Supp Table 2: GO:BP enrichment of genes with Dichaete binding (DamID 1%FDR) GO Term p-Value Matches organ development [GO:0048513] 1.980161e-84 640 single-organism developmental process [GO:0044767] 1.393900e-75 955 system development [GO:0048731] 3.008669e-66 891 anatomical structure morphogenesis [GO:0009653] 2.455167e-63 711 anatomical structure development [GO:0048856] 5.812913e-60 1046 biological regulation [GO:0065007] 6.748886e-60 1138 regulation of biological process [GO:0050789] 2.923939e-57 1060 regulation of cellular process [GO:0050794] 9.955256e-57 1000 multicellular organismal development [GO:0007275] 4.989977e-56 1001 single-multicellular organism process [GO:0044707] 7.328846e-55 1164 developmental process [GO:0032502] 2.451595e-54 1124 organ morphogenesis [GO:0009887] 4.107377e-54 373 tissue development [GO:0009888] 2.991708e-50 346 multicellular organismal process [GO:0032501] 2.310640e-46 1248 locomotion [GO:0040011] 1.343311e-45 285 single-organism process [GO:0044699] 3.266445e-44 1795 generation of neurons [GO:0048699] 2.918110e-42 374 cell development [GO:0048468] 2.692880e-41 521 single-organism cellular process [GO:0044763] 3.875119e-40 1550 imaginal disc development [GO:0007444] 3.095219e-39 314 post-embryonic organ development [GO:0048569] 1.415821e-37 254 cellular developmental process [GO:0048869] 1.347259e-36 779 cell differentiation [GO:0030154] 1.060664e-35 752 tissue morphogenesis [GO:0048729] 3.343803e-35 193 neuron differentiation [GO:0030182] 5.925910e-35 336 instar larval or pupal morphogenesis [GO:0048707] 7.161368e-35 268 imaginal disc morphogenesis [GO:0007560] 9.073464e-35 239 post-embryonic organ morphogenesis [GO:0048563] 9.073464e-35 239 embryo development [GO:0009790] 9.901565e-34 281 post-embryonic morphogenesis [GO:0009886] 1.360598e-33 269 regulation of RNA metabolic process [GO:0051252] 1.611447e-33 390 regulation of transcription, DNA-dependent [GO:0006355] 2.071649e-33 366 regulation of RNA biosynthetic process [GO:2001141] 2.071649e-33 366 appendage development [GO:0048736] 4.681473e-33 216 metamorphosis [GO:0007552] 6.981209e-33 274 regulation of nucleobase-containing compound metabolic process [GO:0019219] 8.590479e-33 416 cell communication [GO:0007154] 2.389975e-32 635 imaginal disc-derived appendage development [GO:0048737] 2.498918e-32 214 appendage morphogenesis [GO:0035107] 3.314033e-32 213 post-embryonic development [GO:0009791] 7.378085e-32 303 signaling [GO:0023052] 1.444179e-31 620 single organism signaling [GO:0044700] 1.444179e-31 620 imaginal disc-derived appendage morphogenesis [GO:0035114] 1.754688e-31 211 regulation of nitrogen compound metabolic process [GO:0051171] 1.819621e-31 425 sensory organ development [GO:0007423] 3.374294e-31 241 nervous system development [GO:0007399] 9.221429e-31 581 regulation of gene expression [GO:0010468] 1.091623e-30 447 post-embryonic appendage morphogenesis [GO:0035120] 1.630420e-30 207 transcription, DNA-dependent [GO:0006351] 2.106655e-30 377 regulation of macromolecule biosynthetic process [GO:0010556] 2.598964e-30 388 regulation of cellular macromolecule biosynthetic process [GO:2000112] 2.598964e-30 388 RNA biosynthetic process [GO:0032774] 3.974170e-30 377 pattern specification process [GO:0007389] 1.234428e-29 260 regulation of developmental process [GO:0050793] 3.512222e-29 260 instar larval or pupal development [GO:0002165] 4.227143e-29 286 morphogenesis of an epithelium [GO:0002009] 5.845304e-29 174 regulation of cellular biosynthetic process [GO:0031326] 7.545773e-29 397 cell fate commitment [GO:0045165] 8.015041e-29 245 regulation of biosynthetic process [GO:0009889] 1.013446e-28 397 epithelium development [GO:0060429] 1.789066e-28 181 cell morphogenesis [GO:0000902] 2.101241e-28 319 cell morphogenesis involved in differentiation [GO:0000904] 2.712496e-28 233 cellular component morphogenesis [GO:0032989] 8.764710e-27 346 neuron development [GO:0048666] 8.853900e-27 293 eye development [GO:0001654] 2.544780e-26 191 response to stimulus [GO:0050896] 2.549176e-26 872 chemotaxis [GO:0006935] 5.563788e-26 145 regulation of multicellular organismal process [GO:0051239] 4.508552e-25 263 compound eye development [GO:0048749] 5.547742e-25 182 cell morphogenesis involved in neuron differentiation [GO:0048667] 7.387779e-25 214 taxis [GO:0042330] 1.215377e-24 160 muscle structure development [GO:0061061] 1.602702e-24 173 wing disc development [GO:0035220] 1.631292e-24 223 nucleobase-containing compound biosynthetic process [GO:0034654] 2.407668e-24 405 regulation of macromolecule metabolic process [GO:0060255] 3.227696e-24 483 regulation of transcription from RNA polymerase II promoter [GO:0006357] 3.811065e-24 213 cell motility [GO:0048870] 6.632958e-24 148 regionalization [GO:0003002] 7.069315e-24 231 axonogenesis [GO:0007409] 7.094503e-24 166 cell migration [GO:0016477] 8.613873e-24 142 localization of cell [GO:0051674] 1.014337e-23 151 regulation of primary metabolic process [GO:0080090] 1.015751e-23 468 regulation of cellular metabolic process [GO:0031323] 3.719204e-23 480 axon guidance [GO:0007411] 4.785097e-23 136 wing disc morphogenesis [GO:0007472] 5.479706e-23 179 embryonic morphogenesis [GO:0048598] 7.667026e-23 138 imaginal disc-derived wing morphogenesis [GO:0007476] 1.306298e-22 176 response to external stimulus [GO:0009605] 2.381757e-22 216 positive regulation of biological process [GO:0048518] 3.950503e-22 319 cell projection organization [GO:0030030] 1.199400e-21 276 regulation of multicellular organismal development [GO:2000026] 2.383034e-21 185 neuron projection morphogenesis [GO:0048812] 3.462320e-21 239 central nervous system development [GO:0007417] 4.905204e-21 134 neuron projection development [GO:0031175] 4.946909e-21 239 regulation of metabolic process [GO:0019222] 5.709673e-21 526 eye morphogenesis [GO:0048592] 7.617907e-21 154 muscle organ development [GO:0007517] 1.100443e-20 147 signal transduction [GO:0007165] 1.511234e-20 468 negative regulation of biological process [GO:0048519] 1.624504e-20 371 cellular nitrogen compound biosynthetic process [GO:0044271] 2.154390e-20 424 negative regulation of cellular process [GO:0048523] 2.591811e-20 333 positive regulation of cellular process [GO:0048522] 2.765269e-20 296 transcription from RNA polymerase II promoter [GO:0006366] 4.143961e-20 218 compound eye morphogenesis [GO:0001745] 9.080211e-20 147 cellular component movement [GO:0006928] 1.313417e-19 194 regulation of cell differentiation [GO:0045595] 4.933454e-19 160 heterocycle biosynthetic process [GO:0018130] 5.374655e-19 411 neurogenesis [GO:0022008] 1.643159e-18 483 aromatic compound biosynthetic process [GO:0019438] 1.923769e-18 407 cell projection morphogenesis [GO:0048858] 2.879740e-18 247 cell part morphogenesis [GO:0032990] 3.944778e-18 247 cell fate specification [GO:0001708] 1.544626e-17 70 tube development [GO:0035295] 3.694666e-17 100 organic cyclic compound biosynthetic process [GO:1901362] 6.240510e-17 415 positive regulation of gene expression [GO:0010628] 5.813863e-16 134 regulation of anatomical structure morphogenesis [GO:0022603] 2.134540e-15 127 respiratory system development [GO:0060541] 2.669907e-15 119 open tracheal system development [GO:0007424] 2.742153e-15 117 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] 3.797457e-15 106 positive regulation of transcription, DNA-dependent [GO:0045893] 4.820336e-15 130 cellular component organization [GO:0016043] 2.544177e-14 760 regulation of signaling [GO:0023051] 3.177580e-14 239 positive regulation of RNA metabolic process [GO:0051254] 3.388813e-14 133 cell adhesion [GO:0007155] 3.803746e-14 116 regulation of biological quality [GO:0065008] 4.649691e-14 326 response to chemical stimulus [GO:0042221] 6.127173e-14 315 muscle cell differentiation [GO:0042692] 6.365925e-14 110 regulation of cell communication [GO:0010646] 7.254259e-14 239 cardiovascular system development [GO:0072358] 9.104819e-14 65 circulatory system development [GO:0072359] 9.104819e-14 65 digestive tract development [GO:0048565] 1.172334e-13 69 digestive system development [GO:0055123] 1.172334e-13 69 embryo development ending in birth or egg hatching [GO:0009792] 1.986503e-13 105 photoreceptor cell differentiation [GO:0046530] 2.186635e-13 101 heart development [GO:0007507] 2.778588e-13 63 cellular response to stimulus [GO:0051716] 3.018034e-13 545 positive regulation of macromolecule biosynthetic process [GO:0010557] 4.510054e-13 136 positive regulation of nucleobase-containing compound metabolic process [GO:0045935] 4.626439e-13 133 mesoderm development [GO:0007498] 7.162720e-13 68 embryonic development via the syncytial blastoderm [GO:0001700] 7.968257e-13 100 cell fate determination [GO:0001709] 1.116658e-12 87 cell-cell signaling [GO:0007267] 1.277983e-12 225 regulation of cell development [GO:0060284] 1.682877e-12 119 positive regulation of nitrogen compound metabolic process [GO:0051173] 2.636335e-12 141 anatomical structure formation involved in morphogenesis [GO:0048646] 2.708510e-12 219 cellular component organization or biogenesis [GO:0071840] 3.457812e-12 770 biological adhesion [GO:0022610] 3.633707e-12 117 regulation of nervous system development [GO:0051960] 4.337466e-12 102 localization [GO:0051179] 4.529777e-12 637 skeletal muscle organ development [GO:0060538] 4.827800e-12 102 gastrulation [GO:0007369] 5.718248e-12 58 positive regulation of biosynthetic process [GO:0009891] 7.389512e-12 144 positive regulation of cellular biosynthetic process [GO:0031328] 7.389512e-12 144 behavior [GO:0007610] 8.388049e-12 210 gland development [GO:0048732] 9.083580e-12 106 positive regulation of macromolecule metabolic process [GO:0010604] 9.869938e-12 153 regulation of cellular component organization [GO:0051128] 3.238230e-11 201 regulation of response to stimulus [GO:0048583] 4.220012e-11 253 striated muscle cell differentiation [GO:0051146] 8.297918e-11 99 RNA metabolic process [GO:0016070] 1.115503e-10 467 segmentation [GO:0035282] 1.440560e-10 122 embryonic pattern specification [GO:0009880] 1.554197e-10 113 urogenital system development [GO:0001655] 2.531972e-10 53 renal system development [GO:0072001] 2.531972e-10 53 cellular process [GO:0009987] 2.567789e-10 1942 negative regulation of developmental process [GO:0051093] 2.762869e-10 90 regulation of signal transduction [GO:0009966] 2.955063e-10 207 tube morphogenesis [GO:0035239] 3.759617e-10 74 reproductive process [GO:0022414] 4.597265e-10 355 regulation of neurogenesis [GO:0050767] 7.592408e-10 74 negative regulation of RNA metabolic process [GO:0051253] 8.061947e-10 130 growth [GO:0040007] 1.105754e-9 151 muscle tissue development [GO:0060537] 1.437156e-9 89 positive regulation of metabolic process [GO:0009893] 1.718737e-9 161 neuron recognition [GO:0008038] 1.859845e-9 63 negative regulation of transcription from RNA polymerase II promoter [GO:0000122] 1.870025e-9 84 blastoderm segmentation [GO:0007350] 2.094216e-9 104 compound eye photoreceptor cell differentiation [GO:0001751] 2.942173e-9 84 striated muscle tissue development [GO:0014706] 3.142074e-9 88 cell recognition [GO:0008037] 3.818481e-9 63 regulation of cell morphogenesis [GO:0022604] 4.373407e-9 86 negative regulation of biosynthetic process [GO:0009890] 5.128364e-9 143 negative regulation of cellular biosynthetic process [GO:0031327] 5.128364e-9 143 morphogenesis of embryonic epithelium [GO:0016331] 5.971245e-9 70 eye photoreceptor cell differentiation [GO:0001754] 6.281899e-9 85 negative regulation of transcription, DNA-dependent [GO:0045892] 6.933567e-9 125 negative regulation of macromolecule biosynthetic process [GO:0010558] 8.999066e-9 141 negative regulation of cellular macromolecule biosynthetic process [GO:2000113] 8.999066e-9 141 positive regulation of cellular metabolic process [GO:0031325] 9.376022e-9 157 epithelial tube morphogenesis [GO:0060562] 1.633218e-8 61 negative regulation of nucleobase-containing compound metabolic process [GO:0045934] 1.868475e-8 131 system process [GO:0003008] 1.904697e-8 299 negative regulation of nitrogen compound metabolic process [GO:0051172] 1.956625e-8 132 transmission of nerve impulse [GO:0019226] 2.399547e-8 136 multicellular organismal signaling [GO:0035637] 2.399547e-8 136 salivary gland development [GO:0007431] 3.033351e-8 89 exocrine system development [GO:0035272] 3.033351e-8 89 negative regulation of gene expression [GO:0010629] 3.714476e-8 157 single-organism behavior [GO:0044708] 4.309855e-8 162 cell surface receptor signaling pathway [GO:0007166] 4.515099e-8 267 neuron fate commitment [GO:0048663] 7.193679e-8 49 developmental process involved in reproduction [GO:0003006] 7.904342e-8 239 establishment or maintenance of cell polarity [GO:0007163] 8.297386e-8 95 negative regulation of macromolecule metabolic process [GO:0010605] 8.510103e-8 191 synaptic transmission [GO:0007268] 9.996463e-8 132 intracellular signal transduction [GO:0035556] 1.113462e-7 181 establishment of planar polarity [GO:0001736] 1.302542e-7 61 establishment of tissue polarity [GO:0007164] 1.302542e-7 61 brain development [GO:0007420] 1.614666e-7 69 leg disc development [GO:0035218] 2.173756e-7 59 morphogenesis of a polarized epithelium [GO:0001738] 2.951304e-7 65 single organism reproductive process [GO:0044702] 3.108256e-7 285 negative regulation of metabolic process [GO:0009892] 3.123390e-7 194 sexual reproduction [GO:0019953] 3.989357e-7 276 multicellular organismal reproductive process [GO:0048609] 4.037443e-7 301 gamete generation [GO:0007276] 4.852727e-7 272 regulation of neuron differentiation [GO:0045664] 5.322590e-7 58 negative regulation of cellular metabolic process [GO:0031324] 6.972972e-7 162 muscle cell development [GO:0055001] 7.084108e-7 82 renal tubule development [GO:0061326] 7.727310e-7 45 Malpighian tubule development [GO:0072002] 7.727310e-7 45 skeletal muscle tissue development [GO:0007519] 8.843292e-7 80 gliogenesis [GO:0042063] 1.107984e-6 47 establishment of ommatidial planar polarity [GO:0042067] 1.315695e-6 43 cell-cell adhesion [GO:0016337] 1.357929e-6 58 dorsal closure [GO:0007391] 1.456907e-6 58 developmental growth [GO:0048589] 1.463834e-6 101 striated muscle cell development [GO:0055002] 1.476713e-6 81 cell proliferation [GO:0008283] 1.943385e-6 130 sex differentiation [GO:0007548] 3.971015e-6 61 organ formation [GO:0048645] 3.990263e-6 40 formation of anatomical boundary [GO:0048859] 3.991811e-6 40 eye-antennal disc development [GO:0035214] 5.527078e-6 42 neurological system process [GO:0050877] 6.265218e-6 274 digestive tract morphogenesis [GO:0048546] 7.444356e-6 45 head segmentation [GO:0035287] 8.908324e-6 24 formation of primary germ layer [GO:0001704] 9.102314e-6 28 regulation of cell fate specification [GO:0042659] 1.082809e-5 27 transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] 1.290212e-5 77 regulation of cell fate commitment [GO:0010453] 1.484099e-5 28 imaginal disc pattern formation [GO:0007447] 1.615447e-5 60 head development [GO:0060322] 1.616305e-5 25 Ras protein signal transduction [GO:0007265] 1.809806e-5 53 cellular process involved in reproduction in multicellular organism [GO:0022412] 2.070049e-5 214 mesoderm morphogenesis [GO:0048332] 2.417387e-5 26 negative regulation of cell differentiation [GO:0045596] 2.737215e-5 65 synapse organization [GO:0050808] 2.972303e-5 81 actin cytoskeleton organization [GO:0030036] 3.467784e-5 97 neuroblast differentiation [GO:0014016] 4.666905e-5 31 photoreceptor cell fate commitment [GO:0046552] 5.388748e-5 40 actin filament-based process [GO:0030029] 5.423348e-5 100 enzyme linked receptor protein signaling pathway [GO:0007167] 5.535552e-5 100 regulation of growth [GO:0040008] 5.536703e-5 96 reproductive structure development [GO:0048608] 5.856074e-5 51 reproductive system development [GO:0061458] 5.856074e-5 51 leg disc morphogenesis [GO:0007478] 8.352336e-5 48 mesoderm formation [GO:0001707] 8.534705e-5 25 cardiocyte differentiation [GO:0035051] 1.106541e-4 25 regulation of organ morphogenesis [GO:2000027] 1.196002e-4 50 genital disc development [GO:0035215] 1.225576e-4 33 formation of organ boundary [GO:0010160] 1.346559e-4 34 morphogenesis of a branching structure [GO:0001763] 1.391813e-4 39 tissue migration [GO:0090130] 1.407856e-4 33 motor neuron axon guidance [GO:0008045] 1.891518e-4 33 imaginal disc-derived leg morphogenesis [GO:0007480] 2.036658e-4 47 limb morphogenesis [GO:0035108] 2.036658e-4 47 post-embryonic limb morphogenesis [GO:0035127] 2.036658e-4 47 limb development [GO:0060173] 2.036658e-4 47 development of primary sexual characteristics [GO:0045137] 2.195022e-4 46 female gamete generation [GO:0007292] 2.638042e-4 200 hindgut morphogenesis [GO:0007442] 2.639339e-4 39 ovarian follicle cell development [GO:0030707] 3.480296e-4 107 oogenesis [GO:0048477] 3.572044e-4 197 ovarian follicle cell migration [GO:0007297] 3.646769e-4 56 regulation of small GTPase mediated signal transduction [GO:0051056] 3.953258e-4 61 anterior/posterior pattern specification [GO:0009952] 4.217993e-4 83 branching morphogenesis of an epithelial tube [GO:0048754] 4.506396e-4 37 branching involved in open tracheal system development [GO:0060446] 4.506396e-4 37 morphogenesis of a branching epithelium [GO:0061138] 4.506396e-4 37 regulation of Ras protein signal transduction [GO:0046578] 4.776506e-4 57 regulation of cell shape [GO:0008360] 6.665474e-4 60 negative regulation of signaling [GO:0023057] 7.122732e-4 89 muscle fiber development [GO:0048747] 8.659218e-4 65 eye photoreceptor cell fate commitment [GO:0042706] 0.001014 37 eye-antennal disc morphogenesis [GO:0007455] 0.001142 29 ventral cord development [GO:0007419] 0.001161 26 dendrite development [GO:0016358] 0.001190 81 synapse assembly [GO:0007416] 0.001224 58 negative regulation of cell communication [GO:0010648] 0.001329 89 programmed cell death [GO:0012501] 0.001399 113 photoreceptor cell development [GO:0042461] 0.001406 54 midgut development [GO:0007494] 0.001612 26 salivary gland morphogenesis [GO:0007435] 0.001872 68 gland morphogenesis [GO:0022612] 0.001872 68 dendrite morphogenesis [GO:0048813] 0.002201 80 cellular process involved in reproduction [GO:0048610] 0.002235 241 compound eye photoreceptor fate commitment [GO:0001752] 0.002645 36 ameboidal cell migration [GO:0001667] 0.002853 31 negative regulation of signal transduction [GO:0009968] 0.002921 84 reproduction [GO:0000003] 0.007904 393 cell death [GO:0008219] 0.008171 119 gastrulation with mouth forming first [GO:0001703] 0.008778 27 gastrulation involving germ band extension [GO:0010004] 0.008778 27 ectoderm development [GO:0007398] 0.009804 20 death [GO:0016265] 0.009968 120 border follicle cell migration [GO:0007298] 0.014121 50 peripheral nervous system development [GO:0007422] 0.015161 50 glial cell migration [GO:0008347] 0.017922 24 segment specification [GO:0007379] 0.022631 29 regulation of developmental growth [GO:0048638] 0.024084 51 dorsal/ventral pattern formation [GO:0009953] 0.029039 70 wing disc pattern formation [GO:0035222] 0.034570 42 regulation of cell proliferation [GO:0042127] 0.046536 68