LevelGO	Term(Acc)	Term(Name)	#Seq	Score	Parents(Acc)	Parents(Name)
1	GO:0003674	molecular_function	19541	6204.41		
2	GO:0005488	binding	12449	4861.26	GO:0003674	molecular_function
2	GO:0003824	catalytic activity	14100	4179.31	GO:0003674	molecular_function
8	GO:0005524	ATP binding	3508	3508	"GO:0035639, GO:0032559, GO:0032550"	"purine ribonucleoside triphosphate binding, adenyl ribonucleotide binding, purine ribonucleoside binding"
5	GO:0046872	metal ion binding	5384	3435.32	GO:0043169	cation binding
3	GO:0043167	ion binding	9032	2836.17	GO:0005488	binding
3	GO:0097159	organic cyclic compound binding	7395	2669.82	GO:0005488	binding
3	GO:1901363	heterocyclic compound binding	7385	2660.9	GO:0005488	binding
6	GO:0032550	purine ribonucleoside binding	3998	2538	"GO:0032549, GO:0001883"	"ribonucleoside binding, purine nucleoside binding"
5	GO:0035639	purine ribonucleoside triphosphate binding	3848	2378.8	"GO:1901265, GO:0043168"	"nucleoside phosphate binding, anion binding"
7	GO:0032559	adenyl ribonucleotide binding	3727	2302.6	"GO:0030554, GO:0032555"	"adenyl nucleotide binding, purine ribonucleotide binding"
4	GO:0043168	anion binding	5012	2292.57	GO:0043167	ion binding
4	GO:1901265	nucleoside phosphate binding	5529	2113.67	"GO:1901363, GO:0097159"	"heterocyclic compound binding, organic cyclic compound binding"
4	GO:0043169	cation binding	5411	2092.99	GO:0043167	ion binding
3	GO:0016787	hydrolase activity	5953	1913.59	GO:0003824	catalytic activity
3	GO:0005515	protein binding	2531	1911.33	GO:0005488	binding
3	GO:0016740	transferase activity	5723	1885.39	GO:0003824	catalytic activity
4	GO:0000166	nucleotide binding	5528	1853.63	"GO:0036094, GO:1901265"	"small molecule binding, nucleoside phosphate binding"
4	GO:0003676	nucleic acid binding	2640	1840.07	"GO:1901363, GO:0097159"	"heterocyclic compound binding, organic cyclic compound binding"
6	GO:0005509	calcium ion binding	1797	1797	GO:0046872	metal ion binding
6	GO:0032555	purine ribonucleotide binding	4066	1582.2	"GO:0017076, GO:0032553"	"purine nucleotide binding, ribonucleotide binding"
7	GO:0008270	zinc ion binding	1569	1569	GO:0046914	transition metal ion binding
5	GO:0032549	ribonucleoside binding	4005	1529.8	GO:0001882	nucleoside binding
5	GO:0001883	purine nucleoside binding	4001	1525.8	GO:0001882	nucleoside binding
3	GO:0016491	oxidoreductase activity	2679	1455.77	GO:0003824	catalytic activity
6	GO:0030554	adenyl nucleotide binding	3789	1441.32	GO:0017076	purine nucleotide binding
6	GO:0004672	protein kinase activity	2139	1355.66	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
6	GO:0046914	transition metal ion binding	2066	1285.6	GO:0046872	metal ion binding
5	GO:0016301	kinase activity	2711	1268.73	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
3	GO:0036094	small molecule binding	5829	1258.76	GO:0005488	binding
7	GO:0004674	protein serine/threonine kinase activity	1582	1226.34	GO:0004672	protein kinase activity
6	GO:0005216	ion channel activity	1915	1089.08	"GO:0022838, GO:0015075"	"substrate-specific channel activity, ion transmembrane transporter activity"
4	GO:0016772	"transferase activity, transferring phosphorus-containing groups"	3105	1015.99	GO:0016740	transferase activity
5	GO:0017076	purine nucleotide binding	4130	988.18	GO:0000166	nucleotide binding
5	GO:0032553	ribonucleotide binding	4117	985.92	GO:0000166	nucleotide binding
5	GO:0016773	"phosphotransferase activity, alcohol group as acceptor"	2340	947.72	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
4	GO:0001882	nucleoside binding	4010	921.68	"GO:1901363, GO:0036094, GO:0097159"	"heterocyclic compound binding, small molecule binding, organic cyclic compound binding"
7	GO:0017111	nucleoside-triphosphatase activity	1802	840.25	GO:0016462	pyrophosphatase activity
5	GO:0003723	RNA binding	991	797.52	GO:0003676	nucleic acid binding
5	GO:0003677	DNA binding	813	733.4	GO:0003676	nucleic acid binding
5	GO:0015075	ion transmembrane transporter activity	2660	689.89	GO:0022891	substrate-specific transmembrane transporter activity
5	GO:0022838	substrate-specific channel activity	1918	655.85	"GO:0022891, GO:0015267"	"substrate-specific transmembrane transporter activity, channel activity"
7	GO:0005261	cation channel activity	1190	635.68	"GO:0008324, GO:0005216"	"cation transmembrane transporter activity, ion channel activity"
5	GO:0008168	methyltransferase activity	919	632.67	GO:0016741	"transferase activity, transferring one-carbon groups"
4	GO:0016788	"hydrolase activity, acting on ester bonds"	1657	598.94	GO:0016787	hydrolase activity
8	GO:0022843	voltage-gated cation channel activity	921	569.89	"GO:0005261, GO:0005244"	"cation channel activity, voltage-gated ion channel activity"
6	GO:0016462	pyrophosphatase activity	1845	539.3	GO:0016818	"hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"
2	GO:0005215	transporter activity	3229	515.97	GO:0003674	molecular_function
4	GO:0022891	substrate-specific transmembrane transporter activity	2753	500.52	"GO:0022892, GO:0022857"	"substrate-specific transporter activity, transmembrane transporter activity"
4	GO:0008233	peptidase activity	1248	485.33	GO:0016787	hydrolase activity
8	GO:0046873	metal ion transmembrane transporter activity	1434	478.37	GO:0022890	inorganic cation transmembrane transporter activity
9	GO:0005249	voltage-gated potassium channel activity	501	476.56	"GO:0005267, GO:0022843"	"potassium channel activity, voltage-gated cation channel activity"
5	GO:0070011	"peptidase activity, acting on L-amino acid peptides"	1047	473.89	GO:0008233	peptidase activity
3	GO:0022857	transmembrane transporter activity	2978	472.31	GO:0005215	transporter activity
8	GO:0016887	ATPase activity	976	459.05	GO:0017111	nucleoside-triphosphatase activity
8	GO:0005244	voltage-gated ion channel activity	1061	458.49	"GO:0022839, GO:0022832"	"ion gated channel activity, voltage-gated channel activity"
8	GO:0004683	calmodulin-dependent protein kinase activity	469	425.6	GO:0004674	protein serine/threonine kinase activity
8	GO:0005525	GTP binding	425	425	"GO:0032561, GO:0035639, GO:0032550"	"guanyl ribonucleotide binding, purine ribonucleoside triphosphate binding, purine ribonucleoside binding"
9	GO:0003777	microtubule motor activity	435	424.6	GO:0003774	motor activity
5	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"	393	411.59	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"
5	GO:0015267	channel activity	1918	409.77	GO:0022803	passive transmembrane transporter activity
4	GO:0016741	"transferase activity, transferring one-carbon groups"	934	388	GO:0016740	transferase activity
6	GO:0008324	cation transmembrane transporter activity	1818	384.94	GO:0015075	ion transmembrane transporter activity
8	GO:0015077	monovalent inorganic cation transmembrane transporter activity	1254	380.71	GO:0022890	inorganic cation transmembrane transporter activity
4	GO:0008092	cytoskeletal protein binding	700	378.76	GO:0005515	protein binding
7	GO:0005506	iron ion binding	377	372	GO:0046914	transition metal ion binding
3	GO:0022892	substrate-specific transporter activity	2834	367.11	GO:0005215	transporter activity
6	GO:0004175	endopeptidase activity	611	365.24	GO:0070011	"peptidase activity, acting on L-amino acid peptides"
8	GO:0005267	potassium channel activity	582	362.62	"GO:0015079, GO:0005261"	"potassium ion transmembrane transporter activity, cation channel activity"
4	GO:0016705	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"	575	361.4	GO:0016491	oxidoreductase activity
7	GO:0004721	phosphoprotein phosphatase activity	440	360.28	GO:0016791	phosphatase activity
3	GO:0016853	isomerase activity	760	353.59	GO:0003824	catalytic activity
7	GO:0022890	inorganic cation transmembrane transporter activity	1598	348.19	GO:0008324	cation transmembrane transporter activity
7	GO:0022839	ion gated channel activity	1160	347.27	"GO:0022836, GO:0005216"	"gated channel activity, ion channel activity"
6	GO:0016791	phosphatase activity	622	344.82	GO:0042578	phosphoric ester hydrolase activity
4	GO:0016757	"transferase activity, transferring glycosyl groups"	676	338.7	GO:0016740	transferase activity
5	GO:0016706	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"	371	332.04	"GO:0016705, GO:0051213"	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, dioxygenase activity"
5	GO:0016818	"hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"	1850	327.98	GO:0016817	"hydrolase activity, acting on acid anhydrides"
8	GO:0003774	motor activity	516	326.72	GO:0017111	nucleoside-triphosphatase activity
4	GO:0051213	dioxygenase activity	485	322.77	GO:0016491	oxidoreductase activity
3	GO:0048037	cofactor binding	669	321.71	GO:0005488	binding
4	GO:0050662	coenzyme binding	477	321.56	GO:0048037	cofactor binding
3	GO:0016829	lyase activity	660	320.62	GO:0003824	catalytic activity
3	GO:0016874	ligase activity	857	305.41	GO:0003824	catalytic activity
7	GO:0004842	ubiquitin-protein ligase activity	304	302.8	GO:0019787	small conjugating protein ligase activity
9	GO:0042623	"ATPase activity, coupled"	696	298.09	GO:0016887	ATPase activity
7	GO:0032561	guanyl ribonucleotide binding	476	294.4	"GO:0032555, GO:0019001"	"purine ribonucleotide binding, guanyl nucleotide binding"
4	GO:0005543	phospholipid binding	335	290.62	"GO:0008289, GO:0043168"	"lipid binding, anion binding"
4	GO:0016746	"transferase activity, transferring acyl groups"	545	289.61	GO:0016740	transferase activity
4	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"	454	288.53	GO:0016491	oxidoreductase activity
4	GO:0016817	"hydrolase activity, acting on acid anhydrides"	1863	284.99	GO:0016787	hydrolase activity
5	GO:0003779	actin binding	290	277.2	GO:0008092	cytoskeletal protein binding
5	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"	396	276.29	GO:0016746	"transferase activity, transferring acyl groups"
7	GO:0022832	voltage-gated channel activity	1061	275.1	GO:0022836	gated channel activity
3	GO:0004871	signal transducer activity	501	271.47	GO:0060089	molecular transducer activity
5	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"	421	269.93	GO:0016798	"hydrolase activity, acting on glycosyl bonds"
8	GO:0005262	calcium channel activity	362	269.06	"GO:0015085, GO:0005261"	"calcium ion transmembrane transporter activity, cation channel activity"
5	GO:0042578	phosphoric ester hydrolase activity	801	266.96	GO:0016788	"hydrolase activity, acting on ester bonds"
3	GO:0030246	carbohydrate binding	421	260.92	GO:0005488	binding
8	GO:0005272	sodium channel activity	353	254.52	"GO:0015081, GO:0005261"	"sodium ion transmembrane transporter activity, cation channel activity"
9	GO:0015081	sodium ion transmembrane transporter activity	504	246.65	"GO:0046873, GO:0015077"	"metal ion transmembrane transporter activity, monovalent inorganic cation transmembrane transporter activity"
4	GO:0016798	"hydrolase activity, acting on glycosyl bonds"	529	245.88	GO:0016787	hydrolase activity
4	GO:0022803	passive transmembrane transporter activity	1918	245.86	GO:0022857	transmembrane transporter activity
4	GO:0042802	identical protein binding	310	244	GO:0005515	protein binding
5	GO:0052689	carboxylic ester hydrolase activity	245	240.3	GO:0016788	"hydrolase activity, acting on ester bonds"
5	GO:0042626	"ATPase activity, coupled to transmembrane movement of substances"	360	240.25	"GO:0016820, GO:0043492, GO:0015405"	"hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATPase activity, coupled to movement of substances, P-P-bond-hydrolysis-driven transmembrane transporter activity"
9	GO:0015079	potassium ion transmembrane transporter activity	630	238.53	"GO:0046873, GO:0015077"	"metal ion transmembrane transporter activity, monovalent inorganic cation transmembrane transporter activity"
6	GO:0008017	microtubule binding	238	234.4	GO:0015631	tubulin binding
10	GO:0008026	ATP-dependent helicase activity	259	231.72	"GO:0042623, GO:0070035"	"ATPase activity, coupled, purine NTP-dependent helicase activity"
9	GO:0005248	voltage-gated sodium channel activity	236	229.2	"GO:0005272, GO:0022843"	"sodium channel activity, voltage-gated cation channel activity"
9	GO:0015085	calcium ion transmembrane transporter activity	496	228.27	"GO:0046873, GO:0072509"	"metal ion transmembrane transporter activity, divalent inorganic cation transmembrane transporter activity"
2	GO:0009055	electron carrier activity	228	227.4	GO:0003674	molecular_function
5	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	227	227	GO:0016859	cis-trans isomerase activity
6	GO:0000287	magnesium ion binding	222	222	GO:0046872	metal ion binding
8	GO:0004386	helicase activity	392	217.74	GO:0017111	nucleoside-triphosphatase activity
6	GO:0004252	serine-type endopeptidase activity	217	217	"GO:0008236, GO:0004175"	"serine-type peptidase activity, endopeptidase activity"
5	GO:0008236	serine-type peptidase activity	303	216.76	"GO:0017171, GO:0070011"	"serine hydrolase activity, peptidase activity, acting on L-amino acid peptides"
2	GO:0005198	structural molecule activity	319	216.7	GO:0003674	molecular_function
6	GO:0022836	gated channel activity	1160	208.36	GO:0015267	channel activity
6	GO:0008234	cysteine-type peptidase activity	295	205.8	GO:0070011	"peptidase activity, acting on L-amino acid peptides"
3	GO:0008289	lipid binding	384	201.14	GO:0005488	binding
8	GO:0043531	ADP binding	192	192	"GO:0032559, GO:0043168, GO:0032550"	"adenyl ribonucleotide binding, anion binding, purine ribonucleoside binding"
6	GO:0019787	small conjugating protein ligase activity	309	186.48	GO:0016881	acid-amino acid ligase activity
8	GO:0004722	protein serine/threonine phosphatase activity	187	184.6	GO:0004721	phosphoprotein phosphatase activity
4	GO:0019899	enzyme binding	343	180.15	GO:0005515	protein binding
4	GO:0019842	vitamin binding	300	180	GO:0036094	small molecule binding
5	GO:0004518	nuclease activity	352	179.38	GO:0016788	"hydrolase activity, acting on ester bonds"
5	GO:0015631	tubulin binding	269	176.84	GO:0008092	cytoskeletal protein binding
6	GO:0019001	guanyl nucleotide binding	476	176.64	GO:0017076	purine nucleotide binding
5	GO:0031418	L-ascorbic acid binding	176	176	"GO:0048029, GO:0031406, GO:0019842"	"monosaccharide binding, carboxylic acid binding, vitamin binding"
5	GO:0031406	carboxylic acid binding	363	175.07	GO:0043168	anion binding
5	GO:0020037	heme binding	174	174	GO:0046906	tetrapyrrole binding
4	GO:0005516	calmodulin binding	174	174	GO:0005515	protein binding
6	GO:0003950	NAD+ ADP-ribosyltransferase activity	172	172	GO:0016763	"transferase activity, transferring pentosyl groups"
6	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	388	171.82	GO:0008168	methyltransferase activity
5	GO:0050660	flavin adenine dinucleotide binding	176	171.2	"GO:0000166, GO:0050662, GO:0043168"	"nucleotide binding, coenzyme binding, anion binding"
10	GO:0043492	"ATPase activity, coupled to movement of substances"	363	170.55	GO:0042623	"ATPase activity, coupled"
5	GO:0016881	acid-amino acid ligase activity	383	169.49	GO:0016879	"ligase activity, forming carbon-nitrogen bonds"
3	GO:0003735	structural constituent of ribosome	169	169	GO:0005198	structural molecule activity
4	GO:0046983	protein dimerization activity	239	169	GO:0005515	protein binding
9	GO:0005245	voltage-gated calcium channel activity	191	168.72	"GO:0005262, GO:0022843"	"calcium channel activity, voltage-gated cation channel activity"
5	GO:0008603	cAMP-dependent protein kinase regulator activity	166	166	GO:0019887	protein kinase regulator activity
5	GO:0042803	protein homodimerization activity	165	165	"GO:0046983, GO:0042802"	"protein dimerization activity, identical protein binding"
2	GO:0060089	molecular transducer activity	501	162.88	GO:0003674	molecular_function
5	GO:0016702	"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"	167	162.24	"GO:0016701, GO:0051213"	"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, dioxygenase activity"
8	GO:0072509	divalent inorganic cation transmembrane transporter activity	533	160.12	GO:0022890	inorganic cation transmembrane transporter activity
8	GO:0003924	GTPase activity	156	156	GO:0017111	nucleoside-triphosphatase activity
6	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	374	154.11	GO:0015399	primary active transmembrane transporter activity
4	GO:0016879	"ligase activity, forming carbon-nitrogen bonds"	471	153.04	GO:0016874	ligase activity
4	GO:0030170	pyridoxal phosphate binding	153	153	"GO:0048037, GO:0043168"	"cofactor binding, anion binding"
6	GO:0015035	protein disulfide oxidoreductase activity	150	150	GO:0015036	disulfide oxidoreductase activity
4	GO:0016820	"hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"	365	149.15	"GO:0016817, GO:0022857"	"hydrolase activity, acting on acid anhydrides, transmembrane transporter activity"
4	GO:0016849	phosphorus-oxygen lyase activity	180	148.6	GO:0016829	lyase activity
6	GO:0008237	metallopeptidase activity	219	147	GO:0070011	"peptidase activity, acting on L-amino acid peptides"
7	GO:0004713	protein tyrosine kinase activity	166	143.96	GO:0004672	protein kinase activity
5	GO:0016763	"transferase activity, transferring pentosyl groups"	227	142.14	GO:0016757	"transferase activity, transferring glycosyl groups"
5	GO:0016779	nucleotidyltransferase activity	268	141.54	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
9	GO:0070035	purine NTP-dependent helicase activity	259	139.03	GO:0004386	helicase activity
8	GO:0004725	protein tyrosine phosphatase activity	140	137.6	GO:0004721	phosphoprotein phosphatase activity
4	GO:0016859	cis-trans isomerase activity	229	137.4	GO:0016853	isomerase activity
6	GO:0008238	exopeptidase activity	220	136	GO:0070011	"peptidase activity, acting on L-amino acid peptides"
5	GO:0016758	"transferase activity, transferring hexosyl groups"	282	135.59	GO:0016757	"transferase activity, transferring glycosyl groups"
4	GO:0051082	unfolded protein binding	135	135	GO:0005515	protein binding
7	GO:0004197	cysteine-type endopeptidase activity	151	132.6	"GO:0008234, GO:0004175"	"cysteine-type peptidase activity, endopeptidase activity"
4	GO:0017171	serine hydrolase activity	305	132.06	GO:0016787	hydrolase activity
4	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"	266	129.25	GO:0016491	oxidoreductase activity
4	GO:0004497	monooxygenase activity	164	125.84	GO:0016491	oxidoreductase activity
4	GO:0016667	"oxidoreductase activity, acting on a sulfur group of donors"	272	125.62	GO:0016491	oxidoreductase activity
4	GO:0022804	active transmembrane transporter activity	755	122.97	GO:0022857	transmembrane transporter activity
3	GO:0003700	sequence-specific DNA binding transcription factor activity	127	122.7	GO:0001071	nucleic acid binding transcription factor activity
4	GO:0051536	iron-sulfur cluster binding	167	121.2	GO:0051540	metal cluster binding
4	GO:0019887	protein kinase regulator activity	192	119.47	GO:0019207	kinase regulator activity
7	GO:0019829	cation-transporting ATPase activity	148	117.84	"GO:0008324, GO:0042625"	"cation transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions"
6	GO:0032440	2-alkenal reductase [NAD(P)] activity	117	117	GO:0016628	"oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"
7	GO:0004190	aspartic-type endopeptidase activity	118	116.8	"GO:0070001, GO:0004175"	"aspartic-type peptidase activity, endopeptidase activity"
4	GO:0046906	tetrapyrrole binding	191	116.6	"GO:1901363, GO:0097159"	"heterocyclic compound binding, organic cyclic compound binding"
9	GO:0015078	hydrogen ion transmembrane transporter activity	202	116.1	GO:0015077	monovalent inorganic cation transmembrane transporter activity
6	GO:0004519	endonuclease activity	169	113.18	GO:0004518	nuclease activity
3	GO:0038023	signaling receptor activity	231	111.44	"GO:0004871, GO:0004872"	"signal transducer activity, receptor activity"
4	GO:0048029	monosaccharide binding	183	111.4	GO:0030246	carbohydrate binding
8	GO:0018024	histone-lysine N-methyltransferase activity	112	110.6	"GO:0016279, GO:0042054"	"protein-lysine N-methyltransferase activity, histone methyltransferase activity"
5	GO:0016628	"oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"	177	109.56	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
4	GO:0031072	heat shock protein binding	120	108.4	GO:0005515	protein binding
6	GO:0008276	protein methyltransferase activity	202	107.28	GO:0008168	methyltransferase activity
6	GO:0019901	protein kinase binding	116	106.52	GO:0019900	kinase binding
5	GO:0008483	transaminase activity	111	106.04	GO:0016769	"transferase activity, transferring nitrogenous groups"
5	GO:0015291	secondary active transmembrane transporter activity	391	105.01	GO:0022804	active transmembrane transporter activity
4	GO:0016701	"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"	174	104.9	GO:0016491	oxidoreductase activity
6	GO:0043565	sequence-specific DNA binding	115	103.11	GO:0003677	DNA binding
6	GO:0004221	ubiquitin thiolesterase activity	103	103	GO:0016790	thiolester hydrolase activity
4	GO:0016810	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"	202	100.96	GO:0016787	hydrolase activity
2	GO:0030234	enzyme regulator activity	463	99.77	GO:0003674	molecular_function
4	GO:0031177	phosphopantetheine binding	99	99	"GO:0019842, GO:0033218, GO:0072341"	"vitamin binding, amide binding, modified amino acid binding"
6	GO:0015297	antiporter activity	254	98.57	GO:0015291	secondary active transmembrane transporter activity
7	GO:0004222	metalloendopeptidase activity	98	98	"GO:0008237, GO:0004175"	"metallopeptidase activity, endopeptidase activity"
2	GO:0004872	receptor activity	269	97.77	GO:0003674	molecular_function
8	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	111	95.6	GO:0004721	phosphoprotein phosphatase activity
6	GO:0008135	"translation factor activity, nucleic acid binding"	161	95.25	GO:0003723	RNA binding
4	GO:0016651	"oxidoreductase activity, acting on NAD(P)H"	253	94.6	GO:0016491	oxidoreductase activity
5	GO:0015036	disulfide oxidoreductase activity	155	93.4	GO:0016667	"oxidoreductase activity, acting on a sulfur group of donors"
5	GO:0051287	NAD binding	115	93.4	"GO:0000166, GO:0050662"	"nucleotide binding, coenzyme binding"
6	GO:0003729	mRNA binding	112	92.72	GO:0003723	RNA binding
5	GO:0015399	primary active transmembrane transporter activity	374	92.46	GO:0022804	active transmembrane transporter activity
5	GO:0016298	lipase activity	168	92.23	GO:0016788	"hydrolase activity, acting on ester bonds"
6	GO:0004527	exonuclease activity	149	91.32	GO:0004518	nuclease activity
7	GO:0003743	translation initiation factor activity	91	91	GO:0008135	"translation factor activity, nucleic acid binding"
6	GO:0004673	protein histidine kinase activity	125	89.8	"GO:0004672, GO:0016775"	"protein kinase activity, phosphotransferase activity, nitrogenous group as acceptor"
5	GO:0016790	thiolester hydrolase activity	149	89.54	GO:0016788	"hydrolase activity, acting on ester bonds"
6	GO:0016597	amino acid binding	165	89.44	GO:0031406	carboxylic acid binding
7	GO:0016279	protein-lysine N-methyltransferase activity	135	89.36	"GO:0008276, GO:0016278"	"protein methyltransferase activity, lysine N-methyltransferase activity"
6	GO:0008081	phosphoric diester hydrolase activity	174	88.91	GO:0042578	phosphoric ester hydrolase activity
4	GO:0000155	phosphorelay sensor kinase activity	88	88	"GO:0004673, GO:0038023"	"protein histidine kinase activity, signaling receptor activity"
9	GO:0004692	cGMP-dependent protein kinase activity	88	88	GO:0004690	cyclic nucleotide-dependent protein kinase activity
3	GO:0033218	amide binding	171	87.96	GO:0005488	binding
5	GO:0016836	hydro-lyase activity	130	86.76	GO:0016835	carbon-oxygen lyase activity
6	GO:0042625	"ATPase activity, coupled to transmembrane movement of ions"	162	85.14	"GO:0015075, GO:0042626"	"ion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of substances"
8	GO:0015299	solute:hydrogen antiporter activity	120	84.16	"GO:0015298, GO:0015078"	"solute:cation antiporter activity, hydrogen ion transmembrane transporter activity"
6	GO:0004312	fatty acid synthase activity	111	83.32	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
5	GO:0030551	cyclic nucleotide binding	123	82	GO:0000166	nucleotide binding
7	GO:0005351	sugar:hydrogen symporter activity	81	81	"GO:0005402, GO:0015295"	"cation:sugar symporter activity, solute:hydrogen symporter activity"
9	GO:0016905	myosin heavy chain kinase activity	81	81	GO:0004683	calmodulin-dependent protein kinase activity
6	GO:0008170	N-methyltransferase activity	214	80.95	GO:0008168	methyltransferase activity
4	GO:0005102	receptor binding	137	80.75	GO:0005515	protein binding
7	GO:0042054	histone methyltransferase activity	136	80.28	GO:0008276	protein methyltransferase activity
7	GO:0008080	N-acetyltransferase activity	101	78.86	"GO:0016410, GO:0016407"	"N-acyltransferase activity, acetyltransferase activity"
6	GO:0004812	aminoacyl-tRNA ligase activity	107	78.8	GO:0016876	"ligase activity, forming aminoacyl-tRNA and related compounds"
5	GO:0016811	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"	101	78.75	GO:0016810	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"
4	GO:0019904	protein domain specific binding	100	76.96	GO:0005515	protein binding
4	GO:0016835	carbon-oxygen lyase activity	175	76.94	GO:0016829	lyase activity
4	GO:0004016	adenylate cyclase activity	76	76	"GO:0016849, GO:0009975"	"phosphorus-oxygen lyase activity, cyclase activity"
5	GO:0009982	pseudouridine synthase activity	76	76	GO:0016866	intramolecular transferase activity
5	GO:0005083	small GTPase regulator activity	148	75.58	GO:0030695	GTPase regulator activity
3	GO:0019207	kinase regulator activity	197	75.08	GO:0030234	enzyme regulator activity
6	GO:0004620	phospholipase activity	93	74.72	GO:0016298	lipase activity
7	GO:0004177	aminopeptidase activity	75	74.2	GO:0008238	exopeptidase activity
2	GO:0001071	nucleic acid binding transcription factor activity	127	73.62	GO:0003674	molecular_function
3	GO:0051540	metal cluster binding	167	72.72	GO:0005488	binding
10	GO:0005432	calcium:sodium antiporter activity	72	72	"GO:0015368, GO:0015081"	"calcium:cation antiporter activity, sodium ion transmembrane transporter activity"
6	GO:0016174	NAD(P)H oxidase activity	72	72	GO:0050664	"oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"
5	GO:0019900	kinase binding	124	71.91	GO:0019899	enzyme binding
7	GO:0015298	solute:cation antiporter activity	203	71.88	"GO:0008324, GO:0015297"	"cation transmembrane transporter activity, antiporter activity"
8	GO:0015491	cation:cation antiporter activity	154	70.8	GO:0015298	solute:cation antiporter activity
5	GO:0016671	"oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"	71	70.6	GO:0016667	"oxidoreductase activity, acting on a sulfur group of donors"
4	GO:0016866	intramolecular transferase activity	129	70.26	GO:0016853	isomerase activity
6	GO:0070001	aspartic-type peptidase activity	118	70.08	GO:0070011	"peptidase activity, acting on L-amino acid peptides"
6	GO:0003960	NADPH:quinone reductase activity	70	70	GO:0016655	"oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"
3	GO:0009975	cyclase activity	109	69.92	GO:0003824	catalytic activity
5	GO:0008194	UDP-glycosyltransferase activity	161	69.74	GO:0016757	"transferase activity, transferring glycosyl groups"
6	GO:0016408	C-acyltransferase activity	69	69.4	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
9	GO:0015368	calcium:cation antiporter activity	98	68.4	"GO:0015085, GO:0015491"	"calcium ion transmembrane transporter activity, cation:cation antiporter activity"
7	GO:0072341	modified amino acid binding	114	68.4	GO:0016597	amino acid binding
6	GO:0008509	anion transmembrane transporter activity	247	68.35	GO:0015075	ion transmembrane transporter activity
5	GO:0016620	"oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"	96	68.32	GO:0016903	"oxidoreductase activity, acting on the aldehyde or oxo group of donors"
6	GO:0003756	protein disulfide isomerase activity	68	68	"GO:0016864, GO:0016862"	"intramolecular oxidoreductase activity, transposing S-S bonds, intramolecular oxidoreductase activity, interconverting keto- and enol-groups"
6	GO:0004806	triglyceride lipase activity	68	68	"GO:0052689, GO:0016298"	"carboxylic ester hydrolase activity, lipase activity"
8	GO:0004114	"3',5'-cyclic-nucleotide phosphodiesterase activity"	76	67.76	GO:0004112	cyclic-nucleotide phosphodiesterase activity
6	GO:0016407	acetyltransferase activity	140	67.72	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
6	GO:0047879	erythronolide synthase activity	67	67	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
7	GO:0004712	protein serine/threonine/tyrosine kinase activity	71	67	GO:0004672	protein kinase activity
5	GO:0035091	phosphatidylinositol binding	77	66.36	GO:0005543	phospholipid binding
6	GO:0004467	long-chain fatty acid-CoA ligase activity	66	66	GO:0015645	fatty acid ligase activity
6	GO:0031625	ubiquitin protein ligase binding	66	66	GO:0044389	small conjugating protein ligase binding
4	GO:0016765	"transferase activity, transferring alkyl or aryl (other than methyl) groups"	104	65.63	GO:0016740	transferase activity
5	GO:0008146	sulfotransferase activity	87	65.2	GO:0016782	"transferase activity, transferring sulfur-containing groups"
3	GO:0003682	chromatin binding	67	65.16	GO:0005488	binding
6	GO:0030552	cAMP binding	65	65	"GO:0032559, GO:0030551, GO:0043168"	"adenyl ribonucleotide binding, cyclic nucleotide binding, anion binding"
4	GO:0008134	transcription factor binding	78	64.58	GO:0005515	protein binding
8	GO:0004690	cyclic nucleotide-dependent protein kinase activity	106	64.2	GO:0004674	protein serine/threonine kinase activity
6	GO:0004709	MAP kinase kinase kinase activity	64	64	GO:0004702	receptor signaling protein serine/threonine kinase activity
4	GO:0016769	"transferase activity, transferring nitrogenous groups"	112	63.98	GO:0016740	transferase activity
4	GO:0030695	GTPase regulator activity	176	62.75	GO:0060589	nucleoside-triphosphatase regulator activity
3	GO:0008047	enzyme activator activity	161	61.03	GO:0030234	enzyme regulator activity
4	GO:0016830	carbon-carbon lyase activity	134	60.41	GO:0016829	lyase activity
5	GO:0004702	receptor signaling protein serine/threonine kinase activity	100	60	"GO:0004674, GO:0005057"	"protein serine/threonine kinase activity, receptor signaling protein activity"
5	GO:0005528	FK506 binding	60	60	GO:0005527	macrolide binding
7	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	60	60	"GO:0016419, GO:0004312"	"S-malonyltransferase activity, fatty acid synthase activity"
5	GO:0046982	protein heterodimerization activity	60	60	GO:0046983	protein dimerization activity
4	GO:0005096	GTPase activator activity	111	59.58	"GO:0030695, GO:0008047"	"GTPase regulator activity, enzyme activator activity"
7	GO:0004180	carboxypeptidase activity	83	59.4	GO:0008238	exopeptidase activity
5	GO:0051537	"2 iron, 2 sulfur cluster binding"	59	59	GO:0051536	iron-sulfur cluster binding
5	GO:2001070	starch binding	59	59	GO:0030247	polysaccharide binding
4	GO:0000156	phosphorelay response regulator activity	59	59	GO:0004871	signal transducer activity
4	GO:0044325	ion channel binding	59	59	GO:0005515	protein binding
7	GO:0003746	translation elongation factor activity	59	59	GO:0008135	"translation factor activity, nucleic acid binding"
6	GO:0004022	alcohol dehydrogenase (NAD) activity	60	58.8	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
4	GO:0015144	carbohydrate transmembrane transporter activity	114	58.61	"GO:1901476, GO:0022891"	"carbohydrate transporter activity, substrate-specific transmembrane transporter activity"
8	GO:0015276	ligand-gated ion channel activity	121	58.24	"GO:0022839, GO:0022834"	"ion gated channel activity, ligand-gated channel activity"
7	GO:0030145	manganese ion binding	58	58	GO:0046914	transition metal ion binding
6	GO:0003684	damaged DNA binding	58	58	GO:0003677	DNA binding
7	GO:0005507	copper ion binding	57	57	GO:0046914	transition metal ion binding
5	GO:0016655	"oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"	104	56.24	GO:0016651	"oxidoreductase activity, acting on NAD(P)H"
6	GO:0010181	FMN binding	56	56	"GO:0050662, GO:0043168, GO:0032553"	"coenzyme binding, anion binding, ribonucleotide binding"
5	GO:0051539	"4 iron, 4 sulfur cluster binding"	56	56	GO:0051536	iron-sulfur cluster binding
4	GO:0004888	transmembrane signaling receptor activity	121	55.94	GO:0038023	signaling receptor activity
5	GO:0016775	"phosphotransferase activity, nitrogenous group as acceptor"	128	55.68	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
2	GO:0016209	antioxidant activity	96	55.12	GO:0003674	molecular_function
7	GO:0008408	3'-5' exonuclease activity	67	55.08	GO:0004527	exonuclease activity
4	GO:0005319	lipid transporter activity	87	54.4	GO:0022892	substrate-specific transporter activity
6	GO:0070403	NAD+ binding	54	54	"GO:0051287, GO:0043168"	"NAD binding, anion binding"
6	GO:0005097	Rab GTPase activator activity	54	54	GO:0005099	Ras GTPase activator activity
7	GO:0016274	protein-arginine N-methyltransferase activity	34	53.72	"GO:0008276, GO:0016273"	"protein methyltransferase activity, arginine N-methyltransferase activity"
6	GO:0008173	RNA methyltransferase activity	120	53.69	GO:0008168	methyltransferase activity
7	GO:0016278	lysine N-methyltransferase activity	135	53.62	"GO:0008757, GO:0008170"	"S-adenosylmethionine-dependent methyltransferase activity, N-methyltransferase activity"
3	GO:0004601	peroxidase activity	63	53.2	"GO:0016209, GO:0016684"	"antioxidant activity, oxidoreductase activity, acting on peroxide as acceptor"
5	GO:0050661	NADP binding	57	53	"GO:0000166, GO:0050662"	"nucleotide binding, coenzyme binding"
4	GO:0016782	"transferase activity, transferring sulfur-containing groups"	124	52.68	GO:0016740	transferase activity
4	GO:0015238	drug transmembrane transporter activity	70	52.4	"GO:0022857, GO:0090484"	"transmembrane transporter activity, drug transporter activity"
3	GO:0005200	structural constituent of cytoskeleton	52	52	GO:0005198	structural molecule activity
6	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	52	52	GO:0016620	"oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"
7	GO:0015103	inorganic anion transmembrane transporter activity	120	51.68	GO:0008509	anion transmembrane transporter activity
3	GO:0008144	drug binding	94	51.4	GO:0005488	binding
6	GO:0016410	N-acyltransferase activity	107	51.32	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
4	GO:0016903	"oxidoreductase activity, acting on the aldehyde or oxo group of donors"	109	51.07	GO:0016491	oxidoreductase activity
6	GO:0050580	"2,5-didehydrogluconate reductase activity"	51	51	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
7	GO:0003988	acetyl-CoA C-acyltransferase activity	54	50.8	GO:0016408	C-acyltransferase activity
7	GO:0003887	DNA-directed DNA polymerase activity	50	50	GO:0034061	DNA polymerase activity
6	GO:0030553	cGMP binding	50	50	"GO:0032561, GO:0030551, GO:0043168"	"guanyl ribonucleotide binding, cyclic nucleotide binding, anion binding"
9	GO:0005451	monovalent cation:hydrogen antiporter activity	63	49.6	"GO:0015491, GO:0015299"	"cation:cation antiporter activity, solute:hydrogen antiporter activity"
8	GO:0015295	solute:hydrogen symporter activity	81	49.2	GO:0015294	solute:cation symporter activity
6	GO:0005402	cation:sugar symporter activity	82	49.2	"GO:0051119, GO:0015294"	"sugar transmembrane transporter activity, solute:cation symporter activity"
6	GO:0004091	carboxylesterase activity	49	49	GO:0052689	carboxylic ester hydrolase activity
6	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	49	49	GO:0016671	"oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"
5	GO:0016876	"ligase activity, forming aminoacyl-tRNA and related compounds"	109	48.88	GO:0016875	"ligase activity, forming carbon-oxygen bonds"
7	GO:0004112	cyclic-nucleotide phosphodiesterase activity	89	48.46	GO:0008081	phosphoric diester hydrolase activity
10	GO:0008094	DNA-dependent ATPase activity	76	48.32	GO:0042623	"ATPase activity, coupled"
3	GO:0060589	nucleoside-triphosphatase regulator activity	204	47.73	GO:0030234	enzyme regulator activity
5	GO:0015645	fatty acid ligase activity	72	47.6	GO:0016877	"ligase activity, forming carbon-sulfur bonds"
6	GO:0019205	nucleobase-containing compound kinase activity	84	47.34	GO:0016301	kinase activity
5	GO:0016776	"phosphotransferase activity, phosphate group as acceptor"	66	47.24	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
7	GO:0015662	"ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"	72	47.04	GO:0042625	"ATPase activity, coupled to transmembrane movement of ions"
6	GO:0050253	retinyl-palmitate esterase activity	47	47	GO:0052689	carboxylic ester hydrolase activity
12	GO:0005251	delayed rectifier potassium channel activity	47	47	GO:0005249	voltage-gated potassium channel activity
4	GO:0030247	polysaccharide binding	72	46.8	"GO:0001871, GO:0030246"	"pattern binding, carbohydrate binding"
8	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	46	46	GO:0004197	cysteine-type endopeptidase activity
7	GO:0004321	fatty-acyl-CoA synthase activity	46	46	GO:0016408	C-acyltransferase activity
4	GO:0032403	protein complex binding	62	45.96	GO:0005515	protein binding
6	GO:0019843	rRNA binding	47	45.8	GO:0003723	RNA binding
6	GO:0008171	O-methyltransferase activity	81	45.34	GO:0008168	methyltransferase activity
6	GO:0046526	D-xylulose reductase activity	45	45	"GO:0031320, GO:0016616"	"hexitol dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0003939	L-iditol 2-dehydrogenase activity	45	45	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0051393	alpha-actinin binding	56	44.4	GO:0042805	actinin binding
5	GO:0050664	"oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"	73	44.2	GO:0016651	"oxidoreductase activity, acting on NAD(P)H"
4	GO:0008559	xenobiotic-transporting ATPase activity	44	44	"GO:0015238, GO:0042910, GO:0042626"	"drug transmembrane transporter activity, xenobiotic transporter activity, ATPase activity, coupled to transmembrane movement of substances"
6	GO:0018454	acetoacetyl-CoA reductase activity	44	44	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0051119	sugar transmembrane transporter activity	93	43.69	GO:0015144	carbohydrate transmembrane transporter activity
7	GO:0008514	organic anion transmembrane transporter activity	123	43.57	GO:0008509	anion transmembrane transporter activity
8	GO:0005388	calcium-transporting ATPase activity	43	43	"GO:0015085, GO:0019829, GO:0015662"	"calcium ion transmembrane transporter activity, cation-transporting ATPase activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"
6	GO:0008476	protein-tyrosine sulfotransferase activity	43	43	GO:0008146	sulfotransferase activity
6	GO:0050637	lovastatin nonaketide synthase activity	43	43	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
6	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	43	43	"GO:0016616, GO:0004312"	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, fatty acid synthase activity"
6	GO:0043566	structure-specific DNA binding	53	42.65	GO:0003677	DNA binding
4	GO:0042277	peptide binding	67	42.6	GO:0033218	amide binding
7	GO:0003899	DNA-directed RNA polymerase activity	43	42.2	GO:0034062	RNA polymerase activity
4	GO:0016860	intramolecular oxidoreductase activity	113	42.12	GO:0016853	isomerase activity
7	GO:0008235	metalloexopeptidase activity	58	42	"GO:0008238, GO:0008237"	"exopeptidase activity, metallopeptidase activity"
5	GO:0016862	"intramolecular oxidoreductase activity, interconverting keto- and enol-groups"	69	41.4	GO:0016860	intramolecular oxidoreductase activity
5	GO:0016864	"intramolecular oxidoreductase activity, transposing S-S bonds"	68	40.8	GO:0016860	intramolecular oxidoreductase activity
6	GO:0035251	UDP-glucosyltransferase activity	66	40.56	"GO:0046527, GO:0008194"	"glucosyltransferase activity, UDP-glycosyltransferase activity"
12	GO:0008331	high voltage-gated calcium channel activity	40	40	GO:0005245	voltage-gated calcium channel activity
6	GO:0000049	tRNA binding	40	40	GO:0003723	RNA binding
6	GO:1901981	phosphatidylinositol phosphate binding	34	39.6	GO:0035091	phosphatidylinositol binding
5	GO:0044389	small conjugating protein ligase binding	66	39.6	GO:0019899	enzyme binding
4	GO:0016877	"ligase activity, forming carbon-sulfur bonds"	91	39.31	GO:0016874	ligase activity
4	GO:0008565	protein transporter activity	45	39.18	GO:0022892	substrate-specific transporter activity
8	GO:0005227	calcium activated cation channel activity	57	39.08	GO:0005261	cation channel activity
8	GO:0004181	metallocarboxypeptidase activity	39	39	"GO:0004180, GO:0008235"	"carboxypeptidase activity, metalloexopeptidase activity"
6	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	39	39	GO:0016671	"oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"
6	GO:0004012	phospholipid-translocating ATPase activity	39	39	"GO:0005548, GO:0043492"	"phospholipid transporter activity, ATPase activity, coupled to movement of substances"
6	GO:0008374	O-acyltransferase activity	69	38.92	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
6	GO:0015926	glucosidase activity	69	38.48	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
9	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	38	38	"GO:0033549, GO:0008138"	"MAP kinase phosphatase activity, protein tyrosine/serine/threonine phosphatase activity"
8	GO:0004843	ubiquitin-specific protease activity	38	38	GO:0019783	small conjugating protein-specific protease activity
4	GO:0097110	scaffold protein binding	38	38	GO:0005515	protein binding
8	GO:0004402	histone acetyltransferase activity	38	37.68	GO:0008080	N-acetyltransferase activity
9	GO:0003678	DNA helicase activity	51	37.52	GO:0004386	helicase activity
4	GO:0005527	macrolide binding	61	37	"GO:1901363, GO:0008144, GO:0097159"	"heterocyclic compound binding, drug binding, organic cyclic compound binding"
4	GO:0005057	receptor signaling protein activity	101	37	GO:0004871	signal transducer activity
5	GO:0005099	Ras GTPase activator activity	60	36.96	"GO:0005083, GO:0005096"	"small GTPase regulator activity, GTPase activator activity"
6	GO:0015293	symporter activity	114	36.92	GO:0015291	secondary active transmembrane transporter activity
8	GO:0015269	calcium-activated potassium channel activity	40	36.8	"GO:0005267, GO:0005227, GO:0022839"	"potassium channel activity, calcium activated cation channel activity, ion gated channel activity"
7	GO:0015294	solute:cation symporter activity	99	36.53	"GO:0008324, GO:0015293"	"cation transmembrane transporter activity, symporter activity"
9	GO:0005230	extracellular ligand-gated ion channel activity	41	36.26	GO:0015276	ligand-gated ion channel activity
9	GO:0005247	voltage-gated chloride channel activity	36	36	"GO:0005254, GO:0008308"	"chloride channel activity, voltage-gated anion channel activity"
4	GO:0051087	chaperone binding	36	36	GO:0005515	protein binding
7	GO:0016419	S-malonyltransferase activity	60	36	"GO:0016420, GO:0016417"	"malonyltransferase activity, S-acyltransferase activity"
7	GO:0016206	catechol O-methyltransferase activity	36	36	"GO:0008757, GO:0008171"	"S-adenosylmethionine-dependent methyltransferase activity, O-methyltransferase activity"
8	GO:0004715	non-membrane spanning protein tyrosine kinase activity	36	36	GO:0004713	protein tyrosine kinase activity
3	GO:1901505	carbohydrate derivative transporter activity	62	35.58	GO:0005215	transporter activity
3	GO:1901476	carbohydrate transporter activity	114	35.17	GO:0005215	transporter activity
6	GO:0004707	MAP kinase activity	35	35	GO:0004702	receptor signaling protein serine/threonine kinase activity
12	GO:0008332	low voltage-gated calcium channel activity	35	35	GO:0005245	voltage-gated calcium channel activity
7	GO:0022834	ligand-gated channel activity	121	34.94	GO:0022836	gated channel activity
8	GO:0033549	MAP kinase phosphatase activity	50	34.8	GO:0004721	phosphoprotein phosphatase activity
6	GO:0034061	DNA polymerase activity	58	34.56	GO:0016779	nucleotidyltransferase activity
6	GO:0004300	enoyl-CoA hydratase activity	34	34	GO:0016836	hydro-lyase activity
5	GO:0008060	ARF GTPase activator activity	34	34	"GO:0005083, GO:0005096"	"small GTPase regulator activity, GTPase activator activity"
5	GO:0004364	glutathione transferase activity	34	34	GO:0016765	"transferase activity, transferring alkyl or aryl (other than methyl) groups"
5	GO:0016884	"carbon-nitrogen ligase activity, with glutamine as amido-N-donor"	41	33.8	GO:0016879	"ligase activity, forming carbon-nitrogen bonds"
5	GO:0016709	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"	39	33.8	"GO:0016705, GO:0004497"	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, monooxygenase activity"
7	GO:0019201	nucleotide kinase activity	41	33.56	GO:0019205	nucleobase-containing compound kinase activity
8	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	37	33.4	"GO:0043855, GO:0005261, GO:0005217"	"cyclic nucleotide-gated ion channel activity, cation channel activity, intracellular ligand-gated ion channel activity"
7	GO:0016273	arginine N-methyltransferase activity	35	33.23	"GO:0008757, GO:0008170"	"S-adenosylmethionine-dependent methyltransferase activity, N-methyltransferase activity"
8	GO:0005254	chloride channel activity	48	33.2	"GO:0015108, GO:0005253"	"chloride transmembrane transporter activity, anion channel activity"
5	GO:0042805	actinin binding	62	32.64	GO:0008092	cytoskeletal protein binding
3	GO:0090484	drug transporter activity	74	32.6	GO:0005215	transporter activity
5	GO:0005085	guanyl-nucleotide exchange factor activity	59	32.28	GO:0030695	GTPase regulator activity
5	GO:0051117	ATPase binding	32	32	GO:0019899	enzyme binding
7	GO:0008422	beta-glucosidase activity	36	32	GO:0015926	glucosidase activity
7	GO:0003697	single-stranded DNA binding	32	32	GO:0043566	structure-specific DNA binding
10	GO:0015385	sodium:hydrogen antiporter activity	32	32	"GO:0015081, GO:0005451"	"sodium ion transmembrane transporter activity, monovalent cation:hydrogen antiporter activity"
6	GO:0051015	actin filament binding	32	32	GO:0003779	actin binding
4	GO:0005338	nucleotide-sugar transmembrane transporter activity	33	31.96	"GO:0015215, GO:1901505"	"nucleotide transmembrane transporter activity, carbohydrate derivative transporter activity"
4	GO:0016684	"oxidoreductase activity, acting on peroxide as acceptor"	63	31.92	GO:0016491	oxidoreductase activity
5	GO:0043130	ubiquitin binding	41	31.72	GO:0032182	small conjugating protein binding
5	GO:0016831	carboxy-lyase activity	49	31.48	GO:0016830	carbon-carbon lyase activity
5	GO:0003995	acyl-CoA dehydrogenase activity	33	31.4	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
5	GO:0003913	DNA photolyase activity	42	31.4	GO:0016830	carbon-carbon lyase activity
10	GO:0004003	ATP-dependent DNA helicase activity	36	31.2	"GO:0008094, GO:0008026, GO:0003678"	"DNA-dependent ATPase activity, ATP-dependent helicase activity, DNA helicase activity"
7	GO:0003993	acid phosphatase activity	31	31	GO:0016791	phosphatase activity
6	GO:0004348	glucosylceramidase activity	31	31	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
7	GO:0019783	small conjugating protein-specific protease activity	45	30.4	GO:0008234	cysteine-type peptidase activity
5	GO:0008158	hedgehog receptor activity	30	30	GO:0004888	transmembrane signaling receptor activity
4	GO:0008022	protein C-terminus binding	30	30	GO:0005515	protein binding
7	GO:0004767	sphingomyelin phosphodiesterase activity	30	30	"GO:0008081, GO:0004620"	"phosphoric diester hydrolase activity, phospholipase activity"
10	GO:0010348	lithium:hydrogen antiporter activity	30	30	GO:0005451	monovalent cation:hydrogen antiporter activity
5	GO:0016646	"oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"	43	29.64	GO:0016645	"oxidoreductase activity, acting on the CH-NH group of donors"
5	GO:0005548	phospholipid transporter activity	47	29.4	GO:0005319	lipid transporter activity
3	GO:0042910	xenobiotic transporter activity	47	29.4	GO:0005215	transporter activity
4	GO:0016875	"ligase activity, forming carbon-oxygen bonds"	109	29.33	GO:0016874	ligase activity
6	GO:0004597	peptide-aspartate beta-dioxygenase activity	29	29	GO:0016706	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
6	GO:0004176	ATP-dependent peptidase activity	29	29	"GO:0042623, GO:0070011"	"ATPase activity, coupled, peptidase activity, acting on L-amino acid peptides"
7	GO:0051371	muscle alpha-actinin binding	29	29	GO:0051393	alpha-actinin binding
6	GO:0034062	RNA polymerase activity	49	28.92	GO:0016779	nucleotidyltransferase activity
10	GO:0004004	ATP-dependent RNA helicase activity	30	28.8	"GO:0008026, GO:0008186, GO:0003724"	"ATP-dependent helicase activity, RNA-dependent ATPase activity, RNA helicase activity"
7	GO:0022821	potassium ion antiporter activity	41	28.6	"GO:0015079, GO:0015297"	"potassium ion transmembrane transporter activity, antiporter activity"
6	GO:0070569	uridylyltransferase activity	42	28.48	GO:0016779	nucleotidyltransferase activity
9	GO:0005242	inward rectifier potassium channel activity	29	28.2	"GO:0015276, GO:0005249"	"ligand-gated ion channel activity, voltage-gated potassium channel activity"
5	GO:0031320	hexitol dehydrogenase activity	47	28.2	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"
7	GO:0003730	mRNA 3'-UTR binding	29	28.2	GO:0003729	mRNA binding
6	GO:0015215	nucleotide transmembrane transporter activity	47	28.19	"GO:0015605, GO:0015932"	"organophosphate ester transmembrane transporter activity, nucleobase-containing compound transmembrane transporter activity"
6	GO:0046527	glucosyltransferase activity	69	28.14	GO:0016758	"transferase activity, transferring hexosyl groups"
9	GO:0005217	intracellular ligand-gated ion channel activity	49	28.08	GO:0015276	ligand-gated ion channel activity
3	GO:0001871	pattern binding	72	28.08	GO:0005488	binding
7	GO:0008137	NADH dehydrogenase (ubiquinone) activity	28	28	GO:0050136	NADH dehydrogenase (quinone) activity
6	GO:0008375	acetylglucosaminyltransferase activity	36	28	"GO:0016758, GO:0008194"	"transferase activity, transferring hexosyl groups, UDP-glycosyltransferase activity"
7	GO:0004520	endodeoxyribonuclease activity	46	27.92	"GO:0004536, GO:0004519"	"deoxyribonuclease activity, endonuclease activity"
4	GO:0030674	"protein binding, bridging"	31	27.8	"GO:0005515, GO:0060090"	"protein binding, binding, bridging"
5	GO:0016668	"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"	40	27.8	"GO:0016651, GO:0016667"	"oxidoreductase activity, acting on NAD(P)H, oxidoreductase activity, acting on a sulfur group of donors"
7	GO:0017016	Ras GTPase binding	44	27.76	GO:0031267	small GTPase binding
9	GO:0015095	magnesium ion transmembrane transporter activity	28	27.6	"GO:0046873, GO:0072509"	"metal ion transmembrane transporter activity, divalent inorganic cation transmembrane transporter activity"
7	GO:0016893	"endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"	58	27.6	GO:0004519	endonuclease activity
6	GO:0016417	S-acyltransferase activity	73	27.28	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
8	GO:0008273	"calcium, potassium:sodium antiporter activity"	27	27	"GO:0022821, GO:0015368, GO:0015081"	"potassium ion antiporter activity, calcium:cation antiporter activity, sodium ion transmembrane transporter activity"
6	GO:0003727	single-stranded RNA binding	42	26.84	GO:0003723	RNA binding
8	GO:0016888	"endodeoxyribonuclease activity, producing 5'-phosphomonoesters"	32	26.8	"GO:0004520, GO:0016893"	"endodeoxyribonuclease activity, endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
6	GO:0016307	phosphatidylinositol phosphate kinase activity	34	26.6	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
7	GO:0017136	NAD-dependent histone deacetylase activity	22	26.2	"GO:0004407, GO:0034979"	"histone deacetylase activity, NAD-dependent protein deacetylase activity"
3	GO:0008307	structural constituent of muscle	26	26	GO:0005198	structural molecule activity
4	GO:0004383	guanylate cyclase activity	26	26	"GO:0016849, GO:0009975"	"phosphorus-oxygen lyase activity, cyclase activity"
8	GO:0015108	chloride transmembrane transporter activity	55	25.88	GO:0015103	inorganic anion transmembrane transporter activity
4	GO:0016645	"oxidoreductase activity, acting on the CH-NH group of donors"	57	25.7	GO:0016491	oxidoreductase activity
9	GO:0003724	RNA helicase activity	38	25.28	GO:0004386	helicase activity
7	GO:0005089	Rho guanyl-nucleotide exchange factor activity	25	25	GO:0005088	Ras guanyl-nucleotide exchange factor activity
6	GO:0003904	deoxyribodipyrimidine photo-lyase activity	25	25	GO:0003913	DNA photolyase activity
6	GO:0004550	nucleoside diphosphate kinase activity	25	25	"GO:0016776, GO:0019205"	"phosphotransferase activity, phosphate group as acceptor, nucleobase-containing compound kinase activity"
8	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	25	25	GO:0004674	protein serine/threonine kinase activity
3	GO:0019825	oxygen binding	28	24.8	GO:0005488	binding
3	GO:0019239	deaminase activity	38	24.8	GO:0003824	catalytic activity
6	GO:0070008	serine-type exopeptidase activity	33	24.6	"GO:0008238, GO:0008236"	"exopeptidase activity, serine-type peptidase activity"
7	GO:0015171	amino acid transmembrane transporter activity	35	24.57	GO:0046943	carboxylic acid transmembrane transporter activity
6	GO:0004540	ribonuclease activity	69	24.52	GO:0004518	nuclease activity
12	GO:0015271	outward rectifier potassium channel activity	28	24.4	GO:0005249	voltage-gated potassium channel activity
7	GO:0016805	dipeptidase activity	24	24	GO:0008238	exopeptidase activity
5	GO:0008794	arsenate reductase (glutaredoxin) activity	24	24	"GO:0030614, GO:0030611"	"oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor, arsenate reductase activity"
8	GO:0004656	procollagen-proline 4-dioxygenase activity	24	24	"GO:0019798, GO:0031545"	"procollagen-proline dioxygenase activity, peptidyl-proline 4-dioxygenase activity"
9	GO:0004689	phosphorylase kinase activity	24	24	GO:0004683	calmodulin-dependent protein kinase activity
7	GO:0008773	[protein-PII] uridylyltransferase activity	24	24	GO:0070569	uridylyltransferase activity
4	GO:0001671	ATPase activator activity	24	24	"GO:0060590, GO:0008047"	"ATPase regulator activity, enzyme activator activity"
5	GO:0030506	ankyrin binding	24	24	GO:0008092	cytoskeletal protein binding
7	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	24	24	GO:0008376	acetylgalactosaminyltransferase activity
4	GO:0016854	racemase and epimerase activity	73	24	GO:0016853	isomerase activity
9	GO:0046915	transition metal ion transmembrane transporter activity	34	23.55	GO:0046873	metal ion transmembrane transporter activity
7	GO:0031545	peptidyl-proline 4-dioxygenase activity	33	23.4	GO:0031543	peptidyl-proline dioxygenase activity
4	GO:0047485	protein N-terminus binding	27	23.4	GO:0005515	protein binding
6	GO:0046943	carboxylic acid transmembrane transporter activity	56	23.3	"GO:0005342, GO:0008514"	"organic acid transmembrane transporter activity, organic anion transmembrane transporter activity"
6	GO:0004536	deoxyribonuclease activity	74	23.24	GO:0004518	nuclease activity
8	GO:0008469	histone-arginine N-methyltransferase activity	24	23.2	"GO:0016274, GO:0042054"	"protein-arginine N-methyltransferase activity, histone methyltransferase activity"
5	GO:0016814	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"	47	23.18	GO:0016810	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"
7	GO:0004565	beta-galactosidase activity	23	23	GO:0015925	galactosidase activity
7	GO:0032266	phosphatidylinositol-3-phosphate binding	23	23	GO:1901981	phosphatidylinositol phosphate binding
6	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	23	23	"GO:0008094, GO:0061505"	"DNA-dependent ATPase activity, DNA topoisomerase II activity"
5	GO:0030544	Hsp70 protein binding	23	23	GO:0031072	heat shock protein binding
5	GO:0015932	nucleobase-containing compound transmembrane transporter activity	56	22.8	GO:0022891	substrate-specific transmembrane transporter activity
8	GO:0008308	voltage-gated anion channel activity	37	22.6	"GO:0005244, GO:0005253"	"voltage-gated ion channel activity, anion channel activity"
7	GO:0044769	"ATPase activity, coupled to transmembrane movement of ions, rotational mechanism"	26	22.4	GO:0042625	"ATPase activity, coupled to transmembrane movement of ions"
7	GO:0015149	hexose transmembrane transporter activity	24	22.4	GO:0015145	monosaccharide transmembrane transporter activity
6	GO:0036361	"racemase activity, acting on amino acids and derivatives"	39	22.32	GO:0016855	"racemase and epimerase activity, acting on amino acids and derivatives"
7	GO:0047661	amino-acid racemase activity	30	22.2	GO:0036361	"racemase activity, acting on amino acids and derivatives"
5	GO:0016878	acid-thiol ligase activity	31	22.12	GO:0016877	"ligase activity, forming carbon-sulfur bonds"
8	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	22	22	"GO:0004674, GO:0097472"	"protein serine/threonine kinase activity, cyclin-dependent protein kinase activity"
3	GO:0043021	ribonucleoprotein complex binding	30	22	GO:0005488	binding
6	GO:0047849	dextransucrase activity	22	22	GO:0016758	"transferase activity, transferring hexosyl groups"
7	GO:0080025	"phosphatidylinositol-3,5-bisphosphate binding"	22	22	GO:1901981	phosphatidylinositol phosphate binding
6	GO:0005086	ARF guanyl-nucleotide exchange factor activity	22	22	"GO:0005083, GO:0005085"	"small GTPase regulator activity, guanyl-nucleotide exchange factor activity"
6	GO:0004017	adenylate kinase activity	22	22	"GO:0019201, GO:0016776"	"nucleotide kinase activity, phosphotransferase activity, phosphate group as acceptor"
4	GO:0003712	transcription cofactor activity	36	21.64	GO:0000989	transcription factor binding transcription factor activity
8	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	22	21.6	GO:0008106	alcohol dehydrogenase (NADP+) activity
9	GO:0000146	microfilament motor activity	22	21.6	GO:0003774	motor activity
6	GO:0016420	malonyltransferase activity	60	21.6	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
5	GO:0004930	G-protein coupled receptor activity	37	21.16	GO:0004888	transmembrane signaling receptor activity
5	GO:0051879	Hsp90 protein binding	21	21	GO:0031072	heat shock protein binding
9	GO:0008854	exodeoxyribonuclease V activity	21	21	GO:0016895	"exodeoxyribonuclease activity, producing 5'-phosphomonoesters"
4	GO:0016846	carbon-sulfur lyase activity	26	21	GO:0016829	lyase activity
7	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	21	21	GO:0004672	protein kinase activity
5	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	24	20.68	GO:0016835	carbon-oxygen lyase activity
7	GO:0004714	transmembrane receptor protein tyrosine kinase activity	21	20.6	"GO:0004713, GO:0019199"	"protein tyrosine kinase activity, transmembrane receptor protein kinase activity"
8	GO:0004697	protein kinase C activity	23	20.6	GO:0004674	protein serine/threonine kinase activity
7	GO:0005253	anion channel activity	49	20.52	"GO:0008509, GO:0005216"	"anion transmembrane transporter activity, ion channel activity"
6	GO:0004368	glycerol-3-phosphate dehydrogenase activity	22	20.32	GO:0016901	"oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor"
9	GO:0043855	cyclic nucleotide-gated ion channel activity	37	20.04	GO:0015276	ligand-gated ion channel activity
8	GO:0008253	5'-nucleotidase activity	20	20	GO:0008252	nucleotidase activity
7	GO:0033040	sour taste receptor activity	20	20	GO:0008527	taste receptor activity
4	GO:0032182	small conjugating protein binding	43	19.99	GO:0005515	protein binding
8	GO:0004185	serine-type carboxypeptidase activity	20	20	"GO:0004180, GO:0070008"	"carboxypeptidase activity, serine-type exopeptidase activity"
6	GO:0003725	double-stranded RNA binding	20	20	GO:0003723	RNA binding
6	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	20	20	GO:0016763	"transferase activity, transferring pentosyl groups"
6	GO:0047936	glucose 1-dehydrogenase [NAD(P)] activity	20	20	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0016153	urocanate hydratase activity	20	20	GO:0016836	hydro-lyase activity
6	GO:0015166	polyol transmembrane transporter activity	12	19.96	GO:0015665	alcohol transmembrane transporter activity
5	GO:0015211	purine nucleoside transmembrane transporter activity	20	19.96	GO:0005337	nucleoside transmembrane transporter activity
5	GO:0016799	"hydrolase activity, hydrolyzing N-glycosyl compounds"	36	19.87	GO:0016798	"hydrolase activity, acting on glycosyl bonds"
7	GO:0008175	tRNA methyltransferase activity	56	19.85	GO:0008173	RNA methyltransferase activity
5	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	14	19.8	GO:0005338	nucleotide-sugar transmembrane transporter activity
6	GO:0004407	histone deacetylase activity	26	19.72	"GO:0033558, GO:0016811"	"protein deacetylase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"
4	GO:1901682	sulfur compound transmembrane transporter activity	38	19.68	GO:0022857	transmembrane transporter activity
6	GO:0015925	galactosidase activity	33	19.56	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
7	GO:0008242	omega peptidase activity	21	19.4	GO:0008238	exopeptidase activity
6	GO:0050136	NADH dehydrogenase (quinone) activity	31	19.4	"GO:0003954, GO:0016655"	"NADH dehydrogenase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"
6	GO:0070735	protein-glycine ligase activity	22	19.4	GO:0016881	acid-amino acid ligase activity
6	GO:0004033	aldo-keto reductase (NADP) activity	37	19.38	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0015605	organophosphate ester transmembrane transporter activity	51	19.31	"GO:1901677, GO:0008514"	"phosphate transmembrane transporter activity, organic anion transmembrane transporter activity"
8	GO:0016891	"endoribonuclease activity, producing 5'-phosphomonoesters"	26	19.2	"GO:0004521, GO:0016893"	"endoribonuclease activity, endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
4	GO:0032452	histone demethylase activity	16	19.2	GO:0032451	demethylase activity
5	GO:0003713	transcription coactivator activity	24	19.2	GO:0003712	transcription cofactor activity
6	GO:0015145	monosaccharide transmembrane transporter activity	24	19.08	GO:0051119	sugar transmembrane transporter activity
7	GO:0004521	endoribonuclease activity	38	19.04	"GO:0004540, GO:0004519"	"ribonuclease activity, endonuclease activity"
8	GO:0004144	diacylglycerol O-acyltransferase activity	19	19	GO:0016411	acylglycerol O-acyltransferase activity
8	GO:0008536	Ran GTPase binding	19	19	GO:0017016	Ras GTPase binding
9	GO:0004691	cAMP-dependent protein kinase activity	19	19	GO:0004690	cyclic nucleotide-dependent protein kinase activity
7	GO:0008143	poly(A) RNA binding	19	19	"GO:0070717, GO:0003729"	"poly-purine tract binding, mRNA binding"
8	GO:0015386	potassium:hydrogen antiporter activity	19	19	"GO:0022821, GO:0005451"	"potassium ion antiporter activity, monovalent cation:hydrogen antiporter activity"
6	GO:0004835	tubulin-tyrosine ligase activity	19	19	GO:0016881	acid-amino acid ligase activity
8	GO:0035241	protein-arginine omega-N monomethyltransferase activity	19	19	GO:0016274	protein-arginine N-methyltransferase activity
6	GO:0031267	small GTPase binding	46	18.66	GO:0051020	GTPase binding
5	GO:0015116	sulfate transmembrane transporter activity	23	18.6	"GO:1901682, GO:0015103"	"sulfur compound transmembrane transporter activity, inorganic anion transmembrane transporter activity"
5	GO:0016868	"intramolecular transferase activity, phosphotransferases"	29	18.56	GO:0016866	intramolecular transferase activity
7	GO:0004563	beta-N-acetylhexosaminidase activity	20	18.4	GO:0015929	hexosaminidase activity
5	GO:0016901	"oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor"	28	18.39	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"
10	GO:0008186	RNA-dependent ATPase activity	31	18.28	GO:0042623	"ATPase activity, coupled"
4	GO:0003916	DNA topoisomerase activity	39	18.28	GO:0016853	isomerase activity
4	GO:1901677	phosphate transmembrane transporter activity	62	18.19	GO:0022857	transmembrane transporter activity
5	GO:0016717	"oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"	22	18.16	GO:0016705	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"
7	GO:0046524	sucrose-phosphate synthase activity	18	18	GO:0035251	UDP-glucosyltransferase activity
6	GO:0043892	methylglyoxal reductase (NADPH-dependent) activity	18	18	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0002020	protease binding	18	18	GO:0019899	enzyme binding
5	GO:0030165	PDZ domain binding	18	18	GO:0019904	protein domain specific binding
8	GO:0017137	Rab GTPase binding	18	18	GO:0017016	Ras GTPase binding
6	GO:0070566	adenylyltransferase activity	32	17.92	GO:0016779	nucleotidyltransferase activity
4	GO:0015197	peptide transporter activity	37	17.86	GO:0022892	substrate-specific transporter activity
6	GO:0004623	phospholipase A2 activity	19	17.8	"GO:0052689, GO:0004620"	"carboxylic ester hydrolase activity, phospholipase activity"
6	GO:0008378	galactosyltransferase activity	29	17.8	GO:0016758	"transferase activity, transferring hexosyl groups"
6	GO:0034979	NAD-dependent protein deacetylase activity	24	17.72	GO:0033558	protein deacetylase activity
5	GO:0042887	amide transmembrane transporter activity	36	17.6	GO:0022891	substrate-specific transmembrane transporter activity
6	GO:0002161	aminoacyl-tRNA editing activity	18	17.6	GO:0052689	carboxylic ester hydrolase activity
3	GO:0060090	"binding, bridging"	32	17.04	GO:0005488	binding
4	GO:0043022	ribosome binding	17	17	GO:0043021	ribonucleoprotein complex binding
7	GO:0030151	molybdenum ion binding	17	17	GO:0046914	transition metal ion binding
4	GO:0043621	protein self-association	17	17	GO:0005515	protein binding
4	GO:0045502	dynein binding	17	17	GO:0005515	protein binding
5	GO:0019894	kinesin binding	17	17	GO:0008092	cytoskeletal protein binding
8	GO:0046961	"proton-transporting ATPase activity, rotational mechanism"	17	17	"GO:0019829, GO:0015078, GO:0044769"	"cation-transporting ATPase activity, hydrogen ion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions, rotational mechanism"
5	GO:0051059	NF-kappaB binding	17	17	GO:0008134	transcription factor binding
4	GO:0005484	SNAP receptor activity	17	17	GO:0005515	protein binding
9	GO:0004571	"mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"	17	17	GO:0015924	mannosyl-oligosaccharide mannosidase activity
7	GO:0008106	alcohol dehydrogenase (NADP+) activity	26	16.96	GO:0004033	aldo-keto reductase (NADP) activity
5	GO:0016832	aldehyde-lyase activity	25	16.8	GO:0016830	carbon-carbon lyase activity
6	GO:0005088	Ras guanyl-nucleotide exchange factor activity	28	16.8	"GO:0005083, GO:0005085"	"small GTPase regulator activity, guanyl-nucleotide exchange factor activity"
4	GO:0009881	photoreceptor activity	22	16.8	GO:0038023	signaling receptor activity
4	GO:0060590	ATPase regulator activity	28	16.8	GO:0060589	nucleoside-triphosphatase regulator activity
7	GO:0003690	double-stranded DNA binding	22	16.68	GO:0043566	structure-specific DNA binding
5	GO:0033558	protein deacetylase activity	28	16.63	GO:0019213	deacetylase activity
5	GO:0008484	sulfuric ester hydrolase activity	17	16.4	GO:0016788	"hydrolase activity, acting on ester bonds"
6	GO:0031543	peptidyl-proline dioxygenase activity	36	16.4	GO:0016706	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
4	GO:0005346	purine ribonucleotide transmembrane transporter activity	14	16.36	"GO:0015216, GO:1901505"	"purine nucleotide transmembrane transporter activity, carbohydrate derivative transporter activity"
2	GO:0016247	channel regulator activity	25	16.34	GO:0003674	molecular_function
6	GO:0008376	acetylgalactosaminyltransferase activity	26	16.2	"GO:0016758, GO:0008194"	"transferase activity, transferring hexosyl groups, UDP-glycosyltransferase activity"
3	GO:1901681	sulfur compound binding	27	16.2	GO:0005488	binding
5	GO:0016755	"transferase activity, transferring amino-acyl groups"	26	16.2	GO:0016746	"transferase activity, transferring acyl groups"
7	GO:0016411	acylglycerol O-acyltransferase activity	23	16.2	GO:0008374	O-acyltransferase activity
6	GO:0031593	polyubiquitin binding	19	16.2	GO:0043130	ubiquitin binding
5	GO:0004659	prenyltransferase activity	22	16.05	GO:0016765	"transferase activity, transferring alkyl or aryl (other than methyl) groups"
7	GO:0003825	"alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"	16	16	GO:0035251	UDP-glucosyltransferase activity
7	GO:0004298	threonine-type endopeptidase activity	16	16	"GO:0070003, GO:0004175"	"threonine-type peptidase activity, endopeptidase activity"
6	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	16	16	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0033910	"glucan 1,4-alpha-maltotetraohydrolase activity"	16	16	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
8	GO:0005355	glucose transmembrane transporter activity	18	16	GO:0015149	hexose transmembrane transporter activity
6	GO:0008888	glycerol dehydrogenase [NAD+] activity	16	16	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
8	GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	16	16	GO:0016274	protein-arginine N-methyltransferase activity
5	GO:0030507	spectrin binding	16	16	GO:0008092	cytoskeletal protein binding
6	GO:0019200	carbohydrate kinase activity	32	15.96	GO:0016301	kinase activity
3	GO:0032451	demethylase activity	23	15.88	GO:0003824	catalytic activity
7	GO:0016796	"exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"	49	15.86	GO:0004527	exonuclease activity
5	GO:0016780	"phosphotransferase activity, for other substituted phosphate groups"	22	15.84	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
8	GO:0000295	adenine nucleotide transmembrane transporter activity	13	15.76	GO:0015216	purine nucleotide transmembrane transporter activity
5	GO:0016861	"intramolecular oxidoreductase activity, interconverting aldoses and ketoses"	25	15.6	GO:0016860	intramolecular oxidoreductase activity
8	GO:0008519	ammonium transmembrane transporter activity	16	15.6	"GO:0015103, GO:0015077, GO:0015101"	"inorganic anion transmembrane transporter activity, monovalent inorganic cation transmembrane transporter activity, organic cation transmembrane transporter activity"
5	GO:0016857	"racemase and epimerase activity, acting on carbohydrates and derivatives"	22	15.6	GO:0016854	racemase and epimerase activity
6	GO:0031420	alkali metal ion binding	21	15.6	GO:0046872	metal ion binding
6	GO:0019104	DNA N-glycosylase activity	23	15.58	GO:0016799	"hydrolase activity, hydrolyzing N-glycosyl compounds"
4	GO:0016661	"oxidoreductase activity, acting on other nitrogenous compounds as donors"	25	15.44	GO:0016491	oxidoreductase activity
4	GO:0030611	arsenate reductase activity	25	15.4	GO:0016491	oxidoreductase activity
6	GO:0035250	UDP-galactosyltransferase activity	21	15.4	"GO:0008194, GO:0008378"	"UDP-glycosyltransferase activity, galactosyltransferase activity"
4	GO:0005337	nucleoside transmembrane transporter activity	23	15.34	"GO:1901505, GO:0015932"	"carbohydrate derivative transporter activity, nucleobase-containing compound transmembrane transporter activity"
8	GO:0016895	"exodeoxyribonuclease activity, producing 5'-phosphomonoesters"	27	15.24	"GO:0004529, GO:0016796"	"exodeoxyribonuclease activity, exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
7	GO:0019203	carbohydrate phosphatase activity	34	15.1	GO:0016791	phosphatase activity
4	GO:0030976	thiamine pyrophosphate binding	15	15	"GO:0043169, GO:1901363, GO:0019842, GO:0050662, GO:0043168, GO:1901681, GO:0097159"	"cation binding, heterocyclic compound binding, vitamin binding, coenzyme binding, anion binding, sulfur compound binding, organic cyclic compound binding"
8	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	15	15	GO:0031127	"alpha-(1,2)-fucosyltransferase activity"
10	GO:0008574	plus-end-directed microtubule motor activity	15	15	GO:0003777	microtubule motor activity
7	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	15	15	"GO:0008757, GO:0051998"	"S-adenosylmethionine-dependent methyltransferase activity, protein carboxyl O-methyltransferase activity"
5	GO:0017150	tRNA dihydrouridine synthase activity	15	15	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
4	GO:0004000	adenosine deaminase activity	15	15	"GO:0019239, GO:0016814"	"deaminase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"
5	GO:0005544	calcium-dependent phospholipid binding	15	15	GO:0005543	phospholipid binding
6	GO:0036139	peptidyl-histidine dioxygenase activity	15	15	GO:0016706	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
6	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	15	15	"GO:0052689, GO:0004620"	"carboxylic ester hydrolase activity, phospholipase activity"
7	GO:0019798	procollagen-proline dioxygenase activity	25	15	GO:0031543	peptidyl-proline dioxygenase activity
6	GO:0080032	methyl jasmonate esterase activity	15	15	GO:0052689	carboxylic ester hydrolase activity
6	GO:0080030	methyl indole-3-acetate esterase activity	15	15	GO:0052689	carboxylic ester hydrolase activity
6	GO:0036140	peptidyl-asparagine 3-dioxygenase activity	15	15	GO:0016706	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
10	GO:0015369	calcium:hydrogen antiporter activity	15	15	"GO:0051139, GO:0015368"	"metal ion:hydrogen antiporter activity, calcium:cation antiporter activity"
7	GO:0003688	DNA replication origin binding	15	15	GO:0043565	sequence-specific DNA binding
6	GO:0052739	phosphatidylserine 1-acylhydrolase activity	15	15	"GO:0052689, GO:0004620"	"carboxylic ester hydrolase activity, phospholipase activity"
6	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	15	15	"GO:0052689, GO:0004620"	"carboxylic ester hydrolase activity, phospholipase activity"
7	GO:0008252	nucleotidase activity	25	15	GO:0016791	phosphatase activity
6	GO:0050109	morphine 6-dehydrogenase activity	15	15	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0080031	methyl salicylate esterase activity	15	15	GO:0052689	carboxylic ester hydrolase activity
5	GO:0003917	DNA topoisomerase type I activity	15	15	GO:0003916	DNA topoisomerase activity
4	GO:0005496	steroid binding	22	14.88	"GO:0008289, GO:0097159"	"lipid binding, organic cyclic compound binding"
7	GO:0016423	tRNA (guanine) methyltransferase activity	25	14.88	"GO:0008757, GO:0008175"	"S-adenosylmethionine-dependent methyltransferase activity, tRNA methyltransferase activity"
5	GO:0016812	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"	21	14.8	GO:0016810	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"
5	GO:0032934	sterol binding	16	14.8	"GO:0043178, GO:0005496"	"alcohol binding, steroid binding"
5	GO:0019199	transmembrane receptor protein kinase activity	25	14.74	"GO:0004672, GO:0004888"	"protein kinase activity, transmembrane signaling receptor activity"
3	GO:0004857	enzyme inhibitor activity	41	14.65	GO:0030234	enzyme regulator activity
6	GO:0004619	phosphoglycerate mutase activity	17	14.6	GO:0016868	"intramolecular transferase activity, phosphotransferases"
5	GO:0016855	"racemase and epimerase activity, acting on amino acids and derivatives"	40	14.39	GO:0016854	racemase and epimerase activity
5	GO:0030614	"oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor"	24	14.4	GO:0030613	"oxidoreductase activity, acting on phosphorus or arsenic in donors"
5	GO:0016783	sulfurtransferase activity	23	14.2	GO:0016782	"transferase activity, transferring sulfur-containing groups"
8	GO:0050308	sugar-phosphatase activity	23	14.16	GO:0019203	carbohydrate phosphatase activity
7	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity	14	14	GO:0070546	L-phenylalanine aminotransferase activity
6	GO:0047134	protein-disulfide reductase activity	14	14	GO:0016668	"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"
6	GO:0004128	"cytochrome-b5 reductase activity, acting on NAD(P)H"	14	14	GO:0016653	"oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"
7	GO:0048027	mRNA 5'-UTR binding	14	14	GO:0003729	mRNA binding
4	GO:0048306	calcium-dependent protein binding	14	14	GO:0005515	protein binding
5	GO:0000062	fatty-acyl-CoA binding	14	14	"GO:0050662, GO:0043168"	"coenzyme binding, anion binding"
6	GO:0003856	3-dehydroquinate synthase activity	14	14	GO:0016838	"carbon-oxygen lyase activity, acting on phosphates"
6	GO:0015421	oligopeptide-transporting ATPase activity	14	14	"GO:0015440, GO:0035673"	"peptide-transporting ATPase activity, oligopeptide transmembrane transporter activity"
5	GO:0005112	Notch binding	14	14	GO:0005102	receptor binding
4	GO:0005044	scavenger receptor activity	14	14	GO:0038024	cargo receptor activity
7	GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	14	14	"GO:0008170, GO:0016434"	"N-methyltransferase activity, rRNA (cytosine) methyltransferase activity"
6	GO:0015417	polyamine-transporting ATPase activity	14	14	"GO:0015203, GO:0042626"	"polyamine transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of substances"
5	GO:0004129	cytochrome-c oxidase activity	14	14	"GO:0016676, GO:0015078, GO:0015002"	"oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor, hydrogen ion transmembrane transporter activity, heme-copper terminal oxidase activity"
8	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	14	14	GO:0016423	tRNA (guanine) methyltransferase activity
8	GO:0004127	cytidylate kinase activity	14	14	GO:0019201	nucleotide kinase activity
5	GO:0005342	organic acid transmembrane transporter activity	56	13.98	GO:0022891	substrate-specific transmembrane transporter activity
4	GO:0019213	deacetylase activity	34	13.98	GO:0016787	hydrolase activity
5	GO:0061505	DNA topoisomerase II activity	23	13.8	GO:0003916	DNA topoisomerase activity
6	GO:0008172	S-methyltransferase activity	17	13.8	GO:0008168	methyltransferase activity
7	GO:0015101	organic cation transmembrane transporter activity	23	13.72	GO:0008324	cation transmembrane transporter activity
3	GO:0000989	transcription factor binding transcription factor activity	38	13.7	GO:0000988	protein binding transcription factor activity
5	GO:0003954	NADH dehydrogenase activity	33	13.64	GO:0016651	"oxidoreductase activity, acting on NAD(P)H"
7	GO:0016906	sterol 3-beta-glucosyltransferase activity	14	13.6	GO:0035251	UDP-glucosyltransferase activity
5	GO:0004866	endopeptidase inhibitor activity	18	13.6	"GO:0030414, GO:0061135"	"peptidase inhibitor activity, endopeptidase regulator activity"
6	GO:0046923	ER retention sequence binding	17	13.4	GO:0005048	signal sequence binding
7	GO:0000217	DNA secondary structure binding	16	13.36	GO:0043566	structure-specific DNA binding
7	GO:0097472	cyclin-dependent protein kinase activity	22	13.2	GO:0004672	protein kinase activity
6	GO:0008417	fucosyltransferase activity	24	13.2	GO:0016758	"transferase activity, transferring hexosyl groups"
4	GO:0015562	efflux transmembrane transporter activity	14	13.2	GO:0022857	transmembrane transporter activity
6	GO:0016972	thiol oxidase activity	14	13.2	GO:0016670	"oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"
5	GO:0016833	oxo-acid-lyase activity	18	13.2	GO:0016830	carbon-carbon lyase activity
7	GO:0031402	sodium ion binding	13	13	GO:0031420	alkali metal ion binding
6	GO:0003796	lysozyme activity	13	13	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
8	GO:0008198	ferrous iron binding	13	13	GO:0005506	iron ion binding
8	GO:0019003	GDP binding	13	13	"GO:0032561, GO:0043168, GO:0032550"	"guanyl ribonucleotide binding, anion binding, purine ribonucleoside binding"
5	GO:0016653	"oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"	21	13	GO:0016651	"oxidoreductase activity, acting on NAD(P)H"
8	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	13	13	GO:0016427	tRNA (cytosine) methyltransferase activity
7	GO:0008440	"inositol-1,4,5-trisphosphate 3-kinase activity"	13	13	GO:0051766	inositol trisphosphate kinase activity
10	GO:0008568	microtubule-severing ATPase activity	13	13	GO:0042623	"ATPase activity, coupled"
7	GO:0004652	polynucleotide adenylyltransferase activity	13	13	GO:0070566	adenylyltransferase activity
7	GO:0030955	potassium ion binding	13	13	GO:0031420	alkali metal ion binding
5	GO:0071532	ankyrin repeat binding	13	13	GO:0019904	protein domain specific binding
5	GO:0050998	nitric-oxide synthase binding	13	13	GO:0019899	enzyme binding
8	GO:0008663	"2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"	13	13	GO:0004112	cyclic-nucleotide phosphodiesterase activity
6	GO:0004617	phosphoglycerate dehydrogenase activity	13	13	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
7	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	13	13	GO:0016791	phosphatase activity
5	GO:0051864	histone demethylase activity (H3-K36 specific)	13	13	"GO:0032452, GO:0016706"	"histone demethylase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
5	GO:0031432	titin binding	13	13	GO:0008092	cytoskeletal protein binding
6	GO:0016630	protochlorophyllide reductase activity	13	13	GO:0016628	"oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"
7	GO:0008649	rRNA methyltransferase activity	33	12.9	"GO:0008757, GO:0008173"	"S-adenosylmethionine-dependent methyltransferase activity, RNA methyltransferase activity"
6	GO:0015929	hexosaminidase activity	23	12.84	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
4	GO:0019888	protein phosphatase regulator activity	20	12.76	GO:0019208	phosphatase regulator activity
6	GO:0019903	protein phosphatase binding	15	12.6	GO:0019902	phosphatase binding
5	GO:0015665	alcohol transmembrane transporter activity	13	12.58	"GO:1901618, GO:0022891"	"organic hydroxy compound transmembrane transporter activity, substrate-specific transmembrane transporter activity"
7	GO:0044212	transcription regulatory region DNA binding	17	12.35	GO:0000975	regulatory region DNA binding
5	GO:0016899	"oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"	16	12.24	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"
5	GO:0051020	GTPase binding	47	12.19	GO:0019899	enzyme binding
6	GO:0017057	6-phosphogluconolactonase activity	12	12	GO:0052689	carboxylic ester hydrolase activity
8	GO:0008266	poly(U) RNA binding	12	12	GO:0008187	poly-pyrimidine tract binding
8	GO:0005354	galactose transmembrane transporter activity	12	12	GO:0015149	hexose transmembrane transporter activity
9	GO:0004331	"fructose-2,6-bisphosphate 2-phosphatase activity"	12	12	GO:0050308	sugar-phosphatase activity
7	GO:0008967	phosphoglycolate phosphatase activity	12	12	GO:0016791	phosphatase activity
6	GO:0035673	oligopeptide transmembrane transporter activity	20	12	"GO:0015198, GO:0042887"	"oligopeptide transporter activity, amide transmembrane transporter activity"
7	GO:0008527	taste receptor activity	20	12	GO:0004930	G-protein coupled receptor activity
6	GO:0071949	FAD binding	12	12	GO:0050660	flavin adenine dinucleotide binding
8	GO:0046933	"proton-transporting ATP synthase activity, rotational mechanism"	12	12	"GO:0019829, GO:0015078, GO:0044769"	"cation-transporting ATPase activity, hydrogen ion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions, rotational mechanism"
6	GO:0018580	nitronate monooxygenase activity	12	12	GO:0016703	"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)"
7	GO:0003873	6-phosphofructo-2-kinase activity	12	12	GO:0008443	phosphofructokinase activity
7	GO:0043225	anion transmembrane-transporting ATPase activity	20	12	"GO:0008509, GO:0042625"	"anion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions"
4	GO:0016744	"transferase activity, transferring aldehyde or ketonic groups"	16	12	GO:0016740	transferase activity
9	GO:0004523	ribonuclease H activity	12	12	GO:0016891	"endoribonuclease activity, producing 5'-phosphomonoesters"
6	GO:0031685	adenosine receptor binding	12	12	GO:0001664	G-protein coupled receptor binding
5	GO:0042826	histone deacetylase binding	12	12	GO:0019899	enzyme binding
5	GO:0070628	proteasome binding	12	12	GO:0032403	protein complex binding
5	GO:0051007	squalene-hopene cyclase activity	12	12	"GO:0016866, GO:0034072"	"intramolecular transferase activity, squalene cyclase activity"
5	GO:0048156	tau protein binding	12	12	GO:0008092	cytoskeletal protein binding
7	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	12	12	GO:0016307	phosphatidylinositol phosphate kinase activity
12	GO:0086006	voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential	14	12	GO:0005248	voltage-gated sodium channel activity
7	GO:0050897	cobalt ion binding	12	12	GO:0046914	transition metal ion binding
6	GO:0004792	thiosulfate sulfurtransferase activity	12	12	GO:0016783	sulfurtransferase activity
6	GO:0008667	"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"	12	12	GO:0016628	"oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"
8	GO:0000175	3'-5'-exoribonuclease activity	16	12	"GO:0016896, GO:0008408"	"exoribonuclease activity, producing 5'-phosphomonoesters, 3'-5' exonuclease activity"
6	GO:0004148	dihydrolipoyl dehydrogenase activity	12	12	GO:0016668	"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"
8	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	12	12	GO:0016274	protein-arginine N-methyltransferase activity
7	GO:0004339	"glucan 1,4-alpha-glucosidase activity"	12	12	GO:0015926	glucosidase activity
5	GO:0001664	G-protein coupled receptor binding	21	11.96	GO:0005102	receptor binding
7	GO:0004558	alpha-glucosidase activity	15	11.8	GO:0015926	glucosidase activity
8	GO:0003747	translation release factor activity	15	11.8	GO:0008079	translation termination factor activity
6	GO:0004084	branched-chain-amino-acid transaminase activity	7	11.8	GO:0008483	transaminase activity
7	GO:0004559	alpha-mannosidase activity	23	11.72	GO:0015923	mannosidase activity
4	GO:0016638	"oxidoreductase activity, acting on the CH-NH2 group of donors"	28	11.68	GO:0016491	oxidoreductase activity
6	GO:0004568	chitinase activity	12	11.6	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
9	GO:0047555	"3',5'-cyclic-GMP phosphodiesterase activity"	12	11.6	GO:0004114	"3',5'-cyclic-nucleotide phosphodiesterase activity"
5	GO:0016634	"oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"	20	11.52	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
4	GO:0051219	phosphoprotein binding	14	11.44	GO:0005515	protein binding
7	GO:0070717	poly-purine tract binding	19	11.4	GO:0003727	single-stranded RNA binding
5	GO:0019905	syntaxin binding	12	11.4	GO:0000149	SNARE binding
6	GO:0008443	phosphofructokinase activity	16	11.4	"GO:0016773, GO:0019200"	"phosphotransferase activity, alcohol group as acceptor, carbohydrate kinase activity"
4	GO:0043178	alcohol binding	20	11.28	GO:0036094	small molecule binding
3	GO:0005246	calcium channel regulator activity	12	11.2	GO:0016247	channel regulator activity
8	GO:0016896	"exoribonuclease activity, producing 5'-phosphomonoesters"	22	11.2	"GO:0004532, GO:0016796"	"exoribonuclease activity, exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
3	GO:0097367	carbohydrate derivative binding	23	11.16	GO:0005488	binding
2	GO:0000988	protein binding transcription factor activity	46	11.12	GO:0003674	molecular_function
7	GO:0015216	purine nucleotide transmembrane transporter activity	15	11.02	GO:0015215	nucleotide transmembrane transporter activity
8	GO:0004338	"glucan exo-1,3-beta-glucosidase activity"	11	11	GO:0008422	beta-glucosidase activity
6	GO:0015923	mannosidase activity	28	10.99	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
6	GO:0004089	carbonate dehydratase activity	11	11	GO:0016836	hydro-lyase activity
6	GO:0048487	beta-tubulin binding	11	11	GO:0015631	tubulin binding
10	GO:0008569	minus-end-directed microtubule motor activity	11	11	GO:0003777	microtubule motor activity
3	GO:0004791	thioredoxin-disulfide reductase activity	11	11	"GO:0016668, GO:0016209"	"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor, antioxidant activity"
6	GO:0033925	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	11	11	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
8	GO:0004805	trehalose-phosphatase activity	11	11	GO:0019203	carbohydrate phosphatase activity
5	GO:0008812	choline dehydrogenase activity	11	11	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"
5	GO:0005315	inorganic phosphate transmembrane transporter activity	11	11	"GO:1901677, GO:0015291"	"phosphate transmembrane transporter activity, secondary active transmembrane transporter activity"
8	GO:0004849	uridine kinase activity	11	11	GO:0019206	nucleoside kinase activity
6	GO:0004140	dephospho-CoA kinase activity	11	11	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
9	GO:0005222	intracellular cAMP activated cation channel activity	11	11	GO:0005221	intracellular cyclic nucleotide activated cation channel activity
4	GO:0050839	cell adhesion molecule binding	13	11	GO:0005515	protein binding
8	GO:0047462	phenylalanine racemase (ATP-hydrolyzing) activity	11	11	GO:0047661	amino-acid racemase activity
4	GO:0016018	cyclosporin A binding	11	11	"GO:0042277, GO:0008144"	"peptide binding, drug binding"
3	GO:0004784	superoxide dismutase activity	11	11	"GO:0016721, GO:0016209"	"oxidoreductase activity, acting on superoxide radicals as acceptor, antioxidant activity"
6	GO:0004090	carbonyl reductase (NADPH) activity	11	11	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0009916	alternative oxidase activity	11	11	GO:0016682	"oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"
7	GO:0016151	nickel cation binding	11	11	GO:0046914	transition metal ion binding
6	GO:0008800	beta-lactamase activity	11	11	GO:0016812	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"
8	GO:0030983	mismatched DNA binding	11	10.8	GO:0003690	double-stranded DNA binding
7	GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	9	10.8	GO:0070569	uridylyltransferase activity
7	GO:0035258	steroid hormone receptor binding	18	10.8	GO:0035257	nuclear hormone receptor binding
5	GO:0016838	"carbon-oxygen lyase activity, acting on phosphates"	18	10.8	GO:0016835	carbon-oxygen lyase activity
3	GO:0051184	cofactor transporter activity	20	10.72	GO:0005215	transporter activity
7	GO:0052866	phosphatidylinositol phosphate phosphatase activity	19	10.68	GO:0016791	phosphatase activity
6	GO:0004029	aldehyde dehydrogenase (NAD) activity	11	10.6	GO:0016620	"oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"
5	GO:0005048	signal sequence binding	21	10.6	GO:0042277	peptide binding
3	GO:0008641	small protein activating enzyme activity	12	10.6	GO:0003824	catalytic activity
5	GO:0046857	"oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"	15	10.4	GO:0016661	"oxidoreductase activity, acting on other nitrogenous compounds as donors"
5	GO:0015198	oligopeptide transporter activity	23	10.4	GO:0015197	peptide transporter activity
5	GO:0015440	peptide-transporting ATPase activity	16	10.4	"GO:0042887, GO:0042626, GO:0015197"	"amide transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of substances, peptide transporter activity"
6	GO:0016289	CoA hydrolase activity	17	10.36	GO:0016790	thiolester hydrolase activity
5	GO:0016405	CoA-ligase activity	17	10.32	GO:0016877	"ligase activity, forming carbon-sulfur bonds"
7	GO:0019206	nucleoside kinase activity	18	10.32	GO:0019205	nucleobase-containing compound kinase activity
6	GO:0004104	cholinesterase activity	13	10.2	GO:0052689	carboxylic ester hydrolase activity
5	GO:0046912	"transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"	16	10.2	GO:0016746	"transferase activity, transferring acyl groups"
5	GO:0016863	"intramolecular oxidoreductase activity, transposing C=C bonds"	17	10.2	GO:0016860	intramolecular oxidoreductase activity
8	GO:0015179	L-amino acid transmembrane transporter activity	9	10.2	GO:0015171	amino acid transmembrane transporter activity
8	GO:0015924	mannosyl-oligosaccharide mannosidase activity	17	10.2	GO:0004559	alpha-mannosidase activity
6	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	7	10.2	"GO:0004312, GO:0016790"	"fatty acid synthase activity, thiolester hydrolase activity"
5	GO:0016670	"oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"	17	10.12	GO:0016667	"oxidoreductase activity, acting on a sulfur group of donors"
6	GO:0004143	diacylglycerol kinase activity	10	10	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
8	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	10	10	"GO:0032129, GO:0017136"	"histone deacetylase activity (H3-K9 specific), NAD-dependent histone deacetylase activity"
6	GO:0050641	6-methylsalicylic acid synthase activity	10	10	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
4	GO:0046332	SMAD binding	11	10	GO:0005515	protein binding
5	GO:0031996	thioesterase binding	10	10	GO:0019899	enzyme binding
9	GO:0004115	"3',5'-cyclic-AMP phosphodiesterase activity"	10	10	GO:0004114	"3',5'-cyclic-nucleotide phosphodiesterase activity"
4	GO:0009927	histidine phosphotransfer kinase activity	10	10	"GO:0016301, GO:0004871"	"kinase activity, signal transducer activity"
5	GO:0017134	fibroblast growth factor binding	10	10	GO:0019838	growth factor binding
6	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	10	10	GO:0008483	transaminase activity
9	GO:0004535	poly(A)-specific ribonuclease activity	10	10	GO:0000175	3'-5'-exoribonuclease activity
7	GO:0070736	"protein-glycine ligase activity, initiating"	10	10	GO:0070735	protein-glycine ligase activity
6	GO:0008474	palmitoyl-(protein) hydrolase activity	10	10	GO:0016790	thiolester hydrolase activity
7	GO:0070740	tubulin-glutamic acid ligase activity	10	10	GO:0070739	protein-glutamic acid ligase activity
7	GO:0004427	inorganic diphosphatase activity	10	10	GO:0016462	pyrophosphatase activity
4	GO:0043546	molybdopterin cofactor binding	10	10	"GO:1901363, GO:0050662, GO:0097159"	"heterocyclic compound binding, coenzyme binding, organic cyclic compound binding"
7	GO:0008187	poly-pyrimidine tract binding	13	10	GO:0003727	single-stranded RNA binding
6	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	10	10	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
8	GO:0004414	homoserine O-acetyltransferase activity	10	10	GO:0016413	O-acetyltransferase activity
5	GO:0005178	integrin binding	10	10	"GO:0032403, GO:0005102"	"protein complex binding, receptor binding"
7	GO:0016262	protein N-acetylglucosaminyltransferase activity	10	10	GO:0008375	acetylglucosaminyltransferase activity
7	GO:0016413	O-acetyltransferase activity	16	10	"GO:0008374, GO:0016407"	"O-acyltransferase activity, acetyltransferase activity"
6	GO:0004576	oligosaccharyl transferase activity	14	10	GO:0016758	"transferase activity, transferring hexosyl groups"
9	GO:0042132	"fructose 1,6-bisphosphate 1-phosphatase activity"	10	10	GO:0050308	sugar-phosphatase activity
6	GO:0004332	fructose-bisphosphate aldolase activity	10	10	GO:0016832	aldehyde-lyase activity
8	GO:0004708	MAP kinase kinase activity	10	10	GO:0004712	protein serine/threonine/tyrosine kinase activity
7	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	10	10	GO:0004576	oligosaccharyl transferase activity
5	GO:0015168	glycerol transmembrane transporter activity	10	10	"GO:0015144, GO:0015166"	"carbohydrate transmembrane transporter activity, polyol transmembrane transporter activity"
5	GO:0009882	blue light photoreceptor activity	10	10	GO:0009881	photoreceptor activity
11	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	10	10	"GO:0043138, GO:0004003"	"3'-5' DNA helicase activity, ATP-dependent DNA helicase activity"
8	GO:0036310	annealing helicase activity	10	10	GO:0017111	nucleoside-triphosphatase activity
4	GO:0042393	histone binding	10	10	GO:0005515	protein binding
7	GO:0070737	"protein-glycine ligase activity, elongating"	10	10	GO:0070735	protein-glycine ligase activity
4	GO:0004602	glutathione peroxidase activity	10	10	GO:0004601	peroxidase activity
6	GO:0008831	dTDP-4-dehydrorhamnose reductase activity	10	10	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0001085	RNA polymerase II transcription factor binding	11	9.96	GO:0008134	transcription factor binding
4	GO:0016229	steroid dehydrogenase activity	21	9.84	GO:0016491	oxidoreductase activity
7	GO:0004308	exo-alpha-sialidase activity	9	9.8	GO:0016997	alpha-sialidase activity
7	GO:0051998	protein carboxyl O-methyltransferase activity	17	9.72	"GO:0008276, GO:0010340"	"protein methyltransferase activity, carboxyl-O-methyltransferase activity"
6	GO:0008169	C-methyltransferase activity	12	9.72	GO:0008168	methyltransferase activity
6	GO:0070567	cytidylyltransferase activity	16	9.6	GO:0016779	nucleotidyltransferase activity
4	GO:0005539	glycosaminoglycan binding	14	9.6	GO:0097367	carbohydrate derivative binding
5	GO:0033764	"steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"	15	9.6	"GO:0016229, GO:0016616"	"steroid dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0016778	diphosphotransferase activity	16	9.6	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
6	GO:0070003	threonine-type peptidase activity	16	9.6	GO:0070011	"peptidase activity, acting on L-amino acid peptides"
5	GO:0016703	"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)"	16	9.6	"GO:0004497, GO:0016701"	"monooxygenase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"
4	GO:0048038	quinone binding	10	9.6	GO:0048037	cofactor binding
5	GO:0019902	phosphatase binding	17	9.56	GO:0019899	enzyme binding
7	GO:0015146	pentose transmembrane transporter activity	8	9.4	GO:0015145	monosaccharide transmembrane transporter activity
6	GO:0004753	saccharopine dehydrogenase activity	10	9.4	GO:0016646	"oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"
3	GO:0038024	cargo receptor activity	16	9.36	GO:0004872	receptor activity
6	GO:0017091	AU-rich element binding	10	9.2	GO:0003723	RNA binding
3	GO:0015459	potassium channel regulator activity	10	9.2	GO:0016247	channel regulator activity
6	GO:0003997	acyl-CoA oxidase activity	10	9.2	GO:0016634	"oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"
7	GO:0004529	exodeoxyribonuclease activity	27	9.14	"GO:0004536, GO:0004527"	"deoxyribonuclease activity, exonuclease activity"
8	GO:0016433	rRNA (adenine) methyltransferase activity	14	9.04	GO:0008649	rRNA methyltransferase activity
6	GO:0070815	peptidyl-lysine 5-dioxygenase activity	11	9	GO:0016706	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
6	GO:0031071	cysteine desulfurase activity	9	9	GO:0016783	sulfurtransferase activity
6	GO:0003951	NAD+ kinase activity	9	9	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
5	GO:0004124	cysteine synthase activity	9	9	GO:0016835	carbon-oxygen lyase activity
7	GO:0031127	"alpha-(1,2)-fucosyltransferase activity"	15	9	GO:0008417	fucosyltransferase activity
6	GO:0033608	formyl-CoA transferase activity	9	9	GO:0008410	CoA-transferase activity
4	GO:0043548	phosphatidylinositol 3-kinase binding	9	9	GO:0005515	protein binding
5	GO:0072542	protein phosphatase activator activity	9	9	"GO:0019888, GO:0019211"	"protein phosphatase regulator activity, phosphatase activator activity"
10	GO:0015087	cobalt ion transmembrane transporter activity	9	9	GO:0046915	transition metal ion transmembrane transporter activity
7	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	9	9	GO:0008374	O-acyltransferase activity
13	GO:0005250	A-type (transient outward) potassium channel activity	9	9	GO:0015271	outward rectifier potassium channel activity
6	GO:0004047	aminomethyltransferase activity	9	9	GO:0008168	methyltransferase activity
5	GO:0004075	biotin carboxylase activity	9	9	GO:0016879	"ligase activity, forming carbon-nitrogen bonds"
5	GO:0016421	CoA carboxylase activity	9	9	GO:0016885	"ligase activity, forming carbon-carbon bonds"
6	GO:0004867	serine-type endopeptidase inhibitor activity	9	9	GO:0004866	endopeptidase inhibitor activity
5	GO:0031997	N-terminal myristoylation domain binding	9	9	GO:0047485	protein N-terminus binding
5	GO:0016624	"oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"	11	9	GO:0016903	"oxidoreductase activity, acting on the aldehyde or oxo group of donors"
4	GO:0071889	14-3-3 protein binding	9	9	GO:0005515	protein binding
6	GO:0003910	DNA ligase (ATP) activity	9	9	GO:0003909	DNA ligase activity
10	GO:0043138	3'-5' DNA helicase activity	13	9	GO:0003678	DNA helicase activity
6	GO:0005459	UDP-galactose transmembrane transporter activity	9	9	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity
8	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	9	9	GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity
6	GO:0004040	amidase activity	9	9	GO:0016811	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"
6	GO:0004622	lysophospholipase activity	9	9	"GO:0052689, GO:0004620"	"carboxylic ester hydrolase activity, phospholipase activity"
7	GO:0004356	glutamate-ammonia ligase activity	9	9	GO:0016211	ammonia ligase activity
7	GO:0005046	KDEL sequence binding	9	9	GO:0046923	ER retention sequence binding
6	GO:0004733	pyridoxamine-phosphate oxidase activity	9	9	GO:0016641	"oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor"
9	GO:0051139	metal ion:hydrogen antiporter activity	15	9	"GO:0046873, GO:0015491, GO:0015299"	"metal ion transmembrane transporter activity, cation:cation antiporter activity, solute:hydrogen antiporter activity"
5	GO:0043274	phospholipase binding	9	9	GO:0019899	enzyme binding
5	GO:0034040	lipid-transporting ATPase activity	9	9	"GO:0042626, GO:0005319"	"ATPase activity, coupled to transmembrane movement of substances, lipid transporter activity"
5	GO:0016641	"oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor"	15	9	GO:0016638	"oxidoreductase activity, acting on the CH-NH2 group of donors"
5	GO:0016168	chlorophyll binding	9	9	GO:0046906	tetrapyrrole binding
7	GO:0051010	microtubule plus-end binding	9	9	GO:0008017	microtubule binding
4	GO:0000149	SNARE binding	14	8.84	GO:0005515	protein binding
6	GO:0051766	inositol trisphosphate kinase activity	14	8.8	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
4	GO:0016885	"ligase activity, forming carbon-carbon bonds"	11	8.8	GO:0016874	ligase activity
7	GO:0016427	tRNA (cytosine) methyltransferase activity	14	8.8	"GO:0008757, GO:0008175"	"S-adenosylmethionine-dependent methyltransferase activity, tRNA methyltransferase activity"
7	GO:0015296	anion:cation symporter activity	15	8.76	"GO:0008509, GO:0015294"	"anion transmembrane transporter activity, solute:cation symporter activity"
4	GO:0061135	endopeptidase regulator activity	19	8.76	GO:0061134	peptidase regulator activity
4	GO:0030613	"oxidoreductase activity, acting on phosphorus or arsenic in donors"	24	8.64	GO:0016491	oxidoreductase activity
6	GO:0019238	cyclohydrolase activity	18	8.64	GO:0016814	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"
6	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	9	8.6	GO:0016620	"oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"
4	GO:0001948	glycoprotein binding	9	8.6	GO:0005515	protein binding
8	GO:0015105	arsenite transmembrane transporter activity	13	8.52	GO:0015103	inorganic anion transmembrane transporter activity
4	GO:0015002	heme-copper terminal oxidase activity	14	8.4	GO:0016491	oxidoreductase activity
5	GO:0015203	polyamine transmembrane transporter activity	14	8.4	GO:0022891	substrate-specific transmembrane transporter activity
6	GO:0070546	L-phenylalanine aminotransferase activity	14	8.4	GO:0008483	transaminase activity
6	GO:0052742	phosphatidylinositol kinase activity	13	8.4	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
8	GO:0016434	rRNA (cytosine) methyltransferase activity	14	8.4	GO:0008649	rRNA methyltransferase activity
5	GO:0016813	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"	7	8.4	GO:0016810	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"
5	GO:0016676	"oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor"	14	8.4	GO:0016675	"oxidoreductase activity, acting on a heme group of donors"
4	GO:0016886	"ligase activity, forming phosphoric ester bonds"	19	8.28	GO:0016874	ligase activity
5	GO:0017022	myosin binding	11	8.25	GO:0008092	cytoskeletal protein binding
5	GO:0016647	"oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor"	7	8.2	GO:0016645	"oxidoreductase activity, acting on the CH-NH group of donors"
5	GO:0003909	DNA ligase activity	13	8.2	GO:0016886	"ligase activity, forming phosphoric ester bonds"
6	GO:0005347	ATP transmembrane transporter activity	9	8.2	"GO:0015211, GO:0005346, GO:0000295"	"purine nucleoside transmembrane transporter activity, purine ribonucleotide transmembrane transporter activity, adenine nucleotide transmembrane transporter activity"
3	GO:0032947	protein complex scaffold	9	8.2	"GO:0005515, GO:0005198"	"protein binding, structural molecule activity"
6	GO:0015217	ADP transmembrane transporter activity	9	8.2	"GO:0015211, GO:0005346, GO:0000295"	"purine nucleoside transmembrane transporter activity, purine ribonucleotide transmembrane transporter activity, adenine nucleotide transmembrane transporter activity"
4	GO:0030414	peptidase inhibitor activity	18	8.16	"GO:0004857, GO:0061134"	"enzyme inhibitor activity, peptidase regulator activity"
5	GO:0016615	malate dehydrogenase activity	12	8.16	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"
6	GO:0035257	nuclear hormone receptor binding	19	8.08	GO:0051427	hormone receptor binding
9	GO:0015278	calcium-release channel activity	12	8.04	"GO:0005262, GO:0015276"	"calcium channel activity, ligand-gated ion channel activity"
7	GO:0004813	alanine-tRNA ligase activity	8	8	GO:0004812	aminoacyl-tRNA ligase activity
7	GO:0030731	guanidinoacetate N-methyltransferase activity	8	8	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
6	GO:0004345	glucose-6-phosphate dehydrogenase activity	8	8	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0001786	phosphatidylserine binding	8	8	"GO:0005543, GO:0072341"	"phospholipid binding, modified amino acid binding"
6	GO:0008240	tripeptidyl-peptidase activity	8	8	"GO:0008238, GO:0008236"	"exopeptidase activity, serine-type peptidase activity"
6	GO:0019964	interferon-gamma binding	8	8	GO:0019961	interferon binding
4	GO:0008061	chitin binding	8	8	GO:0097367	carbohydrate derivative binding
7	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	8	8	GO:0004312	fatty acid synthase activity
8	GO:0003985	acetyl-CoA C-acetyltransferase activity	8	8	"GO:0016453, GO:0003988"	"C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity"
7	GO:0042409	caffeoyl-CoA O-methyltransferase activity	8	8	"GO:0008757, GO:0008171"	"S-adenosylmethionine-dependent methyltransferase activity, O-methyltransferase activity"
6	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	8	8	GO:0033764	"steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0003866	3-phosphoshikimate 1-carboxyvinyltransferase activity	8	8	GO:0016765	"transferase activity, transferring alkyl or aryl (other than methyl) groups"
6	GO:0043014	alpha-tubulin binding	8	8	GO:0015631	tubulin binding
6	GO:0008810	cellulase activity	8	8	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
5	GO:0070300	phosphatidic acid binding	8	8	GO:0005543	phospholipid binding
4	GO:0030276	clathrin binding	8	8	GO:0005515	protein binding
9	GO:0005223	intracellular cGMP activated cation channel activity	8	8	GO:0005221	intracellular cyclic nucleotide activated cation channel activity
7	GO:0016303	1-phosphatidylinositol-3-kinase activity	8	8	"GO:0035004, GO:0052742"	"phosphatidylinositol 3-kinase activity, phosphatidylinositol kinase activity"
5	GO:0008093	cytoskeletal adaptor activity	8	8	"GO:0030674, GO:0008092"	"protein binding, bridging, cytoskeletal protein binding"
6	GO:0070402	NADPH binding	8	8	"GO:0050661, GO:0043168"	"NADP binding, anion binding"
9	GO:0009035	Type I site-specific deoxyribonuclease activity	8	8	"GO:0016888, GO:0015666"	"endodeoxyribonuclease activity, producing 5'-phosphomonoesters, restriction endodeoxyribonuclease activity"
6	GO:0004649	poly(ADP-ribose) glycohydrolase activity	8	8	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
7	GO:0004826	phenylalanine-tRNA ligase activity	8	8	GO:0004812	aminoacyl-tRNA ligase activity
6	GO:0004499	"N,N-dimethylaniline monooxygenase activity"	8	8	GO:0016709	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"
5	GO:0004392	heme oxygenase (decyclizing) activity	8	8	GO:0016705	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"
5	GO:0033746	histone demethylase activity (H3-R2 specific)	8	8	GO:0032452	histone demethylase activity
7	GO:0050254	rhodopsin kinase activity	8	8	GO:0004672	protein kinase activity
6	GO:0008914	leucyltransferase activity	8	8	GO:0016755	"transferase activity, transferring amino-acyl groups"
8	GO:0008553	"hydrogen-exporting ATPase activity, phosphorylative mechanism"	8	8	"GO:0019829, GO:0015078, GO:0015662"	"cation-transporting ATPase activity, hydrogen ion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"
8	GO:0000405	bubble DNA binding	8	8	GO:0000217	DNA secondary structure binding
6	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	8	8	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0004764	shikimate 3-dehydrogenase (NADP+) activity	8	8	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
10	GO:0030898	actin-dependent ATPase activity	8	8	GO:0042623	"ATPase activity, coupled"
9	GO:0060072	large conductance calcium-activated potassium channel activity	8	8	GO:0015269	calcium-activated potassium channel activity
5	GO:0008601	protein phosphatase type 2A regulator activity	8	8	GO:0019888	protein phosphatase regulator activity
6	GO:0008271	secondary active sulfate transmembrane transporter activity	8	8	"GO:0015291, GO:0015116"	"secondary active transmembrane transporter activity, sulfate transmembrane transporter activity"
8	GO:0003935	GTP cyclohydrolase II activity	8	8	GO:0003933	GTP cyclohydrolase activity
6	GO:0051745	4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity	8	8	GO:0016726	"oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"
7	GO:0003957	NAD(P)+ transhydrogenase (B-specific) activity	8	8	"GO:0008746, GO:0015078"	"NAD(P)+ transhydrogenase activity, hydrogen ion transmembrane transporter activity"
7	GO:0004556	alpha-amylase activity	8	8	GO:0016160	amylase activity
5	GO:0033749	histone demethylase activity (H4-R3 specific)	8	8	GO:0032452	histone demethylase activity
8	GO:0019784	NEDD8-specific protease activity	8	8	GO:0019783	small conjugating protein-specific protease activity
4	GO:0019826	oxygen sensor activity	8	8	GO:0019825	oxygen binding
7	GO:0008239	dipeptidyl-peptidase activity	8	8	GO:0008238	exopeptidase activity
7	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	8	8	"GO:0009008, GO:0008757"	"DNA-methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity"
7	GO:0004830	tryptophan-tRNA ligase activity	8	8	GO:0004812	aminoacyl-tRNA ligase activity
8	GO:0035259	glucocorticoid receptor binding	8	8	GO:0035258	steroid hormone receptor binding
7	GO:0008409	5'-3' exonuclease activity	9	7.96	GO:0004527	exonuclease activity
4	GO:0019209	kinase activator activity	12	7.84	"GO:0008047, GO:0019207"	"enzyme activator activity, kinase regulator activity"
8	GO:0072349	modified amino acid transmembrane transporter activity	13	7.8	GO:0015171	amino acid transmembrane transporter activity
5	GO:0008410	CoA-transferase activity	13	7.8	GO:0016782	"transferase activity, transferring sulfur-containing groups"
7	GO:0004629	phospholipase C activity	11	7.8	"GO:0008081, GO:0004620"	"phosphoric diester hydrolase activity, phospholipase activity"
6	GO:0016409	palmitoyltransferase activity	10	7.76	GO:0016747	"transferase activity, transferring acyl groups other than amino-acyl groups"
7	GO:0004532	exoribonuclease activity	23	7.72	"GO:0004527, GO:0004540"	"exonuclease activity, ribonuclease activity"
5	GO:0004860	protein kinase inhibitor activity	13	7.72	"GO:0019210, GO:0019887"	"kinase inhibitor activity, protein kinase regulator activity"
3	GO:0019208	phosphatase regulator activity	20	7.66	GO:0030234	enzyme regulator activity
8	GO:0017048	Rho GTPase binding	10	7.6	GO:0017016	Ras GTPase binding
7	GO:0003964	RNA-directed DNA polymerase activity	8	7.6	GO:0034061	DNA polymerase activity
7	GO:0005365	myo-inositol transmembrane transporter activity	8	7.6	GO:0015166	polyol transmembrane transporter activity
7	GO:0004557	alpha-galactosidase activity	10	7.6	GO:0015925	galactosidase activity
8	GO:0000400	four-way junction DNA binding	7	7.6	GO:0000217	DNA secondary structure binding
4	GO:1901618	organic hydroxy compound transmembrane transporter activity	13	7.55	GO:0022857	transmembrane transporter activity
3	GO:0042562	hormone binding	14	7.52	GO:0005488	binding
6	GO:0000975	regulatory region DNA binding	17	7.41	"GO:0003677, GO:0001067"	"DNA binding, regulatory region nucleic acid binding"
12	GO:0005218	intracellular ligand-gated calcium channel activity	11	7.4	"GO:0015278, GO:0005217"	"calcium-release channel activity, intracellular ligand-gated ion channel activity"
5	GO:0016742	"hydroxymethyl-, formyl- and related transferase activity"	10	7.4	GO:0016741	"transferase activity, transferring one-carbon groups"
5	GO:0016841	ammonia-lyase activity	10	7.2	GO:0016840	carbon-nitrogen lyase activity
6	GO:0035004	phosphatidylinositol 3-kinase activity	8	7.2	GO:0016301	kinase activity
4	GO:0034072	squalene cyclase activity	12	7.2	GO:0009975	cyclase activity
4	GO:0051185	coenzyme transporter activity	12	7.2	GO:0051184	cofactor transporter activity
5	GO:0016682	"oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"	12	7.2	GO:0016679	"oxidoreductase activity, acting on diphenols and related substances as donors"
5	GO:0003714	transcription corepressor activity	8	7.2	GO:0003712	transcription cofactor activity
7	GO:0035173	histone kinase activity	11	7.12	GO:0004672	protein kinase activity
4	GO:0016725	"oxidoreductase activity, acting on CH or CH2 groups"	15	7.12	GO:0016491	oxidoreductase activity
7	GO:0008079	translation termination factor activity	15	7.08	GO:0008135	"translation factor activity, nucleic acid binding"
4	GO:0051861	glycolipid binding	9	7.08	GO:0008289	lipid binding
4	GO:0016840	carbon-nitrogen lyase activity	16	7.08	GO:0016829	lyase activity
7	GO:0008889	glycerophosphodiester phosphodiesterase activity	7	7	GO:0008081	phosphoric diester hydrolase activity
6	GO:0004658	propionyl-CoA carboxylase activity	7	7	GO:0016421	CoA carboxylase activity
6	GO:0009703	nitrate reductase (NADH) activity	7	7	"GO:0046857, GO:0008940"	"oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, nitrate reductase activity"
6	GO:0030060	L-malate dehydrogenase activity	7	7	"GO:0016616, GO:0016615"	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, malate dehydrogenase activity"
7	GO:0050236	pyridoxine:NADP 4-dehydrogenase activity	7	7	GO:0004033	aldo-keto reductase (NADP) activity
6	GO:0004416	hydroxyacylglutathione hydrolase activity	7	7	GO:0016790	thiolester hydrolase activity
6	GO:0008922	long-chain fatty acid [acyl-carrier-protein] ligase activity	7	7	"GO:0016878, GO:0015645"	"acid-thiol ligase activity, fatty acid ligase activity"
9	GO:0016314	"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"	7	7	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
5	GO:0051920	peroxiredoxin activity	7	7	GO:0016705	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"
7	GO:0005546	"phosphatidylinositol-4,5-bisphosphate binding"	7	7	GO:1901981	phosphatidylinositol phosphate binding
7	GO:0070530	K63-linked polyubiquitin binding	7	7	GO:0031593	polyubiquitin binding
5	GO:0051538	"3 iron, 4 sulfur cluster binding"	7	7	GO:0051536	iron-sulfur cluster binding
5	GO:0015576	sorbitol transmembrane transporter activity	7	7	"GO:0015144, GO:0022804, GO:0015166"	"carbohydrate transmembrane transporter activity, active transmembrane transporter activity, polyol transmembrane transporter activity"
9	GO:0016149	"translation release factor activity, codon specific"	7	7	GO:0003747	translation release factor activity
6	GO:0008336	gamma-butyrobetaine dioxygenase activity	7	7	GO:0016706	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
5	GO:0001540	beta-amyloid binding	7	7	GO:0042277	peptide binding
8	GO:0008199	ferric iron binding	7	7	GO:0005506	iron ion binding
7	GO:0015431	glutathione S-conjugate-exporting ATPase activity	7	7	GO:0071997	glutathione S-conjugate-transporting ATPase activity
6	GO:0016851	magnesium chelatase activity	7	7	GO:0051003	"ligase activity, forming nitrogen-metal bonds, forming coordination complexes"
7	GO:0004340	glucokinase activity	7	7	GO:0004396	hexokinase activity
4	GO:0044183	protein binding involved in protein folding	7	7	GO:0005515	protein binding
6	GO:0004765	shikimate kinase activity	7	7	"GO:0016301, GO:0016773"	"kinase activity, phosphotransferase activity, alcohol group as acceptor"
4	GO:0030332	cyclin binding	7	7	GO:0005515	protein binding
6	GO:0009044	"xylan 1,4-beta-xylosidase activity"	7	7	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
5	GO:0043559	insulin binding	7	7	GO:0017046	peptide hormone binding
4	GO:0008013	beta-catenin binding	7	7	GO:0005515	protein binding
7	GO:0003990	acetylcholinesterase activity	7	7	GO:0004104	cholinesterase activity
6	GO:0003987	acetate-CoA ligase activity	7	7	"GO:0016878, GO:0016405"	"acid-thiol ligase activity, CoA-ligase activity"
7	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	7	7	GO:0016307	phosphatidylinositol phosphate kinase activity
7	GO:0015446	arsenite-transmembrane transporting ATPase activity	7	7	"GO:0043225, GO:0019829, GO:0008490"	"anion transmembrane-transporting ATPase activity, cation-transporting ATPase activity, arsenite secondary active transmembrane transporter activity"
6	GO:0004807	triose-phosphate isomerase activity	7	7	GO:0016861	"intramolecular oxidoreductase activity, interconverting aldoses and ketoses"
4	GO:0030742	GTP-dependent protein binding	7	7	GO:0005515	protein binding
6	GO:0003855	3-dehydroquinate dehydratase activity	7	7	GO:0016836	hydro-lyase activity
6	GO:0018738	S-formylglutathione hydrolase activity	7	7	GO:0016790	thiolester hydrolase activity
5	GO:0031433	telethonin binding	7	7	GO:0008092	cytoskeletal protein binding
6	GO:0004749	ribose phosphate diphosphokinase activity	7	7	GO:0016778	diphosphotransferase activity
8	GO:0015148	D-xylose transmembrane transporter activity	7	7	GO:0015146	pentose transmembrane transporter activity
8	GO:0047689	aspartate racemase activity	7	7	GO:0047661	amino-acid racemase activity
8	GO:0032450	maltose alpha-glucosidase activity	7	7	GO:0004558	alpha-glucosidase activity
4	GO:0002039	p53 binding	7	7	GO:0005515	protein binding
4	GO:0005344	oxygen transporter activity	7	7	GO:0022892	substrate-specific transporter activity
7	GO:0004647	phosphoserine phosphatase activity	7	7	GO:0016791	phosphatase activity
5	GO:0004766	spermidine synthase activity	7	7	GO:0016765	"transferase activity, transferring alkyl or aryl (other than methyl) groups"
6	GO:0036054	protein-malonyllysine demalonylase activity	7	7	GO:0016811	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"
6	GO:0045552	dihydrokaempferol 4-reductase activity	7	7	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
7	GO:0003827	"alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"	7	7	GO:0008375	acetylglucosaminyltransferase activity
5	GO:0051786	"all-trans-retinol 13,14-reductase activity"	7	7	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
8	GO:0015591	D-ribose transmembrane transporter activity	7	7	GO:0015146	pentose transmembrane transporter activity
6	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	7	7	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0015575	mannitol transmembrane transporter activity	7	7	"GO:0015144, GO:0015166"	"carbohydrate transmembrane transporter activity, polyol transmembrane transporter activity"
6	GO:0036055	protein-succinyllysine desuccinylase activity	7	7	GO:0016811	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"
7	GO:0005080	protein kinase C binding	7	7	GO:0019901	protein kinase binding
5	GO:0016708	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor"	9	7	"GO:0016705, GO:0051213"	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, dioxygenase activity"
5	GO:0004802	transketolase activity	7	7	GO:0016744	"transferase activity, transferring aldehyde or ketonic groups"
5	GO:0008320	protein transmembrane transporter activity	10	6.96	"GO:0008565, GO:0022884"	"protein transporter activity, macromolecule transmembrane transporter activity"
6	GO:0000030	mannosyltransferase activity	10	6.84	GO:0016758	"transferase activity, transferring hexosyl groups"
8	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	10	6.8	GO:0052866	phosphatidylinositol phosphate phosphatase activity
9	GO:0005385	zinc ion transmembrane transporter activity	7	6.6	"GO:0072509, GO:0046915"	"divalent inorganic cation transmembrane transporter activity, transition metal ion transmembrane transporter activity"
6	GO:0070739	protein-glutamic acid ligase activity	11	6.6	GO:0016881	acid-amino acid ligase activity
4	GO:0019838	growth factor binding	11	6.6	GO:0005515	protein binding
4	GO:0016721	"oxidoreductase activity, acting on superoxide radicals as acceptor"	11	6.6	GO:0016491	oxidoreductase activity
6	GO:0008746	NAD(P)+ transhydrogenase activity	11	6.6	GO:0016652	"oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"
7	GO:0047617	acyl-CoA hydrolase activity	9	6.6	GO:0016289	CoA hydrolase activity
7	GO:0016426	tRNA (adenine) methyltransferase activity	11	6.6	"GO:0008757, GO:0008175"	"S-adenosylmethionine-dependent methyltransferase activity, tRNA methyltransferase activity"
7	GO:0034739	histone deacetylase activity (H4-K16 specific)	8	6.6	GO:0004407	histone deacetylase activity
5	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	7	6.6	GO:0019887	protein kinase regulator activity
6	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	7	6.6	"GO:0000702, GO:0003906"	"oxidized base lesion DNA N-glycosylase activity, DNA-(apurinic or apyrimidinic site) lyase activity"
6	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	7	6.6	"GO:0008320, GO:0015405"	"protein transmembrane transporter activity, P-P-bond-hydrolysis-driven transmembrane transporter activity"
4	GO:0016679	"oxidoreductase activity, acting on diphenols and related substances as donors"	18	6.48	GO:0016491	oxidoreductase activity
6	GO:0070548	L-glutamine aminotransferase activity	7	6.4	GO:0008483	transaminase activity
5	GO:0030295	protein kinase activator activity	8	6.4	"GO:0019209, GO:0019887"	"kinase activator activity, protein kinase regulator activity"
7	GO:0019204	nucleotide phosphatase activity	8	6.4	GO:0016791	phosphatase activity
4	GO:0034185	apolipoprotein binding	7	6.2	GO:0005515	protein binding
5	GO:0016714	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen"	6	6.2	"GO:0016705, GO:0004497"	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, monooxygenase activity"
3	GO:0017080	sodium channel regulator activity	7	6.2	GO:0016247	channel regulator activity
4	GO:0017046	peptide hormone binding	9	6.2	"GO:0042277, GO:0042562"	"peptide binding, hormone binding"
11	GO:0043142	single-stranded DNA-dependent ATPase activity	7	6.2	GO:0008094	DNA-dependent ATPase activity
4	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	8	6.16	GO:0003700	sequence-specific DNA binding transcription factor activity
4	GO:0005220	"inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity"	6	6	"GO:0015278, GO:0038023, GO:0005217"	"calcium-release channel activity, signaling receptor activity, intracellular ligand-gated ion channel activity"
5	GO:0008083	growth factor activity	6	6	GO:0005102	receptor binding
6	GO:0004359	glutaminase activity	6	6	GO:0016811	"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"
7	GO:0004824	lysine-tRNA ligase activity	6	6	GO:0004812	aminoacyl-tRNA ligase activity
4	GO:0016688	L-ascorbate peroxidase activity	6	6	GO:0004601	peroxidase activity
7	GO:0004970	ionotropic glutamate receptor activity	8	6	"GO:0005230, GO:0008066"	"extracellular ligand-gated ion channel activity, glutamate receptor activity"
5	GO:0046624	sphingolipid transporter activity	6	6	GO:0005319	lipid transporter activity
6	GO:0008875	gluconate dehydrogenase activity	10	6	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
7	GO:0000179	"rRNA (adenine-N6,N6-)-dimethyltransferase activity"	6	6	"GO:0008170, GO:0016433"	"N-methyltransferase activity, rRNA (adenine) methyltransferase activity"
6	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	6	6	GO:0016884	"carbon-nitrogen ligase activity, with glutamine as amido-N-donor"
7	GO:0003968	RNA-directed RNA polymerase activity	6	6	GO:0034062	RNA polymerase activity
4	GO:0000900	"translation repressor activity, nucleic acid binding"	6	6	"GO:0090079, GO:0030371"	"translation regulator activity, nucleic acid binding, translation repressor activity"
5	GO:0004637	phosphoribosylamine-glycine ligase activity	6	6	GO:0016879	"ligase activity, forming carbon-nitrogen bonds"
7	GO:0052655	L-valine transaminase activity	6	6	GO:0004084	branched-chain-amino-acid transaminase activity
6	GO:0004735	pyrroline-5-carboxylate reductase activity	6	6	GO:0016646	"oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"
7	GO:0003986	acetyl-CoA hydrolase activity	6	6	GO:0016289	CoA hydrolase activity
7	GO:0032129	histone deacetylase activity (H3-K9 specific)	10	6	GO:0004407	histone deacetylase activity
5	GO:0031683	G-protein beta/gamma-subunit complex binding	6	6	GO:0032403	protein complex binding
7	GO:0003830	"beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"	6	6	GO:0008375	acetylglucosaminyltransferase activity
8	GO:0009020	tRNA (guanosine-2'-O-)-methyltransferase activity	6	6	GO:0016423	tRNA (guanine) methyltransferase activity
7	GO:0008898	homocysteine S-methyltransferase activity	6	6	"GO:0008757, GO:0008172"	"S-adenosylmethionine-dependent methyltransferase activity, S-methyltransferase activity"
4	GO:0003876	AMP deaminase activity	6	6	"GO:0019239, GO:0016814"	"deaminase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"
6	GO:0043522	leucine zipper domain binding	6	6	GO:0030275	LRR domain binding
6	GO:0004108	citrate (Si)-synthase activity	6	6	GO:0046912	"transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"
7	GO:0052654	L-leucine transaminase activity	6	6	GO:0004084	branched-chain-amino-acid transaminase activity
9	GO:0004686	elongation factor-2 kinase activity	6	6	GO:0004683	calmodulin-dependent protein kinase activity
6	GO:0043958	acryloyl-CoA reductase activity	6	6	GO:0016628	"oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"
6	GO:0047964	glyoxylate reductase activity	6	6	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
6	GO:0004070	aspartate carbamoyltransferase activity	6	6	GO:0016743	carboxyl- or carbamoyltransferase activity
6	GO:0003885	"D-arabinono-1,4-lactone oxidase activity"	6	6	GO:0016899	"oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"
5	GO:0005125	cytokine activity	6	6	GO:0005102	receptor binding
7	GO:0008825	cyclopropane-fatty-acyl-phospholipid synthase activity	6	6	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
6	GO:0008942	nitrite reductase [NAD(P)H] activity	6	6	GO:0046857	"oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"
9	GO:0004439	"phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"	6	6	"GO:0034593, GO:0034595"	"phosphatidylinositol bisphosphate phosphatase activity, phosphatidylinositol phosphate 5-phosphatase activity"
6	GO:0003978	UDP-glucose 4-epimerase activity	6	6	GO:0016857	"racemase and epimerase activity, acting on carbohydrates and derivatives"
13	GO:0005219	ryanodine-sensitive calcium-release channel activity	6	6	GO:0005218	intracellular ligand-gated calcium channel activity
7	GO:0004430	1-phosphatidylinositol 4-kinase activity	6	6	GO:0052742	phosphatidylinositol kinase activity
6	GO:0042288	MHC class I protein binding	6	6	GO:0042287	MHC protein binding
6	GO:0003834	"beta-carotene 15,15'-monooxygenase activity"	6	6	GO:0016702	"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"
8	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	6	6	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity
6	GO:0004853	uroporphyrinogen decarboxylase activity	6	6	GO:0016831	carboxy-lyase activity
5	GO:0034634	glutathione transmembrane transporter activity	6	6	"GO:1901682, GO:0072349, GO:0042937, GO:0035673"	"sulfur compound transmembrane transporter activity, modified amino acid transmembrane transporter activity, tripeptide transporter activity, oligopeptide transmembrane transporter activity"
6	GO:0008508	bile acid:sodium symporter activity	6	6	"GO:0015296, GO:0015125, GO:0005343"	"anion:cation symporter activity, bile acid transmembrane transporter activity, organic acid:sodium symporter activity"
8	GO:0004781	sulfate adenylyltransferase (ATP) activity	6	6	GO:0004779	sulfate adenylyltransferase activity
7	GO:0051721	protein phosphatase 2A binding	6	6	GO:0019903	protein phosphatase binding
9	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	6	6	GO:0004722	protein serine/threonine phosphatase activity
8	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	6	6	"GO:0017136, GO:0031078"	"NAD-dependent histone deacetylase activity, histone deacetylase activity (H3-K14 specific)"
5	GO:0000215	tRNA 2'-phosphotransferase activity	6	6	"GO:0016773, GO:0008665"	"phosphotransferase activity, alcohol group as acceptor, 2'-phosphotransferase activity"
5	GO:0017124	SH3 domain binding	6	6	GO:0019904	protein domain specific binding
6	GO:0003989	acetyl-CoA carboxylase activity	6	6	GO:0016421	CoA carboxylase activity
7	GO:0004828	serine-tRNA ligase activity	6	6	GO:0004812	aminoacyl-tRNA ligase activity
5	GO:0032795	heterotrimeric G-protein binding	6	6	GO:0032403	protein complex binding
7	GO:0033717	gluconate 2-dehydrogenase (acceptor) activity	6	6	GO:0008875	gluconate dehydrogenase activity
7	GO:0008780	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	6	6	GO:0008374	O-acyltransferase activity
8	GO:0016290	palmitoyl-CoA hydrolase activity	6	6	GO:0047617	acyl-CoA hydrolase activity
7	GO:0046538	"2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"	6	6	GO:0004619	phosphoglycerate mutase activity
6	GO:0003958	NADPH-hemoprotein reductase activity	6	6	GO:0016653	"oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"
7	GO:0004862	cAMP-dependent protein kinase inhibitor activity	6	6	GO:0030291	protein serine/threonine kinase inhibitor activity
7	GO:0004818	glutamate-tRNA ligase activity	6	6	GO:0004812	aminoacyl-tRNA ligase activity
6	GO:0018801	glutaconyl-CoA decarboxylase activity	6	6	GO:0016831	carboxy-lyase activity
5	GO:0016713	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen"	7	6	"GO:0016705, GO:0004497"	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, monooxygenase activity"
7	GO:0052656	L-isoleucine transaminase activity	6	6	GO:0004084	branched-chain-amino-acid transaminase activity
6	GO:0004311	farnesyltranstransferase activity	7	6	GO:0004659	prenyltransferase activity
8	GO:0030331	estrogen receptor binding	6	6	GO:0035258	steroid hormone receptor binding
5	GO:0016743	carboxyl- or carbamoyltransferase activity	10	6	GO:0016741	"transferase activity, transferring one-carbon groups"
4	GO:0032767	copper-dependent protein binding	6	6	GO:0005515	protein binding
6	GO:0005324	long-chain fatty acid transporter activity	6	6	GO:0015245	fatty acid transporter activity
6	GO:0008121	ubiquinol-cytochrome-c reductase activity	6	6	"GO:0016681, GO:0015078"	"oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor, hydrogen ion transmembrane transporter activity"
7	GO:0050321	tau-protein kinase activity	6	6	GO:0004672	protein kinase activity
4	GO:0004096	catalase activity	6	6	GO:0004601	peroxidase activity
5	GO:0051003	"ligase activity, forming nitrogen-metal bonds, forming coordination complexes"	7	6	GO:0051002	"ligase activity, forming nitrogen-metal bonds"
7	GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	6	GO:0070567	cytidylyltransferase activity
6	GO:0016162	"cellulose 1,4-beta-cellobiosidase activity"	6	6	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
6	GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	6	6	"GO:0016634, GO:0070818"	"oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor, protoporphyrinogen oxidase activity"
8	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	6	6	GO:0016274	protein-arginine N-methyltransferase activity
9	GO:0004698	calcium-dependent protein kinase C activity	6	6	"GO:0009931, GO:0004697"	"calcium-dependent protein serine/threonine kinase activity, protein kinase C activity"
6	GO:0008465	glycerate dehydrogenase activity	6	6	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
5	GO:0016987	sigma factor activity	6	6	GO:0000996	core DNA-dependent RNA polymerase binding promoter specificity activity
6	GO:0042903	tubulin deacetylase activity	6	6	"GO:0033558, GO:0016811"	"protein deacetylase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"
8	GO:0003846	2-acylglycerol O-acyltransferase activity	6	6	GO:0016411	acylglycerol O-acyltransferase activity
6	GO:0016756	glutathione gamma-glutamylcysteinyltransferase activity	6	6	GO:0016755	"transferase activity, transferring amino-acyl groups"
9	GO:0048365	Rac GTPase binding	6	6	GO:0017048	Rho GTPase binding
8	GO:0016208	AMP binding	6	6	"GO:0043169, GO:0032559, GO:0043168, GO:0032550"	"cation binding, adenyl ribonucleotide binding, anion binding, purine ribonucleoside binding"
8	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	6	6	"GO:0017136, GO:0034739"	"NAD-dependent histone deacetylase activity, histone deacetylase activity (H4-K16 specific)"
6	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	6	6	GO:0003713	transcription coactivator activity
8	GO:0052692	raffinose alpha-galactosidase activity	6	6	GO:0004557	alpha-galactosidase activity
6	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	6	6	GO:0016616	"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
7	GO:0004605	phosphatidate cytidylyltransferase activity	6	6	GO:0070567	cytidylyltransferase activity
5	GO:0016652	"oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"	13	5.96	GO:0016651	"oxidoreductase activity, acting on NAD(P)H"
6	GO:0016997	alpha-sialidase activity	9	5.88	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
8	GO:0015175	neutral amino acid transmembrane transporter activity	6	5.88	GO:0015171	amino acid transmembrane transporter activity
3	GO:0061134	peptidase regulator activity	21	5.83	GO:0030234	enzyme regulator activity
7	GO:0010340	carboxyl-O-methyltransferase activity	17	5.83	GO:0008171	O-methyltransferase activity
8	GO:0015666	restriction endodeoxyribonuclease activity	9	5.8	GO:0004520	endodeoxyribonuclease activity
6	GO:0000339	RNA cap binding	7	5.8	GO:0003723	RNA binding
5	GO:0008940	nitrate reductase activity	8	5.8	GO:0016661	"oxidoreductase activity, acting on other nitrogenous compounds as donors"
5	GO:0016880	acid-ammonia (or amide) ligase activity	13	5.64	GO:0016879	"ligase activity, forming carbon-nitrogen bonds"
5	GO:0070491	repressing transcription factor binding	6	5.6	GO:0008134	transcription factor binding
4	GO:0016872	intramolecular lyase activity	8	5.6	GO:0016853	isomerase activity
8	GO:0015370	solute:sodium symporter activity	11	5.56	"GO:0015081, GO:0015294"	"sodium ion transmembrane transporter activity, solute:cation symporter activity"
3	GO:0051183	vitamin transporter activity	11	5.5	GO:0005215	transporter activity
4	GO:0019211	phosphatase activator activity	9	5.4	"GO:0019208, GO:0008047"	"phosphatase regulator activity, enzyme activator activity"
5	GO:0001104	RNA polymerase II transcription cofactor activity	7	5.4	"GO:0001076, GO:0003712"	"RNA polymerase II transcription factor binding transcription factor activity, transcription cofactor activity"
7	GO:0015301	anion:anion antiporter activity	9	5.4	"GO:0008509, GO:0015297"	"anion transmembrane transporter activity, antiporter activity"
5	GO:0016774	"phosphotransferase activity, carboxyl group as acceptor"	9	5.4	GO:0016772	"transferase activity, transferring phosphorus-containing groups"
7	GO:0003933	GTP cyclohydrolase activity	9	5.4	GO:0019238	cyclohydrolase activity
6	GO:0009008	DNA-methyltransferase activity	9	5.4	GO:0008168	methyltransferase activity
5	GO:0016723	"oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor"	9	5.4	GO:0016722	"oxidoreductase activity, oxidizing metal ions"
5	GO:0016726	"oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"	9	5.4	GO:0016725	"oxidoreductase activity, acting on CH or CH2 groups"
6	GO:0005343	organic acid:sodium symporter activity	9	5.4	"GO:0005342, GO:0015370"	"organic acid transmembrane transporter activity, solute:sodium symporter activity"
7	GO:0016453	C-acetyltransferase activity	9	5.4	"GO:0016408, GO:0016407"	"C-acyltransferase activity, acetyltransferase activity"
6	GO:0016211	ammonia ligase activity	9	5.4	GO:0016880	acid-ammonia (or amide) ligase activity
5	GO:0004457	lactate dehydrogenase activity	9	5.4	GO:0016614	"oxidoreductase activity, acting on CH-OH group of donors"
10	GO:0005375	copper ion transmembrane transporter activity	9	5.24	GO:0046915	transition metal ion transmembrane transporter activity
4	GO:0016675	"oxidoreductase activity, acting on a heme group of donors"	14	5.04	GO:0016491	oxidoreductase activity
6	GO:0004645	phosphorylase activity	7	5	GO:0016758	"transferase activity, transferring hexosyl groups"
8	GO:0015112	nitrate transmembrane transporter activity	7	5	GO:0015103	inorganic anion transmembrane transporter activity
7	GO:0015038	glutathione disulfide oxidoreductase activity	7	5	GO:0015037	peptide disulfide oxidoreductase activity
5	GO:0051427	hormone receptor binding	19	4.85	GO:0005102	receptor binding
6	GO:0016160	amylase activity	8	4.8	GO:0004553	"hydrolase activity, hydrolyzing O-glycosyl compounds"
7	GO:0015142	tricarboxylic acid transmembrane transporter activity	8	4.8	GO:0046943	carboxylic acid transmembrane transporter activity
5	GO:0015125	bile acid transmembrane transporter activity	8	4.8	"GO:0008028, GO:0005319"	"monocarboxylic acid transmembrane transporter activity, lipid transporter activity"
5	GO:0000104	succinate dehydrogenase activity	6	4.8	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
5	GO:0019961	interferon binding	8	4.8	GO:0019955	cytokine binding
5	GO:0016635	"oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor"	7	4.72	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
6	GO:0033293	monocarboxylic acid binding	10	4.68	GO:0031406	carboxylic acid binding
7	GO:0000702	oxidized base lesion DNA N-glycosylase activity	8	4.68	GO:0019104	DNA N-glycosylase activity
10	GO:0005381	iron ion transmembrane transporter activity	7	4.68	GO:0046915	transition metal ion transmembrane transporter activity
4	GO:0019210	kinase inhibitor activity	13	4.63	"GO:0004857, GO:0019207"	"enzyme inhibitor activity, kinase regulator activity"
5	GO:0008066	glutamate receptor activity	9	4.6	GO:0004888	transmembrane signaling receptor activity
4	GO:0051018	protein kinase A binding	7	4.6	GO:0005515	protein binding
6	GO:0042937	tripeptide transporter activity	7	4.6	GO:0015198	oligopeptide transporter activity
4	GO:0001076	RNA polymerase II transcription factor binding transcription factor activity	9	4.44	GO:0000989	transcription factor binding transcription factor activity
5	GO:0001067	regulatory region nucleic acid binding	17	4.45	GO:0003676	nucleic acid binding
5	GO:0005126	cytokine receptor binding	8	4.44	GO:0005102	receptor binding
4	GO:0031369	translation initiation factor binding	6	4.4	GO:0005515	protein binding
6	GO:0008490	arsenite secondary active transmembrane transporter activity	7	4.2	"GO:0015291, GO:0015105"	"secondary active transmembrane transporter activity, arsenite transmembrane transporter activity"
7	GO:0004779	sulfate adenylyltransferase activity	7	4.2	GO:0070566	adenylyltransferase activity
6	GO:0030291	protein serine/threonine kinase inhibitor activity	7	4.2	GO:0004860	protein kinase inhibitor activity
6	GO:0036002	pre-mRNA binding	7	4.2	GO:0003723	RNA binding
3	GO:0090079	"translation regulator activity, nucleic acid binding"	7	4.2	"GO:0045182, GO:0003676"	"translation regulator activity, nucleic acid binding"
8	GO:0016892	"endoribonuclease activity, producing 3'-phosphomonoesters"	7	4.2	"GO:0004521, GO:0016894"	"endoribonuclease activity, endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"
6	GO:0004396	hexokinase activity	7	4.2	"GO:0016773, GO:0019200"	"phosphotransferase activity, alcohol group as acceptor, carbohydrate kinase activity"
8	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	7	4.2	GO:0052866	phosphatidylinositol phosphate phosphatase activity
6	GO:0071997	glutathione S-conjugate-transporting ATPase activity	7	4.2	GO:0042626	"ATPase activity, coupled to transmembrane movement of substances"
5	GO:0022884	macromolecule transmembrane transporter activity	10	4.18	GO:0022891	substrate-specific transmembrane transporter activity
6	GO:0015037	peptide disulfide oxidoreductase activity	8	4	GO:0015036	disulfide oxidoreductase activity
5	GO:0016639	"oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"	7	4	GO:0016638	"oxidoreductase activity, acting on the CH-NH2 group of donors"
5	GO:0016712	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"	6	4	"GO:0016705, GO:0004497"	"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, monooxygenase activity"
7	GO:0016894	"endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"	11	3.96	GO:0004519	endonuclease activity
5	GO:0016803	ether hydrolase activity	7	3.94	GO:0016801	"hydrolase activity, acting on ether bonds"
7	GO:0008028	monocarboxylic acid transmembrane transporter activity	10	3.7	GO:0046943	carboxylic acid transmembrane transporter activity
3	GO:0030371	translation repressor activity	6	3.6	GO:0045182	translation regulator activity
5	GO:0015245	fatty acid transporter activity	6	3.6	GO:0005319	lipid transporter activity
5	GO:0016681	"oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor"	6	3.6	GO:0016679	"oxidoreductase activity, acting on diphenols and related substances as donors"
7	GO:0004549	tRNA-specific ribonuclease activity	6	3.6	GO:0004540	ribonuclease activity
3	GO:0042165	neurotransmitter binding	6	3.6	GO:0005488	binding
4	GO:0051002	"ligase activity, forming nitrogen-metal bonds"	7	3.6	GO:0016874	ligase activity
7	GO:0031078	histone deacetylase activity (H3-K14 specific)	6	3.6	GO:0004407	histone deacetylase activity
5	GO:0030275	LRR domain binding	6	3.6	GO:0019904	protein domain specific binding
4	GO:0016722	"oxidoreductase activity, oxidizing metal ions"	10	3.6	GO:0016491	oxidoreductase activity
4	GO:0008665	2'-phosphotransferase activity	6	3.6	GO:0016740	transferase activity
6	GO:0016215	acyl-CoA desaturase activity	6	3.6	GO:0016717	"oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"
7	GO:0016418	S-acetyltransferase activity	6	3.6	"GO:0016417, GO:0016407"	"S-acyltransferase activity, acetyltransferase activity"
7	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	6	3.6	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
8	GO:0009931	calcium-dependent protein serine/threonine kinase activity	6	3.6	"GO:0010857, GO:0004674"	"calcium-dependent protein kinase activity, protein serine/threonine kinase activity"
8	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	6	3.6	GO:0052866	phosphatidylinositol phosphate phosphatase activity
5	GO:0070818	protoporphyrinogen oxidase activity	6	3.6	GO:0016627	"oxidoreductase activity, acting on the CH-CH group of donors"
5	GO:0042287	MHC protein binding	6	3.6	GO:0005102	receptor binding
4	GO:0000996	core DNA-dependent RNA polymerase binding promoter specificity activity	6	3.6	GO:0000990	core RNA polymerase binding transcription factor activity
4	GO:0019955	cytokine binding	9	3.48	GO:0005515	protein binding
3	GO:0000990	core RNA polymerase binding transcription factor activity	7	3.16	GO:0000988	protein binding transcription factor activity
2	GO:0045182	translation regulator activity	7	2.52	GO:0003674	molecular_function
4	GO:0016730	"oxidoreductase activity, acting on iron-sulfur proteins as donors"	6	2.4	GO:0016491	oxidoreductase activity
4	GO:0016801	"hydrolase activity, acting on ether bonds"	7	2.36	GO:0016787	hydrolase activity
7	GO:0010857	calcium-dependent protein kinase activity	6	2.16	GO:0004672	protein kinase activity