>Homo MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQQQ-PPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPP- -GPAV-AEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAME-LFLLCSDDAESDVRMVADECLNK VIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVP KIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILG VLLTLRYLVPLLQQQVKDTSLKGSFGVT---RKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPE LLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGG--------SSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVS SSALTASVKD-EISGELAASS-GVSTPG--------SAGHDIITEQPRS-QHTL-QA-DSVDLASC-DLT-----SSATD G------DEEDILSHSSSQVSAVPSDPAMDL-NDGT-Q-------------ASSPISDSSQTTTEGPDSAVTPSDSSEIV LDGTDNQYLGLQIGQPQD-EDEEA-TGILPDEASEAFRNSSMALQQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQE -NKP-CRIKGDIGQSTDDDSAPLVHCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVP L-DTT-EYPE--E-QYVSDILNYIDHGDPQVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLTGNTF---SLADCIPL LRKTLKDESSVTSKLACTAVRNCVMSLCSSSYSELGLQLIIDVLTLRNSSYWLVRTELLETLAEIDFRLVSFLEA--KAE NLHRGAHHYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKCDQGQA-DPVVAVARDQSSVYL--KLL MH----E-TQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLLSTAFPVCI WSLGWHCG-------------------------VPPLSAS----------DESRKSCTVGMATMILTLLSSAWFPLDLSA HQDALILAGNLLAASAPKSLR--SSWASEEE----ANP--AATKQ-E---EVWPALGDRALVPMVEQLFSHLLKVINICA HVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGE-QASVPLSPKKGSEASAASRQSDT--SGPVTTSKSSSLGSF YHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATV CVQQLLKTLFGTNLASQF---DGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQ---AEQE NDTSGWFDVLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQMH ID--SHEALGVLNTLFEILAPSSLRPVDMLLRSMFVTPNTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSFS -PYLISCTVIN--RLRDGD-STS--------TLEE-H-SEGKQIKNLPEETFSRFLLQLVGI----LLEDIVTKQLKVEM SEQQHTFYCQELGTLLM--CLIHIFKSGMFRRITAAATRLFRSDGC---GG-SFYTLDSLNLRARSMITTHPALVLLWCQ ILLLV-NHTDYRWWAEVQQTPKRHSLSSTKLLSPQMSGEEED--SDLAAKLGMCNREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHIQDLISLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCE--NLST-PTMLKKTLQCLEGIHL-SQSGAVLTL YVDRLLCTPFRVLARM-VDILACRR--VEMLLAANLQSSMAQLPMEELNRIQEYLQSSGLAQRHQRLYSLL-DRFRLSTM QDSLSPSPPVSS-HPLDGDGHVSLETVSPDKDWYVHLVKSQCWTRSDSALLEGAELVNRIPAEDMNAFMMNSEFNLSLLA PCLSLGMSEISGGQK-SALF-EAARE---------------VTLARVSGTVQQL-PAVHHVFQPE-LPAEPAAYWSKLND LFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKDIVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ LPGLWSVVSSTEFVTHACSLIY---------CVH---FILEAVAVQPGEQLLSPERRTNTPKAI---SEEEEEVD-PN-T QNPKYITAACEMVAEMVESLQSVLALGHKRNSGVPAFLTPLLRNIIISLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGT AFPEIPVEFLQEKEVFKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEE-SPPEEDTERTQINVLAVQAITSL VLSAMTVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSIIRGIVEQEIQAMVSKRENIATHHLYQ---AWDPVPSLSPA TTGALISHEKLLLQINPERELGSMSYKLGQVSIHSVWLGNSITPLREEEW-DEEEEEEA--------------------- -------DAPAPSSPP-TSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSSA-RRTP----AI--LISEVVRSLLVVSD LFTERNQFELMYVTLTELRRVHPSEDEILAQYLVPATCKAAAVLGMDKAVAEPVSRLLESTLRSSHLPSRVGALHGVLYV LECDLLDDT--AKQLIPVISDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLIENYPLDV-GPEFSASIIQMCGVMLSGS EEST-PSIIYHCALRGLERLLLSEQLSRLDAESLVKLSVD--RVNVHS-PHRAMAALGLMLTCMYTG------KEKVSPG -RTSDPNPA--APDS----ESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDIMNKVIGEFLSNQQPYP QFMATVVYKVFQTLHSTGQSSMVRDWVMLSLSNFTQRAPVAMATWSLSCFFVSASTSPWVAAILPHVISRMG--KLEQVD VNLFCLVATDFYRHQIEEELDRRAFQSVLEVVAA---PGSPYHRLLTCLRNVHKVTTC-- >Rattus MATLEKLMKAFESLKSFQQQQQQQQ-------------PPPQ-PPPPPPPPPQPPQPPPQGQ-----------PPPPPPL PGP---AEEPLHRPKKELSATKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAME-LFLLCSDDA-SRRRMVADECLNK VIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVP KIMASFGNFANDNEIKVLLKAFIANLKSSSPTVRRTAAGSAVSICQHSRRTQYFYNWLLNVLLGLLVPMEEDHPTLLILG VLLTLRCLVPLLQQQVKDTSLKGSFGVT---RKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPE LLQALTTPGGLGQLTLVREEAGGRGRSGSIVELLAGGG--------SSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVS SSAFAASVKS-EIGGELAASSSGVSTPG--------SVGHDIITEQPRS-QHTL-QA-DSVDLSGC-DLT-----SAATD G------DEEDILSHSSSQFSAVPSDPAMDL-NDGT-Q-------------ASSPISDSSQTTTEGPDSAVTPSDSSEIV LDGADSQYLGVQIGQPQE-EDREA-AGVLSGEVSDVFRNSSLALQQAHLLERMGHSRQPSDSSVDKFVSKDEVAEAGDPE -SKP-CRIKGDIGQPNDDDSAPLVHCVRLLSASFLLTGEKKALVPDRDVRVSVKALALSCIGAAVALHPESFFSKLYKVP L-STM-ESTE--E-QYVSDILNYIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGTIRALTGNTF---SLVDCIPL LQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLIDMLPLKNSSYWLVRTELLETLAEIDFRLVSFLEA--KAE SLHRGPHHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTRLVPKLFYKCDQGQA-DPVEAVARDQSSVYL--KLL MH----E-TQPPSHFSVSTITRIYRGYSLLPSVTDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCVLSAAFPVCT WSLGWHCG-------------------------VPPLSAS----------DESRKSCTVGMASMILTLLSSAWFPLDLSA IQDALILAGNLLAASAPKSLR--SSWASEEE----GSS--AATRQ-E---EIWPALGDRTLVPMVEQLFSHLLKVINICA HVLDDETPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGE-QTSTPMSPKKGGEASTASRQSDT--SGPVTASKSSSLGSF YHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATV CVQQLLKTLFGTNLASQF---DGLSSNPSKSQCRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQ---ADQE HDASGWFDVLQKVSAQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKPLSRQVADIILPMLAKQQMH ID--SHEALGVLNTLFEILAPSSLRPVDMLLRSMFITPSTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSFS -PYLISCPVIN--RLRDGD-SNP--------TLGE-R-SRGKQVKNLPEDTFSRFLLQLVGI----LLEDIVTKQLKVDM SEQQHTFYCQELGTLLM--CLIHIFKSGMFRRITAAATRLFTSDGC---EG-SFYTLDSLNARVRAMVPTHPALVLLWCQ ILLLI-NHTDHRWWAEVQQTPKRHSLSCTKSLNPQISAEE-D--SGSAAQLGMCNREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHIQDLISLSHEPPVQDFISAIHRNSAASGLFIQAIQSRCE--NLST-PTTLKKTLQCLEGIHL-SQSGAVLTL YVDRLLGTPFRALARM-VDTLACRR--VEMLLAANLQSSMAQLPEEELNRIQEHLQNTGLAQRHQRLYSLL-DRFRLSTV QDSLSPLPPVTS-HPLDGDGHTSLETVNPDKDWYLQLVRSQCWTRSDSALLEGAELVNRIPAEDMSDFMMSSEFNLSLFA PCLSLGMSEIAGSQK-SPLF-EAARR---------------VTLDRVTNVVQQL-PAVHQVFQPF-LPTEPTAYWSKLND LFGDTTSYQSLTTLARALAQYLVVLSKVPAPLHLPPEKEGHTVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ VPGLWGVLSSPEYVTHTCSLIH---------CVR---FILEAIAVQPGDQLLGPESRSHTPRAVRK--EE---VD-SD-I QNLSHITSACEMVADMVESLQSVLALGHKRNSTLPSFLTAVLKNIVVSLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGT VFPEIPVEFLQEKEVLKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEE-SPPEEDTERTQIHVLAVQAITSL VLSAMAVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSMIRGIVEQEIQEMVSQRENTATHHSHQ---AWDPVPSLLPA TTGALISHDKLLLQINSEREPGNMSYKLGQVSIHSVWLGNNITPLREEEW-DEEEEEEA--------------------- -------DAPAPTSPP-VSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSAA-RRTP----VI--LISEVVRSLLVVSD LFTDVPQFEMMYLTLTELRRVHPSEDEILIQYLVPATCKAAAVLGMDKTVAEPVSRLLESTLRSTHLPSQIGALHGILYV LECDLLDDT--VKQLIPVVSDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLMENYPLDV-GPEFSASVIQMCGVMLSGS EEST-PSVIYHCALRGLERLLLSEQLSRLDTESLVKLSVD--RVNVQS-PHRAMAALGLMLTCMYTG------KEKASPG -RASDPSPA--TPDS----ESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYP QFMATVVYKVFQTLHSAGQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCLLVSASTSPWVSAILPHVISRMG--KLEQVD VNLFCLVATDFYRHQIEEEFDRRAFQSVFEVVAA---PGSPYHRLLACLQNVHKVTAC-- >Mus MATLEKLMKAFESLKSFQQQQQQQ--------------PPPQPPPPPPPPPPQPPQPPPQGQ----------PPPPPPPL PGP---AEEPLHRPKKELSATKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAME-LFLLCSDDAESDVRMVADECLNK VIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVP KIMASFGNFANDNEIKVLLKAFIANLKSSSPTVRRTAAGSAVSICQHSRRTQYFYNWLLNVLLGLLVPMEEEHSTLLILG VLLTLRCLVPLLQQQVKDTSLKGSFGVT---RKEMEVSPSTEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPE LLQALTTPGGLGQLTLVQEEARGRGRSGSIVELLAGGG--------SSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVS SSAFAASVKS-EIGGELAASS-GVSTPG--------SVGHDIITEQPRS-QHTL-QA-DSVDLSGC-DLT-----SAATD G------DEEDILSHSSSQFSAVPSDPAMDL-NDGT-Q-------------ASSPISDSSQTTTEGPDSAVTPSDSSEIV LDGADSQYLGMQIGQPQE-DDEEGAAGVLSGEVSDVFRNSSLALQQAHLLERMGHSRQPSDSSIDKYVTRDEVAEASDPE -SKP-CRIKGDIGQPNDDDSAPLVHCVRLLSASFLLTGEKKALVPDRDVRVSVKALALSCIGAAVALHPESFFSRLYKVP L-NTT-ESTE--E-QYVSDILNYIDHGDPQVRGATAILCGTLVYSILSRSRLRVGEWLGNIRTLTGNTF---SLVDCIPL LQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLIDMLPLKNSSYWLVRTELLDTLAEIDFRLVSFLEA--KAE SLHRGAHHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATSLTRLVPKLFYKCDQGQA-DPVVAVARDQSSVYL--KLL MH----E-TQPPSHFSVSTITRIYRGYSLLPSITDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCLLSAAFPVCT WSLGWHCG-------------------------VPPLSAS----------DESRKSCTVGMASMILTLLSSAWFPLDLSA HQDALILAGNLLAASAPKSLR--SSWTSEEE----ANS--AATRQ-E---EIWPALGDRTLVPLVEQLFSHLLKVINICA HVLDDVTPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGE-QASTPMSPKKVGEASAASRQSDT--SGPVTASKSSSLGSF YHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATV CVQQLLKTLFGTNLASQF---DGLSSNPSKSQCRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQ---AEQE RDASGWFDVLQKVSAQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQVADIILPMLAKQQMH ID--SHEALGVLNTLFEILAPSSLRPVDMLLRSMFITPSTMASVSTVQLWISGILAILRVLISQSTEDIVLCRIQELSFS -PHLLSCPVIN--RLRGGG-GNV--------TLGE-C-SEGKQ-KSLPEDTFSRFLLQLVGI----LLEDIVTKQLKVDM SEQQHTFYCQELGTLLM--CLIHIFKSGMFRRITAAATRLFTSDGC---EG-SFYTLESLNARVRSMVPTHPALVLLWCQ ILLLI-NHTDHRWWAEVQQTPKRHSLSCTKSLNPQKSGEEED--SGSAAQLGMCNREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHIQDLISLSHEPPVQDFISAIHRNSAASGLFIQAIQSRCE--NLST-PTTLKKTLQCLEGIHL-SQSGAVLTL YVDRLLGTPFRALARM-VDTLACRR--VEMLLAANLQSSMAQLPEEELNRIQEHLQNSGLAQRHQRLYSLL-DRFRLSTV QDSLSPLPPVTS-HPLDGDGHTSLETVSPDKDWYLQLVRSQCWTRSDSALLEGAELVNRIPAEDMNDFMMSSEFNLSLLA PCLSLGMSEIANGQK-SPLF-EAARG---------------VILNRVTSVVQQL-PAVHQVFQPF-LPIEPTAYWNKLND LLGDTTSYQSLTILARALAQYLVVLSKVPAHLHLPPEKEGDTVKFVVMTVEALSWHLIHEQIPLSLDLQAGLDCCCLALQ VPGLWGVLSSPEYVTHACSLIH---------CVR---FILEAIAVQPGDQLLGPESRSHTPRAVRK--EE---VD-SD-I QNLSHVTSACEMVADMVESLQSVLALGHKRNSTLPSFLTAVLKNIVISLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGT VFPEIPVEFLQEKEILKEFIYRINTLGWTNRTQFEETWATLLGVLVTQPLVMEQEE-SPPEEDTERTQIHVLAVQAITSL VLSAMTVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSMIRGIVEQEIQEMVSQRENTATHHSHQ---AWDPVPSLLPA TTGALISHDKLLLQINPEREPGNMSYKLGQVSIHSVWLGNNITPLREEEW-DEEEEEES--------------------- -------DVPAPTSPP-VSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSAA-RRTP----VI--LISEVVRSLLVVSD LFTERTQFEMMYLTLTELRRVHPSEDEILIQYLVPATCKAAAVLGMDKTVAEPVSRLLESTLRSSHLPSQIGALHGILYV LECDLLDDT--AKQLIPVVSDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLMENYPLDV-GPEFSASVIQMCGVMLSGS EEST-PSIIYHCALRGLERLLLSEQLSRLDTESLVKLSVD--RVNVQS-PHRAMAALGLMLTCMYTG------KEKASPG -RASDPSPA--TPDS----ESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYP QFMATVVYKVFQTLHSAGQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCFLVSASTSPWVSAILPHVISRMG--KLEQVD VNLFCLVATDFYRHQIEEEFDRRAFQSVFEVVAA---PGSPYHRLLACLQNVHKVTTC-- >Sus MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQ-----------LPPPPPQPPQPPPQTQPPPQPPPPPPPPPPPPP- -GPAV-AEEPLHRPKKELSATKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAME-LFLLCSDDAESDVRMVADECLNK VIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVP KIMASFGNFANDNEIKVLLKAFVANLKSGSPTVRRTAAGAAVSVCQHSRRTRYFYSWLLSVLLGLLVPVEEEHGTLLILG VLLTLRYLVPLLQQQVKDTSLKGSFGVT---RKEMEVSPSTEQLVQVYELTLHYTQHQDHNVVTGALELLQQLLRTPPPE LLQALTSPGGIAQLTANNDEPRCRSRSGSIVELIAGGG--------SSCSPVLSRKQKGKVLLGDAAALEDEPASRSEGS SPALTASVTG-ELGGELAPSS-GVSTPGSA-SSAADSVGHDIITEQPRS-QHTL-QP-DSVDLSGC-DLS-----SAATD G------DEEDILSHSSSQMSAVPSDPAMDL-NDGT-Q-------------ASSPVSDSSQTTTEGPDSAVTPSDSSEIV LDGADGQYSGLRLGQPQDADADEDAAGLLPHGGPDAFRSSPTALQQSHVLKSLGHSRQPSDSSVDKFVSRDEAAEAGEPE -NKP-CRIKGDIGQSTDEDSAPLVHCVRLLSASFLLTGKRNALVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKAP L-DSV-EYPD--E-QYVSDILSYIHHGDPQVRGATAILCGTLVSSILSRSRFHVGDWMGAVRALTGNAF---SLVDCIPL LQKTLKDESSVTCKLACTAVRLCVAALCGSSYSQWGLQLITDLLTLRSSSYWLVRTELLETVAEIDFRLVSFLEA--KAE NLHRGAHHYTGLLRLQERVLNNVVIYLLGDEDPRVRHVAAASLVRLVPKLFYKCDQGQA-DPVVAVARDQSSVYL--KLL MH----E-TQPPSHFSVSTVTRTYRGYNLLPSVTDVTLENNLSRVTAAVSHELITSTTRALTFGCCEALCLLSTAFPVCV WSLGWHCG-------------------------VPPLGAA----------DESRKSCTVGMATTVLTLLSSAWFPLDLSA HQDALILAGNLLAASAPRSLR--SSWTLEEE----ASP--AATRQ-E---EVWPALGDRSLVPMVEQLFSHLLKVLNICA HVLDDVAPGPAVKAALPSLANPPSLSPIRRKGKEKEPGE-QASVPVSPKKGGEASPAARQSDT--SGPVAANKSSSLGSF CHLPSYLKLHDVLKATHANYKVTLDLQSGTEKFRGLLCSALDVLSQVLEVATLQDIGKCVEEILGYLKSCFSREPTMATV CVQQLLKTLFGTNLASQF---DGLASTPSKCQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNLVQ---AEQD HDASGWFDVLQKVSTQLKTNLTSVTKNRADKTALHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLVQYHQVLEMLILVLQQCHKESEDKWKRLSRQVADVILPMLARQQMH ID--SHDALGVLNTLFEVLAPSSLRPVDMLLRTMFLTPDSLAAVSTVQLWVSGILAILRVLISQSTEDIVLSRIQELSFS -PSLISCPMII--RLRGGN-SDS--------APEE-H-SEGRQGKNLPEETFSRFLLQLVGI----LLEDIVTKRLRVEV SEQQHTFYCQELGTLLM--CLIHIFKSGMFRRVTAAASRLLT-DGA---DG-AFFGLERLNAWVRAMVPTHPALVLLWCQ ILLLV-SHTDYRWWAEVQQTPRRRSLSSTKSLGPQMSGEDED--SDAASRLGMCSREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHIQDLIHLSHEPPVQDFISAVHRNAAASGLFIQAIQSRCE--NLSA-PTTLKKTLQCLEGIHL-SQSGAVLTL YVDKLLRTPFRVLARM-VDTLACRR--VEMLLAANLQSSMAQLPVEELTRIQEYLQSSGLAQRHQRLSSLL-DRLRLATA PGSRGPAPRVSS-HPLDGDGPLALETVSPDKDWYLRLVKSQCWTRSDSALLEGAELVSRIPPGDMGAFLMNPEFNLSLLA PCLGLGMREISAGQK-SPLF-EAARA---------------ATLDRVTSVVQQL-PAVHQVFQPF-LPTEPAAYWSKLDD LFGDAVLYRSLTTLARALAQYLLVLSKLPGPLQLPPEKEADTVRFVVMTLEALAWHLVHEQIPLSLDLQAGLDCCCLALQ LPGLWSALSSPEMVTHACSLIL---------CVR---FILEAIVVQPGDQLLSPERKADTPKAAG---EDE--VD-SN-T QSPPYLGAACRMVAEMVASLPSVLALGRERSSRTPAFLAPVLRNVIVSLARLPLVNSYTRVPPLVWKLGWSPRPGGDFGT AFPEIPVEFLQEKEVFREFIFRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEE-NPPEEDTERTQIHVLAVQAITSL VLSAMTVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSVIRGVVEQEVQAMVSKRENVATHHLYQ---AWDPVPSLSPA TTGALISHDRLLLQVNPERELGDTGYQLGQVSIHSVWLGNSITPLREEEW-DEEEEEEA--------------------- -------DVPVP-SPP-TSPLNSRKHRAGVDIHSCSQFLLELYSRWILPSSAA-RRTP----VI--LISEVVRSLLVVSD LFTERSQFEMMYLTLTELRRAHPPEDEILLQYLVPATCKAAAVLGMDKAVAEPVSRLLESTLRSSHLPSRIGALHGALYV LECDLLDDT--AKQLIPAISDYLLSNLRGVAHCVNVHSQQHVLVMCATAFYLIENYPLDV-GPEFSASVIQMCGVMLSGS EEST-PSIVYHCVLRGLERLLLSEQLSRLDAESLVKLSVD--RVNAHS-PHRAMAALGLMLTCMYTG------KEKISPG -RSSDPSPA--APDS----ESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYP QFMATVVYQVFQTLHSTGQSSMVRDWVMLSLSNFTQRTPVAMAVWSLSCFFVSASTSPWVSAILPHVVSRMG--KLEQVD VNLFCLVATDFYRHQIEEELDRRAFQSVFEVVAV---PGNPYHRLLTCLQDVHRVAAC-- >Gallus MATMEKLMKAFESLRSFQQQQ----------------------------------------------------------- -VPAAIPEEPTQRPKKELLTTKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAME-LFLLCSEDVESDVRMVADECLNK VIKALMDSNLPRLQLELYKEIKKNGASRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRISKRPEESVQETLAAAIP KIMAAFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYAWLLNVLLGLLVPVEDDHPTLLILG VLLTLRYLIPLLQQQVKDTSLKGSFGVT---RKETEISPSPEQLIQVYELTLHYTQHQDHNVVTGALELLQQLFRTPPPE LLHALTSLGGIAQVSVSKDESAIRSRSGSIVELIAGGG--------SSCSPVLARKHKGKILLGEEEGLEDDPETRSDVS AASFAASVKG-EITSELASSS-GVSTAGSVGSSAADPTGHDIITEQPRS-QHTL-QS-DSVDLSSC-DLT-----STATE G------EDDDVLSRSSSQISAVQSDPTMDL-NDGT-Q-------------ASSPISDSSQTTTEGPDSAVTPSDSSEIV LEGAEGQYSGMQIGQLQD-EEDEA-ANILQDDSSESFRSS-IALQQPHLLKTMSHSRQPSDSSVDRFPSKEDAVEPIDHE -NKP-SRVKGDIGHYTDGNSAPLVHCVRLLSASFLLTGEKGALVPDRDVRVSVKALAVSCVGAAVALHPESFFSKLYKMP L-EAMGEDYE--E-QYVSDILNYIDHGDPQIRGATAILCGTIINSILLKSRFDVEKWLVNVRSSTGNLF---SLVDCIPL LQKTLKDESSVTCKLACTAVRHCIMSLCSSSYSELGLQLIVDLLTLKNSSYWLVRTELLETLAEVDFRLVSFLEG--KTD SLHRGVHHYTGLLKIQERVLNDVVICLLGDEDPRVRHVAAASLMRLVPKLFYNCDQGQA-DPVVAVARDQSGVYL--KLL MH----E-TQPPSHFAVSTITRTYRGYNMLQNPTDVTMENNLSRVVAAISHALTISTTRSLTFGCCEALCLLSTTFPVCT WTVGWHCGYVLHPI-FMLLKLMHMKALGYQTFHVSQPSPS----------DDAQKGCTIGMAGMVLSLLSSTWFPLDLSA HQDALILTGNLLAASAPKCLK--NPWSAEED----SNQ--VAAKQ-E---EPWPALADRTLVTLVEQLFSHLLKVINICA HVMDDVAPGPAVKAALPSLTNPPSLSPIRRKGKEREPVE-QTSVPMSPKKGGETSP-GRHGDI--SGPAPTSKSSSVGSF YHLPSYLKLYDVLKATHANYKVTLDLQNSNEKFGCFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFNREPTMATV CVQQLLKTLFGTNLASQY---DGLSSNTSKAQGKAQRLGSSNLRPGLYHYCFMAPYTHFTQALADASLRNMVQ---AEQE HDASGWFDVLQKVSTQLKTNITSAAKHRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQRQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQMH ID--SHDALGVLNTLFEILAPSSLRPVDMLLRSMFVTPKTMASVSTVQLWISGILAILRVLISQSTEDIVLSRVQELSFS -PYLISRQAIN--RLRHGENNVS--------AQED-H-SEVKQTKYLPEETFSRFLLQLVGI----LLEDIVTKQVKVDM NEQQHTFYCQELGTLLM--CLIHIFKSGMFRRITAAATRLFTGDGS---DG-SFYTLESLSDLVQSMVPTHPSLVLLWCQ ILLLV-NYTNYNWWSEVHQTPKRHSLSTTKLLSPQISGDSDE--SDSESKRGMCNREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHVQDLINLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCE--NLAA-PTTLKKTLQCLEGIHL-SQSGAVLTL YVDKLLCTPFRVLARM-VDTLACRR--VEMLLAATLQNSITQLPVEELDRIQEYLQNSGLATRHQRLYSLL-DRFRLMVA PDTTSPSPLVTS-HPLDGEDQPGLENVILDKDWYMSLVRSQCCIKSDSALLEGAELLNRIPQPDLNSFMNSKEFNLSLLA PCLSLGMNEISRDQK-SSLF-EAARR---------------VTLDHLSATVLNL-PASHQVFQPL-LPTEPSAYWKKLND IFGDEVMYQSVMTLCRALAQYLLLLSKLPTSLRVPPDKEDDILKFVVMSIEALSWHLIHDRLPISIDLQAALDCCCLTLQ QPSLWNLLASAANVTYACSLIN---------CIK---FIIEAVAVEPGNQLLSPERKKN---ASKGLSEDE--VD-SN-M HKMKHITAACEMVAEMVECLQTVLALGHHRNSSIPAFLTPVLKNIIISLARLPLVNSYTRVPPLVWKLGWSPKPAGDFGT VFPEIPVEFLQEKEIFKEFIYRINTLGWISRTQFEETWATLLGVLVTQPIVMDQEE-NQQEEDTERTQINVLAVQAITSL VLSAMTIPVAGNPAVSCLEQQPRNKALKALDTRFGRKLSVIRGIVEQEIQAMVSKRDNIATHHLYQ---AWDPVPSLSPV STGALISHEKLLLQINTEREIGDMDYKLGQVSIHSIWLGNNITPLREEEW-GEDEEDEN--------------------- -------DVPVPSSPP-TSPINTRKHRAGVDIHSCSQFLLELYSQWILPSSP-NKRTP----VI--LISEVVRSLLAVSD LFTERNQFEMMYTTLTELRKVHPSEDEILIQYLIPATCKAAAVLGMDKAVAEPVSRLLESTLRSTHMPSRIGALHGILYI LECDLLDET--AKQLIPIISEYLLSNLRAVAHCVTVHNQQHILVMCAAAFYLIENYPLDV-GPEFSAGIIQMCGVMVSGS DEST-PSIIYHCVLRGLERLLLSEQLSRLDSESLVKLSVD--RVNVQS-PHRAMAALGLMLTCMYTG------KEKVSPS -RSTDANPA--APDS----ESVIVAMERVSVLFDRIRKGFPFEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYP QFMATVVYKVFQTLHTTGQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISAILPHIISRMG--KLEQVD VNIFCLVAMDFYRHQIDEELDRRAFQSVFEVVAS---PGTPYHRLLTCLQNVHKVTA--- >Xenopus MATMEKLMRAFESLKSFQQQQ----------------------------------------------------------- -VPVV-PEEPAPKAKKDPSTNKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAME-LFLLCSDDAESDVRMVADECLNK VVKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRISKRHEESVQETLAAAIP KIMAAFGNFANDNEIKVLLKAFIANLKSSSPAIRRTAAGSAVSICLHSRRTQYFYTWLLNVLLGLLIPVEDEHPTLLILG VLLTLRYLMPLLQQQVKDTSLKGSFGVT---QKEADISPSAEQLIQIYELTLHYTQHRDHNVVTGALELLQQIFRTPPLD LLHVLTTPGSIEQVSVCRDEPYSRSRSGSIVELIAGGS--------STCSPVIARKQKGKIHLGEEEGLDDDLEGKSDAP ATPFAAT-KN-EVPSDVTNLS--STAPGAN----LEGASHDIITEQPRS-QHTL-QS-DSVDISSS-DLA-----STVTE G------DEEDILSHSSSQISTVQSDTNMEL-NEGTTQ-------------ASSPVSDSSQTTTEGPDSAVTPSDSSEIV LDAAESQYSGMQIGQLQD-EEDEG-AILHQEEAGEHFGSSSLGLNQTHLLKTMGHSRQSSDSSVERFVPKEEPVDPGDLE -NKP-SRIKGDIGHYMDKDAAPLIHCVRLLSASFLLTGQKSVLVPDRDVRVSVKALAVSCVGAAVALLPESFFSKLYKLP T-ETT-ESQE--I-QYVSDILNYINHGDPQVRGATAILSGTIVFSVLSKAHFEAETWISKVKANTGNTF---SVQDCIPL LQKSLKDESSVTCKLACMAVRHCIMTLCCSTYSELGLQLIIDLLTLKNSSYWLVRTELLETLAEIDFRLVNFMEA--RTE NLHRGLHYYTGLLHLQDRVLNNVIISLLGDDDARVRHVAAASLARLVPKLFYNCDQVQA-DPVVAAARDQSSIYL--KLL MH----E-TQPPSHFAVSTITRIYRGYNIQQSPTDISMENNISKVITAVSHALTTSTTRALTFGCCEALCLLSITYPVCT WSIGWHCGYVTSTS-AQTSRIQVYKNRG-RSFSISQQSPS----------EEPRKSCTAGMSSMILSLLSSAWFPLDLSA HQDALVLVGNLLAATAPKSLK--NPWTSEEE----TSQ--GANKQ-E---EPWPALGDRAVVGMVDQLFIHLLKAINICA HVIDDITPGPVVK--------------------------------------------SRQTEA--SGPAQTSKS--IGSF YHLPSYLKLYDVLKATYANYKVSLDLQNNNEKFGGFLRSALDVLSQILELATLTDIAKCVEEILGYLKSCFSREPVMATV CVQQLLKTLFGTNLASQF---EAMSSNPSKCQGKAQRLGSSNLRPGLYHYCFMAPYTHFTQALADASLRNMVQ---ADQE QDTSGWFDVLQKVSSQLKNSISNVTKHRTDKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQRQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNVFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGANKADAGKELETQKEVVVSMLLRLIQYHQVI-------------------------------------MH ID--SHDALGVINTLFETLAPSALRPVDMLLRSMFVVPCTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSLS -PKLICCQNIM--NLREGDNPLPP------EVYPE-Q-SE--N-KPAPEETFSRFLLQLVGI----LLEDIVYKELKVDL SEQQHTFYCQQLGTLLM--CLIHIFKSGTFRRITNAAMRLFKGDGS---NG-SFYTLESLNGLVESMFPTHPSLVLLWCQ FLLLI-NYTNYSWWSEVHQTPKRNSLSSTKLLSPHMSTESDD--PDLTSKPGICNREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHVQDLINLSHEPPVQDFISAIHRNSAASGLFIQAIQSRCE--NLAA-PTSLKKTLQCLEGIHL-SQSGAVLLL YIDKLLCTPFRVLARM-VDTLACRR--VEMLLAATPQNSISQLPMEELDRMQEYLQSSGLAQRHQRLYSLL-DRFRMTVA PDTVSPLPSVTS-HPLDGENQATLETLDPDKEWYVSLVRSQCFTHSDSALLEGAELVNKIPAAERHSFMTSKNFNVSLLA PCLALGVHQISGEQD-SSFF-KTTLT---------------VIVDLLSGSVEQL-PAGHQVLQPL-QQVESTAYWEKLSL LFGDSSVYCSLVALCRALAQYLVSLPKLPAEFHIQQEKEVDFVKFMVLCVEAISWHLVHEQVPLSMDLQAVIDYCCLTLQ QPALWNLLASSEYVTHACSLIM---------CVR---FILEAVAVEPGDQLLSPERRKNK--MSED-SEED-QVD-SS-E QKHVFIKTACEMMAEMVESLQTILVFGHQKNRNFSAFLTPVFRNIIISLARLPLVNSYTRVPPLVWKLGWAPKWGGEFGT SLPEIPVEFLQEKEVFREFIYCINTLGWTSRTQFEETWATLLGVLVTQPMVMDQDE-NQQEEDTERTQINVLAVQAITSL VLSAMTITVAGNPAISFLEQQPRNKSLKALDTRFGRKLSVVRGIVEEEIQAMVSKRDNIATHHSCQ---AWDPVPSLSAP TTGTLINQERLLLQINTEREIGNMSYKLGQVSIHSVWLGNNITPLRQEEL-DEDEEDEN--------------------- -------ENPTPSSPP-MSPINSRKHRAGVDIHSCSQFLLELYSQWILPTNTG-KKTP----AI--LISEVVRSLLTVSD LFTERNQFEMMYTALTELQKQHPSEDEILNQYLVPAICKAAAVLGMDKVIAEPVSRIIETTLRSTHMPSRIGALHGILYI LECDLLDDT--AKQLIPVISDYLLSNLRGIAHCVNLHNQQHVLVMCATAFYLIENYPLDV-GPEFTSGIIQMCGVMVSGS EEST-PSMVYHCVMRGLERLLLSEQLSRLDGEALVKLSVD--RVNMHS-PHRAMTALGLMLTCMYTG------KEKISPG -RATEPSPA--APDS----ESVIVAMERVSVLFDRIRKGFPFEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYP QFMATVVYK--------GQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCFFVSASTSKWISAILPHVISRMG--KSEPVD VNLFCLVAIDFYKHQIDEELDRRSFQSVFELVAS---PGSPYYRLLLCLQNVHKITVF-- >Danio MATMEKLMKAFESLKSFQQQQ----------------------------------------------------------- -GPLS-AEELVQKQKKDLATTKKDRVTHCLTICENIVAQSLRTSPEFQKLLGIAME-MFLLCSDDKESDVRMVADECLNK IIKALMDSNLPRLQLELYKEIKKNAASRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRITKRQEETVQETLSSSIP KIMAALGHFANDGEIKMLLKAFVANLKSSSPTIRRTAASSAVSVCQHSRRTHYFYTWLLNVLLGLVVPVDEEHSSHLILG VLLTLRYLMPLIQQQTPSTSLKGSFGLV---RKEADVTPAPEQLIQVYELTLHYTQHWDHNVVTASLELLQQMFRTPPPE LLNVLITRGKITHTSVFREEMESRARSGSILELIAGG---------STCSPLLLRKQKGKLLSGEEEGLEDDPE-RAEVT TGSFTASVGG-DSSSE-APSSSGVSS----------LGTSDIITEQPRSSQHAL-QPGDSVDLSAS-EQG------VGPD TPDE--EDEEDMLSRSSSGGAGLVSTSG-DLVTDAN-Q------MSAGAV-SSSPPSESSQTTTEGPDSAVTPSDCAELV LDGSESQYSGMQIGTLQD-EEEEGSAPPP-DKPPEPFSQSALALSKPHLLEGKGHNRQSSDSSVDRFIPKEEVLEPAELD -NKP-SRIKGDIGHYTDPKEEPLMHCVRLLAASFLLTGQRNGLVPDNEVRVSVKALAVSCVGAAAALLPEAFFNLLYLQP L-DGQ-QT-E--EQQYISDILQYIEHGDHQIRGATAILCGALIQAIQLKTRYNTETWLSQIQSVTGSSV---TLENFVPL LQRSLKDESSVTCKMACAAVRHCIMALCNGSLSELGLQLLIDLLTLKNCSYWLVRTELLETLAEIDFRLISFLER--KTE KLHKGEHHYTGLLRLQDRVLNDVVLYLLGDEDPRVRHVAANTIGRLVPRLFFDCDQGQT-DPVVAIARDQSSVHL--QLL MH----E-TQPPSQFTVSTITRTYRGFNLCQSAPDVTVENNLSRVITAISHALTSSTSRAMTFGCCEALCLLSSTFPVCN WSTGWHCGFVSSSV-FHLNRSSQYRSRG-RSFSLSQSGSN----------EEVRRSLTVGVASMVLSLISSAWFPLDLSA HQAALLLAGNLLAAVAPKCMK--SPWAGEEE----SSP--ASSKV-E---EPWPALNDRSLVVMVEQLFSHLLKILNICA HVLDDTPPGPAVKASLPSLANTPSLSPIRRKGKEKDMME-AGTTPMSPKKGGETNT-GRAADS--TATAAVNKSTTLGSF YHLPPYLKLYDALRATHANYKVTLDLHNPNEKFGGFLRSALDVLSQLLELATLHDIGKCVEEILGYLKSCFSREPTMATV CVQQLLKALFGTNLASQY---EGASSNPCRSQGKALRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQ---AEQE QDASGWFDVMQKVSNQLRSSITNVTRHRGDKNAIHNHIRLFEPLVIKALKQYTTSTSVALQRQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRDSEEIVPNIFFFLVLLSYERYHSKQIISIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGSNKADAGKELETQKEVVVSMLLRLIQHHQVLEMFILVLQQCHKENEDKWKRLSRQVADIILPMIGKQQMH LD--SHEALGVLNTLFESVAPSSLRPVDMLLKSMFITPSTLASVGTVQLWVSGILAILRVLISQSTEDIILSRIQELSLS -PYLLSCPTIR--RLCDDDVPAPPETLP--VAMEDAN-GET--TRFPPEETFARFLLQLVGV----LLDDIANKQVKVDM SEQQHTFYCQQLGTLLM--CLIHIFKSGMFRRITAAGSKLLKAEGG---EGGDFYTLEGLNSLVLQLITTHPSLVLLWCQ VLLII-NYTNYTWWSEVHQTPRRHSLSSTKLLSPHSSGE-EE-RPEG--KLTMCNREIVRRGALILFCDYVCQNLHDSEH LTWLTVNHVSDLISLSHEPPVQDLISAVHRNSAASGLFIQAIQSRCD--NLCT-PVMLKKTLQCLEGIHL-SQSGALLML YVDKLLNTPFRVLARM-VDTLACRR--VEMLLAETLQNSIAQLPLEELDRIQQYLQTSGLAQRHQRFFSLL-DRFRATVA EDTTSPVAPITT-HPLDGDPPPPPENVEPNKEWYVTLVKSQCCLRGEGALYETTELLTKLPQSDLNAIMTCKDFNLCLLA SCLSVGVQRVCKDHG-AVLF-DTAQQ---------------VTFERLAGVIELL-PSPHQPLLPS-SKVCPD-YWQKLNQ VYGEPGFYQTVLSLCGVLSQYLLSLSKLPSSMHIPKDRETLITTFSTLAIEVVVWRLLQDQLPLSVDMQMSLSCLCLALQ QPAVWTHFTSHSYLTHTCSIIH---------CIQ---LLIHAVAVGPGDQFLRPERKISEQ------SED--QVD-SS-D NQR--EWHCCEIMAELVEGLQTVLTLGHHKNKNIPAFLTPTLRNVIISLARLPLVNSYTRIPPLVWKLGWSPKLSGEFGT ALPEIPVEFLQEKDVFREFLYRINTLGWSSRTQFEETWATLLGVLVTQPITMDQEEETQQEEDLERTQINVLAVQAITSL VLSAMTLPTAGNPAVSCPEQQPRNKILKALDTRFGRKLSVIRGMVEREIQAMVSKRDNIATHFPYQ---AWDPVPSLSSS TAGTLISHEKLLLQINTEREMGNMDYKLGQVSIHSVWLGNNITPLREEEW-GEDEEDEA--------------------- -------DAPAPASPQ-LSPINSRKHRAGVDIHSCSQFLLELYSQWILPGSPSSRKTP----VV--LISEVVRSLLAVSD LFTERNQFDMMFSTLTELQKVHPPEDEILNQYLVPAICKAAAVLGMDKAIAEPVCRLLESTLRSTHLPSRIGALHGVLYV LECDLLDDT--ARQLIPTVSEYLLSNLRAIAHCVNLHNQQHVLVMCAVAFYMMENYPLDV-GSEFNAGIIQLCCMILSAS EEAT-PSIIYHCVLRGLERLLLSEQLSRMDAETLVKLSVD--RVNMPS-PHRAMAALGLMLTCMYTGVAGEEGKEKGSPG -RPADADPT--APDS----ESVIVAMERVSVLFDRIRKGFPSEARVVARILPQFLDDLFPLQDVMNKVIGEFLSNQQPYP QFMATVVYKVFQTLHATGQSSMVRDWVLLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISALLPHVISRMG--KSDTVD ISLFCLVAMDFYRHQIDEELDRRAFQSVFEMVAS---PGSPYYQLLCCLQSIHQDTSL-- >Tetraodon MATMEKLMKAFESLKSFQQQQ----------------------------------------------------------- -GPPT-AEEIVQRQKKEQATTKKDRVTHCLTICENIVAQSLRMSPEFQKLLGIAME-TFLLCSDDSESDVRMVADECLNK IIKALMDSNLPRLQLELYKEIKKNGASRSLRAALWRFAELAHLIRPQKCRPYLVNLLPCLTRITKRQEETIQETLAAAMP KIMAALGHFANDGEIKVLLKSFVANLKSSSPTIRRTAASSAVSVCQHSRRTSYFYTWLLNVLLGLLVPVDEEHHSHLILG VLLTLRYLMPLLQQQVNTISLKGSFGVM---QKEADVQPSPEQLLQVYELTLHYTQHWDHNVVTAALELLQQTLRTPPPE LLHMLITAGSIQHASVFRQDAESRARSGSILELIAGGG--------ATCSPLLHRKHRGKMLSGEEDGLEDDPE-RAEVA TGSFTASVVGADNPSA-AQ--------------------VDIITEQPRS-SHTI-QPGDSVDLSASSEQGGGGGGTSASD TPESPNDNEEDMLSRSSSCGANLTPETADDATPESTTQEGGESGTLPGAGDHSLPPSDSSQTTTEGPDSAVTPSDVAELV LDGSESQYSGMQIGTLQD-EEEEGTAASSHEEAPEPFLRSALALSKPHLFESRGHNRQGSDGSVDCFTPKEEPPEP-EPD -NKL-SRIKGAIGHYTDRGVEPVVHCVRLLSASFLLTGQRSGLTPDKEVRVSVKALAVSCVGAAAALHPEAFFNSLYLEP L-DGL-PA-E--EQQYISDILGFIDHGDPQIRGATAILCAAIIQAALSKMRYNIHSWLASVQSTTGNPL---SLVDLVPL LRKALKDESSVTCKMACSALRHCIMSLCSSTLSELGLQLLVHLLALKDSSYWLVRTELLETLAEMDFRLVNFLER--KTE SLHKGDHHHTGRLQLQERVLNDVVISLLGDDDPRVRHVAAAAVSRLVSRLFFDCDQGQA-DPVVAIARDQSSVYL--QLL MH----E-TQPPSQLTVSTITRTYRGFNLSNNVADVTLENNLSRVVTAVSHAFTSSTSRALTFGCCEALCLLAANFPICT WTTGWHCGHVSSQSSF-SSRSSLSRSRG-RALSVSQSGSIPASSTTASALEPERRMLTIGMANMVLSLLSSAWFPLDLSA HQDALLLCGNLLAAVAPKCLR--NPWAGEDESSSSSTNTSGGTHKVE---EPWAALSDRAFVAMVEQLFSHLLKVLNICA HVLDDTPPGPPVKATLPSLTTTPSLSPIRRKGKEKDAVD-SSAAPLSPKKSSEANT-GRPTDS--AGSTAINKSTTLGSF YHLPPYLKLYDVLKATHANFKVMLDLHSTQEKFGSFLRAALDVLSQLLELATLNDINKCVEEILGYLKSCFSREPTMATV CVQQLLKTLFGTNLASQY---EGVLSGPSRSQGKALRLGSSSLRPGLYHYCFMAPYTHFTQALADASLRNMVQ---AEHE QDTSGWFDVMQKTSNLLRSNIANATRHRGDKNVIHNHIRLFEPLVIKALKQYTTSTSVALQRQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRQSEAIIPNIFFFLVLLSYERYHSKQIISIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGSNKADAGKELETQKEVVVSMLLRLVQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADVILPMIARQQMH LD--SPEALGVLNTLFETVAPSSLRPVDMLLKSMFTTPVTMASVATVQLWVSGILAILRVLVSQSTEDIVLSRIHELSLS -PHLLSCHTIK--RLRQQNLSPSDAPAC----NQEPN-GEA-Q-KSLPEETFARFLVQLVGV----LLDDISSRHVKVDI TEQQHTFYCQQLGTLLM--CLIHVFKSGMFRRITVAASRLLKAESGSGPSGAEFYPLEGLNSMVQCLITTHPPLVLLWCQ VLLII-DYTNYSWWAEVHQTPKGHSLSCTKLLSPHSSGEGEEEKPET--RLAMINREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHVRDLIDLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCE--NLNS-PTMLKKTLQCLEGIHL-SQSGSLLML YVDKLLSTPFRVLARM-VDTLACRR--VEMLLAETLQNSVAQLPLEELDRIQEYLQTSGLAQRHQRFYSLL-DRFRATV- SDTSSPSTPVTS-HPLDGDPPPAPELVDADKEWYVALVKSQCCVHGDVSLLETTELLTKLPPADLLSVMSCKEFNLRLLC PCLSLGVQRLVRGQG-SLLL-ETALH---------------VTLEQLAGATGLL-PVPHHSFLPT-SQ--PQLYWKQLAE VYGDPGFYSRVLSLCRALSQYLLTVNQLPSSLRIPSDKEHLITTFTCTAIEVVVWHLLQNQLPLSVDLQWALSCLCLALQ QPCVWNKLSTPEYNTHTCSLIY---------CLH---HIILAVAVKPGDQLLHPER--TKTNAVRH-SEEDE-VD-SV-Q NSHTFEWGACEIMAELVEGLQSVLSLGHHRNGAFPAFLTPTLRNIIVSLSRLPLVNSHTRVPPLVWKLGWSPQPGGEFGT TLPEIPVDFLQEKDVFREFLYRINTLGWSNRTQFEETWATLLGVLVTQPITMDQEEETQQEEDLERTQLNVLAVQAITSL VLSAMTLPTAGNPAVSCLEQQPRNKSLKALETRFGRKLAVIRGEVEREIQALVSKRDNVQTYHQYH---AWDPVPSLSAA SPGTLISHEKLLLQIQLERELGNMDYKLGQVSIHSVWLGNNINPLREEEW-GEDEDDET--------------------- -------DAPAATSPP-LSPTNSRKHRAGVDIHSCSQFLLELYSQWLIPGSPSNRKTP----TI--LISEVVRSLLAVSD LFTERNQFDMMFSTLMELQKLHPPEDEILNQYLVPAICKAAAVLGMDKAIAEPVCRLLETTLRSTHLPSRMGALHGVLYV LECDLLDDT--AKQLIPTVSEYLLSNLRAIAHCVNLHNQQHVLVMCAVAFYMMENYPLDV-GTEFMAGVIQLCGVMVSAS EDST-PSIIYHCVLRGLERLLLSEQLSRVDGEALVKLSVD--RVNMPS-PHRAMAALGLMLTCMYTG------KEKASPA SRPASSDPQ--VPDS----ESIIVAMERVSVLFDRIRKGLPSEARVVSRILPQFLDDFFPPQDVMNKVIGEFLSNQQPYP QFMATVVYKVFQTLHATGQSSMVRDWVLLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISALLPHVISRMG--SSDVVD VNLFCLVAMDFYRHQIDEELDRRAFQSVFETVAS---PGSPYFQLLACLQAIHQ------ >Fugu MATMEKLMKAFESLKSFQQQQ----------------------------------------------------------- -GPPT-AEEIVQRQKKEQATTKKDRVSHCLTICENIVAQSLRTSPEFQKLLGIAME-MFLLCSDDSESDVRMVADECLNR IIKALMDSNLPRLQLELYKEIKKNGASRSLRAALWRFAELAHLIRPQKCRPYLVNLLPCLTRITKRQEETIQETLAAAMP KIMAALGHFANDGEIKMLLKSFVANLKSSSPTIRRTAASSAVSVCQHSRRTSYFYTWLLNVLLGLLVPVDEEHHSHLILG VLLTLRYLMPLLQQQVNTISLKGSFGVM---QKEADVQPAPEQLLQVYELTLHYTQHWDHNVVTAALELLQQTLRTPPPE LLHVLITAGSIQHASVFRQDIESRARSGSILELIAGGG--------STCSPLLHRKHRGKMLSGEEDALEDDPE-KTDVT TGYFTA--VGADNSSA-AQ--------------------VDIITQQPRSSQHTI-QPGDSVDLSASSEQGGRGGGASASD TPESPN-DEEDMLSRSSSCGANITPETVEDATPENPAQE-GRPVGGSGAYDHSLPPSDSSQTTTEGPDSAVTPSDVAELV LDGSESQYSGMQIGTLQD-EEDEGTATSSQEDPPDPFLRSALALSKPHLFESRGHNRQGSDSSVDRFIPKDEPPEP-EPD -NKM-SRIKGAIGHYTDRGAEPVVHCVRLLSASFLLTGQKNGLTPDRDVRVSVKALAVSCVGAAAALHPEAFFNSLYLEP L-DGL-RA-E--EQQYISDVLGFIDHGDPQIRGATAILCAAIIQAALSKMRYNIHSWLASVQSKTGNPL---SLVDLVPL LQKALKDESSVTCKMACSAVRHCIMSLCGSTLSELGLRLVVDLFALKDSSYWLVRTELLETLAEMDFRLVNFLER--KSE ALHKGEHHYTGRLRLQERVLNDVVIQLLGDDDPRVRHVAASAVSRLVSRLFFDCDQGQA-DPVVAIARDQSSVYL--QLL MH----E-TQPPSQLTVSTITRTYRGFNLSNNVADVTVENNLSRVVTAVSHAFTSSTSRALTFGCCEALCLLAVHFPICT WTTGWHCGHISSQSSF-SSRVG--RSRG-RTLSVSQSGSTPASSTTSSAVDPERRTLTVGTANMVLSLLSSAWFPLDLSA HQDALLLCGNLLAAVAPKCLR--NPWAGEDDSSSSSTNTSGGTHKME---EPWAALSDRAFVAMVEQLFSHLLKVLNICA HVLDDTPPGPPVKATLPSLTNTPSLSPIRRKGKDKDAVD-SSSAPLSPKKGNEANT-GRPTES--TGSTAVHKSTTLGSF YHLPPYLKLYDVLKATHANFKVMLDLHSNQEKFGSFLRAALDVLSQLLELATLNDINKCVEEILGYLKSCFSREPTMATV CVQQLLKTLFGTNLASQY---EGFLSGPSRSQGKALRLGSSSLRPGLYHYCFMAPYTHFTQALADASLRNMVQ---AEHE QDTSGWFDVMQKTSNQLRSNIANAARHRGDKNAIHNHIRLFEPLVIKALKQYTTSTSVALQRQVLDLLAQLVQLRVNYCL LDSDQVFIGFVLKQFEYIEVGQFRDSEAIIPNIFFFLVLLSYERYHSKQIISIPKIIQLCDGIMASGRKAVTHAIPALQP IVHDLFVLRGSNKADAGKELETQKEVVVSMLLRLVQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADVILPMIAKQQMH LD--SPEALGVLNTLFETVAPSSLRPVDMLLKSMFTTPVTMASVATVQLWVSGILAVLRVLVSQSTEDIVLSRIHELSLS -PHLLSCHTIK--RLQQPNLSPSDQPAGDGQQNQEPN-GEA-Q-KSLPEETFARFLIQLVGV----LLDDISSRHVKVDI TEQQHTFYCQQLGTLLM--CLIHVFKSGMFRRITVAASRLLKGESGSGHSGIEFYPLEGLNSMVHCLITTHPSLVLLWCQ VLLII-DYTNYSWWTEVHQTPKGHSLSCTKLLSPHSSGEGEE-KPET--RLAMINREIVRRGALILFCDYVCQNLHDSEH LTWLIVNHVRDLIDLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCD--NLNS-PTMLKKTLQCLEGIHL-SQSGSLLML YVDKLLSTPFRVLARM-VDTLACRR--VEMLLAETLQNSVAQLPLEELHRIQEYLQTSGLAQRHQRFYSLL-DRFRATV- SDTSSPSTPVTS-HPLDGDPPPAPELVIADKEWYVALVKSQCCLHGDVSLLETTELLTKLPPADLLSVMSCKEFNLSLLC PCLSLGVQRLLRGQG-SLLL-ETALQ---------------VTLEQLAGATGLL-PVPHHSFIPT-SH--PQSHWKQLAE VYGDPGFYSRVLSLCRALSQYLLTVKQLPSSLRIPSDKEHLITTFTCAATEVVVWHLLQDQLPLSVDLQWALSCLCLALQ QPCVWNKLSTPEYNTHTCSLIY---------CLH---HIILAVAVSPGDQLLHPERKKTK--ALRH-SDDEDQVD-SV-H DNHTLEWQACEIMAELVEGLQSVLSLGHHRNTAFPAFLTPTLRNIIISLSRLPLVNSHTRVPPLVWKLGWSPQPGGEFGT TLPEIPVDFLQEKDVFREFLYRINTLGWSNRTQFEETWATLLGVLVTQPITMDQEEETQQEEDLERTQLNVLAVQAITSL VLSAMTLPTAGNPAVSCLEQQPRNKSLKALETRFGRKLAVIRGEVEREIQALVSKRDNVHTYHPYH---AWDPVPSLSAA SPGTLISHEKLLLQINTERELGNMDYKLGQVSIHSVWLGNNITPLREEEW-GEDEDDEA--------------------- -------DPPAPTSPP-LSPINSRKHRAGVDIHSCSQFLLELYSQWVIPGSPSNRKTP----TI--LISEVVRSLLAVSD LFTERNQFDMMFSTLMELQKLHPPEDEILNQYLVPAICKAAAVLGMDKAIAEPVCRLLETTLRSTHLPSRMGALHGVLYV LECDLLDDT--AKQLIPTVSEYLLSNLRAIAHCVNLHNQQHVLVMCAVAFYMMENYPLDV-GTEFMAGIIQLCGVMVSAS EDST-PSIIYHCVLRGLERLLLSEQLSRVDGEALVKLSVD--RVNMPS-PHRAMAALGLMLTCMYTG------KEKASPA ARSAHSDPQ--VPDS----ESIIVAMERVSVLFDRIRKGLPSEARVVARILPQFLDDFFPPQDIMNKVIGEFLSNQQPYP QFMATVVYKVFQTLHATGQSSMVRDWVLLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISALLPHVISRMG--SSDVVD VNLFCLVAMDFYRHQIDEELDRRAFQSVFETVAS---PGSPYFQLLACLQSIHQDKSL-- >C_intestinalis ---MEKLVKSVNALKFFY-------------------------------------------------------------- -GGLS-SED--QTQK-DALQSPNERQSHCNIVLESIISPSIRSLADYPGLLAVSVETLLQSCADD-NADVRLNANECLNR LIKGLYEISNSKILVELYKEIKKNGHPRSLRAALDRFSRLSHNIRSNKCRPYILNLLPCLCRISQREEDGVQETLGLSLV KIFKILGPFASESEIQGLLASFLKNLSHKSATMRRTACVCLHSVILNCRKQNLVIGPLMNSILDILLQRNTDRNT--VLG CLQALRILSPLF---ETCVPGKISEQHILNEHRDL--------VLKVFDACVFYLDNTDHTIVTAALELLEHLLNEFSSE LASVLIVCGKL-KPTSF-------TPSTVLPDEVETKATSVTTDEVSSLSSLASSTIEDKLSCIRLLPVED----QDPPS NP------------------------------------------LLPHNEQTSQTNGATE-------------------- ------------------------------------------------HKDQTEP-SDLDQTITNHD----------EDA -----------------------------------------------KLPE-NGHEESLSESSLEKMA-SDPISTSSD-- -LIPVSHLYATESSTLPIITLARMLCQR-----FLLSMETGEVLPDKQVRVSNKNLTMNTLSQLVKIYPAAVCH-----S L-LYY----E-SSSQYMTNVFLYSTHSDPKLRGSAVTLTSVFIDAVVTRNRKGIKDWFKNVERNSSTSLKCPTIEDLISL IHGGLIDESSTTTRQACSAVTSCVHTLLNSMLFSYGLELLHMVVGLQSSTYWLIKVSLLELLASLNYRQIAYLELLTKRD AAS--VK--TQSLSHQ--ALSIALKCLC-DDDLRLRKTAAATIVTMPTS--FPTPNELYGDLLTSEAAEMTRQWMGG-SE MRNEDEE-EQSNDAGSAKSLLKTYRGYEMDCKNSGSITDS-LSYIVGEVSTMLTNSSNKHQTYGCLLALKQLSIKYMVSN HPVAWGCYAVTDDR----SRSS---SN--ESETSSNSSDSKIPKRQSSNPNGSQQQ--FGILPFVMSLLHSAWLPLDVTA HSDALVLAGNLVAGAASDGSKVFGPVAIED-----QSFEKVSVKTVTSNARSWATIYDPVLGSYANQLFTHLTRLSSIMH HVISEVTPSPPNKSVLPNIAPGNIPSPIKRK--EKAPGEQNRSSPPLTRKLLPTSSLGKPGN-KENQDEKPTKK-LIGSF YNNRTLMRLFDQLTGSYKNYKGSLEFG-CDDRFCSFLSSTLDVLSQVLELAVFQDIGSYTEELLNYMKSLFTVEPTLTIQ SVQQLLKALFGTNLVSNMIPHDDSK-PPNPPTSPILL-NSTA---GFYHQIFHHPLNHLTMAIANSSFHHSLQTKSPPKE ND--GWFGSIKKK-VEKKLNDVS-KNSKGSKSSIQNYIRLFEILVIKSLKLYTTTSSVEFQKHVLNLLAQLVQLRVNYCM LDSDQVFINFIIKQFESIEGGLVRGSESLIPHVFFFLVLLSYERYRTKAVITMPKIIQLCDGLMASGQGSASHVIPAMQP IIHDIYVVRASSKNEP-PEVTTQREVVQFTLLKLLQHPQVFKMLITILVHGRRENVEKWKKYSRQVADVLLPLLSQLK-- VEVTSHDDVSTLHSLFEAISPSALRPIGLLMDLLLKMPKSLNSISHIHRWLTNILVLLRVLICQASEHDILDNI-DLSKV KIKHMTCTHMEYLHS-DQ-TSQE----------EEQHMNE----VFSPADILAIFFHQVIGSCCSTLLHYSTNPRTKSDE SSQI--LLSQQINELFLALTYIH--RSGSFKNLTSACKKVSSTNI----NG--FYTSDQMVSTFLHLTYSHPIITVMWAQ YLSHFVPVTAQ-FW-E-NFTG-CK---------------------DT--KDFPLNRNIVKRGCVILLADYVCQNSNQSEL SLWLAEHHVNDIIMMSEEPPVQDFLTSVHLGAEESACLIKAI-SKLSKTQQNIKASFILRILKCLSGVSIKSSESLISLL LSPKFLFSPVR---RVFAASLLFLQTTVENILELNKEEALEIIPT-EFT--QNLMQK-GESLKEKSQYILFCDLISQL-- HSHVTGEQPITSEKPG-PTIQALME--KPNQNWFNSVILS-C-LDENKWSPECARVLACADFDDIIDIQGNNNFTAQHLA SCLYIGIHEVTSIHAPLIPYPEDKTSNLLAASLLTLDKKIKAVLEITPGNTEFDTPL-KDN-SNSEIKFIGDENF-QQNL MWLN----RCLVNMLKFH-------HILPTQYQLPNVNSNDYLNIIVLGFKVTQYGIHRGKIP-S--LQDIV-CVLESLQ Q-ALAVQ---SL-----HAMFINE-VKWMLQTVQVLFTIMEIYIGRISYE--PPYLP----------SCID-KEEASSIY NNSSNPLSSCIKLYQMLSLFRR-QHQNREKFAKIPTYIVRPINNIILHLATSPLFKDYVRTPLVVWTFGWNPALGGDTGT SLPEIPSDFLQEKEVLQEYIAIVNQIGWTKRTEFEETWASLLGVLVSQPVVSD-E--SSGE--AMHTEISSLAIRGLTSL VVDCALYPECGRKATSKYQVFYRHPTFKLGNTKAGRQLLKVRGILDDESRFMTHRKSHQDTHH-QN-TSLND---SSNLS S--SLQSNKW--ITMNTERVLSSSAYGLAQSSVRSFHLLHGITPMKEESYDGDYDSATMHSFEYDNSLSNDGSDVSDMFE TSEAETPDVPTNPAPP-LSPL--R-IRDGVDVHSCVQFLLELYTEWFRTTAQTNQISGSSSTIARPLLCECVRSLLLISD LFTEKQQFEWMFVALTTLHNAQPADDDVLMQYITPSMCKAGSVLGLNSETSENVLRVLEPSLSSTLLSCRTSALVGLL-- -QCIESYPNPNLRGIIDLASQFIPPNFVAISTCPSLFNEDYVVLLASVAFYIIEKCH-DAVMPEFTSVIIQACTLIISSR DVTSVQSRVFHSVTHGLQRLILSFSISASECDSILKVAAEQVHTN-PWLP-RATAACGLMMTCMYCG------RMRISS- -NPDHGSPHGGSPEHEDVVESRLLAMERVTLLFERIRKGYPHEARVMSKVLPSMLDDFFPAQDIMNKIIAEFISTLQPFP ASVAQILYEVFQSLLERDQSHLVQEWVMLSLGNAIQRTPLQTAVWCLTCLFSSASTNRWISSMVPLIISRVHDPTLD-VD WTCFCKAAVDFYTCQLSEELDRRSFHAIFSTSSSSREPGSPYKLLLDCISRINGEQGILQ >C_savignyi ---MEKLVKSVNALKFFH-------------------------------------------------------------- -GGLS-SED--KTQK-DSLQSPTERQNHCNIITDSIISQSIRSLVDFPGLLAVSVETLLQSCADE-NADVRLNSNECLNR VIKGLYDVSVSKILVELYKEIKKNGHARSLRAALKRFSYLSPNIRSNKCRPYILNLLPCLCRISQREEDAVQEVLSSSLA KIFIVLGAFASESEIQGLLASFLKNLSHKSPTVRRTACICLHSILTNSRKKNVVIGPLVHSIIDILLQRSTDRNT--VLG CLQALRILNPLF---EITVQGKITDNQVLKQHKDL--------ILKAFDACIFYLDNTDHTIVTATLELLDNLLSGFPSE LSAVLTKVGAL-NETSF-------TPSATKMDIVQDK--SVTPDEVSSLSSLASSTIEEKISGIRLVPLEDT---KTNQD DP------------------------------------------LLPHNDNSAVKNTTAL-------------------- ------------------------------------------------ETLQTNA-VDGETSSKTDVVHGEASSKT-ELN -----------------------------------------------IQTD-NVIVE--SELNDDKSA--DGVVTQTETS KLLPISDLYG-NSKQLPIVTLTRLLCQR-----FLVNIDTGELLPDKQVRVSNKNLAMNTLSQIIKIYPSAICY-----P IQDSV-N--EVSEVHYMTNVLQCSKHSDPKLRGSSITLASFLIDAVVTTHRCGFESWIRNVEKSTISTLNCPTIDELSLL IRDGLIDESSTTSRQACSAVTSCVNTLLNSECFTYGLHLLHCSMELHTSTYWLIKVGLLELLASINYRQVVYLESLTS-E NSTQ-IK---QKSIAQ-KALSIALECLC-DEDTRLRKTSSAAIVSMATS--YPTPNDD--DLLTSEAVEKSRKWMGGAAE VKVDEEDVERSSDAGSPKSLLKTYRGYEIDGSNSGSIADS-LSYIVGEVSTLLTNSWNKHQAFGCILALKELSMKYTVAS YPTAWGCFLVDDER----LRTA---SN--ESGNSSQSTDSKSGTKQSSN-SAAQQQ--FGILPIVMSLLRSAWLPLDVTA HSDALVLAGNLIAGASSNDLKLYGPVPIED-----QSFEKVSSKTLPSADRNWATLHDTVLGSYANQLFTHLTKLTSIMH HVISDITPSPPNKSVLPNIAPSAIPSPMKRR--EKPSNEPNKPSPPLTRKLLPSSPLTKPGFTKESQEEKPSKK-LIGSF HTNRVLMKLHEQLAGSYRNYKGSLDFG-ADDRFCSFMSGVLDVQSQMLELAVFQDIGSYTEEILSYMKSLFTIDPTLTIQ SVQQLLKALFGTNLVSNLVPHDETHQPPKSPSSPLAAPNTS----GFYHQIFHHPLNHLTMAIANSSFHHSLQSKSPVKD ND--GWFGSIKKK-VERKLNDVS-KNSKSNKSSIQNYIRLFESLVIKSLKLYTVTSSVEFQKHVLNLLAQLVQLRVNYCM LDSDQVFINFIIKQFESIEGGMVRGSESLIPHVFFFLVLLSYERYHSKSVITMSKIIQLCDGLMASEQGSASHVIPAMQP ITHDIFVVRGSLKNEP-PEVTTQREVVQFMMLKLLQHPQVYKMMITILMHCRRDNMEKWKKYSRQVADVVLPMLGQLK-- IEVTCHDDISTLHSLFEALSPTALRPISLLKDLLLRIPKSLVSISHMHRWLASVLVLLRVLICQAREQDILDNV-DVNKV KVQTMTCSLFE--HLQSG-SYPT----------EEAKETD----KLPSAETLAIFFHQLIGSSCSYLLQFGSNPSTKSDE SSQI--LLSQQINELLLSLTYIH--RSGSFKIFTAACKKLSESSN----EN--FFSHGQMAKMFESLSHVHPMLTVMWAQ YLSYFMPVQTE-FW-K-RFT--CK---------------------ETS-HFA-LNRNLVKTGCLILLADYTCQNSNQHHL SLWLTENHVYDITMMRDEPPVQDFISSLHQDATESKCFVEAL-SKHLGTHQKFKPSFALRILHCLTGVSTKSSQALISLL LSPKFVLSPVR---TVFAASQQLLQTTVENVLKLSREDAVEIINT-EFA--QNLVVQ-VENIKKKPQYRTVCHLIGQL-- HDHVTGNQPITTQKPN-VNIQLLLE--KPNKEWFKYVVLS-C-LQENHWSPECAGVLAHVDEDDITEIQSHPSFTLQHLT SCIHNGIHEVTSVHGALTPYPEDKTSALLAASLTTLLGKMIEVLENSNGNTVSQ-PS-HDKATENETNVFDDVNF-NDDL MWLN----ESLVLMYRHH-------PMLPTQYQLPTEHYKHYLTVSMLGLQAIGYQINSGEVP-S--LQKTM-CALESLQ Q-ALFVK---PI-----CSMLINEEFKWLKDCVRIVFNILQMYIGKVPYT--PPYLP----------SDYD-KEVTSSIY NDASNPLSSCIKLSQMLAFFRS-PHENGQMFREIPSCVMRPLNNILLHLATAPLFKDYIRAPPIVWKYGWNPPLGGDSGT SLPEIPSDFLQEKEVLQEYISIVNQMGWTKRAEFEETWTTLLGVLVSQPVVPD-D--SSSE--SMRSEISSLAIRGLTSL VVDCALHPDCGRKATSKFQVYHRHSAFKLAHTKVGRQLLKVRGILEDESWTMTKQKTNQDTHH-NQHVTQNE---TSS-- ----SYSHEW--ISTNMERILSPSTYGLAQNSVRSFHVLHGITPVKEDFYDGDYDSAS------DNSLSNDGSDVSDMFD TSGPDTPLTPANPQPPPLSPL--R-IRDGVDVHSCVQFLLELYTEWFRTAAQANQNSPS---VARPLLCECVRSLLLISD LFTEKHQFEWMLTALTTLQNSQPLDDDVLMQYLTPAICKAASVLGMTSEMAENVLRVLEPSLSSTLLSCRTSALVGLL-- -QCIETHPSPNLRPIVDLGSQFIPPNFVAVSSCPSLFNEEYVVLLATVAFYLIEKCH-DAVMPEFTAVVIQASLLIISSR DDTSVPNRVFHAVVHGLQRLVLSFSLSAPECDSILKVAAEHLHTN-PWMS-RATAVCGLMMTCMYCG------RMRISS- -NPDHPSTQGGSPEHEDAVETRLLAMERVSLLFDRIRKGYPQEARVMSKILPSMLDDFFPAQEIMNKIIAEFISTLQPFP GSVAHILYEVFQSLHERDQSHLVQGWVMLSLGNAIQRTPLHTAVWCLTCLFASASTNRWISSMVPLIISRSHDPSLD-RN WTCFCKSAVDFYTCQLSEELDRRSFHAIFSTSSSSGDPASPYQLLLDSISRINGEQGILQ