499 ----TKRTILQFIASQYDPLGLLVPIMIKLKLFIQH-LWK-EN----------I------ -PWDQ-S-LNK--QDEQQWINLIKEWPT-N---I-IELP--RFV--M------------- ----E---TSRLT-EFHIRFTDASKV-AYSCAAIYIL--NHGYQN--------TYS-XFI LILC---------------------------KSRI-API--K-------G---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HYLPHHEV-------LTP-SKST TKL-RIVYDASAHHK-GF---KSLNEVLYRGPVML--PDLVGVILRFR---MMKI--VIT ADIEKAFLQLELQNE--ERNCTR-----F------LWLDD---I-DK----ELTNENI-K RYRFKRVPFGIISSPFLLAAT-LNYH------------L------ENHGS---E-LA-WE I-RKN--LYVDNV-IISAN-G---TEEALYKYERTE-EI-FGEA-------SMNIR-EFL SNDE-KF-NERIPECDL--S---------------------------------------- QTNRE-----------------IF--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------KR SRTFEQVGLDYMGPLS-------------------------------------------- ----------------------------VKS--NTGLV------------KR-WIA---L -FTCFT--TRAVHLEMAENLSAENF-----SHVLRRF-IARR-GYPKLILSDNASQFQLV FKTIM-E--------------E------NA-----------------N----FLATKGMI ----WKNTIPRAPWGGGVYERLIGLTKRALRRAIG--R-----KLL----KEGEL----- --ITL-----IVEIEGILNTRP--------LTY------------V-------------- ----------------------GF--------G-L--T-------TTES----------- ----------- >203/1-532 ---PTKTQLLSIVMSIYDPNGLVAVFVIHGKILVQD-VWRS-G----------V------ -GWKD-K-IPE--KLIGRWKQWIALLRKIE---T-VRVP--RCY--F------------- -KDYEPA-SLKTL-QLHV-FVDASEQ-AYS-AMAYFR--LED--RG------QVRC-S-- LVAT---------------------------KTKV-APL--Q-P---------------- --------------------------------LPIPRLEVQSGV-TGS-RLRKTIEDG-- -H------S-LPI---SKV---VF---------WS------------------------- -------------------------------------WYLPLGVV-------LNPK-K-P GKV-RVIWDAAAK-V-DG---VSLNTMLLKGPDLL--TPLLSVLFQFR---ERQV--AIC ADIEAMFHQVKIREP--DRSAQL-----F------LWRDS---P-DK---------P-LE TMVTDVAIFGATCSPAHSQYV-KNLN------------A----DEH-EADH--P-KAAAA I-RNK--HYVDDY-LDSVD-T---ADEAVAMALEVA-EV-HAKA-------GFHIR-NWI SNDK-TV-LARI--GA-----VNPTTVKNFVI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFTFTGVDYFGPVL-------------------------------------------- ----------------------------IK--VG-R-----S-AA-----KR-WVA---L -FTCLT--IRAVHLELVASLSTDSC-----KKAIRRF-IARR-GAPQEIYSDNGTNFQGA SGELS-K-E------LAKVNHN-E----------------------LS---STFTDTHTQ ----WRFNPPAAPHMGGCWERMVRSVKAALGA-IP--V---E-RKL----DEESL----- --VTL-----LAEAEHMVNSRP--------LTF------------V-------------- ----------------------PL-------------ES--------------------- ----------- >204/1-562 ----TKRTVHSDSAMLFDPDGFLAPVVVQAKIICQQ-LWRI-K----------S------ -DWDV-P-LDE--SLQQLWRDYRMSLMAVA---T-IKVP--RWI--G------------- --FSID-CV--EI-QIHG-FCDASER-AYG-AGLYLR--CTAL-NG------SVTC-R-- LFLA---------------------------KSKV-APM--E-NLKR------------- ---KKKK-------------------------VNIPRLELSSGL-LLS-HMYEKVQSI-- -L-P--------A---AQL---FC---------WT------------------------- -----------------------------------PVYYLPHHAV-------LKPD-STT TKL-RVVFDGSCGTS-SG---VSLNDALMVGPVVQ--SDLLSTVLRFR---LHRV--ALI ADVEKMYRQIRVTLS--DQRLQR-----I------YWRDN---E-DE---------PV-K TYELSTVTYGTSSAPYLATRC-LKKL------------G----EDC-AESH--P-VASRV I-QED--FYVDDM-LSGAD-S---IEEASALMKEVR-QV-TDSA-------GFTLR-KWN SNCP-EL-LKRLPKHLKDERS--T-L-EID---------------------------P-- AKTTV-----------------KT--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------NP APPFLHVGVDYCGPFL-------------------------------------------- ----------------------------VSYP--NRRA---KPV------KC-YVA---V -FVCLA--VKAVHLELVSDLTSQAF-----IAALRRF-VARR-GKPLQIKCDNATTFVGA KNDLM-E-------LHRLFYKQ-QF------------------QDVVT---KTALEDGIE ----FSFIPPRSPNFGGLWESQVKSFKTHLKKTFG--L-----QVL----KMDEM----- --LTA-----LAQIEAVLNSRP--------LTP------------I-------------- ----------------------SN--------DPQ--D-------F-------------- ----------- >205/1-542 ---PTKRIVLSCVMGFFDPLGLLSPFTIHGKIIIQH-LWRT-G----------C------ -RWDQ-D-IDD--EAWILWKRWTALLPEVE---A-LRFP--RSY--F------------- -GDAMST-SVESL-ELHI-FSDASEL-AYG-CAAYLR--AVID-GQ-------VHC-S-- LVMA---------------------------RSKV-APL--K-R---------------- --------------------------------QSIPRLELMAAC-MGA-RMSQQILGT-- -H------T-LQI---DRT---VF---------WT------------------------- -------------------------------------FYLPLNVV-------VNPK-K-P GKV-RLVWDAAAT-V-DG---VSLNSMLVKGPDLL--VPLVSVICGFR---ERRV--AFG GDIREMYHQLKIISG--DKQAQR-----F------LFRDN---I-NE---------E-PK VYVMDVATFGSKSSPASAQYV-KNRN------------A----EEH-AGQY--P-DAVAA I-INR--HYVDDY-FDSVD-T---VEEAVKRAKQVS-HV-HKQG-------GFEIR-NWV SNSP-EV-LTAL--GE-----EKPMSPVLLNQ-----------------------D-KQT PS--E-----------------RV--LG-------------------------------- -----VRW---------------------------------------------------- ----------------------------------------------------------AT MRPFSAVGVDYLGPVE-------------------------------------------- ----------------------------VT--VG-R-----R-RE-----KR-WIA---V -FTCLA--VRAVHLEVVHSLTTQSC-----LMALRRF-ACKR-GVPEKVFSDNATCFRGA DAAMT-K----------E-INK-E----------------------CA---EQMTSPTTS ----WSFIPPGTPHMGGAWERMVRSVKEALRA-LD--D---G-RKL----TDEIL----- --STS-----LAEAEDMINTRP--------LTY------------V-------------- ----------------------PQ-------------DS--------------------- ----------- >206/1-584 -----KRLMLSAINGIYDPLGIVSPVVISAKLLFKQ-AIQL-K----------L------ -TWDQ-E-LPQ--DLMSQWKNWTCQAQGIE---N-IQLS--RQY--I------------- -ASSSSP--SEIM-ELHI-FCDASTK-AIA-AVTYAR--QRSI-S-------TCSS-G-- FVMS---------------------------KAKI-APM----D---------------- --------------------------------TTVPRLELCAAV-LAT-QLSQIIKRE-- -T------G-QLF---QKI---FF---------HT------------------------- -------------------------------------WFLPYHKV-------THPQ-K-P DKV-RIVFDASAE-C-QG---KALNHVLLKGPDLL--NSLLGVLLRFR---EKKY--AVI ADIHKMFYAFLVCPE--HRRFLK-----F------LWFRD---PESL---------SDVT EYQMRVHVFGNTPSPAVANYC-LKRT------------A----DKF-GHLF--SQSASVI V-NQN--FYVDDL-LVSYD-S---AQQASKSVKEIQ-EM-LGKA-------NIRLH-KIN SNSP-EI-LQAF-------PPKDLVE--KDAS-----------------------KLFQD -LNAQ-----------------AS--LG-------------------------------- -----LLWNVATDCFTLRAPKLAKVTSKRL------------------------------ ----------------------------------------------------------AT DPPFSHIGIDVFGPWE-------------------------------------------- ----------------------------VT--VR-KTRGGSA-NS-----KR-WAV---L -FTCLV--IRAVHIEVIEGMDSSSF-----LNALKRF-IAIR-GPVKTIRSDHGTNFIGA TKELD-C-------LTLFEKDE-A----------------------IR---EFSNQEQIV ----WMFNVPHASHMGGAWERMIGICRRILSSILT--EH--K--YL----THEML----- --VTF-----MAEISAIINNRP--------L--------------A-------------- ----------------------PL-------------TSDPDNPQLLTPALI-------- ----------- >207/1-560 ---ATKRNVLSVLAGMFDPLGIVSPVTVAARILFQT-LCRMTE----------L------ -TWDE-E-LTG--EVRKEWEAWVKDLGNLM---S-VEVP--RCV--L------------- --DTSNRKV-----QIHG-FADASRK-AYC-AVVYL---VYDV-GG------ERQV-R-- LLCS---------------------------KTRV-APL--K-E---------------- --------------------------------MTIPRLELMAAL-ILA-RLVSHVKEA-- -LGT----L-IEV---ERE---VY---------WS------------------------- ------------------------------KIH-----YLPHRAV-------VRRNVATS TPV-RVIYDASAKTG-KR--GVSLNDCLHVGPSLN--PLLFNVLLRFR---LHRV--ALI ADIEKAFLNIEVDPG--DRDCLR-----F------LFPED---P-RRED------SVI-K VYRFCRVVFGLNASPFLLNGT-LRHH------------L----VKFKEIDP--E-FV-EM L-VNS--FYVDDL-VTGSN-T---PEEAYELYVKSK-SR-LAEG-------GFNLR-KWQ TNDS-EL-RGRVDVSEGRCMP--------------------------------------- GSQEGVARGKTSQGVASDCDIQKV--LG-------------------------------- -----LPW---------------------------------------------------- ----------------------------------------------------------TQ AEPFSKVGVDFAGPLY-------------------------------------------- ----------------------------YKS--S--TG---MMQ------NA-YVA---L -FSCCV--TRALHLDLVVDLEACTF-----RRCLRRF-AARK-GAPTLIVSDNAKTFKAA AKALR-E-------LYDH--------------------------PEVQ---AYLEVNRVS ----WQFNLEKAPWWGGFYERMVGSVKRCLRKTLG--E-----ARL----TYDEL----- --ITV-----LVEVEXTLNDRP--------LTY--------------------------- ---------------------------------V-------------------Y------ ----------- >208/1-572 ----TKSKILSVIAQLYDPLGLIAPVIVRAKILMQL-LWTI-S----------I------ -DWNE-E-VPV--EIRTIWESYVKDLTLLS---D-FRIS--RLA--F------------- -----D-VG--EV-QFHC-FADASES-AYG-TCVYAR--TLKP-NG------EVKV-V-- LLAS---------------------------KSRV-APL-------K------------- ---K----------------------------RSIPRLELCAAQ-LGA-QLSSRVVAA-- -L-K----M-K-T---TPV---FY---------WT------------------------- ------------------------------EPEPHTVCYIPHHAV-------QKES-SST TKV-RSVFDASAKTS-SG---FSLNEALLVGPVIQ--DELLDIVIRLR---RHKV--VLL ADIEKMYRQVEIHPD--DRPLQR-----V------LWRFN---K-SD---------PI-T KYEMTRVTYGLAPSSFLATRT-LLQL------------A----EDE-GDSF--P-LAASA L-KQD--FYMDDF-IRSVA-T---ISQAIQLRKEMD-EL-LRRG-------GFPLR-KWC SNFS-EV-LEGVPSENLANPS--S-Q-TFA---------------------------P-- -DEAI-----------------KA--LG-------------------------------- -----ISWEPASDQFRFNVGPF-------------------------------------- ----------------------------------------------------------TP SRPFASTGIDYCGPVF-------------------------------------------- ----------------------------VKPA--YRKS---APT------KA-YIA---L -FVCFS--TKAVHIELVGDLSTASF-----LSALQRF-IARR-GKPEHVYSDNATNFVGA KNELH-A-------LYRMLSST-DE------------------INRIS---SALATDGIQ ----WHMIPPRAPNFGGLWEAGVKVAKKHLLRQLG--S-----SPL----LYEDL----- --VTI-----LVIIEGAMNSRP--------LAP------------L-------------- ----------------------SE--------DPN--D-------F-------------- ----------- >209/1-563 ----TKRVVVSDVSRLFDPLGLVGPVVIQAKIFIQE-LWKQ-G----------C------ -GWDE-P-LDS--KLQDKWQEYRRNLQGLE---S-LTVP--RWV--G------------- --TGTQ-IV--ST-EIHG-FCDASNK-AYG-ACIYIR--TISE-TG------EVNV-R-- LLTA---------------------------KSRV-APL--D-SLKK------------- ---GNKR-------------------------LSTPRLELSSAL-LLA-HLFEKVTNS-- -L-E----I---E---ANC---FF---------WT------------------------- ------------------------------SR-----YYLPHHAV-------LKPD-STT TKL-RVVFDASCQTS-TG---VSLNDALMVGPVIQ--DDLTSISLRFR---THRI--AIN ADIAKMYRMIRVQGQ--DYPLQS-----I------KWRYE---P-SE---------PI-R TYELTTVTYGTSSAPYLATRC-LQRL------------A----EDG-EATH--P-VASKV I-RKD--FYVDDM-LSGVD-T---VEEGRRLVRDVI-EL-SKSA-------GFTLR-KWN SNSK-EL-LEVIPXELRDVRS--V-L-EID---------------------------S-- SDTAV-----------------KT--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------TP CSPFQRVGVDYCGPFN-------------------------------------------- ----------------------------VAYP--HRRN---RPV------KI-FVA---V -YVCLV--TKAIHLELASDLSAQGF-----IATLKRF-ASRR-GKPEIIMCDNGRNFVGA RRQLE-E-------LRHLFNNQ-QF------------------QQSVI---RNSAEDQIQ ----FRFIPARSPNFGGLWESAVKSFKLLFKRTVG--S-----HTL----LYDEM----- --QTI-----LTQVEAVLNSRP--------LTP------------L-------------- ----------------------SN--------DPD--D-------Y-------------- ----------- >21/1-549 ---PTKRRVLSVIMSIFDPLGLLGFFNIRAKIILQN-IWRS-N----------I------ -GWDD-D-LTN--EDEADWQHWLDLVSNLN---A-VRIP--RCM--K------------- -WVSRTQ----AV-QMHT-FVDASMN-AYA-AVVFLR--AEL--DG------QVHC-S-- LVAS---------------------------KTRV-APL--K-P---------------- --------------------------------VSIPRMELMAAV-LGL-RLAKCIQKE-- -M------S-VRI---HRR---TF---------WT------------------------- -----------------------------------TSWFLPIFTV-------TNPN-K-- KKT-RLVWDAAAK-V-SG---MSLNDCLLKGPDTL--ASLMGVLIRFR---ERPI--AVS GDIREMFHQVKVRLE--DQPAQK-----F------LWRDG---D-SS---------RFPE TYVMQVMTFGASCSPALANYV-KNRN------------A----ERF-VAEH--P-DAVKA I-CEN--TFVDDW-LQSVD-T---GAEMIQLAETVK-RI-HASG-------GFEMR-RWT SNSK-QV-IQAL--ED---DCEE--LDKRISA-----------------------QDE-A -Q--E-----------------KV--LG-------------------------------- -----LWW----QDLLTFV----------------------------------------- ----------------------------------------------------------PY TPPFTYTGVDYFRPYD-------------------------------------------- ----------------------------IV--VG-R-----R-RE-----KR-WGV---L -FTCLT--VRAVHLDIATSLSTDSY-----LCVLKSF-VARR-GCPRRMLSDNGTNFRGA SRVLK-D-------EIERISPA-L----------------------IE---RQY--PELE ----FTFIPPGSPHMGGSWERMVRSTKSILSEILP------P-SGL----REEVL----- --RAA-----LADVESVLNSRP--------LTY------------V-------------- ----------------------PL-------------ET--------------------- ----------- >210/1-561 ----TKQSVLSDIARLFDPLGLAGPILVQAKLFLQD-LWRD-G----------C------ -EWKE-P-LTE--SRQHQWLELRDSFRQLA---D-LSIP--RWV--V------------- --ATTN-VV--SL-ELHG-FSDASER-AYG-ACVYIR--AVSN-TG------SIHV-N-- LLTA---------------------------KSKI-APK--G-KGLK------------- ---GGV--------------------------VSLPRLELCGAL-LLS-HLFEKVESS-- -L-N----L---K---AKN---FF---------WT------------------------- -----------------------------------PAYYLPHHCI-------VRPD-SLT TKL-RVVFDASCTTD-SG---ISLNDALRVGPVIQ--DDLLTIVLRFR---MPQF--AII ADIEKMYRQIRVRDS--DQPLQR-----I------RWRDS---P-TQ---------PL-Q TFQLTTVTYGTSSAPYLATKC-LQKL------------S----EEG-AESH--P-AAAIV L-GRD--FYMDDM-LTGTD-S---IDEGRNLCQELI-EL-TNSA-------GLPLR-KWA SNSS-AI-LEAVPSHLRDERT--L-F-ELD---------------------------S-- SASPI-----------------KA--LG-------------------------------- -----LQW---------------------------------------------------- ----------------------------------------------------------QP AFPFLHTGVDYCGPFM-------------------------------------------- ----------------------------CRPT---RRA---TAV------KC-YVS---V -FVCLV--TKAVHLECVADLTTNSF-----LAALKRF-VARR-GKPKLIQCDNALNFQGA KRELE-E-------LARLFRSQ-QH------------------RDQVT---RSCLEDGIT ----FKFIPPRSPNFGGLWEAAVKSMKNHLRRTVG--N-----VIL----YQDEF----- --WTL-----LTQIESCLNSRP--------LTQ------------L-------------- ----------------------SS--------DPN--D-------L-------------- ----------- >211/1-543 ---PSKREMLRVVMSIYDPLGLVATFVIHGKILIQD-VWRA-R----------I------ -DWDQ-K-VPL--DVFNRWKLWLAVLLTMS---S-VRIP--RCY--F------------- -PGYEPD-SYRSL-QLHI-FVDASEQ-AFA-ACAYFR--IVD--RG------SVRC-C-- LVAS---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELMAAV-IGA-RLKKTIMEN-- -H------S-LEI---RQT---FI---------HS------------------------- -------------------------------------WFLPLGVV-------LNPK-K-P GKV-RLIWDAAAK-V-KG---VSLNTELLSGPDLL--APLLRVMFGFR---ERQV--AIC ADIMEMFHQILIREE--DRSAQL-----Y------KWRDS---P-DL---------T-ME TMIMDVAIFGATCSPTQSQYV-KNKN------------A----DEY-EVTH--P-RAANA I-KKK--HYVDDY-LDSLD-T---VQEATELALEVA-KV-HAXG-------GFFIR-NWI SNDK-TV-LKQI--GE-----NSPTTVKSFIG-----------------------E-GQA ----E-----------------RL--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PF KRPFTYTGVDYFGPYF-------------------------------------------- ----------------------------IK--VG-R-----S-AV-----KR-WVA---L -FTCLV--TRAIHLEVVSSLSTDSC-----KKAIRRF-IARR-GAPVEFYSDRGTNFVGA SRELI-E-E------IKR-INV-Q----------------------LS---STFTDHQTQ ----WKFNPPAAPHMGGCWERMVRSVKIAMGV-LP--F---E-RKL----DEESL----- --ATF-----LAEAEHMINSRP--------LTF------------V-------------- ----------------------PI-------------ES--------------------- ----------- >212/1-562 ----THRVVLSEVAKLFDPYGLVGPVIVLGKLFLQE-LWKA-K----------Y------ -SWDE-L-LNE--DLQSRWLEFRSNLSELV---S-ISVP--RWI--A------------- --FGRD-VI--SC-EIHG-FSDASEK-AYG-ATIYLR--CVSM-NG------EITV-N-- LVMA---------------------------KSKV-APL--E-DLSR------------- ---RKKK-------------------------QCIPRLELSAAL-LLA-HLYETVSSS-- -L-K----I---A---STA---FF---------WT------------------------- -----------------------------------PDYYIPHHAV-------MKPD-STT TKL-RVVFDASCPTD-SG---VSLNDVLMVGPVVQ--DDLRSILLRFR---LFKY--AVV GDAEKMYRMVWQHVS--DQQLHK-----I------FWRDT---V-EE---------PL-R TYRLKTVTYGTSSAPYLATRC-LNKC------------A----EDG-VERY--P-AAAAV V-KKS--FYVDDM-LAGTH-T---IEEGKLLCKDVL-DL-LKGS-------GFNLR-KWN SNHP-EV-LQEIPSHLRDDRA--V-L-DLD---------------------------E-- -KATV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------AP APAFQRVGVDYCGPFE-------------------------------------------- ----------------------------LQPA--TRRA---APL------KC-YLS---I -FVCLV--CKAAHVEIVMDLTSEAF-----LAALRRF-VARR-GRPELILCDNASNFVGA RRELY-E-------LHRMFQQQ-QF------------------QERVS---TEAARDLIE ----FKFIPARSPNFGGLWEAAVKSLKGHMKRVIG--N-----RLL----KIDEM----- --NTV-----VTQIEACLNSRP--------LTP------------L-------------- ----------------------SN--------DPR--D-------L-------------- ----------- >213/1-546 ---TTKRKILSEVAKIYDLLGLVGPVITAAKLILRE-VSVL-Q----------V------ -DWDD-P-VPQ--SIIHKWRCFREELTCLN---N-LRVP--RWI--S------------- --TGDTVSV-----QLHG-FSDASDE-AYG-ACIYTR--VVQN-DG------SVTI-R-- LVCS---------------------------KSRI-LPK--K--MNK------------- ---CKP--------------------------ITTPRAELLGAV-LLS-RLLEKTIAA-- -ID-------IDF---ESV---IL---------WT------------------------- -----------------------------------SAYYIPHHCV-------VKPS-STS TKL-RVVFDGSATSS-SG---VAINDALMSGPNIQ--NDLFSILLNYR---GYRY--VFT VDVIKMFRQVGVLPP--DTAFQR-----I------VWRYD---R-NE---------PL-M VYELLTVTYGLASSAFQATMA-LRQV------------S----EDH-QHEY--P-QAARV I-KKS--TYMDDV-IGGAH-R---IQDACALQKEVS-EL-LQKG-------CFGTH-KWC ANRP-EI-LQHVEKEFHGTDF--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QP APTFAFTGVDFAGPFM-------------------------------------------- ----------------------------IKSSTAGRRP---LVT------KA-YVS---L -FVCML--TRAIHVELVSDLTTNAF-----LAALRRF-TSRR-GLPCKMFSDNATNFVGA QNELE-E-------LARLFEDQ-QQ------------------AKKIT---DFCTTQGIE ----WTFIPPRSPHFGGIWEAGVKQVKHHLTRIVG--G-----YKL----SYEEL----- --YTT-----LTQIEAVLNSRP--------LVP------------S-------------- ----------------------SD--------DPC--D-------F-------------- ----------- >214/1-565 ----TKRIALSDAAKLFDPLGLVGPVIVQAKIYLQD-VWRS-Q----------I------ -GWDE-P-LAE--ELQQRWHEFRENLLALR---N-LSVP--RWA--V------------- --PAVE-PT--SI-QMHG-FCDASMK-AYG-ACLYIR--VVAD-DG------TISV-N-- LLTA---------------------------KSKV-APL--A-DSRK------------- ---QKR--------------------------VCLPRLELSAAL-LLA-HLFQKAQAA-- -I-S----L---E---AQS---FF---------WS------------------------- ---------------------------------------LPHHCV-------VRPD-SLT TKL-RVVFDASCATS-TG---VSLNDGLMVGPVVQ--DDLVSITLRFR---MSRY--AIV SDIEKMYRQILLYYP--DRRFQK-----I------LWRNS---P-SE---------PI-R TFQLSTVTYGTSCAPYLATRC-LLEL------------A----KIG-ETTH--P-QAARV I-PKD--FYMDDL-LTGIN-K---IAEGQQLCSQML-DL-LQSA-------GLCLR-KWS SNCP-AL-LEHLPSDLRDERT--V-F-DLD---------------------------S-- -SASI-----------------KT--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------SP TLPFLYTGVDLCGPVY-------------------------------------------- ----------------------------YRIP--GRKS---KPV------KA-YIA---L -FVCLS--IKAVHIELVADLSTSSF-----LAALRRF-VARR-GKPKLIECDNALNFRGA ARELS-E-------LAKQFRSQ-QT------------------QENVT---SSCAEDGIE ----FKFIPPRSPNFGGLWEAGIKSMKTHLKATLG--N-----SIL----SADQL----- --TTL-----LSQIESCMNSRP--------LTQ------------L-------------- ----------------------SA--------DPD--D-------LDVLTPGHF------ ----------- >215/1-535 ---PTKRQVLSLVASMFDPLGLAAPVIVVGKMLMKN-IWSE-K----------I------ -DWDE-Q-LTE--ELKKCWNYFLKCLSDVK---K-IKIP--RQV--V------------- --AP-G-AT--AF-EIHG-FGDASLE-AYG-ACVYIR--SIVP-GS------LPVV-K-- ILTA---------------------------KSKI-VPK-------S------------- ---V----------------------------LTIPRKELLAAL-LLH-RLVIKVIAT-- -L-K----M-S-F---RQV---VL---------WS------------------------- -------------------------------------WYLPHHAV-------LRPS-NTT TKC-RVVFDASAKV--KG---LSLNDVMMIGSLNQ--CALDEIALRFR---IPCY--VLT TDVAKMYRQVLVDKN--HRRLQR-----I------FFRLD---P-SS---------PL-R VLELKTVTYGTASAPFLATRA-LLQL------------A----NED-GHKF--P-LAAEI V-KTC--FYVDNA-LFGFD-D---IGKALEAQSQLI-QL-LEGG-------GFHLH-KWA SNCS-EL-MA-------------------------------------------------- ------------------------------------------------------------ --------------------SI-------------------------------------- ----------------------------------------------------------DR APAFQRVGLDFAGPFL-------------------------------------------- ----------------------------IK--QTGRKA---APV------KG-YVC---I -FICMV--TKGIHLEAVENLTSDAF-----IGALQRF-VSRR-GVPEELFSDNGTNFVGA KKELH-E-------LFNLFKEQ-AT------------------ERKIF---EFCQPREIR ----WKMIPPGSPHMGGLWEAGVKSTKSVLKKTCN--T-----ASL----TMMEF----- --STL-----LCQIEALLNSRP--------LYA------------H-------------- ----------------------SE--------DAL--D-------PEPLTPGHF------ ----------- >216/1-571 ---WTRRKVYSVIAQLWDPSGITAPVISWAKIRMQV-LWIA-V----------Q------ -GWDD-P-LSK--ELSDQWTKFYEQLPALV---N-IKVE--RRA--F------------- --TN-H-PM--LV-QFHV-FSDASEA-AYG-ACIYAR--SIDQ-SG------QIKV-E-- LLAA---------------------------KSRP-AAL-------K------------- ---K----------------------------TTLAKLELCGAH-IAA-KLYRATVKA-- -L-K----M-E-D---TET---WF---------WS------------------------- ------------------------------KDDKRLVCYLPHHPV-------IKEA-SST TKV-RPVFDGSAKTT-SN---HSLNEALMVGPVLQ--DPLFDLVLRFR---KHSV--ALV GDIEKMYLQVKVHPD--DTPLQR-----I------LWRFS---P-SE---------PI-T TYEMNRVTFGLAPSSFLATRC-LHQL------------A----EDE-GDQH--P-RAKAA L-TND--FYVDDY-IGGAN-S---EEEALALRQELE-QL-MPKG-------GFRLR-KWV SNAK-RV-LEGLAVEDLGTQS--T-L-NF----------------------------D-- -QEQV-----------------KT--LG-------------------------------- -----IHWQPGPDLLGIDV----------------------------------------- ----------------------------------------------------------TP ARAFTVTGVDYCGPVY-------------------------------------------- ----------------------------LKPV--HRRA---AAQ------KA-YIA---V -FVCFA--TKAVHLELVGDLTTAAF-----LAALRRF-VARR-GLPSEIHSDNGLNFKGA SNYLR-E-------LYDLLHDP-DA------------------KTAIS---NETSRQGIV ----WKFIPPRAPNFGGLWEAAVKSAKTSLVRVLG--Q-----QKL----SFEDM----- --TTI-----LTQIEAVMNSRP--------LTP------------L-------------- ----------------------SE--------DPD--E-------F-------------- ----------- >217/1-560 ---TTKRIVLSSVMSLFDPLGLLAPFTTQGKMLIQD-LWRS-G----------C------ -DWDQ-A-IDD--DSYKKWRSWVSVLPKIA---D-LEIP--RSY--F------------- -GMVQSK-DFGHI-QLHI-FTDAGEN-AFG-CAGYLR--IVVD-GV-------VKC-S-- LAMA---------------------------RSKV-APL--K-Q---------------- --------------------------------LTIPRLELQAAV-LGA-RMSHQIKQN-- -L------S-LQL---HQT---FF---------WT------------------------- -------------------------------------WYLPLNVV-------LNPK-K-P NKV-RLVWDAAAT-V-GG---VSLNSNLLKGPDLL--TSLPSVISKFR---ERPV--AIG GDIREMYHQLRIRDS--DKQAQR-----F------LFRFN---S-TE---------P-PG IYIMDVATFGATCSPCSAQFI-KNRN------------A----LEH-SEQY--P-EAALA I-VDR--TYVDDY-FDSLD-S---EEEALRRAKEVK-FI-NAKA-------GFEVR-NWS SNSS-LV-LCGL--GE-----EKSSGLVHFHQ-----------------------D-KAT EN--E-----------------RV--LG-------------------------------- -----IIWNPRLDVLSFAV----------------------------------------- ----------------------------------------------------------PY KRPFTFVGIDYLGPVD-------------------------------------------- ----------------------------VS--VG-R-----R-AE-----KR-WIV---L -FTCLV--VRAVHLEVAYNLTAQSC-----TMAIRRF-ICRR-GPAAEYFSDNGTNLKAA SKEFV-E-K------LQE-IGS-E----------------------CA---EEFTTARTK ----WHFNPPATPHMGGIWERMVRTVKNVMAV-LN--D---G-RRL----TDELL----- --LTT-----LAETEDMVNSRP--------LVY------------APQGSPQES------ ------------------------------------------------------------ ----------- >218/1-552 ---PTKREVLRVVMSIFDPLGLVAAFVVHGKCLIQD-IWRA-G----------V------ -DWDD-Q-IPA--ELANQWWRWVEVLRNLN---I-VKIP--RCY--F------------- -PGYDSH-SLRSI-ELHV-FVDASET-AYA-CAAYFR--IVD--RG------QVRC-T-- LVSA---------------------------KTKV-APL--K-P---------------- --------------------------------MSVPRLELQAAM-IGV-RLMKSVQEN-- -H------T-LPI---TRR---LI---------WG------------------------- ---------------S---------------SDPNRVWYLPLGVV-------QNPN-K-P GKV-RVVWDAAAK-T-SG---VSLNSMLLAGPDLL--TSLPSVLFRFR---QRQI--AIT GDIKEMFHQIIIRPE--DRQAQR-----F------LWRNN---P-NE---------P-VQ EYVMDVATFGSTCSPCSAQYV-KNKN------------A----EEW-KHVY--P-EAATA I-VEN--TYVDDY-ANSSD-T---VEEAVRVALEVR-EI-HASA-------GFEIR-NWL SNSQ-QV-LRRV--GE-ESSK----TTKSFTA-----------------------V-KAT DS--E-----------------RV--LG-------------------------------- -----MMW---------------------------------------------------- ----------------------------------------------------------PY VRPFTFIGIDYCGPFL-------------------------------------------- ----------------------------IR--IG-R-----S-SV-----KR-WVV---L -ITCLT--IRAVHLEVAASLSTESC-----KMAIRRF-IARR-GAPQEIYSDQGTNFIGA SRELR-A-E------VTA-VNR-E----------------------LA---GTFTNHDTQ ----WRFNPPAAPHMGGVWERLVRTVKTSLQT-LS--T---S-RTP----DEETF----- --QTL-----LIEIEGIINSRP--------LTF------------V-------------- ----------------------PL-------------DT--------------------- ----------- >219/1-564 ---PTMRNMYKTLASQYDPLGFIIPFTTRAKVLIQD-LWKQ-N----------L------ -GWDD-LIEPA--QLRNKWLTWVGEIPTLL---Q-LQFP--RLY--T------------- -PVWPDN-PPVTR-ELHI-FCDASER-AYG-SVAYLR--ASDD-QG------HVAV-T-- FVLA---------------------------RSRV-APR--K-C---------------- --------------------------------LSMPRLELSAAL-TGA-QLAQVIQNE-- -L------T-LPI---DSV---TL---------WS------------------------- ---------------A---------------NKSNESWYIPHHVV-------HHN----- NKD-RIVFNCSFQ-H-QG---QSLNSQLLPGPTLG--PSLLGVLLRFR---QHAV--AVS GDIKGMFHQVRLLPK--DKQVLR-----F------LW-RD---MCRD---------REPD IYEWQVLPFGTTCSPCCAIFA-LQHH------------A----QGH-KGD---MPKLVNI V-ENS--FYVDNC-LYSTP-T---ANEAKDVVDGLR-QL-LAEG-------GFDLR-QWA CNVP-SV-IQHL-------PAEALSTNSERWL-----------------------TK-ST -DLQE-----------------PT--LG-------------------------------- -----LRWNCLNDSLGYN-----------------------------------------L ----------------------------------------------------------LY KPPFYSTGVDCFGPFT-------------------------------------------- ----------------------------VK--VG-R-----R-QE-----KR-WGV---L -YKCMT--TRCVHLDLLEQLDTDAF-----LLSLRRF-IARR-GKPMELLCDNGTNFVGG DRELR-E-------TFNAMAPK------------------------LQ---EQLAEQRIR ----FRFNPPSAPHFGGTWEREVKSVKSALRVILR--E---Q--SV----PEAVL----- --QTL-----LVEVEGILNSKP--------LGY------------I-------------- ----------------------SS-------------DV--------------------- ----------- >22/1-556 ----TKRIVCSELAKIFDPLGLFGPVVTTAKIRMQQ-LWEL-K----------I------ -DWDT-E-LGS--ELTHQWQAFRHDVQILT---T-IRIP--RCA--L------------- --PADT-SG--GI-QLHV-FADASEA-AYG-AVAYLR--ARDK-TG------NIVT-R-- LLCS---------------------------KARV-APL--M-K---------------- --------------------------------QTLPRLELCAAV-LAA-QVTKRVKTD-- -L-N----V---N---LEAI--HL---------WS------------------------- -----------------------------------NHYVIPHHCV-------LKPD-SST TKL-RVVFDASATTT-SG---KSLNNLLRIGPTVQ--SELLSILLRFR---SYQY--VFT SDVEKMYRQIMIHPD--DRKFQI-----I------LWRRN---L-ME---------PL-K YYQLNTVTYGTATAPYLATRC-LQYL------------S----DTA-PEHL--S-QGAAA L-RQG--CYVDDC-LTGGH-T---IDEALIKRDQLI-QL-LGEA-------KFKLR-KWC ANHP-AL-LADIPEED--QEMTLD-FSNFT------------------------------ -EQTV-----------------KT--LG-------------------------------- -----IIW---------------------------------------------------- ----------------------------------------------------------QQ HRPFKNCGVDYCGPFW-------------------------------------------- ----------------------------THYK--IRGK---RPH------KV-YLA---V -FCCFS--TKAVHLEVVTDLTTQAF-----LAALKRF-CGRR-GLPSKIYSDNATNFVGA YNELS-E-------VKEAIFAE-EA------------------QAMIH---KTCANLSIE ----FKFIPPRAPHFGGLWEAAVKSAKHLLKRTLY--T-----ATL----THEEL----- --ETI-----VIDVEAILNSRP--------LTS------------V-------------- ----------------------SS--------SPR--D-------L-------------- ----------- >220/1-516 ----TKRSILRFVMSVFDPLGLISNLLIHGKIIIQD-LWRA-K----------V------ -GWDE-A-IPS--DVLEDWKRWIKKLSELS---Q-TRIP--RCY--F------------- -PGYNPD-SLQTL-ELHI-FVDASES-VYA-CVAYFR--IID--NG------QPRC-A-- LIAS---------------------------KAKV-API--K-P---------------- --------------------------------LSIPRLELQAAV-IGS-RLAKSISEY-- -H------T-IAP---SRR---FL---------WS------------------------- -------------------------------------WYLPLGVV-------TNPR-K-P GKV-RIVWDAAAK-V-NG---VSLNGTLLKGPDLL--TSLPTVLCRFR---QRQI--AIA GDIREMYHQLKIRKE--DQQVQR-----F------LYRSD---P-SM---------K-PE VFVMNVATFGSTCSPCSANFV-KNTN------------A----MEC-KAEF--P-EAAAA V-VEN--HYVDDY-LDSRD-T---EEAMAKLASEVR-EV-QQSA-------GFELR-NWR SNSK-QV-LQ-------------------------------------------------- ------------------------------------------------------------ -------I---------------------------------------------------- ----------------------------------------------------------PF VRPFSLVGVDYFGPYM-------------------------------------------- ----------------------------IK--IG-R-----S-QV-----KR-WVA---L -FTCMV--IRAVHVEVAASLSTESC-----KLAIRRF-IARR-GAPTQIYTDHGTNFVGA SRELA-N-Q------LAT-MNR-E----------------------LA---ETFTNTNTR ----WFFIPPSSPHMGGAWERMVRSVKTAMEV-IN--E---F-RAP----SEEVF----- --HTI-----ICEAESIVNSRP--------LTY------------V-------------- ----------------------PL-------------ET--------------------- ----------- >221/1-540 ---PTKRIALRCIMSMFDPKQFLAPVLIHGRILMQD-LWRS-G----------I------ -GWDE-K-IEK--AHYDRWLRWTGLFPLID---N-ISIP--RCY--L------------- -GKMSSN-TYDTV-QLHV-FADAGED-AYG-CVAYFR--FTDG-EN-------VHC-A-- FVES---------------------------KAKV-APL--Q-H---------------- --------------------------------LSIPRKELEAAV-LGA-RLLKAISEN-- -H------S-FEL---KRR---FL---------WT------------------------- -------------------------------------WYLPLNYV-------VNAK-K-P GKV-RMVWDAAAR-T-NG---VSFNDSLLKGPDLM--TSLSGVINGFR---ERKV--AFG GDIREMFHQILVRQE--DKQAQR-----F------LFRYD---V-NS---------E-PD IYVMDVVIFGASCSPCLAQFV-KNLN------------A----QEH-QKNY--P-IASDA I-VRK--HYVDDY-FDSAD-T---ESEAIAIAKDVR-EV-HANA-------GFEIR-NWV SNSP-KL-LKEL--GE------A-DSNMTKSF-----------------------D-TAS DA--E-----------------RV--LG-------------------------------- -----VMW---------------------------------------------------- ----------------------------------------------------------VN EHPFSYVGLDYFGPIE-------------------------------------------- ----------------------------VT--VG-R-----R-RE-----KR-WVA---L -FTCMT--VRAVHLEAVHSLTTQSC-----EMAIRRF-VKRR-GSPVEIFSDNGTNFVGA NRDLA-E-Q------IRT-INA-E----------------------CA---DTFTGARTK ----WTFNPPAAPHMGGVWERMVRSVKEAMAV-FA--D---G-EKL----TDEIL----- --QTT-----LVEAETLINSRP--------LTY------------V----S--------- ------------------------------------------------------------ ----------- >222/1-575 ---PTKRSILSDIARLFDPLGLIAPVVVTAKILMQE-LWSL-S----------C------ -DWDE-P-VPH--TVRLKWENFRNELPKIA---C-YRID--RYA--F------------- --LP-E-AR---I-ELHT-FADASTS-AYG-ACTYVR--CENA-LG------TVKI-R-- LLAS---------------------------KSKV-APL-------K------------- ---R----------------------------LTIARLELCACV-LAA-HLYHRIKDS-- -I-N----V-H-V---SAS---YF---------WS------------------------- ------------------------------DGNHSQTYYLPHHPV-------IKEE-STT TKV-RVVFDGSARTS-TG---FSLNEALCVGPVVQ--DDLLTIILRFL---TYPV--ALV GDIAKMYRQVVLHPD--DCPLQR-----I------LFRFS---K-DT---------PI-E TYELRTVTYGLSPSSFLATRT-LQQL------------A----KDE-GDKY--P-LAGPS I-PKN--FYVDDY-IGGAN-S---IEEAIQLRGELS-EL-LVKG-------GFVLR-KWA SNRL-EV-LRGLEDDQIGTQS--S-LSQFY---------------------------P-- -NESI-----------------KT--LG-------------------------------- -----ICWEPETDQLRFES--------------------------QIQ------------ ----------------------------------------------------------IP SRPFSNTGVDYAGPLY-------------------------------------------- ----------------------------LKPI--HKRA---APA------KA-YLC---V -FVCFT--TKAVHLELVGDLSTQGF-----LAALRRF-ISRR-GIPAHLYSDNGKNFEGA KRELA-E-------LFARFRSN-DE------------------QSVIA---SACSEQGIT ----WHLTPPKAPHFGGLWEAAVKTAKRHLFRQLG--N-----TRL----SFEDY----- --YTI-----LHQIEAAMNSRP--------LLP------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >224/1-545 ---ATKRSVLRFVMSVFDPLGLIAHLLVHGKMIIQD-LWRA-Q----------V------ -GWDD-T-IPA--NIFENWERWIKQLSNLS---E-IRIP--RCY--F------------- -PGYDQD-SFRSL-QLHI-FVDASEF-AFA-CVGYFR--IID--RG------QPRC-A-- LIAS---------------------------KAKV-APL--K-P---------------- --------------------------------LSVPRLELQAAV-IGS-RLAKSIAEN-- -H------T-LPV---SRR---FF---------WS------------------------- -------------------------------------WYLPLGVV-------TNPR-K-P GKV-RIIWDAAAK-A-NG---VSLNDMLLKGPDLL--TSLPAVLCRFR---QRQV--AIA GDIREMYHQLKIRKE--DRQVQR-----F------LYRND---P-SK---------K-PD IFVMDVAIFGSTCSPCSANFV-KNTN------------A----MEW-QEEL--P-EASAA V-IEN--HYVDDY-LDSRD-T---EEELAILASDVR-KI-QQNA-------GFELR-NWR SNSL-KV-LQII--GE-SATE----TKKEFNA-----------------------D-KAT QV--E-----------------RV--LG-------------------------------- -----MAW---------------------------------------------------- ----------------------------------------------------------PF VRPFSLVGIDYFGPYL-------------------------------------------- ----------------------------IK--IG-R-----S-QV-----KR-WVA---L -FTCLV--VRAVHLEVVASLSAESC-----KFALRRF-IARR-GAPTQIYSDHGTNFVGA SRELA-A-Q------IAT-MNR-E----------------------LS---ESFTDAKTR ----WFFIPPSSPHMGGAWERMVRSVKAALEA-VN--C---S-RTP----TEEIF----- --QTI-----LCDAESMVNSRP--------LTY------------M-------------- ----------------------PL-------------ET--------------------- ----------- >225/1-550 ---PTKRLALSCMMSLFDPLGLLAPFTLHGKILLQD-LWKS-G----------C------ -NWDE-E-IND--ECFKKWTWWRNTLSSIE---N-LQIP--RCY--L------------- -KGSSAA-GYDNL-QLHV-FCDGSSQ-AYG-CAAYFR--LETP-GG-------IIC-S-- LVMA---------------------------KTKV-APL--K-Q---------------- --------------------------------LSIPRMELQAAV-LGA-RLANAVIAN-- -H------R-VKV---AKR---IL---------WS------------------------- ---------------N---------------ANQARVWYLPLNVV-------LNPK-K-P GKV-RLVWDAAAQ-V-RG---ISLNSMLLAGPDLL--VPLPAVLQPFR---ERAV--AFG GDLKEMFHQFNIREG--DKQAQR-----F------IFRTD---R-EK---------D-PE VFVMDVGTFGATCSPASAQFI-KNHN------------A----AKY-AVQY--P-EAARS I-IRL--HYVDDY-LDSAD-S---IDEAVKRAKEVR-FI-HSQA-------GFTIH-KWI SNSP-RF-LEEI--GE-----RNTEEKISLQL-----------------------D-EGS T---E-----------------RV--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------PF VRPFSYVGIDYFGPVD-------------------------------------------- ----------------------------VV--VG-R-----H-GE-----KR-WIV---L -FTCLS--VRAVHLEVAYKLDTASC-----IMAIRRF-VLRR-GPPITIFSDNGTNLKAA NKELQ-E-Q------IKR-IDT-A----------------------CA---NVFTNARTR ----WRFNPPSAPHMGGVWERMVRSVKQVMSE-LN--T-----GRM----NDETL----- --LTV-----ITEAEEIVNSRP--------LVY------------M-------------- ----------------------PQ-------------DS--------------------- ----------- >226/1-562 ---YTKRKVFSEIGRLFDPLGLVSPVIVVAKILMQK-LWMS-G----------L------ -SWDE-T-LEG--DLLLSWMKFCDALPQMS---Q-IKIP--RRV--F------------- --LC-N-AV--AI-EIHG-FSDASIS-AYG-AVLYVR--TVFS-DG------RAEM-R-- LLCS---------------------------KSRV-API-------S------------- ---E----------------------------LSIPRKELLAAQ-LLS-RLVGKVVGS-- -M-K----V-K-F---DDV---TL---------WS------------------------- ---------------------------------------LPHHAV-------LRPT-SST TKL-RVVFDASAKCNPSD---KSLNEVLQVGGVVQ--SDLLSILLRFR---VHPV--VFT ADIAKMYRQILVSEE--HTRFQR-----I------FWRSE---S-NQ---------RL-R VLELLTVTYGTAAAPFLATRC-LVQL------------C----HDE-GNKY--P-IASNI I-IED--CYVDDV-LSGAD-T---VEEAIEAQRQLE-DL-LHLG-------GFPIH-KWS SNCQ-EL-LENIPEENREKLV------RLD---------------------------QTS TDEVI-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TP AHPFEITGVDYAGPVF-------------------------------------------- ----------------------------VK--QGRRKP---VVE------KA-YIS---V -FVCMV--TRAVHLELVSDMTTEAF-----IAALQRF-VSRR-GLPREMHSDNGSNFRGA KAELN-E-------LYKLFRSQ-SA------------------VDKIE---GFCLSKEIA ----WYFIPPEAPNFGGLWEAAVKSAKYHLKRTLK--D-----TNL----TFEEY----- --VTV-----LTQVEAILNSRP--------LYA------------T-------------- ----------------------TP--------DPD--D-------PEVITPGHF------ ----------- >227/1-568 ---STRRGILSVISSLFDPIGFVAPFILQGKCILQE-LCRK-N----------I------ -GWDD-Q-LPE--DMYSRWEDWKGGLQRLK---E-VVIP--RCY--H------------- -PDTFNE--IIET-ELHH-FSDASNI-GYG-ACSYLR--FKND-KG------KVHC-S-- LVMA---------------------------KARV-APT--K-V---------------- --------------------------------TSIPRLELAAAV-LSA-KISVMLKTE-- -L------E-MKI---DRE---FF---------WT------------------------- ---------------------------------GETVWYIPHHGV-------YHPQ-K-P GKL-RVVFDCSAK-F-SG---ISLNDTLLTGPDLI--NSLVGVLCRFR---KELV--AVT CDIEKMFHQFLVPPD--ERNYLR-----F------LWWED---GDWE---------KEPQ DYRMTVHLFGATSSPGCANFG-LKYL------------A----QQY-EVKH--PTAS-EF V-KRN--FYVDDG-LASVR-S---IDEAKELITDAQ-AL-CKQG-------GLRLH-KFN SNKE-DV-LCCI-------DPSERDIVSKPLN-----------------------LNPEA -TPTG-----------------RV--LG-------------------------------- -----VQW---------------------------------------------------- ----------------------------------------------------------EV SAPFTFCGMDCFGPFV-------------------------------------------- ----------------------------VK--RA-R-----K-EY-----KR-YGL---I -FTCLS--SRAVHIEMIEDLSTDAF-----INALRCF-ISLR-GAVCKLYCDQGTNFVGA RNEFK-D-------CLKQVDIK-T----------------------LE---VFLAEKQCE ----FAFNAPSASHTGGVWERQIRTVRSVLNATIA--L---CPGRL----DDASL----- --RTL-----FYEAMAIVNSRP--------LTV------------D-------------- ----------------------GI--------N----DPNSLEPLTPNHL---------- ----------- >228/1-522 ----TMRNIYRVLASQYDPLGYIIPFTTRAKIIVRQ-LWAK-E----------R------ -EWDD-PLLPS--ELLQAWQNWEAELNHLP---K-ITMP--RCY--V------------- -SATLDV-PEAER-ELHI-FCDASAE-AYG-SVAYLR--TEH--QG------QIEL-A-- FIHA---------------------------RSRV-SPK--R-Q---------------- --------------------------------QSVPRLELCAAL-TGA-QLAKLLHNE-- -L------S-LKI---KDT---FL---------WS------------------------- ---------------A---------------AQSTESWYLPHHIV-------THN----- GKH-RVVFNCSYT-Y-NG---ENLNKQLLPGPTLG--PTLLGVLIRFR---EHRV--AIS GDIKGMFHQVRLLPK--DKPLLR-----F------LW-RD---LNPE---------NPPD VYEWQVLPFGTTCSPCCATFA-VQRH------------V----FSH-CQQ---GDKLRQS V-EHS--FYVDNC-LQSTS-S---AVEARELIDGLR-SI-LASG-------GFEIR-QWA SNEA-TV-VRH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LM KPPFFSTGVDCFGPFL-------------------------------------------- ----------------------------VK--RG-R-----S-NE-----KK-WGI---I -FKCMT--TRCVHLDLLANMDTDSF-----LMALRRM-VARR-GTPSEILADQGTNFRGG DKELQ-T-------AFTAMSPD------------------------LQ---AQLAKQKIQ ----FHYNPPNAPHFGGMWEREIRSVKAALRTIIG--P---Q--TL----TEEVL----- --RTL-----LIEVEAILNAKP--------LGY------------V-------------- ----------------------SS-------------DL--------------------- ----------- >23/1-584 ---PTKREYLSLVMSTFDPLGFLCCLMITAKLLLRE-IWRQ-K----------I------ -QWDE-P-LPE--ELSKAFAIWRKEMDAVG---Q-FRCP--RHY--F------------- -GRGAVR----AI-ELHV-FVDASQA-AFA-AVAYWR--VTYE-DD------DVQV-S-- FVSA---------------------------KTKC-APM--R-T---------------- --------------------------------MTIPRLELQAAV-LGT-RLMNTVKEE-- -H------S-VVI---TDL---VL---------WT------------------------- ---------------A---------------VRSDRLWYLPHFGV-------ENPN-K-P GKV-RLVFDAAAK-V-GG---TSLNSELDKGPQHY--KPLPAVLFHFR---EGAV--GVC GDIKEMFHQVLIRPE--DRCSQR-----F------LWRDG---D-DE---------RDPD VYEMNVMTFGAACSPSAAHYV-KTMN------------A----LKY-RDSD--P-RAVKA I-TDY--HYVDDY-VDSFA-T---ESEAISVSTRVK-EI-HKDA-------GFELC-QFS SSSP-TV-ETAL--GPG-RVKSVGWGEAE------------------------------- ----E-----------------KI--LG-------------------------------- -----MRWQVATDDFRFNVEYHRVPSSVLSGDRVPTKREYLSLVM--------------- ----------------------------------------------------------AG GWPFKYTGLDYFGPLL-------------------------------------------- ----------------------------VT--VS-R-----H-KE-----KR-WVA---L -FTCLT--TRAIHLELAHDLSTDSC-----IIAIRNF-VCRR-GPVYRLRSDNGKNFVGA DREAR-R--------FGDVFEMEK----------------------IQ---SELSSRSIE ----WVFNCPANPSEGGVWERMVQCVKRVLRHTLK--E-----VAP----RDHVL----- --ESL-----LIEAENIVNSRP--------LTH------------L-------------- ----------------------PV-------------DA--------------------- ----------- >230/1-562 ---PTKRTMYSEIAKFFDPLGLVSPVIVLAKLLAQK-LWQL-K----------T------ -EWDD-P-VDD--DTAQQWQELQDSLTHLH---E-IKIP--RRV--T------------- --FD-N-AV--AH-ELHG-FSDASNK-AYG-ACIYLR--SIFA-DG------SAKL-R-- LLTS---------------------------KSKL-APL-------K------------- ---E----------------------------ISIPRKELCAAL-LLT-RLVQKVLPA-- -L-D----M-S-F---RDI---VL---------WC------------------------- ---------------------------------------LPHHAV-------LRPS-SSS TKC-RVVFDASAKSSPSD---LSLNDVLQVGPVVQ--NDLHHIALRFR---KFKV--AFT GDIAKMYRQVLQAPC--DRRFLR-----I------FWREH---P-AM---------PM-R VLELCTVTYGTASAPYQATRC-LVQL------------V----EED-GEDF--P-IAARI V-KED--TYMDDV-LSGAD-S---LEDAIEAQQQLK-QL-LGRG-------GFPIH-KWC SNSQ-EF-LEHIPVEEQEKKT------VLE---------------------------EHG VNEAI-----------------KV--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------VP SPPFAVTGVDYAGPFW-------------------------------------------- ----------------------------TK--QGTRRP---TLV------KS-YVA---V -YVCMA--TKAVHLEGVSDLSTDAF-----LASLRRF-IARR-GMVHEIHSDNATNFRGA DHELK-Q-------LHQQFHDQ-QT------------------VKIIE---SFCHNHEIE ----WHFIPPDAPEFGGLWEAAVKSAKTHLKRVAG--N-----TSL----TFEEM----- --CTL-----LAEIEAVLNSRP--------LFT------------I-------------- ----------------------SN--------DSA--D-------PLVITPAHY------ ----------- >231/1-548 ---PTKREILRTLMTIYDPLGLIDHFLILLKILLQE-VWRA-N----------V------ -GWDE-Q-IPE--NLFDKWRDWLRMLTALE---K-LRIP--RCY--R------------- -QVVSSL-NTAAV-EMHI-FVDASES-AMA-AVVFLR--FVE--DN------QVEC-S-- LVAA---------------------------KTRV-APL--K-Y---------------- --------------------------------TSIPRLELQAAV-LGT-RLAKSVYGN-- -L------T-MTI---TKR---TF---------WT------------------------- -----------------------------------RIWYLPIFPV-------YNPN-K-P GKV-RIVWDAAAE-A-YG---VSLNSALLTGPDQL--ASLVGILYQFR---EHRI--GLC ADIREMFHQVRIVPE--DQHCQR-----F------LWRDR---D-EH---------GEPN TYIMQVMTFGASCSPATAQFV-KNRN------------A----DRF-EEES--P-AAVAI I-KKR--HYVDDM-VFSVE-T---EAEAVELAESVR-FI-HMQG-------GFEIR-NWV SNSP-MV-LSKM--SG---EVTS---EKDLNI-----------------------TAE-L AN--Q-----------------KI--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY TRPFAHVGVDFFGPIE-------------------------------------------- ----------------------------VS--VG-R-----R-VE-----KR-WGV---L -LTCLT--VRAVHIEVAHSLTTSSC-----IMALRNF-TARR-GTPVSFYSDRGTNFVGA NREIL-E-------TVKKIDQN-Q----------------------LM---REFVTSSTA ----WQFNPPAAPHMGGSWERLIQSVKRNLSEVLH------A-RRP----TDEEL----- --RNA-----LTEIEGVLNARP--------LTH------------V-------------- ----------------------PI-------------DD--------------------- ----------- >232/1-581 ----TKRQVLCYIARLFDPLGLLGATITSAKVFMQR-LWCL-K----------N-EAGSI LQWDD-P-LPE--MVGEEWRTFHKQIPMLN---E-IRIP--RCV--I------------- --SP-N-SV--SV-EYHC-FSDASIV-AYG-ATIYVR--SQRD-DG------SVSV-H-- LLTS---------------------------KSKV-APL-------K------------- ---V----------------------------QSLPRLELCGAL-LVS-QLWEKVAES-- -L-K----A-E-----EKV---HF---------WT------------------------- ------------------------------EEKAVKRCFLPHHPV-------IKES-STT TKV-RVVFDASCKTS-TG---VSLNDALYAGPVVQ--QDLRSIVLRSR---IRQI--MVV ADVEKMFRQIWTSLE--DTPLQC-----I------LW-ST---P-DG---------KV-V PFELLTVTYGTKSAPYLATRT-LKQL------------A----FDE-RERF--P-LAAPT I-EED--VYMDDV-ISGAD-D---VESAIELRRQVD-AM-MDSG-------GFKLR-KWA SNRP-EV-LEGIPCENLALPDSNG-I-DWD---------------------------Q-- -NAEV-----------------KA--LG-------------------------------- -----LTWLPNADQFRFKFEVPPI------------------------------------ ----------------------------------------------------------TV SRPFSKSGVDYFGPVY-------------------------------------------- ----------------------------LRAG--RGRK---P-T------KA-YVA---I -FVCMA--TKAVHMELVSDLSTERF-----LQALRRF-FARR-GRCTDIYSDNGTNFVGA RNQIQ-E-------LFDLLKES-TH------------------RETVS---RECANEGIY ----WHFNPPSAPHFGGLWEAAVRSAKFHLLRVLG--G-----NPV----SQEDF----- --VTL-----LTQVEACLNSRP--------LTS------------L-------------- ----------------------SD--------DPL--D-------L-------------- ----------- >233/1-558 ---PTKRQILSTLMMIYDPLGLLSNFLMFLKMLLQE-IWRS-R----------V------ -DWDD-Q-IED--EQFQKWGRWLRVLPQVE---N-VSVP--RCY--R------------- -LKTSIG-QQNTI-QLHT-FVDASEN-GYA-AVAYLR--FEE--NG------VVEC-A-- LVGA---------------------------KARV-APL--R-F---------------- --------------------------------VSIPKLELQAAI-TGA-RLANDVMET-- -H------K-LKP---VQR---FF---------WS------------------------- -----------------------------------RVWYLPIFPV-------VNPN-K-P GKL-RIVWDAAAK-V-AG---TSLNSFLLSGPDQL--TSLPSVLRRFR---EYRI--AVT GDIREMFHQVMVNKD--DQQCQR-----F------LWRDG---E-ND---------RSPD VYAMKVMTFGATCSPSCAQYV-KNHN------------A----RRF-LEQF--P-RAAEA I-VDE--HYVDDM-LSSEE-T---EEDAVKLAKDVR-FV-HAEA-------GFEIR-NWL SNSK-RV-LQEL---E---AKPG---EKSLNL-----------------------SSE-L GT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF CRPFSYIGIDYFGPMN-------------------------------------------- ----------------------------VV--VG-R-----R-IE-----KR-WGV---L -ITCLT--VRAVHIEVANSLTTDSC-----ILALRNF-IARR-GTPLEIISDRGTNFVGA SRELK-E-------ALQQVNQD-K----------------------LM---EHFVTADTK ----WSFNPPASPHFGGSWERLVQTVKKALKHTQL------T-RTP----TDEIL----- --RNM-----LTEIELIVNSRP--------LTE------------L-------------- ----------------------PL-------------DDEHAQSLTPNHF---------- ----------- >234/1-535 ----TKQKIFSIIASLFDPLGFIGPVITQAKIIMQL-SWQL-L----------D-DKGQK LAWDS-P-LPS--KVEEEFRRFYQQIPLLN---D-LRIE--RLV--V------------- --TP-Q-AT--QT-QLHI-FSDASEK-ALG-ACVYVR--TADS-SG------RIKV-A-- LLLS---------------------------KSRV-APL-------K------------- ---T----------------------------QTIPRLELRAAT-LAA-EMYSQVMDS-- -V-E----T-P-----IET---FF---------WT------------------------- ------------------------------E-----RCYLPHHPV-------VKEG-STT TRV-RVVFDASARTS-TG---LSLNDCLHSGPVIQ--RDLRSIILRSR---FRPI--MLV ADIEKMFRQVDVCPE--DRRFQS-----I------LWRPS---P-DQ---------PL-A TYELKTVTYGTKPAPFLATRT-LVQL------------V----NDE-AERF--P-LASAT V-KND--FYMDDA-ITGAN-D---SLTAKDLRIQLV-DM-LQSG-------GFKLR-KFA SNCP-SV-LEGIPN---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VP AKPFSTTGVDYFGPIY-------------------------------------------- ----------------------------VRPG--YRRT---A-V------KA-YVA---V -FVCFS--TKAVHLELATDLSTACF-----IQALRRF-ISRR-GKCVQLFSDNGTNFVGA KNAME-K-------LLQNLRSK-EH------------------NEAVS---KWCTDEGMQ ----WSFIPPGAPHFGGLWESAVRSTKVHLLKVLG--D-----TAV----SYEDM----- --TTL-----LAQVECCLNSRP--------LTP------------L-------------- ----------------------SD--------DPE--D-------L-------------- ----------- >235/1-516 ---PTKREVLKILMTLFDPLGFIAFFLIHGKVLMQD-IWAS-G----------C------ -DWDE-Q-INE--ALCIRWKQWTRFFPQLD---A-LRIP--RCY--F------------- -KSLVPG-DKNQL-QVHV-FVDASEG-AYA-CVAYFR--LAT--GE------DVSV-S-- LIGA---------------------------KSKV-APL--K-S---------------- --------------------------------LSIPRLELKAAV-LGV-RYLESISNQ-- -H------S-FKV---HQR---YM---------WS------------------------- -------------------------------------WYLPLGVV-------VNPK-K-P EKI-RLIWDAAAK-A-SG---ISLNSQLMKGPDFL--SSLTAVLIQFR---HFPI--AVS GDIREMFHQLKMRAE--DQQSQR-----F------LWRED---P-SE---------R-PE IYVMDVATFGATCSPASAQYV-KNVN------------A----AAF-SDQY--P-RAVIA I-QKY--HYVDDY-LDSFE-T---IQEAKQVVKEVR-TI-HAEG-------GFELR-NFR SNSS-EL-LRSI------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY VKPFTSVGLDYFGPLL-------------------------------------------- ----------------------------VR--VG-R-----S-QV-----KR-WVA---L -FTCLA--IRAIHLEVVHSLSTESC-----VMAVRRF-VARR-GSPAEFYTDNATCFQGA SRELQ-E----------E-IGN-K----------------------LS---TTFTSAHTK ----WRFIPPATPHMGGVWERLVRSVKVAAGTILE--A---P-RKP----DDETL----- --ETI-----LCEVEAMINCRP--------LTY------------I-------------- ----------------------PL-------------DS--------------------- ----------- >236/1-551 ---PTKRQVLKCVMSLFDPLGLLACILVHGKIMMQN-IWRS-G----------I------ -KWDD-F-IDE--ITYEAWRKWIGLLDEVN---D-IRIP--RCY--F------------- -QNAGAE-LYLSL-EAHV-FVDASEA-AYA-AMVYFR--IVEQ-DG------TGKC-A-- LVTA---------------------------KTKV-APL--R-Y---------------- --------------------------------VSIPRMELMAAL-LGA-RLFLFVREN-- -H------S-VKI---NRV---VY---------WS------------------------- ---------------R---------------ADPRRIWYLPLGAV-------FNPK-K-P GKV-RLIWDAAAK-V-DG---ISLNSLLLPGPDLL--VSLVSVQFLFR---QYPV--AVS GDIKEMFHQTRVIER--DRPSQC-----F------LFRSN---P-SV---------E-PS VYIMDVLTFGATSSPTSAQFV-KNQN------------A----QEF-GDKC--P-RAADA I-IKR--HYVDDY-LDSFE-T---IEEARTVSSKVK-WI-HAQG-------GFEIR-NWS SNEK-AV-LEHL--GDQ----PRKE-TKDLSL-----------------------K---D DT--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------PG IRPFTYIGVDYFGPIL-------------------------------------------- ----------------------------VK--VN-R-----S-VA-----KR-WVC---L -ITCLT--VRAVHLELAHDLSTKSC-----IACLRRF-IGRR-GSPKEIYSDNGRNFIGA NRVLR-D-Q------IHL-IEQ-D----------------------VA---TTFTNTETK ----WIFTPPSCPHMGGSWERMVRSVKKAMASL-P--Q---D-NKL----DDEGL----- --QTV-----LVEAEAIVNSRP--------LTY------------L-------------- ----------------------PL-------------NS--------------------- ----------- >237/1-529 ---PTKRQILRTVMSLFDPLGLLASFLVHGKILMQD-VWRS-G----------I------ -KWDE-R-VDD--RTEQRWHNWIELFARVD---E-IKIP--RCY--F------------- -VAASTE-RYGTL-QAHL-FVDASEA-AYS-AVVYFR--IIDG-EG------NPQC-S-- LVTA---------------------------KTKV-API--K-Y---------------- --------------------------------VSVPRLELMAAV-LGA-RLLAFVGDN-- -H------T-VPI---QQR---FC---------WS------------------------- ---------------E---------------ADPRRTWYLPLGTV-------VNPK-K-P TKV-RLIWDAAAK-V-DG---VSLNTFLLPGPDLL--VSLPAVLFRFR---QYPV--AVC GDIKEMFHQIGVIAA--DRHAQR-----F------LWRET---P-EE---------P-PK VFLMDVLTFGSASSPSSAQFV-KNRN------------A----KEH-EAQF--P-RAAEG I-VKC--HYVDDY-LDSFE-D---EVDAKLVAEQVR-HV-HSNG-------GFEIR-NWS SNSR-VV-LEH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG VRPFSYIGIDYFGPIL-------------------------------------------- ----------------------------VK--VG-R-----S-SA-----KR-WVC---L -ITCLT--IRAVHVEVAFDLSTQSC-----IACIRRF-VCRR-GAPLEIYSDNGRNFVGA DGVLR-E-Q------MKR-IDE-E----------------------AA---ATFTNAQTK ----WCFIPPSAPHMGGSWERLVRSIKAALINI-P--Q---D-RKL----DDEAL----- --LTY-----LAEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------DTPEQE----------------- ----------- >238/1-540 ----TKRAVVSEMSRLFDPLGLLGPVVINARIFVQG-LWAK-R----------L------ -TWDE-Q-LSD--EESQWWQAFREDLANLK---E-ITVP--RHV--V------------- --AN----CGHNY-QLHC-FCDASSK-GYG-SCVYVV--GPNA-AG------EIES-K-- LLIA---------------------------KSRV-APL-------R------------- ---G----------------------------LSIPRLELCAAL-LGS-QLIHNLRTT-- -T-D----F-I-----GTA---VF---------WS------------------------- ------------------------------PSVDGPQFFLPHHAV-------RRPE-STT TKT-RVVFDASSKSH-GQ---LSLNDVLFTGPTVQ--PALLIMVVNFR---LPRY--VFS ADAEKMFRQVWVHPD--DRKFLS-----I------VWRSD---P-SL---------PL-N HYHLKTVTYGLACSPYQAARV-LNKL------------A----EDE-GESY--P-LAAPV I-TKR--FYVDDT-LAGGD-D---LEEVVETCRQLQ-EL-LARG-------GFTLR-KWC ANDP-TV-LRH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VP SRVFSKAGLDYCGPFN-------------------------------------------- ----------------------------IRPL--YGRG---ANV------KM-YVA---I -FVCLV--VKAVHFEIVPSLTSAAC-----INAIKRF-VARR-GRLIELHCDNATAFVGA DRELK-S-------LRRQYIEQ-FK------------------ADEWK---DYCLDSGIT ----FHFIPARSPHFGGLWEAGVKSFKYHFRRIFA--T-----NSY----TLDEF----- --TTA-----ATHIESILNSRP--------LTP------------L-------------- ----------------------TD--------HPD--D-------LAVLTPGHF------ ----------- >239/1-556 ----TKRFVLSTLSKIFDPLGWLAPVTIVGKIFIQK-LWTA-G----------I------ -NWDQ-E-LVN--EDRKEWEEYKSGLEALG---Q-IRVP--RWI--N------------- --FKSE-----LCIQIHG-FADASEK-AYA-AVVYAK--V------------GSEV-I-- IIAS---------------------------KSKV-NPI-------K------------- ---NR---------------------------KTIPKLELCAAH-LLS-KLMMRIMEA-- -M------K-NYK---VEL---YA---------WS------------------------- ------------------------------------KYYLPHQAV-------IRES-SLT TKL-RVVFDASAKTS-NK---KSLNDIMWVGPRVQ--KDIFDIIVNWR---KWEY--VVS SDIEKMYRQIKINHK--DQKFQY-----I------LWRDD---P-KT---------TV-K TYKLITVTYGTASAPYLATRV-LADV------------G----EN--CE-N--K-MIGEI I-KND--FYMDDL-MTGAN-S---IEDATTIVELIS-KE-LANS-------GFNLR-KWV SNNA-KI-LEMVENSGDNKIV------------------------------------SIR EDEFV-----------------KT--LG-------------------------------- -----LQWDPSKDEFKFTVCCS-------------------------------------- ----------------------------------------------------------NM SYPFLNTGIDYAGPYL-------------------------------------------- ----------------------------IRCS--KNRG---QKTF-----KG-YIA---V -FVCMA--TKAIHLEVVSDLTSDAF-----LAAFKRF-LARR-GKCANIYSDNGTNFVGA SRKLD-E-------ELEKAIRE-NS--------------------KIA---SQLQKERIQ ----WHFIPPASPHFGGIWEAGVKSMKYHLKRVIG--D-----NVL----TFEEM----- --STL-----LCQIEAVLNSRP--------LYS------------S-------------- ----------------------SE--------DV-------------------------- ----------- >24/1-543 ---ATKREFLSMVMSTFDPLGFLCCLMITAKLLLRE-VWRR-K----------I------ -SWDE-P-LPA--EMYNAFMDWRKEMEKVE---R-FRSP--RHY--F------------- -GSGLVK----TV-EMHV-FVDASQS-AFA-SVVYWR--ITYE-DG------DVQV-R-- FVCA---------------------------KTKC-APM--R-T---------------- --------------------------------MTIPRLELQAAV-LGT-RLMDTVRQD-- -H------S-VAI---AET---VL---------WT------------------------- -----------------------------------RTWYLPHFGV-------ENPN-K-P GKI-RLVFDAAAR-V-GG---VSLNSALSKGPQHY--KALASILFHFR---EGAV--GVC SDIKEMFHQVLIRPE--DRCAQR-----F------LWRDG---N-DQ---------RDPD VYEMCVMTFGAACSPSAAHHV-KTVN------------A----KRF-LDSD--P-RAVKA I-VDY--HYVDDY-VDSFA-T---ESEAIEVSSRVK-KI-HAEG-------GFELC-KFS SSSP-TV-ERML--GPSDHAQSIGWGEAE------------------------------- ----Q-----------------KI--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------AY GWPFKSTGLDYFGPLL-------------------------------------------- ----------------------------VT--VA-R-----H-QE-----KR-WVA---L -FTCLT--TRAIHLELAHDLSTDSC-----ILAIRNF-ICRR-GPVHRLRSDNGRNFVGA DREAK-R--------FAEIFEPER----------------------IQ---SELSSKGIE ----WIFNCPANPSEGGVWERMVQCVKRVLRHTVK--E-----VAP----KEHVL----- --ESF-----LIEAENVVNSRP--------LTH------------L-------------- ----------------------PV-------------SA--------------------- ----------- >240/1-566 ----TKRKVLSEIATLFDPLGLVGAVITKAKIIMQL-LWRL-Q----------D-ENNRQ LAWDA-K-LPA--KVEEEWVRFYQQLPILN---E-LRIA--RLV--T------------- --LT-K-PV--ST-QLHL-FSDASEK-AFG-VCAYLR--TQDE-KG------EVKV-A-- LLSS---------------------------RSRV-APL-------K------------- ---T----------------------------QSIPRLELCGAL-LAS-ELYLKIKAS-- -I-R----F-S-----GEC---FF---------WV------------------------- ------------------------------TVEENGRCYLPHHPV-------VKEE-STT TKV-RVVFDASAQTS-TG---FSLNDGLLAGPVIQ--DDLRSIILRSR---TRQI--ILV ADIEKMFRQIDVCPE--DCRLQS-----I------LWRSS---P-DK---------PL-A TYELSTVTYGTKPAPFLATRS-LSQL------------A----MDE-AEEF--P-LAAKA V-IED--FYMDDA-ITGAE-D---PNVAKQLRIQLQ-EL-LRRG-------GFVLR-KFA SNCE-AV-LEDLPIENRSIQTSDG-I-HLD---------------------------P-- -DSSV-----------------KT--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------TP TRPFATTGVDYFGPVY-------------------------------------------- ----------------------------VRTG--YRQR---A-V------KA-YVS---V -FVCFS--TKAVHLELVTDLSTARF-----LQALRRF-VSRR-GRCASLYSDNGTNFVGA KNQMM-E-------LINRLKSK-DH------------------HDVVA---KECAEDGMS ----WHFIPPGGPHFGGLWEAAVRSAKVHLLRVLG--D-----TVV----SYEDM----- --VTL-----LTQVECCLNSRP--------LTQ------------L-------------- ----------------------SD--------DPE--D-------L-------------- ----------- >241/1-550 ---PTKRQVLRCVMSLFDPLGLLSFFIIHGKVLIQD-LWRA-G----------T------ -EWDE-A-VGE--EVFDHWIRWTKMIEFVA---S-IRIP--RCY--F------------- -PRATEE-TYKAA-QLHV-FVDASEI-AYS-CTAYIR--TATR-DG------AFQC-A-- LVSA---------------------------KTKV-APL--K-P---------------- --------------------------------MSIPRLELQGCV-LGA-RLLKFVQDS-- -H------P-IAF---SKR---FL---------WT------------------------- ---------------T---------------ADPRRIWFLPLGAV-------TNPN-K-P GKV-RLVWDAAAK-V-SG---VSLNSVLLKGPDQL--TLLPAVLFRFR---LYSV--AVS ADIEQMFHQVGIRPG--DRNSLR-----F------LWSEN---S-DG---------P-VE IYIMDVATFGATCSPASAQYV-KNLN------------A----MEH-LQQY--P-RAVEG I-LKS--HYVDDY-LDSFG-S---ESEAKKISAEVR-LV-HHNG-------GFHLR-NWR SNSE-SV-TATL--GES----AKED-SKNLYL-----------------------E-SGE HV--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------MN VRPFSYVGLDYFGPLL-------------------------------------------- ----------------------------TK--VG-R-----S-NV-----KR-WIA---L -FTCLT--VRAVHLEIAYSLSTASC-----ISCVRRF-IGRR-GSPIEIFSDNGTNFQGA ERILR-E-Q----------IGK-E----------------------LS---MTFTNTTTK ----WSFIPPGAPHMGGAWERLVQSVKSAMKDA-Y--V---E-GKL----SDEEL----- --QTL-----VVEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >242/1-566 ----TRRIVASDTAKLFLPLGLLGPIVVLAKIFIQS-LWQT-T----------F------ -SWDE-P-LTQ--EQQHYWSEFRNSLEDIT---S-ISIP--RWV--A------------- --FAHN-PV--LT-ELHG-FCDASEK-AYG-ACLYLR--TVSS-DG------TISV-R-- LMAA---------------------------KSKV-APT--G-KSKK------------- ---QTT--------------------------LTLPRLELSSAL-LLA-HLYHKVSES-- -I-D----L---K---TKP---FF---------WT------------------------- ------------------------------SSPVGPAYYLPHHGV-------EKVD-STT TKL-RVVFDASCRTD-SG---ISLNQALMVGPVVQ--DDLFAIHLRFR---MHKI--AII ADIEKMYRQIRIHPS--DYQLQR-----I------LWRSS---S-SE---------PL-R TFELVTVTYGTASAPFLATRC-LKEL------------S----SQG-ANDY--P-LASLI L-GKD--FYVDDM-LTGVD-D---DEEGAELCSELL-EL-LQSA-------GFSLR-KWA SNSS-TF-LSKIPIELRDERS--S-F-ALD---------------------------S-- LSSPI-----------------KT--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------TP TLPFLNTGVDLCGPFQ-------------------------------------------- ----------------------------FRKL---PRA---PPV------KC-YVA---V -FVCLV--TKAAHVELVYDLSTAAF-----LAALHRF-VARR-GKPRLIECDNATNFKGA ARELA-Q-------LRKQFYDQ-QH------------------QAEII---ASCADDGTE ----FRFIPPRSPNFGGLWEAAVKSFKKHLRATIG--N-----SVL----SQDEF----- --VTL-----LARIEACLNSRP--------LTP------------L-------------- ----------------------SA--------DPN--D-------L-------------- ----------- >243/1-566 ---FTKRNVLSIVARLFDPLGLLGATITTAKVFMQR-LWTL-G----------N-EKDRK LDWDE-R-LPQ--TVGEEWRNYHEKLPLLN---T-IQVS--RCV--I------------- --PP-K-AR--SV-EFHC-FSDASMV-AYG-ATVYVR--SEEQ-DG------TVTV-H-- LLTS---------------------------KSKI-APL-------K------------- ---V----------------------------QSLPRLELCGAL-LSA-QLWEKVSNA-- -M-K----M-D-----VNI---HF---------WT------------------------- ------------------------------SDEAVKRIYLPHHPV-------IKES-STT TKV-RVVFDASCKTS-TG---ISLNDALFAGPIVQ--QDLRSIILRSR---FRQV--MVV SDVEKMFRQIWVNEH--DTPLQC-----I------LW-FG---P-DK---------DI-A TYELSTVTYGTKSAPFLATRT-LKQL------------A----EDE-RGRF--P-LAAKA I-DED--VYMDDV-ISGAD-D---VESAIDLRCQFN-DL-LLSG-------GFRLR-KWA SNRP-EV-LKDIPEENLALPTVEG-I-DWD---------------------------R-- -DAEV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV ARPFSKTGIDYFGPIY-------------------------------------------- ----------------------------IKAG--RRQA---A-I------KS-YVA---V -FVCMA--TKAVHLEHVSDLSTECF-----LQALRRF-FARR-GRCTDIYSDNGTNFVGA KNRML-E-------LCKLLQNQ-DH------------------REIVT---NECCSEGVQ ----WHFIPPGAPHFGGLWESAVRSTKYHLLRVLG--E-----NPV----SAEDF----- --RTL-----LAQVEGCLNSRP--------LTP------------I-------------- ----------------------TD--------DPT--D-------L-------------- ----------- >244/1-540 ---PTKQNVASRLAETFDPLGYTVPILVPFKRLMQN-CW-LDG----------M------ -RWKD-R-IPQ--KLLVDWQKVKEVLQDKT-----LTIP--RQL---------------- ---T-VRYDYESF-RLMV-FTDASKD-MMA-ATIYAH--YSY-KDA------PPVV-T-- LLAA---------------------------KNKI-KSAKNE-N---------------- --------------------------------WTIPKLELFAIE-IGT-NLAVNTVQE-- -I------R---IPI-TEV---CC---------FT------------------------- ---------------------------------------IPHRVV-------VKL-SSLT TKL-RIVYDASSHKK-NE---LSLNQCVHPGPPML--QSIFGILIRAR---LFKY--IVI ADIEKAFHQVQMQAQ--FRDLTR-----F------LWLKD---I-TK----PVTRENT-E TLHFRKIPFGLTSSPFLLAAT-IVYF------------L-------KRNPH--K-LN-EM T-QDN--IYVDNC-LYHTN-E---KSEIPGLVKSAK-DI-FNMM-------PMNLR-EFI VNDS-TE-MGKIPEKDR--A---------------------------------------- SALEV-----------------KV--LG-------------------------------- -----YLW---------------------------------------------------- ----------------------------------------------------------EP SIPFAHSGLDYMGPIP-------------------------------------------- ----------------------------YTKDDG-SPG------------KA-YVL---V -YTCLV--TRGARLELVPDGSTERY-----IESLGII-FSRS-GFPKSLYSDNAKTFQLG EKIIN-E-------DVTC----------GE-V-----------SESLT---SYLASHQID ----FVYITPLAPWQGGVYERIVKLVKNQLQKVLG--D-----NTL----DFHSL----- --RRV-----IAGAEAMINSRP--------LIA------------H-------------- ----------------------PK--------R------------L-------------- ----------- >245/1-542 ---PTKRAVLSCVMGFFDPLGLLAPFTVHGRIIVQH-LWRS-G----------C------ -EWDE-T-IDD--ACWEMWKRWTDLLPEVE---N-IRIP--RCY--L------------- -GGYSSL-EVESV-EAHI-FTDASEH-AYG-CVAFLR--VVVG-GT-------VLC-S-- VAMS---------------------------RSKV-APL--K-K---------------- --------------------------------QSVPRLELMAAV-LGA-RMSRTMTDT-- -H------S-LKI---DRS---VL---------WT------------------------- -------------------------------------WYLPLNVV-------VNPN-K-P GKI-RLVWDAAAT-V-QG---VSLNSQLLKGPDML--VPLVAVIVGFR---EHRV--AIG GDLREMYHQIKIVEK--DKQFQR-----F------LFRDD---P-KE---------N-PR VYVMDVATFGSTSSPCSAQYV-KNCN------------A----EEY-AEQF--P-KAATA I-IKH--HYVDDY-FDSVD-T---IEEAISRAKEVK-FV-HQKG-------GFEIR-NWV SNSV-EV-LHSL--GA-----QESISPVHFTE-----------------------D-KST LQ--E-----------------RV--LG-------------------------------- -----MFW---------------------------------------------------- ----------------------------------------------------------AY IRPFHSVGIDYLGPIE-------------------------------------------- ----------------------------VT--VG-R-----R-KE-----KR-WVA---V -FTCLA--VRAVHLELVASLSTQSC-----LMAIRRF-SCRR-GVPSEIFSDNATCFKGA NNEM------------QR-IHC-E----------------------CA---DELVSATTA ----WHFNPPATPHMGGIWERMVRSVKESMKA-LD--D---G-RTL----SDEVL----- --FTT-----IAEAEDMINARP--------LTY------------M----SQEA------ --------------------------------------A--------------------- ----------- >246/1-550 -----KAKVFSDILKVFDPLGFVAPVIVLAKVFMQK-LWAS-K----------M------ -DWAT-E-LNE--ELLCEWFEIRESLTALN---D-IRVP--RCV--V------------- --VP-N-TV--LH-ELHG-FADASTV-AYG-ANVYLR--CIRG-NG------SAEA-N-- LLCA---------------------------KSRV-APL-------K------------- ---K----------------------------LSVPNLELCAAL-LLA-RLVVKVIET-- -L-D----L-K-L---SAI---EL---------YS------------------------- ---------------------------------------LPHHAV-------LKPS-SSS TKL-RVVFDASAKA--GK---YSLNDVLKVGPTVQ--NDLFSIVLRFR---RHPV--AFT ADVVKMYRQVRVHPS--DTPYQR-----I------FWRKD---P-NE---------RL-R VLELNTVTYGTASAPFLATRC-LVEQ------------A----ESA-KGRF--P-AAAKI V-IED--MYVDDM-LSGAS-N---EKEAVKLVLEVK-KI-LEEG-------GFPVK-KWC SNSE-QV-LKCVPEEDREKPK------PIE---------------------------EYS ANEAI-----------------KA--LG-------------------------------- -----VLW---------------------------------------------------- ----------------------------------------------------------NV AAPFEYTGVDYAGPVT-------------------------------------------- ----------------------------VK--QGKYRP---KLT------KA-YIA---V -FVCLV--TKNIHLELVSDLTTEAF-----LAALDRF-VNRR-GMVRKIFSDNATNFVGA SRSLR-E-------MHELFKQD-LL------------------KRGIQ---DLLVPKAIE ----WSFIPPRAPNFGGLWEAGVKSVKTHLKRTLQ--N-----AVL----TFEEF----- --ATI-----LTHVEAVLNSRP--------LFS------------L-------------- ----------------------SD--------SPG--D-------P-------------- ----------- >247/1-569 -----KRQVVSDSSSLFDPLGFIGPVIVVAKMFVQE-LWRS-K----------R------ -SWDE-P-LED--ELQQNWLQFRCELAVIE---T-INVP--RWV--V------------- --PSID-PT--VI-ELHG-FCDASEK-AYG-TCIYIR--AVSP-SG------EISV-R-- LLTS---------------------------KSKL-APL--G-NSKK------------- ---QKK--------------------------ICLPRLELSSAL-LLS-HLFQKVQEA-- -L-K----L---Q---MKC---FF---------WT------------------------- -----------------------------------RPYYLPHHCI-------ERPD-SVT TKL-RVVFDASCVTD-TS---ISLNNALMVGPVVQ--GDLFSLILRWR---THRY--VII ADIEKMYRQIQIHPS--DQCLQR-----I------LWRED---P-SE---------PI-R IFELSTVTYGTSSAPYLATRC-LQEL------------S----KLG-RPSY--P-LAAEV V-GED--FYMDDL-MTGSN-D---IESGKQLCTQLQ-QL-LDSA-------GFPLR-KWS SNSP-EM-LSHIPETLRNERT--V-L-GLD---------------------------P-- -GASI-----------------KT--LG-------------------------------- ------KWEPASDSFGFH------------------------------------------ ----------------------------------------------------------TP TYPFLKTGVDLCGPLF-------------------------------------------- ----------------------------YRHY--GRKS---PPV------KC-YVA---I -FVCLV--TKAVHIELVADLTTDAF-----ISALKRF-IARR-SKPAVIECDNAKNFQGA SRALA-E-------LLTQFKSQ-QH------------------QHSVS---SFCVAEGID ----FKFIPPRSPNFGGLWEAAVKSFKKHLKATIG--T-----TVL----FKDDL----- --ETL-----LVQIESCLNSRP--------LTQ------------L-------------- ----------------------ST--------DPE--D-------L-------------- ----------- >248/1-565 ----TKRNVLSKIASIFDPHGWFGATVTTAKVFMQQ-LWT--P----------G-IDGKR LEWDQ-P-LPS--MMGENWRKFEEQLPVLS---S-VRFA--RCV--V------------- --IP-N-AT--SV-QLHC-FSDASTK-AYG-GCVYVR--SENA-KG------EVMV-R-- LLAS---------------------------KSRV-APL-------K------------- ---V----------------------------QTIPRLELCGAV-LVA-QLFKVLREA-- -L-D----I-P-----VDA---YF---------WT------------------------- ------------------------------DTGSAKRCYLPHHPV-------VREA-STT TKV-RVVFDASCKTS-SG---VSLNEVLLCGPVIQ--QDLRSIIYRCR---VKQI--MLV ADVEKMFRQIGICPE--DRLLQC-----V------LWRPT---P-TE---------AI-S TYELNTVTYGTKPAPFLATRT-LKQL------------A----MDE-KERF--P-LAAKV A-CED--IYMDDV-ITGTN-D---LDSAIDLRNQLD-KM-TVSC-------GFRLR-KWA CNRA-EV-LYGVEEDNLAIPCADG-I-NLD---------------------------R-- -DPSV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV ARPFSKTGVDYFGPVF-------------------------------------------- ----------------------------VRPG--PRRT---A-I------KA-YVC---L -FVCLC--TKAVHLELVSDLSTERF-----LQALHRF-TSRR-GPVAEIWSDNGTNFVGA RNRLH-E-------LFTLLRDK-QH------------------QEKVF---KDCANNEIR ----WSFSPPSGPHFGGLWEAAVRSAKHHILRVIG--D-----EPI----SIEDM----- --NTL-----LVQVEGCLNSRP--------ITP------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >249/1-540 ---PTKRELLKFMMGIFDPLCLLSPITIQLKLIFQE-LWRL-Q----------S------ -GWDD-E-IPD--GLVPRWIEWLNETARLG---E-IRLP--RYY--Y------------- -PAIQS---FGDV-ELHA-FCDASDK-AYA-CVVY----MVHRRKG------KSHV-A-- LVYA---------------------------KSRV-APL--K-S---------------- --------------------------------QTVPRLELQGCV-LAS-QMISVLQTE-- -M------M-VDI---TKV---YL---------WT------------------------- ----------------------------------PNTWYLPHFSV-------ATDE-K-- --F-RLVMDAKAK-S-HG---FSLNDLLLKGPDFV--PPLIAILIRAR---MKKI--AFV ADIREMFHQVLIRRE--DQDSQR-----F------LWRGM---NRTD----------PPN VYVMQVMIFGAVSSPSMAQFI-KNFN------------A----KEL-DEKY--P-GVERA V-VKQ--HYVDDY-FDCAD-T---EEAAIELVQRVI-EV-HDKG-------GFKLV-KFS SNSK-AV-LDSL--------------DAEIVA--------------------------EK QSD-V-----------------RV--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------PF VYPFTCTGIDYFGPLS-------------------------------------------- ----------------------------VK--VG-R-----R-VE-----KR-WVV---L -FTCMT--SRAVHLEVVPSLDTNSC-----IMAIRCF-MSVR-GLPQCIMTDNGTNFTGA DQEIK-T-------LVKTLDQP-Q----------------------IE---ESLSVRGVE ----WKFIPPGAPHFGGCWERLVRSVKTALRAMLH--D-----RHP----TDLVL----- --RTA-----LCEAMNTVNNRP--------LTH------------V-------------- -------------------TDDPL-------------DP--------------------- ----------- >25/1-574 ---YTKREVLGQIAKLFDPAGWLAPFVIQAKVFMQE-LWLQ-E----------L------ -GWDD-Q-LPS--ELHHRWQDFTKSYSFLD---Q-IRIP--RWV--L------------- -HDPNS-----DI-QFHC-FCDASQR-AYG-AAIYVR--VSND-QG------I-SC-C-- LLAA---------------------------KSRV-APV-------K------------- ---T----------------------------VSLPRLELCGAT-LLA-ELAAAVLPQ-- -L------P-VDN---AEA---FY---------WS------------------------- -------------------------------------FYLPHHAV-------FKPD-STT TKV-RVVFNASSKST-NG---VSLNDILYPGPVLQ--SDLTTQILKWR---FFRV--VFN ADITKMYRQIMVDPI--HTPFQR-----I------LFR-N---K-EG---------QL-G DYELNTVTFGINCAPFLAIRV-LQQL------------A----SDV-QSKF--P-LASDI I-KSY--MYVDDV-LAGAH-N---EATAIAMVNELQ-DA-LGSA-------GFPLR-KWT SNVK-SV-LSCIPKSHLLNAD----FLDIE------------------------------ EASTA-----------------KT--LG-------------------------------- -----IRWKATTDEFYFVISPQDVKSAYTKREVLGQIA---------------------- ----------------------------------------------------------TF ARPFTTTGIDFAGPFD-------------------------------------------- ----------------------------LKSF--TGRA---CRIS-----KG-YVC---V -FVCFS--TKAIHLEATSDLSTEAF-----LAAFARF-VSRR-GCPQQVQSDNGKNFVGA SRVLEKD-------FLRST------------------------QQKIL---SHYSHQNLS ----WHFIPPGAPHMGGLWEAGVKSFKTLFYKATS--N-----QKY----TFEEF----- --STL-----LAKVEACLNSRP--------ISP------------M-------------- ----------------------SE------------------------------------ ----------- >250/1-549 -----KRKVMSYIAQIWDPFGLVGPTTLKAKLFMQR-LWAL-K----------H--KGEA CAWDT-P-LPL--KIQLEWKEFHMLLHMLS---Q-VKVP--RFV--S------------- --TP-G-A---TI-QLHF-FSDASEK-AYG-ACCYVR--AAA--AN------GVTT-R-- LLSS---------------------------KSKV-ASL-------S------------- ---SH---------------------------DSINKLELNGGR-LST-QLYKKVKKA-- -L-N----L-SDA---VPV---FF---------WT------------------------- -----------------------------------------------------EHS-STT TKV-RVVFDASCKTS-SG---YSVNEKMLVGPVVQ--PDLLSTLLKFR---FQAV--ALV ADVEKMYRQVLVHPD--DRPLQR-----I------VWRFN---P-TD---------PI-S TYELRTVTYGTASAPFLATRT-LAQI------------A----QDN-KELH--P-DAAEA V-ARD--FYVDDL-ISGAP-D---VETAIKLRREIS-TM-LAAA-------GFPLK-KWA SNAP-EV-LRDIPPEDLALLP--V-Y-DLQ---------------------------D-- -GQTV-----------------TT--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------AP TRPFSVCGVDYCGPFY-------------------------------------------- ----------------------------IKSP--VRNR---APT------KV-YVA---I -FVCFS--TKAVHIELVSDLSTPAF-----IAALRRL-VARR-GQVVELNSDNATAFKGA ANALH-R-------VYQMLKVE-QVD-----------------RNEIF---TWCAENGIR ----WKFIPPRAPHFGGLWEAAVKSAKTHLLKTMG--T-----TSA----NYEDM----- --LTL-----LAQIEMCLNSRP--------LTP------------M-------------- ----------------------PD--------DPA--D-------A-------------- ----------- >251/1-569 ----TRRKLLSQLAKIFDPLGFFGPVITYAKLILRE-VGEL-H----------I------ -EWDD-P-VPT--DIGEKWRSFRIELTALR---E-VRLP--RWI--S------------- --WKGALKL-----ELHG-YADASDL-AYG-ACIYVK--GFFA-NE------ETEM-R-- LICS---------------------------KSRI-LPK--K-RKPK------------- ---EKA--------------------------ISTPRAELLAAL-LLA-RMVVKFLSA-- -TE-------LKF---ESV---HL---------WS------------------------- ------------------------------NEDPGSAFYLPHHCV-------LRPT-STT TKL-RVVFDGSAKTS-TG---VSINDVLRIGPTIQ--NDLTAILLRFR---GFQF--VFT LDIPKMFRQVRVHPE--DTRYQR-----I------FWRYD---R-ND---------FL-T VRELLTVTYGLGPSPFQATMA-LKQA------------A----ADH-EDEF--P-RAAEV V-DKG--TYMDDV-LTGAD-T---LAEACELQREMT-GL-LAKA-------CFGAH-KWC ANHS-DL-LREVPEELRGNSF------EVT---------------------------DDS SKTIV-----------------KT--LG-------------------------------- -----VTW---------------------------------------------------- ----------------------------------------------------------QP APVFSNTGVDYAGPFW-------------------------------------------- ----------------------------IKASSATRKP---QIT------KA-YVC---L -FVCLQ--TRAIHLELVSDLTTDAF-----LASLRRF-ASRR-GCPKTMHSDNGTNFVGA KTELH-E-------LWQMFQNE-CA------------------TKKIT---SYCVEKGIE ----WSFIPPRSPHFGGIWEAGVKQVKHHLKRIVG--E-----RKL----SYEEL----- --YTT-----LTQIEAVLNSRP--------LVP------------S-------------- ----------------------SD--------DPS--D-------Y-------------- ----------- >252/1-562 ---PTKRNILSTIMRVYDPLGLISNITIQGKIFMQE-LWKL-G----------L------ -EWDE-S-IPE--DLNESWNHWLTRLLATK---N-IKFP--RCY--S------------- -TMT-NI---KRR-ELHV-FADASDK-AYA-AVVYLR--TVSQ-NSDDPKSEQIEV-N-- LLAA---------------------------KARV-APN--K-M---------------- --------------------------------LSIPRLELLAAV-LGT-RIAENIMNE-- -L------R-LKI---DRT---IY---------WS------------------------- ---------------I---------------TKSSRTYYIPHFSV-------INPN-KQP PKP-RLVFDAAAK-T-RG---ESLNSNLLSGPDTN--ANLLGVLMRFR---EGRY--AIS GDIQEMFHQVKIRKE--DQDAQR-----F------LFRE----S-DS---------SEID TYVMQVMTFGATCSPACAQFV-KNQN------------A----LKL-HENY--P-REVDA I-LNN--HYVDDY-LDSFD-L---LEEAKEVVNNVI-MI-HGKA-------HYNIR-NFV SNSN-SL-LNSI--------EESKRMEINA-I-----------------------KLGDD EQLYE-----------------KV--LG-------------------------------- -----IFWNTETDTINFKVKEL-------------------------------------- ----------------------------------------------------------PF VKPFTYAGVDYFGPVN-------------------------------------------- ----------------------------VS--IG-R-----R-VE-----KR-WGV---V -FTCLI--TRAVYLDLSRNLSTDAF-----FICLKNV-QSRR-GRIMQLYSDNGTNFIGA NNEIK-R-------IRQRL-----------------------------------ASEGIE ----WFFNPPSAPHFGGVWERMVKEVKSILASV----Q---E-TMP-----EDVL----- --RGL-----LTEIEYIINSRP--------LTH------------I-------------- ----------------------PL-------------ES--------------------- ----------- >256/1-526 ----TKRGVLKKLAGLYDPLGWASPYVVRAKVMLQR-TWSR-G----------I------ -DWDE-L-LPS--DLRLEWSKWEAEMVALK---S-FVVP--RYI--Y------------- ----RQPSRLRKK-QLVV-FCDASEE-ACA-AVAYVR--ATST-VG------EVTC-H-- LVIA---------------------------KTRL-MPL--K-P---------------- --------------------------------ISIPRGELMACQ-LAV-RLAKAACVQ-- -L------S-LSM---REV---IY---------LS------------------------- ---------------E---------------QWL-----LPHHPV-------LSPH-K-- -PLPRVVFDSAAV-H-DG---ICLNDCLEAGPSLH--NDLPGVLMRFR---ERPV--ALA GDVSDMFCHVRLRTE--DRKYHR-----Y------LWRDL---E-TD---------KPPD VYEMNCLVFGDKSSPCEANFA-VQRT------------A----EDN-KEQW--PDAA-AV V-KRD--IFVDDL-YTSCE-D---VGEAVKLREDVT-AL-MAEG-------GFPMR-KWM SSSA-EV----------------------------------------------------- --------------------------LA-------------------------------- -----TVP---------------------------------------------------- ----------------------------------------------------------GV STPFKHVGLDYAGPFQ-------------------------------------------- ----------------------------VR--VG-R-----NRVE-----KR-YVC---L -FTCLH--MRAVHLETAHSLDTDSF-----IMALRRF-RARR-GNPVRIMSDNGSNFVGA ERELR-D-------ALQELSQE-R----------------------IA---DELSVHGVK ----WDFNPPDGPWFGGAWEALVKSTKRTMRVMLG--N-----VLT----VDEVF----- --RTV-----LAEAESILNSRP--------LVY--------------------------- ----------------GGSVSSPT-------------DV--------------------- ----------- >257/1-539 ----TKRKMLAVINRIYDLLGLASPVTVIGKVLYSK-VCLS-E----------K------ -RWDE-A-ITD-VEIVREWNKWLKSMKACP---S-VSIP--RSV--V------------- ----DQH--VTRI-ELHG-FSDASKT-AVS-AAIYVV--AHHA-DS------SVRQ-T-- LLVA---------------------------KSRV-APK--N------------------ --------------------------------QSIPRLELVGAH-TLT-KLMTHVKEV-- -L------QGQPI---QIY---QC---------WV------------------------- -------------------------------------HYIAHTMV-------TRD-DAQT SKL-RIVYDCSARED-DN--TPSLNDCLEVGPPLQ--PMLFDILLRNR---MNRL--CLT GDIQKAFLQIKVDTK--DRDCMR-----L------FWYDN---L---KD------RNI-V EYRFARVIFGSGPSPYILGAT-LQKH------------V----ASYSDKYP--E-TV-YQ L-LTN--TYVDDV-QTGGD-D---PEQLLRFKQEAS-EI-MESG-------GFQLH-KWH SNVL-EA-EESTSAERADRAV--------------------------------------- D-------RPPV----------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------EF SEPFDVTGVDFAGPIY-------------------------------------------- ----------------------------YRT-----KS---EQG------KA-YIA---L -FTCAA--TRAVHLKLCPDLSAPNF-----QRALKEF-VARR-GCPQMIVSDNGKTFVAT GKWLS-V-------LKKD--------------------------ESLS---NYLASQAII ----WRFNMSRAPWWGGFFERLVGVMKNALSKAVG--R-----SLL----NYCEL----- --EDA-----LLDVETVMNNRP--------LVY------------Q-------------- ----------------------GE--------EF-------------------P------ ----------- >258/1-507 ----TKRNTLKVMASMYDPLGIVSPIMVSMKVLFQE-LC-VEK----------L------ -DWDE-E-LTG--ERKKRWLSWLDDLKRVK---E-VRIA--RCV--Y------------- --GVSGAEV--TY-SLHG-FGDASKK-AYC-AVIYC---VTEL-YG------AYHV-E-- LLTS---------------------------KTRV-APL--K-E---------------- --------------------------------QTIPRLELMSGR-VLA-QLMATVVNA-- -ISG----E-VEL---SGR---RC---------WL------------------------- --------------------------------------------------------EAKT TKV-RIVYDASSKER-KR--GVCLNDCLHVGPALT--PLLYEILIRFR---QRKI--ALV GDIEKAFLNIEVDEA--DRDCLR-----F------LWVND---V-EAKE------AAP-I IYRFCRVVFGVNCSPFLLNAT-LRYH------------L----ESFAKEEP--E-FV-RV M-KDS--FYVDDL-VTGAE-S---ADKALELFEKAR-AR-MATG-------GFKLR-KWL SNDE-KV-TAEI------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SK APPFSKTGVDFAGPVY-------------------------------------------- ----------------------------IKS--H--EG----MK------KM-YIA---L -FTCSV--TRALHLELTEDLSTRSF-----LNCLRRF-CARR-GTPALIVSDNAKTFKSA AKFLN-E-------LYDQ--------------------------PDIR---TYCEENRIQ ----WRFNRERAPWWGGFFERIIGTVKRCLKKVLG--N-----ARL----NCDEM----- --QTT-----LVELEGTLNSRP--------LTY--------------------------- ---------------------------------E-------------------Y------ ----------- >259/1-564 ---PTKREALSFVMSAYDPLGLISHITIQGRILMQS-INAA-T----------N------ -DWDT-Q-IPD--SLHGKWIEWLKMITSVK---D-LAIP--RPI--V------------- -ASI--M---NPV-EIHT-FVDASQE-AFA-AAVYAR--SNFN-GC-------FVV-R-- LVAA---------------------------KSRV-APT--K-A---------------- --------------------------------LSIPKLELQAAV-LGA-RLTASVIKE-- -L------R-LKI---SRT---IF---------WS------------------------- -----------------------------------KIFYIPHFVV-------VNKN-KPI PKP-RLVFDAAAK-V-NG---VSLNSLLLTGPDEM--ASLFGVLLRFR---EGPI--CVC GDIKEMFHQVKIRKE--DQDAQR-----I------LWRDG---D-ST---------RTPD TYVMQVMTFGATCSPACAQVV-KNRN------------A----EAN-SEMY--P-LALEP I-RNQ--HYVDDY-LDSFF-S---MEKAIKTVTEVI-QV-HENG-------GFHIR-NFI SNKR-EL-MEAI--------PQERHQVKAI-V-----------------------DIKEK DSCVE-----------------KI--LG-------------------------------- -----VQWNTQLDCFGYKV----------------------------------------- ----------------------------------------------------------PY NPPFLHTGVDYFGPLD-------------------------------------------- ----------------------------VT--VK-R-----S-TE-----KR-WGA---I -FTCMS--TRAVHLELAEKLDTDSF-----MVCLNNF-LHRR-GKITHLYSDNGTNFVGA EKELK-K-------IVEDIDLR-M----------------------GR---EAALKYKIE ----WKFNPPAAPHFGGSWERLIQNIKKALRHMVT--EWK-T-RHP----TPETL----- --RAT-----LIQIESILNSRP--------LTH------------L-------------- ----------------------PL-------------TSEEE------------------ ----------- >26/1-553 ---ATKRNILSVTSKLFDPLGLLSPIVIKGKILLQE-LWLN-K----------L------ -DWDE-S-IPM--HLETAWDMLKSTLSQLD---E-ISIP--RFV--H------------- --TD-P-LS--PV-QLHA-FADASMR-AYG-ACVYIR--SKTA-EG------FKL--S-- LLTS---------------------------KSKV-APL-------K------------- ---T----------------------------KTLPRLELCAAH-LLA-DLCHRIKPL-- -L-K----V-P-I---ERI---VY---------WS------------------------- ------------------------------KIPSTPHYVIPHQCV-------LRPQ-STS TKL-RVVFDASCKTS-SQ---VALNDILMVGPTIQ--EELYSTLLRFR---LHRY--ALT ADVKKMYRQVMVNEA--DRKFQL-----I------VWRRD---P-SE---------SL-R LYKLNTVTYGTGPAPFLAIRC-LKRL------------S----ESA-KCSF--P-RAADV I-GSD--FYVDDM-LTGAA-C---VEELKTIKSEVS-QV-LQTA-------GFELT-KWF SNSP-EV-TASESSVQSIPIS--------------------------------------- DSEST-----------------KA--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------RA LRPFAICGVDFCGPVY-------------------------------------------- ----------------------------TTLK--IRGR---PPY------KS-YVA---L -FVCFA--SKAVHLEIVSDLSTDSF-----LLAFQRF-IGRR-GCPQTVHCDNATNFVGA SRHFL-A-------LRDRIEEQ-A--------------------DAIR---EFASKSGCE ----FAFTPPRAPHMGGLWEAGVKTAKHLLLRAVG--S-----ALL----NAEEL----- --ATV-----LVGIEATMNSRP--------LGA------------L-------------- ----------------------SQ--------DPS--D-------G-------------- ----------- >262/1-523 ---ATKRSVLSELAQVFDPLGFLSPLLILGKIFVQE-LWLL-K----------Q------ -DWDE-E-LPA--SYATQWLRYREELKLID---K-FSIP--RSS--I------------- -PITAD-LG--TL-QLFG-FSDASNR-AYG-GVIYAR--VRDE-GG------GISV-R-- LVTA---------------------------KSKV-APV-------R------------- ---V----------------------------TSLPRLELQGAL-LVA-KLMAKVCAC-- -L-H----I-P-V---EKV---NY---------FT------------------------- --------------------------------------FMPHHPV-------IRPE-SLT TKL-RVVFDASCRSS-NG---RSLNDATLVGPTLQ--PDLFETLTRFR---FYRY--ALT ADIKKMYRQILVAEP--HRNYQC-----I------LWRCN---V-SD---------PI-Q VLRLNTVTYGTNSAPFLAVRC-LYYL------------V----DRY-AEKF--P-LAREA V-KRS--FYMDDM-LCGAE-S---KEELTKLKEQVT-EL-LGLG-------KFELH-KWR SNY--------------------------------------------------------- --------------------------QG-------------------------------- -----MDN---------------------------------------------------- ----------------------------------------------------------GN IYPFERAGLDFAGPIW-------------------------------------------- ----------------------------MHFH--MRGK---RPV------KV-YLC---I -FVCFA--TKACHIEIVSDLSSNAF-----IAALKRF-FARR-GLSSDLYCDNATNFVGA SRELN-------------RAFD-SPS-----------------QKLID---DECSQRGVR ----FHFIPPRSPHFGGLWESAVKVAKQLLVKCTN--S-----TAL----NYEDL----- --ATA-----ITQVEAVMNSRP--------LHP------------L-------------- ----------------------SS--------DPN--D-------F-------------- ----------- >263/1-559 ---PTKREVLKTLMAIYDPMGLIANFLIYLKILLQE-IWRS-G----------C------ -GWDD-E-IDG--KLSERWITWIEALPNVR---Q-VSIP--RCY--R------------- -IGTSAE-QTNNV-ELHI-FCDASEN-GMA-AVAYFR--FKE--GE------KVEC-A-- LIGS---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRLELQAAV-LGA-RLADCIVKA-- -H------R-MKI---TRR---VF---------WT------------------------- -----------------------------------NDWYLPIFPV-------TNPN-K-P GKL-RIVFDAAAK-V-HG---VSLNSFLLTGPDQL--VSLLTVLYKFR---EFRV--AIV GDIREMFFQVQMKKQ--DQRSQM-----I------LWDDG---N-PG---------NDPE VYAVAVMTFGAACSPSCAHYV-KNQN------------A----ERF-EKQH--P-RAVEC I-KYE--HYVDDM-LASVE-T---EEEAIKLATEVR-SI-HCQG-------GFEIR-NWL SNSS-NV-VESL--HE---NTAT---EKNMSF-----------------------CTE-M ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY QRPFSYTGIDYFGPMS-------------------------------------------- ----------------------------VL--VG-R-----R-TE-----KR-WGV---L -LTCMT--TRGVHIEIAHSLTTDSC-----ILALRNF-IARR-GSPLQIISDRGTNFIGA SRELR-E-------ALQHVDEK-K----------------------LM---VEFVSPNTK ----WTFNPPAAPHYGGCWERLIQSVKKTLNDFDP------P-RLP----SDEIL----- --RSM-----LMEIEMILNSRS--------LTD------------I-------------- ----------------------PL-------------DNDTENTLTPNHF---------- ----------- >264/1-546 ---PTKREILRTMMTIYDPLGLISHYLMYLKVLLQE-IWRT-G----------V------ -GWDE-K-VTQ--ESYDKWQTWLKLLPEIE---L-LQIP--RCY--R------------- -LQTSTD-KYTEI-QLHT-FVDASEN-GMA-AVVYLR--FAE--AG------TVEC-S-- LVTA---------------------------KTRV-APL--K-Y---------------- --------------------------------LTIPRLELQAAL-IGA-RLAHSVIQA-- -L------D-ITV---ARC---VF---------WS------------------------- -------------------------------------WYLPTFPV-------INPN-K-P GKI-RIVWDAAAT-T-NG---VSLNSALLAGPDLL--EPLIHVLYRFR---QYRF--AIC GDICEMFHQVVIRNE--DQHSQR-----F------FLRDD---E-GQ---------KEPS TYVMQVMTFGASCSPATAQFV-KNMN------------A----DRF-SNTH--P-SAARA I-VRC--TYVDDM-LSSAE-T---EQEAIELAKSVW-FI-HNEG-------GFEIR-NWM SNSS-TV-LAAI--RG---NSNV---EKSLDL-----------------------TST-L AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF IRPFTHTGVDYFGPME-------------------------------------------- ----------------------------VC--IG-R-----R-VE-----KR-WGV---L -LTCLS--IRAVHIELASSLTTNSC-----IMALRNF-IARR-GTPAVFYSDRGTNFIGS ERELK-Q-------TLKTVDQN-R----------------------MA---QEFVSSNTS ----WSFNPPAAPHMGGSWERLVQSVKRTLSELKP------C-PRP----NDEEL----- --RNA-----LIEVEGILNARP--------LTH------------V-------------- ----------------------PI-------------ED--------------------- ----------- >265/1-556 ---PTKREVLRCVMSLYDPLGLLAMFVIHGKILIQD-LWRT-G----------T------ -QWDE-E-IND--MQLRHWRRWIDLLPAIA---D-LRIP--RSY--F------------- -AAASKK-MYENG-EWHL-FVDASQH-AYA-CVLYLR--IFDD-AG------EPQC-T-- LIGG---------------------------KAKV-APL--K-P---------------- --------------------------------LTIPKLELQACV-LGA-RFLRYTQEH-- -H------P-INV---RRR---VL---------WS------------------------- -------------------------------------WYLPIGVV-------TNPN-K-P GKV-RLIWDAAAK-A-HG---TSLNDMLLKGPDEL--SSLLGVLFRFR---LYAV--AAC ADVKEMFLQIMIRKE--DKHAQR-----F------LWRYE---P-TD---------E-LE TYIVDVVMFGSACSPATAQYV-KNRN------------A----REH-MEQF--P-RAVEG I-IES--TYVDDF-LDSFE-T---EEEACQVSHDVR-EI-FRNG-------GFELR-NWT SNSM-EL-MRCL--G------EANGDIKCLSS-----------------------MGDEA ----E-----------------RV--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------PF VRPFSYVGLDYFGPVL-------------------------------------------- ----------------------------VK--RG-R-----S-NE-----KR-WIA---L -FTCLT--VRAIHLEVVHSLSTESC-----VLAVRRF-VARR-GAPVEIFSDNGTNFLGA SRQLR-R-E------IEE-RNE-T----------------------LA---AIFTNAHTR ----WTFNPPGAPHMGGVWERMVRSVKAAISTVME--A---K-HAP----DDETF----- --ETV-----ILDAEAMINSRP--------LTY------------V-------------- ----------------------PL-------------DPENQEAITPNHF---------- ----------- >266/1-565 ----TKRLALSYIAKIFDPLGLLSPTIIIAKLFMQQ-LWKL-Q----------E--NGKP WDWDR-E-LPS--HLQKEWTAFHSKLHSLR---E-VRIP--RYT--S------------- --IR-Q-AT--NV-QLHI-FADASQV-AYG-ACCYVR--AEN--DS------TTSV-Q-- LLAA---------------------------KSKV-VSL-------S------------- ---NT---------------------------HSIARLELCAAR-LAT-QLFRKVSQS-- -L-N----G-E-----YDA---FA---------WT------------------------- ---------------------------------------LPHHAV-------LKES-STT TKV-RVVFDASCKTA-SG---YSLNDKLLVGPVIQ--DDLFTIIVRFR---SHAV--ALS ADVEKMYRQILHDSR--DTEYLR-----I------RYRRN---T-AE---------PI-Q TFQLQTVTYGTSCAPFLATRT-LKQI------------A----LDH-KMQY--P-RAVDP V-LHD--FYVDDL-LTGTD-E---LADAIEMQRQIS-EM-LKQA-------GFVLK-KWV SNVP-EA-LIGIPSEDLAILP--T-H-EWQ---------------------------D-- -PQFV-----------------ST--LG-------------------------------- -----LVWEPAVDMLRYRI----------------------------------------- ----------------------------------------------------------TP TRPFQVIGVDYCGPVL-------------------------------------------- ----------------------------LKSP--VRNR---SPT------KA-YIA---I -FVCFA--TRAVHIELVNDLTTAAF-----LAALRRF-VARR-GKIAELHSDNATTFKGA AHELH-R-------LYEMFKCS-NSE-----------------RIEFF---NWCANNEIQ ----WKFIPPRAPHFGGLWEAAVRSAKQHLIRTIG--S-----TSL----TQEGL----- --VTL-----LAQVEQCPNSRP--------LIP------------L-------------- ----------------------SS--------SPE------------------------- ----------- >267/1-547 ---PTKREVLKCVMSLFDPLGLLANFTIHGRILIQD-LWRA-G----------T------ -GWDE-A-ISP--SQMRDWRRWVDVFPLIA---Q-LRIP--RCY--F------------- -PEAREK-VYENA-ELHL-FVDASQL-AYA-CVLYLR--VVDS-EG------EPHC-T-- MLCG---------------------------KAKV-APL--K-P---------------- --------------------------------LTIPKMELQACL-LGA-RLLKSTEQH-- -H------P-ISV---KKR---VL---------WT------------------------- -------------------------------------WYLPLGVV-------TNPK-K-P GKV-RIIWDAAAK-V-QG---TSLNDMLLKGPDEL--ISLPGVLFRFR---MYGI--AVC ADVKEMFLQIRMRDE--DKHAQR-----F------LWRED---P-AD---------D-IA TYFVDVVTFGSACSPATAQYV-KNRN------------A----KEH-AEKY--P-RAVRG I-LTS--TYVDDY-LDSFG-T---FEEASRVSREVR-GI-FSNG-------GFVLR-NWV SNNP-VV-LERL--GGE----SSSPGMKSLTS-----------------------TADDG ----E-----------------RV--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------AF VRPFTFVGLDYFGPLL-------------------------------------------- ----------------------------VR--RG-R-----A-QE-----KR-WVA---L -FTCLT--IRAIHLEVVSSLSTDSC-----ILAVRRF-VARR-GAPVEVFSDNGTNFVGA SQQLR-K-E------IDE-RND-A----------------------LA---ATFTNANTR ----WTFNPPGAPHMGGVWERMVRSVKAAMSTMTE--L---Q-RTP----DDETL----- --LTV-----IVEAEGMINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >268/1-557 ---MTKRLILSYIAKIFDPLGLLGPTIIIAKMFMQQ-LWAL-K----------I--HGKA YDWDS-E-LPS--HLQHEWSKFHSTLSSLR---N-LTVP--RYI--S------------- --QC-T-AT--SL-QIHI-FADASQL-AYG-ACCYIR--AES--ME------GVTV-Q-- LLTA---------------------------KSKV-VAL-------S------------- ---NS---------------------------HSIARLELCAAR-LAT-LLYEKVQQS-- -L-K----I-S-----ATT---IC---------WT------------------------- ---------------------------------------LPHHAV-------IKES-STT TKV-RVVFDASCKTS-SG---YSLNDKLLVGPVVQ--EDLLSIILRFR---SRAI--ALT ADVEKMYRQILHSPH--DRNYLR-----I------RYREH---P-AD---------PI-S TFELQTVTYGTASAPFLATRT-LKQI------------A----LDH-KEEY--P-LAMNA V-MND--FYVDDL-LTGTD-D---LSEAIVIQRQIS-DM-LNSA-------GFTLK-KWA SNRS-EA-LKNVPSEDVAVQL--S-H-EWK---------------------------S-- -SKQV-----------------ST--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------TP TRPFSVCGVDYCGPIY-------------------------------------------- ----------------------------IKQT--IRNR---SPI------KA-YIA---I -FVCFS--TRAVHIELVGDLTSTAF-----INALRRL-IARR-GQISELHSDNATTFKGA AHELN-R-------VYKMLKSD-EHD-----------------RAAIF---DWCAMNHMK ----WKFIPPRAPHFGGLWEAAVKAAKKHIVRTIG--T-----TSI----TQESM----- --LTL-----LAQVEQCLNSRP--------ITP------------L-------------- ----------------------SD--------EPS--D-------L-------------- ----------- >269/1-552 ---PTKRIILSSVMALFDPLGLLAPFTTLGKMLIQD-LWRT-G----------C------ -DWDQ-A-VDE--ESFKKWKSWIGLLPEIS---K-LKIP--RSY--F------------- -GTVQSK-DFGPV-QLHV-FCDAGES-AFG-CAGFLR--IEIN-GE-------IKC-S-- LVMA---------------------------RSKV-APL--K-Q---------------- --------------------------------LTIPRLELEAAV-LGS-RLSHTIKKN-- -L------S-LQI---NQT---FF---------WT------------------------- ---------------G---------------ADNSKVWYLPLNVV-------LNPR-K-P NKV-RLVWDAAAT-V-AG---VSLNTKLLKGPDLL--TSLPAVISKFR---ERPI--AIG GDIREMYHQVHIRDA--DKQAQR-----F------LFRFD---Y-TQ---------P-PT VYIMDVATFGATCSPCSAQFI-KNLN------------A----MEY-SSQF--P-DAASA I-VDR--TYVDDY-FDSLD-S---EEEALRRAKEVR-FI-NSKA-------GFEVR-NWT SNSS-LV-LSGI--GE-----ENSNGLVHFHL-----------------------D-KAT DN--E-----------------RV--LG-------------------------------- -----VIW---------------------------------------------------- ----------------------------------------------------------PY KRPFTFVGIDYLGPVE-------------------------------------------- ----------------------------VS--VG-R-----R-SE-----KR-WIV---L -FTCLV--VRAIHLEVAYNLTAQSC-----IMAIRRF-ICRR-GPAAEYFSDNGTNLKAA SKEFV-H-Q------LQV-IRN-E----------------------CA---EEFTSARTK ----WHFNPPAAPHMGGIWERMVRTVKNVMTV-LN--D---G-RRL----TDEIL----- --HTS-----LAETEDMVNSRP--------LVY------------A----PQES------ ------------------------------------------------------------ ----------- >27/1-553 -----KRIVLSTLAKIYDPLGWLSPVTLVGKLFIQK-LWLA-D----------K------ -NWDE-E-LSE--QDTREWNSFKNSLTELE---S-IRIP--RWL--N------------- --SQHN-----KSMQIHG-FADASEK-AYA-AVVYAK--V------------DSST-I-- IIAS---------------------------KSKV-NPK-------K------------- ---NR---------------------------KTIPKLELCAAH-LLA-KLIQRVKVA-- -V------G-S-N---VEC---YA---------WS------------------------- --------------------------------------YLPHQGV-------IRDS-SLT TKL-RVVFDADAKTT-SN---KSLNDIMWVGPRVQ--KDIFDIMVKWR---KWPF--VIS ADIEKMYRQINVDKD--DQQYLH-----I------IWRDN---P-NE---------KL-K DYKLTTVTYGTASAPYLATRV-LVAI------------A----DN--CK-N--Q-AIREI I-KND--FYMDDL-MTGAD-T---ILDAKKHVKEVT-RE-FNKV-------GFNLR-KWI TNIP-EI-IEGIRDDQENKVL------------------------------------TIE ENESV-----------------KT--LG-------------------------------- -----LQWEPVKD----------------------------------------------- ----------------------------------------------------------TM SHPFTNTGVDFAGPYH-------------------------------------------- ----------------------------IRCS--KNRG---QKSY-----KG-YIA---V -FVCMA--TKAIHLEVVSDLTSDAF-----LAALRRF-FSRR-GKCAKIFSDNGTNFVGA SRKLD-E-------EYQKALKD-NI--------------------KVV---PILEREQIE ----WHFIPPAGPHFGGIWEAGVKSVKYHLKRVIG--D-----NNL----TYEEM----- --STL-----LTQFEPVLNSRP--------LYT------------R-------------- ----------------------SG--------DID--D-------L-VLTRSHY------ ----------- >270/1-547 ---QTRRGILSVTSAVYDPLGYVAPVLLPAKHILQE-LCKR-N----------Y------ -GWDE-E-VPQ--TLKQQWIKWLTDLKEIS---E-FRVS--RCL--K------------- -PHDFGT--PVHA-QLHH-FADASER-GYG-TVTYLR--LQNK-AG------HIHI-S-- FLLG---------------------------KSRV-TPL--K-P---------------- --------------------------------VTIPRLELTAAV-LAV-RVDRMVKSE-- -L------Q-LSL---SES---CF---------WT------------------------- ---------------R---------------CGEDNLFYIPHHGV-------YHPR-K-- GKL-RVVFDCGAK-F-KG---TSLNEQLLQGPNLT--SSLIGVFLRFR---QEPV--AFM SDVKSMFYQVRVADE--DKDFLR-----F------LWWPN---GDLH---------KQVE EYRMTVHLFGAVSSPSCACYA-LRKT------------A----EDS-RNGF--SEEVIDT V-YKN--FYVDDC-LKSSP-S---VQKAVQIVQDLT-EL-CQKG-------GFHLT-QWI SSSR-KV-LETI-------PEKEHSKSVSELN-----------------------LD--- ------------------------------------------------------------ ------------------------------------------------I----------- ----------------------------------------------------------PD FPPFTNVGVDYFGPIE-------------------------------------------- ----------------------------VK--QG-R-----S-YV-----KR-YGV---I -FTCMA--SRAIHLEVAHSLDTDSC-----ISAIRRF-ICRR-GPVAHFRSDNGTNFTGA EKELK-R-------AIADLNHR-S----------------------IE---KALIHDNIK ----WTFNPPAASHHGGAWESMIRLVRKVLVSVLH--L---Q--TL----TDETL----- --VTV-----LCEAEAILNDRP--------ITR------------V-------------- ----------------------SE-------------D--------PNDL---------- ----------- >271/1-575 ----TKRNILSNIMRIYDPLGLVINLTTESKVLMQE-LWKE-K----------V------ -DWDD-V-LPI--NLQRKWQEWLDAIKTVE---D-IKIV--RSY--S------------- -NIK-GN---CRR-ELHT-FVDASER-AFA-AVVYLK--TIQG-DT-------VNV-N-- ILAA---------------------------KSRV-APT--K-P---------------- --------------------------------LTIPKLELQGAI-LGV-RLADTIKKE-- -L------R-LNI---DEE---FY---------WT------------------------- -----------------------------------KINYIPHFAI-------VNKN-KFP PKP-RLVFDAAAK-N-EG---RSLNSFLLSGPDAT--TSLFGVLIRFR---EHEI--ACS GDIKEMFHQVKVMQE--DQCAQR-----F------LYRE----S-PN---------KDPQ VYVMQVMTFGATCSPACAQFV-KNQN------------A----LKF-EKQN--P-KAVKA I-TDN--HYVDDY-LDSFA-S---IEDAAKTVNEIM-TI-HDKA-------NFFIR-NFV SNSH-EL-ISSL--------PENRRANKEM-H-----------------------FIENK DDTYE-----------------KI--LG-------------------------------- -----MHWDTRNDTFRYKLKIPPLEDKKLTKRNILSNIMRIYDPLGLVI----------- ----------------------------------------------------------AF QKPFTHTGVDYFGPLN-------------------------------------------- ----------------------------VT--IG-R-----R-VE-----KR-WGV---L -FTCLT--TRATHLDIANDLSANTF-----IMCLRAM-QHRR-GKITDIYSDNGTNFVGA HNQLK-K-------LIERC-----------------------------------AIEGIR ----WHFNPPGGPHFGGSWERLVREVKSLLP-T----N---K-NFP-----EATL----- --RAI-----FMEIEFIINNRP--------LTH------------I-------------- ----------------------PI-------------EN--------------------- ----------- >272/1-559 ----TKRIALSQIARLFDPLGLVGPVITMAKLFMQE-LWEL-K----------T-DDGQI WGWDR-E-LPS--EYTQRWHEYTSKLPLLN---E-LRID--RYI--F------------- --CP-N-STQGSI-QLHF-FSDASEK-AYG-SCCYIR--STNS-TG------VTKI-A-- LLTA---------------------------RSRV-APL-------K------------- ---QH---------------------------QSIPRLELCGAL-LSA-ELYEKVTAS-- -L-K----I-A-----AET---YF---------WV------------------------- ------------------------------------------------------ED-STT TKV-RVVFDASCRTI-EG---SSLNDALMVGPIVQ--QDLRSIIMRSR---THPI--MLI ADIKQMFRQIRVDER--DTPLQR-----I------VWRSS---P-DA---------PM-N TYELKTVTYGTACAPFLATRV-LRQL------------A----DDE-QTQF--P-KATQV L-RED--FYVDDL-FSGAD-T---VEETIELRRQLD-SL-LSAG-------GFELR-KWA SNVD-AV-LEEVLEDNRALKT--S-V-DLD---------------------------R-- -DQCI-----------------KS--LG-------------------------------- -----LHWEPATDHLRYKI----------------------------------------- ----------------------------------------------------------TA TRPFTITGIDYWGPIP-------------------------------------------- ----------------------------LKPF--HRRA---APG------KA-YVA---V -FVCFS--TKAVHLELVGDLSTAKF-----IQALRRF-VARR-GLCAEIFSDNGRNFLGA ANELK-Q-------I---VQSN-QH------------------LQSIA---EECATNGIR ----WRFNPPKASHFGGLWEAAIHSAQKHFFRVLG--S-----HTL----PMEDT----- --QTL-----LAQIECCLNSRP--------LVP------------L-------------- ----------------------SD--------DAS--D-------F-------------- ----------- >273/1-595 ---PTKRQALSIVMSPFDPLGFLSFFLIHGKILIQD-VWRA-K----------T------ -LWDQ-T-IPE--KLWERWLQWTEYFQRLD---Q-ISIP--RCY--F------------- -PRHSVQ-DFISL-QLHV-FVDASED-AFA-CVAYFR--AEFK-DD-------IEV-A-- LVAG---------------------------KSKV-APL--K-A---------------- --------------------------------LSIPRLELMAAV-IGA-RLKKTIINE-- -H------S-LRI---DQA---II---------WS------------------------- ---------------E---------------ADPRRVWYLPLGVA-------LNPK-K-P SKV-RIFCDAAAK-V-DG---LSLNAMLLKGPDLL--NTLFGVLFGFR---EKRI--AIC ADLMEMFHQIQIRKE--DRHAQR-----L------LWRED---P-TK---------T-PE VYLMDVATFGATCSPCSAQFV-KNTN------------A----TEH-AKEY--P-AAADA I-HRK--HYVDDY-LDSAD-N---VEEAIKIAEEVR-HV-HSLG-------GFHLR-NWL SNSK-EV-LTRV--GE-NGQA----TEKNLQM-----------------------D-EGS SA--E-----------------RV--LG-------------------------------- -----LFWRPEPDDFTFSTELVKHVEQPTKRQALSIVMSPFDPLGFLSFFL--------- ----------------------------------------------------------AF ERPFSYIGVDYFGPIA-------------------------------------------- ----------------------------VR--VN-R-----T-SA-----KR-WVA---L -FTCLT--IRAVHLEIVHSLSAESC-----KMAFRRF-VARR-GSPVEVYSDRGTNFVGS SNELQ-Q-E------MNA-IDQ-Q----------------------LA---ETFTNAHTK ----WIFNPPAAPHFGGAWERLVRSVKTALSA-MY--T---S-RVP----NEETL----- --ATL-----VAEAEGVVNSRP--------LTF------------I-------------- ----------------------PL-------------EE--------------------- ----------- >274/1-552 ---PTKRQVLRVVMSIFDPLGLVAPFVVHGKCLIQD-IWRA-G----------V------ -DWDE-R-IPR--ELLIQWRRWVEVLHHLN---Q-VQVP--RCY--F------------- -PGYDSH-SFRSL-ELHV-FVDASEA-AYA-CAAYFR--IVD--LG------QVRC-A-- LVSA---------------------------KTKV-APL--K-P---------------- --------------------------------MSIPRLELQAAV-IGV-RLMKSVQEN-- -H------T-LPI---NRR---VI---------WG------------------------- ---------------S---------------SDPRKVWYLPLGVV-------QNPN-K-P GKI-RVVWDAAAK-A-SG---VSLNSMLLKGPDLL--TSLPSVLFRFR---QREV--GIT GDIKEMFHQILIQPE--DRQAQR-----F------LWRNH---P-ED---------T-VE EYVMDVATFGATCSPCSAQYV-KNKN------------A----EEW-KDVY--P-EAAAA I-VEN--TYVDDY-ANSSD-T---VEEAVRIALEVK-QI-HASA-------GFEIR-NWL SNSK-QV-LRRV--GG-QGSV----TSKCFAV-----------------------E-KLT DS--E-----------------RV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PY VRPFTFIGIDYCGPFL-------------------------------------------- ----------------------------IR--IG-R-----N-NV-----KR-WVV---L -ITCLT--VRAVHLEVASSMSSESC-----KLAIRRF-IARR-GAPQEIYSDNGTNFVGV SKELR-A-E------SVT-VNR-T----------------------LA---ETFTNRDTQ ----WRFNPPAAPHMGGVWERLVRSVKSSLET-LS--V---S-RTP----DEETF----- --RTL-----LIEVEGIVNSRP--------LTF------------V-------------- ----------------------PL-------------ES--------------------- ----------- >275/1-572 ---PTKRSILSAISRLFDPLGLIAPVVVKSKILMQE-LWLL-S----------C------ -GWDD-P-VSA--QVQQKWENIRHDLPNIS---S-YRVD--RYA--L------------- --LP-N-AT---V-QLHI-FSDASES-AYG-ACIYAR--CEDM-KG------QIRI-C-- LLAS---------------------------KSRV-APL-------K------------- ---R----------------------------VSLPRLELCAAV-LGA-HLYDRIKKA-- -I-S----I-E-V---FAT---FF---------WT------------------------- ------------------------------EAEPPVAYYLPHHPV-------FKDS-STT TKV-RVVFDASAKTS-TG---YSLNEALSVGPVVQ--DDLLDIMLRFR---TFKV--AVV GDIAKMYRQVLLHPD--DRSLVR-----I------FFRFS---Q-SS---------PV-Q IYELLTVTYGLAPSSYLATRT-LQQL------------A----DDE-GHAY--P-LGGPA L-RKS--FYVDDF-IGGAQ-S---VEEAIRLRTEMS-EL-LTKG-------GFELR-KWT SNEL-EV-LKGLKDDQIGTQS--S-L-EFS---------------------------P-- -NETV-----------------KA--LG-------------------------------- -----ICWEPESDTLRFDS----------------------------I------------ ----------------------------------------------------------TP SRPFSIVGVDYAGPFY-------------------------------------------- ----------------------------LKAI--HKRA---SPT------KA-YLC---L -FVCFA--TKAVHLELVSELSTSAF-----LATLRRF-ISRR-GRPSDIHSDNGKNFEGA KNDIA-E-------LFALLSNN-ES------------------QAEIV---SSCASEGIT ----WHLTPPKAPHFGGLWESAIKVAKKHLYRQIG--S-----SRL----SYEDM----- --STV-----LAQIEAVMNSRP--------LLP------------S-------------- ----------------------SE--------DPN--D-------L-------------- ----------- >276/1-527 ----TMRSIYSILASQYDPLGYIIPYTTRAKILVQR-LWDK-K----------R------ -DWDD-PQLPE--DLLSLWNSWEKELCELD---K-ITLP--RCY--S------------- -SPDMDV-PTSRR-DVHV-FCDASEK-AYG-SVAYLR--TEST-EG------QVEV-A-- FLAA---------------------------RSRV-APR--K-Q---------------- --------------------------------QSIPRLELCAAL-SGA-QLSKVLVTE-- -L------T-LPI---CSL---TL---------WS------------------------- ---------------A---------------EKSQESWYIPHHMV-------THN----- GKN-RVVYNCSFQ-Y-EG---QNLNKLLLPGPTLS--PTLLAVLLRFR---EHST--ALS SDIRGMFHQVRLLPE--DKSLLR-----F------LW-RD---IAVD---------QAPE VYEWQVLPFGTTCSPCCATFA-LQKH------------V----QDH-SQP---GDQVREV I-EKS--FYVDNC-LYSLP-S---KDGAKDLVDQLC-AL-LNEG-------GFELR-QWA SNCP-TV-VAHL------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KLL ----------------------------------------------------------LF KPAFFSTGMDCFGPYL-------------------------------------------- ----------------------------IK--IG-R-----R-NE-----KR-WGI---I -FKCLT--TRAVYIDLLASIDSDSF-----LMALRRF-IARR-GKPYELLSDQGTNFKGG ERELK-E-------SLGALHSE------------------------LQ---SHLASQQIK ----FVFNPPGAPHFGGCWEREIRSIKAALQVTLG--A---Q--TV----TEEVL----- --RTV-----LTEIEGILNSKP--------LSY------------T-------------- ----------------------SS-------------DI--------------------- ----------- >277/1-540 ---CTRRGILSTVSSVYDPMGFLAPLMLPAKLLLQE-MCRQ-N----------L------ -GWDE-E-IPP--ALRKQWTCWISNLDEVS---E-FQVG--RCL--K------------- -PTDFGE--IMHA-CLHH-FSDASEK-GYG-MVTYLR--MINS-DD------KVHV-T-- FLLA---------------------------KSRV-APL--K-T---------------- --------------------------------LTIPRLELTAAV-LSV-KVDQMLRRE-- -L------R-LQL---ENS---VF---------WT------------------------- ---------------D---------------RDDGKVWYIPHHGV-------LHAK-K-- GTL-RVVFDCGAT-F-RD---TSLNKQLLQGPNLT--NSLLGVLLRFR---QETI--ALM ADIQAMFHQVKVAED--DVDFLR-----F------LWWSD---GNLK---------QEVT TYRMIVHLFGAASSPSCACYA-LRRT------------A----EDN-QALF--PSEVIDT V-FDC--FYVDDC-LKSIF-S---EEAAIAMVQDLI-AL-CQKG-------GFCLT-KWT SNSR-KV-LQSV-------PEEYRSK------------------------------D--- ------------------------------------------------------------ ------------------------------------------------I----------- ----------------------------------------------------------PD LPPFTNTGVDYFGPIE-------------------------------------------- ----------------------------VR--RG-R-----S-TV-----KR-YGV---I -FTCMA--SRAVHLEVAYSLDTDGC-----INALRRF-ISRR-GQVVHIRSDNGTNFIGA NRELK-E-------AISAWNDK-Q----------------------IE---KELLQVGVQ ----WSFNPPAGSHYGGAWERIIRMVRNILCSVLR--Q---Q--TL----DDESF----- --HTI-----LCEVESILNDRP--------ITK------------V-------------- ----------------------SS-------------D--------PNDL---------- ----------- >278/1-601 ---MTRRGILSIVNSIYDPLGFLAPVILHAKLLLKD-LCKE-Q----------R------ -GWDE-N-IDG--KHAEDWERWMKDVTHLS---N-FHVS--RCV--K------------- -PTKFGC--TITA-QLHH-FSDASEY-AYG-IVSYLL--LENE-RG------EKHC-T-- FLLG---------------------------KSRV-APL--K-R---------------- --------------------------------VTIPRLELTAAV-VAL-KVDKMLHQE-- -I------Q-VPL---QQS---VF---------WT------------------------- ---------------N---------------RDDNRVFYIPHHGV-------YHPK-K-- RKL-RVVFDCTSS-Y-QG---KCLNSELLQGPDLT--NSLIGVLLRFR---EEPV--AVM ADIESMFYQVKVPEH--DADLLR-----F------LWWPN---GRLD---------EPVE EFRMTVHLFGATSSPSVASYA-LRRT------------A----EDH-KDAA--SPDAVQT V-LRN--FYVDDC-LRSVT-T---ENVAVNLVSDLR-AL-CSSG-------GFTLT-KWM SNSR-NV-LLSI-------PEEHRASEVKDLD-----------------------LRRDA -LPVE-----------------RT--LG-------------------------------- -----VQWDTENDTFTFSIKLQDRPMTRRGILSIVNSIYDPLGFLAPVI----------- ----------------------------------------------------------PH QPPFTNTGVDFFGPFE-------------------------------------------- ----------------------------VK--RG-R-----V-TL-----KR-YGV---M -FTCLT--LRAVHIEVADSLDTDSC-----INAIRRF-ICRR-GQVTIMRSDNGTNFVAA ERELR-E-------AIQQLDNY-K----------------------IE---RALQPKGIK ----WIFNSPAASHQGGIWERQIRTARRILNSLLK--E---Q--TV----NDDCL----- --QTI-----MCEVESIINGRP--------LTS------------V-------------- ----------------------SD-------------D--------ANDV---------- ----------- >28/1-602 ---PTKREFLSLVMSTFDPIGFLSCYMVTAKLLMRE-IWRK-G----------V------ -NWDE-P-LPA--DLAAAFEDWRQEMRKIE---E-FRCP--RYY--F------------- -GGGRVR----ML-QLHI-FVDSSQS-AFA-AAAYWR--ATYE-NG------DVQA-H-- FISS---------------------------KTKC-APM--R-T---------------- --------------------------------MSIPRLELQAAV-LGT-RLMDTVKQE-- -H------G-VAI---SSC---VL---------WT------------------------- ---------------------------------EGKLWYLPHFGV-------ENPN-K-P GKI-RLVFDAAAK-V-NG---VSLNSALLKGPQRY--KPLPAVLFHFR---EGAV--GVC ADIKEMFHQVLMQPQ--DRGSQR-----F------LWRNG---D-DQ---------REPD TYEMQVMTFGAACSPCSADYVQKTLN------------A----SQY-SSTD--P-RAALA I-KEY--HYVDDY-VDSFT-S---EEEAIAVSTRVR-EI-HADA-------GFDLC-RFT SSSA-SV-VRAL--NPLESIASVRWTEAE------------------------------- ----E-----------------KV--LG-------------------------------- -----MYWQPATDDFKFG-KYHRVPR-VMTGERVPTKREFLGLVM--------------- ------------------------------------------------MGPLPEDRLEAN GWPFKFTGLDYFGPLF-------------------------------------------- ----------------------------VT--VG-R-----R-TE-----KR-WVA---L -FTCLT--TRAIHLEMAHDLSTDSC-----IIAMRNF-MCRR-GPVVRIRSDNGKNFVGA DREAR-R--------FSEVFEPAQ----------------------IQ---GELSSKGVE ----WIFNCPANPAEGGAWERMVQCVKKVLAHTMK--E-----LAP----KEHVL----- --ENL-----LIEAESIVNSRP--------LTH------------L-------------- ----------------------PV-------------TVDQEAPLTPNDL---------- ----------- >280/1-556 ---PTKRQVLRVVMSLFDPLGLISYFVIHGKILMQE-IWAS-G----------V------ -NWDE-P-IGS--ELCEQWQRWTDLLPQLN---S-VRIP--RCY--F------------- -PTANYQ-TYSSL-QVHV-FVDASKS-AYA-SVVYFR--VES--RG------GIAV-T-- LVAG---------------------------KAKV-APL--K-M---------------- --------------------------------MSIPRLELQAAV-LGT-RLLNSVIAM-- -H------K-LPV---SRR---VL---------WT------------------------- -------------------------------------WYLPLGVV-------LNPK-K-P NKV-RIIWDAAAK-V-NG---ISLNSALLKGPDYL--ASLIEVFYHFR---LYAV--ALT GDIKEMFHRLLIRQE--DRQFQR-----F------LWRDR---D-SD---------E-VN VYVMDVAIFGATCSPSSAQYV-KNVN------------A----LEF-ESES--S-RAVTA I-VRY--HYVDDY-LDSFP-T---AEEAVKVGTDVR-RI-HAAG-------GFEIR-NFL SNDP-AV-AVSV--GK-----KSTSMEKMINP-----------------------E-KN- NV--E-----------------SV--LG-------------------------------- -----MKWIPIGDNLTYTF----------------------------------------- ----------------------------------------------------------PF VRPFTFVGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NA-----KR-WIA---L -FTCLS--IRAVHMEVVHSLSTESC-----IQAVRRF-VSRR-GSPAEIFSDNGTSFHGA NNQLQ-K-E------IKD-RNA-A----------------------LA---SVFTNSNTR ----WSFNPPGTPHMGGVWERMVRSVKEAIKSTLE--S---S-RKP----DDETL----- --ETV-----IIEAESMINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >282/1-550 ---PTKRQVLRTVMSLFDPLGLVAHFVVHGKLIMQR-IWRE-G----------L------ -DWDE-Q-ISG--EILEDWCKWSRLLTKLN---E-VTVP--RCF--F------------- -SG-NGR-AHNDA-QIHM-FVDASEN-AYA-CVAYLR--SYG--NG------PPQC-T-- LIAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAL-IGS-RLLETICKA-- -L------T-IPI---TTR---YL---------WT------------------------- ---------------T---------------TEPGRVWYLPLGVV-------RNPR-K-P EKV-RLIWDAAAR-A-KG---ISFNDMVLKGPDLL--TALPVVLLRFR---QKSV--AFS GDIKEMFHQFRIRKE--DRQAQR-----F------LYREN---P-GK---------P-PQ IFVMDVATFGAACSPCIAQYL-KNKN------------A----EDY-KEQY--P-EAARA I-IEN--HYVDDF-LDSVD-T---VDEAVELIEDVK-YV-HAQA-------GMEIR-NFA SNSS-EV-LERI--GE-ASRT----QQKSINL-----------------------E-AN- -M--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PF IRPFTHTGVDYFGPIF-------------------------------------------- ----------------------------VK--QG-R-----S-MV-----KR-WIA---L -FTCLS--IRAVHLEVVHSLSTQSC-----VLAIRRF-VARR-GSPATFCSDNGTNFVGA SNILK-E-Q------IRT-IGK-S----------------------CA---ATFTNTDTK ----WLFNPPLAPHMGGPWERMVRSVKVAMSAIAD--H---P-RHP----SDEVL----- --ETI-----VLEAEAIVNSRP--------LTY------------V-------------- ----------------------PL-------------EH--------------------- ----------- >284/1-545 ---PTKRELLSLVMSIFDPLGLVANYVIHGKVLIQD-VWRT-N----------T------ -GWDE-K-IPD--EIFPSWQRWVVSLRELA---Q-LRID--RCY--F------------- -PGYTPA-ALETL-ELHV-FVDASLA-AYA-AVAYFR--IDD--RG------TIRC-S-- LVSS---------------------------KTKV-APL--K-Q---------------- --------------------------------LSVPRLELQAAV-LGT-RLMKSIIGG-- -H------T-LPI---RRK---VF---------WS------------------------- -------------------------------------WYLPLGVV-------SNPK-K-P EKV-RIVWDAAAS-V-RG---VSLNSVLLKGPDLL--QSLPTVLCRFR---QREV--AIN ADIREMFHQVYIQPE--DRQAQR-----F------LWRNN---P-TE---------R-ME VFVMDVAIFGATCSPCSAQFA-KNLN------------A----KEH-AAEY--P-SAATA I-VEN--HYVDDY-LDSVD-T---IEQAIQLATEVK-LV-HLRG-------GFDLR-HWL SNRK-EV-LEKL--GD-ECSD----ESKNFVM-----------------------G-KGC SS--E-----------------RI--LG-------------------------------- -----MIW---------------------------------------------------- ----------------------------------------------------------PY IKPFTYTGLDYFGPLT-------------------------------------------- ----------------------------VR--IG-R-----S-QT-----KR-WVA---L -FTCLT--TRAVHLELAFTLSTESC-----KLAIRRF-VARR-GPPAEIFSDQGTNFQGA RKELK-E-Q------IQR-MNS-E----------------------LS---TTFTNTTTK ----WKLNPPYAPHMGGIWERLVRSVKSGLAA-ME--I---S-RSA----DEETL----- --LTA-----LAEVESMVNTRP--------LTY------------L-------------- ----------------------PL-------------DA--------------------- ----------- >285/1-557 ---PTKRQVLRLVMSLFDPYGFIAHFVVHGKILMQH-IWRS-G----------T------ -EWDE-E-ISP--ELYKMWQDWIRLLERLR---E-VEVP--RCF--F------------- -GTTGSS-IRANI-QLHV-FVDASEQ-AYA-CAAYLR--IVQ--NG------VVHC-A-- LVAA---------------------------KTKV-APV--K-P---------------- --------------------------------LSIPRLELQACI-IGC-RLMETINAA-- -L------N-LNV---EER---FF---------WT------------------------- -------------------------------------WFLPLGVV-------TNPK-K-P EKV-RLIWDAASR-V-HG---ISFNDTLLKGPDML--TSLFAVLLRFR---QRSV--AVC GDIREMFHQIRIISQ--DKQYQR-----F------LFRER---Q-DE---------T-PQ IYVMDVATFGATCSPCSSQFV-KNKN------------A----REF-ETKY--P-RAAEA I-IKA--HYVDDY-LDSVD-S---VEEAVQLVKEVK-HV-HSQG-------GFEIR-NFI SNSP-DV-LHQL--GE-QNSL----QKKSLDL-----------------------D-GSG KV--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PH IRAFSYTGVDYFGPIF-------------------------------------------- ----------------------------VK--QG-R-----S-LV-----KR-WAA---L -FTCLT--IRAVHMEIVYSLSTQSC-----VMAIRRF-VSRR-GSPAAFYSDNGTCFRGA NNLLC-E-Q------IQA-LHQ-D----------------------CA---VTFTNAKTS ----WHFNPPSAPHMGGCWERMVRSVKTAMAAIAD--H---P-HHP----SDEVL----- --ETV-----LLEAEAIINSRP--------LTY------------V-------------- ----------------------PL-------------DDADQEVLTPNHF---------- ----------- >286/1-540 ----TKRKILSTIATLFDPTGLIGAVIVEAKIFMQR-LWTI-E----------G-EDGQR LDWDQ-P-VPP--KVGEEWCKFYEHLPRLQ---E-VEVH--RCV--I------------- --IP-A-AV--IV-EVHC-FSDASMK-AYG-ACIYLR--SQDS-SG------NILV-R-- LLAS---------------------------RSKV-APL-------K------------- ---T----------------------------QSLPRLELCGAL-LGT-QLCQKVREA-- -I-R----F-K-----GEI---FF---------WT------------------------- ------------------------------ASEGSKRCYLPHHPV-------VKEA-STT TKV-RVVFDASCRTS-NG---ISLNDALYAGPVIQ--EDLRAIIIRGR---TRQI--MVV ADVEKMFRQIWIRPE--DRHLQC-----I------LWRSS---P-ME---------DV-R TYELNTVTYGTKPAPFLATRT-LQQL------------A----TDE-GRRF--P-SAAVA V-RED--TYMDDV-ITGAD-N---VEDATRLRCELQ-DM-MEAG-------GFHLR-KWA SNCS-KV-LEGVPV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TV SRPFSRVGVDYFGPVY-------------------------------------------- ----------------------------VRLG--PRRT---A-V------KA-YVA---L -FVCFC--TKAIHMELVTDLSTERF-----LQALRRF-ISRR-GKPSDIFSDNGTNFVGA RNQLT-E-------LMASLKNR-DC------------------HEKIS---KECNAEGIQ ----WHFSPPSGPHFGGLWEAAVRSAKKHLLKVLG--E-----NVL----TFEDM----- --NTL-----IVQIESCLNSRP--------LTQ------------L-------------- ----------------------TE--------DPE--D-------L-------------- ----------- >288/1-551 ---PTKRQVLKCVMSLFDPLGLLACVLVHGKIMMQD-IWRS-A----------I------ -KWDE-C-IDD--QINERWVKWIELLKDVN---E-VRVP--RCY--F------------- -NEASAA-LYDSL-EAHI-FVDASEV-AYA-ALVYFR--VIRS-DE------TATC-A-- LVSA---------------------------KTKV-APL--K-Y---------------- --------------------------------VSIPRLELMAAV-LGV-RLLSFVKES-- -H------T-VQI---QRC---VY---------WS------------------------- ---------------N---------------ADPRRTWYLPLGAV-------CNPK-K-P GKV-RLIWDAAAK-V-DG---ISLNSVLLPGPDLL--TSLPSVQFRFR---QYPV--AVS GDIKEMFHQVQIIER--DRPAQS-----F------LFREN---P-VD---------K-PS VFMMDVLTFGATSSPSSAQFI-KNRN------------A----QDF-SERY--P-RASEA I-RKC--HYVDDY-LDSFE-S---TDEAKSVASEVR-WI-HSKG-------GFELR-NWA SNQK-AV-LEYL--GEH----PKLS-TKDLAM-----------------------K---A DS--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------PG IRPFSYVGIDYFGPIL-------------------------------------------- ----------------------------VK--IG-R-----A-TA-----KR-WIC---L -ITCLT--IRAVHVEVAYDLSTKSC-----IACIRRF-VCRR-GAPIEIYSDNGRNFTGA DRVLR-E-Q------IRR-LEE-E----------------------AA---TTFTSTATK ----WLFIPPSAPHMGGSWERMVRSVKNALTSM-P--Q---E-DKL----DDEGL----- --QTM-----IVEAEAIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >289/1-536 ---WTKRIVLSEISKLFDPAGFLGPIVTTCKLVMQD-IWRQ-G----------L------ -PWDE-L-LPD--ELSYRWRLIREQMPAIN---E-MKKQ--RCL--I------------- --SK-D-AV--SI-QLHG-FSDASMR-AYG-GVLYIR--SVDR-DG------TISV-N-- LVAS---------------------------KSRV-APF-------K------------- ---M----------------------------QTIPKLEMCGAK-LLA-ELTQKVVSS-- -M-Q----V-P-F---DDV---IL---------HC------------------------- ---------------------------------------IPHHAV-------YKMS-SST TKT-RVVFDASAKTT-SG---LSLNDTLSVGPTVQ--NDLLSIILKFC---THQV--VLT ADIPKMYRQVRLHTE--DCKYQR-----I------LWLDD---D-SK----------L-K VYELQTVTYGVASSPHHATRA-LVQL------------A----SDE-GKDF--P-LASKV I-IED--SYIDDF-LTGGS-S---TAEVIQIYTELT-QL-LHRG-------GFGVH-KFC SNSA-EV-LQAIPVELHEKQV------HFE---------------------------DAD I----------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------NP SPPFSKVGIDYAGPFM-------------------------------------------- ----------------------------LK--TGGRGS---RLA------KA-YVV---V -FVCMA--VKAIHFELVSNLSTDNF-----IAALQRF-SSRR-GLPTDIHSDNGTCFVGA NHELA-A-------LRDLFNDQ-QH------------------QRKLD---EFCSLKGIR ----WHFIPPRSPHFGGIWEAGVKSMKHHMKRVVG--E-----TKL----TYEEM----- --ITF-----LAQTEAILNSRP--------LCP------------M-------------- ----------------------SE------------------------------------ ----------- >29/1-537 ---CTKRQVLSDTARIFDPLGILAPVVIKFKILLQE-LWLL-N----------L------ -DWDS-E-LPT--KQAHLWQTFRKDIFTLR---N-LKIP--RFV--D------------- --NQPD-----DI-ELHG-FSDASLK-AYS-AVIYNR--VTHL-DG------SIGV-A-- LIAA---------------------------KTRV-SPL-------K------------- ---Q----------------------------KSLPRLELCGAL-LLA-RLFQAVRSG-- -L-R----Q-K-D---VKI---HA---------WT------------------------- ---------------------------------------LPHHPV-------I------G AKL-RVVFDGSFQDR-DG---RSLNDALHIGPCIQ--RNLFNVCLRFR---MHRF--VFS ADIVKMFRQILVAPE--HQNFQR-----I------LWRED---P-EE---------PL-K HYKLTTVTYGTACAPFLAVRV-LEQL------------A----TDH-EYEF--P-RAARI L-LDD--FYVDDV-LTGAM-N---EQELLDIKEELI-LL-MSRA-------QLELS-KWV SNSK-RI-ASNEGNEI------DFSK---------------------------------- --MAA-----------------KV--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------RQ AFPFEHTGCDYAGPIL-------------------------------------------- ----------------------------LKVH--KGRN---PRKE-----KG-YIC---L -FVCMV--TSALHLELATDLSTDTF-----LAALKRF-MARR-GKCSQMYSDNGRNFVGA KRALD-E-------MVQLLASR-EH------------------NDVVS---KALADQGIK ----WNFIPPYSPHWGGKWESAVRSVKLHLRRVIG--T-----NVL----TFEQM----- --HTL-----LSQIESVVNSRP--------LCT------------A-------------- ----------------------SD--------TE-----------I-------------- ----------- >290/1-560 ---PTLRNVYKVLATQYDPLGYLIPFTTKAKILIQD-LWNL-K----------V------ -GWDD-VIHPE--SLRIQWRQWEAELANLH---T-VEIP--RAY--I------------- -PPCADT-EGMQR-TIHI-FCDASER-AYG-SVAYLC--TLDQ-HN------QTHV-A-- FVMA---------------------------RSRV-APR--K-Q---------------- --------------------------------ISMPRLELCGAL-TGA-QLAKLLSKE-- -L------S-IPA---RDV---VL---------WT------------------------- -----------------------------------ESWYLPHHLV-------HHN----- NKA-RLVFNCSYQ-Y-RG---LALNEHLLPGPILG--PSLLGVLLRFR---EHTV--AIS GDIKAMFHQIRLLPE--DRSLLR-----F------LW-RD---MKKN---------EEPN VFEWQVLPFGTTCSPCCATYA-LQRH------------V----KDN-CVG---YEDVQMS V-EQA--FYVDNC-LQSLN-C---PEKARSLIDRMR-SH-LSSG-------GFEIR-QWA SNIP-QV-IEHL-------PIEARAASTELWV-----------------------SEHSS -DPQE-----------------PA--LG-------------------------------- -----LRWNCLTDHLGYQH----------------------------------------- ----------------------------------------------------------LY KPPFWSTGVDCFGPFT-------------------------------------------- ----------------------------IK--IG-R-----R-TE-----KR-WGI---I -FKCMT--TSCIHLDLLESMDTDAF-----LMALRRF-VSRR-GKPFEILADRGTNFRGG ATELQ-E-------AFTALEAS------------------------LK---EQLAGQEIT ----FQFNPPHAPHFGGTWEREIRSVKTALQVVLG--N---R--TV----TESVL----- --RTV-----LVEVEGIINSKP--------LGY------------V-------------- ----------------------SS-------------DV--------------------- ----------- >291/1-550 ---FTRRGVLSTVNSVFDPLGLLAPVTIQGRALLRE-LTSE-S----------A------ -DWDT-S-LPE--VKLNKWVAWRSSLQELE---K-LHVS--RTY--T------------- -KTSLTE--AVHT-ELCV-FSDASTK-AIG-AVAYLK--VLQK-DG------QVEV-G-- FVMG---------------------------KAKL-APL--S-E---------------- --------------------------------PTIPRLELCAAV-LAV-EMADLIKDE-- -L------D-LEL---NDI---KF---------FT------------------------- -------------------------------------WYLPTFGV-------YHPQ-K-P NQI-RVVFDSSAC-Y-SG---VSLNDVLLTGPDLN--NSLVGVLLRFR---KERV--AIL ADIQQMFHCFLVRDD--HRNFLR-----F------LWYKD---NDVN---------KEII EYRMNVHVFGNRPSPAVAIYG-LRRA------------I----REG-AKDH--GEDTIKF V-ERH--FYVDDG-VVSVP-S---EAEAIDLLQRTQ-AS-LAES-------NLRLH-KFA SNSQ-IV-MKAF-------PPEDCAPVIKDLD-----------------------LSGET -SPTQ-----------------RS--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------KI CPPFTYVGLDVFGPWS-------------------------------------------- ----------------------------VT--TR-RTRGGQA-ES-----KR-WAI---M -FGCMS--SRAVHIEVIESMDASSC-----INALRRF-FALR-GPAKQLRSDCGTNFVGA CKELG-M-------DK-------M----------------------VQ---RYLSEQGCN ----WEFNPPHSSHMGGSWERLIGIARRILDSMFL--QL--K-ARL----THEVL----- --CTL-----LAEVTAIINARP--------L--------------L-------------- ----------------------PV-------------SA--------------------- ----------- >292/1-599 -----RRGILSVVNSIYDPLGFLAPLILPVKLLLRD-LCKQ-G----------Y------ -GWDD-E-IDD--KRADQWVKWLEDLSQIS---N-VKFK--RCL--K------------- -PEKFGI--TAEA-QLHH-FSDASES-AYG-TATYLV--LTNE-QN------QKYC-S-- LLMG---------------------------KSRV-SPL--K-Q---------------- --------------------------------ITIPRLELTAAT-IAV-KMDKILRQE-- -L------Q-MPL---QPS---IF---------WT------------------------- ---------------N---------------RNDNKVWYIPHHGV-------YHPK-K-- NKI-RVVFDCTAS-F-QG---MSLNSQLLQGPNLT--NTLIGVLTRFR---EEPI--AVM ADVESMFYQVKVPEE--DTDLLR-----F------LWWPD---GNLN---------APIE EYRMTVHLFGATSSPSCASYA-LRKT------------A----EDR-KHVA--SQKAVDT V-LNN--FYVDDC-LKSVS-N---EQEAINLVKEIQ-DL-CLEG-------GFRLT-KWV SNNR-KV-LLSI-------PEDQRASGVKDLD-----------------------LDQDS -LPIE-----------------RA--LG-------------------------------- -----MQWCTDDDTFTYHIKVQEKPSSRRGILSVVNSIYDPLGFLAPLI----------- ----------------------------------------------------------PD KPPFTNVGVDYFGPFE-------------------------------------------- ----------------------------VK--RG-R-----S-TV-----KR-YGV---L -FTCLT--IRAVHIEVADSLDTDSC-----INALRRF-ISRR-GQVAVMRSDNGTNFVGA ERELR-E-------ALKNLNHI-T----------------------IE---QAMLQKNIN ----WIFNSPAASHQGGVWERQIRTVRRILNALLK--E---Q--SI----SDDSL----- --HTI-----MCEVESIINNRP--------ITT------------T-------------- ----------------------SE-------------D--------PNDL---------- ----------- >294/1-548 ---PTKREVLRTLMAIYDPLGLIANFLIYLKILLQE-IWRS-G----------C------ -GWDD-E-ISG--KIADRWSTWIEALPNVR---Q-VRIP--RCY--R------------- -HETSAK-PTNNV-ELHI-FCDASEN-GIA-AVAYFR--FEE--KQ------IVEC-A-- LVGS---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRLELQAAV-IGA-RLADCIVKS-- -H------R-LKI---TQR---VF---------WT------------------------- -----------------------------------NDWYLPIFPV-------TNPN-K-P GKL-RIVFDAAAK-V-NG---VSLNSFLLTGPDQL--VSLLAVLYKFR---EFRV--AVV GDIREMFFQVRMKKQ--DQRSQM-----I------LWNNG---K-TE---------DEPD AYVVAVMTFGAACSPSSAHYV-KNRN------------A----DRF-EKEY--P-RAVEC I-KYE--HYVDDM-LASVE-T---EEEAVKLATEVR-TI-HSEG-------GFEIR-NWL SNSS-KV-VTSL--HE---NSTT---EKNMSF-----------------------STE-M ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF QRPFSYTGIDYFGPMT-------------------------------------------- ----------------------------VL--VG-R-----R-AE-----KR-WGV---L -LTCMT--TRGVHIEVAHSLTTDSC-----ILALRNF-IARR-GAPLEIISDRGTNFIGA SRELC-E-------ALKHVNEE-E----------------------LM---VEFVSPDTK ----WTFNPPAAPHFGGCWERLIQSVKKTLHDFEP------P-RLP----SDEIL----- --RTM-----LLEIEMILNSRP--------LTD------------I-------------- ----------------------PL-------------DN--------------------- ----------- >295/1-548 ---PTKREVLRVLMSIFDPLGLIGHFLMFLKVLLQE-VWRS-G----------V------ -QWDE-G-ITD--DAFTKWKQWLKLLPQVE---Q-VQVP--RCY--R------------- -SPSHDI-ID-RA-ELHT-FADASEC-GMS-AVVFLR--IIR--NG------TIEC-R-- IVAA---------------------------KTRV-APL--K-F---------------- --------------------------------VSIPRMELQAAV-VGA-RLAHTITDS-- -L------S-IEI---SKR---YY---------WT------------------------- -----------------------------------RVWYLPVFPV-------VNPN-K-P GKV-RLVWDCAAC-S-FG---VSLNSTLLKGPDQL--CSLLSILLQFR---ENRV--GLT GDIREMFHQVRIQDD--DQQCQR-----F------LWWNE---K-GE---------I--V VYVMQVMTFGACCSPSCAQFV-KNIN------------A----ERY-AAEF--P-KAAQV I-QKK--HYVDDM-LVSLE-S---EEEAVQIAREVK-YV-HQQG-------GFEIR-NWI SNSP-AV-LRAL--NE---KGVTLMGDKDLDL-----------------------TXE-V ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY SPPFTHTGIDFFGPYE-------------------------------------------- ----------------------------VA--VG-R-----R-TE-----KR-WGM---L -ATCLT--IRAVHIEVVASLSTDSC-----IMAIRNF-MSRR-GTPRVIYSDRGTNFIGA SRQMK-E-------AAAAVNVD-Q----------------------VM---KEFVNVDTA ----WSFNPPLAPHMGGSWERLIGSVKRNLQTINP------P-RNP----TDEVL----- --RNL-----LIEVENIINSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >296/1-555 ----TKRKVMSYIAQIFDPLGLVGPTIVVAKLFMQR-LWAL-K----------Q--NGES CEWDT-P-LPV--KLQAEWKDFHSTLHMLG---E-IRVP--RFV--S------------- --LP-N-AV--NL-QLHF-FSDASKG-AYG-SCCYVR--AET--SN------GVSI-Q-- LLTA---------------------------KSKV-APL-------S------------- ---SR---------------------------HSIARLELCAAR-LSS-QLFQKVFSA-- -L-K----I-P-----LPA---YF---------WT------------------------- -------------------------------------CYIPHHAV-------FKES-STT TKV-RVVFDASCKTS-SG---HSLNDTLVVGPVVQ--EDLHLIVLRFR---IRCI--ALV ADVEKMYRQILHFPE--DRRFLR-----I------RFRKS---S-TD---------PI-S TYELQTVTYGTASAPYLATRT-LQQI------------A----HDN-GHLY--P-AAVDP V-IYD--FYIDDL-LSGAN-D---VESAIQVREQVT-SM-LNDA-------GLPIK-KWA SNVP-EV-LDGVPPEDLALQP--L-H-DLQ---------------------------D-- -EQAV-----------------ST--LG-------------------------------- -----LMW---------------------------------------------------- ----------------------------------------------------------SP TRPFSVCGVDYCGPFF-------------------------------------------- ----------------------------IKSS--VRNR---APT------KA-YVA---I -FVCFA--TKAVHIELVSDLTTAAF-----LAALRRV-VARR-GRIAELHSDNATTFKGA SHALN-R-------VYRMLKVD-NSD-----------------RNRIF---SWCSENEIR ----WKFIPPRAPHFGGLWEAAVKSAKKHLLKTVG--N-----TNI----AYEPM----- --VTL-----LAQVEMCLNSRP--------LTP------------M-------------- ----------------------PS--------EP-------------------------- ----------- >297/1-545 ---PTKRMALKIIMSLFDPLGLLAPYLIHGRTLIQD-LWRS-G----------I------ -QWDE-Q-MKD--DEHENWKRWVKLLPGIK---D-LSIP--RCY--F------------- -GDVDPR-CYKSL-QCHV-FTDASEA-SYG-CAVYFR--ITDD-YE------RVHC-T-- LIMA---------------------------KSRV-APL--Q-H---------------- --------------------------------LSIPRLELEAAV-LGA-KLLNTVMTN-- -H------S-LKP---RKV---YL---------WS------------------------- -------------------------------------WYLPLGLV-------THPK-K-- QKK-RLVWDARAQ-V-NG---ISLNSQLLKGPDLL--VSLPSVICKFR---EKRV--GFG GDIREMFLQLRMRTS--DKYFQC-----F------LFRSD---S-QQ---------P-PE VYIADVAMFGATCSPCVAQHV-LRVN------------A----DKW-AKEF--P-QAAAA I-KDK--TYMDDY-YDSAD-T---PEEAAELAVQVR-TI-HAHG-------GFEMR-NWV SNSA-EV-LEKL--GE-----SAVVETRIL-Q-----------------------SSVEE RW--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------SN VRPFSYVGIDYMGPLE-------------------------------------------- ----------------------------VS--VG-R-----R-KE-----KR-YVV---V -FTCMV--VRAVHLEVAYDLSSDSC-----IMAIRRF-TRRR-GSPVEIFSDNGTNFVGA SRELQ-K-Q------VER-IDL-E----------------------CA---GTFTDARTK ----WSFNPPSAPHMGGVWERMVRSVKEAMAA-LE--D---G-RKL----TDEIL----- --WTT-----LVETEGLINSRP--------LTY------------M----PQ-------- -------------------------------------EL--------------------- ----------- >298/1-604 -----KRTVISDLARIFDPIGLLGTVIVSAKIFVQN-LWKQ-K----------I------ -PWDE-P-LSP--ELQALWLEFRTSLTKLE---T-LQIP--RWI--A------------- --FRKE-CL--SV-ELHG-FCDASTK-AYG-ACLYVR--CTHF-DG------TVTS-N-- LLIA---------------------------KSRV-APL--A-ELGK------------- ---KRKK-------------------------LTIPRLELSSAV-LLA-HLYEKVSAS-- -I-K----V---S---AQS---YF---------HT------------------------- -----------------------------------PEYFIPHHCV-------IKPD-STT TKL-RVVFDASCPTS-SG---VSLNNALMVGPTVQ--DDIISIVLRFR---FHKI--AIV ADVEKMYRMVQQQLA--DRKLHK-----I------LWRDN---E-ND---------PI-R VFQLNTVTYGTASAPYLATKC-LKRL------------A----ELD-GNKF--P-EAAKI L-YND--FYVDDM-MSGVD-D---VEEGKKICSDIQ-QL-LQGG-------GFNLR-KWS SNCS-AV-LENIPEELQDDRT--S-F-ELD---------------------------D-- SSATI-----------------KT--LG-------------------------------- -----LVWEPRLDVFRFKIPDWNTSEICKRTVISDLARIFDPIGLLGTVI---------- ----------------------------------------------------------TP APPFLRVGVDYCGPFA-------------------------------------------- ----------------------------VRYP--NRTK---ISV------KH-YAA---I -FVCLV--TKAIHIEMVADLTTQGF-----VAALKRF-VARR-GKPTLIMCDNGTNFVGA RRELD-E-------LAVLFKNQ-QS------------------QQSIA---LGAADIGIE ----FKFIPAKSPNFGGLWEAAVKSMKQHLRKTIG--L-----KTV----TPEEL----- --NTV-----FAQIEACLNSRP--------LTQ------------M-------------- ----------------------SS--------DPN--D-------L-------------- ----------- >299/1-503 ---NTKRQMISDSARLFDPFGWLAPVTVKIKILYQH-LWLF-D----------V------ -SWDD-P-LPA--AVEADWQSVKESLSQLE---A-IRIP--R-C--I------------- -FPNRGR--I----QLHG-FSDASEQ-AYA-AVVYAR--TTDE-QG------DVSV-V-- LVAA---------------------------KSRV-API--K-Q---------------- --------------------------------ISLPRLELNGAH-LLA-DLMHQITEA-- -L------P-HVQ---VEH---WA---------WT------------------------- ------------------------------------------------------------ ----------------------------------N--ADLFAIALRFR---SHRI--AFC ADVAKMYRQVLVHPA--DRDYQR-----I------VFRDE---P-DQ---------PL-R HYRLCTVTYGTKTAPFLAIES-MREA------------A----KPY-EAVY--P-KAVEA I-KFD--FYVDDF-LSGAD-D---EEEASQLKDQVV-EI-LSSA-------GFELR-KWS SNNK-KL-LPTNDEDEASSVPMKM-LNDSE------------------------------ ---TV-----------------KA--LG-------------------------------- -----INW---------------------------------------------------- ----------------------------------------------------------LA TRAFSHVGVDYAGPVR-------------------------------------------- ----------------------------LKAT--CVRG---VKIT-----KG-YLV---V -FVCLS--TRAVHLEVASDLSSDTF-----IGALKRF-ISRR-GYPVEIRSDNGTNFVGA DRKLR-E-------FVEQILTH-SK--------------------DAS---RYLSNLGIN ----WVFNPPSAPHMGGIWEAAVRSVKKHLVAELG--E-----SAI----TFEHL----- --STL-----LCQIESCLNSRP--------LCP------------L-------------- ----------------------ST------------------------------------ ----------- >3/1-540 -----KRVVLSTLAKIFDPLGWLAPVTVSGKLFIQK-LWIN-K----------S------ -EWDQ-E-LSI--EDKNYWEKYKENLLLLE---N-IRIP--RWI--N------------- --SNSS-----SVIQIHG-FADASEK-AYA-AVVYAK--V------------GPHV-N-- IIAS---------------------------KSRV-NPI-------K------------- ---NR---------------------------KTIPKLELCAAH-LLS-ELIQRLKGS-- -I------D-N-I---MEI---YA---------WS------------------------- ------------------------------------KYFLPHQAV-------IRDS-SLT TKL-RVVFDASAKTT-NN---KSLNDIMWVGPRVQ--KDIFDIIIKWR---KWEF--VVS ADIEKMYRQIKIDNN--DQKYQY-----I------LWRNS---P-KE---------KI-K TYKLTTVTYGTASAPYLATRV-LVDI------------A----DK--CK-N--Q-VISAI I-RND--FYMDDL-MTGAD-S---VEEANKLITLIP-HE-LQKV-------GFNLR-KWI SNNS-KI-LTTVEDTGDNKVL------------------------------------NII ENECV-----------------KT--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TM TFPFLNTGIDYAGPYY-------------------------------------------- ----------------------------VKCS--KNRG---QKTF-----KG-YVA---V -FVCMA--TKAIHLEMVSDLTSDAF-----LAALRRF-IARR-GKCSNIYSDNGTNFVGA ARKLD-Q-------ELFNAIQE-NI--------------------TIA---AQLEKDRID ----WHFIPPAGPHFGGIWEAGVKSMKYHLKRIIG--D-----TIL----TYEEM----- --STL-----LCQIEACLNSRP--------LYT------------I-------------- ----------------------VS--------EK-------------------------- ----------- >300/1-552 ---PTKRTVLRAVMSLFDPLGLMSFFIIHGKVLIQD-IWRA-K----------T------ -DWDE-P-IPE--KLCHRWWQWTKLCGQLD---R-IRIG--RCY--F------------- -PNCGGE-KCESL-QLHI-FVDASEG-AYA-CVAYFR--AIY--GG------KVQC-A-- LVAA---------------------------KSKV-APL--K-S---------------- --------------------------------LSIPRMELQAAV-LGV-RLQKLIRQS-- -H------S-LPI---SQC---FY---------HT------------------------- ---------------D---------------ADPRRIWYLPLGVA-------LNPK-K-P EKI-RIFCDAAAT-V-DG---VSLNSMLLKGPDFL--SSLPAVLFGFR---EKRY--AIC ADIQEMFHQIRIKKE--DRHAQR-----L------LWRDS---P-ED---------D-PA VYLMDVATFGSTCSPCSAQYV-KNLN------------A----AEH-AEEF--P-AAANA I-IKK--HYVDDY-LDSAD-T---IDEAVQLAKEVR-TV-HSRG-------GFHIR-NWM SNAE-EV-LRRV--GE-PSKA----TSKQLNL-----------------------D-KSN TT--E-----------------RI--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------AY VRPFSYVGLDYFGPLA-------------------------------------------- ----------------------------VR--VG-R-----A-TV-----KR-WIA---L -FTCLT--IRAVHLEVVHSLSTESC-----KMAIRRF-VGRR-GAPLEIHSDNGTNFVGA NNDLR-R-E------LAN-ITA-D----------------------LA---ETFTNTSTK ----WRFIPPAAPHMGGSWERLVRSIKTALNA-MY--T---S-RTP----NEETF----- --ATL-----IIEAESVVNSRP--------LTF------------V-------------- ----------------------PV-------------DP--------------------- ----------- >301/1-556 ---PTKREVLRVLMTIFDPLGLIAPFLMFLKILLQE-IWRS-G----------I------ -QWDD-K-IDD--NAFAKWCSWLRVLPQVE---Q-VQIP--RCF--C------------- -SQTSSE-YD-DV-QLHT-FVDASEN-AMA-AACYLR--FER--NS------FVWC-R-- LVAA---------------------------KTRV-APL--R-Y---------------- --------------------------------HSIPRLELMAAV-IGT-RLSQTVTES-- -L------S-ITP---SKQ---FF---------HS------------------------- -----------------------------------RVWYLPVFPV-------TNPN-K-P GKV-RIVWDAAAK-A-FG---VSLNSALLKGPDHL--SSLFTVLIRFR---ERPI--ALT GDIREMFHQVRIRPE--DQQCQR-----F------YWRDD---D-GN---------V--A VYVMCVMTFGACCSPSSAQYA-MNLN------------A----QRF-AQKY--P-AAVEV I-EKR--HYVDDM-LVSVD-T---EEEAVELAKEVR-YV-HSQG-------GFEIR-NWT SNSQ-RV-LEAL--RG---SNTE---EKNLDL-----------------------SPE-L GT--E-----------------KV--LG-------------------------------- -----MWWCTASDVFTYKV----------------------------------------- ----------------------------------------------------------AF ARPFTHIGVDYFGPLE-------------------------------------------- ----------------------------VV--VG-R-----R-VE-----KR-WGM---L -VTCLT--TRAIHIEVVHTLSTDSC-----IMGLRNF-AARR-GTPKTIYSDRGTCFIGA SRELM-N-------VAAGFNQD-D----------------------LM---KEFGGTETT ----WKFNPPASPHMGGSWERLIGIVKRNLMAIRP------S-HKP----NDEVL----- --RNL-----LAEIENTVNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >302/1-551 ----TKRQLFSEVAKMFDPLGLLAPITVLAKRLMQQ-TWAS-K----------I------ -GWDE-S-LTE--DLLADWLHLRNSLETVR---D-IKIP--RPI--I------------- --GL-G-YE--SV-ELHG-FADASGI-AYG-ACLYVR--SILP-NG------CCVV-R-- LLCS---------------------------KSKI-APL-------Q------------- ---E----------------------------LTIPRKELCAAV-LLS-RLVKKVNST-- -L-Q----S-Q-F---SAI---CL---------WS------------------------- -------------------------------------------------------S-STS TKL-RVVFDASAK-PPSG---VSLNEVLKIGPVVQ--SDLLSILLRFR---KHPF--VFT ADIQKMYRQILVDKE--QTALQR-----I------FWRSN---P-TE---------SI-K VLELLTVTYGTSAAPYLATRS-LVQL------------C----IDE-GADF--P-LAARI I-QED--CYVDDV-LSGAR-T---IQEAVECRQQLQ-AL-LAKG-------GFPVH-KWC ANDE-AI-LQDVPESEREKLV------LLD---------------------------DLS ANEVM-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TP SAPFEVTGVDYAGPFL-------------------------------------------- ----------------------------IK--QAGRKS---VAI------KA-YLC---V -FVCLV--TKCLHLELVSDMSTAAF-----IAALQRF-VSRR-GLVRELHSDNGSNFRGA KAELH-E-------LYSMFREN-AA------------------VNQIA---SFCQTKEID ----WHFIPPDAPEFGGIWEASVKSTKYHLKRILK--G-----TPL----TFEEL----- --YTL-----LTQVEAILNSRP--------LFS------------H-------------- ----------------------SD--------DPS--D-------GEVITPAHF------ ----------- >305/1-566 ----TKRYVLSVIASLFDPLGLLGAAITSAKIFMQL-LWTL-H----------D-DHNQR LGWDQ-P-LPS--TVGESWRRLHVQLPLFN---E-IRIN--RCV--I------------- --IP-D-AA--LI-ELHC-FSDASEK-AYG-ACLYVR--SENL-AG------EVLV-R-- LLTS---------------------------KSKV-APL-------K------------- ---C----------------------------QTIPRLELCGAL-LAA-QLFEKAAQS-- -I-R----F-T-----GNS---YF---------WT------------------------- ------------------------------ELETIKRCYLPHHPV-------IKEA-STT TKV-RVVFDASCKTA-TG---ASLNDILLTGPIVQ--EDLRSIILRSR---TKQI--MLV SDVEKMFRQIYVDTK--DRPLQS-----I------LWRNS---P-SD---------IA-L TYELNTVTYGTKPAPFLATRT-LQQL------------A----FDE-EKNF--P-LAASA A-TDD--TYMDDV-ITGAD-N---AEMAIEMRKQLD-EM-SSSG-------GFRLR-KWA SNCP-VV-LEGVAEEDRAIRTSEG-I-VLD---------------------------P-- -DPSI-----------------RT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV SRPFLRTGVDYFGPLY-------------------------------------------- ----------------------------VRLA--PRRP---A-V------KA-YVA---I -FICMS--TKAVHMELVSDLSTDRF-----LQALRRF-ISRR-GRCTDMFSDNGTNFVGA RNKMQ-E-------VLKMLQDC-NY------------------HESIT---RELAKEGIQ ----WHFNPPSAPHFGGLWESAVRSAKHHLVKVIG--D-----TPV----TPEDM----- --CTL-----LAQVEACLNSRP--------LTP------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >306/1-561 ----TKRTVLSDISRLFDPLGLIGPVIVQAKLFVQE-LWKR-E----------C------ -SWDS-P-LSE--DMTERWLEYRRNMIGLD---G-IRIP--RWI--G------------- --VTTS-RE--SV-ELHG-FCDASRK-AYG-ACIYIR--TVAA-DG------TVDV-R-- LLTA---------------------------KSRV-APL--E-NLKK------------- ---KKKS-------------------------LSTPRLELSSAL-LLA-HLYEKVIDS-- -I-H----M---T---VES---HF---------WT------------------------- -------------------------------------YYMPHHAV-------FKPE-STT TKL-RVVFDASCKTS-TG---VSLNDALMVGPVVQ--DELININLRFR---LHRY--AVV ADVAKMYRMIAVSKH--DRKLQR-----I------VWRGS---S-DE---------EI-R TFELTTVTYGTASAPYLATRC-LKQL------------A----EEG-EESH--P-MAAAV L-RED--FYVDDM-LSGVD-E---IDEGKQFVEEMV-DL-MQSG-------GFTLR-KWN SNCE-EI-LRHVPEHLHDDRT--I-L-TLD---------------------------S-- SDSTV-----------------KT--LG-------------------------------- -----LQW---------------------------------------------------- ----------------------------------------------------------TP CSPFQRVGIDLCGPFQ-------------------------------------------- ----------------------------VKYP--QRSA---RPV------KC-FVV---V -FVCLV--TKAVHLELVADQTSQAF-----LASLRRF-SSRR-GKPSLIMCDNGRNFVGA KRELA-E-------LRKLFVNQ-QF------------------QNAVV---QESSKDHIE ----FRFIPARSPNFGGLWESAVKSFKTLLKRTIG--S-----RTL----QYDEF----- --QTL-----LTQIEAVLNSRP--------LTP------------V-------------- ----------------------SN--------DPS--D-------Y-------------- ----------- >307/1-577 ----TRRGILSAVSSLYDPLGFVAPVILEAKLLLQC-LCRQ-E----------L------ -KWDD-E-ISE--VEADRWRAWLSCLPQLH---D-VHIS--RCF--K------------- -PKEFGK--KLTY-EMHH-FADASKI-AYG-AVSYLR--ITDE-EN------RVHC-S-- FLIG---------------------------KSRL-APL--N-T---------------- --------------------------------KTIPRLELTAAV-LAV-KLDRLLRKE-- -L------D-LLI---TSS---TF---------WS------------------------- ---------------V---------------VTENRTWYLPHHPV-------LNPR-K-P DKL-RIVFDCAAR-S-KN---VSLNDVLMQGPDLV--NNLVGVLTRFR---TEPI--ALI ADVEAMFHQVKVEPQ--DRDALR-----F------LWWPG---GNLH---------SVPV PHRMKVHLFGATSSPSCAAFC-LKQA------------A----HVY-GNEY--DPRVVEI V-KRN--FYVDDC-LSSVR-D---ANDGIEIVTQLR-SL-LAKG-------GFRLT-KWL TNDA-SV-LQSI-------PEEDRAKSVKTRQ-----------------------I--DD -GINE-----------------RV--LG-------------------------------- -----VHWSVTTDEFGFNV----------------------------------------- ----------------------------------------------------------YN EPPFSHVGVDYFGPLL-------------------------------------------- ----------------------------VK--QG-R-----S-EV-----KR-YGC---L -FTCLT--IRAIHIEMAHSLSTDSF-----IASLRRF-IGRR-GPPRCIYSDNGTNFVGA ERILR-E-------SLQAWNQQ-Q----------------------VN---EFLRQKGVI ----WTFNPPSASHMGGAWERMIRSVRRILTTLTN--A---Q--LV----TDEAL----- --GTF-----LVEVESILNSRP--------LIP------------V-------------- ----------------------TF-------------DHRDDEPLTPNHL---------- ----------- >308/1-555 ----TRRGILSTVSSIYDPLGFLGPVTLEGKQILQQ-MCIE-K----------T------ -DWDD-P-LPN--NLRARWEFWKQDLKQLE---N-LEIG--RCF--Q------------- -PPNFGR--ILCR-ELHH-FADASTV-GYG-QCSYMR--LVSE-SG------SISV-S-- LVIG---------------------------KSRV-APL--K-P---------------- --------------------------------MTVPRLELTAAL-VSA-RMSAYLQKQ-- -L------G-PET---YEN---YY---------WS------------------------- ---------------I---------------NTSRRLWYLPHHPV-------FNPR-K-P DKM-RIVFDCTAQ-Y-KG---TSLNQVLMQGPDLV--NNLVGVLTRFR---KHFV--AIT ADIESMFHQVNVDPR--DRDCLR-----F------LWWPQ---GDLS---------VEPK PHRMTVHLFGATSSPSCAAFC-LGQS------------A----IDF-GGQY--EPYVTSI V-ERN--FYVDDC-LVSVP-S---VEVGIRVVKELQ-KL-LSQT-------GFRLT-KWL SNSA-EI-VNSV-------NIKDRAKSVKVVS-----------------------A--ND -NVQE-----------------KV--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------KE GAPFTYCGVDCFGPFL-------------------------------------------- ----------------------------IR--NX-R-----S-TI-----KR-YGV---L -FTCMS--TRAIHLECAHSLDTDSF-----INALRRF-LXRR-GPIEQLRSDCGTNIVGA RNELC-Y-------ALKSLDDK-Q----------------------VK---KFALENGFD -WIDFKFNVPHASHMGGVXERQIQTARRALEPLLA--K---CGEQL----DDEAF----- --STF-----LTEVXNIVNSRP--------LTV--------------------------- ------------------------------------------------------------ ----------- >31/1-555 ----TRRGMLSVTNSLFDPLGFVAPVVLEARLIYRD-LCLM-K----------T------ -DWDE-E-VTG--TELERWKAWCNSLNELT---R-IRIP--RCF---------------- --KPQVRHPTPGV-QLHV-FADASTA-ARG-CVCYLR--TTFE-DD------NTTC-S-- FVMG---------------------------KSLLCDSG--K------------------ --------------------------------HTIPRLELEAAL-DAV-KLSRTVKRE-- -L------G-LDD---CPC---IY---------WT------------------------- ---------------V---------------NTTNKLWYLPHHPV-------INPK-K-P SKV-RIVYDCAAK-C-EG---QSINDKLMKGPDLV--NPLVGVLMRFR---RERV--AIV SDIEAMFHQVLVAQK--DRDALR-----F------LWWPG---GDLT---------KSPV PHRMKVHLFGARSSPCCATFC-LRET------------A----REF-GKFF--HPRVAEV V-KNN--FYVDDC-LVTAV-D---DQAGIQLVKDLR-NL-LSMG-------GFKLT-KWL STSV-AV-MESV-------PADDRAKVIQDIP-----------------------L--GG -EVHE-----------------RV--LG-------------------------------- -----INW---------------------------------------------------- ----------------------------------------------------------ID EPPFTHTGVDFFGPLL-------------------------------------------- ----------------------------TK--LR-R-----S-EV-----KR-YGC---L -FTCMT--TRAIHLEVATDLSTDAF-----INALRRF-TARR-GPVTHLYSDNGTNFVGC ERILR-E-------CIEEWNRN-Q----------------------VG---DYLRQKNII ----WKFNPPAASHFGGAWERLIRSVKFILQALLQ--G---K--PL----DDDLL----- --HTL-----LVEVEDIVNSRP--------LTQ------------V-------------- ----------------------PL-------------E-----------I---------- ----------- >310/1-541 ---PTKRQLLSLVMSVFDPLGLVAPFVVHGKSLVQD-VWRS-G----------I------ -GWDE-Q-IPI--DLVPRWEQYTTLLGTLD---K-VRIP--RCY--F------------- -PGYSQE-SYNST-ELHV-FVDASSA-AYA-AVAYFR--IED--RG------VVRC-S-- LVSA---------------------------KTKV-APM--K-L---------------- --------------------------------LSIPRLELQAAV-IGM-RLMKTIMSN-- -H------T-LPI---TRK---VL---------WS------------------------- -------------------------------------WFLPLGIV-------VNPK-K-P DKV-RVVWDAAAS-V-QG---VSLNSVLLKGPDLL--TPLQTVLSRYR---QREI--AIS GDIMEMFHQVLITRP--DRSAQM-----F------LWRDQ---P-SD---------A-IQ VYVMDVAIFGATCSPSSTQFV-KNLN------------A----EEY-ATEF--P-NAAVA I-KEN--HYVDDF-LDSVD-T---VDEAVQLALDVK-KV-HEKA-------GFLIR-HWM SSSS-EV-LQRI--GE-QNTM----AVKSFTM-----------------------D-KGS HM--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ------------------------------------------------------------ --AFTFTGLDYFGPIT-------------------------------------------- ----------------------------VR--YG-R-----G-ST-----KR-WVA---L -FTCLG--TRAVHLEIAHTLSTESC-----KMAIRRF-ISRR-GAPQEIYSDQGTNFQGA SAELK-Q-Q------IGA-INL-D----------------------MA---ETFTNTETQ ----WKMNPPYAPHMGGVWERLVRSVKSGLAN-MP--L---T-RNP----DEETL----- --QTA-----IVEVESIVNSRP--------LTY------------L-------------- ----------------------PI-------------DS--------------------- ----------- >311/1-546 ---PTKREVLRTLMMIFDPLGFMSHFLMYLKVLLQE-IWRS-S----------V------ -NWDT-P-IEE--PQFQKWLTWLKVLPEVA---N-VQIP--RCY--R------------- -TSVMLD-NTCKV-KMHT-FVDASEN-GFA-AVVYLR--YEK--AD------VIET-S-- FVCA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQASV-LGM-RLANSIAQS-- -L------S-IGL---SGR---YF---------WT------------------------- -----------------------------------REWYLPVFPV-------HNPN-K-P GKL-RLVWDAAAT-A-QG---ISLNSMLLKGPDQL--TSLLAVLIQFR---EFRI--AVC GDIKEMFHQVLMRKE--DQHCQR-----F------YWKQN---T-SE---------GMPD VYVMKVMTFGACCSPTTAQYV-KNLN------------A----KRF-ERQS--P-VAVDA I-VKK--HYVDDM-LVSVE-T---EEDAIKLAQDVK-RI-HAAG-------GFEMR-NWL SNSP-IV-AASL--QE---VTAA---EKSF-------------------------GEE-N LT--E-----------------KV--LG-------------------------------- -----LWW---------------------------------------------------- ----------------------------------------------------------AY SRPFTHMGVDYFGPII-------------------------------------------- ----------------------------VS--AN-R-----K-RE-----KR-WVL---I -ATCLT--VRAIHLQIAHTLSTDSC-----ITALRNV-IARR-GTPAVIYSDRGTNFRGT CKELK-A-------ALQSLDHE-R----------------------MM---TEFTTPHTS ----WSFNPPASPHMGGAWERLIRTVKQNLSKLLP------D-RSL----SYEVL----- --ENL-----LVEVENIINSRP--------LTS------------I-------------- ----------------------PL-------------ED--------------------- ----------- >312/1-578 ---PTKRKVLSIIATLFDPLGLLGAAITSAKIFMQQ-LWSV-Q----------D-EKGQK IDWDQ-P-LPS--TVGEIWLKLRSQLPTFN---Q-ITID--RCV--V------------- --IP-G-AV--SM-QIHC-FSDASEK-AFG-ACVFMR--SVNA-EG------SIMV-R-- LLTS---------------------------KSRV-APL-------K------------- ---C----------------------------QSIPRLELCGAL-LAA-QLCEKVQAS-- -L-K----R-T-----MET---FF---------WT------------------------- ------------------------------TQESVQRCYLPHHPV-------VKEA-STT TKV-RVVFDASCKTA-SG---VSLNDVLLVGPVIQ--EDLRSIVLRCR---TRQI--MLV SDVEKMFRQIYVCKE--DRPLQC-----I------LWRSS---P-ID---------DV-E VYELNTVTYGTKPAPFLATRT-VKQL------------V----EDE-EQRY--P-LAAQA A-SED--VYMDDV-ITGAD-N---VETALNLRDQLD-QM-MSGG-------GFRLR-KWA SNCP-KV-LEGIPPEDLAIKQSSG-V-NLG---------------------------P-- -DPSV-----------------KT--LG-------------------------------- -----LTWVPKTDVLKFQF----------------------------------------- ----------------------------------------------------------TV SRPFSRTGVDYFGPVY-------------------------------------------- ----------------------------IRPA--PRRP---A-V------KA-YVA---L -FICLC--TKAVHLELVTDLSTDRF-----LQALHRF-VARR-GKCSDIYSDNGTNFVGA RNKLQ-E-------FLKLLKDQ-TH------------------REIVA---KDCAMQGIQ ----WHFSPPSAPHFGGLWEAAVRSAKKHLLKVIG--E-----DPV----SPEDF----- --STL-----LVQVEGCLNSRP--------LTP------------M-------------- ----------------------SE--------DPE--D-------L-------------- ----------- >313/1-543 ---PTKREVLRVVMSLFDPLGLIAFYVVHGKILMQE-IWVS-G----------V------ -HWDD-P-ISQ--QLYDRWIQWCRLLPQLS---S-IRIP--RYY--F------------- -PKAESE-VYRSL-QVHV-FVDASES-AYS-SVAYFR--VES--QH------GPLV-A-- LVGA---------------------------KTKV-APL--K-M---------------- --------------------------------LTIPRLELQAAV-LGT-RLLNNVISM-- -H------G-LPV---VQR---FL---------WT------------------------- -------------------------------------WYLPLGVH-------KNPK-K-P EKI-RLTWDGRAS-V-QG---VSFNSALLKGPDML--SSLPSVLCHFR---QYRY--ALT GDIKEMFHRIRIREE--DRQFQR-----F------LWRNA---P-HD---------P-PK IYVMDVATFGSTSSPCSAQYV-KNLN------------A----SDF-TEKC--P-RAVYA I-HHY--HYVDDY-LDSFS-S---RDEAITVGRQVK-MI-HSEG-------GFELR-NFL SNDA-QI-SARV--GE-----ESTENDKSLSL-----------------------D-G-- -A--E-----------------SV--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------PY VRPFTFVGIDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NS-----KR-WIA---L -FTCLT--IRAVHLEVVHNLTTESC-----VMAVRRF-VSRR-GSPAEIYSDNGTNFHGA DNQLK-R-E------IEE-RNY-R----------------------MA---TVFTNSTTR ----WRFNPPGAPHMGGVWERMVRSVKAAIGTILE--T---Q-RRP----DDEVL----- --ETV-----MIDAEAMINCRP--------LTY------------I-------------- ----------------------PL-------------EY--------------------- ----------- >314/1-545 ---PSKRTLLSDIAKLYDPLGIYGPITVMLKILFQE-SWIT-S----------L------ -PWDE-P-LPE--KLCARWHVVRDELCLLQ---T-CRIS--RYI--A------------- --IPNT-----DI-ELHG-FADASAQ-AYG-AVVYSR--VKFG-D-------SYQV-T-- LIAS---------------------------RTRV-APL-------K------------- ---P----------------------------ISIPRLELNAAH-LLS-KLMTIIKQS-- -L-T----I-S-I---SSS---SC---------WT------------------------- ---------------------------------------------------------SST PKC-RVVFDGSGKDE-KG---FSLNDRLHIGPSIQ--RDLLGVCLRFR---QHRY--VFC ADIEKMFRRILVSSK--HTNYQR-----I------IWRKE---E-DE---------PF-Q HYRLLTVTYGLGPSPFLAVRV-LKQL------------A----DDY-QEKY--P-LASIA L-ARD--AYVDDI-PTGCD-S---VNELIALKDDLI-SL-LNEA-------NFKLH-KWS SNCD-AL-LQTIPKEI-CEHH----PSNET------------------------------ -LTIV-----------------KI--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------QP LRCFLHTGVDYAGPIA-------------------------------------------- ----------------------------IKIS--TGRT---PKFG-----KA-WFA---V -FVCLS--TKAIHLELVSDLTSSAF-----IAALERF-WARR-GPITDMYSDNGTTFQGA QKELK-E-------IRELLLLQ-NQ------------------PQELA---NFVAQHGIN ----WHFIPPFSPHFGGLWESCVRSIKLHLRRVVG--A-----HVL----TFEEY----- --STV-----LAQIEGILNSRP--------LCS------------A-------------- ----------------------GD--------TS-----------LDPLTPSHF------ ----------- >315/1-543 ---PSKREVLRVLMSIFDPLGLIAHFLIYLKVLLQE-IWRS-G----------A------ -QWDD-E-IND--VLFLKWQIWLRVLPEVE---N-VQVS--RCY--Y------------- -LKDSPD-NE--I-ELHT-FVDASEN-GYA-AVSYLR--TSN--DG-------VEC-T-- LITA---------------------------KTRV-APL--K-F---------------- --------------------------------QSIPRLELQAAV-LGA-RLARTIAES-- -L------S-IRT---TRR---CF---------WT------------------------- -----------------------------------RSWYLPVFPV-------FNPN-K-P GKL-RIVWDAAAT-I-FG---VSLNSALLKGPDQL--CSLFSILLQFR---EHSI--GLT GDIREMFHQIKIREQ--DQPCQR-----F------FWKDE---S-GE---------T--A VFEMCVMTFGACCSPSSAQFV-KNLN------------A----ERF-VGQY--P-QAVEA I-IKR--HYVDDM-LASVK-T---EEEAIRLANEVK-HI-HSQG-------GFEIR-NWV SNSQ-TV-LRSL--GE---NDAK---TKSLDL-----------------------SAE-V AT--E-----------------KV--LG-------------------------------- -----LWW---------------------------------------------------- ----------------------------------------------------------AY ARPFTHVGIDYFGPME-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGM---L -ATCMT--TRAVHIEVAHSLSTDSC-----IIAIRNM-IARR-GAPRHIYCDRGTNFVGT SNELG-R-------VMHELDNE-S----------------------IM---SEFVDSGTS ----WSFNPPSAPHMGGSWERLIRSVKCSLKALNL------P-RRP----SDEVL----- --HNA-----LLEIENTINSRP--------LTH------------V-------------- ----------------------PI-------------ED--------------------- ----------- >316/1-558 ---PTKREVLKVIMSLFDPLGFVSFFLVHGKVLMQD-VWAA-G----------T------ -NWDE-Q-IND--ELCLRWRRWIQYFPQLD---T-VRIP--RCY--F------------- -STPFPT-SFDRL-EIHV-LVDASDA-AYA-CVAYYR--IET--ES------GIQV-A-- LICS---------------------------KTKV-APL--K-V---------------- --------------------------------LSIPRLELKAAV-LGT-RLLESIQGY-- -H------T-YPI---SRR---VI---------WS------------------------- -------------------------------------WFLPLGVV-------INPK-K-P EKI-RLIWDAAAK-V-DG---VSFNSHLLKGPDLL--TPLPKVLSGFR---LFPV--AVS GDIREMFLQIKLQER--DRRAQM-----F------VFRSN---P-DE---------P-LQ TYVINVTMFGSTCSPSSAQYV-KNLN------------A----EEF-AQEY--P-RAAIA I-KDH--HYVDDY-LDSFK-S---IDEAVDVVNEVK-YV-HSKA-------GFEIR-NFL SNEE-VV-LRKI--GES----EREL-SKDLAL-----------------------V-RAE IT--E-----------------SV--LG-------------------------------- -----MKWVPNYDVFTYTF----------------------------------------- ----------------------------------------------------------PF IRPFTYVGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-QV-----KR-WIA---L -FTCLT--IRAVHLEVVHSLSTQSC-----IMAVRRF-IARR-GSPAEFYTDNGTCFQGA SRELV-REQ------VLA-RND-A----------------------LA---TVFTNANTK ----WRFIPPAAPHMGGAWERLVRSVKVAVGAITD--A---P-RRP----DDETL----- --ETI-----MLEAESMINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >317/1-556 ---PTKRQVLRLVMSLFDPCGFIAHFIVHGKILMQH-IWRT-G----------T------ -EWDD-E-IPI--ELHGMWRDWIQLLKRLT---Q-VEVP--RCF--F------------- -GANNSK-VPATI-QLHV-FVDASEL-AYA-CCAYLR--IVQ--AG------VVHC-G-- IVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQACV-LGC-RLMETICVS-- -V------K-LTI---ERR---YL---------WT------------------------- -------------------------------------WYLPLGVV-------KNPK-K-P EKI-RLIWDAAAK-V-HR---LSLNDMLLKGPDMM--TSLFAVLLRFR---QRTI--AIC GDIREMFHQIRIIPQ--DKQSQR-----F------LFREH---Q-DD---------L-PQ IYVMDVATFGATCSPCSSQFV-KNKN------------A----KEF-ESQF--P-KAAEA I-TNA--HYVDDY-LDSVD-T---VEEAVQLVNEVK-YV-HALG-------GFEIR-NFS SNSS-EV-LRRL--GE-AER-----TSKSLDL-----------------------D-SSE HV--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PQ VRAFSYTGVDYFGPIL-------------------------------------------- ----------------------------VK--QG-R-----S-LV-----KR-WVA---L -FTCLT--IRAVHLEVVHSLSTQSC-----VMAIRRF-ISRR-GAPAAFYSDNGTCFKGA SNMLA-D-Q------LQT-IHE-G----------------------CA---LTFTNARTT ----WHFNPPSAPHMGGCWERMVRSIKVAMAAIAE--H---P-RHM----NDEAL----- --ETV-----ILEAEGMVNSRP--------LTY------------I-------------- ----------------------PV-------------DNAEEQALTPNHF---------- ----------- >318/1-529 ---PTKRQVLRVVMTLFDPLGLVASFTIHGKILIQN-IWRS-G----------V------ -GWDD-P-IIN--RDFLDWKRWISLLPELK---R-VHIP--RCY--F------------- -PNYERE-SYGSL-QLHI-FVDASEL-AYC-SVAYFR--IVD--RG------TPRC-A-- LVAA---------------------------KAKV-TPL--R-P---------------- --------------------------------QSIPRNELNAGV-IGV-RLMKSVMQN-- -H------S-LQI---TKR---YF---------HT------------------------- ---------------E---------------ADPSRVWYLPLGIV-------RNPR-K-P NKM-RLVWDAAAR-V-KG---VSLNSMLLTGPDLL--TPLMTVLCQFR---QKQF--AIT GDIKQMFHQLRIRKE--DRQSQR-----F------LWRAK---P-DT---------A-PD IYIMDVATFGATCSPCSAQYA-KNLN------------A----AEH-EAEY--P-DAARA I-TQN--TYVDDY-LDSRD-T---IEEAVQLAEDVR-EV-HSKA-------GFEIR-NWH SNAP-EI-LERI--G-----------VEN------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFTHTGIDYFGPLL-------------------------------------------- ----------------------------VK--QG-R-----S-NV-----KR-WVA---I -FTCLT--VRAVHLEVVHSLTIQSC-----KMAIRRF-VDKR-GAPQNIFSDNGTYFRGA ARELA-S-E------IKS-IHR-A----------------------LA---GTFTNAETE ----WHFNPPSAPHMGGVWERKVRSVKDAFKV-LA--H---R-EKL----DDEGL----- --LTL-----LAEASMIVNSRP--------LTF------------V-------------- ----------------------PL-------------ES--------------------- ----------- >319/1-545 ---PTKREMLRVLMSMFDPLGLISQFLVYLKILLQE-VWRS-G----------V------ -DWDD-K-IEG--VLFEKWQTWLRVLPQVE---N-LQIP--RCY--F------------- -CQLSAA-SG-TV-QLHT-FVDASEN-GMA-AACYLR--ITR--DN------VVEC-S-- LVAA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRLELQAAV-IGT-RLARSVSEA-- -L------S-IQI---SRR---IF---------WS------------------------- -----------------------------------RVWYLPIFPV-------TNIN-K-P GKI-RMVWDAAAT-A-YG---VSLNSVLLKGPDQL--CELFSILIQFR---EGRI--ALT GDVREMFLQVLMRPV--DQQCQR-----F------LWYEE---D-GT---------L--S VYILQVMSFGACCSPCSAQYV-KNLN------------A----ERF-KNDY--P-TAVEV I-QKR--HYVDDM-LVSVD-T---EDEAIQLAQQVK-HV-HSEG-------GFEIR-NWI SNSK-HV-VQAL--QE---CQTE---EKNLDV-----------------------SSE-I AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TRPFTHVGVDFFGPYE-------------------------------------------- ----------------------------VV--IG-R-----R-AE-----KR-WGM---L -ATCLT--IRAIHIEVVHSLSTDSC-----IMALQNF-IARR-GKPRTFFSDRGTNFIGA RRVLQ-E-------TENAISQE-E----------------------LM---KEFMDADTN ----WTFLPPASPHMGGSWERLIGSVKKNLMAILP------A-RKL----TDEVL----- --RNL-----LTEIESIVNSRP--------LTH------------V-------------- ----------------------PI-------------DD--------------------- ----------- >320/1-581 --PLTRQKVLSEIAKFFDPLGLAGPVVTTAKLILRK-VGTLKN----------I------ -GWLD-P-VPE--SVANEWRRFRKQLPALN---D-FRVS--RWV--Y------------- --DERAERV-----ELHG-YSDASDD-AYG-ASVYAR--NIYP-DG------EITM-R-- LICS---------------------------KSKL-LPK--K-VKNV------------- ---PKE--------------------------ISTPKGELEGAL-LLA-ELVDKLVNV-- -VD-------VCF---DSV---NL---------WC------------------------- -----------------------------------SAYYLPHHCV-------LRPS-STT TKL-RVVFDGSAKTS-TG---VSINDALKVGPTVQ--NDLLSILLNFR---CYRY--VFT TDIPKMFRQIELHPE--DTPYQR-----I------LWRDD---R-SQ---------LL-K VFELKTVTYGLASSPFHATMA-LNQI------------A----EDG-EKEF--P-LASAA L-KKS--FYVDDG-LCGAQ-S---VEEARLLSRELR-KL-LNTG-------GFDAH-KWC ANDP-AI-LEDIPEELWGTTF------DLK---------------------------DAA AKSVV-----------------KT--LG-------------------------------- -----VAWNASQDWF----------------------------TFTVLPP---------- ----------------------------------------------------------QP APAFFHTGVDFAGPFL-------------------------------------------- ----------------------------IKSLTAARRP---MMT------KG-YVS---L -FVCMS--TRAIHLELVSSLTTDAF-----LAALRRF-TGRR-GLVNKMYSDNATNFVGS ETELE-R-------LAKLFAEE-QH------------------IEQVE---EFCSSHGIT ----WSFIPPRSPHFGGIWEAGVKSVKHHLKRVVG--N-----QKL----TFEEL----- --TTV-----LVQIEAVLNSRP--------LTP------------C-------------- ----------------------SN--------DPN--D-------L-------------- ----------- >321/1-557 ---PTKRIVLSVVMAQFDPAGFLGPITILGKILVQD-LWRT-G----------C------ -EWDE-M-IDE--LAFQRWLRWINILADAK---H-FKLP--RCY--F------------- -GNARWD-EIEEI-QLHI-FADAGDK-AYG-CVAYFR--AIVR-GE-------VVV-A-- LVMS---------------------------RSKV-APL--K-M---------------- --------------------------------LSIPRLELESCV-LAA-RMSQAIHDN-- -H------S-FPI---SKT---FF---------WT------------------------- ---------------K---------------TPSNAVWYLPLNVV-------LNPR-K-P DKT-RLVWDAAAS-V-RG---VSLNSQLLKGPDML--VPLPRVVCRFR---ERPI--ALG GDIQEMYHQIRIREE--DKQAQR-----F------LFREN---P-AD---------A-PQ VYVMDVATFGSACSPSSAQFV-KNLN------------A----DQY-AEEF--P-EAAAA I-KER--HYVDDY-YDSVD-T---VEEAIRRANEVK-FI-HSKG-------GFNIR-NWV SNSK-KV-LDAM--GE-----QSVKTSVHFNQ-----------------------E-KSA FY--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PN LRPFSYVGVDYLGPLD-------------------------------------------- ----------------------------VS--VG-R-----R-SE-----KR-WVA---L -FTCFV--TRAVHLEVAYGLTAQTC-----LMAIRRF-ICRR-GPPVEFFSDNGTNFRGA SKELV-E-T------VRS-IGN-D----------------------CA---EVLTTSRTK ----WTFNPPAAPHMGGVWERLVRSVKEALEA-LD--D---G-RRL----TDEIL----- --VTC-----LAEAEDMINSRP--------LTY------------V----AQESSQAEA- ------------------------------------------------------------ ----------- >323/1-565 ----TKRFILSTIALLFDPLGLLGPVIVTAKIFMQS-LWTL-L----------N-PNGER LDWDE-A-VPE--MVGEVWRRFHSQLALLN---E-LRIT--RCV--I------------- --CP-E-VF--KM-ELHF-FSDASEK-AFG-SGAYLK--SEDP-KG------RIFV-N-- LLTS---------------------------KTKV-APL-------K------------- ---S----------------------------QAMPRLELRGGV-LSA-ELYVQILQS-- -L-K----I-K-----IPT---FF---------WV------------------------- ------------------------------TPTQVNRCFLPHHPV-------VKEA-STT TKC-RVVFDASCKTS-SG---VALNDVLLAGPVIQ--EDLRSIILRSR---IKPV--MLV SDVEKMFRQIMVHPE--ERPLQS-----I------LWRFS---P-DE---------EV-G IYELKTVTYGTKPAPFLATRT-LKQL------------A----TDD-GPRF--P-LAARA V-NQD--TYMDDV-ITGAE-D---VQSAIELRKQLD-EM-MLRG-------GFKLR-KWA SNRQ-EV-LAGIAEENLAI-SMEE-I-NLD---------------------------T-- -DPGV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TT SRPFARTGVDYFGPLY-------------------------------------------- ----------------------------VRPA--PRRP---A-V------KV-YVA---L -FICLC--TKAVHLELVTDLSTERF-----IQALRRF-VARR-GICDDIYSDNGTNFVGA RNKMA-E-------LLLLLKDR-KH------------------RDIVS---KECSNQGIK ----WHFNPPSAPHFGGLWEAAVRSTKKLLLKTIG--E-----TPV----TAEDL----- --NTL-----LVQVEGCLNSRP--------LTP------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >324/1-544 ----TKRQVMSDIAKLYDPLGLLGPTVVIAKLIMQD-LWKG-R----------L------ -QWDE-P-LAE--SQLATWTKLRRELPEIV---G-RKIP--RRV--T------------- --T--D-AA--SYQELHG-FSDASRK-AYG-CCVYIR--NVQS-EG------PAVM-N-- LLCA---------------------------KSRV-APL-------K------------- ---ELDRQEKDDMKPAE---------------LTTPRLELCAAL-LLA-QQIAKVTEA-- -L-E----I-D-V---NRV---VL---------WS------------------------- -------------------------------------------------------D-SST TRL-RVVFDASMKSS-SG---TSLNDLLKIGPQVQ--DPLFSIMLRFR---LPKY--VFT ADVPKMYRQILIHDD--DTKFQK-----V------LYREQ---S-SQ---------PL-K EIELTTVTYGTATAPFLATRV-LNQL------------A----EDE-QENF--P-KASKV V-KKS--FYVDDV-LSGAD-T---LDEAREIQQELL-AL-LARG-------GFGLH-KWC ANDA-EL-LQDIPIELREKQM------DFQ---------------------------NHD I----------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------TV ADPFSRAGVDYAGPVF-------------------------------------------- ----------------------------LK--QGRLRA---P-V------KG-YIV---L -FVCMC--TKAIHLELVTSMTTESF-----LAALQRF-VGRR-GNVHELYSDNGKNFVGA QRQLK-E-------LMKALNSQ-QL------------------KKGID---DFCQPRGIN ----WNFLPPKAPHQGGLWEAGVKCVKYHLHRVLN--E-----SNL----TYEEM----- --NTL-----LIQIEAVLNSRP--------LCQ------------Q-------------- ----------------------SD--------DPV--D-------Y-------------- ----------- >328/1-573 ----TMRGVLSTISSVFDPLNFAAPVIMRGKQIMQA-LWRR-K----------A------ -PWDE-P-LSG--DILRQWQTWKRELVRLE---D-LSIP--RCY--F------------- -SRPDHE--GVGL-QLHH-FSDASEA-GYG-SVSYLR--IEYP-DG------MVEC-A-- FVAG---------------------------KSRN-API--K-G---------------- --------------------------------STIPRLELQGAL-LAT-RVDQAVRRE-- -L------D-LKP---DRV---VF---------WT------------------------- -----------------------------------RTWYLPHFAV-------TNIN-K-P GKL-RIIFDAASE-Y-QG---TSLNKNLLHGPDCT--NSLTGVLLRFR---EDNV--ALV ADIEGMFLQVGVREE--DQDSLR-----F------LWW-D---KSSD---------DPPE EYAMNVHVFGATDSPCAANWT-LKKT------------T----TDN-AGDF--GDTTIET V-LHN--FYVDDV-LKSVD-T---SASAVTLANELT-EL-CGRG-------GFNLT-KFM SNSR-EV-LAEV-------PIEKRAAPTLDLD-----------------------L--DE -LPVE-----------------RA--LG-------------------------------- -----VRWNVETDTFGFKV----------------------------------------- ----------------------------------------------------------PY EPPFTYTGIDYFGPLY-------------------------------------------- ----------------------------VKRGRG-R-----V-TE-----KR-WGA---I -FVCMN--SRAVHLELAKSLETDDF-----ILALMRF-LNRR-GHVVELWSDNGSNFVGA DREIR-E-------HLEGMDQD-K----------------------IG---RECSAKGCK ----WIFNPPGATHMSGVWERMVRVVKRSLKAILG--K---N--PL----NDEVL----- --TTV-----FTEAERIANSRP--------LTR------------N-------------- ----------------------PE-------------NPDDEDPLTPNHF---------- ----------- >329/1-566 ----TKRVILSEIAKIFDPVGLVGPVGLHAKWIMQE-CWKE-K----------V------ -SWDE-S-VPQ--SLFTLWMDFASQLSSLS---S-VSAP--RHV--V------------- --CV-N-PS--RI-EIHG-FSDASKK-GYG-ACLYAR--STDK-DG------KITV-R-- LICS---------------------------KSRV-APL-------K------------- ---E----------------------------QTIPRLELCGAV-ILV-RLLLETLPA-- -L-E----F-S-I---DRI---VL---------WS------------------------- ---------------------------------------LPFLIV-------VKIL-SLT TKF-RVVFDASAKSS-LG---VSLNDLLYVGPTIQ--DKLYVHLVRFR---SHRY--VLT ADIEKMYRQILIHPD--DRRYQR-----I------FWYRD---G-KL------------Q VYELNTVTFGVSSAPYLAIRT-IHRL------------A----DDE-SAQY--P-RAAEI L-KRD--MYVDDL-LTGSD-S---LDEILKARDEII-TV-LKHG-------GFNIR-QWA SNHN-HA-LDNLDEKVLSLAP------DXE------------------------------ -DAVL-----------------KT--LG-------------------------------- -----VSWASKRDELAIVV----------------------------------------- ----------------------------------------------------------TE SHVFSHVGVDFFGPLS-------------------------------------------- ----------------------------IKEK--KRYN---RTTL-----KA-YGC---V -FVCMA--TKAVTIEITSDLTTEGF-----LGAFARF-VGRR-GIPQHVYSDNGTNFVGA NNQLR-E-------LFALLNSE-EF------------------KSKVN---AKALSLDIQ ----WHFNPPLSPHFGGLWEAAVKSFKHHLKRVVG--G-----QLL----TFEEL----- --YTL-----VIEIEAILNSRP--------LWS------------I-------------- ----------------------SA--------DPN--D-------PIALTPAHI------ ----------- >331/1-553 -----KRVVASEMAQLFDPLGLVGSVVMSAKMFIQK-LWAI-G----------I------ -PWDD-E-LPE--NLRDWWLRFRNEIPELS---R-LKVP--RQV--L------------- --AN----DHTSY-ALHC-FCDASNH-GYG-ACVYVV--STTG-TG------TYYS-Q-- LLIA---------------------------KSRV-APL-------R------------- ---G----------------------------LTTPKLELCAAV-LGC-QLLEQVRNT-- -T-N----F-A-----GSA---TF---------WS------------------------- -----------------------------------PQFILPHHAI-------FRPD-SST TKT-RVVFDATCKGS-SQ---LSLNDVLLVGPIVQ--PPLLAIVLNWR---IPRF--VFK ADVEKMFRQIWVHPS--DRRFQQ-----V------LWRTS---P-FQ---------EL-Q RYQLTTVTYGTSCAPYLATRV-LNQL------------A----EDE-GHRY--P-LGAKV V-LKG--FYMDDA-LSGED-D---LETAIESSKQLT-EL-LKLG-------GFNLR-KWS ANDP-RI-LAHMPDEVKELAP------ETE----------------------------ID DSGTI-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TP ARVFSNSGMDYCGPFS-------------------------------------------- ----------------------------VRPL--VGRG---ANV------KM-YVA---V -FVCMV--VKAVHLEVVSDLTSVAC-----INAVKRF-IARR-GRVVNLYCDNSTAFVGA DRELK-Q-------LRRQYVEQ-FS------------------TEQWN---GYCLESGIA ----FHFIPPRSPHHGGLWEAGVKSFKYHLRRVLG--S-----RSF----TLEEL----- --TTT-----VAQIESILNSRP--------LSS------------L-------------- ----------------------SN--------HPQ--D-------L-------------- ----------- >332/1-555 ----TKRIALSQIARLFDPLGLVGPVITSAKLFMQA-LWTL-K----------S-NEGHI WGWDQ-E-LPP--SYKERWLTYTSELPLLN---D-LRIE--RCI--L------------- --CS-N-PI--SI-QLHF-FSDASEN-AYG-ACCYIR--SCNS-VG------ETKT-A-- LLTA---------------------------KSKI-APL-------K------------- ---Q----------------------------QSIPRLELCGAL-LAA-ELYEKVAAS-- -L-K----I-T-----TET---YF---------WV------------------------- -------------------------------------------------------D-STT TKV-RVVFDASCRTP-EG---SSLNDALMVGPIVQ--EDLRSIIMRSR---THPI--MLI ADIKQMFRQIRVDEQ--DAPLQR-----I------VWRPS---S-DA---------PM-S TYELKTVTYGTASAPFLATRV-LRQL------------S----EDE-QDRF--P-EAAEV L-RMD--FYVDDL-FSGGN-T---VEETIALRRQLD-SL-LSAG-------GFELR-KWA SNVD-AV-LEDVPLDNKALKT--S-V-DLD---------------------------R-- -DQCI-----------------KS--LG-------------------------------- -----LHWEPATDHLRYKI----------------------------------------- ----------------------------------------------------------TA TRPFTITGIDYWGPIS-------------------------------------------- ----------------------------LKPI--HRRA---APG------KA-YVA---V -FVCFT--TKAVHLELVGDLSTAKF-----IQALRRF-VARR-GLCAEIFSDNGRNFIGA ANELR-Q-------M---IQSN-QH------------------QQAII---EECASNGIR ----WRFNPPKASHFGGLWEAAIQSAQKHFVRALG--T-----QTL----CIEDM----- --QTL-----LTQIECCLNSRP--------IVP------------L-------------- ----------------------SD--------DPS--D-------F-------------- ----------- >333/1-552 ---PTKRQVLRVVMSVFDPLGLVAAFVIHGKCLVQD-IWRT-K----------I------ -GWDE-P-IPT--ELHDTWRRWIQILQQLP---L-LKLP--RCY--F------------- -PNYNTD-SLQSL-QLHV-FVDASET-AYS-CVAYFR--IID--QG------KTRC-V-- LVSS---------------------------KTKV-APL--K-P---------------- --------------------------------MSIPRLELQAAV-IGT-RLMKSVQQS-- -H------T-LPI---CRR---VI---------WT------------------------- ---------------S---------------SDPRRVWYLPLGVV-------TNPN-K-P GKV-RVVWDAAAK-V-DG---ISFNSMLMKGPDLT--TSLTTVLYRFR---QRQI--AIA GDIKEMFHQIQIRPQ--DRQAQR-----F------LWRDG---T-GE---------P-LK EYVMDVATFGSTCSPSSAQFV-KNRN------------A----EEW-SCQY--P-EAAIA I-TES--HYADDY-LDSLD-S---EEEAVKLALDVK-TV-HAKA-------GFEIR-NWL SNSE-VV-IQRV--GD-PGYQ----IAKKFTV-----------------------G-KGT ET--E-----------------RV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PY VRAFTHIGIDYCGPFS-------------------------------------------- ----------------------------IR--VR-R-----Y-EV-----KK-WVM---L -VTCLT--VRAVHLEVVGSLSTEAC-----KMAIRRF-IARR-GSPLEIYSDQGTNFVGA SRELK-E-E------IAS-INR-D----------------------MA---GTFTNADTQ ----WRFNPPATPHMGGVWERLVRSVKTALRT-IS--S---G-RKP----DEETF----- --YTY-----LTEVESIVNSRP--------LTH------------V-------------- ----------------------PL-------------EH--------------------- ----------- >334/1-559 ----TKRIALSDAAKLFDPLGLLGPVIVVAKCFMQE-LWKN-E----------N------ -TWDE-P-LES--ERQQFWLRFREQLADLT---S-LTIP--RRA--I------------- --GGT---V--RI-EAHG-FSDASLR-AYG-ACIYIR--AESS-DG------QVSV-R-- LLCA---------------------------KSKV-API--P-NTKR------------- ---KKN--------------------------VSLPRLELSGAL-LLS-HLWQKVKQG-- -V-K----L---E---LKI---NF---------WV------------------------- -----------------------------------KTYYMPHHCV-------VRPD-SLT TKL-RVVFDASSSTD-TG---VSLNDALMVGPSVQ--DDLLSLLLRFR---VPRF--AIL ADIEKMYRQIWVKES--DRPLQR-----I------LWKES---A-DD---------RI-R IYQLKTVTYGTACAPYLATRC-LQAL------------A----KEG-ETRY--P-RASKV L-EQD--FYMDDM-ITGVE-S---VEDGRIICSEIN-QL-LQSA-------GFHLR-KWA SNSS-EL-LEQIPAELQIEGD--V-L-NID---------------------------R-- -STSI-----------------KA--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------NP VLPFYNTGVDLCGPLF-------------------------------------------- ----------------------------YRQT--NKKA---API------KC-YVA---V -FVCLV--IKAVHVELIADLSTPAF-----ISTLKRF-IARR-GKPSVIQCDNAKNFRGA DRALK-E-------MYELFQKQ-QH------------------QDAVT---TYCGTEGIT ----FNFIPPRSPHFGGIWEAAVKSLKRHLKATIG--S-----SIL----RRDDL----- --ETI-----LVQVEACLNSRP--------LTA------------L-------------- ----------------------SN--------DPE--D-------L-------------- ----------- >336/1-557 ---PTKRQVLRTLMMVFDPLGLIGHFMMLLKTLLQE-IWRS-S----------V------ -GWDD-M-IND--EHFEKWSTWCAVLPTIT---E-LLIP--RCY--R------------- -SLTSTS-EANII-QLHI-FVDASEA-GFA-AVAYLR--FNE--GS------IIEC-A-- LLGS---------------------------KTRV-SPL--K-F---------------- --------------------------------LSIPRSELQAAV-LGV-RLAETICNS-- -L------S-FKV---RQR---FF---------WT------------------------- -----------------------------------RIWYLPMFPV-------VNPN-K-P SKT-RLVWDAAAT-A-HG---ISLNSVLLKGPDQL--TSLLSVMIQFR---EYKI--AIC GDIREMYHQVQMRKD--DQQCQR-----F------FWKEN---S-TD---------AEPS TYIVQVMTFGACCSPSTAQYV-KNLH------------A----SKF-EQEN--P-VAAAV I-IKR--HYVDDM-LLSVE-Q---EDQAVQLTRDVK-QI-HASA-------GFEIR-NWA SNSS-AV-LEQL--NE---PSTA---EKSF-------------------------SED-S VV--E-----------------KI--LG-------------------------------- -----IWWNTSSDHFTFKI----------------------------------------- ----------------------------------------------------------AF SRPFTFMGVDYFGPMI-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WGV---L -ATCLT--IRAIHIELAHTLTTDSC-----ILALRNI-MARR-GTPAVIFSDRGTNFQGA SKELK-E-------ALQNIDQE-Q----------------------LI---KEFTTPNTE ----WSFIPPASPHMGGAWERLIRSVKTNLSKLQW------R-RSP----TDEVL----- --NST-----LIEIENVINSRP--------LTD------------I-------------- ----------------------PI-------------DD--------------------- ----------- >337/1-556 ---PTKRIVLRIVMSLFDPLGLLAPALIHGRILMQD-LWRS-G----------L------ -DWDA-E-LSD--SEHLKWQRWVNLLPGIE---R-LEIP--RWY--F------------- -SKTSVV-DYNSI-QLHV-FTDASEL-GYG-CAAYLR--MATA-SE-------INC-C-- LVMA---------------------------RSRV-APL--K-H---------------- --------------------------------LSIPRMELEAAL-LGA-RLMQAVSEN-- -L------E-LHI---RHK---FI---------HT------------------------- -------------------------------------WYLPINVV-------GHPR-K-P EKK-RLVWDAAAK-V-NG---VSLNSKLLKGPDLL--VQLPGVLCKFR---QRRV--AFG GDIEKMFHQIRIRKP--DTHSQR-----F------LFRFD---P-SE---------S-PK TYIMDVATFGATCSPCSAQYV-MHVN------------A----DQY-KETY--P-EAAAA I-KQK--TYMDDY-FDSCD-T---VEEANARARQVH-FI-HSKA-------GFNMR-NWM SNES-TA-LVGL--EK-----ANRIQHKAI-E-----------------------LEQKE QF--P-----------------RV--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------SH IRPFSAVGIDYLGPIE-------------------------------------------- ----------------------------VV--NA-R-----R-RE-----KR-YVA---V -FTCLV--TRALHLEVAHSLSTVAC-----IMAIRRF-VSRR-GPPTEIFSDNGTNFVGA NNELQ-K-Q------IAD-NKY-S----------------------LA---DTFTDAHTT ----WRFNPPSAPHMGGVWERMVRSVKEALNA-FD--D---R-GKL----NDEIL----- --LTV-----LADSESLINSRP--------LTY------------M----PQTLSDSEAL TPN----------------------------------HF--------------------- ----------- >338/1-562 ---PTKRQVLRTIMSLFDPLGLVAHFTIHGKIIMQQ-VWRT-G----------A------ -GWDD-V-ISG--EILEEWRRWSGLLKKIE---D-ARIP--RCF--F------------- -AD-TGA-HPKDA-EIHV-FVDASEN-AYA-CVAYLR--STLR-SG------VPRC-T-- LISA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAL-VGT-RLLDSICKA-- -L------T-IPV---VAR---YL---------WS------------------------- ---------------S---------------TESGRVWYLPLGVV-------RNPR-K-P EKV-RLIWDAAAR-V-KG---VSLNDRMLKGPDLL--TALPTVLLRFR---QKSI--AFS GDIREMFHQFLIRQR--DQQAQR-----F------VFRER---A-GQ---------A-PQ IFVMDVATFGAACSPCIAQYL-KNRN------------A----EEH-AEQF--P-NAAKA I-IEN--HYVDDY-LDSVD-T---VEEAVQLIQEVK-HV-HTLA-------GMEIR-NFS SNSA-EV-LERV--GE-VNKN----HHKSLSP-----------------------D-TI- -V--E-----------------RV--LG-------------------------------- -----MVWRPSEDVFSFEL----------------------------------------- ----------------------------------------------------------GF VRPFTHTGIDYFGPVY-------------------------------------------- ----------------------------VK--QG-R-----S-QV-----KR-WIA---L -FTCLS--VRAVHLEVVHCLSTQSC-----VMAIRRF-VARR-GSPITFCSDNGTNFVGA NNLLK-E-Q------LQK-ISK-D----------------------CA---QSFTNSQTK ----WLFNPPLAPHMGGSWERMVRSVKVAMAAIAH--H---P-RHP----SDEVL----- --ETI-----IVEAESIVNSRP--------LTY------------I-------------- ----------------------PL-------------DS--------------------- ----------- >339/1-532 ----TKRKVLSCIARIYDPLGIVDPVKAMAKQFLQR-IWTL-Q----------T-EQQQP WGWDD-E-LPH--HLQGEWINFHNQLIHLQ---N-LHIP--RVA--I------------- -RPDST-----SS-QFHF-FCDASEK-GYG-ACCYIR--SRDD-NG------NITM-Q-- LYAS---------------------------KTKV-TPI--N-S--K------------- --------------------------------HSIARLELCAAQ-LAS-LLYDRVRLA-- -VKL--------S---SPA---TF---------WT------------------------- -----------------------------------S-FYLPHHPV-------FKND-STT TKC-RVVFDASSKSS-TG---VSLNDTLMVGPTIQ--QDATSILLRFR---TQPX--ALT ADVTKMYRQVWIHPK--DRSLQR-----I------IWRSS---P-ND---------PI-Q EYELNTVTYGTASAPFLAVRS-LQQI------------V----ADH-GGEF--P-XAAE- R-SCD--FYVDDF-VSGGQ-S---SEAAQMLQLQTE-QL-YASA-------GFELR-KWA SSDP-SV-L--------------------------------------------------- ------------------------------------------------------------ ------------------------------QN---------------------------- ----------------------------------------------------------TP GRPFSITGIDYCGPVF-------------------------------------------- ----------------------------IKGP--HRRA---VAT------KA-YVA---I -FVCFT--TRAIHIELVSDLTTEAF-----LSALRRF-VARR-GLPEELHSDNATNFKGA NNQLN-E-------LYRLLRTP-EH------------------QQGMQ---SWTLERQIN ----WKFIPPRAPHFGGIWEAAVRSMKHHLVRVLG--N-----TTL----SFEDM----- --TTL-----LAEIECCLNSRP--------LTP------------M-------------- ----------------------TE--------DPS--D-------A-------------- ----------- >34/1-560 ----TKRILLSELAKIYDPLGLLAPTTVFLKVLFQD-SWLS-S----------V------ -EWNE-P-LPA--QLCARWQQFVAEVHLLE---S-CRIP--RYL--S------------- --SPLQ-----AT-ELHG-FADASSH-AYA-AVIYSR--VRFN-N-------DYAV-T-- LIAA---------------------------KTRV-API-------K------------- ---P----------------------------ISIPRLELNAAH-LLS-KLMSLVKQA-- -L-T----I-P-I---SST---SC---------WS------------------------- -------------------------------------NYLAHHAV-------FKPD-STT TKC-RVVFDGSGEDC-NG---SSLNSRLHIGPPIQ--RDLLGVCLRFR---QHRY--VFC TDIEKMFRGILVSED--HTHYQR-----I------VWRKE---E-TA---------TL-D HYRLLTVTYGLASSPFLAVRV-LKQI------------A----QDH-ADLY--P-KAAAV L-VRD--AYVDDI-PTGCD-S---IDDLIALKDELI-LL-LSQA-------QFKLR-KWS SNCW-SL-LKSLPQDM-CEYPLEALEGNSP------------------------------ -TQYV-----------------KV--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------QP TRCFLHSGLDYAGPVT-------------------------------------------- ----------------------------IKTS--AGRT---PKFG-----KA-WFA---I -FVCLS--TKAIHIELVSDLTTPAF-----IAAFKRF-WSRR-GPISDLYSDNGTTFHGA RKELT-E-------MQRIAVSQ-SQ------------------DEEIA---NFLTSQDIN ----WHFIPPSAPHFGGLWETGVRSIKLHLRRVIG--S-----SAL----TFEEY----- --STI-----LTQIEGLLNSRP--------LCA------------P-------------- ----------------------SD--------HS-----------LDPLTPAHF------ ----------- >341/1-562 ---PTKREVLSAIAKIFDPLGLISPVVVLAKILMQK-LWLA-K----------L------ -DWDD-Q-ISE--PLIEEWDNFLEALPTEN---Q-VRIP--RHV--V------------- --ST-N-AV--SL-EIHG-FADASLK-AYG-ACVYIR--SIER-NG------EAQL-R-- LVIS---------------------------KSRV-APL-------S------------- ---N----------------------------VTIPRMELLAAS-LLC-RLVKKVLEA-- -LKD----F-N-F---ETI---NL---------WS------------------------- ------------------------------DDGSVKRWYLPHHAV-------LNPA-KNT TKC-RVVFDASAKV--NG---LSLNDVMMTGPKVQ--HDLLSIKLRFR---MPRY--VVS ADISKMFRQIKVDPC--DSPLQR-----V------FWRAS---P-NE---------QL-R VLELTTVTYGTAAAPFLATRT-LLQL------------A----RDE-REGF--P-LASRI I-EEN--FYVDDG-LFGAN-D---IETVHAAQVQLI-EV-FRKA-------GMTLH-KWS ANDE-RL-LESIPFEDRDALT------KIG---------------------------DCE ANEII-----------------KT--LG-------------------------------- -----LMW---------------------------------------------------- ----------------------------------------------------------TA APTFQRVGLDFAGPIM-------------------------------------------- ----------------------------LK--SGIRRV---AAI------KG-YIC---V -FVCMV--TKAIHLEAVEDLSTGAF-----LSALRRF-VSRR-GIPEEIFSDNATNFVGA KNELR-E-------LYEMFRKE-AT------------------GQGIF---QFCQEKEIV ----WKMIPPGAPHFGGIWEAGVKSVKSVLKKIYK--S-----ASL----TITDF----- --STL-----LCQIEAILNSRP--------LYA------------H-------------- ----------------------SN--------D-----------------PNDL------ ----------- >342/1-541 ---HTRRGILSVVSSLYDPLGFLSPFIIPAKLLLQE-LCRM-N----------F------ -KWDE-P-VPC--DVSEHWSEWLSELQHMS---G-FKVE--RCI--K------------- -PKNFGT--QLKA-ELHH-FSDASQI-GYG-TVSYLR--LEST-DN-------VHV-S-- FITG---------------------------KARV-APL--K-Q---------------- --------------------------------LTIPRLELAAAV-LAV-RVNTMLLKE-- -L------Q-LPL---QRS---FF---------WT------------------------- ---------------T---------------LEQGKVWYIPHHGV-------HHPT-K-- GKL-RVVFDCGCT-Y-KG---TSLNSQLLQGPDFT--NTLIGVLLRFR---EEPI--AVM ADINAMFHQVRVPYK--HVNFLR-----F------LWWPN---GDTT---------AEPE EYRMCVHLFGAVSSPSCSNYA-LRRT------------A----EDN-ALQY--SPDVLRT V-KTN--FYVDDC-LKSTV-T---EEDAVKLIHGLT-SL-CKKG-------GFHLQ-KWV TNNS-NV-FALI-------PSNIRAVGLEN------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PD NAPFTNAGVDYFGPLE-------------------------------------------- ----------------------------VR--RG-R-----T-VL-----KR-YGV---I -FTCMS--SRAVHLEVAHSLDTDSC-----INAVRRF-ICRR-GPVTSIRSDNGTNFVGA KKELR-Q-------ALAALNHS-K----------------------IE---RTFVQEGMT ----WSFNTPAASHQGGVWERLIRSVRSVLTSVIG--H---Q--LL----DEEGL----- --QTL-----FCEVEAILNDRP--------ITK------------A-------------- ----------------------SE-------------D--------PNDL---------- ----------- >343/1-571 ----TRRELLSQVSGLYDPIGLTTPVKQKGAILVRR-AFQEAK----------PKCSTSK DTWDL-A-LSE--KLREDAISLFEEYAQLS---K-VKFH--RAL--T------------- -PAGAPAEPDAIT------FSDGSEH-AYG-AVLYLR--WACN-QG-------SMV-R-- LVES---------------------------KAKL-TPLDHK------------------ --------------------------------GEAVKSELCGAV-FAA-RLKKYFEQH-- --------GRIQV---KQW---YH---------FV------------------------- ---------------R---------------EWTGPVWYISHLIA-------PNPH-SVT TPV-RLVWNSSQK-C-RG---VSLNDLLLKGPDVL--NSIRAVLLKFR---RGGF--AAL GDVKKMYNSVWLEDQ--EVHLHR-----F------LWRDS---E-EE---------ELAE -YAVTRVNIGDKPAGCIAQLA-MRET------------A----NLP-QFSH--LEEERRV L-QED--SYVDDL-LTSHD-N---LDQLKVITGNVE-QI-LKAG-------GFELK-PWV FTGQ-SR-RESSGNDQ---AVTPRTVILPNQL--------------------------KE EDNKA-----------------LG--LG-------------------------------- -----YTL---------------------------------------------------- ----------------------------------------------------------RP AAPFEFTAVDLFGPYL-------------------------------------------- ----------------------------VKDDVKKRVRM-----------KV-WGV---V -FCCMA--SRAIHTELANTMSTESF-----LMAYQRF-TAIR-GHPKKIWSDPGTNFVGA KPVLE-E-------LYQFLDGL--------------------DRPAVE---ETSAQNGTS --WHWEIQPADSPHRNGSAEAAVRIVKKAFQSLGR--E-----SEL----SYSEL----- --QTT-----LQLAANLSNERP--------IDA------------R-------------- ----------------------VQS----------------------------------- ----------- >344/1-577 ----TKRSVLSESAKIFDPLGLIGPVVVQAKIFLQT-LWKQ-K----------C------ -DWDD-L-LPD--ELQSFWIEFRRNLLALD---T-LTVP--RWV--S------------- --FTKD-LV--TV-ELHG-FSDASNV-AYG-ACLYLR--CITV-DG------TITA-K-- LVTA---------------------------KSRV-ASL--E-DLKR------------- ---KKKV-------------------------LSTPRLELSAAL-LLS-HLYEKVCSS-- -I-K----I---P---FQS---FF---------WT------------------------- -----------------------------------PAYFLPHHAV-------LKPD-STT TKL-RVVFDASCRTS-TG---VSLNDGLMVGPVVQ--DDLHSISLRFR---FWKY--AIV ADVAKMYRMVNVCPT--DHPLQC-----I------LWRPS---P-DD---------SI-K AYKLTTVTYGTSSAPYLATKC-LQRL------------G----SDG-EATH--P-AAAKV V-KKD--FYVDDA-LTGTD-D---LEEGKALVSELI-DL-MSSA-------GFILR-KWS SNSA-EL-LGNVPIDLRDERS--S-F-ELD---------------------------S-- STSAV-----------------KT--LG-------------------------------- -----LIWEPAADIFRFTVPKL-------------------------------------- ----------------------------------------------------------NP AAVFLKVGVDLCGPFY-------------------------------------------- ----------------------------IKYP--VRRS---AAV------KC-FVA---I -FVCLA--TKAVHMEVVADLSTQAF-----LAAFKRF-VAVR-GKPQVVMCDNATNFVGA NRELE-E-------LRLQFLDQ-QF------------------QHTVV---RTVEDEGIQ ----FEFIPARSPNFGGLWEAAVKSFKGHFRKIVG--N-----QQL----SYDEL----- --HTI-----VQQVAAILNSRP--------LTP------------L-------------- ----------------------SN--------DPN--D-------Y-------------- ----------- >345/1-546 ---PTKREVLRVLMTIFDPLGLISHFLSYLKILLQQ-IWRS-G----------I------ -QWDE-E-IDD--DAYDKWLTWLKVLPRVE---Q-VKIP--RCY--N------------- -SKYLMS-ETDEV-QLHT-MVDASEN-GTA-AVCYLR--FIR--NA------SVSC-S-- IVAA---------------------------KSRV-APL--K-F---------------- --------------------------------TSIPRLELEAAV-VGA-RLSHSVQES-- -L------T-FKI---HRK---LY---------WS------------------------- -----------------------------------RRWYLPVFPV-------TNPN-K-P GKV-RIVWDAAAS-A-HG---TSLNSALLKGPDLL--CSLLTILLQFR---ERRI--GLT GDIREMFHQVLIRAE--DQFCQC-----F------YWLNQ---N-GE---------T--Q VYAMQVMTFGACCSPTTAQFV-KNIN------------A----DRF-ANDY--P-AAHQA I-TKS--HYVDDM-LVSLD-T---EEQAIQLAKDVR-HV-HQQG-------GFEIR-NWI SNSR-MV-LAAL--QG---ADTD---EKCLDL-----------------------SSE-L AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF SQPFTHVGIDYFGPIE-------------------------------------------- ----------------------------VT--VG-R-----R-VE-----KR-WIL---L -ATCLT--IRAIHLEVAHSLNTSSC-----IMALRNF-MARR-GTPQKVYSDRGTNFVGA NRELM-E-------INEVMNER-E----------------------FM---KEFGKAGIE ----WVFNPPLTPHMGGSWERLIRTVKNNLAVVCL------S-ARP----SDEVF----- --RNL-----LTEVENTVNSRP--------LSH------------V-------------- ----------------------PI-------------DD--------------------- ----------- >346/1-557 ----TKRIALSDASRLYDPLGLIGPTIMIAKCFMQN-LWAL-Q----------K------ -AWDE-P-LEK--ELHKQWNQFRQQLSIVK---D-MRIP--RRV--V------------- --GST---H--RI-EIHG-FSDASMK-AYG-ACLYMK--SVSE-DG------KVSV-N-- LLCS---------------------------KSRV-APL--A-NSKR------------- ---QKN--------------------------VTLPRLELSAAL-LLC-HLWQKVKDS-- -L-K----H---E---YSC---FY------------------------------------ -----------------------------------PIYYLPHHCI-------LRPD-SLT TKL-RVVFDASCATD-SG---LSLNDALMVGPVVQ--DDLVAIMIRFR---LPKF--AIV ADIEKMYRQVWIKKE--DRSLQR-----I------LWQNC---P-EN---------KL-R IYELKTITYGTASAPYLATKC-LQML------------S----VHG-TSTH--P-EASRV L-ANE--FYMDDL-LTGVE-T---QTEGEELCHQLT-DL-LSSA-------GFTLR-KWA SNSS-QI-LQSIPVDQRDTSG--L-C-SLD---------------------------I-- -NSSI-----------------KT--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TP TFPFLNTGVDFCGPLF-------------------------------------------- ----------------------------YRSA--SRKS---APV------KC-YVA---V -FVCLA--TKAIHLELVADLSSDAF-----ISTLKRF-VARR-GKPSLLQCDNAKNFRGA ERKLK-V-------FHQQLQQQ-QF------------------QQSIS---SYCGPEGIE ----FRFIPPRSPHFGGIWEAAVKSFKHHFRATIG--T-----SIL----RRDDL----- --ETI-----IAQVESCLNSRP--------LTP------------I-------------- ----------------------ST--------EPE--D-------L-------------- ----------- >347/1-569 ----TRRELLSQVSGVYDPVGLVTPAKQKGAILVRR-AFQEAK----------NTRLQVN ETWDV-A-LSD--DLREDAIKLFEEYIQLG---Q-IKFT--RAI--T------------- -PPEFEGHPWAIT------FSDGSEN-TYG-AVMYLR--WDSK-QG-------PVI-R-- LVES---------------------------KAKL-TPLDQK------------------ --------------------------------GDAIKAEVCGAV-FAS-RLRKYFEQH-- --------SRIQV---ERW---FH---------L-------------------------- ----------------------------------------------------PNPH-SVT TPV-RLVWNSSQR-F-RG---VSMNDLLIKGPDVL--NQIRAVLLRFR---SGVY--AAL GDIKKMYNSVWLEDQ--EVHLHR-----F------LWRDT---E-NE---------ELGE -YAITRVNIGDKPAGCIAQLA-MRET------------A----NLP-SFAH--LEEERRV I-QHD--SYVDDI-LTSHN-D---LDQLQSIVANTE-LI-LKAG-------GFHLK-PWV FSGQ-SG-REK--SDDKSCKIKEKVMVLPNQM--------------------------HD DDNKA-----------------LG--LG-------------------------------- -----YSV---------------------------------------------------- ----------------------------------------------------------QP AAPFEFTAVDLFGPYH-------------------------------------------- ----------------------------VKDDVKKRVLL-----------KV-WGV---V -FCCMS--SRAIHTELVNSQSTEGF-----LLAFQRF-AAIR-GYPRKIFSDPGTNFIGA RPVLQ-D-------LYQFLEGI--------------------DKSTLE---ETAVKHGTE --WIWKIHPADSPHRNGAAEAAVRIIKRALQNCGG--E-----STL----TYSEM----- --HTA-----LQIAANLANERP--------IDA------------R-------------- ----------------------AQTQEGCIQYVTPNSL---------------------- ----------- >348/1-605 ----TMRHIYRVLASQYDPLGYIIPYTTRAKILVQR-LWDK-K----------R------ -DWDD-PHLPE--DLLALWHEWEKELSGLE---E-ISLA--RCY--S------------- -LSEVDH-ASCKY-EIHI-FCDASEQ-AYG-SVAYLR--IEHK-EG------EVEV-A-- FVAA---------------------------RSRV-APR--K-Q---------------- --------------------------------QSIPRLELCAAL-SGA-QLSQLLNTE-- -L------T-VPI---HST---TL---------WS------------------------- ---------------A---------------DCSKESWYIPHHMV-------QHN----- NKN-RVVYNCSFQ-F-EG---HSLNDFLLPGPTLS--PSLLAVLLRFR---EHPV--AIS SDIRGMFHQVRLLPG--DMPLLR-----F------LW-RD---LKPD---------LPPD VYQWQVLPFGTTCSPCCASYA-LQTH------------V----INH-SQP---GDRFREV I-EKS--FYVDNC-LHSLH-S---PKEAKDLVDGLC-AL-LASG-------GFELR-QWA SNCP-SV-ITHL-------PPESRSSTCELWL-----------------------SQDQQ -DVHE-----------------ST--LG-------------------------------- -----LQWHCQTDTLRYKHRARSSAPVTMRHIYRVLASQYDPLGYIIPYTTRAKILVQRL ----------------------------------------------------------YF RPVFYSTGMDCFGPFV-------------------------------------------- ----------------------------IK--IG-R-----R-NE-----KR-WGI---V -FKCMT--TRAVHLDLLSSIDSDSF-----LMALRRF-IARR-GNPHELLCDQGTNFKGG ERELN-E-------AFAALQSE------------------------LQ---NHLAVQQIK ----FTYNPPSAPHFGGCWEREIRSIKAALKVTIG--A---Q--TV----TEEVL----- --RTV-----LIEVEGILNSKP--------LGY------------T-------------- ----------------------SS-------------DV--------------------- ----------- >349/1-549 ---TTRRGILSTVASIFDPLGFVAPFVLNGKRILQE-MCRQ-G----------T------ -GWDD-T-LYP--ALKPRWERWQNDLVNLE---N-VNIP--RCY--V------------- -PADFGK--VVKT-EMHH-FSDASTC-GYG-QCSYLR--MINE-DD------EIHC-S-- FLIG---------------------------KARV-SPL--K-I---------------- --------------------------------ITIPRLELTAAV-VSV-SMSNILREE-- -L------N-LID---VDE---FF---------WT------------------------- -------------------------------------WYIPHHGI-------YHPK-K-P DKL-RVVFDCSAK-F-KG---TSLNEHLLSGPDMI--NNLTGVLVRFR---RHPI--AVI CDIEKMFHQFHVQEK--DRDYLR-----F------LWWKD---GDTN---------SVLQ DYRMKVHLFGAVSSPGCANYG-LRYL------------A----NEY-SQSH--ALGA-QF I-TRD--FYVDDG-VTSAE-T---VEKAIQLTKEAR-EL-CAKG-------GLRLH-KFV SNDN-TV-LQSI-------PESERAVNFETKD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SPPFMYCGMDCFGPFM-------------------------------------------- ----------------------------TK--EG-R-----K-HH-----KR-YGL---L -LTCLC--SRAIHIEMLEDMSTDAF-----INSLRCF-IAIR-GTVRQIKCDQGTNFIGA KNELN-S-------ALQELDPE-R----------------------LT---TFLANKQCD ----FVLNAPHSSHAGGVWERQIKTVRSVLNATIT--L---SAGRL----NDASL----- --RTV-----FYEAMAVVNSRP--------LTI------------D-------------- ----------------------NL--------N----DPKSLEPLTPNHL---------- ----------- >35/1-562 ---PTKRTILSAIARLFDPMGWLSPIMITAKILMQQ-LWKE-K----------I------ -GWDS-T-LPD--TIKREWEKFVKELPNIV---T-IRIP--RHV---------------- ---TWG-LPGGVA-ELHL-FCDASSR-AYG-AAAYLR--FPIG-ED------KYHT-E-- LLLS---------------------------KGRV-SPT--KQQ---------------- --------------------------------LTIPRAELCAAL-EAA-KMYKYLKEN-- -L------R-ININY-SNT---IF---------WS------------------------- -----------------------------------IS--------------------SST TKV-RVVFDGSSKTS-NG---KSLNEILAIGPKLH--VHLQGIILNWR---GLKW--VFM ADVEKMYRCINIPPD--DAQYQR-----I------LWNPD---T-SD---------YV-E EYACTTVMFGTSSAPYLAMRV-MKQL------------A----MDE-CEKY--P-LAVDV I-NHQ--MYVDDI-LSGGD-S---IAETEDVKNQVI-GM-LRSG-------TFELR-KWA SNCT-KL-LENIPVEHRESSG----LLHME------------------------------ GNDTI-----------------RT--LG-------------------------------- -----LYWSPKEDEFRFALHVV-------------------------------------- ----------------------------------------------------------RP SRAFSSVGVDYAGPVN-------------------------------------------- ----------------------------ISPC--KGRG---RVSQ-----KG-YIA---V -FVCLV--TKAIHLEPVGDLTSDAF-----IGAFNRF-IGRR-GLCTDVYSDCGTNFIGA NKKLQVD-------KLAYCSYI-TK--------------------HIA---PTLLRKGIN ----WHFNPPSAPHFGGLWEAGVKSMKYHLKRTLG--E-----QVL----TFEEM----- --ATV-----LAQIESCLNSRP--------LCP------------L-------------- ----------------------SN--------DPD--D-------L-------------- ----------- >350/1-601 ---TTMRNIYRILASQYDPLGYLIPYTTRAKILVQQ-LWDK-K----------R------ -DWDD-PHLPT--DLLQTWTEWEAELPALQ---N-IVIP--RCY--C------------- -SANKDT-ETSLR-DMHV-FCDASER-AYG-SVAYLR--TEDQ-YG------QVEV-A-- FLTA---------------------------RSRV-APK--K-Q---------------- --------------------------------QSIPRLELCAAL-TGA-QLSKVLLTE-- -L------N-LPI---RHT---IL---------WT------------------------- -----------------------------------CSWYIPHHMV-------EHN----- GKN-RIVFNCSFQ-Y-HG---QNLNELLLPGPVLG--PSLLAVLLRFR---EHSV--AVS SDIKGMFHQVRLLPE--DKPLLR-----F------LW-RE---LNVQ---------EQPT VYEWQVLPFGTTCSPCCAIFA-LQKH------------I----LDH-SQP---GDDVQNS V-LKS--FYVDNC-LQSFT-S---AEAAKKFVDRIK-NQ-LADG-------GFELR-QWS SNIP-ST-INHL-------PPESISSSAELWI-----------------------SQGKS -DIQE-----------------ST--LG-------------------------------- -----LLWNHQSDTLSYKYRAKDSRETTMRNIYRILASQYDPLGYLIPYTTRAKILVQQL ----------------------------------------------------------LF KPAFHSTGMDCFGPYT-------------------------------------------- ----------------------------VK--TG-R-----R-NE-----KK-WGI---I -FKCLT--TRAVYIDILHSLETDSF-----LMALRRF-TARR-GKPQELLSDQGTNFRGG ERELK-E-------AFTALAPD------------------------LQ---SQLAKQQIE ----FHFNPPNSPHFGGCWEREIRSLKNALMVTLG--N---Q--SV----TFEVL----- --QTV-----LAEIEGILNSKP--------LGY------------T-------------- ----------------------SS-------------DA--------------------- ----------- >351/1-539 ---FTRRGVLSTIASIFDPLGFIAPYILVGKRTLQR-MCND-K----------I------ -GWDE-P-LPD--DLRLHWEAWLRDLHNLS---M-VKIP--CCY--M------------- -PSTFKD--VQQY-ELHH-FADASVS-GYG-VCSYLR--MVTK-SG------EVHC-S-- LAMG---------------------------KARV-APA--K-V---------------- --------------------------------TTIPRLELTAAV-VAT-RIGNLLKGE-- -L------E-LDC---VRE---YY---------WT------------------------- ---------------E---------------LGNQPAWYIPHHGV-------YNPQ-K-P GKI-RVVFDCSAR-F-QN---TSLNDNLLTGPDLT--NTLVGVLSRFR---KGKI--AIM CDVERMFHQFYVAPK--DRDYLR-----F------LWWEE---GKMA---------CPPS VFRMKVHLFGAASSPGCANFG-LKFL------------A----SQG-KGKF--NQATVKF I-QRN--FYVDDG-LVSVD-T---EAEAIQLVKEAR-EL-CNTG-------KLHLH-KFI TNNK-RV-ITTI------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ET TAPFTYSGMDCFGPFY-------------------------------------------- ----------------------------VK--EG-R-----R-EL-----KR-YGL---L -FTCMC--SRAIHLEVLDDLSTDAF-----INALRCF-IAIR-GNVSKLYSDQGTNFVGA KREFV-E-------LMKGMNEE-R----------------------VK---EL----GCT ----FSMNPPASSHMGGVWERQIRSVRSVLTSILD--Q---AANRL----DTTSL----- --RTF-----MYEVMAIVNSRP--------LTS------------E-------------- ----------------------HI--------N----DPTGPEPLTPNHI---------- ----------- >352/1-551 ----TMRKIYRTLAKLYDPLGYLIPYTTRAKTVVQL-LWDK-K----------R------ -EWDD-PNLPE--DLLAIWHQWENELPNLS---Q-VFLP--RCY--T------------- -SH-IQC-TVKHR-CVHV-FCDASER-AYG-SVAYLC--SEDE-QD------NRHV-S-- FIAA---------------------------RSRV-APR--K-Q---------------- --------------------------------ISIPRLELCAAL-TGA-QLGDVLKRE-- -L------T-LNI---NQF---VY---------WS------------------------- ---------------S---------------ESSAKSWYIPHHMV-------QHN----- GKN-RIVFNCSFE-Y-KG---QSLNEYLLPGPTLG--SSLLGVLLRFR---EYPV--AIC SDVKGMFHQVRLLDE--DKPFLR-----F------LW-RQ---GKTS---------EMPV VHQWEVLPFGTACSPCCAVFA-LQSH------------V----KGD-LDP---TDEVRQT V-ERN--FYVDNC-LSSVP-T---ESQAKNLVNRLQ-CH-LMDG-------GFELR-QWA CNIP-EV-IQHL-------PNDLKSKSGEIWL-----------------------SQG-- ------------------------------------------------------------ ----------------------------------------------I------------- ----------------------------------------------------------LF KPPFYSTGVDCFGPLM-------------------------------------------- ----------------------------VK--IG-R-----R-IE-----KR-WGI---I -YKCLT--TRAVHLDLLYHMDSDSF-----LMSLRRF-IARR-GKPHELLSDQGTNFKGG ANELE-D-------TFNQIQPI------------------------LR---DMLAKDQIR ----FQFNPPSAPHFGGSWEREVRSVKTALRSTLG--A---Q--TV----TEEVL----- --RTI-----LTEVENILNSRP--------LGY------------V-------------- ----------------------SS-------------DIADPDPVTPNSL---------- ----------- >353/1-565 ----TRRGILSVVSSIYDPLGFLSPFILLAKALVQS-LCRM-K----------L------ -TWDE-E-IPE--DVANRWFAWLSDLSQFA---S-FSVR--RCV--K------------- -PEGFGP--LTSA-QLHH-FSDASEK-GYG-VVTYLR--IQNS-HG------RVHC-S-- FLLG---------------------------KSRV-TPL--K-P---------------- --------------------------------VTVPRLELTAAT-VAV-KMDKLMRRE-- -L------R-MDL---KES---VL---------WT------------------------- ---------------K---------------RNDGRVWYIPHHGV-------AHPQ-K-- GKL-RVVFDCAAS-F-QG---KSLNDELLQGPDLT--NSLVGVLTRFR---HKHI--ALI SDIEAMYHQVRVHDE--DSDLLR-----F------LWWPQ---GDLS---------QPLH EYKMVVHLFGAKSSPSCANYA-LRRT------------A----EDG-KGSS--SPEAVTT V-LEH--FYVDDC-LVSTS-D---ENKAKTLTKELI-AL-CESG-------GFRLT-KWS SNSRCEV-LSSL-------PEQERAKEIKNLD-----------------------LD--- ------------------------------------------------------------ --------------------------------------YPWKGPWTGAR----------- ----------------------------------------------------------PD HPPFTNVGVDYFGPFE-------------------------------------------- ----------------------------AK--RG-R-----V-QV-----KR-YGV---L -FTCLT--VRAVHLEIAHSLDTDSC-----INAMRRF-IARR-GQVEVMRSDNGTNLVAT EHEIR-Q-------AMKEWNKS-Q----------------------IS---EALLQRGVT ----WIFNPPAGSHHGGIWERQIRTVRKILTNLLK--L---Q--SL----DDECL----- --QTV-----MCEVEAVINSRP--------LTK------------S-------------- ----------------------SD-------------DVDDLEPLTPNHL---------- ----------- >354/1-542 ---PTKREVLRVLMTIFDPLGFIAHFLIYLKVLLQE-IWRS-G----------V------ -QWDD-E-INN--NLLEKWKTWLRILPAVE---Q-VQIP--RCY--R------------- -SKLTTE-SD--V-QLHT-FVDASET-AFA-AVSFLR--FTS--GE------QVEC-L-- IVAS---------------------------KTRV-APL--K-F---------------- --------------------------------QSIPRLELQAAV-LGI-RLAQSITEA-- -L------S-IRF---KKR---YF---------WS------------------------- -----------------------------------RSWYLPVFPV-------VNIN-K-P GKT-RIVWDAAAT-S-YG---VSLNSALLKGPDQL--CSLFEILLQFR---KYRI--GIT GDIREMFHQVQIREE--DRACQR-----F------FWNNE---D-GT---------T--A VYEMCVMTFGACCSPSTAQYV-KNMN------------A----DRF-SEQY--P-QAVEA I-TKQ--HYVDDM-LTSVE-S---EEDAIQLAQDVK-YV-HSQG-------GFEIR-NWI SNSE-AV-IKTL--GE---CEAT---KKCLDL-----------------------SAE-M SV--D-----------------KV--LG-------------------------------- -----LWW---------------------------------------------------- ----------------------------------------------------------AF TRPFTHVGIDYFGPLE-------------------------------------------- ----------------------------VA--IA-R-----R-VE-----KR-WGM---L -ATCMT--TRAVHIEIVHTLSTNSC-----VMAIRNM-MARR-GIPNHIYCDRGTNFVGT NSELT-R-------ISEQLSNE-A----------------------IL---NEIISPDTK ----WSFNPPSSPHMGGCWERLIRSVKRNLTSLSL------P-RKP----SDEVL----- --RNA-----LTEIENTLNSRP--------LTH------------V-------------- ----------------------AV------------------------------------ ----------- >355/1-568 ---PTKRSILSQIASLFDPLGLLAPVIVKAKLVMQR-MWEL-K----------V------ -AWDS-T-PPG--ELSKDWFDLVQSFPLLN---T-FQIP--RRI--I------------- --DMRN-WS--RL-YLHG-YCDASEV-AMG-ACLYVR--AIDD-EG------NTSS-H-- LLCA---------------------------KSKL-API--G-NGR-------------- --------------------------------VTTPRLELCAAV-ILA-RLMANVQAA-- -L-S----T-TTF---YEI---RA---------YS------------------------- ------------------------------------SVYLPHHCV-------IKAT-SST TKC-RVVFDASAKTT-SG---LSLNDALMCGPVVQ--DSLINILIRFR---FPAV--VLV GDAKQMYRMIWLDEV--DRDFQR-----I------LWRWN---V-DE---------PV-R EYRLNTVTFGTKSASYLATKC-VHEL------------L----ESN-RERY--P-MAVER A-IKG--IYVDDV-LIGAS-S---EEEAKTLREQLT-EI-FAAG-------GFHLR-KWA SNSA-GV-LDGVPDSDLELKI------SIE----------------------------EG GSSTV-----------------KT--LG-------------------------------- -----MQW---------------------------------------------------- ----------------------------------------------------------KP SPPFSVTGVDYAGPVS-------------------------------------------- ----------------------------VVGR--RSRG---AVPS-----KG-YIA---L -FVCFG--TKAVHLEAVSDLSASSF-----LAAFSRF-VSRY-GLPSKMYSDNATNLRSA AKTLR-Q-------LYRQIDVA-EH------------------SSDVC---DYLADKRVQ ----WSFIPARSPHHGGLWEAGIKVVKGFLNKIGN--N-----YNY----TFEEL----- --STL-----LAQISACMNSRP--------ICA------------I-------------- ----------------------SD--------DPK--D-------PQPLTPAHF------ ----------- >356/1-552 ---PTKRQVLQVVMSIFDPLGLVAAFVIQGKCLIQD-IWRA-G----------V------ -GWDD-Y-IPN--DLLPHWRRWVDVLQNLN---Q-VRIP--RCY--F------------- -PGYDPR-SIGSL-ELHV-FVDASET-AYA-CAAYFR--IVD--RG------QVRC-A-- LVSA---------------------------KTKV-APL--N-P---------------- --------------------------------MSVPRLELQAAV-IGV-RLMESVQSN-- -H------S-LPI---KRR---VL---------WG------------------------- ---------------D---------------SDPRRVWYLPLGVV-------QTPS-K-P GKV-RVVWDAAAK-T-GG---VSLNSMLLKGPDLL--TSLPSVLFRFR---ERQV--AIT GDIKEMFHQILIRPE--DRQSQR-----F------LWREN---S-ED---------P-IQ EFVMDVATFGSTCSPCSAQYI-KNKN------------A----EEW-KNVY--P-EAAAA I-VEN--TYVDDY-ANSSD-T---VEEAVRIALEVK-EI-HASA-------GFEIR-NWL SNSP-QV-LQRV--GE-QSLQ----VTKSFIA-----------------------E-KST ES--E-----------------RI--LG-------------------------------- -----MAW---------------------------------------------------- ----------------------------------------------------------PY VRPFTXIGIDYCXPFL-------------------------------------------- ----------------------------IR--IG-R-----S-NV-----KR-WVV---L -ITCLT--IXAVHLXVACSLSTESC-----KMAIRRF-IARR-GAPLEIYSDQGTNFVGA SKELR-T-E------STA-VNR-A----------------------LA---GXFTNRETQ ----WRFNPPAAPHMGGVWERMVRTVKNSLET-LS--T---N-RTP----DEETF----- --QTL-----LIEVEGIINSRP--------LTF------------V-------------- ----------------------PL-------------GT--------------------- ----------- >357/1-546 ---PTKREVLKVVMSLFDPLGLVSHFLVHGKVIIQG-TWAA-G----------T------ -GWDE-P-INE--DLNRKWRQWVSLFPKLN---E-LKIS--RCY--F------------- --SQLPS-SIKNL-QVHT-FVDASDI-AYS-CAVYFR--LVH--GD------CVQI-A-- LVGA---------------------------KSKV-APL--K-T---------------- --------------------------------LSTPRLELKAAV-LGV-RFAAAILEY-- -H------S-LPV---SQR---FF---------WS------------------------- -------------------------------------WFLPLGVV-------VHPR-K-P NKI-RLVWDAAAM-V-DG---VSFNSKLLKGPDLL--TPLPAVLSRFR---QFPV--AIC GDIKEMFHQLSIREQ--DRLAQC-----F------LWRDS---P-MK---------P-VQ IYVMDVATFGATCSPASAQYV-KNIN------------A----EEF-SEDY--P-RAATA I-VKN--HYVDDY-LDSFQ-T---VDEAADVVKEVA-WV-HSLG-------GFEIR-GFR SNST-GL-LRKI--GGP----SAADVPKNLML-----------------------E-RSA TS--E-----------------SV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PY VRPFTYVGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-QA-----KR-WIA---L -FTCLS--VRAVHMEIVHSLSTESC-----IMAVRRF-ISRR-GSPAVIYSDNGTCFQGA NKQLT-E-E------IAA-RNE-A----------------------MA---HTFTNTDTK ----WKFIPPATPHMGGVWERLVRSVKTAIGLALE--Y---P-RKP----NDETL----- --ETI-----IYEAEALVNSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >358/1-563 ----TKRVVVSDVSRLFDPLGLVGPVIIQAKIFIQE-LWRQ-S----------S------ -EWDE-P-LSP--ELQAQWQEYRRNLTGLE---N-LTVP--RWV--G------------- --TGGH-IV--TT-ELHG-FCDASNK-AYG-ACFYIR--TISE-TG------EVCV-R-- LLTA---------------------------KSRV-APL--D-NLKK------------- ---GNKR-------------------------LSTPRLELSSAL-LLA-HLLEKVVSS-- -I-G----I---A---MRC---FF---------WT------------------------- ------------------------------RR-----YYLPHHAV-------LKPD-STT TKL-RVVFDASCQTS-TG---VSLNDALMVGPVVQ--DDLSSICLRFR---THRI--AVN ADIAKMYRMIRVQPQ--DYPLQS-----I------KWRHE---P-SE---------PL-R TYELTTVTYGTSSAPYLATKC-LQRL------------A----EDG-ESSH--P-VASKV I-KKD--FYVDDM-LTGID-T---VEEGQQLVKEII-DL-SDSA-------GFTLR-KWN SNSR-EL-LEVVPEKLRDERT--I-L-TLD---------------------------S-- SEATI-----------------KT--LG-------------------------------- -----LAW---------------------------------------------------- ----------------------------------------------------------TP CTPFQRVGVDYCGPFQ-------------------------------------------- ----------------------------VAYP--HRRN---RPV------KI-FIA---V -YVCLV--TKAVHLELASDLSAQGF-----IATLKRF-TSRR-GKPEIIMCDNGRNFVGA RRQLD-E-------LCRLFNDQ-NF------------------QSSVS---RQANEEQIE ----FRFIPARSPNFGGLWESAVKSFKLLFKRTIG--L-----RTL----LYDEM----- --NTV-----LTQAEAVLNSRP--------LTP------------L-------------- ----------------------SN--------DPD--D-------F-------------- ----------- >36/1-562 ---YSRRTILSAIASLYDPVGLIAPIIVSAKTLMQQ-LWLL-N----------V------ -SWDD-P-LPE--HIVQKWQQFYDSLRHLQ---N-LRID--RWT--F------------- -GCL-Q-PI--AV-EIHG-FSDASMV-AYG-ACIYVK--TVDV-SG------NAYV-R-- LLCA---------------------------KSRV-APL-------K------------- ---K----------------------------VTLPRLELCAAV-LLS-ELLTKVLDS-- -V-E----L-S-V---DSC---FL---------WT------------------------- -----------------------------------N--YLPHHAV-------LKPT-STT TKL-RTVFDASSKTS-SG---FSLNDIMMTGPNIQ--ADQFSLLLGFR---CWRY--VVT DDIAKMYRQIRVDQQ--SSNLQR-----I------LWRET---P-SQ---------PL-K VYQLNTVTYGTRAAPFLAVRT-LHQL------------A----ADE-KDTY--P-NACRS H-CKR--FYVDDL-LHGSN-S---KQALLKTRDELL-AV-LHKG-------SFELR-KWS SNDP-EL-LKDLPEGLVEKGTMCE-ID--D------------------------------ -DEIV-----------------KS--LG-------------------------------- -----LSW---------------------------------------------------- ----------------------------------------------------------QP ARPFIKTGVDFAGPIT-------------------------------------------- ----------------------------IRSSL-LRKA---PKL------KA-YIA---V -FVCMS--TKAIHLELVGDLTTQSF-----LAALRRF-VGRR-GMVAEFFSDNATNFVGA NSELR-E-------LKRMFESN---------------------GEHFS---KKLAEAGII ----WHFIPPRSPNFGGLWEAGVKSVKNLLKKTCG--A-----MVF----TYEEL----- --NTL-----LVQIESILNSRP--------LAP------------V-------------- ----------------------SD--------DIE--D-------LMPLTPAHF------ ----------- >360/1-543 ---PTKREVLRVVMSLFDPLGLVSHFLVHGKVIIQG-TWAA-G----------T------ -GWDE-P-LNE--ELLKKWRQWVSLFPKLN---D-LKIS--RCY--F------------- --SPYPS-NIGDI-QMHT-FVDASDI-AYS-CVIYFR--LVH--LG------HVQV-V-- LVGA---------------------------KSKV-APL--K-T---------------- --------------------------------LSTPRLELKAAV-LGV-RYAAAISEY-- -H------S-IPL---TRR---FF---------WS------------------------- -------------------------------------WYLPLGVV-------VNPK-K-P NKI-RLVWDAAAM-V-DG---VSFNSKLLKGPDLL--TPLPAVLCGFR---QYPI--AVC GDIKEMFHQLLIREQ--DRLAQC-----F------LWRNT---T-TE---------P-IQ VYVMDVATFGATCSPAAAQHV-KNRN------------A----EEF-AEVY--P-RAATA I-VKK--HYVDDY-LDSFT-T---IEEAAAVVKEVA-MV-HSLG-------GFEIR-GFR SNST-AL-LREI--GDS----TAAD-PKN-ML-----------------------E-RN- ST--E-----------------SV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PF VRPFTYVGVDYFGPLY-------------------------------------------- ----------------------------VK--VG-R-----S-QA-----KR-WVA---L -FTCLS--IRAVHMEIVYSLSTESC-----VMAIRRF-VSRR-GSPAVFFSDNGTCFQGA SKQLK-E-E------ANT-RIE-A----------------------IA---DTFTDAETK ----WKFIPPAAPHMGGVWERLVRSVKTALGTALE--H---P-RKP----NDETL----- --GTI-----IQEAEALVNSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >361/1-559 ---PTKRDVLRTLMAIFDPLGLIAHYLMYLKVLLQE-IWRA-K----------T------ -EWDE-K-INE--KHLEKWLTWLRILPELE---S-VEIP--RCY--F------------- -RHESRI-DNATV-ELHT-FVDASEN-GYA-AVSYFR--FEM--NG------YIEC-A-- LIGS---------------------------KTRV-API--K-F---------------- --------------------------------VSIPRLELQAAV-VGA-RFAKSIAEG-- -H------S-IRI---DRR---YF---------WT------------------------- -----------------------------------RTWYLPIFPV-------FNPN-K-P GKV-RIVFDAAAE-F-AG---VSLNSVLMKGPDQL--NALPPVLYKFR---ERLI--GLG GDVAEMFHQMRMNPE--DADSQR-----I------LWFAS---E-DA---------TKPC DYVMQVVTFGATCSPSTALYV-LNEN------------A----TKY-ETRY--P-LAVDA I-CRR--HYVDDM-LTSVD-T---EEEAIELANEVR-YI-HHQG-------GFHMR-NWV SNSP-AV-VAAL--EE---DPKS---EKSMEM-----------------------NAE-L AM--E-----------------KV--LG-------------------------------- -----MWWSTTADVLCYKL----------------------------------------- ----------------------------------------------------------AF VRPFSYVGVDFFGPLH-------------------------------------------- ----------------------------VL--VG-R-----R-HE-----KR-WGV---I -VTCLT--TRAIHLELAASLNTSSC-----IMALKNC-FARR-GTPLEIRSDRGTNFVAA EKELK-A-------ALQELNQD-R----------------------LM---TEFTTPTTS ----WRFNPPASPHMGGCWERLIQSVKKILAVVKP------Q-RVP----TEEVL----- --RSY-----LMQVENIVNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >362/1-536 ---YTRRGVLSTINSLFDPFGFAAPVVIQGRLLLRT-LTTE-S----------C------ -DWDA-P-LSS--EKFKEWKIWRDSLKKLE---L-VKIP--RTY--A------------- -TISLHQ--AQRR-EMCV-FCDASTN-AIA-AVAYSK--ITSI-SG------NVEV-G-- FIFG---------------------------KVKL-APR--P-E---------------- --------------------------------ISVPRLELCAAV-LAV-EIAEIIADE-- -I------D-IKL---DVV---TF---------YS------------------------- -------------------------------------WYLPMFGV-------YHPK-K-P GQI-RVVFDSSAQ-H-QG---VSLNDVLLTGPNAN--NSLLGVLLRFR---KERV--AVM ADIQQMFHSFVVAKE--HRNFLR-----F------LWYAN---SDLN---------SEVR EYRMRVHVFGNSPSPAVAIYG-LRRA------------A----LTG-EQDY--GFEARHF V-ERN--FYVDDG-LTSFP-T---EEEAIKLLKDTQ-EM-LAQS-------NLHLH-KIA SNKV-EV-MKAF-------PSEDLAKEL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SI DPPFSFVGVDIFGPWM-------------------------------------------- ----------------------------VT--SR-RTRGGQA-NS-----KR-WAV---L -FTCMS--TRAIHIEVIESMDSSSF-----INALRRF-FAVR-GPAKQLRSDCGTNFVGA CKELK-M-------EAI-TDDR-K----------------------VQ---EYLSNKSCI ----WIFNPPHSSHMGGSWERMIGVSRRILESMLQ--GI--APSKL----SHEVL----- --ITF-----MAEVTAIVNNRP--------L--------------V-------------- ----------------------PV-------------ST--------------------- ----------- >363/1-574 ---FTKRGVLSVINSLYDPLGFAVPVSIEGRSILRE-ISTD-I----------S------ -EWDT-P-LPK--EKQERWQKWKDSLKHLQ---H-LKIP--RMY--T------------- -CIPLSE--AQRK-EVHI-FCDASTK-AVG-AVAYLK--LIDI-NG------KSEV-G-- FLLG---------------------------KARL-APK--P-D---------------- --------------------------------ITIPRLELCAAV-LAV-EVAELIQGE-- -L------D-TIM---HEV---NF---------YT------------------------- -----------------------------------ECWYLPHFGI-------YHPQ-K-P GKI-RIVFDSSAE-C-EN---VSLNQVLLKGPDLN--SSLVGVLLRFR---SDLY--AVM ADVEQMFHNFRVRED--HRNYLR-----F------LWFHD---HNLD---------GQVE EFHMTVHVFGNCPSPSVAIYG-LKRT------------A----EEG-EEEY--GSDVREF I-ERH--FYVDDG-LKSFT-S---ETQAIDVLRRTQ-KM-LAQS-------NIRLH-KIS SNSP-VV-TSAF-------PHEDLATGLQGLD-----------------------LGQHP -PPMQ-----------------HS--LG-------------------------------- -----LGWDL-------------------------------------------------- ----------------------------------------------------------NT DPPFTCVGLDIFGPWT-------------------------------------------- ----------------------------VT--TR-KTRGGQA-ES-----KR-WAV---I -FVCMS--TRAIHIEVIESMDTSSF-----INSLRRF-FALR-GAAKLLRSDCGTNFVSA CRELQ-I-------SKLGCHNK-E----------------------IN---NYLEDSGCQ ----WLFNPPHASHMAGSWERMIGVSRRILDAMLL--HH--GNAKL----THEVL----- --VTF-----MAEVTAIVNARP--------L--------------T-------------- ----------------------AV-------------STDPEHPEILTPAML-------- ----------- >364/1-561 ----TRRGVLSTISSIYDPLGIVSPVVLSAKKILQE-LCRK-N----------L------ -GWDD-A-LPD--VFAQRWTSWLQELHYLE---C-FEVA--RCL--K------------- -PPDFGD--IVKA-QLHH-FSDASEE-GYG-TVSYLL--LHNE-HF------QSHC-T-- FIMG---------------------------KSRV-APM--K-C---------------- --------------------------------VTIPRMELIAAT-MAS-RMDVLWKKE-- -L------H-LQL---QDS---VF---------WT------------------------- ---------------T---------------RGDGKIWYLPHHGV-------YHPT-K-- NKI-RVVFDCGAG-F-QQ---ASLNAQLLQGPDLT--SSLVGVVTRFR---KEPI--VIT ADVESMFHQVKVPAD--DVDLLR-----F------LWWPD---GDLG---------RDPV DFRMLVHLFGATSSPSCANFA-LRKC------------A----EDH-KEQF--SKETVEA V-LHS--FYVDDC-LVSVA-S---VEQAKTLYQELV-SI-CAKG-------GFKLT-KWI SNSL-QV-LDAI-------PEAERSKSMKDLR-----------------------MDWDS -PSVE-----------------KV--LG-------------------------------- -----VQW---------------------------------------------------- ----------------------------------------------------------PN EPPFTRVGVDYFGPFN-------------------------------------------- ----------------------------VK--SR-R-----S-VV-----KR-YGV---I -FTCLA--IRAVHIEVAPSLDTDSF-----INALRRF-IARR-GQVQEIRSDNGRNFVGA EQELR-V-------AIKEWNQC-K----------------------IN---NVLLQKGIK ----WTFNPPTGSHYGGVWERLIRSVRKILNSTLK--S---Q--NL----DEEGL----- --QTV-----LCEVEAIINSRP--------ITK------------A-------------- ----------------------ST-------------D--------QTDLEA-------- ----------- >365/1-544 ---WTKRRILSQIAKIFDPIGFASALLVKAKIGMQR-LWQL-G----------L------ -DWDE-E-LPS--REKAEWVKLFREMENLD---G-VSFQ--RCL--T------------- -PPGAMR----RP-TLCV-FCDASEE-AFG-ACVYIR--WELE-DG------SYDV-R-- FVTA---------------------------KSRV-APL--K-K---------------- --------------------------------LTLPRLELQAAV-VAV-RLDATIRDE-- -T------T-LEL---RET---VF---------MT------------------------- ---------------K---------------RHDGPVHYIGHHAV-------VRPE-KKS TPV-RIVFNSSAV-F-KG---QCLNDYWFKGPDLL--QSLFGVLLRFR---EHRV--AIC ADISKMYHRVLIPES--DQHVHR-----Y------LWRGL---D-SE---------REPD VYVKTVVTFGDKPAAAMAQIA-LRRT------------A----VEG-ESQH--PKAA-EV L-KRD--TYMDDI-CTSVR-T---SEEAKDLVKDID-EV-LADG-------GFKVK-GWQ SNEQ-LK--D----ETSQMKTN---------V---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF SPPFLYTSCDYFGPYS-------------------------------------------- ----------------------------VK--VG-R-----NKVA-----KH-YGV---I -FTCLN--TRAVHLDLAVDVSTMEF-----LQVLRRF-FAFR-GQPKVILSDNGTQFVGA VRELR-E-------MVKGWDSD-L----------------------LR---EFCAEKGVE ----WRFTTPSAPHQNGCAEALVKSSKSALKKAIG--D-----QVL----TPFEL----- --YTC-----LVEVANLVNQRP--------IGR------------V-------------- ----------------------PN-------------DPDDGSYLCPNDV---------- ----------- >366/1-528 ---PTKREIARVVMSLFDPLGFIAFFLVHGKILLQD-VWAT-G----------T------ -EWDQ-R-IPN--DINNRWQQWSHLFEQLH---Q-LRVP--RCY--F------------- -RAPFAS-SLNGL-QIHL-FVDASEA-AYS-CVAYFR--LDT--DN------GTQV-A-- LVGA---------------------------KTKV-APL--K-T---------------- --------------------------------LSIPRLELKAAV-LGV-RFLETIQNH-- -H------E-FTI---HSR---YC---------WS------------------------- ---------------S---------------VDAGRVWYLPLGVV-------RNPK-K-P GKI-RLIWDAAAK-V-GN---VSFNSKLLKGPDLL--SPLPKVLSQFR---QFPV--AVC GDIMEMFHQIKIRAP--DNQSQR-----F------LFRDS---P-SE---------Y-PS VYVMDVATFGATCSPASAQYI-KNLN------------A----EEC-SKDY--P-RAAAA V-KNK--HYVDDY-LDSFE-T---LQEAIAVVNEVK-LV-HSVG-------GFTLR-NFS SNKS-EV-LDGI--GA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF VRPFTFTGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NA-----KR-WVA---L -FTCLT--TRAIHLEVVHTLSTESC-----IMAVQRF-VSRR-GIPREFWTDNATCFQGI SNELQ-I-I------SEA-TKK-A----------------------MA---EKFTSPQTT ----WKFIPPATPHMGGAWERLVRSVKVAIRAIID--G---P-RRP----DDETL----- --ETV-----LLEAEAMINARP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >367/1-570 ----TKRQMVSKILRLYDPIGLVQPVIVTAKIQMQQ-LWKH-R----------L------ -NWDD-E-IPS--DVIKEWKEFESSLAELQ---R-IEFP--RMT--I------------- -PSKTI-----VL-DLHG-FSDASGK-AYG-CVIYLH--AIDL-QG------NEST-N-- LLCS---------------------------KSRV-APL-------K----YEEPPRSAT SSTK----------------------------ATIPRLELQAAL-LLS-ELSARIKGI-- -L------G-KRI---TSE---HY---------YS------------------------- --------------------------------------FIPHSCV-------IKPD-STS TKL-RVVFDASAKTS-SG---VSLNDIQVIGPTIQ--KELFDQLIEFK---THDK--VLM GDITKMYRQVQVAEE--DTWLQC-----I------LWRNQ---S-CE---------PI-E AFRLTTVTYGEAASSFLACRA-LHAA------------G----EDY-REID--P-EIADL I-QKS--FYVDNL-MIGAA-S---TEELQRMKKGIQ-DA-LLRH-------GFPLR-KWA SNDA-ST-LEGTPPEDLEPLI------------------------------------QMG DQEVI-----------------KT--LG-------------------------------- -----VAW---------------------------------------------------- ----------------------------------------------------------NQ SAAFSHTGVDLCGPFE-------------------------------------------- ----------------------------VLLN--QRSK---CKI------IA-YAC---I -FVCFT--TKAVHLEVVEDQSASAF-----ISALLRF-TSMR-GVPEVIYSDNGRNFVGA SRELN-R-------LRKAYNNQ-NF------------------QNKII---DTAAKSGIH ----FSFIPPRSPNFGGLWESNIKVAKRLFSAAAR--G-----AQL----NIMEL----- --QTL-----FYQVAAIMNSRP--------LTA------------V-------------- ----------------------YAGTEAPTPLTPG--H-------F-------------- ----------- >368/1-559 ----TKRRIMSYIAQIFDPLGLVGPVIVVAKLFMQR-LWAL-K----------T-EKGDP YEWDR-P-LPA--HLQKEWKTFHGMLDAIA---T-LRIP--RCV--C------------- --LA-N-PT--SF-QFHF-FCDASQK-AYG-ACCYVR--TES--AG------AVRI-R-- LLTS---------------------------KSKV-APL-------A------------- ---HP---------------------------QIIARLELCGAV-LAS-NLYKKVIQS-- -I-P----K-S-----AQV---YL---------WT------------------------- -------------------------------------------------------S-STT TKV-RVVFDASCKTS-SG---FSVNDLQLVGPVVQ--EDLLSIHLRFR---SHQI--ALV ADVEKMYRQILVHPS--FRRYQL-----I------LWRPD---P-SL---------PI-A TYELQTVTYGMASAPFLATRT-VVKI------------A----EDS-TERY--P-AAAPK A-KKD--FYVDDC-LTGAE-D---VESAIRVRQEMS-DM-LSSA-------GLPLK-KWA SNSP-EA-LANVPAEDLALAP--Y-Y-DLQ---------------------------D-- -AQSV-----------------ST--LG-------------------------------- -----LIWEPRSDMMSFKV----------------------------------------- ----------------------------------------------------------TP TRAFTVCGVDYCGPVY-------------------------------------------- ----------------------------IKSP--VRNR---APT------KA-YIA---I -FVCFA--TRAVHIELVSDLSTPAF-----LAALRRF-VARR-GRMREIHSDNGTAFKGA ANELR-R-------IYEMLKSN-EAD-----------------RKQIL---DWCAQNEIV ----WRFIPPRAPHFGGLWEAAVKSAKNHLLREIG--T-----VNV----AYEDM----- --CTL-----LTQVEMCLNSRP--------LVP------------I-------------- ----------------------PT--------EPS--D-------L-------------- ----------- >37/1-547 ---PTKREVLQVLMSIFDPLGFLSCHTIGLKILLQR-IWRL-N----------I------ -DWDQ-E-LPE--KILEDWRLWKTLLGQIR---I-FEVP--RCF--S------------- -PDTSDP---RQT-ELHT-FVDASEY-AYS-AVCYLR--VAM--DA------KVDV-S-- LVIA---------------------------KSKV-APL--K-P---------------- --------------------------------LSIPRMELQAAV-MGA-RLAHKVMST-- -R------N-LRI---DNA---TY---------WS------------------------- -----------------------------------RTWYLPIFIA-------RNPN-K-P SKL-RLVWDAAAK-S-HG---CALNDYLLKGPDCL--NPLIEVLLAFR---VNKI--AIC GDIAEMFHRINIREE--DMHAQR-----F------LWYDR---SS-----------DKVE TYVMRAMTFGISCAPFIAHFV-RDKN------------A----EAH-QEDF--P-LALNA I-QKA--HYVDDY-IDSMR-N---EQEAIQTTRQVI-EV-HRRG-------GFEIR-NWS SNSK-EV-LKSL--QS----------NGNVGS-----------------------QEPVD FCSTE-----------------K------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------SF QRPFTYTGVDYFGPLL-------------------------------------------- ----------------------------VN--VG-R-----R-KE-----KR-WVA---L -FTCLT--LRAVHFEIAYSLDTSSC-----IMCLSNF-MALR-GTPKEIFSDNGTNFRAT EKAVR-E-------ELKKIEHD-K----------------------IT---IKF--DGIK ----WRFNPPGAPHMGGAWERLVRTTKGILKNICP------N-YSF----NDEGL----- --RNA-----LMEAQFIINSRP--------LTF------------V-------------- ----------------------SL-------------DTEDDAALTPNHL---------- ----------- >370/1-552 ---PTKRQVLRVVMSYFDPLGIISNYTIHGRILLQD-IWRS-K----------A------ -NWDD-P-ITN--EDFVSWQRWVLLAPQLT---K-VKIP--RCY--F------------- -PAYDPN-SFETL-QLHV-FVDAGDQ-AYG-AVAYFR--IVD--RG------IPRC-A-- LVAA---------------------------KAKV-APL--K-P---------------- --------------------------------LSTPRSELNASV-IGI-RLMKMIEKN-- -H------S-FTI---NKR---FL---------WT------------------------- ---------------N---------------SNPKRTWYLPLGVV-------RNPR-K-P DKV-RVVWDAAAK-V-NG---ISLNSLLLPGPDLL--TPLLTVLCQFR---QRQY--AVS ADIRQMFHQLLIKPE--DRQVQR-----F------LYRSD---S-RS---------T-PT VYVLDVATFGATCSPCSAQYA-KNLN------------A----FQH-MDTF--P-DAAEA I-VKN--TYVDDY-LDSRD-T---IDEAVQLSLDVR-AI-NQKA-------GFELR-NWQ SNSK-EI-LRRI--GE-KCHD----SVKNFAA-----------------------E-KST PT--E-----------------RV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PY IRPFSFVGLDYFGPML-------------------------------------------- ----------------------------VK--RG-R-----T-NV-----KR-WVA---L -FTCLT--VRAVHLEVVHSLSTESC-----KMAIRRF-IARR-GAPREIFSDNGTNFRGA ARELA-E-E------IKN-INA-E----------------------VA---VTFTNVDTK ----WTFTPPSAPHMGGVWERKVRSIKEAFKS-LC--H---R-DKL----DDEEF----- --STF-----LMEAEMIVNSHP--------LTF------------V-------------- ----------------------PL-------------DE--------------------- ----------- >371/1-552 ---PTKRIVARSIMSVFDPTGMLAPFSIHGKMLIQD-LWRS-G----------T------ -QWDQ-D-IPD--EEYAKWMRWTHLLPGIG---R-LKIP--RYY--F------------- -GTLSPN-RFKSL-QLHV-FTDASEF-AMG-CAAYFR--AADD-QG-------VHC-A-- LIMS---------------------------KSKV-APL--Q-H---------------- --------------------------------QSIPRLELQAAV-MGA-RMLKCAMEN-- -H------N-LPI---SRS---FL---------WT------------------------- ---------------S---------------ADPNRVWYLPINVE-------AHPR-K-P GKK-RLVWDAAAQ-V-DG---MSLTSQLLKGPDLL--NSLPSVISVFR---ERPI--AFG GDVREMFHQVRIIPK--DKHSQR-----F------VFRFD---P-SD---------P-PD IYIMDVATFGASCSPCSVQHV-MRKN------------A----LEH-AADF--P-DAAAA I-IER--TYMDDY-VDSTD-T---VEEAATRAKQVR-EI-HAQA-------GFEMR-NWV SNSE-DV-LRAL--GE-----IKEQKPVPI-G-----------------------DVTQE NW--E-----------------RV--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------PY IRPFCYVGVDYLGPLE-------------------------------------------- ----------------------------VA--VG-R-----R-KE-----KR-YVV---V -FTCLV--VRAVHLEIAYDLSTDSC-----VMAIRRF-VRKR-GSPEQIFSDNGTNFVGA NRELT-Q-Q------IKL-IND-N----------------------CA---NTFTDAKTK ----WSFNPPAGPHMGGVWERMVRSVKESMRA-LD--D---G-RKL----NDEIL----- --LTV-----LAETEWFINSRP--------LTY------------M----PQ-------- -------------------------------------EA--------------------- ----------- >372/1-555 ---NTKRQMLSDSARLFDPLGWVAPIIVRIKILFQS-LWLQ-D----------L------ -LWDD-P-LPA--AIDDEWNKIKNDLQAIE---K-IRIP--R-W--I------------- -PHHGGK--V----QLFG-FADASEA-AYA-AVVYAR--STDQ-NG------KIFV-S-- LVAS---------------------------KTKV-API--Q-Q---------------- --------------------------------VSLPRLELNAAV-LLT-DLMKQLMQS-- -L------S-HLD---VTC---YA------------------------------------ ---------------------------------------FPHHAV-------LRSE-SLT TKL-RVVFDGSCETA-TG---VSLNDRLLVGPKVT--EDVPVVFTRFR---TYVV--AFT ADVEKMYRQVKVRKE--DTNYQR-----I------IWSPE---P-GK---------PF-E HYRLLTVTYGSSCAPYLAIES-LRQA------------A----RDC-QSQY--P-EAAEH V-SKN--FYVDDL-LSGAN-T---LEEAIKLRNDII-QV-TSTA-------GFTLR-KWS SNDP-RL-FD-ESTETDAAVPLHLFAPDAD------------------------------ ---SV-----------------KA--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------VG RRAFENVGVDYAGPIV-------------------------------------------- ----------------------------LKAS--VLRT---TKTI-----KG-YIA---V -FVCLG--TKAIHLEAVTDLSSGAF-----ISALKRF-CSRR-GLPSQIWSDNGTNFVGA DHQLK-D-------LLQSVNFN-S---------------------EIN---RYLSGLGVK ----WTFITPSAPHMGGIWESAVKSMKKHLRIVLG--K-----QMI----TYEDM----- --TTI-----LTQIEACLNSRP--------LCA------------L-------------- ----------------------SS--------STD--S-------CEALTPGHF------ ----------- >373/1-545 ---PTKREVLRTLMSIFDPLGLLSNVLVHLKILFQE-IWRS-A----------I------ -NWDD-E-IPD--NLDEKWEQWLRIIPQLE---N-ISIP--RCY--R------------- -SLTTIG-ADTNV-QLHT-FVDASEM-GYA-AVVYLR--FQQ--GN------SVEC-A-- IVGA---------------------------KSRV-APL--K-F---------------- --------------------------------VSIPRLELQSAV-LGS-RLANTITEA-- -L------S-FSI---NER---VF---------WT------------------------- -----------------------------------RFWYVPIFPV-------FNXN-K-P GKL-RIVWDCAAK-T-GN---VSLNSMLIKGPDQL--VPLNNVLYRFR---EYKI--XIS GDIREMFLXVKIAKE--DQNCQL-----F------LWXDX---P-DD---------EAPS TFVSQVXTFGACCSPSSAQFI-KNLN------------A----XKF-VEXF--P-RAVEA I-TKQ--HYVDDM-LASVE-S---EEEAIXLAEDVR-XI-HANA-------GFEIR-NWI SNSS-TV-LQAL--HQ---XKTE---XKSLHF-----------------------GSD-S ST--A-----------------EK--VL-------------------------------- -----GMWW--------------------------------------------------- ----------------------------------------------------------AY TKPFSYVGVDYFGPMI-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WGV---L -ITCLT--IRAVHLEVANSLSADSC-----IMALRAF-MARR-GVPLQIYSDRGTNFIAA SKELN-D-------ALKDMDQQ-K----------------------VI---QEITTQHTQ ----WTFLPPSSPHMGGAWERLIQTVKRNLQAMLP------X-RAP----TDEVL----- --RNT-----LTEIENLINSRP--------LTH------------V-------------- ------------------------------------------------------------ ----------- >374/1-522 ---PTKRQVLRVVMSYFDPLGIVATYTVHGKILIQD-VWRS-G----------V------ -KWDD-K-IAA--EDYENWQRWVKLAPNLR---E-VRIP--RCY--F------------- -PNYNPG-SYDSL-ELHV-FVDASLT-AYC-AAAYFR--IFD--ND------APRC-A-- LVAA---------------------------KTKV-TPL--K-P---------------- --------------------------------QSIPRNELCAGV-IGV-RLLKSIQEN-- -H------S-IPV---QKR---YI---------WT------------------------- -------------------------------------WYLPLGVV-------QHPR-K-P GKV-RIVWDAAAR-V-GE---TSLNSMLLAGPDLL--TPLLKVMCGFR---QRQY--AAV GDVRQMFHQLLVKPS--DRQAQR-----F------LFRSD---P-TH---------H-PT IYVMDVVIFGASCSPCLAQHV-KNTN------------A----RDY-EELY--P-DAASA I-INN--TYVDDF-LDSRD-T---VDEAVRIVEEVR-WI-FDKA-------GFEIR-NWQ SNSE-EL-LRRV--GVDV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY VRPFTFTGLDYFGPLI-------------------------------------------- ----------------------------IK--RR-R-----S-NE-----KR-WVA---L -FTCLT--VRAVHVEVVHTLSAESC-----KMAMRRF-ISRR-GTPQQIYSDNGTNFRGA ARELA-D-E------TRI-INR-E----------------------LA---TSFTNAEIE ----WVFNPPSAPHMGGVWERKVRSIKDALKS-LH--H---D-QHL----NDEEL----- --TTF-----LAEAEMIVNSHP--------LTF------------V-------------- ----------------------PL-------------ED--------------------- ----------- >375/1-543 ---PTKRQVLRCVMTLFDPLGLLSPFVIHGKVLIQD-LWRE-G----------T------ -EWDE-Q-ISD--DVNEKWKRWVRMIVYIA---E-IRIP--RCY--F------------- -HKATKE-TYQKS-EYHV-FVDASGE-AYC-CAIYLR--TINE-RG------EPQC-R-- LVAA---------------------------KSKV-API--K-P---------------- --------------------------------WSIPKLELQGCV-LGV-RWSKFVKEN-- -H------S-LPV---SKM---VF---------WC------------------------- -------------------------------------WYLPVGAV-------INKK-K-P GKV-RVIWDAAAK-V-EG---VSLNSQLLKGPDQL--SSLPAVLFRFR---QYGV--AVS SDIQEMFHQIRIREQ--DKHSQR-----F------LWRTN---P-SD---------V-PT IYLMDVATFGSTCSPASAQFV-KNLN------------A----EQH-RERY--P-EAASA I-IDD--HYVDDY-LASFG-S---EKEAAKVARDVR-YV-HGNG-------GFKLH-NWR SNST-RV-LEQL--DEV----QPKA-DKLLNL-----------------------V-DGG KS--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------HH ERAFTYTGVDYFGPLL-------------------------------------------- ----------------------------VK--LG-R-----S-NV-----KR-WIA---L -FTCLT--VRAVHLEVAYTMSTESC-----ISCVRRF-VXRR-GPPAEFXSDNGTNFQGA DRVLR-H-Q----------ISQ-G----------------------LS---NTFTSTNTR ----WNFIPPGAPHMGGAWERLVRSVKAAMAEA-Y--S---E-GKL----DDEGL----- --QTL-----VVEAESXVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >376/1-562 -----KRQVLSVIATLFDPLGLLGAVITTAKTIMQL-LWKF-R----------N-ERDQA LDWDQ-P-LPS--TVGEIWRAYYDQLPLLN---D-VRID--RCV--T------------- --IP-E-AI--KI-EIHC-FSDASTK-AYG-GCVYVR--SQDG-QG------GLKV-R-- LLSS---------------------------KSKI-APL-------K------------- ---T----------------------------QTIPRLELCGAL-LTA-QLYEKIRDS-- -I-R----T-D-----AQA---FF---------WV------------------------- ------------------------------SD---KRCYLPHHPV-------IKEA-STT TKL-RVVFDASCKTS-SG---VSLNDSLLVGPIVQ--EDLRSIMLRSR---MKQV--MLV ADVEKMFRQIFILPE--DRHLQC-----I------LWRFD---S-AD---------PV-D VYELNTVTYGTKSAPFLATRT-LNQL------------A----MDE-EHQY--P-LAAKA A-TED--TYMDDV-ITGAD-T---IQAACELRVQLE-EM-TMKG-------GFRLR-KWA SNNP-TV-LEGISEDNLAIRLSEG-I-DLD---------------------------P-- -DSTV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TP SRPFSQTGVDYFGPMY-------------------------------------------- ----------------------------IRPA--PRKP---A-I------KV-YVA---I -FVCLC--TKAVHLELVMDLTTDRF-----LLALRRF-VARR-GKCQDIYSDNGTNFVGA RNRMK-D-------FLQLLKSP-NH------------------REKVS---KECNEDGIR ----WHFSPPSSPHFGGLWEAAVRSAKNHLLKVMG--E-----SCP----SAEEL----- --NTL-----LVQVEGCLNSRP--------LTP------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >377/1-595 ---PTKRQALSVVMSTFDPLGFLAFFLIHGKILIQE-LWRA-K----------I------ -QWDQ-L-LPE--KLSEQWTRWIAYFQCLD---Q-ISIP--RCY--F------------- -PRHSVK-DILSL-QLQI-FVDASEE-AFA-CVAYLR--AEFS-NG-------IEI-A-- LVAG---------------------------KSKV-APL--K-A---------------- --------------------------------LSIPRLELMAAV-IGA-RLRQTIIER-- -H------S-LQI---DRT---YL---------WS------------------------- ---------------E---------------ADPRRVWYLPLGVA-------LNPK-K-P SKV-RIFCDAAAK-V-DG---ISLNSLLLKGPDLL--NNLFEVLFGFR---EKRI--AVC ADLKEMFHQIQIRKE--DRHAQR-----L------LWRDD---P-TK---------S-PE VYLMDVATFGATCSPCSAQFV-KNLN------------A----AEH-AKEY--P-VAAVA I-QRK--HYVDDY-LDSAD-S---VEEAVKIAEEVR-HV-HSQG-------GFHLR-NWL SNSK-EV-LLRV--GE-NDPA----SEKNIQL-----------------------D-KGS ST--E-----------------RV--LG-------------------------------- -----LFWRPDKDDFTFSTNSTRHVEQPTKRQALSVVMSTFDPLGFLAFFL--------- ----------------------------------------------------------AF ERPFSYVGVDYFGPIA-------------------------------------------- ----------------------------VR--VN-R-----G-SC-----KR-WVA---L -FTCLT--VRAVHLEIVHSLTTESC-----KMAFRRF-IARR-GAPVEIYSDRGTNFVGS SNELQ-R-E------MCV-IEQ-Q----------------------LV---ETFTNTNTR ----WIFNPPAAPHMGGAWERLVRSVKTALAA-MY--T---T-RIP----NEETL----- --ETL-----VAEAEGVVNSRP--------LTF------------I-------------- ----------------------PL-------------EK--------------------- ----------- >379/1-543 ---PTKRQVLRCVMSLFDPLGLLAMYTVHGKILIQS-IWRS-E----------K------ -DWDE-K-IGD--EEFRRWMKWISVLNQID---G-IRLP--RCY--I------------- -GRTVSS-AISSV-QLHL-FVDASEE-AYA-AAAYFR--FTLV-DG------TVMC-N-- LIAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-LGT-RLASFIGDN-- -H------T-ISI---EKR---FF---------WS------------------------- -------------------------------------WYLPIGVV-------TNPK-K-P GKV-RLIWDAAAK-V-DG---ISLNSVLLKGPDLL--CPLPGVLFRFR---ERPI--AIS GDIREMFHQLRIRLE--DRHAQR-----F------LMREN---P-SR---------E-PD IYLMDVATFGSSCSPCSAQFV-KNRN------------A----EDF-AQDY--P-RAVEG I-TKC--HYVDDY-LDSFD-T---FEDAQRVAAEVK-MI-HTKG-------GFEIR-GWR SNSP-EV-LMHL--GET----TAQT-TKDLQL-----------------------D-NHG DM--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------SF ERPFSYVGVDFFGPIL-------------------------------------------- ----------------------------VK--VG-R-----S-HA-----KR-WVA---L -FTCLT--IRAVHLEVAYSLSTESC-----ITCFRRF-VARR-GAPLEVYSDNGTNFQGA EKQLR-E-Q----------ISN-G----------------------LA---DTFTNANTK ----WFFNPPSAPHMGGAWERMVRSVKVAIENI-D--S---G-RKL----HDEGL----- --LTL-----LAEAESMVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >380/1-586 ---PTKREMLRVLMTIFDPLGLVAHFLIFLKILLQE-VWRS-K----------I------ -QWDE-K-ITG--DLYRKWVLWTSVLPQVE---T-VRIP--RCY--S------------- -SSMVVN-SCTDI-QLHT-FVDASEN-GFA-AIAFLR--FDC--NG------TTKC-S-- IVAS---------------------------KARV-APL--K-F---------------- --------------------------------ISIPRLELQGAV-LGA-RLSQTIITS-- -L------S-LRI---TRR---VY---------WT------------------------- -----------------------------------RIWYLPIFPV-------TNPN-K-P GKT-RLVWDAAAK-T-FG---VSLNSALLKGPDLL--CSLLTILLQFR---QGRF--GIS GDIREMFHQILMRTE--DQQCQR-----F------FWTDK---D-GE---------L--A VYVLQVMSFGASCSPCCAQFV-KNLN------------A----ERF-HTSH--P-TAVEA I-TKR--HYVDDM-LASVD-E---ENEAIRLAEEVK-YV-HSQG-------GFEIR-NWM CNSK-AV-LMAL--QQ---RDVV---EKDMDL-----------------------SSE-M AV--E-----------------KV--LG-------------------------------- -----MWWSTETDEFMFKVGWNRYDSLLLTGQRPPTKREMLRVLMTIF------------ ----------------------------------------------------------AF QHPFTYAGVDYFGPME-------------------------------------------- ----------------------------VV--VG-R-----R-VE-----KR-WGM---L -ITCLT--VRAIHIELVHSLSTNSC-----IMGLRNF-ISRR-GSPRRIYSDRGTNFIGA SRELS-E-------AIAAINQS-A----------------------MI---DEFVSPDTE ----WVFNPPAAPHMGGCWERLIRTVKKNLMAIRP------T-SRL----TDEEL----- --RNT-----LVEIENTVNGRP--------LTH------------V-------------- ----------------------PI-------------DS--------------------- ----------- >381/1-552 ---PTKRNLLRCVMSIFDPLGLMSHFLIHGRVIIQD-VWRT-H----------T------ -GWDE-V-VSA--EIQEKWRRWTAGFAELS---R-VRIS--RSY--F------------- -PGFLST-EIREL-QLHI-FTDASED-AYA-CVAYLR--AEI--DN------EVYC-A-- LVMA---------------------------KAKV-APL--K-A---------------- --------------------------------LSIPRLELQGAL-LGT-RMLRTIVDS-- -H------T-LPI---VRQ---VL---------WT------------------------- ---------------S---------------ADPERIWYLPLGAV-------RNAR-K-P GKI-RLVWDAAAK-V-KG---ISFNSMILKGPDLL--TPLLTVLFGFR---ERKV--AIC GDLKQMFHQFRILAN--DTQSQR-----F------LYRKD---P-TQ---------P-IQ VYTMDVGTFGSTCSPCQAQYI-KNLN------------A----EEH-KDTF--P-RAASA I-VFK--HYVDDY-LDSFD-T---EEEAIDVALEVK-QV-HANG-------GFTIR-NWL SNST-TV-LRRV--GD-SGNQ----ESKQIEA-----------------------N-KEK TT--E-----------------RV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------QC GRPFTYIGLDYFGPIA-------------------------------------------- ----------------------------VK--RG-R-----S-LV-----KR-WIA---L -FTCLS--VRAIHLEVVHSLSTESC-----KMAIRRF-VAMR-GAPSEIYTDNGTNFQGA SRELH-Q-E------LHE-INN-G----------------------LA---DTFTDANTK ----WFFNPPAAPHFGGVWERLVRTVKVALAS-LT--S---L-NNP----DDETL----- --LTV-----IAEASAIVNSRP--------LTF------------I-------------- ----------------------PL-------------QS--------------------- ----------- >382/1-525 ---PTKREVLRVVMSVFDPIGLVAVFVVHGKVLVQH-IWRS-G----------L------ -GWDE-R-IPA--TLLEQWKRWIKLLQQLD---Y-VEIP--RCY--F------------- -PGYSPE-DYRAV-ELHI-FVDASEE-AFA-AVAYFR--IVE--GS------RVRC-S-- LVSA---------------------------KTKV-APL--K-L---------------- --------------------------------LSIPRLELSAAV-LGA-RLSKTVAEN-- -H------T-IPI---SRK---VF---------WS------------------------- ---------------S---------------FNPKRTWYLPLNVV-------TNPR-K-P NKV-RLVWDAAAK-V-QG---QSFNSALLAGPDLL--APLPAVLSSFR---QFEV--AIS ADICEMFHQITIRPE--DRSAQL-----F------LWRDD---P-SK---------P-FD VFVMDVATFGSTCSPSAAQYV-KNRN------------A----EEF-AEQF--P-RAAEA I-TKH--HYVDDF-LCSVH-T---EHEAVELAEQVR-LV-HSKA-------GFTIR-NWL SNSS-NV-LTRV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SH VRPFTYVGLDYFGPML-------------------------------------------- ----------------------------VK--QG-R-----N-EV-----KR-WVA---L -FTCLT--IRAVHLEVVHNLTTESC-----KMAVRRF-IARR-GAPKEIFSDRGTNFVGA SRDLK-E-E------IQR-ITT-N----------------------LA---STFTNTDTQ ----WRLNPPYTPHMGGSWERMVRSVKSALAS-LS--T---S-GKP----DDETL----- --RTL-----LIEAESIVNSRP--------LTY------------L-------------- ----------------------PI-------------DS--------------------- ----------- >383/1-547 ---PTKREVLKVVMSLFDPLGFVAFFLVHGKVLMQD-VWAA-G----------I------ -DWDE-K-ISE--ELYFRWRQWTYYFPQLD---N-LRIP--RCY--F------------- -QSPFPA-NLDRL-ELHV-FVDASDS-AYA-CVAYYR--LET--AN------GVQV-A-- LISA---------------------------KTKV-APL--K-V---------------- --------------------------------LSIPRLELKAAI-LGV-RLLENIHGY-- -H------T-YPI---SRR---VL---------WS------------------------- -------------------------------------WFLPLGVV-------VNPK-K-P EKI-RLIWDAAAK-V-GG---VSFNSYLLKGPDLL--TSLPRVLSGFR---LFPV--AIS GDIREMFLQIRLQAS--DRNAQM-----F------MFRNS---S-RD---------P-VQ IYAVDVTMFGSTCSPSSAQFV-KNLN------------A----EQY-SSEY--P-RAATA I-KEH--HYVDDY-LDSFR-T---VEEAVQTLNDVK-HV-HARA-------GFEIR-NFL SNKS-EV-LKRT--GEI----EPDS-SKEFAL-----------------------V-RAE TT--E-----------------SV--LG-------------------------------- -----MKW---------------------------------------------------- ----------------------------------------------------------PL VRPFTYVGLDYFGPIL-------------------------------------------- ----------------------------VK--VG-R-----R-QA-----KR-WVA---L -FTCLT--IRAVHLEVVHSLSTESC-----IMAVRRF-IARR-GAPAEFYTDNGTCFQGA NKQME-REI------MEA-RSN-A----------------------LA---ATFTSAGTQ ----WRFIPPAAPHMGGAWERLVRSVKAALASVAA--A---S-RTP----DDEVL----- --ETV-----LLEAEMLINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >384/1-552 ---PTKREVLRVVMSVFDPLGFIATYTIHGKILIQD-IWRS-G----------I------ -GWDE-R-ILP--RDFANWQRWIKLSSELS---N-VSIS--RCY--F------------- -PNYAPE-SLEST-ELVV-FTDASEM-AYC-CVAYFR--IMD--RG------VLRC-A-- LVSA---------------------------KSKV-TPL--K-P---------------- --------------------------------QSIPRNELNAAV-MGV-RLANVINES-- -H------T-LPI---TKR---TF---------LT------------------------- ---------------S---------------ADPRRVWYLPLGIV-------RNPR-K-P GKV-RVVWDAAAK-V-KD---VSLNSMLLKGPDLL--VSLPSVICRFR---QRKF--AVA GDVKQMFHQLQIRKE--DRHSQR-----F------LYRAD---P-AD---------P-PA IYIMDVATFGAACSPCSAQYA-KNLN------------A----TEY-QNTF--P-EAATA I-IEN--TYVDDF-LDSRD-T---ADEAAQLVIDVR-EV-FSKA-------CFEIR-NWQ SNSE-EV-LSRV--GE-GNPE----NVKRFSV-----------------------D-KTM DS--E-----------------RV--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------PY VRPFTFVGLDYFGPMI-------------------------------------------- ----------------------------VK--RG-R-----T-NI-----KR-WVA---L -FTCLT--VRALHLEVVHTLSAESC-----KMAIRRF-LARR-GAPQKIYSDNGTNFRGA AKELS-D-E------INA-IHR-E----------------------IS---GTFTNADTE ----WHFNPPAAPHMGGVWERKVRSVKEGLKV-LS--H---K-RHL----DDEGF----- --ITL-----LAEIEMIVNSHP--------LTF------------V-------------- ----------------------PL-------------ES--------------------- ----------- >385/1-562 ----THRIVLSEIARLFDPYGLVGPVIVLGKLFLQD-LWRG-K----------Y------ -SWDE-P-LSG--ELQLKWLEFRTNLRELD---A-ISVP--RWI--N------------- --FRKD-VV--SC-EFHG-FSDASDK-AYG-AAIYLR--CVNQ-DG------QVTI-N-- LLMA---------------------------KSRI-APL--E-DLSK------------- ---RKKK-------------------------QNIPRLELSAAL-LLA-HLFESVSSS-- -M-M----I---A---AKS---FF---------WT------------------------- -----------------------------------PEYYVPHHAV-------IKPD-STT TKL-RVVFDASCSTD-TG---VSLNDVLMVGPVVQ--DDLRSILLRFR---LFKY--AVV GDAEKMYRMVWQHKS--DQQLHK-----I------FWRDS---I-DE---------PL-R AYKLTTVTYGTASAPYLATRC-LNKC------------A----EDG-AERY--P-LGSVV V-KKS--FYVDDM-LAGAD-T---VEESQQLCKEVL-EL-LKGS-------GFNLR-KWN SNNP-EV-LKEIPLHLRDDRV--K-L-DLD---------------------------E-- -KATV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------SP APAFQRVGIDYCGPFE-------------------------------------------- ----------------------------LQNA--RRKG---APL------KC-YIC---L -FVCMV--SKAVHIEVVMDLTADAF-----LAALRRF-VARR-GRPEQIFCDNATNFVGA RRQLS-E-------LNRMFRQQ-QF------------------QERLS---TEAARNSIT ----FNFIPAKSPNFGGLWEAAVKSLKGHMRKVIG--T-----RRL----SQDEM----- --QTV-----VIQIEACLNSRP--------LTP------------L-------------- ----------------------SN--------DPA--D-------L-------------- ----------- >386/1-577 ----TKRMILSQIARIFDPLGFVGPVVTAAKLIMRE-LWSL-N----------L------ -DWDQ-P-VPS--EMANFWMDFRRQLRWLN---E-LKIP--RWI--L------------- --ADGARSV-----ELHG-FADASDL-AYG-ACLYTR--IVKD-DG------SATL-K-- LICS---------------------------KSRI-LPR--K--KGK------------- ---QKE--------------------------ITTPRAELLAAL-LLS-RLAVKQLEA-- -LD-------VKF---ESV---IL---------WS------------------------- -----------------------------------SAYYLPHHYV-------LKPS-SRT TKL-RVVFDGSAEST-TG---VSINNTQMIGPTVQ--NDLISIVSNFR---AYKY--GIT ADIPKMYRQVEVHAD--DRRYQR-----I------VHRSN---C-DQ---------PL-Q TYDLRTVTYGLASSPFLATMA-LKQL------------A----IDE-GTQY--P-LAAVA V-EKS--FYIDDV-LTGAN-T---LEDALELKTQII-GL-LRKG-------CFDVH-KIC SNSE-AV-LQDVPQDMRESVV------NIE---------------------------DPS INTVI-----------------KT--LG-------------------------------- -----VAWRPQEDCF----------------------------TFVVLVD---------- ----------------------------------------------------------QP SPVFANTGLDFAGPFK-------------------------------------------- ----------------------------IRPNAKMKNA---PTL------KG-YVC---V -FVCMA--TRALHLEAVSDLTTEGF-----MGALQRF-VSRR-GVVLKLYSDNATNFEGA NNEME-R-------LATLFREE-QH------------------QLKLN---EFCTQRAID ----WSFIPPRSPHFGGIWEAGVKSVKSHLKMIMA--E-----HKL----SFEQF----- --STV-----LVQIEAILNSRP--------LTQ------------L-------------- ----------------------SD--------DPN--D-------V-------------- ----------- >387/1-532 ----TRRGILSVVNSIYDPMGFGAAVIQPMKVLLQT-LCKS-K----------L------ -GWDE-R-IPP--KEQQKWLKWVNQLPKLS---N-FQVP--RCY--K------------- -PYTFGK--VTDI-QLHH-FSDASEE-SYG-SVSYIR--LVNS-LG------DVHC-S-- ILYG---------------------------KTRL-VPL--K-R---------------- --------------------------------LSVPRLELSAAT-ISI-RSDKMLRKE-- -L------Q-MPI---NSS---LF---------WT------------------------- ---------------T---------------GPLGKTWYIPHHGV-------YHPE-K-P DKI-RVVFDCSAK-F-KG---ICLNDNLLQGPDLT--NNLVGVLSRFR---RENV--ALM SDIQAMFHQVKVTES--DRDYFR-----F------MWWKH---GDIQ---------EELE EFRMSVFLFGTICSPSCANFA-LRKT------------A----DDN-RGSF--SSTVIDT V-HNC--FYVDDC-LTSTA-T---IQEAKVLVNDLS-EL-IAKG-------GFRIT-KWI SNSR-EV-LASI-------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PN KPPFSYVGVDYFGPFL-------------------------------------------- ----------------------------IR--KG-R-----S-NL-----KR-YGV---I -FTCLT--TRAIHIEVAHSLDTSSF-----IQALRRF-IARR-GQVQEIRSDNGTNFVGA ERELQ-H-------EIQKWNQS-S----------------------IH---NYLLQQQIK ----WIFNPPGASHHGGVWERQIRTIRKVLASVCK--E---Q--TV----NEESF----- --STL-----LCEVEGIINNRP--------LTT------------V-------------- ----------------------SN-------------D--------PLDL---------- ----------- >388/1-528 ---PTKRSVLSAIGQLFDPCGYLGPVTTTAKLLMQD-LWRL-K----------L------ -SWDD-E-LPE--EQYDLWTTFQEQLPLMN---E-LRKK--RCV--I------------- --TR-G-AA--AV-ELHG-FSDASKR-AYG-AVLYTK--CISP-DG------SVDV-E-- LVCS---------------------------KSRV-APL-------K------------- ---P----------------------------MTIPRLELCGTL-LLA-RLVEKTAAA-- -M-K----I-P-F---SNV---TL---------YT------------------------- ------------------------------DC-----YFLPHHAV-------YKES-SST TKI-RVVFDASAKTT-SG---ISLNDALAVGPTVQ--NDLVTILLRFC---SYPV--VLT ADIPKMYRQVRIHED--DRKYQR-----I------LWLDT---N-NE----------I-A TFELTTVTYGCASAPYLATRT-LIQL------------A----KDE-ASEL--P-LGSKV I-EEN--SYIDDF-LTGGN-S---EQEVIAIYQQLT-EL-LRRG-------GFGIH-KFC TNSE-VV-RK-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------I---------- ----------------------------------------------------------TP SPVFSNTGVDYAGPVY-------------------------------------------- ----------------------------LK--ETGRKK---TTY------KA-YIA---V -FICLA--TKAIHIELVSNLTTENF-----IAALQRF-ISRR-GMVTNMYSDNGTTFVGA NHELA-E-------LRKLFEDQ-TH------------------QRQLN---DFCISKGIE ----WHFIPPRSPHFGGIWEAGVKSIKHHLKRVVG--E-----TKL----TFEEM----- --TTF-----LAQCEAILNSRP--------LIP------------V-------------- ----------------------SD--------DPN--D-------I-------------- ----------- >389/1-556 ----TKRTILSVASSLFDPLGLVAPIIVTAKIILQE-LWIV-K----------L------ -QWDE-S-VPQ--NLYLAWKSFAASLTSLE---S-LKIP--RFC--M------------- --QPNT-K---EL-QLHG-FCDASIR-AYG-CCIYAR--TVAA-DG------EVQV-H-- LITS---------------------------KCRV-APT--R-K---------------- --------------------------------LSLPKLELAASH-LLA-QLYVKIKGI-- -F-T----S---K---Q--T--YL---------WS------------------------- -------------------------------------NYIPHHCV-------FKPN-STS TKL-RVVFDASNRTS-SQ---QSLNDLLMVGPTIQ--TDLYTLLLRFR---TYKY--ALT ADVVKMFRQVLVDYR--DRKFQS-----I------LWRDS---T-DK---------PL-R TYSLNTVTYGTASAPYLAIRS-MKYL------------A----DLH-MQTH--K-LGSQA I-NSS--FYVDDF-LCGHD-T---AEGLQQLKAEVI-EV-LGKG-------KFELA-KWH SNHP-DF--VDDSTIKDLNLE--------------------------------------- DGSVT-----------------ST--LG-------------------------------- -----LAWNQRLDVLLFAF----------------------------------------- ----------------------------------------------------------TP SRPFAHCGVDFCGPVN-------------------------------------------- ----------------------------VYLR--IQGK---APR------KA-YIA---I -FVCFA--TKAVHIEVVSDLSTDAF-----LAALRRM-IARR-GLPVDIFCDNATNFTGA SNQLK-E-------LRTYFFKQ-EN------------------QQSII---SFCTNEFIN ----FRFIPPRAPHFGGLWEAAVKSAKGLMTRSLM--N-----ARC----TFEEL----- --ATI-----TAEVEAILNSRP--------LTP------------L-------------- ----------------------SS--------DPS--D-------L-------------- ----------- >39/1-538 ---QTKRSVLSFVARLYDPLGLLSPIVTRAKVLLQE-MWLH-K----------L------ -GWDD-Q-LPV--QMRQEFEAVTSCFSNLN---S-LHIP--RYV--G------------- --TL-K-SK--GC-QIHG-FADASTR-AYG-CCLYVR--MQTD-KG------ITT--R-- LLVA---------------------------KSKV-APL-------K------------- ---T----------------------------KSVPRLELCAAE-LLA-TLWDAVRKV-- -L-D----C-P-I---NQV---TF---------WS------------------------- ---------------------------------------NPYQCV-------LRPH-NAS TKL-RVVFDASSKSS-SQ---LSLNDLLMVGPTIQ--PQLWETLLRFR---LRPW--AAT ADIAKMYRQIELDES--HRNFQL-----I------VWRET---P-TD---------PL-Q IFRLNTVTYGTATAPFLAIRC-LKHL------------S----DLH-ASTH--P-AAARS L-ARD--FYVDDL-LTGAD-S---VEELCLLHRDLI-AI-LQKF-------GFPLT-KWS SNCK-QL--AAQPARNDIVIG--------------------------------------- HQEDT-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------HG NRPFEISGVDFCGPIL-------------------------------------------- ----------------------------VSLG--IRGK---SPV------KM-YIA---I -FVCFT--SKAVHLELVTDLTTNSF-----LMCLSRF-VGRR-GLVRKLYCDNATNFVGA ARTL--D-------LKATFHGN-T--------------------ADME---MFAAERGME ----FVFIPPRAPHFGGLWEAAVKSAKGLLLKAMG--S-----ARL----RQDEV----- --ATV-----LVEVEAVLNSRP--------MVA------------P-------------- ----------------------SS--------N--------------------------- ----------- >390/1-559 ----TKRSSLSTIAKLFDPLGLVGPVVVVAKVFMQA-LWSL-K----------D-ENNKP YDWDT-E-LPD--HMKRRWIEYCSELPRLN---E-LRIN--RFI--L------------- --LQ-D-ST--AA-ELHF-FSDASLV-AYG-TCAYIR--SSNA-LG------TVKV-A-- LLTS---------------------------RSKV-APL-------K------------- ---Q----------------------------QSIPRLELCGAL-LAA-ELYLKVSTA-- -L-R----I-F-----SKA---YF---------WV------------------------- ---------------------------------SEPAYFIPHHPV-------IREK-STT TKV-RVVFDASCKSA-SG---VSLNDAMLVGPIVQ--EDLRAITMRSR---LHPI--MLI ADIAKMYRQILLSPE--DCQFHR-----I------FWRRS---L-AD---------PI-Q IYKLKTVTYGTASAPYLATRV-LKQI------------A----LDE-GTNF--P-IAARA A-SED--FYVDDF-FSGAS-T---VDEAIELREQMD-AM-LNSA-------GMQLR-KWA SNCP-DV-LEGVSPANRALEP--S-V-DFA---------------------------K-- -DQSI-----------------KT--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA SRPFSIVGIDFWGPIY-------------------------------------------- ----------------------------LKPR--HRRD---APP------KA-YVS---V -FVCFS--TKAVHLELVVDLSTAKF-----LQAFRRF-VSRR-GLCAEVYTDNGKNFVGA ANELR-K-------L---LSAE-EF------------------RHAVA---DECSSSXIR ----WHFNPXRXSHFGGLXEXAIKSAQKHFVXVXG--D-----XKL----AFDDM----- --ETL-----LVQIXGCLNSRP--------LTK------------L-------------- ----------------------SD--------DPS--D-------L-------------- ----------- >392/1-549 ---PTKRQALRVVMSPFDPAGLLSFFLIHGKILIQD-LWRA-K----------T------ -DWDQ-P-IPE--KLLGKWKRWINLFRYMD---Q-ISIP--RCY--F------------- -PQRSIQ-DIGSL-QLHI-YVDASEE-AYA-CVGYLR--ALFP-DG-------IHV-A-- LVGG---------------------------KSKV-APL--K-A---------------- --------------------------------HSIPRLELMAAV-IGV-RLAKTILNG-- -H------S-LKV---DKV---FY---------WS------------------------- -------------------------------------WYLPLGVV-------INPK-K-P SKI-RIFCDAAAK-V-DG---ISLNTMLMKGPDLL--NTLLDVLFAFR---EKRV--ALC ADLKEMFHQIKIRPE--DRHAQR-----L------LWRED---P-AE---------A-PD VYLMDVATFGATCSPCSAQFV-KNMN------------A----EEH-AKEY--P-AAAEA I-IRK--HYVDDY-LDSAD-D---EEEAVKLAQDVK-HV-HSLG-------GFNLR-NWL SNSK-DV-LARV--GE-GDPVPNLITEKCLQL-----------------------D-KHS ST--E-----------------RV--LG-------------------------------- -----MFW---------------------------------------------------- ----------------------------------------------------------AY VRPFSFVGVDYFGPIS-------------------------------------------- ----------------------------IR--VN-R-----T-IA-----KR-WVG---L -FTCMT--TRAVHLEVVHTLSAESC-----KMAIRRF-IGRR-GAPVEIRSDRGTNFVGS SNELK-Q-E------MGK-INH-Q----------------------LA---ETFTNANTK ----WVFNPPGAPHMGGAWERLVRSVKTALAA-MD--T---S-RTP----NEETL----- --ATI-----LIEAESVVNSRP--------LTY------------I-------------- ----------------------PL-------------ET--------------------- ----------- >394/1-562 ---FTKRQVLSVIATLFDPLGFIGATITAAKLFMQL-LWTC-E----------D-ENGKR LDWDQ-S-LPS--TVGESWRNFHMQLPALN---D-IRVD--RCV--I------------- --LP-Q-AI--QV-EIHC-FSDASQK-AYG-GCLYIR--SQDK-YG------NVKV-Q-- LLYS---------------------------KSKV-APL-------K------------- ---T----------------------------QSIPRLELCGAL-IAA-QIYEKVRSA-- -T-N----L-P-----VRT---TF---------WV------------------------- -----------------------------------KRCYLPHHPV-------VKEA-STT TKV-RVVFDASCKTS-SG---VSLNDGLLAGPVIQ--RDLRSIILRCC---TKQI--LLV SDVEKMFRQIFVRSA--DRPLQS-----I------LWRTS---P-TE---------EI-G VYELNTITYGTKPAPFLATRT-LNQL------------A----MDE-GERY--P-LAVQA I-TEE--TYMDDV-ITGCD-S---VEEAKELQIQLN-GI-MSSG-------GFQLR-KWA SNCA-EA-LHGIPECNLALRPSEG-I-RMD---------------------------P-- -DSSV-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------TI SRPFSKTGVDFFGPVF-------------------------------------------- ----------------------------IRPG--PRRT---T-V------KA-YGA---I -FVCMC--TKAVHIEVVSDLSTDRF-----MQALRRF-IARR-GRCTDLYSDNGTNFVGA RNQLQ-E-------LFSLLKDG-DH------------------RQQVA---DFCSAEGIN ----WHFNPPSAPHFGGLWEAAVRSAKHHILRVIG--I-----NPV----SLEDM----- --QTL-----LVQIEGCLNSRP--------LTQ------------M-------------- ----------------------SD--------DPE--D-------L-------------- ----------- >396/1-607 ----TRRNMLSTVCSIYDPLSFLGPLVLEGKRILQE-MCSL-K----------T------ -DWDD-P-APS--NLHMRWDKWRTDLVKIE---H-LDMK--RCY--K------------- -PDNFGA--ISKV-EVHH-FSDASLV-GYG-QCSYLR--LLNE-QS------RVHC-S-- LLIG---------------------------KSRV-VPL--K-P---------------- --------------------------------VTIPRLELTGRS-CFC-QDXCISXRX-- -L------G-LRH---VFK---LF---------LG------------------------- -------------------------------------NYVPHTGV-------YHPK-K-P NKI-RVVFDCSAE-Y-EG---YSLNNNLLQGPDLT--NGMVGVLLRFR---KEHV--AIM TDIKAMFHQFFVKKC--DRDFLR-----F------LWWEN---QDYN---------GNLV EYRMKVHLFGAASSPGVANFG-LKRA------------A----DDG-EERY--GSDAANF V-RNN--FYVDDG-LISVP-T---CKEAISLLQSSQ-AL-CANA-------GLLLH-KIT SNRR-EV-ISSF-------SKMDLADKLENIN-----------------------LHRDP -LPTE-----------------RV--LG-------------------------------- -----MIWCVENDSFRFKIELRDRPLTRRNMLSTVCSIYDPLSFLGPLV----------- ----------------------------------------------------------KE VPPFTYSGVDYFGPFY-------------------------------------------- ----------------------------IK--EK-R-----S-LV-----KR-YGV---V -FTCMA--SRAIHLESANSMDTSSF-----INSLRRF-LGRR-GPIRQLRSDRGTNMMGA ARELA-K-------NVQEMDHT-Q----------------------IT---SFLLKSNCD -WIDFKFNPPHASHMGGVWERQIRTIRDAMKPILL--Q---S-SPM----DDESF----- --RTL-----LVEIENIVNSRP--------LTC------------N-------------- ----------------------LL--------S----DAGAPEPLTPSHL---------- ----------- >397/1-545 ---PTKREILKVVMSLFDPLGLVSHFLVHGKVIIQG-TWAA-G----------T------ -GWDE-P-INE--DLNQKWRRWVSFFPKLD---E-LKIP--RCY--F------------- --SPFPS-NIDDL-QVHT-FVDASDI-AYT-CVVYFR--LVY--DG------HIQT-A-- LVGT---------------------------KSKV-APL--K-T---------------- --------------------------------LSTPRLELKAAV-LGV-RFVAAILEY-- -H------S-LPV---SKR---FF---------WS------------------------- -------------------------------------WFLPLGVV-------VHPK-K-P NKI-RLVWDAAAM-V-DG---VSFNSKLLKGPDLL--TPLPAVLSRFR---QYPI--AVC GDIKEMFHQLLIREQ--DRMAQC-----F------LWRNN---P-GD---------P-IA VYVMDVATFGATCSPASAQYV-KNLN------------A----QEF-AELY--P-RGATA I-IKG--HYVDDY-LDSFM-T---VEEATDVVREVT-LI-HSQG-------GFEIR-GFR SNST-EL-LREI--GEK----IAAE-PKELML-----------------------E-RNS SS--Q-----------------SV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PF VRPFTYVGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-HA-----KR-WIA---L -FTCLS--IRAVHMEIVHSLSTESC-----IMAVRRF-VSRR-GSPAVFYSDNGTCFQGA NKQLQ-E-E------IGA-SNE-E----------------------FA---VTFTNAETK ----WKFIPPASPHMGGVWERLVRSIKTAVGSALE--H---P-RKP----NDETL----- --ETI-----INEAEALVNSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >398/1-549 ---PTKREVLRTLMSIFDPLGLLSHVLVGLKILFQE-IWRS-A----------I------ -GWDD-E-IPD--NLYEKWENWLRILPKLE---D-VSIP--RCY--R------------- -LLTSMS-PNTLV-QLHT-FVDASEL-GYA-AVVYLR--FQQ--GS------TIEC-A-- IVGA---------------------------KSRV-APL--K-F---------------- --------------------------------VSIPRLELQSAV-LGS-RLAKTISEA-- -L------S-FKI---NER---FF---------WT------------------------- -----------------------------------RIWYIPIFPV-------FNVN-K-P GKL-RLVWDCAAK-T-GN---ISLNSMLIKGPDQL--TPLNSVLYRFR---ENKV--GIT GDIREMFLQVRIAKE--DQGCQL-----F------LWKDN---P-ND---------ETPS TYVSQVMTFGASCSPTCAQFV-KNLN------------A----EKY-AGQF--P-RAVEA I-TKQ--HYVDDM-LVSVE-S---EEEAVQLAKDVR-SI-HAEA-------GFEIR-NWI SNSP-AV-LQAL--HQ---EKTA---DKSLYV-----------------------GSE-L ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY TRPFSYVGVDYFGPMT-------------------------------------------- ----------------------------VA--VG-R-----R-NE-----KR-WGV---L -ITCLT--IRAVHLEVAHSLSADSC-----IMALRTF-MARR-GVPIQIYSDRGTNFVAA NKELS-E-------ALREMDQQ-Q----------------------VI---QEITSQHTE ----WTFIPPASPHMGGAWERLIQTVKANLQKMLP------M-RRP----SDEVL----- --RNT-----LAEIENLINSRP--------LTY------------V-------------- ----------------------PV-------------DDPDAPVLTPNHF---------- ----------- >399/1-546 ---PTKRQVLKCLMSFYDPLGLLALFTVQGKIILQA-IWRS-N----------T------ -QWDQ-Q-IGA--VIRNRWQQWIQILVDLQ---H-LHFP--RCY--F------------- -DQATLK-YYQHV-QLHI-FVDASEE-AYA-AVAFFR--IVDP-QG------RVCC-S-- LVAA---------------------------KTKV-API--K-P---------------- --------------------------------ISIPRLELQAAV-LGV-RLMQWIVEG-- -H------S-IRI---EKK---VF---------WT------------------------- -------------------------------------WYLPLGVV-------FNPK-K-P NKV-RLIWDAAAK-S-HG---VSLNDMLLKGPDQL--TSLPAVLFRFR---QFAI--AVS ADIAEMFHQIGIVEG--DRHAQR-----F------LWRED---P-FT---------A-PE VFLMNVATFGSTCSPASAQFV-KNKN------------A----LEF-RQQY--P-RAVQS I-VKN--HYVDDL-LESFE-T---EEEAAKVIQEVR-MI-HAHG-------GFNIR-NFQ SNSP-VV-LDSV--GEK----SALN-PCSLDL-----------------------H-QAE RS--E-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------SF IRPFSYVGLDLFGPLL-------------------------------------------- ----------------------------VK--LG-R-----S-NA-----KR-WIA---L -FTCLT--IRAVHVEVVYSLSTDSC-----VMSVRRF-VSRR-GAPVEIHSDNGTNFRGA DRLLR-E-Q------IQN-INE-A----------------------MA---ETFTNTTTK ----WVFIPPSAPHMGGSWERMVRSVKVAMEAA-N--G---G-RRL----DDEGL----- --ITL-----AVEAEGIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >40/1-557 ----TKRVVCSELAQIFDPLGLFAPVVVKAKIFMQQ-LWEL-K----------L------ -DWDD-E-LPL--QHQTEWKEYRDDLQTLN---K-MQIP--RHI--Y------------- --DGKI-PV--TQ-ELHT-FVDASER-AYG-AAVYVR--ATYK-NN------QVSV-R-- LLCS---------------------------KSRV-APT--A-K---------------- --------------------------------QSLPRLELCAAV-LGA-ELTNRVRQD-- -L-H----M---D---INTVSG-----------WF------------------------- -----------------------------------RHYFIPHHCV-------LKPE-STT TKL-RVVFDASCKST-SG---KSLNDILQAGPTVQ--SELMSILLRFR---IHKY--VFT ADIEKMYRQVWMNPE--DQFHQM-----I------VWRNN---P-SE---------EI-R YYRLKTVTYGTTAAPFLATKC-LDHL------------A----IQY-KDRL--P-VGSTT L-KTD--FYVDDC-LTGAN-T---IPEAIHVRQELN-KI-LLPS-------GFKLR-KWC SNNE-QL-LQGIPKEDIVTDVKLG-ET-LE------------------------------ -HYSV-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------TQ ARPFLNAGVDYCGPIS-------------------------------------------- ----------------------------IHHK--IRGK---RPD------KA-YIA---V -FCCFS--TKAVHLELVSDLTTDAF-----LAALRRF-LSRR-GKCQTIHCDNATNFVGA NNQLK-E-------LEDSIFSS-KA------------------SALIT---NHCNKKQVD ----FKFIPPRAPSFGGLWEAAVKSAKKLLITTTN--T-----ASL----TFEEL----- --NTV-----IIEIEAILNSRP--------ITP------------M-------------- ----------------------SN--------DPT--D-------T-------------- ----------- >400/1-546 ---PTKREVLRVLMTIFDPLGLISNFLSYLKILLQQ-IWRS-G----------V------ -QWDE-E-IDS--EAYDKWLIWLKVLPRVE---Q-VRIP--RCY--N------------- -SQDLMN-ETDEV-QLHT-MVDASEN-GIA-AVCYLR--FVK--HE------SIRC-S-- IVSA---------------------------KTRV-APL--K-F---------------- --------------------------------ISIPRLELEAAV-IGA-RLARSVEAS-- -L------T-IEI---HRK---LF---------WS------------------------- -----------------------------------RRWYLPVFPV-------TNPN-K-P GKV-RLVWDAAAS-A-YG---TSLNSALLKGPDLL--CSLFTILLRFR---ERRI--GLT GDIREMFHQVLIRAE--DQLSQC-----F------NWMND---R-GE---------A--E VYAMQVMTFGACCSPSTAQFV-KNTN------------A----ERF-VNEY--P-SAHHA I-TKC--HYVDDM-LVSVD-T---EEQAIELAKNVK-YV-HEQG-------GFEIR-NWI SNSR-KV-KTAL--QG---EDTN---EKSLDL-----------------------FSE-L AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TRPFTHVGIDCFGPIE-------------------------------------------- ----------------------------VV--VG-R-----R-VE-----KR-WGM---L -VTCLT--VRAIHVEVLHSLSSSSC-----IMALRNF-MARR-GTPQTVHSDRGTNFVGA NRELL-Q-------TSEAINED-E----------------------FM---KEFANRGIE ----WVFNPPLSPHMGGSWERLIRTIKNNLKVVCS------S-RRL----SDEVL----- --RNL-----LAEVENIINSRP--------LSH------------V-------------- ----------------------PI-------------DE--------------------- ----------- >401/1-552 ---PTKRQVLRVVMSIFDPLGLVATFVVHGKCLIQD-IWRA-G----------V------ -GWDD-P-IPE--QLASQWRRWVEVLRHLN---Q-VKIP--RCY--F------------- -PGYEPR-SLDSL-ELHV-FVDASEA-AYA-CAAYFR--IVD--RG------QVRC-A-- LVSA---------------------------KTKV-APL--K-P---------------- --------------------------------MSVPRLELQAAV-IGV-RLMKSVQEN-- -H------T-LPI---SRR---MI---------WG------------------------- ---------------S---------------SDPRSVWYLPLGVV-------QNPN-K-P GKV-RVVWDAAAK-T-SG---VSLNSMLMKGPDLL--TSLPSVLFRFR---QREV--AIT GDIKEMFHQIMIRPE--DRQAQR-----F------LWRDN---P-ED---------Q-MQ EFVMDVATFGSTCSPCSAQYV-KNKN------------A----EEW-KQIY--P-EASEA I-VDN--TYVDDY-ANSSD-T---VEEVVRVALEVK-EI-HASA-------GFEIR-NWL SSSE-QV-LRRV--GE-QSSE----SAKHFIA-----------------------E-KST DT--E-----------------RV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PY VRPFTFIGIDYCGPFL-------------------------------------------- ----------------------------IR--IG-R-----S-NM-----KR-WVV---L -ITCLT--IRAVHLEVASTLSSESC-----KMALRRF-IARR-GAPQEIYSDHGTNFVGA SRELR-E-E------VSA-VNR-D----------------------LA---KTFTNRDTQ ----WRFNPPAAPHMGGAWERLVRTVKSSLET-LS--V---T-RTP----DEETF----- --QTL-----LVEVEGIVNSRP--------LTF------------V-------------- ----------------------PL-------------DT--------------------- ----------- >402/1-579 ---PTKRKFLSLIMSTFDPMGFLSCFSITGKLLLRE-IWRR-N----------V------ -LWDE-P-LPK--ELNSAFQKWRHQLEGVG---L-FRCP--RHY--F------------- -GSETVK----SI-QLHV-FTDASES-AYA-AVAYWR--ATYQ-NG------DVRV-S-- FVSG---------------------------KTKC-APM--R-T---------------- --------------------------------MSVPRLELQAAV-LGT-RLMNAVKSG-- -H------C-MEA---EDA---IL---------WT------------------------- ---------------A---------------VGSGKIWYLPHFAV-------TNPN-K-P GKI-RLVFDAAAK-V-GN---VSLNSELLKGPQHY--RPLLSVLFHFR---EGAV--AVT GDIKEMFHQIYVQPQ--DRRSQR-----F------LWRDG---D-RQ---------READ VYEMQVMTFGAACSPSAAHHV-MTLN------------A----MRH-QQVD--P-RAVKA I-TDY--HYVDDY-VDSFA-T---EDEAISVSARVR-DI-HKTG-------GFELR-RFQ SNSP-KV-VESL--GQEGTTNPVGWAEAE------------------------------- ----E-----------------KI--LG-------------------------------- -----LYWQPATDEFRFNVKYQRIK------DDVPTXRXFLSLIM--------------- ----------------------------------------------------------PG XWPFEYTGLDYFGPLL-------------------------------------------- ----------------------------VT--VG-R-----R-QE-----KR-WVA---L -FTCLR--TRAIHLELAHDLSTDSC-----ILAMRNF-MCRR-GPVTKLRSDNGKNFIGA DREAK-R--------FTDVFEADK----------------------IQ---DELATRCVE ----WIFNCPLNPAEGGVWERMVQCVKRVLAHTVK--E-----VAP----KEHVL----- --QSL-----LIEAENIVNSRP--------LTH------------M-------------- ----------------------PI-------------SV--------------------- ----------- >403/1-575 ----TKRLVLSESARLFDPLGLLGPIVLRSKLFMQE-LWKS-K----------V------ -SWDL-P-LSE--SQQQFWIDFRSDLNVLD---E-FSVP--RWA--A------------- --SAKD-PV--KA-ELHG-FSDASES-AYG-ACIYLR--MVSN-GG------SVSV-H-- LITA---------------------------KSRV-APK--G-TEKL------------- ---DQL--------------------------IRLPRLELCGAL-LLS-HLFEKVESS-- -L-Q----I---Q---ASP---FF---------WT------------------------- ----------------------PINPSNTVLLPSEKIYYMPHHCI-------VRPD-SAT TKL-RVVFDASCATD-SG---VSLNDALMVGPVVQ--DDLFSILLRFR---IPRF--VIV ADLQKMYRQVLVYPS--DRSLQR-----I------VFRSS---P-VE---------PI-Q TYELRTVTYGTASAPYLATRC-LQQL------------A----SDG-ESTH--P-KAAKV L-SKS--FYIDDL-LSGVE-S---EEEGIELCRQLI-DL-LRSA-------GFKLH-KWA SNSP-NI-LRNIPAELREDRS--L-L-ELD---------------------------S-- SSSPV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------SP TLPFLNSGVDFCGPFY-------------------------------------------- ----------------------------LRPH--SRKA---APL------KV-FVA---V -FVCLS--TKAIHLELVGNLSSESF-----IASLKRF-AARR-GVPKTIYCDNGTNFVGA QRALN-E-------FLQLFRSQ-QS------------------RLDIT---RQCSEEGIQ ----FSFIPPRSPHFGGIWEAAVKSLKTHLRRTLA--N-----ALV----TAEQF----- --HTL-----LTQIEALLNSRP--------LTQ------------L-------------- ----------------------SN--------SPE--D-------L-------------- ----------- >404/1-559 ----TKRKIMSYIAQIFDPLGLVGPTVTKAKLFMQR-LWAL-K----------T-PNSER YEWDQ-P-LPP--KLQQEWKEFHTTIDLLR---E-VRIP--RFA--S------------- --VV-D-AV--SI-QLHF-FADASDK-AYG-TCCYVR--AQS--AQ------EVSV-K-- LLVS---------------------------KSKL-SPL-------S------------- ---AR---------------------------HTIARLELCAAH-LST-QLYKKVASS-- -L-R----N-V-----PPA---YF---------WS------------------------- -------------------------------------CYLPHHPV-------FKLS-STT TKT-RVVFDASCKTT-SG---HSLNDILLVGPVVQ--DDLLSLVIRFC---FHRI--ALS GDIEKMYRQVRLHDD--DQPYQR-----I------KWRSD---A-SE---------PI-A TYQLQTVTYGTASAPYLATKT-LQRL------------A----SDA-GNNF--P-SAAEP V-SKD--FYVDDF-LSGAD-D---VDSAIRIRRDVS-AI-LDSA-------GLPMK-KWA SNSV-EV-LEDIPPEDRSVQP--W-Q-DLQ---------------------------D-- -PQSV-----------------ST--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------SP TRPFSVCGVDYCGPLF-------------------------------------------- ----------------------------VKSP--VRKR---GPT------KV-YVA---I -FICFS--TRAVHIELVSDLTSAAF-----LAALRRL-VARR-GKISELHSDNATTFKGA SHALH-R-------VYQMLKLD-DTD-----------------RNRIL---SWCADNEIR ----WKFIPPRAPHFGGLWEAAVKSAKTHLLKEIG--N-----TSL----SYEDM----- --LTL-----LAQVEMCLNSRP--------LTP------------M-------------- ----------------------SS--------EPS--D-------L-------------- ----------- >405/1-550 ---PTKREVLKVVMSLFDPLGLISFYLVHGKVLIQD-IWAA-G----------C------ -SWDG-A-IGD--ELYAKWRQWINLFPMLQ---S-IKIP--RCY--F------------- -NKPLPE-DLKGI-ELHV-FVDASSS-AYA-CSAYFR--LPS--ET------GIQV-T-- LVTA---------------------------KTKV-API--K-T---------------- --------------------------------LSIPRLELKAAV-LGV-RLTESVQSH-- -H------K-FSI---SRR---IF---------WT------------------------- -------------------------------------WFLPLGVV-------RNPK-K-P QKI-RLIWDAAAK-S-HG---VSFNSKLLKGPDLL--TPLVAVLSRFR---QYPV--AVC GDIREMFHQISIIPQ--DRSSQC-----F------LWRDE---P-TD---------R-IQ TYVMDVATFGSTCSPTSAQFI-KNRN------------A----EEF-AKEF--P-RAAAA I-VDN--HYVDDY-LDSFR-T---VQEAIEVTNDVR-LI-HSRG-------GFELR-NFS SNSE-KL-LQGI--GET----PDRT-GKALVL-----------------------M-RGE -V--E-----------------SV--LG-------------------------------- -----MQWLPMED----------------------------------------------- ----------------------------------------------------------AY IKPFTSVGLDYFGPIP-------------------------------------------- ----------------------------VK--VG-R-----S-QV-----KR-WVA---L -FTCLS--IRAVHLEVVHSLTTESC-----IMAVRRF-VARR-GPPAEVYSDNGTCFHGA NRELQ-L-Q------MRE-TNE-A----------------------MA---LTFTSAQTR ----WIFNPPSAPHMGGVWERLVRSIKSATNVLLE--S---P-RNP----DDETL----- --LTI-----LYEAECMVNSRP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >407/1-515 ---PTKREMLRLVMSIYDPLGLVASFVIHGKILIQE-VWRT-E----------T------ -DWDS-H-IPE--EIAARWAEWIAVLNKMN---G-LRIP--RCY--F------------- -PGYDPE-SFKTL-QLHV-FVDASAQ-AFS-AVAYFR--IID--QG------QIRV-A-- LVSS---------------------------KTKV-APL--R-G---------------- --------------------------------LSIPRLELMAAL-LGA-RLRKTIEQN-- -H------S-LKI---RKT---YF---------WS------------------------- -------------------------------------WYLPIGVV-------VNEK-K-P GKV-RIIWDAAAK-V-DG---ISLNTMLLKGPDLL--TPLLSVMFPYR---ERQV--AVS ADIKEMFLQIMIRQQ--DRSALL-----F------PYRDS---P-DL---------P-MT TMVSDVAIFGAACSPAHSQYV-KNLN------------A----TEQ-EAEL--P-RGAAA V-KKR--HYVDDY-VDSFD-T---VEEAVEVAKEVI-EV-HKRA-------GFHIR-NWM SSDG-SV-L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PC VRPFTYVGVDIFGPYL-------------------------------------------- ----------------------------VK--VG-R-----I-AA-----KR-WVC---L -FTCLT--IRAVHLEVVTSLSTDAC-----KKAIRRF-VARR-GSPQEIYSDNGTNFVGA SRELQ-D-E------IGR-IYT-E----------------------LG---STFTNAQTQ ----WRFNPPAAPHMGGCWERMVRAVKSALGC-IP--V---V-RKL----DDESF----- --VTV-----LVEAENMVNSRP--------LTF------------I-------------- ----------------------PL-------------ET--------------------- ----------- >408/1-577 ----TKRTVLSVIATLFDPLGLLGAVITTAKVFMQQ-LWTI-R----------D-ENGQP LDWDK-P-LPP--TVGEAWWKFHEQLPLLN---H-PRIE--RCV--I------------- --IQ-K-AV--GV-EIHC-FSDASEK-AYG-ACLYIR--STDE-DG------RVKV-R-- LLSS---------------------------KSKV-APL-------K------------- ---C----------------------------QTIPRLELCGAV-LGA-QLFEKVRES-- -I-R----M-T-----TTC---YF---------WT------------------------- ------------------------------DDTSTKRCYLPHHPV-------VKES-STT TKV-RVVFDASCKTA-TG---VSLNDVLLVGPVVQ--EDLRSIILRSR---TKQI--MLV SDVEKMFRQINVRPE--DRQLQC-----I------LWRNS---Q-SE---------DV-R TYELNTVTYGTKPAPFLATRT-LHQL------------A----LDD-EDRF--P-LAARA A-IED--TYMDDV-ITGAD-D---VETATELQLQLN-AM-LSGG-------GFLLR-KWA SNCP-SA-LDGISQENLAIRSMDG-I-NLD---------------------------P-- -DPSV-----------------KT--LG-------------------------------- -----LTWFPTTDILGFQF----------------------------------------- ----------------------------------------------------------TI ARPFLNTGVDYFGPIY-------------------------------------------- ----------------------------LRPV--PRRG---V-V------KA-YVA---I -FICLC--TKAVHLELVSDLSTDRF-----LQALRRF-VARR-GRCAKMYSDNGTNFVGA RNKLQ-D-------LLKLLKSR-DH------------------HDSVS---KECARDGIQ ----WHFIPPSAPHFGGLWEAAVRSSKHHLLRVLG--E-----TPV----SPEDF----- --NTL-----LTQVEACLNSRP--------LTP------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >409/1-561 ---PTKRXVLSEISRLYDPLGFLGPVGVIAKLTMQE-LWRL-K----------L------ -DWDD-E-LPE--EQMEXWXTFREQILSIR---N-IRKK--RCV--I------------- --PA-G-AQ--RI-ELHG-YVDASKR-AYG-ACLYVR--CILA-DG------KINV-Q-- LLCS---------------------------KSRV-APL-------K------------- ---P----------------------------VTIPRLELCAGL-VLA-QLTRKSMEA-- -L-E----V-N-F---DSV---TL---------WS------------------------- ------------------------------GNDPAGGYFLPHHAV-------CKEN-SST TKT-RVVFDASAATT-TG---ISLNDTQLVGPTVQ--SDLITLILRFC---THQV--VLT ADVPKMYRQVQVHPE--DRRYQR-----I------VWLND---K-GE----------M-V TFELTTVTYGCSSAPYLATRS-LIQL------------A----KDE-ANEF--P-LASRV V-KKD--SYIDDF-ITGGR-T---AAEVVETYEQLQ-AM-LKRG-------GFGAH-KFC SNSS-EV-LRAIPAELQEQQV------DFE---------------------------SSE VNNTI-----------------KI--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------TP SPXFSKXGIDFAGPFV-------------------------------------------- ----------------------------LK--ESGRKP---RFF------KA-YVC---V -FVCMS--VKAVHLELCTDLRSETF-----LAALQRF-VSRR-GLPSDLFSDNGTTFVGA NHELA-S-------LRKLFEDQ-AH------------------TEKLA---EFCSAKGII ----WHFIPPRSPHFGGIWEAGVKSMKHLLKRVVG--E-----TRL----TYEEM----- --ATF-----LTEAEAVLNSRP--------LCP------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >41/1-583 ---PTKRSVLSDMSKLFDPHGLLAPVVLIAKLVMQQ-LWQQ-N----------V------ -GWDD-A-IPK--EQFRIWNRFRSELCCLN---S-LRID--RRI--T------------- --ID-D-TV--AV-ELHG-FADASKV-AYG-CCIYMR--SVKS-DG------AAEV-R-- LICG---------------------------KSRV-APM-------K------------- ---ELQRDIKVDATPDE---------------MTIPRLELCAAL-LLA-EQVDKVRET-- -L-A----L-T-T---AKV---VL---------WS------------------------- -----------------------------------SVYYLPHHCV-------IKPD-SST TKL-RVVFDASAKSS-SD---LSLNDVMEIGPTVQ--ESLFNVILRFR---LHKF--VFT ADIPKMYRQVMVHEA--HRKYQR-----I------LWRED---K-NQ---------PM-K ELELNTVTYGTAAAPFLATRS-VVQL------------A----RDE-QEDF--P-AASEA V-EKC--FYVDDV-MTGAD-T---LSDARQLQRDLI-AL-LDRG-------GFQLH-KWC ANDE-AL-LEDIPSHAREKQM------NFE---------------------------DCE INGVI-----------------KT--LG-------------------------------- -----ILWDPSSDEFLFHVKPI-------------------------------------- ----------------------------------------------------------TA AQPFARTGIDFAGPFF-------------------------------------------- ----------------------------IK--VGRMRA---K-V------KV-YVC---L -FVCMS--TKSIHLELVSSLTTDGF-----LAALHRF-ANRR-GNPSELFSDNGTNFRGA DRELS-E-------LLNLLQSQ-VL------------------DDKVN---EFCQPRGIK ----WSFNPPKAPHQGGIWEANIKCMKSHLCKTLN--E-----SYL----TYEEL----- --NTL-----LIQIEGVLNSRP--------LVQ------------L-------------- ----------------------TD--------DPF--D-------Y-------------- ----------- >410/1-543 ---PTKREVLRTLMLLFDPLGLIAHFTMLLKVLLHE-IWRT-S----------V------ -GWDD-A-IED--TQFAKWLVWLHALPYVQ---D-IRIP--RCY--R------------- -ISISLE-KGVEI-QLHT-FMDASEN-GFA-AAVYLR--FQK--DD------AIEC-S-- LVGA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQSCI-LGV-RLSDTILQS-- -L------S-VKI---NRQ---FY---------WT------------------------- -----------------------------------RVWYLPMFPV-------WNPN-K-P GKT-RLVWDAAAA-A-HG---VSLNSVLLKGPDQL--TSLLRILIKFR---EFKV--AVC ADIREMYHQVLMRED--DQHCLR-----F------FWKQE---E-SD---------SEPS IYVMMVQPFGACCSPSIAQHV-KNHN------------A----ERF-AQEC--P-VAVQA I-TDC--HYVDDM-LISVE-T---EEEAVQVSNDVR-EI-HKQG-------GFEMH-NWL SNSS-LV-IQTL--QQ---PIAK---EKDFST-----------------------SQD-T TT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TLPFVYMGVDYFGPLF-------------------------------------------- ----------------------------VV--VG-R-----R-TE-----KR-WGV---L -ATCLT--TRAICIEIAHTLNTDSC-----VMALRNV-MVRR-GVPAVIYSDRGTNFQGA SKEMQ-Q-------EMHDL-QE-R----------------------LA---SKFTTPKTE ----WVFIPPASPHMGGAWERMIRTVKQNLYKLQP------N-RFP----SDEVL----- --RNT-----MLEIENVVNSRP--------LTE------------I-------------- ------------------------------------------------------------ ----------- >411/1-548 ---PTKRQLLQVVMSIFDPLGLVSLIVVHGKILVQK-SWRA-N----------I------ -GWDD-K-IDE--DLLKLWRRWTELLGQLD---T-VRIP--RCY--F------------- -PGYLPE-SYESL-QLHI-FVDASEE-AYV-ATAFFR--IVD--QS------QVRC-A-- LVAS---------------------------KTKV-APL--K-L---------------- --------------------------------LSIPRLELQAAL-LGA-RLAKSVAEN-- -H------T-LRI---KQR---FF---------WG------------------------- -------------------------------------WYLPLGVV-------VHPK-K-P GKV-RIVWDAAAT-V-QG---QSLNSALLPGPDLL--SSLPSVLSKYR---QRQV--AIC GDIREMFHQFQIRPE--DRQAQR-----F------LFRSD---P-SK---------A-PD IYVMDVATFGVTCSPSAAQFI-KNKN------------A----KEF-ESEF--P-EAAAA I-VHN--HYVDDY-LDSRD-T---VDEAADMALQVR-TV-HAKA-------GFHIR-NWM SNSR-EV-LLRV--GD-SAEG----SAKNFKT-----------------------H-AAT VS--E-----------------RV--LG-------------------------------- -----MSWDFG------------------------------------------------- ----------------------------------------------------------PR IRPFSFVGVDYFGPLL-------------------------------------------- ----------------------------VV--QG-R-----R-EV-----KR-WIA---L -FTCLT--IRAIHLEVVTSLSTECC-----KMALRRF-IARR-GAPSEIYSDRGTNFVGV SGELS-K-Q------VRA-INQ-E----------------------LA---STFTNTVTQ ----WRFNPPAAPHMGGSWERMVRSVKCALAS-LS--V---E-RKP----SEEVL----- --VTL-----LVEAESMVNSRP--------LTY------------M-------------- ----------------------PL-------------QT--------------------- ----------- >412/1-550 ---PTKRQVLRCVMTLFDPLGLLATFLIHGKVLIQE-LWKT-G----------I------ -DWDE-K-VTD--DQFIRWRDWVQMIQFID---M-IRIP--RCY--F------------- -SSATQQ-TYENA-QLHV-FVDASPV-AYC-CVVYIR--VTDQ-EG------YGRC-S-- LAAA---------------------------KAKV-APL--K-P---------------- --------------------------------MSVPRLELQGCV-LGV-RMLKFVEEN-- -H------S-ISF---SKR---FL---------WT------------------------- ---------------N---------------ADPRRVWFLPLGAV-------TNPK-K-P NKV-RIIWDAAAK-V-DG---SSLNSHLIKGPDQL--TALPSVLSRFR---QFGI--AVS ADIQEMFHQILIKPE--DKHSQR-----F------LFRFD---T-EQ---------P-PS QYVMDVATFGATCSPASAQFV-KNLN------------A----QEH-SYQY--P-QAAQR I-VDN--HYVDDY-LDSFE-D---EDEAKQITEQVR-LV-HRNG-------GFNLR-NWN ANSD-AV-LQYL--DEP----AVNG-DKNINL-----------------------I-NKE HT--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------AY SRPFSYVGLDYFGPLL-------------------------------------------- ----------------------------VK--QG-R-----T-NV-----KR-WIA---L -FTCLT--VRAVHLEVVNSLTTSSC-----VSAVRRF-IGRR-GAPIEFYSDNGTNFQGA ERLLR-E-Q----------IEQ-E----------------------LS---STFTSARTK ----WFFIPPGAPHMGGAWERMVQSVKAAMGEA-Y--G---D-GKL----DEEGL----- --WTL-----VVEAESVVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >413/1-573 ---PTKRIVLSEISKLFDPLGFLGPVVTTAKLIMQE-LWRL-K----------L------ -DWND-E-LPD--EQMQLWLAFREQLVAVR---Q-IRKK--RCV--I------------- --PG-N-AV--KI-ELLG-YCDASKR-AYG-AVLYVR--SELN-DG------TINI-Q-- LVCS---------------------------KSRV-APL-------K------------- ---P----------------------------TTIPRLELCGAL-VLA-QLVQKAIES-- -L-K----V-K-F---DSV---TL---------YS------------------------- ------------------------------SDNPEHGYFIPHHAV-------YKDS-SST TKV-RVVFDASAASS-TG---VSLNDTQLIGPTVQ--SDLVTIMLRFC---THQV--VLT ADVPKMYRQVQIHPD--DRVYQR-----I------VWLND---A-NE----------M-T TFELKTVTYGCSSAPYLATKA-LTQL------------A----TDE-ADAF--P-LAARV V-KED--SYVDDF-ITGGK-S---AADVKETYSQLT-NM-LSRG-------GFGVH-KFC SNSA-EV-LQLIPPELQEKQV------DFE---------------------------MSE INDTI-----------------KT--LG-------------------------------- -----LIWNPSYDYFVFN-------------------------------V---------- ----------------------------------------------------------TP APVFASTGVDFAGPFI-------------------------------------------- ----------------------------LR--ESGKKP---KFV------KA-YAA---V -FVCMA--VKAVHLELCTDLRSETF-----LAALQRF-TSRR-GIPSDLFSDNATTFTGA ANELA-E-------LRELFQSQ-LH------------------KDKLA---EFCTTKGIT ----WHFIPPRSPHFGGIWEAGVKAMKHMLKRVVG--E-----TRL----TYEEM----- --TTF-----LSEAEAIMNSRP--------MCP------------L-------------- ----------------------SD--------DPN--D-------FP------------- ----------- >414/1-550 ---PTKNEVLRVLMTVFDPLGLISNYLMHLKIVLQE-VWRS-G----------V------ -QWGQ-L-IQD--KQFEAWKAWVKLLPLLE---Q-VSLP--RCY--R------------- -KVTSAG-SATEI-QAHI-FVDASEN-GMA-AAVYLR--FEE--AG------QIEC-M-- LMCA---------------------------KTRV-APL--K-Y---------------- --------------------------------LSIPRLELTAAV-IGT-RLINSMMPE-- -L------A-LPI---SKR---FF---------WS------------------------- -----------------------------------RVWYLPVFPV-------VNQN-K-P GKV-RIVWDAAAA-F-HG---VSLNSALLTGPDEL--TSLPAVLCQFR---KYRI--GIC GDIREMFHQVRIRPV--DQHCQR-----F------LWRGT---A-AD---------QEPD TYVMNVMTFGACCSPSTAQFV-KNQN------------A----ERF-KEQY--P-AATDA I-VKK--HYVDDM-LASEE-T---EEAAIELAKAVR-FV-HAEG-------GFEIR-NWI SNSP-RV-LAELRRND---ERTA---QKNLDL-----------------------TAE-L ET--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY TRPFSHVGVDYFGPIE-------------------------------------------- ----------------------------VT--LG-R-----R-VE-----KR-WGV---L -LTCLT--VRAVHLEIAHSLSTNSC-----IMALRNF-VVRR-GTPVSFYSDRGTNFIGA DRELR-E-------ALKTVDQE-M----------------------IM---KEFTSPQTA ----WHFNPPASPHMGGSWERLIQSVKRNLGEIVG------N-RRP----NDEEL----- --RNA-----LIEVEGVLNSRP--------LTD------------V-------------- ----------------------PV-------------DD--------------------- ----------- >415/1-562 ----THRVVLSEIARLFDPYGLVGPVIVQGKLFLQE-LWQA-K----------Y------ -SWDE-L-LSD--DLHTRWLEFRRNLSDLD---A-ISVP--RWI--A------------- --FGRD-VI--SC-EFHG-FSDASDK-AYG-ATIYLR--CVSR-DG------EIAV-N-- LVMA---------------------------KSKV-APL--E-DLSK------------- ---RKKK-------------------------QSTPRLELSAAL-LLA-HLYESVASS-- -L-E----I---A---AAA---FF---------WT------------------------- -----------------------------------QEYYIPHHAV-------LKPD-STT TKL-RVVFDASCPTD-SG---VSLNDVLMVGPVVQ--DDLRSILMRFR---LFRY--AVV GDAEKMYRMIWQHPS--DQLLHK-----I------YWRDS---A-QE---------QL-R TYQLTTVTYGTSSAPYLATRC-LNKC------------A----EDG-VDRY--P-AAAAV V-KKS--FYVDDM-LAGFH-T---IEEGKQVCKDVR-EL-LKGS-------GFNLR-KWN TNTP-EV-LSEIPSDLRDDRV--V-L-ELD---------------------------E-- -KATV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------SP APAFQRVGVDYCGPFE-------------------------------------------- ----------------------------LRPA--TRKG---API------KC-YVC---L -FVCLV--CKAVHIEIVMDLTSEAF-----LAALRRF-VARR-GRPDIILCDNATNFVGA RRELN-E-------LHRLFQRQ-QF------------------QERVS---SDAVRDLIE ----FKFIPARSPNFGGLWEAAVKSLKGHMRRVIG--N-----RML----KFDEF----- --YTV-----VTQIEACLNSRP--------LTP------------L-------------- ----------------------SN--------DPR--D-------L-------------- ----------- >416/1-553 ---ATKRAILSKISQLFDPLGLIAPIVVRGKMLMQE-LWLI-S----------C------ -SWDD-E-VPD--QIKRKWQLLCEQLPLLS---K-FRVD--RYA--F------------- --QP-N-ST---I-QLHT-FADASEA-AYG-ACVYAR--SEST-EG------DISV-Q-- LLAA---------------------------KSRV-APL-------K------------- ---R----------------------------LSIPRLELCATV-VAS-QLHAKIVEA-- -L-Q----M-E-I---DAS---FF---------WS------------------------- -------------------------------------CFLPHHPV-------IKES-STT TKT-RVVFDGSSRTS-SG---FSLNQALCVGPVVQ--DELMDLVIRNR---KFPV--AMT ADVEKMYRQVLVHPK--DTPLQK-----I------KYRFQ---P-TD---------PL-Q SYELLTVTYGLAPSSFLATRT-LHQV------------A----EDE-ANTY--P-LAAPA V-KKS--FYVDDY-IGGAN-S---VSEAIALREELT-EM-LAKG-------GFPLR-KWT SNKL-EV-LRGLPADQIGTQS--T-Y-RFD---------------------------P-- -EETV-----------------KT--LG-------------------------------- -----IMW---------------------------------------------------- ----------------------------------------------------------TV NRPFAISGVDYAGPVY-------------------------------------------- ----------------------------LKAI--HKRA---APT------KA-YIC---L -FVCFT--TKAVHLELVGDLSTSAF-----ISALRRF-VARR-GRPSDLYSDNGKNFVGA KNELH-E-------LYKMLSND-AE------------------VNRIT---AVCIEDGIV ----WHLNPPKAPHFGGLWEAAIKVAKKHLHRQLG--S-----SRL----CYEDL----- --STV-----LTEIEAAMNSRP--------LVP------------M-------------- ----------------------TE--------DPN--D-------F-------------- ----------- >417/1-551 ---WTKRIVLSEISSLFDPCGFLGPIITLCKLVMQD-VWVR-A----------L------ -TWDQ-P-LPV--ELSLRWRLIRVQLPAIS---K-MRKK--RCL--I------------- --AP-D-AV--NV-QLHG-FSDASKR-AYG-GVLYIR--SVNK-CG------EISV-C-- RAAS---------------------------KSRV-APL-------K------------- ---E----------------------------QTIPRLEACGAK-LLA-ELTQKVMAA-- -L-E----V-P-F---DDV---VL---------HC------------------------- ------------------------------GG-----YYIPHHAV-------YKAS-SST TKT-RVVFDASAKTT-SG---LSLNDTLDVGPTVQ--NDLLSIILKFC---THPV--VLT ADIPKMYRQVKLHQD--DCKYQR-----I------LWLDD---D-RQ----------L-K VYELQTVTYGLASSPHHATRA-LVQL------------A----TDE-GKDL--P-LAARV V-KRD--SYVDDF-LTGGS-S---VAEVVQIYKELT-EL-LRRG-------GFGVH-KFC SNST-EV-LRAIPSELHEKQV------DFG---------------------------ESD VNNTI-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------NP APPFSKVGIDYAGPFM-------------------------------------------- ----------------------------LK--TGGRGS---RLQ------KA-YVV---V -FVCMV--VKAIHFELVTNLSTDNF-----IAALQRF-ASRR-GLPSDIHSDNATCFAGG NNELA-A-------LRELFNSQ-LH------------------KNKLE---EFCSLKGIR ----WHFIPPRSPHFGGIWEAGVKSMKHHMKRVVG--E-----TKL----TYEEM----- --TTF-----LAQTEAILNSRP--------LCP------------M-------------- ----------------------SE------------------------------------ ----------- >418/1-559 ----TKALILSELSQLFDPTGMAGPVIVRAKMFLQS-LWEK-N----------F------ -GWTQ-E-LPE--EYQEWWKQYRIEIRVLS---M-LKIP--RRV--L------------- --ID----HSVVI-ELHC-FSDASDK-AYG-ACVYVK--STNS-YG------RSKV-N-- LLIS---------------------------KSRV-CPR-------R------------- ---R----------------------------LTIPRLELCAAL-LGA-QLTAAVLEA-- -T-N----L-S-----CPV---VY---------WS------------------------- ------------------------------PDLSKPHFYLPHHAI-------QRPE-STT TKT-RVVFDASCRSS-NN---ISLNDLCYIGPTVQ--PPLLDTILRFR---LPKY--VVT ADAEKMYRQVLVHPD--DRPLQQ-----I------LWRST---P-NE---------DL-K TYQLNTVTYGTAPAPYLATRV-LNQL------------A----DDE-AENY--P-LAAPQ V-KRS--FYVDDY-LSGDN-D---ENRLMETNRQLI-GL-LGSG-------GFTMR-KWC SNSS-RV-LSHIPEELRDPRT------ELE----------------------------LS ESGSI-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------VP SRAFASSGVDYCGPFA-------------------------------------------- ----------------------------VRPP--NRRG---ASV------KV-FVA---I -VVCMW--SKAVHIDMVYDLTSASF-----INVLKRL-VGRR-GRVTDLYCDNARTFVGA NRHLE-E-------LRRAFDAM-HS------------------SDAVA---AHCAEKGIT ----FHFNPARSPHHGGLWEAAVKSFKHHLYRVMK--D-----TLL----TIDDF----- --NTL-----IVQIEGVLNSRP--------LTP------------L-------------- ----------------------SS--------DPT--D-------V-------------- ----------- >419/1-543 ----TKQKLFSIVASLFDPLGFIGPVITRAKIMMQL-SWSL-L----------D-ENGHK LTWTS-P-LPT--RIEAEFRKFYEQIPRLN---E-LRIK--RVV--V------------- --IP-G-AV--VI-QLHF-FSDASEK-ALG-AVAYVR--SEDS-IG------HILV-A-- PLMS---------------------------KSRV-APL-------K------------- ---T----------------------------QSIPKLELRGTT-LAA-EMYVEVMES-- -L-ELCHLS-P------EI---FF---------WT------------------------- ------------------------------EEEGADRFYLPHHPV-------VREA-STT TRV-RVVFDASAKTS-TN---LSVNDCLLSGPIIQ--RSLRSIILRSR---FRPI--MVV ADIEKMFRQVDVCPE--DRRFQS-----I------LWRPT---P-DQ---------PL-A TYEMSTVTYGTKPAPFLATRT-LVQL------------A----DDE-AERY--P-LASAA V-KED--FYMDDA-ITGAD-D---PITAKQLRVELQ-EM-LNSG-------GFKLR-KFA SNCP-EV-LEGLPN---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VP SKPFSTTGVDYFGPIY-------------------------------------------- ----------------------------VRPG--YRRA---A-V------KA-YVA---V -FVCFS--TKAVHLELVTDLSTACF-----IQALRRF-ISRR-GKCAKLFSDNGTNFVGA RNQLE-D-------LFKLLRSK-EH------------------REAVS---RWCADDGMQ ----WSFIPPGAPHFGGLWESAVRAAKVHLLKVLG--D-----TAV----SYEDM----- --ATL-----LCQVECCLNSRP--------LTQ------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >42/1-554 ---PTKRNVLSVLMSVFDPLGLVTCVTMYLKILLQD-VWRS-K----------I------ -DWDE-Q-IPP--DLQDMWQSWLSFLPLIE---G-TKIP--RCY--F------------- -KNWHAH--DCRV-QIHV-FVDAGED-AYS-AVAYFR--IVEQ-NN------QILL-S-- LVSA---------------------------KSKV-APL--Q-P---------------- --------------------------------LSIPRLELQAAV-TGA-RLMKNIIAQ-- -H------E-IDF---EEC---YL---------WT------------------------- -----------------------------------NAWYLPIFTV-------RNPH-K-P DRV-RLVWDAAAQ-S-SG---VALNDFLLTGPDLL--VPLLQIMYNFR---MRAI--GVS GDIAEMFHRIAVREE--DAKAQR-----F------LWQNQ---TT-----------GVIE TFQLNVLTFGATCSPCIAHYV-RDLN------------A----KKH-ADEF--P-SAAKA I-QRS--HYVDDY-IDSCH-S---EEEAITLAKEVR-EV-HAKG-------GFHMR-KWC SNSK-RV-LAAL--RD----------TLTYEE-----------------------S--QF MICEE-----------------IH--VK-------------------------------- -----LGW---------------------------------------------------- ----------------------------------------------------------AF KPAFTYVGVDYFGPLT-------------------------------------------- ----------------------------VI--DG-R-----K-SRSKHLLKR-WGM---L -ITCLT--MRAISIEIVHSLTTNSC-----LMGLRRH-ISRR-GTPKEIYSDNGTNFRGT DAFLR-D-------KLQDLDDA-K----------------------MH---RELSQQKIS ----WYFNPPSAPHMGGAWERLVRSVKTVLYRILT--V---N-QKF----SDESL----- --LTA-----MAEVEMTVNSRP--------LIY------------V-------------- ------------------SDDGPN-------------DI--------------------- ----------- >420/1-558 ---PTKRQALRIVMSLFDPAGLLCFFIIHGKILIQE-VWRA-K----------T------ -EWDQ-K-IPD--KLKERWMRWIAMFKHLS---E-VRIP--RCY--F------------- -SKYSIA-DIVSL-QLHV-FCDASEE-AYS-CVAYFR--AVYF-DG------TIQV-A-- LIGG---------------------------KAKV-APL--K-A---------------- --------------------------------LSIPRLELNGAV-IGV-RLRKSITNG-- -H------S-LKI---DKT---VM---------WT------------------------- ---------------P---------------------WYLPLGVV-------LNPK-K-P SKI-RIFCDAAAK-V-XG---ISLNTMLLKGPDLL--KTLLHVLFGFR---EKRV--ALC ADIKEMFHQVQIRRE--DRHAQR-----L------LWRDD---P-SK---------X-PE VYLMDVATFGATCSPCSAQYV-KNRN------------A----EEH-AXEY--P-EAADA I-IRK--HYVDDY-LDSAD-T---VEEATKLALEVK-HV-HSLG-------GFXLR-NWL SNSK-XV-LARV--GE-SDXA----LEKCIQL-----------------------D-KND PT--E-----------------RV--LG-------------------------------- -----MFWKPEEDVFTYTM----------------------------------------- ----------------------------------------------------------AF ERPFSCTGIDYFGPIA-------------------------------------------- ----------------------------VR--VN-R-----S-TP-----KR-WIA---L -FTCLT--TRAVHLEVVHTLTTESC-----KQAIRRF-IGRR-GAPAEIRTDRGTNFVGA NNELR-L-E------MNK-LDG-Q----------------------LA---ETFTNTNTR ----WVFNPPAAPHMGGAWERLVRSVKTALAA-MY--T---S-RVP----NEETL----- --ATL-----LVEAESIVNSRP--------LTF------------I-------------- ----------------------PL-------------QS--------------------- ----------- >421/1-552 ---PTKRIVLSCVMGFFDPLGLLAVFTVHGKILVQD-LWRT-G----------C------ -AWDD-T-VNE--DCWKKWKRWIGLLPEVE---A-IRIQ--RCY--F------------- -GEVPWS-SVESV-ELHI-FTDASEL-AYG-CVGYLR--TVVE-GF-------VRC-C-- LIMS---------------------------RSKV-APL--K-R---------------- --------------------------------QSIPRLELMGAV-MGA-RMLHSIIST-- -H------S-IKF---QRY---VL---------WS------------------------- ---------------A---------------TDPNKVWYLPLNVV-------LNPR-K-P DKI-RLVWDAAAT-V-NG---VSLNSQLLTGPDLL--TPLISVVTRFR---EHRI--AFG ADIREMYHQLRIIEA--DKQAQR-----F------VFRMS---K-ED---------P-IN IYVMDVATFGSTCSPCSAQYV-KNQN------------A----LEY-AEEY--P-AAAAA I-IDG--HYVDDY-FDSVD-T---IDEAIERAKEVS-FV-HAQG-------GFELR-NWV SNSP-DV-LRSL--GE-----VTETKPIHLGR-----------------------V-KET GS--E-----------------RV--LG-------------------------------- -----IIW---------------------------------------------------- ----------------------------------------------------------PQ LRPFCAVGVDYLGPIE-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WIA---L -FTCLT--VRAVHLEIAYSLSSQSC-----LMAIRRF-ICRR-GRPEEFFSDNGTNFTGA SKEL-----------LKQ-IDG-D----------------------CA---EAVTSSATK ----WNFNPPGAPHMGGIWERMVKSVKEAMTV-LN--D---G-RKL----TDEIL----- --TTT-----MSEAEDMINTRP--------LTY------------R----SLE------- ----------------------PA-------------ET--------------------- ----------- >422/1-548 ----TKAKILSIIAKIFDPLGLVGPVVAKAKIFMQG-IWEL------------KNAKGKP WDWND-P-LPK--SMLDEWMQFYEQLHYLN---N-LRIP--RFA---------------- -----MIPNPVHI-QLHF-CSDASEK-ALG-ANLYIR--SEDK-EG------RVKV-S-- FFTS---------------------------KSRV-APL--K-R---------------- --------------------------------QPIPRLELNGFW-LAA-DMYRKFKEC-- -T------T-FRF----ET---FF---------WT------------------------- -------------------------------------------------------S-STT TRV-RVVFDASSKTS-TG---TSLNDVLLNGPVIQ--DDLRTIISRSR---LFPI--LLV ADVEKMFRQIRMDAE--DLPLQR-----I------RWRFS---E-DD---------PI-D TYELLTVTYGTKPAPFLATRT-LKQL------------S----VDD-ATKY--P-LAAVR I-ARD--VYMDDV-ITGAY-H---PAEAKQIREQLD-TM-TLGA-------GFPLR-KWV SNCE-EA-LEGVSEDNLALPREKG-I-DFD---------------------------E-- -ERTV-----------------KT--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------IA ARPFTNTGVDYFGPVY-------------------------------------------- ----------------------------IRQG--YRRG---P-V------KA-YVA---V -FVCFG--TKAVHLELVSDLSTAKF-----LQALRRF-VARR-GKPADMYSDNGTNFVGA KNDLK-D-------LLHNLRHE-KH------------------HEHIQ---HECSQEGIN ----WHFIPPGAPHFGGLWEAAVKSAKKHLLRVVG--Q-----SSI----SHEDY----- --ITL-----LAQVEACLNSRP--------LTP------------L-------------- ----------------------TE--------DPS--D-------L-------------- ----------- >423/1-557 ---PTKRQVLRLVMSLFDPCGLIAHFIIHGKILMQH-IWRS-G----------T------ -DWDE-S-IGD--GLRDLWHHWTRLLSQLI---E-VKVP--RCF--F------------- -GYSSSK-LHNGI-QLHV-FVDASEL-AYA-CVVYLR--ILQ--DG------VVRC-V-- LVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAGL-IGC-RLMESICAA-- -L------N-LPL---EKR---CL---------WT------------------------- -------------------------------------WYLPLGIV-------RNPK-K-P GKI-RLIWDAAAR-V-NG---VSFNDMLLKGPDML--TSLFAVLLRFR---QRPV--AVC GDIREMFHQVRIITQ--DKQSQR-----F------IYREH---R-DQ---------T-PQ VFIMDVATFGATCSPCSAQHV-KNTN------------A----KDF-APHF--P-KAAEA I-INA--HYVDDY-LDSVD-T---IEEAVQLVEEVK-YV-HAQG-------GFHIR-NFA SNSP-EV-LQRL--GQ-TKCL----NEKSMIL-----------------------D-XIT DT--E-----------------RV--LG-------------------------------- -----MMW---------------------------------------------------- ----------------------------------------------------------PH IRPFCYTGVDYFGPLQ-------------------------------------------- ----------------------------VK--QG-R-----S-LA-----KR-WVA---L -FTCLT--TRAVHLEIVHSLSTQSC-----VMAIRRF-GARR-GFPTDFYSDNGTCFRGA CNLLK-E-Q------IDA-IHE-D----------------------CA---VTFTNARTS ----WHFNPPSAPHMGGSWERMVRSVKAAMGVIAE--Y---P-RHP----SDEIL----- --ETV-----VLEAEAIVNSRP--------LTY------------V-------------- ----------------------PL-------------DDPEQEALTPNHF---------- ----------- >424/1-534 ---FTKQTVLSDTARIFDPVGLVGPVVVIAKIFLQK-LWKK-G----------I------ -DWKE-P-LPE--NLVHIWEEFRRNMMSFD---N-IAVP--RWV--G------------- --FSLQ-CV--KL-ELHG-FCDASLE-AYG-ACFYTR--STWS-NG------GVSV-N-- LLTS---------------------------KTKV-APM--T-DLKR------------- ---RTKE-------------------------ETIPRLECSSGL-LMC-HLLQKIRPL-- -F-P----V---D---IEI---HL---------WT------------------------- -----------------------------------QAYYLPHHAV-------LRPD-STT TKL-RVVFDASCATS-SG---VSLNDALMVGPVVQ--DDLLTIILRFR---LRKI--AVV ADVAKMYRMVNVHPD--DQDLQR-----I------LWRDS---P-SE---------PV-R TFKLTTVTYGTASAPYLATKC-LRTV------------G----EEV-ETTH--P-LAAKT I-KHD--FYVDDM-LSGAD-S---IEEAQKLVGETS-ER-LMAA-------GFLLR-KWR SSDN-AV-L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------NP APPFLKTGVDYCGPFQ-------------------------------------------- ----------------------------LSYP--GRKA---RPV------RC-FVA---V -FVCLV--TKAVHLEVVTDLTTQAF-----LAALKRF-TARR-GKPQLIMCDNAKTFVGA KRELD-D-------LAKLFCDQ-QF------------------HEAVV---RDAAKESIE ----FKFIPPRSPNFGGLWEAAVKSFKTHFKKTIG--L-----RVL----QHDEF----- --VTV-----LVQIEACLNSRP--------LTP------------L-------------- ----------------------SS--------DPN--D-------L-------------- ----------- >425/1-558 ---WTKQQVLSEIAKLFDPLGLLGPTVALAKMVMQE-TWRS-G----------I------ -GWND-V-LPP--PLMARWRKLRNALAELA---E-IKIP--RRV--T------------- --TD-D-AR--SW-ELHG-YADASAK-AYG-CSIYLR--NVKV-DG------TEEL-F-- LLCG---------------------------KSRV-TPV-------K------------- ---EAERKQKDDAEPAD---------------MTMPRLEACAAE-LLA-EQIVKVVKA-- -I-D----I-P-I---DRV---VL---------WS------------------------- -----------------------------------------------------RPD-SST TKL-RVVFDASARST-TG---HSLNDTMMIGPPVQ--DTLFEILLRFR---LHKY--AFT ADVPKMYRQVRVSPE--DTKFQR-----I------VWRDD---R-SK---------PL-E VIELMTVTYGTAAAPFLATRA-LNQL------------A----ADE-KEDY--P-EASKV V-SSS--FYVDDV-LSGAA-T---IEKAKQLQSDLA-AL-LARG-------GFELH-KWC ANDA-AL-LEDIPIAKQEKQL------DFE---------------------------NHD AKDTV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TV AEPFARTGVDYAGPVM-------------------------------------------- ----------------------------LK--QGRLKA---P-V------KG-YIA---V -FVCLC--TKAIHLELVTSMSTEAF-----LAALHRF-VSRR-GNVSEMKSDNGTNFIGA ARELT-E-------LAELLRSQ-ML------------------ERKLD---EFCQARSID ----WSFNPPKAPHQGGLWEAGVKSAKHHLYRVLN--E-----SHL----TYEEM----- --NTL-----LIQIEAVLNSRP--------LCQ------------Q-------------- ----------------------TD--------DPL--D-------Y-------------- ----------- >426/1-530 ---PTKQQALSIVMSIYDPTGFLAAFIVHGKIILQD-VWRS-R----------V------ -DWKQ-K-IPD--ELFQRWRQWIALLPKIE---D-LKIP--RCY--F------------- -PGYHPD-SLRSL-ELHV-FVDASES-AYS-AVAHFR--LVD--RK------RVRC-A-- FVSS---------------------------KTKV-APL--E-P---------------- --------------------------------LSIPRLEANAGV-LGV-RLRKSIVTG-- -H------S-LPI---TRT---RF---------WT------------------------- ---------------R---------------FDPRRTWYLPLGVV-------INPN-K-P GKV-RLIWDAAAK-V-EG---VSLNSMLLKGPDLL--SPLMSVLFKFR---ERQV--AIG GDIEAMFHQVLIREA--DRSAQL-----F------YWRDS---P-EK---------P-LE TMVTDVAIFGASCSPAHSQYV-KNLN------------A----TEH-EAEF--P-RAADA I-RTK--HYVDDY-LDSVD-T---AEEAAAIALEVA-DV-HAKA-------GFHIR-NWV SNDD-SV-LQKI--GT-----VN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF LRPFTFTGVDYFGPYL-------------------------------------------- ----------------------------IK--VG-R-----S-VA-----KR-WVA---L -FTCLT--IRAVHLEVVAGLSTDSF-----KKAMRRF-IARR-GAPQEIYSDRGTNFIGA SGELA-K-E------IVLNINQ-E----------------------LS---STFTDAHTQ ----WRFNPPAAPHMGGSWERMVRSVKVALGA-IP--T---Q-RKL----DEESL----- --VTM-----LTEAEYMVNSRP--------LTF------------I-------------- ----------------------PL-------------EN--------------------- ----------- >427/1-552 ---PTKRNILRCVMSLFDSQGLLSHITIQGRMIIQD-TWRG-K----------T------ -NWDD-E-VIE--TIRVRWLRWTQLFKKVG---E-IRLN--RAY--F------------- -PGFSAA-EIGAV-ELHV-FTDASEE-AYA-CTAYFR--VVI--NG------KVYV-T-- LAMA---------------------------KAKV-APL--K-A---------------- --------------------------------LSVPRLELMGAL-LGA-RLAKAVMEY-- -H------S-FPI---CRR---VF---------WT------------------------- ---------------S---------------ANPHKIWYLPLGAV-------RNPK-K-P GKI-RLIWDASAK-V-GN---VSLNAMLLKGPDLL--TPLASVLCGFR---ERPV--AVC GDLRQMFHQFRIRSE--DVHSQR-----F------LYREH---F-TE---------P-VK VFAMDVGSFGATCSPCQAQYI-KNLN------------A----REH-EKEF--P-EAAKA V-INK--HYVDDY-LDSFD-T---EAEAIKVALDVK-EL-HSRG-------GFEIR-NWH SNSE-AL-LARV--GE-PKKV----STRAISI-----------------------D-SES EA--E-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------AG VRPFSYVGLDYFGPIH-------------------------------------------- ----------------------------VR--VG-R-----S-SV-----KR-WVA---L -FTCLT--VRAVHLEVVHSLSTESC-----KMAVRRF-VARR-GSPVEIHSDNGTNFQGA SRELK-D-E------IEV-IGQ-N----------------------LA---ETFTNSNTK ----WLFIPPSAPHFGGSWERLVRSVKVALRS-LC--S---D-RNP----DDETL----- --LTV-----LAEAESVVNSRP--------LTK------------I-------------- ----------------------PL-------------ES--------------------- ----------- >428/1-561 ---PTKRNILSVIAQLYDPLGLIAPVVVLAKIVLQE-LWYL-A----------L------ -EWDA-L-VPP--ELRTRWFDFCEGLSHLT---N-FRID--RYA--F------------- --AR-K-CC--YA-ELHF-FSDASEV-AYG-AVAYVR--SESP-DG------KIKV-S-- LLTS---------------------------KSKV-APL-------K------------- ---K----------------------------RSIPRLELCAFF-LAA-QMYVRVVEA-- -L-D----V-K-F---QDV---YF---------WT------------------------- ------------------------------EDETSRACYLPHHPV-------IKEQ-SST TKV-RVVFDGSAKTS-AG---HSLNDALLVGPVVQ--DELLDTVLRFR---KFPI--ALV ADIEKMYRQVAVHPE--DRPYQR-----I------VWRFD---P-EQ---------PI-T TYELATVTYGLAPSSFLATRT-LLQL------------A----DDE-GAQF--P-QASAA I-KKH--MYVDDF-IGGAQ-T---VDDAILLRSDLC-KL-LLKG-------GFQLR-KWC SNSL-AV-LADIPSELLGTQS--S-L-QFD---------------------------P-- -EETI-----------------KT--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------TA NEAFTCTGVDFCGPLY-------------------------------------------- ----------------------------LKPT--HRRA---ASR------KC-YVA---V -FICLS--TKAVHLELVNDLSTAAF-----LMALTRF-TWRR-NKPSHIYSDNGTNFIGA KNVLH-Q-------LYQMLQPG-PE------------------SDKIA---KHLADDGIQ ----WHLIPPRAPNFGGLWEAAVKVAKKHLVRQLG--N-----SLL----SFEEL----- --TTV-----LTAIEGCMNSRP--------LTR------------L-------------- ----------------------SE--------DPN--D-------L-------------- ----------- >429/1-551 ----TKRLVVSDTARLFDPQGLVGPVILRSKTFVQQ-LWKA-K----------V------ -AWDR-I-LSE--KQQQYWKEFRTDLDALN---T-FTVP--RWA--A------------- --PGSQ-PV--ET-QLHI-FCDASEL-GYG-ACAYLR--TESG-NG------TVSV-N-- LLTA---------------------------KSRV-VSL--------------------- ---SKQ--------------------------INLPRLELCGAL-LAA-HLYEKIAPN-- -L-P----P---N---IRV---FF---------WT------------------------- -----------------------------------KPYYMPHHCI-------ERPE-STT TKL-RVVFDASCATD-TG---ITLNDALAVGPVVQ--DDLFSLILRFR---LEPF--VLV ADIEKMYRQVLVHPD--DRHLQR-----I------LYRES---P-TE---------PL-Q TYELRTVTYGTASAPFLATRC-LKQL------------A----LEE-EHRF--P-EAAKV L-ARD--FYMDDL-LCGVE-T---AREGIELSRQLI-EL-LGSA-------GFKLC-KWA SNSS-TI-LQNIPAELRENRS--E-F-ELD---------------------------S-- SSAPI-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ------------------------------------------------------------ ----LNSGVDFCGPFY-------------------------------------------- ----------------------------LRPP--HRKA---APQ------KC-FVA---V -FVCMA--TKAVHLELVGDLSADSF-----IAALKRF-AARR-GVPKTLFCDNGTNFVGA RRTLN-E-------FVRLLKTQ-QV------------------QDQVV---RSCSADGIQ ----FQFIPPRTPHFGGIWEAAVKSLKNHLRRTVG--N-----ANL----TAEQM----- --STF-----LAQAEACLNSRP--------LTP------------I-------------- ----------------------SN--------NPD--D-------L-------------- ----------- >43/1-553 ---FTKRSILSVVARMFDLLGFISPVIVRCKILMQD-LTLK-G----------L------ -DWDE-P-VDG--RIKERWKELLQDLKDLS---N-LQIP--RYVNT-------------- -------SKTYRC-EIHG-FADASER-AYG-CCLYVR--SELPSGV------K--V-T-- LLVA---------------------------KSKI-APT--K-T---------------- --------------------------------QSLPKLELCGAL-LLS-RTWRKF--E-- -R------T-LKLYI-DKV---YF---------WT------------------------- --------------------------------ANEPHYYIPHHCV-------LRPQ-SVT TKL-RVVFDASAKTS-SG---KSLNELLMIGPTIQ--QDLFITFLSFR---LNRY--ALT GDIAKMYRQFVIDPR--DRRFQR-----I------VWRPT---K-TE---------EL-K TYELNTVTYGMSAAPFLAIRG-VHHI------------A----DLY-SHDH--P-IGAKT L-RND--LYVDDL-LTGAD-S---VTELQHIKNDTV-DI-LAQA-------GLHLT-KFS SNCK-EI-TKTSEDEVFIAME--------------------------------------- DQDTT-----------------KT--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------RA ERPFLVTGVDFCGPFF-------------------------------------------- ----------------------------TSYR--IRGK---PPY------KT-YAA---I -FVCFA--SKAIHIELVSELSTNAF-----LLCIRRF-VARR-GVPLRMVCDNATNFVGA ATRLA-E-------FKSKLFNS-DV------------------IDHIK---TYSSIKGFN ----FCFIPPRAPHFGGLWEASVKSAKTLALKNIS--N-----ASL----TFEEL----- --LTV-----FSDVEAILNSRP--------IAP------------T-------------- ----------------------SD--------DPN--D-------F-------------- ----------- >430/1-547 ---PTKREVLRVVMSLFDPLGFVAYFLVHGKVLMQD-IWAS-G----------I------ -DWDD-K-IGE--ELFLRWQQWIRYFPQLD---N-IRIP--RCY--F------------- -HSPFPA-DFDRL-ELHV-LVDASDS-AYA-CVAYYR--LET--ES------GVQV-V-- LIGA---------------------------KTKV-APL--K-A---------------- --------------------------------LSIPRLELNAAI-LGS-RLLDTIQGY-- -H------T-YPI---NRR---FL---------WS------------------------- -------------------------------------WFLPLGVV-------VNPK-K-P GKL-RIIWDAAAK-V-DG---VSFNSHLMKGPDLL--TPLPRVLSGFR---LYPV--AVS GDIREMFLQIGLQAS--DRNAQM-----F------LFRDH---P-QD---------P-VQ IYAVNVTMFGSTCSPSSAQYV-KNVN------------A----EQH-ALHY--P-RAATA I-IEH--HYVDDY-LDSFR-T---VDEAVQIVRDVK-FV-HSRG-------GFEIR-NFL SNKD-EV-LRRT--GDI----ETNT-SKEFAL-----------------------V-RAE TT--E-----------------SV--LG-------------------------------- -----MKW---------------------------------------------------- ----------------------------------------------------------PF VRPFTFVGLDYFGPVL-------------------------------------------- ----------------------------VR--VG-R-----S-QV-----KR-WVA---L -FTCLT--IRAVHLELVHSLSTESC-----IMAVRRF-IARR-GPPAEFYTDNGTCFQGA SNQLE-KEK------TEA-RNN-S----------------------LA---AKFTSSKTQ ----WRFIPPAAPHMGGAWERLVRSVKVALGSVAE--A---S-RIP----DDEVL----- --ETA-----LLEAEALINARP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >431/1-548 ---PTKKEVVRVLMSIFDPLGLLANVLMFLKVLIQE-IWRS-G----------I------ -GWNA-T-ITP--EQYEKWLVWLKVIEKVE---A-VSIP--RCY--R------------- -QITSSS-SKTNV-QLHT-FVDASTN-GCA-TVAFLR--FEE--ED------RIEC-A-- FVAG---------------------------KTRV-APN--K-L---------------- --------------------------------TSIPRLEIDAGT-MGV-RLAQKIMEG-- -L------R-IVI---HQR---FF---------WT------------------------- -----------------------------------RVWYLPIFVV-------TNPN-K-P GKL-RIVWDAAAE-V-RG---ISLNSVLLKGPDQV--TSLVDVLLRFR---EYRT--AVT GDIKEMFHQVRVHPD--DQHCQR-----F------LWNNG---A-PG---------STPS VYVMQVMTFGASCSPSCAQFV-KNIN------------A----ERF-AEDS--P-AAAKA I-IND--HYVDDM-LSSVE-T---EQEAIKLASSVR-DI-HGQG-------GFEIR-GWR SNSK-AV-LAAL--NS---QECE---DKNLSE-----------------------ASQ-F ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TRPFSYTGVDYFGPIS-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -LTCLV--TRAVHIEIAHTLTTDSC-----ILALRNF-MAIR-GTPLELISDQGTNFIGA DRELK-K-------AYQKVDQN-Q----------------------LI---REFTTTNTK ----WTFNPPSSPHMGGSWERLVQSVKKVLNQMKL------P-RNP----SDEVL----- --RNT-----LLEISNIVNSRP--------LTY------------I-------------- ----------------------PV-------------ED--------------------- ----------- >436/1-570 ---NTKRAILSNVARIYDPLGWLAPMVLIAKLTLQE-LWRL-Q----------L------ -DWDE-T-VPS--DMLSQWHLFTSEFHYLK---D-IKIP--RLI--V------------- -PPHSK-----SY-ELVG-FCDGSTK-AYG-CSVYLR---ITT-DS------EITS-H-- LLIA---------------------------KSKV-APL-------K------------- ---V----------------------------LTVNRLELCSAV-LLA-KILKHISNL-- -LNETQTSN-ITI---SKI---WA---------FT------------------------- ---------------------------------------IPHHCV-------IRPE-STT TKL-RVVFDASAKTT-NG---KSLNDLVYTGPKLQ--NDIGDILTKFR---LHAV--VFT ADISKMYRNIELRPE--DRKWQH-----I------LWRDS---P-SD---------PI-T EYELKTVTYGVTSSPYLAIRT-LHQL------------A----SDY-EKEW--P-LAAAS L-RHD--TFMDDI-TVGAT-S---IETALKHKEELI-QM-LARA-------KFELR-KWS SNSP-EF-LTQIPTEHCQVPKRPS---------------------------------GVV VSDMV-----------------TT--LG-------------------------------- -----GRGFESRQGKIFVXXI--------------------------------------- ----------------------------------------------------------QA ARCFQNIGVDFAGPFI-------------------------------------------- ----------------------------VKES--RRRN---AKTY-----KT-YAC---I -FVCLA--VKAIHIELVTELSTSAF-----IAALDRF-VSRR-GLCSTIISDCGSNFVGA KRYLS-E-------MHQLMLSK-NL--------------------EVE---SILINRGIQ ----WKLNPPTGSHFGGIFESGVKSMKYHLKRVIG--S-----QIL----SFEEL----- --TTI-----LTKIEAILNSRP--------LIS------------V-------------- ----------------------SS--------D-----------------PNEV------ ----------- >438/1-533 ----TKRNVLKIIASIYDPIGIISPLILPLKLIFQK-ICTT-I----------K------ -DWDK-E-LND--ELKNEWNQ-LMQLLSCN---L-V-YEWHRYF--F------------- -KEHLIK-NLTNI-TIHG-FCDASKS-AYA-AVVFIT--AQTP-DK------QILG-R-- LIAS---------------------------KTKI-SPL--K-P---------------- --------------------------------ISIPKLELSSCL-LLS-SLMACVIES-- -L------N-STLKI-ENI---YC---------WS------------------------- -------------------------------------HYLPHHAV-------IKE-EKST TKL-RIVFDASS-----N--SPLLNDCLEKGPCLL--PMLIDILIRFG---TYKI--AVA SDIKKAFLNIAVNKN--DRDFLR-----F------LWFDN---V-NNSN------PKV-I SYRYTRVLFGMNSSQFLLLVS-IMKH------------L----YQYKHCDP--E-FV-NN F-LIN--LYVDDS-IARGD-T---SNEVLEFCLKAK-XR-LKTA-------GLNLK-KWR SNNS-RL-ISNISSFNPQDHP--------------------------------------- STES------------------KI--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------TA SFPFQHTGVDYLGPLH-------------------------------------------- ----------------------------VKPIFDDNST---EMY------PV-HVV---L -FTCAT--TRAVHLDLVPDLSAKSF-----ILCLKRF-IGRR-GIPNLIISDNATCFKN- --------------------------------------------EEVK-LSEELLLLGID ----WKYIIEAAPWWGGFWERLVQSVKKSLLKVVF--R-----SSI----RYDEL----- --ETI-----LCEIEGLLNSRP--------IT---------------------------- ---------------------------------------------------YAY------ ----------- >44/1-557 ---FTKRSIFSEIGRLFDPIGFLSPVIVVAKLYMQK-LWLI-E----------L------ -PWDA-K-VEG--DLLASWLCFRRALPKVS---E-IRIP--RYV--I------------- --SP-S-TV--AI-ELHG-FSDASVV-AYG-ANIYVR--CILS-DG------RAQL-R-- LLCS---------------------------KSRVCSPK-------K------------- ---D----------------------------LNIHRKELMACE-LLA-RMMVRVLET-- -V-K----F-K-V---SQV---VL---------WT------------------------- ------------------------------HR-----YYMPHHAV-------LRPT-SST TKL-RVVFDASAKQGSTA---KSLNEVLHVGKPVQ--SDLFSILLRFR---KNPI--AFT ADIEKMYRQVLIDSS--QTRFQR-----I------LWRSD---S-SK---------PI-R VLELQTVTYGTAAAPFLSTRC-LVQL------------C----QDE-REKF--P-LAAEV V-RDD--CYVDDI-LSGAS-S---ADEAVVVQRQIR-KM-LESG-------GFRVH-KWS SNCQ-EV-LSSVPESDREKLV------CLD---------------------------Q-- GNEVV-----------------KA--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------NQ ALPFEVTGVDYAGPVY-------------------------------------------- ----------------------------VK--EGRYKP---KIV------KA-YIS---V -FVCMV--TRAVHLELVSDMSTETF-----LAALKRF-VGRR-GLPREIHSDNGTNFRGA KTELH-E-------LYELLKSQ-VT------------------VDEIA---QFCQPREIN ----WSFIPPEAPNFGGIWEAAVKSTKFHLKRTLK--E-----AKL----SFEEY----- --ATV-----LTQIEGILNSRP--------LYA------------T-------------- ----------------------SS--------EPN--D-------S-------------- ----------- >440/1-545 ---PTKRELLRLVMSIYDPLGLVASFVIQGKILIQE-VWRT-E----------T------ -GWDC-Q-IPL--EIAPRWTEWISVLKKMD---G-LRIP--RCY--F------------- -PGYDPE-SFKNL-ELHV-FVDASAQ-AFA-AVAYFR--IID--RG------QIRV-A-- LVSS---------------------------KTKV-APL--R-A---------------- --------------------------------LSIPRLELMAAL-LGV-RLRKTVEKN-- -H------S-LKI---QKT---FF---------WS------------------------- -------------------------------------WFLPIGVV-------VNEK-K-P GKV-RVIWDAAAK-V-DG---VSLNSMLLKGPDLL--TPLLSVLFPYR---ERQV--AVS ADIKEMFLQILIRQQ--DRSALL-----F------PYRES---P-QL---------P-MS IMVSDVAIFGAACSPAHSQYI-KNLN------------A----TEQ-EVEL--P-RGSAA V-KKK--HYVDDY-VDSFD-T---SEEAFEVAKEVI-EV-HRRA-------GFYIR-NWM SSDK-SV-LEKL--GE-----VSQEPSKAMLP-----------------------E-KDI SF--E-----------------RV--LG-------------------------------- -----LAW---------------------------------------------------- ----------------------------------------------------------PG VRPFTYVGVDLFGPYL-------------------------------------------- ----------------------------VK--VG-R-----S-VA-----KR-WVC---L -FTCLT--IRAIHLEVVTSLSTDAC-----KKAIRRF-IARR-GSPLEIYSDNGTNFVGA SRELQ-D-E------IKK-IHT-E----------------------LG---STFTNVQTQ ----WRFNPPAAPHMGGCWERMVRSVKSALGS-VP--V---E-RKL----DDESF----- --ATV-----LAEAESMINSRP--------LTF------------I-------------- ----------------------PL-------------ET--------------------- ----------- >441/1-555 ---WTRRRVYSMVARLFDPLGLLAPVTAWAKIQMQA-LWIA-T----------D------ -DWDE-P-IPT--QMELLWNQFQDQLPRLK---E-IKFA--RHV--V------------- --IS-N-PV--SV-QFHC-FSDASEA-AYG-ACVYLR--SMDG-DG------NVKV-E-- LVAA---------------------------KSRP-APL-------K------------- ---K----------------------------ISLARLELCGAV-LAT-NLRKCVGRA-- -L-K----M-E-E---AET---FM---------WT------------------------- ------------------------------------SFYLPHHPV-------IKRA-STT TKV-RPVFDGSAKTS-NG---VSLNEALLKGPVIQ--DSLLDILLRFR---MKAF--VLV ADIKQMYLQVKVDPK--HTRYQR-----I------LWRED---P-AL---------PI-E VYELQRVTFGLTSSSFLATRV-LKQL------------A----IDE-GDAY--P-RAQQA L-LQD--FYVDDF-LGGAD-N---EEEARQLVDELL-KL-MAKG-------GFHMQ-KWN SNSS-AV-LAQVASDDWSRAN--V-V-KLS---------------------------S-- -EEPV-----------------KT--LG-------------------------------- -----IAW---------------------------------------------------- ----------------------------------------------------------TP SRPFSVVGMDYCGPFY-------------------------------------------- ----------------------------LRPV--HRRA---AAQ------KS-YMA---V -FVCFS--VKAIHLELVEDLSTAAF-----MAAFRRF-VSRR-GLPSKVYSDNGLNFRGA SSELK-E-------LYELLNEP-EN------------------QQRIQ---NAALQDDIE ----WHFIPPHAPNFGGLWEAAVKSAKRILRKVLG--N-----QRL----SFPEM----- --TTV-----LTQIEAQLNSRP--------LTP------------L-------------- ----------------------SE--------DPS--E-------M-------------- ----------- >442/1-569 ---PTKREVLSALAKIFDPLGLISPVIVIAKMLMQE-LWKA-Q----------L------ -GWDD-K-VDD--SLLHGWTKFLAALPREN---Q-IRIP--RQM--V------------- --ND-D-SG--FF-ELHG-FADASDK-AYG-ACVYIR--SVNG-HG------SAEV-R-- LVTS---------------------------KSKV-APL-------K------------- ---P----------------------------TSIPRKELMAAV-LLC-RLTIKVVDA-- -LFR----T-T-F---RSI---NL---------WS------------------------- -------------------------------------WYLPHHAV-------LNPS-KNT TKC-RVVFDASAKV--ND---ISLNDVMMTGPTVQ--ADLFSVQLRFR---MHRY--VLS ADVAKMFRQIKVDPR--DTPLQR-----I------FWRAE---S-SS---------PI-R VFELTTVTYGTAAAPFLATRT-LLQL------------A----DDE-QLRF--P-LASRV V-KEN--FYVDDG-LFGAN-H---VEELLEVQRQIV-QL-FDSA-------GMHLH-KWA SNSE-VL-LSEVPREDRDSFT------VLG---------------------------ESK ANEII-----------------KT--LG-------------------------------- -----IKWNPATDEFIFITPQI-------------------------------------- ----------------------------------------------------------NA APTFERVGLDYAGPIL-------------------------------------------- ----------------------------LR--SGIRRV---SSS------KG-YIC---I -FVCMV--TKGIHLEAVENLTTEAF-----LAAFKRF-VSRR-GIPQEVFSDNGTNFVGA NAEIR-E-------MRKAYKKA-VA------------------AQGFV---EFCQAKEIS ----WKHIPPNAPHFGGIWESGVKSVKAVLKKVYK--T-----ASL----AIFEF----- --YTL-----LCQIEAILNSRP--------LYA------------H-------------- ----------------------SS--------D-----------------PHDL------ ----------- >443/1-550 ---MTKRCLVARIAKLYDPVGILQPVIITAKILMQN-LWRD-N----------L------ -TWDE-T-VPP--HALAKWNEFAAQLPVLR---Q-LHIP--RMA--L------------- -PSEAE-----NS-TIYG-FCDASTK-AYG-CAIYVR--YLDG-NG------ERRS-R-- LLCA---------------------------KSRV-APL-------K------------- ---E----------------------------LTLPRLELQAAL-LLA-ELYVKIRDV-- -F------G-TRV---QQT---RW---------WT------------------------- -----------------------------------VRYVIPHSCV-------IKPD-STT TKL-RVVFDASAKST-TG---ISLNDLQAIGPVIQ--PDLLHLWLHFR---TQTV--VVT ADIAKMYRQIWVADS--DTWMQC-----I------LWRED---A-RD---------TA-Q MYRLRTVTYGEASSSYLACRA-LYEA------------G----EEV-RSSN--P-EIADA I-QRS--FYVDNL-SLGAA-T---PDELRVLSCGIE-RA-LMNR-------GMPLR-KWA SNVP-AV-VHDVPEEHLDSPV------------------------------------QIG DRQAI-----------------KM--LG-------------------------------- -----LAW---------------------------------------------------- ------------------------------------------------------------ --AFTHTGVDLCGPFY-------------------------------------------- ----------------------------VIPH--TRST---RRI------EV-YVC---I -FVCFA--TKAIHLEVVENLSTSAF-----ISALIRF-VSLR-GRPDTIYSDNGRNFVGA AKELR-L-------LREAYNNR-AF------------------QDEIV---NLAAEKGIR ----FSFIPPRSPNFGGLWEANIKVAKRLFKAAAR--G-----AHL----KLVEL----- --QTL-----LYQISSILNSRP--------LTA------------V-------------- ----------------------HAN--------PG--S-------V-------------- ----------- >444/1-553 ---PTKRMVLSRVMALFDPLGLLSPFTVRGRMLVQD-LWRT-G----------C------ -GWDE-C-IDD--ESFQKWQRWSKRLHDIE---T-FKIP--RSY--F------------- -GKNRSD-EIENL-QLHI-FTDASET-AYG-CVAYFR--AVIR-GQ-------IEC-V-- LVMS---------------------------RSKV-APL--K-Q---------------- --------------------------------LSIPRLELQGAV-LGA-RLARTVHEN-- -H------S-YTI---GKQ---FM---------WT------------------------- ---------------E---------------IPSSNVWYLPLNVV-------LNPR-K-P DKI-RLVWDAAAS-V-DG---VSLNSELLKGPDML--VSLPEVISHFR---ERPV--AFG GDIAEMYHQIRIRPE--DKSAQR-----F------LFRTN---P-DK---------D-PQ IFVMDVLTFGSTCSPSSAQFV-KNLN------------A----EQY-TTKF--P-EATNA I-IRR--HYVDDY-FDSTN-T---VDEAIKRAKEVQ-YI-HAKG-------GFCIR-NWV SNSR-AF-LEDM--GE-----REACRKVHFSH-----------------------D-KDN EY--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PN LRPFSYVGVDYIGPFE-------------------------------------------- ----------------------------VS--VG-R-----R-VE-----KR-WIV---L -FTCLV--VRAVHVEVAYSLTTQAC-----LMAIRRF-VCRR-GSPCEYFSDNGTNLKGA SKEIL-S-S------VSN-IGF-D----------------------CA---EEFTTARTK ----WTFNPPAAPHMGGVWERLVRSIKEALEV-LN--D---G-RRL----TDEIL----- --QTS-----IIEAEDMVNSRP--------LTY------------V----SQQS----V- ------------------------------------------------------------ ----------- >445/1-523 ---PTKRTLLSIVMSFFDPLGLYTLFTVFGKMIIQD-LWRN-G----------C------ -SWDE-T-IDA--DSAKKWSRWIALVPQVQ---A-MEIP--RCY--F------------- -SKVKPS-DYQNL-ELHV-FADASEE-AYG-CVAYFR--IFVN-GQ-------PRV-A-- LVSA---------------------------KSKV-APL--Q-Y---------------- --------------------------------TSIPRMELLAAV-LGA-RLATAVKAN-- -H------S-EKV---TKV---IF---------HI------------------------- -------------------------------------WYLPLNVV-------LNVK-K-P GKV-RLVWDAAAA-V-QG---RSLNSELLKGPDLL--SSLPSVMCPFR---ERPI--AFG GDIAEMYHQVRIREC--DKSAQR-----F------LYRPN---A-SG---------P-PT IYVMDVATFGSTSSPCSAQYI-KNLN------------A----QEY-AKEF--P-DAVEA I-VNK--HYVDDY-LDSTF-T---VREAIERANQVA-FI-HSKA-------GFNIR-NWV SNST-EF-LQHF--DG-----QPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PM LRPFSYVGVDYFGPVV-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WIC---L -FTCLV--TRAIHMEVAHSLNSQSC-----VMAIRRF-ICRR-GAPLEIFSDNGTNFLAA SKELS-Q-K------VRY-IEL-E----------------------CA---DIFTDARTR ----WNFNPPAAPHMGGIWERLVRSAKEALKA-LH--D---G-GKL----TDEIL----- --LTV-----LTEAEDMINSRP--------LTY------------V-------------- ----------------------PQ-------------ES--------------------- ----------- >446/1-547 ---PTKRQVLQVLMRIFDPLGLIAGLLLYLKVLLQE-VWRS-G----------T------ -GWDE-P-IPY--ELKERWNEWLACLPHLE---T-ITIP--RCY--R------------- -KSLSLE--TSKL-QLHV-FVDAGKD-GFA-AVAYFR--FSS--KD------DVEI-A-- LIGG---------------------------KTRV-APL--K-Y---------------- --------------------------------LSVPRLELQAAV-LGT-RLAKSITNA-- -H------R-EKV---IQR---FF---------WC------------------------- -----------------------------------KTWYLPIFPV-------VNPN-K-P GKV-RLVWDAAAK-F-HG---VSLNSMLLSGPDLL--SSLTSVLQRFR---EYRV--AVA ADIREMFHQVLVKED--DQNSQR-----F------LWRWN---R-EQ---------TEPD EYVMQRMTFGAACSPTSAQFV-KNLN------------A----DKY-ATSH--P-RAVEC I-KRD--HYVDDM-LISTE-T---VMEAKTLAYEVT-KI-HGEG-------GFLLH-NWL SNSP-EV-FNYA--TG---STST---QKELNI-----------------------NEL-S AT--Q-----------------KI--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------PF ARPFTHTGIDYFGPFT-------------------------------------------- ----------------------------VV--NG-R-----K-SE-----KR-WGV---L -FTCLT--IRAVHIEVAHTLSTSSC-----ILALRNF-IARR-GVPNEIISDRGTNFVGA SRELQ-E-------ALKEIDVD-K----------------------IV---DGISLTSTK ----WTFNPPAAPHFGGAWERLVRSIKRTLTNIQF------T-KYP----TDAVF----- --NSW-----LIEVEFIINSRP--------LTD------------V-------------- ----------------------PV-------------DR--------------------- ----------- >448/1-553 ---PTRRNVFSFIAKLFDPLGIIAPIIAWAKIMMQR-LWIA-T----------K------ -EWDD-P-IPV--DLADQWELFKKQLYLVK---E-MRIP--RYV--M------------- --LL-D-QT--NV-QIHS-FADASEV-AYG-ACVYLR--VTNR-EG------TVKI-G-- LLAA---------------------------KSKV-APL-------K------------- ---K----------------------------LSLPRLELCAAV-LGA-KLWKTACIA-- -L-K----Q-Q-I---TES---YF---------WS------------------------- --------------------------------------YLPHHPV-------VKLS-SAS TKV-RPVFDGSAKTS-TG---FALNDCLLNGPVLQ--DTLFDLIVRFR---SYAI--ALI ADIEKMYLQVKVHEE--HTPLQR-----I------LWRSS---Q-QE---------EI-K HFELQRVTFGLTSSSFLATRV-LFQL------------A----ADE-GERF--P-LGKRA L-QES--FYVDDY-IGGAN-S---DAEAVQLVSELR-QL-LEKG-------GFHLR-KWN SNNK-MV-LRNLSPEEKDKCK--L-V-SIG---------------------------P-- -EDQV-----------------KT--LG-------------------------------- -----VYW---------------------------------------------------- ----------------------------------------------------------TP ARPFLTTGIDFCGPVY-------------------------------------------- ----------------------------LKPV--HRRA---TSQ------KA-YIA---V -FVCFC--TKAVHLELVEDMTTSAF-----LAAFRRF-ISRR-GYPSDVYTDNGLNFRGA QRELN-D-------LFRLLSDD-SF------------------QATTR---EETMKCGIT ----WHFIPPRAPNFGGLWEAAVKSTKKTLTKLFG--S-----QRL----SFADM----- --STV-----LTQIEAQLNSRP--------LTP------------L-------------- ----------------------SE--------DPE--E-------L-------------- ----------- >449/1-536 ---PTKRQVLRLVMSLFDPCGFIAHFTVHGKILMQH-IWRS-G----------T------ -DWDE-Q-IAD--DLREMWKDWTRLLKQLI---D-VQVP--RCF--F------------- -GEGESK-LPATI-QLHL-FVDASEL-AYA-CVAYLR--IVQ--AE------TVRC-I-- LVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAGV-IGC-RLLNTICTA-- -L------D-LPI---ESR---YI---------WT------------------------- ---------------S---------------TESNRVWYLPIGVV-------RNPR-K-P EKI-RLIWDAAAR-V-RG---LCFNDMLLKGPDML--TSLFDVLLRFR---QRSI--AIC GDIREMFHQVRIISS--DKQSQR-----F------LFREH---Q-SE---------Q-PQ IYVMDVATFGAKCSPCSSQAV-KNKN------------A----EEF-AAEY--P-RAAEA I-INA--HYVDDY-LDSVD-T---VEEAVQLVTDVK-HV-HAKG-------GFEIR-NFS SNSV-DV-LQQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PN IRAFSYTGIDYFGPLL-------------------------------------------- ----------------------------VK--VG-R-----S-LA-----KR-WVA---L -FTCLT--TRAVHLEVIHSLSTKAC-----IMAIRRF-VARR-GSPAAIYSDNGTCFKGA SNILA-N-Q------IQG-IHE-D----------------------CA---VTFTNARTT ----WHFNPPSAPHMGGCWERMVRSIKVAMAGIAE--Y---P-HHP----TDEVL----- --ETV-----VLEAESIVNSRP--------LTY------------I-------------- ----------------------PL-------------DDMEQEALTPNHF---------- ----------- >45/1-580 ---PTKREFLSLIMSTFDPLGFLSCLMITGKLLMRE-IWRR-N----------V------ -QWDE-P-LPD--EIARAFSKWFQDMNNVE---G-FRSS--RHY--F------------- -GPTPVR----AI-QLHV-FVDASQS-AFA-AVTYLR--VTYD-NN------DVRV-C-- FVCA---------------------------KTKC-APM--K-T---------------- --------------------------------MSIPRLELQAAV-LGT-RLMDTVKKE-- -H------S-IAI---SDA---IL---------WT------------------------- -----------------------------------KLWYLPHFGV-------ENPN-K-P GKI-RLVFDAAAK-V-GD---ISLNSALSKGPQHY--KSLPAVLFHFR---EGAV--GVC GDIREMFHQVLIRPQ--DRCAQR-----F------LWRNG---D-DR---------REPD VYEMRVMTFGAACSPSAAHYV-KTLN------------A----LQF-QDSD--P-RAVKA I-LEC--HYVDDY-VDSFD-S---EGEAITISTRIR-EI-HANA-------GFELC-QFT SSSP-TV-ADAL--GQHGTARSIGWGEAE------------------------------- ----E-----------------KI--LG-------------------------------- -----MCWQPATDDFKFNMKYHKVPRCVLNLERIPTKREFLSLIM--------------- ----------------------------------------------------------AN GWPFKFTGLDYFGPLL-------------------------------------------- ----------------------------VT--IG-R-----R-KE-----KR-WVA---L -FTCLT--TRAIHLELAHDLSTDSC-----IIVIRNF-LCRR-GPVLRLRSDNGKNFVGA NREAK-R--------LIDVFEPEK----------------------IQ---GELSSRGIE ----WIFNCPANPAEGGAWERMVQCVKRVLRHTVK--E-----VAP----KQHVL----- --ESF-----LIEAENVVNSRP--------LTH------------L-------------- ----------------------PV-------------SV--------------------- ----------- >450/1-566 ----TMRSILSMIAQLYDPLGLISPVIITAKVLMQS-LWRL-K----------L------ -SWDD-T-VPE--DIQRNWIRFRAELPELK---D-FRIP--RFA--F------------- --AH-Q-YR--QA-EIHC-FTDASEL-AYG-ACIYIR--SEAE-DG------SIHV-N-- LLAS---------------------------KSRV-APL-------K------------- ---A----------------------------LTIPRLELCGAL-LGA-RLHEKVMAA-- -M-E----I-K-F---VAH---RF---------WT------------------------- -----------------------------------TCCYLPHHPV-------FKET-SST TKM-RVVFDGSAPTS-TG---HSLNDALLVGPVIQ--DDLLSLIIRFR---KFQV--ALV ADLEKMYRQVLVHPE--DRPLQR-----I------WWRFD---D-NQ---------PI-Q AYELRTVTYGLAPSSFLATRT-LQQL------------A----EDE-GDAF--P-TAKDT L-KKQ--LYVDDL-IAGSN-S---VDGAIQLREELS-AL-AQRG-------GFTFR-KWC SNSL-AV-LSDVPAEQLATKS--S-L-RFD---------------------------D-- -KETI-----------------ST--LG-------------------------------- -----ICWEPEIDTFQFNI----------------------------------------- ----------------------------------------------------------TV NEVFSCTGLDYCGPLY-------------------------------------------- ----------------------------LRPT--HRKA---APN------KC-YIC---V -FVCMS--TKAVHLELVGDLSTNSF-----LMALDRF-VYRR-GKPKHIYSDNGTNFIGA KNELH-Q-------IYKMLFND-SA------------------DSKIA---KHLAKEEIQ ----WHLIPPRAPNFGGLWEAAVKVAKTHLIRQLG--S-----SRL----SSEEM----- --TTV-----LVKIEGCMNSRP--------LVP------------L-------------- ----------------------SE--------DPN--D-------L-------------- ----------- >451/1-547 ---PTKRIVLSCVMSFFDPLGLLAVFTIHGRIIVQD-LWRS-G----------C------ -DWDE-V-IDE--EAMEKWTRWTVCLKEVE---G-VRIP--RYY--F------------- -VNGVAL-DYGSL-QLHI-FVDASEN-AYG-GVGYFR--ILSG-GV-------PYC-A-- LVQA---------------------------RSKV-API--K-P---------------- --------------------------------HSIPRLELMAAV-LGA-RLKDTILES-- -H------N-FEV---SKL---YF---------WT------------------------- -------------------------------------WYLPLNVV-------LNPK-K-P GKV-RLVWDAAAA-V-QE---VSLNSMLLKGPDLL--VSLPSVICQFR---ERKI--GFG GDIREMFHQVRIRPE--DRQAQR-----F------LYGG--------------------E VYVMDCAIFGATCSPSQALYV-MHKN------------A----REX-EKDY--P-DATEA V-VKK--HYVDDY-FDSVD-T---VDEAVKRAEDVR-KV-HSHG-------GFQIR-NWV SNSE-EV-LTRL--GE-----RQVNQEIHFHR-----------------------D-KTT DY--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PF LRPFTYTGVDFFGPIS-------------------------------------------- ----------------------------VA--VG-R-----R-TE-----KR-WVA---L -FTCLT--TRAVHLEAARNLSTASC-----LMAIRRF-VCRR-GSPVEFFSDNGTNFVGA SKEI-----------IKE-INE-D----------------------CS---ENFTNARTR ----WNFNPPAAPHMGGVWERLVRSVKEALNE-LD--D---G-RSL----SDEVL----- --ETV-----LAEAENMINSRP--------LTF------------V----SKENTEPEAL T---------------------PN-------------HF--------------------- ----------- >452/1-522 ---PTKREMLRLVMSIYDPLGLVASFVIHGKILIQE-VWRS-K----------I------ -DWDS-C-ISE--EIATYWTDWIAVLKRMD---G-LRIP--RCY--F------------- -SGYDPA-SFKTL-ELHI-FVDASEQ-AFA-AVAYFR--IVD--QG------QIRV-A-- LVSS---------------------------KTKV-APL--R-G---------------- --------------------------------LSIPRLELMAAL-LGA-RLRRTVEEN-- -H------T-LKV---QKT---CF---------WS------------------------- -------------------------------------WFLPIGVV-------VNEK-K-P GKV-RVIWDAAAK-V-DG---VSLNSMLLKGPDLL--TPLLSVMFPYR---ERQV--AVS ADIKEMFLQISIRPE--DRSALQ-----F------PYRDS---P-EL---------P-MS TMVTDVAIFGAACSPAHSQFI-KNLN------------A----SEQ-EAEF--P-RGAAA V-KKR--HYVDDY-VNSHD-T---AEEAIEVAKEVI-EV-HKRA-------GFHIR-NWM SSDR-SV-VEQL--GE-----PN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PD VRPFTFVGVDLFGPYL-------------------------------------------- ----------------------------VK--VG-R-----S-VA-----KR-WVC---L -FTCLT--VRAIHLEVVASLSTDAC-----KKAIRRF-VARR-GSPQEIFSDNGTNFIGA SRELQ-D-E------FRR-MAT-E----------------------LG---STFTNAHTQ ----WRFNPPAAPHMGGCWERMVRAVKAALGC-VP--V---V-RKL----DDESF----- --ATV-----LAEAESMVNSRP--------LTF------------I-------------- ----------------------PL-------------ET--------------------- ----------- >453/1-554 ---NTKHQLLSDAARLFDPFGWFAPVIIRAKILFQH-CWLY-D----------L------ -NWHD-P-LPP--AVEEKWIEMKENLHQLE---R-IHIT--R-W--A------------- -PNYNNQ--I----ELHG-FSDASEE-AYA-AVVYLR--SVDF-DG------KIHV-T-- LLAA---------------------------KTKV-APV--R-Q---------------- --------------------------------VSLPRLELNAAE-LLA-KLMKQIAES-- -L------K-RFQ---IEQ---YA---------WT------------------------- ------------------------------QVEWTRSYYLPHHGV-------VKED-SST TKL-RVVFDASCATT-SG---ASLNDLLLDAPNIN--SDIFDIMMDFR---FYEV--VFT ADAVKMYRQILMHPA--DRDYLR-----V------VWRSS---P-DK---------PI-Q HFRLRTVTYGLKNSGFLAMAA-LKKA------------A----DDY-EGIY--P-EAAQR I-KKS--TYVDDL-TSGAR-T---TEEAIRLIKEIN-EI-VESA-------GFTLR-KWS SNST-AV-LESLPQTTTASQQIQF-PDERD------------------------------ ---TV-----------------KA--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------TA CRPFSHVGVDYAGPIL-------------------------------------------- ----------------------------VRCS--NTRG---ERCS-----KG-YIV---V -FVCLS--SKAVHLEVAGDLSADTF-----LGAFKRM-IARR-GYCNELWSDNGTNLVGA NRQLT-E-------IYEATQSH-SK--------------------KTE---PFFSNLGIR ----WRFIPPSSPHQGGIWEAAVKSAKELLRPVVG--N-----EKL----TFEKL----- --STV-----LCQIEACLNSRP--------LYP------------I-------------- ----------------------ST------------------------------------ ----------- >454/1-589 ---YTKRKVLSTIAQLYDPLGLITPITIRAKILMQQ-LWLL-N----------L------ -DWDS-T-ISP--SLQNSWAEFLEQIPTLT---N-FRID--RFA--F------------- --QP-H-YE--QL-EIHC-FSDASES-AYG-ACVYVR--TEDK-HG------SARV-N-- LLTS---------------------------KSRV-APL-------K------------- ---P----------------------------LTIPRLELSAAL-LGA-RLFKKVQHA-- -L-N----I-P-L---DTC---YF---------WS------------------------- ------------------------------REDCSGAFYLPHHPV-------LKDS-SST TKV-RVVFDGSAKTS-TG---KSLNDALLVGPVVQ--EELLTLIIRFR---KYEI--ALI ADIEKMYRQVTMNPT--DRHLQR-----I------LWRFD---N-SQ---------PI-R TYELGTVTYGLAPSAFLATRT-LIQL------------A----NDE-GDKY--L-KARSV I-KEN--VYVDDL-LAGAN-N---IPETIELRNQLN-AL-LQKG-------GFLLR-KWC SNAP-AV-LADLPPELVATHS--S-V-NFD---------------------------P-- -DESI-----------------KT--LG-------------------------------- -----ICWEPMSDKFRINININIIKSPYTKRKVLSTIA---------------------- ----------------------------------------------------------TI NEVFSCVGVDYCGPLY-------------------------------------------- ----------------------------LRPS--HRKA---ASP------KA-YVC---V -FVCMS--TKAVHLELAGDLSTTTF-----LMALDRF-VSRR-GKPKNIYSDNGTNFIGA KNALH-E-------IYQFLHKD---------------------NNKIT---NHLSNENIX ----WHLIPPRAPNFGGLWEAAVKVAKTHLVRQLG--T-----AQL----SYESM----- --CTL-----LIKIESCMNSRP--------LLP------------L-------------- ----------------------SQ--------DPN--D-------L-------------- ----------- >455/1-557 ----TKRIALSQIARLFDPLGLLGPVVITAKIFMQT-LWTL-K----------A-NNGKV WSWDE-E-LPL--KLKEQWRSYMYELPILN---N-LRIG--RYI--L------------- --SS-R-PA--FI-QYHF-FSDASQH-AYG-ACCYVR--SADT-SG------SFTV-A-- LLTA---------------------------KSRV-APL-------K------------- ---Q----------------------------QSIPRLELCGAL-LAA-ELYQKVSQS-- -L-E----L-P-----GAT---FF---------WV------------------------- -----------------------------------PCYHMPHHAV-------IRED-STT TKL-RVVFDASCKTA-DG---PSLNDALLVGPTVQ--QDIRSIIMRSR---IRRV--MII ADAKQMYRQILVDER--DTPLQR-----I------VWRNA---P-EQ---------PL-I TYELKTVTYGTASAPFLATRV-LVQL------------A----NDE-QQQF--P-VAAEV V-RKD--FYVDDL-FSGAD-S---VEEATELRGQLE-TL-LLKG-------GFQLR-KWA SNEE-AV-LKDVASDNRALQA--S-V-DLD---------------------------R-- -NQTI-----------------KS--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA TRPFSTTGVDYWGPIT-------------------------------------------- ----------------------------LRPT--HRRG---ASQ------KA-YVA---V -FVCFS--TRAVHLELVIDLSTAKF-----LQALRRF-VARR-GICQQIYSDNGRNFVGA ANELR-K-------L---VRSK-EH------------------HQAIA---QECSNIGIC ----WKFNPPKASHFGGLWEAAIRSAQKHFIRVLG--T-----HVL----AQDDM----- --ETL-----LVQIECCLNSRP--------IVP------------L-------------- ----------------------SE--------DPS--D-------L-------------- ----------- >457/1-541 ---PTKRELLKFMMGIFDPLSMLSPITIHLKIMFQE-LWRL-Q----------T------ -GWDD-K-LPD--GIIPKWKEWLDETAKLR---E-IRIP--RYY--F------------- -PGLSS---FGCI-EIHA-FCDASDK-AFA-CVIY----IVHRYDN------KSNV-A-- QVFA---------------------------KSRV-APL--K-S---------------- --------------------------------QTVPRLELQGCV-LAS-QMSKTVQDE-- -L------H-VEI---TSV---YL---------WT------------------------- -----------------------------------NTWYLPHFSV-------HSAN-K-- --F-RLVMDAKAK-S-HG---FSLNDLLLKGPDFV--PPLIAVLMRGR---KKKI--AFT ADIKEMFHQVLIRPQ--DQDSQR-----F------FWRGM---NRSD----------PPE VYVMVAMIFGAVSSPSIAQFI-KNFN------------A----REL-DERL--P-GVERA I-VDQ--HYVDDY-FDCED-T---EQEAIDLIQKVI-TA-HECG-------GFKLV-KFT SNSK-TV-VQTI--------------DPSLRA-----------------------DLGES RT--V-----------------RI--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------PY TYPFNYTGIDYFGPLM-------------------------------------------- ----------------------------VK--VG-R-----H-LE-----KR-WVV---L -FTCMT--SRAIHLEVVPALDTNCC-----IMAIRCF-MAFR-GVPKKILTDNGTNFTGA NKELK-K-------LVQELDQP-S----------------------IE---ETLSNRGIE ----WQFIPPGAPHFGGCWERLIRTVKTALNVMLK--E-----RNP----TDLIL----- --RTT-----LCEVMNVVNNRP--------LTH------------I-------------- -------------------SDDPQ-------------DP--------------------- ----------- >458/1-577 ----TKRRVLSIIATLFDPLGLIGPVITTAKVFMQL-LWCL-E----------D-DKGKK LDWDH-P-LPP--VVDTEWRSFHAQLPQLN---K-LAIE--RCV--V------------- --KP-K-AV--IV-ELHL-FSDASVQ-AYG-ACAYMR--SVDS-SG------AVGV-V-- LLTA---------------------------KSKV-APL-------K------------- ---C----------------------------QSIPRLELCGAL-MAA-QLSEKVLEA-- -I-K----M-D-----VEV---FF---------WT------------------------- ------------------------------EGHNKTRCYLPHHPV-------VKEE-STT TKV-RVVFDASCKTS-TG---TSLNDTLLAGPVIQ--DNLRSIILRSR---TRQI--MVI ADVEKMFRQIGISEE--DASLQS-----I------LWRTD---P-SE---------EI-S TYELTTVTYGTKPAPFLATRT-LKQL------------A----LDE-QADY--P-IAATT A-TED--VYMDDV-LSGAD-N---PEAALELRSQLD-EM-TRKG-------GFRLR-KWA SNCP-LV-LQGIPEEDLAVVRIEG-V-QLD---------------------------P-- -DPAV-----------------RS--LG-------------------------------- -----LVWHPTADVLQFRF----------------------------------------- ----------------------------------------------------------TV SRPFSSTGVDYFGPVY-------------------------------------------- ----------------------------VRLA--PRRT---A-V------KA-YVA---V -FVCMC--TKAVHLELVTDLTTDRF-----LQALRRF-VGRR-GRCSEXYSDNGTNFVGA RNQLK-Q-------LFELLKDK-EH------------------QEKIA---KECTKEGIQ ----WRFNPPSAPHFGGLWEAAVRSAKYHLLRVLG--D-----QVL----SFEDM----- --STL-----LVQVEACLNSRP--------LTA------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >46/1-556 ---YTKRAVLSQIARLFDPAGWLAPFIVRSKIFMQE-IWLQ-D----------L------ -GWDD-E-LPS--EMRQRWQSFLRSYSALD---Q-IHIP--RWV--G------------- -SRPAV-----KV-EHHG-FCDASEK-AYG-AAIYVR--IEVD-RL------V-EV-Q-- LLTA---------------------------KTRV-APV-------K------------- ---T----------------------------VSLPRLELCGAV-LLS-EMAAAILPN-- -M------P-TAS---TSC---YC---------WT------------------------- ------------------------------PTHGSSTYYLPHHAV-------FKPE-STT TKV-RVVFNASSPST-NG---VSLNDLLHAGPVLQ--SDLTLQILKWR---YFRY--VFN ADITKMYRQIWVDPK--HTPFQR-----I------LFR-N---K-EG---------LI-R DYELKTVTFGVNCAPFLAIRV-LQQL------------A----SDV-QSRF--P-KASRI I-RSF--MYVDDV-LAGAD-S---TDEARLTIRELQ-AA-LSSA-------GFPLR-KWT SNHK-AI-LAGIPSAHLLHTD----FLEME------------------------------ EESTA-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------SF SRPFTHTGIDYAGPFE-------------------------------------------- ----------------------------IRNY--TGRA---CLIT-----KG-YVC---V -FVCFS--TKAIHLEPTSDLTTEKF-----LAAFARF-VARR-GCPQRIHSDNGKTFVGA ATLLSSD-------FLDAF------------------------KDSVT---DAYSHQRVS ----WRFIPPGAPHMGGLWEAGVKSFKTLFYKATS--T-----RRY----TFEEL----- --STL-----LAKIEACLNSRP--------LSP------------M-------------- ----------------------SD--------DPT--E-------L-------------- ----------- >460/1-575 ---FTRRGVLSTIASVFDPLGFMAPFILVGKKILQQ-LCYN-K----------A------ -SWDD-S-LPE--DLQSXWTRWLLDLPNLA---D-VKIP--RCY--V------------- -PQISNR--AIRF-ELHH-FSDASIS-GYG-ECSYLR--TVSA-SG------EVHC-S-- FVMG---------------------------KSRV-APT--K-I---------------- --------------------------------TTIPRLELSAAV-VAV-RVSDMLKKE-- -L------D-IKD---LQE---CF---------WI------------------------- -------------------------------------WYIPHHGV-------YHPK-K-P GKI-RVVFDCSAR-F-QG---TSLNDHLLTGPELT--NTLVGVLCRFR---KNPV--AIM CDIERMFHQFHVKAE--DRDYLR-----F------LWWDN---GNLE---------AQPS VYKMKVHLFGAASSPGCANYG-LKHL------------A----AEG-KGMF--XEDVIRF I-QRN--FYVDDG-LVSVP-T---EAEAIALVTEAK-KL-CSTG-------KLRLH-KFI SNSK-XV-IASI-------PQEDLAKGVKDLD-----------------------LDLGE -MYVE-----------------RA--LG-------------------------------- -----VQWSIASDEFQFRVIVK-------------------------------------- ----------------------------------------------------------QP TPPFLLCGMDCFGPFY-------------------------------------------- ----------------------------VT--DG-R-----R-QL-----KR-YGL---L -LTCMC--SRAIHIEMLDALSTDAF-----INALRSF-IAIR-GTVRQIRCDQGTNFVGA SREFM-S-------TLKTMDQX-Q----------------------IK---KL----GCE ----LIMNIPSASHMGGVWERQIRTVRNVLTSVLD--Q---CPGAL----DSTSL----- --RTL-----LYEVMAIVNSRP--------LTV------------E-------------- ----------------------HL--------N----DPLGPEPLTPNHI---------- ----------- >461/1-556 ----TMRTAYQILATQYDPLGFIVPFTTRAKVLIQQ-LWSK-K----------R------ -DWDD-PNLPQ--DLSRAWETWENELKHLS---D-ITIP--RCYSSI------------- -PHDAQQ----QY-ELHV-FCDASER-AYG-AVAYL---VE-Y-AD------VIHS-T-- FVMA---------------------------RSRI-APK--R-Q---------------- --------------------------------QSIPRLELCAAL-AGA-QLAKLLKEE-- -I------T-LKI---QQI---VL---------WT------------------------- -----------------------------------EAWYIPHHLV-------CHN----- DKP-RLVFNCSFR-S-QG---QSLNDQLLPGPALG--PSLLGVLLRFR---QYNV--AVS ADIRGMFHQVRLLPE--DRPLLR-----F------IW-RD---LQYE---------NCPD VYEWQVLPFGTTSSPCCAIFA-VQQH------------A----RNN-QES---YPSALQT I-QQS--FYVDNY-LASFP-T---TSEARVSVDQLR-SL-LATG-------GFDLR-PWA SNQP-AV-ISHL-------PTEARSSAAEQWL-----------------------AQNRT -DPME-----------------PT--LG-------------------------------- -----LRWNCAADTLGYHY----------------------------------------- ----------------------------------------------------------IL CPPFYSTGVDCFGPYQ-------------------------------------------- ----------------------------VK--IG-R-----R-VE-----KR-WGV---I -FKCLT--TRAVHIELLNSMDVDAF-----LLALRRF-IARR-GRPKELRSDCGTNFRGA DRELR-E-------AFAAMESP------------------------LK---ERLADHQIT ----FKFNPPHAPHFGGTWEREVRSIKTALRAAVG--G---Q--SV----SEDVL----- --TTV-----LVEVEGILNSKP--------LGY------------A-------------- ----------------------ST-------------DI--------------------- ----------- >462/1-554 -----RRGILSAVASVYDPLGLIAPVLFNGKRILQE-MCKN-G----------S------ -GWDD-P-LMD--GLSLRWVKWKQDLQSLQ---N-LSIP--RTY--V------------- -PLNFGK--PISI-ELHH-FSDASND-GYG-QCSYVR--VKNE-EG------NVHC-A-- LVMA---------------------------KSRV-APL--K-V---------------- --------------------------------VTVPRLELAAAV-VSV-EVSNVLKRE-- -L------D-YPV---ANE---TF---------WT------------------------- ---------------S---------------GKEGETWYLPHHGV-------FHPK-K-A DKL-RVVFDCSAR-H-EG---SSLNDHLLQGPDLI--NSLHGILIRFR---QHPI--ALT CDVEKMYHQFHVDEP--DRDFLR-----F------LWWKN---GDIT---------QPVH EFRMKVHLFGAASSSGCANYG-LKHL------------A----TEN-GELY--PLGS-QF L-LKN--FYVDDG-VISVE-N---VHEAIKVADEAR-RL-CALG-------GLRLH-KFL SNNE-LV-LKGI-------PQSERMCGVRGLD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DP SPPFLYTGMDCFGPFS-------------------------------------------- ----------------------------VK--SR-R-----N-VQ-----KR-YGL---L -LTCLC--SRAVHIELLNDLTTDSF-----INALRCF-IAIR-GTVRQLRSDQGTNFVGA RNELK-G-------ALCEMDPE-R----------------------IT---TFLLENQCE ----FIMNTPHASHAGGVWERQIRTIRSVLNATFA--L---YPGKL----DDSCL----- --RAF-----LYEAMAIVNSRP--------LTV------------D-------------- ----------------------CL--------N----DPQSLRPITPNNL---------- ----------- >463/1-527 ----TRRHLLSQVAGLYDPVGLVTPAKQKGAILVRK-AFQETG----------KGSL-TR ETWDM-P-LSE--NLREEAIRLFEEYVQLN---Q-VKFH--RSL--T------------- -PPGWKGKPWGIT------FSDGSDK-TYG-AVLYLR--WNTD-QG-------IDV-R-- LVES---------------------------KAKL-TPLDQK------------------ --------------------------------GDAVKAEICGAV-FAA-RLRKYFEKH-- --------GRMEV---ERW---FH---------LV------------------------- ----------------------------------------------------PNPH-STT TPV-RLVWNSSQK-F-KG---LSMNDLLLKGPDVL--NPIRAVLLRFR---KGVF--AAL GDIKKMYNSVWLEER--EVHLHR-----F------LWRDT---Q-DE---------EISE -YAITRVNIGDRPAGCIAQLA-MRET------------A----RLA-KFAH--LKEECRV L-EED--SYVDDI-LTSHN-S---QERLKEITNGLE-EI-LAAG-------GFALK-PWV RSEQ-SG-RNE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP AAPFEYTTLDLFGPYI-------------------------------------------- ----------------------------VKDEVRKRVHL-----------KV-WGI---V -YCCMA--SRAIHTDIVSDQSAEGF-----MLAYQRF-TALR-GHPRKLWSDPGSNFIGV KPALT-E-------LYKFLDKL--------------------ETSELE---EKAAKHGTE --WVWKIHPASSPHRNGAAEAAVRIVKRALHNLGG--D-----GVF----TWSEF----- --QTF-----LYMAANLANERP--------IDA------------R-------------- ----------------------TQSREDC------------------------------- ----------- >464/1-573 ---STRXGILSVIASLYDPVGFVAPFILTGKCILQE-LCRR-G----------I------ -DWDD-P-LPE--DLSPRWESWKSDLQRLK---E-VSIP--RCY--Q------------- -PQGFCK--TVTR-ELHH-FSDASNI-GYG-SCSYLR--SKNE-DG------EVHC-S-- LVMA---------------------------KARV-APT--K-L---------------- --------------------------------TSIPRLELSAAV-VAA-RSSVMLRNE-- -L------E-MPI---HAE---FF---------WT------------------------- -------------------------------------WYIPHHGV-------FHPK-K-P EKL-RVVFDCSAK-F-RG---VSLNDTLLTGPDLI--NSLLGVLCRFR---KEAV--AII CDIEKMFHQFYVSPE--LRNYLR-----F------LWWED---GNLE---------AEPQ EYQMAVHLFGAASSPGCANFG-LKYL------------A----RQH-KEEY--PSAS-AF V-EKN--FYVDDG-LISVP-S---VEEAKELIAEAQ-EL-CKKG-------GLRLH-KFN SNER-SV-LDSV-------DPTERAVTSEPLN-----------------------LDLNA -APAE-----------------XA--LG-------------------------------- -----VQWSLEHDTFSF------------------------------------------- ----------------------------------------------------------EV SAPFTYCGIDCFGPFI-------------------------------------------- ----------------------------TK--KA-R-----K-EQ-----KR-YGL---I -FTCLA--SRSVHIEMLEDLSTDAF-----INALRCF-ISLR-GAVRQIHCDQGTNFVGA RNEFQ-E-------SLKQCDTK-T----------------------ID---SFLAEKQCE ----FIFNAPSASHAGGVWERQIRTVRNVLNATLC--Q---YLGRL----DDSSL----- --RTL-----FYEAMAIVNSRP--------LTV------------N-------------- ----------------------GV--------N----DPTSLEPLTPNHL---------- ----------- >465/1-527 ---PTKRQILKCIMSLFDPLGLLAPYLVFGKILMQN-VWRQ-G----------I------ -GWDE-V-VDD--RLFEQWQHWTKMIDHIN---Y-IRIP--RSY--F------------- -RKAGAK-GFQNI-QLHT-FVDAGGD-ACA-CVSYFR--IVNE-EG------TVEI-A-- LVSA---------------------------KTKV-VPL--K-P---------------- --------------------------------ITIPRLELQACV-LGT-RLAKYIVEG-- -H------S-III---KKR---IF---------WS------------------------- ---------------D---------------LDPRRTWYLPLGAV-------TNPN-K-P GKV-RLIWDASAK-V-DG---ICLNSLLLKGPDLV--TPLCFVMFRFR---QHSV--AIS ADLKEMFHQVRIREE--DRPAQS-----F------LFRSD---P-EN---------E-PQ IFHMNVATFGATCSPAIAQHV-KNAN------------A----KEF-EEKH--P-RAVEG I-VFN--HYVDDY-LDSFA-T---EEEAKQVTTEVR-EI-HRCG-------GFELR-NWC SNKD-GV-LQHL--GQ-----MV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFSFVGLDYFGPFL-------------------------------------------- ----------------------------VK--VG-R-----S-QV-----KR-WIA---L -FTCMT--IRAVHLEVAQSMSTESC-----VACVRRF-VCRR-GFPVEIHSDNGTNFQGA ERLLR-E-Q----------INT-E----------------------LA---STFTSTTTA ----WHFIPPATPHMGGAWERLVRSVKTALTAA-Y--N---N-EKL----DDEAL----- --YTM-----IIEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >466/1-558 ---PTKRDILRVMMSVYDPLGLLSHYMIYLKLLFQE-IWRE-G----------T------ -LWDD-E-IAE--TQLQKWKCWLHLLPEAE---S-ARIP--RCY--D------------- -LSPSLG-TNRLV-ELHT-FVDASEL-GYA-AVCYFR--FIE--EN------RITC-S-- LVAS---------------------------KIKV-APL--K-F---------------- --------------------------------VSIPRLELQAAV-IGT-RLAKSVEXG-- -H------S-ISI---ARR---FF---------WT------------------------- -----------------------------------RVWYLPIFPV-------FNPN-K-P NKI-RVVWDAAAT-V-GE---TSLNSVLMKGPDLL--NDLPSVLYRFR---ERPV--AVS GDIAEMFLRVKMNET--DQHCQR-----I------FWCDE---D-GS---------TA-- EYVVTVMTFGAKCSPSCAQFI-INHN------------A----SKF-KSQF--S-EAVEV I-QKG--HYVDDM-LASVD-S---EEEAIKLATDVH-YT-HEQG-------GFTMR-NSV SNSS-AV-VKAL--GE---TGSA---EKSLNV-----------------------DKD-A VL--E-----------------KI--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY VRPFSYVGIDYFGPYQ-------------------------------------------- ----------------------------VI--VG-R-----H-PE-----KR-WGV---L -ITCLT--TRAIHIEIAHSLSTSSC-----IMALQNC-FARR-GTPLQIISDRGTNLVGA SKKLK-E-------ALRNLDTS-K----------------------IA---AEFTTASTA ----WSFNPPSSPHMGGAWERLIQTVKRILIQIKP--S---K-RLP----TDECL----- --RNC-----LIEIENIVNSRP--------LTH------------I-------------- ----------------------PL-------------DDESSSALTPNHF---------- ----------- >467/1-547 ---PTKREVLKVIMSLFDPLGFVSFFLVHGKILMQD-VWAS-G----------I------ -GWDE-K-IND--QLFLRWQQWTAYFSQLD---T-MRIP--RCY--F------------- -SSPFPK-NLDRL-EVHI-LVDASDT-AYA-CVAYYR--LET--EN------GIQM-A-- LICA---------------------------KTKV-APL--K-V---------------- --------------------------------LSIPRLELKAAI-LGV-RMLEAIQGF-- -H------T-YAI---HRH---FL---------WS------------------------- -------------------------------------WFLPLGVV-------INPK-K-P GKI-RLIWDAAAK-T-GE---VSFNSYLLKGPDLL--TPLPRVLSGFR---LFPI--AVS GDIREMFLQIKLQAK--DRNAQM-----F------VFRHN---P-EE---------P-IQ VYAIDVTMFGSTCSPSSAQFV-KNLN------------A----EQY-ALHY--P-RAAVA I-KEH--HYVDDY-LDSFR-T---IEEAVQVVNDVK-FV-HSKG-------GFEIR-NFL SNEG-EV-LKRT--GEI----EPDS-SKEFAL-----------------------V-RGE TT--E-----------------SV--LG-------------------------------- -----MKW---------------------------------------------------- ----------------------------------------------------------PF IRPFTSVGVDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-SV-----KR-WVA---L -FTCLT--VRAVHLEVVHSLSTESC-----IMAVRRF-VARR-GCPAEFYSDNGTCFQGA SKELQ-REE------TIK-RNN-A----------------------LA---NTFTTSKTR ----WCFIPPAAPHMGGAWERLVRSVKVAIGSLAD--V---S-RKP----NDEVL----- --ETV-----LLEAEALINSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >468/1-572 ----TKREILSQISSLFDPLGLIGPAISKAKILLQG-LWKL-Q----------L------ -DWDI-Q-VPP--AIIIEWQDFQQKLTGLI---D-LRIP--RHV--L------------- --SPGY-AR--L--EVHG-FSDASEV-AYG-ACLYLR--SITS-AG------SCSV-R-- LLMS---------------------------KSKV-API--D-T---------------- --------------------------------KSIPRLELCAAH-LLA-KLLVHAMDS-- -I-D----I---S---ATV---YL---------WT------------------------- ------------------------------ERNKKPRYYLPHHAV-------IKME-STT TKL-RTVFDASCQSK-SG---LSLNDVLLVGPTIQ--DTLVTIVIRFR---IFEF--VAS ADIEKMYRQVLVADQ--DQPLTR-----I------VWRDH---P-DL---------PM-K IYQLLTVTYGTSCAPFLAIRI-LKKL------------A----DDE-EDHF--P-LAAPV L-RRD--FYVDNL-LTGAN-D---ASSLADTCKQLI-AM-LASA-------GLPLR-QWS SNNQ-TV-IDSIPPELRETET--L-L-DL----------------------------D-- HEASV-----------------TT--LG-------------------------------- -----LRWEPATDFLSFKQ----------------------------------------- ----------------------------------------------------------TQ AYPFENVGIDLAGPLY-------------------------------------------- ----------------------------VRPPIRSRSS---PFT------KA-YIV---V -YVCLV--TKAAHLDLVSDLSTEAF-----IASLRRF-TSRR-GKPARIFCDNATNFVGA RRELE-E-------LRKLFLTQ-QH------------------KDSVS---QDCADDGIE ----FNFILPRSPSFGGIWEACVKSVKTLLRKILG--N-----AHL----TELEL----- --QTA-----LIQVEAMLNSRP--------ITP------------L-------------- ----------------------PD--------DPS--E-------A-------------- ----------- >469/1-560 ----TKRIVASEMAQLFDPLGLVGSVVMSAKMFIQK-LWAI-H----------I------ -PWDE-E-LPD--NLKDWWLRFRAEIPELS---K-LKVP--RRV--L------------- --AN----TNNDY-ALHC-FCDASDR-GYG-ACVYVV--SSNG-TG------SNAS-L-- LLIA---------------------------KSRV-APL-------R------------- ---G----------------------------LTTPKLELCAAL-LGS-QLLEQVRKN-- -T-N----F-S-----KIV---TF---------WS------------------------- -----------------------------------PQFVLPHHAI-------FRPD-SAT TKT-RVVFDATCRGS-SQ---LSLNDLLLVGPIVQ--PPLLAIVLNWR---IPRF--VFK ADIEKMFRQIMVHPL--DRRFLQ-----V------LWRTD---A-FQ---------PL-Q RYQLTTVTYGTSCAPYLATRV-LNQL------------A----EDE-GHRF--P-LGAKI I-LKG--FYMDDA-LSGDD-D---LETAIEASKQLA-EL-LKLA-------GFHLR-KWS TNDP-KV-LKHVSDDLKEFSP------ETE----------------------------LD STGTV-----------------KT--LG-------------------------------- -----LLWSHGTDEFGFKI----------------------------------------- ----------------------------------------------------------TP ARVFLNSGMDYCGPFS-------------------------------------------- ----------------------------VRPL--VGRG---ANV------KI-YVA---V -FVCMV--VKAVHLEIVNDLSAVAC-----INAVKRF-IARR-GRVVNLYCDNSTAFVGA DRQLK-Q-------LRRQFLQQ-YS------------------TEQWN---GYCLENGIN ----FRFIPPQSPHHGGLWEAGVKSFKHHLRRVLG--R-----RSF----TLEEL----- --STA-----VAQIEGILNSRP--------LSP------------M-------------- ----------------------SS------------------------------------ ----------- >47/1-554 ----TKRSILSIASSLFDPLGLVTPIIIVAKIILQE-LWLL-K----------L------ -HWDE-S-VPQ--GIHTAWMSLLASLSSLE---S-VAIP--RYC--L------------- --QSAI-H---TF-QIHG-FCDASIR-AYG-CCIYAR--TIGS-DG------LTKV-Q-- LITS---------------------------KSRV-APT--K-K---------------- --------------------------------LSLPKLELCGAH-LLA-QLYKKIIRI-- -F-A----D---R---KPTS--FL---------WC------------------------- -----------------------------------PHYYIPHHCV-------LKPN-STS TKL-RVVFDASCKTT-SQ---KSLNDILMVGPTIQ--PDLYTLLLRFR---IHRY--AIT ADVVKMFRQVNMFAE--DRRFQY-----I------LWRAS---P-SQ---------PL-S TFELNTVTYGTAAAPYLAIRS-LSYL------------A----DKF-MDKL--E-IGAKA I-KSS--FYVDDF-LGGAD-T---VEELHQIKREVT-AI-LQDG-------QLELA-KWH SNHC-KF--VDDATVKHLQLD--------------------------------------- DEMLT-----------------ST--LG-------------------------------- -----LKWDQVRD----------------------------------------------- ----------------------------------------------------------TP SRPFSRCGIDFCGPIN-------------------------------------------- ----------------------------VYLR--IRGK---PPT------KA-YLA---V -FVCFA--TKAIHVEVVSDLTTDSF-----IASLKRF-IARR-GLPSDIFCDNATNFAGA NNKLE-S-------LKQFLFKD-ET------------------TKTIH---YFCRSEFIN ----FHFIPPRAPHFGGIWEAAVKSVKGLLNRTLR--D-----TRL----TFEEL----- --ATA-----AADVEAILNSRP--------LTP------------L-------------- ----------------------SS--------DPN--D-------L-------------- ----------- >470/1-526 ---PTKRQVLSTLMTIYDPLGLIGNYLMFLKIFLQE-IWRS-G----------V------ -AWDE-P-IAS--KQLEKWQLWLKVLPRIE---S-VRIP--RCY--R------------- -KETSTS-KMNDI-QLHV-FVDASEN-GYA-AVVYLR--FEE--NG------IIEC-A-- LVGS---------------------------KTRV-APL--R-F---------------- --------------------------------VSIPRLELQAAV-LGA-RLASSISDT-- -L------K-LKP---ACK---FF---------WS------------------------- -----------------------------------RSWYLXIFPV-------QNPN-K-P GKL-RIVWDAAAK-V-NG---LSLNSVLLKGPDLL--KSIVGVLYKFR---EFKV--AVA ADIVEMFHQVQMTPS--DQHSLK-----F------LWRGC---D-KS---------QDPE VYTMVVMIFGASCSPTCAQFI-KNLN------------A----QRF-ANQF--P-RAAEA I-VDE--HYVDDM-LTSVE-S---EAEAQDLAKQVE-YV-HGQA-------GFKIH-NWL SNSK-GV-LEVM--GA---EN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFSYXGIDYFGPLL-------------------------------------------- ----------------------------VM--VG-R-----R-VE-----KR-WGV---L -ITCMT--VRAVHIEVAHSLSTESC-----ILAIRNF-VARR-GMPLEIISDRGTNFVGA NHELK-D-------ALQKMNQD-K----------------------LI---ESFVSANTK ----WSFNPPATPHFGGCWERLIQSVKKSLNYVKP------S-RTP----TDELL----- --RNM-----LTEIELVVNSRP--------LTE------------I-------------- ----------------------PV---------------EH------------------- ----------- >472/1-549 ----TRRGLLSVVSSVYDPLGYASPFALRGKLILQE-LTRK-K----------L------ -NWDE-P-IPD--SDAKKWKAWIEELPQME---G-VEVS--RCV--K------------- -PHDFGR--ITDY-EIHN-FSDASEV-AYG-AVSYLV--MRNE-EG------EVHS-S-- IIMA---------------------------KSRL-APV--K-T---------------- --------------------------------VTIPRLELMAAT-LAV-NMDVVIRGE-- -L------D-LPV---KKS---YF---------WT------------------------- ---------------Q---------------PPNGTCWYLPHHPV-------INPK-K-P DKL-RIVFDCAAK-C-LG---VGLNDVVMQGPDLT--NKLTGVLLRFR---RAPI--AIM ADVEAMFHQVTVHPD--ERDVLR-----F------LWWPD---GRVD---------EDPK TYRMCVHLFGGTWSPSCCSFA-MRQT------------A----KDY-GDQC--NTQAPRV V-EMN--FYVDDC-LVSVE-E---EDEAIRLASELR-TL-LQKG-------GFRLA-KWM SSNT-RV-LQTI-------PVQDRAKQVVGLD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AD EPAFTHVGMDYFGPYE-------------------------------------------- ----------------------------IK--CG-R-----S-VR-----KR-YGV---I -FTCMT--TRAIHIEVANSLDTSSC-----IDAIRRM-MSRR-GPIKRLVSDNGTNLVGA KAELR-K-------ALSDWNVD-E----------------------IS---NFTANHSID ----WSFNPPGASHHGGVWERQIRTIRKVLHALLN--E---Q--YLRTCQSEEQL----- --HTL-----MCEVEAIINSRP--------LTR------------V-------------- ----------------------SD-------------D--------PGDL---------- ----------- >474/1-530 ---PTKRKVLSEIGQLFDPLGFLGPVIVFAKLIMQD-IWRL-G----------L------ -AWDE-E-LPD--DLQEKWHQFRRQLPALN---Q-VQKP--RCV--I------------- --QS-E-AV--TL-ELHG-FSDASKR-AYG-AVVYMR--SITA-DG------KIYV-N-- LVAS---------------------------KSRV-APL-------K------------- ---P----------------------------TTIPRLELCGAK-LLA-ELVKKVITA-- -M-K----I-R-L---DAV---RL---------WC------------------------- ------------------------------GG-----YYIPHHAV-------YKAS-SST TKT-RVVFDASAKTT-TD---LSLNDTVLVGPTVQ--NDIVSIIIRFC---IHSV--VLT ADISKMYRQVRLHKD--DCKYQR-----I------LWWND---D-GQ----------L-K TYELQTVTYGVASSPYHATRV-LVQL------------A----IDE-GEDF--A-LAKEI I-TED--SYIDDF-LTGGS-S---SEEVIQVYSELS-EL-LRRG-------GFEVH-KFC SNSN-DV-LGAIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------NP SPPFSKVGIDYAGPFM-------------------------------------------- ----------------------------LK--LGGRST---KLY------KG-YVV---V -FVCLI--VKAIHFELVSSLSTDDF-----IAALQRF-SSRR-GVPSDIHSDNATTFVGA NHELA-A-------LKQLFEDQ-QH------------------QLKVK---EFCSAKGIR ----WHFIPPRSPHFGGIWEAGVKSMKYHLKRVVG--E-----TRL----TFEEM----- --STF-----LAQTEAILNSRP--------LCP------------M-------------- ----------------------SD--------DPS--D-------Y-------------- ----------- >476/1-527 ---PTKREVLRILMSVFDPLGLLANVLMFLKVLLQE-IWRS-K----------I------ -GWDE-P-ITD--SQLERWRTWLSVLHKVE---S-VSVP--RCY--R------------- -TITTSSVDTNEI-QLHV-FVDASEN-GYA-AVAYFR--FEE--RX------TIEC-A-- FVTA---------------------------KTRV-APL--K-Y---------------- --------------------------------VSIPRLELQAAV-IGA-RLAKDIAET-- -H------R-IPI---RKR---FF---------WT------------------------- -----------------------------------RSWYLPIFPV-------VNPN-K-P GKL-RIVWDAAAK-V-GK---LSLNSFLLKGPDLV--TPLQHVLQRFR---EFRT--AVT GDIREMFHQVRINPE--DQHCQR-----F------LWNDG---V-PG---------KVPS TYAMXVMTFGASCSPSSAQYV-KNLN------------A----ERF-RSQF--P-DAVEA I-CXG--TYVDDM-LCSVE-S---EAEAVKLAQDVR-FI-HAEG-------GFEIR-GWL SNSE-KV-VEAM--GE---XK--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY SRPFSHAGIDFFGPMQ-------------------------------------------- ----------------------------VV--VG-R-----R-IE-----KR-WGV---L -ITCLV--VRAIHIEIAHSLNTSSC-----IMALRNF-MARR-GTPVELFSDRGTNFVGA NRELN-E-------ALQSLDRN-R----------------------IM---EEFVTPNTK ----WTFLPPSSPHMGGSWERLVQSVKKILGNMHL------P-RTP----TDEVL----- --RNS-----LMEVESIINSRP--------LTY------------V-------------- ----------------------PI-------------ES--------------------- ----------- >477/1-549 ---PTKRQVLRIVMKLYDPLGFVAHFVVQGKILMQE-IWRT-G----------T------ -NWDE-P-IAE--QLHELWTRWIEQYRKIN---E-VSVP--RCF--F------------- -GMFWPK-QVSSI-QIHV-FTDASVS-ACA-CVAYLR--VTV--DG------ESKC-S-- LIAA---------------------------KTKV-APL--R-T---------------- --------------------------------LSIPRLELQAAM-MGS-RLLQNICSA-- -L------T-VSI---QSR---FL---------WT------------------------- -------------------------------------WYLPLGVV-------INPK-K-P SKI-RMVWDAAAK-V-GG---VCFNDMLLKGPDLL--VSLMEVLLXFR---QGKI--AVC SDIREMFLRILIKNE--DXWSQC-----F------LXRSS---P-EX---------D-VQ VYVINVAMFGXTSSPCTAQFV-KNWN------------A----SXX-SXQY--P-RAVEA V-TKN--HYVDDF-LDSVN-S---VEEAVELVKQVX-DI-HAAA-------GFQFG-KVL SNXQ-EV-LDRL--GE-----TSSETSKQLPL-----------------------D-KDA XY--E-----------------RV--LG-------------------------------- -----VTW---------------------------------------------------- ----------------------------------------------------------PF IRPFTYVGVDYMGHFE-------------------------------------------- ----------------------------VK--VG-R-----S-IV-----KR-WIC---L -FTCLT--VRAVHLELAHSLSTKSC-----VMAFRRF-VNRR-GAPLEVFSDNGTNFVGA NRQLT-E-EMQ---RIKA-ING-D----------------------CA---STFTNACTQ ----WHFNVPAAPHMGGPWERMVKSVKVAMAAISD--S---P-HHP----SDEVF----- --ETI-----MLEAEGIVNSRP--------LTY------------V-------------- ----------------------PL-------------DA--------------------- ----------- >478/1-557 ---PTKREVLRTVMSFFDPMGLIAFFLIHGRTIMQD-IWAS-G----------I------ -GWDD-P-ITD--QIWMQWKEWIGLIPKLN---T-LQIP--RCY--L------------- -SEATES-SYSKL-QVHV-FVDASQA-AYA-CAVYFR--VET--PE------GPEV-S-- LVAA---------------------------KSKV-APL--K-L---------------- --------------------------------LTIPRLELQAAV-LGS-RLLNNVIAM-- -H------N-LPV---MKR---VL---------WS------------------------- -------------------------------------WYLPLGIV-------LNPK-K-P NKL-RMIWDAAAK-V-DG---VSLNTALLKGPDFL--TSLPSVIAKFR---LYRY--ALT GDIKEMFHRFFIRPQ--DRQFQR-----F------LFRDH---P-ET---------E-PV TYVMDVAIFGAACSPSSAQYI-KNLN------------A----KEF-EMSY--P-RAAEA I-IHR--HYVDDY-LDSFG-T---VEDAVKIGRQVK-NI-HAEG-------GFEIR-NFL SNDP-TI-AARV--GD-----ESLEAEKNIGE-----------------------D-KHE RV--E-----------------SV--LG-------------------------------- -----MKWMPNSDIFTFTV----------------------------------------- ----------------------------------------------------------PY VRPFTFVGVDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NV-----KR-WIA---L -FTCLT--IRAVHLEVVHSLSKESC-----VMAVRRF-VSRR-GAPAEIFSDNGTNFVGA SNQLK-R-E------IEE-LTH-H----------------------LA---STFTNTTTR ----WSFNPPGAPHMGGAWERMVRSVKVAIEGILE--A---Q-RRP----DDEVL----- --ETV-----VIEAEAMINSRP--------LTY------------I-------------- ----------------------PL-------------EA--------------------- ----------- >479/1-546 ---PTKRELLRILMSIFDPLGLVSHFLMILKVTLQE-VWRM-G----------L------ -KWDD-Q-IEG--RQLESWKAWISLLPKLE---E-LQIP--RCF--R------------- -RVTTVG-EHNQI-QMHT-FVDAGDN-GMA-AVVYLR--FEE--HG------YVEC-A-- LVGA---------------------------KTRV-APL--K-Y---------------- --------------------------------LSTPRSELQAAV-IGT-RLADTISKS-- -L------S-LPV---SQR---FF---------WC------------------------- -------------------------------------WYLPTFPV-------INPN-K-P GKI-RIVWDAAAM-A-HG---VSLNSVLLTGPDML--SSLVNVLNQFR---EYRY--GIC GDIREMFLQIGIRPE--DQFCQL-----F------LWNDS---I-ND---------GEPN TFMVSVMIFGARSSPTTAQFV-KNQN------------A----RRF-EVEF--P-LAVET I-EKK--HYVDDM-LASTE-T---EIEAIELAKSVK-HV-HAQG-------GFDIR-NWV SNSP-KV-LEAL--DE---SATG---KKSLNF-----------------------TAE-X AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF SRPFSHVGVDYFGPIE-------------------------------------------- ----------------------------VI--VG-R-----K-VE-----KR-WRV---I -LTCLT--IRALHIEVANTLSTSSC-----MMVLNNF-IARR-GTPVCFYSDRGTNFVGA SKELR-E-------ALRLLDSH-E----------------------IA---KEFTTPTTS ----WQFNPPASPHMGGSWERLVQSVKRNLTEVLK------C-KRP----TDEEL----- --RSA-----LTQIESVLNSRP--------LTE------------V-------------- ----------------------PV-------------DN--------------------- ----------- >48/1-550 ----TKRQVLSDVSRIFDPLGLLAPVVIQFKILFQE-LWVL-N----------L------ -DWDS-P-LPL--SLEDWYLKCKHDINTLN---E-LEVP--RYI--G------------- --NSTD-----TI-ELHA-FSDASIK-AYA-AAVYSR--VTLP-DG------NIQV-T-- LIAA---------------------------KTRV-APL-------K------------- ---T----------------------------QSLPRLELCGAL-LLS-RLINSVKAA-- -L-K----N-Y-N---VTV---YA---------WC------------------------- ------------------------------LTNDGRVFYMPHHPV-------L------G KKL-RVVFDGSFQDS-SG---QSLNDTLNVGPSIQ--RNLFDVCVRFR---LHKY--VFS ADIIKMFRQIWINKH--HRNYQR-----I------VWREH---P-SA---------PL-L HYQLCTVTYGTACAPFLAVRV-LEQL------------A----RDY-QHLY--P-TAARI L-LED--FYVDDV-LTGAD-T---EEKLLQYKQELI-QL-MSCA-------QLELG-KWI SNSN-RV-VDPETTIT------NNTSYSPL------------------------------ -ETTN-----------------KV--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------RQ AFPFANTGCDYAGPIT-------------------------------------------- ----------------------------LKVH--KGRN---PRKE-----KG-YIC---L -FVCLA--TSALHLELATDLTTDTF-----LAALRRF-ISRR-GKCSQMYSDNGRNFVGA KRVLN-E-------MQTLLKSD-EH------------------NNTVL---KALADEGIN ----WNFIPPHAPHWGGKWESAVRSVKLHLHRVIG--K-----NVL----TFEKM----- --HTL-----LAQIEAVVNSRP--------LFS------------T-------------- ----------------------SD--------TE-----------V-------------- ----------- >480/1-549 ---PTKRQILRIVMKLYDPLGFVAHFVVHGKILMQE-IWRT-G----------T------ -NWDE-P-IAE--QLHELWTRWIEQYRNIN---E-VNVP--RCF--F------------- -KNFWPQ-QVSNI-QIHV-FTDASVS-ACA-CVAYVR--MTV--NG------ESQC-S-- LIAA---------------------------KTKV-APL--R-S---------------- --------------------------------LSIPRLELQAAM-MGS-RLLQNICSA-- -L------T-ISI---QRR---FL---------WT------------------------- -------------------------------------WYLPLGVV-------INPK-K-P NKT-RMVWDAAAK-V-GG---VCFNDMLLKGPDLL--VPLMNVLLRFR---QGKV--AVC SDIREMFLRILIRDE--DKWSQC-----F------LWRTS---P-DE---------E-VQ VYVINVAMFGATSSPCTAQFV-KNWN------------A----SEF-SEQY--P-RAVEA V-TKN--HYVDDF-LDSVD-S---VEEAVTLVEQVQ-QI-HAAA-------GFQFG-KIV SNEQ-EV-LDRL--GE-----SSSSTSKPLPL-----------------------D-KDR TY--E-----------------RV--LG-------------------------------- -----VMW---------------------------------------------------- ----------------------------------------------------------PF IRPFTYVGVDYMGHFE-------------------------------------------- ----------------------------VK--VG-R-----S-IV-----KR-WIC---L -FTCLT--VRAVHLELAHSLSTKSC-----IMAFRRF-VNRR-GAPLEVFSDNGTNFVGA SRQLS-E-EMQ---KILA-INE-D----------------------CA---STFTNARTQ ----WHFNVPAAPHMGGPWERMVKSVKVAMAAISD--S---P-HHT----SDEIF----- --ETI-----MLEAEGIVNSRP--------LTY------------V-------------- ----------------------PL-------------EA--------------------- ----------- >481/1-548 ---PTKRELLSVLMSMYDPLGLIASFLMPLKLLLQE-VWRS-G----------I------ -TWDE-P-IGD--LQLQRWKSWLTYLPLAG---S-VRIP--RCY--N------------- -LTSTHG-DQIDI-ELHT-FVDASET-GYC-AVSYLR--FQL--AD------SIRC-V-- LVGA---------------------------KTRV-APL--K-F---------------- --------------------------------ISIPRLELQAAV-IGS-RLAKNIEEG-- -H------S-IKI---GRR---CF---------WT------------------------- -----------------------------------RVWYLPIFPV-------FNRN-K-P NKV-RVVWDAAAS-V-AG---TSLNSVLLKGPDQL--KPLPFILYKFR---ERPI--AIC GDIEEMFHQVKMCVD--DQQSQR-----F------LFQDN---L-NA---------AEPD EYVMTVMTFGATCSPSSAQFI-INKN------------A----ERF-QKQL--P-TAAEA I-REN--HYVDDM-LASVN-S---EAEAIQLAEDVH-FI-HQQG-------GFKMR-GWI SNSP-TV-MRAL--NS---SEIP---ERNLDL-----------------------NTE-H AL--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF IRPFSYIGVDYFGPYQ-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -VTCLT--VRAIHVELVHSLNADSC-----IMALRSC-FARR-GVPVQIISDRGTNFIAS EKQLK-Q-------ALAVVDQD-K----------------------MI---KEFTSASTS ----WVFNPPATPHMGGSWERLIQSVKKILAEIHL------P-HLP----RDEVL----- --RSS-----LIEVENIVNSRP--------LTH------------V-------------- ----------------------PI-------------EF--------------------- ----------- >482/1-566 ----TKRSVLAVIATLFDPLGLLGAAITSAKIFMQL-LWTL-Q----------D-SDNQR IGWDQ-P-LPS--TVGEIWRNFHQQLPLLN---E-IRID--RCV--I------------- --IP-K-AV--SY-ELHC-FTDASEK-AYG-ACLYVK--SENV-AG------EVKI-R-- LLTS---------------------------RSKV-APL-------K------------- ---C----------------------------QTIPRLELCGAL-LGA-HLFEKVAQS-- -I-R----F-T-----GKI---YF---------WL------------------------- ------------------------------EMDSTKRCYLPHHPV-------IKEA-STT TKV-RVVFDASCKTA-TG---KSLNDVLLAGPVVQ--EDLRSIILRSR---TKQI--MLV SDVEKMFRQINIDTK--DRPLQC-----I------LWRYS---P-SD---------PP-L SYELNTVTYGTKPAPFLATRT-LQQL------------A----LDE-EKRF--P-LAARA I-IDD--TYMDDV-ITGAD-G---VETANEMRRQLE-AM-SSSG-------GFRLR-KWA SNCP-AV-LDGVHEEDLAIRTSEG-I-ILD---------------------------P-- -DPSI-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV SRPFLRTGVDYFGPLF-------------------------------------------- ----------------------------VRPA--PRRP---P-V------KA-YVA---I -FICMC--TKAVHMELVSDLSTDRF-----LQALNRF-IARR-GRCTDIFSDNGTNFVGA RNKLQ-D-------LLKVLKDS-KH------------------HEIVA---NELAREGIQ ----WHFNPPSAPHFGGLWEAAVRSAKHHIVKVIG--E-----NPA----SPEDL----- --CTL-----LAQIEACLNSRP--------ITP------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >483/1-557 ---PTKRQMLRCLMSFFDPLGLLSAVLIHGRILLQD-VWRA-G----------T------ -QWDE-P-VTD--DIWERWIRWVEALKRIN---N-IHVP--RCY--F------------- -QQATSV-SYRGL-QLHV-FVDASEV-AYS-AVAYFR--TLNS-EG------IPVC-A-- LVAG---------------------------KAKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-LGA-RLMRFITES-- -H------T-VEI---SKR---FL---------WS------------------------- ---------------Q---------------ADPRRIWYLPLGAV-------VNPK-K-P GKV-RLIWDAAAT-V-NG---ISLNSLLLKGPDQL--TSLPAILSRFR---QFSV--GVS ADLQEMFHQIGIRES--DRHSQR-----F------LWRKN---S-SE---------Q-PS VFLMNVATFGSSCSPASAQFV-KNKN------------A----EEF-ADLY--P-EAAQA I-IHN--HYVDDY-LDSFE-N---AEDASRVSQEVK-MV-HSRG-------GFHLR-NWL SNEQ-KV-LESL--GAH----AATE-TKSLFM-----------------------D-KTS DC--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------AC VRPFSYVGLDFFGPFL-------------------------------------------- ----------------------------VK--VG-R-----S-YL-----KR-WIA---L -FTCLT--IRAVHVEVVFSLTTKSC-----IECIRRF-ICRR-GVPNEIYTDNGTNFKGA ARLMK-E-QQE---MIRE-INE-N----------------------LA---GTFTSTTTK ----WLFIPPASPHMGGAWERMVRSVKTAMFAAYE--G---N-RKL----TDEGL----- --LTL-----ITEAEAIVNSRP--------LTY------------M-------------- ----------------------PL-------------ES--------------------- ----------- >484/1-552 ---PTKRIVMSCVMSFFDPLGLLSTFTFYGKLLIQD-LWRS-G----------C------ -SWDQ-P-IDD--ECAEKWNHWIRRLPEVE---M-VRIP--RYY--F------------- -RGGRCL-DYSNL-QLHV-FVDASED-AYG-AAAYIR--IETA-DR-------PLC-S-- LVMS---------------------------RSKV-APL--K-H---------------- --------------------------------LSIPRLELQAAV-LGA-RLANSVREI-- -L------S-LEV---KQQ---FM---------WS------------------------- -------------------------------------WYVPLNIV-------FNPR-K-- KKF-RLVWDARAE-V-KG---VSLNSKLLKGPDML--TALPAVICKFR---EREV--GFG ADIKEMYHQLRIREE--DKRAQR-----F------LFRND---P-SE---------K-PT VYVMDVATFGSTSSPCSAQYV-KNQN------------A----KEF-AGQF--P-AATVA I-VEN--HYVDDY-FDSAD-T---VEEAVERAKEVR-YV-HSKG-------GFELR-NWV SSSE-KF-LVAL--GE-----RKEDQCVXFSE-----------------------D-KES GS--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PN LPPFSHTGVDYCGPVT-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-YIC---L -FTCMT--TRAVHLEIAHSLTTQAC-----LMAIRRF-VCRR-GKPLEFYSDNGTNFQAA SKAI-----------VQQ-IGI-K----------------------CE---DEFTDSRTR ----WNFNPPSAPHMGGVWERLVRSVKAALTV-LN--D---G-RSL----TDEVL----- --LTT-----IAEAEDLINSRP--------LTY------------V----GLEPGADEAL T---------------------PN-------------HF--------------------- ----------- >485/1-579 ----TRKIVLSEIAKFFDPLGLGGPVVTAAKLIFRE-VGLL-N----------L------ -DWDD-P-VPD--TIAERWRSFRSQLPALN---D-LKVP--RWI--I------------- --SEGSKLV-----ELHG-FADASDQ-AYG-TCLYTR--LVLP-NG------AVKM-H-- LICS---------------------------KSRI-LPK--K--TGK------------- ---TKP--------------------------ITTPRAELLAAL-LLS-REMTKVINS-- -VD-------IIF---DRV---TL---------WS------------------------- ------------------------------SEHPASSYYLPHHCV-------LRPS-SVT TKL-RVVFDGSAKTS-TE---ISINDTLKVGPIMQ--NDLVSILLNFR---CYRF--VFT ADIPKMFRQILVHTE--DAPFQR-----I------LWRDD---R-SQ---------LL-K TFELCTVTYGLASSPFHATMT-LHQL------------A----EDA-KEDY--P-TAAPV L-KKS--FYIDDA-LCGAH-T---TEEARSLCQELL-QL-LHSG-------GFDAH-KWC SNNQ-AI-LEGIPRNLWGTTY------DVE---------------------------DAA DNAVV-----------------KT--LG-------------------------------- -----VVWNASQDWF----------------------------SFRI------------- ----------------------------------------------------------QP SPAFFHTGVDYAGPFS-------------------------------------------- ----------------------------IKSLTQARKP---MIT------KG-YIC---L -FVCLS--TRAIHLELVSSLTTDAF-----LATLRRF-IGRR-GPVSKIYSDNAKNFVGA EAELE-Q-------LSNLFSAE-QH------------------IKALE---EFCGSQSIT ----WSFIPPRSPHFGGIWESGVKSVKHHLKRVVG--N-----QKL----TFEEM----- --STV-----LVQIESVLNSRP--------LIP------------C-------------- ----------------------SD--------DPS--D-------L-------------- ----------- >486/1-529 ---PSKREVLKVLMSIFDPLGLIAHFLIYLKVLLQE-IWRS-G----------A------ -QWDE-E-IND--ALFAKWQTWLRVLPEVE---S-VQIP--RCY--N------------- -LQDFDR-I---I-ELHT-FVDSSEN-GFA-AVSYLR--FSD--GT------HVEC-I-- LITA---------------------------KTRV-APL--K-F---------------- --------------------------------QSIPRLELQAAV-LGA-RLAQTIAES-- -L------S-IRI---TRR---CF---------WT------------------------- -----------------------------------RVWYLPVFPV-------INPN-K-P GKV-RIVWDAAAK-T-YG---ISLNSALLKGPDQM--GSLFSILLQFR---EHRI--GLT GDIREMFHQVEIREE--DRSCQR-----F------FWKDE---Y-GE---------V--A VFEXCVMTFGACCSPSSAQFV-KNLN------------A----ERF-IGKY--P-QAVDV I-IKR--HYVDDM-LVSVK-T---EKEAIRIANQVK-EI-HSQG-------GFEIR-NWI SNST-TV-LRSL--GE---DEAK---IKNLDL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY SRPFTHVGIDFFGPME-------------------------------------------- ----------------------------VV--IG-R-----R-IE-----KR-WGM---L -ATCMT--TRAVHIEVAHSLNTDSC-----LMAIRNM-IARR-GIPRYIYCDRGTNFVGT NREIS-R-------IKKELDHE-E----------------------MM---KEFTSSETT ----WCFNPPSSPHMGGCWERLIRSVKNSLKALNL------P-RRP----SDEVL----- --RNA-----LTEIENTLNTRP--------LTH------------V-------------- ----------------------PI-------------ED--------------------- ----------- >487/1-542 ---ATKRVILSRISQLFDPLGLIAPVVVKGKMLIQK-LWVI-E----------C------ -SWDE-K-VPS--EIRREWEKLYDQLPLLS---K-FRID--RYA--F------------- --QP-N-ST---I-QLHS-FADASES-AYG-ACVYAR--SVDA-EG------NIRV-Q-- LLAA---------------------------KSRV-APL-------Q------------- ---R----------------------------LSITKLELCAAV-IAA-QLHSRVVEA-- -L-Q----M-N-I---DES---FF---------WS------------------------- -------------------------------------------------------S-STT TKT-RVVFDGSSKTS-SG---FSLNQALCVGPTVQ--DELLDLVIRNR---KFPV--AMA ADVEKMYRQVLVHPK--DTPLQK-----I------KYRFK---P-TE---------PL-Q SYELLTVTYGLAPSSFLATRA-LQQL------------A----NDE-GHAY--P-LAAPV L-KKS--FYVDDF-IGGAN-S---IVEAIKLREELT-EL-LSKG-------GFPLR-KWI SNKL-EV-LQGLPADQIGTQS--T-Y-RFD---------------------------P-- -GETV-----------------KT--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------TV SRPFEITGVDYAGPLY-------------------------------------------- ----------------------------LKAI--HKRA---DPA------KV-YIC---L -FVCFA--TKAVHLELVGDLSTPAF-----ISALRRF-VARR-GRPRHLHSDNGKNFIGA KNDLH-H-------LYKMLTDD-AQ------------------VDRIT---RFCAEEEIV ----WHLNPPKAPHFGGLWEAAVKVAKKHLHRQLG--N-----SRL----SYEDL----- --STV-----LAEIEAAMNSRP--------LVP------------M-------------- ----------------------TE--------DPN--D-------F-------------- ----------- >488/1-545 ---PTKREVLRVLMTIFDPLGLIAPFLMFLKILLQE-IWRS-G----------I------ -QWDD-K-IDE--NTFAKWRSWLQVLPEVE---K-VRVP--RCF--R------------- -SQLDSP-YD-DV-QLHT-FVDASEN-GMA-AACFLR--FVR--DE------AVCC-W-- LVAA---------------------------KTRV-APL--R-Y---------------- --------------------------------HSIPRLELMAAV-IGT-RLSHTVVDS-- -L------S-FKV---NKR---FY---------HS------------------------- -----------------------------------RVWYLPTFPV-------TNPN-K-P GKV-RIVWDAAAK-A-FG---VSLNSALLKGPDHL--SSLFTVLTRFR---EHPV--ALT GDIREMFHQVLIREE--DQQCQR-----F------YWRDE---D-GA---------L--S VYVMCVMTFGACCSPSSAQYA-MNLN------------A----KRF-DQEY--P-AAVEI I-GKQ--HYVDDM-LVSVD-N---EEEAIKLADDVR-FV-HSQG-------GFEIR-NWA SNSP-RV-LEAL--CG---TNAQ---EKNLDL-----------------------SSE-M AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF ARPFSHIGVDYFGPIE-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGM---L -VTCLT--TRAIHIEVVHTLSTGSC-----IMGLRNF-VARR-GTPKTIYSDRGTCFIGA SRELE-A-------VTTVINQE-E----------------------IM---KEFGGTETT ----WKFNPPASPHMGGSWERLIGVVKRNLMAIRP------P-HKP----NDEVL----- --RNL-----LTEVENTVNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >489/1-552 ---PTKREALRVVMSPFDPAGLLCFFLIHGKMLIQE-AMES-K----------T------ -DWDQ-R-IPM--QLKEMWTRWTNMFERLD---E-VRVP--RCY--F------------- -PQHGQN-EIVDL-QLHI-FVDASEE-AYA-CVAYFR--AEFV-DG-------IEM-A-- LIGG---------------------------KAKV-APL--K-A---------------- --------------------------------LSIPRLELMAAV-IGV-RLLKTIRNG-- -H------S-MKI---GKT---TM---------WS------------------------- ---------------E---------------ADPMRTWYLPLGVA-------INPK-K-P SKI-RIFCDAAAK-V-DG---ISMNTMLLKGPDLL--NTLLDVLFGFR---EKRI--ALC ADLKEMFHQIQIRPE--DRHAQR-----L------LWRED---P-SQ---------T-PD VYLMDVATFGATCSPCSAQFV-KNKN------------A----EEH-APEY--P-EAAEA I-IRK--HYVDDY-LDSAD-S---VDEAVKIASDVR-HV-HSLG-------GFHLR-NWL SNSK-EV-LARV--GE-S----NAIAEKSLQL-----------------------D-KNS ST--E-----------------RV--LG-------------------------------- -----MFW---------------------------------------------------- ----------------------------------------------------------PY ERPFSYVGLDYFGPIL-------------------------------------------- ----------------------------VR--VN-R-----S-TV-----KR-WIA---L -FTCLT--TRAVHLEVAHSLSTESC-----KQAIRRF-IGRR-GAPVEIRSDRGTNFVGA NNDLR-K-E------MME-MDQ-Q----------------------LA---ETFTNTXTR ----WVFNPPAAPHMGGAWERLVRSVKTAIAA-IQ--T---T-EIP----KEEAL----- --ATF-----XVEAESVVNSRP--------LTF------------X-------------- ----------------------PL-------------ET--------------------- ----------- >49/1-548 ---PTKRELLQVLMSMYDPLGFISCFTIELKILLQE-VWRS-G----------I------ -GWDT-G-LPD--ALLPKWIRWKRILTTIA---G-LTIP--RCY--F------------- -NSSDQI---HDV-QLHT-FVDASEL-AYA-AVCYLR--IRQ--GE------RTYL-S-- FVAS---------------------------KAKV-APL--S-P---------------- --------------------------------LSIPRMELQAAV-IGA-KLSNRIQRN-- -P------S-LSI---NSS---CY---------WS------------------------- ----------------------------------RRTWYLPTFIT-------KNPN-K-P EKV-RLVWDAAAQ-S-GG---KALNDYIWSGPDLL--NSLFDLLLSFR---VGRV--AIC GDIAEMFHQIRVRPA--DTHAQR-----F------LWFDS---KSER---------QEPN VYVMEALTFGINCAPCIAHFI-RDKN------------A----DRF-CQQY--P-QAAQA M-KDY--HYVDDF-IYSGD-N---YVEVGNIATQVR-DI-HAAG-------GFHIR-NWS SNSK-EV-LRIL--KS----------DSLLPE-----------------------A--VE ITATE-----------------K------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------AY QRPFTYVGIDYFGPFL-------------------------------------------- ----------------------------VA--VG-R-----R-SE-----KR-WGV---I -FTCLT--IRAVHIELACSLDTASC-----IMCIRNF-INRR-GTPREIYSDNGTNFKAA EKIIC-D-------KAQTINFN-A----------------------VQ---PAF--DDIK ----WKFNPPAAPHMGGAWERLVRSVKTVLYAICP------A-RKF----TSEGL----- --QSA-----LWEVEFILNSRP--------LTF------------V-------------- ----------------------SL-------------DSKDDEAITPNHL---------- ----------- >490/1-527 ---PTKRQVLSEIAKIYDPLGLISPVVVLAKIVMQK-LWIS-K----------L------ -NWDD-Q-LDE--GLMNEWEKFLTSLPTSE---Q-IHIP--RQI--L------------- --SS-K-AA--YY-ELHG-FADASQK-AYG-ACVYVR--SIFS-DG------TASM-Q-- LVSA---------------------------KSKI-API-------S------------- ---P----------------------------LTIPRKELLAAL-LLT-RLVSKV-EA-- -ALE----M-N-F---NSI---VL---------WS------------------------- -------------------------------------WYLPHHAV-------LRPS-NST TKC-RVVFDASAKV--SG---LSLNDVMMTGSNVQ--SDLLSIILRFR---KHRY--VMS ADVAKMYRQIIVDPA--FTPLQR-----I------FWRKS---P-QD---------RL-R VLELTTVTYGTAAAPFLATRA-LLQL------------A----RDE-RERF--P-LASKV V-EKN--IYIDDA-LFGSD-D---FQETCELRDQLI-GL-LQCG-------GMHLH-KWS SNTS-RL-LL-------------------------------------------------- ------------------------------------------------------------ --------------------SI-------------------------------------- ----------------------------------------------------------TP APVFERVGLDFAGPIY-------------------------------------------- ----------------------------IK--QSVRKA---IPV------KG-YIC---V -FICMV--TKAIHLEAVEDLSTDSF-----IAAFQRF-VSRR-GYPKEVFSDNGTNFIGA RSALR-E-------LYQLFKEE-TT------------------QKRIF---EYCQAKQIE ----WKTIPPNAPHFGGLWEAGVKSCKSVLKRVYQ--N-----TSL----TLSGL----- --STL-----LCQIEAILNSRP--------LYS------------Q-------------- ----------------------SN--------D-----------------PTEP------ ----------- >492/1-546 PTELSKRTILSFIASHYDPCGYISPIILPLKLFLHE-LWS-EK----------L------ -AWDE-K-LPE--NLINSWNNIINDWQIGT-----VQIP--RLI--S------------- ----TLPVDNRTY-QLHC-FSDASLT-AMG-CAVYLR--TLNPISK------ISQV-S-- LLFS---------------------------KTKI-KPL--K----SNNK---------- --------------------------------LTVPRLELIAAK-IGT-NALVYVHKE-- -L------S-TLNI---TV---PL---------FL------------------------- ------------------------------KNFHPPLHYLPHHAV-------INP-K--- -KV-RIVYDGSAKLP-NS---FSLNDCLHPGPVIL--PELVGVLLRMR---IPKI--VIV CDIQKAFLQVSVHPN--HRDSIR-----F------LWLKN---I-QE----PLSLENL-Q IYRFTRVPFGLSPSPFLLAAT-ILHH------------L------RLNPS---Q-LT-EE I-LPN--IYVDNI-LFGAE-T---VLEATEKCESLI-NL-FSTA-------NMKLR-EFI SNIP-ET-IDHIPLDDK--L---------------------------------------- NGPKQ-----------------KF--LG-------------------------------- -----VGW---------------------------------------------------- ----------------------------------------------------------EL LRPFLSVGLDYCGPLR-------------------------------------------- ----------------------------I----FDPNQ---TERKRKPLTKKYWIV---L -WVCLS--SRALSLDLVPDLTNQSF-----LLAFRRF-VAKC-GLPKKLFSDNAPTFTSF QKALE----------------------------------------------PQFGIKNIE ----WDFRAPLAAWKSGHYERLVALIKYHLRRSLS--I-----GAIPKLFSLDHI----- --TTV-----IAEIETIINSRP--------IAY------------D-------------- ----------------------S------------------------------------- ----------- >493/1-545 ---PTKRQLLQVVMSIFDPLGLISLVVVHGKILIQN-VWRA-N----------I------ -AWDE-K-INS--EQLSEWRRWIKLLGQLD---S-VRIP--RCY--F------------- -PEYLPE-SFGTL-QLHV-LVDASEE-AYA-AAAYFR--IVD--RT------QVRC-V-- LVSS---------------------------KTKV-APL--K-P---------------- --------------------------------LSVPRLELQAAL-LGA-RLAKSVTEN-- -H------T-LCI---KQQ---FF---------WS------------------------- -------------------------------------WYLPLGVV-------VNPK-K-P GKV-RIVWDAAAK-V-KG---QSLNSALLAGPDLL--TSLPSVLSRYR---QRQV--AIS GDIREMFHQFQIRPE--DRQAQR-----F------LFRSD---L-SK---------A-PD TYVMNVATFGVTCSPSAAQFI-KNRN------------A----KDF-ETEY--P-AAATA I-VHK--HYVDDY-LDSLD-T---VEEAVDMALQVK-EV-HAKA-------GFHIR-NWM SSSK-EV-LSRV--GD-SAEE----QVKSFSA-----------------------H-ATS SS--E-----------------RV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PR VKPFSFVGIDYFGPLL-------------------------------------------- ----------------------------VV--QG-R-----H-EV-----KK-WVA---L -FTCLT--IRAIHLEIVSSLSTECC-----KMAIRRF-ISRR-GAPSEIYSDRGTNFVGV SGELR-E-Q------LRS-INT-E----------------------LA---TTFTNTVTQ ----WRFNPPAAPHMGGSWERMVRSVKCALAS-LS--V---E-RKP----SEEVL----- --VTL-----LVEAESVVNSRP--------LTY------------M-------------- ----------------------PI-------------ES--------------------- ----------- >494/1-553 ---NTKRQLLSDASRLFDPFGWLSPCIVKIKILFQQ-LWLH-D----------L------ -TWDD-P-LPS--AIEEEWVSIKNNLQALE---Q-LRIP--R-W--V------------- -ANHKGG--M----QLIG-FSDASES-AYA-AVVYGR--SVDS-NG------KVHI-T-- LIAA---------------------------KTKV-API--Q-Q---------------- --------------------------------VTLPRLELNAAV-LLT-ALVKKISSA-- -L------N-HLK---LEV---NA---------WT------------------------- -----------------------------------ECFYLPHHAV-------HKAD-SLT TKL-RVVFDGSCSSS-SG---VSLNDRLLVGPNNT--ENLLDVLCRFR---TYPI--VFV SDIEKMYRQVRVSED--QADFLR-----V------VYRKN---P-EE---------PV-Q HYRLLTVTYGTSCAAYLATES-LRQA------------A----RDS-ATKY--P-VAADR I-LKG--FYVDDL-MSGAN-T---VDEARTLVNEIS-TI-LNGA-------GFALR-KWS SNVP-EL-IEDITDSQQGPIPIQF-TSELD------------------------------ ---SV-----------------KA--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------MP VRAFVHVGVDYAGPIT-------------------------------------------- ----------------------------VKSG--NPRK---PLLT-----KG-YIV---V -FVCLS--TKAIHLEAASNLSTATF-----IEALKRF-IARR-GLCTEIWSDNGTNFVGA DRQMQ-D-------FFQSTEFE-T---------------------QAN---RFSSNVGIK ----WTFIPPSAPHMGGLWEAAVKSAKLHLYKVLS--R-----GPH----TYEDL----- --CTI-----LAQIEACLNSRP--------LCA------------I-------------- ----------------------SN--------SPD--D-------Y-------------- ----------- >497/1-556 ---PTKRSILSCISRLFDPLGLIAPVIVKSKLLMQE-LWLL-S----------C------ -GWDD-A-VPD--SVRQKWDGIRSELPTIS---T-YRAD--RYA--F------------- --LP-N-AS---V-QLHV-FSDASEV-AYG-ACIYAR--CEDS-DG------RVRI-S-- LLAS---------------------------KSRV-APL-------K------------- ---R----------------------------VSLPRLELSAAV-LGA-HLYERIRKS-- -I-H----I-E-I---AAS---YF---------WS------------------------- -------------------------------------------------------S-STT TKV-RVVFDGSAKTS-TG---YSLNEALCVGPVVQ--DDLLDIMMRFR---TYKV--AVV GDIAKMYRQVLLHPE--DRPLVR-----I------FFRFS---P-QS---------PI-R TYELQTVTYGLAPSSFLATRT-LHQL------------A----DDE-GHKY--P-LGGPA L-RKN--FYVDDF-IGGAQ-N---VQEAIQLRLQMS-EL-LAKG-------GFELR-KWT SNEL-EV-LRGLKDEQIGTQS--S-L-QFN---------------------------P-- -NETI-----------------KA--LG-------------------------------- -----ICWEPEADTLRFDS--------------------------HIS------------ ----------------------------------------------------------TP SRPFSVVGIDYAGPFY-------------------------------------------- ----------------------------LKPI--HKRA---APA------KS-YLC---L -FVCFS--TKAVHLELVCELSTSAF-----LAALRRF-ISRR-GRPIHIHSDNGKNFEGA KNEIV-Q-------LFAMLAAA-HH------------------IDEIN---SFCASEGIT ----WHLTPPKAPHFGGLWESAVKVAKKHIYRVIG--S-----SRY----TYEDF----- --STL-----FAQIEAVMNSRP--------LLP------------M-------------- ----------------------TD--------DPN--D-------L-------------- ----------- >498/1-547 ---PTKRVLLSVVMSFFDPLGLWAPFTVLGKIIVQD-LWRN-G----------C------ -SWDE-I-IDE--HSAKKWYRWIALLPSLQ---A-MEIP--RCY--F------------- -ADVKAS-DYQDL-ELHV-FADASEE-AYG-CVAYFR--VLVK-GE-------PRV-A-- LVSA---------------------------KSKV-APL--Q-Y---------------- --------------------------------MSIPRMELLAAV-LGA-RLAAFVKSN-- -H------S-VQV---QRV---FY---------HI------------------------- -------------------------------------WYLPLNVV-------LNPK-K-P GKV-RLVWDAAAS-V-QG---KSLNSELLKGPDLL--SSLPSVLCPFR---ERPV--AFG GDIAEMYHQLRIRSS--DKSAQR-----F------LYRPN---A-SG---------P-PI TYVMDVATFGATSSPCSAQFI-KNRN------------A----QDY-AEEY--P-DAVDA I-INK--HYVDDY-LDSTF-T---VSEAIRRAEEVT-YI-HSNA-------GFHIR-NWV SNSE-EF-QQHF--GR-----KPENHIVHFAS-----------------------D-KSS NTSME-----------------RI--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PQ IRPFSYVGVDYFGPVV-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WVC---L -FTCLV--TRAIHMEIAYSLSSQSC-----AMAIRRF-ICRR-GTPLEIFSDNGTNFQAA SKEFI-Q-E------IRC-IEM-E----------------------CA---DIFTDARTR ----WNFNPPAAPHMGGVWERLVRSAKEALKA-LH--N---G-GKL----SDEIL----- --LTI-----LSEAEDMVNSRP--------LTY------------V-------------- ----------------------PQ-------------ES--------------------- ----------- >499/1-549 ----TKRGVLKLLMTLFDPHGLISNFLIHGKIVIQD-LWRS-G----------V------ -SWDE-A-IPQ--EIYARWKRWINQLSCLE---N-VKVP--RCY--F------------- -PSYNVE-DLQTI-ELHI-FVDASES-AYA-CVAYFR--IIE--RG------EPRC-A-- FVSS---------------------------KAKV-APL--K-S---------------- --------------------------------LSIPRLELQAGV-IGS-RLAKSIRDN-- -H------T-LPI---SRT---VF---------HS------------------------- -------------------------------------WYLPLGIV-------TNPK-K-P GKV-RIIWDAAAK-V-NG---VSFNSMLLKGPDML--TSLPSVLFRFR---ERKF--CVT ADIREMYHQVNIRPA--DRSSQR-----F------LYRSK---P-SD---------V-LE TYIMDVATFGSTCSPCSAQHV-KNVN------------A----EEW-KKVY--P-EAASA I-VDN--HYVDDY-LDSRD-T---EEELANLAIDVR-TV-HSKA-------GFDLR-NWR SNSM-KV-LRRV--GE-EPAK----TGKIIGE-----------------------D-KLN QT--E-----------------RV--LG-------------------------------- -----MAWLPTDD----------------------------------------------- ----------------------------------------------------------PF ERPFSRVGVDYCGPFT-------------------------------------------- ----------------------------IK--VL-R-----S-NV-----KR-WVA---L -FTCLA--TRAVHLEVVTSLSTESC-----KLAFRRF-IDRR-GAPSEIYTDNGTNFQGT CRELA-K-Q------LAS-VNQ-G----------------------LA---ETFTDANSK ----WFFIPPASPHMGGVWERMVRSIKAAMNG-IH--H---L-RPP----TEEVF----- --QTL-----CTEAESMVNCRP--------LTY------------V-------------- ----------------------PL-------------DT--------------------- ----------- >5/1-553 ----TKRLVLSQLSRIFDPLGWLAPVTIQGKCFIQE-LWKL-P----------M------ -TWDV-E-LES--NLANWWMEYAKGLSDLE---E-ISIS--RWT--G------------- -CSKGI-------MELHG-FCDASEK-AYA-AAVYTK--V------------GGRV-T-- LLAA---------------------------KSKV-NPI-------K------------- ---NR---------------------------KTIPKLELCAAH-LLA-KLLAKVQAI-- -W------S-N-K---ITT---HA---------WS------------------------- ------------------------------------KYYLPHQAI-------IRPG-SLT TKL-RVVFDASAKTT-NG---LSLNDVIIAGPKIQ--KDIFDILIKWR---KWQY--VMV ADIEKMYRQIKVAEK--DQEYQY-----I------LWRDD---P-KL---------PI-S EFKLTTVTYGTSAAPFLAVRC-LREL------------A----DRF-CQED--S-VLAET I-RDD--FYMDDL-ITGGD-T---VNECYELQRKLR-QV-MEKA-------GMHLR-KWV ANDE-RI-LADIQDDGATEKI------------------------------------CIE ENESI-----------------KT--LG-------------------------------- -----LQW---------------------------------------------------- ----------------------------------------------------------TA DYSFQNTGIDYAGPFQ-------------------------------------------- ----------------------------IRCS--KGRG---QKTY-----KG-YIC---V -FVCMA--TKAIHLEAVSDLSSDKF-----LEALRRF-FARR-GKSENIYSDNGTNFVGA SRVLD-K-------EFVAAIKN-NN--------------------ELA---PTLEKEGIK ----WHFIPPGSPHMGGLWEAGVKSVKHHLKRVIG--E-----NSF----TYEEF----- --ASL-----LCQIEAVLNSRP--------LVT------------V-------------- ----------------------RS--------END--G-------EDILTPGHF------ ----------- >50/1-561 ----TKRSILRTVMTIFDPLGLLGFYIIQAKIILQD-VWRS-A----------V------ -GWDE-Q-VEE--SERQRWMIWARQLQNIE---E-LRVP--RYL--G------------- -LTKETS----NI-QLHI-FTDASIN-AFA-AVAYIR--IEQ--RG------EVRC-T-- LLAS---------------------------KTRV-APL--K-P---------------- --------------------------------ISIPRMELMAAI-LGL-RLAKLITQE-- -L------S-VEV---KRR---VF---------WT------------------------- -----------------------------------RSWYLPVFVT-------KNPN-K-- GKL-RLVWDAAAK-V-EG---IALNSMLLKGPDQL--PSLVGVISRFR---EKSI--GIC GDIREMFHQVRIRSE--DQSSQQ-----F------LWRYG---D-TS---------REPD RYVMSVMTFGASCSPAAATYV-RDRN------------A----ERF-IEEQ--R-EEVEA I-LRN--TFVDDW-LQSCD-S---EDEMVRLALAVR-NI-HKEG-------GFEMR-GWI SNSS-TV-MRAL--SG---DGDH--QERPIEM-----------------------TDS-T RR--E-----------------RV--LG-------------------------------- -----MWW----HDYFTFVNKFPNDIYDKSG----------------------------- ----------------------------------------------------------IN ELPFTNTGIDYFGPLE-------------------------------------------- ----------------------------VN--VG-R-----R-RE-----KR-WGV---L -FTCLT--VRAVHIELANSLSTDAF-----MLTLEMF-VARR-GVPKRIVSDNGTNFRGA SRLLR-E-------EIERILPN-E----------------------LE---TKY--PQIE ----WSFIPPGAPHMGGAWERMIRSVKSILAEILE------E-THV----QEPVL----- --RTA-----LAKIENMLNSRP--------LTY------------V-------------- ----------------------PL-------------EC--------------------- ----------- >500/1-559 -----RRTVLSDTAKLFDPLGLVGPVVVLAKIFVQS-LWRT-S----------N------ -SWDD-P-LDD--SQQQYWLTFRNSLDALS---S-ISVP--RWV--A------------- --FANA-PV--NV-ELHG-FCDASIR-AYG-ACLYIR--TVSS-DG------SIAV-R-- LLTA---------------------------KSKV-APL--G-DSKR------------- ---QKT--------------------------VSLPRLELSAAL-LLS-HLYHKVNSS-- -V-A----I---S---TRP---FF---------WS------------------------- -----------------------------------PSYYLPHHGV-------EKAD-STT TKL-RVVFDASCRTD-SG---VSLNQALLVGPVVQ--DDLYAISLRFR---MRQY--AIV ADAEKMYRQIRLHPS--DFPLHR-----I------FWRQS---P-SE---------PL-K TFELTTVTYGTASAPYLATRC-LLEL------------S----RQG-SKEF--P-QAAEV L-AED--FYIDDM-LTSVD-D---EEDGAELCKQLR-NL-LQSG-------GFSLR-KWA SNSE-DI-LSVIPPQLRDERS--M-L-TLD---------------------------T-- PST-I-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------TP TLPFLNTGVDLCGPFQ-------------------------------------------- ----------------------------YRKV---RKS---LPT------KC-YIA---I -FVCLA--TKAIHVEMVYDLSTAAF-----IAAMRRF-IARR-GKPSSIHCDNARNFKGA ARELA-N-------LAKQFHSQ-QH------------------QAAVV---DHCANDGIM ----FKFIPPRSPNFGGLWEAAVKSFKQHLRSTIG--N-----SVL----SQDEF----- --VTL-----LTRIEACLNSRP--------ITP------------I-------------- ----------------------SA--------DPN--D-------L-------------- ----------- >502/1-526 ---PSKREVAKVVMSLFDPLGLIAFLLVHGKVLIQE-LWVK-G----------T------ -GWDQ-K-IPQ--DADVRWRRWVDSLSQLE---R-LRIP--RYY--F------------- -PSSLPK-NFICL-QIHL-FVDASDA-AYA-AVVYFR--LQT--EQ------GTQV-A-- LVGA---------------------------KTKV-APL--K-A---------------- --------------------------------LSIPRLELKAAV-LGI-RLMDTIQCQ-- -H------T-YPI---TQR---FC---------WT------------------------- ---------------S---------------VEPNRIWYLPLGVV-------INPR-K-P GKV-RLIWDAAAK-V-GD---ISFNSQLLKGPDLL--TPLPKVLYQFR---QYPV--AVT GDIMEMFHQINIRSP--DCQSQR-----F------LFREN---S-AD---------I-PK IYVMDVATFGSTCSPASAQYV-KNRN------------A----EEF-ATEY--P-RAAAA I-VNK--HYVDDY-LDSFE-T---ISEAVDVVNEVK-LV-HSKG-------GFTLR-RFL SNEP-AV-LRGI--GE-------------------------------------------- ------------------------------------------------------------ -----------EV----------------------------------------------- ----------------------------------------------------------AF IQPFTYTGLDYFGPIL-------------------------------------------- ----------------------------IK--LG-R-----S-NV-----KR-WVA---L -FTCLT--IRAVHLEVVHSLSTVSC-----IMAVQRF-VARR-GQPREFWSDNATCFQGT SNELR------------M-HNI-T----------------------LA---EKFTTSQCT ----WKFIPPSTPHMGGAWERLVRSVKVAMGAVSE--S---S-RKP----DDETF----- --ETI-----LTEAEAMINSRP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >503/1-545 ---CTKRQVLSDVAHIFDPLGILAPVVVQFKILLQE-LWLL-D----------L------ -DWDS-E-LPM--KQAHSWQMYRKDISSL----Q-LKIP--RFI--D------------- --SHMD-----HI-ELHA-FSDASLK-AYS-AVVYSR--VEYS-DG------SIGV-Y-- LVAA---------------------------KTRV-APL-------K------------- ---L----------------------------ATLPRLELCGAL-LLT-RLVKAIQAS-- -L-G----K-K-E---VKV---YA---------WC------------------------- ------------------------------DATSKKVFYMPHHPV-------L------G AKL-RVVFDGSFQDQ-DX---RSLNDALHIXPCIQ--RNLFNVCMRFR---MHKF--XFS ADIVKMFRQILVAPK--HQDFQR-----I------LWREH---P-SA---------PL-K HFRLCTVTYGTASAPFLAVRV-LEQL------------A----KDH-EHEF--P-RAAKI L-LXD--FYVDDV-LTGAM-T---EEEXIXXQXXLX-XL-MSRA-------QLELG-KWI SNST-RL-XTAQGDRV------NMST---------------------------------- --ATS-----------------KV--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------RQ AFTFEHTGVDYAGPIL-------------------------------------------- ----------------------------LKVH--KGRN---PRKE-----KG-YIC---L -FVCMV--TSALHLELATDLSTDTF-----LAALRRF-MARR-GKPAEMYSDNGRNFVGA KRTLN-E-------MSQLHTSR-EH------------------NEVVA---RKLAEQSIK ----WNFIPPYTPHWGGKWESAVRSVKLHLRRVIG--N-----TVI----TFEQM----- --RTL-----LTQIEAVVNSRP--------LCA------------T-------------- ----------------------SD--------TE-----------I-------------- ----------- >504/1-534 ---PSKREVLKVVMSLFDPLGFISFFLVHGKILIQD-IWSR-G----------T------ -EWDE-S-IAQ--DLYTRWRQWTGLFSELD---S-VRIP--RCY--F------------- -RHPFPK-NLDNL-QVHV-FVDASEA-AYS-CVAYFR--LEY--EG------VVQV-A-- FVSS---------------------------KTKV-APL--K-T---------------- --------------------------------ISIPRLELKAAV-LGT-RMLNSIKKQ-- -H------S-YPI---ARQ---FM---------WS------------------------- -------------------------------------WYLPLGIV-------TNPK-K-P GKV-RLIWDAAAK-V-GG---VSFNSKLLKGPDLL--TPLPQVLCHFR---QFPV--AVC GDIMEMFHQIKIRFP--DCQSQR-----F------VYRNK---P-TD---------H-PQ IYVMDVATFGSKSSPASAQYV-KNLN------------A----KEF-EEEF--P-RAALA I-ENS--HYVDDY-LDSFQ-S---INEAIEVVNEVK-LV-HSRG-------GFTLR-HFL SNEA-DV-LQGV--GEF----EEEM-AKHLAL-----------------------E-R-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF VRPFTFVGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NA-----KR-WVA---L -FTCLT--TRAVHMEVVHSLSTESC-----IMAVRRF-VSRR-GPPREFWTDNATCFQGA NNELK-A-E------IEA-KTK-A----------------------LA---LTFTSAQTS ----WNFIPPATPHMGGAWERLVRSVKVAIGAILD--A---P-RKP----DDETL----- --ETI-----LYEAEAMVNSRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >505/1-562 ---TTKRIIYSEVAKLFDPLGLFAPTIVLAKLLVQQ-LWRT-Q----------K------ -GWDD-P-LDD--DTEQQWIRLKQSLPLLK---D-FPIP--RQV--T------------- --VN-E-AV--RF-ELHG-FADASNV-AFG-ACIYIR--SIQS-DG------SAIS-R-- LLTS---------------------------KSKV-APL-------R------------- ---D----------------------------VSIPRKELCAAL-LLA-RLLERVLVA-- -I-P----T-K-F---HRV---IL---------WS------------------------- ---------------------------------------LPHHAV-------LRPS-SST TKC-RVVFDASAKSAEDH---LSLNEVLLVGPVVQ--SELYDILLRAR---MRRY--VFS ADISKMYRQIRMHHD--DSRFLR-----I------FWRDD---P-TK---------PL-R VLELTTVTYGTASAPFQATRC-LNQL------------A----EDE-RQDF--P-MAAEI V-TND--CYVDDI-LSGTD-T---LEEAIDAQRQLK-GM-LAKG-------GFPIH-KWC SNSP-EL-LDRIPEAEREQTK------NIE---------------------------DND INQVI-----------------KI--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TP SPPFSVTGVDYAGPML-------------------------------------------- ----------------------------IK--QGSYRP---KVV------KA-YIA---V -FVCMS--TKAVHLELVSDLTTDAF-----IAALQRF-VSRR-GIVSEMHSDNATNFRGA QHELH-H-------LYELFQKE-HE------------------VNRII---RYCQSKEME ----WQFIPPDAPEFGGLWEAAVKSTKNHLKRVIG--N-----VKL----TFEEM----- --VTV-----LCEIEAILNSRP--------LFT------------V-------------- ----------------------YN--------DPA--D-------PEVITPSHY------ ----------- >506/1-607 ---PTKRIVLSAVGQLFDPCGYLGPVITMAKMLMQD-LWRL-K----------L------ -EWDD-V-LPD--EQMKMWNDFRGQLPMVN---N-LQKK--RCV--V------------- --TG-D-AK--GV-ELHG-FADASLR-AYG-AVLYTR--CISP-DG------TVEV-N-- LVCS---------------------------KSRV-APL-------K------------- ---P----------------------------MTIPRLELCGAL-LLA-RLVDKTISA-- -M-K----I-P-F---KSV---TL---------HL------------------------- ------------------------------DF-----YFLPHHAV-------YKES-STT TKI-RVVFDASAKTT-SG---HSLNDALDVGPTVQ--KDLITILLRFC---CFPV--VLT ADIPKMYRQVQIHED--DRKYQR-----I------LWLNS---K-NE----------I-G TFELTTVTYGCSSAPYLATRA-LMQL------------A----KDE-ASEL--P-VAARV I-EEN--SYIDDF-LTGGN-T---DEEVIEIYEQLT-EM-LRRG-------GFGVH-KFC TNSE-II-RNRIPTELQEMQA------NFE---------------------------DSD INSAI-----------------KT--LG-------------------------------- -----LIWNQHEDYFRFNVAPLDETVPTKRIVLSAVGQLFDPCGYLGPVI---------- -------------------------------------------------MGNLPNYRITP APVFSNTGVDYAGPIY-------------------------------------------- ----------------------------LK--EAGRKT---VVY------KA-YIC---V -FVCMA--TKAIHLEVVSNLTAGNF-----IAALQRF-ISRR-GIVANLYSDNGTTFVGA NHELA-A-------LRQLFEDQ-AT------------------QRKLN---DFCVSKGIQ ----WHFIPPRSPHFGGIWEAGVKSAKYHLKRVVG--E-----TKL----TFEEM----- --STF-----LTQCEAILNSRP--------LIP------------I-------------- ----------------------SN--------DPN--D-------V-------------- ----------- >507/1-604 ---PTKRQMLRCLMGIYDPLGLLGVFIVHGKILLQD-VWRT-G----------L------ -QWDE-T-VPD--EIFERWIRWTSLFPKIG---D-LRIP--RCY--F------------- -KAATDK-MYERL-QLHV-FVDASEA-AFS-AVAYFR--VTNK-ES------YSEC-T-- LVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-LGS-RLMSFVQES-- -H------S-IEV---KQR---YL---------WS------------------------- ---------------Q---------------ADPKRVWYLPLGVV-------TNPR-K-P GKV-RLIWDAAAK-V-DG---ISLNSMLLKGPDQL--TSLPAVLSRFR---QFKV--GVS ADIREMFHQLRIRES--DRHSQR-----F------LFRSD---P-MK---------P-IE TYLMDVATFGSTCSPASAQYV-KNKN------------A----EEF-SELF--P-RAVEG I-LEN--HYVDDY-LDSFG-N---EEEAERVSSEIR-SI-HQSG-------GFQLR-NWL SNSA-VV-LRGL--NEV----DPRA-SKNLCW-----------------------N-TND SS--D-----------------RV--LG-------------------------------- -----MLWQTADDELRFSMKLKEEVQQVIDSGKRPTKRQMLRCLMGIYDPLGLLGVFI-- ----------------------------------------------------------AF VRPFTYTGIDFFGPLL-------------------------------------------- ----------------------------VK--VG-R-----S-SA-----KR-WIC---L -FTCLT--TRAVHVEVAYSLSTPSC-----VKCVRRF-VCRR-GAPAEIYTDNGTNFLGA ERLLR-E-Q------LKT-LHS-D----------------------LA---ATFTNADTK ----WSFIPPGAPHMGGAWERMVRSIKSAMETAYN--S---D-RKL----DDEGL----- --ETL-----VVEAEGIVNSRP--------LTY------------L-------------- ----------------------PL-------------DA--------------------- ----------- >509/1-544 ---YTKRSVLSQIAKLFDPAGWLAPFVIRAKIFMQA-LWLR-G----------L------ -DWDQ-P-LPG--DLLTQWQEFILSFSSLR---D-IRVP--RWV--H------------- -FQPRA-----TI-XFHG-FCDASER-AYG-XAVYLR--VELG-NQ------I-FV-N-- LLSA---------------------------KTRV-API-------K------------- ---S----------------------------LSIPRLELCGAV-LLT-DLCSVLLPA-- -S------P-AVS---FQS---LY---------WT------------------------- -------------------------------------FYLPHHAV-------FKPD-STT TKV-RVVFNASCPSS-NE---KSLNDILHPGPVLQ--SDLTMQILQWR---YYRY--VFN ADITKMYRQIRVDPK--HTPFQR-----I------LFR-K---P-DG---------NI-G DFELSTVTFGVNCAPFLALRV-LKQL------------A----NDV-RFRL--P-LASKV I-SEC--MYVDGV-LAGAH-S---KEKVIATIAELT-DA-LQSA-------GFPLR-KWT SNSM-DC-LKAIPKSHRLCED----FLELE------------------------------ DSSTA-----------------KT--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------IF TRPFTVVGVDFAGPFD-------------------------------------------- ----------------------------VKNY--AGRA---CLIT-----KG-YVC---V -FVCFS--TKAIHLEATSDLTTEKF-----LAAFSRL-VARR-GCPQKIYSDNGKTFVGA AKTLSRD-------FVESL------------------------RSEVL---AKHTLHNLS ----CHFNPPSAPHMGGLWESGVKSFKALFYKSTA--M-----TKY----TFEEL----- --STL-----LARIEACLNSRP--------IAP------------M-------------- ----------------------SE------------------------------------ ----------- >51/1-542 ----TKREVLSQIAKLFDPAGWLAPVIVRAKIFMQE-IWLQ-E----------L------ -GWDD-S-LPE--DLVQRWHDFLTDYPSLE---E-IRIP--RWV--D------------- -FQQKA-----KV-QFHG-FCDASQR-AYG-AALYLR--VEIN-GC------I-ST-H-- LLAA---------------------------KTRV-APV-------K------------- ---T----------------------------VSLPRLELCGAV-LLS-ELTTALIPQ-- -L------P--IQ---SEN---FN---------WT------------------------- -------------------------------------FYLPHHAV-------FKPD-STT TKV-RVVFNASSPSS-NG---KSLNDSLHTGLVLQ--SDLTIQILKWR---FYRY--VFN ADITKMYRQIQVDPR--HTPYQR-----I------LFR-N---E-NE---------EL-C DFELNTVTFGSNCAPYLAIRV-LDQL------------A----RDI-REQC--P-IASDI I-ENY--MYVDDV-LAGAH-T---KQ-AISAIAELR-MA-LDRS-------GFPLR-KWC SNTK-EVCLKGIRRDHLLCAD----FL--E------------------------------ EAPVA-----------------KT--LG-------------------------------- -----RLGT--------------------------------------------------- ----------------------------------------------------------TF SRPHTHTGVDFAGPFD-------------------------------------------- ----------------------------IKSY--IGRA---CKIT-----KG-YVC---V -FVCFS--TKAIHLEATTDLTTERF-----LAAFSRF-IARR-GLPQQMYSDNGKTFVGA SSVLSRD-------FLQAT------------------------KELIL---SKHSHQNLC ----WHFNPPGASHMGGLWEAGVKSFKTHFYKSTS--S-----TKY----TFEEF----- --ATL-----LSKIEACLNSRP--------ISP------------M-------------- ----------------------SE---------------------L-------------- ----------- >510/1-554 ---PTKREMLKVVMSLFDPLGLVTFFLIHGRILIQD-AWAT-G----------I------ -GWDA-P-IDG--PLLHKWRLWISGFILLN---S-LRIP--RSY--F------------- -RHTVT----SPV-QLHV-FVDASTE-AYA-CVAYFS--AIG--PA------GIEV-A-- LVAA---------------------------RGKV-API--K-V---------------- --------------------------------LSVPRLELNAAV-LGT-RLAESVINS-- -H------T-YQI---ERK---YF---------WS------------------------- -------------------------------------WYLPLSIV-------INPR-K-P DKI-RLVWDAAAQ-V-HG---VSFNSALLKGPDLL--TPLVAVLSHFR---EHKF--AVS GDIKEMFLRMLIRAE--DRHAQR-----F------LWRTD---P-DE---------T-PH IYIIDVATFGSTCSPSSAQFV-KNLN------------A----QDY-MQQF--P-RAAIA I-IKF--HYVDDY-LDSFA-T---VDEAIEVVKDVK-YI-HSKG-------GFEIR-NFL SNSE-KL-LEAI--QED----PRQK-EKDLNI-----------------------T-RAE KV--E-----------------SV--LG-------------------------------- -----MKWNPKTDVFSYAL----------------------------------------- ----------------------------------------------------------PF IKPFTYVGVDYFGPLL-------------------------------------------- ----------------------------VK--VG-R-----T-QS-----KR-WVA---L -FTCLT--VRAIHLEVVNSLSSESC-----IMAVRRF-IARR-GAPAEIFSDNGTCFVGA NKQLQ-Q-E------IQT-INN-D----------------------LA---GTFTNTNTR ----WCFNPPNAPHMGGVWERLVRSVKQAIGTIIE--A---P-RLP----DDETL----- --ATI-----LADAESMINSRP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >511/1-529 ---PTKRQMLKCLMGIFDPLGLLSVFLVHGKILLQD-VWRT-G----------L------ -QWDE-K-VPE--RIFERWIRWISLFPEIG---N-LRIP--RCY--F------------- -KGASAQ-MYGRL-QLHI-FVDASEA-AFS-AVAYFR--VVNA-EG------NPEC-S-- IVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-LGS-RLMSFVQKS-- -H------R-IEV---KQR---FM---------WS------------------------- ---------------Q---------------ADPKRVWYLPLGAV-------TNPR-K-P GKV-RLIWDAAAK-V-DG---ISLNSMLLKGPDQL--TSLPAVLSRFR---QYPV--GVS ADIKEMFHQLLIRPA--DRHSQR-----F------VFRNN---P-AD---------P-VD IYLMDVATFGSTCSPASAQFV-KNQN------------A----EAF-VNIF--P-RAVEG I-VDN--HYVDDY-LDSFE-N---EDEAERVSREVR-SI-HQKG-------GFLLR-NWL SNST-IV-LRGL--NE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SY SRPFTYTGIDFFGPLL-------------------------------------------- ----------------------------VK--VG-R-----S-AA-----KR-WIC---I -FTCLT--IRAVHVEVAHSLSTSSC-----MSCIRRF-VCRR-GAPAEIYTDNGTNFQGA ERLLK-E-Q------LLK-MHD-E----------------------LA---ATYTNTDTK ----WIFIPPGAPHMGGAWERMVRSIKSAMETAYN--S---D-RKL----DDEGL----- --ATL-----VVEAEGIVNSRP--------LTY------------L-------------- ----------------------PL-------------DA--------------------- ----------- >512/1-523 ---PTRKEILSMVSQIYDPVGFVQPFVLPIKKVLQG-KXID-G----------L------ -GWDE-T-LST--ALRQTWTKWLNDLPNLE---Q-VTIP--RCF---------------- --KSRTTKIKPQS-ELHC-FSDASES-GCG-AVCYLRYRENDTWNS-----------T-- FVMG---------------------------KSRV-SSS--K-P---------------- --------------------------------VAIPRLELTAAV-ASV-KLKRDCYEG-- --------TGMQH---FKS---HI---------LD------------------------- ---------------I-----------------CDRTWYIPHHCT-------G------- KKF-RIVFDCAAT-F-NG---TSLNDALLQGPDLT--NSLVGVLLRFR---QEPI--AFI ADIKSMFYQVHVKPT--DWNALR-----F------LWWPA---GDLS---------KPPE DYQMLVHLFGATSSPSCASFA-LQKV------------A----EDN-EIGA--SETTLST I-RRS--FYVDDC-LKSVQ-T---KDEAVQLIKELT-AL-LKCG-------GFHLT-KFV SNKR-EV-LQH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG QHPFTSVGVDYMGPXI-------------------------------------------- ----------------------------VK--IG-R-----S-QV-----KR-FGC---I -FTCMA--TRAVHIEVAHSLDTSSF-----LHAFRRF-INRR-GRPKVIRSDNGTNFVGA ERELR-E-------GLQRLNKD-Q----------------------IS---NSMMNEEIX ----WYFNPPAASHQGGIWERIIRSVRKILRYLTC--E---R--TM----TDEQL----- --STF-----MTEVERILNDRP--------LTP------------V-------------- ----------------------ST-------------NPQD--------L---------- ----------- >513/1-557 ---PTKRIVLSCVMGFFDPLGLLAPFTVHGKILVQE-LWRT-G----------C------ -DWDE-K-IEG--ECLESWKRWMSLLSAVE---A-LRIP--RRY--F------------- -GDLYSS-SLRSI-ELHI-FTDASEC-AYG-AVAYFR--VAVG-DH-------VRC-S-- LVMA---------------------------RSKV-APL--K-Q---------------- --------------------------------QSIPRLELMAAV-LGA-KLLTTVKTN-- -H------S-LTV---HRQ---YL---------WT------------------------- -----------------------------------KVWYIPLDVV-------VNPL-K-- GKV-RLVWDGRAS-A-NG---VSLNSQLMKGPDML--ASLPAVINRFR---ERRI--GFG GDIKEMYHQIRIREE--DKQAQR-----F------LFRAA---E-SE---------P-PK VYVMDVATFGSTCSPCSAQFV-KNKN------------A----MEY-AVEY--P-EAAEA I-VKK--HYVDDY-YDSVD-T---EEEAIRRASEVK-LV-HSKG-------GFEIR-NWV SNSA-QV-LRSL--GE-----QKVDQAVHFNQ-----------------------D-KES GS--E-----------------RV--LG-------------------------------- -----IIW---------------------------------------------------- ----------------------------------------------------------PS LRPFSAVGVDYLGPVT-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WVA---L -FTCLA--VRAVHLEVVHSLSTQSC-----LMAIRRF-VCKR-GMPQEFFSDNGTNFVGA SKEIG-R-S------VKQ-VDE-E----------------------CA---EAVMCSTTK ----WNFNPPGTPHMGGIWERMVRSVKEALKA-FD--D---G-RKL----TDEVL----- --QTT-----LAEAEDMINTRP--------LTY------------M----SQESDEQEAI T---------------------PN-------------HF--------------------- ----------- >514/1-563 ---PTKRSMLSQIASIFDPLGLLAPIIVKAKLIMQQ-LWEL-R----------V------ -DWDE-T-LPG--EFVQNWSSFVQNLSDLQ---Y-LQVP--RRV--I------------- --GIRG-AS--RI-CLHG-YSDASER-AMG-ACVYIR--AADK-HG------NTSS-H-- LLCA---------------------------KSKI-API--G-NGR-------------- --------------------------------TTLPRLELCAAV-ILS-RLMTNVISA-- -I-S----L-PI----NEI---LA---------FS------------------------- --------------------------------APKGAVYLPHHCV-------MKEA-SST TKC-RVVFDASAKTT-SG---KSLNDVLMAGPVLQ--DSIVNILLRFR---FPAI--VVT GDIKQMYRMVDVHEA--DRDFQR-----I------LWRWS---D-NE---------PI-C EYRLNTVTYGTKSASYLSTKC-VQQL------------L----HSY-KEQY--P-TAVEK A-EKG--TYVDDV-LTGAD-S---EEEAVLLRQQLT-TI-FAAG-------GFHLR-KWA SNSS-EV-LNGVPAEDREVKL------PIE----------------------------LN NSRTI-----------------KA--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------KP NPPFSITGIDYAGPIN-------------------------------------------- ----------------------------IISR--RVRG---ATPS-----KG-YIA---L -FVCFT--TRAVHLEAVSDLSTSAF-----IAAFIRF-SSRY-GLPSKVYSDNATNLRGA ARKFR-E-------LYKRINTT-ID------------------ADVFI---DFLSNKGIE ----WVFIPARSPHHGGLWEAGIKVAKGFLSKFGX--E-----TRF----TFEEL----- --STI-----LAQVAACMNSRP--------IAA------------L-------------- ----------------------SD--------DPN--E-------P-------------- ----------- >515/1-521 ----TKRSILRFVMSVFDPLGLISNLLVHGKVIIQD-LWRA-K----------V------ -GWDE-D-IPE--EVFEDWKRWIEQLSQLS---G-TRIP--RCY--F------------- -PGYEPD-SFKSL-QLHV-FADASET-AYA-CVAYFR--IID--RG------QPRC-A-- LIAS---------------------------KAKV-APL--K-P---------------- --------------------------------LSIPKLELQAAI-IGS-RLAKSIAEY-- -H------T-IPV---SRR---FF---------WC------------------------- -------------------------------------WYLPLGVV-------TNPR-K-P GKV-RIIWDAAAK-V-NG---VSLNDMLLKGPDLL--RSLPAVLCRFR---QRQV--AIA GDIREMYHQLKIRKE--DRQAQR-----F------LYRSD---P-LK---------K-PE VFVMDVATFGSTCSPCSANFV-KNYN------------A----EEW-KEEL--P-EAAEA V-VEN--HYVDDY-LDSRD-T---EEEMTKLASKVR-RV-QDAA-------GFELR-NWR SNSE-KV-LQTL--GE-G------------------------------------------ ------------------------------------------------------------ -------A---------------------------------------------------- ----------------------------------------------------------PF VRPFSLVGIDYFGPYA-------------------------------------------- ----------------------------IK--IG-R-----S-QV-----KR-WVA---L -FTCLV--IRAVHLEVVTSLSTESC-----KLALRRF-IARR-GAPTKIYTDHGTNFVGA SRELA-T-Q------LAA-MNK-E----------------------LA---ETFTDTNTR ----WYFIPPSSPHMGGAWERMVRAVKVAMTS-IN--N---S-RTP----SEEVL----- --QTV-----LCDAESMVNSRP--------LTY------------V-------------- ----------------------PL-------------ET--------------------- ----------- >516/1-521 ----TKRTILQFVASQYDPLGFLVPIMVRFKIFLQN-LWK-KN----------N------ -SWDQ-I-LDE--QDHKQWKFLIAEWAT-V---V-KDLP--RFV--T------------- ----T---STDLI-GIHV-FTDASSV-AYS-AAVYLV--SQDMKE--------TKS-S-- LIFA---------------------------KSRI-API--K-------G---------- --------------------------------MTIPRLELMAIL-IGT-RAAQFVMTQ-- -L------D-IVNT---RI---IL---------WS------------------------- --------------------------------------------------------GKTT TKL-RIVYDALAHIK-GM---KSLNEVLYRGSINL--PDLVGVLLRFR---MMKG--VIT ADIEKAFLQIQLHPS--ERNCTR-----F------LWLKE---V-EG----SVSNENI-K CYRFRRIPFGVISSPFLLSAT-LNYH------------L------ENHVS---E-LA-AE I-KKN--LYVDNV-IVSSN-G---TQDALEKYAEMK-SI-FNEA-------SMNLR-EFL SNDE-EF-YAELPQQDR--A---------------------------------------- IRKNT-----------------KI--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------NR SRAFARVGVDYFGPLS-------------------------------------------- ----------------------------IKS--NSVST------------KR-WVI---L -FTCFT--TRAMHLELAEDQSAEIF-----LHAIRRF-VARR-GCPELILSDNATQFQA- FRSLM-T--------------Q--V---KV-----------------S---NFLAKGGMT ----WKNIIPKAPWQGGIYERLIGLTKNALRRAIG--R-----KFL----AEREL----- --VTL-----IAEVEGILNTRP--------LTY------------A-------------- ----------------------NF--------D-D--C-------VIIR----------- ----------- >518/1-540 ---PTKQNVASRLAETFDPLGYTIPILVXCKRLMQK-CW-VDN----------M------ -RWKE-K-IPQ--KLLVDWYKVKEGLQDKE-----LTIP--RQL---------------- ---T-VNYDYRSL-RLMV-FSDASQD-MMA-ATVYAH--YSY-EDA------PPVV-Q-- LLAA---------------------------KNKI-KSAKNE-K---------------- --------------------------------WTIPKLELFAIE-IGT-NMAVTTVHE-- -I------R---IPI-TEV---CF---------FT------------------------- ---------------------------------------IPHRVV-------VKM-SSLT TKL-RIVYDASSKKK-DT---LSLNQCVHPGPSML--QSIYGILVRAR---MYKY--IVI ADIEKAFHQVQMQPQ--FRDLTR-----F------LWLKD---I-TK----PVTRENT-E TLHFRKIPFGLTASPFLLAAT-IVHF------------L-------LKNPH--S-LN-EM T-RDN--LYVDNC-LYHTN-D---REEIPRLVKSAK-EI-FNLM-------PMNLR-EFI VNDS-IE-MGKIPEKDR--A---------------------------------------- SALEI-----------------KV--LG-------------------------------- -----YLW---------------------------------------------------- ----------------------------------------------------------EP SVPFAHSGLDYMGPIP-------------------------------------------- ----------------------------YTKDDG-AIG------------KA-YVL---I -YTCLV--TRGARLELVPDGTTERY-----IESLGII-FSRS-GFPESVYSDNARTFQLG EKIIN-D-------DVDC----------GE-V-----------SESLT---SYLATHQID ----FQYITPLAPWQGGIYERVVKLVKNQLQKVLG--D-----NTL----DFHSL----- --RRV-----LAGAEAMVNSRP--------LVA------------H-------------- ----------------------PK--------R------------L-------------- ----------- >519/1-546 -----KRDILSTIAKIFDPLGLIGPAIIPAKAFMQE-LWQL-Q----------I------ -DWSD-P-LPE--SMKQRWQNYVENLHDVE---S-IKIP--RRC--M------------- --NIDH-PM--RL-LLHG-YCDASNI-AYG-AVLYLR--AIDK-AG------NVSS-R-- LLCS---------------------------KSKV-VPI--N-R---------------- --------------------------------PTIPRLELCAAV-LLA-RLIDTVKAA-- -L-R----I---P---IHQT--VA---------WS------------------------- ------------------------------ASPPDRIIYLPHHGV-------LKEQ-STT TKL-RVVFNASAKSS-NG---VSLNDLLMVGPVVQ--TNLYAILLNFR---TPKI--AIT GDIERMYLQINVSDA--DRHRIR-----M------LWQ-E---R-DQ---------HL-A EYTLNTVTFGMACAPFLATRT-LKQL------------G----DDD-GHLY--P-LAQEA M--ED--FYVDDC-LTGAS-S---IEEAIEKRRQIT-EL-LQRG-------GFSIR-KWA TNEP-AV-LHDIPPPDRAV----------------------------------------- -----------------------S--LS-------------------------------- -----QEL---------------------------------------------------- ----------------------------------------------------------QP VPPFYISGVDYGGPIT-------------------------------------------- ----------------------------LVQR--RGPG---SPTT-----KG-YIA---M -FVCFV--TRAVHIEAVSKLSSKAF-----LAALRRF-VARR-GHCGHLYSDNGTNFVGA AKEMI-Q-------WYRTIQSP-DH------------------NNSVA---DMLARGGTQ ----WHFIPPGSPHLGGLWEAAIKSAKHHLNIVTR--N-----VRL----TFEEF----- --STL-----LTEIEGILNSRP--------ISP------------A-------------- ----------------------SS--------DPN--D-------V-------------- ----------- >520/1-549 ---PTKRIVLSSVMGFFDPLGLLTPFTIHGKLVVQE-LWRT-G----------C------ -DWDE-E-IDD--DSLAKWDRWTGLLPIVS---E-IRIP--RCY--F------------- -EGSLST-SFECL-ELHV-FTDASIH-AYG-CAAYFR--AVIG-GS-------IKC-S-- LVMS---------------------------RSKV-SPL--K-L---------------- --------------------------------QSVPRLELMAAV-LGA-RMMHTVKSN-- -H------S-LPI---TRQ---IL---------WS------------------------- -------------------------------------WFLPINVV-------LNAK-K-P GKV-RLVWDAAAT-V-NG---VSLNSQLLTGPDLL--TPLPSVINRFR---ERPI--GFG GDIREMYHQILIREA--DKRAQL-----F------VFRNT---P-DQ---------H-PS VYVMDVATFGSKCSPSQAQYV-KNRN------------A----SEF-SKQF--P-EAADA I-EKK--HYVDDY-FDSVD-T---VEEAIDRAKEVR-FI-HSKG-------GFEIR-NWV SNSG-TF-LDEL--GE-----EKASQAVHLNR-----------------------D-KDS GT--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PQ LRPFCSVGVDYLGPVE-------------------------------------------- ----------------------------VS--VG-R-----R-KE-----KR-WIA---L -FTCLA--VRAIHLDVVHSLTTEAC-----QMAIRRF-ICRR-GSPDEFFSDNGTNFKGA SNEMT-R-A------IEE-IKT-E----------------------CA---ESFVSPAIK ----WHFIPPSTPHMGGVWERMVKSVKAALKA-IN--D---G-RKL----TDEVL----- --LTT-----LSEAEDMINTRP--------LTY------------L----SQES------ ----------------------GV-------------EA--------------------- ----------- >522/1-601 ---CTRRGMLSVSSSVYDPLGFLAPILLPAKIMLQE-LCRR-N----------Y------ -GWDE-T-VPQ--ELLHRWTRWIEELEMLS---N-FEIN--RCI--K------------- -PKDFGT--AIHA-QLHH-FSDASEL-GYG-AVTYLR--IQNS-KN------VIHV-A-- FVMG---------------------------KARV-TPL--K-T---------------- --------------------------------VTIPRLELTAAV-LAV-RMDLMLKKE-- -L------Q-IPL---AES---IF---------WT------------------------- ---------------S---------------GSSGKVWYIPHHGI-------YHPR-K-- KSL-RVVFDCSAS-F-KG---SSLNEQLLQGPNFN--STLIGVLLRFR---QEPV--AFM GDVQAMYYQVKVPEE--DRDLLR-----F------LWWPE---GDLT---------KDAS EFRMTVHLFGAVSSPSCAIFA-LRKT------------A----DDN-QAEF--PAEIPQT V-KEN--FYVDDC-LKSVE-S---EKKAVTMIKHLT-TL-CQKG-------GFTLT-KWV SNSC-YV-LQAM-------PQEYRAKGVEELD-----------------------MDRDE -LPME-----------------RA--LG-------------------------------- -----LQWCVQKDTFTFKMAPCQRSCTRRGMLSVSSSVYDPLGFLAPIL----------- ----------------------------------------------------------PD KPPFTNTGVDYFGPIE-------------------------------------------- ----------------------------VK--KG-R-----G-TA-----KR-YGV---I -FTCLS--SRAVHLEIANSLNTDAC-----INAIRRF-VCRR-GQVVNLLSDNGTNFKGA EKELR-E-------ALLTLNQT-N----------------------IG---GMLQQKGIK ----WSFNPPSASHYGGVWERMIRMVRRILSSVLH--Q---Q--KL----DDDGL----- --HTV-----ICEVEAILNDRP--------ITK------------L-------------- ----------------------SD-------------D--------PNDL---------- ----------- >524/1-563 ---WTKRRILSAIAKLFDPLGLISPVVVTAKIMMQE-IAVL-K----------T------ -GWDA-P-VPA--PLERKWKLFHSSLSKLA---E-FSIS--RFA--F------------- --VG-D-YV--DV-QLHC-FADASEV-AYG-ACIYVR--SVDR-HG------TARI-E-- LLSA---------------------------KSRV-APL-------Q------------- ---R----------------------------MTIPRLELCAAR-EAA-HLYQTVTKA-- -L-A----L-N-G---IEA---YF---------WS------------------------- ------------------------------GIHQRKAFYLPHHAV-------LKES-STT TKV-RVVFDASARSD-TG---YSLNDVLLKGPVIQ--EELLNLLIRFR---KHEV--ALV GDVAKMYRQVLHDAN--DALRLR-----I------FFRFE---K-DE---------PV-D VYELLTVTYGLKPSSFLATRA-LQQL------------A----VDE-GSEN--S-PASTA L-KND--FYVDDY-IGGAA-N---VDEAIGLRKDLT-SL-MAKG-------GFPIR-KWC SNRP-EV-LAGIPEDQLGTNL--T-I-KFD-------------------------LSP-- -EERV-----------------KT--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------RP ARAFIKTGVDYCGPFF-------------------------------------------- ----------------------------LKPP--HRRA---APP------KV-YIA---V -FICFT--TKAIHLELVMDLSSAGF-----ISALRRF-IGTH-GIPSEIHSDNATNFQGA KHELH-E-------LYKSLNSK-TG------------------QQTIG---SELAHQGIS ----WHFIPPRAPNFGGLWEAAVRSAKTALKKDIG--A-----NQL----THENF----- --CTL-----LVQIAAALNSRP--------LSP------------L-------------- ----------------------SD--------DPV--D-------M-------------- ----------- >525/1-542 -----KRSVLSQLTRIFDPLGWLTPVTLQGKCFMXE-LWKM-S----------F------ -KWDA-E-LEK--GLADIWRNFANELPALT---S-IRIP--RWI--G------------- --SKGL-----TAIELHG-FCDASEK-AYA-AVVYAK--I------------GSQV-T-- LLAS---------------------------RSKV-NPL-------K------------- ---NK---------------------------KTIPKLELCAAQ-LLA-KLLFRISST-- -M------N-C-R---GQI---NA---------WS------------------------- ------------------------------------KYYLPHQAV-------IKQD-SLT TKL-RVVFDASAKAT-CG---RSLNDAMSIGPKIQ--RDIFDILSSWR---MWRY--VMT ADVEKMYRQIKITPI--DQEYQY-----I------VWREN---Q-KE---------SI-K EFKLTTVTYGTSAAPYLAVRS-LHHL------------A----DLY-CKDD--E-KLTHI I-KKD--FYMDDL-MTGAN-T---IEDCTAIQQKIR-AV-LNKG-------GMHLR-KWV SNDK-KI-IASITNTNKSEKI------------------------------------AIT KDETI-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------IG EFPFYATGIDYPGPFX-------------------------------------------- ----------------------------IRCS--KGRG---QKAY-----KG-YVC---I -FICMA--TKAIHLELVSDMTTEKF-----LETLHRF-FARR-GKSKHLYSDNGTNFVGA ARKLN-V-------DLEAAILS-NT--------------------KLA---PILQKDGIT ----WHFIPPGSPHMGGLWEAGVKSMKYHLKRILG--N-----NSC----TYEEI----- --STL-----LCRIEAVLNSRP--------LIS------------M-------------- ----------------------EN--------ES-------------------------- ----------- >526/1-556 ---PTKRNILRCVMSQYDPLGLLSHFLIHGRVIIQD-IWRT-K----------A------ -AWDD-T-VGE--EIQERWKRWTELFEDLK---K-VRLP--RAY--F------------- -PGVVSS-EIEDL-QLHI-FVDASET-AYA-CVAYFR--AKI--RG------KFHT-A-- LVGA---------------------------KSKV-SPL--K-S---------------- --------------------------------LSVPRLELQAAI-IGC-RLLKSLCAS-- -H------S-LPI---KRR---FI---------WT------------------------- -------------------------------------WYLPLSVV-------QNPK-K-P SKI-RLVWDAAAK-V-NG---ISLNSMLMKGPDLV--VPLPTVLYGFR---ERQV--ALG GDLQEMFHQVKIRFE--DRQAQR-----F------LYRET---P-TE---------K-PT VFIMDVATFGSTSSPCSAQYI-KNLN------------A----REH-AVEY--P-RGAEA I-ERR--HYVDDY-LDSFD-D---EDEACRVAEEVR-TI-HSRG-------GFTIR-NWL SNSS-EV-LRRV--GA-TSDC----RQMVVGA-----------------------D-KXS QT--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------PF VRPFSYVGLDYFGPIQ-------------------------------------------- ----------------------------VK--VG-R-----S-LV-----KR-WVA---L -FTCLT--IRAVHLEVAHSLSTNSC-----KMAIRRF-LVRR-GSPLEIWSDNGTNFLGA SRELQ-E-Q------MNQ-MNE-K----------------------LS---AVFTNATTK ----WVFNPPSAPHMGGSWERLVRSVKVAFTA-LS--I---T-RNP----DDETL----- --LTL-----MVEAEGVVNTRP--------LTF------------M-------------- ----------------------PL-------------ENDSQEALTPNHF---------- ----------- >527/1-560 ---PTKRSILSDIAKLFDPLGLISPVVVRAKILMQE-LWLL-S----------C------ -DWDE-P-VPE--PVKSKWENYHQELSTIS---E-HRVD--RYA--F------------- --LP-D-SK---I-QLHT-FADASQN-AYG-ACTYAR--CEDN-QG------RIRI-Q-- LLAS---------------------------KSSV-APL-------K------------- ---R----------------------------ITIARLELCAAV-VAA-HLHDRIKKA-- -T-D----I-E-I---SAS---YF---------WS------------------------- ------------------------------DEERSRTYYLPHHAV-------IKEA-STT TKV-RVVFDGSAKTS-TG---FSLNEALCVGPVVQ--DELIDIILRFR---TFPV--ALV GDIAKMYRQVLIHPD--DTPLQR-----I------LWRFT---Q-LS---------PV-Q TYELLTVTYGLAPSSFLATRT-LKQL------------A----DDE-GEPF--A-KGAPA L-KKG--FYVDDF-IGGAQ-S---VKEAILLRDELS-EL-LKKG-------GFELR-KWT SNRL-EV-LQGLNDEQIGTKS--S-L-EFK---------------------------P-- -HETI-----------------KA--LG-------------------------------- -----INW---------------------------------------------------- ----------------------------------------------------------IP SRPFSVTGIDYAGPLY-------------------------------------------- ----------------------------LRPI--HKRA---SPA------KA-YLC---L -FVCFS--TKAVHLELVGDLSTQAF-----LCSLRRF-ISRR-GRPAHIHSDNGKNFEGA KNELA-E-------LFARFQDQ-SQ------------------HNEIA---TFCSDEGIT ----WHLTPPKAPHFGGLWEAAVKVAKKHLFRQLG--S-----SRL----SFEDM----- --CTV-----LTQIEAIMNSRP--------LLP------------I-------------- ----------------------TE--------DPN--D-------L-------------- ----------- >528/1-573 ---PTKRKVLSDISKFFDPCGLAAPVVMTGKIYMQD-LWRG-K----------K------ -KWDV-A-LKE--DLAKLWIEYRDELSEMK---T-IRIS--RCV--L------------- -PLR-R-TV--FV-ELIG-FSDASQK-GYG-ANLYVR--SVNH-EG------QTAI-R-- LLCA---------------------------KSHV-APL-------K------------- ---EKR--------------------------ALIPRLEICGCV-KLA-QLVDKVKRS-- -L-P----I-E-F---DRI---TC---------YT------------------------- ------------------------------EPQEXPYYFLPHHAV-------VRPE-SST TKL-RVVFDASAKSS-NG---QSLNDQLLVGPTLQ--PRLIDNLLSFR---TYKV--AVT SDVAKMFRQIDVRKE--DRRFQQ-----I------LWRTS---P-DE---------DI-G VYQLTTVTYGTACAPFLATRA-LLQT------------C----IDE-AEHF--P-LAAVF G-KNS--VYMDDV-LFGAE-T---VEEALEMQRQLT-GM-LGKA-------GFELH-KWC SNRS-EL-LAGIPEDKLEQKV------------------------------------LFT EEGKT-----------------KT--LG-------------------------------- -----ITWQPDLDVFSFDI----------------------------------------- ----------------------------------------------------------ER RYPFHQVGIDLCGPVF-------------------------------------------- ----------------------------IKQR--NKRS---TVQH-----KA-WIV---L -FVCLS--TKAIHLELVSELSTAAF-----LAAFDRF-VSRR-GRPAVVWTDNGTNFVGA ANLLA-E-------WDKFFASV-DT------------------QDEIQ---R-AHSNEIT ----WRFNPPEAPHFGGIWESNIKQAKKLLVKHTA--G-----AAL----CFEEM----- --STV-----LARIEAILNSRP--------ITP------------L-------------- ----------------------SN--------DPE--D-------F-------------- ----------- >529/1-584 ----TKRVVASDLSLHWDPLGVAGPVVVQAKIFVQQ-LWRH-Q----------Y------ -DWDA-P-LKE--ADQEFWLEYRRNLKGLE---G-LSVS--RWI--G------------- --VERK-TK--SV-QIHG-FCDASTK-AYG-ACLYVR--TEYE-DG------EVVV-N-- LLTA---------------------------KSRV-API--P-KPKK------------- ---KSKKKTSQKQPEEEQAEQSNPEQDELDAEQTIPRLELSSAL-LLA-HLYXKVANS-- -L-P----F---K---PEA---YF---------WT------------------------- ---------------------------------------LPHHAV-------IRPD-STT TKL-RVVFDASCATS-TG---VSLNDGLMVGPVVQ--DDLYNTVIRFR---FHRY--ALV ADIAKMYRMVRIAEA--DRPLQR-----I------VWRKS---P-TE---------PV-R TFELKTVTYGTASAPYLATKC-LQRL------------A----ADG-EARY--P-LAAKI V-KQD--FYVDDL-LTGVD-D---LEEGMKLINEIL-EL-MESA-------GLSLR-KWN SNCK-QL-LWRVPDHLRDGQS--I-L-EFD---------------------------A-- ASYTV-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------NP CFAFRRVGVDYCGPFY-------------------------------------------- ----------------------------LVHG--LRRG---SPV------KC-FVA---V -FVCLV--TKAVHLELVANLTTEAF-----LAALKRF-SARR-GKPELIKCDNATNFVGA SRELK-E-------LHRLFLNQ-EF------------------QARVV---AQTAADRIE ----FQFIPARTPNFGGLWESAVKSFKTLLKRTVG--A-----RKL----FYDEM----- --QTI-----LTQIEAILNSRP--------LTP------------L-------------- ----------------------SN--------DPN--D-------F-------------- ----------- >53/1-529 ---PTKRKVLQFIASIYDPLGIINPFIVKCKVFFQK-LCIK-K----------L------ -NWDK-P-LEG--KMLLVWQAIINDIQSSK---P-IIIP--RWYHN-------------- ----NYSNHVVDL-SLHG-FSDASNI-AFG-CCIYLL--CSFDDEH------K-IC-S-- LITA---------------------------KSRI-AQI--K-N---------------- --------------------------------TSIPRLELKAAL-LLA-ETMSTVKRD-- -L------Y-PVLKF-KQI---VC---------WC------------------------- -----------------------------------------HQPV-------LRN-DKVT SKV-RIVFDASSS---VD--GPSLNDCLYPGPSLT--TSLYGILLRFR---AQKI--AFV ADIEKAFLQITLSPE--DRDYVR-----F------LWFEN---I-NSLNKDNIFTQKI-I PYRICRVLFGVTSSSFLLSAT-LITH------------A----EKYLSDDP--I-FV-NK L-MNS--LHVDDL-NSGAD-S---IDSAINFYQKCQ-DR-LKEA-------GFTLR-KFE SNCK-QL-ENLVNEQNFT------------------------------------------ ---------------------------S-------------------------------- -----FNL---------------------------------------------------- ----------------------------------------------------------TN DHAFKFTGVDYAGPLY-------------------------------------------- ----------------------------IKNIYEG--N---NLY------KV-WIF---L -FTCAT--TRALFLDLVPDTSAESC-----IRSLRRF-FAKR-GTPSEILSDNGSQFTS- --------------------------------------------NLTQ---NFTSSLGIT ----WHFNIPAAPWWGGFFERLVGSTKRCLRKITH--K-----DQL----SYEEL----- --LTF-----LAEVESILNNRP--------ITF------------M-------------- ----------------------YE--------SPG--D---------------L------ ----------- >530/1-554 ---NTKRQLLSDSSKLFDPFGWLAPVTIKIKILYQH-LWLC-E----------L------ -SWDD-G-LPA--TVEPAWKEIKETLHLLE---Q-IRIR--R-F--A------------- -PNKDGK--I----ELHG-FSDASEA-AYS-AVVYAR--EPDE-TG------QAEM-N-- LLAA---------------------------KTKV-API--R-Q---------------- --------------------------------VCVPRLELNGGT-LLA-NLMLAIVAA-- -L------S-HLE---VEL---YA---------YT------------------------- -------------------------------------CYLPHHAV-------VK-D-STT TKL-RVVFDASCATS-TG---VSLNDRLLAGPNVN--QELFSVFLRFR---TYKV--AFT ADAEKMYRQVWVHPA--DRDYQR-----I------VFRET---E-DQ---------PI-K HYRLCTVTYGTKCAPYLAIES-MKQA------------A----SEF-KLKY--P-EAAQK I-ELD--TYVDDF-LSGAQ-T---VQRAKELKSQVV-EI-LESA-------GFHLR-KWT TNCP-EL-LQHAAETDQTPVEVKL-DERAN------------------------------ ---AV-----------------KA--LG-------------------------------- -----ILW---------------------------------------------------- ----------------------------------------------------------MG TRAFAHVGVDYAGPVK-------------------------------------------- ----------------------------VHAS--CVRG---VKTT-----KG-YIV---V -FVCMA--TKAVHLELASDLSTNTF-----IGALKRF-VSRR-SHPNEMWSDCGTNFVGA DTWLK-E-------IRGALEKH-NV--------------------AAN---RFLTNLGIK ----WVFNPPSAPHRGGLWEAAVKSAKKHLVAVLG--S-----DAA----TFDXF----- --DXT-----SSQNQACSTSRXTAWTSGNWYTD------------I-------------- ----------------------RR------------------------------------ ----------- >531/1-548 ---PTKREVLRTLMMVFDPLGFIAHVLMVLKVLLQE-IWRT-P----------V------ -GWDD-P-IEN--PQYEKWLSWLEIFPRIA---T-VEIP--RCY--R------------- -LLTPLD-EETRI-QMHT-FVDASES-GFA-AAVYLR--FER--ND------VVEC-M-- LVGA---------------------------KTRV-SPL--K-F---------------- --------------------------------LSIPRSELQAAV-IGT-RLADTISKA-- -L------S-INV---TQR---TF---------WT------------------------- -----------------------------------RVWYLPIFPV-------VNPN-K-P GKI-RIVWDAAAT-V-YG---VSLNTFLLKGPDQL--TSLVSVLVQFR---EFRV--AVS GDIREMFHQIKMREE--DQHCLR-----F------FWKDD---D-NT---------TEPS VYVVQVMTFGACCSPSTAQYV-KNCN------------A----KRF-EQDH--P-EAVNT I-VKR--HYVDDM-LVSVE-S---EEEAIQLVQNVK-AI-HASG-------GFEIR-NWI SNSR-NV-VAAV--NE---NASQ---EKNLDI-----------------------GEE-G VA--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TRPFTHMGVDYFGPIL-------------------------------------------- ----------------------------VS--VG-R-----R-TE-----KR-WGV---L -ATCLT--TRAIHLQIAHTLTTDSC-----IMAIRNI-MARK-GIPAMIYSDRGTNFRAA SKELQ-S-------ATEKLDQN-V----------------------LK---KEFTSSHTE ----WSFNPPLSPHMGGVWERLIRSVKQNLERLQT------S-RLP----TDEVL----- --QNA-----LIEIENIINSRP--------LTN------------I-------------- ----------------------PI-------------DD--------------------- ----------- >532/1-576 ---PTKRQLLSFVMSIYDPLGLIAHITIHSKIIMQD-LWRV-G----------I------ -EWDD-K-IPD--SVKEDWSTWIKLLSTLN---N-LRIP--RCY--S------------- -YAK-NI---IKR-ELHV-FCDASAR-AYA-TVIYIR--TIHD-KG-------IDL-T-- IVAG---------------------------KSKV-APT--K-I---------------- --------------------------------MSIPRLELQAAV-LGT-RLTNTVQKE-- -I------R-LEI---NTI---TH---------WS------------------------- -----------------------------------RTFYLPHFII-------ENKN-KEP PKR-RLVFDAAAK-I-NG---ISLNSQLLSGPDMT--ESSLGIKMRFR---EEPI--AVS GDIQEMFHQVGIRKE--DRNSQR-----I------VSRK----N-PN---------ERLD IYEMQVMTFGATCSPACAQYV-KNTN------------A----KQF-LNTC--P-EAVEA I-LKN--HYVDDY-LDSFN-D---LNKATKIVLDVI-KI-HDKA-------HFKMR-NFI SNSK-SL-LANL--------PSDRISALNE-I-----------------------KLDMD ENVFE-----------------KV--LG-------------------------------- -----MYWNTDKDNYKFKITAKFDEIQDPTKRQLLSFVM--------------------- ----------------------------------------------------------PY VKPFTHTGVDYFGPYN-------------------------------------------- ----------------------------VS--IG-R-----R-TE-----KR-WGV---V -FTCMT--TRAVYLEVAHDLSADAF-----LVCLNSV-QSRR-GKIKFLYSDNGTNFVGA DNELK-K-------IRYRL-----------------------------------ASDGIV ----WTFNPPLSPHFGGAWERMVREIKSLLPS---------D-TMP-----EHTL----- --RAL-----LTEIEFIINCRP--------LTS------------I-------------- ----------------------SL-------------DATDDEPITPHHF---------- ----------- >533/1-561 ----TRRVVASDLAKLFLPLGLLGPVIVLAKIFVQS-LWEE-N----------K------ -SWDA-P-LKP--EQQQYWWEYRNSLEDIP---S-ISIP--RWV--A------------- --CASD-PV--LV-ELHG-YCDASER-AYG-ANIYIR--TVSR-DG------TISV-R-- LLCA---------------------------KSKV-APS--G-KSKN------------- ---SVL--------------------------LSLPLLELSSAL-LLA-HLYHKVAAS-- -L-D----L---K---TKP---FF---------WT------------------------- -----------------------------------PSYYLPHHGV-------EKAD-STT TKL-RVVFDASCRTD-SG---VALNQALMVGSVVQ--DDLFAIHLRFR---MNRI--ALI ADIEKMYRQIRIHPS--DYQLQR-----I------LWRNS---S-SE---------PL-R TFELTTVTYGTASAPFLATRC-LNEL------------S----KQG-AEDY--P-LASLA L-GRD--FYVDDM-LTGVY-D---EEEGEELCKQLL-SL-LPSA-------GFSLR-KWA SNSA-EV-LSKIPPELRDERS--V-L-GLE---------------------------S-- HTTPI-----------------KT--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------TP TLPFLNTGVDLCGPFQ-------------------------------------------- ----------------------------YRKA---PRA---APT------KC-YVA---I -FVCLV--TKAAHIELVYDLSTAAF-----LAALHRF-IARR-GKPKLIQCDNATNFKGA ERELE-K-------LRKQFINQ-QL------------------QAAVV---NRCADDGID ----FKFIPPRSPNFGGLWEAAVKSFKKHLRATIG--N-----SVL----SQDEF----- --VTL-----LARIEACLNSRP--------LTP------------L-------------- ----------------------SA--------DPN--D-------L-------------- ----------- >534/1-568 ----TKRIVTSIVARLFDPLGLIGACVVGAKIYLQE-LWDL-I----------DKETGKP IDWDT-E-LPA--TVGEKIRRFLLKIPHLN---E-LRIP--RCV--L------------- --AR-G-AT--KF-ELHC-FTDASEK-AYG-ACIYLR--SMDA-EG------NISV-H-- LLTS---------------------------KSKV-APR-------K------------- ---L----------------------------QTLPRLELCGAY-LGA-LLVEKVLQA-- -L-K----V-S-----VNV---YY---------WT------------------------- ------------------------------SRANVKRCFLPHHPV-------LRES-STT TKC-RVVFDASCKTS-TG---VSLNDTLLVGPIVQ--QDLRTIMLRAR---VRQV--MLV ADVEKMFRQIDMDPE--DRPLQS-----I------KWRFG---P-DE---------EV-A SYELSTVTYGTKPAPFLATRT-LKQL------------A----TDE-RERF--P-LAAES V-DDD--IYMDDV-ICGAA-D---LDTAINLRQQYD-GM-MASG-------GLRLR-KWA SNWE-DA-LKGVPNENLAFAD--E-V-SWD---------------------------Q-- -DASV-----------------KT--LG-------------------------------- -----LTWLPRTD----------------------------------------------- ----------------------------------------------------------TA CKPFLKVGLDFFGPVF-------------------------------------------- ----------------------------TKAG--RGRT---A-I------KS-YVA---V -FVCMC--TKAVHMEHVSDLSTERF-----LQALRRF-IARR-GRPSDIYSDNGTNFVGA RNQLL-E-------LFNMLESD---------------------REVIC---REATKEGIN ----WHFNPPSAPHFGGLWEAAVRSAKYHLLRVLG--N-----STV----SAEDF----- --NTL-----LVQVEGVLNSRP--------LTP------------L-------------- ----------------------SD--------DPT--D-------L-------------- ----------- >536/1-565 -----KRVVLSKAASLFDPHGWFGATITTAKIFLQQ-LWTL-V----------D-ADGKR LDWDT-P-LPP--TVGENWRKYEEQLPVLN---S-IRFA--RCV--V------------- --IP-N-AE--KV-ELHC-FSDASKK-AYG-GCVYVR--SENA-AG------DVMV-R-- LVAS---------------------------KSRV-APL-------K------------- ---V----------------------------QTIPRLELCGAT-LVA-QLFKVLQEA-- -L-D----I-P-----LSA---HF---------WT------------------------- ------------------------------ETDTVKRCYLPHHPV-------VREA-STT TKV-RVVFDASCKTS-SG---VSLNDALLCGPVIQ--QDLRSLIYRCR---IKQI--MLV SDVEKMFRQIGITPE--DRALQC-----V------LWRPT---P-SA---------EV-C TYELNTVTYGTKSAPFLATRA-LKQL------------A----MDE-KHRF--P-LAAKA I-SED--VYMDDV-ITGMD-D---EDAARNLRIQLD-EM-MISG-------GFRLR-KWA CNRA-EV-LRGVAEENLAIPFPEG-I-NLD---------------------------K-- -ESSV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV SRPFSKTGIDFFGPVY-------------------------------------------- ----------------------------VRPG--PRRT---A-V------KA-YVC---L -FICLC--TKAVHLELVSDLSTDRY-----LQALRRF-IGRR-GRPAEIWSDNGTNFVGG KNRLQ-E-------LFALMKDS-EH------------------KEKVA---KEFADQGIR ----WIFSPPSAPHFGGLWEAAVRSAKHHLLRVLG--E-----ETL----AIEDM----- --TTL-----LVQVESCMNSRP--------ITQ------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >537/1-553 ---PTKRQVLSTVMSFFDPLGLIAHFVIQGKVLMQD-IWRS-G----------T------ -EWDE-P-IAD--SLHDKWIKWSQHMKEMA---A-VRVP--RCF--F------------- -SGADHI-AMKGM-QIHV-FVDASPE-AYA-CVAYLR--IVD--NG------VPRC-A-- LLAA---------------------------KSKV-APL--K-P---------------- --------------------------------VSIPRLELQAAL-IGS-RLAETFCGY-- -L------S-IPV---KQR---FF---------WL------------------------- -------------------------------------WYLQLSLVLAPKCGPQNPK-K-P EKI-RLIWDAAAR-S-GG---VSFNDMLLKGPDLL--TSLVAVLVRFR---QRNI--AIC GDIREMFHQIAIRDL--DKQAQR-----F------LWRRS---S-DC---------S-PE CFVMDVATFGATCSPSSAQFI-KNKN------------A----EEF-AEQY--P-AAANA I-IKS--HYVDDY-LDSVD-T---VEEAVQLWNDVR-YV-HAQG-------GFEMR-NLI SNSS-EV-MQHV--GE-TGNT----TVKSMNL-----------------------D-ETQ DN--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------SF IRPFTNTGVDYFGPIT-------------------------------------------- ----------------------------VK--QG-R-----N-NV-----KR-WVV---L -FTCLS--VRAVHLEIAHSLTSQSC-----VMAIRRF-VARR-GAPETIWSDNGTNFVGA NNILK-E-Q------LLK-INE-S----------------------CA---ATFTNARTS ----WRFNPPYAPHMGGAWERLVRSVKTAMITINE--H---I-HRP----SDEVL----- --ETV-----ILEAEAIVNSRP--------LTY------------V-------------- ----------------------PL-------------DS--------------------- ----------- >538/1-578 ---WTRRRIMSTIATLFDPIGFVGPVIAAAKILMQK-LWTL-E----------D-KNGKK LDWDD-E-LPL--AIVQKWLKFYEQIPALN---D-LTFP--RCV--I------------- -IPKAV-----NI-EIHT-FCDASQD-AYG-ACSYVR--SVNQ-AG------EVRV-A-- LLSS---------------------------KSKV-APL--K-C--Q------------- ---------------------------------SIPRLELCGAE-LAA-LLGEQIFKA-- -TKL--------D---VKY---YY---------WT------------------------- ------------------------------DLGEVKRVFLPHHPV-------VRES-STT TKV-RVVFDASCASS-TG---VSLNDALLVGPSIQ--DDLRSIILRSR---TKQF--MLV SDMEKMFRQVLVTEE--DMKLQS-----I------MWRDD---P-NK---------EV-K VYELATVTYGTKPAPFLATRT-LKQL------------A----MDE-QSRF--P-MAAKV A-LED--VYMDDV-LTGAD-D---EDQAVELRTQLD-AL-LESG-------GFRLR-KWA SNSP-LV-LQGIPDENLALSRTGD-V-LLD---------------------------P-- -DPSV-----------------RT--LG-------------------------------- -----LVWRPTTDVLKFQF----------------------------------------- ----------------------------------------------------------TV ARPFSKVGVDYFGPVY-------------------------------------------- ----------------------------IRPG--PRRV---A-I------KA-YVA---V -FVCMC--TKAAHLELVTDLSTDRF-----IQALRRF-IGRR-GLPAEIFSDNGTNFVGA RNRLQ-E-------LFELLRSK-DH------------------SEKVS---KECADQGIQ ----WHFNPPGAPHFGGLWEAAVRSAKTHLLKVLG--D-----NPV----SYEDM----- --DTL-----LVQVEACLNSRP--------LTQ------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >540/1-557 ----TQRIVLSDSARLFDPYGLVGPVIGQAKMFLQE-LWKQ-K----------Y------ -SWDE-P-LSP--DLQSQWLEFRTNLDRID---A-VSVP--RWI--A------------- --FSDN-VV--SC-ELHG-FCDASEK-AYG-AVIYLR--CVTQ-KG------EVTV-R-- LVMA---------------------------KSKV-APL--E-DLKR------------- ---KKKR-------------------------QSIPRLELSSAL-LLA-HLYETVAES-- -I-Q----I---P---AKT---YF---------WT------------------------- -----------------------------------HTYYLPHHAV-------MKPD-STT TKL-RVVFDASCATD-TG---VSLNDTLMVGPVVQ--SDLLSILIRFR---LHKY--AIV ADVEKMYRMINVVEQ--DQPLQR-----I------LWRES---V-EE---------PL-R TYQLSTVTYGTSSAPYLATRS-LKKC------------A----EEG-EQXY--P-XAANI I-KHD--FYVDDM-LAGAX-S---VKEGXXLCKDVL-SL-LGSF-------GFNLR-KWH SNQP-AI-LKSIPSHLHDKRD--L-L-DID---------------------------T-- -TSTV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TP APVFLRVGVDYCGPFN-------------------------------------------- ----------------------------VRQG--SRKA---APV------KC-YLC---V -FVCLV--VKAVHVEMVADLTTEAF-----IAALRRF-VARR-GKPEVIFCDNATNFVGA RREIS-E-------LHRLFRAE-QF------------------QNAVV---SDAAKDSIE ----FKFIPAKSPNFGGLWEAAVKSLKGHMRKVIG--N-----TVL----RSDEF----- --LTV-----VTQIEACLNSRP--------ITP------------I-------------- ----------------------SS------------------------------------ ----------- >541/1-550 ---STKRSMLSVTAXIFDPMGLVSPCIVPIKILLXR-LWVH-K----------L------ -SWDE-Q-LPF--EIAKIWANLIKSLPLLN---N-LRIP--RLI--G------------- -CEAYT-----YV-DLHM-FTDASQS-AYG-ACLYVR--SADV-YG------RIKV-S-- LLIA---------------------------KSKV-APL-------K------------- ---L----------------------------TTIPRLELCGAL-VGV-RLYEKAIDS-- -L-R----V-Q-V---RHT---TF---------WT------------------------- ------------------------------QPTDSTVYYIPHHGV-------LNEN-STT TKL-RVVFNASSPTT-SG---ISLNQIQMVGPTVQ--DELLSILLRFR---LYKY--VLA ADVEKMYRQIAVHPE--DRCLQK-----I------LWRAS---T-DC---------PI-Q MYQLNTVTYGCASSSYLATRC-LKQI------------G----LEC-SDKK-----ISEI I-IHD--FYVDDL-LTGSD-S---FQEALYIKKKVA-AE-LASA-------RMPLR-KWK SN---------DPL--LCLTG--DPSDNSSSL-----------------------SLNIG SLESC-----------------KT--LG-------------------------------- -----LNW---------------------------------------------------- ----------------------------------------------------------TP GRPFECVGIDYAGPIS-------------------------------------------- ----------------------------SANR--LGRG---CRIV-----KV-YIA---I -FVCFK--TKAIHIELVGDLTSNSF-----LSALRRF-VSRR-GKPTHIYSDNGTSFVGA YKQIG-----------TFLKSN-CN--------------------SLP---DALIEEGIN ----FHLCPPYSPHFGGLWEAGVKSIKFHMHRVLG--N-----CNL----TYEEL----- --ITV-----LTQIEAILNSRP--------LTP------------L-------------- ----------------------SS------------------------------------ ----------- >546/1-547 ---PTKREILRILMSIYDPLGLIGHLLMYLKILLQE-VWRA-K----------V------ -TWDE-E-VTG--TLLDKWRVWLSVLPSIH---A-VNIP--RCY--R------------- -QVTMDX--GSSI-XLHV-FCDASEN-GMA-AIAYFR--FEE--NG------VIEC-A-- LVGS---------------------------KTKV-APL--T-F---------------- --------------------------------TSIPRLELQAAV-LGA-RLANAXKAS-- -H------R-LHI---AXE---VF---------WT------------------------- -----------------------------------NDWYLPIFPV-------INPN-K-P GKV-RVVFDAAAK-V-NG---VSLNSVLLTGPDQL--VGLLTVLYKFR---ENKI--AVT GDIREMFFQVRMNER--DQRSQM-----F------FWNDG---K-IG---------STPQ QYVLSVMTFGAACSPSTAHYV-KNKN------------A----DRF-LKEY--P-RAVEC I-KYE--HYVDDM-LASVE-S---EEEAIRLARDVR-FV-HSQG-------GFEIR-NWL SNST-RV-KTVM--NG---NDTE---SFERPI-----------------------EME-M AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY QHPFSYTGIDYFGPMI-------------------------------------------- ----------------------------VA--VG-R-----R-TE-----KR-WGV---I -FTCLT--TRGIHIEVAHSLSTDSC-----IFAIRNF-TARK-GXPLEFVSDRGTNFVGA SRELK-E-------AAALIDXD-R----------------------LM---AEFVQPGTK ----WVFNPPAAPHFGGSWERLIQSVKKTLSSFDL------P-HNP----TDELL----- --RAR-----LSEVELIVNSRP--------LTD------------V-------------- ----------------------PV-------------ED--------------------- ----------- >548/1-504 ----TKRAILSKLSGVYDPLGIISPTTVEGKRIYRD-ACEE-K----------R------ -GWND-E-VSE--STKKAWFKWTGQL---R---N-VKIP--RSL--V------------- ----RDLRRVKTI-HLHV-FADASNV-ACS-AVMIAI--V-ED-TT------GVVK-G-- LLTS---------------------------KSRI-SKR--N------------------ --------------------------------TSIPRLELVSGH-MAA-NMVKNVCAA-- -L------KRWPI---TSV---TV---------WM------------------------- --------------------------------------------------------NAQT TKV-RMVFDASCKPH-PL--ANSVNECMHTGPPLQ--PLMWDIMIRAR---MAPH--LIL GDLEKAFLQIAIKEE--DRDAFR-----F------LFNIN---D-KEEH----------- -FRFARVPFGAEASPFMLGAT-IHHH------------L----DRQPTELT--N-TV-NA L-REN--TYVDNL-MQTGN-D---VDELKEFREEAT-RI-FESA-------KFPAH-KWE SDLH-EL-DTEPNPS--------------------------------------------- ----------------------KI--LG-------------------------------- -----HVW---------------------------------------------------- ------------------------------------------------------------ --PFETVGVDLAGPL--------------------------------------------- ----------------------------YKL--A--KN---GKG------KV-YII---I -FTCAT--SRAVHLEVTKSQTAEEF-----QRKLNAF-ITRR-TRPVRIVSDNASVFKAT ATWIK-K-------IRKS--------------------------EVLQ---DYLAKQGIR ----WQFNLSRSPWWGGMYERLIREIKKTLYKTMG--R-----SSL----HYEQM----- --EEV-----VVDIERHLNNRP--------LTY------------V-------------- ----------------------ES------------------------------------ ----------- >549/1-557 ---WTKRKILSRVARLYDPIGYTAAVVIKAKIGIQK-LWQL-G----------Y------ -EWDQ-P-IEP--PLAQTWEAFFTDLDELN---K-IELP--RCL--T------------- -PPNAVG----LP-TLCI-FSDASRE-AFG-AVAYLR--WQAS-VG------SYEV-R-- FVAA---------------------------KSRV-APL--K-E---------------- --------------------------------LTIPRLELQAAV-LAA-RLHQTLQEE-- -L------R-IEC---EKA---IL---------FT------------------------- ---------------K---------------SYQGPVHYISHHGV-------ARPE-SDS TPL-RIVFNTSAT-Y-QG---HALNDYWMKGPDLL--NDLFGVLLRFR---EGQC--AVI GDLSKMYHRILIPEA--DQHVHR-----Y------LWRNL---E-TE---------RPPD VFVKTVLTFGDKPAPAMAQIA-LRKT------------A----EEG-EKEY--PEAA-KV L-KED--TYMDDI-CLSEE-T---PDKVQQLVKDLD-KV-LQNG-------GFHVK-KWT TSGS-AK--DDDAAELDLLKTEHEEKVLGIAW---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY TPPFFHTSCDYFGPIN-------------------------------------------- ----------------------------VR--IG-R-----NKSD-----KY-YGV---I -FTCLN--TRAVHLEMAVDLSTMDF-----LQVLRRF-FSIR-GYPATVLSDNGSQMVGA ERELR-E-------LIKGLNDD-Q----------------------LR---QFNAEKGIW ----WIFITPAAPHQNGCAEALVKTCKTALKKAVG--E-----QTF----TPMEL----- --YTC-----LLEAGNLVNKRP--------IGR------------I-------------- ----------------------PN-------------DPDDGKYLCPNDI---------- ----------- >551/1-535 ---TTKREVLSVIMKIYDPLGLLANHLIEAKLIMQE-MWRL-G----------H------ -NWDD-K-LPI--VIINQWNAWVKSMKIVE---K-INIK--RCY--S------------- -QTNHSI---TRR-EIHV-FVDASDK-AFA-AIVYMR--TISS-NG-------IEV-S-- PIAA---------------------------KSRV-API--K-P---------------- --------------------------------LSIPCLELQGAV-LGV-RLADTILKE-- -L------R-VHI---NDT---FY---------WT------------------------- -------------------------------------NYIPHFAV-------INYN-KPK PKP-RLVFDAAAK-N-AG---ISLNSQLLTGPDAV--ASLFGILVRFR---EGSV--GVS GDIKEMFHQVKIRQQ--DQSAQL-----F------LYRE----S-PT---------SIPK TLKMNVMIFGATCSPACAQYV-KNEN------------A----KQF-INIH--P-EAVTA I-IQN--HYVDDY-LDSFD-T---EEAALERVSEVI-TI-HDEA-------NFFIR-NFI SNSK-GL-LNNL--------AAERVSESSL-L-----------------------KITEK DQTYP-----------------KI--LG-------------------------------- -----QWW---------------------------------------------------- ----------------------------------------------------------AY FKPFTHTGVDYFGPLT-------------------------------------------- ----------------------------VT--IG-R-----R-SE-----KR-WGA---L -FTCLT--TRAVHLELANDLSSNTF-----IMILKNM-QHRR-GKIAHIYCDNGTNFVGA CREMA-Q-------IQQRC-----------------------------------ATEGIY ----WHFNPPAAPHFGGAWERMVQEVKSLFPLT----K---D-SLP-----EVAL----- --RSL-----LIEIEFIINNRP--------LTH------------I-------------- ----------------------PI-------------EH--------------------- ----------- >552/1-569 ---MTRRKLLSQLAKIFDPLGFFGPVITYAKLILRE-VGEL-Q----------I------ -DWDD-S-IPT--EIDEKWRNFRTEMTSLR---E-IRVP--RWI--S------------- --WKDVFQL-----RLQG-FADASDQ-AYG-ACLYVQ--GTFT-DE------ESKM-Q-- LVCS---------------------------KSRI-LPK--K-RSPK------------- ---EKA--------------------------ITTPRAELLAAL-LLA-RMVVKFLNA-- -TE-------LKF---ESV---HL---------WS------------------------- ------------------------------NDDPGSVFYLPHHCV-------LRPT-STT TKL-RVVFDGSAKTS-TG---VSINDVLMTGPTVQ--NDLTAILLRFR---GFQY--VFT LDIPKMFRQVVVHPD--DTRYQR-----I------FWRYN---R-ND---------PL-T VRELLTVTYGLGPSPFQATMA-LKQA------------A----EDH-HDEF--P-RAAEV V-NRE--TYMDDI-LTGAD-T---LAEACQLQRDVT-GL-LAKA-------CFSAH-KWC ANHS-DI-VLGVAEEQRGDTF------EVT---------------------------DDT SKTIV-----------------KT--LG-------------------------------- -----VTW---------------------------------------------------- ----------------------------------------------------------QP APVFSNTGVDYAGPFW-------------------------------------------- ----------------------------IK-STTSRKP---QIT------KA-YVC---L -FVCLQ--TRAVHLELVSDLTTDAF-----LASLRRF-ISRR-GCPKTIRSDNATNFVGA KTELH-E-------LWRMFEND-CA------------------TKKIT---NYCVDKGID ----WSFIPPRSPHFGGIWEAGVKQVKYHLKRIVG--D-----RKL----SYEEL----- --YTT-----LTQIEAVLNSRP--------LVP------------S-------------- ----------------------SD--------DPS--D-------Y-------------- ----------- >553/1-563 ---PTMREVLSFVMSIYDPMGLISHLTIHGKILMQK-LHTE-M----------T------ -DWDE-E-LSP--QSQQQWNQWLTNIAQAK---D-IRIP--RWI--L------------- -CNQ--A---KTF-ELHV-FVDASEY-AFA-TTIYTRGVGAYG-QT-------VSV-K-- LVTA---------------------------KAKV-APV--R-K---------------- --------------------------------LSIPRLELQAAV-LGA-RLAQTIQEE-- -L------R-IVP---SRT---TY---------WS------------------------- -----------------------------------EIYYLPHFIV-------YNKN-KVP PKP-RLVFDAAAK-N-KG---VSLNSVLLAGPDAT--TSSFGVTTRFR---EGKY--ATA GDIKEMFCQIKINTE--DQKKQC-----F------LFRDF---D-MT---------RKPD VYTMQVMTFGATCSPACAQIV-KNHN------------A----EQF-KEIK--P-KAAKA I-KTQ--HYVDDY-IDSFN-T---VEEAIGTIKDVT-EI-HQQA-------GFYIR-NFV SNDK-NI-LAAL--------PQERVQQNPL-K-----------------------QLEDK DTLNE-----------------KV--LG-------------------------------- -----VYW---------------------------------------------------- ----------------------------------------------------------MY AYPFTHTGVDYFGPIE-------------------------------------------- ----------------------------VQ--VK-R-----S-IE-----KR-WGV---I -FTCMS--TRATHVELAERLDTDAF-----LVCLKNF-QNRR-GKVQHLYSDNGTNFIGA EKEMK-A-------AINEIDKK-F----------------------GG---SIAAAMEIN ----WTFNPPAAPHFGGAWERLIQSIKKCLKAMPE--CTQ-M-RKP----TIEEL----- --RSA-----LIQAEFILNSRP--------LTH------------I-------------- ----------------------SL-------------DNEDEEPLTPFHF---------- ----------- >554/1-558 ---PTKREMLQVLMSIFDPLGLIAHFLGYLKVVLQD-VWRS-R----------V------ -DWDE-P-VHI--EELKKWMIWIKLLPQIE---Q-VKIT--RCY--S------------- -QQYSIN-GAEDV-QLHT-FVDAGGS-GMA-AIVFLR--VVH--GQ------NVRC-S-- IVTS---------------------------KTKV-APL--K-L---------------- --------------------------------TSVPRMELQAAL-IGA-RLASTVEKA-- -L------K-IKI---SRK---IF---------WS------------------------- -----------------------------------VKWFLPIFPI-------KNPN-K-P GKI-RIVWDAAAKSS-HG---LSLNCMLLQGPDLL--CSLLNILLCFR---LGQI--AIA GDIREMFHQISMRRE--DQMYQC-----F------YWTEQ---D------------GELA VYAMTVLTFGACCSPCTAQFV-KNRN------------A----ERF-QTTH--P-KAYEA I-VHS--HYVDDL-LVSVE-T---ESEALQLINDVK-TV-HSAG-------GFEMR-NWI SNCK-SV-EAYV--NG---SVST---EKCMNF-----------------------SSK-S HV--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------VF SRPFTHTGIDYFGPIE-------------------------------------------- ----------------------------VA--VG-R-----S-NQ-----KR-WVM---L -AICLT--TRAIHLELVQTLTTSSC-----IIALRNF-ISRR-GRPRKFYSDRGTNFIGA QRELA-K-------LDKEFNEK-D----------------------IA---KEFVDADTE ----WEFITPAAPHMGGSWERLIRTVKSNLMAACT------S-KKL----SDEIL----- --NNL-----LIEIENVVNSRP--------LTH------------V-------------- ----------------------SI-------------DHDAAPALTPNHF---------- ----------- >555/1-558 ---PTKRVVMSSVMSLFDPLGMLATFVIHGKMLIQD-LWRS-G----------S------ -DWDQ-P-IDD--GSCEKWDRWIARLPEIE---Q-VKIP--RYY--F------------- -HGSRSV-DYDTL-QLHV-LVDASQD-AYG-AAAYFR--VLTS-DG-------PAC-F-- LVMA---------------------------RSKV-APL--K-M---------------- --------------------------------MSIPRLELQAAV-IGA-RLLQTVVEA-- -H------S-LDI---KQR---FI---------WS------------------------- -------------------------------------WYLLISVV-------VHPK-K-P GKV-RLVWDAAAA-V-NG---VSLNSKLLKGPDML--TPLPNVLAKFR---ERVV--GFG GDIREMYLQVRVRAA--DKRA-R-----F------VFRNS---A-SE---------E-MK IYIIDVTMFGATSSPCTAQFV-KNRN------------A----EEY-AGQF--P-EAARA I-VEN--HYVDDY-FDSTD-T---VEEAVKRAQEVI-FV-HSKG-------GFEIR-NWV SNSE-EF-LHGI--GE-----RTPDQNVQILQ-----------------------D-KES NL--E-----------------RV--LG-------------------------------- -----IVWNPVSDEFTFLAKLR-------------------------------------- ----------------------------------------------------------PG WRPFSFTGVDYCGPIM-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WIC---L -FTCLT--TRAIHLEVAHSLTTQAC-----LMAIRRF-VCRR-GKPVEFYSDNGTNFQGA SKEV-----------IQK-IDG-E----------------------CE---EAMTDARTR ----WNFNPPSAPHMGGVWERLVRSVKAALAV-LN--D---G-RRL----TDEVL----- --LTT-----LAEAEDLVNSRP--------LTY------------A----GLGPEAG--- ------------------------------------------------------------ ----------- >556/1-552 ----TKRSVLSAIAKMYDPLGMIAPIIIRAKMIMQE-IWVS-S----------R------ -DWDE-S-LPE--DIVCKWKQFQKEIRSLS---Q-YRMD--RFI--L------------- --LP-E-AR--NI-ELHT-FADASSA-AYG-ACTYVR--CEDA--G------RVRV-M-- LLAS---------------------------KSKV-APL-------K------------- ---N----------------------------LTIARLELCACV-LAA-HLHHRIKGA-- -I-D----V-A-V---NAS---YF---------WT------------------------- -------------------------------------------------------S-STT TKI-RVVFDGSSKTT-SG---YSLNDALCVGPVVQ--DDLLDQLLRFR---TYKV--ALV GDIAKMYRQILLHPD--DRPLVR-----I------LFRFE---P-QQ---------PV-Q TYQLNTVTYGLAPSSFLATRA-LIQL------------A----DDE-GNAY--P-RAGPA L-RKN--FYVDDF-IGGAQ-S---VEEATCLRTELA-EL-LQKG-------GFELR-KWT SNCV-DV-LHGLDEAQVGTTT--K-M-SFD---------------------------S-- -HEAV-----------------KT--LG-------------------------------- -----ISWVPQGDWLVFEG----------------------------------------- ----------------------------------------------------------IP SRPFAVTGVDYAGPLY-------------------------------------------- ----------------------------LKPA--HRRA---ASL------KA-YLC---V -FVCFA--TKAVHLELVGDLSTDGF-----LAALRRF-TARR-GVPDHLHSDNGKNFEGA RNELR-E-------LFATLTSE-AA------------------QSTIA---SSCADQGIS ----WHMIPPRAPHFGGLWEAAVKTAKRHLFRHLG--S-----TRL----SFEGY----- --YTV-----LHQIEAAMNSRP--------LLP------------L-------------- ----------------------TD--------DPN--D-------L-------------- ----------- >558/1-538 ---PTKREVLRTLMSIFDPLGLLSNVLIFLKVLFQE-IWRS-S----------I------ -DWDD-E-IPN--NLHEKWEHWLRILPKVQ---D-VSIP--RCY--R------------- -SVTSLS-SETVI-QLHT-FVDASEL-GYA-AVVYLR--FQQ--GD------AVEC-A-- IVGA---------------------------KSRV-APL--K-F---------------- --------------------------------VSIPRLELQGAV-IGV-RLARTISKA-- -L------S-FKI---DEF---FY---------WT------------------------- -----------------------------------RKWYIPIFPV-------FNPN-K-P GKV-RIVWDWAAK-T-NG---LSLNSMLFKGPDQL--VPLNDVLYMFR---ENKV--GIS GDIREMFLQVRIAKE--DQYCQL-----I------LWKEN---P-AD---------DAPS TFVTQVMTFGACCSPSCAQYI-KNVN------------A----EKY-ADKY--P-RAVEA I-TKQ--HYVDDM-LVSVE-T---EEEAIQLAQNVR-GI-HAKA-------GFQIR-NWI SNSP-AV-VQAL--EQ---EKTE---QKSLNI-----------------------GSE-L ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY ARPFSYIGIDYFGPMM-------------------------------------------- ----------------------------VV--VG-R-----R-SE-----KR-WGV---L -ITCLT--VRAVHLEIAHFLNADSC-----IMAIRNF-MARR-GVPIRIYSDRGTNFVAA SKELK-E-------ALKDLDQE-R----------------------VI---QEIVSQQTE ----WTFLPPASPHMGGAWERLVQTVKANLLQMKP------G-RLP----TDEVL----- --RNC-----LMEIENLLNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >559/1-563 ----TKRIVLAEAARLFDPLGLIGPVVVIAKIFLQE-LWKH-N----------C------ -AWDD-H-LPE--AMQLFWQEYRMNLTALS---S-LSIP--RWI--G------------- --FKTE-AV--SV-ELHG-FCDASDK-AYG-ACIYTR--CTLM-DA------SVEV-R-- LLIA---------------------------KSRV-APL--E-DLKR------------- ---NKKR-------------------------LSTPRLELSSAL-LLC-HLYEKVKSS-- -I-R----I---P---HDA---SF---------WT------------------------- -----------------------------------PAYYLPHHAV-------FKLD-STT TKL-RVVFDASCKTS-TG---VSLNDALMVGPVIQ--EDLISIALRFR---LFCV--AIV ADIEKMYRMILVQPQ--DQHLQR-----I------LYRDS---P-DG---------PL-K TYELTTVTYGTASAPYLATKC-LQRL------------A----NDE-ASDY--P-HAAKV L-RED--FYVDDM-LTGAN-N---VEEAKLLATEMV-EL-TASA-------GFNLR-KWN SNSK-EL-LAQLPHELLDSRA--L-L-ELD---------------------------S-- SSSPV-----------------KT--LG-------------------------------- -----LQW---------------------------------------------------- ----------------------------------------------------------SP APPFLKVGVDYCGPFF-------------------------------------------- ----------------------------VANA--NRRA---APR------KY-FLA---V -FVCLV--TKAVHLELVGDLTSAAF-----LAAFKRF-VARR-GRPILVMCDNALNFVGA RRELS-E-------LHRLFRNQ-QF------------------QQSVT---NGAEEDEIE ----FRFIPARSPNFGGLWEAAVKSFKGHFKRTIG--T-----KIL----PHDEM----- --QTA-----IVQVEAILNSRP--------LTP------------I-------------- ----------------------SS--------DPM--D-------F-------------- ----------- >56/1-567 ----TKRVICSELAAIFDPLGLVSPLIIVAKIILQE-LWLA-G----------L------ -TWDE-S-LPQ--HLELAWKKYLESFQSIS---S-LAVP--RYI--K------------- --QVNQ-SV--SF-QLHG-FCDASER-AYG-CAIYVR--ATYK-CG------QIGV-H-- LLCA---------------------------KSRV-APT--A-K---------------- --------------------------------KSLPRLELCAAH-LGA-QLADRIRCD-- -L-N--------D---STTVPGYF---------WS------------------------- -----------------------------------NHYFIPHHCV-------LKPD-SST TKL-RVVFDASCKTS-NG---KSLNDILLVGPTLQ--SDLYLLLLRFR---LHKY--VFT ADITKMYRQVWINPN--DRFNQM-----I------VWRAN---P-ND---------PL-R TYRLKTVTYGTASAPYLAIRC-LNHL------------A----NLC-RTEY--P-IGAAV I-EDS--FYVDDL-LTGAD-S---IETAITIKDELV-KI-LLRG-------GFPLR-KWC SNHA-QI-LEGIAKKDL--------NT-CE------------------------------ -NGLT-----------------SA--LG-------------------------------- -----VSWNQHTDMLLFF------------------------------------------ ----------------------------------------------------------TP TRPFLTTGVDYCGPIW-------------------------------------------- ----------------------------IHHK--VRGK---RPD------KA-YIA---V -FCCFS--TKAVHLELVSDLTTNAF-----LGALRRF-LSRR-GKCQTIYCDNATNFVGA NNQLK-E-------LGESIFGE-KA------------------QAAIS---NHCNSKQVA ----FKFIPPRAPSFGGLWEAAVKSAKRLLVTTTN--T-----ASL----TFEEL----- --NTV-----IIEIEAILNSRP--------ITP------------M-------------- ----------------------SN--------DPN--D-------NALTPHF-------- ----------- >560/1-565 ---XTKRSILSAVSKHFDPLGLTAPXVIRAKMLLQE-LWLQ-P----------C------ -GWDD-E-VSD--TIQAKWDTYCAELPKLS---T-FRVG--RYA--F------------- --LP-N-ST---I-HLHT-FADASQH-AYG-ACIYAR--STNI-EG------KIHV-Q-- LIAS---------------------------KSKV-APL-------K------------- ---R----------------------------LSIPRLELSAAV-LAV-RLHQKVLLA-- -L-D----I-P-I---SAS---YF---------WS------------------------- ---------------------------------------LPHHAV-------VKEA-STT TKV-RVVFDGSAKTT-TG---HSLNDALLVGPIIQ--DELLTLIIRFR---KYPI--ALV ADIAKMYRQVLLHHE--DVPLVR-----I------LWRFN---S-SE---------PI-S VYELLTVTYGLGPSSFLATRT-LQQL------------A----ADE-GDSY--P-LGGPA L-KKG--FYVDDY-IGGAE-T---EEEAICLRNELD-DL-LEKG-------GFQLR-KWA SNNP-TV-LEGLEPSRIGTQL--A-L-XLG---------------------------N-- -EESI-----------------KT--LG-------------------------------- -----VSWEPRTDQLRFDS--------------------------MQV------------ ----------------------------------------------------------TP SRPFSITGIDYAGPVY-------------------------------------------- ----------------------------MKPI--HKRA---SPT------KA-YIS---V -FVCFA--TKAVHLELVSDLSTPAF-----LTALRRF-IARR-GCPLHIHSDNGKNFQGA QNELH-Q-------LYELMQKE-KS------------------SGKIA---TYCSSQGIQ ----WHMAPPKAPHFGGLWEAAVKIAKKHMHRQLG--N-----AML----SFEDM----- --STV-----LAQIEAAMNSRP--------LTP------------L-------------- ----------------------NE--------DPN--D-------L-------------- ----------- >561/1-543 ----TRRKVLSEVARIFDPLGLIGPVLTTAKLFLRE-IADT-T----------T------ -DWDA-P-LPQ--AFVNRWKLFREGLVTMN---R-LKIP--RWI--L------------- --SATAIST-----ELHG-FADSSKQ-AYG-ACLYTR--ILQS-DG------TFVM-K-- LICS---------------------------KSRI-LPK--S--SNR------------- ---SKP--------------------------ITTPRSELLAAV-LLA-RLADKFLSS-- -TE-------TKF---AAV---YL---------WS------------------------- ---------------------------------------LPHHCV-------IKPS-STT TKL-RVVFDGSAKSS-SG---ISINDALIPGPIVQ--NDLVAILLNFR---CFRY--VVT LDVPKMFRQIGVQSA--DRKYQR-----I------VWRDS---S-DQ---------PL-K NFELQTVTYGLASSPFLATMA-LKQL------------A----IDH-SEEY--P-LAAAA I-EKC--FYMDDA-LTGAQ-T---LEEACKLQQELV-QL-LRRG-------CFDAH-KWC SNSD-VI-LEDVPDELKGD----------------------------------------- ---------------------------G-------------------------------- -----VNV---------------------------------------------------- ----------------------------------------------------------QP APAFTRTGIDFAGPFS-------------------------------------------- ----------------------------IKSTTEARRP---MIT------KG-YVC---L -FVCMS--TRAIHVELVSNLSSEAF-----LAALRRF-VSRR-GLTSTIFSDNATNFVGA DGELE-E-------LRRLFECE-QH------------------QKQLN---QFCSSKGIE ----WRFIPPRSPHFGGMWEAGVKSIKHHLKRIVG--T-----RRL----TFEEL----- --YTT-----LTQIEAVLNSRP--------LTQ------------A-------------- ----------------------SD--------DPS--D-------L-------------- ----------- >562/1-547 ---PTKRDVLRTVMAIYDPMGIIANFLMYVKILMQE-IWRA-G----------L------ -GWDD-V-LSG--RLAEKWSVWVAVLPTIS---Q-VRVP--RCY--R------------- -QFTSV---NAKI-QLHV-FCDASEN-GMA-AVAFFR--FND--GG------IIEC-S-- LVGA---------------------------KTRV-API--K-F---------------- --------------------------------VSIPRLELQAAV-IGA-RFAAAIIAQ-- -H------R-IAI---ERI---FY---------WT------------------------- -----------------------------------RDWFLPIFPV-------FNAN-K-P GKV-RVVFDAAAK-V-QG---VSLNTYLLNGPDLL--AGLLSVLYKFR---EHRV--AIV GDIKEMFFQVRMKPD--DQRSQM-----I------LWNEN---DFTG---------SEPD VYAVAVMTFGAACSPSTAQFI-KNLN------------A----DRF-ADKY--S-RAVKC I-KEE--HYVDDL-LASAE-T---DEEIITLAEQVR-HI-HAEG-------GFEIR-NWL SNSH-RV-TSHL--QR---EASP---EDKINM-----------------------CSD-D RT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY QKPFSFTGVDYFGPVT-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -FTCLT--TRGIHLEAAHSLTTSSC-----ILAIRRF-IARR-GQPLEFISDNGTNFVGA SRELA-E-------AWEAIDKQ-R----------------------LA---EEFTTPRLA ----WKFIPPGGPHFGGCWERLVRSVKKAMSEIRM------S-RLP----TDEVL----- --TTA-----LTEIEAMLNSRP--------LTQ------------V-------------- ----------------------PL-------------DS--------------------- ----------- >563/1-550 ----TKRVILSEISRIFDPLGFLGPVLTAAKLIMRE-LWLL-D----------L------ -HWDD-A-LPQ--DLVELWMEFRDQLQSLN---G-LEIP--RCX--L------------- --NRDCIGI-----ELHG-FADASDL-AFG-ACLYAR--SVFR-DG------KAEM-R-- LICS---------------------------KSRI-LPK--K--QGT------------- ---KKE--------------------------VTTPRAELQAAL-LLA-RLAVKLIGA-- -ME-------IQF---ASV---VL---------WS------------------------- ------------------------------NENPTDAFYLPHHCV-------LKPT-SST TKL-RVVFDGSAESS-TG---VSVNQTQMVGPTVQ--NDLVSIHLRFR---TFQY--AIS ADIPKMYRQVRMDDD-----FLR-----V------FWRSN---R-DD---------PL-R VYALKTVTYGLASSPFLATMA-LRQL------------A----DEE-EHRY--P-LAAST V-KKS--FYIDDM-LAGAN-S---LEEAAELLRQVT-GL-LHDG-------GFDIH-KVC SNSK-EL-LDMVPENKREK----------------------------------------- ------------------------------------------------------------ ---------------------------------------------LGVID---------- ----------------------------------------------------------QA AYPFCNVGIDFAGPFT-------------------------------------------- ----------------------------LRAAVSTKKS---LIT------KG-YVC---V -FVCMA--TRAIHLEAASNLSTDAF-----LASLQRF-VSRR-GLPTKIFSDNATNFVGA NNELT-K-------LADLFQTE-MH------------------QKKLN---GFCVQRNIE ----WSFIPPRSPHFGGIWEAGVKSAKFHLRPILA--D-----HKL----SYEEL----- --TTV-----LAQIEATLNSRP--------LVP------------S-------------- ----------------------SD--------DPN--D-------M-------------- ----------- >564/1-576 -----KRVVLSDAARIFDPLGLIGPIVVVAKMFLQD-LWKE-Q----------V------ -GWDE-S-LSE--VLQNRWMEYRRNLISLE---S-ITVP--RWV--G------------- --CNPK-CV--EV-EVHG-FSDASEK-AYG-TCFYMR--SVWD-DD------TVAV-F-- LLTS---------------------------KSKV-APL--E-DLKR------------- ---KRKK-------------------------QSIPRLELSAAL-LMS-HLYEKIKGN-- -F-P----S---N---TKA---YF---------WT------------------------- -------------------------------------YYMPHHAV-------IKPD-STT TKL-RVVFDASCVTS-TG---VSLNDALMVGPVVQ--DELYDINIRFR---LHMF--VVV ADVAKMYRMVKVDPA--DQQYQM-----I------VWRDS---S-DE---------PI-Q SYKLTTVTYGTASAPYLATKC-LQML------------S----EDG-ESTH--P-IGSRV V-KKD--FYVDDM-LSGAD-S---IEEAKQLVAETS-DL-TSSA-------GFILR-KWR SNHE-EV-LRGLPAHQRDDGG--I-V-ELE---------------------------S-- SSAAI-----------------KT--LG-------------------------------- -----LLWDSNDDCYRFKVPTWN--------------------------F---------- ----------------------------------------------------------TP APAFLKVGVDYCGPFS-------------------------------------------- ----------------------------MSYP--GRKA---RPI------KC-FVV---V -FVCLV--TKAIHLEIALDLTTQAF-----VAALRRF-VARR-SKPQLIMCDNAKNFVGA KREVD-E-------LAKLFQSQ-QF------------------QEAVV---RDSCNDSIE ----FKFIPARSPNFGGLWEAAVKSFKYHLKRTIG--L-----RIV----THDEF----- --VTV-----LVQIEACLNSRP--------LTP------------L-------------- ----------------------SS--------DPN--D-------L-------------- ----------- >565/1-546 ----TKRNVLSEVQKIFDPLGVISPIVLHGKLIMQE-IW-SAK----------L------ -DWDQ-K-LPE--KIEKEWIWFCKQVDAIQ---H-VSFP--RHV--P------------- --SKGTL-V-----ELHG-FSDAAKR-AYG-AVIYVR--TVCA-EG-------VYV-S-- LLCS---------------------------KSRI-APC--S-EKAN------------- ---KED--------------------------ITIPRMELRAAT-LLV-ELMAKVREA-- -LS-------VQI---HGI---YY---------WT------------------------- ------------------------------LSSDNPVFYFPHHPV-------LRPD-NIT TKL-RTVFNGSAHTS-TG---LSLNDVLMSGPTIQ--QDLFNILLRFR---CHRY--AMT ADIKKMFRQILIHDS--DRQLQL-----I------LWRFS---P-EE---------AV-V TYRLNTVTYGTCSAPFAAARC-LRQL------------S----LEY-EDQY--P-HTSQV I-IMD--FYMDDV-LTGDD-E---LEKLIRTKEELS-TV-LQSA-------GFELH-KWK ANDP-SI----VPEDES------------------------------------------- -TSAV-----------------KI--LG-------------------------------- -----MQW---------------------------------------------------- ----------------------------------------------------------NP GRPFETCGIDFGGPIT-------------------------------------------- ----------------------------AKEV--FVRT---QKTH-----KI-YFA---L -FICLR--TRAVHLELVSGLSTTDF-----IAALRRF-AGQR-GWAKTIYCDNATNFVGS KNEIK-A-------LAESFNYQ-VA-------------------PDIQ---EFCKTQGVE ----WKFIPPRSPAFGGIWEAGIKSVKQHIRRVLG--P-----TIP----TYEEM----- --LTL-----LKQIEGCLNSRP--------ISP------------M-------------- ----------------------SS------------------------------------ ----------- >566/1-585 ---PTKRRMLGFVMKIYDPLGLVGSLVVQGKILLQD-VWRA-K----------V------ -DWDE-Q-IPE--VLFARWKQWMQILKEVN---E-VRIP--RCY--F------------- -PGYSPA-CYDTL-ELHI-FVDGSAQ-AYS-SAAYFR--VRD--RG------QIRC-A-- LVAS---------------------------KTKV-APL--Q-L---------------- --------------------------------VSVPRLELQAAV-IGA-RLRKSIEDG-- -H------S-IKV---TRT---YF---------WS------------------------- ---------------K---------------FDPRRTWYLPLGVV-------LNPN-K-P GKI-RVIWDAAAK-V-GG---VSLNTMLLKGPDFL--TPQLSVTFKFR---EREV--AFS GDIQEMFLQVGIRKE--DRSALL-----F------VYRNS---P-RE---------P-MV TMASDVAIFGATCSPAQSQFV-KNRN------------A----TEN-EEEY--P-RAAAA I-KNK--HYVDDY-LDSVD-T---EEEAVELALDVA-KV-HQKA-------GFHIR-NWV SNRS-SV-LEAI--GE-----VNPVTVKNLSM-----------------------N-SQS GF--E-----------------RV--LG-------------------------------- -----MSWLPCEDVFCFTINVQDNLDAEIAPTKRRMLGFVM------------------- ----------------------------------------------------------PF VRPFTFVGIDYFGPYL-------------------------------------------- ----------------------------VK--VG-R-----C-AV-----KR-WVA---I -FTCLT--VRAIHMEVVHSLSTDSC-----KKAVRRF-IARR-GAPQEVYTDNGTNFIGA SKELN-D-E------LRE-IYN-T----------------------LG---SSFTDTNTQ ----WRFNPPAAPHMGGCWERMVRSVKTAIGT-LP--E---S-RKL----DDESF----- --ITL-----LAEAEHMVNSRP--------LTF------------L-------------- ----------------------PL-------------DS--------------------- ----------- >567/1-559 ---ATKRILLSNTMKIYDPLGLIANYVVESKILMQD-IWRQ-G----------L------ -DWDD-K-LPA--ELQRRWQEWVVRMKEVE---T-INIP--RCY--S------------- -SVS-EV---LRR-ELHV-FVDASEK-AFA-AVAYLR--TTHK-KG-------VDI-S-- LVAA---------------------------KSRV-APT--K-P---------------- --------------------------------LSIPRLELQAAV-LGA-RLAETVLKE-- -M------R-MEL---DGA---LF---------WT------------------------- -------------------------------------NYIPHFAV-------INYN-KPK PKP-RLVFDAAAK-N-NG---ISLNSQLLSGPDAV--ASLFGILIRFR---EGRV--GIS GDIKEMFHQVGIRQE--DRCAQR-----F------LYRS----N-PN---------DKPQ IFEMKVMTFGATCSPACAQFV-KNEN------------A----ALF-QTRY--P-EAAIA I-VRN--HYVDDY-LDSFD-S---DELAIKRTKEVI-NI-HDEA-------KFYIR-NFL SNSV-KV-LESL--------PKERVSDSNL-M-----------------------KICES DNTYD-----------------KI--LG-------------------------------- -----QWWDRERDSLKYIIKGL-------------------------------------- ----------------------------------------------------------PF IKPFTHTGADYFGPLT-------------------------------------------- ----------------------------VS--IG-R-----R-TE-----KR-WCA---L -FTCLT--TRAVHLELANDLSTSSF-----LICLRSM-QHRR-GKVGYLYCDNGTNFVGA CREMG-I-------LQEKC-----------------------------------ATEGIE ----FHFNPPASPHFGGAWERMVQEVKSLLSIS----H---E-PYP-----EHIL----- --RSA-----LIEIEFMINNRP--------LTH------------I-------------- ----------------------PL-------------DHEDDEPLTPSHF---------- ----------- >568/1-539 ---MTRRGVLSTVASVYDPLGFVAPFLLVGKQILQV-LCKD-K----------V------ -SWDE-D-LPE--HILPQWESWLRDLPHLA---D-LKIP--RSY--L------------- -SSNFDR--PVSY-ELHS-FSDASLS-GYG-ACSYLR--ATSE-TG------QISC-S-- LVIG---------------------------KARV-TPT--K-Q---------------- --------------------------------TTIPRLELSAAV-TSV-RNGNIVKRE-- -L------E-IED---LQE---YY---------WT------------------------- ---------------E---------------LDNKSAWYIPHHGV-------YHPH-K-P GKI-RVVFDCSAR-F-QE---ASLNDHLLTGPDLT--NTLVGVLCRFR---KGPI--AIM CDIERMFHQFHVTKE--HQDYLR-----F------LWWDN---GNLD---------SKPS VYRMRVHLFGAASSPGCSNFG-LKYL------------A----SQG-HGSF--SEEAIKF I-QRS--FYVDDG-LTSVS-T---SAEAIHLVDEAR-AL-CKTG-------NLRLH-KFV SNDM-EV-IATI------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ET SPPFTCCGIDCFGPFI-------------------------------------------- ----------------------------VK--EG-R-----K-EL-----KR-YGL---L -FTCLC--SRAVHIETLDDLTTDAF-----INALRVF-VAIR-GPVRQIRCDQGTNFMGA RREFS-D-------LLRGMDQE-R----------------------VR---AI----GCE ----FVVNVPSASHMGGVWERQIRTIRSILNAMLD--G---SACRL----DSTTL----- --RTF-----LYETMAIINSRP--------LSV------------E-------------- ----------------------HL--------H----DPTGPEPLTPNHI---------- ----------- >569/1-592 ---PTMRNLYKTLASQFDPLGFIIPFTTRAKTLIQD-LWKQ-N----------L------ -SWDD-PIEPL--YLRDKWSTWVAELSHIT---T-VQFA--RPY--A------------- -PAMSDT-PSTIR-ELHV-FCDASER-AYG-SVAYLQ--IRNE-E-------KVHV-S-- FVLA---------------------------RSRV-APR--K-C---------------- --------------------------------LSMPRLELCAAH-SGA-QMSKVIQAE-- -L------T-IPI---HQV---TH---------WT------------------------- ---------------A---------------NHSTESWFIPHHLV-------HHN----- GKD-RIVFNCSFQ-Y-NG---QSLNEQLLPGPTLG--PSLLGVILRFR---QHAV--AVS GDIKGMFHQVRLLPG--DRPVLR-----F------IW-RN---MNRE---------AVPD IYEWQVLPFGTTCSPCCAIYA-LQCH------------S----QEN-RES---RPDLADI V-ETS--FYVDNC-LHSTP-N---QDEAKAIIDGLR-ES-LLKG-------GFEIR-QWA CNVP-SV-LKHL-------PSEAISASSECWL-----------------------SQSSS -YLQE-----------------LT--LG-------------------------------- -----LQWNCIDDTLGYKTRIAEPIQPTMRNLYKTLASQFDPLGFI-------------I ----------------------------------------------------------LF KPPFYSTGIDCFGPFH-------------------------------------------- ----------------------------IK--IG-R-----R-RE-----KR-WGI---L -FKCLT--TRCLHLDLLEHLDTDAF-----LLSLRRF-ISRR-GKPAEILCDNGTNFVGG DHELR-D-------SFKQMAPK------------------------LQ---TQLAQQQIQ ----FRFNPPNAPHFGGTWEREVKSVKAALQVILR--E---Q--CV----PESVL----- --QTL-----LVEVEGILNSKP--------LGY------------V-------------- ----------------------SS-------------DI--------------------- ----------- >57/1-571 ----TKREILSTIARLFDPLGLIAPVVISAKIILKE-ITLA-KQYREDGSSTSL------ -DWDE-P-VPN--TIAVKWQQFRQQLMKVK---T-IKIP--RSV---------------- ---KFTPLFSSEI-QLHT-FCDGSSS-AYA-AAVYAR--TQQS-DG------TFYT-T-- LIVA---------------------------KSKI-SPT--K-P---------------- --------------------------------LTIPRTELCGAV-LAT-KLTKWVLEN-- -N------R-WTNAH-IST---FY---------WT------------------------- -----------------------------------ASCVLPHHAV-------FKEE-SLT TKQ-RIVFDASARTS-NG---RSLNDVLCVGPTLQ--NDLPAVLLNWR---QYQF--VFT ADIQRMYRCINVHPD--DTQYQR-----I------LWR-A---A-DG---------VI-K QHCLTTVTFGTASAPYTAIRV-IHQI------------A----EDT-QTKY--P-MASNV L-KNE--IYVDDI-LSGDH-S---QEAAIRKSLQTM-LA-LKSS-------GMELR-KWA SNDQ-DL-MATIPLEHRCKQT----SLSWD------------------------------ NADTI-----------------KT--LG-------------------------------- -----MYW---------------------------------------------------- ----------------------------------------------------------PP TRPFITTGVDYTGAIE-------------------------------------------- ----------------------------LQAA--RVRG---STTY-----KG-YVA---I -FICLA--TKAVHLEAVTGLSTEHF-----LQAFTRF-TGRR-GQVQHMYSDNGTNFVGA STSLNQ-----------------PI--------------------TCK---AALNESTCQ HGTRWHFTPPYSPNFGGIWEANVKAMKHHLKRIVG--S-----HKQ----TYEEL----- --TTV-----LIRIEACLNSRP--------LCP------------L-------------- ----------------------TA--------DPD--D-------LEVLTPAHF------ ----------- >570/1-601 ---PTKRGMLSIISSVYDPLGFLAPLILPAKLLLQE-LCRT-K----------C------ -DWDD-P-IPP--AFQQKWNKWLTDLEKVA---Y-FKIP--RCV--K------------- -PEGFGR--TVSA-QLHH-FADASEN-GYG-TATYLR--MQNM-DE------RVHV-A-- FLFG---------------------------KARV-SPL--K-P---------------- --------------------------------VTIPRLELTAAV-VAV-RVDKMLQSE-- -L------Q-LPL---KKT---CF---------WT------------------------- ---------------E---------------TPTGKVWYIPHLGV-------YHPR-K-- GKL-RVVFDCGAE-Y-KG---ISLNSQLLQGPNLT--SSLVGVLVRFR---EEQV--AIM ADIKATFHQVKVAEE--HRDYLR-----F------LWGPQ---GTLE---------QDLV EHRMTVHLFGAVSSPSVACLA-LRKT------------A----EDN-QANF--STEVIET V-NRN--FYMDDL-LKSLP-S---EADAVTMAKNLT-TI-CGRE-------GFTLT-QWI SNSR-RV-LQSL-------PEDLRSKNLHELD-----------------------LDRDK -LPLD-----------------RA--LG-------------------------------- -----LQWCIETDTFKFKLKVKEKPPTKRGMLSIISSVYDPLGFLAPLI----------- ----------------------------------------------------------PD LPPFTNVGVDYFGPVD-------------------------------------------- ----------------------------VK--RG-R-----S-IM-----KR-YGV---V -FTCMT--SRAVHLEVAYSLDTDSC-----INALRRF-ICRR-GQVSHLRSDNGTNFVGA EKELR-K-------ALASLNHN-R----------------------IE---KVMSKKGIK ----WSFNPPAGSHHGGAWERMIRMIRKILCSVLR--Q---Q--TL----DDEGF----- --HTV-----LCEAEAMLNDRP--------ITR------------L-------------- ----------------------SE-------------D--------PNDL---------- ----------- >571/1-532 ---YTRRGILSVVGSVYDPLGFLAPFVLPAKLIMQE-LCRK-H----------L------ -GWDE-N-IPQ--TISQQWTQWLTDLNNMT---E-LKVD--RCM--K------------- -PTNFGQ--IGHA-QLHH-FSDASES-GYG-TVSYLR--LENN-EK------EVHI-A-- FMIG---------------------------KARV-APL--K-Q---------------- --------------------------------VTIPRLELTAAV-LAV-KVDIMLRRE-- -L------Q-LXL---NKS---TF---------WT------------------------- ---------------N---------------RTDGKLWYIPHHGV-------YHPR-R-- GTL-RVVFDCGAG-F-KG---TSLNEQLLQGPDLT--NSLIGVLLRFR---QEPV--ALM ADIKAMFHQVKVSDN--HIDYLR-----F------LWWPD---GDVQ---------QDLV EYRMKVHLFGAVSSPSCANFA-LRKT------------A----EDN-LTHF--PAEVIDT V-KNN--FYVDDC-LKSMS-T---EQGAVLMVRDLT-TL-CQKG-------GFILS-KWI SNSR-KV-LASI-------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PD KPPFTDVGVDYFGPIA-------------------------------------------- ----------------------------IK--RG-R-----S-LV-----KR-YGV---I -FTCMX--SRAVHLEVAYTLDTDSC-----IHTLRRF-ICRR-GQVQSLRSDNATNFVGA ERELR-E-------ALNALNQD-K----------------------IQ---TAMLQKGIK ----WHFNPPAGSHHGGVWERLIRMVRNVLRSVLS--Q---Q--VL----DDEGL----- --QTL-----ICEVEAILNDRP--------ITK------------L-------------- ----------------------SE-------------D--------PMDL---------- ----------- >572/1-582 ---PTMLHLYRVLASQYDPLGYILPYTTRAKIIVQQ-LWGK-T----------R------ -DWDD-PNIPH--NLLEAWLSWEGELPALS---T-ITLP--RCF--T------------- -RS-VDP-TSAIH-DLHI-FCDASEQ-SYG-AVAYMR--TEDD-Q-------QVNV-S-- FLVA---------------------------RSRI-APK--K-R---------------- --------------------------------LSIPRLELCAAL-IGA-QLANLLQTE-- -L------A-LHI---RKT---TL---------WT------------------------- -------------------------------------GTYPTTLX-------ITM----- VKS-ALYLNVTFP-T-E----ISVXIQLLPGPILG--PSLLGVLLHFR---QYKT--AIN GDIKSMFHQVRLLPQ--DKPLLRNFFFFL------LW-RD---LDCK---------APPT VYEWQVLPFGTTSSPCCAIYI-LQKI------------I----ED--AQA---AECISHS I-HNC--FYVDNC-LQSLP-T---LEEAKDLLQNLR-TI-LSSG-------GFEIR-KWA SNDP-RV-ISDL-------PPESRSEQTELWL-----------------------SHHPS LDPSE-----------------ST--LG-------------------------------- -----LLWNCHKDILRYRHRAIEPTTPTMLHLYRVLASQYDPLGYIL------------- ----------------------------------------------------------LC KPPFYSTGVDCFGPYT-------------------------------------------- ----------------------------VK--IG-R-----R-AE-----KR-WGI---I -FKCLT--TRYIHLDLLCHMNTDSF-----LMALRRF-VARR-GKPAELLSDR------G NKKLL-E-------AYHSVTND------------------------LQ---ATLAKQRST ----FKFNPPHAPHFGGTWEREIRSIKIALESTLG--A---Q--TV----SEEVL----- --RTV-----MIEIEGILNSKP--------LGY------------V-------------- ----------------------SS-------------DV--------------------- ----------- >573/1-519 ---PTKREVLRVVMSLFDPLGLIAFFLVHGKILMQD-IWSS-R----------A------ -HWDD-Q-INE--DLNLRWIEWSSLLPQLN---T-VQIP--RCY--F------------- -PKAEAD-VYSTL-QVHV-FVDASEK-AYS-CAVYFR--VLG--PD------GPLV-S-- LVGA---------------------------KSKV-APL--K-M---------------- --------------------------------LTIPRLELQAAV-LGT-RLLNSVISM-- -H------G-IPV---SQR---FL---------WS------------------------- -------------------------------------WYLPLGVH-------QNPK-K-P NKV-RLTWDGKAT-V-QG---VSLNSALLKGPDML--SSLPGVLSHFR---LFRY--ALT GDIKEMFHRIRIREE--DRQFQR-----F------LWRND---V-SQ---------D-PV VYVMDVATFGSTCSPCSAQYV-KNLN------------A----SEF-SGEY--P-RAAYA I-NHY--HYVDDY-LDSYG-T---REEAIKVGKEVK-MI-HSKG-------GFELR-NFL SNDA-EI-AARV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY VRPFTFVGVDYFGPVF-------------------------------------------- ----------------------------VK--TG-R-----S-NA-----KR-WIA---L -FTCLT--IRAVHMEVVHSLTTEFC-----VMAVRRF-VSRR-GSPAEIYSDNGTNFHGA ENQLK-R-E------IEE-RNH-R----------------------LA---TVFTNSCTR ----WMFNPPGAPHMGGVWERMVRSVKATIGTILE--T---Q-RRP----DDEVL----- --ETV-----ILEAEAMINSRP--------LTY------------I-------------- ----------------------PL-------------DF--------------------- ----------- >574/1-568 ---PTKRKVLSDISKLFDPLGFAGPVVMTGKLLMQE-LWKQ-K----------Q------ -TWDG-A-LDA--KQEKLWYEYRRQLQEME---T-IKIS--RCV--L------------- -PLS-N-TI--SV-DLLG-FSDASEK-GYG-ACLYLR--SRNI-QG------QISI-R-- LLCS---------------------------KSHV-APL-------K------------- ---ANR--------------------------ATIPRLELCGAV-LLA-QLVDQVTRS-- -L-P----V-D-I---DQI---KL---------WS------------------------- ------------------------------E-----CYFIPHHAI-------QRPD-SST TKV-RVVFDASAKSS-NG---VSLNDLLLVGPTLQ--PHLVNILLAFR---VHKV--VAT TDVSKMFRQISIREE--DRRFLH-----I------LWRSS---P-EE---------EI-S VYRLTTVTYGTACAPFQATRT-LLQI------------C----DDE-AEKF--P-LAAQF G-KKS--VYVDDA-LFGAE-T---VEEVQKMRKQFE-AM-LATA-------GLELH-KWC SNRE-EV-LADLPTEKLEQKV------------------------------------LFS EEGRT-----------------KT--LG-------------------------------- -----LTWQPTQDIFSFQI----------------------------------------- ----------------------------------------------------------EA EYPFYRVGIDLCGPIA-------------------------------------------- ----------------------------IKQR--NKRS---TVEH-----KG-WIA---L -FVCLE--TKAIHLEIVSELSTGAF-----MAAFDRF-ISRR-GKPATVWTDNGTNFVGT SNILK-Q-------WKEFFESS-ET------------------QEGIQ---Q-ASDSEIE ----WCFNPPEAPHFGGIWEANIRQTKSLLIKYTA--G-----ATL----CFEEL----- --STV-----LARIEAVLNSRP--------ITS------------L-------------- ----------------------SD--------DPE--D-------F-------------- ----------- >575/1-560 ---PTKRSILSEIAKLFDPLGLIAPVVVRAKILMQE-LWLL-S----------C------ -DWDD-P-VPD--PVKSKWESYHQDLSKIS---Q-HRVE--RYA--F------------- --LP-N-SN---I-QLHT-FADASQS-AYG-ACTYVR--CKDA-QG------TVRI-Q-- LLAS---------------------------KSRV-APL-------K------------- ---R----------------------------LTIARLELCAAV-VAA-HLHDRIKKA-- -I-N----V-D-V---SSS---YF---------WS------------------------- ------------------------------EEENSPAYYLPHHPV-------IKEA-STT TKV-RVVFDGSAKTS-TG---FSLNEALCVGPVVQ--DDLLDIILRFR---TFPV--ALV GDIAKMYRQVLIHPD--DTPLQR-----I------LWRFS---Q-QT---------AV-Q IFELLTVTYGLAPSSFLATRT-LQQL------------A----EDE-GEAF--P-KAAPA L-KKS--FYVDDF-IGGAQ-S---VQEAIHLRSELS-CL-LEKG-------GFELR-KWT SNRL-EV-LQGLNDAQVGTQS--S-L-QFV---------------------------P-- -HETI-----------------KA--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------TP SRPFDVTGVDYAGPLY-------------------------------------------- ----------------------------LRPI--HKRA---SPA------KA-YLC---L -FICFS--TKAVHLELVSDLSTQGF-----LNSLRRF-IARR-GRPSHIHSDNGKNFEGA KNELT-E-------LFHRFHDV-TQ------------------QDTIA---SACADEGIN ----WHLMPPKAPHFGGLWEAAIKVAKRHLYRQLG--S-----TRL----SFEDM----- --CTV-----LIQIEAAMNSRP--------LLP------------M-------------- ----------------------TE--------DPN--D-------L-------------- ----------- >576/1-546 ---PTKREVLRTLMMIFDPLGLIGHLLMFLKVVLQE-IWRT-S----------V------ -SWDD-P-IEE--AQFERWLQWLKVLPEVE---T-VEVP--RCY--R------------- -STVSLE-SSTEV-QMHI-FVDASEN-GFA-AVVYLR--FQQ--GD------IIET-A-- LVGS---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQACV-IGA-RFANTLQKS-- -L------T-VKV---NRR---FF---------WT------------------------- -----------------------------------REWYLPVFPV-------INPN-K-P GKI-RLVWDAAAS-V-YG---TSLNSLLLKGPDLL--TSLLTVLVQFR---EFRI--GIC GDIREMYLQILLKQE--VRLR-------F------FWKDN---K-HD---------LHPQ VFEMLVLPFGVSCAPSIAQHV-KNVN------------A----KRF-EHEH--P-TAVRA I-VDQ--HYVDDM-LASVE-T---EEEAVSLVNDVK-RI-HAAA-------GFEMR-NWI SNCS-TI-MEAL--DE---PRTE---VKNLNL-----------------------AEA-G VT--E-----------------KV--LG-------------------------------- -----LWW---------------------------------------------------- ----------------------------------------------------------AF SRPFTHMGVDYFGPLL-------------------------------------------- ----------------------------VS--TG-R-----R-SE-----KR-WVL---L -ATCLT--TRAIHLQIVHSMTTNSC-----IMAIRNV-MARR-GTPAVIYSDRGTNFQGA CSELE-T-------AMANLDND-K----------------------LA---KEFTTSRTS ----WKFIPPASPHMGGAWERLVRTVKQNLDRIKP------S-ESM----SYEVL----- --ENM-----LTEVENIINSRP--------LTS------------I-------------- ----------------------PI-------------DS--------------------- ----------- >577/1-544 ---PTKREILRTLMAVFDPLGLISNVLIYLKVLFQE-VWRS-G----------I------ -GWDD-V-IPE--HLHEKWEQWLEILPAVQ---N-IRIP--RCY--R------------- -LTTQLS-AQTNI-QLHT-FVDASLS-GYA-AVVYLR--FEQ--GN------TVEC-A-- IVGA---------------------------KTRV-APL--K-F---------------- --------------------------------VSIPRLELQAAV-IGV-RLADTITRA-- -L------S-IKV---HQR---CF---------WS------------------------- -----------------------------------RVWYLPLFPV-------FNPN-K-P GKV-RVVWDAAAK-T-NG---VSLNSLLLKGPDLL--TPLDYVLYRFR---EFRV--GLS GDVREMYLQMLMAEK--DQHCLR-----V------LWNDD---S-AG---------D-PN TYVTQVMPFGTNCSPTCAQYV-KNLN------------A----KKY-EEQY--P-EAANA I-IKQ--HYVDDM-LVSVE-T---EEEAIKLAKEVK-FV-HSQA-------GFDMR-NWI SNSS-AV-VEAM--ME---DTPQ---DKNLNI-----------------------GAE-L ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF TRPFSFVGIDYFGPIT-------------------------------------------- ----------------------------VA--IG-R-----R-TE-----KR-WGV---L -ITCLT--MRAVHIEVAHSLNVTSC-----VMALRNF-MARR-GVPIRIHSDRGTNFTAA KKELA-AANDDLRAALKEMDQD-K----------------------II---AEIVSSETE ----WTFLPPASPHMGGAWERLIQTVKKNLRAIQP------G-RNP----SEEIL----- --RNM-----LAEVENVVNSHP--------LTY------------V-------------- ----------------------PV-------------ED--------------------- ----------- >578/1-523 ---PTKRQILKCVMSLFDPLGLLACHLVHGKVLMQD-VWRT-G----------I------ -SWDE-P-VXD--EIMRHWERWIRLFSNVK---N-LRLP--RCY--F------------- -QNASSA-LYXSL-QVHV-FVDASEV-AYS-AAVYFR--IIGA-DG------IVQC-S-- LVAA---------------------------KTKV-APL--K-Y---------------- --------------------------------VTIPRLELMAAT-LGT-TLLSFVIDG-- -H------T-IQI---KKR---FL---------WS------------------------- -------------------------------------WYLPLGAV-------INPK-K-P EKV-RLIWDAAAK-V-NG---ISLNSVLLPGPDLL--TPLPAVLFRFR---QFPV--AVS SDIREMFHRILVTEA--DRHSQR-----F------LWRNC---P-DQ---------K-PQ IFLMDVITFGATSSPVSAQFV-KNKN------------A----LEF-VXRC--P-RAVEG I-LKS--HYVDDY-LDSFE-T---VGEAKSVSSEVR-AI-HLKG-------GFELH-NWS SNNK-EV-LEN------------------------------------------------- --------------------------LX-------------------------------- -----VAA---------------------------------------------------- ----------------------------------------------------------PF VRPFSFVGLDYFGPIP-------------------------------------------- ----------------------------VK--VG-R-----S-SM-----KR-WVA---L -FTCLT--IRAVHVEVAYELSTASC-----ISCITRF-VSRR-GAPLEIHSDNGRNFVGA ANVLR-D-Q------IKR-IEA-E----------------------VA---ATFTTINTK ----WVFIPPLAPHMGGSWERMVRAIKAALYNL-P--Q---E-RKM----DDEAL----- --QTM-----LTKAEAIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >579/1-562 ---PTMRNIYRVLASQYDPLGYILPYTTRAKILVQA-LWIN-K----------C------ -GWDE-CIGGD---MQDKWEQWTNELQYLS---R-ITIP--RCY--F------------- -PICPEP-NKPKL-ELHI-FCDASER-AYG-SVAYLR--LEGE-DG------RIYT-S-- FVMA---------------------------RSRV-APK--K-Q---------------- --------------------------------ISMPRLELCGAL-TGA-QLAKLLITE-- -L------T-LPI---NNT---IL---------WT------------------------- -----------------------------------ESWYIPHHLV-------HHN----- SKA-RVVFNCSYQ-F-HQ---DSLNDQLLPGPMLS--PSLLGVLLRFR---QYPV--AIS GDIRSMFHQVRLLPE--DHQLLR-----F------LW-RN---MEKE---------RSPD IYEWRVLPFGTTCSPCCAIYA-LQRH------------V----TDH-REG---NEEVVES V-LNS--FYVDNC-LQSFL-S---TNEAKQLIDKMR-AL-LAAG-------GFEIR-QWA SNYA-EV-ISHL-------PTEARSESCDLWL-----------------------TANKT -DXQE-----------------ST--LG-------------------------------- -----LSWHCISDKLSFRNR---------------------------------------- ---TI-----------------------------------------------------LH QPPFWSTGVDCFGPFT-------------------------------------------- ----------------------------IK--IG-R-----R-HE-----KR-WGI---I -FKCLT--TRCIHLDLLHSMDSDSF-----LMALRRF-IARR-GKPFEIISDQGTNFRGG SRELQ-E-------AFSALEPD------------------------IK---EKLSEQSIS ----FQFNPPHAPHFGGAWEREIRSIKSCLRVVLK--D---Q--IV----TEEVL----- --TTV-----LIEVEGILNSKP--------LGY------------V-------------- ----------------------SS-------------EI--------------------- ----------- >58/1-567 ----TKRSVHSDAACFFDPLGLVGPVVVQAKIFIQR-LWLL-K----------C------ -GWDD-P-LDE--SLQDLWKEYKQNMIALE---S-LSIP--RWL--G------------- --VSND-CA--DV-QLHG-FCDASEA-AYG-ACLYLR--CTAS-DG------TVTV-R-- LITS---------------------------KSRV-APL--E-NLQR------------- ---KKKK-------------------------ITIPRLELSSAL-LLS-HLYEKY-NQ-- -V-R----P---N---LAA---FF---------WT------------------------- ------------------------------QPTADPVYYLPHHAV-------LRPD-STT TKL-RVVFDASCKTS-TG---ISLNDALMVGPVVQ--NDLISTILRFR---HHRI--AVT ADVAKMYRMVRVPEQ--DQHLQR-----I------LWRDT---P-EE---------PV-K TFELLTVTYGTASAPYLATRC-LKKL------------G----EDS-VSTH--P-IASRV V-QED--FYVDDM-LSGAD-T---VNQTRKLMNEVI-EL-TNTV-------GFTLR-KWN SNSA-GL-LSKLPKHLRDERT--V-L-DLD---------------------------S-- SNATV-----------------KT--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------NP APPFMNVGVDYCGPFF-------------------------------------------- ----------------------------VNYP--NRRA---SPV------KC-YVA---I -FVCLV--VKAVHLELVMDLTSQAF-----LAALKRF-TARR-GRPKLIMCDNATTFVGA KRELT-E-------LHRLFHAQ-KF------------------QDRLI---KDTSSDGIE ----FRFIPPRTPNFGGLWEAQVKSFKGHFKKAIG--T-----KVL----KVDEM----- --LTA-----LAQIEAVLNSRP--------LTP------------I-------------- ----------------------SS--------DPN--D-------Y-------------- ----------- >580/1-569 ----TMRNVYRVLARQYDPLGFVLPYTTRAKLLVQS-MWDK-H----------R------ -NWDD-PLLPH--ELQQAWKEWEAELHLLP---H-LSLP--RSY--V------------- -PAHVDQ-AIVSR-QIHI-FSDASEK-AYG-SVSYMR--TEDV-KG------QVYL-S-- FLAA---------------------------RSRV-APR--R-Q---------------- --------------------------------HSIPRLELCGAL-TAA-QLAKMLERE-- -L------T-LKI---DEI---IL---------WS------------------------- ----------------------------------GESWYIPHHLV-------SHN----- GKN-RLVFNCSYQ-F-RG---MNLNDALLPGPTLG--ASLLGVLLRFR---EHGV--AVS GDIKAMFHQVQLLPE--DRALLR-----F------VW-RD----RRE---------DPPD TFEWQVLPFGTTCSPCCATYA-LHRH------------V----RDC-SDP---EDGVKDS V-ERC--FYVDNC-LQSLP-T---AAEAKRLVDRLR-EV-LSSG-------GFEIR-QWA CNVP-SA-ISHL-------PKDARSDSMERWL-----------------------SHDEN -GLSE-----------------ST--LG-------------------------------- -----LSWHWESDTLGYKSRPLDYGVLT-------------------------------M ----------------------------------------------------------LY KPAFYSTGVDCFGPFQ-------------------------------------------- ----------------------------IK--LG-R-----R-SE-----KR-WGI---I -YKCLT--TRAVHLDLIHRMDSDSF-----LMSLRRF-IARR-GTPAELYSDQGTNFKAG EKELR-E-------SFDSMAAE------------------------LQ---QLLAKQKIA ----FHFNPPAAPHFGGAWEREIRSVKSALYTVIG--A---Q--SI----SDEVL----- --HTV-----LLEVEAILNAKP--------LGY------------T-------------- ----------------------SS-------------NV--------------------- ----------- >581/1-534 ---ATRRGILSTIASIYDPLGFIAPILFNGKKILQE-ICKR-G----------A------ -GWDD-F-LSE--EVQLRWEQWKQDLINLQ---E-INIP--RTY--V------------- -PNDFGT--IVKV-ELHH-FSDASTS-GYG-QCSYLR--FCNE-DG------DVHC-A-- LVMG---------------------------RSRV-SPL--K-V---------------- --------------------------------VTIPRLELTAAV-ISV-EVSNVLKRE-- -L------D-YVD---VEE---LF---------WT------------------------- -------------------------------------WYLPHHGV-------ISPK-K-P NKL-RVVFDCSAR-F-NG---YSLNDHLLQGPDLI--NSLIGILMRFR---QHPV--ALM CDVEKMYHQFHVNES--DRDYLR-----F------LWWKD---GKFN---------QNPL EFRMKVHIFGAASSSGCANFG-LKHI------------A----NEN-SHLY--PLGS-EF V-LKN--FYVDDG-VTSVK-D---AEMAVKVVDEAR-KL-CAMG-------GLRLH-KFM SNDD-TV-LND------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------IP SPPFKYTGMDCFGPLF-------------------------------------------- ----------------------------VK--QG-R-----S-VC-----KR-YGL---I -LTCLC--SRSVHIEMLTDMSTDSF-----INALRCF-IAIR-GAVQQIRSDQGTNFVGA KNEFK-R-------ALEEIDAE-R----------------------LR---VFLSEXQCD ----FVMNAPHASHAGGVWERQIRTVKSVLNSILS--L---HSARL----NDSSL----- --RTF-----LYETMAIVNSRP--------LTV------------D-------------- ----------------------CL--------T----DPDSLRPITPNHL---------- ----------- >582/1-582 ---FSRRGVLSTVASIYDPLGFVAPFVLLGKQILQQ-MCRD-K----------S------ -DWDT-P-LSN--ELQSRWESWLTDLKDLA---H-VKID--RCY--L------------- -PADFQE--VQRY-ELHH-FSDASVA-GYG-VCTYLR--AVSR-SG------RIHC-S-- LVIA---------------------------KSRV-APT--K-V---------------- --------------------------------TTVPRLELSAAV-VAV-RISDMLKGE-- -L------E-LEN---VQE---FF---------WT------------------------- ---------------E---------------LDKSSTWYLPHHGV-------YHPQ-K-P GKI-RVVFDCSAK-F-KG---VSLNDHLLTGPELT--NTLIGVLCRFR---KGPV--AVM CDIERMFHQFRVRDE--DQDYLR-----F------LWWDN---GDFH---------LSPS VYRMRVHLFGAASSPACANFG-LKYI------------A----AQG-RGQF--SEATIRF I-ERN--FYVDDG-LISFH-S---EEEAIRLVHEAK-KL-CSTG-------KLRLH-KFV SNSP-QV-LESL-------PKEDCVETVRNQD-----------------------LALGE -QLIE-----------------RA--LG-------------------------------- -----VKWSVASDHFQFRVVVS-------------------------------------- ----------------------------------------------------------ET TPPFTYCGMDCFGPFY-------------------------------------------- ----------------------------IK--EG-R-----R-EL-----KR-YGL---L -FTCLC--SRAVHIELLDDLSTDAF-----LNSLRAF-IALR-GNVRQLQSDQGTNFVGA RREFL-E-------AVKEMDQE-C----------------------LK---QL----GCE ----FVMNPPSASHMGGAWERQIRTIRSVLNSILD--Q---SSRTL----DSSSL----- --RTY-----LYEVMAIVNSRP--------ITT------------Q-------------- ----------------------LL--------N----DPTGPQPLTPNLL---------- ----------- >583/1-532 ---PTRRGILSVVSSIYDPLGFLAPVVLPAKQLLRN-LCKD-K----------K------ -GWDE-E-IDD--DQNQKWSNWLMDLQQLS---E-FAVP--RCI--K------------- -PVNFGS--TKMA-QLHH-FADASEA-GYG-TVTYIM--IKNE-NG------ERHC-S-- FLMA---------------------------KSRV-APL--K-Q---------------- --------------------------------ITIPRMELTAAV-VAV-KIDKMMQQE-- -L------C-LNL---EKS---VF---------WT------------------------- ---------------N---------------RNDGRVWYIPHHGI-------YHPK-K-- HKF-RVVFDCNAA-Y-KG---TSLNKQLLQGPDLT--NSLLGVLIRFR---QEPV--ALM ADIESMFYRVKVPDK--DADLLR-----F------LWWPE---GDLE---------QPLV EYRMVVHLFGATSSPSCASYA-LKRT------------A----EDA-RHNV--PQELVDT V-LHN--FYVDDY-LNSVP-T---EDHAIVLTEQLR-NL-CSSG-------GFRLT-KWI SNSR-AV-LSCI-------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GD KPPFTNVGIDFFGPLE-------------------------------------------- ----------------------------IR--RG-R-----S-LV-----KR-YGV---I -FTCLA--VRAIHIEVAHSLDTDSC-----INALRRF-ICRR-GQVAVIRSDQGTNFISA DKELR-E-------AMAALNQN-K----------------------IQ---DAMSKKGID ----WIFNPPAASHHGGVWERQIRTVRKVLNSVLK--Q---Q--NL----DDEGL----- --QTV-----LCEVEAIVNDRP--------ITK------------S-------------- ----------------------SD-------------D--------PNDL---------- ----------- >585/1-531 ----TKRKILAQTASYYDVFGMLSGLLVRPKILLQR-LWQL-D----------L------ -DWDS-P-LDQGSELYSMMSKINRDLNEMD---G-IEIP--RCL--I------------- -PEPYRGARPLPIVSMHG-VSDASED-AMG-FAVWLR--WSHADSQ------EAHL-S-- FVCA---------------------------RSRV-TPL--K-Q---------------- --------------------------------TSMPRKELQALL-LLS-RLMITIRDA-- -L------R-------FSIVGWKM---------WT------------------------- -------------------------------------------------------D-SKT TPV-RVVYDGKAK-F-QG---RSLNDCLIKGENVN--SNLLEVALRFR---ENEV--GMI ADISKMFQAIKISPE--DARFHR-----F------VFRE----N-PN---------HPIQ VFELTTVTFGDKPSPTAAIIT-LRHV------------A----REH-APDD--DKIQ-KM I-VEQ--FYMDDL-NESVS-N---AEEALELKSKLT-ET-LKKG-------NFNLR-KWQ SNVK-KV-CDE-----------------------------------------------TE NTDTA-----------------TV--LG-------------------------------- -----TSW---------------------------------------------------- ----------------------------------------------------------PC SPPFKTTLVDYLGPVM-------------------------------------------- ----------------------------VK--LN-R-----NTTT-----KG-YGA---L -FTCAV--TRAVHLTVVQDLSTXAF-----LQALERF-VSIR-GAPAMMVSDNATCFRGA DNTIN-E-------LNLKLNQT-Q----------------------VR---EHCQRYKVE ----WKFGPPGGPHHQGAVERMVQEVKKAMRHLVK--A-----DRL----TFVEW----- --ETV-----FCKISGLINRRP--------LTA------------M-------------- -------------------SSSPL-------------DH--------------------- ----------- >586/1-546 ---QTRRGILSVVSSIYDPLGYASPFILKAKMILQE-LTRL-K----------L------ -AWDE-E-IPS--KEIERWNEWLQELPKMT---G-FQVN--RCI--K------------- -PHDFGK--VAEY-KLHH-FADASEK-AYG-VVSYLR--MKDV-EG------QVHC-S-- ILFA---------------------------RSRL-APL--K-R---------------- --------------------------------MTIPRLELMAAT-LSV-TIDSMIQRE-- -L------D-LPL---QES---VF---------WT------------------------- ---------------Q---------------PKDTPVWYLPHHPV-------LNPQ-K-P DKM-RIVFDCAAK-H-QG---VSLNDAVLQGPDLI--NNLMGVLLRFR---QQPV--ALM SDIEAMFHQVRVPPE--DRDVLR-----F------LWWKD---GDFN---------KEPL VYRMCVHLFGGTWSPSVCSHA-LRQT------------A----RNG-DGNG--KVEASKA I-LEN--FYVDDC-LVSVE-N---EETAVKLAADLM-VL-LSEG-------GFRLT-KWV SNNP-FV-LQSI-------PEEERAKDVRGLD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE KPPFSNVGVDCFGPYM-------------------------------------------- ----------------------------VR--QG-R-----S-SV-----KR-YGC---I -FTCLV--IRAIHIEVLHSLETDSF-----LNALQRF-ISRR-GQPEIIRSDNGTNFIGA ERELR-E-------GLKRWNQE-K----------------------IH---DNLLQQGID ----WKFNPPRASHMGGSWERQIRTTRKVLNAVMK--Q---Q--VL----NDEGL----- --TTL-----MCLVEAIINGRP--------LTI------------T-------------- ----------------------SD-------------D--------ARDA---------- ----------- >587/1-560 ----TRRGVLATVMSIYDPLGLLAPVVLRGKQILQE-LCRK-A----------V------ -DWDD-Q-LPD--EQRSSWEKWRADLHNLD---S-ISIQ--RCY--K------------- -PAHFGE--VKTT-QLHH-FSDASTT-GYG-ECTYLR--LTND-EG------KVHC-T-- LLMG---------------------------KARV-VPL--K-P---------------- --------------------------------ITVPRLELTAAV-VSV-RVSAFLQRE-- -F------V-PSD---TEE---FY---------WT------------------------- ---------------K---------------TADSPVWYIPHHGV-------I----Q-P NKL-RVVYDCSAQ-Y-KG---ESLNDYLLTGPDLT--NALVGVLCRFR---RDEI--AFS CDIKEMFHQFKVRED--HRDYLR-----Y------LWWKD---GDIL---------REPI ELRMTVHLFGASSSPGCSNFC-LKQT------------A----TDH-ADEF--GNDVKDF I-HRD--FYVDDG-LKSVP-S---TKDAIDLVSRTR-QL-CKKS-------GLHLH-KFI SNSR-EV-MESV-------PEPDRAKGVSKTD-----------------------L---- --------------------------MG-------------------------------- -----VDS---------------------------------------------------- ----------------------------------------------------------EP TPPFTYSCMDVFGPWV-------------------------------------------- ----------------------------IK--EG-R-----K-EL-----KR-YGL---L -FSCMA--SRAVHIETLNSMTTDSF-----INALRRF-LSIR-GPVRQLRSDRGTNFIGA EAELR-E-------G-SNTHQD-K----------------------IQ---EFLLRNDCD -YIHFKFNVPSASHMGGVWERQIRSIRRVLETLLY--E---AGQQL----DDESL----- --RTL-----MNEAAAIVNSRP--------LTV------------D-------------- ----------------------NL--------N----DPTHPEPLTPNHL---------- ----------- >591/1-560 ----TRRIVLSYIAQIYDPLGLVGPVISATKQYMQR-LWSL-S----------S-HNGKS FSWDQ-P-LPE--KLQHEWKEIHNTLNLLS---E-IKVP--RFA--S------------- --VA-G-AA--NL-QLHF-FSDASEK-AYG-ACVYMR--SEDF-QQ------QVSV-Q-- LLTS---------------------------KSKV-APL-------K------------- ---TR---------------------------HSIARLELCGAV-LST-QLYKKVIDS-- -L-K----A-K-----IEI---FF---------WV------------------------- -------------------------------------CYLPHHAV-------FKAA-STT TKT-RVVFDASCSTT-SG---HSLNDTLMIGPVVQ--EDLLSIILRFR---TKPI--ALV ADIEKMYRQIEVHPE--DQPLQR-----I------LWRNH---P-SD---------PI-S TFELRTVTYGTASAPYLATRT-LVQL------------S----KDE-GETF--P-LAKTV V-AED--FYVDDC-ISGAD-D---VQTALQVRQQTS-TM-LKSA-------GFPLR-KWA SNSP-EV-LANIPEAELGIQP--F-Y-DFT---------------------------D-- -SQSV-----------------TT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------SP SRPFSISGVDYCGPFY-------------------------------------------- ----------------------------LRAP--HRRA---SPS------KA-YIA---V -FVCFS--TKAVHLELVGDLSTAAF-----LAALKRF-VARR-GKVSEIHSDNATNYKGA ANELH-Q-------LYKLLKSD-TLS-----------------RKLIF---DWCANTDIT ----WKFIPPRAPHFGGLWEAAVKSTKNHLLKEVG--N-----TTV----SYEEM----- --LTL-----ITQVKMCMNSRP--------ITE------------L-------------- ----------------------TN--------DPS--D-------L-------------- ----------- >592/1-544 ----TKRGVLRLLMTLFDPHGLISNFLIHGKIIVQD-LWRG-G----------V------ -TWDE-P-IPQ--EIYAHWKRWVNQIPALQ---N-VQVP--RCY--F------------- -SSYNVE-DLETL-ELHV-FVDASES-AYA-CVAYFR--IIE--QG------KPRC-A-- FVCS---------------------------KAKV-APL--K-P---------------- --------------------------------LSIPRLELQAGV-IGS-RMASSIKDN-- -H------S-LSI---KRT---VY---------HS------------------------- -------------------------------------WYLPLGVV-------INPK-K-P GKV-RIIWDAAAK-V-NG---ISFNSMLLKGPDMM--TSLPSVLFRFR---ERKF--CIT ADIKEMYHQVKICSA--DRSSQR-----F------LYRSN---P-TD---------E-LQ TYIMDVATFGSTCSPCSALHV-KNLN------------A----EEW-RDVY--P-KAASA I-VDN--HYVDDY-LDSRD-T---EEELANLATDVR-TV-HAKA-------GFDLR-NWR SNSK-NV-LRRV--GQ-ESVN----TEKKIGE-----------------------D-KIN QT--E-----------------RV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PF ERPFSRVGVDYCXPFA-------------------------------------------- ----------------------------IK--VL-R-----S-KV-----KR-WVA---L -FTCLA--TRAVHLEVVASLSTESC-----KLAFRRF-IDRR-GAPAEIYTDNGTNFQGT CRELA-K-Q------LAR-VND-G----------------------LA---ETFTDANTK ----WFFIPPASPHMGGVWERLVRSVKAAMAG-LR--H---L-RTP----TEEVF----- --QTL-----CTEAESMMNCRP--------LTY------------I-------------- ----------------------PL-------------ET--------------------- ----------- >595/1-536 ---PSKRIVLSIVMSLFDPLGLLTLFTIHGKVLIQD-LWRT-G----------C------ -DWDE-E-IND--ESFEKWQRWTALLPEVE---Q-VKIP--RHY--F------------- -EGGVSL-DYDSL-ELHV-FVDASEV-AYG-CVAYF------------------------ LVQA---------------------------RSKV-APL--R-Q---------------- --------------------------------YSIPRLELMAAV-LGA-KLAETIRAN-- -L------S-LSV---KRV---HF---------WT------------------------- -------------------------------------WYLPLNVV-------VNPK-K-P GKV-RLIWDAAAA-V-GG---ISLNSKLLKGPDFL--TTLPSVVCKFR---QYRI--GFG GDIREMFHQLQIRPE--DKQALR-----F------MYGG--------------------R IYVMDCAIFGATCSPSQALYV-KDRN------------A----KEF-VDRY--P-AAVDA I-VNR--HYVDDY-FDSTE-T---VEEAVQKACEVR-FI-HSKG-------GFEIR-NWV SNSA-DV-LQQL--GE-----SKSNQIIHINA-----------------------D-KST GN--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PF VRPFSYTGVDFFGPIN-------------------------------------------- ----------------------------VI--VG-R-----H-TE-----KR-WCA---L -FTCFG--TRAIHLEVVHSLSTPAC-----LMAIRRF-ICRR-GIPMEFFSDNGTNFVGA SKEI-----------AKK-IEI-D----------------------CS---EALTCSRTR ----WNFNPPSAPHFGGVWERLVRSVKKAMEV-LD--D---G-RKL----TDEVL----- --LTT-----LAEAEDLVNSRP--------LTY------------V----PQEPGNCGSL T---------------------PN-------------SF--------------------- ----------- >596/1-544 ---PTKRQVLQVVMSLYDPLGMISTFLIHGKIFIQS-LWRA-G----------I------ -DWDE-C-IPE--SLLEEWNKWIGLIAGLQ---E-IMIP--RCY--F------------- -TGYSPE-SLDTL-ELHV-FVDGSEN-AYC-CVAYFR--IID--RG------QPRC-A-- LVAS---------------------------KTKV-APL--K-F---------------- --------------------------------LSIPRMELQAAL-IGV-RLAKSIEEN-- -H------T-LRV---TRR---YF---------WT------------------------- -------------------------------------WFLPLGVV-------LNPK-K-P GKM-RLIWDAAAE-V-KG---VSFNSVLLKGPDLL--TSLPAVLCRFR---QRQI--AVT GDIKEMFHQIQIRRA--DRSAQL-----F------LFRGT-----GE---------H-IG VYMMDVATFGSTCSPCAAQYV-KNLN------------A----KEF-EKEF--P-EAAAA I-IEN--HYVDDY-LDSRD-T---EDEAAKIALDVK-KI-HAKA-------GFEIR-NWM SNSK-TV-LERV--GE-RSSE----DVKSFXM-----------------------D-KSG IA--E-----------------RV--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------PY VRPFTYTGVDYCGPFL-------------------------------------------- ----------------------------VK--VG-R-----S-LV-----KR-WIA---L -FTCMT--VRAIHLEIAYSLSADSF-----KMVIRRF-IARR-GAPLEIFSDNGTNFRGA SNELK-E-E------IKM-INQ-S----------------------LA---ATFTNTTTK ----WRFNPPLAPHMGGCWERLVRSVKTALAG-LE--M---V-RNP----DDETL----- --WTL-----MVEAEAMVNSRP--------LTY------------V-------------- ----------------------PL-------------DT--------------------- ----------- >597/1-532 ----TRRGVLSVVSSIYDPLGFLAPFVLTAKHLLQI-MSRR-R----------V------ -GWDD-P-LPQ--DIVQEWKKWLDGLHQLQ---S-FEVT--RCL--K------------- -PPNFDN--TMSA-QLHH-FSDASEE-GFG-TVTYLL--QHDC-KG------QVHC-A-- FIMG---------------------------KARV-APL--K-P---------------- --------------------------------ITVPRMELTAAV-VAS-RMDKLWRNE-- -L------R-MEL---QES---VL---------WT------------------------- ---------------N---------------RGDGKVWYLPHHGV-------YHPQ-K-- KKI-RVVFDCGAM-F-RG---VSLNAQLLQGPNLT--NSLVGVITRFR---KEPV--VLM ADIEAMFHQVRVPHS--DSDLLR-----F------LWWTN---GDHT---------LELV EYRMVVHLFGATSSPNCSSFA-LRKC------------T----EDN-QHLF--TSNVTNT V-LHN--FYVDDC-LVSVS-C---EEEAVMLYHGLR-AL-CKKG-------GFQLL-KWI SNCR-NV-INAI-------PQHERSKEVKNID-----------------------LN--- ------------------------------------------------------------ -------R---------------------------------------------------- ----------------------------------------------------------PD EPPFTRVGVDCFGPFE-------------------------------------------- ----------------------------VK--RG-R-----S-MV-----KR-YGV---I -FTCLA--IRAVHLEVLSSLETDSF-----INGFRRF-NARR-GQVLELHSDNGTNFVGA ERELK-E-------GVRRWNHS-Q----------------------IS---HTLLQKGIK ----WIFNPPTGSHHGGVWERLIKSVRKVMNSVLK--T---Q--SL----DEEGL----- --HTF-----LWK----------------------------------------------- ----------------------------------------------PKPLXX-------- ----------- >598/1-517 ---PTKRELLSLVMSIFDPLGLVANFVVHGKILVQE-VWRS-G----------I------ -GWDD-R-IPE--ELSASWHRWVLALHSLA---Q-VQID--RCY--F------------- -PGYDAE-TLNSL-ELHV-FVDASLN-AYA-AAAYFR--VVQ--RE------TVRC-S-- XVSS---------------------------KTKV-APL--K-Q---------------- --------------------------------LSVPRLELQAAV-LGT-RLMKTVVSS-- -H------T-LPI---GRK---FL---------WS------------------------- -------------------------------------WYLPLGVV-------TNPK-K-P EKV-RVVWDAAAT-V-KG---VSLNSVLLKGPDLL--QSLPMVLCRFR---QREV--AIN ADIKEMFHQVLIRPE--DRQAQR-----F------LWRNN---P-SL---------P-VE VFVMDVAIFGSTCSPSSAQFA-KNRN------------A----QEF-AREF--P-KASTA V-LEN--HYVDDY-LDSVD-T---VDEAVDLATEVK-SL-HERA-------GFELR-HWL SNKT-DV-LEQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY IRAFTFTGLDYFGPVN-------------------------------------------- ----------------------------VR--IG-R-----K-NV-----KR-WAA---L -FTCLT--TRAVHLEVAFTLSTESC-----KLAVRRF-IARR-GAPLEIYSDQGLNFQGA RKELQ-E-A------VRK-MNQ-E----------------------LA---STFTNAATE ----WKLNPPYAPHMGGIWERLVRSVKNALAA-ME--T---Y-RNP----DEETF----- --LTA-----LAEAESIVNTRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >60/1-534 -----KRQVLSDVSRIFDPLGLLAPVIVQFKILFQE-LWLL-N----------L------ -DWDS-P-LPT--KLADRWRKYREDINNIR---Q-LKIR--RHI--G------------- --YVGK-----RI-ELHA-FSDASIK-AYA-AVVYSR--IVNQ-DG------SIEV-S-- LIAA---------------------------KTRV-APL-------K------------- ---Q----------------------------QSLPRLELCGAL-LLS-RLIASIKLA-- -W-K----D-L-E---STV---YA---------WC------------------------- -------------------------------------------PV-------I------G TKL-RIVFDGSYKDK-SG---RSLNDELLVGPSIQ--RNLMDVCLRFR---LYKF--VFC ADIIKMFRQIWISEN--HRNYQR-----I------VWREN---P-TE---------EL-Q HYQLCTVTYGTACAPFLAVRV-LEQL------------A----IDL-KHKY--P-TAAKI L-LED--FYVDDV-LTGAN-T---EDQLIRNKDELI-QL-LGRA-------QLELG-KWV SNTH-GI-GPLEEAAA------TSVTGDA------------------------------- --SSV-----------------KV--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------RQ AFPFENTGCDYAGPIM-------------------------------------------- ----------------------------MKTH--KGRT---ARKE-----KG-YIC---L -FVCMA--TSALHLELATDLSTDTF-----LAALRRF-ISRR-GKCVTMFSDNGRNFVGA KRSLN-E-------MEQLVQSQ-LH------------------NNKIA---EALSIEGIN ----WKFIPPHAPHWGGKWESAVRSVKLHLHRVIG--H-----AVL----TFEQM----- --HTL-----LTQVEAVINSRP--------LCA------------T-------------- ----------------------SD--------TD-----------V-------------- ----------- >600/1-548 ---PTKREVLAYIMSIYDPMGLISNLSIHGKILMQE-LHKA-T----------L------ -NWDD-E-IPN--HLHDHWNTWVTTIKEAE---N-LEIP--RCL--T------------- -NGT--V---DEV-ELHT-FVDASDK-AFA-AAVYCK--STNS-NG-------TYI-T-- LVAG---------------------------KARV-API--K-G---------------- --------------------------------LSIPRLELQAAI-LGT-RLTNQIRKD-- -L------R-LKV---SKI---TY---------WS------------------------- -----------------------------------RTYYLPHFVV-------VNKN-K-- AKP-RLVFDAAAK-I-AD---KSFNSELLSGPDIN--EPIHGVALRFR---ENRI--AVS GDIQEMFHQTRITAA--DQDSQR-----I------LWRDC---N-TD---------KPAE VYVLQVMSFGATCSPFCAQYV-KNKN------------A----ENF-AEMY--P-EAAVA V-KKQ--HFVDDY-LDSFS-N---LEDAKKITNQVI-EI-HQHA-------GYYIR-NFL SNDK-EL-MKAI--------PQDRRHKLFT-K-----------------------PMEDK DSHAE-----------------KV--LG-------------------------------- -----IYW---------------------------------------------------- ----------------------------------------------------------PY VHPFTHCGVDYFGPFE-------------------------------------------- ----------------------------VV--VK-R-----S-TE-----KR-WGV---I -FTCMS--SRAVHIEMAEKLDTDSF-----IVCLRTF-QNRR-GKITHIYSDNGTNFVGA NNIMA-Q-------LVSDINTR-M----------------------GR---SEAAKMEIK ----WTFNPPAAPHFGGVWERLIRIIKSALQVLLK--SWG-E-RTP----RCETL----- --RAA-----FVQAEFFLNARP--------LTH------------I-------------- ----------------------PV-------------DN--------------------- ----------- >601/1-551 ---WTRRKVYSIIAQLWDPSGITAPVISWAKIRMQL-LWIA-V----------Q------ -GWDD-P-LSQ--DLSSRWTEFYQQLPALS---Q-IKVE--RYA--F------------- --IN-H-PM--LI-QFHV-FSDASEA-AYG-ACIYAR--SIDQ-LG------QIKV-E-- LLAA---------------------------KSRP-ASL-------K------------- ---K----------------------------TTLARLELCGAH-VAA-KLHRVTVKA-- -L-K----M-E-G---TET---WF---------WS------------------------- ---------------------------------------LPHHPV-------IKES-SST TKI-RPVFDGSAKTT-SN---YSLNDALMTGPVLQ--DPLFDLVLRFR---KHSV--ALV ADIEKMYLQVKVHPD--DTPLQR-----I------LWRFS---P-DE---------PI-A TYEMNRVTFGLAPSSFLATRC-LQQL------------A----EDE-GDRH--P-RAKAA L-IND--FYVDDY-VGGAD-S---ESEAILLRQDLE-QL-MPKG-------GFRLR-KWM SNAK-GA-LEGLPADELGTGS--T-L-NF----------------------------D-- -QEQV-----------------KT--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------TP ARAFTVTGVDYCGPVY-------------------------------------------- ----------------------------LKPV--HRRA---AAQ------KA-YIA---V -FVCFG--TKAVHLELVGDLTTSAF-----LGALRRF-VSRR-GLPSEIHSDNGLNFKGA SNHLR-E-------LYDLLHDP-AV------------------NSQIV---NETSQRGIV ----WKFIPPRAPNFGGLWEAAVKSAKTSLIRVLG--Q-----RRL----SFEDM----- --TTI-----LIQIEATMNSRP--------LTP------------L-------------- ----------------------SE--------DPD--E-------L-------------- ----------- >604/1-523 ----TRRTVLSVLAGIFDPLGLIGPCTLEAKKFFQK-LWD-ES----------H------ -GWDT-E-LSI--GESEHWKRICADWNG-----S-IIRQ--ERF--V------------- ----L-GKNND-I-QIHV-FTDASET-SYA-AAVYLR------SE--------SKT-R-- LVFS---------------------------KVRL-KPR--K----ARET---------- --------------------------------MTIPRMELMGVL-LGV-RATAFVSAQ-- -I------H-RPIT---AT---HL---------WC------------------------- ---------------------------------------LPHHAV-------ITP--K-- -KL-RVVYDASAHPK-GQ---ACLNDCLYRGPVLL--PDLAGVLLRFR---NCAI--PVL ADVEKAFLMIELEPE--DREVCK-----F------LWAKD---P-MQ----PPTGENL-A VYRFCRVAFGVVSSPFMLAAV-IRAH------------L------AKFGP---E-QD-AV L-FRN--VYVDNL-LIECE-S---EEEARTKAIAAK-EV-FKQA-------KMNLR-EYI SSST-DV-MSALPEEDR--L---------------------------------------- EQKQA-----------------KV--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------QR RRPFESVGLDYLGPT--------------------------------------------- ----------------------------LARQ-AGVVV------------KV-WIV---I -ITCLS--VRAVYLEPTYDLSAPSF-----INVLRRF-ISRR-GKPRRILSDNAPTFVQT GKALK-T--------------L--A---MS-------------D-DPA---EFSARSGIX ----WHFIPQLSPWAGGIYERLVALVKHSIQRTLG--R-----RIL----PCDDL----- --SAF-----LTEAEASINSRP--------LTI------------V-------------- ----------------------S-----------------------------DA------ ----------- >606/1-533 -----RRAVLSSLAGIYDPLGLLSPSILPAKLFFQK-LWD-EG----------R------ -DWDS-P-LSE--EESSVWEQFLKGWRD-S---N-ISLP--RRA--L------------- ----S-TSTDK-I-ELHT-FVDASSC-AYA-AAIYLR--GVNKNT--------VTT-S-- LIFS---------------------------KNRL-KPK--K----GGKT---------- --------------------------------LTIPRMELIAIL-IGV-RATAYIEKE-- -I------G-VPLA---EI---HL---------WS------------------------- ---------------------------------------LAHHAV-------IT---H-- -KI-RPVFDASAHPR-GQ---PSLNDCLLRGPVLL--PELVGLLIRFR---LPKF--VAI SDIESAFLMVGLHPS--DREFAK-----F------LWVKD---I-SR----QPEGENI-Q YYRFARVAFGVICSPYLLAGV-IRHH------------L------GKYGK---G-VA-AE L-ANS--LYVDNL-HLGAE-T---WPELLDKCQRAK-EI-FSEA-------RMNLR-EFS SNSS-EL-MRAIPENDR--L---------------------------------------- DSKEP-----------------KV--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------QQ RRPFQSIGIDYAGPT--------------------------------------------- ----------------------------LTKF-NGVQI------------KC-WLV---L -ITCLT--TRAVYLEPSLDLTALSF-----INVFRRF-ISRR-GRPEKVLSDNGRNFVLA EKAIS-S--------------A--L---PP----------------------LLAENKIE ----WKFIPALSPWAGGVYERLIGLAKSCFKRTLG--K-----QIL----PYDQL----- --STF-----IAEVEAALNSRP--------LTH------------V-------------- ----------------------SD--------GEG--A-------PLPLRPIDF------ ----------- >607/1-557 ----TKRSILSTIAQVYDPLGIVSPALVPAKHLLQK-VFE-AN----------Y------ -KWDT-E-VSD--DIKKQWQKIMSSWKDXS---E-VEFN--RIV--S------------- ------TSS-DQL-EYHC-FTDASGH-GFG-AAVYAR--E---SNM------QPKV-A-- LIFA---------------------------KSLV-RPA--S---LPINA---------- --------------------------------STIPKLELQAMT-LGA-KIFRFLNQE-- -L------K-VATD---NL---TI---------WS------------------------- -----------------QLAHGVIELVPNPGESTGPVHYLPHRAV-------LKM-DKAY TKV-RIVMDASARPP-SQPSAPSLNNCLHTGPLLL--KQLIGILLRFR---FMKR--VIL ADIEKAFLQLGVRES--DRDATR-----F------LWVKN---P-KEIELDQFQYAPC-I VYRFCRVSFGLTVSPFLLNAT-IREH------------L-------SLYES--K-VA-RS I-EEN--LYVDNI-MMCLN-P---SENATSACLEAI-EI-FKAG-------GMKLR-EFF GLKK-SE--RQIPSEDL--AP--------------------------------------- NQEET-----------------KI--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------SS SRPFTTTGIDYFGPMK-------------------------------------------- ----------------------------IKGHSKNTLE------------KX-YGA---L -FTCMS--VRAIHLELAEDLSAEAF-----LRAYRRF-TARR-GIPSLIISDNATNFTLG SKIVR-E--------------L-NS---EM------------------------KFKGTE ----WKFITPRNPREGGAWERMVGITKMSIRRCIG--R-----NLL----QKHDL----- --QTL-----LCEVEAIVNSRP--------LTF------------M-------------- ----------------------SE--------K--------------------------- ----------- >608/1-560 ---NTXRQLLSDSSRLFDPYGWLSPVIVKIKILFQQ-LWLS-E----------V------ -SWDD-P-LPA--TVEVPWKDIKESLRFLE---Q-IRIP--R-Y--I------------- -VNFNGK--V----QLHG-FSDASEM-AYG-AVVYSR--AMDD-AG------NIFV-N-- LVAA---------------------------KTRV-API--K-Q---------------- --------------------------------VSLPRLELNAAV-LLA-ELMQRVTQA-- -L------S-HIT---VEH---WA---------WT------------------------- -------------------------------------FYLPHHAV-------IKAD-SST TKL-RVVFDASSASG-SG---VSLNDRLLSGPNVN--QDLFDVHLRFR---SNDV--AFA ADAEKMFRQVLVHPL--DRDYQR-----I------VWRND---P-SK---------PI-K HFRLCTVTYGTKPAPFLAIEA-MREA------------A----RSY-ETVY--P-VAAER I-VLD--MYVDDF-MSGAK-N---IDEARKLKDXVC-EI-LKSA-------GFNLR-KWT TNRP-EL-LGDSEYSEQIPMEMKL-AEQPD------------------------------ ---VV-----------------KA--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------MA TRAFTHVGVDYAGPFK-------------------------------------------- ----------------------------IHAM--CVRG---IKAT-----KG-YLA---V -FVCMA--TKAVHLEAASDLSSNVF-----IAALKRF-IGRR-GYPNEIWSDNGTNFVGT DRWLQ-E-------IQQSLKNN-SK--------------------AVD---HFLTNQGIK ----WVFNPPSAPHRGGIWEAAVKSAKKHIIAVLG--S-----EPL----TFEEF----- --STI-----LSQVEACMNSRP--------LCA------------L-------------- ----------------------SS--------NPD--S-------YEALTPGHF------ ----------- >609/1-561 ---WTKRKVFSAIAKLYDPLGLVSPVVAWAKIRMQH-LWLA-A----------V------ -DWDD-P-IPE--DIVDKWEDFAAQLPLLE---G-YKVS--RFI--F------------- --AS-D-SS--SV-QFHV-FSDASEV-GYG-ACVYAR--STDK-EG------KINI-E-- LIAA---------------------------KSRV-APL-------K------------- ---R----------------------------LSLPRLELCAAL-LGA-KLYAKISAA-- -L-R----M-E-G---IPC---RF---------WS------------------------- ------------------------------LDQGKTVCYLPHHPV-------FKEA-SST TKV-RVVFDGSAKTS-TN---HSLNEALLTGPTIQ--DELLDLMLRFR---KHAV--ALV ADVAKMYRQILVHDD--DKPLQR-----I------LWRFN---P-SE---------PI-R VYELQTVTYGLSPSSFLATRV-LKQV------------A----LDS-GSKY--K-LAANA V-LED--FYMDDF-LSGAD-T---LEDATLLQKEVQ-AL-LAEG-------GLELR-KWS SNKP-QV-LQNLPIESLGGEK--T-L-HFE---------------------------S-- -EHKI-----------------KT--LG-------------------------------- -----VGW---------------------------------------------------- ----------------------------------------------------------XP SRAFTVVGVDYCGPVY-------------------------------------------- ----------------------------IKPV--HRRA---ASR------KA-FIA---V -FVCFA--TKAVHLELVCDLSTDAF-----IAALRRF-IAHH-GMPAEIHSDNGTNFQGA NNTLA-E-------LYRLFEAK-RT------------------REAIR---KECTMHKIQ ----WHFIPPRAPSFGGLWEAAVKTAKTSLAKTLG--S-----TQL----SFEDY----- --ATV-----LAQIEANMNSRP--------LTT------------L-------------- ----------------------SS--------DPT--E-------V-------------- ----------- >610/1-556 ----TRRKLLSQLAKIFDPLGFFGPVITTAKLILRE-VGEL-Q----------I------ -XWDD-P-VPX--DVGSKWRNFRXEMTXLX---E-VRLP--RWI--S------------- --WKGXLKL-----ELHG-FADASDL-AYG-ACLYVR--AXFP-DG------SXXM-R-- LIXS---------------------------KSRI-LPK--K--KAK------------- ---EKA--------------------------ITTPRAELLAAL-LLA-RLVVKFLDA-- -TE-------LK------------------------------------------------ ------------------------------SEKHNSVFYLPHHCV-------LRPT-STT TKL-RVVFDGSAKSS-SG---VSINDVLMTGPTIQ--NDLIAILLRFR---GFQY--VFT LDIPKMFRQVDVRAE--DTKYQR-----I------FWRYN---R-EE---------PL-T IRELTTVTYGLAPSPFQATMA-LKQT------------A----EDH-EDEF--P-EAAKV V-EKG--TYMDDI-LSGAD-T---IDAACQLQREVT-GL-LAKG-------CFDAH-KWC ANHP-DI-LEDVPDALRGNSF------EVT---------------------------DDN SKLIV-----------------KT--LG-------------------------------- -----VTW---------------------------------------------------- ------------------------------------------------------------ --VFTNTGVDYAGPFW-------------------------------------------- ----------------------------VKSSSAARKP---LIT------KA-YVC---L -FVCMQ--TRAIHLELVSDLTTDAF-----LAALRRF-TSRR-GYPKTMRSDNATNFVGA KTELH-E-------LWQLFQNQ-CS------------------TKKII---SFCTEKGME ----WSFIPPRSPHFGGIWEAGVKQVKHHLTRIVG--D-----RKL----TYEEL----- --YTT-----LTQIEAVLNSRP--------LAP------------C-------------- ----------------------SD--------DPS--D-------Y-------------- ----------- >612/1-542 ---PTKREVLRVLMSIFDPLGLIAHFLIYLKMLLQE-IWRS-G----------T------ -QWDE-E-ISD--TLFAKWQQWLRVLPEVE---G-VEIP--RCY--H------------- -IRKFTD-C-----ELHT-FVDASEN-GFA-AVSYMR--FSN--GK------EVEC-A-- LVTA---------------------------KTRV-APL--K-F---------------- --------------------------------QSIPRLELQAAV-LGA-RLARTVAEA-- -L------S-IKA---TRR---LF---------WT------------------------- -----------------------------------GFTCLPVFSV-------FNPN-K-P GKI-RIVWDAAAT-I-FG---VSLNSVLLKGPDQL--CSLFSILLQFR---EHPI--GLT GDIREMFHQIQIREQ--DRSCQR-----F------FWRDK---F-GK---------A--A VFEMDVMTFGACCSPSSAQFV-KNLN------------A----GRF-VGKY--P-QAVEA I-IKR--HYVDDM-LVSVK-T---EKEAVDLAHQVK-YI-HAQG-------GFEIR-NWI SNSQ-LV-LQSL--GE---DDVK---SKNLDL-----------------------SAE-V IA--E-----------------KV--LG-------------------------------- -----LWW---------------------------------------------------- ----------------------------------------------------------AY SRPFTHVGIDYFGPME-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -ATCMT--TRAVHIEIAHSLNTDSC-----IMAIRNM-IARR-GIPRYIYCDRGTNFVGT SRELS-R-------VEGELDLE-T----------------------MM---KEFTTSETA ----WCFNPPMSPHMGGCWERLIRSVKNSLKSLNL------P-RRP----SDEVL----- --RNA-----LTEIENVINSRP--------LTH------------V-------------- ----------------------PI-------------ED--------------------- ----------- >613/1-550 -----KRYILSEIAKSFDPLGLQAPVCVTAKLILRQ-LWRK-N----------V------ -SWDE-E-VSQ--DIAESWNKFRGGLQALM---N-LQIE--RRV--I------------- --APKRIAL-----ELHA-FSDASQD-AYG-TCVYVR--SILA-DN------TVEV-H-- LLIS---------------------------KSHL-APR--------------------- --------------------------------ATIPRLELCGFR-LMS-RLVVKVVSA-- -L-K----V-K-F---NRM---VL---------YS------------------------- ---------------------------------------LPHHAI-------LKPS-SST TKL-RTVFDASAQTS-SG---LSLNDTLMVGPTIQ--DPLFDIALRFR---TYPY--VFT ADISKMYRMVRVHPD--HTKFQR-----V------FWRTD---P-SE---------SL-K TLELLTVTYGTASAPYLATRT-LKQL------------A----QDE-GQAY--P-RAAKI L-END--FYIDDA-LAGAD-T---LKELLLARDELE-EL-LEKK-------GFELH-KWC SNSA-EF-LDTIPDERREKQV------SFE---------------------------LSG VNEMI-----------------KT--LG-------------------------------- -----ILW---------------------------------------------------- ----------------------------------------------------------TQ AYPFERVGVDFAGPIY-------------------------------------------- ----------------------------VRK-GHPRKP---VYC------KA-YVA---L -FVCMV--TKCIHIELVSNLTTDAF-----IAALHRF-VARR-GLPSDVYSDNATNFAGA SSELH-E-------LYALLTQQ-LT------------------KDALQ---EFCLPKEIR ----WHFIPPRSPHXGGLWEAGVKSAKHLIKRNAG--E-----TKL----TEEEW----- --STL-----LTQIEGIXNSRP--------LVP------------X-------------- ----------------------TA--------DPG--D-------L-------------- ----------- >615/1-532 ----TKRIVLSQMSSLFDPLGLLGPTVVRAKIIVQA-LWKC-Q----------L------ -QWXT-P-LPE--QFEKEWISYQQDIHHLG---G-LKIP--RLV--M------------- --TVPY-QR--L--EIHG-FSDASLQ-AYG-ACIYVR--TIDA-EG------RCNV-Q-- LLTA---------------------------KSRV-APL--S-S---------------- --------------------------------KSIPRLELSAAL-LLA-HLLAHVLKT-- -T-S----L---D---APV---YL---------WT------------------------- ------------------------------EVNIRPQFVLPHHGV-------LKLE-SAT TKL-RTVFDASCKSX-SG---LALNDVLIPGPAIQ--DMLVEIVLRFR---LHRF--VVS ADIEKMFRQVLVHPT--DQPLQR-----I------LWRDN---P-EL---------PI-K VYQLITVTYGLNNSPYLATRV-LQQL------------A----TDE-EHRF--P-YAASV A-RRD--FYVDNL-LTGSN-N---VEELKVIVQQMI-DL-LAAG-------GFPLR-QWS SNSE-EV-LNV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TK AFPFENVGVDFAGPVF-------------------------------------------- ----------------------------LRAP--SKRA---SPI------KA-YVA---V -YVCLA--VKAVHLDLVPDLSSEAF-----IASLHRF-TGRR-GKPSNIYCDNGRNFVGA QRELK-E-------LRQLFVSQ-QH------------------QDAVI---HDCSTNNIE ----FHFIPPRSPTLGGIWEAAVKSMKLHLRRILG--N-----SLL----PETEF----- --RTA-----LIQVEATLNSRP--------ITA------------M-------------- ----------------------SE--------DPQ--D-------L-------------- ----------- >616/1-560 ---PTKREVLRVLMSIFDPLGIIAHFLMYLKVLLQQ-IWRS-G----------V------ -QWDQ-E-ITN--DSFTKWQHWLKLLPQVE---Q-VEVP--RCY--R------------- -S-SIQK-PE-EA-ELHI-FADASET-GMS-AVAFLR--FVT--QE------TVEC-R-- IVAA---------------------------KTRV-APL--K-F---------------- --------------------------------VSIPRLELQAAV-IGT-RLAHTIIDS-- -L------S-IKI---TKK---YY---------WT------------------------- ---------------S---------------QQSSRVWYLPVFPV-------VNPN-K-P GKV-RLVWDCAAC-S-FG---VSLNSALLKGPDQL--CSLLAILMQFR---ENRV--GLT GDIKEMFHQVRIQKE--DQQCQR-----F------LWQNE---H-GD---------V--V TYVMQVMTFGACCSPSCAQYV-KNLN------------A----ERQ-SGEF--P-KAAEV I-QKK--HYVDDM-LVSLE-T---DEEAVKVAKDVK-HV-HQQG-------GFEIR-NWV SNSP-KV-LQAL--NE---SGIN---EKDLDL-----------------------SAE-I ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY SPPFTHTGLDFFGPYE-------------------------------------------- ----------------------------VA--VG-R-----R-IE-----KR-WGM---L -ATCLT--VRAIHIEVVHSLTTDSC-----IIAIRNF-IARR-GTPSVFYSDRGTNFVGA ARQLK-E-------AAAAVNVD-E----------------------VM---REFVTVDTT ----WSFNPPLAPHMGGSWERLIGSVKRNLQSINP------P-RNP----TDEVL----- --RNL-----LIEVENIINSRP--------LTH------------V-------------- ----------------------PI-------------NDDCAPALTPNHF---------- ----------- >618/1-540 ---CTKRQVLSDVAHIFDPLGILAPVVVQFKILLQE-LWLL-D----------L------ -DWDS-E-LPM--KQAHSWQMHRKDISSLQ---Q-LKIP--RFI--D------------- --SHMD-----HI-ELHA-FSDASLK-AYS-AVVYSR--VEYS-DG------SIGV-Y-- LVAA---------------------------KTRV-APL-------K------------- ---L----------------------------ATRPRLELCGAL-LLT-RLVKAIQAS-- -L-G----K-K-E---VKH---CSNDPNGLPKCLT------------------------- ---------------------------------------MPHHPV-------L------G AKL-RVVFDGSFQDQ-DG---RSLNDALHIGPCIQ--RNLFNVCMRFR---MHKF--VFS ADIVKMFRQILVAPK--HQDFQR-----I------LWREH---P-SA---------PL-K HFKLCTVTYGTASAPFLAVRV-LEQL------------A----KDH-EHEF--P-RAAKI L-LED--FYVDDV-LTGAM-T---EEELIDIQTELV-AL-MSRA-------QLELG-KWI SNST-RL-CTAQGDRG------NMST---------------------------------- --ATS-----------------KV--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TM SYPFLNTGINYAGPYY-------------------------------------------- ----------------------------MKCS--KYRG---QNMY-----KG-YIA---L -FVCMA--TKAIHLEAVIDXKSDAF-----LAAMRRF-IARR-GKYLNIYSDNGTNFVGA AKKLE-K-------EFKKTIQE-NT--------------------KIS---SMLEKEQIK ----XHFIRAASPHFGGIWEAGVKSVKYHLT------------SKK----TLVES----- --SRL-----DTTLNPTNKNAH--------LVW------------L-------------- ----------------------KF--------QF------------------RC------ ----------- >619/1-556 ---PTKRSVYSDIAKLYDPLGLLGPLIFAAKVKLQK-LWHL-E----------L------ -DWDE-T-LST--DEAESWECFRNQIIQMG---E-ISIP--RCV--L------------- -PYK-S-PT--QI-ELHG-FCDASDL-GYG-ACAYIR--SVDW-TE------DCSI-L-- LLTS---------------------------KSRI-APL-------K------------- ---NAK--------------------------LTTARLELCGAL-VLA-RLISNITQN-- -L-S----L-T-F---SRI---TL---------WS------------------------- -------------------------------------YFMPHHAV-------FNPA-STT TKT-RVVFDASATTT-TG---TSLNDHLFVGPVVQ--RKLADTVLRFR---IPKI--AFT ADITQMFRQIVVRPQ--DRKWQQ-----I------FWRSH---P-DD---------FL-E VYQLATVTYGTACAPFLATRV-LKQL------------C----EDE-IKRF--P-LASKA G-TED--YYMDDL-LSGAD-T---IEEAVAMQAEFV-EM-MASG-------GFVLH-KWA SNHP-AL-LQSVPNSDNEQIA------------------------------------FFE DEKTT-----------------RA--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------EG VYPFLYTGVDFCGPIY-------------------------------------------- ----------------------------IRQH--NKRS--TVTY------KA-YVA---V -FVCFA--TRAIHLELVGDLTADAF-----ISALHRF-VSRR-GKCAKMFSDNGLNFVGS KNKLK-E-------MYDMFRSQ-QL------------------KGKLD---DFCTKSAIE ----WHLIPPSAPHFGGLWEAGVRSAKYHLKRITG--T-----ANM----NFEEY----- --TTV-----LTRIEALLNSRP--------ITA------------L-------------- ----------------------AE--------DPS--D-------I-------------- ----------- >62/1-539 ---FTRRGVLSVVNSLYDPLGFVAPITIQGKSLLRQ-LSET-V----------K------ -DWDT-P-LPT--DKQSKWESWKQSLKDLE---E-LHIP--RCY--T------------- -STSLAE--SQRR-EIHI-FSDASTE-AIA-VVAYLK--VRDT-CG------QPHI-G-- FLFG---------------------------KAKL-APK--P-E---------------- --------------------------------HTIPRLELCGAV-LAV-EIADFILCE-- -L------D-IHI---DAV---KF---------YT------------------------- -------------------------------------WYLPSFGV-------YHPR-K-P KQI-RVVFDSSAK-Y-QG---MSLNDVLLTGPNLT--NNLVGVLMRFR---REPV--AIT ADIQQMFHCFIVRED--HRNFLR-----F------LWHHD---NNIN---------SEVI EYRMKVHVFGNSPSPAVATYG-LRRT------------A----CEG-ENEY--GADAQHF V-ERD--FYVDDG-LKSLP-T---DEEAIDLLKRTQ-SM-LSEA-------NLRLH-KIA SNST-AV-MKAF-------QTDDHATEFKDLN-----------------------LGV-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ST DPPFTHVGLDVFGPWT-------------------------------------------- ----------------------------VM--AR-RTRGGEA-CN-----KR-WAV---L -FTCMS--VRAVHIEVIESMDTSSF-----INALRRF-LAIR-GPVRLLRSDCGTNFTGA CRELQ-F------------DTQ-P----------------------VK---DYLASNGCT ----WIFNPPHSSHMGGSWERMIGITRRILDSMLM--DL--NSTRL----THEIL----- --TTF-----LAEVSAIINSRP--------L--------------V-------------- ----------------------PV-------------ST--------------------- ----------- >620/1-548 ---PTKRDVASKMAETFDPLGLVSPILVPFKRLMQR-IW-NXD----------T------ -NWKD-P-IPK--ELLHEWRALCNNYIDRA-----ISLP--RQL---------------- ---T-XESGHSEI-HLLM-FSDASHD-IYA-SVCYAY--YIV-DGR------PPVV-S-- LLAS---------------------------KNKI-RPSKNE-N---------------- --------------------------------WTIPKLELLGIQ-CAS-NLACAIIAE-- -L------R---VNI-ASI---KL---------FT------------------------- -----------------------------------PKYNIPHRCV-------XKE-DSMT TKL-RIVLDASSHAA-GE---LSLNECLYAGTNMI--TPIFGILVRVR---FPPI--IVV ADIEKAFHQVRLQPE--FRNVTM-----F------LWLKD---V-TA----PATADNI-Q VYRFTRIPFGVASSPFQLAAY-ITYN------------L-------DNNPH--D-LN-KE I-KDN--IYVDNC-LFCVN-D---ASEISAIIKDSK-EI-FQKM-------GMNLR-EYI VNHP-ET-MQSLSPADR--A---------------------------------------- QQSTI-----------------KL--LG-------------------------------- -----YTW---------------------------------------------------- ----------------------------------------------------------TP SKPFSNVALDYLGPIM-------------------------------------------- ----------------------------YRXDDGRSAK------------KA-YVL---I -YTCLN--TRGAVLKVVPDGTAFRY-----IQTLKMI-FGEV-GVPKSIYSDNASTFKLS GEIIN-K-------DIKN----------AD-Y-----------SQSLV---EYLARELIN ----FKFITPLAPWQGGIYERVVKLVKTQITKECG--A-----RMY----DYYSL----- --QYV-----VSRAQSMVNNRP--------LIP------------H-------------- ----------------------AR--------SPG--D-------M-------------- ----------- >621/1-563 ---WTRRTILSSIAKLFDPLGLISPVVIVAKMLMQE-LASR-K----------I------ -AWDT-P-VPD--DIRKKWTTFYSELDKIA---E-LRIS--RFA--F------------- --AS-N-WV--DI-QFHC-FADASTV-AYG-ACLYVR--TTDQ-AG------NVRI-E-- LLAS---------------------------KSRV-APL-------Q------------- ---R----------------------------LPIPRLELCAAK-EAA-LLHSKVTKA-- -L-S----L-G-E---VRS---TF---------WS------------------------- ------------------------------SDNSKKVCYLPHHAV-------LKET-STT TKV-RVVFDGSASTD-SG---YSLNDALLKGPVIQ--DELLSLLIRFR---KHEV--ALV GDVEKMYRQVKVHPE--DAGLQR-----I------LFRFS---P-EE---------PI-R VFELSTVTYGLTPSSFLAIRA-LHQL------------A----ADE-GVAY--P-EAAKA I-VHD--FYVDDY-IGGAS-S---VDEAIQLQGDLD-TL-MKKG-------GFALR-KWC SNRP-EV-LTGIPADQLGTNL--S-I-SFD-------------------------ISP-- -EEKV-----------------KT--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------RP GRPFLITGVDYCGPFY-------------------------------------------- ----------------------------LKPP--RRNA---APP------KV-YIA---V -FVCFS--TKSMHLEMASDLSTASF-----LSVLRRF-IGYR-GVPAEIHSDNATNFSGA RNELK-A-------LYDLLNNS-IS------------------RTTIS---NELSQQGIQ ----WKFIPPRAPNFGGLWEAAVRSVKTALKKEIG--L-----QQL----TYDNF----- --LTL-----IVQITATLNSRP--------LSP------------L-------------- ----------------------SD--------DPT--E-------F-------------- ----------- >622/1-543 ---PTKRQLASFIASTYDPQGLLSPMGVSHKSLMAK-VW-KEK----------L------ -RWKD-P-LPT--NLLPEWEKIKASITDSS-----YTIP--RRV---------------- ---T-PIQGFSQA-SLIM-FSDASRD-HYA-TCAYLR--FEC-PDN------ITRV-Q-- LIFS---------------------------KTRI-RPINNE-H---------------- --------------------------------LTIPRMELLGVL-TAA-HAASTIHTE-- -M------N---IAL-SSL---TF---------FC------------------------- -------------------------------------YYIPHRVI-------IKP-DAQN TKL-RIVLDASSHMK-NE---QSLNQCIHPGPSIL--KSILGILFRSR---TKPY--MMI ADLEKAFHQVRLQPQ--HRNCTK-----F------LWLKD---Y-TK----PATPDNL-V TYRFTRLPFGVSASPFLLAVT-VLRY------------M-------ELNPH--P-IH-DK I-TQN--LYVDNV-MFTPD-S---AEELLENYRDST-AT-FSSM-------HMRLR-DFL CNDK-TV-MNAIPEQDK--A---------------------------------------- KSTIC-----------------KL--LG-------------------------------- -----HYW---------------------------------------------------- ----------------------------------------------------------QS CRPFQHIGLDYFGPIG-------------------------------------------- ----------------------------YKTETG-QXG------------KL-WCM---L -TTCLV--TRAVHLEVVPDNTTASF-----LLAMRRF-VGRR-GSPXTIISDNAPAFTLG YTMIN-A-------DINT----------LINS-----------SQTLT---CFLASKAIE ----VKQITPFAPWQGGVYERIVAIVKNMFYKXIG--R-----LQL----SFLEV----- --ETL-----LIECEGIINSRP--------ITA------------N-------------- ----------------------PI--------SI-------------------------- ----------- >623/1-544 ---PTKRQVASRLAETFDPLGLVTPILVAFKRLMQN-CW-LDG----------V------ -KWNE-P-LPP--QLLSEWRKVQEQFKDEE-----IVVP--REL---------------- ---T-SAYNYSSV-RLMV-FSDASKD-MMA-ASVYAL--YTF-EDK------HPTV-S-- LICS---------------------------KNKI-RPSKNE-K---------------- --------------------------------WTIPKLELMAIE-IAT-NLAVATVNE-- -I------R---LPI-TEV---CF---------FT------------------------- --------------------------------------NIPHRGV-------VKL-SSMT TKL-RIVYDASSHKR-DQ---LSLNDCVFPGPSIL--QSIFGILIRAR---MYKY--LVI ADIEKAFHQVQMQPE--FRSLTR-----F------LWLKN---I-EH----PATPDNI-E TYHFNKIPFGLACSPFLLAAV-IHHF------------L-------NKNPN--K-LN-EM T-KEN--LYVDNC-LYYTN-D---KGEIPEIVKAAK-QI-FXDM-------DMNLR-EFI VNEA-XE-MMKIPEKDR--A---------------------------------------- ASLSV-----------------KV--LG-------------------------------- -----YLW---------------------------------------------------- ----------------------------------------------------------EP STPFEHSGIDYLGPVM-------------------------------------------- ----------------------------YTRDDG-SLS------------KA-FIL---I -YTCLV--TRGARLEIVPDGTVERY-----LEAMSIV-FSRS-GVPKTIYSDNAKTFQLG EKIIN-E-------DIAG----------DE-A-----------SESLT---SFLANQEID ----FNYITPLAPWQGGVYERIVKLVKHQLMKEIG--D-----LNL----DFQGL----- --RRV-----LAGVEAMINSRP--------LTP------------H-------------- ----------------------PK--------RPN--D-------M-------------- ----------- >624/1-549 ---PTKREVASKLAETFDPLGLVTPLMVPFKRLMQK-VWLKSD----------T------ -NWKD-K-IPK--ELLSDWRALCNIFIDRE-----IVVP--RQL---------------- ---T-THYENSEL-HLLL-FSDASQD-IYG-ACCYAY--FAV-DGK------PPTV-T-- LFTS---------------------------KNRI-RPSKNE-N---------------- --------------------------------WTIPKLELLGIQ-CAS-NLACAVVAE-- -L------K---VKV-TSI---KL---------FS------------------------- -----------------------------------PKYTIPHRGV-------VKE-DSLT TKL-RIVLDASSHAR-GE---LSLNDCLHAGTNMI--IPIYGILLRMR---CPRY--ILV GDIEKAFHQVPLQEE--FRNVTM-----F------IWLKD---P-SR----PADDDNI-Q LYRFKVIPFGVSSSPFLLTAY-IVFN------------L-------DNNPH--D-LN-NE I-KEN--LYVDNC-LFCTN-D---KSEIASKIKGTK-LI-FQKM-------GMNLR-EYI VNDP-DT-MQSLPPAER--A---------------------------------------- QSSVI-----------------KL--LG-------------------------------- -----YRW---------------------------------------------------- ----------------------------------------------------------TP SKPFSKVGLDYLGPIV-------------------------------------------- ----------------------------YKKDDNRKTG------------KA-YIL---V -YTCLT--TRGVVLRVVPDGTSQMY-----ILTLKMI-FHEY-GVPKTIFSDNASTFKLS GSMIN-R-------DIRE----------AT-Y-----------SHSLV---EFLAAEVID ----FKFITPLAPWQGGIYERVVKLVKIQLTKECG--T-----RTY----DYFSL----- --QYI-----VSSAQSMVNNRP--------LIP------------H-------------- ----------------------SR--------SPK--D-------M-------------- ----------- >626/1-560 -----KKKAVGEITMIFDPTQYFAPLYLQGKNILRQ-ISDH-T----------I------ -KWLD-Y-VSD--DIVEQIISYRQKIENST-----LKFR--RNI---------------- ----PNLNSRKPV-QLVV-FTDASEH-TYG-ACIYLKIEKPDL-KG------QFDI-H-- LLIA---------------------------KQRI-APKTKT------------------ --------------------------------LTIPRLELLGIL-IGV-RLLDYTIRE-- -M------N-LNI---EKI---EL---------FS------------------------- -------------------------------------YYIPYGLV-------FNKS-SNT TKV-RTVFDASSKKRGE----ISLNNALHQGPSLI--PDLQGILLRLR---QGKY--LLA GDIEKAFHAIEVNEK--DRDALR-----F------IRVKD---P-ER----PLHP-DNIR LMRFRNLPFGVNCSPFLLSMSILYAV------------R--------QANV--PENIIKA I-ESM--CYVDNV-FMLTD-D---FNELPKFYNLLK-EF-FGSI-------GMNIR-EFC VNHP-VN-F-------IKEEDKAQNL---ENI---------------------------- ----------------------KM--LG-------------------------------- -----YIY---------------------------------------------------- ----------------------------------------------------------TE SRPFQHIGVDFMGPFK-------------------------------------------- ----------------------------TYIRNSNDIE------------KC-HIA---L -FTCTT--TRLVHLERVPNLSTDEF-----LLALSRF-MSRR-GYPDSITSDNAATFKLT AEILD-R-------HSEREDNF-LAELAFEKI-------DQLKTNVLE---KEMTKKGIK ----WYFNTALAPWQGGFYERLVGVVKKALKHSLG--E-----SQH----RVKDL----- --ETI-----MAECESLVNRRP--------LTY------------I-------------- ----------------------DE--------DSE-----------------DC------ ----------- >627/1-557 ---PNKRQLLSVVMSLYDPLGLVSAFVIQGKILIQE-TWRE-N----------I------ -GWDD-K-ISS--KIFSRWKQWLTGLREMS---K-VKVS--RCY--F------------- -PGYDRD-SYNSL-QLHI-FVDASEE-SYA-AVAYFR--IKD--KG------EIRC-S-- LVAS---------------------------KTKV-APL--Q-S---------------- --------------------------------LSIPRLELMAAL-IGA-RLRKTIEDH-- -H------S-VRV---ART---FL---------WS------------------------- ---------------T---------------FDLRRIWYLPLGVV-------TNPN-K-P GKV-RLIWDAAAK-V-EG---VSLNDHLLKGPDLL--TPLLAVMFQFR---EREV--AIS ADIMEMFLQILIRPV--DRSVLL-----F------LWRDS---V-DQ---------P-IK VMVTNVASFGATCSPTQSQFV-KNLN------------A----LEY-EMDF--P-RASLA I-TKR--HYVDDY-LDSVD-T---TEEAITLAKDVT-MI-HGKA-------DFFIR-NWI SNKV-EV-LEQI--GE-----THPAAVKQFSA-----------------------S-KDC KF--E-----------------RL--LG-------------------------------- -----MIW---------------------------------------------------- ----------------------------------------------------------PY VRAFTFVGIDYFGPYM-------------------------------------------- ----------------------------VK--VG-R-----S-AV-----KR-WGV---V -FTCLT--IRAIHIEVARSLSADSC-----KKAIRRF-IARR-GAPQEIYSDNGTNFIGV SRELQ-S-E------IRA-IST-E----------------------LG---STFTDAYTQ ----WRFNPPSAPHMGGCWERMVKSIKLALGT-IP--V---D-DKL----DEKSL----- --ETL-----FAEAEMMINSRP--------LTF------------V-------------- ----------------------SL-------------QTTDEEA---------------- ----------- >63/1-521 ----TKRLLLSWIARIFDPLGFLAAFVVRGKMIMQS-IWIT-G----------A------ -DWDE-C-LPL--NIDQEARLWVNEAREIV---S-MRVP--RNL--L------------- -ESESDD--WT----IHV-FSDASEK-AYG-SVAYLR--R-QS-SG------EIQC-K-- FIAA---------------------------KSKV-APV--K-T---------------- --------------------------------VNIPRLELLGAC-LGL-KLAKKIVKP-- -I------G-CNI---NEV---CF---------WT------------------------- -----------------------------------EGWILPHFPV-------IKRD-RET TKI-RIVFDAAAK-V-EG---RCLNDNIETGPKLY--NDLFDVLIRFR---KNKV--AIV CDIAEMFLQIGIIKK--DRKYLR-----F------LW------K-KD---------NQLK FYEFNRLVFGLNAAPYLAQLV-AQEN------------A----RKF-KEKY--P-RAVET I-AES--TYMDDS-LDSVG-T---EKEASLLKAQLE-EI-WNKA-------GMRTQ-KWM SNST-KV-LE--------------------NV-----------------------PI--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP LQAFARIAVDFAGPFE-------------------------------------------- ----------------------------TIQGRG-K-----T-RQ-----KR-YMC---L -FTCLQ--TRAVHLEVAYALDTDAF-----IRAFIRF-MGRR-GKPLMILSDNGTNFVGA TNEVQ-E-------IKVD--SY-R----------------------FN---KFMSGNDIR ----WIFNPPLAPHFGGVFEALIKSAKKALQVIVG--S-----ADL----SDEEL----- --NSV-----FIKVESLLNARP--------LTT--------------------------- ----------------------QC--------SDSKEDL--------------------- ----------- >630/1-562 ----TKRLALSLIARLYDPLGLVGPVVTIAKVFMQS-LWTL-K----------D-DDDKP WGWDR-E-LPK--EYQTRWMKYQSLLPNLN---K-LRID--RCI--L------------- --LP-E-PE--II-QIHI-FSDASKL-AYG-ACAXVR--SITA-DG------LVKV-A-- LLSA---------------------------KSRV-APL-------Q------------- ---S----------------------------RSIPRLELCGAL-LAA-ELYKKVQSS-- -L-Q----L-D-----AES---FF---------WV------------------------- ------------------------------DDPTIKRFYLPHHAV-------LRED-SAT TKL-RVVFDASCKTP-AG---PSLNDALMVGPTVQ--EDIRSITMRSR---KHQV--MVV ADVKMMYRQVLVDPR--DTPVQL-----I------VWKPS---P-DQ---------PL-E TYELDTVTYGTASAPFLATRV-LIQL------------A----DDE-CSNF--P-LAAPV V-KKD--FYVDDL-FSGGK-H---AEEVIELRNQLE-AL-LAKG-------GFQLR-KWA SNNE-AV-LDGIPPENRALST--S-I-ELD---------------------------P-- -DQTI-----------------KT--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA SRAFSITGVDYWGPIL-------------------------------------------- ----------------------------LKPV--HRRA---APG------KA-YVA---V -FICFS--TKAVHLELVGDLSTAKF-----IQSLRRF-VSRR-GLCKHLYSDNGRNFVGA ANELK-R-------L---VNNK-DY------------------QNAVA---QECTAHQIR ----WHFNPPKASNFGGLWEAAIQSAQKHFVRVLG--K-----NTL----PYDDM----- --ETL-----LCQIESCLNSRP--------LTP------------L-------------- ----------------------SD--------DPS--D-------Y-------------- ----------- >631/1-547 ---PTKRDILSMLMSIYDPLGLIANFLMPLKLLLQE-IWRS-G----------V------ -SWDE-P-IEF--LHMQKWKSWLSYLPQAG---S-VRIP--RCY--N------------- -IRLSY--DQLNI-ELHT-FVDASEL-GYC-AVAYLR--FEK--AG------QVDC-V-- LVGA---------------------------KTRV-APL--K-F---------------- --------------------------------VSIPRLELQAAV-VGT-RLAKSIQEG-- -H------S-ISI---TQR---YF---------WT------------------------- -----------------------------------RIWYLPIFPV-------INHN-K-P GKV-RIVWDAAAA-I-GG---TSLNSVLLKGPDQL--EPLPFVLYKFR---ERRV--AIC GDIEEMFHQVRIDEV--DQQSQR-----F------LFQDK---P-DA---------PEPD EYVMNVMTFGATCSPSSAHFV-INEN------------A----ERF-AGQL--P-ATAGA I-RKC--HYVDDM-LASVD-T---EPEAIQLAKDVR-FI-HQQG-------GFKMR-GWI SNSS-TV-TEAL--NG---ENVS---DKNLDL-----------------------IKE-V AL--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF VRPFSYIGVDYFGPFH-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -VTCLT--VRAIHIEVAHSLNTDSC-----IMALRNC-FARR-GVPIQIISDRGTNFIGA EKELK-K-------ALELVDQD-A----------------------MI---KKFTTSSTS ----WTFNPPATPHMGGSWERLIQSVKKVLYDIQP------H-RVP----RDEVL----- --KNT-----LIEVENIVNSRP--------LTH------------V-------------- ----------------------PI-------------DD--------------------- ----------- >632/1-543 ---PTKREVLRTLMMLFDPLGLIAHFTMLLKILLQE-IWRT-S----------V------ -GWDD-I-IED--AQFSKWLEWLKALPRIP---D-IRIP--RCY--R------------- -TLTSLT-DGTDI-QLHT-FMDASEN-GFA-AVVYLR--FQE--GQ------TIEC-S-- LVGG---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQSCI-IGI-RLSETVLQS-- -L------S-VKI---SRR---FF---------WT------------------------- -----------------------------------RVWYLPMFPV-------WNPN-K-P GKT-RLVWDAAAS-A-HG---VSLNSVLLKGPDQL--SSLLTILIKFR---EFKI--AVC ADIREMYHQVLMRED--DQHCQR-----F------FWKHK---E-TD---------SDPS VYIMKVQSFGACCSPSIAQHV-KNHN------------A----KQF-AREY--P-AAVQA I-TDC--HYVDDM-LMSVE-T---ESEAVQVSKDVR-EI-HQRG-------GFEMH-NWL SNSS-QV-LQAL--QE---PTVK---EKDFSS-----------------------SSE-T MT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TLPFVYMGVDYFGPLF-------------------------------------------- ----------------------------VV--VG-R-----R-TE-----KR-WGV---L -GTCLT--TRAICIEIAHTLSTDSC-----VMALRNI-MVRR-GVPAVIYSDRGTNFQGA SKEVQ-Q-------EMYSL-QD-R----------------------LA---AEFTTSKTE ----WVFIPPASPHMGGAWERMIRTVKQNLNKLQF------D-RFX----SDEVL----- --RNT-----MMEVENIVNSRP--------LTE------------I-------------- ------------------------------------------------------------ ----------- >634/1-546 ---PTKRDVASKMAETFDPLGLISPIQVLMKRFIQK-----HE----------V------ -NWKD-P-IPK--HLLDDWQAIQASFIDRT-----ITVP--RRL---------------- ---T-TDFEYKEI-QLLI-FSDASQD-IYA-AAAYAY--FSYGDDR------PPVI-S-- LITS---------------------------KNKI-KPSKET-N---------------- --------------------------------WTIPKLELLGIE-IGS-NLASSIVKE-- -L------S---CKV-TNI---RL---------FT------------------------- ------------------------------------NYNMPHRAV-------IKE-SSNT TKV-RVVYDASSHAV-GQ---LSLNDVVHAGANMV--IPLFGILIRSR---FIKL--MIV GDLEKAFHQVQVQPE--FRNLTL-----F------LWLTD---L-NK----PITRDNI-C TKRFVRLPFGMSCSPNLLAST-IVHF------------L-------VHNPD--E-LN-ND I-LDN--LYVDNI-LIGTN-D---LALIMNRITRLK-QI-FSHM-------KMNIR-EFV VNHD-ES-MEKIDPKDR--V---------------------------------------- SARTI-----------------KL--LG-------------------------------- -----MKW---------------------------------------------------- ----------------------------------------------------------TP STPFQNAGLDYMGPVE-------------------------------------------- ----------------------------YSKDDGVSTG------------KA-YVL---I -YTCFT--TRAAILRVVSDGSTERF-----IMALKTI-FHQV-GVPKMVYSDNAPAFILG GSILN-D-------DIST----------WEHH-----------SDPLT---SFMATQSIH ----FFRITPVSPWQGGMYERIVGLVKHQILKVCG--A-----DRF----DYFTL----- --SYI-----VSSAQAMVNNRP--------LMQ------------H-------------- ----------------------SR--------QPD--D-------M-------------- ----------- >635/1-542 ---PTRKQIASWVASNYDPMGLICPIVIQLRLLQSA-AC-EDE----------L------ -KWSQ-Q-IGE--KRYDMLEKAKAMFDDDL-----FEIP--RQI---------------- ---V-TNYEFNSV-ELVM-FSDASKH-HYG-IAAYLR--FAY-PDG------SFQS-K-- LIFA---------------------------KSRI-RPLRSGPE---------------- --------------------------------LTIPRMELIALE-LAS-NSAVTLAKE-- -L------H---QQL-KQV---TI---------FS------------------------- -----------------------------------S--FMPTSVV-------IKE-DSAF TKV-RIVNDASAHMK-GE---LSINDCIYAGPSLL--NQILGILLRAR---LGKY--LMI SDIAKAFHQVKIQKQ--YRNMTQ-----I------LWLRD---P-DI----PPTSANV-V PYRSTVLPFGISCSPFLLAIT-IMQY------------M-------DIYPN--P-LN-EI I-LKN--MYVDNV-IFVTN-E---KEELTKFYAQAK-ELFAKNM-------FMNLR-EFL VNSA-DV-MDKIPEKDR--A---------------------------------------- PSLLY-----------------KL--LG-------------------------------- -----HVW---------------------------------------------------- ----------------------------------------------------------ML VGPFKNIGIDYFGPLA-------------------------------------------- ----------------------------FK-LGQ-STG------------KV-WVM---L -VSCMV--TRAIHLEIVPDNSTHGF-----LQALHRF-VSRR-GAPEHILSDNAPAFKLG YSMIK-K-------DLIT----------LINT-----------SESLT---SFMAQHSIT ----PKLITPFSPWQGGSYERMVALVKNVVFKVLG--T-----TTL----PFLEL----- --ETL-----LIEVEGILNSRP--------VTP------------N-------------- ----------------------KI------------------------------------ ----------- >636/1-554 ---TTKRTILRFIASQYDPLGFLVPLIVPFKIFLQE-LWR-KN----------I------ -HWDQ-P-LDN--QLIETWNNLVVECPT-H---I-KEIP--RFT--I------------- ----D---LSQQI-TFHV-FTDASTV-AYA-AVVYAH--Q----N--------THT-S-- LLFA---------------------------KSRL-API--K-------G---------- --------------------------------MTIPKLELLAIL-IGV-RAAQFVIKQ-- -M------E-LENP---KV---VV---------WS------------------------- -------------------------------------S------------------DNTT TKV-RIVYDASAHLR-GR---KSLNDVLYRGPITL--PDLAGILIRLR---TMKI--III ADVEKAFLQLELLPT--ERDCTR-----F------LWVKD---I-QK----QVDRDNL-I CYRFKRVPFGVISSPFLLSAT-LNYH------------L------EHYET---E-TA-RE I-KKN--LYVDNI-ILSAS-H---EKEALNKYEETK-SI-FKDA-------SMNVR-EFL SNDQ-TF-NEQLPKSDR--AR--------------------------------------- MSQIK-----------------KI--LG-------------------------------- -----IKWNPHKDHIQITLNPWTEQTTTKRTILRFIASQYDPLGFLV------------- ----------------------------------------------------------TE SRTFGRIGLDYLGPIT-------------------------------------------- ----------------------------VKI--QLEKA------------KR-WIA---L -FTCFT--TRAVHLEMVDDLSAESF-----LTALRRF-VARR-GYPELILSDNATQFQAV FQAIK-T--------------Q-ES---QL-----------------S---NFLAEKGIK ----CKTITPRAPWSGGIYERLIGLTKRSLRRAIG--R-----RLL----KEGEL----- --ITL-----IIEVESILNTRP--------LTY------------V-------------- ----------------------NF------------------------------------ ----------- >637/1-556 ---STKREVLSDIGRLFDPLGFLGPVIAMAKMVMQD-VWRL-R----------L------ -DWDD-L-LPD--ELLCQWQHFREELPVIN---Q-KQKR--RCV--V------------- --RD-R-AS--WT-ELHG-FSDASKR-AYG-AVVYTK--CIAA-DG------TVEV-N-- LVAS---------------------------KSRV-APL-------K------------- ---P----------------------------MTIPRLELCGVK-LLA-ELVQKVTTS-- -M-T----I-D-F---DEI---NL---------WC------------------------- ------------------------------DG-----YYIPHHAV-------YKAS-SST TKT-RVVFDASAKSA-SG---VSLNDAVMVGPTVQ--SNLVEVIMRFC---GHQV--ALT ADVPKMYRQVCMHPD--DCKYQR-----I------LWCND---Q-NE----------M-K VFELQTVTYGIASSPYHATKA-LMQL------------V----EDD-GDQF--P-LASVV I-KKD--SYVDDF-LTGGQ-T---ARTVINKYQELS-AL-LDRG-------GFGVH-KFC SNSQ-EV-LAAMPEQLHEQQV------SFE---------------------------ESG INNTI-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------NP APVFSKVGIDYAGPFM-------------------------------------------- ----------------------------LK--LGGRSP---KVY------KA-YVV---V -FVCMA--VKAIHFEVVSNLSTDNF-----IAALHRF-VGRR-GLPSDIYSDNGTAFVGA NHELV-A-------LKQLFEDQ-QH------------------QHKVE---EFCAVKGIC ----WHFIPPRSPHFGGIWEAGVKSMKHHLKRVVG--E-----TKL----TFEEL----- --TTF-----LAQTEAILNSRP--------LVP------------V-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >64/1-550 ---PTKRNILSVTARLFDPLGLLCPLITRAKILLQE-LWRQ-K----------L------ -DWDE-S-VPM--NLHTSWNEFKQNLLAID---K-ISIP--RYI--C------------- --LS-G-YD--TV-QIHG-FADASSH-AYG-CCIYIR--TVAG-TN------RLS--R-- LLTA---------------------------KSRV-SPL-------K------------- ---T----------------------------KSIPRLELCAAH-LLA-KLWSQVSPL-- -LNK----L-E-L---ESI---NF---------WS------------------------- ------------------------------------HYYIPHQCV-------LRPD-SST TKL-RVVFDASSKTS-TS---ISLNETLMVGATIQ--RELYAILARFR---LHKY--ALT ADISKMYRQVNIANE--DRDFQL-----I------VWREK---S-TQ---------AL-Q TYRLNTVTYGTASAPFLAIRC-LFEL------------S----KIY-AESH--P-VASEV I-SSD--FYVDDM-LTGAN-S---IEELEVIRKEVT-KV-LELG-------GFHLA-KWA TNHP-SL-MSNQGSEKSLIFN--------------------------------------- TSESV-----------------KTSYLG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------RM ERPFLVCGVDFCGPFY-------------------------------------------- ----------------------------VSLK--VRGR---PPI------KT-YVA---V -FVCFS--SKAVHLELVVDLSTDSF-----LSVFKRF-VGRR-GLPEKVYSDNATNFVGA CNVLK-E-------LSEAFHRS-R--------------------DELS---GYAAQRGVE ----WCFIPPRSPHFGGLWEAAVKSAKTRLLRGVG--N-----AKL----TTDEL----- --STH-----LVEVEALLNSRP--------IAS------------P-------------- ----------------------GN--------DPN--D-------G-------------- ----------- >640/1-540 ---PTKKDVASRLAQTFDPLGLVIPILVQFKRLMQK-CW-LDG----------I------ -RWKD-R-LPK--ELLGEWQKVKEVFQDKT-----LTVP--RQL---------------- ---T-VRYDYDSV-RLMI-FSDASKD-MMA-ASVYVH--YSF-PDA------PPVV-S-- LLAA---------------------------KNKI-KSAQNE-S---------------- --------------------------------WTIPKLELFSIE-IGT-NMAVTAVNE-- -I------R---IPI-VEA---CF---------FT------------------------- ---------------------------------------IPHRVV-------VKM-SSLT TKL-RIVYDASSRKK-DE---LSLNQCVHAGPPML--QSIFGILIRAR---MYKF--IVI ADIEKAFHQVQMQPQ--FRDLTR-----F------LWLKD---I-TK----PATRDNT-E TLHFRKIPFGLTSSPFLLAAT-ILFF------------L-------LRNPH--K-LN-DM T-KDN--LYVDNC-LYHTN-D---KSEIPFLVKHAK-EI-FDMM-------PMNLR-EFI VNDP-VE-MENIPEKDR--A---------------------------------------- SALAI-----------------KV--LG-------------------------------- -----YLW---------------------------------------------------- ----------------------------------------------------------EP STPFSHCGLDYMGPIP-------------------------------------------- ----------------------------YTKDDG-SIG------------KS-YVL---V -YTCLV--TRGARLELVPDGSTERY-----IESLGII-FSRS-GFPQSLYSDNARTFQLG EKIIN-E-------DVIC----------GE-V-----------SESLT---SYLASHQID ----FVYITPLAPWQGGVYERVVKLVKNQLQKVLG--D-----NTL----DFHSL----- --RRV-----LAGAEAMVNSRP--------LVA------------H-------------- ----------------------PK--------R------------L-------------- ----------- >642/1-543 ---PTKRQVLRCVMTLFDPLGLLSPFIIHGKVLIQD-LWRV-G----------T------ -SWDE-Q-VNE--EIYAKWHRWVQMIGYIA---E-IRIP--RCY--F------------- -QNADQN-TYKSS-ELHV-FVDASEV-AYS-CAIYLR--ILDG-GA------ESHC-C-- LIAA---------------------------KSKV-APL--K-P---------------- --------------------------------WSIPRLELQGCV-LGV-RWSRFVKSE-- -H------N-ISI---SKM---VF---------WT------------------------- -------------------------------------WYLPVGAV-------MNPK-K-P GKV-RVIWDAAAK-V-NG---VSLNSKLLKGPDQL--TSLPAILFRFR---LYGV--AVT SDIQEMFHQIRIRAE--DRDSQR-----F------LWRAN---P-TE---------K-PT IYVMDVATFGSTCSPASAQFV-KNRN------------A----ELH-SELY--P-EAAKA I-VDD--HYVDDY-LASFS-S---WEQAAKVARDVR-FV-HGNG-------GFNLH-NWR SNSA-AV-LEAL--GEA----CLES-DKQISL-----------------------V-DGV KT--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------HH ERAFTYTGVDYFGPLI-------------------------------------------- ----------------------------VK--LG-R-----S-NV-----KR-WVA---L -FTCLT--VRAVHLEVAYSLSTESC-----ISCVRRF-VGRR-GPPSEFFSDNGTNFQGA DRVLR-Q-Q----------ISQ-G----------------------LS---TTFTSTNTK ----WNFIPPGAPHMGGAWERLVQSVKAAMQEA-Y--S---E-GKL----DDEGL----- --QTL-----VVEAERLVNSRP--------LTY------------L-------------- ----------------------PL-------------EA--------------------- ----------- >643/1-567 ----TKRXIHSDAACLFDPLGLVGPVIVQAKIFIQQ-LWRL-K----------C------ -GWDD-P-LDQ--SIQGMWREFRQNLMALE---T-LTIP--RWV--G------------- --FSND-CV--SV-QLHG-FSDASTI-AYG-ACLYLR--CVAS-NG------TVTV-R-- LITS---------------------------KSRV-APL--E-NSEQ------------- ---KKKK-------------------------MTIPRLELSAAL-LLS-HLYEKF-IQ-- -V-K----T---I---PVA---XF---------WT------------------------- ------------------------------ITSEGPVYYLPHHAV-------LRPD-STT TKL-RVVFDASCRTS-TG---ISLNEALMVGPVVQ--DPLLAILLRFR---LRRI--AVV SDVAKMYRMVLTQQK--DHPLHK-----I------VWRDS---K-EQ---------PL-K FFELTTVTYGTASAPYLATRC-LKKL------------G----EDC-VLTH--P-IASEV I-QHD--FYVDDM-LSGAD-S---IEEAKTLVKQVS-EV-SDSA-------GFNLR-KWN SNSK-EV-LRSIPKYLRDERS--M-L-DFD---------------------------S-- SXAXV-----------------KT--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------TP SAPFLKVGVDYCGPFH-------------------------------------------- ----------------------------ISYP--NRKS---SPV------KC-YVA---V -FVCLA--VKAIHLELVMDLTTQAF-----IAALRRF-VARR-GRPQIIMCDNATTFVGA NRELK-E-------LLKQLKSS-QF------------------QEPVI---KEAANDGIE ----FKFIPPRTPNFGGLWEAQVKSFKTHFKKAVG--L-----RTL----KVEEM----- --LTA-----LAQIEAVLNSRP--------MTA------------M-------------- ----------------------SS--------DPA--D-------Y-------------- ----------- >646/1-536 ---YTRRGVLSTINRLYDPLGFVAPVTIQGKAILRE-LTAV-S----------G------ -DWDA-P-LPQ--KMEDAWTLWRVSLSELA---N-FSIP--RVY--T------------- -EISTST--AMRR-ELCV-FADASIK-AIA-AVSYLK--VTDD-EG------KNHI-G-- FVMG---------------------------KAKL-APR--P-E---------------- --------------------------------HTVPRLELCAAV-LAV-ELADLISVN-- -L------D-LQF---DAV---TY---------YT------------------------- -------------------------------------WYLPTFGV-------YHPK-K-V NQI-RVVFDSSAQ-H-NA---ISLNDVLLTGPDLN--NTLVGVMMRFR---KEAI--AFT ADIEQMFYCFLVREE--DRDFLR-----F------LWFQD---NDTS---------KDIV DYRMRVHVFGNKPSPAVAIHC-LHKS------------V----QID-NFHV--DSEVKQF V-MRD--FYVDDG-LKSLP-T---VEATISLLKKTQ-EV-LSKS-------NLRLH-KIA ANSK-KV-MEAF-------PSTDH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SE DPPFTNVGLDVFGPWN-------------------------------------------- ----------------------------VS--SR-RTRGGLL-YS-----KR-WAV---I -FTCMS--IRAVHIEVIESLDTSSF-----INALRRF-LAVR-GPVKHIRSDRGTNFVGA CKELQ-I-------PSN-IDSK-V----------------------VK---TYLSDQGCT ----WTFNPPHASHCGGSWERMIGLARRILDSMFL--QL--KD-KL----THEVL----- --VTF-----MAEVTAIINARP--------L--------------V-------------- ----------------------PV-------------TTDPHES---------------- ----------- >647/1-561 -----RRDVVSEIFRIFDPLGLFSPVVMKAKIFMQH-LTKE-G----------Y------ -EYKD-D-LPA--HLQEEWKRYREELKVLN---T-IKVP--RHV--Y------------- --LGKT-PV--TA-EIHT-FVDASEK-AYG-AAVYIR--ATYK-DK------QRTI-Q-- LLCA---------------------------KSHL-API--N-T---------------- --------------------------------ITLPRLELKAAV-LGA-QLTSKVKED-- -L-A----M---K---NAST--FY---------WS------------------------- -----------------------------------ARYFIPHHCV-------LKPE-STT TKL-RVVFDASAVTS-SG---KSLNDLLHKGPTVQ--NSIFSILLRFR---TYKY--VFT ADIEKMYRQIWINPE--DQYFQT-----I------VWRNN---P-SE---------DL-R YYRLKTVTYGTKAAPYLATKC-LQHI------------A----QKG-RKEY--P--NAAA L-END--FYVDDC-LTGAE-T---IPEALQRQQQLN-KL-LQNS-------GFKLR-KWC TNNS-QV-LQGVPREDITSNVQLE-ETSYE------------------------------ -DYTI-----------------KT--LG-------------------------------- -----ITWTPTTD----------------------------------------------- ----------------------------------------------------------TQ ARPFFNSGVDYCGPFK-------------------------------------------- ----------------------------IHYK--VRGK---KPS------TA-YIA---I -FCCFT--TKAVHLELVSDLTTEAF-----LAALRRF-IARR-GKCQTLHCDNATNFVGA KNKLQ-E-------LQEAIFSD-NA------------------KTQIL---QECNNKGVQ ----FKFIPPRAPHFGGLWEAAVKSAKHLLLKNVT--T-----ADL----TYEEL----- --ETV-----IVEIEAILNSRP--------LTP------------L-------------- ----------------------SD--------DPN--D-------V-------------- ----------- >648/1-545 ---PTKRQLLSLVMSVFDPLGLVAPFVIHGKTIIQE-VWRS-G----------I------ -GWDE-Q-LPA--DIVPRWEQYITLLQSLD---N-VRIP--RCY--F------------- -PAYSMG-AYEST-ELHV-FVDASSA-AYA-AVAYFR--IVD--NG------VIRC-S-- LVSA---------------------------KTKV-APM--K-L---------------- --------------------------------LSVPRLELQAAV-IGT-RLLKAITTS-- -H------T-LQI---XRK---VM---------WS------------------------- -------------------------------------WYLPLGVV-------VNPK-K-P GKV-RVVWDAAAA-V-QG---VSLNSVLLRGPDLL--TSLQAVLSRFR---QKEV--AIS GDIMEMFHQVLITRQ--DRSAQW-----F------LWRDQ---P-SD---------T-IQ VFVMDVAIFGATCSPSSTQYV-KNLN------------A----KEH-ATEF--P-KAAVA I-TDN--HYVDDY-LDSVD-T---VEEAVQLAVDVK-EV-HEKX-------GFLVR-HWM SNSS-EV-LQTI--GE-QNTK----AIKSFTM-----------------------D-KGS NM--E-----------------RX--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------AY VRAFSFTGLDYFGPIT-------------------------------------------- ----------------------------VR--FG-R-----G-SA-----KR-WVA---L -FTCLG--TRAVHLEVVYSLSTESC-----KLAIRRF-ISRR-GAPQEIYSDQGTNFQGA NAELK-L-Q------MRR-VNQ-D----------------------LA---ETFTNAQTQ ----WMFNPPYAPHMGGIWERLVRSVKAGLSS-MS--L---S-RNP----DEETL----- --ITA-----VVEVESIVNSRP--------LTY------------L-------------- ----------------------PI-------------DS--------------------- ----------- >649/1-575 ---MTKRQLASEVLRLYDPLGIMQPIIITAKILLQG-MWKT-R----------L------ -KWED-H-IPD--ETLHEWQQLKKTLPKLA---E-LEFP--RQA--I------------- -PSNAT-----DL-ELHG-FSDASTR-AYG-GAIYAF--ATDS-NG------NKTM-N-- LLCA---------------------------KARV-VPL-------KDLKVTSEKDTSTE PTDD----------------------------LTLPRKELIGAK-LLA-ELMNRVISI-- -I------P-QHI---DKV---HY---------WC------------------------- --------------------------------------FIPHSCV-------IKPD-STS TKL-RVVFDASAKSS-NG---YSLNDLQLSEPAAQ--RDLFELLLDFR---CHDK--VVT ADIAKMYRQVNVHEQ--DSWLQC-----I------LWRDN---P-SH---------KI-Q AYRLKTVTYGEAAASFLACRA-LHQV------------G----EEI-RPQQ--P-NIAKI I-QQC--FYVDNL-MMGGD-S---AEVLLNQRKAVE-AA-LIKR-------GFPLR-KWA SNDP-SI-ISDVATEDLEKEI------------------------------------HVG DHDII-----------------KT--LG-------------------------------- -----VAW---------------------------------------------------- ----------------------------------------------------------NP STAFTHTGVDLCGPFQ-------------------------------------------- ----------------------------VLPS--QRAK---TRL------TV-YAC---L -FVCFS--TKAVHIEVVENQSTAAF-----IAAMIRF-VSLR-GRPEVVYSDNGRNFVGA SRELT-E-------LRKIYNNE-VF------------------QNEIV---GIAAEQGIN ----FSFIPPRSPNFGGLWEANIKVAKKLFTAAAR--G-----ASF----NILEI----- --QTV-----FYQIAAIMNSRP--------LTS------------V-------------- ----------------------LSNVGAPEPLTPG--H-------F-------------- ----------- >65/1-572 ---FTKRRILSLIATLFDPLGLIGATTVSAKIFMQQ-LWTL-Q----------D-ENGNR LDWDS-P-VPQ--TVGEAWRKFHEKLPLLN---E-VRVN--RCV--I------------- --IP-N-AV--SV-ELHC-FSDASEK-AYG-GCVYVR--SQDL-EG------TVQV-R-- LLSS---------------------------RSKV-APL-------R------------- ---N----------------------------QSIPRLELCGAL-LVS-QLFEKVKNS-- -T-R----L-S-----VPT---HF---------WT------------------------- ------------------------------EEETVKRCYLPHHPV-------VKEA-STT TKV-RVVFDASCKTS-TG---VSLNDALLVGPVVQ--EDLRSIILRSR---TKQI--LLV SDVEKMFRQILTTPE--DRPLQS-----I------LYRFS---P-NE---------EV-A VFELNTVTYGTKPAPFLATRT-LQQL------------A----ADE-ELNF--P-LAARA I-RED--VYMDDV-ITGTD-D---VDTAICLRNQLS-DM-MERG-------GFKLR-KWS CNIP-AV-LDGLPAENLAI-P-DG-V-NLD---------------------------P-- -D-QV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TA SRPFTKTGVDYFGPVY-------------------------------------------- ----------------------------IRPA--PRRT---A-V------KA-YVA---V -FICFC--TKAVHLELVSDLSTERF-----LQALRRF-VARR-GRPSDMYSDNGTNFVGA KNKLT-E-------LFSLLKDR-EH------------------HERIT---SELAQNGIQ ----WHFNPPSAPHFGGLWEAAVRSAKNHLLKVIG--E-----SVV----SSEDF----- --STL-----LVQVEACLNSRP--------LTP------------M-------------- ----------------------SD--------DPD--D-------LEPLTPAHF------ ----------- >650/1-551 -----KRALASHISSLLDPLGFACPTIAKAKMKLQT-LWRL-Q----------L------ -DWDS-P-VPD--GFAQDWEEFKQKLSGFD---Q-LRIP--RHV--F------------- --RPNY-LR--L--ELHG-FSDASQL-GYG-ACVYIR--SIHD-QN------QYTV-R-- LLVA---------------------------KSKV-API--N-I---------------- --------------------------------KTIPRLELCAAV-LLS-KLLGQVLEN-- -F-N----Y---D---AAI---NL---------WT------------------------- ---------------------------------------LPHHAV-------MKLD-SST TKL-RTVFDASCRSK-SG---LSLNDVLLPGPTIQ--DSLVKIIMRFR---FHQF--VVS ADIEKMFRQILVHPS--DQPLQR-----I------VWRDD---P-NS---------PL-K TFQLCTVTYGTNSAPFLSTRV-LQKL------------A----DDE-ERQY--P-LAAPA L-CND--FYVDNL-LSGSD-D---ENSLAVTCEQLI-AM-LASA-------GITLR-QWS SNSQ-TL-LDTIPPELRXTSA--L-R-DL----------------------------D-- HEASV-----------------TT--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------NQ AHPFENVGVDLAGPIY-------------------------------------------- ----------------------------VRTTLRNTRS---PSI------KA-YIV---V -YVCLA--TKAVHLDLVTDLTSEAF-----IASLRRF-SGRR-GIPAHIYCDNGTNFVGA HRELK-E-------LRKLFNSQ-HH------------------QEAVA---KACADDGSH ----FHFIPPRSPTFGGIWEACVKSVKQLLRRILG--N-----AHL----TEIQL----- --QTA-----LIQIEAQLNSRP--------ITP------------L-------------- ----------------------PA--------SPS--D-------E-------------- ----------- >651/1-551 ---PTKREVVKVVMTLFDPLGLISFFLVHGKILIQD-IWAR-G----------T------ -DWDE-A-IPS--DLYARWLQWTSLFPALE---Q-LRIP--RCY--F------------- -KSARWD-KLDNL-QIHV-FCDASEA-AYS-CVAYLR--LEE--EN------NMQV-A-- LIGS---------------------------KTKV-APL--K-T---------------- --------------------------------LSIPRLELNAAV-LGA-RLLETFQNY-- -H------R-LPI---SRR---VL---------WS------------------------- -------------------------------------WYLPLGIV-------TNPK-K-P QKI-RLIWDAAAK-V-DG---CSFNEKLLKGPDLL--TPLPKVLCQFR---QFPV--AIS GDLMEMFHQIRIRSP--DCQSQR-----F------VFREQ---P-SN---------Y-PC VYIMDVATFGSTCSPASAQYV-KNKN------------A----LEF-AEKF--P-RATDA I-VQK--HYVDDY-LDSFR-T---VEEAIDVVNEVK-LV-HSKG-------GFTLR-HFF SNVP-EV-LHGI--GEV----TKEE-SKNLLL-----------------------E-RGE NS--E-----------------SV--LG-------------------------------- -----MKWLPTED----------------------------------------------- ----------------------------------------------------------PF VRPFTFVGLDYFGPVS-------------------------------------------- ----------------------------VR--VG-R-----S-LA-----KR-WIA---L -FTCLT--IRAVHMEVVHSLSTESC-----IMAIRRF-ISRR-GPPKEFYTDNGTCFQGA SRELK-E-E------IEN-RNE-T----------------------LA---STFTSTNTS ----WKFIPPSAPHMGGVWERLVRSVKVATGAVLD--A---A-RKP----DDETL----- --ETV-----LLEAEAMINCRP--------LTF------------V-------------- ----------------------PL-------------ES--------------------- ----------- >652/1-584 ----TKRQILSVVAMLFDPLGLVGAVVTSAKVLMQQ-LWTL-I----------G-KDGQR LNWDQ-P-VPS--TVGETFRKYYDQLPLLN---E-LRMK--RCV--V------------- --MP-N-AV--SV-QIHC-FTDASEK-AFG-CCIYVR--STNS-DG------KVML-E-- LLSS---------------------------KSKV-APL-------K------------- ---T----------------------------QTIPRLELCGAL-LGA-QLFQKVRDS-- -I-K----M-E-----FQA---YF---------WT------------------------- ------------------------------NEDSTNRCYLPHHPV-------VKEA-STT TKV-RVVFNASCKTS-TG---FSLNDCLLCGPTVQ--EDLRSIILRYR---TKQI--MLV ADVEKMFRQILLRQE--DRPLQS-----I------LWRSS---T-AA---------NI-S VYELCTVTYGTKSAPFLATRT-LNQL------------A----LDE-EHRF--P-LAAKA I-YED--TYVDDV-LTGAD-N---IEEAKELRCQLE-KL-AECG-------GLRLR-KWA SNCF-EV-LEGISEENLAIQDTDS-V-SLD---------------------------P-- -DPSV-----------------KT--LG-------------------------------- -----LSWIPKTDVFRFEFKFPVIVL---------------------------------- ----------------------------------------------------------TV SRPFLKTGVDFFGPIY-------------------------------------------- ----------------------------VRXA--PRRP---S-V------KA-YVA---V -FICLC--TKAVHMELVTDLSTDRF-----LQALRRF-VARR-GRCAVLYSDNGTNFVGA RNKLL-E-------LFKLLSED-DH------------------KEAVA---KFCCTEGIQ ----WSFIPPGSPHFGGIXESAVRSAKHHLLKLLG--E-----NPE----SPEDL----- --ATL-----LTXVEACLNSRP--------LTA------------L-------------- ----------------------SD--------DPN--D-------M-------------- ----------- >653/1-571 ---PTKRQVLRAVMKLYDPLGFVAHFVVHGKILMQE-IWRS-G----------T------ -NWDE-P-IAE--HLRELWTKWIKLYESIN---E-VQIP--RCF--F------------- -GDFQPQ-AIDGI-EIHV-FTDASIA-ACA-CVAYLR--MLH--QG------GSWC-S-- MVAA---------------------------KTKV-APL--R-P---------------- --------------------------------LSVPRLELQAAL-MGS-RLLQRICTA-- -L------T-LNI---RKR---FL---------WT------------------------- -------------------------------------WYLPLGIV-------TSPK-Q-P NKI-RMVWDAAAK-V-GG---ASFNDMLLKGPDLL--VPLVDVLLRFR---EGKI--AVC SDIREMFLRILIRDE--DRXSQC-----F------LWRNN---P-KE---------D-VQ VYMINVAMFGATSSPCSAQFA-KNKN------------A----LEY-AEQY--P-RAVRA I-VKG--HYVDDF-LDSVN-S---VDEAVQLVQQVQ-HI-HASA-------GFEFG-KIL SNSP-EV-LERL--GE-----TSPSTVKSLNL-----------------------D-KDA VH--E-----------------RV--LG-------------------------------- -----VMWVPIADHFTFDRTGLQEVLGNTL------------------------------ ----------------------------------------------------------PF IRPFTFVGVDYMGPFL-------------------------------------------- ----------------------------VK--VG-R-----S-SV-----KR-WIC---L -FTCLT--IRAIHLELVHSLSTTSC-----VMAFRRF-VARR-GAPSEIFSDNGTNFVGA NRQLS-E-EKR---KIER-INE-D----------------------CS---STFTNANTQ ----WHFNVPVAPHMGGPWERMVRSVKVAMQAISD--S---A-RYP----SDEVM----- --ETI-----MLEAEAIVNSRP--------LTY------------V-------------- ----------------------PL-------------ED--------------------- ----------- >654/1-562 ----TKRLVLSEAARLFDPLGLLGPVVLRSKLFMQE-LWKS-K----------V------ -SWDI-P-LND--HQQQFWKSFRRDLEILD---T-FTVP--RWA--A------------- --PHLD-AA--NL-ELHG-FSDASES-AYG-ACIYIR--TISP-NG------IVSV-N-- LLTA---------------------------KSKV-APK--G-TEKL------------- ---DPS--------------------------IRLPRLELCGAL-LLS-HLFEKVESS-- -L-Q----N---Q---VRP---FF---------WT------------------------- -----------------------------------KTYYMPHHCI-------VRPE-NVT TKL-RVVFDASCASD-TG---VSLNDALIVGPVVQ--DELYSIILRFR---MSRF--VIV ADLEKMYRQVLVSPA--DRPLQR-----I------VFRSS---P-SE---------PL-Q TYELLTVTYGTASAPYLATRC-LQQL------------A----SDG-ESTH--P-KAAEA L-SKD--FYIDDL-LGGVA-S---EEGGITLCRELI-DL-LSSA-------GFKLH-KWA SNSP-KI-LQNIPPELREDRS--L-L-ELD---------------------------S-- STSPV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TP TLPFLNTGVDFCGPFY-------------------------------------------- ----------------------------LRPP--TRRA---APL------KS-FVA---V -FVCLS--TKAIHLELVSNLSADSF-----IASLKRF-AARR-GVPQTIYCDNATNFVGA RRTLN-E-------FLHLFRTQ-QN------------------RLDVT---RQCSAEGIQ ----FSFIPPRSPHFGGIWEAAVKSLKTHLRRTLA--N-----ALV----STEQF----- --QTL-----ITQIEALLNSRP--------LTQ------------L-------------- ----------------------SN--------SPE--D-------L-------------- ----------- >655/1-574 ---PTKRSILSGISKHFDPLGITAPVVIRAKMLLQE-LWLQ-P----------C------ -GWDD-E-VSD--TINEKWQSYCSDLVKLS---T-YTVX--RYA--F------------- --LP-N-SA---V-EIHT-FADASEQ-AYG-ACSYAR--CTDS-NG------QIHV-Q-- LIAA---------------------------KSRV-APL-------K------------- ---R----------------------------LSIPRLELSAAV-LAA-RLHAKIIEA-- -L-D----M-P-I---KSS---HF---------WS------------------------- ------------------------------EPEPTQTSYIPHHPV-------VKES-STT TKV-RVVFNGSVRST-TG---FSLNDALQVGPVVQ--DELLTLVLRFR---KYPI--ALV ADIEKMYRQVLVDPR--DTPLQR-----I------FWRFQ---P-NG---------PI-E TCELMTVTYGLASSSFLATRT-LKQL------------Y----QDE-GENY--P-LGGPA L-VKS--FYVDDY-IGGAQ-S---VNEAIQTREELD-EL-LTKG-------GFKLR-KWS SNDP-RV-LADLDPSQVETQS--F-L-KLD---------------------------T-- -EKPM-----------------KA--LG-------------------------------- -----VGWEPLTDKLRFDITPI-------------------------------------- ----------------------------------------------------------TP SRPFTVTGVDYAGPLY-------------------------------------------- ----------------------------LKPP--HKRA---ATI------KA-YIS---I -FVCFA--TKAVHIELVSNLSTAAF-----IAALRRF-VSRR-GRPVHMYSDNGKNFEGA RNELQ-Q-------LHQMLHSE-QS------------------SGDIA---TICATEGIQ ----WHMIPPKAPHFGGLWEAAVKTAKKHLYRQLG--N-----ITL----SYEDM----- --TTI-----LTQIEACMNSRP--------LTP------------M-------------- ----------------------TE--------TPD--D-------L-------------- ----------- >656/1-569 ----TKRVMVSDAAKLFDPYGLIGPVIVIAKLNLQD-VWSM-Q----------K------ -NWDE-P-LAE--VLQQIWLDYRASLEELR---N-LSVP--RCV--I------------- --PVIY-VV--SR-QLHG-FCDASEK-AYG-ANIYLR--TETS-DG------KAKT-S-- LLAS---------------------------KSRV-APL--G-NPKK------------- ---KKQQK------------------------TNLPRLELNGGL-LLA-HLLVKVIVA-- -T-N----F---D---GEV---FL---------WT------------------------- ------------------------------SSSSLPTYFLPHHCV-------LRPE-STT TKL-RVVFDASCATD-TG---VSLNDCLMVGPVVQ--QDLFSIVLRFR---WYRY--AMV SDVEKMYRQVLVHPA--DRPLQM-----I------VWRDS---P-HE---------PL-R FYQLTTVTYGTSCAPYLATRC-LAEL------------A----KVG-ETTY--P-EAAKV V-ATD--FYMDDL-LTGVN-D---VAAGQQLCSHLQ-NL-LGSA-------GFCLR-KWS SNCP-SI-LENLPKELRDERA--L-F-EFN---------------------------S-- PTGPI-----------------KT--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------TP TLPFLSTGVDLCGPFK-------------------------------------------- ----------------------------YRHP--ELRN---KFT------IC-YVA---V -FVCLT--TKAVHVEMVGDLTTGAF-----LASLRRF-VARR-GKPRLIECDNAQNFKGA LNELV-V-------LREQFNSQ-QH------------------QHDVV---RAAAEDGIE ----FKFIPPRSPNFGGLWEAAVKSLKTHLRTVLG--N-----SVL----TAEQL----- --NTL-----LTQVESCLNSRP--------LTP------------L-------------- ----------------------SN--------DPQ--D-------F-------------- ----------- >657/1-547 ---PTKREVLRVAMSLFDPLGLITFYLIHGRILMQN-IWAS-K----------I------ -NWDD-V-IDN--ELCERWRLWIGYLPQLD---L-LRIP--RCY--F------------- -AGGNQQ-TYSTL-QIHV-FVXASEA-AFS-SVIYFR--VET--VS------GXXX-A-- LVSA---------------------------KSKV-APL--K-M---------------- --------------------------------LXIXRLELQAAV-LGT-RLLNSXISM-- -H------N-LXV---TRR---VL---------XT------------------------- -----------------------------------KCWYLPLGVV-------VNPR-K-- NKV-RLIMDARAT-V-NG---VSFNSSLLKGPDML--VSLPSVLSHFR---LFQY--ALA ADIKEMFHRIKIREE--DRQFQR-----F------LWRDR---P-HL---------E-PS TFVMDVAIFGSTCSPSSAQYV-KNQN------------A----REF-ASEF--P-RAAEA I-TRH--HYVDDY-LDSFG-T---IEEAVTVGREVK-EI-HARG-------GFEIR-NFL SNKA-EL-AESV--GS-----QSTAMEKLFPA-----------------------G-NEE YA--E-----------------SV--LG-------------------------------- -----MSW---------------------------------------------------- ----------------------------------------------------------PF FRPFTFVGLDYFGPIL-------------------------------------------- ----------------------------AK--QG-R-----C-NV-----KR-WIA---L -FTCLS--IRAVHLEVLHALSTESC-----VLAIRRF-VTRR-GSPAEIFSDNGTNFHGA NNKLK-K-Q------IEE-RNR-T----------------------LA---AIFTNANTK ----WSFNPPGAPHMGGVWERMVRSVKVAIGTFTE--A---T-RNP----DDETL----- --ETV-----IIEAEGIINSRP--------LTY------------I-------------- ----------------------PV-------------ES--------------------- ----------- >658/1-552 ---PTKRIILSCVMGFFDPLGLLTPFTVHGKTLVQD-LWRT-G----------C------ -TWDD-E-VND--DCWMKWKRWIGLLPEVE---A-IRIP--RCY--F------------- -GDAPWS-SVQSI-ELHI-FTDASEY-AYG-CVGYLR--TVIE-GD-------VRC-C-- LVMS---------------------------RSKV-APL--K-R---------------- --------------------------------QSIPRLELMAAV-LGA-RMLHTILNT-- -H------S-IKF---QRH---IL---------WT------------------------- ---------------G---------------TDPRKVWYLPLNVV-------LNPR-K-P GKI-RLVWDAAAS-V-DG---VSLNSQLITGPDML--TPLISVVSRFR---EHRI--AFG ADIREMYHQLRIIEA--DKQAQR-----F------LFRMN---K-ED---------P-IN IYVMDVATFGSTCSPCSAQYV-KNQN------------A----MEY-ATTY--S-DAAAA I-IDG--HYVDDY-FDSVE-T---IEEAIQRAKEVS-FI-HAQG-------GFELR-NWI SNAP-EV-LHGL--GE-----IKAAQPVHFGR-----------------------A-KES DS--E-----------------RV--LG-------------------------------- -----IIW---------------------------------------------------- ----------------------------------------------------------PQ LRPFNAVGVDYLGPVE-------------------------------------------- ----------------------------VT--VG-R-----R-IE-----KR-WIA---L -FTCLS--VRAVHLEVAHSLSSQSC-----LMAIRRF-ICRR-GCPENFFSDNGTNFKGA SKEL-----------LKR-VEV-D----------------------SA---EAVSSSTTK ----WNFNPPGAPHMGGVWERMVRSVKEAMLA-LN--D---G-RKL----TDEIL----- --MTT-----LGEAEDMINTRP--------LTY------------K----SLE------- ----------------------PS-------------EV--------------------- ----------- >659/1-558 ---FTKRQMISDSSKLFDPFGWLAPVLVKIKILYQQ-LWLF-D----------V------ -NWDD-S-LPP--AVKAEWQEVRSTLHLLE---N-MRIP--R-Y--L------------- -SPFRGR--I----QLHG-FSDASEQ-AYA-AVVYAR--SVNA-NG------NISV-V-- LIAA---------------------------KSRV-API--K-Q---------------- --------------------------------VSLPRLELCGAW-LLA-LLMERITEA-- -L------S-HLA---IEH---WA---------WT------------------------- ---------------------------------------LPHHAV-------IKAD-SST TKL-RVVFDASCATS-TG---VSLNDRLRAGPNNN--ADLFSVALRFR---SHKV--VFC ADVAKMYRQVLVHPD--DRDYQR-----I------VFREE---P-DQ---------PI-K HYRLCTVTYGTKTAPYLAIES-MRAA------------A----KAY-DDVY--P-QAVER I-KRD--FYVDDF-LSGAD-D---TNEATCLKQQVV-EI-LSSA-------GFELR-KWT SNNQ-EL-LQEQRTDESAPVLMKF-SEQGE------------------------------ ---AV-----------------KA--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------LA TRPFSHVGVDYAGPVK-------------------------------------------- ----------------------------LKAA--CVRG---VKVT-----KG-YIA---V -FVCLS--TKAVHLEVASDLSTNTF-----ISVLKRF-VSRR-GYPVEIWSDNGTNFVGA DRVLQ-E-------FVEQIQSN-GK--------------------EAA---RFLSNLGIK ----WTFNPPSAPHMGGIWEAAVKSTKKHLVAELG--D-----EAI----TFEDL----- --STI-----LCQVEACLNSRP--------LCA------------L-------------- ----------------------SS--------NPD--S-------VEALTPGHF------ ----------- >66/1-539 ---CTRRGVLSKVCSVYDPLGFLAPFTLTAKILLQE-LCRI-R----------C------ -GWDD-L-LPS--NLQRQWSLWLKELEKMA---D-FKMD--RCL--K------------- -PAGMDE--LTNV-QLHH-FADASTL-GYG-TVTYLR--METK-HD-------VHV-T-- FLLS---------------------------KARV-APL--K-S---------------- --------------------------------VTIPRLELTAAV-LAA-RVDKMLRAE-- -M------Q-FPL---VDS---VF---------WT------------------------- ---------------K---------------QDEGKVWYIPHHGV-------YHPK-K-- QTL-RVVFDCGAA-F-KG---TSLNDQLLQGPNLT--NSLLGVLVRFR---QEPI--AFM ADVKAMFHQVKVAEE--DTDFLR-----F------LWWPD---GDIN---------QDSV EYRMKVHLFGAVSSPSCACYA-LRRT------------A----EDN-KDDF--PEKVIDT I-HTN--FYMDDC-LKSVP-S---EEEAVLMIKDLT-DV-CLAG-------GFQLI-KWI SNSR-IV-LQSV-------PEEHRAQ------------------------------G--- ------------------------------------------------------------ ------------------------------------------------I----------- ----------------------------------------------------------PD LPPFSNVGVDYFGPVE-------------------------------------------- ----------------------------VK--RG-R-----S-IV-----KR-YGV---I -FTCMA--SRAVHLEVAYSLDTDSC-----INTLRRF-ICRR-GQVTQIRSDNGTNFVAA EKELK-E-------SLRSWNQN-K----------------------IQ---RAMLQKGVQ ----WSFNPPGGSHYGGIWERVIRMVKRILNSILH--Q---Q--IL----DDEGF----- --HTV-----LCEIEAILNDRP--------ITK------------L-------------- ----------------------SD-------------D--------PNDL---------- ----------- >660/1-563 ---WTRRCILSCIAKLFDPLGLISPVVVYAKIIMQQ-LALL-Q----------T------ -NWDD-P-VPI--QLENKWTEYYGQLNRLS---E-LRIE--RFA--F------------- --IP-Q-WV--DV-QIHC-FADASEL-AYG-TCLYVR--TIDQ-AG------NIYV-E-- MLSS---------------------------RSRV-APL-------K------------- ---R----------------------------LTLPRLELCAAK-EAA-NLHSKVIKA-- -L-D----L-G-Q---IRS---TF---------WS------------------------- ------------------------------HSKARKTFYLPHHAV-------LKES-STT TKV-RVVFDGSARTD-RG---YSLNDALLKGPIIQ--DELLSLLLRFR---KYEV--ALV GDVEKMYRQVRLHTD--DTPLQR-----I------FWRFS---T-VD---------PV-S EYELLTVTYGLTPSSFLSIRA-LHQL------------A----ADE-GTDF--P-VASAS L-VHD--FYVDDY-IGGAP-N---VNEAIQLRQDLT-RL-MSKG-------GFVLR-KWC SNRP-EV-LLDVPPDQLGTNL--S-I-TFQ-------------------------LNP-- -DEEI-----------------KT--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------RP SRPFSITGVDYCGPFY-------------------------------------------- ----------------------------LKPP--HRRA---APP------KA-YIS---V -FVCFA--TKAIHLEIVSDLSTTGF-----LAALHRF-VGHH-GIPLEIHSDNAKNFTGA KNELN-E-------LFNILNDK-SS------------------QERIG---NELSLQGIT ----WKFIPPRAPNFGGLWEAAVKSVKAALKKEIG--I-----HQL----SYESF----- --ATL-----LVQIAAALNSRP--------LVP------------L-------------- ----------------------SD--------DPS--D-------L-------------- ----------- >663/1-549 ---NTKRQLLSDASRLFDPFGWLAPVIVKIKIIFQL-LWLY-D----------L------ -LWDD-P-LPP--LPEADWNTIKQTLHLLE---R-IRVP--R-R--I------------- -PAFNGK--L----QLLG-FSDASES-AYS-AVVYGR--SADR-NG------KIHI-V-- LICA---------------------------KTKV-API--Q-Q---------------- --------------------------------ICVPKLELNGSW-LLA-ALMKRVSLA-- -L------C-HLE---LQH---FA---------FT------------------------- ------------------------------DKHPSECFYLPHHAV-------QKED-SST TKL-RVVFDGSCRTS-SG---VSLNDRLLIGPNNN--EDLYDVYCRFR---TYPV--VFV SDIEKMYRQVRVDKQ--DTDFQR-----I------VWRDD---P-DQ---------PV-Q HYRLTTVTYGTSSAAYLATES-LRQA------------A----RDN-AEKH--P-VAADR I-LKG--FYVDDL-MSGAD-T---VEEAQELAGQIT-TI-LGEA-------GFVLR-KWS SNAP-EL-LENIADSRQGPVPVEF-TN--------------------------------- ------------------------------------------------------------ -----VTA---------------------------------------------------- ----------------------------------------------------------TP ARAFVHVGVDYAGPIL-------------------------------------------- ----------------------------VKSG--NPRK---PHVT-----KG-YIA---V -FVCLC--TKAVHLEVAGDLSTKAF-----FGALKRF-IARR-GLCTEIWSDNGTNFVGA DRQMQ-E-------FFETDEFK-Q---------------------QAA---HFAANIGIK ----WTFIPPSAPHMGGLWEAAVKSAKTHLRKVLG--N-----ESA----TYEEL----- --YTI-----LTQIEACLNSRP--------LCA------------L-------------- ----------------------SN--------SPD--S-------C-------------- ----------- >664/1-552 ---PTKRQSLSTVMSTFDPLGFLAHFTVRGKILIQA-LWRA-K----------T------ -QWDQ-R-IPD--KMCVRWTQWTDQFKFLE---Q-IRIP--RCY--F------------- -PRRSVK-DIKTL-QLHI-FVDASED-AFS-CVAYFR--AEFE-DG-------IEV-A-- LVGG---------------------------KSKV-APL--K-A---------------- --------------------------------LSIPRLELMAAV-IGV-RLMNTIIFG-- -H------S-LRI---DKT---IF---------WC------------------------- ---------------E---------------ADPRRVWYLPLGVA-------LNPK-K-P SKV-RIFCDAAAK-V-DG---ISLNTMLLKGPDLL--TTLPAVLFGFR---ERQI--ALC ADIKEMFHQVQIRKE--DRHAQR-----L------LWREN---P-SL---------E-PD IFLMDVATFGSTCSPCSAQFV-KNLN------------A----AEH-AEKF--P-AAAEA I-QRK--HYVDDY-LDSAD-N---EEEAVKLALEVK-HV-HSLG-------GFHLR-NWL SNSE-AV-LARV--GD-NDSA----SEKNLQL-----------------------D-KGS TT--E-----------------RV--LG-------------------------------- -----LYW---------------------------------------------------- ----------------------------------------------------------AF ERPFSYVGVDYFGPVA-------------------------------------------- ----------------------------VR--VN-R-----T-TA-----KR-WVA---L -FTCLT--TRAVHLEVVHSLSAESC-----KMSFRRL-IARR-GAPVEIYSDCGTNFVGS SNELQ-K-E------MKV-VEE-K----------------------LA---ETFTNATTK ----WVFNPPASPHMGGAWERLVRSVKTALAA-MN--T---A-RLP----NEETL----- --ATL-----VAEAESIVNSRP--------LTW------------I-------------- ----------------------PL-------------EA--------------------- ----------- >665/1-549 ---PTKRIVLSFIMAQFDPIGLITPVTVRGKMLVQD-LWRT-G----------C------ -EWDE-R-IDA--VSEEKWRRWIKMMHKIG---S-FKLP--RSY--F------------- -GNSKLN-EIEDL-QLHI-FSDASET-AYG-CVAYFR--AIVR-GE-------VRC-A-- LVMS---------------------------RSKV-APL--K-Q---------------- --------------------------------ISIPRLELLAAV-LGA-RLARTVQEN-- -H------N-LKV---DKV---VY---------WT------------------------- ---------------E---------------TPISSVWYLPLNVV-------QNPR-K-P GKV-RLVWDAAAT-V-EG---TSLNSELLKGPDML--VPLPKVISCFR---EGPV--AFG GDIQEMYHQIRIRSD--DKQAQR-----F------LFRSN---P-MD---------V-PQ VYVMDVATFGATCSPCSAQFV-KNLN------------A----EHY-AAEY--P-EAVRA I-VKQ--HYVDDY-YNSVD-S---VEEAIQRAKEVK-LI-HSKG-------GFHIR-NXI SNSA-AF-MEEF--GE-----TNATETVYFNR-----------------------D-KGT EY--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PN LRPFSFVGVDYMGPFE-------------------------------------------- ----------------------------VT--VG-R-----H-RE-----KR-WVA---L -FTCLA--TRAVHLEVTYGLTTQSC-----LMAIYRF-IGRR-DWPIXFISDNGTNFQGA SKALF-R-S----------IDL-D----------------------CA---DEFTNARTK ----WTXNPPAAPHMGGVWERLVRSVKEALKA-LD--D---G-KRL----TDEIL----- --QTV-----IVEAEDMINSRP--------LTY------------V----AQES------ ------------------------------------------------------------ ----------- >666/1-537 ---PTKREVLRTLMAIFDPLGLLSNLLIFLKILLQE-IWRS-G----------I------ -SWDD-E-IPT--SLHEKWECWLKVLPSVH---N-VHVP--RCY--R------------- -LRTSIG-PQTNV-QLHT-FVDASEE-GYA-AVVYLR--FQQ--GS------CVEC-A-- IVAA---------------------------KSRV-API--K-F---------------- --------------------------------VSIPRLELQAAV-VGA-RLAKTVCSS-- -L------S-FKI---DEK---YF---------WT------------------------- -----------------------------------RVWYLPIFPV-------FNPN-K-P GKM-RIVWDAAAK-T-NG---VSLNSMMLTGPDQL--TSLLSVLIQFR---ENKI--AIC GDLREMYHQVHISKE--DQNCQR-----F------LWREN---P-AD---------AEPS TFVMQVMTFGACCSPSCAXYV-KNLN------------A----EKH-AGKY--P-AAAKA I-IKS--HYVDDM-LVSTE-T---EDDAIRLAXDVR-HV-HAQA-------GFEMR-NWI TNSX-GV-LSAL--QK---EKIN---EKSLNL-----------------------GSE-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF CRPFSFVGVDYFGPFI-------------------------------------------- ----------------------------VA--VG-R-----R-SE-----KR-WGV---L -VTCLT--TRAVYIEVAHSLSADSC-----IMAIRNF-MVRR-GVPNQIFSDRGTNFVAT NKELK-A-------ALADLDQE-R----------------------II---QEIVSPETE ----WCFIPPASPHMGGAWERLIQTVKRNLQQITP------Q-RLF----SDETL----- --RNL-----FVEIEGIINSRP--------LTH------------V-------------- ----------------------PA-------------DD--------------------- ----------- >668/1-612 ---PTKRQIMSDIARLFDPLGYLGPAVMIAKLVMQQ-LWKE-K----------F------ -HWDD-P-VPE--DVAKMWERFRSELCEIS---E-LKIP--RAV--A------------- --AAVD-VT--SY-ELHG-FADASMK-GYG-CSVYLR--SLKR-DG------TAEM-M-- LLCA---------------------------KSRV-APL-------K------------- ---ELNRQPKDDAELED---------------LTIPRLELCASK-LMV-EQVVKVLDA-- -V-E----L-D-I---SRV---VL---------WT------------------------- -------------------------------------NYLPHHCV-------LKPD-SAT TKL-RVVFDASAKSS-TG---LSLNDVMMTGPTVQ--RTLFDIVLRFR---CHKY--VFT ADVPKMYRQVEVHEK--DRKYQQ-----I------LWRDD---H-QQ---------PL-R TIELSTVTYGTAAAPFLATRA-LNQL------------A----LDE-RHDF--P-EASTS V-LNN--FYVDDV-LAGAD-D---LCQAKQLQQDMI-EM-LARG-------GFQLH-KWC ANHA-AL-LEEIPVENRAKTL------NFE---------------------------KND EGEVV-----------------KT--LG-------------------------------- -----LLWDPVSDVFKFSVKPFKKSTERPTKRQIMXDIARLFDPLGYLGPAV-------- ----------------------------------------------------------TE ALPFSRTGVDYAGPLL-------------------------------------------- ----------------------------LK--QGRMRS---P-V------KA-YIA---L -FVCMT--TKALHLELVTSLSAEAF-----LGALHRF-VGRR-GNVSVMRSDRGTNFVGG DRQLK-E-------LHELLKTQ-LL------------------ERKIA---DFCQVRGID ----WKFNPAKAPHQGGLWEAGVKSVKHHLNRTLK--E-----AYL----TYEEL----- --NTL-----LVQIEAILNSRP--------LCQ------------Q-------------- ----------------------SD--------DPC--D-------Y-------------- ----------- >669/1-522 ---PTKRILLSIVMSFFDPLGLWALFTIFGKIIIQD-LWRN-G----------C------ -PWDQ-V-LDE--TSAAKWFKWIALLPRVQ---A-MTVP--RCY--F------------- -LGVKLS-DYVNL-ELHV-FTDASEE-AYG-AVAYFR--IWVY-GK-------PKV-S-- LVTG---------------------------KAKV-APL--Q-Y---------------- --------------------------------MSIPRLELQAGT-LGA-RMAAAIKAN-- -H------T-LPI---RRT---VM---------HT------------------------- -------------------------------------WYLPLNVV-------KHPK-K-P EKV-RLVWDAAAS-V-RG---KSLNTELLKGPDLL--TSLPTVLSRFR---ERPI--AFG GDIAEMYHQLQIQPS--DKSAQR-----F------LYRPN---G-SN---------Q-PV IFVMDVATFGAACSPCSAQYI-KNRN------------A----EEY-SEQY--P-DAVEA I-VGS--HYVDDY-LDSTF-T---VGEAIKRASEVA-FI-HSKA-------GFQLR-KWV SNSP-EF-LQHF--GV-----QV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PQ LRPFSYVGVDYFGPVV-------------------------------------------- ----------------------------VT--IG-R-----R-TE-----KR-WIC---L -FTCLV--TRAIHMEVAHSLSSASC-----MMAIRRF-ICRR-GAPLEIFSDNGTNFQAA SKELA-Q-T------VKC-IEL-E----------------------CA---DIFTDARTR ----WNFNPPAAPHFGGVWERLVRSAKDALKA-LH--D---G-KKL----TDEIL----- --LTV-----LAEAEDMVNSRP--------LTY------------M-------------- ----------------------PQ-------------ES--------------------- ----------- >67/1-563 ---PTKRIVLSIVMAQFDPVGYLAPVTILGKMLIQD-LWRT-G----------C------ -QWDE-V-VDE--ASFGKWKRWTDILADVR---A-FKLP--RSY--F------------- -GSARSE-EVQDV-QLHI-FADASET-AYG-CVAYFR--AVVR-GE-------VMC-A-- LVMS---------------------------RAKV-APL--K-Q---------------- --------------------------------LSIPRLELLAAV-LGA-RMSQTVYEN-- -H------N-FHI---TKV---VF---------WI------------------------- ---------------E---------------TPQAAVWYLPLNVV-------VNPR-K-P GKV-RLVWDAAAS-V-NG---VSLNSELLKGPDML--VPLPRVICNFR---ERPV--AFG GDIQEMYHQIRIRTE--DKQAQR-----F------IFRGN---S-DD---------A-PQ VYVMDVATFGSTCSPSSAQFV-KNLN------------A----EQF-SDQY--P-EATVA I-VKR--HYVDDY-YDSVD-T---VEEAVQRANEVK-YI-HSRG-------GFHIR-NWV SNSG-VF-LENL--GE-----RSSESSVHFSL-----------------------D-KST EY--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PN LRAFSYVGVDYLGPYD-------------------------------------------- ----------------------------VT--VG-R-----R-TE-----KR-WIA---L -FTCMV--TRAVHLEVAHGLTTQSC-----LMAIHRF-IGRR-GWPIEFFSDNGTNLRGA SKEVV-E-A------AQG-IRD-D----------------------CA---DLLTNARTK ----WTFNPPAAPHMGGVWERLVRSVKEALRA-LD--D---G-RRL----TDEIL----- --QTA-----IVEAEDIINSRP--------LTY------------V----SQQSDEAEAL T---------------------PN-------------HF--------------------- ----------- >670/1-560 ---PTKQFILSTIARLYDPLGHIAPVVVTAKIIMQE-CWQL-K----------C------ -DWND-P-VPD--NIRIKWEKFFKELPEIR---S-YRID--RYA--L------------- --QPDS-----TY-QLHT-FCDASKD-AYG-ACCYIR--CEDR-HG------NVRV-T-- FLAS---------------------------KSRV-APL-------R------------- ---G----------------------------LNVPRLEANAAV-LGV-HLHFRVKQA-- -L-K----I-K-I---SDS---YF---------WT------------------------- ------------------------------EKDKTPSCYLPHHPV-------FKDS-STT TKV-RVVFDGSAATS-TG---LSLNQALCVGPVVQ--EDLLSLLLRFR---NYPV--ALV ADAAKMYRQVLVHPE--DRRLQR-----I------FXRFS---P-DS---------PI-Q TYELQTVTYGLAPSAYLATRS-LQQL------------A----QDE-GHEY--P-LGGPA L-ESN--FYVDDF-IGGAD-T---VEDAIRLRKELT-EL-LAKG-------GFEMR-KWT SNRL-EV-LRGLTQDQIGTQS--S-L-QFG---------------------------P-- -NEMV-----------------KA--LG-------------------------------- -----IGW---------------------------------------------------- ----------------------------------------------------------IP SRPFSVVGVDYAGPLY-------------------------------------------- ----------------------------LKPI--HKRA---APA------KA-YIC---L -FVCFA--TKAVHIELVGDLSTPAF-----LAALRRF-IGRR-GVPSHIHSDNGKNFEGA KNELA-R-------LYTMLTHD-AE------------------QEKIH---EFCTAEGIT ----WHLTPPKAPHFGGLWESAVKVAKKHLFRQLG--P-----SRL----SFEDM----- --CTV-----LTQIESHMNSRP--------LLP------------L-------------- ----------------------SE--------DPN--D-------L-------------- ----------- >671/1-538 ---PTKRSQYSDIAKLYDPIGLLGPVIFKAKVMMQK-LWEV-E----------V------ -EWDD-V-LP----DTEEWDTFRNQIAEMG---E-IEIP--RNV--I------------- -PHP-N-PL--QI-ELHG-FSDASML-GYG-ASVYAR--CVYS-RE------YSTV-R-- LLTS---------------------------KSRI-APS-------K------------- ---NAK--------------------------QTIPRLELDGGL-VLA-RLISNLTHI-- -L-S----I-P-F---TRI---VC---------WM------------------------- -------------------------------------------------------A-STT TKT-RVVFDASAGTT-SG---SSLNDHLYVGPALQ--RKLYDIVIRFR---FPQF--VFT ADMTQMFRQIRIRSE--DRKYQQ-----I------FWRRH---P-DE---------LV-K VYQLATVTYGTACAPFLATRT-LAQV------------C----KDE-IERF--P-LAAKA G-TDD--VYMDDL-LSGAD-T---LEEALVLQKEFV-AM-MKSA-------GFDLH-KWA SNHP-DL-LKSVPNADNEQDA------------------------------------FFK DQKTT-----------------RT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------EG VCPFLNAGVDFAGPMY-------------------------------------------- ----------------------------IRQH--NKRS--TVTY------KA-YVA---V -FLCFA--TRAIHLELVGDLTADAF-----IAALQRF-VSRR-GKPVKLFSDNGLNFVGS KNKLR-D-------LYELFRSQ-QL------------------KGKLD---DFCTKTSID ----WRMIPPNAPHFGGLWEAGVRSAKYHLKRITG--T-----ANM----NFEEF----- --TTV-----LARIEAVLNSRP--------ISP------------M-------------- ----------------------SE------------------------------------ ----------- >672/1-561 ----TKAKVLSDIAKLFDPLGLISPVIVCAKVIMQK-LWAD-K----------L------ -GWTD-P-LQG--ELLKEWLDFRSSLDGLK---D-IRIP--RCA--V------------- --VP-G-AV--RY-EVHG-YSDASTV-AYG-ACVYLK--CFMP-DS------KTVVSR-- LLCS---------------------------KSRV-APL-------K------------- ---Q----------------------------LTIPKLELEAAL-LLS-LLVVKVLAT-- -L-D----L-E-I---AEV---VL---------KS------------------------- ------------------------------DPPDTKKFYLPHHAV-------LKPS-SSS TKL-RVVFDASAKS--SR---YSLNDVLKVGPTVQ--SDLFSILLHFR---RYLI--AFS ADAVKMYRQVKIVPE--HRPFQR-----I------FWRKE---P-SD---------RL-R VLELNTVTYGTASAPFLATRC-LTQL------------A----ESA-KDRF--P-KTAKK I-KED--VYVDDM-LSGAD-T---AEEAQTCVKEVK-EL-LAEG-------GFQIK-KWC SNSE-AV-LEGVPEEDREILV------KID---------------------------ECS VSEGI-----------------KA--LG-------------------------------- -----ILW---------------------------------------------------- ----------------------------------------------------------NV AAPFEFTGVDYAGPML-------------------------------------------- ----------------------------VK--QGKYRP---KVV------KA-YIA---V -FVCMA--TKNVHLELVSELTAEAF-----IAALERF-INRR-GMVRKLFSDNGTNFVGA SGMLR-D-------FYRLLSSD-LL------------------LRELH---ELLLPKEIE ----WSFIPPRAPNFGGLWEAGVKSVKTHLKRTLV--N-----ATL----TFEEM----- --ATM-----LTHIEAILNSRP--------LYS------------A-------------- ----------------------SD--------CPG--D-------A-------------- ----------- >673/1-555 ---PTKREVLKVLMSIFDPLGLIAHLLIYLKVLLQE-IWRS-G----------V------ -QWDE-E-IND--TLFLKWQTWLRVLPEVE---N-VQVP--RCY--T------------- -LQDFPN-CK--V-ELHT-FVDASET-GFA-AVSYLR--FSN--SX------KVEC-I-- LITA---------------------------KTRV-APL--K-F---------------- --------------------------------QSIPRLELQAAV-LGA-RLAQTITES-- -L------S-IQA---XRR---XF---------WT------------------------- -----------------------------------RTWYLPVFPV-------FNPN-K-P GKV-RIVWDAAAT-I-FG---VSLNSALLKGPDQL--CSLFAILLQFR---EHKI--GLT GDIREMFHQIKIREQ--DRSCQR-----F------FWNNG---A-GE---------T--A VYEMCVMTFGACCSPSTAQYV-KNLN------------A----ERF-CGLY--P-KAVDA I-IKR--HYVDDM-LVSVE-T---EEEAIRTAQQVK-CI-HSQG-------GFEIR-NWI SNSP-AV-LQSL--GE---EDTK---TKNLDL-----------------------SAE-M ET--E-----------------KV--LG-------------------------------- -----LWW---------------------------------------------------- ----------------------------------------------------------AY SRPFTHVGIDYFGPME-------------------------------------------- ----------------------------IA--IG-R-----R-VE-----KR-WGM---L -ATCMT--TRAVHIEIAHTLSTDSC-----VMAIRNM-IARR-GIPRYIYCDRGTNFVGT SKELS-R-------VEEELNVE-I----------------------MM---KEFTSSETV ----WSFNPPLSPHMGGCWERLIRSVKNSLKSLKL------P-RRP----TDEVL----- --RNA-----LIEIENTLNSRP--------LTH------------V-------------- ----------------------SI-------------EDTAAPALTPNHI---------- ----------- >674/1-560 ----TKRTVLSQMSSLFDPLGLLGPSIVRAKILMQS-LWKQ-H----------L------ -DWDM-P-LPD--NFRKDWEDFHDSIPFIR---D-FKVS--RSV--V------------- --KYPY-HR--L--ELHG-FSDASEL-AYG-ACIYLR--SVDE-ND------KCSV-E-- LLIA---------------------------KSRV-API--N-N---------------- --------------------------------KSVPRLELSAAL-LLA-HLLEMVNRS-- -T-S----L---S---VPV---YL---------WT------------------------- ------------------------------ELCQRPQFFLPHHGV-------LKMD-SAT TKL-RTVFDGSCKSS-SG---LSLNDVLLAGPTIQ--DSLVEIVVRFR---IHRF--VIS ADIEKMFRQIFIHPE--DQPLSR-----I------WFRFD---S-DH---------PL-K AYQLTTVTYGLNSSPFLATRV-LKLL------------S----EDE-EANF--P-LAAPV A-RKD--FYMDNL-LSGCN-D---ESELVTVVQQLI-EL-LRAG-------GFPLR-QWS SNCQ-AV-LDSIPEELKETRT--L-L-ELD---------------------------D-- YNPTI-----------------SA--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TR SFPFDNVGVDFAGPLY-------------------------------------------- ----------------------------VRKA--HRKA---IPI------KV-YAA---I -YVCLG--VKAVHLDLVPDLTTEGF-----IASLRRF-VGRR-GKPHHIYCDNGRNFVGA QRELG-E-------LRRLFLSQ-AH------------------KDVVI---KECADGGTE ----FHFIAPRSPSLGGIWEAAVKSMKFHLRRVVG--N-----ALL----TETEL----- --RTV-----LIQIEATLNSRP--------ISP------------M-------------- ----------------------SE--------DPQ--D-------L-------------- ----------- >675/1-518 ---PTKREVLKVVMSLFDPLGFVSFFLVHGKVLMQD-IWAS-G----------I------ -NWDE-H-ISE--HXHVRWRQWITYFPRLD---T-LQIP--RCY--F------------- -SSPFPK-NFDRL-ELHV-FVDASDS-AYA-CVAYYR--LET--EN------GIQV-S-- LICS---------------------------KSKV-APL--K-V---------------- --------------------------------LSVPRLELKAAV-LGV-RIIESIEGY-- -H------T-YAI---SRR---FL---------WS------------------------- -------------------------------------WFLPLGVV-------VNPK-K-P GKI-RLIWDAAAK-V-DG---VSFNSYLLKGPDLL--TPLPRVLSGFR---LFPV--AVS GDIREMFLQIKLQKG--DRNTQM-----F------VFRHN---P-AE---------P-VQ IYAIEVTMFGSTCSPSSAQFV-KNAN------------A----EQY-ALHY--P-RAAAA I-KEH--HYVDDY-LDSFR-T---IEEAIQVVNEVK-LV-HSKG-------GFEIR-NFL SNEN-EV-LKQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFTFVGVDYFGPIL-------------------------------------------- ----------------------------VK--VG-R-----S-CV-----KR-WVA---L -FTCLT--VRAIHLEVVHSLSTESC-----IMAVRRF-IARC-GFPAEFYSDNGTCFQGA SKELK-R-E------MEN-RNN-S----------------------LA---TTFTTAKTR ----WCFNPPSAPHMGGVWERLVRSVKAAIGTIAD--A---S-RKP----DDEIF----- --ETI-----LLEAEALINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >676/1-565 ---PTKKIVLSEIGKLFDPLGFLGPVVTKAKLMMQK-LWEL-K----------L------ -GWDT-E-LPD--EQMQRWLVFREQLVLVR---N-IKKR--RCV--I------------- --PA-D-AK--KL-ELLG-YCDASKA-AYG-AVLYVK--SELK-HG------TINI-Q-- PVCS---------------------------KSRV-APL-------K------------- ---P----------------------------TTIPRLEACGMV-VLA-ELTHKTLGA-- -L-N----V-K-F---DRV---RL---------FS------------------------- -------------------------------------YFLPHHAV-------YKEA-SST TKV-RVVFDASAATT-TG---VSLNDTQLVGPTVQ--SDLVTIMLRFC---THQV--VLT ADVPKMYRQVQVHPD--DRKYQR-----I------LWLND---A-NE----------M-A TFELATVTYGCSSAPYLATKA-LTQL------------A----SDE-ADKF--P-KAVRV V-KED--SYIDDF-LTGGK-T---AADVVEIYEQLK-DM-LSRG-------GFGVH-KFC SNSA-EV-LKHIPAELQEKLV------DFE---------------------------TSE INDTI-----------------KT--LG-------------------------------- -----LIWNPNYDYFTFN-------------------------------V---------- ----------------------------------------------------------TP APVFASTGVDFAGPFT-------------------------------------------- ----------------------------LR--ESGRKP---KFY------KA-YVA---V -FVCMA--VKAVHLELCTDLRTETF-----LAALQRF-TSRR-GLPSNLHSDNATTFVGA KNELA-E-------LRELFENQ-VH------------------KDKLA---DFCSSKGIT ----WHFIPPRSPHFGGIWEAGVKAMKYLLKRVVG--E-----TRL----TYEEM----- --TTF-----LAQAEATMNSRP--------MCP------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >677/1-588 ---PTKQMVLSEMSKLFDPHGLLAPTILIAKLLMQQ-LWQA-N----------V------ -GWKD-P-IPQ--EQLRTWNRFRSELSCLN---S-LRIN--RRI--T------------- --VD-D-AV--DV-ELHG-YADASKV-AYG-CSIYLK--SFKR-DG------TTEM-Q-- LICG---------------------------KSRV-APM-------K------------- ---ELQRNEKQDATPDE---------------QTIPRLELCAAL-LLA-EILEKVRET-- -L-A----I-P-I---EKV---KL---------WS------------------------- ------------------------------EPTNADAYYLPHHCV-------IKPD-SST TKL-RVVFDASAKSS-TD---LSLNDVMEIGPTVQ--DSLFNILLRFR---LHKF--VFT ADVPKMYRQVIVDEA--HRKYQR-----I------LWRDN---A-GQ---------PI-K ELELNTVTYGTAAAPFLATRA-IVQL------------A----RDE-QKDF--P-VASKV V-EEC--FYVDDV-LTGAD-S---LPEAKELQRDLI-AL-LERG-------GFQLH-KWC ANDE-SL-LEDIPVDAQEQQF------NLD---------------------------DCN ASGVV-----------------KA--LG-------------------------------- -----ILWDPVGDEFMYHVQPF-------------------------------------- ----------------------------------------------------------TA SQPFARTGMDYAGPFY-------------------------------------------- ----------------------------VK--VGRMRS---K-V------KV-YVC---L -FVCMA--IKAVHLELVGSLTTEGF-----LAALQRF-VNRR-GTPSELYSDNGTNFRGG NRELS-E-------LVELLRSQ-IL------------------QKKVD---AFCQPRGIT ----WNFNPPKAPHQGGIWEANVKCMKSHLCKTLT--E-----SYL----TFEEL----- --NTL-----LIQVEGILNSRP--------LVQ------------L-------------- ----------------------TD--------DPF--D-------Y-------------- ----------- >678/1-573 ----TRRKVASQVAKIFDPLGFIGPVLTAAKLILRG-VGSL-K----------T------ -DWDE-L-VPP--NMGRQWQSFRRELPVLK---K-LRLP--RWI--L------------- --YKEMQFV-----ELHG-YCDASDQ-AYG-ACIYTR--LTRL-DG------STVM-K-- LVCS---------------------------KSRL-LPK--A--TKK------------- ---KKE--------------------------ISTPRGELLAAL-LLA-RLVTKVLSS-- -TS-------TTF---ASV---NL---------WS------------------------- ---------------------------------------LPHHCV-------IKPT-STT TKL-RVVFDGSARTT-SG---VSLNDALMTGPTVQ--NDLMAILLNFR---CYRF--ALT LDIPKMYRQVRINPD--DARFQR-----V------FWRDD---K-NQ---------PL-K IFDLLTVTYGLASSPFQATMT-LNQL------------A----DDH-GAEF--P-RAAAV L-QSS--CYIDDV-LTGAQ-S---LDDALQLQREIV-GL-LRCG-------GFAAH-KWC SNAP-SI-LEAIPEAQQGAKL------NVA---------------------------ELD LNALV-----------------KT--LG-------------------------------- -----VAWQPASDTF----------------------------SFDVVDF---------- ----------------------------------------------------------QP APTFARTGIDFAGPFW-------------------------------------------- ----------------------------IKSNAAVRKP---TIT------KG-YVC---L -FVCLC--TRAIHLELVSNLSSDAF-----LAALRRM-ASRR-GVPSTILSDNGTNLVGG NNELE-E-------LARLFQNE-LH------------------QKNLD---SFCSSKNIE ----WRFIPPRSPHFGGIWEAGVKSMKYHLKRIVG--E-----RRL----TFEEL----- --YTT-----LTQIEAVLNSRP--------LTQ------------S-------------- ----------------------SD--------DPN--D-------F-------------- ----------- >679/1-539 ---PTKREVLRTVMSLFDPLGLLAHYIIQGKILMQD-IWRS-G----------T------ -DWDE-P-ITE--NLRGQWYRWSQLLWKLN---T-VQVP--RCF--F------------- -SGVSKE-ALNRL-QIHV-FVDASDT-AYS-CVAYLR--IVE--SG------APRC-S-- LVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQAAM-IGS-RLINSLCTS-- -L------N-LQI---KQR---FL---------WV------------------------- ---------------T---------------TQRSKVWYLPLGFV-------QNPK-K-P EKV-RLIWDAAAR-V-EG---VSFNDMLLKGPDML--VSLFAVLLRFR---QKNV--AIC GDIREMFHQISIRSP--DNQAQR-----F------LYKPS---P-DR---------P-PQ IYVMDVATFGATCSPCQAQYV-KNQN------------A----NDL-ADRY--P-TAAEA I-IKA--HYVDDY-LDSTD-T---VDEAVQLLSDVK-YV-HSQG-------GFEIR-NFC SNST-EV-LRRM--GQ-TKSP----DYKSMNL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VKPFSHTGVDYFGPVL-------------------------------------------- ----------------------------VK--QG-R-----S-LV-----KR-WIV---L -FTCLT--IRAVHLEVAYSLSTQSC-----VMAIRRF-IARR-GSPETFYSDNGTNFIGA NRLLI-Q-Q------LRT-VHE-S----------------------CA---VTFTNAKTS ----WRFNPPLAPHMGGPWERMVRSVKSAMAEIAD--Y---H-KHP----SDEVL----- --ETV-----ILEAESVINSRP--------LTY------------V-------------- ----------------------PL-------------DS--------------------- ----------- >680/1-570 ----TKRVVASEAARLFDPYGLLQPVVIIAKIFMQR-LWEL-K----------L------ -NWND-V-LNE--EMQEEWRDFRRNLMGLD---G-ITVP--RWV--G------------- --IGDE-NE--AV-ELHG-FCDASMV-AYG-ACIYVR--TVAK-DG------SVSV-R-- LLIS---------------------------KSRV-APL--D-NQKR------------- ---KNKK-------------------------QSIPRLELTSAL-LLT-HLYHKVISA-- -C-P----S-LKS---AKA---YF---------WT------------------------- ------------------------------DEGEGVAYYLPHHAV-------LRPD-SST TKL-RVVFDASCRSS-TG---VSLNDVLLVGPVVQ--DDLIDITLRFR---LHRY--AIV ADIEKMYRMIKVQEP--DQRLQR-----I------FWRDS---T-DE---------FL-R IFELTTVTYGTASAPYLATKC-LQKL------------A----EVG-AETH--P-VAAQV V-KND--FYVDDM-TTGVQ-S---IEQGKQLVHEMV-QL-MESA-------GLSLR-KWN SNSR-EI-LMNVPESLRDCRA--L-L-DMD---------------------------T-- SSSTV-----------------KT--LG-------------------------------- -----TIW---------------------------------------------------- ----------------------------------------------------------LP STPFSKVGVDYCGPFH-------------------------------------------- ----------------------------IVYP--HRRA---QPI------KS-FVA---I -FVCLV--TKAVHLELVADLTTQAF-----LAALKRF-TARR-GKPSVIMCDNAKNFVGA QRELE-D-------LRRLFNNQ-VS------------------QEKII---NEAANEEIT ----FKFIPARSPNFGGLWESAVRSFKLLFKRTIG--T-----HNL----VYDQM----- --QTL-----LAQVEAVLNSRP--------LTP------------L-------------- ----------------------SS--------DPS--D-------Y-------------- ----------- >682/1-571 ----TKRVAASEMAKLFDPTGIVGPVVVKAKVFIQG-LWRK-G----------Y------ -SWDA-P-LPD--RRAAEWQTFRDDLAALK---T-ISVP--RLT--K------------- --APGAGDQ---X-ELQG-YCDASND-AYG-ACIYIK--SKGA-DG------KISV-N-- LLTS---------------------------KSRV-AHI--L------------------ -----P--------------------------MPIQRLELCSAL-LLA-HLYCQVVES-- -LG-------LQN---ITT---YL---------WT------------------------- ---------------------------------------LPHHAV-------VKPS-SST TKC-RVVFDGSSKSS-TG---ISLNDCLMVGPTVQ--DTLYSIVLRFR---MQEV--ALV ADITKMYRQIWVHPD--DRRLQR-----I------FWQQP---A-DP---------EV-R EYELTTVTYGTASAPYLATRC-LKQL------------S----YDHSESAN--D-AAAK- I-GRD--FYVDDL-LSGAP-T---IDEAVQVRGEVQ-NI-LGSA-------GFELR-KWA SNSA-EV-LRQIPPELQDERSLLE-IDSPS------------------------------ -DTTV-----------------KT--LG-------------------------------- -----LLWHPESDTFRFKVP----------EF---------------------------- ----------------------------------------------------------TP ARPFLNTGVDFCGPVW-------------------------------------------- ----------------------------IKQS--TRRGRAVPPV------RA-YIA---L -FVCMA--TKATHIELVCDLSTEGF-----IAALRRF-VARR-GRPLSLYCDNATNFTGA EKELK-L-------LLXQFLDQ-QF------------------REKVS---AYCAESTIQ ----FHFIPARAPTFGGLWEAAVRALKYHLRRVVG--T-----EAL----TTEAM----- --QTV-----LCQIESCLNSRP--------LTA------------V-------------- ----------------------SE--------SPN--D-------V-------------- ----------- >683/1-550 ---PTKSIVLKFLMSFFDPLGLIAHYLVHGKILMQD-IWRS-G----------C------ -DWKA-T-IND--DCYAGWTQWIKWLPHLE---Q-LQIP--RSY--F------------- -GDIRSS-KIESV-ELHV-FSDASEK-AYG-SGAYLR--IVC--DG------AIRC-T-- LALA---------------------------KTKV-APL--K-L---------------- --------------------------------LSIPRLEVSGAV-LGA-RLANTAETC-- -H------S-LPI---SRR---VF---------WV------------------------- ---------------D---------------SDPRKVWYIPLSVV-------VNPR-K-- AKV-RLVWDAAAS-V-NG---VSLNSQLLKGPDLL--VSLIEVLCRFR---ERPV--AFG GDLQEMYHQVRIRSE--DKQAQR-----F------LFRDN---P-TL---------K-PD VYVMDVATFGATSSPASAQFV-KNKN------------A----AEF-AHVH--P-EAAAA I-IQR--HYVDDY-FDSAD-T---EEEAIERAQAVK-HI-HAQG-------GFHIR-NWV SNST-RF-LEAL--GE-----PNQKQTVQFTS-----------------------D-KHT NT--E-----------------RI--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------PY LRPFSFVGVDYCGPIT-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WIA---V -FTCFN--TRAVHLEVAHSLNKQSC-----LMALRRF-MCKY-GVPREIFSDNGTNFHGA NNEGV-L--------IRA-INN-N----------------------CA---DVVTDARLK ----WNFNPPSAPHMGGVWERMVRSVKECLKV-LD--D---G-RKL----TDEVL----- --LTV-----LAEAAEIINSRP--------LTY------------Q-------------- ----------------------PQ-------------DA--------------------- ----------- >688/1-536 ----TKRNLLSEISKLFDPLGWLTPLSTKLKLLFQR-LWKK-D----------L------ -MWDD-L-VPE--DVHIEWSRLTTDIDNIN---N-CTIP--RWI--S------------- --SEEN-----NIIELHG-FCDASTA-AYA-CVVYAR--S-------------------- ----------------------------------------------K------------- ---NL---------------------------QNI-TIELCGAH-LLS-KLIKLIKAS-- -L------N-C-R---LEL---YC---------WC------------------------- ------------------------------------ECYMPHHGI-------LRKG-SSS SSL-RVVFSGSAST--SK---WSLNDIMHKEPNLQ--KNLQVLLLQWR---KIPY--AFT ADIEKMYRQILINSD--DQQLQK-----I------VWRQS---P-IQ---------PI-Q SFQLTTVTCGTKAASFLAMMT-LKQL------------A----LDE-RDKY--P-EAATV L-EGS--FYMDDL-LHGCY-S---TEKGKKLISDLK-EL-LKSS-------EFNLR-KWS SNKH-QL-LEQTQECNDKTIF----YFKAD------------------------------ -GGHF-----------------EN--IS-------------------------------- -----L------------------------------------------------------ ----------------------------------------------------------NQ AAPFYHTGVDYTGFVD-------------------------------------------- ----------------------------VKIN--KGRG---VKTT-----KG-YIV---V -YVCLV--TKAVYLDLVSDLTSSAF-----LASLRRM-AARR-GAPRHLYSDQGTNFVGA NRMLQ-E-------EYDTLCHV-LS-------------------DSLL---AEVAEMNIE ----WHFNAPSWPSAGGLWERAVQSLKWHLKRVVG--E-----QKL----TFEEY----- --CTI-----LAQLEACLNSRP--------LCS------------L-------------- ----------------------TE--------NIE--D-------LDYLSPAHF------ ----------- >69/1-553 -----RRGMLSTMNSLFDPLGFVAPVVLEARLIYRS-LCQQ-E----------I------ -EWGK-P-IPL--PELKRWEKWVASLARLH---D-ISIP--RSF--G------------- -LRGHED--IQRC-QLHY-FADASKI-DYG-VACYLR--VCNRYNN------EVRC-T-- FLMG---------------------------KSRL-APK--D-D---------------- --------------------------------VSISRLELVVVV-TAV-KMDQSLKME-- -L------G-LEL---CPS---MF---------WT------------------------- ---------------I---------------ITDRRIWYLPHHSV-------TNPH-K-P DKL-RVVFDCAAQ-H-QG---VSINQVLMQGPDLV--NSLVGVLTRFR---RDPI--ALV ADIEGMFHQVRVAQR--DRDCFR-----F------WWWPG---GNTS---------LQPT PHRMKVHLFGATSSPSCASFC-LRQA------------A----VDF-GGEF--EPSVSSV I-RNN--FYVDDC-LVSVP-T---PQIDVQMARDLR-SL-LAKA-------GFNLT-KWL SNSK-EV-IDSI-------PEQERSKSLQVRS-----------------------L--DG -QINE-----------------RV--LG-------------------------------- -----VNW---------------------------------------------------- ----------------------------------------------------------VN LPPFSHTGIDYFGPFI-------------------------------------------- ----------------------------VR--QG-R-----S-DI-----KR-YGC---L -FTCMT--TRAVHLELAKDLTTDAL-----INALRRF-IARR-GTPSHIYSDNGTNLVGA ERLLR-E-------SIQEWNQN-Q----------------------IH---EFLLQREIQ ----WNFNPPCASHMGGAWERMIRSVRRILLSISG--E---K--TL----NDDQL----- --TTL-----LLESEAILNCRP--------LTP------------V-------------- ----------------------T--------------------------L---------- ----------- >695/1-560 ---PTMREVLSFVMSVYDPLGLISHVTIAGRILMRE-LHVI-T----------K------ -DWDS-T-IPD--ELQEKWEECLRVVKSAE---K-IRIP--RQL--V------------- -ITL--N---DPL-ELHT-FVDASEN-AFA-ACVYARTVTKEG-TV-------FIN---- LVAG---------------------------KARV-API--N-P---------------- --------------------------------LSIPRLELQAAV-LGV-RLTESIRKE-- -L------R-LFV---KHI---TY---------WS------------------------- -------------------------------------FYLPHFVV-------VNRN-KPI PKP-RLVFDAAAE-V-NH---ISLNSQLLSGPDEM--ASLFGVLLRFR---EGNI--CVT GDIQEMFHRVRIREE--DQDSQR-----I------LWRDC---E-N----------RCPD VYVMQVMTFGATCSPACAQVV-KNTN------------A----AAH-AETH--P-LAVDP I-VRQ--HYVDDY-LDSFF-T---MEDAIETVRQVI-EV-HKAA-------DFHIR-NFT SNRG-EL-LKTI--------PQDRVQQKTTSV-----------------------QIEEK GQDYE-----------------KI--LG-------------------------------- -----VHWNPTIDYFGFQV----------------------------------------- ----------------------------------------------------------PY TPPFYNTGVDYFGPIE-------------------------------------------- ----------------------------VQ--VK-R-----S-LE-----KR-WGA---I -FSCMN--TRAVHIELAEKLDTDSF-----MVCLKNF-QNRR-GKICNMYSDNGKNFVGA ERELR-E-------LVTEIDKR-M----------------------GH---ESALKYEIK ----WHFNPPSAPHFGGVWERQIQNIKKGLRHMFS--EWS-H-RHP----TPETL----- --RAT-----LIEIEAMLNSRP--------LTH------------I-------------- ----------------------PL-------------EN--------------------- ----------- >696/1-552 -----KRHLVSRIAKLYDPIGMLQPVIIRAKIMMQN-LWRD-G----------I------ -EWDE-E-VSP--CVIKEWNEFTAQLPLLR---Q-LQIP--RMV--L------------- -PSETK-----NA-SIYG-FCDASAK-AYG-CAIYVR--YLNV-KG------KWKS-H-- LLCS---------------------------KSRV-APL-------K------------- ---E----------------------------LTLPRLELQAAL-LLA-EVYEKIKDV-- -F------D-TRI---TQT---KW---------WT------------------------- -----------------------------------VRYVIPHSCV-------IKPD-STT TKL-RVVFDASAKSS-SG---VSLNDIQAIGPVLQ--PDLMHIWLDFR---TQTV--VAT ADIAKMYRQIWVAEP--DTWMQC-----I------LWRND---P-QQ---------SA-Q MYRLRTVTYGEASSSYLACRA-LHEA------------G----QEV-RSTY--P-KIADV I-QKS--FYVDNL-SFGAA-T---PEELRDLRTGVE-RA-LLNR-------GMPLR-KWA SNVP-DV-IDDIPVEHRESTV------------------------------------QIG DKQAI-----------------KM--LG-------------------------------- -----LAW---------------------------------------------------- ----------------------------------------------------------TE SPAFTHTGVDLCGPFE-------------------------------------------- ----------------------------VIPG--SRSK---YKI------TI-YVC---I -FVCFS--TKAIHLEIVENQSTSAF-----ISALLRF-VSLR-GRPDIIYSDNGRNFVGA EKELS-E-------LRKTFNNR-EF------------------QDDVV---GAAAEKGIR ----FSFIPPRSPNFGGLWEANIKVAKRLLKAASK--G-----AQL----NVIEL----- --QTL-----LHQISAILNSRP--------LTA------------T-------------- ----------------------HTS--------PD--A-------I-------------- ----------- >697/1-541 ----TKREILRTLMSVYDPLGLLGHFLMYLKTLLQE-XWRG-G----------T------ -GWDQ-E-LSD--QTAGKWTEWLHVLPDVX---Q-VTIP--RCY--R------------- -CISST---DANV-ELHV-FCDASEK-GMA-AVAYFR--FEE--GR----DMHIEC-A-- LVGS---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRLELQAAV-IGA-RLAKTISQN-- -H------R-LSI---GRT---IF---------WT------------------------- -----------------------------------NDWYLPIFPV-------TNPN-K-P GKI-RMVFDAAAK-V-NG---VSLNSRLLSGPDML--AGLVSVLMKFR---ENRV--AIV GDIREMFHQVAIKEK--DQRSQM-----I------LWDGE---D-PD---------AGPA IYVVTVMTFGAACSPSSAQYV-KNVN------------A----GRF-ATEY--P-RAVEC I-VHE--HYVDDM-LASVE-T---EEEAKDLADAVR-YI-HACG-------GFEIR-NWV SNSR-AV-MQHL--Q----EDTK---GKNISA-----------------------NYG-L ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------VG QNAFSFTGIDYFGPFL-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---I -FTCLT--SRAVHLEIAASLNTASC-----ILAIRRF-IARR-GTPLEIISDRGTNFVGA SRELD-E-------AAQEIDHD-A----------------------MM---TVFCGPQTK ----WSFNPPGAPHFGGCWERLVRSVKKVLNQFVF------P-KRP----TDEIL----- --AST-----FAEIELILNSRP--------LTY--------------------------- ------------------------------------------------------------ ----------- >7/1-548 ----TKRQVLSHIAKLFDPAGWLAPFVIRAKIFMQQ-IWLT-E----------L------ -GWDD-V-LPP--LLLQQWHEFLQDYPGLS---R-LRIP--RWL--N------------- -TSDKL-----SW-ELHG-FCDASQK-AYG-AALYVR--VRYG-DQ------V-DV-H-- LLTA---------------------------KTRV-APV-------K------------- ---T----------------------------VSLPRLELCGAV-LLA-DLWASIVPE-- -L------P-IPP---ATS---QF---------WT------------------------- -------------------------------------FYLPHHAV-------FKPD-STT TKV-RVVFNASSPST-RG---VSLNDVLHTGPTLQ--ADLTLQVLKWR---FFQF--VFN ADITQMYRQIRVDPR--HTPFQR-----I------LYR-D---R-CG---------NI-Q DYELQTVTFGVNCAPFLAIRV-LLQL------------A----QDV-QAMY--P-QASEI L-RNY--MYVDDV-LAGAH-T---EADARLAIRELQ-AT-LQSA-------GLPLR-KWT SSKK-EV-LQAIPREHLLRED----FLELE------------------------------ DASTA-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------TY SRPFTHTGIDFAGPFE-------------------------------------------- ----------------------------IKNY--TGRA---CLIT-----KG-YVC---V -FVCFS--TKAIHLEATSDLTTERF-----LAAFSRF-VARR-QCPQRIYSDNGKTFVGA SKALEQD-------FLNAT------------------------KLDIM---KAFPQHILS ----WQFIPPSAPHMGGLWEAGVKSFKTLFYKSSS--T-----VKY----TFEEL----- --STL-----LCRIEACLNSRP--------ISP------------M-------------- ----------------------SE--------DPE--D-------L-------------- ----------- >70/1-565 ----TRRGILSVVSSIYDPLGFAAPVLIKGRLLWQR-LCKR-G----------L------ -NWDE-K-VSQ--EEENEWINWLEDLPGLE---Q-VRVQ--RCF--K------------- -PPSLGK--VIHT-ELHH-FADASTV-AYG-AVSYLR--FIDI-KG------NIHC-S-- FLIG---------------------------KARV-APM--S-T---------------- --------------------------------MSIPRLELTAAV-LAV-RHDQLARRE-- -L------N-LTS---CQS---TF---------WT------------------------- ---------------------------------SRKRWFIPHHPV-------VHPR-K-P GKV-RVVFDCAAK-H-NG---VSLNDVLMQGPDLT--NSLIGVLTRFR---QNQI--ALV ADVEGMFHQVRVDPR--DTDMLS-----F------LWWKG---GNLQ---------DNPT VYQMLVHLFGATSSPSCAAFC-LKEC------------A----RVY-GDDY--DDLAANV V-KNN--FYVDDC-LVSVE-N---IDKATKLVTDLR-EL-LARA-------GFHLT-KWL SNNA-EV-LKTI-------PEKERAKNASSLN-----------------------I--DA -CLDE-----------------RV--LG-------------------------------- -----VQWRVQSDEFSFTVTPQ-------------------------------------- ----------------------------------------------------------AG EPAFSHVGVDYFGPFS-------------------------------------------- ----------------------------VK--QN-R-----S-EI-----KR-YGC---I -FTCLT--IRAIHIEMANDLSADSF-----LNALRRF-IGRR-GKPKQIYSDNGTNFVGA EKILR-S-------SLALWNRE-Q----------------------IA---EHLRQRAIA ----WSFNPPAASHMGGVWERMIRSVRRLLSSMHS--P---KG-LL----TDEAL----- --NTL-----FVEVESIVNSRP--------LVP------------V-------------- ----------------------I--------------------------I---------- ----------- >703/1-519 ----TKRNLLSWITRVFDPLGLLSIFTIREKILLKE-ILVL-R----------V------ -DXDD-E-LPE--NVXKKIKCWLKEAEHIM---K-VEIP--RCL--I------------- -------EENKHGWEFHD-FLNASSK-AVG-AVVNIREQIKRRENL-----------R-- LVTS---------------------------KGKV-APL--K-T---------------- --------------------------------ISIPRLELLSVC-AGL-KLRKVATTI-- --------D-CDI---NSV---TF---------XT------------------------- -----------------------------------TKWFLPHFPV-------IKRD-RQS TKV-RIAFDAAVK-D-ED---YCLNDFIETSHNLQ--NDLMEILLMFR---RYKI--AIV CDISEMFLQVQVKEK--ERTYLG-----F------LW------S-EN---------GQVK SYEFTKXVFGLNASPSLVQIV-VQEN------------A----IKY-IKEF--P-HAVET I-TRS--TFMNDS-LDSVE-T---EEEAQNLKSNLE-MI-WHKT-------GMEVR-KWM TNSS-RL-LSMI---------PEECRAKTLNV-----------------------DN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------NYAGPFL-------------------------------------------- ----------------------------AVQRRG-I-----T-PA-----IG-YLC---L -FTCLQ--TRAVHLEMAYDLETEAF-----IRAFLRF-IIRX-GKPRTMISDNGTNFDGA ATRVK-D-------IVID--NY-K----------------------LE---KVLLENEIR ----WKYNPPMAPHFGGIFKAMIRAVKKAMSVIMS--N-----TDM----TDEEL----- --NTL-----IIRAKDMVNSRP--------MTL--------------------------- ----------------------MV--------DYSKE-L--------------------- ----------- >705/1-533 ----TKRSILRFVMSVFDPLGLISNLLAHGKVIIQD-LWRA-Q----------V------ -GWDD-T-IPL--DILENWNRWIEQLTKLD---R-LRIP--RCY--F------------- -SGYNPD-SYQTL-QLHI-FVDASES-AFA-CVAYFR--IID--YG------QPRC-A-- LVAS---------------------------KAKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-IGS-RLAKSVAEY-- -H------K-FPV---SRR---VF---------WS------------------------- ---------------------------------------LPHHCV-------LKPT-SST TKL-RVVFDGSAESS-SG---VSVNQAMMVGPTVQ--TDLISILLQFR---SHRY--AIS ADIPKMYRQVNVHDD--DTSFQK-----I------LWRDT---E-DQ---------PL-K TFALQTVTYGLASSPFLATMA-LRQL------------A----EDD-GHNY--P-LAAEA V-KKT--FYIDDM-LTGAE-T---KEGAAELLRQVL-GL-LSGG-------GFSAH-KIC SNSN-EI-MNMVPEH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AS VYPFATVGVDFAGPFT-------------------------------------------- ----------------------------VKSSVSIKKP---SMT------KG-YVC---V -FICMA--TRSLHLEAVSNLSTDAF-----LGALQRF-VSRR-GIPDKIISDNATNFIGA SGELE-R-------LATLFKSE-MH------------------QKKLN---EFCTQRNID ----WSFIPPRSPHFGGLWEAGVKSVKHHLRPILA--G-----HKL----SFEEL----- --CTV-----LCQIEATLNSRP--------LTS------------S-------------- ----------------------SD--------DPN--D-------M-------------- ----------- >706/1-543 ---PTKRQVLRCVMTLFDPLGLLSPFLIHGKVLIQD-LWRE-G----------T------ -EWDE-Q-VNT--EVFAKWQRWTQMIEYIA---E-IRIP--RCY--F------------- -RHAEQT-TYRNS-ELHV-FVDASEV-AYS-CAVYLR--TLNH-GA------DPQC-C-- LIAA---------------------------KSKV-APL--K-P---------------- --------------------------------WSIPRLELKGCV-LGV-RWSKFVSEN-- -H------G-VHV---SKM---VF---------WT------------------------- -------------------------------------WYLPVGAV-------MNPK-K-P GKV-RVIWDAAAK-V-EG---VSLNTTLLKGPDQL--SSLPAILFRFR---LYRV--AVS SDIQEMFHQIRIREE--DKNSQR-----F------LWREK---P-SE---------K-PS VYLMDVATFGSTCSPASAQFV-KNLN------------A----EQH-RELY--P-EAAKA I-VDD--HYVDDY-LTSFS-T---EDEAARIASDVR-TI-HGNG-------GFKLH-NWR SNSS-AV-LERL--GEV----QAEA-EKQLAL-----------------------V-DGA KT--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------HH ERAFTYTGMDYFGPLL-------------------------------------------- ----------------------------VK--LG-R-----S-NV-----KR-WIA---L -FTCLT--VRAVHLEIAYTLSTESC-----ISCVRRF-VGRR-GPPAEFFSDNGTNFQGA DRVLR-H-Q----------IGQ-G----------------------LS---ETFTGANTK ----WNFIPPGAPHMGGAWERLVQSVKAAMMEA-Y--S---E-GKL----DDEGL----- --QTL-----VVETESIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >71/1-551 -----KRTVLSTLAKIYDPLGWLAPVTIIGKLFMQK-LWLT-D----------K------ -KWDE-E-LSK--EEIKEWKEYQDNLKHLQ---N-LRIP--RWV--K------------- --IQKD-----IEVQFHG-FADASEK-AYA-AVVYAK--V------------GNSV-M-- ILAS---------------------------KCKV-NPK-------K------------- ---NR---------------------------KTIPKLELCAAH-LLT-KLISKITES-- -I------K-I-N---VEI---FA---------WS------------------------- ------------------------------------KYYLPHQAV-------LRDS-SLT TKL-RVVFDASAKTT-NK---KSLNDIMWTGPRVQ--KDIFDIILKWR---RWEY--VVS ADIEKMYRQIKIAKH--DQEFQY-----I------VWRDS---P-SK---------KL-K NFKLTTVTYGTASAPYLATRV-LLDI------------A----NN--CN-N--A-TIKEI I-KTD--FYMDDL-MTGAE-S---IQNCKEIVECVS-SE-LAKV-------GFNLR-KWI SNKS-EI-IEEIDRNEENKVL------------------------------------SIE ENESI-----------------KT--LG-------------------------------- -----LQW---------------------------------------------------- ----------------------------------------------------------TM SYPFLNTGIDYAGPYY-------------------------------------------- ----------------------------MKCS--KYRG---QKMY-----KG-YIA---L -FVCMA--TKAIHLEAVSDLTSDAF-----LAAMRRF-IARR-GKCLNIYSDNGTNFVGA AKKLE-K-------EFKKTIQE-NT--------------------KIS---STLEKEQIK ----WHFIPAASPHFGGIWEAGVKSVKYHLKRVIG--D-----SNL----TFEEM----- --TTL-----LCQIEAVLNSRP--------LYT------------T-------------- ----------------------GD--------DID--N-------IEVLTPGHF------ ----------- >710/1-573 ---PTKREAVSLVMSVYDPAGLISHITIQGRIQLRG-IHIA-V----------K------ -DWDQ-Q-IPS--NLADAWRSWLKQXNNIG---D-FVVP--RCI--R------------- -PAA--A---LFT-EIHT-FVDASKD-AFA-ACVYAR--SYDG-NI-------FTN-H-- LLAA---------------------------KARV-API--K-Q---------------- --------------------------------LSIPRLELQAAL-LGT-RLAKTVIAE-- -L------R-IEV---NRS---VF---------WN------------------------- -----------------------------------RVYYLPHFIV-------TNSN-KQE PKP-RIVFDAASK-V-QG---ISLNSQLLAGPDAT--TSLFGVLLRFR---EGNT--AVA GDIKEMFHQVKVRSE--DXYAQS-----I------LWREC---N-EQ---------KTPE IFVMQVMTFGATCSPACAQAV-KNEN------------A----SRH-KASH--P-LAYDA I-VSQ--HYVDDY-IDSFT-S---DAIAQETTNQVI-NV-HEHA-------GFYIR-NFI SNSD-TL-LQSI--------PADRRQVGETIV-----------------------AFEEK NGPYE-----------------KI--LG-------------------------------- -----VYWNTKSDVFGYNL----------------------------------------- ----------------------------------------------------------PY NPPFLHTGVDYFGPLE-------------------------------------------- ----------------------------VA--VK-R-----S-TE-----KR-WGV---L -FMCMS--TRAVHLELAKKLDTDSF-----LVCLKNF-QHRR-EKVSHLYSDNGTNFVGA ERELR-Q-------LVMDIDAW-M----------------------GK---EAALQFKIE ----WHFNPPSAPHFGGIWERQIQTIKKGLRQMME--EYR-L-RKP----SPETL----- --MAT-----LLQIEFILNSRP--------LTH------------I-------------- ----------------------PT-------------TRDEEEILTPFHF---------- ----------- >712/1-545 ---QTKRNILRCVMSLFDSQGILSHITIQGRMIIQD-TWRN-Q----------T------ -NWDD-E-VTE--PIRLRWFRWIKLFEEVG---Q-MRLH--RSY--F------------- -PGFTAA-EVGSV-ELHV-FTDASEE-AFA-CAAYFR--ATI--MG------RVHV-T-- LVMA---------------------------KAKV-APL--K-S---------------- --------------------------------LSVPRLELMGAL-LGA-RLAKAVKEY-- -H------T-LSI---ARR---VL---------WT------------------------- -------------------------------------WYLPLGAI-------RNPK-K-P GKI-RLVWDAAAK-V-GG---VSFNSKLLKGPDLL--TPLASVLCKFR---ERPV--AVC GDLKQMFHQFRIRQE--DAHSQR-----F------LYREH---P-SK---------P-VR AFVMDVGTFGATCSPCQAQYI-KNRN------------A----EEN-EEEF--P-EAAEA I-KEK--HYVDDY-LDSFD-T---EEEAIKVALEVT-EV-HARG-------GFCIR-NWH SNSD-AL-LKRV--GE-PRSG----QPKAISI-----------------------D-SES GA--E-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------AM VRPFSYVGLDYFGPVL-------------------------------------------- ----------------------------VR--IG-R-----S-CV-----KR-WVA---L -FTCLT--VRAVHLEVAHSLSTESC-----KMAVRRF-VARR-GSPIEIHSDNGTNFQGA SRELR-E-Q------LSA-IEQ-K----------------------LA---ESFTNTNTK ----WVFNPPSAPHFGGSWERLVRSVKVALGS-LC--S---D-RHP----DDETL----- --LTV-----ISEAEAIVNSRP--------LTS------------I-------------- ----------------------PL-------------EN--------------------- ----------- >716/1-557 ---PTKRVVLRTLMSIYDPMGLVGQFLMFLKMLLQE-IWRS-G----------Y------ -DWDR-E-IDG--HIAEKWFTWLKVLAKIP---Q-VTIP--RCY--R------------- -RVTST---SAKI-ELHI-FCDASEH-GMA-AVAYFR--FEE--GG------VIEC-A-- LVAS---------------------------KTRV-APL--N-F---------------- --------------------------------LSIPRLELQAAV-LGA-RLSKAIIRS-- -H------R-LEI---HRT---TY---------WT------------------------- -----------------------------------RDWYLPVFPV-------TNPN-K-P GKI-RLVFDAAAT-V-NG---ISLNNNLLTGPDLT--ANLLEVLFKFR---EFSV--AVV GDIREMFHQVLIKPA--DQRSQM-----I------FWEGD---A-AS---------DEPV TYAVAVMTFGAACSPSTAQYV-KNHN------------A----ERF-ESEY--P-RAVEC I-RNE--HYVDDM-LFSVE-T---EQEAISLAEQVR-YI-HSRG-------GFEIR-NWI SNSS-RV-MERV--QT---ITET---EKSFNM-----------------------GNE-F SA--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------LG QRPFTYTGVDYFGPLL-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---I -FTCLT--VRAVHLEVAHTLSTGPC-----IAAVRRF-IARR-GVPREIISDCGTNFVGT ARELR-D-------AIAGVDHE-A----------------------LM---TEFCSPELK ----WTFNPPGAPHFGGCWERLVRSVKKVLGHLNL------P-RRP----TDEVL----- --ETA-----LAEIELILNSRP--------LTY------------V-------------- ----------------------PV-------------DDATQQPLTPNQI---------- ----------- >717/1-551 ---PTKRQVLRTVMSLFDPLGLITHFVVQGKILMQD-IWRS-G----------T------ -DWDE-P-IAA--NLQDLWNKWSRSLAYLN---S-VQVP--RCF--F------------- -SNASRN-ALENT-QIHV-FVDASAE-AYA-CVAYLR--IID--RG------LPRC-A-- LVAG---------------------------KSKV-APL--K-P---------------- --------------------------------LSIPRLELQAAL-IGS-RLMDNICKS-- -L------N-IPL---HKR---FL---------WL------------------------- ---------------S---------------VDPRRIWYLPLGVV-------QNPK-K-P NKI-RLVWDAAAR-A-CG---VSFNDMLLKGPDLL--TSLTAILLRFR---QRNI--AIC GDIREMFHQIFIRQA--DKQAQR-----F------LWRTS---P-DT---------S-PK VYVMDVATFGATCSPSSAQFV-KNKN------------A----REF-EVQY--P---VDA I-INS--HYVDDY-LDSVD-T---VDEAVNRWNEVK-FV-HSQA-------GFEIR-NFI SNSP-DV-LLRV--EE-NSDT----KTKSMNL-----------------------D-QTE QK--E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------SF IRPFTNTGIDYFGPLM-------------------------------------------- ----------------------------VK--QG-R-----S-IV-----KR-WVV---L -FTCLS--IRAIHLEVAHGLTTQSC-----LMAIRRF-VARR-GAPETIYSDNGTNFVGA NNLLK-E-Q------LQK-INE-Q----------------------CS---ATFTNARTN ----WVFNPPAAPHMGGAWERLIRSVKTAMSAISD--H---P-HHP----SDEVL----- --ETV-----TLEAEAIVNSRP--------LTH------------V-------------- ----------------------PL-------------DS--------------------- ----------- >72/1-548 ---PTKKQIVAFSARNYDPSGLISPIIVPVKQLISS-MW-SRN----------I------ -GWKD-K-IPE--DLLPAWNAIKDQFNETT-----YTIP--RQL---------------- ---T-TNYEFSSA-QLVI-FSDASKA-HYA-TAAYIR--YGY-KDG------TFSS-G-- LVFS---------------------------KSRI-RPSNGGPE---------------- --------------------------------YTIPRMELMALE-IGS-NAAVNLAKE-- -L------H---MDL-KDV---VL---------FS------------------------- ------------------------------SKSDGPEYFIPHRVV-------VKE-DSLT TKL-RIVLDASSHMK-NE---LSLNDCLHPGPSIL--QSILGIMIRSR---LSKF--LLM SDIKRAFHQVRIQEQ--FRDVTK-----F------LWLED---P-SK----GYTEENL-R AFRFTRLPFGVSSSPFLLAVT-ILRY------------L-------EINEN--S-LN-ER I-KEN--LYVDNV-ILTSN-D---EEDLKEAYKQSK-AI-FNLM-------HMNLR-EYL SNSP-SV-MSAVAECDR--H---------------------------------------- PDQTC-----------------KL--LG-------------------------------- -----HQW---------------------------------------------------- ----------------------------------------------------------TF VGPFKFIGLDYIGPLQ-------------------------------------------- ----------------------------YK-RSD-GQG------------KL-WIL---L -VSCIF--TRAVHLEVVPDNTTVSF-----INGLRRF-ISRR-GVPQSILSDNAPLFKLA YSIIN-E-------DLKT----------VVNK-----------NEELT---SYLASKQIK ----IKLITPLSPWQGGAYERLVGLVKNTIQKVLS--K-----EVR----SFLEM----- --ETL-----VIETEGIINSRP--------VTP------------N-------------- ----------------------K--------------------------R---------- ----------- >720/1-522 ---PSKRKILQFIMSLYDPIGLISHVLIHGKIIIQD-LWRC-G----------V------ -GWDD-P-IPE--EVSETWRKFLTIFSELN---Q-VCVP--RCY--F------------- -PDYEKN-IYETL-ELHM-FVDASLS-AMA-CVAFFR--VID--CG------QARC-S-- LVAS---------------------------KAKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-MGS-RLMKSIVDS-- -H------S-VKI---KKR---FI---------WT------------------------- ---------------K---------------FNSKRTWFLPLGVV-------LNPR-K-P GKV-RMIWDAAAK-V-NG---ISFNGMMLKGPDLL--TPLPKVLFQFR---QRQI--AVV GDIREMYHQFFIREE--DRSAQC-----F------LWSAN---P-SQ---------P-PE IFIMDAATFGSTCSPCQAQFI-KNMN------------A----KNW-ASEF--P-EAALA M-VEN--HYVDDY-LDSRD-T---VEEMVKLATDVR-TV-HAKV-------GFEIR-NWL SNSG-QV-L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFSKIGIDYFGPYQ-------------------------------------------- ----------------------------IK--IG-R-----S-LV-----KR-WVV---L -YTCLV--IRAVHLEIAASLSTESC-----MLALRRF-IARR-GAPEQIFTDNGTNFVGT ERELA-K-Q------LQN-VNE-K----------------------LA---ESFTNESTK ----WNFIPPASPHMGGAWERMVRAVKAAMNS-IN--H---P-RSP----TEEVF----- --QTV-----LCEAESMVNSRP--------LTY------------I-------------- ----------------------PL-------------EN--------------------- ----------- >722/1-536 ---PTKRVVLSCVLSLFDPLGLLTPFTIYGRIFIQS-LWRT-G----------C------ -EWDE-M-IDD--ESARKWALWISRLSVVE---S-VKVP--RYY--F------------- -GDGLLL-NYSSL-QLHV-FTDASEC-AYG-CVAYFR--ILAG-GV-------PRC-S-- LVQA---------------------------KSKV-APL--K-P---------------- --------------------------------CTIPRLELMAAV-LGA-RMVDTVKES-- -H------N-LDI---GKV---FL---------WT------------------------- -------------------------------------WYLPLNVV-------LNPK-K-P GKV-RLVWDAAAA-V-QG---ISLNSQLLKGPDFL--TSLPSVICQFR---EHRI--GFG GDIREMFHQVKIRPE--DRQAQR-----F------LFSG--------------------Q VFVMDCAIFGATCSPSQAMYV-KDCN------------A----KQW-ESMY--P-EASMA V-VKK--HYVDDY-FDSAH-N---IEEAVQRASEVR-FI-HSQA-------GFEIR-NWV SNSE-EF-LQQL--GE-----TERSEAVHFNR-----------------------D-KST ET--E-----------------RV--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------PN LRPFSFTGVDYFGPLI-------------------------------------------- ----------------------------VT--VG-R-----R-AE-----KR-WVS---L -FTCLT--TRAIHLEVVHSLSSQSC-----VMAIRRF-ACRR-GMPIEFFSDNGTNFVGA CKEI-----------IGK-INE-D----------------------CS---DTFTDARTK ----WNFNPPSAPHMGGAWERLVRSVKEAMRV-FD--D---G-RKL----TDEIL----- --LTT-----LADAEEMINTRP--------LTY------------I-------------- ----------------------PQ-------------ES--------------------- ----------- >724/1-567 ---PTKREVLSQVARIFDPLGLLAYLTIGGKLLMQE-IWKE-G----------T------ -LWDE-R-IPQ--RLVPQWQAWTDNLKSAS---T-LKLA--RCY--S------------- -PFIPST---SSI-ELHV-FVDDSED-AFA-AAAYIR--VKTS-EG-------YDI-S-- LIAA---------------------------KTRV-APT--R-G---------------- --------------------------------MTVPRLELQAAV-LGT-RLANTIKEE-- -T------R-IKF---ASQ---VM---------WS------------------------- -----------------------------------KTFYLPQLAV-------ENPN-K-- -SP-RLVFDAKAK-V-QE---VSLNSELLTGPDEL--TSLFGVLIRFR---EGII--AVA GDIREMFSQVKMPQD--DQQALR-----F------LWRHG---D-ST---------QTMG HYVMQVMIFGATSSPACAQYV-KNRN------------A----ELY-IEKY--P-RAVDA --TKR--MYVDDM-LDSYN-S---TEEAIEVVTQIV-EI-NDNA-------HFELR-NFI SNDR-SL-LEAL--------PESRVSPTCAIK-----------------------EFNEK NGISE-----------------RV--LG-------------------------------- -----VYWDIESDTIKYKIDGIMEHVPTKREVLSQVA----------------------- ----------------------------------------------------------PT GKAFSHTGIDYFGPLE-------------------------------------------- ----------------------------IT--VR-R-----V-TE-----KR-WGT---L -FTCMA--TRAVHLELAEDLSSDAL-----IRCILSL-QYRR-GRIYALYSDNGTNMKGA SNIFK-Q-------LEQRI-----------------------------------AHKGIE ----WHFIPPSAPHFGGVWERMVQEVKKLLKVKLW--G---T-SRP----TENEL----- --KLA-----LAEIEYILNSRP--------LTY------------I-------------- ----------------------PL-------------EV--------------------- ----------- >725/1-562 ----TKRLVLSLIARLYDPLGLVGPVVTTAKVFMQD-LWTL-K----------D-DTGEP WSWDR-V-LPI--NYQTRWTNYQTLLPNLN---N-LRIS--RCI--L------------- --LP-E-PE--TI-QIHI-FADASQL-AYG-ACAYIR--STNT-AG------LVKV-S-- LLSS---------------------------KSRV-APL-------K------------- ---R----------------------------LSIPRLELCGAL-LAA-ELYEKIKLS-- -L-Q----L-N-----AKC---YF---------WL------------------------- ------------------------------EESTVKRFYLPHHAV-------LRED-SPT TKL-RVVFDASCKTS-AG---PSLNDALMVGPTVQ--EDIRSIIMRAR---KHQV--MIV ADVKMMYRQVLVDPR--DTSVQL-----I------VWKSS---P-DQ---------PM-E TYELKTVTYGTASAPFLATRV-LIQL------------A----DDE-GRNY--P-LAAPV I-KKD--FYVDDL-FSGGE-N---TAEVIELRNQLE-AL-LAKG-------GFELR-KWA SNNE-AV-LDGIPTENRAIKE--S-V-ELN---------------------------R-- -DQII-----------------KT--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------IA SRPFSITGVDYWGPIH-------------------------------------------- ----------------------------LKPI--HRRA---APG------KA-YVA---V -FICFS--TKAVHLELVSDLSTAKF-----IQSLRRF-VARR-GLCTELHSDNGRNFVGA ANELK-Q-------L---VNSK-DY------------------QNAVA---QECNKNQIR ----WHFNPPKASNFGGLWEAAIHSAQKHFVRVLG--K-----NTL----SHDDM----- --ETL-----LCQIESCLNSRP--------LVA------------L-------------- ----------------------SD--------DPS--D-------F-------------- ----------- >727/1-550 ---PTKRNILRWVMSVFDSQGILSHITVQGRMIIQD-TWRS-Q----------V------ -TWDE-E-VND--ATQTQWRKWIKLLEEVN---K-IRLP--RAY--F------------- -PGLSAV-DIGMV-DLHI-FTDASEE-AYA-ATAYFR--TVV--NG------KVYC-A-- LVMA---------------------------KAKV-APL--K-A---------------- --------------------------------VSVPRLELMGAI-LGA-RLAKAVCEY-- -H------T-IPI---RRR---VL---------WT------------------------- -------------------------------------WYLPLGVV-------RNPK-K-P NKI-RLVWDAAAK-V-GG---VSLNDMLLKGPDLL--VSLAAVLCGFR---QYRV--AVC GDLKQMFHQFRIRQE--DVHSQR-----F------LYREH---P-SK---------P-IK IFVMDVGSFGATCSPSQAQYI-KNLN------------A----EEH-ESEF--P-QAAVA I-KKK--HYMDDY-LDSFD-T---EDEAIKVALEVK-TV-HDRG-------GFEMR-NWH SNST-TL-LERV--GE-PKQQ----QMKAISI-----------------------D-TES EA--E-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------AT VRPFSYVGLDYFGPIQ-------------------------------------------- ----------------------------VK--VG-R-----S-CV-----KR-WVA---L -FTCLT--IRAIHLEIAHSLSTESC-----KMAVRRF-VARR-GSPLEIYSDNGTNFQGA GRELR-E-Q------IEA-IGK-G----------------------LE---ETFTNTSTK ----WIFNPPSAPHFGGMWERLVRSVKMALGS-LC--T---D-RNP----DEETL----- --ATV-----IAEAESVVNSRP--------LTF------------I-------------- ----------------------PL--------DDFAQEA--------------------- ----------- >728/1-554 ---PTKREMLKLVMSLFDPLGFVTFYLIHGRTLIQD-VWAS-G----------V------ -NWDE-P-VND--ELCQRWRQWISFLPLLN---D-LKIP--RCY--F------------- -RGQMD----ELK-QLHV-FVDASDT-AYA-CVAYLR--SSG--TQ------GIEL-A-- LVGA---------------------------KSKV-APL--K-V---------------- --------------------------------LSVPRLELMSAV-LGA-RLAESVVTA-- -H------S-FNV---AET---FL---------WT------------------------- -------------------------------------WYLPLSVV-------VNPK-K-P HKV-RIVWDAAAE-V-NK---VSFNSALLKGPDLL--SNLVFVLYHFR---EHRI--AVT GDIEEMFLRLLIRPQ--DSQSQR-----F------LWREN---S-RD---------A-PS VYVIDVATFGSTCSPSSAQFV-KNTN------------A----KEH-METF--P-RAATA I-IKH--HYVDDY-LDSFE-T---EEEAIEVVNQVK-FI-HSTG-------GFNLR-NFL SNSD-AV-LLAI--DGV----SQED-AKQLSL-----------------------S-RAE KV--E-----------------SV--LG-------------------------------- -----MKWNPSRDVFVYTL----------------------------------------- ----------------------------------------------------------PF VRPFTFVGLDYFGPLT-------------------------------------------- ----------------------------VK--VG-R-----S-EV-----KR-WVA---L -FTCLT--VRAIHLEVVHSLSSESC-----ILAIRRF-IARR-GTPAEFFSDNGTSFVGA NTQLR-R-E------IAT-RNG-V----------------------LA---STFTNTNTR ----WNFNPPGAPHMGGVWERLVRSVKDAVGTLID--T---P-RRP----TDEVL----- --ETV-----LLDAESMINSRP--------LTY------------I-------------- ----------------------PL-------------ET--------------------- ----------- >73/1-536 ----TKRKILSAINSVFDVLGFSAPVLITGKILYSR-LCLL-K----------I------ -GWDH-Q-IPK--ELLEEWQTWIKAISNKR---T-ILIP--RCV--V------------- ----SGR--IIEL-ELHG-FSDASKL-AVC-ACIYVV--TSHQ-NS------KT-S-N-- LLVA---------------------------KATI-ATK--D------------------ ---------------------------------SIPRLELVAAH-TLSCTLMNHVRKT-- -L--------YNI---SKV---FN---------WV------------------------- -------------------------------------HYIPHQAV-------IKE-NAKS TKM-RVVYDCSARKD-AQ--SPSLNDCLEVGPSLQ--PLIFDILIRNR---MNKL--CVL ADIKKAFLQIRIQDM--DRDAQR-----L------IWYED---L---KK------MKL-M ELRFTRVIFGSSSSLYILGAT-IKKH------------I----SKYKDIYP--K-TV-VA L-EED--TYVDDL-QAGGE-T---EEELIRFKYEST-QI-LNEA-------GFQLH-KWH SNVR-EL-ENN---------V--------------------------------------- E-------DKST----------KI--LG-------------------------------- -----HPW---------------------------------------------------- ----------------------------------------------------------DN VEPFAVSGVDFAGPLK-------------------------------------------- ----------------------------YKV--P--KN---SIK------KC-YVA---L -FTCAS--TRAVYLKLCHDLSAVEF-----QRVLKEF-VARK-GPPQMIISDNAKTFVAT GKWLL-T-------LKND--------------------------ENIA---NYLAIQAIK ----WRFNLSRAPWWGGLFERLIGIMKKSLSKTIG--K-----GML----TFNEL----- --EEV-----LLDVECSMNNRP--------LCY------------Q-------------- ----------------------GD--------QFD--N-------QV-LTPNVL------ ----------- >734/1-527 ---PTKREVLKILMSIYDPLGLLANVLMYLKVLLQD-IWRS-N----------I------ -GWDE-P-IAD--EQLEKWRTWLTVLHQVE---N-VAIP--RCY--R------------- -ANTTCSIDTNEV-QLHI-FVDASEN-GYA-AIAYLR--FEE--ST------NVEC-A-- FVTA---------------------------KTRV-APL--K-Y---------------- --------------------------------MSIPRLELQAAV-IGT-RLAKTLEET-- -H------R-MPV---KKR---FF---------WT------------------------- -----------------------------------RRWYLPIFPV-------VNPN-K-P DKL-RIVWDAAAK-V-GN---LSLNSFLLKGPDQV--TPLQYVLLRFR---EYRT--AVS GDIREMFHQVRINPN--DQHCQR-----F------LWNDG---D-PG---------KAPS TYVMEVMTFGASCSPSSAQYI-KNTN------------A----ERF-RSQL--P-KAVEA I-CDD--TYVDDI-LYSVE-S---EAEAIKIAHDVR-RI-HAEG-------GFEIR-GWL SNSK-KV-VDSM--GE---QN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY SRPFSYTGIDFFGPMQ-------------------------------------------- ----------------------------VV--VG-R-----R-TE-----KR-WGV---L -LTCLV--IRAIHIEIAHSLNTSSC-----IMAVRNF-MARR-GTPIELFSDRGTNFMGA NRELI-E-------ALQKLDQN-R----------------------LM---QEFVTPNTK ----WTFLPPSSPHMGGSWERLVQSVKKILNNMHL------P-RLP----TDEVL----- --RNS-----LLEVENIINSRP--------LTY------------V-------------- ----------------------PI-------------ED--------------------- ----------- >74/1-570 ---FTKRIILSDFAKLFDPLGLVGPSLVPAKVFLQE-LWRS-K----------C------ -SWND-V-LPD--ELQKWWREFRESLEGLT---H-LQVP--RWI--A------------- --FGSD-TI--SV-ELHM-FCDASTK-AYG-ACIYLR--CTSF-DG------TVTS-T-- LLTA---------------------------KSRV-APL--E-DLKK------------- ---KRKQ-------------------------ASIPRLELSSAL-TGV-YLFEKVVQS-- -I-K----I---T---AQP---YF---------WT------------------------- -------------------------------------YFLPHHAV-------LKPD-STT TKL-RVVFDASCAST-TG---VSLNDALMVGPVVQ--EDLTSITLRFR---LRKY--AMT ADIEKMYRMIKMHPM--DHPLQC-----I------LWRED---S-TK---------PL-R FFVLTTVTYGTSSAPYLATRC-LKKL------------A----EDE-KANF--P-AATNT I-IYD--FYVDDM-LKSVD-S---IEEAAQLSKDLV-HV-LGTA-------GLTLR-KWS SNSR-EL-LDQIPPYLRDERS--S-L-DLE---------------------------L-- SNPTV-----------------KT--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------NP APAFLRVGVDYCGPFY-------------------------------------------- ----------------------------IQYP--YRKG---GPI------KC-FVA---V -FVCLV--VKAVHLEVVGDLTTQAF-----IAALRRF-VSRR-GRPEIIMCDNATNFVGA RRELD-E-------LRKLFNRQ-EF------------------VKAVT---EEASWENIN ----FKFIPAKSPNFGGLWEAAVKSMKEHLKRTLG--N-----TVL----VSDEM----- --ATL-----VAQIEASLNSRP--------ITP------------L-------------- ----------------------SNDADDLEILTPG--H-------F-------------- ----------- >740/1-561 ----THRIVLSEIARLFDPYGLVGPVVVQGKLFLQE-LWRA-K----------Y------ -SWDE-P-LND--ELQSQWLDFRANLFKXD---T-VSVP--RWI--S------------- --FGKE-VV--SC-EFHG-FSDASDK-AYG-AAVYFR--YVDQ-VG------QVSV-N-- LIMA---------------------------KSKV-APL--E-DLSK------------- ---RKKR-------------------------QSIPRLELSAAL-LLA-HLYESVSSS-- -M-M----I---A---AKS---FF---------WT------------------------- -----------------------------------RDWYLPVFPV-------TNPN-K-P GKI-RLVFDAAAT-V-NG---ISLNNNLLTGPDLT--ANLLEVLFKFR---EFSV--AVV GDIREMFHQVLIKPA--DQRSQM-----I------FWEGD---A-AS---------DEPV TYAVAVMTFGAACSPSTAQYV-KNHN------------A----ERF-ESEY--P-RAVEC I-RNE--HYVDDM-LFSVE-T---EQEAISLAEQVR-YI-HSRG-------GFEIR-NWI SNSS-RV-MERV--QT---ITET---EKSFNM-----------------------GNE-F SA--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------SP APAFQRVGIDYCGPFE-------------------------------------------- ----------------------------LQPA--TRKS---API------KC-YIC---L -FVCMV--CKAVHAEVVMDLTADAF-----LAALRRF-VARR-GRPVEIFCDNATNFVGA RRQLS-E-------LDRMFRQE-QF------------------QDKLS---AKTAEDSIT ----FKFIPAKSPNFGGLWEAAVKSLKGHMRKVIG--N-----RLL----KPDEM----- --HTV-----VTQIEACLNSRP--------LTP------------L-------------- ----------------------SN--------DPA--D-------L-------------- ----------- >744/1-602 ----TKRSILSQIAKIFDPLGFLGPVLTTAKLLMRE-LWML-N----------I------ -NWDD-P-IPS--AIASRWKTFREELYSLQ---D-MDLP--RRF--I------------- --VDGAIKV-----ELHG-FSDASDN-ACG-ACVYAR--SIFL-DG------SSQL-R-- LMCS---------------------------KSKI-LPE--K-KKGK------------- ---PKY--------------------------ISTPRAELEAAL-LLA-NLVDKVTSA-- -LD-------YDF---DST---TL---------WS------------------------- -------------------------------------FYLPNHCV-------LKPS-STT TKL-RVVFDGSAESA-TG---ISLNQAQYAGPTVQ--DDLISILLNFR---SYRY--AVS ADIPKMYRQVVVHPE--DQPYQR-----I------LWRDD---N-SQ---------SL-K VLQLTTVTYGLKSSPFLATMS-LLQL------------V----KDE-GDAF--P-LADQA I-TKS--CYIDDM-LSGAD-S---IPELLELKQQLI-DC-LAKG-------GFNIH-KIC SNSN-EL-LEDTPIHQRETSQ------EIN---------------------------DRK LPT-------------------KT--LG-------------------------------- -----ITWEPQSDVFRISIPLQLGQELTKRSILSQIAKIFDPLGFLGPVL---------- ----------------------------------------------------------QP APIFATTGVDFAGPFI-------------------------------------------- ----------------------------FKSLTQARKP---MYT------KG-YVC---V -FVCMS--TRALHLEPVSNLTSEAF-----LAAQQRF-VSRR-GLPSKMISDNATNFEDA CNELE-R-------LAALFKEE-QF------------------QKKLD---QFCTQRSIE ----WSFIPPRSPHLGGIWEAGVKSVKSHLKLILA--E-----HKL----TFEEF----- --ATV-----LSQIEAVLNSRP--------LVP------------S-------------- ----------------------SD--------DPN--D-------I-------------- ----------- >745/1-518 ---PTKREMLKLVMSLFDPLGFMTFYLIHGRALIQD-VWAT-G----------V------ -DWDV-P-INH--DLCKKWWQWISFLPSVS---N-LKIP--RCY--F------------- -RGQIN----DRK-QLHI-FVDASDA-AYA-CVAYLR--GNG--DQ------GVEV-A-- LVGA---------------------------KSKV-APL--K-V---------------- --------------------------------LSIPRLELMAAV-IGS-RLADSVIAS-- -H------S-YDI---AET---YL---------WT------------------------- -------------------------------------WYLPLSVV-------VNPK-K-P NKV-RVVWDAAAK-V-DG---TSFNSVLLKGPDLL--TSLVAILYHFR---EHRI--AVT GDIEEMFLRILIRPQ--DSQSQR-----F------LWREN---S-GD---------E-PS VYIIDVATFGSTCSPSSAQFV-KNAN------------A----KEH-MESF--P-RAASA I-IRY--HYVDDY-LDSFE-T---EEEAIAVVNQVK-FI-HSTG-------GFNLR-NCL SNSE-EV-LLAI--EN-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFTFVGLDYFGPLT-------------------------------------------- ----------------------------VK--VG-R-----S-EV-----KR-WVA---L -FTCLT--VRAIHLEVVHSLSSESC-----ILAIRRF-IDRR-GAPAEFFSDNGSSFIGA NKQLQ-L-E------IAA-MNE-V----------------------LA---STFTNTNTR ----WNFNSPSAPHMGGVWERLVRSVKNAICTIID--A---P-RRP----TDEVL----- --ETI-----LFDAEAMINSRP--------LTY------------I-------------- ----------------------PL-------------ET--------------------- ----------- >746/1-523 ---PTKREVLRIVMSLFDPLGLIAFYLIHGRILMQD-IWAS-G----------I------ -DWDD-T-IKS--ELFERWRLWCSYLPQLS---L-LRIP--RCY--Y------------- -AGATQN-TYSTL-QIHV-FVDASEL-AYS-SVVYFR--VTS--YS------GVDT-V-- LVSA---------------------------KSKV-APL--K-M---------------- --------------------------------LSVPRLELQAAV-LGT-RLLNNVIDM-- -H------K-LQV---TKR---IL---------WT------------------------- ------------------------------------CWYLPLGVV-------VNAR-K-- NKV-RLIMDARAT-V-DG---VSLNSSLLKGPDMV--TSLPAVLCNFR---MFQF--ALA ADIKEMFHRIKIREE--DRQFQR-----F------LWRDR---P-DI---------E-PT IFVMDVAIFGSTCSPSSAQYV-KNCN------------A----KDF-AGVY--P-RGSEA I-IRH--HYVDDY-LDSFG-T---IEEAVTVGREVK-EI-HAKG-------GFEIR-NFL SNEP-EI-ARSI--GA-----QS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFTYVGLDYFGPVL-------------------------------------------- ----------------------------VK--QG-R-----S-NV-----KR-WVA---L -FTCLS--IRAVHMEVVHTLSTESC-----ILAIRRF-VARR-GPPAEIFSDNGTNFHGA NNILK-Q-Q------ITE-RNK-T----------------------LA---AIFTNGNTK ----WSFNPPGAPHMGGVWERMVRSVKMAIGTFIH--A---T-RKP----DDETM----- --ETV-----IIEAEGMINSRP--------LTY------------I-------------- ----------------------PI-------------ES--------------------- ----------- >749/1-566 ----TKRRILASVASLFDPSGLLGPTITAAKIFLQE-LWAW-R----------S-DEGDK IDWDE-P-VPL--MVGERWRRFHEKLPILN---D-IRIS--RCV--I------------- --IP-K-AV--SL-QLHC-FSDASQK-AYG-GCIFLR--SQNA-EV------RTSV-S-- LLAS---------------------------KSRV-APL-------K------------- ---C----------------------------QTIPRLELCGAL-LTA-QLFEIIQKS-- -I-K----I-D-----IPT---FF---------WS------------------------- ------------------------------IRDTVKRCYLPHHPV-------VNEA-STT TKV-RVVFDASCKTS-TG---ISLNDTLHVGPVIQ--EDLRSIVLRCR---TRQI--MLV SDIEKMFRQINVIQE--DRPLQS-----I------LWRKH---P-TE---------EI-A TYELGTVTYGTKSAPFLATRT-LHQL------------V----KDE-GQDF--P-LAAKA I-VED--TYMDDV-ITGAD-T---IEEATDLRKQLV-EM-LRRE-------GFRLR-KWA SNEG-AT-LQGLPQQELAIADSTE-I-GRD---------------------------Q-- -DPSV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TM ARPFSRTGVDYFGPVL-------------------------------------------- ----------------------------VRPG--PRRV---A-V------KN-YVA---V -FICMV--TKAVHLELVSDLSTDRF-----LQALRRF-IGRR-GRCTDIFSDNGTNFVGA KNRLK-E-------LFALLNDD-QH------------------KESVD---KFCTNQGIR ----WHFNPPNAPHFGGLWEAAVRSTKHHLLRVVG--E-----HAM----STEDF----- --QTL-----LIQVESCLNSRP--------ITP------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >75/1-568 ----TKRCVLSDASRLFDPLGLVGPVIIQAKIFLQD-LWKH-D----------C------ -EWDE-P-LSP--QLEDQWREYRRNLTGLD---G-IAVP--RWV--G------------- --TSRS-TE--AV-ELHG-FCDASNK-AYG-ACVYVR--AVAA-DG------SVMV-H-- LLTS---------------------------KSRV-APL--E-NLKK------------- ---NKKS-------------------------LSIPRLELSSAL-LLA-HLYEKVAKN-- -I-T----V---A---TKC---RF---------WT------------------------- ------------------------------EDTSAPSYYLPHHAV-------LKPD-STT TKL-RVVFDASCKTS-TG---VSLNDALMVGPVVQ--DMIVDITLRFR---THRF--ALV GDVAKMYRMVLMNAA--DQQLQR-----I------VWRDS---P-SE---------SI-R TFALTTVTYGTASAPYLATKC-LQRL------------S----EEG-EESH--P-AAAKV L-KKD--FYVDDM-LSGVD-D---IEEGKRLVSQMN-DL-LQSA-------GFSLR-KWN SNSK-EL-LSAVPEGLRDERS--I-L-ELD---------------------------S-- SSAAV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------RP CFPFQKVGVDYCGPFY-------------------------------------------- ----------------------------VVYP--QRRA---RPV------KC-FVA---V -YVCLV--TKAVHLELAADLSTQAF-----LATLQRF-TARR-GKPSLIMCDNATNFVGA RRKLD-E-------LAQLFASQ-QF------------------TEAVL---RQTIEDRIE ----FRFIPARSPNFGGLWESAVKSFKTLFKRTIG--T-----RSL----EYDNM----- --LTV-----LAQAESILNSRP--------LTP------------I-------------- ----------------------SN--------DPD--D-------F-------------- ----------- >750/1-558 ---PSKREMLKLVMSLFDPLGFLAFYLIHGRILIQD-VWAT-G----------V------ -GWDT-P-VNS--ELAQRWWQWISFLPSLN---K-VQIP--RCY--F------------- -HGYMD----NSK-QLHV-FVDASDA-AYA-CVAYLR--AVG--TA------GVEL-A-- IVGA---------------------------KSKV-APL--K-V---------------- --------------------------------LSVPRLELMAAV-IGA-RMVESVVTS-- -H------S-YTI---TDV---FL---------WS------------------------- -------------------------------------WYLPLCVV-------VNPK-K-P NKV-RVVWDAAAK-V-NG---VSFNSALLKGPDLL--TSLTSILYHFR---EYRI--AVT GDIEEMFLRILIRPE--DSRSQR-----F------LWREN---P-GD---------N-PS VYIIDVATFGSTCSPSSAQFV-KNAN------------A----KDY-REKF--P-RASSA I-IKY--HYVDDY-LDSFD-T---VEEAIEVVKQVK-SI-HSEG-------GFNLR-HFL SNSN-DV-VLAV--SEAIGNDSDED-TKQFNI-----------------------V-RDE KI--E-----------------SV--LG-------------------------------- -----MKWNPSRDVFVYTL----------------------------------------- ----------------------------------------------------------PF VRPFTFVGLDYFGPLI-------------------------------------------- ----------------------------VK--VG-R-----S-EV-----KR-WVA---L -FTCLT--VRAVHLEVVHSLSSESC-----VMAVRRF-IARR-GTPAEFFSDNGTSFVGA NKQLQ-R-E------IAS-RNE-V----------------------LS---STFTNTNTR ----WHFNPPGAPHMGGAWERLVRSVKSAIGMIID--T---P-RRP----TDEVL----- --ETI-----LLDAEAMINSRP--------LTY------------I-------------- ----------------------PL-------------DT--------------------- ----------- >754/1-546 ---PTKREVLKVVMSLFDPLGCISFFLVHGKILIQE-TWIS-K----------I------ -GWDD-P-IGE--SSLARWKQWTGFFEQLA---S-LRIP--RCY--F------------- -RSPFPS-SFDLL-QLHI-FVDASES-AYS-CVAYFR--LPV--RE------QVQV-A-- MVTA---------------------------KTKV-API--N-T---------------- --------------------------------ISVPRLELKAAV-LGT-RLLESVKQN-- -H------T-IPI---PQF---FL---------WS------------------------- -------------------------------------WYLPLGVV-------INAK-K-S SKL-RLIWDASAK-V-GD---VSFNSKLLKGPDLL--TPLPAVLSRFR---QHQV--AVT GDIKEMFHQIKIRKE--DQHSQR-----F------LWREH---P-SE---------T-PQ IYVMQVATFGSTCSPASAQFV-KNRN------------A----QEF-AEQY--P-RAALA I-HEN--HYVDDY-LDSFQ-T---IQEAVQVVNEVK-LV-HSLG-------GFEIR-NIL SNSA-DV-LRMV--GEL----PSDN-SKNLLL-----------------------S-RGE ST--E-----------------SV--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------PF FRPFTYVGLDYFGPVF-------------------------------------------- ----------------------------VK--VG-R-----S-QA-----KR-WVA---L -FTCLT--IRAVHLEVVHSLSTVSC-----IMAIRRF-VSRR-GTPAEFYTDNGTCFQGA SKELA-N-E------IKS-RNE-T----------------------IA---LTFTSAQTK ----WNFIPPSTPHMGGAWERLVRSVKAAVGTILD--S---P-RRP----DDETL----- --ETI-----LFEAEAMINCRP--------LTY------------V-------------- ----------------------PL-------------KS--------------------- ----------- >755/1-547 ---PTKRQMLKCVMSIFDPLGLVASFLIHGKVLMQD-VWRT-G----------I------ -KWDE-H-VAD--KVYDQWQRWIAVFERLK---T-IQVP--RCY--F------------- -KEANNE-VYRST-QIHV-FVDASET-AYA-AAVYFR--TLQQ-DG------APQC-S-- LVTA---------------------------KAKV-APL--K-Y---------------- --------------------------------HSIPRLELMAAV-LGT-RLLSFVQQG-- -H------SQLTA---PTC---FL---------WS------------------------- -------------------------------------WYLPLGTV-------TNPK-K-T EKV-RLVWDAAAR-T-NG---ISLNSVLISGPDLL--TPLPFVLFRFR---LFPY--AIS SDITEMFHQIEIIPT--DRHSQR-----F------LFRNE---P-TD---------A-PT IFLMDVATFGATCSPTIAQFV-KNEN------------A----KEF-AEQY--P-RAVDG I-VKG--HYVDDY-LDSFA-T---IEEAKKVAAEVR-QI-HSEG-------GFFLH-NWA SNAP-AI-LAHL--GEL----PKSG-AKNLTA-----------------------A-KVD NS--E-----------------RV--LG-------------------------------- -----MQW---------------------------------------------------- ----------------------------------------------------------PF VRPFSYVGLDYFGPIL-------------------------------------------- ----------------------------VK--LG-R-----S-NV-----KR-WIA---V -FTCLT--IRAVHVEVAFDLTTQSC-----INCIRRF-VCRR-GAPTEIHSDNATNFIGS DSVLQ-S-Q------IQK-INQ-E----------------------SS---ATFTNASTK ----WVFIPPSSPHMGGAWERLVRSIKVAMMNL-S--Q---T-RKM----DDEAL----- --QTV-----VVETEAIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >758/1-555 ----TKRKIFSTIAKLYDPLGLVSPVVSWAKIHMQQ-LWTK-N----------T------ -GWDD-P-IPD--DITVKWKDFSSQLPCLV---G-YKVP--RYL--F------------- --LP-D-SS--SV-QFHV-FTDASEA-GYG-ACIYAR--TVDL-KG------NIKI-E-- LVAA---------------------------KSRV-APL-------K------------- ---R----------------------------ISLPRLELCAAL-LGA-KLYARVSTA-- -L-R----M-E-G---TRC---CF---------WT------------------------- -----------------------------------MVYYLPHHPV-------FKES-SST TKV-RVVFDGSAKST-TN---YSLNDALLTGPNIQ--DELLDLMIRFR---RYPV--AIV ADVAKMYRQIRVHEN--DTSLQR-----I------VWRFN---T-AA---------PL-Q VYELQTVTFGLAPSSFLATRV-LKQL------------A----LDS-SDKY--K-FTCDP V-QED--FYMDDF-LSGAD-S---VEKAIELRKEMQ-TL-MAEG-------GLELR-KWC SNKV-EV-LYNIPNESLGDVS--T-L-HFD---------------------------D-- -SQKV-----------------KT--LG-------------------------------- -----VGW---------------------------------------------------- ----------------------------------------------------------TP SRAFTITGVDFCGPVY-------------------------------------------- ----------------------------LKPA--HRRA---AAR------KA-FIA---V -FICFA--SKAVHLELVCDLSSEAF-----IAALRRF-ISRR-GIPTEIHSDNGTNFRGA NNTLI-E-------LYRLLENN-HT------------------REAII---KECNLKRIQ ----WYFIPPRAPSFGGLWEAAVKTAKTSLAKTLG--N-----TQL----SYEDF----- --VTV-----LTQIEANMNSRP--------LTS------------L-------------- ----------------------SN--------DPG--E-------L-------------- ----------- >760/1-541 ---PTKRSVLSYIGQLFDPLGFLGPIITTAKLIMQD-LWRL-G----------L------ -SWDQ-P-LPQ--QQMEEWQEFRQQLPMVN---E-MKKK--RCV--V------------- --AE-T-GN--DV-ELHG-FSDASTR-AYG-AVLYTR--CVSA-DG------SIYT-E-- LVCS---------------------------KSRV-APL-------K------------- ---P----------------------------TTIPRLELCGAL-LLA-HLVTKTVAA-- -M-K----I-P-F---KSV---TL---------WC------------------------- -------------------------------------HFLPHHAV-------YKEA-SST TKL-RVVFDASSKTT-SG---LSLNDALNVGPTVQ--SDLLSIILRFC---SHQV--VLT ADIPKMYRQVRVHEA--DRYYQR-----I------LWLNN---K-NE----------I-A TFELATVTYGCSSAPYLATKV-LLQL------------A----KDE-EHDL--P-LAAKI V-IED--SYIDDF-LTGGK-T---AEEVIQIYHQLS-DM-LKRG-------GFGVH-KFC SNDA-TV-LSNIPEELQETRM------DFE---------------------------NAD VNTTI-----------------KT--LG-------------------------------- -----IIW---------------------------------------------------- ----------------------------------------------------------TP SPVFANTGVDYAGPIV-------------------------------------------- ----------------------------LK--EAGRKT---VPY------KA-YIA---V -FIYLA--TKAIHLKVVSNLTTDNF-----IAALQRF-VSRR-GMISNIYSDNGTTFVGA NHELA-A-------LRTLFEDQ-IH------------------QRKLN---DFCITKGIQ ----WHFIPPRSPHFGGIWEAGVKSAKYHLKRGWS--A-----EYL----HH-------- -----------------LQSRP--------KWH------------N-------------- ----------------------GI--------TKF--E-------V-------------- ----------- >762/1-547 ---PTKREVLRIVMSLFDPLGLITFYLIHGRILMQE-IWSA-K----------I------ -DWDD-V-LNK--ELCERWRLWIRYLPQLD---T-LRIP--RCY--F------------- -AGGNQE-TYGTL-QIHV-FVDASES-AFS-SVAYFR--VNT--TS------GADV-I-- LVSA---------------------------KSKV-APL--K-M---------------- --------------------------------LSIPRLELQAAV-LGT-RLLNSVIAM-- -H------G-LQV---TKR---VL---------WT------------------------- ------------------------------------CWYLPLGIV-------VNQR-K-- NKV-RLIMDARAA-V-DG---VSFNSSLLKGPDLL--TSLPAVLSHFR---LYQY--ALA ADIKEMFHRIRIREE--DRQFQR-----F------LWRDQ---P-HM---------E-PT TFVMDVAIFGSTCSPSSAQYV-KNLN------------A----QDF-ASEF--P-RAADA V-VRH--HYVDDY-LDSFG-T---MEDAVMVGREVK-EI-HARG-------GLEIR-NFL SNKA-EI-AERV--GA-----QSLAMEKIFQA-----------------------GKDEE YA--E-----------------SV--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------PF VRPFTYVGLDYFGPIL-------------------------------------------- ----------------------------VK--QG-R-----S-NV-----KR-WIA---L -FTCLS--IRAVHLEVVHTMSTESC-----ILAIRRF-VTRR-GAPAEIFSDNGTNFHGA NNKLQ-K-Q------IQE-RNQ-T----------------------LS---AIFTNTNTK ----WSFNPPGAPHMGGAWERMVRSVKVAMGTIAE--A---T-RKP----DDETL----- --ETV-----IIEAEGIINSRP--------LTY------------I-------------- ----------------------PM-------------DS--------------------- ----------- >763/1-557 ---PTKRIALRCVMSMFDPKQFLAPLLIHGRILMQD-LWRS-G----------I------ -GWDE-K-IGQ--VHYKQWLRWTGLFPLIN---N-IRVP--RCY--L------------- -GEMSHS-AYDSV-QLHV-FTDAGED-AYG-CVAYFR--IVDD-KN-------VHC-A-- FVEA---------------------------KAKV-APL--Q-Y---------------- --------------------------------LSIPRKELEAAV-LGA-RLLKTICEN-- -H------S-VNV---KKC---YL---------WT------------------------- -------------------------------------WYLPLSYV-------VNPK-K-P GKI-RMVWDAAAK-A-NG---VSFNDSLLKGPDMV--ASLSTVINGFR---ERRV--AFG GDIREMFHQIFVRHE--DRQAQR-----F------LFRYD---V-NC---------E-PD IYVMDVVIFGASCSPCLAQFV-KNMN------------A----LEH-LQQY--P-AAADA V-IRK--HYVDDY-FDSVD-T---EDEAIERAKDVR-TI-HAQA-------GFEIR-NWM SNSP-KV-LAEL--DS------SYESKEAKSL-----------------------DRNNT DS--E-----------------KV--LG-------------------------------- -----VMW---------------------------------------------------- ----------------------------------------------------------VS EHPFAYVGLDYFGPLE-------------------------------------------- ----------------------------VI--VG-R-----R-RE-----KR-WVA---L -FTCMT--VRAIHLEEVYSLTTKSC-----EMAIRRF-VKRR-GSPIEIFSDNGTNFVGA SRDLA-E-Q------IRT-INI-E----------------------CA---DTFTGTRTK ----WTFIPPSAPHMGGVWERMVRSVKEAMSA-LM--N---G-ERL----TDEIL----- --QTA-----LVEAESLINSRP--------LTY------------V----STNVKEDKEA LTPN---------------------------------HF--------------------- ----------- >764/1-552 ---NTKRQLLSDSSKLFDPFGWIAPVVVKTKILFQY-LWLY-D----------L------ -GWDD-P-LPA--TIRDEWIELKETLYRIE---R-IRIQ--R-W--I------------- -PHSMGR--L----QLHG-FADASEA-AYA-AVVYAR--SVDQ-DG------RIHT-N-- LVAA---------------------------KTKV-API--Q-Q---------------- --------------------------------VSLPRLELMAAE-LLS-DLMIKLMES-- -F------S-HLD---VEL---YA---------WS------------------------- ------------------------------AISPEKCFYLPHNAV-------WKDV-STT TKF-RVVFDASSKTA-SG---ISLNDRLLVGPNIN--EPLFNVFARWR---TYKI--AFC ADVQKMYRQVLISRE--DADFQR-----I------VFRED---P-DQ---------PL-D HYRLLTVTYGIASAAYQAVAT-LHQI------------A----ADN-QELH--P-LAASR I-PKN--FYVDDL-LSGAD-T---VEEAEFLRDELI-EV-LGSG-------GFALR-KWS TNEA-QI-LD-SETSHDEIVSVEL-PNEGD------------------------------ ---SI-----------------KA--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------MP ARPFLHCGVDYAGPLM-------------------------------------------- ----------------------------IRTS--NLRT---AKST-----KG-YVA---I -FVCLS--TKAIHLEAVTDLSTSAF-----LAALKRF-ISRR-GLCAELWSDHGSNFVGA DKEIR-K-------HLRSDEFN-E---------------------AVS---RYLTNMRIK ----WTFITPSAPHMGGIWEAAVKSMKKHLRVVLG--N-----TTF----TFEDL----- --STV-----LAQIEACLNSRP--------LCP------------I-------------- ----------------------S--------------T---------------------- ----------- >765/1-559 ----TKRLVLSEMXRLFDPMGLVGAIIVSAKIFLQA-LWLE-K----------F------ -DWND-V-LPG--DYQAWWIQFRTEITRLS---P-FRIP--RRI--L------------- --AS----DNQLL-ELHV-FSDASDH-AYG-CCVYVR--SISS-TG------QQYC-N-- LVMS---------------------------KSRI-SLF-------H------------- ---K----------------------------LSIPRLELCAAV-LGA-QLAEYVLDS-- -T-N----W-K-----CPV---TF---------WT------------------------- ------------------------------FPPSIPHFYLPHHAI-------QRPD-STT TKT-RVVFDASCRGS-NN---VSLNDLCYVGPTVQ--PPLISTLINFR---LPRY--AVS ADAEKMYRQVWVDPE--DCMLQL-----I------LFRKN---P-TE---------KL-K TYRLKTVTYGTAPAPYLATRV-LNQL------------A----EDE-ADKY--P-LAAPK V-VKC--FYVDDY-LSGDD-N---EQRLVETNCQLI-EL-LRSG-------GFNMR-KWC SNSP-TV-LSNIPESLRDSRT------TLE----------------------------IS QSDSV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TP SRAFTHCGVDYCGPFS-------------------------------------------- ----------------------------VSIP--NRRG---PSV------KV-HVA---I -FVCMS--SKAVHIDMVYNLTSDSF-----INILKRL-VGRR-GRVSDIYCDNARTFVGA NRILE-E-------NRKQFDAM-HQ------------------SQGLH---TFCAETGIN ----FHFNPARSPHCGGLWEASVKTFKYHLYRVMK--D-----TVI----NTDDF----- --STL-----IIQIEGIMNSRP--------LCP------------L-------------- ----------------------SS--------DPA--D-------V-------------- ----------- >767/1-569 ----TKRSVHSDAACFFDPLGLVGPVVVQAKIFIQR-LCLL-K----------C------ -GWDD-P-LDE--SLQDLWKEYKQNMIALE---S-LSIP--RWL--G------------- --VSND-CA--DV-QLHG-FCDASEA-AYG-ACLYLR--CTAS-DG------TVTV-R-- LITS---------------------------KSRV-APL--E-NLQR------------- ---KKKK-------------------------ITIPRLELSSAL-LLS-HLYEKY-NQ-- -V-R----P---N---LAA---FF---------WT------------------------- ------------------------------QRTANPVYYLPHHAV-------LRPD-STT TKL-RVVFDASCKTS-TG---ISLNDALMVGPVVQ--NDLISTILRFR---HHRI--AVT ADVAKMYRMVRVPEQ--DQHLQR-----I------LWRDT---P-EE---------PV-K TFELLTVTYGTASAPYLATRC-LREISVSFQFXYMSCRS----KDS-VSTH--P-IASRV V-QED--FYVDDM-LSGAD-T---VNQTRKLMNEVI-EL-TNTV-------GFTLR-KWN SNSA-GL-LSKLPKHLRDERT--V-L-DLD---------------------------S-- SNATV-----------------KT--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------AF SRPFTHVGVDFFGPYE-------------------------------------------- ----------------------------IA--IG-R-----R-TE-----KR-WGM---L -ATCMT--TRAIHIEVVHSLNTGSC-----VMALRNF-ISRR-GRPRTIYSDRGTNFIGA NREIK-E-------ARHLVDQE-E----------------------LM---NEFIDSETS ----WEFLPPSSSHMRGSWERLIGCVKKNLMVILP------T-RKL----TDEVL----- --RNR-----LTEIENTVNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >769/1-564 ---PTKREVLKAVMSLFDPLGLLSALVVQGKCIIQD-IWRS-N----------I------ -GWDE-K-IPE--EIFLRWCRWLNVFKEVD---Q-ITIP--RCY--F------------- -LNYSNK-SLDTL-ELHV-FVDASEE-AFA-CVGYFR--IVD--RG------QVRC-A-- LVSA---------------------------KSKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-IGS-RLVKSIQEN-- -H------T-LPI---RRR---VI---------WS------------------------- ---------------S---------------FDPRRIWYLPLGIV-------LNPN-K-P GKI-RLVWDAAAK-V-DG---VSFNSMLLKGPDLL--TSLPAVLQRFR---QRQI--TVT GDIREMFHQLLIRPE--DRQSQL-----F------LWRDH---P-ST---------D-MH TYVMNAATFGSTCSPCSAQYI-KNRN------------A----EEL-KNEF--P-EATDA I-IFN--HYVDDY-LDSMD-S---VEEATKIATSVK-EV-HAKA-------GFEIR-NWL SNST-EV-VRQV--GEGKTSV----DTKSIAA-----------------------D-KST DA--E-----------------RI--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------PY VRPFSFVGVDYCGPFF-------------------------------------------- ----------------------------IR--IG-R-----S-NV-----KR-WVA---L -FVCQT--VRAVHLEVASSLSTESC-----KMAVRRF-IARR-GSPRRIYSDQGTNFHGA RKELA-Q-E------MTS-INQ-K----------------------LA---ETFTNINTQ ----WILNPPAAPHMGGSWERLVRSVKTGLEV-LS--K---S-RNP----DEETF----- --GTV-----LAEVEAIVNSRP--------LTH------------V-------------- ----------------------AL-------------DSEEDEALTPNHF---------- ----------- >77/1-557 ---PTKRTILSAIAQLYDPLGIISPVVVQAKILMQH-LWLI-A----------L------ -DWDD-I-VTP--DLQRKWAEFCKQLPGLA---N-FRIE--RFA--F------------- --AP-G-FH--VA-ELHC-FADSSEV-AYG-ACIYVR--SQAA-DG------HVQV-S-- LLAS---------------------------KSKV-APL-------K------------- ---P----------------------------LSIPRLELCAAL-LAA-RLFEKIVGS-- -L-E----M-K-F---SES---FF---------WS------------------------- ------------------------------EECDMKVCYLPHHPV-------IKES-STT TKV-RVVFDGSAKTS-SG---YSLNDSLLVGPVVQ--DELLNLVIRFR---TFPI--ALV ADIEKMYRQVSMNPA--DRPLQR-----I------LWRFD---T-SQ---------PI-Q TYELSTVTYGLAPSSFLATRT-LLQL------------V----DDE-GSSF--P-KASTA I-KKN--VYVDDL-ISGDK-S---IEETIQLREELT-SL-LQKG-------GFRFR-KWC SNSL-PV-LAGLPPDLLGTQS--S-L-KFD---------------------------P-- -EESI-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ------------------------------------------------------------ --AFLCTGVDYCGPVF-------------------------------------------- ----------------------------LKPV--HRKA---AAR------KC-YIC---V -FICLS--TKAVHLELVSDLSTAAF-----LMALDRF-MWRR-NKPQHLYSDNGTNFIGA KNALH-K-------VYQMLQPG-PD------------------NERIS---KRLAEDGIQ ----WHLIPPRAPNFGGLWEAAVKVAKIHLVRQLG--S-----SLL----SFEEL----- --TTV-----LIKIEGCMNSRP--------LVP------------L-------------- ----------------------ST--------DPN--D-------L-------------- ----------- >770/1-552 ---PSKREVLRVVMSLFDPLGLISYYVIHGKTLMQD-IWAS-G----------V------ -NWDE-P-IST--ELCEQWCRWTALLPELN---S-IRIP--RCY--F------------- -VAADYS-SYASL-QIHV-FVDASKS-AYA-CVVYFL--VES--EE------GPAV-S-- LVAG---------------------------KAKV-APL--K-I---------------- --------------------------------MSIPRLELQAAV-LGT-RLLNSVVAM-- -H------N-LPI---SRR---VL---------WT------------------------- ------------------------------------------------------PR-K-P NKV-RIIWDAAAK-V-NG---VSLNSVLLKGPDYL--TSLIEVFYHFR---LYAV--ALT GDIKEMFHRLFIKRE--DRQFQR-----F------LWRDN---G-SS---------N-VE VFVMDVAIFGATCSPSSAQHV-KNMN------------S----KEF-ENEC--P-RAAAA I-IRF--HYVDDY-LDSFP-T---AAEAVEVGSEVR-RI-HAAG-------GFEIR-NFL SNDA-SV-AERV--GA-----ISNEAGKTIKP-----------------------E-KND NV--E-----------------SV--LG-------------------------------- -----MKWIPAEDVLTYTFLVRAD------------------------------------ ----------------------------------------------------------SF VRPFTFVGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NA-----KR-WIA---L -FTCLS--IRAVHMEIVHSMSTESC-----IQAIRRF-VSRR-GSPAEFFTDNGTNFHGA NNQLK-R-E------IEE-RNR-K----------------------LA---SVFTNSNTR ----WSFNPPGTPHMGGVWERLVKSVKDAIKLTLD--E---S-RNP----DDETL----- --ETV-----IIEAEGMINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >773/1-558 -----KRVILSDFARLFDPLGLVGPVVVQAKIFLQD-LWKQ-K----------C------ -SWHE-P-LSE--DLQHWWLDFRKNLATLS---T-LTVP--RWL--A------------- --FGSD-TI--SA-EIHG-FCDASEK-AYG-ACIYLR--CTCF-NG------QVSV-S-- LIAA---------------------------KSRI-APL--D-DVRH------------- ---KRKK-------------------------MSIPRLELSSAL-VLS-HLHEKVENS-- -L-R----I---K---AQS---FY---------WT------------------------- ---------------------------------------LPHHAV-------LRPE-STT TKL-RVVFDASCATM-SG---VSLNDALMVGPVVQ--EDLLSIVLRFR---LHKF--AIV ADVAKMYRMVNIASE--DQRLQR-----I------LWRDS---S-SE---------PV-R TFELTTVTYGTSSAPYLATKC-LQRL------------A----EEG-ALEY--P-VASKI L-SED--FYVDDM-LSGAD-S---IDEGIKMYQELT-QL-LETS-------KFTLR-KWS SNSP-EI-LAAIPEHLKDDRT--S-L-ELD---------------------------S-- SKAAI-----------------KT--LG-------------------------------- -----LSW---------------------------------------------------- ----------------------------------------------------------CP APPFIRVGVDYCGPFK-------------------------------------------- ----------------------------IRFP--HRKS---DIR------IC-YVV---I -FICLV--TKAVHIDMVADQTTEGF-----IAALRRL-VARR-GRPDVVMCDNARYFIGA KRELD-Q-------LRRLFNSQ-AF------------------TNSIP---QAAANEGIN ----FKFIPPRSPNFGGLWEAAVKSLKYHLKRVVG--N-----NVV----TPDEF----- --YTL-----LTQIEACLNSRP--------LTP------------I-------------- ----------------------SN--------EPS--D-------L-------------- ----------- >775/1-529 ---PTKRQLLQFMMGIFDPLNILSPVTIHLQILFQD-LWRL-Q----------I------ -AWDD-Q-IPE--GLIPKWTEWLQKTAQLK---E-ITIP--RYY--F------------- -PGVPS---FRSV-ELHA-FSDASDK-AFA-TVIY----MVHRYPD------KSHV-A-- LVLA---------------------------KSRV-AHL--K-S---------------- --------------------------------RTVPRLELQGCV-LSS-QMMKVVQEE-- -L------E-VEI---TST---YF---------WT------------------------- -----------------------------------NTWYLPHFSV-------MTAN-K-- --F-RLVMDAKAK-S-HG---FSLNDLLLKGPDFV--PSLTAVLMRGR---QKKV--AFM ADIKEMFHQVRIREQ--DQNSQR-----F------FWRGM---NRST----------PSE VYVMMAMIFGAVSSPSIAQFI-KNFN------------A----KEL-EERL--P-GVLRP I-VIQ--HYVDDY-FDSTD-T---EQQA---IKNVI-TA-HEHG-------GFKLV-KFV SNSE-AV-LNSL--------------DPSLRA--------------------------EP KTD-V-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------PF AFPFTHTGIDCFGPLT-------------------------------------------- ----------------------------VK--VG-R-----H-VE-----KR-WVV---L -FTCMT--SRALHLEVVPSLDANSC-----IMAIRCF-MAIR-GIPQKILTDNGTNFTGA NQELK-K-------FVKELDQQ-Q----------------------IE---ETLSVRGIE ----WSFIPPGAPHFGGCWERLVRSVKTGMRAMLK--K-----RNP----TDLVL----- --RTT-----LCEVMNVVNNRP--------LTE------------V-------------- ------------------------------------------------------------ ----------- >779/1-556 ---PTKRIILSNIASLYDPLGLNAPIIINAKQLMQR-LWEL-K----------V------ -DWDT-T-PPG--EVINIWQSFVQSLAQLN---L-FQIP--RRV--I------------- --GTTR-TS--QI-YLHG-FSDASER-AMG-ACVYVR--TIDD-VG------NLNS-H-- LLCA---------------------------KSKV-API--G-NKR-------------- --------------------------------ATLPRLELCAAV-ILA-RLIDSVVKA-- -V-E----Q-P-F---VEI---RA---------WV------------------------- ---------------------------------------LPHHCV-------VKET-STT TKC-RVVFDASAKTN-NG---KSLNDILMTGPVLQ--DSLVNISLRFR---FPSV--VLA GDVKQMYRMVLLCDH--HRDICR-----I------LWRWS---R-DE---------PM-L EYCLNTVTYGTKSASYLATKC-VQQL------------L----LAH-EKQF--P-TTVAR A-IKG--TYVDDV-LTGAD-S---IGEAKQLCQELR-HI-FAAG-------GFHLR-KWA SNNV-EA-LEGIPEEDREMKQ------PID----------------------------LN EPNTI-----------------KA--LG-------------------------------- -----IHW---------------------------------------------------- ----------------------------------------------------------HP NPAFAVTGIDYAGPVQ-------------------------------------------- ----------------------------IVDR--RTRG---AKSS-----KG-YIA---L -FVCFS--TKAVHMEAVSDLTTTSF-----LAAFTRF-YSRY-GLPAKVYSDNATTFRAA SKHFQ-E-------MYDLVNSS-VH------------------NDRAT---DFLTDKGVE ----WSFIPARSPHHGGLWESAIKVAKQHLSKLTS--N-----YIF----TFEEL----- --STF-----ISQIAATMNSRP--------LTP------------I-------------- ----------------------SN--------SPV--D-------A-------------- ----------- >780/1-563 ---WTKRRIFSAIAQLYDPLGLVSPVVAWAKIRMQH-LWLA-S----------V------ -DWDD-P-VPE--DISLKWQDFYEQLPLLR---T-FKAP--RFV--F------------- --AF-D-PD--EI-QFHV-FSDASEV-GYG-ACLYAR--STGK-GG------LIKS-E-- LISS---------------------------KSRV-APL-------K------------- ---R----------------------------ISLPRLELCAAL-LGA-KLYARVSAA-- -L-G----M-E-G---VPC---WF---------WS------------------------- -------------------------------------CYLPHHPV-------FKES-STT TKL-RVVFDGSAKTS-TN---RSLNEALLTGPVIQ--DDLLDLMLRFR---KYPV--ALV ADVEKMYRQIRIHPE--DTPLQR-----I------IWRFD---P-AE---------PI-K IYELQTVTYGLSPSSFLATRV-LQKL------------A----EDV-GKRY--E-IAAPR V-MKD--FYMDDF-ISGAN-S---VEQARKLRKDVQ-AL-MSEG-------GLQLQ-KWN SNRP-EV-LDDKPDD--NIPL--T-M-HFD---------------------------S-- -DQKV-----------------KT--LG-------------------------------- -----VSWETESDQFGIEV----------------------------------------- ----------------------------------------------------------TP SRPFSITGVDYCGPVY-------------------------------------------- ----------------------------MKPI--HRRA---APQ------KA-FIA---V -FVCFA--TKAVHLELVCDLSTEAF-----IAALRRF-IARR-GLPTEMYSDNGTNFQGA KNTLA-D-------LYELLNDS-HH------------------QQRTI---DECSKNGIK ----WRFIPPRAPNFGGLWEAAVKTAKTSLSKTIG--N-----ARL----SYEDY----- --VTV-----LTQVEANMNTRP--------LTP------------L-------------- ----------------------SE--------DPD--E-------L-------------- ----------- >781/1-578 ----TKRSVVSEMSQLFDPLGLLGPVVVSAKIFVQR-LWAK-Q----------F------ -SWDE-S-LPK--EETDWWKNFRSELVQLK---N-VTVS--RCV--R------------- --SS----CNENY-QLHC-FCDASSK-AYG-CCDFVV--GPND-RG------RIEC-R-- LLIA---------------------------KSRV-APL-------R------------- ---G----------------------------LSIPRLELCAAV-LGS-ELVHNLLAT-- -T-N----F-S-----SPV---TF---------WS------------------------- ------------------------------SRVAGPQFFLPHHAI-------RRPD-STT TKT-RVVFDASSKSH-GQ---LSLNETLFTGPTVQ--PSLLAIVLNFR---IPKY--VFS ADVEKMFRQVWIHPD--DRRFLQ-----V------VWRPD---A-TV---------PL-K TYQLKTVTYGLACSPFQAARV-LNKL------------A----DDE-GDKF--P-LAAPI V-TKC--FYVDDV-LGGGD-D---LDKTAESCRQLQ-DL-LSQG-------GFSLR-KWS TNHP-KV-LQQIPEELRGTSS------LTE----------------------------IG KSAST-----------------KA--LG-------------------------------- -----LLWNPSTDLFGFQV----------------------------------------- ----------------------------------------------------------VP SRVFSRSGLDYCGPFN-------------------------------------------- ----------------------------VRPL--YGRG---ANI------KM-YVA---I -FVCLA--VKAVHFEIVTDLTTAAC-----INAIKRF-VARR-GRLTELHCDNGTAFVGA DRELN-A-------LHRRYLEQ-FQ------------------SDEWT---NYCVEAGIT ----FRFIPARSPHFGGLWEAGVKSFKFHFRRIFG--G-----KSY----TFDEF----- --STA-----AVHIESILNSRP--------LTP------------L-------------- ----------------------TD--------HPD--D-------LNVLTPGHF------ ----------- >783/1-542 ---PTKREVLSEIARLFDPLGVLGPIVVLAKMVLQQ-LWRK-M----------I------ -DWDD-P-IPD--EELDIWSRLRSELCSVN---D-MEIP--RRV--T------------- --ID-N-PT--TF-ELHG-FSDASTK-AYG-CCVYLK--TVAA-DG------MVEV-R-- LLCG---------------------------KSRV-APL-------K------------- ---ESERKERDGAAPAE---------------MTVPRLELCAAV-LLA-RQMKTVRET-- -V-D----V-D-I---NRV---VL---------WS------------------------- ---------------------------------------LPHHCV-------LKPE-SST TRL-RVVFDASAKTT-ND---LSLNDILMDAPTVQ--YPLFDIILQWR---LHKF--VFS ADIQRMYRQIVVDEA--HTKFQR-----C------LWRDD---R-TQ---------PI-K DLELSRVTYGIGPAGFLATRC-LVQL------------A----DDE-REGY--P-EANAV L-LKT--FYVDDA-LSGAS-T---LEEARRLREDLQ-LL-LNKG-------GFKLH-KWC ANDP-QI-LDGVPV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TI AQPFEKTGVDYAGPFM-------------------------------------------- ----------------------------IK--QGGSKA---P-I------KA-YVC---L -FVCMC--TKAIHMELVSSMTTDGF-----LGALQRF-VARR-GNVSDIYSDNGSNFIGA RRELQ-E-------FLHLLKSQ-IL------------------EEKVT---SFCQPRGTN ----WHFMPPRAPHQGGLWEAGVKAMKTHLYRTLKGPE-----AYL----TYEEM----- --VTL-----LVQIEAILNSRP--------LVE------------Q-------------- ----------------------SN--------DPT--D-------F-------------- ----------- >785/1-562 ---PTKRQVLRVIMSVFDPLGLIAHFVIHGKILMQH-IWRA-G----------T------ -NWDE-E-IPA--HLRQSWTTWXNYLPNLK---E-IQIP--RCL--L------------- -GFLRSE-KSITS-ELHV-FVDASRE-AYA-CAIYLR--TMG--TS------GVEC-S-- LIVA---------------------------KSKV-APL--K-P---------------- --------------------------------TSIPRLELQAAL-IGV-RLMEHVQQS-- -L------T-IRI---TRR---IF---------WS------------------------- ---------------S---------------ADPRRTWYLPLGVV-------QNPR-K-P SKV-RLIWDAAAS-V-KG---LCFNDLVLKGPDLT--TSLIAVLIRFR---QRNI--AIG GDLREMFHQIAIRPE--DRQFQR-----F------LWRRH---Q-NE---------S-PQ VLVMDVAIFGASCSPCIAQFI-KNKN------------A----SEL-LDEY--P-RAAQA I-IDN--HYVDDY-LDSVD-T---VGEAVELMEQVK-YI-HANG-------GFEIR-QFV SNSK-EV-LRNL--GV-EGSM----ADKNLNL-----------------------E-TE- -S--S-----------------RV--LG-------------------------------- -----MFW---------------------------------------------------- ----------------------------------------------------------PF VKPFTYVGVDYFGPMM-------------------------------------------- ----------------------------VK--VG-R-----S-QV-----KR-WVA---L -FTCLS--IRAVHMEVVHSLSTNSC-----IMAFRRF-VARR-GAPLEVYSDNGTCFVGA NRRLK-K-E------IHE-INE-K----------------------CA---ATFTNARTS ----WIFNPPAAPHMGGLWERMVRSVKTAMQAIGD--G---L-RHP----NEETF----- --ETI-----VLEAEAIVNSRP--------LTY------------I-------------- ----------------------GL-------------DSGDQEALTPNHF---------- ----------- >786/1-553 ----TKRMIYAGVAKFYDPLGLFSPAIVLAKLQSQH-LWKI-K----------A------ -DWDD-P-LEG--EVARHWQDLQASLAKLN---Q-IQVP--RRV--T------------- --AN-N-AV--AY-ELHG-FADASNV-AYG-ACVYLR--SIFA-DG------SAKM-S-- LLTS---------------------------KSKL-APL-------K------------- ---E----------------------------LSIPRKECCGAL-LLT-RLVKKVITE-- -L-N----M-E-F---QDV---VL---------WC------------------------- ---------------------------------------LPHHAV-------LRPS-SSS TKC-RVVFDASARTTPNN---LALNDVLLVGPVVQ--SELYAIMLRFR---IHKV--AFT ADISKMYRQILMAPE--HRHYQR-----I------FWREQ---T-TQ---------PL-R VLELDTVTYGTASAPYQATRC-LAQL------------A----EEE-KDEF--P-IAARI V-KQE--VYMDDM-LSGAE-T---VLEAIEAQQQLK-QL-LAHG-------GFPVH-KWC SNSV-EF-LKHMPVEERETQV------PLE---------------------------ESG ANKVI-----------------KV--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------VP SPPFAATGVDYAGPFW-------------------------------------------- ----------------------------VK--QGSRRP---TLV------KA-YLA---V -FVCMA--TKAVHLELVSDLSTDAF-----VAALRRM-ISRR-GCVQELHSDNATNFKGA HHELH-E-------LHKQFRDQ-LA------------------VQRIV---QFCQEREIE ----WHFIPPDAPEFGGLWEAAVKSAKTHLKRIVG--N-----AKL----TYEEF----- --STV-----LTEIEAVLNSRP--------MFA------------V-------------- ----------------------SN--------DPA--D-------P-------------- ----------- >787/1-569 ---WTKRKVFSAIAQLYDPLGIISPVVAWAKIHMQH-LWLI-S----------V------ -DWDD-L-IPE--EISIKWQEFYEQLSILQ---S-FKVP--RHV--F------------- --VL-N-PV--EI-QFHI-FCDASEV-GYG-TCIYSR--SISK-DG------QIMP-E-- LISS---------------------------KSRV-APL-------K------------- ---R----------------------------VSLPRLELCAAL-LAA-KLYSRVSAA-- -L-G----M-E-G---IRC---WF---------WS------------------------- -------------------------------------CYLPHHPV-------FKES-SST TKL-RVVFDGSAKTS-TN---HSLNDALLTGPVIQ--DDLLDLMVRFR---KHPI--ALV ADVEKMYRQIRIHPE--DTPLQR-----I------IWRFD---P-SE---------PF-Q VYELQTVTYGLSPSSFLATRV-LQKL------------A----EDN-AQRY--E-LAAAR V-SNG--FYMDDF-ISGAE-S---VEQARKLQEDVQ-TL-MAEG-------GLQLR-KWN SNRP-EV-LDGLPDDLNGNSL--A-L-HLEYE-----------------------SSS-- -ERTI-----------------KT--LG-------------------------------- -----VSWETESDQLGIEI----------------------------------------- ----------------------------------------------------------AP SRPFTITGVDYCGPVY-------------------------------------------- ----------------------------MKPV--HRRV---APQ------KA-FIA---V -FICFA--TKAVHLEIVCDLSTEAF-----IAALRRF-IARR-GLPTEMHSDNGTNFQGA KNALV-N-------LHTLLNDT-NH------------------QQKVI---DECSKNGIK ----WTFIPPRAPNFGGLWEAAVKTAKTSLSKTIG--N-----AKL----SYEDY----- --ATV-----LAQVEANMNTRP--------LTP------------L-------------- ----------------------SD--------DPD--E-------L-------------- ----------- >79/1-575 ---HTKRSLLSTVARLYDPLGFITPCVMTAKAILKD-SWMA-RIKRNDGSLAQL------ -DWDE-P-LPT--ELLDRWQGFIQNLPYVE---Q-IQVP--RWL---------------- ---RFNIHELASL-QLHV-FCDGSSL-AYA-ACAYIR--AELP-NG------MIQT-H-- LLAA---------------------------RSRV-TPT--K-P---------------- --------------------------------ITIPRVELSGAL-LAV-KLAKWIRDQ-- -L------R-TAGPP-MST---FY---------WS------------------------- -----------------------------------TCCTLPHHAV-------FKEE-SVT TKV-RVVYDASCKTS-NG---KSLNDVLCTGPALQ--NDLAGVVLNWR---FHRF--VFA ADIQKMYRCIDMNAE--DSQYQR-----I------FWH-D---E-HN---------QV-A EYYLNTVTFGTASAPYTAIRV-IHQL------------A----QDE-RDRY--P-LAERV L-RHE--IYVDDV-QSGAS-T---REGALEIQNQLI-GA-LRSA-------GMELR-KWS ANDA-SL-LQDIPPDHLSHKT----LLEFE------------------------------ YQDPV-----------------KT--LG-------------------------------- -----LYWHPHQDYFGFK---I-------------------------------------- ----------------------------------------------------------PP TRAFIATGVDYTGAFE-------------------------------------------- ----------------------------IQAS--RFRG---HTNY-----KA-YIA---V -FICLA--TKAIHLEAVTGLTTEHF-----LMALQRF-IARR-GYCQHMYSDCGTNFIGA DRALQTW-------QIHLKREL-PT--------------------TVI---PALAARNVQ ----WHFNPPHSPNFGGLWEANVKSVKTHLYRAFS--G-----YKM----TYEQL----- --ATV-----LTQIEACLNSRP--------LCP------------L-------------- ----------------------SA------------------------------------ ----------- >790/1-557 ----TKRIALSQIARLFDPLGLLGPVVITAKIFMQA-LWTL-K----------D-GNDKI YSWDE-P-LPA--SMVQRWNNYMQELPLLN---N-LRID--RYI--L------------- --TP-S-PA--YI-QYHF-FSDASQH-AYG-ACCYIR--TADT-SG------AFRV-T-- LLTA---------------------------RSRV-APL-------K------------- ---Q----------------------------QSIPRLELCGAL-LAS-QLYERVSQA-- -L-E----L-R-----GSS---FF---------WV------------------------- -----------------------------------PCYHMPHHAV-------VKND-STT TKV-RVVFDASCKSP-QG---PSLNDALMVGPTVQ--QDIRSIIMRSR---SRRV--MLI ADAKQMYRQVLVDER--DTPLQR-----I------VWRQS---P-EH---------PL-N TYELLTVTYGTASAPFLATRV-LSQL------------A----NDE-QNTF--P-EAAEI L-RKD--VYVDDL-LSGAN-S---IEDATKLRNQLD-AL-LSKG-------GFQLR-KWA SNEE-AV-LEGIPADNRALQE--S-F-DLD---------------------------R-- -SQSI-----------------KS--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA ARPFSVAGVDYWGPIT-------------------------------------------- ----------------------------LQRI--HRRA---APR------KA-YIA---V -FVCFV--TRAVHLELVIDLSTAKF-----LQALRRF-VSRR-GLCSDIYSDNGRNFIGA SNELR-K-------L---IRSK-EH------------------QQAVA---EECTANSIR ----WHFNPPKASHFGGLWEAAIHSAQKHFFRVLG--T-----HTL----AQDDM----- --ETL-----LAQIECCLNSRP--------LIA------------L-------------- ----------------------SD--------DPT--D-------F-------------- ----------- >791/1-527 ---PTKRQILRCVMSLFDPLGLLAPYLVFGKVLIQE-VWRI-G----------I------ -NWDE-K-VDD--KLFEQWRQWISMITTIN---N-VRIS--RSY--F------------- -RKAGVE-AFQSI-QLHT-FTDAGRD-ACA-CVSYLR--IVNN-EG------EIEV-A-- LVTA---------------------------KTKV-VPL--K-P---------------- --------------------------------VTIPRLELQACV-LGA-RLAKYIVEG-- -H------S-FVI---TKR---FF---------WS------------------------- ---------------N---------------VDIRRTWYLPLGAV-------TNPN-K-P GKV-RLIWDASAK-V-DG---ISLNSLLLKGPDYV--TPLCFVMFRFR---QHSV--AVS ADLKEMFHQVRIREE--DRSAQS-----F------LFRND---P-MA---------E-PQ IFRMDVATFGATCSPAIAQHV-KNVN------------A----KAY-EEEH--P-RAVEG I-VFN--HYVDDY-LDSFA-N---EEEAKQVAGQVR-DI-HRHG-------GFELR-IWC SNNV-EV-LQHL--GE-----NV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFSYVGLDYFGPLL-------------------------------------------- ----------------------------VK--VG-R-----S-HS-----KR-WIA---L -FTCMT--VRAVHLEVAHNMSTESC-----IACVRRF-LCRR-GFPVEIHSDNGTNFQGA ERLLR-E-Q----------INS-G----------------------LA---ETFTSTTTA ----WHFIPPATPHMGGAWERLVRSVKTALTAA-Y--N---N-DKL----DDEAL----- --QTM-----IAEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >793/1-556 ----TKRIALSQIARLFDPLGLLGPVVISAKIFMQA-LWTL-T----------D-DNGKP WSWDE-E-LPL--QLKERWYTYMSDLPRLN---S-LRIN--RFV--L------------- --TV-E-PA--YI-QYHF-FSDASQQ-AYG-ACCYIR--TADV-SG------KFKV-A-- LLTA---------------------------KSRV-APL-------K------------- ---Q----------------------------QSIPRLELCGAL-LAA-ELYLKVSQS-- -L-E----L-S-----GAV---FF---------WV------------------------- ------------------------------------CYHMPHHAV-------IREE-STT TKL-RVVFDASCKTA-EG---PSLNDALMVGPTVQ--QDIRSIIMRSR---THRV--MII ADAKQMYRQVLVDER--DTPLQR-----I------VWRQS---P-DQ---------PL-N TYELQTVTYGTASAPFLATRV-LLQL------------A----NDE-QQHF--P-EAAKV L-RND--FYVDDL-FSGAR-S---VKEAIQLRHQLE-AL-LSKG-------GFQLR-KWA SNEE-AV-LEDLATENRALQT--S-V-DLD---------------------------R-- -NQTI-----------------KS--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA SRPFSVTGIDYWGPIT-------------------------------------------- ----------------------------IKPV--HRRA---SPG------KA-YVA---V -FVCFS--TRAVHLELVIDLSTAKF-----LQALRRF-VSRR-GLCSDLYSDNGRNFLGA ANELR-S-------L---VDSN-TH------------------QQSIA---QECAKNGIR ----WHFNPPKGSHFGGLWEAAIRSAQKHFIRVLG--N-----NTL----AADDM----- --ETL-----LTQIECCLNSRP--------IIP------------L-------------- ----------------------SD--------DPS--D-------C-------------- ----------- >795/1-531 ----TKRIVVSEMSKLFDPLGILGPVIIKAKIFVQQ-LWKA-N----------L------ -DWDD-P-LPR--TLSADWEDYRLGLAALG---S-LSVP--RLV--K------------- --ALGA-GA--SM-QLHG-FCDASQH-AYG-ACIYIR--SVGT-NG------VIAT-R-- LLTA---------------------------KSRV-APL--Q-T---------------- --------------------------------LSIPRLELCSAV-LLS-KLFQAVAAS-- -L-N----I---T---TNA---YF---------WS------------------------- -------------------------------------FYLPHHAV-------IKPS-STT TKC-RVVFDGSSKSS-TG---ISLNDGLMVGPTVQ--DTLYSIVLRFR---LNEI--AVV ADITKMYRQIWVHPD--DRHFQR-----I------FWKGE---T-DF---------EV-Q PFELTTVTYGTASAPYLATRC-LQQL------------S----YDHSERED--D-IPAK- I-GKD--FYVDDF-LSGSD-S---VDDAVQLCSGVQ-HI-LGSA-------GFELR-KWS SNSP-EV-LAHIP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP ARAFLNTGVDYCGPVW-------------------------------------------- ----------------------------LKVP--VRRTKPVPPI------RA-YVA---V -FICMV--TKAVHLELVSDLSTDAF-----IAALKRF-VARR-GKPTTLYCDNATNFKGA DRELR-D-------LCKQLNNQ-QH------------------QQKVA---SFCAESAIQ ----FKFIPANAPTFGGLWEAAVKSMKHHFRRVVG--M-----EAL----SSEAM----- --ITV-----LCEIESCLNSRP--------LTA------------I-------------- ----------------------SE--------DPS--D-------L-------------- ----------- >798/1-582 ----TKRCVLSVIATLFDPLGLLGAAITSAKIFMQL-LWTL-H----------D-GENRR LGWDQ-P-LPS--TVGESWKRLYEQLPLLN---Q-IRID--RCV--I------------- --IP-K-VV--SL-ELHC-FSDASEK-AYG-ACLYAR--SLNA-AG------EVKI-R-- LLTS---------------------------RSKV-APL-------K------------- ---C----------------------------QTIPRLELCGAV-LAA-LLFEKVKHS-- -I-R----F-T-----GKS---FF---------WT------------------------- ------------------------------ETEAVKRCYLPHHPV-------IKEA-STT TKV-RVVFDASCKTA-TG---VSLNDVLLAGPTVQ--EDLRSIILRSR---TKQI--MLV SDVEKMFRQIYVDPK--DRPLQC-----I------LWRFS---P-SD---------VA-H TYELNTVTYGTKPAPYLATKT-LQQL------------A----LDE-EKTF--P-LAAKA V-IDD--TYMDDV-ITGAD-E---VETAIEMQRQLS-AM-SSGG-------GFRLR-KWA SNCP-TV-LEGVPEEDRAIRTPEG-I-ELD---------------------------P-- -DPSI-----------------KT--LG-------------------------------- -----LTWMPGTDTLRFQFT--IPTL---------------------------------- ----------------------------------------------------------TV SRPFLRTGVDYFGPLY-------------------------------------------- ----------------------------VRPG--PRRP---V-V------KA-YVA---I -FICMT--TKAVHMELVSDLSTDRF-----LQALRRF-ISRR-GRCTDIFSDNGTNFVGA RNKLQ-E-------LLRILKDS-SH------------------HETVS---SELAKEGIQ ----WHFNPPSAPHFGGLWEAAVRSAKNHLIKVLG--E-----TPA----TPEDL----- --CTL-----LVQVEACLNSRP--------LTP------------L-------------- ----------------------SN--------DPN--D-------L-------------- ----------- >80/1-558 ---PTKRQMLKCLMSLFDPLGLLSLFVVHGKILLQE-VWRE-G----------I------ -QWDE-K-VSE--ELHQRWKNWIRLFEEVR---S-LKIP--RCY--F------------- -SGATKQ-RYQDL-QLHI-FVDASES-AYC-AIGYFR--TSNA-DG------ITEC-A-- LVAA---------------------------KTKV-APL--K-T---------------- --------------------------------QSIPRLELLAAV-LGA-RLSQFIEEN-- -H------T-VRI---TRK---VF---------WS------------------------- ---------------N---------------ADMRRVWYLPLGAI-------TNPR-K-P GKV-RMIWDARAA-V-NG---ISLNSVLLKGPDQL--TSLPGVLVRFR---QFKV--GVS SDIKEMFHQILIRKE--DRHSQR-----F------LWRDD---P-SD---------T-PD VYLMDVATFGSTCSPASAQYI-KNRN------------A----KEF-QGLY--P-RAAEG I-VDN--HYVDDS-LESYE-S---AEEAIKVSQEMR-FI-HKEG-------GFELR-NWL SNSR-DV-LNAL--GEG----DPGE-DKRFAA-----------------------D-KQN DY--E-----------------RV--LG-------------------------------- -----LLWLTQED----------------------------------------------- ----------------------------------------------------------SF VRPFTYTGLDFFGPLM-------------------------------------------- ----------------------------VK--IG-R-----S-SA-----KR-WIA---V -FTCLT--IRAVHVEVAHSLTTDSC-----VKCIRRF-ICRR-GAPAEIYSDNGTNFLGA ARLLK-E-Q-----------EE-Q----------------------LA---VTFTGTATK ----WVFNPPGTPHMGGAWERMVRSIKTAVETAYN--N---N-RKL----DDEAL----- --ETF-----MVEAEAIVNCRP--------LTY------------L-------------- ----------------------PL----------TSEES--------------------- ----------- >801/1-536 ---PTKRIILQCVMSFYDPVG------------------GS-G----------T------ -DWDE-P-VTD--AIFNRWLSWTRILPAIE---T-VKVQ--RCF--F------------- -GDESIN-NITSV-QLHI-FSDAGDD-AYG-CVAYLR--YRV--AG------EVRC-T-- LVGS---------------------------KAKV-APL--K-L---------------- --------------------------------TSTPRLELQAAV-IGA-RMMTTLLAS-- -L------P-VSI---QEQ---FL---------WV------------------------- -------------------------------------WFLPLNVV-------VNPK-K-P GKI-RLTLDAAAK-A-GG---TSLNDMLLKGPDIL--VSLLDIINHFR---GRRI--GFG GDVKEMFLQIRMRQP--DTRFQK-----F------LFRQD---P-SK---------N-PD VYVMDVVIFGAKCSPCNAHFA-KDTN------------A----REH-ASRF--P-ATADA I-INR--HYVDDY-FDSAD-S---EDEAIQRAREVR-EV-HSLG-------GFEIR-NWV SNVP-KV-LEAL--GE------EGKPMKTLCY-----------------------D-KTL ES--E-----------------RV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TA SRPFTVTGIDYWGPIT-------------------------------------------- ----------------------------LQPP--NRRA---APR------KAYYVA---V -FVCFS--TRAVHLELVIDLSTAKF-----VQALRRF-VSRR-GLCREIYSDNGRNFIGA ANELR-Q-------L---VRSK-QH------------------VQSVA---RECADNGIE ----WHFNPPKASHFGGLWEAAIRSAQKHFVRVLG--T-----HTL----AQDDM----- --ETL-----LIQIECCLNSRP--------LVP------------L-------------- ----------------------SD--------DSS--D-------F-------------- ----------- >804/1-568 ----TKQIVLSDTARIFDPLGLIGPVVVQAKIFLQS-LWIE-G----------C------ -DWDD-P-LPE--KPQEFWLEFRRNTIALK---S-LEIP--RWT--C------------- --YTPS-LS--SV-ELHG-FCDASQA-AYG-ACLYLR--SVST-AG------LITV-R-- LITS---------------------------KSRV-APL--E-DLKR------------- ---KKRK-------------------------QNIPRLELSSAV-LLS-HLYEKFTDS-- -I-E----T---P---LNA---HF---------WT------------------------- ------------------------------EENEVPAYYLPHHAV-------LKPE-STT TKL-RVVFDASCRTS-TG---ISLNDGLMVGPVVQ--DDLLSIILRFR---FYRF--VVV ADIAKMYRMVNVCPN--DQPLQR-----I------LWRNS---T-NE---------PV-K AYQLTTVTYGTSSAPYLATRC-LQQL------------A----TDG-EETH--K-RAAPA V-RKG--FYVDDL-LTGAD-T---EEEGKALVAEML-DL-TNSA-------GFTLR-KWS SNSV-EF-LSRIPVDLRDDRV--T-L-ELD---------------------------S-- SSTPV-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------SP SAVFCKVGVDLCGPFY-------------------------------------------- ----------------------------IKYP--IRRS---PAV------KS-YVA---I -FVCLI--TKAVHMEIVADLSTQAF-----LSAFRRF-VATR-GKPQVVKCDNATNFVGA NRELE-D-------LRRQFLDQ-QF------------------QHTIV---RSAEDEGIQ ----FAFIPARSPNFGGLWEAAVKSFKGHFRRSIG--T-----RQL----SYDEL----- --NTI-----VQQVAAVLNSRP--------LTP------------L-------------- ----------------------SS--------DPN--D-------F-------------- ----------- >805/1-583 ---FTKRTILSVVATLFDPLGLLGAVIVSAKILLQK-LWSI-R----------D-KNDQP LGWDD-P-VPP--TVGEEWRNFYEQLPLLN---E-LRIE--RCV--I------------- --IP-N-VV--AV-EIHC-FSDASEK-AYG-ACLYVR--STDA-EG------NVKV-R-- LLSS---------------------------KSRV-APL-------K------------- ---C----------------------------KPIPRLELCGAV-LAA-ELFEKVRDS-- -I-K----M-N-----ANF---FF---------WT------------------------- ------------------------------AESATRRVYLPHHPV-------VKEA-STT TKV-RVVFDASCKTS-SG---SSLNDVLLAGPVVQ--EDLRSIILRSR---TKQI--MLV SDVEKMFRQIFIRQE--DRPFQC-----I------LWRNS---P-TE---------IL-R SYELNTVTYGTKPAPFLATRT-LQQL------------A----LDD-EAKF--L-LAARA A-IED--TYMDDV-ITGAD-D---EEIATALQVQLN-TM-MSGG-------GFQLR-KWA SNCP-SV-LAGIPQENLAIRTLDE-I-NLD---------------------------P-- -DPSV-----------------KT--LG-------------------------------- -----LTWTPSTDVLRFQFT--ILPL---------------------------------- ----------------------------------------------------------TK SRAFYVTGVDYFGPVY-------------------------------------------- ----------------------------LRPV--PRRA---A-V------KA-YVA---I -FICLA--TKAVHLELVSDLSTDRF-----LQALRRF-VARR-GRCASIYSDNGTNFVGA RNKLQ-D-------FLKLLKSR-DH------------------HDAIS---KECAKDGIQ ----WHFIPPSAPHFGGLWEAAVRSSKHHLLRVVG--E-----SPV----HPEDF----- --NTL-----LTQVEACLNSRP--------LTP------------L-------------- ----------------------SG--------DPN--D-------L-------------- ----------- >806/1-517 ---PSKRELLSLVMSVFDPLGIVAPFVVHGKVLVQE-VWKS-G----------V------ -GWDE-Q-LPA--DIIPQWKKWVNLFGTLE---T-VRVP--RCY--F------------- -PGYSPN-TYESL-ELHV-FVDASSA-AYA-AAAYFR--VDD--GG------TIRC-S-- LVSA---------------------------KTKV-API--K-L---------------- --------------------------------LSIPRLELQAAV-IGT-RLRKTIISD-- -H------T-LSI---KRT---IM---------WS------------------------- -------------------------------------WFLPLGVV-------ENPK-K-P AKV-RIIWDAAAS-V-RN---ISLNSVLLKGPDLL--TSLQSVLCRYR---QREV--AIN GDIMEMFHQVEIRPQ--DRPAQR-----F------LWRNQ---P-TE---------P-IQ VFEMNVATFGSTCSPSSTQYV-KNLN------------A----AEH-AEEF--P-KAARA I-TEN--HYVDDY-LDSVE-T---VEEAVQLAMEVK-EV-HERA-------GFLIR-HWM SNST-EV-LQQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PY VRAFTFTGLDYFGPLN-------------------------------------------- ----------------------------VR--FG-R-----G-CI-----KR-WVA---L -FTCLG--TRAVHLELAYSLSTESC-----KTAIRRF-VARR-GAPKEIYSDRGTNFQGA SAELR-Q-Q------IKA-INE-E----------------------LA---EVFTNAETQ ----WRFNPPYAPHMGGVWERLVRSVKQGLEQ-MQ--L---P-KNP----DEETL----- --VTA-----LAEVESIVNSRP--------LTY------------L-------------- ----------------------PI-------------DS--------------------- ----------- >807/1-536 ---WTKRKIFSAIAKLYDPLGLVSPVVAWAKIRMQH-LWLA-T----------V------ -DWDD-P-VPQ--DVSEKWEEFTTQLPLLQ---N-YKVP--RFI--F------------- --LP-S-PT--TV-QFHV-FTDASEV-GFG-ACIYAR--STNG-D-------HVKI-E-- LIAA---------------------------KSRV-APL-------K------------- ---R----------------------------LSLPRLELCAAL-LGA-KLYAKVSAA-- -L-R----M-E-G---VPS---WF---------WS------------------------- -------------------------------------CYLPHHPV-------FKES-SST TKI-RVVFDGSAKTS-TN---YSLNEALLTGPTVQ--EELLDLMLRFR---KHAV--ALV ADVAKMYRQILVHED--DKPLQR-----I------LWRFY---E-SK---------SI-Q VYELQTVTYGLSPSSFLATRV-LKQL------------A----LDS-DQRY--K-PAVSA V-LED--FYMDDF-LSGAD-S---MEKAIVLQQEVQ-AL-LADG-------GLQLR-KWR SNHP-EV-LHHLPTEVLGVEK--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VS NRAFTVVGVDYCGPVY-------------------------------------------- ----------------------------TKPA--HRRA---APR------KA-FIA---V -FVCFA--SKAVHLELVGDLSTEAF-----LAALRRF-IGHH-GMPAEIHSDNGTNFQGA SNMLT-E-------LYRLFETN-QT------------------REAII---NECSKHRIQ ----WKFIPPRAPSFGGLWEAAVKTAKTSLMRTLG--K-----CQL----SFEDY----- --ATI-----LTQIEANMNSRP--------LTS------------L-------------- ----------------------SG--------DPM--E-------L-------------- ----------- >809/1-518 ---PTKREMLRVLMTIFDPLGLIAHFLIFLKILLQE-VWRS-K----------V------ -QWDE-E-VSG--DVYRKWQLWTSVLPQVE---N-VRLP--RCY--S------------- -SPLAVS-SCTDI-QLHT-FVDASEN-GFA-AIAFLR--FDY--NG------STQC-S-- IVAS---------------------------KARV-APL--K-F---------------- --------------------------------LSIPRLELQGAV-LGA-RLAQTIISS-- -L------T-LRI---TRR---VY---------WT------------------------- -----------------------------------RTWYLPIFPV-------TNPN-K-P GKI-RLVWDAAAK-S-FN---VSLNSALLKGPDLL--CSLLAILLQFR---QGRI--GLS GDIREMFHQILMRTE--DQHCHR-----F------FWTDE---N-GE---------L--A VYVLQVMSFGASCSPSCAQYV-KNVN------------A----ERF-RATH--P-IAVEA I-TKR--HYVDDM-LVSVD-E---ENQAIRLAEEVK-YV-HSQG-------GFEIR-NWM CNSR-TV-LTA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF TRPFTYVGVDYFGPLE-------------------------------------------- ----------------------------VV--VG-R-----R-TE-----KR-WGM---L -ITCLT--VRAIHIELVCSLSTNSC-----IMGLRNF-ISRR-GTPRRIYSDRGTNFIGA NRELS-E-------AVAAINQP-V----------------------MA----EFVSPDTE ----WIFNPPAAPHMGGCWERLIRTVKTNLMAIRP------A-SKL----TDEEL----- --RNT-----LTEIENIVNARP--------LTH------------V-------------- ----------------------PI-------------DN--------------------- ----------- >81/1-593 ---PTKRSILSAVSKHFDPLGLTAPIVIKAKMLLQE-LWLQ-P----------C------ -GWDE-E-ISD--TMRTKWDSYRTELPKIV---S-YRTD--RFA--F------------- --LP-N-AS---V-QLHT-FADASQQ-AYG-ACIYAR--STDS-HG------KTKI-Q-- LIAA---------------------------KSKV-APL-------K------------- ---R----------------------------ISLPRLELSAAV-IAA-RLHQKVVVA-- -L-D----M-T-I---SAS---FF---------WS------------------------- -------------------------------------HYLPHHAV-------LKEA-STT TKV-RVVFDGSAKTS-TG---YSLNDALQVGPIVQ--DELLTLIIRFR---KYPI--ALV ADIAKMYRQVLLHPD--DAPLQR-----I------LWRFH---P-ND---------PI-E TYELATVTYGLAPSSFLATRT-LQQL------------A----ADE-GHAY--P-RGGPA L-KKG--FYVDDY-IGGAN-T---EEEAIQTREELD-EL-LAKG-------GFQLR-KWT SNNP-KV-LEGLDPSQIGTQP--T-L-KLD---------------------------N-- -NEST-----------------KA--LG-------------------------------- -----VSWEPGTDQLRFDSAPELGNGPPTKRSILSAVSKHFDPLGLTA------------ ----------------------------------------------------------TP SRPFSITGIDYAGPVY-------------------------------------------- ----------------------------IRAI--HKRA---SPT------KA-YIS---V -FVCFV--TKAVHLELVSDLSTPAF-----ITALRRF-IARR-GCPAHIHSDNGKNFEGA RNELR-E-------LYQLLQEE-ES------------------SGNVA---TFCANQGIQ ----WHMTPPKAPHFGGLWEAAVKVAKRHLHRQFG--D-----SRL----SFEEM----- --STA-----LAEIESAMNSRP--------LTP------------L-------------- ----------------------TE--------DPN--D-------L-------------- ----------- >813/1-543 ---PTKRSILSDIARLFDPLGLIAPIVMKAKIIMQE-LWTL-A----------C------ -DWDD-P-VPN--TIRVKWEQFRHELPKIA---V-YRID--RYA--L------------- --LP-K-SS---V-QLHT-FADASTF-AYG-ACTYVR--CEDS-RG------TVKI-R-- LLAS---------------------------KSKV-APL-------K------------- ---R----------------------------LSIARLELCACV-LAA-HLHHRVKES-- -I-G----V-H-V---TAS---YF---------WS------------------------- ------------------------------------------------------EE-STT TKV-RVVFDGSARTS-TG---FSLNEALCVGPVVQ--EDLLSIVLRFL---TYPV--ALV GDIAKMYRQVLLHPD--DCSLQR-----I------LFRFD---R-NT---------PI-Q TYELRTVTYGLAPSSFLATRT-LQQL------------A----VDE-GDKY--P-LAGPT I-CKS--FYVDDY-IGGAD-S---IEEAIQLRGELS-EL-LTKG-------GFELR-KWT SNRL-EV-LQGLKNDQIGTQS--S-L-QFS---------------------------P-- -NETI-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------VQ SRPFSVTGVDYAGPLY-------------------------------------------- ----------------------------LKPI--HKRA---ASA------KA-YLA---V -FVCFA--TKAVHLELVGDLSTQGF-----LAALRRF-ISRR-GMPNHIHSDNGKNFEGE KGELA-E-------LFERFNSD-KE------------------QAEIA---SACALKGIT ----WHLTPPKAPHFGGLWEAAVKTAKKHLFRQLG--N-----TRL----SFEGY----- --YTI-----LAQIEAAMNSRP--------LLP------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >814/1-563 ---ATKRTIYSEVAKFFDPLGLFSPVIVVAKLLVQH-LWKT-K----------Q------ -GWDE-P-VEK--ECQQKWNELQQALPQLA---L-IHVP--RRV--T------------- --SD-D-AV--FF-ELHG-FADASTV-AYG-ACCYVR--SVFS-DG------SAKL-V-- LLAS---------------------------KSKV-APL-------H------------- ---D----------------------------LSIPRKELCAAL-LLT-RLLQKVIPA-- -M-Q----M-E-F---REV---SL---------WS------------------------- ------------------------------DPKDKQSYYVPHHAV-------LRPT-SSS TKC-RVVFNASAKPSPSA---LSLNAVLHVGPVVQ--SDLFTIAIRFR---KYKF--VFS ADITKMYRQVWLVQD--DTCYLR-----I------FWREN---P-SL---------PL-R VLELNTVTYGTASAPFQATRC-LNQL------------A----DED-SRIP--P-DVVRI I-KEE--FYVDDV-LSGAN-T---IEKAVECYEQLK-SS-LAQG-------GFPLT-KWC SNSE-EF-LQHIPEEDQEKQQ------AIP---------------------------VYE ANELI-----------------KL--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------NP SPPFAVTGIDYAGPIW-------------------------------------------- ----------------------------IK--EGKYRP---KIV------KA-YIA---V -YVCMA--TKAIHLEAVTDLSTNAF-----LASLKRF-VSRR-GLVQRLYSDNATNFRCA HHEMN-E-------LFKQFQDQ-KA------------------IDDIH---QFCQTREIE ----WHFIPPDAPEFGGLWESAVKSAKTHLKKIVG--N-----SKL----TFEEL----- --ATV-----LAEIEAVLNSRP--------LFA------------I-------------- ----------------------SN--------DPA--D-------S-------------- ----------- >819/1-559 ----TKRKVISYIAKIFDPLGLVGPAIATAKLFMQR-LWKL-K----------N-EDKSP YEWDR-P-LPD--KLQDEWKQFHATLPILA---E-IKIS--RFV--S------------- --LP-D-VS--KT-ELHF-FSDASEV-AYG-ACCYVR--TLN--AE------EMKV-Q-- LLTS---------------------------KSKV-APL-------A------------- ---TK---------------------------HTIARLELCAAV-LST-KLYHKVQQS-- -I-K----T-P-----AEV---FF---------WT------------------------- -------------------------------------CYLPHHPV-------FKES-STT TKV-RVVFDASCKTS-SG---MSLNDTLLVGPVVQ--QNLDSIIIRFR---FHAV--AIV ADVEKMYRQILHSPD--DQRFLR-----V------LFRQR---P-LD---------PL-D TYELLTVTYGTASAPFLATRT-LQQL------------A----KDE-GHNY--P-EAEEA V-VED--FYVDDV-LTGAN-N---LESALEKRRQLS-AM-LASA-------GFPLK-KWA SNVP-EA-LSDIPPEDLAIKP--L-H-DLQ---------------------------D-- -DQSV-----------------ST--LG-------------------------------- -----LVW---------------------------------------------------- ----------------------------------------------------------TP ARPFAISGVDYCGPVF-------------------------------------------- ----------------------------IKSP--IRNR---APT------KA-YIG---I -FVCFA--TRAVHIELITDLSTPAF-----LSALRRF-VARR-GLVREIHSDNGTAFKGA ANTLH-R-------IYEMLKSS-DAD-----------------RNQIQ---TWCAERQIQ ----WKFIPPRAPHFGGLWEAAVKSAKHHLLREIG--N-----ISL----PYEDM----- --ITL-----LAQIEMCLNSRP--------LTP------------I-------------- ----------------------PS--------DPA--D-------L-------------- ----------- >82/1-537 ---PTKREIARVVMSLFDPLGFIAFFLVHGKILLQD-IWAK-G----------T------ -EWDQ-Q-IPE--DINERWQQWSKLFNQLS---Q-IRIP--RCY--F------------- -RSPFPA-SLDGL-QVHL-FVDASES-AYA-CAVYFR--LET--DG------DTQV-A-- LVGA---------------------------KTKV-APL--K-T---------------- --------------------------------LSIPRLELKAAV-LGV-RLLDTIQSQ-- -H------E-FPI---SRR---FC---------WS------------------------- ---------------S-----------------PADVWYLPLGVV-------TNPR-K-P GKV-RLIWDAAAK-V-NN---TSFNCKLLKGPDLL--APLPQVLRQFR---QFPV--AVC GDIMEMFHQIKIRTP--DNQSQR-----F------LFRDD---P-SD---------P-PR VYVMDVATFGSTCSPASAQYI-KNLN------------A----EEF-SNEY--P-RAAAA I-KNK--HYVDDY-LDSFK-T---VQEAIEVVNEVK-QV-HSMA-------GFTLR-HFL SNEA-DV-LRGI--GA-------------------------------------------- -----------------------S--CE-------------------------------- -----VKNLDLSF----------------------------------------------- ----------------------------------------------------------AF NQPFTFTGLDYFGPVL-------------------------------------------- ----------------------------VK--VG-R-----S-NV-----KR-WVA---L -FTCLT--TRAIHLELVHSLSTESC-----IMAVQRF-VSRR-GLPREFWTDNATCFQGT SNELK-T-L------NEA-TKK-A----------------------MA---EKFTTAQTA ----WKFIPPSTPHMGGAWERLVRSVKVAIGAIMD--G---P-RRP----DDETL----- --ETI-----LLEAEAMINSRP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >820/1-562 ----TKRLVLSEAARLFDPLGLLGPVVLRSKLFMQE-LWKS-K----------V------ -SWDI-P-LND--HQQQFWKSFRRDLEILD---T-FTVP--RWA--A------------- --PHLD-AA--NL-ELHG-FSDASES-AYG-ACIYIR--TISP-NG------IVSV-N-- LLTA---------------------------KSKV-APK--G-TEKL------------- ---DPS--------------------------IRLPRLELCGAL-LLS-HLFQKVESS-- -L-K----N---Q---VRP---FF---------WT------------------------- -----------------------------------KTYYMPHHCI-------VRPE-NVT TKL-RVVFDASCASD-TG---VSLNDALIVGPVVQ--DELYSIILRFR---MPRF--VIV ADLEKMYRQVLVSPA--DRPLQR-----I------VFRSS---P-SE---------PL-Q TYELLTVTYGTASAPYLATRC-LQQL------------A----SDG-ESTH--P-KTAKA L-SKD--FYIDDL-LGGVA-S---EEEGITLCRELI-DL-LSSA-------GFKLH-KWA SNSP-RI-LQNIPPELREDRS--L-L-ELD---------------------------S-- STSPV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TP TLPFLNTGVDFCGPFY-------------------------------------------- ----------------------------LRPP--TRRA---APL------KS-FVA---V -FVCLS--TKAIHLELVSNLSADSF-----IASLKRF-AARR-GVPQTIYCDNATNFVGA RRTLN-E-------FLHLFRTQ-QN------------------RLDVT---RRCSAEGIQ ----FSFIPPRSPHFGGIWEAAVKSLKTHLHRTLA--N-----ALV----STEQF----- --QTL-----ITQIEALLNSRP--------LTQ------------L-------------- ----------------------SN--------SPE--D-------L-------------- ----------- >83/1-516 ----TKRSILRFVMSVFDPLGLISNLLVHGKVIIQD-LWRA-Q----------V------ -GWDD-T-IPL--DILENWNRWIEQLTKLD---R-LRIP--RCY--F------------- -SGYNPD-SYQTL-QLHI-FVDASES-AFA-CVAYFR--IID--YG------QPRC-A-- LVAS---------------------------KAKV-APL--K-P---------------- --------------------------------LSIPRLELQAAV-IGS-RLAKSVAEY-- -H------K-LPV---SRR---VF---------WS------------------------- -------------------------------------WYLPLGVV-------TNPR-K-P GKV-RIVWDAAAK-S-NG---VSLNDVLLKGPDLL--TALPAVLCRFR---QREV--AIA GDIREMYHQLKIRKE--DRQVQR-----F------LYRSD---P-SQ---------K-PN VFVMDVAIFGATCSPCSANFV-KNTN------------A----TEW-KNEF--P-EAATA V-IEN--HYVDDY-LDSRD-T---EEDMAKLASDVR-KV-QAEA-------GFELR-NWR SNSK-MV-LQ-------------------------------------------------- ------------------------------------------------------------ -------S---------------------------------------------------- ----------------------------------------------------------PY VRPFSLVGIDYFGPYL-------------------------------------------- ----------------------------IK--IG-R-----S-QV-----KR-WVA---L -FTCLV--VRAVHLEVTTSLSTEAC-----KLALRRF-IARR-GAPTQIYTDHGTNFVGA SRELA-N-Q------LAE-MNK-E----------------------LS---ETFTDANTR ----WFFIPPSSPHMGGAWERMVRAVKTAMES-VN--H---S-RAP----SEEVF----- --QTI-----LCDAEAMVNSRP--------LTY------------V-------------- ----------------------PL-------------ET--------------------- ----------- >830/1-518 ---PTKREVLKVVMSLFDPLGFVSFFLVHGKVLMQD-IWAS-G----------I------ -NWDE-H-ISE--QIHVRWRQWITYFPRLD---T-LRIP--RCY--F------------- -SSPFPK-NFGRL-ELHV-FVDASDS-AYA-CVAYYR--LET--EN------GVQV-S-- LICS---------------------------KSKV-APL--K-V---------------- --------------------------------LSVPRLELKAAV-LGV-RIIESIEGY-- -H------T-YAI---SRR---FL---------WS------------------------- -------------------------------------WFLPLGVV-------VNPK-K-P GKI-RLIWDAAAK-V-DG---VSFNSYLLKGPDLL--TPLPRVLSGFR---LFPV--AVS GDIREMFLQIKLQKG--DRNTQM-----F------VFRHN---P-AE---------P-VQ IXAIEVTMFGSTCSPSSAQFV-KNVN------------A----EQY-ALHY--P-RAAAA I-KEH--HYVDDY-LDSFR-T---IEEAIQVVNDVK-LV-HAKG-------GFEIR-NFL SNEN-EV-LKQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PF VRPFTFVGVDYFGPIL-------------------------------------------- ----------------------------VK--VG-R-----S-CV-----KR-WVA---L -FTCLT--ARAVHLEVVHSLSTESC-----IMAVRRF-IARR-GFPAEFYSDNGTCFQGA SKELR-R-E------MEN-RNK-S----------------------LA---TAFTTAKTR ----WCFNPPSAPHMGGVWERLVRFVKVAIGTIAD--A---S-RKP----DDEVF----- --ETI-----LLEAEALINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >838/1-562 ----THRIVLSEIARLFYPYGLVGPVIVLGKLFLQD-LWRG-K----------Y------ -SWDE-P-LSG--ELQLQWLEFRTNLRELN---A-ISVP--RWI--N------------- --FRKD-VV--SC-EFHG-FSDASDK-AYG-AAIYLR--CVNQ-DG------QVTI-N-- LLMA---------------------------KSRI-APL--E-DLSK------------- ---RKKK-------------------------QNIPRLELSAAL-LLA-HLFESVSSS-- -M-M----I---A---AKS---FF---------WT------------------------- -----------------------------------PEYYVPHHAV-------IKPD-STT TKL-RVVFDASCSTD-TG---VSLNDVLMVGPVVQ--DDLRSILLRFR---LFKY--AVV GDAEKMYRMVWQHKS--DQQLHK-----I------FWRDS---I-DE---------PL-R AYKLTTVTYGTASAPYLATRC-LNKC------------A----EDG-AERY--P-LGSVV V-KKS--FYVDDM-LAGAD-T---VEESQQLCKEVL-EL-LKGS-------GFNLR-KWN SNNP-EV-LKEIPLHLRDDRV--K-L-DLD---------------------------E-- -KATV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------SP APAFQRVGIDYCGPFE-------------------------------------------- ----------------------------LQNA--RRKG---APL------KC-YIC---L -FVCMV--SKAVHIEVVMDLTADAF-----LAALRRF-VARR-GRPVQIFCDNATNFVGA RRQLS-E-------LNRMFRQQ-QF------------------QERLS---TEAARNSIT ----FNFIPAKSPNFGGLWEAAVKSLKGHMRKVIG--T-----RRL----SQDEM----- --QTV-----VIQIEACLNSRP--------LTP------------L-------------- ----------------------SN--------DPA--D-------L-------------- ----------- >84/1-567 ---PTKRQVLSVIASLFDPLGLLGAAITTAKIIMQL-LWRI-R----------N-EAGEA LDWDQ-T-LPQ--TVGELWRKYYEELHLFN---N-IRID--RCV--M------------- --IP-E-AV--LV-ELHC-FSDASNK-AFG-GCVYIR--SQDS-EG------NLQV-R-- LLSS---------------------------KSKV-APL-------K------------- ---T----------------------------QSIPRLELCGAL-LTA-QLYEKVRDS-- -I-R----V-P-----VEC---YF---------WT------------------------- ------------------------------TADNLKRCYLPHHPV-------IKEA-STT TKV-RVVFDASCKTS-SG---VSLNDALLVGPTVQ--EDLRSIMLRSR---VRQI--MLV ADVEKMFRQIFIQQT--DRPLQC-----I------LWRFN---P-LD---------KE-D VYELDTVTYGTKPAPFLATRT-LNQL------------A----IDE-GELF--P-AAAKA I-KED--TYMDDV-ITGAD-T---EEAAQELCEQLN-EM-TSKG-------GFKLR-KWV SNIP-MV-LKSVSEDGLAIKVSEG-I-DLD---------------------------P-- -DPTV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV SRPFSQTGVDYFGPFY-------------------------------------------- ----------------------------VRPA--PRRP---V-V------KA-YAS---V -FICLC--TKAVHLELVSDLSTDRF-----LQALQRF-TARR-GLCQDLYSDNGTNFVGA RNKMQ-D-------FLKLLKNS-DH------------------KEKVT---KDCTEQGIQ ----WHFNPPSAPHFGGLWEAAVRSAKGHLIKVVG--E-----TPL----SPEDF----- --NTL-----LIQVEGCLNSRP--------LTP------------L-------------- ----------------------SD--------DPT--D-------L-------------- ----------- >840/1-552 ---PTKRQVLRVVMSIFDPLGLVATFVVHGKRLIQD-IWRA-G----------V------ -GWDD-P-IPE--QLASQWRRWVEVLRHLN---Q-VKIP--RCY--F------------- -PGYEPR-SLDSL-ELHV-FVDASEA-AYA-CAAYFR--IVD--RG------QVRC-A-- LVSA---------------------------KTKV-APL--K-P---------------- --------------------------------MSVPRLELQAAV-IGV-RLIKSVQEN-- -H------T-LPI---SRR---MI---------WG------------------------- ---------------S---------------SDPRSVWYLPLGVV-------QNPN-K-P GKV-RVVWDAAAK-T-SG---VSLNSMLMKSPDLL--TSLPSVLFRFR---QREV--AIT GDIEEMFHQIMIRPE--VRQAQR-----F------FWRDN---P-ED---------Q-MQ EFVMDVATFGSTYSPCSAQYV-KNKN------------A----EEW-KQIY--P-KAAXA I-LDN--TYVDDY-ANSSD-T---VEEVVRVALEVK-EI-HASA-------GFVIR-NWL SSSE-QV-LRRV--GE-QSSE----SAKHFIV-----------------------E-KST DT--E-----------------RV--LG-------------------------------- -----MTW---------------------------------------------------- ----------------------------------------------------------PY VRPFTFIGIDYCGPFL-------------------------------------------- ----------------------------IR--IG-R-----S-NM-----KR-WVV---L -ITCLM--IRAVHLEVASTLTSESC-----KMALRRF-IARR-GATQEIYSDHGTNFVGA SRELR-E-E------VSA-VNR-D----------------------LA---ETFTNRDTQ ----WRFNPPAAPHMDGAWERLVRTVKSSLET-LS--V---T-RTP----DEEPF----- --QTL-----LVEVEGIVNSRP--------LTF------------V-------------- ----------------------PL-------------DT--------------------- ----------- >85/1-553 ---CTKRQILSDVARIFDPLGLLSPIVVQFKIMFQQ-LWLL-D----------L------ -GWDT-K-LPP--NIAEPWLKCRADLDTLK---K-LRVP--RFV--P------------- --NRED-----SI-ELHA-FSDASTK-AYA-AAVYCR--FRHE-DG------TYSV-S-- LVAA---------------------------KTRV-APL-------K------------- ---Q----------------------------QSLPRLELCGAL-LLS-RLVRSLKDG-- -L-R----H-K-D---IQV---YA---------WC------------------------- ------------------------------SFDSGNFFYLPHHPI-------V------G RKL-RIVFDGSFKDA-NG---VALNDVLHIGPSIQ--RNLFSVCLRFR---MYRY--VFS ADIVKMFRQIWVSPD--HQNYQR-----I------VWREH---P-SA---------PL-K HYQLDTVTYGTACAPYLAVRV-LEQL------------A----YDH-KEQY--P-TASKI L-LED--FYVDDV-LTGSN-N---ENELIAIRNELL-EL-MSHA-------KLELD-KWV SNSS-RI-CRRESSTE------REE----------------------------------- --EAV-----------------KV--LG-------------------------------- -----IYW---------------------------------------------------- ----------------------------------------------------------TQ SLPFVNSGCDYAGPIT-------------------------------------------- ----------------------------LKDR--KGRN---AKKS-----KG-YIC---L -FVCLV--TSALHLELATDLSTETF-----LAALRRF-MSLR-GKCAQIYSDNGRNFVGA RRALD-E-------MQQLLASS-QH------------------KDRVS---QTLADEGIK ----WVFIPPYAPHWGGKWESSVRSVKLHLRRVIG--N-----TIL----TFEQM----- --HTL-----LAQISAVVNSRP--------LYY------------T-------------- ----------------------PD--------TD-----------VTYLSPAHL------ ----------- >850/1-577 ----TKRKVLSIIATLFDPLGLLGAAITSAKIFMQQ-LWSV-Q----------D-EKGQK IDWDQ-P-LPS--TVGEVWLKFRSQLPTFN---Q-ITID--RCV--V------------- --IP-G-AV--SM-QIHC-FSDASEK-AFG-ACVFMR--SVNA-EG------SIMV-R-- LLTS---------------------------KSRV-ASL-------K------------- ---C----------------------------QSIPRLELCGAL-LAA-QLCEKVQAS-- -L-K----R-T-----MET---FF---------WT------------------------- ------------------------------TQESVQRCYLPHHPV-------VKEA-STT TKV-RVVFDASCKTA-SG---VSLNDVLLVGPVFQ--EDLRSIVLRCR---TRQI--MLV SDVEKMFRQIYVCKE--DRPLQC-----I------LWRSS---P-ID---------DV-E VYELNTVTYGTKPAPFLATRT-VKQL------------V----EDE-EQRY--P-LAAQA A-SED--VYMDDV-ITGAG-N---VETALNLRDQLD-QM-MSGG-------GFRLR-KWA SNCP-KV-LEGIPPEDLAIKQSSE-V-NLG---------------------------S-- -DPSV-----------------KT--LG-------------------------------- -----LTWVPKTDVLKFQF----------------------------------------- ----------------------------------------------------------TV SRPFSRTGVDYFGPVY-------------------------------------------- ----------------------------IRPA--PRRP---A-M------KA-YVA---L -FICLC--TKAVHLELVTDLSTERF-----LQALHRF-VARR-GKCSDIYSDNGTNFVGA RNKLQ-E-------FLKLLKDQ-TH------------------REIVA---KDCAMQGIQ ----WHFSPPSAPHFGGLWEAAVRSAKKHLLKVIG--E-----DPV----SPEDF----- --STL-----LVQVEGCLNSRP--------LTP------------M-------------- ----------------------SE--------DPE--D-------L-------------- ----------- >86/1-522 ----TKRNILKMAASFFDPLGFLTPITSRVKTIFQL-ICRD-K----------S------ -GWDE-I-VTE--AIELALTEFLKDLELLS---F-VRIP--RFV--F------------- -ER-VNE-SSKRV-QLHG-FCDSSKL-IYC-AVIYLV--VETS--L------GVNR-K-- FLVS---------------------------KSRV-SPL--K-E---------------- --------------------------------LSIPRLELLGCV-LLS-RLLEEVLRV-- -L------S-GRVHF-EDV---SC---------WC------------------------- --------------------------------------YLPHRPV-------IRK-DKDT TKI-RAVFDASCS---TT--GPSLNDCLYSGPNLL--SKIFDILLKFR---FNAI--GII ADIKQAFLNIEISPE--HRDYLR-----F------LWYER---I-SDKE------XKL-I VYRFLRVVFGLTSSPFLLNAT-LKHH------------L----NKYIKHDK--K-FI-ER L-IDD--LYVDDI-ASGCN-T---LXXILMXYKKSK--I-FLD--------GFELR-KWX YNXS-XI-TNYFNKKE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------NN LYSFQATGLDYAGPLF-------------------------------------------- ----------------------------VKTVNKD--A----AC------KV-YVL---L -LTCAS--SRAIHLELTPDMKIPAF-----IRAFKRF-AARR-GFPDLIISDNFKTFIS- --------------------------------------------KEVK---NFMMKNDVQ ----QKFILPASPWWGGFYERLVRSVKITMKKTIG--K-----SLL----SYEEL----- --ETI-----LCEIESVINSRP--------LFY------------F-------------- ----------------------SE--------DDT--E-------EA-LTPYHL------ ----------- >863/1-536 ---PTKREVLRVLMTIFDPLGLISHFLSYLKILLQQ-IWRS-G----------I------ -QWDE-E-VDD--DAYNKWLTWLKVLPRVE---Q-VKVP--RCY--N------------- -SKYLIS-EADEV-QLHT-MVDASEN-GTA-AVCYLR--FTH--DG------SVSC-S-- IVAA---------------------------KCRV-APL--K-F---------------- --------------------------------TSIPRLELEAAV-VGA-RLSHSVQES-- -L------T-FKI---LRK---LY---------WT------------------------- -----------------------------------RRWYLPVFPV-------TNPN-K-P GKV-RIVWDAAAS-A-HG---TSLNSALLKGPDLL--CSLLTILIQFR---ERRI--GLT GDIREMFHQVLIRAE--DQICQC-----F------YWMNQ---N-GE---------T--Q VYAMQVMTFGACCSPTTAQFV-KNTN------------A----DRF-ANDF--P-AAHQA I-TKS--HYVDDM-LVSLD-T---EEQAIQLAKDVR-HV-HQKA-------GFEIR-NWI SNSR-MV-LAAL--QG---AETD---EKCLDM-----------------------SSE-L ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AF SQPFTHVGVDYFGPIE-------------------------------------------- ----------------------------VT--VG-R-----R-VE-----KR-WVL---L -ATCLT--IRAIHLEVTHSLDTSSC-----IMALRNF-MARR-GTPQTVYSDRGTNFVGA NRELM-E-------INEVMNER-E----------------------FM---KEFGKTGIE ----WVFNPPLTPHMGGSWERLIRTVKNNLAVVCL------S-ARP----SDEVL----- --RNL-----LTEIENTVNSRP--------LSH------------V-------------- ----------------------PI-------------DD--------------------- ----------- >864/1-562 ----TKRLVLSEAARLFDPLGLLGPVVLRSKLFMQE-LWKS-K----------V------ -SWDI-P-LND--HQQQFWKSFRRDLEILD---T-FTVP--RWA--A------------- --PHLD-AA--NL-ELHG-FSDASES-AYG-ACIYIR--TISP-NG------IVSV-N-- LLTA---------------------------KSKV-APK--G-TEKL------------- ---DPS--------------------------IRLPRLELCGAL-LLS-HLFEKVESS-- -L-Q----N---Q---VRP---FF---------WT------------------------- -----------------------------------KTYYMPHHCI-------VRPE-NVT TKL-RVVFDASCASD-TG---VSLNDALIVGPVVQ--DELYSIILRFR---MPRF--VIV ADLEKMYRQVLVSPA--DRPLQR-----I------VFRSS---P-SE---------PL-Q TYELLTVTYGTASAPYLATRC-LQQL------------A----SDG-ESTH--P-KAAEA L-SKD--FYIDDL-LGGVA-S---EEEGITLCRELI-DL-LSSA-------GFKLH-KWA SNSP-RI-LQNIPPELREDRS--L-L-ELD---------------------------S-- STSPV-----------------KT--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------TP TLPFLNTGVDFCGPFY-------------------------------------------- ----------------------------LRPP--TRRA---APL------KS-FVA---V -FVCLS--TKAIHLELVSNLSADSF-----IASLKRF-AARR-GVPQTIYCDNATNFVGA RRTLN-E-------FLHLFRTQ-QN------------------RLDVT---RRCSAEGIQ ----FSFIPPRSPHFGGIWEAAVKSLKTHLRRTLA--N-----ALV----STEQF----- --QTL-----ITQIEALLNSRP--------LTQ------------L-------------- ----------------------SN--------SPE--D-------L-------------- ----------- >867/1-545 ---PTKREMLRLVMSIYDPLGLIASFVIQGKVIIQD-VWRT-K----------T------ -AWDN-Q-IPP--EIAERWMEWIAVLKQMD---G-LRIP--RCY--F------------- -PGYDPE-SYKNV-ELHV-FVDASAQ-AYA-AVAYFR--IID--HG------QIRI-A-- LVSS---------------------------KTKV-APL--R-E---------------- --------------------------------ISIPRLELMAAL-LGA-RLRKTVEEN-- -H------S-LTI---QRT---HF---------WS------------------------- -------------------------------------WYLPIGIV-------INEK-K-P GKV-RVIWDAAAK-V-DG---TSLNSMLLKGPDLL--TPLLSVMFPYR---ERQV--AVS ADIREMFLQISIRKE--DRSALL-----F------PYRDS---P-DL---------P-MS TMVSDVAIFGAACSPAHAQYI-KNMN------------A----DEQ-EAVF--P-RGAAA V-KKR--HYVDDY-VDSFD-T---AEEAVQVAMEVI-EV-HKRA-------GFHIR-NWM SSDS-TV-LEKL--SE-----ANRKPAKNMLS-----------------------E-QNT AF--E-----------------RV--LG-------------------------------- -----MAW---------------------------------------------------- ----------------------------------------------------------PY VRPFTYVGVDLFGPYL-------------------------------------------- ----------------------------VK--IG-R-----S-VA-----KR-WVC---L -FTCLT--IRAIHLEVVTNMSTDAC-----KKAFRRF-IARR-GAPQEVYSDNGTNFVGA NRDLQ-T-E------ISK-IYT-E----------------------LG---STFTNVQTQ ----WRFNPPAAPHMGGCWERMVRAVKSALEC-VP--V---E-RKL----DDESF----- --ATV-----LAEAESMINSRP--------LTF------------I-------------- ----------------------PL-------------ET--------------------- ----------- >87/1-560 ---FTKREVLSIIATLFDPLGLLGAAITTAKIVMQL-LWKF-R----------D-VNDRA LDWDQ-P-IPS--TVGEDWRKYLAQLHLLN---E-IRID--RCV--V------------- --IS-G-AV--ST-EIHC-FSDASEK-AFG-CCIYVR--SVDA-AG------GIKV-Q-- LLSS---------------------------KSRV-APL-------K------------- ---C----------------------------QTIPRLELCGAV-LSA-QLFEKVRES-- -L-K----T-P-----LQP---YF---------WT------------------------- -------------------------------------CFLPHHPV-------FKED-STT TKV-RVVFDASCATS-SG---VSLNDVLLVGPVIQ--EDLRSIILRSR---TKQI--MLV SDVEKMFRQIWVHPD--DRHLQC-----I------LWRSN---P-QD---------EV-S VFELKTVTYGTKPAPYLATRT-LKQL------------A----MDE-EATF--P-LGSRA A-SED--TYMDDV-ITGAD-S---VEQACELRKQLS-EM-AERG-------GFRLR-KWA SNCS-KA-LEGLPEDNLAIREVDG-I-NLD---------------------------P-- -DPSV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TV SRPFSQTGVDYCGPFY-------------------------------------------- ----------------------------VRPA--PRRP---A-V------KM-YVA---V -FICLC--TKAVHLELVSDLTTDRF-----IQALRRF-TSRR-GKAKDMYSDNGTNFVGA CNKLR-E-------LYNLVRSK-EH------------------QELVA---NHCLEEGTQ ----WHFNPPSAPHFGGLWEAAVRSAKSHLLKVIG--E-----TPL----SPEDL----- --NTL-----LVQVEACLNSRP--------LTP------------M-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >872/1-543 ---PTKRQVLRCVMALFGPLGLLSPFIIHGKVLIQD-LWRE-G----------T------ -EWDE-Q-ISD--VVNEKWKRWVRMIVYIA---E-IRIP--RCY--F------------- -HQATKE-TYKKS-EYHV-FVDASGE-AFC-CAIYLR--TINE-IG------EPQC-C-- LVAA---------------------------KSKV-API--K-P---------------- --------------------------------WSIPKLELQGCV-LGV-RWSKFVKEN-- -H------S-LPG---SKM---VF---------WC------------------------- -------------------------------------WYLPVGAV-------INPK-K-P GKV-RVIWDAAAK-V-EG---VSLNSQLLKGPDQL--SSLPAVLFRFR---QYGV--AVS SDIQEMFHQIRIRVE--DKNSQR-----F------LWRTN---P-SD---------V-PT IYLMDVATFGSTCSPASAQFV-KNLN------------A----EQH-RERY--P-EAASA I-IDD--HYVDDY-LASFG-S---EKEAAKVARDVR-YV-HGND-------GFKLH-NWR SNNI-RV-LEKL--DEV----QPKA-DKLLNL-----------------------V-DGG KS--E-----------------RV--LG-------------------------------- -----MLW---------------------------------------------------- ----------------------------------------------------------HH ERAFTYTGVDYFGPLL-------------------------------------------- ----------------------------VK--VG-Q-----S-NV-----KR-WIA---L -FTCLT--VRAVHLEVAYTMSTESC-----ISCVRRF-VGRR-GPPAEFFSDNGTNFQGA DRVLR-H-Q----------ISQ-G----------------------LS---NTFTNTNTR ----WNFIPPGAPHMGGAWERLVRSVKAAMAEA-Y--S---E-GKL----DDEGL----- --QTL-----VVEAESIVNSRP--------LTY------------L-------------- ----------------------PL-------------DS--------------------- ----------- >875/1-544 ---PTKRQVLRLVMSLFDPCGLIAHFIVHGKVLMQH-IWRT-G----------T------ -EWDD-E-IPI--ELHCMWRDWIQLLKRLI---E-VQVP--RCL--F------------- -GATNSK-VPATI-QLHV-FVDASEL-AYA-CCAYLR--IVQ--AG------VVHC-G-- IVAA---------------------------KTKV-APL--K-P---------------- --------------------------------LSIPRLELQACV-LGC-RLMETICVS-- -L------K-LTI---ERR---YL---------WT------------------------- -------------------------------------WYLPLGVV-------RNPK-K-P EKI-RLIWDAAAK-V-HR---LSLNDMLLKGPDMM--TSLFAVLLRFR---QRTI--AIC GDIREMFHQIRIIPQ--DKQSQR-----F------LFREH---Q-DD---------L-PQ VYVMDVATFGATCSPCSSQFV-KNKN------------A----REF-ESQF--P-KAAEA I-INA--HYVDDY-LDSVD-T---VEEAVQLVNEVK-YV-HALG-------GFEIR-NFS SNSS-EV-LRRL--GE-AER-----TSKSLDL-----------------------D-SS- ----E-----------------RV--LG-------------------------------- -----MVW---------------------------------------------------- ----------------------------------------------------------PQ VRAFSYTGVDYFGPIL-------------------------------------------- ----------------------------VK--QG-R-----N-LV-----KR-WVA---L -FTCLT--IRAVHLEVVHSLSTQSC-----VMAIRRF-ISRR-GAPAAFYSDNGTCFKGA SNILA-D-Q------LQK-IHE-D----------------------CA---LTFTNARTT ----WHFNPPSAPHMGGCWERKVRSIKVAMAALAE--H---P-RHS----SDEVL----- --ETV-----ILEAEAIVNSRP--------LT---------------------------- ------------------------------------------XSLSTINF---------- ----------- >879/1-573 ---PRKREVLAFVASIYDPLGLIANITIHGKILVQM-MHKE-T----------I------ -DWDQ-R-MSE--HMEQYWTHWLDLIKQAE---N-LSIP--RHV--S------------- -TPG--A---SDI-ELHT-FVDASER-AYA-ACIYVR--SKNK-DQ-------AIS-K-- LLCA---------------------------KSKV-APT--R-T---------------- --------------------------------KSIPRLELEGAL-LGA-RLLKQVRED-- -L------R-LVP---SKV---VL---------WT------------------------- -------------------------------------FYLPHFIV-------INRN-KPK PKP-RLVFDAAAV-V-KG---TSFNSTLLSGPDAT--TLLFGVLLRFR---EGQY--AVS GDIAEMFHQIKIIEK--DQHAQR-----F------LWRDC---N-PE---------KEPE VFVMQVMTFGSTCSHSCAQAV-KNFN------------A----SKF-TEKY--P-KAAIA V-VKQ--HYVDDY-LDSFD-T---EEEASQITNQVI-DI-HDTA-------GFFIR-NFI SNSR-SI-TETL--------PKVVKS-RYLXN-----------------------YSARR NLSLK-----------------R------------------------------------- ------FW----ESIGIRI-MTQLAIQ-XTXTNYPSKYFGRKI----------------- ----------------------------------------------------------IY APPFTNTGVDYFGPLE-------------------------------------------- ----------------------------VK--VH-R-----S-TE-----KR-WGV---I -FTCMT--TRAVHLELAEKLDTDSF-----FMCFRNF-QNRR-GKIAHMFSDNGTNFVGA ENKLK-E-------LILEINDR-M----------------------GK---GVAASLEIN ----WTFNPPGAPHFGGVWERLIQIIKNCLYEMLK--AYQ-N-SHP----SPDVL----- --RSA-----LIQAEFFLNSRP--------LTY------------I-------------- ----------------------PV-------------EN--------------------- ----------- >88/1-562 ---YTKREVLSQIAKLFDPAGWLSPFVVRAKIFMQK-IWLR-E----------L------ -GWDQ-P-LPR--DLATQWREFLEGYPALK---E-IRIP--RWV--R------------- -FHPAA-----KL-QYHA-FCDASQD-AYG-AAIFVR--IETK-EG------C-CT-H-- LLTS---------------------------KTRV-APV-------R------------- ---S----------------------------ISIPRLELCGAV-LLT-ELAALVISE-- -M------P-PHV---YET---FY---------WT------------------------- -------------------------------------FYLPHHAV-------FKPD-STT TKV-RVVFNASNPSS-NG---NSLNDILHAGPVLQ--SDLTIQILKWRPPLFFKY--VFN ADITKMYRQIRVNST--HGRFQR-----I------LFR-N---K-DG---------ELRC DYELDTVTFGVNCAPFLAIRV-LQQL------------A----QDI-RGQY--P-LASDI I-SNF--MYVDDV-LAGTH-T---KQSAVLAIEELR-LA-LESA-------GFPLR-KWT SNER-KL-LQEVPKEHLISAD----FLELE------------------------------ EASTA-----------------KT--LG-------------------------------- -----IRWQATSDSFFFI----------------PMVI---------------------- ----------------------------------------------------------TF SRPFTHTGVDFAGPFD-------------------------------------------- ----------------------------VKSY--VGRA---CKIT-----KG-YVC---V -FVCFT--TRAIHLEATSDLTTEKF-----LAAFSRF-FARR-GCPQHVYSDNGKTFVGA STSLSKD-------FIEAT------------------------RTSVL---SQHSLQNVS ----WHFNPPGAPHMGGLWEAGVKSFKSHFYKYTA--A-----GKY----TFEEL----- --TTL-----LAKIEACLNSRP--------ISP------------M-------------- ----------------------SE------------------------------------ ----------- >882/1-522 ---PTKREMLRLVMSIYDPLGLVASFVIHGKILIQE-VWRS-K----------I------ -DWDS-C-ISE--EIATYWTDWIAVLKRMD---G-LRIP--RCY--F------------- -SGYDPA-SFKTL-ELHI-FVDASEQ-AFA-AVAYFR--IVD--QG------QIRV-A-- LVSS---------------------------KTKV-APL--R-G---------------- --------------------------------LSIPRLELMAAL-LGA-RLRRTVEEN-- -H------T-LKV---QKT---CF---------WS------------------------- -------------------------------------WFLPIGVV-------VNEK-K-P GKV-RVIWDAAAK-V-DG---VSLNSMLLKGPDLL--TPLLSVMFPYR---ERQV--AVS ADIKEMFLQISIRPE--DRSALQ-----F------PYRDS---P-EL---------P-MS TMVTDVAIFGAACSPAHSQFI-KNLN------------A----SEQ-EAEF--P-RGAAA V-KKR--HYVDDY-VNSHD-T---AEEATEVAKEVI-EV-HKRA-------GFHIR-NWM SSDR-SV-VEQL--GE-----PN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PH VRPFTFVGVDLFGPYL-------------------------------------------- ----------------------------VK--VG-R-----S-VA-----KR-WVC---L -FTCLT--VRAIHLEVVANLSTDAC-----KKAIRRF-IARR-GSPQEIYSDNGTNFIGA NRDLQ-D-E------FRR-MST-E----------------------LG---STFTNAHTQ ----WRFNPPAAPHMGGCWERMVRAVKTALGC-VP--V---V-RKL----DDESF----- --ATV-----LAEAESMVNSRP--------LTF------------I-------------- ----------------------PL-------------ET--------------------- ----------- >883/1-546 ---PTIREVLRTLMMIFDPLGLIGHFLMFLKRILQE-IWRT-S----------I------ -GWDD-P-IEE--NQFELWLQWLKVLPEVT---K-VEIA--RCY--R------------- -TTTSVR-SSNDV-QMHI-FVDASEQ-GFA-AVVYLR--FHE--DD------NIEV-A-- LVAS---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQASV-IGV-RLATSIGQS-- -L------S-IRV---NRR---YF---------WT------------------------- -----------------------------------REWYLPMFPV-------LNPN-K-P GKV-RLVWDAAAK-T-HG---VALNSLLLKGPDLL--TSLLTVLVQFR---EFRI--GLC GDIRKMYLQILLKGD--TRLC-------F------FWKEN---E-QD---------IDPS VYAMRVLSFGVSCAPSIAQYV-KNVN------------A----QRY-EEQH--P-TAVNS I-VKQ--HYVDNM-LSSVD-T---EEEATDLARTVK-KI-HAEA-------GFEMR-NWI SNCP-EV-LSAL--NE---QGTE---EKELTL-----------------------AEG-V ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY ARPFTHMGVDYFGPLL-------------------------------------------- ----------------------------VS--IG-R-----R-QE-----KR-WIL---L -ATCLT--VRAIHLQVVYSLTTNSC-----IMALRNV-MARR-GIPAVIYSDRGTNFQGA SKELM-V-------AMENIDHE-R----------------------VA---TEFTTPYTT ----WTFIPPASPHMGGAWERLVRTVKQNLYKFQS------N-RSV----SMEVL----- --ENM-----LAEVENVVNSRP--------LTN------------I-------------- ----------------------PI-------------DN--------------------- ----------- >885/1-585 ---PRKREVLAFVASIYDPLGLIANITIHGKILVQM-MHKE-T----------I------ -DWDQ-R-MSE--HMEQYWTHWLDLIKQAE---N-LSIP--RHV--S------------- -TPG--A---SDI-ELHT-FVDASER-AYA-ACIYVR--SKNK-DQ-------AIS-K-- LLCA---------------------------KSKV-APT--R-T---------------- --------------------------------KSIPRLELEGAL-LGA-RLLKQVRED-- -L------R-LVP---SKV---VL---------WT------------------------- -------------------------------------FYLPHFIV-------INRN-KPK PKP-RLVFDAAAV-V-KG---TSFNSTLLSGPDAT--TLLFGVLLRFR---EGQY--AVS GDIAEMFHQIKIIEK--DQHAQR-----I------LWRDC---N-SE---------KEPE VFVMQVMTFGSTCSPSCAQAV-KNFN------------A----SKF-TEKY--P-KAAIA V-VKQ--HYVDDY-LDSFD-T---EEEASQITNQVI-DI-HDTA-------GFFIR-NFI SNSR-SI-TETL--------PKDRQE-QKSMK-----------------------LFSQK ESKFE-----------------KV--LG-------------------------------- -----VYWNTNNDAIGYTINMNKLSIEVLRQENLPRK---REVLAFVA------------ ----------------------------------------------------------IY APPFTNTGVDYFGPLE-------------------------------------------- ----------------------------VK--VH-R-----S-TE-----KR-WGV---I -FTCMT--TRAVHLELAEKLDTDSF-----FMCFRNF-QNRR-GKIAHMFSDNXTNFVGA ENKLK-E-------LILEINDR-M----------------------GK---GVAASLEIN ----WTFNPPGAPHFGGVWERLIQIIKNCLYEMLK--AYQ-N-SHP----SPDVL----- --RSA-----LIQAEFFLNSRP--------LTY------------I-------------- ----------------------PV-------------EN--------------------- ----------- >887/1-557 ----TKRIILSDFAKLFDPLGLVGPSLVPAKVFLQE-IWRS-K----------C------ -SWND-I-LPD--ELQKWWREFRGSLEGLT---H-LQVP--RWI--A------------- --FGSD-TI--SV-ELHM-FCDASTK-AYG-ACIYLR--CTSF-DG------TVTS-T-- LLTA---------------------------KSRV-APL--E-DLNK------------- ---KQKQ-------------------------ASIPRLELSSAL-TGV-HLFEKVVQS-- -I-K----I---T---AQP---YF---------WT------------------------- -------------------------------------YFLPHHAV-------LKPD-STT TKL-RVVFDASCAST-TG---VSLNDALMVGPVVQ--EDLTSITLRFR---LRKY--AMT ADIEKMYRMIKMHPM--DHPLQC-----I------LWRED---S-TK---------PL-R FFVLTTVTYGTSSAPYLATRC-LKKL------------A----EDE-KANF--P-AAINT I-IYD--FYVDDM-LKSVD-S---IEEATQLSKDLV-HV-LGTA-------GLTLR-KWS SNSR-EL-LDQIPPYLRDERS--S-L-DLE---------------------------L-- SYPTV-----------------KT--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------NP APPFLRVGVDYCGPFY-------------------------------------------- ----------------------------IQYP--YRKG---GPI------KC-FVA---V -FVCLV--VKAVHLEVVGDLTTQAF-----VAALRRF-VSRR-GRPEIIMCDNATNFVGA RRELD-E-------LRKLFNRQ-EF------------------VKVIT---EEASWENIN ----FKFIPAKSPNFGGLWEAAVKSMKEHLKRTLG--N-----TVL----VSDEM----- --ATL-----VAQIEAILNSRP--------RG---------------------------- --------------------------------VPF--E-------X-------------- ----------- >89/1-545 ---PTKRQMLRVLMSVFDPLGLIAQVLMYLKILLQD-VWRS-G----------I------ -GWDD-Q-VDD--TIFERWQTWLQVLPQIE---Q-ISIP--RCY--F------------- -SARSID-YE-RV-QLHT-FVDASEN-GIA-ATCYLR--FNR--DD------DVEC-S-- IVAA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRLELQAAL-IGA-RLARTLTEA-- -L------T-IQI---SRR---VF---------WS------------------------- -----------------------------------RTWYLPIFPV-------TNVN-K-P GKI-RMVWDAAAE-V-HG---VSLNSALLKGPDQL--CELFTILVQFR---EGRV--ALT GDVREMFLQVLMRPE--DQQCQR-----F------LWYDE---D-GT---------L--S VYVLQVMTFGACCSPSSAQFV-KNLN------------A----ERF-KGEY--P-AAVEV I-QKR--HYVDDM-LVSVA-T---EEEAIELAQQVK-KV-HAEG-------GFEIR-NWL SNSK-RV-VDAL--DE---NHTE---EKSLDL-----------------------STE-L AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF ARPFTHVGVDFFGPYE-------------------------------------------- ----------------------------IV--IG-R-----R-VE-----KR-WGM---L -ATCLT--TRAIHIEVAHSLSTDSC-----IMALRNF-ISRR-GKPRTIHSDRGTNFIGA NRELK-E-------ATLAIDQE-E----------------------LM---KEFVDADTT ----WQFLPPSSPHMGGSWERLIGSVKKNLMAILP------M-RKL----SDEVL----- --RNL-----LTEVENTVNSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >897/1-556 ----TKRIILSDFAKLFDPLGLVGPSLVPAKVFLQD-LWRT-K----------C------ -SWND-T-LPD--ELQTWWREFRESLEGLT---H-LQVP--RWI--A------------- --FGSD-TI--SA-ELHM-FCDASKK-AYG-ACIYLR--CTSF-DG------KVTS-A-- LLTA---------------------------KSRV-APL--E-DLEK------------- ---KRKQ-------------------------TSIPRLELSSAL-TGA-HLYEKVVQS-- -I-K----I---T---AQP---YF---------WT------------------------- -------------------------------------YFLPHHAV-------LKPD-STT TKL-RVVFDASCLSS-SG---VSLNDALMVGPVVQ--EDLTSITLRFR---LRKY--AMT ADIEKMYRMIKMHPL--DHPLQC-----I------LWREE---S-TK---------PI-R FFVLTTVTYGTSSAPYLATRC-LKKL------------A----EDE-KANF--P-AATET I-IYD--FYVDDI-LKSVD-S---VEEAGQLSRDLI-HV-LGTA-------GLTLR-KWS SNSR-EV-LDQIPPYLRDERS--S-L-DLE---------------------------L-- STPTV-----------------KT--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------TP APPFMRVGVDYCGPFY-------------------------------------------- ----------------------------IQYP--YRKG---GPI------KC-FVA---V -FVCLA--VKAVHLEVVGDLTTQAF-----LAALRRF-VSRR-GRPEILMCDNATNFVGA RRELD-E-------LRKLFNNQ-DF------------------IKAVT---EETSWENIN ----FKFIPAKSPNFGGLWEAAVKSMKEHLKRTLG--N-----TVL----VSDEM----- --ATL-----VAQIEACLNSRP--------I----------------------------- --------------------------------TPL--S-------S-------------- ----------- >908/1-540 ----TKRNILATVASLFDPSGLLGPTITMAKIFLQE-LWIW-R----------S-EEGHK LDWDD-P-VPS--TVGERWRRFHQVLPMLN---E-VRIN--RCA--I------------- --IP-E-AL--SL-ELHC-FSDASQK-AYG-GCVFIR--SRNA-EN------RTFV-S-- LLAS---------------------------KSKV-APL-------R------------- ---C----------------------------QTIPRLELCGAL-LTA-QLFEIVQKS-- -I-K----M-D-----IPA---FF---------WT------------------------- ------------------------------SHETVKRCYLPHHPV-------VKEA-STT TKV-RVVFDASCKTS-TG---ISLNDTLHVGPVIQ--DDLRSIILRCR---TKQI--MLV SDIEKMFRQINITPE--DRPLQS-----I------LWRQH---P-TE---------DV-A TYELGTVTYGTKSAPFLATRT-LHQL------------V----MDE-GKHF--P-LAAKS I-LED--TYMDDV-ITGAD-T---IEEATDLRKELV-RM-LQCG-------GFRLR-KWA TNEK-AV-IEGLPQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TM ARPFSRTGVDYFGPVL-------------------------------------------- ----------------------------VRPG--PRRV---A-V------KN-YVA---V -FICMV--TKAVHLELVSDLSTDRF-----LQALRRF-IGRR-GRCTDIFSDNGTNFVGA KNRLK-E-------LFALLNDD-QH------------------KESVD---KFCTNQGIR ----WHFNPPNAPHFGGLWEAAVRSTKHHLLRVVG--E-----HAM----STEDF----- --QTL-----LVQVESCLNSRP--------ITP------------L-------------- ----------------------SD--------DPN--D-------L-------------- ----------- >91/1-553 ---PTKRIVLSEIARLFDPLGLVAPVVVLAKEIMQR-LWKN-K----------V------ -GWDD-P-LDE--DTLKSWLEFRNSLKHID---M-IKIP--RFV--G------------- --LP-G-VE--YI-EVHG-FADASSR-AYG-AVVYLR--VVAA-NG------IKI--S-- LLCS---------------------------KSRI-APL-------T------------- ---P----------------------------LTIPKMELCAAL-LLS-RLIPKCISA-- -L-K----I-D-F---QRV---CL---------WS------------------------- -------------------------------------HYLPHHAV-------LKPS-SST TRL-RVVFDASARA--TG---PSLNDVLKIGPTVQ--DDLFSIILRFR---KHRY--AIT ADISKMYRRIHVDEK--HSGLQR-----I------FWRDN---P-DD---------PI-Q ILELTTVTYGTASAPYLATRT-LLQL------------A----RDE-SQRF--P-TASKV V-EED--VYVDDV-VTGAD-T---VEQAAQLRSDLT-DL-LNSG-------GFPVH-KWC ASDA-TI-LDTVPEEDREKFL------EFE---------------------------SKT LG---------------------------------------------------------- ------LW---------------------------------------------------- ----------------------------------------------------------VP SAPFSRTGVDFAGPVF-------------------------------------------- ----------------------------VK--VGLRKS---VRV------KA-YIC---I -FVCLA--TKAIHLELVSDLSSAAF-----VAALQRF-VSRR-GLVEEIHSDHGTNFAGA KSDLH-D-------LYLLFRDD-QT------------------KGKID---EFCCAREIV ----WKFIPPRSPNFGGLWEAGVKSTKTHLRKVLS--N-----ACL----TFEEF----- --YTV-----LTQIEAVLNSRP--------LFA------------N-------------- ----------------------SL--------DTH--E-------PSALTPGHF------ ----------- >911/1-557 ----TQRIVLSDSARLFDPYGLVGPVIVQAKMFLQE-LWKQ-K----------Y------ -SWDE-P-LSP--DLQSQWLEFRTNLDRID---A-VSVP--RWI--A------------- --FSDN-VV--SC-ELHG-FCDASEK-AYG-AVIYLR--CVTQ-KG------EVTV-R-- LVMA---------------------------KSKV-APL--E-DLKR------------- ---KKKR-------------------------QSIPRLELSSAL-LLA-HLYETVAQS-- -I-Q----I---P---AKT---YF---------WT------------------------- -----------------------------------HTYYLPHHAV-------MKPD-STT TKL-RVVFDASCATD-TG---VSLNDTLMVGPVVQ--SDLLSILIRFR---LHKY--AIV ADVEKMYRMINVVEQ--DQPLQR-----I------LWRES---V-EE---------PL-R TYQLSTVTYGTSSAPYLATRS-LKKC------------A----EEG-EQMY--P-AAANI I-KHD--FYVDDM-LAGAK-S---VKEGAKLCKDVL-SL-LGSF-------GFNLR-KWH SNQP-AI-LKSIPSHLHDKRD--L-L-DID---------------------------T-- -TSTV-----------------KT--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------TP APVFLRVGVDYCGPFN-------------------------------------------- ----------------------------VRQG--SRKA---APV------KC-YLC---V -FVCLV--VKAVHVEMVADLTTEAF-----IAALRRF-VARR-GKPEVIFCDNATNFVGA RREIS-E-------LHRLFRAE-QF------------------QNAVV---SDAATDAIE ----FKFIPAKSPNFGGLWEAAVKSLKGHMRKVIG--N-----TVL----RSDEF----- --LTV-----VTQIEACLNSRP--------ITP------------I-------------- ----------------------SS------------------------------------ ----------- >912/1-553 ----TKRKIMSYIAQIFDPLGLVGPTVTKAKLFMQR-LWAL-K----------T-PNSER YEWDQ-P-LPP--KLQQEWKEFHTTIDLLR---E-VRIP--RFA--S------------- --VV-D-AV--SI-QLHF-FADASDK-AYG-TCCYVR--AQS--AH------EVSV-K-- LLVS---------------------------KSKL-SPL-------S------------- ---AR---------------------------HTIARLELCAAH-LST-QLYKKVASS-- -L-R----N-V-----PPA---YF---------WS------------------------- --------------------------------------YLPHHPV-------FKLS-SAT TKT-RVVFDASCKTT-SG---YSLNDILLVGPVVQ--DDLLSLVIRFC---FHRI--ALS GDIEKMYRQVRLHDD--DQPYQR-----I------KWRSD---A-SE---------PI-A TYQLQTVTYGTASAPYLATKT-LQSL------------A----SDA-GNNF--P-SAAEP V-SKD--FYVDDL-LSGAD-D---VDSAIRIRREVS-AM-LDSA-------GLPMK-KWA SNSV-EV-LEDIPPEDRSVQP--W-Q-DLQ---------------------------D-- -PQSV-----------------ST--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------SP TRPFSVCGVDYCGPLF-------------------------------------------- ----------------------------VKSP--VRKR---GPT------KV-YVA---I -FICFS--TRAVHVELVSDLTSAAF-----LAALRRL-VTRR-GKISELHSDNATTFKGA SHALH-R-------VYQMLKLD-DTD-----------------RNRIL---SWCADNEIR ----WKFIPPRAPHFGGLWEAAVKSAKTHLLKEIG--N-----TSL----SYEDM----- --LTL-----LAQVEMCLNSRP--------LTP------------M-------------- ----------------------SS------------------------------------ ----------- >914/1-529 ---PSKREVLKVLMSIFDPLGLIAHFLIYLKVLLQE-IWRS-G----------A------ -QWDE-E-IND--ALFAKWQTWLRVLPEVE---S-VQIP--RCY--N------------- -LQDFDR-I---I-ELHT-FVDSSEN-GFA-AVSYLR--FSD--GT------HVEC-I-- LITA---------------------------KTRV-APL--K-F---------------- --------------------------------QSIPRLELQAAV-LGA-RLAQTIAES-- -L------S-IRI---TRR---CF---------WT------------------------- -----------------------------------RVWYLPVFPV-------INPN-K-P GKV-RIVWDAAAK-T-YG---ISLNSALLKGPDQM--GSLFSILLQFR---EHRI--GLT GDIREMFHQVEIREE--DRSCQR-----F------FWKDE---Y-GE---------V--A VFEICVMTFGACCSPSSAQFV-KNLN------------A----ERF-IGKY--P-QAVDV I-IKR--HYVDDM-LVSVK-T---EKEAIRIANQVK-EI-HSQG-------GFEIR-NWI SNST-TV-LRSL--GE---DEAK---IKNLDL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY SRPFTHVGIDFFGPME-------------------------------------------- ----------------------------VV--IG-R-----R-IE-----KR-WGM---L -ATCMT--TRAVHIEVAHSLNTDSC-----LMAIRNM-IARR-GIPRYIYCDRGTNFVGT NREIS-R-------IKKELDHE-E----------------------MM---KEFTSSETT ----WCFNPPSSPHMGGCWERLIRSVKNSLKALNL------P-RRP----SDEVL----- --RNA-----LTKIENTLNTRP--------LTH------------V-------------- ----------------------PI-------------ED--------------------- ----------- >916/1-540 ----TKRKILSTIATLFDPTGLIGAVIVEAKIFMQR-LWTI-E----------G-EDGQR LDWDQ-P-VPP--KVGEEWCKFYEHLPRLQ---E-VEVH--RCV--I------------- --IP-A-AV--IV-EVHC-FSDASMK-AYG-ACIYLR--SQDS-SG------NILV-R-- LLAS---------------------------RSKV-APL-------K------------- ---T----------------------------QSLPRLELCGAL-LGT-QLCQKVREA-- -I-R----F-K-----GEI---FF---------WT------------------------- ------------------------------ASEGSKRCYLPHHPV-------VKEA-STT TKV-RVVFDASCRTS-NG---ISLNDALYAGPVIQ--EDLRAIIIRGR---TRQI--MVV ADVEKMFRQIWIRPE--DRHLQC-----I------LWRSS---P-ME---------DV-R TYELNTVTYGTKPAPFLATRT-LQQL------------A----TDE-GRRF--P-SAAVA V-RED--TYMDDV-ITGAD-N---VEDATRLRCELQ-DM-MEAG-------GFHLR-KWA SNCS-KV-LEGVPV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TV SRPFSRVGVDYFGPVY-------------------------------------------- ----------------------------VRLG--PRRT---A-V------KA-YVA---L -FVCFC--TKAIHMELVTDLSTERF-----LQALRRF-ISRR-GKPSDIFSDNGTNFVGA RNQLT-E-------LMALLKNR-DC------------------HEKIS---KECNAEGIQ ----WHFSPPSGPHFGGLWEAAVRSAKKHLLKVLG--E-----NVL----TFEDM----- --NTL-----IVQIESCLNSRP--------LTQ------------L-------------- ----------------------TE--------DPE--D-------L-------------- ----------- >918/1-556 ----TKRLTLSYIAQLFDPLGLVGPVVVTAKAYMQT-LWTL-R----------D-ENGKI WEWDR-E-LPA--SLRDRWTTYHSDLPTLN---N-LRIN--RFV--L------------- --LS-K-PL--EI-ELHM-FSDASDI-GYG-TCAYLR--STDN-LG------RIKV-A-- LLTS---------------------------KSRI-APL-------K------------- ---R----------------------------QSTPRLELCGAL-LSA-ELYQRISTS-- -L-K----L-P-----FIV---VF---------WT------------------------- ---------------------------------K---YYLPHHPV-------IRDS-STT TKL-RVVFDASSKTS-SG---ISLNDALLVGPIVQ--DDLRSIVMRSR---THEI--VLI ADAEKMYRQVRHSSE--DYAYLC-----I------FWRMS---P-EQ---------PI-Q TFVLQTVTYGTASAPYLATRV-LKQL------------A----SDE-AATY--P-IAAKV V-END--FYVDDL-FTGAA-T---VAETIELREQLD-GM-LSKG-------GFSMR-KWA SNCE-AV-LEGIPPENRALQH--S-I-DFD---------------------------R-- -DQTI-----------------KT--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA ARPFSRVGIDFWGPIQ-------------------------------------------- ----------------------------LQPR--HRRD---API------KA-YVA---V -FVCFA--TKAVHLELVANLTTAKF-----LQAFRRF-VARR-GLCADVYTDNGKNFVGA ANELK-R-------L---LRSR-EH------------------KDQVA---QECAENSIR ----WHFNPPKGSHFGGLWEAAIRSAQKHFVRVLG--S-----RLI----AHDDM----- --ETL-----LAQIECCLNSRP--------LTP------------L-------------- ----------------------SE--------DPS--D-------L-------------- ----------- >92/1-557 ---PTKREFLSLVMSTFDPIGFLSCYMITAKLLMRE-IWRR-R----------V------ -KWDE-P-LPD--ELAAAFECWRQEMKYIE---E-FRCP--RYY--F------------- -GAGCVR----TL-QLHV-FVDSSQS-AFA-AAAYWR--ATYA-ND------DVQA-H-- FVCS---------------------------KTKC-APM--R-T---------------- --------------------------------MSIPRLELQAAV-LGT-RLMDTVKQE-- -H------G-VAI---SSC---TL---------WT------------------------- --------------------------------TNGKVWYLPHFGV-------ENPN-K-P GKI-RLVFDAAAK-V-ND---ISLNSALMKGPQRY--KSLPAVLFHFR---EGAV--GVC ADIKEMFHQVLIQPQ--DRCAQR-----F------LWRNG---E-DR---------RNPD TYEMQVMTFGAACSPCAADYV-KLVN------------A----SQY-SSTD--P-RAVLA I-KEY--HYVDDY-VDSFM-S---KDDAVAVSSRVR-EI-HANA-------GFDLC-RFS SSSA-DV-VKAL--NPQGSNTNVKWSESE------------------------------- ----E-----------------KV--LG-------------------------------- -----MYW---------------------------------------------------- ----------------------------------------------------------AN GWPFKFTGLDYFGPLL-------------------------------------------- ----------------------------VS--IG-R-----R-TE-----KR-WVA---L -FTCLT--TRAVHLEMAHDLSTDSC-----IIAMRNF-MCRR-GPVVRIRSDNGKNFVGA DKEAR-R--------FTDVFDPVK----------------------IQ---GELSSKGIE ----WIFNCPSNPAEGGVWERMVQCVKKVLAHTMK--E-----LAP----KEHVL----- --ENL-----LIEAENIVNSRP--------LTH------------L-------------- ----------------------PI-------------TVEQEAPLTPNDL---------- ----------- >923/1-549 ---TTKRIVLSSVMSLFDPLGLLAPFTTQGKMLIQD-LWRS-G----------C------ -DWDQ-A-IDD--DSYKKWRSWVSVLPKIA---D-LQIP--RSY--F------------- -GMVQSK-DFGHI-QLHI-FTDAGEN-AFG-CAGXLR--VVVD-GV-------VKC-S-- LAMA---------------------------RSKV-APL--K-Q---------------- --------------------------------LTIPRLELQAAV-LGA-RMSHQIKQN-- -L------S-LQL---HQT---FF---------WT------------------------- -------------------------------------WYLPLNVV-------LNPK-K-P NKV-RLVWDAAAT-V-GG---VSLNSNLLKGPDLL--TSLPSIISKFR---ERPV--AIG GDIREMYHQLRIRDS--DKQAQR-----F------LFRFN---S-TE---------P-PG IYIMDVATFGATCSPCSAQFI-KNRN------------A----LEH-SEQY--P-EAALA I-VDR--TYVDDY-FDSLD-S---EEEALRRAKEVK-FI-NAKA-------GFEVR-NWS LNSS-LV-LCGL--GE-----EKSSGLVHFHQ-----------------------D-KAT EN--E-----------------RV--LG-------------------------------- -----TIW---------------------------------------------------- ----------------------------------------------------------PY KRPFTFVGIDYLGPVD-------------------------------------------- ----------------------------VS--IG-R-----R-AE-----KR-WIV---L -FTCLV--VRAVHLEVAYNLTAQSC-----TMAIWRF-ICRR-GPAAEYFSGNGTNLKAA SKXFV-E-K------LQE-IGS-E----------------------CA---EEFTTARTK ----WHFNPPATPLMGGIWERMVRTVKNVMAV-LN--D---G-RRL----TDELL----- --LTT-----LAETEDMVNSRS--------LVF------------APQGSPQES------ ------------------------------------------------------------ ----------- >926/1-570 ---FTKRIILSDFAKLFDPLGLVGPSLVPAKVFLQE-LWRS-K----------C------ -SWND-V-LPV--ELQKWWRDFRESLEGLT---H-LQVP--RWI--A------------- --FGSD-TI--SV-ELHM-FCDASTK-AYG-ACIYLR--CTSF-DG------TVTS-T-- LVTA---------------------------KSRV-APL--E-DLKK------------- ---KRKQ-------------------------ATIPRLELSSAL-TGV-YLFEKVVQS-- -I-K----I---T---AQP---YF---------WT------------------------- -------------------------------------YFLPHHAV-------LKPD-STT TKL-RVVFDASCAST-TG---VSLNDALMVGPVVQ--EDLTSITLRFR---LRKY--AMT ADIEKMYRMIKMHPM--DHPLQC-----I------LWRED---L-TK---------PL-R FFVLTTVTYGTSSAPYLATRC-LKKL------------A----EDE-KANF--P-AATNT I-IYD--FYVDDM-LKSVD-S---IEEAAQLSKDLV-HV-LGTA-------GLTLR-KWS SNSR-EL-LDQIPPYLRDERS--S-L-DLE---------------------------L-- SNPTV-----------------KT--LG-------------------------------- -----IKW---------------------------------------------------- ----------------------------------------------------------NP APAFLRVGVDYCGPFY-------------------------------------------- ----------------------------IQYP--YRKG---GPI------KC-FVA---V -FVCLV--VKAVHLEVVGDLTTQAF-----IAALRRF-VSRR-GRPEIIMCDNATNFVGA RREYH-E-------LRKLFNRQ-EF------------------VKAVT---EEASWENIN ----FKFIPAKSPNFGGLWEAAVKSMKEHLKRTLG--N-----TVL----VSDEM----- --ATL-----VAQIEASLNSRP--------ITP------------L-------------- ----------------------SNDADDLEFLTPG--H-------F-------------- ----------- >928/1-557 ----TKRIALSQIARLFDPLGLLGPVVITAKIFMQA-LWTL-K----------D-GNDKI YSWDE-P-LPA--SMVQRWNNYMQELPLLN---N-LRID--RYI--L------------- --TP-S-PA--YI-QYHF-FSDASQH-AYG-ACCYIR--TADT-SG------AFRV-T-- LLTA---------------------------RSRV-APL-------K------------- ---Q----------------------------QSIPRLELCGAL-LAS-QLYERVSQA-- -L-E----L-R-----GPS---FF---------WV------------------------- -----------------------------------PXYHMPHHAV-------VKND-STT TKV-RVVFDASCKSP-QG---PSLNDALMVGPTVQ--QDIRSIIMRSR---SRRV--MLI ADAKQMYRQVLVDER--DTPLQR-----I------VWRQS---P-EH---------PL-I TYELLTVTYGTASAPFLATRV-LSQL------------A----NDE-QNTF--P-EAAEI L-RKD--VYVDDL-LSGAN-S---IEDATKLRNQLD-AL-LSKG-------GFQLR-KWA SNEE-AV-LEGIPADNRALQA--S-F-DLD---------------------------R-- -SQSI-----------------KS--LG-------------------------------- -----LHW---------------------------------------------------- ----------------------------------------------------------TA ARPFSVTGVDYWGPIT-------------------------------------------- ----------------------------LQRI--HRRA---APR------KA-YIA---V -FVCFV--TRAVHLELVIDLSTAKF-----LQALRRF-VSRR-GLCSDIYSDNGRNFIGA SNELR-K-------L---IRSK-EH------------------QQAVA---EECTANSIR ----WHFNPPKASHFGGLWEAAIHSAQKHFFRVLG--T-----HTL----AQDDM----- --ETL-----LAQIECCLNSRP--------LIA------------L-------------- ----------------------SD--------DPT--D-------F-------------- ----------- >93/1-537 ---PTKREALQVLMSIYDPLGFLSCYTIGLKILLQE-TWRS-G----------I------ -GWDD-E-LPE--PSQSCWTKWLKILSQAK---S-VHIP--RHY--S------------- -PLLHTA---DSV-ELHT-FVDASEY-GYA-AVCYLR--VIK--GF------DITT-N-- LVIA---------------------------KSKV-APL--K-P---------------- --------------------------------LSIPRMELLAAV-AGV-RLAHKTQLT-- -R------N-LNI---GEC---TF---------WT------------------------- -----------------------------------RIWYLPIFIA-------HNPN-K-P SKI-RLVWDAAAK-S-HG---VSLNDFMLTGPDLL--HPLSDVLMAFR---VGKI--AVC GDISEMFHQIRIKES--DIHVQRGSL--F------LWIDE---RT-----------QSPK EYVMRAMSFGISCAPCIAHYV-RDKN------------A----EDY-KMQY--P-RAYEA I-TRA--HYVDDY-IDSLN-D---EEEATKVSKAVK-LI-HSAG-------GFHIRFNWT SNSP-EV-LNAL---N----------E----E-----------------------SAP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SF QRPFTYTGVDFFG-IA-------------------------------------------- ----------------------------VN--VG-R-----H-KE-----KR-WGV---I -FTCLT--IRAVHIEIAYSLDTSSC-----VMCLSNF-MARR-GTPREIYSDNGTNFKAT EKVVK-E-------ELKNVDFN-N----------------------LT---IKY--DEIK ----WNFNPPGAPHMGGAWERLIRSIKTVLKSISP------N-YSF----NDESL----- --RNA-----LMNAEYVINSRP--------LTF------------V-------------- ----------------------SL-------------DAKDDDALTPNHL---------- ----------- >930/1-521 ---PTKREVLRTLMSVFDPLGLLSNVLVHLKILFQE-IWRS-A----------I------ -NWDD-E-IPD--NLDEKWEQWLRIIPHLQ---N-ISIP--RCY--R------------- -TLTTFG-ADTNV-QLHT-FVDASEM-GYA-AVVYLR--FQQ--GN------SVEC-A-- IVGA---------------------------KSRV-APL--K-F---------------- --------------------------------VSISRLELQSAV-LGS-RLANTITEA-- -L------S-FSI---NER---VF---------WT------------------------- -----------------------------------RFWYVPIFPV-------FNAN-K-P GKL-RIVWDCAAK-T-GN---VSLNSMLIKGPDQL--VPLNNVLYRFR---EYKI--GIS GDIREMFLQVKIAKE--DQNCQL-----F------LWKDT---P-DD---------EAPS TFVSQVMTFGACCSPSSAQFI-KNLN------------A----GKF-VEQF--P-RAVEA I-TKQ--HYVDDM-LASVE-S---EEEAIRLAEDVR-TI-HANA-------GFEIR-NWI SNSS-TV-LQA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AY TKPFSYVGVDYFGPMI-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WGV---L -ITCLT--IRAVHLEVAHSLSADSC-----IMALRAF-MARR-GVPLQIYSDRGTNFIAA SKELN-E-------ALKDMDQQ-K----------------------II---QEITSQHTQ ----WTFLPPLSPHMGGAWERLIQTVKVNLQAMLP------T-RHP----TDEVL----- --RNT-----LAEIENLINSRP--------LTH------------V-------------- ----------------------PV-------------DD--------------------- ----------- >936/1-584 ---PTKRVLLSVVMSFFDPLGLWAPFTVLGKIIVQD-LWRN-G----------C------ -SWDE-I-IDE--HSAKKWYRWIALLPSLQ---A-MEIP--RCY--F------------- -ADVKAS-DYQDL-ELHV-FADASEE-AYG-CVAYFR--VLVK-GE-------PRV-A-- LVSA---------------------------KSKV-APL--Q-Y---------------- --------------------------------MSIPRMELLAAV-LGA-RLAAFVKSN-- -H------S-VQV---QRV---FY---------HI------------------------- -------------------------------------WYLPLNVV-------LNPK-K-P GKV-RLVWDAAAS-V-QG---KSLNSELLKGPDLL--SSLPSVLCPFR---ERPV--AFG GDIAEMYHQLRIRSS--DKSAQR-----F------LYRPN---A-SG---------P-PI TYVMDVATFGATSSPCSAQFI-KNRN------------A----QDY-AEEY--P-DAVDA I-INK--HYVDDY-LDSTF-T---VSEAIRRAEEVT-YI-HSNA-------GFHIR-NWV SNSE-EF-QQHF--GR-----KPENHIVHFAS-----------------------D-KSS NTSME-----------------RI--LGTMPTQLRITHSDGSLXRSTSDNSLKTXTLTXN IFFPCYTI---------------------------------------------------- ----------------------------------------------------------PQ IRPFSYVGVDYFGPVV-------------------------------------------- ----------------------------VT--VG-R-----R-SE-----KR-WVC---L -FTCLV--TRAIHMEIAYSLSSQSC-----AMAIRRF-ICRR-GTPLEIFSDNGTNFQAA SKEFI-Q-E------IRC-IEM-E----------------------CA---DIFTDARTR ----WNFNPPAAPHMGGVWERLVRSAKEALKA-LH--N---G-GKL----SDEIL----- --LTI-----LSEAEDMVNSRP--------LTY------------V-------------- ----------------------PQ-------------ES--------------------- ----------- >94/1-553 ---PTKRTVLSVVMSIFDPLGLLGFFTVRAKIILQN-IWRA-G----------T------ -DWDE-S-LQE--KDQEDWKIWVKLLPKIN---E-VRIS--RCM--P------------- -KVCCAR----RV-QLHT-FVDASIN-AYA-ALVYLR--AEV--DG------IVHC-S-- LVAS---------------------------KTRV-APL--K-P---------------- --------------------------------VSIPRMELMAAV-LGL-RLTKFIEPE-- -L------S-VTV---CQR---IF---------WT------------------------- -----------------------------------SSWFLPIFTV-------TKPN-K-- NKT-RLVWDAAAK-V-KG---TSLNDVLLKGPDIL--ASLVGVLIRFR---ERPV--AVA GDISEMFHQVRVRPE--DQTAQK-----F------LWRSG---N-SA---------KAAE TYVMQVMTFGASCSPALANYI-KNRN------------A----ERF-RKES--P-RAVAA I-CRN--TFVDDW-LESTN-T---EDEMTELAMEVQ-RI-HLEG-------GFNMR-RWT SNSA-SV-VEAS--KN---QEET--CPRRWGF-----------------------LEK-T -H--I-----------------KV--XG-------------------------------- -----MWWPLKPKTLSVVM----------------------------------------- ----------------------------------------------------------PH TQPFTFTGVDCFGPFE-------------------------------------------- ----------------------------VA--VG-R-----R-HE-----KR-WGV---L -FTCLT--TRAVHLEIATSLSTDSF-----LCVLKAF-VARR-GVPRCILSDNGTNFRGA SRVLK-E-------HIERISTS-A----------------------VE---QQY--PTLE ----FKFNPPSSPHMGGVWERLVRSTKSILSEILP------K-AGL----KEEVL----- --RGA-----FADVEQILNSRP--------LTY------------V-------------- ----------------------PL-------------ES--------------------- ----------- >95/1-551 -----KRGVLSTLAKIYDPLGWLAPVTVIGKLFMQK-LWLA-E----------Q------ -NWDQ-E-LSD--NETTEWKSFRDNLVYLE---E-IRLP--RWI--K------------- --TQPN-----MLLQIHG-FADASEK-AYA-AVVYAK--I------------GEAV-T-- LIAS---------------------------KNKV-NPI-------K------------- ---NR---------------------------KTIPKLELCAAH-LLS-QLLQRVQQS-- -I------A-A-P---SEI---YC---------WS------------------------- ------------------------------------AYYLPHQAV-------IKEA-SLT TKL-RVVFDASAKTT-NN---RSLNDVMWIGPRLQ--KDIFDIIVKWR---KWQY--VVS ADIEKMYRQINIDLN--DQKYLH-----I------LWRIS---P-QK---------KL-R IYKLTTVTYGTASAPYLATRV-LAEI------------A----NR--CQ-D--K-VISEI I-RDE--FYMDDL-MTGGN-T---VQESKRKVQQVS-RE-LEKA-------GMNLR-KWI SNKS-EI-IEEVIDTGDNKVL------------------------------------KID ENEAI-----------------KT--LG-------------------------------- -----LQW---------------------------------------------------- ----------------------------------------------------------TV SSPFHNTGIDFAGPYH-------------------------------------------- ----------------------------IRCS--KNRG---QKTF-----KG-YIA---V -FVCLS--TKAIHLEVVSDLTTDAF-----LAAFRRF-VARR-GKCANIYSDNGTNFVGA ARRLD-E-------EFKKAVQD-NV--------------------QVA---PVLEREQIS ----WHFSPPAGPHFGGIWEAGVKSVKYHLKRVIG--D-----SNL----TYEEL----- --ATL-----LCQIEAVLNSRP--------LYT------------T-------------- ----------------------GE--------DMD--N-------NEVLTPGHF------ ----------- >96/1-571 ---PTKRKVLAAVNSIYDPLGMVTPVTIKGRILMRS-IWEL-G----------I------ -GWDD-V-IKG--DPVKKWQEWLNDLKRLH---D-VSIP--RCY--S------------- -QYLSIA---TKV-ELHV-FCDASSK-AYA-AAAYIRVSYKDA-EA----ATKYDV-M-- LIAS---------------------------RARV-SPL--K-H---------------- --------------------------------VTIPKLETLAAV-MGC-RLAETIENE-- -M------H-LKF---DKR---FF---------WT------------------------- -------------------------------------WFLPHFAV-------INPK-K-P GKV-RVVFDAAAI-C-NG---TSLNENLLTGPDWL--SSIVGVLIRFR---LNTI--AFA ADIKEMFNQVKIAKE--DAVSQC-----F------LWRNM---N-TQ---------IPPT VYQMTSMIFGATSSPFIAQFV-KNHN------------A----AIH-KNEA--P-EAAQA I-IEN--HYVDDY-LDSKA-T---VREAVEIIHAVI-KI-HAAG-------HFQIR-NFI CNNH-DV-LQGI--PE-----DLRGPLTRIRL-----------------------GEKGD IS--Q-----------------KV--LG-------------------------------- -----MIW---------------------------------------------------- ----------------------------------------------------------TF QKPFTSVGMDYFGPFY-------------------------------------------- ----------------------------TK--DG-R---GSSGRYNKCLRKR-YGV---L -FTCLT--SRAIHAEIAHSLTTDSC-----ILAIRRM-MARR-GEIKTLWSDNGTNLRGA SRELT-E-------ALEEIDIQ-A----------------------AR---GELTQKGIE ----WKFIPANSPNFGGCWERLIGCFKRTLEAVLS--V---E-SNP----TDEVL----- --QTL-----FCEAEHLVNSRP--------YIL------------E-------------- ----------------------SD-------------DPDDGLGLCPNDI---------- ----------- >97/1-548 ---PTKREVMSFIASIYDPIGLINPVVVTCKNLFQR-ICVS-K----------L------ -GWNE-N-LYG--DLLSTWNLILSDFKSVF---Q-IAVP--RWYMSP------------- -GLGNINN--VKF-ELHG-FSDASVK-SFG-CCVYLR---FFNANF------S-RA-S-- LIAS---------------------------KSRV-APL--G-K---------------- --------------------------------NTMPRLELSATL-LLA-KLLASIYDQ-- -L------I-SIYNI-SNI---IY---------WT------------------------- --------------------------------------YLPHRPV-------CRK-DKTS TKV-RIVFDASST---LS--GPSLNDCINAGPSLA--TPLFFILLRFR---ANKY--AFI ADIEKAFLQIALDKN--DRNYLR-----L------IWFDD---I-YNINNSNLFSSAL-A TYRICRVPFGVTSSPFLLNAT-LIYH------------A----ERYCLNDN--N-IS-SK L-LQS--LHIDDL-ISSCV-T---IEEGILFFNKCK-DI-LKEG-------GFNLR-KFE SNSS-AF-EKQINGDNYERQ---------------------------------------- -TNT------------------RV--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------NS DFAFKSIALDYAGPLY-------------------------------------------- ----------------------------IKDIYGD--C---TLN------KA-WIF---L -FTCCS--SRSILLDLVADCSSRSC-----IMGIRRF-IGRR-GVPEIIYSDNGSQFVS- --------------------------------------------TETQ---YFAANHSIK ----WKFNAPSAPWWGGMFERLVRMTKRCLKKALK--N-----SKS----SYEEV----- --RTL-----LSEIEMVLNNRP--------LTY------------L-------------- ----------------------YN--------NQG--D-------EA-LTPNHL------ ----------- >98/1-544 ---PTKRLVASCVMGFFDPLGLLSPFTIHGKIVIQY-LWRS-G----------C------ -DWDQ-E-IDP--DSWQLWKRWTALLPVVE---A-IRIP--RCY--I------------- -GGAKSA-EVDSL-EVHI-FTDASEH-GYG-CVAYLR--AVIN-GA-------VHC-S-- LMMS---------------------------RAKV-API--K-R---------------- --------------------------------QSIPRLELMGAV-LGA-RISQTVLDM-- -H------S-YRI---CRT---VF---------WT------------------------- -------------------------------------WYLPLNVV-------QNPK-K-P EKV-RLVWDAAAT-V-QG---ISLNSQLLAGPDML--VPLVKVLAGFR---EWSI--AFG GDLKEMFHQLKIRAE--DKQKQR-----F------IFRKH---S-ED---------P-PS IYVMDVATFGSTSSPCSAQFV-KNRN------------A----EEF-ASQY--P-EASAA I-IHR--HYVDDY-FDSVD-T---EEEAVKRAQEVR-LV-HQKG-------GFEIR-NWV SNSP-EV-LRSL--GE-----EKPAAPVHFGR-----------------------D-KQT SN--E-----------------RV--LG-------------------------------- -----VIW---------------------------------------------------- ----------------------------------------------------------TQ HRPFSSVGLDYLGPVE-------------------------------------------- ----------------------------VT--VG-R-----R-KE-----KR-WVA---V -FTCLA--VRAVHLEVVHSLTTESC-----RMAITRF-SSKY-GKPQQIFSDNATCFRGA SNEMV-R--------MEK-INQ-E----------------------CA---EAVCSSTTA ----WHFIPPGTPHMGGVWERMVRSVKEAMRA-LD--D---G-RKL----TDEIL----- --VTT-----LAEAEDMINTRP--------LTY------------L-------------- ----------------------PQ-------------DS--------------------- ----------- >980/1-554 ---TTKREVVSFAASLYDPLGLLSPVHVRAKLFIXS-LWKL-N----------L------ -HWDT-P-ISD--ELNTNWTNIAHDLREVT---N-ICVN--RHY--F------------- -ADNTDN-KNNNI-EIHA-FSDASTK-AYG-GAVYIK-------SG-------NQT-S-- LVMS---------------------------KTRV-APT----NKNT------------- --------------------------------LTLPRLELMAAL-TTT-RLSKFVSNA-- -L------S-VKYNT-TRR---VL---------WS------------------------- ------------------------------QDDTTSGHYLPHRSV-------KRD--SSS TPI-RIVYDCSATSG-IG--QPSLNDCLETGPPLX--NDLTAMLVRFR---SNPV--ALA SDIEKAFLQIRLADE--DHKYTK-----F------LWLSD---I-ND------LTSEF-T TYQFTSVLFGAMCSPFILNAA-IKTL------------I------NNHPNI--P-AA-ND L-QQN--IYVDDV-VTGSR-D---TNEAMKFYEDST-KL-LSTH-------GFNLR-SWS TNDQ-TT-RDVIKQDSKANP---------------------------------------- NT-TV-----------------NM--LG-------------------------------- -----VKW---------------------------------------------------- ----------------------------------------------------------QR SPPFHICGVDYTGALH-------------------------------------------- ----------------------------VKN--PA-GN---TTT------KT-YVC---L -FTCAV--TRAIHLELVPDMTTTSF-----MLAFRRF-AARR-STPSMLISDNASTFLLA ASELR-E-------IISN--------------------------PEVK---SMLSDHRIT ----WKFIPKRAPWFGGFYERMIGITKTTLKKVLG---------------NSCEL----- --ETI-----LTEAEASINNRP--------LTY------------V-------------- ----------------------ST--------HVN--D-------LTPLTPSQL------ ----------- >983/1-545 ---PTKRQVLRTLMMVFDPMGFIAHILMFLKVLLQE-IWRT-P----------V------ -GWDD-P-IED--AQFDKWLTWLTIFPKIE---S-VEVA--RCY--R------------- -LSTSMS---ASV-EMHT-FVDASES-GFA-AVVYLR--FKE--GS------VIEC-A-- LAGA---------------------------KTRV-APL--K-F---------------- --------------------------------LSIPRSELQAAL-LGV-RLADTIVKS-- -L------S-INI---DQR---YF---------WT------------------------- -----------------------------------RIWYLPIFVV-------TNPN-K-P GKL-RLVWDAAAT-A-HG---VSLNSFLLKGPDQL--TSLLSVLIRFR---EFRV--AVC GDIKEMFHQVQMRDV--DQQCQR-----F------FWRDD---G-N----------TEPS VYVVQVMTFGACCSPSIAQHV-KNSN------------A----KQF-EPDH--P-EAVDA I-VKR--HYVDDM-LVSTE-T---EEEAIRLARDVK-NI-HMNA-------GFDIR-NWI SNSS-TV-QAAL--NE---VAAV---EKNMDI-----------------------SET-P AT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF SRPFTYMGVDYFGPIL-------------------------------------------- ----------------------------VS--VG-R-----R-TE-----KR-WGV---L -ATCLT--TRAIHLQIVHTLTTSSC-----VMAIRNV-MARR-GTPAVIYSDRGTNFQAT SKELK-A-------AIQHLDHD-K----------------------LA---KEFTSSRTQ ----WTFIPPLTPHMGGAWERLIRTVKQNLVAMQH------S-RLP----TDEVL----- --HNA-----IVEVENIVNSRP--------LTD------------I-------------- ----------------------PL-------------DN--------------------- ----------- >988/1-516 ----TKRLIMSYIATIFDPLGLLGPTITKAKIYMQG-LWAL-K----------D-DNNQT YDWDK-H-LPR--RLQEQWKEFHTTLDLLK---Q-VPIP--KYV--I------------- --EF-N-AV--SV-QLLF-FADASER-AYG-ACCYVR--SES--PA------KVTV-R-- LLTS---------------------------KSKV-APL-------S------------- ---AL---------------------------QTIARLELNAAE-LSV-RLFKKVNSS-- -L-K----I-N-----IPV---TF---------FS------------------------- -------------------------------------------------------S-STT TKT-RVVFDASCKTT-SG---RSLNDMLLVGPVVQ--QDLLSLTLRFR---IRSI--ALV ADVEKMYRQILVHQD--DHPLQK-----I------LWRSS---P-TE---------PI-S TYELQTVTYGTASAPYLATRT-LQQI------------A----LDA-QAVH--P-AAAMA I-IND--FYVDDW-LSGAE-D---TPSATQLLKEVS-EI-LFAA-------GFPLK-KWV SNAP-EV-FRD------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SP TRPFSTCGVDYCGPLF-------------------------------------------- ----------------------------VKSP--VRKH---GPR------KV-YVA---I -FVCFS--TRAVHIELVSDLTTSAF-----LAALRRF-IARR-GKIVEIHSDNGTAFKGA SHALH-R-------VYEMLKRN-EDD-----------------RNKIF---NWCANNEIR ----WKFIPPRAPHFGGLWEAAVKSAKTHLLKELG--N-----ITI----AYEDL----- --LTL-----LAQVEMCLNSRP--------LTP------------M-------------- ----------------------GI------------------------------------ ----------- >989/1-618 ---YSRRTVSRKIGSDFDPQGLMTPLMLTSKLFQRV-LWQD-E----------F-----A YKWDT-P-LNK--NHESQWKELLDQTEGFI-----KELP--RNI--L------------- -DQSNKN-------KIIC-FCDASQN-ATA-YCFYAH-------NK-------YGM-N-- IFLG---------------------------KSKV-KSLKEK------------------ --------------------------------WTIPKLELHALT-MGT-QRMLSVVQC-- -LQKGDIGV-------SEA---II---------LTPLKTNKIATLPDNYRLTLKRLIGIV KTTPLEVKKMIQEIFEDQVKKNILEIVTAQTPKGEWTHYSPIQPV-------LTP-HKAT TKC-RVVVDASAHYK-GN---DSLNDAIEQGPTLL--PDILDILIRFR---SGET--VIL ADVEKAFLQVRLNEE--DRDLTR-----I------LWIKD---I-NL----PATPDNV-E VYRFTRVLFGLNASPFLLAAT-IMLH------------L------ENHANS--K-LA-SK I-NEN--LYVDNL-IFTFDGS---AREALELYKEFK-AI-FADA-------NMNLR-EFM GNSD-EF-NDNIPEVDK--A---------------------------------------- QKSDL-----------------KV--LG-------------------------------- -----IPY---------------------------------------------------- ----------------------------------------------------------KE TAPFQHTGLDYFGPIS-------------------------------------------- ----------------------------YRKE-DNTVA------------SC-WGC---L -FICAT--TRLVHIQLIVRPDTSCF-----LKAFQRF-VSLC-GKPNAIVSDNAPHFILA DKILQ-D-------IAETTTK-------NCNF-----------NNEVK---KFLGDAKIE ----WKFITPYAPWQGGMYERMMRSIKQSMFKGIG--R-----SIL----SLDDI----- --HTT-----FTEVAAALNSRP--------LTY------------V-------------- ----------------------GQ--------NLD--S-------GFVLRPIDF------ ----------- >99/1-553 ----TKRMMYSEIAKFFDPLGLVSPVIVLAKLLAQR-LWQL-K----------I------ -GWDD-P-VDE--ATAQEWQELQTSLSHLH---Q-IDIP--RCV--T------------- --FN-E-VI--AY-ELHG-FSDASTV-AYG-ACVYLR--SLFA-DG------SAKL-R-- LLTS---------------------------KSKL-APL-------H------------- ---D----------------------------LSIPRKELCAAL-LLT-RLVQKVLPA-- -L-D----M-T-F---REI---VL---------WC------------------------- ---------------------------------------MPHHAV-------LRPS-SSS TKC-RVVFDASAKSSASE---LSLNEVLQVGPVVQ--NDLHFIVLRFR---KFKI--AFS GDVSKMYRQVLHAKQ--DHRFLR-----I------FWRPH---P-LQ---------PL-R VLELSTVTYGTASAPFLATRC-LVQL------------V----EED-GDAF--P-IASRI V-KEE--TYMDDV-LSGAD-S---VEEAIEAQRQLK-QL-LELG-------GFPIH-KWC SNSE-EF-LEHIPEEDREQKK------PLE---------------------------ERG VNEAI-----------------KV--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------VP SPPFAVTGVDYAGPFI-------------------------------------------- ----------------------------IK--QGARRP---ALI------KA-YVS---V -YVCMT--TKAVHLEAVSDLSTDAF-----LASLKRF-IGRR-GMVQQLHSDNATNFRGA HHELN-E-------LYRQFQDQ-QS------------------VSTIE---DFCRSREIE ----WHFIPPDAPEFGGLWEAAVKSAKTHLKRIVG--N-----VKL----TFEEL----- --STV-----LVEIEAVLNSRP--------LFT------------I-------------- ----------------------SN--------DPA--D-------P-------------- ----------- >992/1-561 ---PTKSQVMGSIAKIYDPLGFVDPIKMVAKLFMQR-LWTL-K----------E-ADGSM WPWDK-E-LPE--VLQKQWATFCSHLGELN---N-VSVP--RFT--N------------- -PTMSD-----DL-QYHI-FCDASEK-GYG-ACAYLR---CKT-EE------ICVA-N-- LLVS---------------------------KSKV-APL--A-K--R------------- --------------------------------LTIARLELCAAL-LAS-NLYNFIRKA-- -RLP--------E---APC---YL---------WT------------------------- -----------------------------------PCFYLPHHAV-------WKAD-STT TKC-RVVFDASCKCR-TG---HSLNDLLLAGPRLQ--EDIEPILLRFR---MKAV--AMV ADIEKMYRQVLVSES--DRNLQR-----I------LWRED---S-SH---------PI-A VYQLNTVTYGTTCAPYLAIRT-LRKI------------F----EDH-ENEF--P-MAKT- W-YDD--FYVDDL-LSGAE-T---EAEAIHIRDQVI-EM-MDRA-------GFKLR-KWA SNRA-SA-LDGLP-NEELAQPEQK-ERSLD------------------------------ -TKPI-----------------ST--LG-------------------------------- -----LTW---------------------------------------------------- ----------------------------------------------------------SQ AKPFAVSGVDYCGPVF-------------------------------------------- ----------------------------LKGS--HRRA---APV------KA-FIA---V -FVCFV--TRAVHLELVSDLSTPAF-----LAALRRF-IARR-GTVTEIHSDNGTNFKGA ANELN-K-------LYELFNST-DH------------------QQSIW---TWTAEQQIR ----WKFIPPRAPHFGGLWEAAVKSMKRHLLRVLG--T-----SSV----SHEDM----- --VTL-----LAEIESCLNSRP--------ISP------------L-------------- ----------------------SD--------SPN--D-------Y-------------- ----------- >995/1-535 -----RRTVSSDIASKFDPMGYLTPLLLLPKLFQRE-LW-D-T----------T-----Q YGWAT-K-LSE--QHEDEYRKLIQDINGFT-----IKMP--REI--V------------- -LKTGKN-------SIIT-FCDASKE-ATA-CCVYVK-------ND-------KGT-H-- IILG---------------------------KSHV-RPLKEK------------------ --------------------------------WTIPKLEMHALL-LGT-EKTIKVVKA-- -LQIGQT---------------------------T------------------------- -------------------------------------HYNALQAV-------ITP-SKTT TKC-RIVVDASAHYK-DK---PCLNDCIEQGPTIL--PDIQDMIIRFR---SGQT--VLI SDVEKAFLQVFLHED--DRDVTR-----V------LWFKD---I-NK----PVNEDNI-I VYRFTRVLFGLNVSPFLLGQT-IIHH------------L------RSLKDD--P-II-RE M-PHN--LYVDNS-IITADEN---AENVIQIYKKVK-KN-FKDA-------NMNLR-EFR SNCK-TV-NDGIAEEDK--S---------------------------------------- KEEDM-----------------KV--LG-------------------------------- -----IWW---------------------------------------------------- ----------------------------------------------------------NK QRPFGSTGLDNFGPIQ-------------------------------------------- ----------------------------YRKD-DGTLA------------NA-YGT---I -FTCTT--TRLIHVETVKNASALEF-----IQAFRKF-VAIR-GRPTKIVSDNGTNFVLG QKIIE-E---------AF--E-------RSDC-----------PPD---------MHKID ----WKFITPYAPWKGGVYERMVKSVKEAFYKAVG--R-----SKL----TFEEL----- --TTV-----LYEATASINQRP--------LTK------------L-------------- ----------------------ED--------DIN--A-------ETPIRPCDF------ ----------- >997/1-557 ---PTKRAILSAIARMYDPLGYLSPVIFYAKVILQD-MWKS-N----------C------ -DWDE-L-GPP--STCAKWKTFLAQTSSLS---D-IKIP--RCI--T------------- --SIED-----VSYMIVG-FSDASQR-GYS-AVLYLH--ATTT-S-------GCHV-H-- VLRA---------------------------KTKL-API-------K------------- ---P----------------------------MSIPRLELSGAL-LLA-RLFQSCKSV-- -M--------T-K---LGIQRATW---------FT------------------------- -----------------------------------SAYTIPHHAV-------LKLN-NSQ LKL-RVVFDASCRTA-KG----SLNDHMYVGPKLQ--LDIGEVITNFR---THQV--VFT TDIVKMYRQILVNPK--DRKFQH-----I------LWRST---S-AE---------AI-Q TYELCTVTYGETASPFLAQRT-IHQL------------I----TDE-GASF--P-LAKKA L-SED--IYVDDI-ATGAN-K---MEDAIQLQDQLI-AL-LAKG-------GFQLS-KWA SNCP-KL-LQNLEPSQL--AVSAVQLSDED------------------------------ -IQGV-----------------KL--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------AE GKVFDHVGVDFGGPFH-------------------------------------------- ----------------------------IRES--MRRK---ADTG-----KA-YLC---L -FICMS--TKAVHLEVVSACSTEAF-----LAAFERF-IARR-GKPMHVYSDCGTNFIGA ANRIK-E-------LTRLLRSS-EA------------------QGKIL---RTTVPQEIQ ----WSFNPPSAPHFGGLWEAGIKSAKSILYKVVG--E-----SVL----TFEEL----- --ATI-----FCRVEGILNSRP--------LSS------------L-------------- ----------------------GT--------D-----------------PAAV------ ----------- >998/1-618 ---YSRRTVSRKIGSDFDPQGLMTPLMLTSKPFQRV-LWQD-E----------F-----A YKWDT-P-LNQ--NHESQXKELLDQTEGFI-----KELP--RNI--L------------- -DQSNKN-------KIIC-FCDASQN-ATA-YCFYAH-------NK-------YGM-N-- IFLG---------------------------KSTV-KSLKEK------------------ --------------------------------WTIPKLELHALT-MGT-QRMLSVVQC-- -LQKGDIGV-------SEA---II---------LTPLKTNKIATLPDNYRLTLKRLIGIV KTTPMEVKKMIQEIFEDQVKKNILEIVIAQTPKGEWTHYSPIQPV-------LTP-HKAT TKC-RVVVDASAHYK-GN---DSLNDAIEQGPTLL--PDILDILIRFR---SGET--VIL ADVEKAFLQVRLNEE--DRDLTR-----I------LWIKD---I-NL----PATPDNV-E VYRFTRVLFGLNASPFLLAAT-IMLH------------L------ENHANS--K-LA-SK I-NEN--LYVDNL-IFTFDGS---PREALELYKEFK-AI-FADA-------NLNLR-EFM GNSD-EF-NNNIPEVDK--A---------------------------------------- QKSDL-----------------KV--LG-------------------------------- -----IPY---------------------------------------------------- ----------------------------------------------------------KE TAPFQHTGLDYFGPMS-------------------------------------------- ----------------------------YRKE-DNTVA------------SC-WGC---L -FICAT--TRLVHIQLIVRPDTSCF-----LKAFQRF-VSLC-GKPNAIVSDNAPHFILT DKILQ-D-------IAETTTK-------NCNF-----------NNEVK---KFLGDAKIE ----WKFITPYAPWQGGMYERMMRSIKQSMFKGIG--R-----SIL----SLDDI----- --HTT-----FTEVAAALNSRP--------LTY------------V-------------- ----------------------GQ--------NLD--S-------GFVLRPIDF------ ----------- >BEL259/1-551 ---YTKREVLSQIARLFDPAGWLAPFIIRSKIFMQE-IWLQ-N----------L------ -GWDD-K-LPT--EMSQRWQSFLEEYSDLN---Q-IRVP--RWI--W------------- -YQPEV-----VI-EHHG-FCDASQR-AYG-AAIYIR--VEMG-QK------I-LT-R-- LLTA---------------------------KTRV-APV-------K------------- ---T----------------------------VSLPRLELCGAV-LLT-EMVTAILPH-- -M------P-SAS---SDI---RC---------WT------------------------- ------------------------------P-----SYHLPHHAV-------VKPE-STT TKL-RVVFNASSPSA-NG---ISLNDILHAGPVLQ--SDLTIQVLKWR---YFQY--VFS ADITKMYRQIWVDPK--HTPFQR-----I------LFR-N---K-EG---------DI-R DFELKTVTFGVNCAPFLAIRV-LQQL------------A----EDI-QVPF--P-NASRI I-QQH--MYVDDV-LAGAN-S---VNEAQSSIRELQ-AA-LSAS-------GFPLR-KWT SNNK-SV-LKDVPAEHLLHSE----FLDID------------------------------ AESTA-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------SF SRAFTYTGIDYAGPFE-------------------------------------------- ----------------------------IKNY--TGRA---CLIT-----KG-YVC---V -FVCFS--TKAIHLEPTSDLTTEKF-----LAAFARF-VARR-GCPQRVHSDNGKTFVGA AALISRD-------FLQAI------------------------KESVT---DAYSHQGLV ----WRFIPPGAPHMGGLWEAGVKSFKTLFLKSTS--V-----RKY----TFEEL----- --ATL-----LAKIEACLNSRP--------LSP------------M-------------- ----------------------SE--------DPS--D-------L-------------- ----------- >BEL262/1-557 ----TMRTILSMIAELYDPLGLISPVIITAKVLMQS-LWRL-K----------L------ -SWDD-T-VPE--ELQRNWIRFRAELPELK---D-FSIP--RFA--F------------- --AH-Q-YR--QA-EIHC-FTDASEL-AYG-ACIYIR--SEAE-DG------SIHV-N-- LLAS---------------------------KSRV-APL-------K------------- ---A----------------------------LTIPRLELCGAL-LGA-RLHEKVMAA-- -M-E----I-K-F---VAH---RF---------WT------------------------- -----------------------------------TCCYLPHHPV-------FKET-SST TKM-RVVFDGSAPTS-TG---HSLNDALLVGPVIQ--DDLLSLIIRFR---KFQV--ALV PDLEKMYRQVLVHPE--DRPLQR-----Y------G-----------------------G AYELRTVTYGLAPSSFLATRT-LQQL------------A----EDE-GDAF--P-TAKDT L-KKQ--LYMDDL-IAGSN-S---VDGAIQLREELS-AL-AQRG-------GFTFR-KWC SNSL-AV-LSDVPAEQLATKS--S-L-RFD---------------------------D-- -KETI-----------------ST--LG-------------------------------- -----ICWEPEIDTFQFNI----------------------------------------- ----------------------------------------------------------TV NEVFSCTGLDYCGPLY-------------------------------------------- ----------------------------LRPT--HRKA---APN------KC-YIC---V -FVCMS--TKAVHLELVGDLSTNSF-----LMALDRF-VYRR-GKPKHIYSDNGTNFIGA KNELH-Q-------IYKMLFND-SA------------------DSKIA---KHLAKEEIQ ----WHLIPPRAPNFGGLWEAAVKVAKTHLIRQLG--S-----SRL----SSEEM----- --TTV-----LVKIEGCMNSRP--------LVP------------L-------------- ----------------------SE--------DPN--D-------L-------------- ----------- >BEL269/1-540 -----KRVVLSTLAKIFDPLGWLAPVTVSGKLFIQK-LWIN-K----------S------ -EWDQ-E-LSI--EDKNYWEKYKENLLLLE---N-IRIP--RWI--N------------- --SNSS-----SVIQIHG-FADASEK-AYA-AVVYAK--V------------GPHV-N-- IIAS---------------------------KSRV-NPI-------K------------- ---NR---------------------------KTIPKLELCAAH-LLS-ELIQRLKGS-- -I------D-N-I---MEI---YA---------WS------------------------- ------------------------------------KYFLPHQAV-------IRDS-SLT TKL-RVVFDASAKTT-NN---KSLNDIMWVGPRVQ--KDIFDIIIKWR---KWEF--VVS ADIEKMYRQIKIDNN--DQKYQY-----I------LWRNS---P-KE---------KI-K TYKLTTVTYGTASAPYLATRV-LVDI------------A----DK--CK-N--Q-VISAI I-RND--FYMDDL-MTGAD-S---VEEANKLITLIP-HE-LQKV-------GFNLR-KWI SNNS-KI-LTTVEDTGDNKVL------------------------------------NII ENECV-----------------KT--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TM TFPFLNTGIDYAGPYY-------------------------------------------- ----------------------------VKCS--KNRG---QKTF-----KG-YVA---V -FVCMA--TKAIHLEMVSDLTSDAF-----LAALRRF-IARR-GKCSNIYSDNGTNFVGA ARKLD-Q-------ELFNAIQE-NI--------------------TIA---AQLEKDRID ----WHFIPPAGPHFGGIWEAGVKSMKYHLKRIIG--D-----TIF----TYEEM----- --STL-----LCQIEACLNSRP--------LYT------------I-------------- ----------------------VS--------EK-------------------------- ----------- >Gypsy/1-432 --------ILEYDSDTINFLG-ESPCYPSSDEEMKL-----------------L------ --------VDT--GAAKNFIRPFKGLKGVR---P-VQFP-------F------------- --------------TIHS---------IHG-VTTITK---------------KCFV-S-- IFNL---------------------------KATF------------------------- --------------------------------FLLPDLTSFDAI-VGL-DLLKQAGAS-- ---------------------------------LC------------------------- -----------------------------------SPYNNPIWVVDK-----KGTDDAGN KKM-RLVLDF-----------RKLNERTV--PDRYPMPNISMILGNLG---KAKY--FTT LDLKSGYHQITLAER--DREKTS-----F--------------AVNG------------G KYEFRRLPFGLRNAASIFQRT-----------------I--------------DDILREQ I-GKFCYVYVDDVIIFSED-----ENAHVKHVDWVL-KS-LYDA-------NMRIS---- AEKS-RF-FKK------------------------------------------------- ----------------------SVSFLG-------------------------------- -----FIV---------------------------------------------------- ----------------------------------------------------------VP THVGEILHIDIFSTDK-------------------------------------------- --------------------------------------------------KY-------F -LTCVDKFSKFAMVQPILSRTIEDL-----KAPLLQL-MNVF-PKAKTIYCDNEPSLKSQ TIVAMLE-----------------------------------------------NHFGVS ----ISNAPPLHSVSNGQVER-FHSTLIELARCLKIDK-----GIS----DTVEL----- --VLLATARYNKSIHSVINKKP-----------------------A-------------- ----------------------EV------------------------------------ ----------- >Pao253/1-525 ---PTMRNMYKTLASQYDPLGFIIPFTTRAKVLIQD-LWKQ-N----------L------ -GWDD-LIEPA--QLRNKWLTWVGEIPTLL---Q-LQFP--RLY--T------------- -PVWPDN-PPVTR-ELHI-FCDASER-AYG-SVAYLR--ASDD-QG------HVAV-T-- FVLA---------------------------RSRV-APR--K-C---------------- --------------------------------LSMPRLELSAAL-TGA-QLAQVIQNE-- -L------T-LPI---DSV---TL---------WS------------------------- ---------------A---------------NKSNESWYIPHHVV-------HHN----- NKD-RIVFNCSFQ-H-QG---QSLNSQLLPGPTLG--PSLLGVLLRFR---QHAV--AVS GDIKGMFHQVRLLPK--DKQVLR-----F------LW-RD---LCRD---------REPD IYEWQVLPFGTTCSPCCAIFA-LQHH------------A----QGH-KGD---MPKLVNI V-ENS--FYVDNC-LYSTP-T---AKEAKDVVDGLR-QL-LAEG-------GFDLR-QWA CNVP-SV-IQH------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------L ----------------------------------------------------------LY KPPFYSTGVDCFGPFT-------------------------------------------- ----------------------------VK--VG-R-----R-QE-----KR-WGV---L -YKCMT--TRCVHLDLLEQLDTDAF-----LLSLRRF-IARR-GKPMELLCDNGTNFVGG DRELR-E-------TFNAMAPK------------------------LQ---EQLAEQRIR ----FRFNPPSAPHFGGTWEREVKSVKSALRVILR--E---Q--SV----PEAVL----- --QTL-----LVEVEGILNSKP--------LGY------------I-------------- ----------------------SS-------------DV--------------------- ----------- >Pao255/1-548 ---PTKKEVVRVLMSIFDPLGLLANVLMFLKVLIQE-IWRS-G----------I------ -GWNA-T-ITP--EQYEKWLVWLKVIEKVE---A-VSIP--RCY--R------------- -QITSSS-SKTNV-QLHT-FVDASTN-GCA-TVAFLR--FEE--ED------RIEC-A-- FVAG---------------------------KTRV-APN--K-L---------------- --------------------------------TSIPRLEIDAGT-MGV-RLAQKIMEG-- -L------R-IVI---HQR---FF---------WT------------------------- -----------------------------------RVWYLPIFVV-------TNPN-K-P GKL-RIVWDAAAE-V-RG---ISLNSVLLKGPDQV--TSLVDVLLRFR---EYRT--AVT GDIKEMFHQVRVHLD--DQHCQR-----F------LWNNG---A-PG---------STPS VYVMQVMTFGASCSPSCAQFV-KNIN------------A----ERF-AEDS--P-AAAKA I-IND--HYVDDM-LSSVE-T---EQEAIKLASSVR-DI-HGQG-------GFEIR-GWR SNSK-AV-LAAL--NS---QECE---DKNLSE-----------------------ASQ-F ST--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AF TRPFSYTGVDYFGPIS-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -LTCLV--TRAVHIEIAHTLTTDSC-----ILALRNF-MAIR-GTPLELISDQGTNFIGA DRELK-K-------AYQKVDQN-Q----------------------LI---REFTTTNTK ----WTFNPPSSPHMGGSWERLVQSVKKVLNQMKL------P-RNP----SDEVL----- --RNT-----LLEISNIVNSRP--------LTY------------I-------------- ----------------------PV-------------ED--------------------- ----------- >Pao258/1-576 ---PTKREYLSLVMSTFDPLGFLCCLMVTAKLLLRE-IWRQ-K----------I------ -QWDE-P-LPE--ELSKAFAIWRKEMDAVG---Q-FRCP--RHY--F------------- -GRGAVR----AV-ELHV-FVDASQA-AFA-AVAYWR--VTYE-DD------DVQV-S-- FVSA---------------------------KTKC-APM--R-T---------------- --------------------------------MTIPRLELQAAV-LGT-RLMNTVKQE-- -H------S-VVI---TDL---LL---------WT------------------------- ---------------A---------------VRSDRLWYLPHFSV-------ENPN-K-P GKV-RLVFDAAAK-V-GG---TSLNSELDKGPQHY--KPLPAVLFHFR---EGAV--GVC GDIKEMFHQVLIRPE--DRCSQR-----F------LWRDG---D-DE---------RDPD VYEMNVMTFGAACSPSAAHYV-KTMN------------A----LKY-RDSD--P-RAVKA I-TDY--HYVDDY-VDSFA-T---ESEAISVSTRVK-EI-HKDA-------GFELC-QFS SSSP-TV-ETAL--GPG-RVKSVGWGEAE------------------------------- ----E-----------------KI--LG-------------------------------- -----MRWQVATDDFRFNVEYHRVPSSVLSGDRVPTKREYLSLVM--------------- ------------------------------------------------------------ ----HRTGL-----LW-------------------------------------------- ----------------------------AT--AG-D-----C-VP-----SQ-GEALGRL -VYVFD--DKGDSPGVAHDLSTDSC-----IIAIRNF-VCRR-GPVYRLRNDNGKNFVGA DREAR-R--------FGDVFEMEK----------------------LQ---SELSSRSIE ----WVFNCPANPSEGGVWERMVQCVKRVLRHTLK--E-----VAP----RDHVL----- --ESF-----LIEAENIVNSRP--------LTH------------L-------------- ----------------------PV-------------DA--------------------- ----------- >Pao260/1-547 ---PTKREVTSAVMSTFDPLGLIAPLLIKGKRMLQD-IWRA-G----------T------ -DWDE-V-ISE--EAHHQWLEYIGSLSTLQ---Q-LRIP--RCL--T------------- -PAAGPG-------QLHT-FVDASET-AYA-AACYWR--AETE---------VIHV-A-- LIAG---------------------------KARV-SPA--K-P---------------- --------------------------------VTIPRLELQAAL-LGA-RLARTVTEE-- -I------D-LQV---TDR---YF---------WS------------------------- -----------------------------------RTFYLPHFAV-------VHPM-K-- KKI-RIVFDAASR-Y-EG---KSLNDALLPGPDLL--QSLFGVLLRFR---QGPV--AVV ADIKEMFLQIKIREQ--DRDSLR-----F------LWRGE---D-RA---------SKPR EYRMTSVIFGAASSPATAIFV-KNRN------------A----EEH-QASH--P-EAVKA I-VRN--HYMDDY-LQSFA-T---IEEAIDTAATVD-SI-HKEA-------GFELR-QWA SNEQ-RV-LDGL-------------QREEASP-----------------------TEVAI GSNEE-----------------KT--LG-------------------------------- -----LRWLIKDD----------------------------------------------- ----------------------------------------------------------YG SHPFTCTAVDYFGPMF-------------------------------------------- ----------------------------VT--IG-R-----R-KE-----KR-WGA---L -FTCLT--TRAVHLELVPSLSTSSM-----IMALRRM-SARR-GTPRVIYSDNGTNFIGA NHELR-E-------EIGKLKKN-E----------------------LI---DAANQEGIR ----WKFIPPGAPNMGGAWERMVRTVKTALSAILN--E-----RSP----PEEVL----- --HTL-----LTEVEHTVNSRP--------LTH------------L-------------- ----------------------SV-------------NPEDE------------------ ----------- >R1000/1-522 ----TMRNIYRVLASQYDPLGYIIPFTTRAKIIVCQ-LWAK-E----------R------ -EWDD-PLLPS--ELLQAWQNWEAELNHLP---K-ITMP--RCY--V------------- -SATLDV-PEAER-ELHI-FCDATAE-AYG-SVAYLR--TEH--QG------QIEL-A-- FIHA---------------------------RSRV-SPK--R-Q---------------- --------------------------------QSVPRLELCAAL-TGA-QLAKLLHNE-- -L------S-LKI---KDT---FL---------WS------------------------- ---------------A---------------AQSTESWYLPHHIV-------THN----- GKH-RVVFNCSYT-Y-NG---ENLNKQLLPGPTLG--PTLLGVLIRFR---EHRV--AIS GDIKGMFHQVRLLTK--DKPLLR-----F------LW-RD---LNPE---------NPPD VYEWQVLPFGTTCSPCCATFA-VQRH------------V----FSH-CQQ---GDKLRQS V-EHS--FYVDNC-LQSTS-S---AVEARELIDGLR-SI-LASG-------GFEIR-QWA SNEA-TV-VRH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LM KPPFFSTGVDCFGPFL-------------------------------------------- ----------------------------VK--RG-R-----S-NE-----KK-WGI---I -FKCMT--TRCVHLGLLANMDTDSF-----LMALRRM-VARR-GTPSEILADQGTNFRGG DKELQ-T-------AFTAMSPD------------------------LQ---AQLAKQKIQ ----FHYNPPNAPHFGGMWEREIRSVKAALRTIIG--P---Q--TL----TEEVL----- --KTL-----LIEVEAILNAKP--------LGY------------V-------------- ----------------------SS-------------DL--------------------- ----------- >R1002/1-539 ---CTRRGVLSKVCSVYDPLGFLAPFTLTAKILLQE-LCRI-R----------C------ -GWDD-L-LPS--NLQRQWSLWLKELEKMA---D-FKMD--RCL--K------------- -PAGMDE--LTNV-QLHH-FADASTL-GYG-TVTYLR--METK-QD-------VHV-T-- FLLS---------------------------KARV-APL--K-S---------------- --------------------------------VTIPRLELTAAV-LAA-RVDKMLRAE-- -M------Q-FPL---VDS---VF---------WT------------------------- ---------------K---------------QDEGKVWYIPHHGV-------YHPK-K-- QTL-RVVFDCGAA-F-KG---TSLNDQLLQGPNLT--NSLLGVLVRFR---QEPI--AFM ADVKAMFHQVKVAEE--DTDFLR-----F------LWWPD---GDIN---------QDSV EYRMKVHLFGAVSSPSCACYA-LRRT------------A----EDN-KDDF--PEKVIDT I-HTN--FYMDDC-SKSVP-S---EEEAVLMIKDLT-DV-CLAG-------GFQLI-KWI SNSR-IV-LQSV-------PEEHRAQ------------------------------G--- ------------------------------------------------------------ ------------------------------------------------I----------- ----------------------------------------------------------PD LPPFSNVGVDYFGPVE-------------------------------------------- ----------------------------VK--RG-R-----S-IV-----KR-YGV---I -FTCMA--SRAVHLEVAYSLDTDSC-----INTLRRF-ICRR-GQVTQIRSDNGTNFVAA EKELK-E-------SLRSWNQN-K----------------------IQ---RAMLQKGVQ ----WSFNPPGGSHYGGIWERVIRMVKIILNSILH--Q---Q--IL----DDEGF----- --HTV-----LCEIEAILNDRP--------ITK------------L-------------- ----------------------SD-------------D--------PNDL---------- ----------- >R1008/1-551 ---YTKREVLSQIARLFDPAGWLAPFIIRSKIFMQE-IWLQ-N----------L------ -GWDD-K-LPT--EMSQRWQSFLEEYSDLN---Q-IRVP--RWI--W------------- -YQPEV-----VI-EHHG-FCDASQR-AYG-AAIYIR--VEMG-QK------I-LT-R-- LLTA---------------------------KTRV-APV-------K------------- ---T----------------------------VSLPRLELCGAV-LLT-EMVTAILPH-- -M------P-SAS---SDI---RC---------WT------------------------- ------------------------------P-----SYHLPHHAV-------VKPE-STT TKL-RVVFNASSPSA-NG---ISLNDILHAGPVLQ--SDLTIQVLKWR---YFQY--VFS ADITKMYRQIWVDPK--HTPFQR-----I------LFR-N---K-EG---------DI-R DFELKTVTFGVNCAPFLAIRV-LQQL------------A----EDI-QVPF--P-NASRI I-QQH--MYVDDV-LAGAN-S---VNEAQSSIRELQ-AA-LSAS-------GFPLR-KWT SNNK-SV-LKDVPAEHLLHSE----FLDID------------------------------ AESTA-----------------KT--LG-------------------------------- -----IRW---------------------------------------------------- ----------------------------------------------------------SF SRAFTYTGIDYAGPFE-------------------------------------------- ----------------------------IKNY--TGRA---CLIT-----KG-YVC---V -FVCFS--TKAIHLEPTSDLTTEKF-----LAAFARF-VARR-GCPQRVHSDNGKTFVGA AALISRD-------FLQAI------------------------KESVT---DAYSHQGLV ----WRFIPPGAPHMGGLWEAGVKSFKTLFLKSTS--V-----RKY----TFEEL----- --ATL-----LAKIEACLNSRP--------LSP------------M-------------- ----------------------SE--------DPS--D-------L-------------- ----------- >R1021/1-540 -----KRVVLSTLAKIFDPLGWLAPVTVSGKLFIQK-LWIN-K----------S------ -EWDQ-E-LSI--EDKNYWEKYKENLLLLE---N-IRIP--RWI--N------------- --SNSS-----SVIQIHG-FADASEK-AYA-AVVYAK--V------------GPHV-N-- IIAS---------------------------KSRV-NPI-------K------------- ---NR---------------------------KTIPKLELCAAH-LLS-ELIQRLKGS-- -I------D-N-I---MEI---YA---------WS------------------------- ------------------------------------KYFLPHQAV-------IRDS-SLT TKL-RVVFDASAKTT-NN---KSLNDIMWVGPRVQ--KDIFDIIIKWR---KWEF--VVS ADIEKMYRQIKIDNN--DQKYQY-----I------LWRNS---P-KE---------KI-K TYKLTTVTYGTASAPYLATRV-LVDI------------A----DK--CK-N--Q-VISAI I-RND--FYMDDL-MTGAD-S---VEEANKLITLIP-HE-LQKV-------GFNLR-KWI SNNS-KI-LTTVEDTGDNKVL------------------------------------NII ENECV-----------------KT--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TM TFPFLNTGIDYAGPYY-------------------------------------------- ----------------------------VKCS--KNRG---QKTF-----KG-YVA---V -FVCMA--TKAIHLEMVSDLTSDAF-----LAALRRF-IARR-GKCSNIYSDNGTNFVGA ARKLD-Q-------ELFNAIQE-NI--------------------TIA---AQLEKDRID ----WHFIPPAGPHFGGIWEAGVKSMKYHLKRIIG--D-----TIL----TYEEM----- --STL-----LCQIEACLNSRP--------LYT------------I-------------- ----------------------VS--------EK-------------------------- ----------- >R778/1-557 ----TMRTILSMIAELYDPLGLISPVIITAKVLMQS-LWRL-K----------L------ -SWDD-T-VPE--ELQRNWIRFRAELPELK---D-FSIP--RFA--F------------- --AH-Q-YR--QA-EIHC-FTDASEL-AYG-ACIYIR--SEAE-DG------SIHV-N-- LLAS---------------------------KSRV-APL-------K------------- ---A----------------------------LTIPRLELCGAL-LGA-RLHEKVMAA-- -M-E----I-K-F---VAH---RF---------WT------------------------- -----------------------------------TCCYLPHHPV-------FKET-SST TKM-RVVFDGSAPTS-TG---HSLNDALLVGPVIQ--DDLLSLIIRFR---KFQV--ALV PDLEKMYRQVLVHPE--DRPLQR-----Y------G-----------------------G AYELRTVTYGLAPSSFLATRT-LQQL------------A----EDE-GDAF--P-TAKDT L-KKQ--LYMDDL-IAGSN-S---VDGAIQLREELS-AL-AQRG-------GFTFR-KWC SNSL-AV-LSDVPAEQLATKS--S-L-RFD---------------------------D-- -KETI-----------------ST--LG-------------------------------- -----ICWEPEIDTFQFNI----------------------------------------- ----------------------------------------------------------TV NEVFSCTGLDYCGPLY-------------------------------------------- ----------------------------LRPT--HRKA---APN------KC-YIC---V -FVCMS--TKAVHLELVGDLSTNSF-----LMALDRF-VYRR-GKPKHIYSDNGTNFIGA KNELH-Q-------IYKMLFND-SA------------------DSKIA---KHLAKEEIQ ----WHLIPPRAPNFGGLWEAAVKVAKTHLIRQLG--S-----SRL----SSEEM----- --TTV-----LVKIEGCMNSRP--------LVP------------L-------------- ----------------------SE--------DPN--D-------L-------------- ----------- >R780/1-509 ----TKRAILSKLSGVYDPLGIISPTTVEGKRIYRD-ACEE-K----------R------ -GWND-E-VSE--STKKAWFKWTGQL---R---N-VKIP--RSL--V------------- ----RDLRRVKTI-HLHV-FADASNV-ACS-AVMIAI--V-ED-TT------GVVK-G-- LLTS---------------------------KSRI-SKR--N------------------ --------------------------------TSIPRLELVSGH-MAA-NMVKNVCAA-- -L------KRWPI---TSV---TV---------WM------------------------- --------------------------------------------------------NAQT TKV-RMVFDASCKPH-PL--ANSVNECMHTGPPLQ--PLMWDIMIRAR---MAPH--LIL GDLEKAFLQIAIKEE--DRDAFR-----F------LFNIN---D-KEEH----------- -FRFARVPFGAEASPFMLGAT-IHHH------------L----DRQPTELT--N-TV-NA L-REN--TYVDNL-MQTGN-D---VDELKEFREEAT-RI-FESA-------KFPAH-KWE SDLQ-DL-DTEPNPS--------------------------------------------- ----------------------KI--LG-------------------------------- -----HVW---------------------------------------------------- ----------------------------------------------------------EG GRPFETVGVDFAGPLN-------------------------------------------- ----------------------------YKL--A--KN---GKG------KC-YII---I -FTCAT--SRAVHLEVTKSQTAEEF-----QRKLNAF-ITRR-TRPVRIVSDNASVFKAT ATWIK-K-------IRKS--------------------------EVLQ---DYLAKQGIR ----WQFNLSRSPWWGGMYERLIREIKKTLYKTMG--R-----SSL----HYEQM----- --EEV-----VVDIERHLNNRP--------LTY------------V-------------- ----------------------ES------------------------------------ ----------- >R785/1-550 ---CTKRNILSVIARIWDLMGFVAPVTLWAKLIIKS-LWAN-N----------I------ -DWDE-T-PRP--EIVAAWHRFVSELPILE---N-VRIP--RHTGI-------------- -------VMECIV-SLLG-FADASEK-AYG-GVVYLH--VYFPQTN------KFTI-T-- LVCA---------------------------KSRV-APL--R-C---------------- --------------------------------VSLARLELCGNL-ILA-KLMRAIIDS-- -Y------S-HRCKI-SNV---FA---------FT------------------------- ---------------------------------------IPHHGI-------VRKD-KST TKL-RVVLDGSMKSS-SG---LALNDILQVGPNLQ--NDLFRIILNFR---LFNV--AIS ADIRQMYLRILVKDE--DRKFLR-----M------LYRFD---P-SE---------EI-K LYEFTRVPFGLCCSPFLAIRT-VRQL------------V----TDE-GSQF--P-LAAPV A-DSD--VFTDDL-ATSCA-N---EETAVELSNQLI-KM-FHAG-------GFDLV-KFS SNSP-EV-LSKIPSSHREFEVIEF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QE TKAFYHTGIDYAGPLR-------------------------------------------- ----------------------------IIPY--RRRG---VRSQ-----KA-YIC---L -FICLV--TKAVHLELSTDLSTAAF-----LNAFKRF-IARR-GPIKVVYTDCGTNFLGT HSYLK-E-------MYKLISSE-QY------------------ADKFA---NELRDNNID ----WKFNPPSAPHFGGIWEGNIRSVKTHLNKIVG--N-----QLL----TFEEM----- --LTT-----LAQIEALLNSRP--------LSV------------L-------------- ----------------------SS--------DPC--D-------PQALTPAHF------ ----------- >R789/1-538 ----TKRKILSAINSVFDVLGFSAPVLITGKILYSR-LCLS-K----------I------ -GWDH-Q-LPK--ELLEEWQTWIKTISNKR---T-ILIP--RCV--V------------- ----SGR--IIEL-ELHG-FSDASKL-AVC-ACIYVV--TSHQ-NS------KT-S-N-- LLVA---------------------------KARI-APK--D------------------ --------------------------------LSIPRLELVAAH-TLS-KLMNHVRKT-- -L------VNYNI---SKV---FN---------WV------------------------- -------------------------------------HYIPHQAV-------IKE-NAES TKM-RVVYDCSARKD-AQ--SPSLNDCLEVGPSLQ--PLIFDILIRNR---MNKL--CVL ADIKKAFLQIRIQDM--DRDAQR-----L------IWYED---L---KK------MKL-M ELRFTRVIFGSSSSPYILGAT-IKKH------------I----SKYKDIYP--K-TV-VA L-EED--TYVDDL-QAGGE-T---EEELIRFKYEST-QI-LNEA-------GFQLH-KWH SNVR-EL-ENN---------V--------------------------------------- E-------DKST----------KI--LG-------------------------------- -----HPW---------------------------------------------------- ----------------------------------------------------------DN VEPFAVSGVDFAGPLK-------------------------------------------- ----------------------------YKV--P--KN---SIK------KC-YVA---L -FTCAS--TRAVYLKLCHDLSAVEF-----QRVLKEF-VARK-GPPQMIISDNAKTFVAT GKWLL-T-------LKND--------------------------ENIA---NYLAIQAIK ----WRFNLSRAPWWGGLFERLIGIMKKSLSKTIG--K-----GML----TFNEL----- --EEV-----LLDVECSMNNRP--------LCY------------Q-------------- ----------------------GD--------QFD--N-------QV-LTPNVL------ ----------- >R790/1-538 ----TKRKMLAVINRIYDLLGLASPVTVIGKVLYSK-VCLS-E----------K------ -RWDE-A-ITD-VEIVREWNKWLKSMKACP---S-VSIP--RSV--V------------- ----DQH--VTRI-ELHG-FSDASKT-AVS-AAIYVV--AHHA-DS------SVRQ-T-- LLVA---------------------------KSRV-APK--N------------------ --------------------------------QSIPRLELVGAH-TLT-KLMTHVKEV-- -L------QGQPI---QIY---QC---------WV------------------------- -------------------------------------HYIAHTMV-------TRD-DAQT SKL-RIVYDCSARED-DN--TPSLNDCLEVGPPLQ--PMLFDILLRNR---MNRL--CLT GDIQKAFLQIKVDTK--DRDCMR-----L------FWYDN---L---KD------RNI-V EYRFARVIFGSGPSPYILGAT-LQKH------------V----ASYSDKYP--E-TV-YQ L-LTN--TYVDDV-QTGGD-D---PEQLLRFKQEAS-EI-MESG-------GFQLH-KWH SNVL-EA-EESTSAERADRAV--------------------------------------- D-------RPPV----------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------EF SEPFDVTGVDFAGPIY-------------------------------------------- ----------------------------YRT-----KS---EQG------KA-YIA---L -FTCAA--TRAVHLKLCPDLSAPNF-----QRALKEF-VARR-GCPQMIVSDNGKTFVAT GKWLS-V-------LKKD--------------------------ESLS---NYLASQAII ----WRFNMSRAPWWGGFFERLVGVMKNALSKAVG--R-----SLL----NYCEL----- --EDA-----LLDVETVMNNRP--------LVY------------Q-------------- ----------------------GE--------EF-------------------------- ----------- >R791/1-592 -----KRSILSEISKLFDPLGWLSPVLVRAKLMLQD-LWIN-G----------V------ -DWDS-P-LTG--ELLEQWQMLRSDLPDLA---Q-LRIP--RWF--G------------- -SSSQT-----SW-ELHG-FSDASQR-AFV-AAAYMV--IPGQ-KS------A------- LIMS---------------------------KTKV-API-------K------------- ---T----------------------------ESLPRLELCGSV-LLV-RLLKHLLDG-- -L------L-LKP---VSV---HC---------WT-------SFAHTRQIAVACLLRSEK RRAQDSRVDSAYRKFMEEYLTLGHMELVNSSHRKDNTFYFTHHPV-------YSAEVGPE GKF-RVVFNGSF----GK---ISLNDVLLTGRKLQ--SDVTIIISMWR---FSKI--VFT ADIVKEFRQILIHPD--DVDWQR-----I------VWRSD---V-SK---------PI-E DYRLLTVTYGTRSAPYLSIRT-LLQL------------A----SEG-SLEF--P-LAAQV L-RHN--MYVDDA-FVGAD-N---ESEAIEIRNQLI-KL-LSSA-------GMELG-KWA SNCS-AI-LEDIRAEKQKEFAVEW------------------------------------ -DEAI-----------------SA--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TP QRVFAYTGLDYAGPFP-------------------------------------------- ----------------------------ILFS--KGRG---AKST-----KG-YIA---I -FVCMV--VRAIHIEVVSDLSTAAF-----LAAFRRF-TARR-GLCRMVFSDNGTNFKGA ATEID-K-------LFQRASSV-SQ--------------------EVA---AALAKDGIV ----WSFIPPRAPHFGGLWESAVRSFKHHFKRVIG--D-----TPL----TFEEM----- --STI-----AAQIEACLNSRP--------LCP------------L-------------- ----------------------SS------------------------------------ ----------- >R795/1-553 ---PTRRNVFSFIAKLFDPLGIIAPIIAWAKIMMQR-LWIA-T----------K------ -EWDD-P-IPV--DLADQWELFKKQLYLVK---E-MRIP--RYV--M------------- --LL-D-HT--NV-QIHS-FADASEV-AYG-ACVYLR--VTNR-EG------TVKI-G-- LLAA---------------------------KSKV-APL-------K------------- ---K----------------------------LSLPRLELCAAV-LGA-KLWKTACIA-- -L-K----Q-Q-I---TES---YF---------WS------------------------- --------------------------------------YLPHHPV-------VKLS-SAS TKV-RPVFDGSAKTS-TG---FALNDCLLNGPVLQ--DTLFDLIVRFR---SYAI--ALI ADIEKMYLQVKVHEE--HTPLQR-----I------LWRSS---Q-QE---------EI-K HFELQRVTFGLTSSSFLATRV-LFQL------------A----ADE-GERF--P-LGKRA L-QES--FYVDDY-IGGAN-S---DAEAVQLVSELR-QL-LEKG-------GFHLR-KWN SNNK-MV-LRNLSPEEKDKCK--L-V-SIG---------------------------P-- -EDQV-----------------KT--LG-------------------------------- -----VYW---------------------------------------------------- ----------------------------------------------------------TP ARPFLTTGIDFCGPVY-------------------------------------------- ----------------------------LKPV--HRRA---TSQ------KA-YIA---V -FVCFC--TKAVHLELVEDMTTSAF-----LAAFRRF-ISRR-GYPSDVYTDNGLNFRGA QRELN-D-------LFRLLSDD-SF------------------QATTR---EETMKCGIT ----WHFIPPRAPNFGGLWEAAVKSTKKTLTKLFG--S-----QRL----SFADM----- --STV-----LTQIEAQLNSRP--------LTP------------L-------------- ----------------------SE--------DPE--E-------L-------------- ----------- >R799/1-548 ---TTKRDILRGISTVFDPMGFFAPLTIAAKILNQE-LWKE-K----------F------ -DWDD-P-LPQ--KFRERFSKIAADIDNYH---P--VVP--RCY--L------------- -ECHNDLQ------NLHL-FVDASPH-AFG-AVAYFC---------------NLDRVA-- FVLS---------------------------KSRV-APL--SIGKKP------------- --------------------------------PTLPQLELMAAL-IGS-TLANTIVKA-- -L--------KPL---GISLTVTM---------WS------------------------- ------------------------------D-----CHYIPHFAI-------EKE--SAT TPL-RIVYDCSCKTS-AG--V-SLNDCLETGPPLQ--NDMLEILLRFR---VHRV--GIS ADIEKAFHKVILHES--DRDFFR-----F------LWTSN---I-SN------PDADL-E VYRFKVIPFGASCSPFILLSV-IKHH------------L------HSL-PS--L-TA-VD M-DLN--IYVDNL-ISGCD-S---TKEAVDYYAVSN-SI-LNKA-------GLNLQ-SWS SNDQ-AI-NVRAVEDGVADP---------------------------------------- ST-SS-----------------KI--LG-------------------------------- -----LNW---------------------------------------------------- ----------------------------------------------------------SD APPFTVVGVDYTGAYT-------------------------------------------- ----------------------------IRG--VS-PK---NDQ------KA-YIC---L -FTCAS--TRAIHLELVEDLSAQSF-----LLAFRRF-VSHH-SLPSMVISDNATNFECG ADFIT-K-------IFRS--------------------------PEVA---NYLTSQQVD ----WQFIPKRAPWYGGFWERLIGVTKIALSKMLG--R-----TKP----TFDEL----- --RTL-----VAEAEFVLNDRP--------IEK------------M-------------- ----------------------SA--------DSQ--T-------EEALTPSHL------ ----------- >R801/1-548 ---PTKREVMSFIASIYDPIGLINPVVVTCKNLFQR-ICVS-K----------L------ -GWNE-N-LYG--DLLSTWNLILSDFKSVF---Q-IAVP--RWYMSP------------- -GLGNINN--VKF-ELHG-FSDASVK-SFG-CCVYLR---FFNANF------S-RA-S-- LIAS---------------------------KSRV-APL--G-K---------------- --------------------------------NTMPRLELSATL-LLA-KLLASIYDQ-- -L------I-SIYNI-SNI---VY---------WT------------------------- --------------------------------------YLPHRPV-------CRK-DKTT TKV-RIVFDASST---LS--GPSLNDCINAGPSLA--TPLFFILLRFR---ANKY--AFI ADIEKAFLQIALDKN--DRNYLR-----L------IWFDD---I-YNINNSNLFSSAL-A TYRICRVPFGVTSSPFLLNAT-LIYH------------A----ERYCLNDN--N-IS-SK L-LQS--LHIDDL-ISSCV-T---IEEGVLFFNKCK-DI-LKEG-------GFNLR-KFE SNSS-AF-EKQINGDNYERQ---------------------------------------- -TNT------------------RV--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------NS DFAFKCIALDYAGPLY-------------------------------------------- ----------------------------IKDIYGD--C---TLN------KA-WIF---L -FTCCS--SRSILLDLVADCSSRSC-----IMGIRRF-IGRR-GVPEIIYSDNGSQFVS- --------------------------------------------TETQ---YFAANHSIK ----WKFNAPSAPWWGGMFERLVRMTKRCLKKALK--N-----SKS----SYEEV----- --RTL-----LSEIEMVLNNRP--------LTY------------L-------------- ----------------------YN--------NQG--D-------EA-LTPNHL------ ----------- >R802/1-521 -------------------LGM-----------HR------------------------- ----------S--RMNRKYGLSGKTL-FPR---E-LKVP--RSL--V------------- ----THREVIKSI-ELHS-FGDASAQ-GVS-ACVYAV--V-TQ-ES------GVNQ-G-- LVAA---------------------------KARL-AKQ--G------------------ --------------------------------LTIPRLELVAGH-MAV-NLINNVKGT-- -L------DGLPV---SGL---HC---------WL------------------------- ------------------------------GPSIGREFYIPHKPV-------LRT-QAES SKL-RIVYDASAKEH-RE--APSLNDCLHKGPPLQ--NKIWDVLVRGR---FNTV--AIT GDLQKAFLQVRVREC--DRDAMR-----F------HWRTN-------EH------SPV-Q TLRFTRALFGLAPSPFLLGGV-IEAH------------L----DTWEDKEP--E-VV-SR I-RKE--LYVDDL-ISGAS-T---VKEARELKEKAT-QI-FKDA-------GFKLH-KWH SNAK-EL-ESEGPASEDSTYA--------------------------------------- KQELGVPVNEEC----------SL--LG-------------------------------- -----LGW---------------------------------------------------- ----------------------------------------------------------QG TSAYQVIGVDFAGPIK-------------------------------------------- ----------------------------YRV--A--RQ---KEE------KA-YVL---L -YTCSL--TRGIYLDLLPSLETPDC-----LHSLKQF-IARR-GRPDRIYSDNGRTFVGA EKWIK-Q-------VMQD--------------------------ERLQ---DSLSVNQIR ----WQFNLSRAPWWGGQFERMIGLVKASLHKSIG--H-----GML----YWKEL----- --QEI-----LLDMEITLNNRP--------PSY------------I-------------- ----------------------ED--------DVQ--L-------PL-LTPHSL------ ----------- >R803/1-566 ----TKRVILSEIAKIFDPVGLVGPVGLHAKWIMQE-CWKE-K----------V------ -SWDE-S-VPQ--SLFTLWMDFASQLSSLS---S-VSAP--RHV--V------------- --CV-N-PS--RI-EIHG-FSDASKK-GYG-ACLYAR--STDK-DE------KITV-R-- LICS---------------------------KSRV-APL-------K------------- ---E----------------------------QTIPRLELCGAV-ILV-RLLLETLPA-- -L-E----F-S-I---DRI---VL---------WS------------------------- ---------------------------------------LPFLIV-------VKIL-SLT TKF-RVVFDASAKSS-LG---VSLNDLLHVGPTIQ--DKLYVHLVRFR---SHRY--VLT ADIEKMYRQILIHPE--DRRYQR-----I------FWYRD---G-KL------------Q VYELNTVTFGVSSAPYLAIRT-IHRL------------A----DDE-SAQY--P-RAAEI L-KRD--MYVDDL-LTGSD-S---LDEIMKARDEII-TV-LKHG-------GFNIR-QWA SNHN-HA-LDNLDEKVLSLAP------DGE------------------------------ -DAVL-----------------KT--LG-------------------------------- -----VSWASKRDELAIVV----------------------------------------- ----------------------------------------------------------TE SHVFSHVGVDFFGPLS-------------------------------------------- ----------------------------IKEK--KRYN---RTAL-----KA-YGC---V -FVCMA--TKAVTIEITSDLTTEGF-----LGAFARF-VGRR-GIPQHVYSDNGTNFVGA NNQLR-E-------LFALLNSE-EF------------------KSKVN---AKALSLDIQ ----WHFNPPLSPHFGGLWEAAVKSFKHHLKRVVG--G-----QLL----TFEEL----- --YTL-----VIEIEAILNSRP--------LWS------------I-------------- ----------------------SA--------DPN--D-------PIALTPAHI------ ----------- >R809/1-599 -----RRGILSVVNSIYDPLGFLAPLILPVKLLLRD-LCKQ-G----------Y------ -GWDD-E-IDD--KRADQWVKWLEDLSQIS---N-VKFK--RCL--K------------- -PEKFGI--TAEA-QLHH-FSDASES-AYG-TATYLV--LTNE-QN------QKYC-S-- LLMG---------------------------KSRV-SPL--K-Q---------------- --------------------------------ITIPRLELTAAT-IAV-KMDKILRQE-- -L------Q-MPL---QPS---IF---------WT------------------------- ---------------N---------------RNDNKVWYIPHHGV-------YHPK-K-- NKI-RVVFDCTAS-F-QG---MSLNSQLLQGPNLT--NTLIGVLTRFR---EEPI--AVM ADVESMFYQVKVPEE--DTDLLR-----F------LWWPD---GNLN---------APIE EYRMTVHLFGATSSPSCASYA-LRKT------------A----EDR-KHVA--SQKAVDT V-LNN--FYVDDC-LKSVS-N---EQEAINLVKEIQ-DL-CLEG-------GFRLT-KWV SNNR-KV-LLSI-------PEDQRASGVKDLD-----------------------LDQDS -LPIE-----------------RA--LG-------------------------------- -----MQWCTDDDTFTYHIKVQEKPSSRRGILSVVNSIYDPLGFLAPLI----------- ----------------------------------------------------------PD KPPFTNVGVDYFGPFE-------------------------------------------- ----------------------------VK--RG-R-----S-TV-----KR-YGV---L -FTCLT--IRAVHIEVADSLDTDSC-----INALRRF-ISRR-GQVAVMRSDNGTNFVGA ERELR-E-------ALKNLNHI-T----------------------IE---QAMLQKNIK ----WIFNSPAASHQGGVWERQIRTVRRILNALLK--E---Q--SI----SDDSL----- --HTI-----MCEVESIINNRP--------ITT------------T-------------- ----------------------SE-------------D--------PNDL---------- ----------- >R811/1-635 ----TKRKILSISARVFDPIGFLSPTVLLLKIIYQK-LWEK-E----------L------ -GWDD-E-APL--DIQQSWKLVMSGLKEFE---N-LQIP--R-W--I------------- -GYSKHK--ITSA-ELHV-FGDASES-AYG-AVAYAR--LQKE-NE------EPYV-I-- LLVS----------------------------TRV-APLPKK-K---------------- --------------------------------VTLPRLELLSSL-LAI-RLGEKVRTS-- -L------H-IE----LRT----------------------------------------- --------------------------------------YLPHHPV-------YRM-DKNT TKI-RPVFDGAAKSK-FG---PSLNDVVETGPNLN--PDLLSVLMRFR---MYRI--AWI ADIEKAFLNVALQPE--DSKAVR-----F------LWPKE---P-------AIPGSPL-I AYKWKRVPFGLSSSPFLLRVT-VNKH------------LLSV---QSRFPE--T-VE--Q L-REQ--LYVDDY-LGGAD-D---EPAAIKRVEETD-EI-FKEA-------KLNMR-SWA TNEE-TT-RQLLEEKGLCN----------------------------------------- ----------------------KV--VG-------------------------------- -----ILSPTLDGQQKVLGIRWDTESDTFKFDPSTV------------------------ ----------------------------------------------------------RQ AQSFHITGVDFAGPLYYKPPQVRKRRKKTTEVQPIIADPAVVEEDSEEEPLAVEEAPN-- --PNPDPAV----PADEDIELQELLFDDLSPQVVT-SS---KHL------KS-YVC---L -FTCAV--TRAVHLELTKDMTVRSF-----LLAFRRF-SARR-GPVSVMYSDNAQTFHCV ARHLK-V-------LRSD--------------------------PSIH---DLLAMRGTL ----WIFSASLAPWWGGFWERMVRSVKDLLRRSNG--R-----SCL----EYDEL----- --EVS-----LIEIESVINARP--------LNY------------V-------------- ----------------------GE--------GID--D-------PLPITPNQF------ ----------- >R813/1-548 ----TKRNILK-AASFFDPLGFLTPITSRVKTIFQL-ICRD-K----------S------ -GWDE-I-VTE--AIELALTEFLKDLELLS---F-VRIP--RFV--F------------- -ER-VNE-SSKRV-QLHG-FCDSSKL-IYC-AVIYLV--VETS--L------GVNR-K-- FLVS---------------------------KSRV-SPL--K-E---------------- --------------------------------LSIPRLELLGCV-LLS-RLLEEVLRV-- -L------K-GRVHF-EDV---SC---------WC------------------------- ------------------------------H-------YLPHRPV-------IRR-DKDT TKI-RAVFDASCS---TT--GPSLNDCLYSGPNLL--SKIFDILLKFR---FNAI--GII ADIKQAFLNIEISPE--HRDYLR-----F------LWYER---I-SDKE------AKL-I VYRFLRVVFGLTSSPFLLNAT-LKHH------------L----NKYIKHDE--K-FI-ER L-IDD--LYVDDITASGCE-T---ISEGKMLYKKSK-CI-FLDA-------GFELR-KWI TNDH-EL-QNYFNKKETNQSE--------------------------------------- NSKCNL-----------KVDELKY--FE-------------------------------- -----SEI---------------------------------------------------- ----------------------------------------------------------NN LYSFQATGLDYAGPLF-------------------------------------------- ----------------------------VKTVNKD--A----AC------KV-YVL---L -LTCAS--SRAIHLELTPDMKIPAF-----IRAFKRF-AARR-GFPDLIISDNFKTFIS- --------------------------------------------KEVK---NFMMKNDVQ ----QKFILPASPWWGGFYERLVRSVKITMKKTIG--K-----SLL----SYEEL----- --ETI-----LCEIESVINSRP--------LFY------------M-------------- ----------------------SE--------DDT--E-------EA-LTPYHL------ ----------- >R814/1-526 ----TKRGVLKKLAGLYDPLGWASPYVVRAKVMLQR-TWSR-G----------I------ -DWDE-L-LPS--DLRLEWSKWEAEMVALK---S-FVVP--RYI--Y------------- ----RQPSKLRKK-QLVV-FCDASEE-ACA-AVAYVR--ATST-VG------EVTC-H-- LVIA---------------------------KTRL-MPL--K-P---------------- --------------------------------ISIPRGELMACQ-LAV-RLAKAACVQ-- -L------S-LSM---REV---IY---------LS------------------------- ---------------E---------------QWL-----LPHHPV-------LSPH-K-- -PLPRVVFDSAAV-H-DG---ICLNDCLEAGPSLH--NDLPGVLMRFR---ERPV--ALA GDVSDMFCHVRLRTE--DRKYHR-----Y------LWRDL---E-TD---------KPPD VYEMNCLVFGDKSSPCEANFA-VQRT------------A----EDN-KEQW--PDAA-AV V-KRD--IFVDDL-YTSCE-D---VGEAVKLREDVT-AL-MAEG-------GFPMR-KWM SSSA-EV----------------------------------------------------- --------------------------LA-------------------------------- -----TVP---------------------------------------------------- ----------------------------------------------------------GV STPFKHVGLDYAGPFQ-------------------------------------------- ----------------------------VR--VG-R-----NRVE-----KR-YVC---L -FTCLH--MRAVHLETAHSLDTDSF-----IMALRRF-RARR-GNPVRIMSDNGSNFVGA ERELR-D-------ALQELSQE-R----------------------IA---DELSVHGVK ----WDFNPPDGPWFGGAWEALVKSTKRTMRVMLG--N-----VLT----VDEVF----- --RTV-----LAEAESILNSRP--------LVY--------------------------- ----------------GGSVSSPT-------------DV--------------------- ----------- >R817/1-610 ----TKRKILSISARIFDPIGFLSPTVLLLKIIYQK-LWEK-E----------I------ -GWDQ-A-APT--DIQKSWKIVMTGLTDFT---E-LQIP--R-W--I------------- -GLSE-K--VTSH-EIHV-FGDASEA-AYG-AVAYAR--FQRG-QE------DPCI-V-- LLAS---------------------------KTRV-APLPKK-K---------------- --------------------------------VTLPRLELLSSL-LAV-RLGEVVKNA-- -M------Q-IQY---WRT---IY---------WS------------------------- --------------------------------------YLPHHPV-------FRG-DKST TKI-RPVFDGAAKTK-FG---PSLNDVLETGPNLN--PDLLSVLIRFR---KYEI--AWI ADIEKAFLNIALQPE--DAEAIR-----F------LWPRD---P-------AVAGSPL-I AYKWKRVPFGLSSSPFLLRIT-INKH------------FKSL---KSRFPE--T-IQ--Q L-EEN--LYVDDY-LGGAS-N---LSIAKKRVDETD-EI-FSDA-------QLNMR-SWA TNNE-DL-KQHLKEKGLSI----------------------------------------- ----------------------KV--VG-------------------------------- -----LLS---------------------------------------------------- ----------------------------------------------------------KH AQSFHVAGVDFAGPLLYKPAQRRKKRKAPSGVQ----DPTPADDPTEEQ---IEEPPTEG DAPIEAPIVGEEDSIEEDVEIQDIL---TTTTKAK-KT---NHL------KC-YVC---L -FTCAV--TRAVHLEILPDMTARSF-----LLAFRKF-AARR-EPVSVMYSDNAQTFRCV ERFLR-T-------IHAD--------------------------PVIQ---DFLASRKTL ----WIFSASLAPWWGGFWERMVRSVKDLLRRSNG--R-----ACL----DYMEL----- --EAS-----LAEIESVINARP--------LSY------------I-------------- ----------------------GE--------GAD--D-------PLPITPNQF------ ----------- >R819/1-575 ---PTKRVLLKIIMSIFDPLGFLTPFTIEAKLILQG-VWNS-K----------I------ -GWDE-C-IQD--TEFDQWKRWLQKLD-IK---L-LHIP--RSY---------------- ---RSKNCQVKSA-ELHI-FCDASSK-AYA-AVAYWRICLKDD---------SYHV-S-- LIMA---------------------------KSRV-APMKET-T---------------- --------------------------------VTIPRLELQAAV-LAI-RVANIIAKE-- -H------D-FQI---SRR---VF---------WS------------------------- ---------------K---------------PSGSRIWYLPHFGV-------SNIN-K-P GKV-RLVFDAAVA-T-SS---VSFNKLLLSGPDLL--KSLLGVLMRFR----FHY--AIK DDLRDMFLKINIQEA--DRDAQR-----F------LWRGC---D-RT---------IEPD KYVMSSVLFGAKSSPFTALFI-KNKN------------A----SLC-SSTY--P-AAAKS I-IEN--SYIDDF-LESCE-T---REEASSRVQQVV-EI-NKHA-------NWEMH-GWA SNDA-SV-LSNS--------NINSNDKQPINF-----------------------ETKDN I---E-----------------EI--LG-------------------------------- -----LRWVNSTDELIFKI----------------------------------------- ----------------------------------------------------------YR LRPFSHCGIDYFGPLN-------------------------------------------- ----------------------------VK--VGYR-----R-RE-----KR-WGV---L -FTCMS--TRAVHIELAQTLSTSSA-----ILALKRF-TGRR-GTPFVIYSDNGTNFIGI NNEIK-K-------ALKDLDRK-K----------------------LN---EFAAKKQIV ----WKFNPPTASHMGGAWERLIRSVKNALNVVFK--D-----QAY----CEELL----- --QTI-----LIEIEHCINSRP--------LTH------------V-------------- ----------------------SI-------------DPRDKEALTPNHF---------- ----------- >R821/1-530 ----TKRNILRLAASIYDPLGLISPITTRVKTIFQI-LCKD-K----------L------ -EWDE-E-IPD--SIKLLWESFVLQLSKIH---I-C-FP--RYV--I------------- -KE-IKE-DIISI-ELHA-FSDSSIQ-AYA-SVIYIR--V-IS-RT------SIKT-C-- LLTS---------------------------KTKV-APL--K-T---------------- --------------------------------LSIPRLELLGCH-LSS-KLMKQVQHS-- -I------C-DKVVI-SKI---VA---------WS------------------------- ------------------------------TKPPGSVCYLPHHPV-------IRE-EKET TKV-RAVFDASCA---KN--SPSLNDILYPGPNLL--SKIFNI-LRFR---VNVI--GIT SDIKQAFLNIEIVPE--HRDFLR-----L------LWFSN---L-S-RD------DQL-V IYRFTRVVFGLTSSPFILNGT-MQHH------------L----NKYLSSYP--E-FI-KK I-IPD--WYVDDL-VSGCD-S---LNDGVQFYHTAK-DI-MLKG-------GLELR-KWT TNNI-EL-QNHINKCE-------------------------------------------- ---------------------------G-------------------------------- -----VNL---------------------------------------------------- ----------------------------------------------------------QS TRSFKYTGLDYAGPLF-------------------------------------------- ----------------------------IKENNDK--A---NIL------KV-YVL---L -LTCAT--TRAIHLELTNDLQTPSF-----LRALRRF-ISRR-GSPELLISDNAKTFKA- --------------------------------------------KPVR---EFMLNRGIR ----Q-FILPASPWWGGFYERLVRSVKLCLKKMLH--K-----EIV----TYBEL----- --SSV-----LCEVE-YINQRP--------LY---------------------------- ----------------------VS--------DDE--L-------ES-LTPFHL------ ----------- >R822/1-520 ------------------PCG-------KAKLIIQE-LWRC-K----------I------ -DWDE-P-IPE--ELRSIWKSWKDGLKTPL---M-IQVP--RWY---------------- ---GFHLRDAQDI-QLHV-FSFASEV-AYG-AVTYLR--AAV--GD------QVVV-S-- FVLG---------------------------KTRL-APV--R-T---------------- --------------------------------LTIPRLELQAAV-VGA-RLRKKVINE-- -I------D-LPI---NAV---HL---------WS------------------------- ---------------A---------------IEGPRTWYLPHHGV-------QNPS-K-P GKL-RVVFDAAAK-Y-NN---VSLNDCLLTGPDLL--NDLVGVLIRFR---CNKV--GIM GDIEKMFHQVKVREA--DQDSLR-----F------LW--R---NLEE---------RIPD VYRMAAHVFGAIDSPCSACYA-LRKT------------A----EDQ-AGLF--PDDVLDT I-KRN--FYMDDV-LTSRP-S---EDEAAAVANQLI-EA-VAAG-------GFRLT-KWV SNSR-NV-LRSL-------PSDEVSCDVVNLD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MC EPAFSSTGVDYFGPMT-------------------------------------------- ----------------------------VK--RG-R-----V-TE-----KR-WGC---L -FTCMT--TRAVHVELAGDLSTDAF-----ILALRRF-RARR-GNPRLMQSDNGSNFVGA QRELA-E-------ALARIDQE-R----------------------VT---DELSKESVT ----WSFNPPAAPHMGGVFESMVKQVKRALKVVIG--D---R--VL----YEDVL----- --HTA-----LVETEAVLNSRP--------LTP------------V-------------- ----------------------SD-------------DPDD--------F---------- ----------- >R825/1-545 ----TYRTILSDVCGLYDPLGFWTPVTLTARILLQD-ICRI-K----------P------ -EWDE-I-LPE--PLLERWRIWVSNLHHLE---S-VAVP--RCL--Q------------- -PF---P--PTSV-QLHI-FVDASEL-GFG-AVAYLL--LQN--KK------TSTT-V-- FVMS---------------------------KSRV-API--H-H---------------- --------------------------------LTIPRLELSAAL-LGA-RLARTIKNE-- -L------R-LKI---DGE---VF---------WS------------------------- -------------------------------------WYVPHHAV-------FHPD-K-P GKC-RVVFDGAST-F-RG---ISLNSCLLTGPDLL--TSLIGVLLRLR---ERPI--AIS GDIKGMFHQVRVRSV--DKHVLR-----F------LWRPP----HTA---------GPPD VYEMQVQIFGAASSPTVCSYV-LRRA------------A----ADN-EEEF--P-GLVEK V-ATN--CYMDNY-MDSFG-T---EEEAIEFRNKFQ-DG-LKKG-------GFHWT-QWM STSR-KV-LQSV-------PEDLRSDPKLNLN-----------------------L--DA -LPAE-----------------KT--LG-------------------------------- -----VTL---------------------------------------------------- ----------------------------------------------------------DD RPAFSNTGIDYFGPIL-------------------------------------------- ----------------------------TT--VG-R-----R-RE-----KR-WGI---I -FTCLV--SRAVHFEMAYFLDTSSF-----LLAFWRF-ARRR-IRPDVIYSDNGTNLTSG EKELK-A-------GLDRLNQT-A----------------------IA---NELGAQNIE ----WIFSPPSAPHFGGVWESLIKSAKDSLSFILQ--D-----HTF----PDEVL----- --LSA-----LIEVESIMNDRP--------IGR------------C-------------- ----------------------ST-------------DPNDF------------------ ----------- >R827/1-546 ---ATKRNVLSVLAGMFDPLGIVSPVTVAARILFQT-LCRMTE----------L------ -TWDE-E-LTG--EVRKEWEAWVKDLGNLM---S-VEVP--RCV--L------------- --DTSNRKV-----QIHG-FADASRK-AYC-AVVYL---VYDV-GG------ERQV-R-- LLCS---------------------------KTRV-APL--K-E---------------- --------------------------------MTIPRLELMAAL-ILA-RLVSHVKEA-- -LGT----L-IEV---ERE---VY---------WS------------------------- --------------------------------------------------------VATS TPV-RVIYDASAKTG-KK--GVSLNDCLHVGPSLN--PLLFNVLLRFR---LHRV--ALI ADIEKAFLNIEVDPG--DRDCLR-----F------LFPED---P-RRED------SVI-K VYRFCRVVFGLNASPFLLNGT-LRHH------------L----VKFKEIDP--E-FV-EM L-VNS--FYVDDL-VTGSN-T---PEEAYELYVKSK-SR-LAEG-------GFNLR-KWQ TNDS-EL-RGR-DVSEGRCMP--------------------------------------- GSQEGVARGKTSQGVASDCDIQKV--LG-------------------------------- -----LPW---------------------------------------------------- ----------------------------------------------------------TQ AEPFSKVGVDFAGPLY-------------------------------------------- ----------------------------YKS--S--TG---MMQ------KA-YVA---L -FSCCV--TRALYLDLVVDLEACTF-----RRCLRRF-AARK-GAPTLIVSDNAKTFKAA AKALR-E-------LYDH--------------------------PEVQ---AYLEVNRVS ----WQFNLEKAPWWGGFYERMVGSVKRCLRKTLG--E-----ARL----TYDEFWWRSR AHTTG-----RLHMCTMRSER--------------------------------------- ------------------------------------------------------------ ----------- >R829/1-519 ----TKRDVLKGNGAFYDPLGFYTPLGTSSKILIQD-ICIA-D----------L------ -KIDE-E-LSA--DHLKRWKEIVDSINGAVDQQL-MSLP--RSY--F------------- -------GTVDAVQELHV-FCDASRR-AYG-AVAYLC-------YG-----------S-- --GA---------------------------KDLL------------------------- --------------------------------RSKPHLCRKHAL-LLS-RIASGKERERS QF------Q-------KRN--------------WL------------------------- ------------------------------------------------------E--SAT TPI-RIVYNCSCKGW-NG--V-SFNDCVEAVAPLH--NDQTQILINFR---SHAI--GIV ADVEKAFHHINLHKA--DRDFLR-----W------FWLED---P-TN------PESPL-A VYRFRVVPFGAKSSPFILNAV-MMHH------------L------KKS-TS--E-IA-AD M-LQS--VFVDNI-ITGCE-S---PSAALNYFTEAN-RI-MNEA-------HLPLQ-AWG FSDG-AV-EKSLAEGGSTDP---------------------------------------- SR-LS-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------QE NYPFAVTGVDYTGAIQ-------------------------------------------- ----------------------------VTS-----KG---ERI------SV-YIL---L -FTCGV--TCAIHLEVVEDMTAGSF-----INALKWF-TGHH-PIPRLIYSDNASTFVNA SNHLL-E-------LFNH--------------------------RKVQ---EELAAIRIL ----WKFIPKAASWYGGWWERLIALTKTALLKMVG--R-----TIL----SFTQL----- --QTV-----TTQIEAILNDRS--------LTK------------I-------------- ----------------------ST--------DEN--C-------IQPLTPSHL------ ----------- >R833/1-532 -----KREVLRGISATYDPLGFITPLTIPARMLIQG-IWKL-K----------L------ -DWDD-P-IPF--ELIERWKGIATSIEDSK---T--SFN--RSY--F------------- -KT-GEIK------ELHV-FVDASQL-AYG-AVAYFC---------------NDDSSS-- FVFS---------------------------KSRV-APL--KTEKKL------------- --------------------------------LTIPQTELMAAV-IGT-RVASSILSA-- -L--------LPL---GLKPNCYL---------WS------------------------- -------------------------------------HYIPHFGV-------FKE--SAT TPL-RIVYDFSCKTP-TG--V-SLNDCLEVGPPLQ--NDMLAILLRFR---AHTI--GLT ADIEKAFHQVGLHEQ--DRDFVR-----F------LWLKD---P-YD------SKSDF-- LYRFRVIPFGASSSPFILLSV-IKKH------------L------QNS-SS--L-LA-DD I-NRN--IYVDNL-ISGCE-T---SEEAVSYFSEAN-NV-LKSA-------GLNLQ-SWG SNDD-QL-TVKAKSEGVGDK---------------------------------------- SQ-VT-----------------KV--LG-------------------------------- -----LDW---------------------------------------------------- ----------------------------------------------------------SF SFPFTVTGIDFTGAFT-------------------------------------------- ----------------------------IRGPKEA-PK---VDR------TV-YIL---L -FTCAS--TRAIHLEVVEDMTTLSF-----LDAFGCF-VSHH-SRPAVIMSDNAKTFEKG AKLFQ-K-------IFRD--------------------------PIVT---RRLSDQQIE ----WRFIPKRAPWYGGFWERLIGLAKSALSKILG--R-----TKP----TLSAF----- --RAL-----VADAEVVLNDRP--------LE---------------------------- -------------------------------------------------NPSSS------ ----------- >R835/1-530 ----TKREVLQEVASVFDPLGFLSPVIMTAKILLQD-IWRS-G----------A------ -DWDD-P-LPP--TLLEIWMAWAKELSAIA---S-IKIP--RCF--R------------- -LQEKPI----SY-ELHV-CSDASEV-GFG-ACVYLR--AEYP-NG------HFRL-N-- LLLA---------------------------KARV-APL--R-Q---------------- --------------------------------LSIPRLELQGAV-LGV-RLCDSAIKE-- -L------G-PIA---AQV---IY---------WC------------------------- ---------------S---------------IRKGFTWYLPHHGV-------TNPN-K-P EKV-RVVFNPSAR-Y-KG---TSLIEQLFKGPDLL--TCLIGVLLRFR---QFPV--PIS GDIEKMYHQVLVPKQ--QQSLFR-----F------LWKNP---GDVG----------EPK EYQMTVHVFGAV-SPTSCIYA-LRKT------------A----EDF-GSRF--P-DVADS V-SKN--IYVDNY-LDSTE-T---EEEAIARLRDVS-AL-LKLG-------GFNMV-QWL SSSR-SV-LATV-------D---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TH LPAFTNVGIDLFGPFS-------------------------------------------- ----------------------------VV--IL-R-----R-SV-----KR-YGV---M -FTCLD--TRAVHLEVADSLDMDSF-----INAFSRF-ADRR-GVPQLCYSDNGTNLVAG EQEIN-R-------ALSRWNEA-E----------------------LVQKIEKLKNQPIE ----WRFSPPVAPHFGGSWERLIKSAKTALRGILN--N-----RSV----TEDVL----- --VTA-----IVGAEALLNSRP--------LTH------------V-------------- ----------------------SV-------------NPNDL------------------ ----------- >R837/1-531 -----KREMLAYLMKIYDPLGLAANYTTQAKVIIQE-IWKT-E----------L------ -DWDS-P-VPE--RIMEQWQRWKERIKELE---H-IQIP--RCY--S------------- -VAS-NI---EVT-ELHT-FVDASEK-AFA-AVVYLR--TLTE-KG-------IDV-N-- IVAA---------------------------KTRV-API--K-P---------------- --------------------------------LSIPKLELQAAV-LGV-RLAETVKEE-- -L------R-ITT---DRD---YY---------WS------------------------- -------------------------------------NYIPHFMV-------INPN-KPT PKP-RLVFDAAAK-N-EG---ISLNSTLLSGPDAT--TSIFGVLIRFR---EYPI--ACS GDIKEMFHQIRIRKE--DQVAQR-----F------LFRD----N-PR---------NEPQ VYVMNVMTFGATCSPACAQFV-KNEN------------A----LKY-KDKY--P-TAVEA I-VKN--HYVDDY-LDSFR-T---INDAIKTINEVC-LI-HDRA-------HFFMR-NFV SNCQ-EV-IRSI--------PDDRSSQQEL-L-----------------------HISNK DMNFE-----------------KI--LG-------------------------------- -----QYW---------------------------------------------------- ----------------------------------------------------------VF KKPFTHTGVDYFGPMT-------------------------------------------- ----------------------------VS--IG-R-----R-VE-----KR-WGA---I -FTCMT--TRAIHLEIAKDLSTNSF-----IMCLKNV-QHRR-GKICHIYSDNGTNFVGA NRQIT-E-------LVERC-----------------------------------ATNGIK ----WHFNPPAAPHFGGVWERMVREVKSLLP-N----N---D-NMP-----EEVL----- --RSA-----FIEIEFILNNRP--------LTH------------I-------------- ----------------------PL-------------ET--------------------- ----------- >R839/1-554 ----TKRTILSVASSLFDPLGLVAPIIVTAKIILQE-LWIV-K----------L------ -QWDE-S-VPQ--NLYLTWKSFAASLTSLE---S-LKIP--RFC--M------------- --QPNT-K---EL-QLHG-FCDASIR-AYG-CCIYAR--TVAA-DG------EVQV-H-- LITS---------------------------KCRG-APT--R-K---------------- --------------------------------LSLPKLELAASH-LLA-QLYVKIKGI-- -F-T----S---K---Q--T--YL---------WS------------------------- -------------------------------------NYIPHHCV-------FKPN-STS TKL-RVVFDASNRTS-SQ---QSLNDLLMVGPTIQ--TDLYTLLLRFR---TYKY--ALT ADVVKMFRQVLVDYR--DRKFQY-----I------LWRDS---T-DK---------PL-R TYSLNTVTYGTASAPYLAIRS-MKYL------------A----DLH-MQTH--K-LGSQA I-NSS--FYVDDF-LCGHD-T---AEGLQQLKAEVI-EV-LGKG-------KFELA-KWH SNHP-DF--VDDSTIKDLNLE--------------------------------------- DGSVT-----------------ST--LG-------------------------------- -----LAWNQRLDGLL--F----------------------------------------- ----------------------------------------------------------TP SRPFAHCGVDFCGPVN-------------------------------------------- ----------------------------VYLR--IQGK---APR------KA-YIA---I -FVCFA--TKALHIEVVSDLSTDAF-----LPALRRM-IARR-GLPVDIFCDNATNFTGA SNQLK-E-------LRTYFFKQ-EN------------------QQSII---SFCTNEFIN ----FRFIPPRAPHFGGLWEAAVKSAKGLMTRSLM--N-----ARC----TFEEL----- --ATI-----TAEVEAILNSTC--------EHC------------L-------------- ----------------------HT--------IKM--N-------S-------------- ----------- >R840/1-520 ---FTRRGVLSTVNSIFDPLGFVSPVTIQGKLIMRE-LNNQ-N----------D------ -DWDA-P-LPK--EMEEKWETWRQSLIDLK---N-LNIP--RCY--T------------- -NISPST--ATQR-ELFI-FSDASTK-AIA-AVAYLR--LTDS-FG------VSQL-G-- FVMG---------------------------KAKL-S----P-E---------------- --------------------------------QTIPRLELCAAV-LAV-ELAEFITSE-- -I------D-MHL---DDI---AY---------FT------------------------- -------------------------------------WYLPLFGV-------YHPK-K-P GNI-RVVFDSSAR-Y-ED---VSLNDVLLSGPDMN--NTLVGVLMRFR---KEAV--AIT ADIEQMFYGFLVRED--DRNFLR-----F------LWFRN---NDPS---------EDIV EYRMRVHVFGNSPSPAVAIYC-LRQS------------V---------KDG--DPDVRSF V-NRD--FYVDDG-LKSLP-T---EKAAIDLLKNTQ-RI-LAGS-------NLRLH-KIA SNST-EV-LKA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SM DPPFTNVGLDVFGPWD-------------------------------------------- ----------------------------VV--AR-RTRGGHA-QS-----KR-WAV---I -FTCQS--VRAVHIELIESLDTSSF-----INALRRF-LAIR-GPVKLIRSDRGTNFVGA CRELN-I-------LSN-IDKT-S----------------------VE---KFLLDQSCV ----WQFNPAHASHMGGSWERMIGLARRILDAMLQ--QL--GPSAL----THEML----- --STL-----MAEVTAIINARP--------L--------------V-------------- ----------------------PV-------------SS--------------------- ----------- >R842/1-558 ---YTKREVLSQIAKLFDPAGWLSPFVVRAKIFMQK-IWLR-E----------L------ -GWDQ-P-LPR--DLATQWREFLEGYPALK---E-IRIP--RWV--R------------- -FHPAA-----KL-QYHA-FCDASQD-AYG-AAIFVR--IETK-EG------C-CT-H-- LLTS---------------------------KTRV-APV-------R------------- ---S----------------------------ISIPRLELCGAV-LLT-ELAALVISE-- -M------P-PHV---YET---FY---------WT------------------------- -------------------------------------FYLPHHAV-------FKPD-STT TKV-RVVFNASNPSS-NG---NSLNDILHAGPVLQ--SDLTIQILKWR---FFKY--VFN ADITKMYRQIRVNST--HKRFQR-----I------LFR-N---K-DG---------EL-C DYELDTVTFGVNCAPFLAIRV-LQQL------------A----QDI-RGQY--P-LASDN I-SNF--MYVDDV-LAGTH-N---KQSAVLAIEELR-LA-LESA-------GFPLR-KWT SNER-KL-LQEVPKEHLISAD----FLELE------------------------------ EASTA-----------------KT--LG-------------------------------- -----IRWQATSDSFFFI----------------PMVI---------------------- ----------------------------------------------------------TF SRPFTHTGVDFAGPFD-------------------------------------------- ----------------------------VKSY--VGRA---CKIT-----KG-YVC---V -FVCFT--TRAIHLEATSDLTTEKF-----LAAFSRF-FARR-GCPQHVYSDNGKTFVGA STSLSKD-------FIEAT------------------------RTSVL---SQHSLQNVS ----WHFNPPGAPHMGGLWEAGVKSFKSHFYKYTA--A-----GKY----TFEEL----- --TTL-----LAKIEACLSSRP--------ISP------------M-------------- ----------------------SE------------------------------------ ----------- >R843/1-521 ----TKRLLLSWIARIFDPLGFLAAFVVRGKMIMQS-IWIT-G----------A------ -DWDE-C-LPL--NIDQEARLWVNEAREIV---S-MRVP--RNL--L------------- -ESESDD--WT----IHV-FSDASEK-AYG-SVAYLR--R-QS-SG------EIQC-K-- FIAA---------------------------KSKV-APV--K-T---------------- --------------------------------VNIPRLELLGAC-LGL-KLAKKIVKP-- -I------G-CNI---NEV---CF---------WT------------------------- -----------------------------------EGWILPHFPV-------IKRD-RET TKI-RIVFDAAAK-V-EG---RCLNDNIETGPKLY--NDLFDVLIRFR---KNKV--AIV CDIAEMFLQIGIIKK--DRKYLR-----F------LW------K-KD---------NQLK FYEFNRLVFGLNAAPYLAQLV-AQEN------------A----RKF-KEKY--P-RAVET I-AES--TYMDDS-LDSVG-T---EKEASLLKAQLE-EI-WNKA-------GMRTQ-KWM SNST-KV-LE--------------------NV-----------------------PI--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP LQAFARIAVDFAGPFE-------------------------------------------- ----------------------------TIQGRG-K-----T-RQ-----KR-YMC---L -FTCLQ--TRAVHLEVAYALDTDAF-----IRAFIRF-MGRR-GKPLMILSDNGTNFVGA TNEVQ-E-------IKVD--SY-R----------------------FN---KFMSGNDIR ----WIFNPPLAPHFGGVFEALIKSAKKALQVIVG--S-----ADL----SDEEL----- --NSV-----FIKVESLLNARP--------LTT--------------------------- ----------------------QC--------SDSKEDL--------------------- ----------- >R844/1-549 ----TRRGLLSVVSSVYDPLGYASPFALRGKLILQE-LTRK-K----------L------ -NWDE-P-IPD--SDAKKWKAWIEELPQME---G-VEVS--RCV--K------------- -PHDFGR--VTDY-EIHN-FSDASEV-AYG-AVSYLV--MKNE-EG------EVHS-S-- IIMA---------------------------KSRL-APV--K-T---------------- --------------------------------VTIPRLELMAAT-LAV-NMDVVIRGE-- -L------Y-RSV---KKS---YF---------WT------------------------- ---------------Q---------------PPNGTCWYLPHHPV-------INPK-K-P DKL-RIVFDCAAK-C-LG---VGLNDVVMQGPDLT--NKLTGVLLRFR---RAPI--AIM ADVEAMFRQVTVHPD--ERDVLR-----F------LWWPD---GRVD---------EDPK TYRMCVHLFGGTWSPSCCSFA-MRQT------------A----KDY-GDQC--NTQAPRV V-EMN--FYVDDC-LVSVE-E---EDEAIRLASELR-TL-LQKG-------GFRLA-KWM SSNT-RV-LQTI-------PVQDRAKQVVGLD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AD EPAFTHVGMDYFGPYE-------------------------------------------- ----------------------------IK--CG-R-----S-VR-----KR-YGV---I -FTCMT--TRAIHIEVANSLDTSSC-----IDAIRRM-MSRR-GPIKRLVSDNGTNLVGA KAELR-K-------ALSDWNVD-E----------------------IS---NFTANHSID ----WSFNPPGASHHGGVWERQIRTIRKVLHALLN--E---Q--YLRTCQSEEQL----- --HTL-----MCEVEAIINSRP--------LTR------------V-------------- ----------------------SD-------------D--------PGDL---------- ----------- >R855/1-560 ---PTMREVLSFVMSVYDPLGLISHVTIAGRILMRE-LHVI-T----------K------ -DWDS-T-IPD--ELQEKWEECLRVVKSAE---K-IRIP--RQL--V------------- -ITL--N---DPL-ELHT-FVDASEN-AFA-ACVYARTVTKEG-TV-------FIN---- LVAG---------------------------KARV-API--N-P---------------- --------------------------------LSIPRLELQAAV-LGV-RLTESIRKE-- -L------R-LFV---KHI---TY---------WS------------------------- -------------------------------------FYLPHFVV-------VNRN-KPI PKP-RLVFDAAAE-V-NH---ISLNSQLLSGPDEM--ASLFGVLLRFR---EGNI--CVT GDIQEMFHRVRIREE--DQDSQR-----I------LWRDC---E-N----------RCPD VYVMQVMTFGATCSPACAQVV-KNTN------------A----AAH-AETH--P-LAVDP I-VRQ--HYVDDY-LDSFF-T---MEDAIETVRQVI-EV-HKAA-------DFHIR-NFT SNRG-EL-LKTI--------PQDRVQQKTTSV-----------------------QIEEK GQDYE-----------------KI--LG-------------------------------- -----VHWNPTIDYFGFQV----------------------------------------- ----------------------------------------------------------PY TPPFYNTGVDYFGPIE-------------------------------------------- ----------------------------VQ--VK-R-----S-LE-----KR-WGA---I -FSCMN--TRAVHIELAEKLDTDSF-----MVCLKNF-QNRR-GKICNMYSDNGKNFVGA ERELR-E-------LVTEIDKR-M----------------------GH---ESALKYEIK ----WHFNPPSAPHFGGVWERQIQNIKKGLRHMFS--EWS-H-RHP----TPETL----- --RAT-----LIEIEAMLNSRP--------LTH------------I-------------- ----------------------PL-------------EN--------------------- ----------- >R856/1-517 ----TLRNVYRVLATQYDPIGFLIPFTTRAKVLLQQ-LWVK-E----------R------ -QWDD-PVLPE--GIQKAWAA-ENELPDIT---S-IQLS--RTY--G------------- -PVELDS-TSVKR-ELHV-FCDASEQ-AYG-SVAYLR--IVND-D-------KVLV-S-- FVMA---------------------------RSRV-APR--K-S---------------- --------------------------------ISIPRLELCAAL-TGV-QLANLLERE-- -L------D-LNI---QRT---IL---------WS------------------------- -----------------------------------ESWFVPLHLV-------KHN----- EKY-SLVLNCSYV-F-KG---DSLNTHLLPGPTLG--SSLLGVLLRFR---ENPV--AIS CDIKSMFHQVRLLPS--DKPLVR-----F------LW-RN---MRKE---------EPAD VYEWHVLPFGTTCSPCCATYA-LQKH------------V----RDL-SEN---CEDLKDS I-TKA--FYVDNC-LQSVS-D---IQKGKELVEKLR-AH-LKEG-------GFEIR-QWA SNVL-EV-VEV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LF KPLFWSTGMDCFGPFT-------------------------------------------- ----------------------------VK--TG-R-----K-TG-----KR-WGL---L -FKCQT--TRCVHLELLTGLDTDSF-----LMALRRF-VARR-GQPYEVICDQGTNFHGG ESELK-N-------AFEHLSPV------------------------LK---EKLWNHQIK ----FTYNPPYAPHFGGTWEREIRSIKSALRSTLG--S---Q--TV----KEEVL----- --ATV-----LVEVEEILNSKP--------LGY------------V-------------- ----------------------SS-------------SAE-------------------- ----------- >R859/1-544 ---YTKRTVLSTIAQLYDPLGLLSPIIVQAKILLQE-LWAN-K----------L------ -GWDD-E-LPR--QLCDKWEEFCEQLPMLA---R-FKIP--RFA--L------------- --TP-N-YN--YV-ELHC-FADASEA-AYG-ACAYLR--SQSI-DG------TTQV-T-- LLAS---------------------------KSRV-APL-------K------------- ---P----------------------------LTIPRLELCAAL-LAA-RLQQKLISA-- -I-D----M-A-V---NET---HM---------WS------------------------- ------------------------------EDSMAAVHYLPHHPV-------VKES-STT TKV-RVVFDGSAKTT-TG---HSLNDVLHVGPVVQ--DELLSLVVRFR---KYKV--AVI ADIEKMYRQVSMHPD--DRRLQR-----I------FWRFQ---E-TE---------VV-Q TFELATVTYGLAPSSFLATRT-LLQL------------A----EDE-GAPY--P-LATEA V-KKN--LYVDDL-ISGAE-S---IEQAIQLRDELT-SL-MSKG-------GFRFR-KWC SNEL-SV-LDGLTPDLLGTTA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TA NEAFVCTGVDYCGPIM-------------------------------------------- ----------------------------LKPV--HRKA---APQ------KA-YLC---I -FVCMS--TKAVHLELVGDLSTSGF-----LKALDRF-IFRR-NKPNHIYSDNGTNFVGA KNALH-Q-------VYQMLHDE-AQ------------------NRQIN---NYLAEEGIE ----WHLIPPRAPNFGGLWEAAVKVAKKLLVRQLG--V-----SLL----SYEDL----- --ATV-----LIKIEGCMNSRP--------LTP------------L-------------- ----------------------SN--------DPN--D-------L-------------- ----------- >R860/1-536 ---YTRRGVLSTINSLFDPFGFAAPVVIQGRLLLRT-LTTE-S----------C------ -DWDA-P-LSS--EKFKEWKIWRDSLKKLE---L-VKIP--RTY--A------------- -TISLHQ--AQRR-EMCV-FCDASTN-AIA-AVAYSK--ITSI-SG------NVEV-G-- FIFG---------------------------KVKL-APR--P-E---------------- --------------------------------ISVPRLELCAAV-LAV-EIAEIIADE-- -I------D-IKL---DVV---TF---------YS------------------------- -------------------------------------WYLPMFGV-------YHPK-K-P GQI-RVVFDSSAQ-H-QG---VSLNDVLLTGPNAN--NSLLGVLLRFR---KERV--AVM ADIQQMFHSFVVAKE--HRNFLR-----F------LWYAN---SDLN---------SEVR EYRMRVHVFGNSPSPAVAIYG-LRRA------------A----LTG-EQDY--GFEARHF V-ERN--FYVDDG-LTSFP-T---EEEAIKLLKDTQ-EM-LAQS-------NLHLH-KIA SNKV-EV-MKAF-------PSEDLAKEL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SI DPPFSFVGVDIFGPWM-------------------------------------------- ----------------------------VT--SR-RTRGGQA-NS-----KR-WAV---L -FTCMS--TRAIHIEVMESMDSSSF-----INALRRF-FAVR-GPAKQLRSDCGTNFVGA CKELK-M-------EAI-TDDR-K----------------------VQ---EYLSNKSCI ----WIFNPPHSSHMGGSWERMIGVSRRILESMLQ--GI--ALSKL----SHEVL----- --ITF-----MAEVTAIVNNRP--------L--------------V-------------- ----------------------PV-------------ST--------------------- ----------- >R863/1-569 ---YTKRSIIRTIAKIYDPLGIVDTVKAKAKQFMQR-VWSL-K----------K-ENGDS YGWDE-E-IPQ--QMRQEWEVFERQLTHLQ---E-VQVP--RCV--T------------- -IVGAR-----NI-QIHG-FCDASEE-GYG-ACVYVR--STNG-EE-------IVS-R-- LFVS---------------------------KSKV-TPL--A-T--K------------- --------------------------------HTIARLELCAAH-LLG-KLLVKLKRA-- -TED--------P---YET---FC---------WT------------------------- -------------------------------------YYMPHHAV-------FKQD-STT TKC-RVVFDGSCKTS-NG---RSLNDILKVGPTIQ--QDTTDILLRWR---RRAI--AVV GDVEKMYRQVWVHEE--DRKFQR-----I------LWRSH---S-SE---------KI-K TYELNTITYGTASAPFLAIRT-LNQV------------L----EDN-KEKY--P-LAAS- R-IND--FYVDDF-ISGAD-S---ENEAKQLCEETK-AA-LAMG-------GFPLR-KWA SNCP-HI-LPSET-EIDNIQRVIE-LKSRE------------------------------ -G-AV-----------------ST--LG-------------------------------- -----LVWNPILDTLGV-------------KI---------------------------- ----------------------------------------------------------RQ ARPFSISGVDYAGPIM-------------------------------------------- ----------------------------VKGT--HRRA---VPT------KG-YIS---I -FVCFV--TKAVHIELVSNLTSSAF-----LAALRRF-VARR-GHVTELHSDNGTNFRGA NNKLR-E-------LYKLLNSD-TH------------------QDEVV---GWCAERDMK ----WKFTPPAAPHFGGLWEAAVKSMKFHLKRVLG--T-----GHL----TFEDL----- --STL-----LAEIEACLNSRP--------ITA------------I-------------- ----------------------SE--------DPN--D-------M-------------- ----------- >R864/1-554 -----RRGILSAVASVYDPLGLIAPVLFNGKRILQE-MCKN-G----------S------ -GWDD-P-LMD--GLSLRWVKWKQDLQSLQ---N-LSIP--RTY--V------------- -PLNFGK--PISI-ELHH-FSDASND-GYG-QCSYVR--VKNE-EG------NVHC-A-- LVMA---------------------------KSRV-APL--K-V---------------- --------------------------------VTVPRLELAAAV-VSV-EVSNVLKRE-- -L------D-YPV---ANE---TF---------WT------------------------- ---------------S---------------GKEGETWYLPHHGV-------FHPK-K-A DKL-RVVFDCSAR-H-EG---SSLNDHLLQGPDLI--NSLHGILIRFR---QHPI--ALT CDVEKMYHQFHVDEP--DRDFLR-----F------LWWKN---GDIT---------QPVH EFRMKVHLFGAASSSGCANYG-LKHL------------A----TEN-GELY--PLGS-QF L-LKN--FYVDDG-VISVE-N---VHEAIKVADEAR-RL-CALG-------GLRLH-KFL SNNE-LV-LKGI-------PQSERMCGVRGLD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DP SPPFLYTGMDCFGPFS-------------------------------------------- ----------------------------VK--SR-R-----N-VQ-----KR-YGL---L -LTCLC--SRAVHIELLNDLTTDSF-----INALRCF-IAIR-GTVRQLRSDQGTNFVGA RNELK-G-------ALCEMDPE-R----------------------IT---TFLLENQCE ----FIMNTPHASHAGGVWERQIRTIRSVLNATFA--L---YPGKL----DDSCL----- --RAF-----LYEAMAIVNSRP--------LTV------------D-------------- ----------------------CL--------N----DPQSLRPITPNNL---------- ----------- >R867/1-557 ----TKRIALSDASRLYDPLGLIGPTIMIAKCFMQN-LWAL-Q----------K------ -AWDE-P-LEK--ELHKQWNQFRQQLSIVK---D-MRIP--RRV--V------------- --GST---H--RI-EIHG-FSDASMK-AYG-ACLYMK--SVSE-DG------KVSV-N-- LLCS---------------------------KSRV-APL--A-NSKR------------- ---QKN--------------------------VTLPRLELSAAL-LLC-HLWQKVKDS-- -L-K----H---E---YSC---FY------------------------------------ -----------------------------------PIYYLPHHCI-------LRPD-SLT TKL-RVVFDASCATD-SG---LSLNDALMVGPVVQ--DDLVAIMIRFR---LPKF--AIV ADIEKMYRQVWIKKE--DRSLQR-----I------LWQNC---P-EN---------KL-R IYELKTITYGTASAPYLATKC-LQML------------S----VHG-TSTH--P-EASRV L-ANE--FYMDDL-LTGVE-T---QTEGEELCHQLT-DL-LSSA-------GFTLR-KWA SNSS-QI-LQSIPVDQRDTSG--L-C-SLD---------------------------I-- -NSSI-----------------KT--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------TP TFPFLNTGVDFCGPLF-------------------------------------------- ----------------------------YRSA--SRKS---APV------KC-YVA---V -FVCLA--TKAIHLELVADLSSDAF-----ISTLKRF-VARR-GKPSLLQCDNAKNFRGA ERKLK-V-------FHQQLQQQ-QF------------------QQSIS---SYCGPEGIE ----FRFIPPRSPHFGGIWEAAVKSFKHHFRATIG--T-----SIL----RRDDL----- --ETI-----IAQVESCLNSRP--------LTP------------I-------------- ----------------------ST--------EPE--D-------L-------------- ----------- >R871/1-547 ---PTKREVLKCVMSLFDPLGLLANFTIHGRILIQD-LWRA-G----------T------ -GWDE-A-ISP--SQMRDWRRWVDVFPLIA---Q-LRIP--RCY--F------------- -PEAREK-VYENA-ELHL-FVDASQL-AYA-CVLYLR--VVDS-EG------EPHC-T-- MLCG---------------------------KAKV-APL--K-P---------------- --------------------------------LTIPKMELQACL-LGA-RLLKSTEQH-- -H------P-ISV---KKR---VL---------WT------------------------- -------------------------------------WYLPLGVV-------TNPK-K-P GKV-RIIWDAAAK-V-QG---TSLNDMLLKGPDEL--ISLPGVLFRFR---MYGI--AVC ADVKEMFLQIRMRDE--DKHAQR-----F------LWRED---P-AD---------D-IA TYFVDVVTFGSACSPATAQYV-KNRN------------A----KEH-AEKY--P-RAVRG I-LTS--TYVDDY-LDSFG-T---FEEASRVSREVR-GI-FSNG-------GFVLR-NWV SNNP-VV-LERL--GGE----SSSPGMKSLTS-----------------------TADDG ----E-----------------RV--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------AF VRPFTFVGLDYFGPLL-------------------------------------------- ----------------------------VR--RG-R-----A-QE-----KR-WVA---L -FTCLT--IRAIHLEVVSSLSTDSC-----ILAVRRF-VARR-GAPVEVFSDNGTNFVGA SQQLR-K-E------IDE-RND-A----------------------LA---ATFTNANTR ----WTFNPPGAPHMGGVWERMVRSVKAAMSTMTE--L---Q-RTP----DDETL----- --LTV-----IVEAEGMINTRP--------LTY------------I-------------- ----------------------PL-------------ES--------------------- ----------- >R875/1-552 ----TKRSVLSAIAKMYDPLGMIAPIIIRAKMIMQE-IWVS-S----------R------ -DWDE-S-LPE--DIVCKWKQFQKEIRSLS---Q-YRMD--RFI--L------------- --LP-E-AR--NI-ELHT-FADASSA-AYG-ACTYVR--CEDA--G------RVRV-M-- LLAS---------------------------KSKV-APL-------K------------- ---N----------------------------LTIARLELCACV-LAA-HLHHRIKGA-- -I-D----V-A-V---NAS---YF---------WT------------------------- -------------------------------------------------------S-STT TKI-RVVFDGSSKTT-SG---YSLNDALCVGPVVQ--DDLLDQLLRFR---TYKV--ALV GDIAKMYRQILLHPD--DRPLVR-----I------LFRFE---P-QQ---------PV-Q TYQLNTVTYGLAPSSFLATRA-LIQL------------A----DDE-GNAY--P-RAGPA L-RKN--FYVDDF-IGGAQ-S---VEEATCLRTELA-EL-LQKG-------GFELR-KWT SNCV-DV-LHGLDEAQVGTTT--K-M-SFD---------------------------S-- -HEAV-----------------KT--LG-------------------------------- -----ISWVPQGDWLVFEG----------------------------------------- ----------------------------------------------------------IP SRPFAVTGVDYAGPLY-------------------------------------------- ----------------------------LKPA--HRRA---ASL------KA-YLC---V -FVCFA--TKAVHLELVGDLSTDGF-----LAALRRF-TARR-GVPDHLHSDNGKNFEGA RNELR-E-------LFATLTSE-AA------------------QSTIA---SSCADQGIS ----WHMIPPRAPHFGGLWEAAVKTAKRHLFRHLG--S-----TRL----SFEGY----- --YTV-----LHQIEAAMNSRP--------LLP------------L-------------- ----------------------TD--------DPN--D-------L-------------- ----------- >R876/1-550 ---PTMRNIYRVLASQYDPLGYILPYTTRAKILVQA-LWIN-K----------C------ -GWDE-CIGGD---MQDKWEQWTNELQYLS---R-ITIP--RCY--F------------- -PICPES-NKPKL-ELHI-FCDASER-AYG-SVAYLR--LEGE-DG------RIYT-S-- FVMA---------------------------RSRV-APK--K-Q---------------- --------------------------------ISMPRLELCGAL-TGA-QLAKLLITE-- -L------T-LPI---NNT---NL---------WT------------------------- -----------------------------------ESWYIPHHLV-------HHN----- SKA-RVVFNCSYQ-F-HQ---DSLNDQLLPGPMLS--PSLLGVLLRFR---QYPV--AIS GEIRSMFHQVRLLPE--DHQLLR-----F------LW-RN---MEKE---------RSPD IYEWRVLPFGTTCSPCCAIYA-LQRH------------V----TDH-REG---NEEVVES V-LNS--FYVDNC-LQSFL-S---TNEAKQLIDKMR-AL-LAAG-------GFEIR-QWA SNYA-EV-ISHL-------PTEARSE-----L-----------------------SMVDC -EQNR-----------------HA--RV-------------------------------- -----YTWALLALHL--------------------------------------------- ----------------------------------------------------------LH QPPFWSTGVDCFGPFT-------------------------------------------- ----------------------------IK--IG-R-----R-HE-----KR-WGI---I -FKCLT--TRCIHLDLLHSMDSDSF-----LMALRRF-IARR-GKPFEIISDQGTNFRGG SRELQ-E-------AFSALEPD------------------------IK---EKLSEQSIS ----FQFNPPHAPHFGGAWEREIRSIKSCLRVVLK--D---Q--IV----TEEVL----- --TTV-----LIEVEGILNSKP--------LGY------------V-------------- ----------------------SS-------------EI--------------------- ----------- >R879/1-528 ---WSRRKVYSLVARIYDPLGLVAPVTSWAKINMQS-LWLA-T----------D------ -DWDE-E-IPA--VMQERWYAFQSQLGLLK---E-VKFS--RHA--V------------- --VH-N-PV--AV-QLHC-FSDASEA-AYG-ACVYVR--TIGS-SG------EVVV-E-- LLAA---------------------------KSRP-APL-------K------------- ---R----------------------------VSLARLELCGAL-LAA-RLQKVVRQA-- -L-R----I-P-D---VET---FM---------WT------------------------- --------------------------------------FLPHHPV-------IKAS-STS TKV-RPVFDGSASTD-GG---KSLNDLLMTGPVIQ--ENLLALLLKFR---MRSV--ALV ADIKQMYLQVKVHPD--DTRFQR-----V------LWRGS---S-VE---------SI-E VYELQRVTFGLAPSSFLAIRV-LQQL------------A----IDE-GENF--P-LARQA L-LED--FYVDDY-IGGAS-S---EEEAVRLQAELT-LL-LRKG-------GFHLT-KWN SNKP-DV-LSSVS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MP ARPFSIVGVDFCGPIY-------------------------------------------- ----------------------------LKPV--HRRA---AAE------KA-YIS---I -FVCFS--VKAVHIELVESLSTHAF-----LAAFRRF-VARR-GLPSEVYSDNGLNFQGA SKVID-D-------FYTLMNSD-SA------------------VEDIS---RYAVGAGVK ----WHFIPPHAPNFGGLWEAAVKAAKRVLLKVVG--D-----RQL----AFGEM----- --STV-----LAQVEAQLNSRP--------LTP------------L-------------- ----------------------SE--------DPE--E-------L-------------- ----------- >R881/1-556 ---PTKREVLRCVMSLYDPLGLLAMFVIHGKILIQD-LWRT-G----------T------ -QWDE-E-IND--MQLRHWRRWIDLLPAIA---D-LRIP--RSY--F------------- -AAASKK-MYENG-EWHL-FVDASQH-AYA-CVLYLR--IFDD-AG------EPQC-T-- LIGG---------------------------KAKV-APL--K-P---------------- --------------------------------LTIPKLELQACV-LGA-RFLRYTQEH-- -H------P-INV---RRR---VL---------WS------------------------- -------------------------------------WYLPIGVV-------TNPN-K-P GKV-RLIWDAAAK-A-HG---TSLNDMLLKGPDEL--SSLLGVLFRFR---LYAV--AAC ADVKEMFLQIMIRKE--DKHAQR-----F------LWRYE---P-TD---------E-LE TYIVDVVMFGSACSPATAQYV-KNRN------------A----REH-MEQF--P-RAVEG I-IES--TYVDDF-LDSFE-T---EEEACQVSHDVR-EI-FRNG-------GFELR-NWT SNSM-EL-MRCL--G------EANGDIKCLSS-----------------------MGDEA ----E-----------------RV--LG-------------------------------- -----MRW---------------------------------------------------- ----------------------------------------------------------PF VRPFSYVGLDYFGPVL-------------------------------------------- ----------------------------VK--RG-R-----S-NE-----KR-WIA---L -FTCLT--VRAIHLEVVHSLSTESC-----VLAVRRF-VARR-GAPVEIFSDNGTNFLGA SRQLR-R-E------IEE-RNE-T----------------------LA---AIFTNAHTR ----WTFNPPGAPHMGGVWERMVRSVKAAISTVME--A---K-HAP----DDETF----- --ETV-----ILDAEAMINSRP--------LTY------------V-------------- ----------------------PL-------------DPENQEAITPNHF---------- ----------- >R882/1-601 ---TTMRNIYRILASQYDPLGYLIPYTTRAKILVQQ-LWDK-K----------R------ -DWDD-PHLPT--DLLQTWTEWEAELPALQ---N-IVLP--RCY--C------------- -SANKDT-ETSLR-DMHV-FCDASER-AYG-SVAYLR--TEDQ-YG------QVEV-A-- FLTA---------------------------RSRV-APK--K-Q---------------- --------------------------------QSIPRLELCAAL-TGA-QLSKVLLTE-- -L------N-LPI---RHT---IL---------WT------------------------- -----------------------------------CSWYIPHHMV-------EHN----- GKN-RIVFNCSFQ-Y-HG---QNLNELLLPGPVLG--PSLLAVLLRFR---EHSV--AVS SDIKGMFHQVRLLPE--DKPLLR-----F------LW-RE---LNVQ---------EQPT VYEWQVLPFGTTCSPCCAIFA-LQKH------------I----LDH-SHP---GDDVQNS V-LKS--FYVDNC-LQSFT-S---AEAAKEFVDSIK-NQ-LADG-------GFELR-QWS SNIP-ST-INHL-------PPESISSSAELWI-----------------------SQGKS -DIQE-----------------ST--LG-------------------------------- -----LLWNHQSDTLSYKYRAKDSRETTMRNIYRILASQYDPLGYLIPYTTRAKILVQQL ----------------------------------------------------------LF KPAFHSTGMDCFGPYT-------------------------------------------- ----------------------------VK--TG-R-----R-NE-----KK-WGI---I -FKCLT--TRAVYIDILHSLETDSF-----LMALRRF-TARR-GKPQELLSDQGTNFRGG ERELK-E-------AFTALAPD------------------------LQ---SQLAKQQIE ----FHFNPPNSPHFGGCWEREIRSLKNALMVTLG--N---Q--SV----TFEVL----- --QTV-----LAEIEGILNSKP--------LGY------------T-------------- ----------------------SS-------------DA--------------------- ----------- >R885/1-547 ---PTKRDVLRTVMAIYDPMGIIANFLMYVKILMQE-IWRA-G----------L------ -GWDD-V-LSG--RLAEKWSVWVAVLPTIS---Q-VRVP--RCY--R------------- -QFTSV---NAKI-QLHV-FCDASEN-GMA-AVAFFR--FND--GG------IIEC-S-- LVGA---------------------------KTRV-API--K-F---------------- --------------------------------VSIPRLELQAAV-IGA-RFAAAIIAQ-- -H------R-IAI---ERI---FY---------WT------------------------- -----------------------------------RDWFLPIFPV-------FNAN-K-P GKV-RVVFDAAAK-V-QG---VSLNTYLLNGPDLL--AGLLSVLYKFR---EHRV--AIV GDIKEMFFQVRMKPD--DQRSQM-----I------LWNEN---DFTG---------SEPD VYAVAVMTFGAACSPSTAQFI-KNLN------------A----DRF-ADKY--S-RAVKC I-KEE--HYVDDL-LASAE-T---DEEIITLAEQVR-HI-HAEG-------GFEIR-NWL SNSH-RV-TSHL--QR---EASP---EDKINM-----------------------CSD-D RT--E-----------------KV--LG-------------------------------- -----MWW---------------------------------------------------- ----------------------------------------------------------AY QKPFSFTGVDYFGPVT-------------------------------------------- ----------------------------VA--VG-R-----R-VE-----KR-WGV---L -FTCLT--TRGIHLEAAHSLTTSSC-----ILAIRRF-IARR-GQPLEFISDNGTNFVGA SRELA-E-------AWEAIDKQ-R----------------------LA---EEFTTPRLA ----WKFIPPGGPHFGGCWERLVRSVKKAMSEIRM------S-RLP----TDEVL----- --TTA-----LTEIEAMLNSRP--------LTQ------------V-------------- ----------------------PL-------------DS--------------------- ----------- >R886/1-549 ---TTRRGILSTVASIFDPLGFVAPFVLNGKRILQE-MCRQ-G----------T------ -GWDD-T-LYP--ALKPRWERWQNDLVNLE---N-VNIP--RCY--V------------- -PADFGK--VVKT-EMHH-FSDASTC-GYG-QCSYLR--MINE-DD------EIHC-S-- FLIG---------------------------KARV-SPL--K-I---------------- --------------------------------ITIPRLELTAAV-VSV-SMSNILSEE-- -L------N-LID---VDK---FF---------WT------------------------- -------------------------------------WYIPHHGI-------YHPK-K-P DKL-RVVFDCSAK-F-KG---TSLNEHLLSGPDMI--NNLTGVLVRFR---RHPI--AVI CDIEKMFHQFHVQEK--DRDYLR-----F------LWWKD---GDTN---------SVLQ DYRMKVHLFGAVSSPGCANYG-LRYL------------A----NEY-SQSH--ALGA-QF I-TRD--FYVDDG-VTSAE-T---VEKAIQLTKEAR-EL-CAKG-------GLRLH-KFV SNDN-TV-LQSI-------PESERAVNFETKD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SPPFMYCGMDCFGPFM-------------------------------------------- ----------------------------TK--EG-R-----K-NH-----KR-YGL---L -LTCLC--SRAIHIEMLEDMSTDAF-----INSLRCF-IAIR-GTVRQIKCDQGTNFIGA KNELN-S-------ALQELDPE-R----------------------LT---TFLANKQCD ----FVLNAPHSSHAGGVWERQIKTVRSVLNATIT--L---SAGRL----NDASL----- --RTV-----FYEAMAVVNSRP--------LTI------------D-------------- ----------------------NL--------N----DPKSLEPLTPNHL---------- ----------- >R890/1-551 ----TMRKIYRTLAKLYDPLGYLIPYTTRAKTVVQL-LWDK-K----------R------ -EWDD-PNLPE--DLLAIWHQWENELPNLS---Q-VFLP--RCY--T------------- -SH-IQC-TVKHR-CVHV-FCDASER-AYG-SVAYLC--SEDE-QD------NRHV-S-- FIAA---------------------------RSRV-APR--K-Q---------------- --------------------------------ISIPRLELCAAL-TGA-QLGDVLKRE-- -L------T-LNI---NQF---VY---------WS------------------------- ---------------S---------------ESSAQSWYIPHHMV-------QHN----- GKN-RIVFNCSFE-Y-KG---QSLNEYLLPGPTLG--SSLLGVLLRFR---EYPV--AIC SDVKGMFHQVRLLDE--DKPFLR-----F------LW-RQ---GKTS---------EMPV VHQWEVLPFGTACSPCCAVFA-LQSH------------V----KGD-LDP---TDEVRQT V-ERN--FYVDNC-LSSVP-T---ESQAKNLVNRLQ-CH-LMDG-------GFELR-QWA CNIP-EV-IQHL-------PNDLKSKSGEIWL-----------------------SQG-- ------------------------------------------------------------ ----------------------------------------------I------------- ----------------------------------------------------------LF KPPFYSTGVDCFGPLM-------------------------------------------- ----------------------------VK--IG-R-----R-IE-----KR-WGI---I -YKCLT--TRAVHLDLLYHMDSDSF-----LMSLRRF-IARR-GKPHELLSDQGTNFKGG ANELE-D-------TFNQIQPI------------------------LR---DMLAKDQIR ----FQFNPPSAPHFGGSWEREVRSVKTALRSTLG--A---Q--TV----TEEVL----- --RTI-----LTEVENILNSRP--------LGY------------V-------------- ----------------------SS-------------DIADPDPVTPNSL---------- ----------- >R893/1-555 ----TRRGMLSVTNSLFDPLGFVAPVVLEARLIYRD-LCLM-K----------T------ -DWDE-E-VTG--TELERWKAWCNSLNELT---R-IRIP--RCF---------------- --KPQVRHPTPGV-QLHV-FADASTA-ARG-CVCYLR--TTFE-DD------NTTC-S-- FVMG---------------------------KSLLCDSG--K------------------ --------------------------------HTIPRLELEAAL-DAV-KLSRTVKRE-- -L------G-LDD---CPC---IY---------WT------------------------- ---------------V---------------NTTNKLWYLPHHPV-------INPK-K-P SKV-RIVYDCAAK-C-EG---QSINDKLMKGPDLV--NPLVGVLMRFR---RERV--AIV SDIEAMFHQVLVAQK--DRDALR-----F------LWWPG---GDLT---------KSPV PHRMKVHLFGARSSPCCATFC-LRET------------A----REF-GKFF--HPRVAEV V-KNN--FYVDDC-LVTAV-D---DQAGIQLVKDLR-NL-LSMG-------GFKLT-KWL STSV-AV-MESV-------PADDRAKVIQDIP-----------------------L--GG -EVHE-----------------RV--LG-------------------------------- -----INW---------------------------------------------------- ----------------------------------------------------------ID EPPFTHTGVDFFGPLL-------------------------------------------- ----------------------------TK--LR-R-----S-EV-----KR-YGC---L -FTCMT--TRAIHLEVATDLSTDAF-----INALRRF-TARR-GPVTHLYSDNGTNFVGC ERILR-E-------CIEEWNRN-Q----------------------VG---DYLRQKNII ----WKFNPPAASHFGGAWERLIRSVKFILQALLQ--G---K--PL----DDDLL----- --HTL-----LVEVEDIVNSRP--------LTQ------------V-------------- ----------------------PL-------------E-----------I---------- ----------- >R897/1-550 ---WTKRQVLASIAECFDPCGIISPTLLKGKWLMQK-LWE-SK----------M------ -TWDN-P-LNE--ELKIEWELIKDEYLSCN---T-IQVT--RRL--I------------- ----SWKMTKPTV-YELCAFSDASDK-ALG-FAVYLR--SQNGRE--------IQT-A-- LIFA---------------------------KSRV-KPK--AQLGKCETK---------- --------------------------------MTIPRMELHAAL-IAT-KALDYLEEM-- -L------E-IKIA---KK---ML---------WT------------------------- ------------------------------------------------------ED-KTF TKF-RIVFNASGKSRKDN---PSLNDCLHQGPVTI--QDLCGLLMRSR---FPTY--LIA GDLQAAFLQISLRPP--DRDSVR-----F------LWVSDIKKP-SE----AQTD-EDLR IFRYARVTFGVNCSPSILGMTVDHHL------------S--------KYDS--TTA--EK L-KKA--GYVDNF-LIGAE-E---NAEVEKDILEAR-KI-FQDA-------GWNFR-EIF TNAS-KQ-LNDIPFEKLPIEARTSNLCSGAKQ---------------------------- ----------------------KI--LG-------------------------------- -----ISW---------------------------------------------------- ----------------------------------------------------------NQ FRPFMYSSVDYFGPMT-------------------------------------------- ----------------------------IKLK-NAEHI------------KR-WVA---V -YTCTS--TRAVHLEIAEDLSAQAF-----LKTFRRF-IAHR-KKPVLMISDNGTNFKAA EKILK-S--------------I-FK---ET---------------QIQ---KFASDHEIK ----WIFVTERAPWKNGLVERMVGLIKYSLRRTVG--R-----RLL----EEEEF----- --RTL-----ITEVQTVVNSRP--------LNF------------I-------------- ----------------------PD--------S-E--Q-------V-------------- ----------- >R899/1-564 ---PTKREALSFVMSAYDPLGLISHITIQGRILMQS-INAA-T----------N------ -DWDT-Q-IPD--SLHGKWIEWLKMITSVK---D-LAIP--RPI--V------------- -ASI--M---NPV-EIHT-FVDASQE-AFA-AAVYAR--SNFN-GC-------FVV-R-- LVAA---------------------------KSRV-APT--K-A---------------- --------------------------------LSIPKLELQAAV-LGA-RLTASVIKE-- -L------R-LKI---SRT---IF---------WS------------------------- -----------------------------------KIFYIPHFVV-------VNKN-KPI PKP-RLVFDAAAK-V-NG---VSLNSLLLTGPDEM--ASLFGVLLRFR---EGPI--CVC GDIKEMFHQVKIRKE--DQDAQR-----I------LWRDG---D-ST---------RTPD TYVMQVMTFGATCSPACAQVV-KNRN------------A----EAN-SEMY--P-LALEP I-RNQ--HYVDDY-LDSFF-S---MEKAIKTVTEVI-QV-HENG-------GFHIR-NFI SNKR-EL-MEAI--------PQERHQVKAI-V-----------------------DIKEK DSCVE-----------------KI--LG-------------------------------- -----VQWNTQLDCFGYKV----------------------------------------- ----------------------------------------------------------PY NPPFLHTGVDYFGPLD-------------------------------------------- ----------------------------VT--VK-R-----S-TE-----KR-WGA---I -FTCMS--TRAVHLELAEKLDTDSF-----MVCLNNF-LHRR-GKITHLYSDNGTNFVGA EKELK-K-------IVEDIDLR-M----------------------GR---EAALKYKIE ----WKFNPPAAPHFGGSWERLIQNIKKALRHMVT--EWK-T-RHP----TPETL----- --RAT-----LIQIESILNSRP--------LTH------------L-------------- ----------------------PL-------------TSEEE------------------ ----------- >R902/1-544 ----TKRVVCSELAQIFDPLGLFAPVVVKAKIFMQQ-LWEL-K----------L------ -DWDD-E-LPL--QHQTEWKEYRDDLQTLN---K-MQIP--RHI--Y------------- --DGKI-PV--TQ-ELHT-FVDASER-AYG-AAVYVR--ATYK-NN------QVSV-R-- LLCS---------------------------KSRV-APT--A-K---------------- --------------------------------QSLPRLELCAAV-LGA-ELTNRVRQD-- -L-H----M---D---RNTVSG-----------WL------------------------- -------------------------------------------------------E-STT TKL-RVVFDASCKST-SG---KSLNDILQAGPTVQ--SELMSILLRFR---IHKY--VFT ADIEKMYRQVWMNPE--DQFHQM-----I------VWRNN---P-SE---------EI-R YYRLKTVTYGTTAAPFLATKC-LDHL------------A----IQY-KDRL--P-VGSTT L-KTD--FYVDDC-LTGAN-T---IPEAIHVRQELN-KI-LLPS-------GFKLR-KWC SNNE-KL-LQGIPKEDIVTDVKLG-ET-LE------------------------------ -HYSV-----------------KT--LG-------------------------------- -----LIW---------------------------------------------------- ----------------------------------------------------------TQ ARPFLNAGVDYCGPIA-------------------------------------------- ----------------------------IHHK--IRGK---RPD------KA-YIA---V -FCCFS--TKAVHLELVSDLTTEAF-----LAALRRF-LSRR-GKCQTIHCDNATNFVGA NNQLK-E-------LEDSIFSS-KA------------------SALIT---NHCNKKQVD ----FKFIPPRAPSFGGLWEAAVKSAKRLLITTTN--T-----ASL----TFEEL----- --NTV-----IIEIEAILNSRP--------ITP------------M-------------- ----------------------SN--------DPT--D-------T-------------- ----------- >R903/1-528 ----TMRNIYKVLARQYDPLGFIAPYTTRAKLIVQS-MWDK-P----------R------ -DWDD-PCIPP--DLQKAWTTWESELHWLP---H-IAVP--RPY--A------------- -PGLTEP-MVVSR-QIHV-FSDASTK-AYG-SVAYIR--TEDV-QG------RIQV-A-- FLAA---------------------------RSRV-APR--R-Q---------------- --------------------------------HSIPRLELCGAL-TAA-QLAKKIETE-- -L------T-IKT---DKP---IL---------WS------------------------- ---------------V---------------LDSAESYYIPHHVV-------RHN----- GKS-RIVFNCSFP-Y-QG---RSLNDTLLPGPTLG--ASLLGVLLRFR---EHAV--AIS SDIRGMFHQVQLLPE--DQPLLR-----F------IW-RD---MKRA---------DPPA VFQWQVLPFGTACSPCCATFA-LHRH------------A----RDH-SGV---NNAVLHS V-EHC--FYVDNC-LQSLP-T---AEEAKELVDQLR-DV-LASG-------GFELR-QWA SNVP-DV-LRHL-------PAEV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LY QPAFYSTGVDCFGPFQ-------------------------------------------- ----------------------------VR--IG-R-----R-SE-----KR-WGI---I -YKCLT--TRAVHLDLLHAMDSDSF-----LMSLRRF-IARR-GSPAELYSDQGTNFRGG EKELS-E-------WFSRMSPD------------------------LQ---QLLAKQKIA ----FCFNPPAAPHFGGTWEREIKSVKMALNTVIG--A---Q--PI----SEEVL----- --RTV-----LLEVEAILNSKP--------LGY------------T-------------- ----------------------SS-------------NV--------------------- ----------- >R905/1-568 ----TRRGILSTVSSVFDPLGCVSPVVLPAKQLLQT-LCRS-Q----------L------ -GWDA-E-IPS--ELMRKWLQWRTELPKLM---Q-FKMD--RCL--K------------- -PDGFA---PQSV-TLHH-FSDASEK-GYG-VVSYLR--WEN--ED------EVQM-K-- FVTS---------------------------KARV-APL--K-E---------------- --------------------------------VSIPRMELTAAN-VAV-RIDHMIKQE-- -L------D-IPI---EET---YF---------WT------------------------- ---------------K---------------RDDGRVWYLPHHGV-------VHPQ-K-- KKL-RVVFDCSAE-F-GV---FCLNRELLQGPDLT--NTLFGVLTRFR---QDKV--ALM ADIEGMFSQVRVPKD--DRDLLR-----F------LWWEK---GDIE---------QPLT DHRMKVHVFGAVSSPSCANFA-LKRA------------A----QEQ-ADSF--SNEVTST I-QKN--FYVDDC-LFSTP-S---VQQAVKLATDVT-AA-CEGR-------GFHLT-KWV CNEP-EV-MKTI-------PEKEKAKSVQDLS-----------------------LDNKN -QVTE-----------------RA--LG-------------------------------- -----IIWSTSEDTFGVKI----------------------------------------- ----------------------------------------------------------PD EPPFTKVGIDYFGPLV-------------------------------------------- ----------------------------VK--RG-R-----S-EV-----KT-YGV---M -FTCLA--IRAIHIEKAESLSTDSC-----IAAIRRF-IARR-GTVKEMRSDNGTNLIGA QRELK-R-------EIENWNQA-Q----------------------IS---DAMLQRNIQ ----WTFNPPGGSHHGGVWERQIRTVRQVLFNLVR--Q---Q--RL----DDEGL----- --QTF-----LCEAEGIINGRP--------ITK------------A-------------- ----------------------SN-------------D--------PNDL---------- ----------- >R913/1-605 ----TMRHIYRVLASQYDPLGYIIPYTTRAKILVQR-LWDK-K----------R------ -DWDD-PHLPE--DLLALWHEWEKELSGLE---E-ISLA--RCY--S------------- -LSEVDH-ASCKY-EIHI-FCDASEQ-AYG-SVAYLR--IEHK-EG------EVEV-A-- FVAA---------------------------RSRV-APR--K-Q---------------- --------------------------------QSIPRLELCAAL-SGA-QLSQLLNTE-- -L------T-VPI---HST---TL---------WS------------------------- ---------------A---------------DCSKESWYIPHHMV-------QHN----- NKN-RVVYNCSFQ-F-EG---HSLNDFLLPGPTLS--PSLLAVLLRFR---EHPV--AIS SDIRGMFHQVRLLPG--DMPLLR-----F------LW-RD---LKPD---------LPPD VYQWQVLPFGTTCSPCCASYA-LQTH------------V----INH-SQP---GDRFREV I-EKS--FYVDNC-LHSLH-S---PKEAKDLVDGLC-AL-LASG-------GFELR-QWA SNCP-SV-ITHL-------PPESRSSTCELWL-----------------------SQDQQ -DVHE-----------------ST--LG-------------------------------- -----LQWHCQTDTLRYKHRARSSAPVTMRHIYRVLASQYDPLGYIIPYTTRAKILVQRL ----------------------------------------------------------YF RPVFYSTGMDCFGPFV-------------------------------------------- ----------------------------IK--IG-R-----R-NE-----KR-WGI---V -FKCMT--TRAVHLDLLSSIDSDSF-----LMALRRF-IARR-GNPHELLCDQGTNFKGG ERELN-E-------AFAALQSE------------------------LQ---NHLAVQQIK ----FTYNPPSAPHFGGCWEREIRSIKAALKVTIG--A---Q--TV----TEEVL----- --RTV-----LIEVEGILNSKP--------LGY------------T-------------- ----------------------SS-------------DV--------------------- ----------- >R915/1-564 ----TMRNIYRVLASQYDPLGVILPYTTRAKVIVQH-LWVK-H----------R------ -DWDD-PQLPG--ELQQEWMKWEEELKYLP---E-VTLP--RCY--Y------------- -PYYMDH-SDVRR-EIHI-FSDASEK-AYG-AVAYLL--TEDH-QG------ELHL-A-- FLLA---------------------------RSRV-APR--K-Q---------------- --------------------------------QSIPRLELCAAL-IGA-QLAKLLVNE-- -L------T-VKL---DKF---TY---------WT------------------------- ---------------K---------------ESTREKWYIPHHMI-------THN----- EKN-RLVFNCSFE-Y-EG---LNLNDSLLPGPVLS--PSLLGVLLRFR---EHCV--AIS GDIRGMFHQVLLLPE--DRPLLR-----F------LW-RD---LRRE---------EPPD TYEWQVLPFGTTCSPCCATFA-LQQH------------V----ALH-STP---DEDVRFS V-NKC--FYVDNC-LQSLP-S---AQEARQLVDKLR-AL-LSSG-------GFDIR-QWA SNKG-EV-ISHL-------PPEARSTKLELWL-----------------------SQDKA -EPRE-----------------ST--LG-------------------------------- -----LSWHCKSDNLGFKH----------------------------------------- ----------------------------------------------------------LF KPAFYSAGMDCFGPLM-------------------------------------------- ----------------------------VT--LG-R-----R-TE-----KR-WGL---L -FKCLT--TRAVHIEVLTSMTSDAF-----LMALRRF-IGRR-GQPAELYSDQGTNFRGG ETELR-E-------TFSTLGSD------------------------LQ---QLLAKQRIN ----FHFNPPASPHFGGVWEREIRSIKMALRTALG--S---E--TV----SEEVL----- --QTV-----LIEVEAILNSKP--------LGY------------V-------------- ----------------------SA-------------DL--------------------- ----------- >R917/1-536 ---YTRRGVLSTINRLYDPLGFVAPVTIQGKAILRE-LTAV-S----------G------ -DWDA-P-LPQ--KMEDAWTLWRVSLSELA---N-FSIP--RVY--T------------- -EISTST--AMRR-ELCV-FADASIK-AIA-AVSYLK--VTDD-EG------KNHI-G-- FVMG---------------------------KAKL-APR--P-E---------------- --------------------------------HTVPRLELCAAV-LAV-ELADLISVN-- -L------D-LQF---DAV---TY---------YT------------------------- -------------------------------------WYLPTFGV-------YHPK-K-V NQI-RVVFDSSAQ-H-NA---ISLNDVLLTGPDLN--NTLVGVMMRFR---KEAI--AFT ADIEQMFYCFLVREE--DRDFLR-----F------LWFQD---NDTS---------KDIV DYRMRVHVFGNKPSPAVAIHC-LHKS------------V----QID-NFHV--DSEVKQF V-MRD--FYVDDG-LKSLP-T---VEATISLLKKTQ-EV-LSKS-------NLRLH-KIA ANSK-KV-MEAF-------PSTDH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SA DPPFTNVGLDVFGPWN-------------------------------------------- ----------------------------VS--SR-RTRGGLL-YS-----KR-WAV---I -FTCMS--IRAVHIEVIESLDTSSF-----INALRRF-LAVR-GPVKHIRSDRGTNFVGA CKELQ-I-------PSN-IDSK-V----------------------VK---TYLSDQGCT ----WTFNPPHASHCGGSWERMIGLARRILDSMFL--QL--KD-KL----THEVL----- --VTF-----MAEVTAIINARP--------L--------------V-------------- ----------------------PV-------------TTDPHES---------------- ----------- >R919/1-524 ----TLRNIYKVLARQYDPLGFILPYTTRAKLIVQR-MWDK-P----------R------ -DWDD-PHIPQ--DLQEAWKEWESELHLLP---H-ISFP--RPY--A------------- -STPHSQ-MIVSR-QIHV-FSDASEK-AYG-AVSYLR--TEDS-QG------QVSL-A-- FLAA---------------------------RSRV-APR--R-Q---------------- --------------------------------HSIPRLELCGAL-TAA-QLAKTIARE-- -L------T-VVI---DQT---IL---------WS------------------------- ----------------------------------EESWYIPHHLV-------SHN----- GKN-RLVFNCSYQ-H-QG---RNLNDTLLPGPTLG--ASLLGVLLRFR---QHAV--AVS GDIKSMFHQVQLLPR--DRPLLR-----F------IW-RD---MMRM---------EPPD IYEWQVLPFGTACSPCCATFA-LQLH------------A----RTH-SKE---GDGVRHS V-EQC--FYVDNC-LQSVD-T---VDEARKLVDQIR-EV-LATG-------GFEIR-QWA CNLP-DV-IKHL-------PAEA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LH KPAFYSNGVDCFGPFQ-------------------------------------------- ----------------------------IR--IG-R-----R-SE-----KR-WGI---I -YKCLT--TRAVHLDLLHNMDTDSF-----LMSLRRF-VARR-GTPAELLSDQGTNFKGG EKELR-D-------SFNSMSLD------------------------LQ---QLLAKQKID ----FRFNPPAAPHFGGTWEREIKSVKSALHTVMG--V---Q--SV----SEEVL----- --YTV-----LLEVEAILNTKP--------LGY------------T-------------- ----------------------SS-------------SV--------------------- ----------- >R921/1-568 ---STRRGILSVISSLFDPIGFVAPFILQGKCILQE-LCRK-N----------I------ -GWDD-Q-LPE--DMYSRWEDWKGGLQRLK---E-VVIP--RCY--H------------- -PDTFNE--IIET-ELHH-FSDASNI-GYG-ACSYLR--FKND-KG------KVHC-S-- LVMA---------------------------KARV-APT--K-V---------------- --------------------------------TSIPRLELAAAV-LSA-KISVMLKTE-- -L------E-MKI---DRE---FF---------WT------------------------- ---------------------------------GETVWYIPHHGV-------YHPQ-K-P GKL-RVVFDCSAK-F-SG---ISLNDTLLTGPDLI--NSLVGVLCRFR---KELV--AVT CDIEKMFHQFLVPPD--ERNYLR-----F------LWWED---GDWE---------KEPQ DYRMTVHLFGATSSPGCANFG-LKYL------------A----QQY-EVKH--PTAS-EF V-KRN--FYVDDG-LASVR-S---IDEAKELITDAQ-AL-CKQG-------GLRLH-KFN SNKE-DV-LCCI-------DPSERDIVSKPLN-----------------------LNPEA -TPTG-----------------RV--LG-------------------------------- -----VQW---------------------------------------------------- ----------------------------------------------------------EV SAPFTFCGMDCFGPFV-------------------------------------------- ----------------------------VK--RA-R-----K-EY-----KR-YGL---I -FTCLS--SRAVHIEMIEDLSTDAF-----INALRCF-ISLR-GAVCKLYCDQGTNFVGA RNEFK-D-------CLKQVDIK-T----------------------LE---VFLAEKQCE ----FAFNAPSASHTGGVWERQIRTVRSVLNATIA--L---CPGRL----DDASL----- --RTL-----FYEAMAIVNSRP--------LTV------------D-------------- ----------------------GI--------N----DPNSLEPLTPNHL---------- ----------- >R923/1-604 ---PTMRNIYKVVASQYDPLGFLVPYITRAKILIQS-LWAK-Q----------R------ -EWDD-PLLPT--EILKTWHDWQGELQHLS---Q-LTLP--RCY--V------------- -SSQLDS-LNCKR-QVHI-FSDASER-AYG-SVAYLR--SEDL-KG------NVEV-A-- FLTA---------------------------RSRV-APK--R-Q---------------- --------------------------------LSVPRLELCAAL-TGA-QLASLLAKE-- -L------T-LPI---ESF---VL---------WT------------------------- ---------------S---------------KKEEESWFIPHHMV-------SHN----- AKN-RVVFNCSFS-Y-QG---KNLNNLLLPGPALG--SSLLGVLLRFR---EHAV--AFS SDIKGMFHQVRLLPE--DKPLLR-----F------LW-RD---LKRE---------ELPR VYEWQVLPFGTTCSPCCATYA-LQRH------------I----VDH-SQQ---GDNVRHS L-ERC--FYVDNW-LQSVA-T---PDEAKELLDTGM-NL-LAEG-------GFELR-QWA CNFP-NV-IEHL-------SKEARSESSERWL-----------------------NQTES -DPQE-----------------LA--LG-------------------------------- -----LRWMCQSDTLGYQTRLDNCSTPTMRNIYKVVASQYDPLGFL-------------V ----------------------------------------------------------IF KPPFFSTGMDCFGPFT-------------------------------------------- ----------------------------VK--LG-R-----R-SE-----KR-WGI---L -FKCLT--TRAVHIDLLSSLDTDSF-----LMSLRRF-ISRR-GKPSELLSDQGTNFKGG ERELQ-Q-------SFTSMCPT------------------------LQ---KELAKQQIK ----FRFNPPGSPHFGGVWEREIRSVKSALYATVQ--R---Q--SM----TEEVL----- --NTV-----LTEIEGILNSKP--------LGY------------V-------------- ----------------------ST-------------DIADPNPVTPNIL---------- ----------- >R925/1-556 ---ATRRGILSIVASLFDPLGFLAPFVLKGKTILQE-MCRS-G----------M------ -GWDD-N-LPA--DLQSAWEHWKADLVNLE---K-IEVP--RCI--M------------- -PSGFGR--IIRR-EIHH-FSDASMS-GYG-QCSYLR--LENE-QG------DISC-S-- LLMA---------------------------KSRV-APL--K-I---------------- --------------------------------TTIPRLELAAAV-VSV-AVNDMLKEE-- -M------N-LAD---AEA---FF---------WT------------------------- ---------------E---------------GREGERWYIPHHGV-------YHSK-K-P GKL-RIVFDCSAR-Y-KG---TSLNDHLLTGPDLR--NSLTGILLRFR---QYPV--ALM CDVEKMFHQFHVDHA--DRDYLR-----F------LWWRN---GDFN---------SQPQ TFRMTVHLFGASSSPGCANYG-LKHL------------A----REG-ERLY--PLGS-QF I-MQD--FYMDDG-VSSIE-S---TEKAIKLAEEAR-QL-CALG-------SLRLH-KFV SNDK-EV-LKTI-------PPSECAVDVTAVD-----------------------L---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SPPFTYSGMDVFGPFI-------------------------------------------- ----------------------------TC--KG-R-----K-SN-----KR-YGL---L -FTCFC--CRAIHIEMLDDMSTDAF-----INGLRCF-IAIR-GAVHQIRCDQGSNFIGA KNELT-K-------AMEEIDTN-R----------------------LV---TFLAEKQCD ----FVFNAPHSSHTGGVWERQIRTVRSVLRSTLS--Q---SSGRL----DDSSL----- --RTF-----FYEAMSIVNSRP--------LTV------------D-------------- ----------------------SL--------T----DPSSPEPLTPNHL---------- ----------- >R927/1-525 ---HTRRGVLCIVSSIYDPLGFLAPLILPSKLLLQE-LCKR-N----------I------ -GWDS-E-MPQ--TLSRQWSEWLQDLNKIT---M-VKVD--RCI--K------------- -SKDFGM--IRTA-QLHH-FSDASQC-GYG-TVSYLR--LEDE-TK------KVRL-S-- FMLG---------------------------KSRV-APL--K-Q---------------- --------------------------------ITIPRLELAAAV-LAV-RIDLMLRKE-- -L------Q-LDL---DKS---VF---------WT------------------------- -------------------------------------WYIPHHGV-------YHPK-K-- KTI-RVVFDCSAV-F-KG---VSLNSQLLQGPNLT--NTLLGVLTRFR---QEHV--TLM ADIQAMFHQVKVSQK--NVDFLR-----F------LWWPN---GDIT---------KSFK EYRMKVHLFGAISSPTCSNFA-LRKL------------A----ENY-KDCF--PAKALNS I-LHN--FYVDDC-LLSVP-T---EREALQMVKDLT-AV-CSKG-------GFQLC-KWI SNSR-KV-LANI-------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SD LPPFSNTGVDYFGPVD-------------------------------------------- ----------------------------VK--RS-R-----S-VV-----KR-YGV---L -FTCMA--SRAVHLEVAYSLDTDSC-----INCIRRF-MCRR-GQVLQLRSDNGTNFIGA EKELR-N-------ALKSLDHD-K----------------------IQ---RTFLSEGIK ----WIFNTPAGSHHGGVWERLIRLVKKVLHSTLR--Q---Q--CL----DDEGF----- --HTI-----LCEAEAILNDRP--------IIK------------L-------------- ----------------------SD-------------D--------PNDL---------- ----------- >R931/1-532 -----KRIVLRQLASMFDPLGLASPSLLSAKLFFQS-LWT-KE----------N------ -KWDD-K-ISE--EKVKKWKEITDSWAI-N---P-IEIN--RRV--T------------- ------EIKSE-K-QLHV-FSDASKC-AYA-ACVYIK--SQFKEK--------IYT-Q-- ILYA---------------------------RNRL-KPR--K----AE------------ --------------------------------VTIPRMELLGVV-IAK-RALEFVEKQ-- -I------G-VEIK---EK---FL---------WC------------------------- -------------------------------------------PV-------VNT--K-- -KV-RIVYDASAKMR-EG---KSLNECLYRGPIIM--PDLAGLLIRFR---VPKI--AMW ADIEKAFHTLELEEE--DREVTK-----F------IWVKD---T-QK----PRSTQNI-Q YFRFAKVPFGVISSPFLLSAT-VRHH------------L------EKCDD---P-VA-KI A-KEN--SYVDNI-FIGVE-S---TSEAWLAYKTLK-KI-FKDA-------QMNLR-EFV SNDI-EL-NEQFPVEDR--L---------------------------------------- EKNKP-----------------KI--LG-------------------------------- -----IPW---------------------------------------------------- ----------------------------------------------------------RQ SRPFEFVGVDYLGPSI-------------------------------------------- ----------------------------CKI--EGSKV------------KF-WIA---L -FTCLS--TRGIHLDLVTDLSALSF-----LNILRRF-VALR-GAPVKIISDNGNQFIVI AKVIN-A-------IIEGKWKK-EK---TKND-----------EKVFN---NYLIEKEIE ----WKFIPALSPWQGGVYERLVKLVKDCFKRSLG--S-----LIL----NLEEL----- --RTF-----IKEVEMSINCRP--------ISH------------I-------------- ----------------------SV--------E-K------------------------- ----------- >R933/1-557 ---PSKRQMLRTLMSIYDPLGLIAGVLFYLKVLLQE-VWRL-H----------L------ -GWDD-E-VPE--EIQHKWDAWMERLPELE---S-FIIP--RCY--R------------- -QLASLT--ESSL-QLHV-FVDAGAD-GYA-AVAYFR--FEC--HG------RIEV-S-- LVGS---------------------------KAKV-APL--K-Y---------------- --------------------------------LSVPRLELQAAV-MGC-RIASSITSA-- -H------R-ETI---SGS---YF---------WT------------------------- -----------------------------------RKWYLPVFPV-------TNPH-K-P NKV-RLVWDAAAE-V-RG---ISLNKKLLTGPDLL--TPLQAVLFRFR---EYRV--AVA ADIREMYHQVRICDD--DVHSQR-----F------LWRWG---N-TN---------AEPQ EFVMLRMTFGAACSPSTAQFV-KNEN------------A----EKY-RSLY--P-RAVRC I-HEE--HYVDDM-LTSVE-T---EPEAIELAYQVS-LI-HNNA-------GFSLH-NWL SNSI-RV-VTAV--KG---TEST---LKEMDF-----------------------EPC-L KP--E-----------------KV--LG-------------------------------- -----MWWDTTTDSFGFKL----------------------------------------- ----------------------------------------------------------AF SRPFSYTGIDYFGPMV-------------------------------------------- ----------------------------IV--NG-R-----K-TE-----KR-WGV---L -FTCLT--VRAVHIELVQSLSTSDC-----LMAVRSF-MARR-GTPIEIVSDRGTNFVGA DRELK-E-------AAERVD-S-A----------------------IL---NEFGSPDPV ----WKFNPPAAPHFGGSWERMIQSVKRMLSRTLT------E-RHP----TEAVL----- --SAA-----LIEVENMLNSRP--------LTH------------V-------------- ----------------------PV-------------DG--------------------- ----------- >R934/1-550 -----KRGVLSVIARIFDPLGFLSPVIFHAKCIMQR-LWSA-Q----------T------ -SWDE-P-LPP--AIAKEWQQFLDMLGWLT---E-IRIP--RCI--G------------- --GSIG-----IEYSLCG-FCDASER-GYA-AVLYLR--VTDP-SQ------KVNV-Y-- LLGA---------------------------KTKL-TSL-------K------------- ---P----------------------------TTIPRLELCGAV-LLA-SWLSRMHRI-- -L------E-A-H---MKISGVYA---------WS------------------------- -----------------------------------GDYYIPHHAV-------YKAE-GEN MKL-RVVFDASARCR-SG---SSLNEGLHVGPKLQ--QDIVDVLTGFR---VHTV--AFT TDICKMYRQIWVLEK--YRGYQH-----I------LWRSS---P-QL---------QI-R ENTLNTVTYGVNSAPYLALRV-LRHI------------A----DND-CEEV--P-EVSKA L-KFQ--TYMDDI-CVGAP-S---LECALSLKSDLI-KT-LSRS-------GLMLK-KWS SNEP-RL-LSGLPLEDLAGDP-----LTFD------------------------------ RGDGI-----------------PV--LG-------------------------------- -----MQW---------------------------------------------------- ----------------------------------------------------------QA CRAFTAVGIDYAGPLM-------------------------------------------- ----------------------------MKET--KLRK---AREY-----KV-YIA---L -FVCMS--TRAIHLEVVLDLSTDAF-----LAALDRF-VVRR-GVPTSIHSDCGTNFVGA ARKLR-E----------LINSP-SS------------------RDQCS---SRLM---CH ----WNFNPPSAPHFGGLWEAAVKSTKSLLTRSLG--A-----QTW----TLEEF----- --TTI-----LCRVEAALNSRP--------LTP------------V-------------- ----------------------TS--------D-----------------PEDL------ ----------- >R935/1-508 ---ATKRSVLSELAQVFDPLGFLSPLLILGKIFVQE-LWLL-K----------Q------ -DWDE-E-LPA--SYATQWLRYREELKLID---K-ISIP---SS--I------------- -PITAD-PC--TL-QLFG-FSDASNR-AYG-GVIYAR--VRDE-GG------GISV-R-- LVTA---------------------------KSKV-APV-------R------------- ---V----------------------------TSLPRLQLQGAL-LVA-KLMAKV-AC-- -L-H----I-A-V---EKV---NY---------FT------------------------- --------------------------------------FMPHHPV-------IRPE-SLT TKL-RVVFDASCRSS-NG---RPLNEANLVGPTLQ--PDLFETLTRFR---FYRY--ALT ADIKKMYRQILVAEP--HRNYQC-----I------LWRCN---V-SD---------PI-Q VLRLNTVTYGTNSAPFLAVRC-LYYL------------V----DRY-AEKF--P-LAREA V-KRS--FYMDDM-LCGAE-S---KEELTKLKEQVT-EL-LGLG-------KFELH-KWR SNY--------------------------------------------------------- --------------------------QG-------------------------------- -----MDN---------------------------------------------------- ----------------------------------------------------------GN IYPFERAGLDFAGPIW-------------------------------------------- ----------------------------MHFH--MRGK---RPV------KV-YLC---I -FVCFA--TKACHIEIVSDLSSNAF-----IAALKRF-FARR-GLSSDLYCDNATNFVGH ESSTE-------------LSTR-QVR-----------------SSLTT---NAASEES-- -----GFT--SSPHAPLTLEDYGR-APRWPNSCLN--A-----PT--------------- --AQH-----TTKILLPSHKKR--------ILD------------L-------------- ----------------------CI---------PC--H-------R-------------- ----------- >R937/1-571 ---STKRKILGQIAHIFDPIGFAAPVIVRAKIGMQK-LWQR-G----------Y------ -NWDD-H-LSP--EEDAEWRLLFEEMKGLN---K-VSLE--RCL--T------------- -LPDAQG----QP-VLCI-FSDASEN-AYG-ACAYLR--WQTR-DD------RYET-R-- FIAS---------------------------KSKV-APL--K-A---------------- --------------------------------LTIPRFVLQAAV-LAA-RLYKSITEE-- -M------R-LEV---EKV---VL---------FT------------------------- -------------------------------------------------------E-KKS TPI-RIVFNSSAS-F-QV---HRLNEYWVKGPDLL--NNLIGVLLRFR---ENEV--ALC GDISKMYHRVSIPER--DQHVHR-----F------LWRDM---D--E---------HRPD IYMMKVVTFGDNPAPAIAHTA-HKLT------------A----EQG-ESTH--PQAA-TV L-KRI--LYMDDI-CDFVR-T---VDEARKLSAEMD-EV-LNEG-------GFKVK-GWI SNES-DV-GDLTQGKMKLLDEIAEEKVLGVVWDRENDTFSYKVTLKDSVVKSATDGESEE KSTKR-----------------KI--LG-------------------------------- -----QIA---------------------------------------------------- ----------------------------------------------------------PH TPPFYYTSCDYFGPFQ-------------------------------------------- ----------------------------VK--VG-R-----NKRA-----KH-YGV---I -FTCLN--TRAVHLEIATDCSTMEF-----LHVLRRF-FAVR-GQPAQILSDNGTQFVGA QRELR-E-------MISGWSED-E----------------------LK---DFCAEKRVQ ----WKFITPGAPHQNGCAESLVKSAKIAIKKAIG--E-----QVL----TPFEL----- --LTC-----FLEVANFMNERP--------IGR------------K-------------- ----------------------CN-------------DPGDG------------------ ----------- >R943/1-564 ---PTRRGLLSVIASLYDPLGFVAPFTLSGKHILQE-LCCR-G----------I------ -GWDD-P-IPE--NLRSRWEEWKNGLQRLK---E-IAIP--RCY--Y------------- -PQNFGE--IVRV-ELHH-FADASNA-GYG-SCSYLR--YQNN-RN------EIHC-S-- FVMA---------------------------KARV-APT--K-I---------------- --------------------------------TSIPRLELSAAV-TAA-RMSVMLKAE-- -L------E-MKI---EQE---FF---------CT------------------------- -------------------------------------WYIPHHGV-------YNPK-K-P DKL-RIVFDCSAK-F-RG---ISLNDTLLTGPDLI--NPLLGVLCRFR---REAV--AVI CDIERMFHQFSVSPE--VRNYLR-----F------LWWEG---GLFE---------REPQ EYRITVHLFGAASSPGCANVC-LKYL------------A----QQH-KVNY--PAAS-AF L-ENN--FYVDDG-LTSVP-T---VKEAKKLIVETQ-EL-CKGA-------GLRLH-KFN SNQS-EV-LSCV-------ASSERAVNTDPLN-----------------------LKPYP -AAGA-----------------HI--LG-------------------------------- -----IQW---------------------------------------------------- ----------------------------------------------------------EV SAPFTFCGMDCFGPFV-------------------------------------------- ----------------------------TK--RG-R-----K-EY-----KR-YGL---I -FTCLS--SRAIHLEMLDDLSTDVF-----INALRCF-ISLR-GAVSHLRCDQGTNFVGA KNEFK-E-------APKQCDTE-A----------------------LK---AFLADKQCE ----FTFNAPSASHAGGVWERQIRTIRSVLNVTVA--Q---CSGRL----DDASL----- --RTL-----FYEAMAIVNSRP--------LNV------------D-------------- ----------------------GI--------N----DPMAPEPLTPNHL---------- ----------- >R945/1-582 ---FSRRGVLSTVASIYDPLGFVAPFVLLGKQILQQ-MCRD-K----------S------ -DWDT-P-LSN--EHQSRWESWLTDLKDLA---H-VKID--RCY--L------------- -PADFQE--VQRY-ELHH-FSDASVA-GYG-VCTYLR--AVSR-SG------RIHC-S-- LVIA---------------------------KSRV-APT--K-V---------------- --------------------------------TTVPRLELSAAV-VAV-RISDMLKGE-- -L------E-LEN---VQE---FF---------WT------------------------- ---------------E---------------LDKSSTWYLPHHGV-------YHPQ-K-P GKI-RVVFDCSAK-F-KG---VSLNDHLLTGPELT--NTLIGVLCRFR---KGPV--AVM CDIERMFHQFRVRDE--DQDYLR-----F------LWWDN---GDFH---------LSPS VYRMRVHLFGAASSPACANFG-LKYI------------A----AQG-RGQF--SEATIRF I-ERN--FYVDDG-LISFH-S---EEEAIRLVHEAK-KL-CSIG-------KLRLH-KFV SNSP-QV-LESL-------PKEDCVETVRNQD-----------------------LALGE -QLIE-----------------RA--LG-------------------------------- -----VKWSVASDHFQFRVVVS-------------------------------------- ----------------------------------------------------------ET TPPFTYCGMDCFGPFY-------------------------------------------- ----------------------------IK--EG-R-----R-EL-----KR-YGL---L -FTCLC--SRAVHIELLDDLSTDAF-----LNSLRAF-IALR-GNVRQLQSDQGTNFVGA RREFL-E-------AVKEMDQE-C----------------------LK---QL----GCE ----FVMNPPSASHMGGAWERQIRTIRSVLNSILD--Q---SSRTL----DSSSL----- --RTY-----LYEVMAIVNSRP--------ITT------------Q-------------- ----------------------LL--------N----DPTGPQPLTPNLL---------- ----------- >R947/1-539 ---MTRRGVLSTVASVYDPLGFVAPFLLVGKQILQV-LCKD-K----------V------ -SWDE-D-LPE--HILPQWESWLRDLPHLA---D-LKIP--RSY--L------------- -SSNFDR--PVSY-ELHS-FSDASLS-GYG-ACSYLR--ATSE-TG------QISC-S-- LVIG---------------------------KARV-TPT--K-Q---------------- --------------------------------TTIPRLELSAAV-TSV-RNGNIVKRE-- -L------E-IED---LQE---YY---------WT------------------------- ---------------E---------------LDNKSAWYIPHHGV-------YHPH-K-P GKI-RVVFDCSAR-F-QE---ASLNDHLLTGPDLT--NTLVGVLCRFR---KGPI--AIM CDIERMFHQFHVTKE--HQDYLR-----F------LWWDN---GNLD---------SKPS VYRMRVHLFGAASSPGCSNFG-LKYL------------A----SQG-HGSF--SEEAIKF I-QRS--FYVDDG-LTSVS-T---SAEAIHLVDEAR-AL-CKTG-------NLRLH-KFV SNDM-EV-IATI------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ET SPPFTCCGIDCFGPFI-------------------------------------------- ----------------------------VK--EG-R-----K-EL-----KR-YGL---L -FTCLC--SRAVHIETLDDLTTDSF-----INALRVF-VAIR-GPVRQIRCDQGTNFMGA RREFS-D-------LLRGMDQE-R----------------------VR---AI----GCE ----FVVNVPSASHMGGVWERQIRTIRSILNAMLD--G---SACRL----DSTTL----- --RTF-----LYETMAIINSRP--------LSV------------E-------------- ----------------------HL--------H----DPTGPEPLTPNHI---------- ----------- >R949/1-567 ---YTRRGLLSVVNSLYDPLGFVAPITVQGKLLLRE-LTAN-A----------T------ -DWDS-P-LPA--SGQELWDSWKNSLQELQ---H-IQVP--RSY--G------------- -LVSPSG--AKFT-ELSV-FSDASEK-IIA-AVAYLK--TVDS-NG------NCHA-G-- FITG---------------------------KARL-APL--P-E---------------- --------------------------------LSIPRLELCAAV-LSV-NMMETIIAE-- -I------A-IRF---DEI---NL---------YT------------------------- -------------------------------------WYLPSFGV-------YHPK-K-P SQM-RVVFDSSAL-Y-KG---VSLNKVLLTGPDLN--NSLLGVLMRFR---KEPV--AFM VDIQQMFHCFRVRPA--DRNYLR-----F------LWFHE---NNPE---------NELT EYSMKVHVFGNSPSPAVAIYC-LRCA------------A----QEG-ETDF--GEDARQF V-EED--FYMDDG-LKSLP-S---PEMAISLLKRTQ-DM-LAGS-------NLKLH-KLA SNSK-KV-MQAF-------SSEDYANSLKELD-----------------------LGVNS -LPMQ-----------------RT--LG-------------------------------- -----LLWNLETDCFNFQV----------------------------------------- ----------------------------------------------------------SA EPPFTHVGLDVFGPWS-------------------------------------------- ----------------------------VC--AR-RTRGGFA-ES-----KR-WAV---L -FTCLN--IRAIHIEVIESLTTSSF-----INALRRF-LAIR-GPVKQIRSDRGTNFIGA CKDLQ-I-------PSN-VDEK-A----------------------VE---RFLSDHNCT ----WTFNPPHSSHMGGTWERIIGLTRKILDSMLL--QT--SSSRL----THEVL----- --STF-----MAEVTVIINNRP--------L--------------I-------------- ----------------------PV-------------ST--------------------- ----------- >R951/1-593 ---FTRRGILSTVNSLYDPLGFVCPITMQGRALVRE-LSTI-Q----------Q------ -DWDT-I-LPL--EKESSWKAWISSLAELD---Q-LQIP--QAY--V------------- -PTSVCR--APLC-ELCI-FSDASTL-AIA-AVAYLR--VIDS-NG------QPHV-G-- FVMG---------------------------RSKL-APF--P-A---------------- --------------------------------HTVPRLELCAAV-LAV-ELMEFIKGE-- -I------D-LEL---HDI---HF---------YT------------------------- -----------------------------------ECWYLPIFGV-------YHPH-K-P DKI-RVVFDSSAQ-F-RG---VSLNDVLLSGPDLN--NTLLGVLLRFR---REKI--AVM ADIEQMFYCFKVKEP--HRNYLR-----F------LWDKD---NCPE---------KEII DYRMTVHVFGNSPSPAVAIYA-LRQA------------A----EHG-KVEC--GTDAKNF V-LRN--FYVDDG-ITSVP-T---EREAIDLLKRTQ-TM-LSKS-------SLNLH-KVA SNSA-SV-MEAF-------PSSERAKDLKDLD-----------------------FSKDT -IPLQ-----------------HS--LG-------------------------------- -----ISWNLKTDCFMFKASQECKPFTRRGILSTVNSLYDPLGFVC-------------- ----------------------------------------------------------SV DPPFTYTGLDVFGPFT-------------------------------------------- ----------------------------VV--TR-KTRGHNI-EN-----KR-WAV---I -FSCLS--SRAVHLEVMESLSASSF-----ICALRRF-LAVR-GPVKHFRSDRGTNFVGA VKELQ-I-------D---SGDS-E----------------------LK---GFLQNQSCT ----WTFNAPHSSHMGGVWERMIGIARRILEALLI--KS--A-TRL----THEVL----- --TTL-----MAEVMAIMNSRP--------L--------------T-------------- ----------------------PI-------------ST--------------------- ----------- >R953/1-565 ---FTRRGILSTVNSLYDPLGFVASVTIQGKALVRE-LSSD-Q----------V------ -DWDT-P-LPT--DKETQWKVWTNSLADLR---K-VQIP--RPY--I------------- -PISMSQ--TSER-EVII-FSDASTL-AIA-AVAYLR--VASI-EG------QCHV-G-- FIMA---------------------------KSKL-AQY--P-A---------------- --------------------------------QTVPRLELCAAV-LAV-ELAELITEE-- -L------D-MEL---TTV---KF---------YT------------------------- -------------------------------------WYLPIFGV-------YHPL-K-P GKI-RVVFDSSAQ-C-KG---ISLNDTLLRGPDLN--NKLLGVLMRFR---KEQV--AVT ADVEQMFYCFKVRKD--HQNFLR-----F------LWFKD---NDLS---------KEIT EYRMSVHVFGNSPSPAVAIYG-LRRA------------A----DWG-EEEY--GEEAKQF I-HRN--FYVDDG-LISVS-S---AAEAISLLKNTK-NM-LSES-------NIRLH-KIS SNSH-QV-MEAF-------PASDRANDLKDLD-----------------------LTIDP -LPLQ-----------------RS--LG-------------------------------- -----VSWSLETDCLTFQV----------------------------------------- ----------------------------------------------------------TV DPPSTYVGLDVFGPWS-------------------------------------------- ----------------------------IM--SR-RTRGGSA-ES-----KR-WAV---I -FSCLS--TRAVHLEVIESMSTSSF-----INALRRF-LAVR-GPVKHLRSDRGTNFIGA CRELN-I-------K---TDDP-E----------------------LK---GYLQEQGCT ----WSFNVPHSSHMGGAWERMINTARCILDGLLL--KS--SCTRL----THEVL----- --TTL-----MSEVMAIMNARP--------L--------------I-------------- ----------------------PI-------------SS--------------------- ----------- >R955/1-550 ---FTRRGVLSTVNSVFDPLGLLAPVTIQGRALLRE-LTSE-S----------A------ -DWDT-S-LPE--VKLNKWVAWRSSLQELE---K-LHVS--RTY--T------------- -KTSLTE--AVHT-ELCV-FSDASTK-AIG-AVAYLK--VLQK-DG------QVEV-G-- FVMG---------------------------KAKL-APL--S-E---------------- --------------------------------PTIPRLELCAAV-LAV-EMADLIKDE-- -L------D-LEL---NDI---RF---------FT------------------------- -------------------------------------WYLPTFGV-------YHPQ-K-P NQI-RVVFDSSAC-Y-SG---VSLNDVLLTGPDLN--NSLVGVLLRFR---KERV--AIL ADIQQMFHCFLVRDD--HRNFLR-----F------LWYKD---NDVN---------KEII EYRMNVHVFGNRPSPAVAIYG-LRRA------------I----REG-AKDH--GEDTIKF V-ERH--FYVDDG-VVSVP-S---EAEAIDLLQRTQ-AS-LAES-------NLRLH-KFA SNSQ-IV-MKAF-------PPEDCAPVIKDLD-----------------------LSGET -SPTQ-----------------RS--LG-------------------------------- -----LLW---------------------------------------------------- ----------------------------------------------------------KI CPPFTYVGLDVFGPWS-------------------------------------------- ----------------------------VT--TR-RTRGGQA-ES-----KR-WAI---M -FGCMS--SRAVHIEVIESMDASSC-----INALRRF-FALR-GPAKQLRSDCGTNFVGA CKELG-M-------DK-------M----------------------VQ---RYLSEQGCS ----WEFNPPHSSHMGGSWERLIGIARRILDSMFL--QL--K-ARL----THEVL----- --CTL-----LAEVTAIINARP--------L--------------L-------------- ----------------------PV-------------SA--------------------- ----------- >R957/1-574 ----TRRGISATVSSVYDPLAFTAPVMLEPKLILQQ-LCRE-K----------A------ -DWDD-D-VPE--NIRSRWEKWRY-LKGFR---E-VEVQ--RCY--E------------- -PPEFGT--VVTR-ELHY-FSDASTV-GYG-QCTYLR--IVNS-QQ------QVHC-A-- FVSG---------------------------KSRV-APL--K-Q---------------- --------------------------------ITIPRLELTAAV-ISA-QVSAYLKQQ-- -L------Y-FEN---CRE---YF---------WV------------------------- ---------------NVIKLFDKSVDKPSMYENTNRINYIPHTGK-------HYSK-K-- ENL-RVLFDYAAE-Y-PG---ISLNDYLLQGPDML--NSLVGILCRFR---LHRT--AII ADIEAMFHQFKVEKP--YRDLLR-----F------LWWKN---GDLE---------KPIV EYRMKVHIFGAVSSPGCANYG-LRKA------------A----DDG-EAEF--GIEAANY L-RKN--FYVDDG-VISVP-T---TENAIALIKDSK-AL-CAKA-------GLRL--KFA SNDR--V-LKQI-------PLSDRSKSLRDIQ-----------------------IGIHR -LPRE-----------------RV--LG-------------------------------- -----ITW---------------------------------------------------- ----------------------------------------------------------HE CPPFSYCGVDYFGPFY-------------------------------------------- ----------------------------IK--EK-R-----S-MI-----KR-YGV---L -FTCLV--SRAIHLETSNTLNTDSF-----INALRRF-LARR-CPVLQMRSDCGTNFVGA FNELK-S-------EAGSINQE-S----------------------IK---QYLLRQDCD -WVPFEFNPPHASHMGGVWERQIRTVRSSLELMLR--R---FGEQL----DDETF----- --RTL-----MTEVENIVNSRP--------LTH------------S-------------- ----------------------GL--------N----EA--------------------- ----------- >R959/1-538 ----TKRNALSDVAKLFDPIGLVGPVIIQAKLFLQE-LWRC-Q----------I------ -AWDE-P-LTP--ALQNRWLLFREKLAMLQ---T-IHIP--RWL--L------------- --TDQR-AT--NL-QMHC-FCDASEK-AYG-AAIYLR--STNT-DG------RVTT-N-- LITA---------------------------KSKV-APL--A-DSRK------------- ---QKR--------------------------VCLPRLELSAAL-LLA-HSYEKVSDA-- -L-K----L---Q---VET---IF---------WS------------------------- -----------------------------------PSYYLPHHCI-------VRPD-STT TKL-RVVFDASCASD-TG---TSLNDALMIGPTIQ--DDLMSILLRFR---MSKF--ALV ADIEKMYRQINIAAI--DRPLQR-----I------LWRNS---P-TE---------PI-R TFQLNTVTYGTSCAPYLATKT-LQVL------------S----QVG-ASTH--P-EAATI L-GRD--FYMDDM-LTGVN-S---IPEGQRVCQQLI-DL-LASG-------GFCLR-KWA TNNR-QI-FEHLPQHL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP TSTFLHTGVDLCGPIH-------------------------------------------- ----------------------------YRHT--SRKA---QLI------KG-YVA---I -FVCMA--VKAVHIELVADLSTNAF-----LAALRRF-IGRR-GKPAIIECDNARNFLGA SREIA-S-------LSKQF-NH-QW------------------QTSVI---KSCIDDGIQ ----FKFIPPRSPNFGGLWEAAVKSFKTHFKPTVG--N-----AIL----TSDEL----- --NTL-----LIQIEGCLNSRP--------LTP------------L-------------- ----------------------SN--------DPS--D-------L-------------- ----------- >R960/1-530 ---PTKRAILSEIAAIFDPLGLISPVIICFKIIMQK-IWQT-R----------V------ -DWDA-T-LPT--EIEGEWRKCRANLIHLN---T-LKIT--RSL--V------------- --VDGD-IA--DI-QLHG-FADASLT-AYG-ACLYLR--VKNY-NG------EVIA-N-- LICS---------------------------KSRV-APL-------K------------- ---T----------------------------ISLPRLELLAAV-LLV-RLAAKYATS-- -L-S----I-P-I---EHK---YF---------WS------------------------- ---------------------------------------LPHHAV-------RNES-STS TKL-RVVFDASARTS-TN---ESLNDVLLKGPTVQ--EDLVSIMTRFR---IHKY--VFT ADIKKMYQQIWVSES--QRDFQR-----I------LWRED---P-SQ---------PL-N VYRLKTVTYGIVTASYLATAC-LQKL------------S----EQE-SSKF--P-EACQA L-SCD--FYVDDF-LGGAM-S---KQSALRLRDDLI-TI-LRGA-------GLELC-KWS SNDP-DL-L--------------------------------------------------- --------------------------LG-------------------------------- -----VEA---------------------------------------------------- ----------------------------------------------------------RP TRAFKKTGVDFAGPFM-------------------------------------------- ----------------------------IKSS--LRRN---APLN-----KV-YAC---L -FVCFI--TKAVHVELVGDLTTQAF-----LNALQRF-CDRR-GLCTDIYSDNATNFVGA NRQLQ-E-------LQALFQST-EH------------------QERIQ---DTLSKSSIQ ----WHFIPPRSPHFGGLWEAAVKSLKAHLYRTLG--N-----ASL----TFEEL----- --NTI-----LIRVEAILNSRP--------LTP------------L-------------- ----------------------SS--------HPS--D-------L-------------- ----------- >R961/1-527 ----TRRHLLSQVAGLYDPVGLVTPAKQKGAILVRK-AFQETG----------KGSL-TR ETWDM-P-LSE--NLREEAIRLFEEYVQLN---Q-VKFH--RSL--T------------- -PPGWKGKPWGIT------FSDGSDK-TYG-AVLYLR--WNTD-QG-------IDV-R-- LVES---------------------------KAKL-TPLDQK------------------ --------------------------------GDAVKAEICGAV-FAA-RLRKYFEKH-- --------GRMEV---ERW---FH---------LV------------------------- ----------------------------------------------------PNPH-STT TPV-RLVWNSSQK-F-KG---LSMNDLLLKGPDVL--NPIRAVLLRFR---KGVF--AAL GDIKKMYNSVWLEER--EVHLHR-----F------LWRDT---Q-DE---------EISE -YAITRVNIGDRPAGCIAQLA-MRET------------A----RLA-KFAH--LKEECRV L-EED--SYVDDI-LTSHN-S---QERLKEITNGLE-EI-LAAG-------GFALK-PWV RSEQ-SG-RNE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP AAPFEYTTLDLFGPYI-------------------------------------------- ----------------------------VKDEVRKRVHL-----------KV-WGI---V -YCCMA--SRAIHTDIVSDQSAEGF-----MLAYQRF-TALR-GHPRKLWSDPGSNFIGV KPALT-E-------LYKFLDKL--------------------ETSELE---EKAAKHGTE --WVWKIHPASSPHRNGAAEAAVRIVKRALHNLGG--D-----GVF----TWSEF----- --QTF-----LYMAANLANERP--------IDA------------R-------------- ----------------------TQSREDC------------------------------- ----------- >R968/1-605 ----TCRGILSTISSVYDPLSFIGPVMLEGKLVLQQ-LCRD-K----------A------ -DWDD-I-LPS--DLQVRWEKWRTEMQSLE---Q-IQIK--RVF--H------------- -PKGFGK--VQKL-EMHH-FSDASNV-GCG-QCSYVR--LVNE-NH------DVCC-A-- LVMG---------------------------KSRV-APL--K-P---------------- --------------------------------VTIPRLELVAAV-LSA-KVSKYLGEH-- -L------P-WEK---RKD---YF---------WT------------------------- --------------------------------------YIPHTGI-------YNQH-K-P GKI-RVVFDCAAR-F-GG---LCLNDVLLQGPDLM--NDLVGILCRFR---RHDI--AVT ADIQGMFHQFFVEAK--YRDLLR-----F------LWWED---GNID---------NPIT EYRMKVHIFGAVSSPACANFG-LRRA------------A----DDG-ELKY--RKDAADF V-RND--FYVDDG-ITSVS-D---RATAISLIKRSK-SL-CAEA-------GLRLH-KFT SNDR-IV-LDSI-------PEEDRANSVQRID-----------------------IYKNP -LPVE-----------------RI--LG-------------------------------- -----IYWCIENDSFQFRLIMKDVPLTCRGILSTISSVYDPLSFIGPVM----------- ----------------------------------------------------------YQ GPPFTYCGVDYFGPFL-------------------------------------------- ----------------------------IK--DK-R-----S-IV-----KS-YGV---L -FTCMS--SRAIHIETAISMDTSSC-----INALRRF-LARR-GPVVQIRCDCGTNLVGA NDELT-A-------NC-IINQQ-E----------------------LR---QFLLRQECD -MVEFNFNAPHASHMGGVWERQIRTVRSVLGTLLF--Q---YGQQL----DDETF----- --RTF-----MTEVENIVNS-P--------LTI------------A-------------- ----------------------SM--------T----DAGCPEPLTPNHI---------- ----------- >R971/1-546 ----TRRGILSTISSIYDPLGMLSPVILTAKKVLRD-LCRR-E----------I------ -GWDD-T-VPE--SVSKDWMKWLQQLHLLD---V-FKVD--RCV--K------------- -PSCFGD--VVTA-QLHH-FSDASQD-GYG-TVSYLL--LKNQ-HS------VMHS-A-- FIMG---------------------------KARV-APL--K-S---------------- --------------------------------VTIPRMELIAAT-MAS-RMDILWRKE-- -M------H-MDL---LDS---VF---------WT------------------------- ---------------D---------------RSDGKVWYIPHHGV-------FHPT-K-- GKM-RVVFDCAAS-Y-QG---TSLNAQLLQGPDLT--SSLIGVMTRFR---KEPV--VIM ADVESMFYQVRVSSD--YSDLLR-----F------LWWPN---GDVE---------QQPV EYRMKVHLFGAASSPSCANYA-LRRC------------A----EDY-GCHY--SENAVDK L-LNS--FYVDDC-LVSVV-T---EKEAVSLYQELV-SL-CARG-------GFSLT-KWI TNRP-GV-LEAI-------PESHRARGMEGLN-----------------------ME--- ------------------------------------------------------------ -------L---------------------------------------------------- ----------------------------------------------------------PD EPPFTRVGVDYFGPFE-------------------------------------------- ----------------------------VK--SR-R-----S-MV-----KR-YGV---I -FTCLA--IRAVHLEVAPSLDTDSF-----INALRRF-ISRR-GQVREIRSDNGTNFVGA ERELK-A-------AIKQWNQG-Q----------------------IN---DLLLQKGIR ----WSFNPPAGSHHGGSWERLIRSVRKVLNSMFK--V---Q--NL----DEEGL----- --HTV-----LCEIEAIINSRP--------ITK------------A-------------- ----------------------SM-------------D--------PNDL---------- ----------- >R976/1-550 ---PTRRGILSMVSQVYDPLGFAQPFILPAKKLLQV-ACHN-R----------L------ -SWDE-P-VSS--EQRETWDDWLQTLEGLQ---A-ISIP--RCF--R------------- -PPY--E--VHQI-QLHL-FCDASKL-GYG-AVGYCR--MVDE-NR------KVHC-S-- FVMG---------------------------KSRV-API--S-P---------------- --------------------------------VSVPRLELTSAV-TAV-RLAALIKTE-- -L------E-YDI---HDV---VY---------WT------------------------- ---------------S-----------------SNAIWYIPHHCT-------G------- PKF-RVVFDCAAC-F-NG---VCLNDNLLQGPDLT--NNLVGVLLRFR---QERV--ALV ADIKGMFHQVLVDPK--DRDALR-----F------LWWPD---DDMD---------KEPV DHRMNVHIFGATSSPSCSSFA-LMRT------------A----QEN-ETGA--DEITTRT V-RRN--FYVDDL-LKSCR-S---VDEMLKLVAQIV-PL-LASG-------GFHLT-KFL TNEK-RV-LSSI-------PVDDIASSMLTID-----------------------LHGLP ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AG SPPFTAVGVDYMGPIL-------------------------------------------- ----------------------------TK--LG-R-----S-QV-----KR-YGC---I -FTCMA--TRAIHIEVAESLETSAF-----IGAYRRF-TCRRIGRPKQIFSDNGTNLVGA ERELR-E-------GIRNWNIK-Q----------------------MH---DAFLQDEIS ----WNFNPPAASHQGGVWERMIRSVRKVMRSING--E---K--VL----DDFGL----- --LTL-----MAEIERILNDRP--------ITP------------I-------------- ----------------------SD-------------DHRDELALTPSML---------- ----------- >R978/1-562 ---PTKREVLSAIAKIFDPLGLISPVVVLAKILMQK-LWLA-K----------L------ -DWDD-Q-ISE--PLIEEWDNFLEALPTEN---Q-VRIP--RHV--V------------- --ST-N-AV--SL-EIHG-FADASLK-AYG-ACVYIR--SIER-NG------EAQL-R-- LVIS---------------------------KSRV-APL-------S------------- ---N----------------------------VTIPRMELLAAS-LLC-RLVKKVLEA-- -LKD----F-N-F---ETI---NL---------WS------------------------- ------------------------------DDGSVKRWYLPHHAV-------LNPA-KNT TKC-RVVFDASAKV--NG---LSLNDVMMTGPKVQ--HDLLSIKLRFR---MPRY--VVS ADISKMFRQIKVDPC--DSPLQR-----V------FWRAS---P-NE---------QL-R VLELTTVTYGTAAAPFLATRT-LLQL------------A----RDE-REGF--P-LASRI I-EEN--FYVDDG-LFGAN-D---IETVHAAQVQLI-EV-FRKA-------GMTLH-KWS ANDE-RL-LESIPFEDRDALT------KIG---------------------------DCE ANEII-----------------KT--LG-------------------------------- -----LMW---------------------------------------------------- ----------------------------------------------------------TA APTFQRVGLDFAGPIM-------------------------------------------- ----------------------------LK--SGIRRV---AAI------KG-YIC---V -FVCMV--TKAIHLEAVEDLSTGAF-----LSALRRF-VSRR-GIPEEIFSDNATNFVGA KNELR-E-------LYEMFRKE-AT------------------GQGIF---QFCQEKEIV ----WKMIPPGAPHFGGIWEAGVKSVKSVLKKIYK--S-----ASL----TITDF----- --STL-----LCQIEAILNSRP--------LYA------------H-------------- ----------------------SN--------D-----------------PNDL------ ----------- >R981/1-556 ----TMRTAYQILATQYDPLGFIVPFTTRAKVLIQQ-LWSK-K----------R------ -DWDD-PNLPQ--DLSRAWETWENELKHLS---D-ITIP--RCYSSI------------- -PHDAQQ----QY-ELHV-FCDASER-AYG-AVAYL---VE-Y-AD------VIHS-T-- FVMP---------------------------RSRI-APK--R-Q---------------- --------------------------------QSIPRLELCAAL-AGA-QLAKLLKEE-- -I------T-LKI---QQI---VL---------WT------------------------- -----------------------------------EAWYIPHHLV-------CHN----- DKP-RLVFNCSFR-S-QG---QSLNDQLLPGPALG--PSLLGVLLRFR---QYNV--AVS ADIRGMFHQVRLLPE--DRPLLR-----F------IW-RD---LQYE---------NCPD VYEWQVLPFGTTSSPCCAIFA-VQQH------------A----RNN-QES---YPSALQT I-QQS--FYVDNY-LASFP-T---TSEARVSVDQLR-SL-LATG-------GFDLR-PWA SNQP-AV-ISHL-------PTEARSSAAEQWL-----------------------AQNRT -DPME-----------------PT--LG-------------------------------- -----LRWNCAADTLGYHY----------------------------------------- ----------------------------------------------------------IL CPPFYSTGVDCFGPYQ-------------------------------------------- ----------------------------VK--IG-R-----R-VE-----KR-LGV---I -FKCLT--TRAVHIELLNSMDVDAF-----LLALRRF-IARR-GRPKELRSDCGTNFRGA DRELR-E-------AFAAMESP------------------------LK---ERLADHQIT ----FKFNPPHAPHFGGTWEREVRSIKTALRAAVG--G---Q--SV----SEDVL----- --TTV-----LVEVEGILNSKP--------LGY------------A-------------- ----------------------ST-------------DI--------------------- ----------- >R984/1-538 ---STKRSILSSIAKMYDPLGLIAPVIVRAKMLMQE-LWLL-K----------S------ -GWDE-P-VPN--HICKKWKAIQSDWKTLS---E-YRTN--RYA--L------------- --LP-D-AT---V-EFHT-FTDASEA-AYG-ACVYAR--CENA-AG------EVRI-S-- LLAS---------------------------KSRV-APL-------K------------- ---R----------------------------VTLPRLELSAAV-LGA-HLHHRVKEA-- -M-Q----I-V-C---AES---FF---------WS------------------------- -----------------------------------RAYYLPHHPV-------FKAS-STT TKV-RVVFDGSAKTS-TG---YSLNDILCVGPIVQ--DELLDIVLRFR---TYQI--ALV GDIAKMYRQILLHSD--DRRLVR-----I------FFRFS---P-QA---------PI-Q VYELNTVTYGLAPSSFLATRT-LIQL------------A----DDE-GTEY--A-LAPAA L-KRN--FYVDDF-IGGAN-N---VREAVQLRKELS-AL-LAKG-------GFELR-KWT SNNL-SV-LSGLSTEYIGTHS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP SRPFSVTGVDYAGPFY-------------------------------------------- ----------------------------LKPA--HRKA---AAT------KS-YLC---V -FVCFA--TKAVHLELVGDLTTAGF-----LAALRRF-TSRR-GLPAHIHSDNGKNFEGA ERELK-E-------LFELFNDE-QH------------------RNTVA---TRCADRGIT ----WHFNPPKAPHFGGLWEAAVKTAKRHLYRHLG--N-----TRL----SYEGY----- --CTV-----LHQIEAAMNSRP--------LLP------------L-------------- ----------------------SD--------DPN--E-------L-------------- ----------- >R985/1-575 ---FTRRGVLSTIASVFDPLGFMAPFILVGKKILQQ-LCYN-K----------A------ -SWDD-S-LPE--DLQSRWERWLLDLPNLA---D-VKIP--RCY--V------------- -PQISNE--AIRF-ELHH-FSDASIS-GYG-ECSYLR--TVSA-SG------EVHC-S-- FVMG---------------------------KSRV-APT--K-I---------------- --------------------------------TTIPRLELSAAV-VAV-RVSDMLKKE-- -L------D-IKD---LQE---CF---------WI------------------------- -------------------------------------WYIPHHGV-------YHPK-K-P GKI-RVVFDCSAR-F-QG---TSLNDHLLTGPELT--NTLVGVLCRFR---KNPV--AIM CDIERMFHQFHVKAE--DRDYLR-----F------LWWDN---GNLE---------AQPS VYKMKVHLFGAASSPGCANYG-LKHL------------A----AEG-KGMF--TEDVIRF I-QRN--FYVDDG-LVSVP-T---EAEAIALVTEAK-KL-CSTG-------KLRLH-KFI SNSK-NV-IASI-------PQEDLAKGVKDLD-----------------------LDLGE -MYVE-----------------RA--LG-------------------------------- -----VQWSIASDEFQFRVIVK-------------------------------------- ----------------------------------------------------------QP TPPFLLCGMDCFGPFY-------------------------------------------- ----------------------------VT--DG-R-----R-QL-----KR-YGL---L -LTCMC--SRAIHIEMLDALSTDAF-----INALRSF-IAIR-GTVRQIRCDQGTNFVGA SREFM-S-------TLKTMDQG-Q----------------------IK---KL----GCE ----LIMNIPSASHMGGVWERQIRTVRNVLTSVLD--Q---CPGAL----DSTSL----- --RTL-----LYEVMAIVNSRP--------LTV------------E-------------- ----------------------HL--------N----DPLGPEPLTPNHI---------- ----------- >R988/1-548 ---MTKRLILSYIAKIFDPLGLLGPTIIIAKMFMQQ-LWAL-K----------I--HGKA YDWDS-E-LPS--HLQHEWSKFHSTLSSLR---N-LTVP--RYI--S------------- --QC-T-AT--SL-QIHI-FADASQL-AYG-ACCYIR--AES--ME------GVTV-Q-- LLTA---------------------------KSKV-VAL-------S------------- ---NS---------------------------HSIARLELCAAR-LAT-LLYEKVQQS-- -L-K----I-S-----ATT---IC---------WT------------------------- -------------------------------------------------------S-STT TKV-RVVFDASCKTS-SG---YSLNDKLLVGPVVQ--EDLLSIILRFR---SRAI--ALT ADVEKMYRQILHSPH--DRNYLR-----I------RYREH---P-AD---------PI-S TFELQTVTYGTASAPFLATRT-LKQI------------A----LDH-KEEY--P-LAMNA V-MND--FYVDDL-LTGTD-D---LSEAIVIQRQIS-DM-LNSA-------GFTLK-KWA SNRS-EA-LKNVPSEDVAVQL--S-H-EWK---------------------------S-- -SKQV-----------------ST--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------TP TRPFSVCGVDYCGPIY-------------------------------------------- ----------------------------IKQT--IRNR---SPI------KA-YIA---I -FVCFS--TRAVHIELVGDLTSTAF-----INALRRL-IARR-GQISELHSDNATTFKGA AHELN-R-------VYKMLKSD-EHD-----------------RAAIF---DWCAMNHMK ----WKFIPPRAPHFGGLWEAAVKAAKKHIVRTIG--T-----TSI----TQESM----- --LTL-----LAQVEQCLNSRP--------ITP------------L-------------- ----------------------SD--------EPS--D-------L-------------- ----------- >R989/1-558 ----TMRTIYKILASQYDPLGFLTPYLTRAKVLVQQ-LWAK-R----------R------ -DWDD-PDLPL--DLCESWKQWESELPNIS---A-ISIP--RSY--L------------- -PDGMDQ-PNTEH-HLHV-FCDASEK-AYG-AVAYL---SSTQ-GG------ATNV-A-- FVMA---------------------------RSKV-APK--R-Q---------------- --------------------------------QTMPRLELCAAL-AGA-QLANLIQTE-- -L------S-VTL---QRT---TL---------WT------------------------- -----------------------------------ESWYLPHHLV-------YHN----- DKA-RLVFNCSHV-Y-KG---TSLNDQLLPGPNLG--PSLIGVLLRFR---QHQV--AIS GDIRGMFHQVHLLPE--DTPLLR-----F------LW-RD---LQQE---------ASPE IYEWQVLPFGTTSSPCCAIYA-LQRH------------V----REH-PRS---TPGLIES V-ERS--FYVDNC-LESHP-N---GAAAQARVDDLR-SL-LADG-------GFDIR-QWA SNRL-SV-VAHL-------PPEARSKDMELWL-----------------------EHNRS -DQRE-----------------PA--LG-------------------------------- -----LCWNCSSDTLGYRY----------------------------------------- ----------------------------------------------------------IF SPPFHSTGIDCYGPFI-------------------------------------------- ----------------------------AK--IG-R-----R-HE-----KR-WGV---I -FKCLT--TRAVHLDLLNSMDTDAF-----LLALRRF-IARR-GRPVEILSDRGTNFRGA DAELR-A-------AFEEMETQ------------------------LQ---QQLASYQIE ----FKFNPPNAPHFGGVWEREIRSIKNALQVAVG--T---Q--PL----PEDVL----- --HTI-----LVEVEGIINSKP--------LGY------------V-------------- ----------------------SA-------------DI--------------------- ----------- >R992/1-569 ----TRRELLSQVSGVYDPVGLVTPAKQKGAILVRR-AFQEAK----------NTRLQVN ETWDV-A-LSD--DLREDAIKLFEEYIQLG---Q-IKFT--RAI--T------------- -PPEFEGHPWAIT------FSDGSEN-TYG-AVMYLR--WDSK-QG-------PVI-R-- LVES---------------------------KAKL-TPLDQK------------------ --------------------------------GDAIKAEVCGAV-FAS-RLRKYFEQH-- --------SRIQV---ERW---FH---------L-------------------------- ----------------------------------------------------PNPH-SVT TPV-RLVWNSSQR-F-RG---VSMNDLLIKGPDVL--NQIRAVLLRFR---SGVY--AAL GDIKKMYNSVWLEDQ--EVHLHR-----F------LWRDT---E-NE---------ELGE -YAITRVNIGDKPAGCIAQLA-MRET------------A----NLP-SFAH--LEEERRV I-QHD--SYVDDI-LTSHN-D---LDQLQSIVANTE-LI-LKAG-------GFHLK-PWV FSGQ-SG-REK--SDDKCCKIKEKVMVLPNQL--------------------------HD DDNKA-----------------LG--LG-------------------------------- -----YSV---------------------------------------------------- ----------------------------------------------------------QP AAPFEFTAVDLFGPYH-------------------------------------------- ----------------------------VKDDVKKRVLL-----------KV-WGV---V -FCCMS--SRAIHTELVNSQSTEGF-----LLAFQRF-AAIR-GYPRKIFSDPGTNFIGA RPVLQ-D-------LYQFLEGI--------------------DKSTLE---ETAVKHGTE --WIWKIHPADSPHRNGAAEAAVRIIKRALQNCGG--E-----STL----TYSEM----- --HTA-----LQIAANLANERP--------IDA------------R-------------- ----------------------AQTQEGCIQYVTPNSL---------------------- ----------- >R996/1-524 ---PTLRNVYKVLASQYDPIGYLIPFTTRAKVLVQD-LWKT-N----------L------ -TWDD-PITSE--SLLSRWQTWLQELQGLN---H-IAVP--RCY--S------------- -PSDWQA-DKLNR-ELHI-FCDASER-VYG-SVAYMR--TEND-QG------HVHI-S-- FVLA---------------------------RSRV-APR--K-Q---------------- --------------------------------MTIPRLELSAAL-TGA-QVANILQEE-- -L------T-VDI---NRI---IL---------WS------------------------- ---------------A---------------EQSRESWYIPHHMV-------THN----- GKD-RIVFNCSYS-Y-QG---QALNDILLPGPILG--PSLLGVLLRFR---ENPV--AIS GDVKGMFHQVRLLPT--DKSVVR-----F------LW-RD---MQRS---------NQPK IYEWQVLPFGTTCSPCCAIYA-LQMI------------A----QTH-SDG---DPVLEST V-KGS--FYVDNC-LHSLQ-T---VAEARALVDNLR-QL-LLTC-------GFELR-QWA SNKP-EV-IQH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LY KPPFYSTGMDCFGPFT-------------------------------------------- ----------------------------VK--IG-R-----R-RE-----KR-WGI---V -FKCLT--TRCIHLDLVESLDTDAF-----LMALRRF-ISRR-GKPFELLSDNGTNFVGG DKELR-A-------AYESMIPQ------------------------LR---EQLAEQQIT ----FRFIPPGAPHFGGVWEREVKSVKQALKVVLK--D---L--TV----TETVL----- --RTV-----LIEVEGILNAKP--------LGY------------V-------------- ----------------------SS-------------DV--------------------- ----------- >R998/1-561 ----TRRELLSQVSGLYDPVGLVAPVKQKGAILVRR-AFQEAR----------SEQHPAK DTWDK-A-LSA--ELREDAIKLFEECVRLR---D-VKFD--RAL--T------------- -PSNFIGKPWALT------FSDGSEH-SYG-AVMYLR--WETD-ES-------PII-R-- LVEA---------------------------KAKL-SPLDQK------------------ --------------------------------GEAVKAEVCGAV-IAS-RLKKYFQSH-- --------SPIQV---DRW---FH---------FV------------------------- ----------------------------------------------------PNPH-SVT TPV-RLVWNSSQR-F-KG---VSLNDLLLKGPDVL--NQIRAVLLRFR---SGVY--AAI GDVRKMYNSVWLEDR--EVHLHR-----F------LWRNS---A-EE---------EIQE -YAVTRVNIGDKPAGCIAQLA-MRET------------A----SLP-QFSH--LTAEREV L-HRN--AYVDDI-LTSHN-D---LKQLQATTKGVE-DI-LKAG-------GFALK-PWV FSGQ-SG-RGD--HIDRQETVQKDAFVLPNQM--------------------------SD DDNKA-----------------LG--LG-------------------------------- -----YIV---------------------------------------------------- ----------------------------------------------------------RP AAPFQFTTVDLFGPYL-------------------------------------------- ----------------------------VKDDVKRRVTL-----------KT-WGV---V -FSCMA--CRAIHLDLVNSVSSESF-----LMAYQRF-TAIR-GHPSKLWSDPGTNFIGA KPVLQ-D-------LYQFLESQ--------------------NKAALA---EYAVSRGTE --WRWQIHPADSPHRNGAAEAAVRVAKRALQALDK--N-----TML----SYSEF----- --QTV-----LFTAANLANERP--------IEA------------R-------------- ----------------------VQSKEDC------------------------------- ----------- >Sin266/1-532 ----TRRSMLSEVSSIYDPLGFIAPLLIPAKSVLQE-MCKQ-E----------A------ -GWDD-E-PSD--NIHGKWQMWKTSMQDLE---E-VRIS--RCY--V------------- -PAEFGN--VTYR-ELHA-FADASEI-GYG-CVIYLR--QINS-SE------NIHC-S-- FVFA---------------------------KARV-TPL--K-K---------------- --------------------------------ITIPRLELTAAT-LAV-RLVSIVQRE-- -L------D-FKI---DKA---IY---------WT------------------------- ---------------T---------------AKKGKEWYIPHHGV-------YHPR-K-P NKI-RVVFDCAAK-C-DG---TSLNDVLLPGPNLM--NDLKGVLMRFR---EFPV--AFA SDIECMFYQVKVPES--QRDLLR-----F------LWLPK---GDLD---------QKPK VYRMAVHLFGAVSAPSCANYS-LRRT------------G----IDN-ICNA--REETVNT L-HNN--FYMDDG-LKSVE-N---VEQAIQLVKELK-AL-CKEG-------GFNLT-KWS SNER-EV-LRE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE VSPFTFCGMDYFAPLT-------------------------------------------- ----------------------------VR--RG-R-----S-EV-----KR-YGV---I -FTCFS--SRAVHLEIAHSLETDAC-----INAIRRF-MARR-GPVRSIRSDNGTNLVGS EKELR-H-------ALEGLDQS-R----------------------MN---DVLCAEGIE ----WHFNPPAASHFGGVWERMIRSIRKILYSLLR--E---QPRIV----DDETL----- --STL-----FCEAENIVNNRP--------LTT------------T-------------- ----------------------SS-------------D--------PNDL---------- ----------- >Suz254/1-538 -------------------------------------HFKRPN----------PNVAPAK -TLGI-L-RSE--KLREDAISLFEEYAQLS---K-VKFH--RAL--T------------- -PAGAPAEPDAIT------FSDGSEH-AYG-AVLYLR--WACN-QG-------SMV-R-- LVES---------------------------KAKL-TPLDHK------------------ --------------------------------GEAVKSELCGAV-FAA-WLKKYFEQH-- --------GRIQV---KQW---YH---------FV------------------------- ---------------R---------------EWTGPVWYISHLIA-------PNPH-SVT TPV-RLVWNSSQK-C-RG---VSLNDLLLKGPDVL--NSIRAVLLKFR---RGGF--AAL GDVKKMYNSVWLEDQ--EVHLHR-----F------LWRDS---E-EE---------ELAE -YAVTRVNIGDKPAGCIAQLA-MRET------------A----NLP-QFSH--LEEERRV L-QED--SYVDDL-LTSHD-N---LDQLKVITGNVE-QI-LKAG-------GFELK-PWV FTGQ-SR-RESSGNDQ---AVTPRTVILPNQL--------------------------KE EDNKA-----------------LG--LG-------------------------------- -----YTL---------------------------------------------------- ----------------------------------------------------------RP AAPFEFTAVDLFGPYL-------------------------------------------- ----------------------------VKDDVKKRVRM-----------KV-WAV---V -FCCMA--SRAIHTELANTMSTESF-----LMAYQRF-TAIR-GHPKKIWSDPGTNFVGA KPVLE-E-------LYQFLDGL--------------------DRPAVE---ETSAQNGTS --WHWEIQPADSPHRNGSAEAAVRIVEKAFQSLGR--E-----SEL----SYSEL----- --QTT-----LQLTANLSNERP--------IDA------------R-------------- ----------------------VQS----------------------------------- ----------- >Suz261/1-579 ----TKRKILGKVARIYDPIGFAAPIIIKAKTGLQK-LWQS-G----------Y------ -DWDE-E-L-P--DGD-EWRGLFREMSKLN---D-ISLE--RCL--K------------- -PQNAQG----RP-VLCI-FCDASEI-AYG-ACAYLR--WKTD-DD------KYEV-R-- FVSA---------------------------KSKV-APL--K-A---------------- --------------------------------LTIPRLELLAGV-LAA-RMHEAISNE-- -M------R-LQV---EKV---VF---------FT------------------------- ---------------------------------------ISHHAV-------IRPD-NKS TPL-RIVFNSSAI-Y-KG---HCLNEYWKKGPDLL--NNLFGVLLRFR---EHPV--AIC ADISKMYHRILIPER--DQHVHR-----F------LWRDM---N-QE---------KEPD VYMMKVVTFGDKPAAAMAQIG-VRLT------------A----EEG-EAKY--PEAA-AI L-KRN--IYMDDI-CDSVE-T---EDTAKKRIAEVD-EL-LEAG-------GFKVK-GWQ SNKP-LD-GGNKQEKMKLLEEIAEEKVLGVVWERHNDTFSYKVKLQE------TDKET-E KLTKR-----------------KI--LG-------------------------------- -----KVA---------------------------------------------------- ----------------------------------------------------------PF TPPFHYTSCDYFGPYL-------------------------------------------- ----------------------------VK--VG-R-----NKKA-----KH-YGI---I -FTCLN--TRAVHLEMATDCSTMEF-----LQALRRF-IAVR-GQPAQFLSDNGTQFVGA ERELR-E-------MVRGWSER-E----------------------LK---DFCAEKRVV ----WKFVTPGAPHQNGCAEAMVKSCKFALKRAIG--E-----QVL----TPLEL----- --YTC-----FLEVANLVNERP--------IGR------------V-------------- ----------------------GN-------------DPDDGGYLCPNDL---------- ----------- >Suz265/1-561 ----TRRELLSQVSGLYDPVGLVAPVKQKGAILVRR-AFQEAR----------SEQHPAK DTWDK-A-LSA--ELREDAIKLFEECVRLR---D-VKFD--RAL--T------------- -PSNFIGKPWALT------FSDGSEH-SYG-AVMYLR--WETD-ES-------PII-R-- LVEA---------------------------KAKL-SPLDQK------------------ --------------------------------GEAVKAEVCGAV-IAS-RLKKYFQSH-- --------SPIQV---DRW---FH---------FV------------------------- ----------------------------------------------------PNPH-SVT TPV-RLVWNSSQR-F-KG---VSLNDLLLKGPDVL--NQIRAVLLRFR---SGVY--AAI GDVRKMYNSVWLEDR--EVHLHR-----F------LWRNS---A-EE---------EIQE -YAVTRVNIGDKPAGCIAQLA-MRET------------A----SLP-QFSH--LTAEREV L-HRN--AYVDDI-LTSHN-D---LKQLQATTKGVE-DI-LKAG-------GFALK-PWV FSGQ-SG-RGD--HIDRQETVQKDAFVLPNQM--------------------------SD DDNKA-----------------LG--LG-------------------------------- -----YIV---------------------------------------------------- ----------------------------------------------------------RP AAPFQFTTVDLFGPYL-------------------------------------------- ----------------------------VKDDVKRRVTL-----------KT-WGV---V -FSCMA--CRAIHLDLVNSVSSESF-----LMAYQRF-TAIR-GHPSKLWSDPGTNFIGA KPVLQ-D-------LYQFLESQ--------------------NKAALA---EYAVSRGTE --WRWQIHPADSPHRNGAAEAAVRVAKRALQALDK--N-----TML----SYSEF----- --QTV-----LFTAANLANERP--------IEA------------R-------------- ----------------------VQSKEDC------------------------------- ----------- >Tas263/1-547 ---PTKRQVASKMAETFDPLGLITPLIVSFKRLMQN-LW-RNP----------M------ -KWND-P-IPK--ELLADWKAIQAAFMDTK-----ITVP--RRI---------------- ---SISDDPPEEI-QLIM-FSDASTD-IYA-TAVYVQ--YSY-KSR------KPVT-R-- LLTS---------------------------KSKI-RSAKNE-M---------------- --------------------------------WTIPKLELLGIE-CSS-NLARTIIAELG TL------A---TKI-KKV---RL---------FT------------------------- ------------------------------------KYYTPHRAV-------IKE-TSNT TKL-RIVLDASSPPG-PE---PSLNDCLYAGDNLV--TPLYGILLRGR---IYPY--VVV ADIEKAFHQVRLPTE--FRNASL-----F------LWLKD---I-TK----PPTPDNI-C TYRFTRIPFGVASSPWLLAAS-ILHF------------L-------DRNPN--P-LN-QR V-REN--LYVDNC-LIGTF-D---KSEITEIIKNSK-DI-FMKM-------KMNLR-EYV TNSE-EH-MVAIEVEDQ--A---------------------------------------- KHRVI-----------------KL------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EP SKPFAKVGLDYLGPVE-------------------------------------------- ----------------------------YLRDDQESIG------------KA-YVL---L -YTCLV--TRAAVLRVVPDATTESY-----LMALRTI-FHQV-GVPSEVHSDNAAIFKLG AKMTN-D-------DIRE----------GSEI-----------DEIFT---CFLASQEIK ----FIYITPWSPWQGGVYERIIGLLKHQIHKICG--D-----QKL----DFFSL----- --QYV-----VSSAQAMINNRP--------LVA------------H-------------- ----------------------AR--------SPN--D-------M-------------- ----------- >Tas264/1-558 ----TKRQLISVTAKVYDPLGHLSPYLIKAKVLFQK-LWKK-G----------L------ -NWDD-E-LPS--DLQKEWQIWKMELSDIS---D-IRIP--RCL--I------------- -PFHGST--IKKI-ELHA-FGDASET-AYG-AVVYIV--VKKE-DY------SSIS-N-- IVMA---------------------------KSRV-APL--K-K---------------- --------------------------------MTLPRLELMAAQ-MAA-KLMTFVKEA-- -L------K-IRI---DRL---TC---------WT------------------------- ------------------------------QGRPGRTWYLPHHTV-------LRE-DKSS TKC-RIVFDGSAQFR-ND----SLNRQLDPGPPLQ--KDLVQILLRFR---RFRV--GLQ ADISKMFLQIGLHEK--DRDVTR-----F------LWREL---G-SQ--------ETP-R IFRFKRVCFGLTCSPFLAMSV-TRHH------------A----LNHLQGFP--Q-AA-NQ V-LEN--MYVDDI-VFSVD-E---DDVARETVRQLV-SL-MKKG-------GFHLT-KWV SNLS-TV-LADVPSEDIMGKN--------------------------------------- TNT-S-----------------KI--LG-------------------------------- -----IVW---------------------------------------------------- ----------------------------------------------------------RV TRPFENTGLDIAGPFF-------------------------------------------- ----------------------------TRQ-GKK-------VN------KN-YIC---L -FTCMS--TRAVHLEVVSEMTAPRL-----LQALRRF-IARR-GRPHILQSDNFKSFKQL DKDLS-Q-------LVSTEM-----------------------IDNVA---RELTSHRIQ ----WNFITERAPWMGGYWERLIRSMKTSLKKVLQ--N-----SML----EDEEF----- --RTI-----ISEVEARMNSRP--------LTY------------N-------------- ----------------------PD--------NPN--N-------PEVLTPYHF------ ----------- >Tas267/1-523 ----TKRIILQFVASQYDPLGFIVPILIRFKLFLQT-LWK-KN----------L------ -SWDQ-T-ISE--EDETTWKLLTNEWPK-K---L-KDLP--RFT--T------------- ----N---CSKQV-QFHV-FTDASTA-AYS-AALYIR--TQ---E--------REV-F-- LVFA---------------------------KSRI-API--K-------G---------- --------------------------------MSIPRLELLAIL-IGV-RMVQFVLKQ-- -K------E-LEDV---IT---IL---------WS------------------------- -------------------------------------HYLPHHEV-------ITP-NKTT TNL-RIVYDASAHCK-GM---KSLNDVLYRGPITL--PDLVGVLLRFR---TMKN--VII ADVEKAFLQIELHPT--DRNCTR-----F------LWLKD---I-RS----PVNEENV-S CYRFQRVPFGIVSSPFLLSAT-LNYH------------L------ETCKS---K-IA-LE L-RKN--LYVDNI-IIPTK-G---TNEALSNYKEIK-II-FNEA-------SMNVR-EFL SNDQ-EV-NEKLPVQDR--AE--------------------------------------- VSSIK-----------------KI--LG-------------------------------- -----LNW---------------------------------------------------- ----------------------------------------------------------TR SRPFARVGLDYLGPVN-------------------------------------------- ----------------------------IRS--DNGLT------------KR-WVA---L -FTCFT--TRAVHLEVVETLSAESF-----LHVFRRF-TARR-GFPELILSDNAGQFQLI FKIIV-K--------------Q------QL-----------------N---EFLAERKMI ----WKNIIPKAPWNGGVYERLIGLTKRAMKRAIG--R-----KLL----WEREL----- --ITL-----VAEVESILNTRP--------LTY------------V-------------- ----------------------NF------------------------------------ ----------- >Tas270/1-534 ---MTKRQLLSYIAAQYDPTGHIPPLFTPLKVILQD-LLR-KN----------Q------ -KWDE-R-LPE--NITKQIDSICGEWNDRT-----IEVP--RFV--I------------- -------KRQAAL-QLHC-FTDASKT-AYA-SAIYIR--T--EMNS------EIEC-H-- LLIC---------------------------KTRL-EPL--K----GS------------ ---------------------------------TIPHLELMGAL-IGT-RLLEYTSQQ-- -L------Q-LESAD-K-----YI---------WT------------------------- --------------------------------------------------------HKTT TKI--VVFDGSSKSR-GT---KSINEAIMRGPVLL--PNLGGLLLRFR---SMPI--AII GDLEKAFLQVALNKP--DRDAAR-----F------LWLSD---I-NS----SPSHSNL-- VFRFARVPFGLNASPFLPTAT-IKTH------------L------DSYGDV--A-LA-EE I-WKN--IYVDNV-LISAR-T---TKEAFNKFESIK-KL-FEDA-------RMNIR-EFL SNDA-TF-NKTIPERDR--H---------------------------------------- EATNA-----------------KL--LG-------------------------------- -----LRW---------------------------------------------------- ----------------------------------------------------------SK HPPFENTGVDYIGPFT-------------------------------------------- ----------------------------IRSMKRITQN---------------DGS---V -YSLVS------QLELYISKSPLTYPDQVSFSVYVRF-VSRR-GLPKRMLSDNGTQFVWA RSVLT-S-------VSKVHQT----------------------DNAIL---DYCAAHNIQ ----WSFITPLVPWQGGIYERMVGPVKGSMKKTIG--W-----KRL----TQEEL----- --QTL-----TTDIEAVVNCRP--------IIP------------L-------------- ----------------------TS--------ENT-----------TVLRPVDF------ ----------- >Tas272/1-548 ---PTKREVMSFIASIYDPIGLINPVVVTCKNLFQR-ICVS-K----------L------ -GWNE-N-LYG--DLLSTWNLILSDFKSVF---Q-IAVP--RWYMSP------------- -GLGNINN--VKF-ELHG-FSDASVK-SFG-CCVYLR---FFNANF------S-RA-S-- LIAS---------------------------KSRV-APL--G-K---------------- --------------------------------NTMPRLELSATL-LLA-KLLASIYDQ-- -L------I-SIYNI-SNI---VY---------WT------------------------- --------------------------------------YLPHRPV-------CRK-DKTS TKV-RIVFDASST---LS--GPSLNDCINAGPSLA--TPLFFILLRFR---ANKY--AFI ADIEKAFLQIALDKN--DRNYLR-----L------IWFDD---I-YNINNSNLFSSAL-A TYRICRVPFGVTSSPFLLNAT-LIYH------------A----ERYCLNDN--N-IS-SK L-LQS--LHIDDL-ISSCV-T---IEEGILFFNKCK-DI-LKEG-------GFNLR-KFE SNSS-AF-EKQINGDNYERQ---------------------------------------- -TNT------------------RV--LG-------------------------------- -----LKW---------------------------------------------------- ----------------------------------------------------------NS DFAFKSIALDYAGPLY-------------------------------------------- ----------------------------IKDIYGD--C---TLN------KA-WIF---L -FTCCS--SRSILLDLVADCSSSSC-----IMGIRRF-IGRR-GVPEIIYSDNGSQFVS- --------------------------------------------TETQ---YFAANHSIK ----WKFNAPSAPWWGGMFERLVRMTKRCLKKALK--N-----SKS----SYEEV----- --RTL-----LSEIDMVLNNRP--------LTY------------L-------------- ----------------------YN--------NQG--D-------EA-LTPNHL------ ----------- >copia/1-548 GESKEKSNCLMHISATTQ----------------RKNIWCV------------------- ---DSGA-TSHMCCDKGLFTSFINKETSIM-----LAAD--KFV---------------- -----KSSGIGTV-MLKSQNVNIELR-----DVIYVP---------------SLHM-N-- FLSV----------------------------SKS-AEY--------------------- --------------------------------ENITTFDKKAAV-IKN-KQGEVMMRA-- -M------Q------------------------ED------------------------- --------------------SMQKEYDALVSNNTWTLCDLPPGQKAIGSKWVFRVKRDKE GNIQKFKSRLVAQGCGQK---MGVNYSETFSPVIR--YETIRMLFAIA---AEKQLCMHQ VDISNAYLNGRLQEEVYMRQPQN-----F--------------IDEK---------HPNK VLKLQKAIYGLKQSGRVWNDT-LDEVLKSIGFKRSKNEACLYAKQQ-QQQH--SYIA--- -------VYVDDLIIISYD-----ENEISAIKRKIANKFDIHDGGQLNYFLGMEIQ-RES TRGSISLCQKQFIINLLDKYGMQNCRPAATPLD--------------------------- --------------------------PG-------------------------------- ------------------------------------------------------------ ----------------------------------------------------------AT QSVLELVHSDVCGPMN-------------------------------------------- ----------------------------VSSLGGNK-----------------YFV---T -FIDDY--SRKIFIYFMHA-KNEVFDK---FKLFKSYVECQTGKKIKALRSDNGTEYV-- NRQFT----------------------------------------------EYLNTCGIK ----RQLTVPYTPQQNGVAERANRTIVEMAKSMLI--H-----AKLEEFLWAEAV----- --STASYLRNRCPSKALMGATP--------FEI--------------------------- ------------------------------------------------------------ -----------