GO ID GO term # of S. cerevisiae annotations (direct and indirect) # of expert votes (out of 6) GO:0043037 translation 422 4 GO:0007001 chromosome organization and biogenesis (sensu Eukaryota) 329 4 GO:0006082 organic acid metabolism 302 4 GO:0016192 vesicle-mediated transport 287 4 GO:0006366 transcription from RNA polymerase II promoter 282 5 GO:0000279 M phase 262 6 GO:0045184 establishment of protein localization 259 4 GO:0016072 rRNA metabolism 249 4 GO:0006807 nitrogen compound metabolism 237 6 GO:0000278 mitotic cell cycle 234 4 GO:0006629 lipid metabolism 229 4 GO:0005975 carbohydrate metabolism 222 6 GO:0007010 cytoskeleton organization and biogenesis 213 4 GO:0007046 ribosome biogenesis 209 4 GO:0006323 DNA packaging 209 6 GO:0006519 amino acid and derivative metabolism 199 5 GO:0050876 reproductive physiological process 195 5 GO:0006793 phosphorus metabolism 192 5 GO:0006310 DNA recombination 192 6 GO:0016071 mRNA metabolism 188 4 GO:0006974 response to DNA damage stimulus 183 5 GO:0006508 proteolysis 165 5 GO:0006066 alcohol metabolism 160 5 GO:0000902 cellular morphogenesis 156 4 GO:0051186 cofactor metabolism 153 4 GO:0006461 protein complex assembly 152 4 GO:0007047 cell wall organization and biogenesis 148 4 GO:0000074 regulation of progression through cell cycle 144 5 GO:0051321 meiotic cell cycle 133 5 GO:0008380 RNA splicing 129 4 GO:0016481 negative regulation of transcription 129 4 GO:0051301 cell division 128 4 GO:0006913 nucleocytoplasmic transport 112 5 GO:0006811 ion transport 110 4 GO:0030435 sporulation 107 4 GO:0007059 chromosome segregation 107 4 GO:0019953 sexual reproduction 106 4 GO:0051169 nuclear transport 106 5 GO:0050801 ion homeostasis 106 4 GO:0006399 tRNA metabolism 104 5 GO:0006260 DNA replication 103 5 GO:0007005 mitochondrion organization and biogenesis 101 5 GO:0009117 nucleotide metabolism 94 4 GO:0045333 cellular respiration 90 5 GO:0030447 filamentous growth 90 4 GO:0051325 interphase 89 5 GO:0040029 "regulation of gene expression, epigenetic" 84 4 GO:0015931 "nucleobase, nucleoside, nucleotide and nucleic acid transport" 83 4 GO:0019954 asexual reproduction 82 4 GO:0016458 gene silencing 79 5 GO:0006766 vitamin metabolism 78 5 GO:0009100 glycoprotein metabolism 75 5 GO:0051236 establishment of RNA localization 74 5 GO:0019236 response to pheromone 74 5 GO:0046483 heterocycle metabolism 72 4 GO:0006512 ubiquitin cycle 72 6 GO:0006457 protein folding 70 6 GO:0045941 positive regulation of transcription 68 4 GO:0006401 RNA catabolism 64 4 GO:0007034 vacuolar transport 64 5 GO:0006944 membrane fusion 60 5 GO:0006970 response to osmotic stress 59 6 GO:0006790 sulfur metabolism 58 6 GO:0006352 transcription initiation 57 6 GO:0006725 aromatic compound metabolism 57 6 GO:0006800 oxygen and reactive oxygen species metabolism 56 6 GO:0007264 small GTPase mediated signal transduction 55 5 GO:0015849 organic acid transport 52 4 GO:0006997 nuclear organization and biogenesis 49 5 GO:0015837 amine transport 48 5 GO:0008219 cell death 46 4 GO:0042157 lipoprotein metabolism 45 5 GO:0007568 aging 42 4 GO:0007033 vacuole organization and biogenesis 41 4 GO:0007166 cell surface receptor linked signal transduction 40 4 GO:0006383 transcription from RNA polymerase III promoter 38 6 GO:0006473 protein amino acid acetylation 38 5 GO:0007031 peroxisome organization and biogenesis 38 5 GO:0048308 organelle inheritance 38 4 GO:0006417 regulation of protein biosynthesis 37 4 GO:0006112 energy reserve metabolism 36 6 GO:0006914 autophagy 36 5 GO:0008643 carbohydrate transport 34 5 GO:0016485 protein processing 32 5 GO:0006118 electron transport 31 6 GO:0043284 biopolymer biosynthesis 30 4 GO:0045185 maintenance of protein localization 29 5 GO:0006360 transcription from RNA polymerase I promoter 28 6 GO:0019932 second-messenger-mediated signaling 28 5 GO:0006354 RNA elongation 26 6 GO:0050790 regulation of enzyme activity 26 5 GO:0006869 lipid transport 25 6 GO:0006818 hydrogen transport 24 6 GO:0019748 secondary metabolism 24 4 GO:0051252 regulation of RNA metabolism 24 6 GO:0007530 sex determination 23 4 GO:0031123 RNA 3'-end processing 22 4 GO:0051052 regulation of DNA metabolism 21 5 GO:0018193 peptidyl-amino acid modification 21 5 GO:0010035 response to inorganic substance 20 4 GO:0007243 protein kinase cascade 20 5 GO:0008213 protein amino acid alkylation 20 5 GO:0009266 response to temperature stimulus 20 5 GO:0040023 establishment of nucleus localization 20 6 GO:0006081 aldehyde metabolism 19 6 GO:0007155 cell adhesion 18 4 GO:0048284 organelle fusion 17 5 GO:0006113 fermentation 17 6 GO:0043094 metabolic compound salvage 17 5 GO:0006353 transcription termination 17 6 GO:0030705 cytoskeleton-dependent intracellular transport 16 5 GO:0042594 response to starvation 16 4 GO:0009116 nucleoside metabolism 15 5 GO:0001510 RNA methylation 15 6 GO:0031023 microtubule organizing center organization and biogenesis 14 4 GO:0006476 protein amino acid deacetylation 14 6 GO:0006986 response to unfolded protein 14 6 GO:0015893 drug transport 13 4 GO:0016074 snoRNA metabolism 13 5 GO:0000160 two-component signal transduction system (phosphorelay) 12 6 GO:0006056 mannoprotein metabolism 12 6 GO:0006730 one-carbon compound metabolism 12 6 GO:0006308 DNA catabolism 12 6 GO:0016050 vesicle organization and biogenesis 12 5 GO:0006839 mitochondrial transport 11 6 GO:0030261 chromosome condensation 11 6 GO:0008298 intracellular mRNA localization 10 5 GO:0009415 response to water 10 5 GO:0045454 cell redox homeostasis 10 5 GO:0007039 vacuolar protein catabolism 10 5 GO:0015891 siderophore transport 9 5 GO:0051248 negative regulation of protein metabolism 9 5 GO:0006276 plasmid maintenance 9 6 GO:0051261 protein depolymerization 8 4 GO:0006518 peptide metabolism 8 5 GO:0051049 regulation of transport 8 5 GO:0007584 response to nutrient 8 4 GO:0006280 mutagenesis 7 6 GO:0016925 protein sumoylation 7 5 GO:0009410 response to xenobiotic stimulus 7 5 GO:0001522 pseudouridine synthesis 7 6 GO:0007009 plasma membrane organization and biogenesis 7 4 GO:0009743 response to carbohydrate stimulus 6 4 GO:0015791 polyol transport 6 5 GO:0051180 vitamin transport 6 6 GO:0045116 protein neddylation 6 5 GO:0051181 cofactor transport 6 5 GO:0000338 protein deneddylation 5 6 GO:0051129 negative regulation of cell organization and biogenesis 5 4 GO:0007029 endoplasmic reticulum organization and biogenesis 5 5 GO:0009225 nucleotide-sugar metabolism 5 5 GO:0006265 DNA topological change 5 6 GO:0006984 ER-nuclear signaling pathway 5 6 GO:0009636 response to toxin 5 4 GO:0018410 peptide or protein carboxyl-terminal blocking 5 5 GO:0009452 RNA capping 4 5 GO:0015833 peptide transport 4 5 GO:0016073 snRNA metabolism 4 5 GO:0018065 protein-cofactor linkage 4 5 GO:0042180 ketone metabolism 4 5 GO:0048285 organelle fission 4 5 GO:0006662 glycerol ether metabolism 4 6 GO:0042176 regulation of protein catabolism 3 6 GO:0009268 response to pH 3 5 GO:0017006 protein-tetrapyrrole linkage 3 5 GO:0042044 fluid transport 3 5 GO:0050874 organismal physiological process 3 5 GO:0006390 transcription from mitochondrial promoter 3 6 GO:0000280 nuclear division 3 4 GO:0009966 regulation of signal transduction 2 4 GO:0015976 carbon utilization 2 4 GO:0009303 rRNA transcription 2 5 GO:0009847 spore germination 2 5 GO:0016926 protein desumoylation 2 5 GO:0018987 osmoregulation 2 5 GO:0051238 sequestering of metal ion 2 5 GO:0044419 interspecies interaction between organisms 2 4 GO:0007030 Golgi organization and biogenesis 2 5 GO:0009314 response to radiation 2 5 GO:0042214 terpene metabolism 2 5 GO:0045595 regulation of cell differentiation 1 4 GO:0046713 boron transport 1 4 GO:0051258 protein polymerization 1 4 GO:0001101 response to acid 1 5 GO:0007624 ultradian rhythm 1 5 GO:0009302 snoRNA transcription 1 5 GO:0009305 protein amino acid biotinylation 1 5 GO:0016998 cell wall catabolism 1 5 GO:0030397 membrane disassembly 1 5 GO:0045471 response to ethanol 1 5 GO:0046677 response to antibiotic 1 5 GO:0050821 protein stabilization 1 5 GO:0006033 chitin localization 1 6 GO:0006266 DNA ligation 1 6 GO:0006858 extracellular transport 1 6 GO:0007032 endosome organization and biogenesis 0 4 GO:0009581 detection of external stimulus 0 4 GO:0016032 viral life cycle 0 4 GO:0001410 chlamydospore formation (sensu Candida albicans) 0 4 GO:0001570 vasculogenesis 0 4 GO:0001742 oenocyte differentiation 0 4 GO:0001826 inner cell mass cell differentiation 0 4 GO:0001829 trophectodermal cell differentiation 0 4 GO:0001833 inner cell mass cell proliferation 0 4 GO:0001834 trophectodermal cell proliferation 0 4 GO:0001837 epithelial to mesenchymal transition 0 4 GO:0001920 negative regulation of receptor recycling 0 4 GO:0001921 positive regulation of receptor recycling 0 4 GO:0001935 endothelial cell proliferation 0 4 GO:0001941 postsynaptic membrane organization 0 4 GO:0006884 regulation of cell volume 0 4 GO:0007164 establishment of tissue polarity 0 4 GO:0007405 neuroblast proliferation 0 4 GO:0007514 garland cell differentiation 0 4 GO:0007623 circadian rhythm 0 4 GO:0008037 cell recognition 0 4 GO:0008058 ocellus pigment granule organization and biogenesis 0 4 GO:0008582 regulation of synaptic growth at neuromuscular junction 0 4 GO:0009300 antisense RNA transcription 0 4 GO:0009301 snRNA transcription 0 4 GO:0009304 tRNA transcription 0 4 GO:0009432 SOS response 0 4 GO:0009582 detection of abiotic stimulus 0 4 GO:0009595 detection of biotic stimulus 0 4 GO:0009668 plastid membrane organization and biogenesis 0 4 GO:0009689 induction of phytoalexin biosynthesis 0 4 GO:0009886 post-embryonic morphogenesis 0 4 GO:0009890 negative regulation of biosynthesis 0 4 GO:0009896 positive regulation of catabolism 0 4 GO:0009913 epidermal cell differentiation 0 4 GO:0010001 glial cell differentiation 0 4 GO:0010034 response to acetate 0 4 GO:0019093 mitochondrial RNA localization 0 4 GO:0030099 myeloid cell differentiation 0 4 GO:0030182 neuron differentiation 0 4 GO:0030216 keratinocyte differentiation 0 4 GO:0030855 epithelial cell differentiation 0 4 GO:0031077 post-embryonic eye development (sensu Actinopterygii) 0 4 GO:0031155 regulation of fruiting body formation 0 4 GO:0035051 cardiac cell differentiation 0 4 GO:0035166 post-embryonic hemopoiesis 0 4 GO:0035172 hemocyte proliferation (sensu Arthropoda) 0 4 GO:0035212 cell competition (sensu Metazoa) 0 4 GO:0040014 regulation of body size 0 4 GO:0040028 regulation of vulval development (sensu Nematoda) 0 4 GO:0042127 regulation of cell proliferation 0 4 GO:0042262 DNA protection 0 4 GO:0042386 hemocyte differentiation (sensu Arthropoda) 0 4 GO:0042391 regulation of membrane potential 0 4 GO:0042490 mechanoreceptor differentiation 0 4 GO:0042593 glucose homeostasis 0 4 GO:0042632 cholesterol homeostasis 0 4 GO:0042675 cone cell differentiation 0 4 GO:0042692 muscle cell differentiation 0 4 GO:0042793 transcription from plastid promoter 0 4 GO:0043158 heterocyst differentiation 0 4 GO:0043165 outer membrane biogenesis (sensu Proteobacteria) 0 4 GO:0043181 vacuolar sequestering 0 4 GO:0043244 regulation of protein complex disassembly 0 4 GO:0043279 response to alkaloid 0 4 GO:0045165 cell fate commitment 0 4 GO:0045304 regulation of establishment of competence for transformation 0 4 GO:0045444 fat cell differentiation 0 4 GO:0045446 endothelial cell differentiation 0 4 GO:0045472 response to ether 0 4 GO:0045682 regulation of epidermis development 0 4 GO:0045730 respiratory burst 0 4 GO:0045995 regulation of embryonic development 0 4 GO:0046530 photoreceptor cell differentiation 0 4 GO:0046620 regulation of organ size 0 4 GO:0046886 positive regulation of hormone biosynthesis 0 4 GO:0046931 pore complex biogenesis 0 4 GO:0048144 fibroblast proliferation 0 4 GO:0048281 inflorescence morphogenesis 0 4 GO:0048444 floral organ morphogenesis 0 4 GO:0048497 maintenance of floral organ identity 0 4 GO:0048499 synaptic vesicle membrane organization and biogenesis 0 4 GO:0048504 regulation of timing of organ formation 0 4 GO:0048509 regulation of meristem development 0 4 GO:0050673 epithelial cell proliferation 0 4 GO:0050767 regulation of neurogenesis 0 4 GO:0050828 regulation of liquid surface tension 0 4 GO:0050931 pigment cell differentiation 0 4 GO:0051092 activation of NF-kappaB transcription factor 0 4 GO:0051200 positive regulation of prosthetic group metabolism 0 4 GO:0051201 negative regulation of prosthetic group metabolism 0 4 GO:0051237 maintenance of RNA localization 0 4 GO:0051247 positive regulation of protein metabolism 0 4 GO:0007622 rhythmic behavior 0 5 GO:0009609 response to symbiotic bacteria 0 5 GO:0009909 regulation of flower development 0 5 GO:0031223 auditory behavior 0 5 GO:0035199 salt aversion 0 5 GO:0048070 regulation of developmental pigmentation 0 5 GO:0006124 ferredoxin metabolism 0 6