{"text_format":"3","workbook":"xls","n_sheets":10,"sheets":["Table S1 number of individuals","Table S2 list of genes","Table S3 mean Fst by gene","Table S4 Fst combined p-values","Table S5 mean iHS by gene","Table S6 iHS combined p-values","Table S7 Mann-Whitney U test","Table S8 Chi-test comparison","Table S9 hypergeometric test","Table S10 centralities"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table S1 number of individuals","index":0,"n_rows":67,"n_cols":3,"rows_kept":67,"flags":["formulas_cached_only"]}
["Table S1a: Number of individuals by Continental Group. Continental Groups are defined in the Methods section. "]
[]
["Continental Group","Continental Group Code","Number of Individuals"]
["Sub-Saharan Africa","SSAFR",101]
["Middle-East-North Africa","MENA",163]
["Europe","EUR",157]
["Central-South Asia","CSASIA",200]
["East Asia","EASIA",228]
["Oceania","OCE",27]
["America","AME",64]
[]
["Table S1b: number of individuals by Population"]
[]
["Continental Group","Population","Number of Individuals"]
["SSAFR","Mbuti-pygmy",13]
["SSAFR","Biaka-pygmy",21]
["SSAFR","San",5]
["SSAFR","Bantu (Kenya)",11]
["SSAFR","Mandenka",22]
["SSAFR","Yoruba",21]
["SSAFR","Bantu (South Africa)",8]
["MENA","Bedouin",46]
["MENA","Palestinian",46]
["MENA","Druze",42]
["MENA","Mozabite",29]
["EUR","Orcadian",15]
["EUR","Adygei",17]
["EUR","Italian",12]
["EUR","Tuscan",8]
["EUR","Sardinian",28]
["EUR","Russian",25]
["EUR","Basque",24]
["EUR","French",28]
["CSASIA","Balochi",24]
["CSASIA","Sindhi",24]
["CSASIA","Hazara",22]
["CSASIA","Uygur",10]
["CSASIA","Brahui",25]
["CSASIA","Kalash",23]
["CSASIA","Pathan",22]
["CSASIA","Burusho",25]
["CSASIA","Makrani",25]
["EASIA","Oroqen",9]
["EASIA","Tujia",10]
["EASIA","Han-nchina",10]
["EASIA","Dai",10]
["EASIA","Hezhen",8]
["EASIA","Naxi",8]
["EASIA","Cambodian",10]
["EASIA","Tu",10]
["EASIA","Yi",10]
["EASIA","Japanese",28]
["EASIA","Lahu",8]
["EASIA","Mongola",10]
["EASIA","She",10]
["EASIA","Han",34]
["EASIA","Xibo",9]
["EASIA","Yakut",25]
["EASIA","Daur",9]
["EASIA","Miao",10]
["OCE","Papuan",17]
["OCE","Melanesian",10]
["AME","Colombian",7]
["AME","Pima",14]
["AME","Karitiana",14]
["AME","Surui",8]
["AME","Maya",21]

{"sheet":"Table S2 list of genes","index":1,"n_rows":70,"n_cols":9,"rows_kept":70,"flags":["formulas_cached_only"]}
["Table S2: List of genes analyzed"]
[]
["Gene name","Ensembl ID","Position Upstream/Downstream of\nER Quality Control Cycle","Sub-pathway","chromosome","start","end","SNPs within ± 100 kb ","notes"]
["ALG1","ENSG00000033011","Upstream","Precursor biosynthesis",16,5061810,5077379,51]
["ALG10","ENSG00000139133","Upstream","Precursor biosynthesis",12,34066482,34072503,22,"a"]
["ALG10B","ENSG00000175548","Upstream","Precursor biosynthesis",12,36996823,37009795,25,"a"]
["ALG11","ENSG00000253710","Upstream","Precursor biosynthesis",13,51484550,51501781,29]
["ALG12","ENSG00000182858","Upstream","Precursor biosynthesis",22,48682856,48698110,22]
["ALG13","ENSG00000101901","Upstream","Precursor biosynthesis","X",110811069,110818680,"NA","a"]
["ALG14","ENSG00000172339","Upstream","Precursor biosynthesis",1,95220866,95311095,72]
["ALG2","ENSG00000119523","Upstream","Precursor biosynthesis",9,101018527,101024067,48]
["ALG3","ENSG00000214160","Upstream","Precursor biosynthesis",3,185442810,185449453,41]
["ALG6","ENSG00000088035","Upstream","Precursor biosynthesis",1,63605848,63676820,46]
["ALG8","ENSG00000159063","Upstream","Precursor biosynthesis",11,77489635,77528347,56]
["ALG9","ENSG00000086848","Upstream","Precursor biosynthesis",11,111158128,111247214,26]
["DPAGT1","ENSG00000172269","Upstream","Precursor biosynthesis",11,118472422,118477995,37]
["RFT1","ENSG00000163933","Upstream","Precursor biosynthesis",3,53097542,53139510,53]
["DAD1","ENSG00000129562","Upstream","OST complex",14,22103646,22127983,115]
["DDOST","ENSG00000244038","Upstream","OST complex",1,20850846,20860624,58]
["RPN1","ENSG00000163902","Upstream","OST complex",3,129821502,129852409,31]
["RPN2","ENSG00000118705","Upstream","OST complex",20,35240869,35303437,34]
["STT3A","ENSG00000134910","Upstream","OST complex",11,124967948,124996490,36]
["STT3B","ENSG00000163527","Upstream","OST complex",3,31549494,31652560,74]
["TUSC3","ENSG00000104723","Upstream","OST complex",8,15442100,15666366,257]
["EDEM3","ENSG00000116406","Upstream","CNX CRT",1,182926247,182990664,44]
["GANAB","ENSG00000089597","Upstream","CNX CRT",11,62148873,62170680,17]
["GCS1","ENSG00000115275","Upstream","CNX CRT",2,74541691,74546045,16]
["MAN1B1","ENSG00000177239","Upstream","CNX CRT",9,139101237,139123460,18]
["PRKCSH","ENSG00000130175","Upstream","CNX CRT",19,11407268,11422782,23]
["UGCGL1","ENSG00000136731","Upstream","CNX CRT",2,128565363,128665461,42]
["UGCGL2","ENSG00000102595","Upstream","CNX CRT",13,95251836,95503638,41]
["FUT8","ENSG00000033170","Downstream","Branching 1",14,64947592,65279715,101]
["MAN1A1","ENSG00000111885","Downstream","Branching 1",6,119540965,119712625,98]
["MAN1A2","ENSG00000198162","Downstream","Branching 1",1,117711607,117869843,81]
["MAN1C1","ENSG00000117643","Downstream","Branching 1",1,25816545,25983845,43]
["MAN2A1","ENSG00000112893","Downstream","Branching 1",5,109053054,109231328,100]
["MAN2A2","ENSG00000196547","Downstream","Branching 1",15,89248423,89266819,56]
["MGAT1","ENSG00000131446","Downstream","Branching 1",5,180150146,180162654,41]
["MGAT2","ENSG00000168282","Downstream","Branching 1",14,49157238,49159949,26]
["MGAT3","ENSG00000128268","Downstream","Branching 1",22,38213174,38218145,39]
["MGAT5","ENSG00000152127","Downstream","Branching 1",2,134728299,134922938,151]
["B4GALT1","ENSG00000086062","Downstream","Branching 2",9,33100638,33157356,83]
["B4GALT2","ENSG00000117411","Downstream","Branching 2",1,44217452,44229427,48]
["B4GALT3","ENSG00000158850","Downstream","Branching 2",1,159407724,159413938,45]
["MGAT4A","ENSG00000071073","Downstream","Branching 2",2,98602000,98714021,49]
["MGAT4B","ENSG00000161013","Downstream","Branching 2",5,179156710,179162677,28]
["MGAT5B","ENSG00000167889","Downstream","Branching 2",17,72376392,72458066,118]
["ST3GAL4","ENSG00000110080","Downstream","Branching 2",11,125731305,125789743,86]
["ST6GAL1","ENSG00000073849","Downstream","Branching 2",3,188131209,188279035,120]
["ST8SIA2","ENSG00000140557","Downstream","Branching 2",15,90738143,90812962,139]
["ST8SIA3","ENSG00000177511","Downstream","Branching 2",18,53170718,53187159,44]
["ST8SIA6","ENSG00000148488","Downstream","Branching 2",10,17402681,17536260,120]
["ALG5","ENSG00000120697",null,"substrates",13,36421909,36471504,44]
["DOLK","ENSG00000175283",null,"substrates",9,130747629,130749833,21]
["DOLPP1","ENSG00000167130",null,"substrates",9,130883203,130892537,32]
["DPM1","ENSG00000000419",null,"substrates",20,48984811,49008467,63]
["DPM2","ENSG00000136908",null,"substrates",9,129737202,129739956,39]
["DPM3","ENSG00000179085",null,"substrates",1,153378990,153379507,28]
["GMPPA","ENSG00000144591",null,"substrates",2,220071856,220079955,31]
["GMPPB","ENSG00000173540",null,"substrates",3,49733935,49736388,10,"a"]
["PGM3","ENSG00000013375",null,"substrates",6,83935346,83959654,36]
["PMM1","ENSG00000100417",null,"substrates",22,40302835,40315817,24]
["PMM2","ENSG00000140650",null,"substrates",16,8799170,8850695,82]
["UAP1","ENSG00000117143",null,"substrates",1,160797919,160836257,52]
["MANEA","ENSG00000172469",null,null,6,96132133,96164047,46,"b"]
[]
[]
["a: Genes not included in the analysis given their low number of SNPs, or because they are in the X chromosome."]
["b: MANEA gene is relevant to the pathway, but can not be classified in a subpathway"]
["Note that genes involved in the synthesis of substrates are not included in Upstream/Downstream distintion as the product of these genes is required both in the upstream and the downstream part of the Asparagine N-Glycosylation pathway"]

{"sheet":"Table S3 mean Fst by gene","index":2,"n_rows":62,"n_cols":29,"rows_kept":62,"merged":[[2,1,2,4],[2,5,2,8],[2,9,2,12],[2,13,2,16],[2,17,2,20],[2,21,2,24],[2,25,2,27],[3,2,3,3],[3,6,3,7],[3,10,3,11],[3,14,3,15],[3,18,3,19],[3,22,3,23],[3,26,3,27]],"flags":["formulas_cached_only"]}
["Table S3: Mean FST values per Gene, by Continental group. The mean FST value is indicated for each gene region (gene ± 100 kb) along with lower and upper 95% confidence interval and the number of SNPs used."]
[]
[null,"SSAFR",{"$nulls":3},"MENA",{"$nulls":3},"EUR",{"$nulls":3},"CSASIA",{"$nulls":3},"EASIA",{"$nulls":3},"OCE",{"$nulls":3},"AME"]
["gene","mean","95% CI",null,"N","mean","95% CI",null,"N","mean","95% CI",null,"N","mean","95% CI",null,"N","mean","95% CI",null,"N","mean","95% CI",null,"N","mean","95% CI",null,"N"]
["ALG1",{"v":0.047,"d":"0.05"},{"v":0.033,"d":"0.03"},{"v":0.061,"d":"0.06"},35,{"v":0.026000000000000002,"d":"0.03"},{"v":0.015,"d":"0.02"},{"v":0.037,"d":"0.04"},37,{"v":0.007,"d":"0.01"},{"v":0.004,"d":"0.00"},{"v":0.011,"d":"0.01"},36,{"v":0.023,"d":"0.02"},{"v":0.017,"d":"0.02"},{"v":0.028,"d":"0.03"},36,{"v":0.007,"d":"0.01"},{"v":0.005,"d":"0.01"},0.01,32,{"v":0.14200000000000002,"d":"0.14"},{"v":0.093,"d":"0.09"},{"v":0.192,"d":"0.19"},27,{"v":0.065,"d":"0.07"},{"v":0.041,"d":"0.04"},{"v":0.088,"d":"0.09"},31]
["ALG11",{"v":0.031,"d":"0.03"},0.02,{"v":0.042,"d":"0.04"},23,{"v":0.021,"d":"0.02"},{"v":0.013000000000000001,"d":"0.01"},{"v":0.029,"d":"0.03"},24,{"v":0.017,"d":"0.02"},{"v":0.013000000000000001,"d":"0.01"},{"v":0.021,"d":"0.02"},24,{"v":0.008,"d":"0.01"},{"v":0.005,"d":"0.01"},{"v":0.012,"d":"0.01"},24,{"v":0.021,"d":"0.02"},{"v":0.012,"d":"0.01"},0.03,22,{"v":0.227,"d":"0.23"},{"v":0.178,"d":"0.18"},{"v":0.276,"d":"0.28"},22,{"v":0.11800000000000001,"d":"0.12"},{"v":0.084,"d":"0.08"},{"v":0.153,"d":"0.15"},23]
["ALG12",{"v":0.068,"d":"0.07"},{"v":0.025,"d":"0.03"},{"v":0.111,"d":"0.11"},18,{"v":0.015,"d":"0.02"},0.01,{"v":0.021,"d":"0.02"},17,{"v":0.007,"d":"0.01"},{"v":0.001,"d":"0.00"},{"v":0.013000000000000001,"d":"0.01"},17,{"v":0.042,"d":"0.04"},{"v":0.027,"d":"0.03"},{"v":0.057,"d":"0.06"},17,{"v":0.005,"d":"0.01"},{"v":0.002,"d":"0.00"},{"v":0.008,"d":"0.01"},15,{"v":0.052000000000000005,"d":"0.05"},{"v":0,"d":"0.00"},{"v":0.126,"d":"0.13"},12,{"v":0.048,"d":"0.05"},{"v":0.002,"d":"0.00"},{"v":0.094,"d":"0.09"},15]
["ALG14",{"v":0.032,"d":"0.03"},0.02,{"v":0.044,"d":"0.04"},37,{"v":0.025,"d":"0.03"},{"v":0.013000000000000001,"d":"0.01"},{"v":0.037,"d":"0.04"},40,{"v":0.025,"d":"0.03"},{"v":0.018000000000000002,"d":"0.02"},{"v":0.032,"d":"0.03"},40,{"v":0.019,"d":"0.02"},{"v":0.011,"d":"0.01"},{"v":0.027,"d":"0.03"},40,0.01,{"v":0.005,"d":"0.01"},{"v":0.015,"d":"0.02"},37,{"v":0.114,"d":"0.11"},{"v":0.077,"d":"0.08"},{"v":0.151,"d":"0.15"},29,{"v":0.138,"d":"0.14"},{"v":0.093,"d":"0.09"},{"v":0.182,"d":"0.18"},27]
["ALG2",{"v":0.055,"d":"0.06"},{"v":0.037,"d":"0.04"},{"v":0.074,"d":"0.07"},39,{"v":0.015,"d":"0.02"},0.01,0.02,36,{"v":0.009000000000000001,"d":"0.01"},{"v":0.006,"d":"0.01"},{"v":0.012,"d":"0.01"},35,{"v":0.026000000000000002,"d":"0.03"},{"v":0.018000000000000002,"d":"0.02"},{"v":0.033,"d":"0.03"},31,{"v":0.015,"d":"0.02"},0.01,{"v":0.019,"d":"0.02"},26,{"v":0.146,"d":"0.15"},{"v":0.084,"d":"0.08"},{"v":0.20800000000000002,"d":"0.21"},13,{"v":0.098,"d":"0.10"},{"v":0.07100000000000001,"d":"0.07"},{"v":0.126,"d":"0.13"},32]
["ALG3",{"v":0.033,"d":"0.03"},{"v":0.021,"d":"0.02"},{"v":0.045,"d":"0.05"},25,{"v":0.011,"d":"0.01"},{"v":0.006,"d":"0.01"},{"v":0.016,"d":"0.02"},32,{"v":0.013000000000000001,"d":"0.01"},{"v":0.008,"d":"0.01"},{"v":0.017,"d":"0.02"},34,{"v":0.027,"d":"0.03"},{"v":0.018000000000000002,"d":"0.02"},{"v":0.036000000000000004,"d":"0.04"},33,0.03,0.02,0.04,26,{"v":0.023,"d":"0.02"},{"v":0,"d":"0.00"},{"v":0.049,"d":"0.05"},13,{"v":0.1,"d":"0.10"},{"v":0.054,"d":"0.05"},{"v":0.146,"d":"0.15"},23]
["ALG5",{"v":0.056,"d":"0.06"},{"v":0.034,"d":"0.03"},{"v":0.079,"d":"0.08"},24,{"v":0.026000000000000002,"d":"0.03"},{"v":0.011,"d":"0.01"},0.04,21,{"v":0.011,"d":"0.01"},{"v":0.006,"d":"0.01"},{"v":0.017,"d":"0.02"},22,{"v":0.019,"d":"0.02"},0.01,{"v":0.028,"d":"0.03"},20,{"v":0.026000000000000002,"d":"0.03"},{"v":0.015,"d":"0.02"},{"v":0.037,"d":"0.04"},16,{"v":0.167,"d":"0.17"},{"v":0.049,"d":"0.05"},{"v":0.28500000000000003,"d":"0.29"},10,{"v":0.046,"d":"0.05"},0.02,{"v":0.07200000000000001,"d":"0.07"},20]
["ALG6",{"v":0.028,"d":"0.03"},{"v":0.015,"d":"0.02"},{"v":0.042,"d":"0.04"},25,{"v":0.001,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0.002,"d":"0.00"},28,{"v":0.009000000000000001,"d":"0.01"},{"v":0.003,"d":"0.00"},{"v":0.014,"d":"0.01"},29,{"v":0.031,"d":"0.03"},{"v":0.021,"d":"0.02"},0.04,31,{"v":0.028,"d":"0.03"},0.02,{"v":0.037,"d":"0.04"},29,{"v":0.08700000000000001,"d":"0.09"},{"v":0.021,"d":"0.02"},{"v":0.153,"d":"0.15"},18,{"v":0.11800000000000001,"d":"0.12"},{"v":0.08600000000000001,"d":"0.09"},{"v":0.151,"d":"0.15"},27]
["ALG8",0.07,{"v":0.051000000000000004,"d":"0.05"},0.09,39,{"v":0.019,"d":"0.02"},{"v":0.013000000000000001,"d":"0.01"},{"v":0.026000000000000002,"d":"0.03"},42,{"v":0.019,"d":"0.02"},{"v":0.012,"d":"0.01"},{"v":0.026000000000000002,"d":"0.03"},43,{"v":0.027,"d":"0.03"},{"v":0.021,"d":"0.02"},{"v":0.033,"d":"0.03"},44,{"v":0.028,"d":"0.03"},0.02,{"v":0.037,"d":"0.04"},37,{"v":0.105,"d":"0.11"},{"v":0.083,"d":"0.08"},{"v":0.127,"d":"0.13"},28,{"v":0.055,"d":"0.06"},{"v":0.035,"d":"0.04"},{"v":0.074,"d":"0.07"},32]
["ALG9",0.05,{"v":0.016,"d":"0.02"},{"v":0.083,"d":"0.08"},12,{"v":0.009000000000000001,"d":"0.01"},{"v":0.001,"d":"0.00"},{"v":0.017,"d":"0.02"},12,{"v":0.007,"d":"0.01"},{"v":0.001,"d":"0.00"},{"v":0.014,"d":"0.01"},13,{"v":0.029,"d":"0.03"},{"v":0.016,"d":"0.02"},{"v":0.043000000000000003,"d":"0.04"},10,{"v":0.012,"d":"0.01"},{"v":0,"d":"0.00"},{"v":0.026000000000000002,"d":"0.03"},10,{"v":0.003,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0.009000000000000001,"d":"0.01"},8,{"v":0.094,"d":"0.09"},0.06,{"v":0.128,"d":"0.13"},10]
["B4GALT1",{"v":0.062,"d":"0.06"},{"v":0.048,"d":"0.05"},{"v":0.076,"d":"0.08"},50,0.01,{"v":0.006,"d":"0.01"},{"v":0.015,"d":"0.02"},49,{"v":0.013000000000000001,"d":"0.01"},0.01,{"v":0.016,"d":"0.02"},52,{"v":0.024,"d":"0.02"},{"v":0.018000000000000002,"d":"0.02"},0.03,53,{"v":0.027,"d":"0.03"},{"v":0.022,"d":"0.02"},{"v":0.031,"d":"0.03"},49,{"v":0.116,"d":"0.12"},{"v":0.08700000000000001,"d":"0.09"},{"v":0.145,"d":"0.15"},46,{"v":0.036000000000000004,"d":"0.04"},{"v":0.025,"d":"0.03"},{"v":0.046,"d":"0.05"},36]
["B4GALT2",{"v":0.037,"d":"0.04"},{"v":0.023,"d":"0.02"},{"v":0.051000000000000004,"d":"0.05"},40,{"v":0.041,"d":"0.04"},{"v":0.029,"d":"0.03"},{"v":0.053,"d":"0.05"},42,{"v":0.012,"d":"0.01"},{"v":0.008,"d":"0.01"},{"v":0.015,"d":"0.02"},40,{"v":0.006,"d":"0.01"},{"v":0.003,"d":"0.00"},{"v":0.009000000000000001,"d":"0.01"},41,{"v":0.029,"d":"0.03"},{"v":0.022,"d":"0.02"},{"v":0.035,"d":"0.04"},40,{"v":0.073,"d":"0.07"},{"v":0.039,"d":"0.04"},{"v":0.106,"d":"0.11"},34,{"v":0.085,"d":"0.09"},{"v":0.062,"d":"0.06"},{"v":0.108,"d":"0.11"},34]
["B4GALT3",{"v":0.061,"d":"0.06"},{"v":0.039,"d":"0.04"},{"v":0.082,"d":"0.08"},29,{"v":0.005,"d":"0.01"},{"v":0.002,"d":"0.00"},{"v":0.009000000000000001,"d":"0.01"},39,{"v":0.006,"d":"0.01"},{"v":0.003,"d":"0.00"},{"v":0.009000000000000001,"d":"0.01"},42,{"v":0.013000000000000001,"d":"0.01"},{"v":0.009000000000000001,"d":"0.01"},{"v":0.017,"d":"0.02"},41,{"v":0.011,"d":"0.01"},{"v":0.007,"d":"0.01"},{"v":0.015,"d":"0.02"},37,{"v":0.059000000000000004,"d":"0.06"},{"v":0.033,"d":"0.03"},{"v":0.085,"d":"0.09"},32,{"v":0.097,"d":"0.10"},{"v":0.069,"d":"0.07"},{"v":0.125,"d":"0.13"},35]
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["RPN1",{"v":0.045,"d":"0.05"},0.03,0.06,24,0.02,{"v":0.006,"d":"0.01"},{"v":0.033,"d":"0.03"},25,{"v":0.006,"d":"0.01"},{"v":0.003,"d":"0.00"},0.01,24,{"v":0.012,"d":"0.01"},{"v":0.007,"d":"0.01"},{"v":0.016,"d":"0.02"},23,{"v":0.012,"d":"0.01"},{"v":0.007,"d":"0.01"},{"v":0.017,"d":"0.02"},23,0.14,{"v":0.058,"d":"0.06"},{"v":0.221,"d":"0.22"},23,{"v":0.084,"d":"0.08"},{"v":0.044,"d":"0.04"},{"v":0.125,"d":"0.13"},23]
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["ST3GAL4",0.09,{"v":0.068,"d":"0.07"},{"v":0.112,"d":"0.11"},43,{"v":0.008,"d":"0.01"},{"v":0.004,"d":"0.00"},{"v":0.012,"d":"0.01"},54,{"v":0.012,"d":"0.01"},{"v":0.008,"d":"0.01"},{"v":0.016,"d":"0.02"},55,{"v":0.032,"d":"0.03"},{"v":0.022,"d":"0.02"},{"v":0.042,"d":"0.04"},57,0.01,{"v":0.007,"d":"0.01"},{"v":0.013000000000000001,"d":"0.01"},50,{"v":0.047,"d":"0.05"},{"v":0.029,"d":"0.03"},{"v":0.065,"d":"0.07"},46,{"v":0.085,"d":"0.09"},{"v":0.07200000000000001,"d":"0.07"},{"v":0.098,"d":"0.10"},43]
["ST6GAL1",{"v":0.038,"d":"0.04"},{"v":0.026000000000000002,"d":"0.03"},{"v":0.049,"d":"0.05"},67,{"v":0.019,"d":"0.02"},{"v":0.013000000000000001,"d":"0.01"},{"v":0.024,"d":"0.02"},68,0.01,{"v":0.007,"d":"0.01"},{"v":0.014,"d":"0.01"},71,{"v":0.009000000000000001,"d":"0.01"},{"v":0.005,"d":"0.01"},{"v":0.013000000000000001,"d":"0.01"},69,{"v":0.017,"d":"0.02"},{"v":0.014,"d":"0.01"},{"v":0.021,"d":"0.02"},71,{"v":0.089,"d":"0.09"},{"v":0.064,"d":"0.06"},{"v":0.113,"d":"0.11"},54,{"v":0.078,"d":"0.08"},{"v":0.059000000000000004,"d":"0.06"},{"v":0.097,"d":"0.10"},58]
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["STT3B",{"v":0.021,"d":"0.02"},{"v":0.011,"d":"0.01"},{"v":0.032,"d":"0.03"},30,{"v":0.015,"d":"0.02"},{"v":0.009000000000000001,"d":"0.01"},{"v":0.021,"d":"0.02"},31,{"v":0.017,"d":"0.02"},{"v":0.011,"d":"0.01"},{"v":0.023,"d":"0.02"},31,{"v":0.029,"d":"0.03"},0.02,{"v":0.038,"d":"0.04"},32,{"v":0.009000000000000001,"d":"0.01"},{"v":0.005,"d":"0.01"},{"v":0.013000000000000001,"d":"0.01"},29,{"v":0.168,"d":"0.17"},{"v":0.069,"d":"0.07"},{"v":0.268,"d":"0.27"},22,{"v":0.116,"d":"0.12"},0.09,{"v":0.14300000000000002,"d":"0.14"},23]
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["UGCGL1",{"v":0.052000000000000005,"d":"0.05"},{"v":0.027,"d":"0.03"},{"v":0.077,"d":"0.08"},21,{"v":0.033,"d":"0.03"},0.02,{"v":0.045,"d":"0.05"},22,0.02,{"v":0.009000000000000001,"d":"0.01"},{"v":0.031,"d":"0.03"},20,0.01,{"v":0.006,"d":"0.01"},{"v":0.013000000000000001,"d":"0.01"},24,{"v":0.022,"d":"0.02"},{"v":0.016,"d":"0.02"},{"v":0.029,"d":"0.03"},18,{"v":0.131,"d":"0.13"},{"v":0.08600000000000001,"d":"0.09"},{"v":0.176,"d":"0.18"},12,{"v":0.114,"d":"0.11"},{"v":0.085,"d":"0.09"},{"v":0.14400000000000002,"d":"0.14"},20]
["UGCGL2",{"v":0.053,"d":"0.05"},{"v":0.034,"d":"0.03"},{"v":0.07100000000000001,"d":"0.07"},18,{"v":0.015,"d":"0.02"},{"v":0.009000000000000001,"d":"0.01"},{"v":0.021,"d":"0.02"},19,{"v":0.016,"d":"0.02"},{"v":0.008,"d":"0.01"},{"v":0.024,"d":"0.02"},18,{"v":0.011,"d":"0.01"},{"v":0.005,"d":"0.01"},{"v":0.018000000000000002,"d":"0.02"},19,{"v":0.021,"d":"0.02"},{"v":0.015,"d":"0.02"},{"v":0.027,"d":"0.03"},19,0.13,{"v":0.078,"d":"0.08"},{"v":0.183,"d":"0.18"},15,{"v":0.003,"d":"0.00"},{"v":0.001,"d":"0.00"},{"v":0.005,"d":"0.01"},10]

{"sheet":"Table S4 Fst combined p-values","index":3,"n_rows":74,"n_cols":17,"rows_kept":74,"merged":[[2,3,2,4],[2,5,2,6],[2,7,2,8],[2,9,2,10],[2,11,2,12],[2,13,2,14],[2,15,2,16],[4,0,14,0],[4,1,28,1],[15,0,21,0],[22,0,28,0],[29,0,38,0],[29,1,49,1],[39,0,49,0],[50,0,60,0],[50,1,60,1]],"flags":["formulas_cached_only"]}
["Table S4: Z scores and combined p-values for FST estimates of all SNPs within a gene region ± 100 kb for all genes of Asparagine N-Glycosylation pathway. Significance is calculated by outlier method using a genomic distribution (0.05 cut-offs) calculated per population, are shown below."]
[]
[{"$nulls":3},"SSAFR",null,"MENA",null,"EUR",null,"CSASIA",null,"EASIA",null,"AME",null,"OCE"]
["Sub-pathway","Position (relative to \nCalnexin/Calreticulin Cycle)","gene","z","p","z","p","z","p","z","p","z","p","z","p","z","p"]
["Precursor \n Biosynthesis","Upstream","ALG1",72.7,{"v":0.389,"d":"0.39"},103.21,{"v":0.014100000000000001,"d":"0.01"},39.54,{"v":0.999,"d":"1.00"},64.9,{"v":0.7120000000000001,"d":"0.71"},35.8,{"v":0.998,"d":"1.00"},45.12,{"v":0.9470000000000001,"d":"0.95"},76.75,{"v":0.022600000000000002,"d":"0.02"}]
[null,null,"ALG11",33.9,{"v":0.907,"d":"0.91"},52.34,{"v":0.309,"d":"0.31"},56.12,{"v":0.197,"d":"0.20"},16.5,{"v":1,"d":"1.00"},55.19,{"v":0.12000000000000001,"d":"0.12"},57.18,{"v":0.125,"d":"0.13"},75.9,{"v":0.002,"d":"0.00"}]
[null,null,"ALG12",53,{"v":0.034,"d":"0.03"},30.29,0.65,18.76,{"v":0.9840000000000001,"d":"0.98"},56.6,{"v":0.0088,"d":"0.01"},14.1,{"v":0.994,"d":"0.99"},15.84,{"v":0.9840000000000001,"d":"0.98"},12.49,{"v":0.9740000000000001,"d":"0.97"}]
[null,null,"ALG14",55,{"v":0.9520000000000001,"d":"0.95"},103.44,{"v":0.040100000000000004,"d":"0.04"},135.1,{"v":0.0001,"d":"0.00"},63.9,{"v":0.906,"d":"0.91"},51.21,{"v":0.9800000000000001,"d":"0.98"},87.25,{"v":0.0028,"d":"0.00"},64.58,{"v":0.258,"d":"0.26"}]
[null,null,"ALG2",93.9,{"v":0.10600000000000001,"d":"0.11"},63.34,{"v":0.757,"d":"0.76"},52.88,{"v":0.937,"d":"0.94"},66.2,{"v":0.333,"d":"0.33"},47.83,{"v":0.639,"d":"0.64"},64.85,{"v":0.447,"d":"0.45"},34.11,{"v":0.132,"d":"0.13"}]
[null,null,"ALG3",35,{"v":0.9460000000000001,"d":"0.95"},44.84,{"v":0.9670000000000001,"d":"0.97"},64.15,0.61,70.4,{"v":0.334,"d":"0.33"},89.18,{"v":0.001,"d":"0.00"},51.29,{"v":0.274,"d":"0.27"},6.81,{"v":1,"d":"1.00"}]
[null,null,"ALG6",32.9,{"v":0.9700000000000001,"d":"0.97"},7.48,{"v":1,"d":"1.00"},35.5,{"v":0.991,"d":"0.99"},77,{"v":0.0946,"d":"0.09"},98.03,{"v":0.0008,"d":"0.00"},81.82,{"v":0.0086,"d":"0.01"},26.75,{"v":0.869,"d":"0.87"}]
[null,null,"ALG8",122.6,{"v":0.0009000000000000001,"d":"0.00"},86.81,{"v":0.395,"d":"0.40"},109.34,{"v":0.0455,"d":"0.05"},95.6,{"v":0.271,"d":"0.27"},124.44,{"v":0.0002,"d":"0.00"},39.08,{"v":0.994,"d":"0.99"},58.62,{"v":0.379,"d":"0.38"}]
[null,null,"ALG9",30.7,{"v":0.163,"d":"0.16"},13.83,0.95,17.54,{"v":0.892,"d":"0.89"},22.8,{"v":0.29700000000000004,"d":"0.30"},17.2,0.64,19.96,{"v":0.461,"d":"0.46"},0.98,{"v":1,"d":"1.00"}]
[null,null,"DPAGT1",85.3,{"v":0.0043,"d":"0.00"},35.14,{"v":0.992,"d":"0.99"},65.08,{"v":0.304,"d":"0.30"},74.5,0.05,78.25,{"v":0.010700000000000001,"d":"0.01"},84.36,{"v":5.2499999999999995e-05,"d":"0.00"},66.19,{"v":0.016900000000000002,"d":"0.02"}]
[null,null,"RFT1",45.4,{"v":0.994,"d":"0.99"},66.78,{"v":0.8140000000000001,"d":"0.81"},91.77,{"v":0.10500000000000001,"d":"0.11"},50.5,{"v":0.9890000000000001,"d":"0.99"},38.45,{"v":1,"d":"1.00"},34.96,{"v":0.998,"d":"1.00"},66.01,{"v":0.613,"d":"0.61"}]
["OST complex",null,"DAD1",204.2,{"v":0.259,"d":"0.26"},228.71,{"v":0.0956,"d":"0.10"},124.59,{"v":1,"d":"1.00"},190.6,{"v":0.634,"d":"0.63"},112.67,{"v":1,"d":"1.00"},188.21,{"v":0.0078000000000000005,"d":"0.01"},73.16,{"v":1,"d":"1.00"}]
[null,null,"DDOST",113.7,{"v":0.10500000000000001,"d":"0.11"},33.74,{"v":1,"d":"1.00"},147.1,{"v":0.0004,"d":"0.00"},118.3,{"v":0.061200000000000004,"d":"0.06"},83.34,{"v":0.561,"d":"0.56"},50.2,{"v":0.9760000000000001,"d":"0.98"},41.81,{"v":1,"d":"1.00"}]
[null,null,"RPN1",49.1,{"v":0.42700000000000005,"d":"0.43"},54.64,{"v":0.303,"d":"0.30"},25.22,{"v":0.997,"d":"1.00"},21.6,{"v":0.999,"d":"1.00"},37.71,{"v":0.803,"d":"0.80"},41.83,{"v":0.648,"d":"0.65"},55.48,0.16]
[null,null,"RPN2",25.5,{"v":0.9790000000000001,"d":"0.98"},33.45,0.68,81.16,{"v":6.000000000000001e-05,"d":"0.00"},34.7,{"v":0.622,"d":"0.62"},3.71,{"v":1,"d":"1.00"},8.86,{"v":0.994,"d":"0.99"},61.05,{"v":0.0007,"d":"0.00"}]
[null,null,"STT3A",84.6,{"v":0.0298,"d":"0.03"},88.01,{"v":0.0166,"d":"0.02"},97.05,{"v":0.0017000000000000001,"d":"0.00"},37.3,{"v":0.9840000000000001,"d":"0.98"},6.35,{"v":1,"d":"1.00"},57.7,{"v":0.0123,"d":"0.01"},9.55,{"v":1,"d":"1.00"}]
[null,null,"STT3B",33.4,{"v":0.998,"d":"1.00"},55.37,{"v":0.7110000000000001,"d":"0.71"},71.49,{"v":0.192,"d":"0.19"},75.7,0.15,36.95,{"v":0.9860000000000001,"d":"0.99"},55.53,{"v":0.158,"d":"0.16"},64.35,{"v":0.024300000000000002,"d":"0.02"}]
[null,null,"TUSC3",63,{"v":1,"d":"1.00"},160.2,{"v":0.116,"d":"0.12"},200.64,{"v":0.0004,"d":"0.00"},57.9,{"v":1,"d":"1.00"},166.21,{"v":0.0646,"d":"0.06"},96.95,{"v":0.9540000000000001,"d":"0.95"},71.16,{"v":0.9620000000000001,"d":"0.96"}]
["CNX_CRT",null,"EDEM3",45.5,{"v":0.49400000000000005,"d":"0.49"},19.65,{"v":1,"d":"1.00"},25.25,{"v":1,"d":"1.00"},38.8,{"v":0.912,"d":"0.91"},35.82,{"v":0.903,"d":"0.90"},23.19,{"v":1,"d":"1.00"},17.05,{"v":1,"d":"1.00"}]
[null,null,"GANAB",32,{"v":0.0779,"d":"0.08"},11.25,{"v":0.995,"d":"1.00"},12.9,{"v":0.9850000000000001,"d":"0.99"},12.9,{"v":0.9680000000000001,"d":"0.97"},13.83,{"v":0.8390000000000001,"d":"0.84"},16.75,{"v":0.159,"d":"0.16"},7.28,{"v":0.9880000000000001,"d":"0.99"}]
[null,null,"GCS1",27,0.41,48.25,{"v":0.0024000000000000002,"d":"0.00"},11.86,{"v":0.9600000000000001,"d":"0.96"},42.3,{"v":0.0119,"d":"0.01"},37.24,{"v":0.0414,"d":"0.04"},12.33,{"v":0.5800000000000001,"d":"0.58"},1.09,{"v":1,"d":"1.00"}]
[null,null,"MAN1B1",46.3,{"v":0.0292,"d":"0.03"},61.53,{"v":0.0013000000000000002,"d":"0.00"},21.44,{"v":0.874,"d":"0.87"},13.5,{"v":0.991,"d":"0.99"},50.92,{"v":0.0051,"d":"0.01"},14.16,{"v":0.9860000000000001,"d":"0.99"},11.48,{"v":0.9850000000000001,"d":"0.99"}]
[null,null,"PRKCSH",35.1,{"v":0.605,"d":"0.61"},50.22,{"v":0.0886,"d":"0.09"},28.24,{"v":0.746,"d":"0.75"},24.6,{"v":0.9550000000000001,"d":"0.96"},39.11,{"v":0.251,"d":"0.25"},13.27,{"v":0.9810000000000001,"d":"0.98"},21.7,{"v":0.795,"d":"0.80"}]
[null,null,"UGCGL1",48.9,{"v":0.216,"d":"0.22"},76.81,{"v":0.0016,"d":"0.00"},53.85,{"v":0.07060000000000001,"d":"0.07"},22.7,{"v":0.999,"d":"1.00"},49.64,{"v":0.06470000000000001,"d":"0.06"},53.34,{"v":0.0771,"d":"0.08"},33.83,{"v":0.0877,"d":"0.09"}]
[null,null,"UGCGL2",41,{"v":0.259,"d":"0.26"},34.48,{"v":0.633,"d":"0.63"},38.72,{"v":0.34800000000000003,"d":"0.35"},18.8,{"v":0.996,"d":"1.00"},48.8,{"v":0.113,"d":"0.11"},1.35,{"v":1,"d":"1.00"},40.74,{"v":0.09140000000000001,"d":"0.09"}]
["Branching1","Downstream","FUT8",19.8,{"v":0.993,"d":"0.99"},25.28,{"v":0.9660000000000001,"d":"0.97"},51.67,{"v":0.10200000000000001,"d":"0.10"},69.3,{"v":0.0015,"d":"0.00"},25.29,{"v":0.909,"d":"0.91"},83.3,{"v":0.0001,"d":"0.00"},5.11,{"v":0.746,"d":"0.75"}]
[null,null,"MAN1A1",104.2,{"v":0.115,"d":"0.12"},120.75,{"v":0.059300000000000005,"d":"0.06"},75.04,{"v":0.9590000000000001,"d":"0.96"},55.9,{"v":1,"d":"1.00"},120.44,{"v":0.012400000000000001,"d":"0.01"},3.81,{"v":1,"d":"1.00"},116.01,{"v":2e-05,"d":"0.00"}]
[null,null,"MAN1A2",56.3,{"v":0.538,"d":"0.54"},35.21,{"v":0.992,"d":"0.99"},72.55,{"v":0.0947,"d":"0.09"},48,{"v":0.769,"d":"0.77"},45.95,{"v":0.637,"d":"0.64"},25.12,{"v":0.9900000000000001,"d":"0.99"},33.05,{"v":0.514,"d":"0.51"}]
[null,null,"MAN1C1",39.3,{"v":0.861,"d":"0.86"},45.9,{"v":0.559,"d":"0.56"},50.64,{"v":0.12100000000000001,"d":"0.12"},33.3,{"v":0.8290000000000001,"d":"0.83"},10.18,{"v":1,"d":"1.00"},59.67,{"v":0.0079,"d":"0.01"},36.05,{"v":0.649,"d":"0.65"}]
[null,null,"MAN2A1",108.5,{"v":0.0086,"d":"0.01"},106.94,{"v":0.0627,"d":"0.06"},40.76,{"v":1,"d":"1.00"},109.5,{"v":0.007200000000000001,"d":"0.01"},11.96,{"v":1,"d":"1.00"},61.52,{"v":0.49300000000000005,"d":"0.49"},26.63,{"v":1,"d":"1.00"}]
[null,null,"MAN2A2",51.7,{"v":0.9850000000000001,"d":"0.99"},63.98,{"v":0.9490000000000001,"d":"0.95"},86.5,{"v":0.465,"d":"0.47"},208.7,{"v":3e-12,"d":"3.00E-12"},34.33,{"v":0.997,"d":"1.00"},38.31,{"v":0.547,"d":"0.55"},49.19,{"v":0.5850000000000001,"d":"0.59"}]
[null,null,"MGAT1",57,{"v":0.439,"d":"0.44"},17.35,{"v":1,"d":"1.00"},35.93,{"v":0.9720000000000001,"d":"0.97"},59.1,{"v":0.437,"d":"0.44"},34.82,{"v":0.9880000000000001,"d":"0.99"},53.16,{"v":0.42900000000000005,"d":"0.43"},31.33,{"v":0.9820000000000001,"d":"0.98"}]
[null,null,"MGAT2",52.9,{"v":0.36200000000000004,"d":"0.36"},81.25,{"v":0.0059,"d":"0.01"},32,{"v":0.9870000000000001,"d":"0.99"},43.9,{"v":0.782,"d":"0.78"},29.23,{"v":0.506,"d":"0.51"},21.21,{"v":0.999,"d":"1.00"},0.87,{"v":1,"d":"1.00"}]
[null,null,"MGAT3",39.3,{"v":0.9890000000000001,"d":"0.99"},56.77,{"v":0.873,"d":"0.87"},64.03,{"v":0.789,"d":"0.79"},157.7,{"v":2e-08,"d":"2.00E-08"},70.32,{"v":0.0011,"d":"0.00"},83.46,{"v":0.0001,"d":"0.00"},39.8,{"v":0.228,"d":"0.23"}]
[null,null,"MGAT5",90.5,{"v":0.993,"d":"0.99"},115.76,{"v":0.24300000000000002,"d":"0.24"},157.33,{"v":0.0002,"d":"0.00"},79.7,{"v":0.9870000000000001,"d":"0.99"},75.66,{"v":0.998,"d":"1.00"},67.82,{"v":0.9720000000000001,"d":"0.97"},78.62,{"v":0.9590000000000001,"d":"0.96"}]
["Branching2",null,"B4GALT1",142.2,{"v":0.0035,"d":"0.00"},62.88,{"v":0.998,"d":"1.00"},98.92,{"v":0.622,"d":"0.62"},104.3,{"v":0.527,"d":"0.53"},155.83,{"v":0.0002,"d":"0.00"},29.55,{"v":1,"d":"1.00"},98.06,{"v":0.313,"d":"0.31"}]
[null,null,"B4GALT2",72.3,{"v":0.7180000000000001,"d":"0.72"},166.84,{"v":2e-07,"d":"2.00E-07"},67.28,{"v":0.8440000000000001,"d":"0.84"},22.5,{"v":1,"d":"1.00"},136.11,{"v":0.0001,"d":"0.00"},69.81,{"v":0.41600000000000004,"d":"0.42"},49.28,{"v":0.9580000000000001,"d":"0.96"}]
[null,null,"B4GALT3",81.5,{"v":0.0228,"d":"0.02"},30.7,{"v":1,"d":"1.00"},43.55,{"v":1,"d":"1.00"},45.3,{"v":1,"d":"1.00"},54.71,{"v":0.9550000000000001,"d":"0.96"},77.72,{"v":0.24600000000000002,"d":"0.25"},39.04,{"v":0.994,"d":"0.99"}]
[null,null,"MGAT4A",116.2,{"v":2e-05,"d":"0.00"},50.85,{"v":0.916,"d":"0.92"},126.26,{"v":3e-06,"d":"3.00E-06"},10.8,{"v":1,"d":"1.00"},119.86,{"v":3e-06,"d":"3.00E-06"},17.13,{"v":1,"d":"1.00"},20.98,{"v":0.997,"d":"1.00"}]
[null,null,"MGAT4B",28.1,{"v":0.922,"d":"0.92"},38.65,0.83,39.85,{"v":0.792,"d":"0.79"},79.1,{"v":0.0031000000000000003,"d":"0.00"},70.49,{"v":0.0068000000000000005,"d":"0.01"},18.51,0.95,18.64,{"v":0.998,"d":"1.00"}]
[null,null,"MGAT5B",145.9,{"v":0.625,"d":"0.63"},179.67,{"v":0.114,"d":"0.11"},147.68,{"v":0.7110000000000001,"d":"0.71"},206.3,{"v":0.0106,"d":"0.01"},111.86,{"v":0.9880000000000001,"d":"0.99"},167.38,{"v":0.0716,"d":"0.07"},91.81,{"v":0.995,"d":"1.00"}]
[null,null,"ST3GAL4",168.7,{"v":3e-07,"d":"3.00E-07"},50.57,{"v":1,"d":"1.00"},91.94,{"v":0.894,"d":"0.89"},145.6,{"v":0.0245,"d":"0.02"},64.56,{"v":0.998,"d":"1.00"},75,{"v":0.796,"d":"0.80"},48.47,{"v":1,"d":"1.00"}]
[null,null,"ST6GAL1",112,{"v":0.917,"d":"0.92"},134.49,0.52,104.42,{"v":0.992,"d":"0.99"},53.7,{"v":1,"d":"1.00"},157.8,{"v":0.17300000000000001,"d":"0.17"},101.22,{"v":0.8340000000000001,"d":"0.83"},93.54,{"v":0.8380000000000001,"d":"0.84"}]
[null,null,"ST8SIA2",196.4,{"v":0.28600000000000003,"d":"0.29"},146.69,{"v":0.9800000000000001,"d":"0.98"},111.94,{"v":1,"d":"1.00"},182.7,{"v":0.555,"d":"0.56"},192.97,{"v":0.0745,"d":"0.07"},173.16,{"v":0.0492,"d":"0.05"},180.87,{"v":0.20400000000000001,"d":"0.20"}]
[null,null,"ST8SIA3",61.9,{"v":0.687,"d":"0.69"},60.2,{"v":0.612,"d":"0.61"},136.23,{"v":2e-07,"d":"2.00E-07"},76.1,{"v":0.186,"d":"0.19"},49.32,{"v":0.42000000000000004,"d":"0.42"},43.76,{"v":0.647,"d":"0.65"},44.4,{"v":0.0439,"d":"0.04"}]
[null,null,"ST8SIA6",97.4,{"v":0.9720000000000001,"d":"0.97"},154.66,{"v":0.013300000000000001,"d":"0.01"},178.8,{"v":0.0001,"d":"0.00"},198.5,{"v":3e-06,"d":"3.00E-06"},90.48,{"v":0.888,"d":"0.89"},59.9,{"v":1,"d":"1.00"},81.11,{"v":0.994,"d":"0.99"}]
["substrates",null,"ALG5",59.4,{"v":0.125,"d":"0.13"},58.33,{"v":0.0482,"d":"0.05"},36.14,{"v":0.794,"d":"0.79"},33.5,{"v":0.756,"d":"0.76"},49.27,{"v":0.0262,"d":"0.03"},20.61,{"v":0.995,"d":"1.00"},28.14,{"v":0.10600000000000001,"d":"0.11"}]
[null,null,"DOLK",46.4,{"v":0.0082,"d":"0.01"},10.75,{"v":1,"d":"1.00"},29.06,{"v":0.787,"d":"0.79"},18.6,{"v":0.9720000000000001,"d":"0.97"},37.61,{"v":0.228,"d":"0.23"},10,{"v":0.999,"d":"1.00"},24.74,{"v":0.8170000000000001,"d":"0.82"}]
[null,null,"DOLPP1",57.1,{"v":0.0603,"d":"0.06"},14.73,{"v":1,"d":"1.00"},19.42,{"v":1,"d":"1.00"},24.4,{"v":0.998,"d":"1.00"},39.94,{"v":0.8450000000000001,"d":"0.85"},13.95,{"v":1,"d":"1.00"},27.71,{"v":0.996,"d":"1.00"}]
[null,null,"DPM1",84.3,{"v":0.8370000000000001,"d":"0.84"},193.87,{"v":3.0000000000000004e-08,"d":"3.00E-08"},65.54,{"v":0.9650000000000001,"d":"0.97"},44.9,{"v":1,"d":"1.00"},28.9,{"v":1,"d":"1.00"},83.57,{"v":0.614,"d":"0.61"},49.47,{"v":1,"d":"1.00"}]
[null,null,"DPM2",45.4,{"v":0.9900000000000001,"d":"0.99"},29.97,{"v":1,"d":"1.00"},52.28,{"v":0.616,"d":"0.62"},61.1,{"v":0.768,"d":"0.77"},58.08,{"v":0.799,"d":"0.80"},59.5,{"v":0.49400000000000005,"d":"0.49"},15.56,{"v":1,"d":"1.00"}]
[null,null,"DPM3",80.6,{"v":0.0039000000000000003,"d":"0.00"},48.42,{"v":0.754,"d":"0.75"},45.14,{"v":0.8500000000000001,"d":"0.85"},235.5,{"v":2e-24,"d":"2.00E-24"},31.36,{"v":0.924,"d":"0.92"},51.04,{"v":0.35500000000000004,"d":"0.36"},17.16,{"v":1,"d":"1.00"}]
[null,null,"GMPPA",50.4,{"v":0.684,"d":"0.68"},63.96,{"v":0.12300000000000001,"d":"0.12"},41.47,{"v":0.8520000000000001,"d":"0.85"},43.1,{"v":0.805,"d":"0.81"},19.02,{"v":1,"d":"1.00"},100.62,{"v":0.0001,"d":"0.00"},65.06,{"v":0.0746,"d":"0.07"}]
[null,null,"PGM3",45.3,{"v":0.794,"d":"0.79"},62.69,{"v":0.381,"d":"0.38"},39.18,{"v":0.935,"d":"0.94"},47.8,{"v":0.872,"d":"0.87"},25.49,{"v":1,"d":"1.00"},45.27,{"v":0.795,"d":"0.80"},64.25,{"v":0.0026000000000000003,"d":"0.00"}]
[null,null,"PMM1",67.4,{"v":0.0012000000000000001,"d":"0.00"},23.72,{"v":0.8540000000000001,"d":"0.85"},19.08,{"v":0.896,"d":"0.90"},39.9,{"v":0.226,"d":"0.23"},85.82,{"v":8e-07,"d":"8.00E-07"},32.02,{"v":0.0099,"d":"0.01"},7.46,{"v":0.915,"d":"0.92"}]
[null,null,"PMM2",103,{"v":0.934,"d":"0.93"},175.88,{"v":0.0064,"d":"0.01"},91.35,{"v":0.991,"d":"0.99"},76.6,{"v":0.999,"d":"1.00"},33.84,{"v":1,"d":"1.00"},88.86,0.91,111.1,{"v":0.0651,"d":"0.07"}]
[null,null,"UAP1",61.8,{"v":0.554,"d":"0.55"},33.77,{"v":0.999,"d":"1.00"},51.51,0.87,47.2,{"v":0.9890000000000001,"d":"0.99"},68.33,{"v":0.333,"d":"0.33"},46.26,{"v":0.932,"d":"0.93"},9.75,{"v":1,"d":"1.00"}]
["other",null,"MANEA",82.1,{"v":0.35300000000000004,"d":"0.35"},56.93,0.87,52.38,{"v":0.9820000000000001,"d":"0.98"},61.9,{"v":0.9530000000000001,"d":"0.95"},65.66,{"v":0.48900000000000005,"d":"0.49"},76.52,{"v":0.277,"d":"0.28"},4.49,{"v":1,"d":"1.00"}]
[]
[]
[]
[]
[null,null,"P-value cutoffs by population"]
[null,null,"SSAFR","Fst",{"v":1.81123525529162e-05,"d":"1.81E-005"}]
[null,null,"MENA","Fst",{"v":2.4800548408536203e-05,"d":"2.48E-005"}]
[null,null,"EUR","Fst",{"v":2.5017931217970198e-05,"d":"2.50E-005"}]
[null,null,"CSASIA","Fst",{"v":6.789642932696241e-05,"d":"6.79E-005"}]
[null,null,"EASIA","Fst",{"v":1.91356336824993e-05,"d":"1.91E-005"}]
[null,null,"AME","Fst",{"v":5.16725654602285e-05,"d":"5.17E-005"}]
[null,null,"OCE","Fst",{"v":9.32329532045177e-06,"d":"9.32E-006"}]

{"sheet":"Table S5 mean iHS by gene","index":4,"n_rows":62,"n_cols":29,"rows_kept":62,"merged":[[2,1,2,4],[2,5,2,8],[2,9,2,12],[2,13,2,16],[2,17,2,20],[2,21,2,24],[2,25,2,28],[3,2,3,3],[3,6,3,7],[3,10,3,11],[3,14,3,15],[3,18,3,19],[3,22,3,23],[3,26,3,27]],"flags":["formulas_cached_only"]}
["Table S5: Mean iHS values per Gene, by Continental group. The mean iHS value is indicated for each gene region (gene ± 100 kb) along with lower and upper 95% confidence interval and the number of SNPs used."]
[]
[null,"SSAFR",{"$nulls":3},"MENA",{"$nulls":3},"EUR",{"$nulls":3},"CSASIA",{"$nulls":3},"EASIA",{"$nulls":3},"AME",{"$nulls":3},"OCE"]
["Gene","Mean","95% CI",null,"N","Mean","95% CI",null,"N","Mean","95% CI",null,"N","Mean","95% CI",null,"N","Mean","95% CI",null,"N","Mean","95% CI",null,"N","Mean","95% CI",null,"N"]
["ALG1",0.73,0.54,0.93,33,0.58,0.45,0.71,35,0.65,0.48,0.82,34,0.59,0.41,0.76,34,0.63,0.45,0.81,30,0.7,0.47,0.94,29,0.92,0.59,1.25,25]
["ALG11",1.18,0.79,1.57,22,1.07,0.86,1.27,23,1.1400000000000001,0.99,1.29,23,0.87,0.67,1.06,24,0.37,0.23,0.51,21,0.86,0.6,1.12,22,0.72,0.5700000000000001,0.86,22]
["ALG12",0.58,0.36,0.8,18,1.9500000000000002,1.44,2.46,17,1.98,1.53,2.44,17,1.43,1.03,1.83,17,2.03,1.36,2.71,15,0.38,0.21,0.55,15,0.73,0.43,1.02,13]
["ALG14",0.6,0.41,0.79,35,1.16,0.92,1.4,38,1.07,0.86,1.27,38,1.03,0.78,1.28,37,1.03,0.81,1.24,35,0.83,0.5700000000000001,1.09,25,0.72,0.5700000000000001,0.88,27]
["ALG2",0.76,0.55,0.96,36,0.95,0.74,1.15,33,0.78,0.5700000000000001,0.99,32,0.74,0.53,0.96,31,0.65,0.53,0.76,25,1.19,0.88,1.49,31,0.75,0.42,1.07,12]
["ALG3",0.92,0.65,1.18,23,0.58,0.44,0.72,30,0.67,0.44,0.89,32,0.7,0.47,0.92,32,0.68,0.5,0.86,25,1.13,0.81,1.45,22,0.92,0.56,1.28,12]
["ALG5",0.69,0.49,0.88,24,0.7,0.48,0.91,21,0.8,0.59,1.02,21,0.68,0.52,0.84,21,0.53,0.33,0.74,16,0.64,0.46,0.82,19,0.93,0.65,1.22,10]
["ALG6",0.9,0.63,1.17,25,0.83,0.61,1.06,27,0.77,0.56,0.97,28,0.81,0.61,1.02,28,0.79,0.5700000000000001,1.01,28,0.82,0.56,1.08,26,0.55,0.31,0.79,17]
["ALG8",0.9,0.69,1.11,39,0.54,0.41,0.67,42,0.65,0.54,0.77,43,0.56,0.41,0.71,44,0.71,0.54,0.88,37,0.69,0.5,0.88,32,0.64,0.49,0.79,28]
["ALG9",1.26,0.92,1.6,12,0.71,0.35,1.06,12,0.73,0.36,1.1,13,0.49,0.19,0.79,11,0.38,0.18,0.58,10,0.46,0.27,0.66,10,1.01,0.54,1.49,8]
["B4GALT1",0.61,0.47,0.76,49,0.67,0.52,0.82,47,0.71,0.55,0.87,51,0.74,0.59,0.88,52,0.47,0.34,0.61,49,1.22,1.03,1.42,35,0.65,0.52,0.77,45]
["B4GALT2",0.88,0.68,1.08,39,0.54,0.39,0.7,41,0.77,0.6,0.93,39,0.78,0.61,0.96,41,0.5700000000000001,0.42,0.72,39,0.65,0.47,0.83,33,0.43,0.31,0.54,33]
["B4GALT3",1.04,0.79,1.3,29,0.61,0.44,0.78,39,0.69,0.52,0.86,42,0.72,0.51,0.93,40,0.67,0.53,0.81,37,0.8,0.65,0.95,35,0.69,0.49,0.89,32]
["DAD1",0.7,0.59,0.81,89,0.59,0.49,0.69,96,0.5700000000000001,0.46,0.67,92,0.65,0.53,0.77,94,0.77,0.65,0.9,85,0.75,0.6,0.91,70,0.95,0.8,1.1,68]
["DDOST",0.79,0.65,0.94,45,0.9,0.7,1.1,41,0.77,0.59,0.94,44,0.74,0.6,0.87,46,0.61,0.45,0.77,40,0.7,0.49,0.91,33,0.6,0.45,0.75,39]
["DOLK",0.89,0.31,1.47,12,0.54,0.31,0.77,15,0.73,0.47,0.99,16,0.7,0.44,0.97,14,0.51,0.37,0.64,14,0.92,0.62,1.23,12,0.63,0.35,0.92,14]
["DOLPP1",0.63,0.42,0.84,20,1,0.72,1.29,21,1.16,0.81,1.5,23,1.42,1.09,1.75,23,0.68,0.44,0.93,24,0.98,0.68,1.27,22,0.69,0.41,0.96,24]
["DPAGT1",0.8,0.54,1.07,24,0.53,0.37,0.7,26,0.64,0.45,0.83,27,0.67,0.49,0.85,26,0.84,0.67,1.01,23,0.65,0.37,0.93,18,0.48,0.39,0.58,19]
["DPM1",0.69,0.53,0.85,48,1.53,1.3,1.76,48,1.44,1.22,1.65,43,1.7000000000000002,1.44,1.97,45,0.92,0.74,1.1,45,0.65,0.53,0.78,43,0.99,0.79,1.19,44]
["DPM2",0.65,0.51,0.8,31,0.81,0.56,1.05,30,1.51,1.15,1.87,24,0.84,0.62,1.05,31,0.65,0.44,0.85,31,1.08,0.86,1.31,27,0.49,0.34,0.64,20]
["DPM3",0.45,0.31,0.6,25,0.82,0.62,1.02,28,0.75,0.55,0.94,28,0.5700000000000001,0.37,0.77,28,2.92,2.68,3.17,22,1.32,1.12,1.51,24,0.64,0.42,0.85,24]
["EDEM3",0.69,0.44,0.94,23,0.47,0.33,0.6,27,0.48,0.35,0.61,27,0.67,0.53,0.81,26,0.49,0.36,0.62,25,0.66,0.49,0.82,26,1.85,1.54,2.15,24]
["FUT8",1.4,0.91,1.89,17,1.03,0.7,1.36,18,1.04,0.76,1.32,18,1.09,0.72,1.46,18,0.93,0.63,1.24,15,1.03,0.83,1.22,17,0.37,-3.79,4.53,2]
["GANAB",2.05,1.71,2.38,11,0.51,0.35,0.67,13,0.58,0.38,0.77,13,0.82,0.51,1.13,13,0.5700000000000001,0.31,0.84,13,0.66,0.24,1.07,6,0.66,0.24,1.09,10]
["GCS1",0.64,0.29,0.99,13,2.57,1.9,3.25,12,2.83,2.2800000000000002,3.38,11,1.8,1.22,2.39,12,0.67,0.42,0.92,12,0.52,0.2,0.84,7,1,0.54,1.45,12]
["GMPPA",0.91,0.7,1.12,27,0.5,0.37,0.64,25,0.73,0.54,0.91,25,0.58,0.41,0.76,24,0.87,0.58,1.16,26,0.7,0.52,0.89,25,0.68,0.45,0.91,24]
["MAN1A1",0.67,0.5,0.83,44,0.75,0.59,0.92,49,0.61,0.48,0.74,49,0.71,0.58,0.85,49,0.83,0.67,0.98,46,1.66,1.47,1.86,43,0.39,0.33,0.46,30]
["MAN1A2",1.17,0.83,1.51,28,1.22,0.94,1.5,28,1.16,0.89,1.44,28,1.02,0.78,1.27,27,0.41,0.27,0.54,24,0.37,0.25,0.48,21,0.53,0.38,0.69,16]
["MAN1B1",1.31,0.91,1.71,14,0.54,0.34,0.75,15,0.47,0.3,0.64,14,0.69,0.45,0.93,14,1.12,0.82,1.42,13,0.5,0.31,0.7,13,0.96,0.56,1.36,11]
["MAN1C1",0.52,0.34,0.7,24,1.03,0.8,1.26,23,1.1,0.82,1.37,19,1.07,0.81,1.32,20,0.54,0.35,0.72,19,0.58,0.4,0.76,17,0.71,0.49,0.93,19]
["MAN2A1",2.13,1.72,2.5300000000000002,36,0.85,0.67,1.04,40,0.78,0.63,0.92,41,0.56,0.41,0.71,35,1.74,1.52,1.97,28,0.69,0.49,0.88,28,0.81,0.59,1.02,31]
["MAN2A2",0.63,0.47,0.79,38,0.78,0.58,0.98,42,0.6,0.47,0.74,43,0.66,0.5,0.81,43,0.63,0.46,0.8,32,0.43,0.29,0.58,20,0.65,0.47,0.84,26]
["MANEA",0.71,0.56,0.87,36,0.81,0.64,0.98,32,0.91,0.76,1.05,36,0.75,0.58,0.92,38,0.96,0.74,1.17,30,0.84,0.67,1.01,32,0.94,0.62,1.27,17]
["MGAT1",0.87,0.63,1.12,25,1.27,1,1.54,24,1.45,1.23,1.6800000000000002,24,0.79,0.5700000000000001,1,26,0.66,0.46,0.86,27,0.78,0.6,0.96,24,0.54,0.39,0.69,23]
["MGAT2",0.97,0.73,1.21,24,0.64,0.47,0.82,25,0.65,0.52,0.77,25,0.49,0.29,0.68,25,1.86,1.67,2.05,15,0.7,0.46,0.94,23,0.39,0.26,0.52,13]
["MGAT3",0.9,0.69,1.12,28,0.52,0.38,0.67,32,0.69,0.5,0.89,34,0.6,0.44,0.76,33,2.31,2.02,2.6,18,0.42,0.3,0.53,19,0.85,0.52,1.17,16]
["MGAT4A",0.93,0.7,1.16,28,0.5700000000000001,0.41,0.73,32,0.61,0.45,0.77,32,0.6,0.45,0.76,31,0.59,0.4,0.78,28,1.13,0.82,1.43,22,0.7,0.52,0.88,21]
["MGAT4B",0.74,0.49,0.98,19,0.76,0.53,0.98,23,0.71,0.46,0.96,23,0.56,0.37,0.76,23,0.54,0.39,0.69,21,0.69,0.38,0.99,14,1.12,0.76,1.48,19]
["MGAT5",0.61,0.5,0.73,59,0.62,0.46,0.79,48,0.9,0.74,1.07,46,0.94,0.74,1.13,49,0.5700000000000001,0.44,0.69,52,0.69,0.53,0.84,41,1.02,0.77,1.28,48]
["MGAT5B",0.62,0.52,0.72,70,1.2,1,1.39,72,1.2,1,1.39,72,0.72,0.61,0.83,74,0.6,0.51,0.69,68,0.87,0.72,1.03,65,0.79,0.64,0.94,59]
["PGM3",0.55,0.37,0.74,26,0.62,0.45,0.8,29,0.92,0.76,1.09,26,1.16,0.89,1.43,29,1.06,0.82,1.31,28,0.55,0.38,0.71,26,0.65,0.43,0.86,19]
["PMM1",0.68,0.42,0.93,18,0.98,0.63,1.33,15,0.83,0.51,1.15,13,1.01,0.68,1.34,15,0.71,0.47,0.95,15,0.92,0.64,1.2,7,1.39,0.75,2.03,6]
["PMM2",0.91,0.73,1.09,60,0.65,0.5,0.79,63,0.71,0.56,0.85,60,0.65,0.49,0.81,56,0.63,0.49,0.77,48,0.6,0.47,0.73,51,0.84,0.66,1.03,45]
["PRKCSH",0.73,0.44,1.02,18,1.15,0.81,1.48,18,1.04,0.69,1.4,16,1.19,0.82,1.56,18,0.71,0.51,0.9,16,0.35,0.2,0.51,13,0.53,0.33,0.73,13]
["RFT1",0.73,0.56,0.9,35,0.7,0.5700000000000001,0.82,38,0.71,0.56,0.87,37,0.77,0.61,0.93,37,0.71,0.54,0.87,35,0.64,0.42,0.86,27,0.59,0.4,0.78,34]
["RPN1",0.45,0.29,0.62,22,0.62,0.42,0.81,23,0.6,0.4,0.8,22,0.5,0.36,0.65,21,0.64,0.45,0.82,21,0.87,0.5700000000000001,1.18,21,1.05,0.74,1.35,21]
["RPN2",0.88,0.62,1.13,19,0.58,0.3,0.86,17,0.6,0.37,0.82,17,0.68,0.45,0.91,17,0.88,0.55,1.22,14,0.63,0.46,0.81,11,0.77,0.48,1.05,14]
["ST3GAL4",0.71,0.55,0.87,43,0.71,0.54,0.88,53,0.69,0.52,0.85,54,0.76,0.59,0.93,55,0.72,0.56,0.88,50,0.5,0.37,0.63,42,0.96,0.76,1.15,45]
["ST6GAL1",0.89,0.73,1.05,64,0.64,0.52,0.75,65,0.72,0.5700000000000001,0.87,68,0.67,0.55,0.78,66,0.67,0.55,0.79,68,0.64,0.51,0.77,55,0.5700000000000001,0.43,0.71,52]
["ST8SIA2",0.63,0.53,0.73,84,0.65,0.54,0.75,84,0.58,0.49,0.68,84,0.8,0.69,0.91,84,0.5,0.42,0.58,80,0.5700000000000001,0.45,0.68,67,0.69,0.5700000000000001,0.82,76]
["ST8SIA3",0.73,0.5700000000000001,0.88,33,1.56,1.19,1.9300000000000002,31,1.56,1.3,1.83,30,0.96,0.75,1.18,31,0.55,0.39,0.71,23,0.65,0.43,0.86,23,0.59,0.35,0.83,14]
["ST8SIA6",0.76,0.61,0.92,62,0.78,0.64,0.92,58,0.92,0.74,1.09,57,0.68,0.56,0.79,58,0.56,0.45,0.68,56,0.79,0.67,0.92,55,0.78,0.62,0.93,57]
["STT3A",0.7,0.51,0.89,29,0.85,0.63,1.08,29,0.84,0.66,1.01,28,0.68,0.51,0.85,28,0.88,0.51,1.25,18,0.86,0.5700000000000001,1.15,16,0.68,0.43,0.94,16]
["STT3B",0.78,0.54,1.02,29,0.6,0.42,0.77,30,0.64,0.48,0.8,30,0.87,0.67,1.08,30,0.55,0.35,0.75,26,1.45,1.22,1.6800000000000002,22,0.77,0.51,1.03,21]
["TUSC3",0.74,0.6,0.88,59,1.08,0.87,1.28,67,0.98,0.79,1.17,66,1.09,0.9,1.28,67,1.16,1,1.31,67,0.84,0.71,0.96,58,1.02,0.84,1.19,44]
["UAP1",0.93,0.75,1.12,30,0.59,0.4,0.79,29,0.48,0.34,0.63,29,0.59,0.43,0.75,33,0.65,0.47,0.83,30,0.7,0.48,0.91,28,0.62,0.43,0.81,24]
["UGCGL1",1.12,0.79,1.46,19,0.78,0.49,1.07,20,0.84,0.49,1.19,18,0.82,0.5700000000000001,1.08,22,0.87,0.54,1.19,18,1.21,0.83,1.59,19,0.92,0.5700000000000001,1.26,12]
["UGCGL2",1.5,1.13,1.87,18,1.08,0.64,1.53,19,0.87,0.45,1.29,18,1.1400000000000001,0.64,1.63,19,1.36,1.05,1.6800000000000002,19,0.65,0.5,0.79,10,0.96,0.56,1.36,15]

{"sheet":"Table S6 iHS combined p-values","index":5,"n_rows":75,"n_cols":17,"rows_kept":75,"merged":[[2,3,2,4],[2,5,2,6],[2,7,2,8],[2,9,2,10],[2,11,2,12],[2,13,2,14],[2,15,2,16],[4,0,14,0],[4,1,28,1],[15,0,21,0],[22,0,28,0],[29,0,38,0],[29,1,49,1],[39,0,49,0],[50,0,60,0],[50,1,60,1]],"flags":["formulas_cached_only"]}
["Table S6: Z scores and combined p values for iHS estimates of all SNPs within a gene region ± 100 kb for all genes of Asparagine N-Glycosylation pathway. Significance is calculated by outlier method using a genomic distribution (0.05 cut-offs) calculated per population, are shown below."]
[]
[{"$nulls":3},"SSAFR",null,"MENA",null,"EUR",null,"CSASIA",null,"EASIA",null,"AME",null,"OCE"]
["Sub-pathway","Position (relative to \nCalnexin/Calreticulin Cycle)","gene","z","p","z","p","z","p","z","p","z","p","z","p","z","p"]
["Precursor \n Biosynthesis","Upstream","ALG1",{"v":59.5,"d":"59.500"},{"v":0.7020000000000001,"d":"0.70"},{"v":44.4,"d":"44.400"},{"v":0.9930000000000001,"d":"0.99"},{"v":50.9,"d":"50.900"},0.94,{"v":45.9,"d":"45.900"},{"v":0.9820000000000001,"d":"0.98"},{"v":43.6,"d":"43.600"},{"v":0.9450000000000001,"d":"0.95"},{"v":50.67,"d":"50.670"},{"v":0.7420000000000001,"d":"0.74"},{"v":62.51,"d":"62.510"},{"v":0.11000000000000001,"d":"0.11"}]
[null,null,"ALG11",{"v":74.3,"d":"74.300"},{"v":0.0029200000000000003,"d":"0.00"},{"v":61.5,"d":"61.500"},{"v":0.062400000000000004,"d":"0.06"},{"v":64.9,"d":"64.900"},{"v":0.0344,"d":"0.03"},{"v":49.6,"d":"49.600"},{"v":0.41100000000000003,"d":"0.41"},{"v":15.8,"d":"15.800"},{"v":1,"d":"1.00"},{"v":47.47,"d":"47.470"},{"v":0.333,"d":"0.33"},{"v":35.43,"d":"35.430"},{"v":0.8180000000000001,"d":"0.82"}]
[null,null,"ALG12",{"v":23.4,"d":"23.400"},{"v":0.9470000000000001,"d":"0.95"},{"v":112.2,"d":"112.200"},{"v":3e-10,"d":"3.00E-10"},{"v":115.1,"d":"115.100"},{"v":1e-10,"d":"1.00E-10"},{"v":72,"d":"72.000"},{"v":0.00015000000000000001,"d":"0.00"},{"v":110,"d":"110.000"},{"v":4.9999999999999995e-11,"d":"5.00E-11"},{"v":11.65,"d":"11.650"},{"v":0.9990000000000001,"d":"1.00"},{"v":22.31,"d":"22.310"},{"v":0.672,"d":"0.67"}]
[null,null,"ALG14",{"v":50,"d":"50.000"},{"v":0.9660000000000001,"d":"0.97"},{"v":122.2,"d":"122.200"},{"v":0.0006100000000000001,"d":"0.00"},{"v":106.2,"d":"106.200"},{"v":0.012600000000000002,"d":"0.01"},{"v":105.1,"d":"105.100"},{"v":0.0102,"d":"0.01"},{"v":94.6,"d":"94.600"},{"v":0.026900000000000004,"d":"0.03"},{"v":52.69,"d":"52.690"},{"v":0.37000000000000005,"d":"0.37"},{"v":44.74,"d":"44.740"},{"v":0.811,"d":"0.81"}]
[null,null,"ALG2",{"v":67.8,"d":"67.800"},{"v":0.6180000000000001,"d":"0.62"},{"v":79.3,"d":"79.300"},{"v":0.126,"d":"0.13"},{"v":61.5,"d":"61.500"},{"v":0.5670000000000001,"d":"0.57"},{"v":56.6,"d":"56.600"},0.67,{"v":34.5,"d":"34.500"},{"v":0.9540000000000001,"d":"0.95"},{"v":106.87,"d":"106.870"},{"v":0.00035000000000000005,"d":"0.00"},{"v":21.31,"d":"21.310"},0.62]
[null,null,"ALG3",{"v":54.7,"d":"54.700"},{"v":0.17900000000000002,"d":"0.18"},{"v":38.1,"d":"38.100"},{"v":0.9880000000000001,"d":"0.99"},{"v":53.1,"d":"53.100"},{"v":0.8320000000000001,"d":"0.83"},{"v":55.3,"d":"55.300"},{"v":0.772,"d":"0.77"},{"v":38.7,"d":"38.700"},{"v":0.8770000000000001,"d":"0.88"},{"v":68.56,"d":"68.560"},{"v":0.0103,"d":"0.01"},{"v":27.86,"d":"27.860"},{"v":0.266,"d":"0.27"}]
[null,null,"ALG6",{"v":57.6,"d":"57.600"},{"v":0.21500000000000002,"d":"0.22"},{"v":55.9,"d":"55.900"},{"v":0.403,"d":"0.40"},{"v":51,"d":"51.000"},{"v":0.664,"d":"0.66"},{"v":54.8,"d":"54.800"},{"v":0.519,"d":"0.52"},{"v":54,"d":"54.000"},{"v":0.551,"d":"0.55"},{"v":54.6,"d":"54.600"},{"v":0.37600000000000006,"d":"0.38"},{"v":21.29,"d":"21.290"},{"v":0.9560000000000001,"d":"0.96"}]
[null,null,"ALG8",{"v":91.1,"d":"91.100"},{"v":0.14800000000000002,"d":"0.15"},{"v":49.7,"d":"49.700"},{"v":0.9990000000000001,"d":"1.00"},{"v":61.2,"d":"61.200"},{"v":0.9800000000000001,"d":"0.98"},{"v":56.3,"d":"56.300"},{"v":0.9970000000000001,"d":"1.00"},{"v":62.5,"d":"62.500"},{"v":0.8280000000000001,"d":"0.83"},{"v":52.18,"d":"52.180"},{"v":0.8550000000000001,"d":"0.86"},{"v":40.22,"d":"40.220"},{"v":0.9450000000000001,"d":"0.95"}]
[null,null,"ALG9",{"v":40.8,"d":"40.800"},{"v":0.0175,"d":"0.02"},{"v":20.4,"d":"20.400"},{"v":0.672,"d":"0.67"},{"v":23.3,"d":"23.300"},{"v":0.6140000000000001,"d":"0.61"},{"v":11.7,"d":"11.700"},{"v":0.9620000000000001,"d":"0.96"},{"v":7.6,"d":"7.600"},{"v":0.9940000000000001,"d":"0.99"},{"v":9.41,"d":"9.410"},{"v":0.9780000000000001,"d":"0.98"},{"v":20.6,"d":"20.600"},{"v":0.195,"d":"0.20"}]
[null,null,"DPAGT1",{"v":49,"d":"49.000"},{"v":0.43400000000000005,"d":"0.43"},{"v":30.5,"d":"30.500"},{"v":0.9930000000000001,"d":"0.99"},{"v":39.6,"d":"39.600"},{"v":0.929,"d":"0.93"},{"v":39.3,"d":"39.300"},{"v":0.903,"d":"0.90"},{"v":45.1,"d":"45.100"},{"v":0.509,"d":"0.51"},{"v":28,"d":"28.000"},{"v":0.8270000000000001,"d":"0.83"},{"v":18.61,"d":"18.610"},{"v":0.9970000000000001,"d":"1.00"}]
[null,null,"RFT1",{"v":60.8,"d":"60.800"},{"v":0.777,"d":"0.78"},{"v":59.2,"d":"59.200"},{"v":0.923,"d":"0.92"},{"v":60.9,"d":"60.900"},{"v":0.8640000000000001,"d":"0.86"},{"v":67.5,"d":"67.500"},0.69,{"v":57.9,"d":"57.900"},{"v":0.8480000000000001,"d":"0.85"},{"v":41.42,"d":"41.420"},{"v":0.895,"d":"0.90"},{"v":48.36,"d":"48.360"},{"v":0.9660000000000001,"d":"0.97"}]
["OST complex",null,"DAD1",{"v":149.2,"d":"149.200"},{"v":0.9430000000000001,"d":"0.94"},{"v":131.4,"d":"131.400"},{"v":1,"d":"1.00"},{"v":119.5,"d":"119.500"},{"v":1,"d":"1.00"},{"v":148.4,"d":"148.400"},{"v":0.9850000000000001,"d":"0.99"},{"v":162.8,"d":"162.800"},{"v":0.641,"d":"0.64"},{"v":134.53,"d":"134.530"},{"v":0.6150000000000001,"d":"0.62"},{"v":167.93,"d":"167.930"},{"v":0.0327,"d":"0.03"}]
[null,null,"DDOST",{"v":85.9,"d":"85.900"},{"v":0.6040000000000001,"d":"0.60"},{"v":95.4,"d":"95.400"},{"v":0.14900000000000002,"d":"0.15"},{"v":82.4,"d":"82.400"},0.65,{"v":78.3,"d":"78.300"},{"v":0.8450000000000001,"d":"0.85"},{"v":56.4,"d":"56.400"},{"v":0.9790000000000001,"d":"0.98"},{"v":56.95,"d":"56.950"},{"v":0.779,"d":"0.78"},{"v":53.93,"d":"53.930"},{"v":0.9830000000000001,"d":"0.98"}]
[null,null,"RPN1",{"v":21.1,"d":"21.100"},{"v":0.9990000000000001,"d":"1.00"},{"v":32.3,"d":"32.300"},{"v":0.937,"d":"0.94"},{"v":29.6,"d":"29.600"},{"v":0.9520000000000001,"d":"0.95"},{"v":21.8,"d":"21.800"},{"v":0.9960000000000001,"d":"1.00"},{"v":29.7,"d":"29.700"},{"v":0.924,"d":"0.92"},{"v":47.92,"d":"47.920"},{"v":0.24500000000000002,"d":"0.25"},{"v":58.71,"d":"58.710"},{"v":0.0449,"d":"0.04"}]
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[null,null,"PGM3",{"v":32.7,"d":"32.700"},{"v":0.9830000000000001,"d":"0.98"},{"v":41,"d":"41.000"},{"v":0.9550000000000001,"d":"0.96"},{"v":57.1,"d":"57.100"},{"v":0.29000000000000004,"d":"0.29"},{"v":92.8,"d":"92.800"},{"v":0.00253,"d":"0.00"},{"v":78.5,"d":"78.500"},{"v":0.0251,"d":"0.03"},{"v":31.2,"d":"31.200"},{"v":0.9900000000000001,"d":"0.99"},{"v":28.28,"d":"28.280"},{"v":0.8750000000000001,"d":"0.88"}]
[null,null,"PMM1",{"v":28.7,"d":"28.700"},{"v":0.801,"d":"0.80"},{"v":38,"d":"38.000"},{"v":0.15000000000000002,"d":"0.15"},{"v":26,"d":"26.000"},{"v":0.461,"d":"0.46"},{"v":38.9,"d":"38.900"},{"v":0.128,"d":"0.13"},{"v":24.4,"d":"24.400"},{"v":0.7530000000000001,"d":"0.75"},{"v":14.83,"d":"14.830"},0.39,{"v":23.22,"d":"23.220"},{"v":0.025900000000000003,"d":"0.03"}]
[null,null,"PMM2",{"v":144,"d":"144.000"},{"v":0.0671,"d":"0.07"},{"v":98.5,"d":"98.500"},{"v":0.9670000000000001,"d":"0.97"},{"v":102.4,"d":"102.400"},{"v":0.8760000000000001,"d":"0.88"},{"v":89.4,"d":"89.400"},{"v":0.9430000000000001,"d":"0.94"},{"v":69.4,"d":"69.400"},{"v":0.9810000000000001,"d":"0.98"},{"v":70.23,"d":"70.230"},{"v":0.9930000000000001,"d":"0.99"},{"v":97.05,"d":"97.050"},{"v":0.28700000000000003,"d":"0.29"}]
[null,null,"UAP1",{"v":69.8,"d":"69.800"},{"v":0.18100000000000002,"d":"0.18"},{"v":40.1,"d":"40.100"},{"v":0.9650000000000001,"d":"0.97"},{"v":29.8,"d":"29.800"},{"v":0.9990000000000001,"d":"1.00"},{"v":43.8,"d":"43.800"},{"v":0.9840000000000001,"d":"0.98"},{"v":45,"d":"45.000"},{"v":0.925,"d":"0.93"},{"v":47.1,"d":"47.100"},{"v":0.796,"d":"0.80"},{"v":34.28,"d":"34.280"},{"v":0.932,"d":"0.93"}]
["other",null,"MANEA",{"v":59.8,"d":"59.800"},{"v":0.8480000000000001,"d":"0.85"},{"v":61.6,"d":"61.600"},{"v":0.562,"d":"0.56"},{"v":77.6,"d":"77.600"},{"v":0.30600000000000005,"d":"0.31"},{"v":68,"d":"68.000"},{"v":0.7320000000000001,"d":"0.73"},{"v":72.6,"d":"72.600"},{"v":0.127,"d":"0.13"},{"v":63.79,"d":"63.790"},{"v":0.48400000000000004,"d":"0.48"},{"v":41.38,"d":"41.380"},{"v":0.18000000000000002,"d":"0.18"}]
[]
[]
[]
[]
[]
["P-value cutoffs by population"]
["SSAFR","iHS",{"v":0.000877725180850925,"d":"8.78E-004"},319]
["MENA","iHS",{"v":3.4313493368854006e-05,"d":"3.43E-005"},319]
["EUR","iHS",{"v":1.89038773560588e-05,"d":"1.89E-005"},318]
["CSASIA","iHS",{"v":3.16421726912383e-05,"d":"3.16E-005"},319]
["EASIA","iHS",{"v":2.6079238300796802e-05,"d":"2.61E-005"},318]
["AME","iHS",{"v":3.5891583667035804e-05,"d":"3.59E-005"},313]
["OCE","iHS",{"v":6.28711793251372e-05,"d":"6.29E-005"},315]

{"sheet":"Table S7 Mann-Whitney U test","index":6,"n_rows":18,"n_cols":11,"rows_kept":18,"flags":["formulas_cached_only"]}
["Table S7: Mann-Whitney U Test comparing upstream and downstream parts of the pathway"]
[]
["test","population","Rank Sum ","Rank Sum","U","Z","p-level","Valid N","Valid N","mean Z-values Upstream"," mean Z-values Downstream"]
["FST ","SSAFR",{"v":484,"d":"484.0000"},{"v":597,"d":"597.0000"},{"v":159,"d":"159.0000"},{"v":-2.282455884178681,"d":"-2.28246"},{"v":0.02246309056134561,"d":"2.25E-02"},25,21,{"v":60.38799999999999,"d":"60.39"},{"v":87.71904761904764,"d":"87.72"}]
["FST ","MENA",{"v":518,"d":"518.0000"},{"v":563,"d":"563.0000"},{"v":193,"d":"193.0000"},{"v":-1.5326636130475202,"d":"-1.53266"},{"v":0.12535977397359377,"d":"0.125360"},25,21,{"v":62.552400000000006,"d":"62.55"},{"v":83.11380952380954,"d":"83.11"}]
["FST ","EUR",{"v":499,"d":"499.0000"},{"v":582,"d":"582.0000"},{"v":174,"d":"174.0000"},{"v":-1.9516651763266983,"d":"-1.95167"},{"v":0.05097883276601017,"d":"0.050979"},25,21,{"v":65.0116,"d":"65.01"},{"v":86.34857142857143,"d":"86.35"}]
["FST ","CSASIA",{"v":484,"d":"484.0000"},{"v":597,"d":"597.0000"},{"v":159,"d":"159.0000"},{"v":-2.282455884178681,"d":"-2.28246"},{"v":0.02246309056134561,"d":"2.25E-02"},25,21,{"v":54.744,"d":"54.74"},{"v":94.76190476190474,"d":"94.76"}]
["FST ","EASIA",{"v":525,"d":"525.0000"},{"v":556,"d":"556.0000"},{"v":200,"d":"200.0000"},{"v":-1.3782946160499283,"d":"-1.37829"},{"v":0.1681133199165158,"d":"0.168113"},25,21,{"v":54.8792,"d":"54.88"},{"v":79.15095238095239,"d":"79.15"}]
["FST ","AME",{"v":521,"d":"521.0000"},{"v":560,"d":"560.0000"},{"v":196,"d":"196.0000"},{"v":-1.4665054714771237,"d":"-1.46651"},{"v":0.14251164228005575,"d":"0.142512"},25,21,{"v":48.6152,"d":"48.62"},{"v":63.358095238095245,"d":"63.36"}]
["FST ","OCE",{"v":536,"d":"536.0000"},{"v":545,"d":"545.0000"},{"v":211,"d":"211.0000"},{"v":-1.1357147636251408,"d":"-1.13571"},{"v":0.25607678648781107,"d":"0.256077"},25,21,{"v":39.9568,"d":"39.96"},{"v":56.32666666666666,"d":"56.33"}]
[]
["iHS","SSAF",{"v":477,"d":"477.0000"},{"v":604,"d":"604.0000"},{"v":152,"d":"152.0000"},{"v":-2.436824881176273,"d":"-2.43682"},{"v":0.01481739316337131,"d":"1.48E-02"},25,21,59.61,85.65]
["iHS","MENA",{"v":502,"d":"502.0000"},{"v":579,"d":"579.0000"},{"v":177,"d":"177.0000"},{"v":-1.8855070347563019,"d":"-1.88551"},{"v":0.059362306236266225,"d":"0.059362"},25,21,63.82,85.12]
["iHS","EUR",{"v":480,"d":"480.0000"},{"v":601,"d":"601.0000"},{"v":155,"d":"155.0000"},{"v":-2.3706667396058765,"d":"-2.37067"},{"v":0.017756619223982858,"d":"1.78E-02"},25,21,61.12,87.83]
["iHS","CSASIA",{"v":506,"d":"506.0000"},{"v":575,"d":"575.0000"},{"v":181,"d":"181.0000"},{"v":-1.7972961793291065,"d":"-1.79730"},{"v":0.07228953956609027,"d":"0.072290"},25,21,61.22,75.36]
["iHS","EASIA",{"v":520,"d":"520.0000"},{"v":561,"d":"561.0000"},{"v":195,"d":"195.0000"},{"v":-1.4885581853339225,"d":"-1.48856"},{"v":0.13660470363573884,"d":"0.136605"},25,21,54.58,65.96]
["iHS","AME",{"v":532,"d":"532.0000"},{"v":549,"d":"549.0000"},{"v":207,"d":"207.0000"},{"v":-1.2239256190523362,"d":"-1.22393"},{"v":0.22098120357279127,"d":"0.220981"},25,21,46.91,63.67]
["iHS","OCE",{"v":544,"d":"544.0000"},{"v":537,"d":"537.0000"},{"v":219,"d":"219.0000"},{"v":-0.95929305277075,"d":"-0.95929"},{"v":0.3374118467771079,"d":"0.337412"},25,21,45.77,56.29]

{"sheet":"Table S8 Chi-test comparison","index":7,"n_rows":13,"n_cols":7,"rows_kept":13,"flags":["formulas_cached_only"]}
["Table S8: comparison of number of events of genetic differentiation (FST) and positive selection (iHS) between the upstream and downstream part of the pathway. A p-value < 0.05  (Chi-square test) means that the number of events is not equally distributed among the two parts of the pathway."]
[]
["FST"]
["subpathway","# genes with \na signal in\nat least one \npopulation","expected","(O-E)^2/E","# of genes"]
["upstream",0,3.804347826086957,3.804347826086957,25]
["downstream",7,3.195652173913044,4.528985507246375,21]
[null,7,null,8.333333333333332,46,"p",0.0038924172848317346]
[]
["iHS"]
["subpathway","# genes with \na signal in\nat least one \npopulation","expected","(O-E)^2/E","# of genes"]
["upstream",4,6.521739130434782,0.9750724637681157,25]
["downstream",8,5.478260869565217,1.1608005521049005,21]
[null,12,null,2.1358730158730164,46,"p",0.14388857642122485]

{"sheet":"Table S9 hypergeometric test","index":8,"n_rows":40,"n_cols":10,"rows_kept":40,"flags":["formulas_cached_only"]}
["Table S9: Hypergeometric test per population. "]
[]
["Test","Continental Group","genes set","# genes in background","# genes in background\n with q<0.05","# genes in \ngenes set","# genes in genes set \n with q<0.05","P (x > X)\n(hypergeometric test)","P (x =< X)\n(hypergeometric test)","X = proportion of successes in background\nx = proportion of successes in gene set"]
["Fst","SSAFR","upstream",6450,321,25,0,{"v":0.721588628238604,"d":"0.722"},{"v":0.27841137176139596,"d":"0.278"}]
["Fst","MENA","upstream",6450,321,25,0,{"v":0.721588628238604,"d":"0.722"},{"v":0.27841137176139596,"d":"0.278"}]
["Fst","EUR","upstream",6450,321,25,0,{"v":0.721588628238604,"d":"0.722"},{"v":0.27841137176139596,"d":"0.278"}]
["Fst","CSASIA","upstream",6450,321,25,0,{"v":0.721588628238604,"d":"0.722"},{"v":0.27841137176139596,"d":"0.278"}]
["Fst","EASIA","upstream",6450,321,25,0,{"v":0.721588628238604,"d":"0.722"},{"v":0.27841137176139596,"d":"0.278"}]
["Fst","AME","upstream",6450,321,25,0,{"v":0.721588628238604,"d":"0.722"},{"v":0.27841137176139596,"d":"0.278"}]
["Fst","OCE","upstream",6450,321,25,0,{"v":0.721588628238604,"d":"0.722"},{"v":0.27841137176139596,"d":"0.278"}]
[]
["Fst","SSAFR","downstream",6450,321,21,1,{"v":0.28118212043323804,"d":"0.281"},{"v":0.7188178795667619,"d":"0.719"}]
["Fst","MENA","downstream",6450,321,21,1,{"v":0.28118212043323804,"d":"0.281"},{"v":0.7188178795667619,"d":"0.719"}]
["Fst","EUR","downstream",6450,321,21,2,{"v":0.0836904248177,"d":"0.084"},{"v":0.9163095751823,"d":"0.916"}]
["Fst","CSASIA","downstream",6450,321,21,3,{"v":0.0183984831209905,"d":"0.018"},{"v":0.9816015168790095,"d":"0.982"}]
["Fst","EASIA","downstream",6450,321,21,1,{"v":0.28118212043323804,"d":"0.281"},{"v":0.7188178795667619,"d":"0.719"}]
["Fst","AME","downstream",6450,321,21,0,{"v":0.6582678267491561,"d":"0.658"},{"v":0.34173217325084393,"d":"0.342"}]
["Fst","OCE","downstream",6450,321,21,0,{"v":0.6582678267491561,"d":"0.658"},{"v":0.34173217325084393,"d":"0.342"}]
[]
["Fst","ALL","upstream",45150,2230,175,0,{"v":0.9986109637999999,"d":"0.999"},{"v":0.0013890362000000822,"d":"0.001"}]
["Fst","ALL","downstream",45150,2230,147,7,{"v":0.44104699301,"d":"0.441"},{"v":0.55895300699,"d":"0.559"}]
[]
["iHS","SSAFR","upstream",6387,318,25,2,{"v":0.12557718829331102,"d":"0.126"},{"v":0.874422811706689,"d":"0.874"}]
["iHS","MENA","upstream",6379,318,25,2,{"v":0.125924445148257,"d":"0.126"},{"v":0.8740755548517429,"d":"0.874"}]
["iHS","EUR","upstream",6369,317,25,2,{"v":0.12548549390667701,"d":"0.125"},{"v":0.874514506093323,"d":"0.875"}]
["iHS","CSASIA","upstream",6378,318,25,1,{"v":0.356464889838061,"d":"0.356"},{"v":0.643535110161939,"d":"0.644"}]
["iHS","EASIA","upstream",6351,317,25,1,{"v":0.356969271441195,"d":"0.357"},{"v":0.643030728558805,"d":"0.643"}]
["iHS","AME","upstream",6261,312,25,0,{"v":0.7220847830810121,"d":"0.722"},{"v":0.2779152169189879,"d":"0.278"}]
["iHS","OCE","upstream",6294,314,25,1,{"v":0.356743079167373,"d":"0.357"},{"v":0.643256920832627,"d":"0.643"}]
[]
["iHS","SSAFR","downstream",6387,318,21,3,{"v":0.0184227165656268,"d":"0.018"},{"v":0.9815772834343732,"d":"0.982"}]
["iHS","MENA","downstream",6379,318,21,2,{"v":0.0840169885983557,"d":"0.084"},{"v":0.9159830114016443,"d":"0.916"}]
["iHS","EUR","downstream",6369,317,21,2,{"v":0.0837057885612489,"d":"0.084"},{"v":0.9162942114387511,"d":"0.916"}]
["iHS","CSASIA","downstream",6378,318,21,0,{"v":0.65896553307397,"d":"0.659"},{"v":0.34103446692603,"d":"0.341"}]
["iHS","EASIA","downstream",6351,317,21,3,{"v":0.0185759524935247,"d":"0.019"},{"v":0.9814240475064753,"d":"0.981"}]
["iHS","AME","downstream",6261,312,21,1,{"v":0.281696760127426,"d":"0.282"},{"v":0.7183032398725739,"d":"0.718"}]
["iHS","OCE","downstream",6294,314,21,0,{"v":0.659199053018382,"d":"0.659"},{"v":0.340800946981618,"d":"0.341"}]
[]
["iHS","ALL","upstream",44419,1843,175,5,{"v":0.73755650828,"d":"0.738"},{"v":0.26244349172000003,"d":"0.262"}]
["iHS","ALL","downstream",44419,1843,147,8,{"v":0.1584929947,"d":"0.158"},{"v":0.8415070053,"d":"0.842"}]

{"sheet":"Table S10 centralities","index":9,"n_rows":65,"n_cols":10,"rows_kept":65,"flags":["formulas_cached_only"]}
["Table S10: Node centralities by gene"]
[]
["gene","subpahway","Betweenness","Centroid","Closeness","Eccentricity","Node.degree","Included","FST_significant","IHS_significant"]
["ALG1","Precursor Biosynthesis",234.666666666668,-32,0.0030303030303030303,0.09090909090909101,3,1,0,0]
["ALG10","Precursor Biosynthesis",589,-12,0.00442477876106195,0.14285714285714302,3,0,"NA","NA"]
["ALG10B","Precursor Biosynthesis",589,-12,0.00442477876106195,0.14285714285714302,3,0,"NA","NA"]
["ALG11","Precursor Biosynthesis",21,-46,0.00245098039215686,0.0769230769230769,3,1,0,0]
["ALG12","Precursor Biosynthesis",439.333333333335,-32,0.0033003300330033,0.1,3,1,0,1]
["ALG13","Precursor Biosynthesis",298.666666666668,-30,0.00335570469798658,0.1,3,0,"NA","NA"]
["ALG14","Precursor Biosynthesis",298.666666666668,-30,0.00335570469798658,0.1,3,1,0,0]
["ALG2","Precursor Biosynthesis",31.1666666666667,-39,0.002710027100271,0.0833333333333333,3,1,0,0]
["ALG3","Precursor Biosynthesis",79,-46,0.00263852242744063,0.0833333333333333,3,1,0,0]
["ALG6","Precursor Biosynthesis",503.333333333335,-32,0.003690036900369,0.11111111111111101,3,1,0,0]
["ALG8","Precursor Biosynthesis",259.166666666668,-21,0.0040485829959514205,0.125,4,1,0,0]
["ALG9","Precursor Biosynthesis",75.3333333333333,-39,0.00292397660818713,0.09090909090909101,3,1,0,0]
["DPAGT1","Precursor Biosynthesis",198,-37,0.00327868852459016,0.1,4,1,0,0]
["RFT1","Precursor Biosynthesis",4,-46,0.00240384615384615,0.0769230769230769,2,1,0,0]
["RPN1","OST Complex",1317.66666666667,0,0.00467289719626168,0.14285714285714302,4,1,0,0]
["RPN2","OST Complex",1317.66666666667,0,0.00467289719626168,0.14285714285714302,4,1,0,0]
["DDOST","OST Complex",1317.66666666667,0,0.00467289719626168,0.14285714285714302,4,1,0,0]
["STT3A","OST Complex",1317.66666666667,0,0.00467289719626168,0.14285714285714302,4,1,0,0]
["STT3B","OST Complex",1317.66666666667,0,0.00467289719626168,0.14285714285714302,4,1,0,0]
["DAD1","OST Complex",1317.66666666667,0,0.00467289719626168,0.14285714285714302,4,1,0,0]
["TUSC3","OST Complex",1317.66666666667,0,0.00467289719626168,0.14285714285714302,4,1,0,0]
["EDEM3","CNX CRT",100,-48,0.00292397660818713,0.09090909090909101,2,1,0,1]
["GANAB","CNX CRT",204,-38,0.00367647058823529,0.11111111111111101,3,1,0,1]
["PRKCSH","CNX CRT",204,-38,0.00367647058823529,0.11111111111111101,3,1,0,0]
["GCS1","CNX CRT",242.5,-38,0.003968253968253971,0.125,2,1,0,1]
["MAN1B1","CNX CRT",219,-38,0.0036101083032490998,0.09090909090909101,2,1,0,0]
["UGCGL1","CNX CRT",196,-39,0.0034013605442176904,0.1,3,1,0,0]
["UGCGL2","CNX CRT",196,-39,0.0034013605,0.1,3,1,0,1]
["FUT8","Branching1",0.8888888888888891,-41,0.00343642611683849,0.0833333333333333,4,1,0,1]
["MAN1A1","Branching1",316,-6,0.00448430493273543,0.11111111111111101,3,1,0,1]
["MAN1A2","Branching1",316,-6,0.00448430493273543,0.11111111111111101,3,1,0,1]
["MAN1C1","Branching1",316,-6,0.00448430493273543,0.11111111111111101,3,1,0,0]
["MAN2A1","Branching1",90.3333333333336,-28,0.00390625,0.09090909090909101,5,1,0,1]
["MAN2A2","Branching1",89.4444444444447,-29,0.00389105058365759,0.09090909090909101,4,1,1,0]
["MGAT1","Branching1",1158.66666666667,-5,0.0043859649122807,0.1,7,1,0,0]
["MGAT2","Branching1",118.775163398693,-30,0.0035714285714285704,0.0833333333333333,14,1,0,1]
["MGAT3","Branching1",816.758169934643,-22,0.004,0.09090909090909101,10,1,1,1]
["MGAT5","Branching1",0.635294117647059,-38,0.0031446540880503103,0.0769230769230769,12,1,0,0]
["B4GALT1","Branching2",44.0547152194213,-31,0.0035587188612099603,0.0833333333333333,13,1,0,0]
["B4GALT2","Branching2",44.0547152194213,-31,0.0035587188612099603,0.0833333333333333,13,1,1,0]
["B4GALT3","Branching2",44.0547152194213,-31,0.0035587188612099603,0.0833333333333333,14,1,0,0]
["MGAT4A","Branching2",1.05751633986928,-37,0.0031545741324921104,0.0769230769230769,13,1,1,0]
["MGAT4B","Branching2",0,-39,0.00313479623824451,0.0769230769230769,11,1,0,0]
["MGAT5B","Branching2",0,-41,0.0031055900621117997,0.0769230769230769,10,1,0,1]
["ST3GAL4","Branching2",1.05751633986928,-37,0.0031545741324921104,0.0769230769230769,12,1,1,0]
["ST6GAL1","Branching2",44.0547152194213,-31,0.0035587188612099603,0.0833333333333333,13,1,0,0]
["ST8SIA2","Branching2",44.0547152194213,-31,0.0035587188612099603,0.0833333333333333,13,1,0,0]
["ST8SIA3","Branching2",44.0547152194213,-31,0.0035587188612099603,0.0833333333333333,13,1,1,1]
["ST8SIA6","Branching2",44.0547152194213,-31,0.0035587188612099603,0.0833333333333333,13,1,1,0]
["ALG5","Substrates",914.83333333333,-13,0.004184100418410041,0.125,5,1,0,0]
["DOLK","Substrates",0,-50,0.0028169014084507,0.09090909090909101,1,1,0,0]
["DOLPP1","Substrates",0,-50,0.0028169014084507,0.09090909090909101,1,1,0,1]
["DPM1","Substrates",256.333333333332,-32,0.0030030030030030004,0.09090909090909101,4,1,1,1]
["DPM2","Substrates",256.3333333333,-32,0.003003003,0.0909090909,4,1,0,1]
["DPM3","Substrates",256.3333333333,-32,0.003003003,0.0909090909,4,1,1,1]
["GMPPA","Substrates",218.1666666667,-32,0.0027624309,0.0833333333,5,1,0,0]
["GMPPB","Substrates",218.1666666667,-32,0.0027624309,0.0833333333,5,0,"NA","NA"]
["PGM3","Substrates",0,-50,0.0031446540880503103,0.1,1,1,0,0]
["PMM1","Substrates",0,-50,0.0024271845,0.0769230769,1,1,1,0]
["PMM2","Substrates",0,-50,0.0024271844660194203,0.0769230769230769,1,1,0,0]
["UAP1","Substrates",618.333333333332,-29,0.0037313432835820903,0.11111111111111101,4,1,0,0]
["MANEA","none",1049.5,-4,0.00458715596330275,0.125,4,0,0,0]