{"text_format":"3","workbook":"xls","n_sheets":5,"sheets":["GPRs","Reactions not associated to gen","Exchange_fluxes","Metab Abbr","Dead End Metab"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"GPRs","index":0,"n_rows":300,"n_cols":15,"rows_kept":300,"flags":["formulas_cached_only"]}
["Abbreviation","Official Name","Bge number","Isoenymes or Enzyme complexes","E. coli gene name","Bge Name ","Equation (note [c] and [e] at the beginning refer to the compartment the reaction takes place in the cytoplasm and extracellular environment, respectively)","Subsystem","ProteinClassDescription","Cofactors"]
["R_4HTHRS","4-Hydroxy-L-threonine synthase","BLBBGE_499",null,"thrC","threonine synthase ","[c] : h2o + phthr → 4hthr + pi","Cofactor and Prosthetic Group Biosynthesis","EC:3.1.3.11"]
["R_ACCOACr","acetyl-CoA carboxylase, reversible reaction","BLBBGE_154, BLBBGE_477, BLBBGE_516, BLBBGE_517","Enzyme complex","accA, accD, accB, accC","acetyl-CoA carboxylase subunit alpha; acetyl-CoA carboxylase subunit beta; acetyl-CoA carboxylase, biotin carboxyl carrier protein; biotin carboxylase ","[c] : accoa + atp + hco3 → adp + h + malcoa + pi","Membrane Lipid Metabolism","accA, accB and accD, EC:6.4.1.2; accC, EC:6.3.4.14"]
["R_ACGK","acetylglutamate kinase","BLBBGE_319",null,"argB","acetylglutamate kinase","[c] : acglu + atp → acg5p + adp","Arginine and Proline Metabolism","EC:2.7.2.8","Mg2+"]
["R_ACHBS","2-aceto-2-hydroxybutanoate synthase","BLBBGE_555, BLBBGE_556","Enzyme complex","ilvH, ilvI","acetolactate synthase I/III small subunit, acetolactate synthase large subunit","[c] : 2obut + h + pyr → 2ahbut + co2","Valine, Leucine, and Isoleucine Metabolism","EC:2.2.1.6","Mg2+"]
["R_ACLS","acetolactate synthase","BLBBGE_555, BLBBGE_556","Enzyme complex","ilvH, ilvI","acetolactate synthase I/III small subunit, acetolactate synthase large subunit","[c] : h + (2) pyr → alac-S + co2","Valine, Leucine, and Isoleucine Metabolism","EC:2.2.1.6","Mg2+, FAD"]
["R_ACOATA","Acetyl-CoA ACP transacylase","BLBBGE_111",null,"fabH","beta-ketoacyl-acyl-carrier-protein synthase III","[c] : ACP + accoa → acACP + coa","Membrane Lipid Metabolism","EC:2.3.1.41"]
["R_ACODA","acetylornithine deacetylase","BLBBGE_320",null,"argE","bifunctional peptidase/acetylornithine deacetylase","[c] : acorn + h2o → ac + orn","Arginine and Proline Metabolism","EC:3.5.1.16","Zn2+"]
["R_ACONT","aconitase","BLBBGE_017",null,"acnA","aconitate hydratase","[c] : cit ↔ icit","TCA cycle ","EC:4.2.1.3"]
["R_ACOTA","acetylornithine transaminase","BLBBGE_315, BLBBGE_623","isoenzymes","argD","acetylornithine transaminase (BLBBGE_315); bifunctional acetylornithine transaminase/N-succinyldiaminopimelate aminotransferase (BLBBGE_623)","[c] : acg5sa + glu-L ↔ acorn + akg","Arginine and Proline Metabolism","EC:2.6.1.11"]
["R_ACPS1","Acyl-carrier protein synthase","BLBBGE_379",null,"acpT","putative 4'-phosphopantetheinyl transferase superfamily protein","[c] : apoACP + coa → ACP + h + pap","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.8.7"]
["R_ADCL","4-aminobenzoate synthase","BLBBGE_455",null,"ilvE","branched-chain amino acid transaminase","[c] : 4adcho ↔ 4abz + h + pyr","Cofactor and Prosthetic Group Biosynthesis","EC:4.1.3.38"]
["R_ADCS","4-amino-4-deoxychorismate synthase","BLBBGE_421, BLBBGE_422","Enzyme complex","trpE, trpD","anthranilate synthase component I, anthranilate synthase component II","[c] : chor + gln-L → 4adcho + glu-L","Cofactor and Prosthetic Group Biosynthesis","EC:6.3.5.8","Mg2+"]
["R_ADK1","adenylate kinase","BLBBGE_215",null,"adk, plsA, dnaW","adenylate kinase","[c] : amp + atp ↔ (2) adp","Nucleotide Salvage Pathway","EC:2.7.4.3","Mg2+"]
["R_ADK3","adentylate kinase (GTP)","BLBBGE_215",null,"adk, plsA, dnaW","adenylate kinase","[c] : amp + gtp ↔ adp + gdp","Nucleotide Salvage Pathway","EC:2.7.4.3","Mg2+"]
["R_ADK4","adentylate kinase (ITP)","BLBBGE_215",null,"adk, plsA, dnaW","adenylate kinase","[c] : amp + itp ↔ adp + idp","Nucleotide Salvage Pathway","EC:2.7.4.3","Mg2+"]
["R_ADNK1","adenosine kinase","BLBBGE_215",null,"adk, plsA, dnaW","adenylate kinase","[c] : adn + atp  ↔ adp + amp + h","Nucleotide Salvage Pathway","EC:2.7.4.3","Mg2+"]
["R_ADSK","adenylyl-sulfate kinase","BLBBGE_275",null,"cysN (acting here as cysC)","phosphosulfate kinase","[c] : aps + atp -> adp + h + paps","Cysteine Metabolism","EC:2.7.1.25","Mg2+"]
["R_ADSL1r","adenylsuccinate lyase","BLBBGE_487",null,"purB","adenylosuccinate lyase","[c] : dcamp → amp + fum","Purine and Pyrimidine Biosynthesis","EC:4.3.2.2"]
["R_ADSL2r","adenylosuccinate lyase","BLBBGE_487",null,"purB","adenylosuccinate lyase","[c] : 25aics → aicar + fum","Purine and Pyrimidine Biosynthesis","EC:4.3.2.2"]
["R_ADSS","adenylosuccinate synthase","BLBBGE_488",null,"purA","adenylosuccinate synthase","[c] : asp-L + gtp + imp → dcamp + gdp + (2) h + pi","Purine and Pyrimidine Biosynthesis","EC:6.3.4.4","Mg2+"]
["R_AGMT","agmatinase","BLBBGE_059",null,"speB (also functions as rocF)","agmatinase","[c] : agm + h2o → ptrc + urea","Arginine and Proline Metabolism","EC:3.5.3.11","Mn2+ "]
["R_AGPR","N-acetyl-g-glutamyl-phosphate reductase","BLBBGE_314",null,"argC","N-acetyl-gamma-glutamyl-phosphate reductase","[c] : acg5p + h + nadph ↔ acg5sa + nadp + pi ","Arginine and Proline Metabolism","EC:1.2.1.38"]
["R_AICART","phosphoribosylaminoimidazolecarboxamide formyltransferase","BLBBGE_480",null,"purH","phosphoribosylaminoimidazolecarboxamide formyltransferase","[c] : 10fthf + aicar → fprica + thf","Purine and Pyrimidine Biosynthesis","EC:2.1.2.3"]
["R_AIRC3","phosphoribosylaminoimidazole carboxylase (mutase rxn)","BLBBGE_485",null,"purE","phosphoribosylaminoimidazole mutase catalytic subunit","[c] : 5caiz → 5aizc ","Purine and Pyrimidine Biosynthesis","EC:4.1.1.21"]
["R_AKGDH","2-Oxogluterate dehydrogenase","BLBBGE_147 (also BLBBGE_214, isoenzymes), BLBBGE_597, BLBBGE_596 (also BLBBGE_009, isoenzymes), ","Enzyme complex","lpdA, sucA, sucB, respectively","dihydrolipoyl dehydrogenase, 2-oxoglutarate dehydrogenase (succinyl-transferring) E1 component, 2-oxoglutarate dehydrogenase E2 component, dihydrolipoyllysine-residue succinyltransferase, respectively","[c] : akg + coa + nad → co2 + nadh + succoa","TCA cycle ","EC:1.8.1.4; EC:1.2.4.2; EC:2.3.1.61 respectively"]
["R_ALAALAr","D-alanine-D-alanine ligase (reversible)","BLBBGE_126",null,"ddlA","D-alanine-D-alanine ligase ","[c] : (2) ala-D + atp → adp + alaala + h + pi","Cell Envelope Biosynthesis","EC:6.3.2.4"]
["R_ALATA_L","L-alanine transaminase","BLBBGE_455",null,"ilvE","branched-chain amino acid transaminase","[c] : glu-L + pyr ↔ ala-L + akg","Glutamate metabolism","EC:2.6.1.2"]
["R_AMMQLT8","S-adenosylmethione:2-demthylmenaquinole methyltransferase (menaquinone 8)","BLBBGE_110 ",null,"ubiE (menG, yigO)","ubiquinone/menaquinone biosynthesis methyltransferase","[c] : 2dmmql8 + amet → ahcys + h + mql8","Cofactor and Prosthetic Group Biosynthesis"]
["R_ANPRT","anthranilate phosphoribosyltransferase","BLBBGE_423",null,"trpD","anthranilate phosphoribosyltransferase","[c] : anth + prpp → ppi + pran","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:2.4.2.18"]
["R_ANS","anthranilate synthase","BLBBGE_421, BLBBGE_422","Enzyme complex","trpE, trpD","anthranilate synthase component I, anthranilate synthase component II","[c] : chor + gln-L → anth + glu-L + h + pyr","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.1.3.27","Mg2+, Alternative Cofactors for Mg2+: Co2+, Fe2+ "]
["R_APRAUR","5-amino-6-(5-phosphoribosylamino)uracil reductase","BLBBGE_143",null,"ribD, ribG,  ybaE","bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase ","[c] : 5apru + h + nadph → 5aprbu + nadp","Cofactor and Prosthetic Group Biosynthesis","EC:3.5.4.26; 1.1.1.193"]
["R_ARGDC","arginine decarboxylase","BLBBGE_060",null,"speA","arginine decarboxylase","[c] : arg-L + h → agm + co2","Arginine and Proline Metabolism","EC:4.1.1.19","Mg2+"]
["R_ARGN","arginase","BLBBGE_059",null,"rocF (also functions as speB)","arginase ","[c] : arg-L + h2o → orn + urea","Urea cycle/amino group metabolism","EC:3.5.3.1"]
["R_ARGSL","argininosuccinate lyase","BLBBGE_364",null,"argH","argininosuccinate lyase","[c] : argsuc → arg-L + fum","Arginine and Proline Metabolism","EC:4.3.2.1"]
["R_ARGSS","argininosuccinate synthase","BLBBGE_313",null,"argG (arg6, argE)","bifunctional argininosuccinate synthase/acetyltransferase activity of N-acetylglutamate synthase","[c] : asp-L + atp + citr-L → amp + argsuc + h + ppi","Arginine and Proline Metabolism","EC:6.3.4.5","Mg2+"]
["R_ASAD","aspartate-semialdehyde dehydrogenase","BLBBGE_299",null,"asd","aspartate-semialdehyde dehydrogenase","[c] : 4pasp + h + nadph → aspsa + nadp + pi ","Threonine and Lysine Metabolism","EC:1.2.1.11"]
["R_ASPK","aspartate kinase","BLBBGE_501",null,"thrA","bifunctional aspartokinase/homoserine dehydrogenase","[c] : asp-L + atp → 4pasp + adp","Threonine and Lysine Metabolism","EC:2.7.2.4"]
["R_ASPt2","L-aspartate transport in via proton symport","BLBBGE_358",null,"gltP","glutamate/aspartate:proton symporter","asp-L[e] + h[e] → asp-L[c] + h[c]","Transport, Extracellular"]
["R_ASPTA","aspartate transaminase","BLBBGE_355",null,"aspC","aspartate transaminase ","[c] : glu-L + oaa ↔ akg + asp-L","Alanine and Aspartate Metabolism","EC:2.6.1.1"]
["R_ATPPRT","ATP phosphoribosyltransferase","BLBBGE_433",null,"hisG","ATP phosphoribosyltransferase","[c] : atp + prpp → ppi + prbatp","Histidine Metabolism","EC:2.4.2.17"]
["R_ATPS4r","ATP synthase (four protons for one ATP)","BLBBGE_073, BLBBGE_074, BLBBGE_562, BLBBGE_563, BLBBGE_564, BLBBGE_565, BLBBGE_566, BLBBGE_567) ","Enzyme complex","atpD, atpC, atpG, atpA, atpH, atpF, atpE, atpB","ATP synthase F0 and F1 complexes: ATP synthase F1 subunit beta, ATP synthase F1 subunit epsilon, ATP synthase F1 subunit gamma, ATP synthase F1 subunit alpha, ATP synthase F1 subunit delta, ATP synthase F0 subunit B, ATP synthase F0 subunit C, ATP synthase F0 subunit A","adp[c] + (4) h[e] + pi[c] ↔ atp[c] + (3) h[c] + h2o[c]","Oxidative Phosphorylation","EC:3.6.3.14","Mg2+"]
["R_C120SN","Fatty acid biosynthesis (n-C12:0)","BLBBGE_037, BLBBGE_057, BLBBGE_079, BLBBGE_346","Enzyme complex","fabZ, fabG, fabF, fabI","bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-acyl-carrier-protein synthase II; enoyl-[acyl-carrier-protein] reductase (NADH) ","[c] : actACP + (14) h + (4) malACP + (10) nadph → (4) ACP + (4) co2 + ddcaACP + (5) h2o + (10) nadp","Membrane Lipid Metabolism","fabZ, EC:4.2.1.-,  3.5.1.-; fabG, EC:1.1.1.100; fabF, EC:2.3.1.179; fabI, EC:1.3.1.9;"]
["R_C140SN","Fatty acid biosynthesis (n-C14:0)","BLBBGE_037, BLBBGE_057, BLBBGE_079, BLBBGE_346","Enzyme complex","fabZ, fabG, fabF, fabI","bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-acyl-carrier-protein synthase II; enoyl-[acyl-carrier-protein] reductase (NADH) ","[c] : actACP + (17) h + (5) malACP + (12) nadph → (5) ACP + (5) co2 + (6) h2o + myrsACP + (12) nadp","Membrane Lipid Metabolism","fabZ, EC:4.2.1.- , 3.5.1.-; fabG, EC:1.1.1.100; fabF, EC:2.3.1.179; fabI, EC:1.3.1.9;"]
["R_C141SN","Fatty acid biosynthesis (n-C14:1)","BLBBGE_037, BLBBGE_057, BLBBGE_079 or BLBBGE_111, BLBBGE_346","Enzyme complex","fabZ, fabG, fabF or fabH, fabI","bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-acyl-carrier-protein synthase II or beta-ketoacyl-acyl-carrier-protein synthase III; enoyl-[acyl-carrier-protein] reductase (NADH) ","[c] : actACP + (16) h + (5) malACP + (11) nadph → (5) ACP + (5) co2 + (6) h2o + (11) nadp + tdeACP","Membrane Lipid Metabolism","fabZ, EC:4.2.1.-, 3.5.1.-; fabG, EC:1.1.1.100; fabF, EC: 2.3.1.179; fabH, 2.3.1.41; fabI, EC:1.3.1.9;"]
["R_C160SN","Fatty acid biosynthesis (n-C16:0)","BLBBGE_037, BLBBGE_057, BLBBGE_079, BLBBGE_346","Enzyme complex","fabZ, fabG, fabF, fabI","bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-acyl-carrier-protein synthase II; enoyl-[acyl-carrier-protein] reductase (NADH) ","[c] : actACP + (20) h + (6) malACP + (14) nadph → (6) ACP + (6) co2 + (7) h2o + (14) nadp + palmACP","Membrane Lipid Metabolism","fabZ, EC:4.2.1.-,  3.5.1.-; fabG, EC:1.1.1.100; fabF, EC:2.3.1.179; fabI, EC:1.3.1.9;"]
["R_C161SN","Fatty acid biosynthesis (n-C16:1)","BLBBGE_037, BLBBGE_057, BLBBGE_079 or BLBBGE_111, BLBBGE_346","Enzyme complex","fabZ, fabG, fabF or fabH, fabI","bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-acyl-carrier-protein synthase II or beta-ketoacyl-acyl-carrier-protein synthase III; enoyl-[acyl-carrier-protein] reductase (NADH) ","[c] : actACP + (19) h + (6) malACP + (13) nadph → (6) ACP + (6) co2 + (7) h2o + hdeACP + (13) nadp","Membrane Lipid Metabolism","fabZ, EC:4.2.1.-, 3.5.1.-; fabG, EC:1.1.1.100; fabF, EC: 2.3.1.179; fabH, 2.3.1.41; fabI, EC:1.3.1.9;"]
["R_C181SN","Fatty acid biosynthesis (n-C18:1)","BLBBGE_037, BLBBGE_057, BLBBGE_079 or BLBBGE_111, BLBBGE_346","Enzyme complex","fabZ, fabG, fabF or fabH, fabI","bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-acyl-carrier-protein synthase II or beta-ketoacyl-acyl-carrier-protein synthase III; enoyl-[acyl-carrier-protein] reductase (NADH) ","[c] : actACP + (22) h + (7) malACP + (15) nadph → (7) ACP + (7) co2 + (8) h2o + (15) nadp + octeACP","Membrane Lipid Metabolism","fabZ, EC:4.2.1.-, 3.5.1.-; fabG, EC:1.1.1.100; fabF, EC: 2.3.1.179; fabH, 2.3.1.41; fabI, EC:1.3.1.9;"]
["R_CAT","catalase","BLBBGE_349",null,"tpx","peroxiredoxin (thioredoxin peroxidase) ","[c] : (2) h2o2 →  (2) h2o + o2",null,"EC:1.11.1.15 (here acting as EC:1.11.1.6)"]
["R_CBPS","carbamoyl-phosphate synthase (glutamine-hydrolysing)","BLBBGE_316, BLBBGE_317","Enzyme complex","carA, carB","carbamoyl phosphate synthase small subunit, carbamoyl phosphate synthase large subunit ","[c] : (2) atp + gln-L + h2o + hco3 → (2) adp + cbp + glu-L + (2) h + pi","Arginine and Proline Metabolism","EC:6.3.5.5","Mg2+"]
["R_CHORM","chorismate mutase","BLBBGE_341, BLBBGE_343, BLBBGE_344","isoenzymes","pheA, tyrA, fused aroG/pheA","prephenate dehydratase; prephenate dehydrogenase;  bifunctional putative phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase","[c] : chor ↔ pphn","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:5.4.99.5"]
["R_CHORS","chorismate synthase","BLBBGE_185",null,"aroC","chorismate synthase","[c] : 3psme → chor + pi","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.2.3.5"]
["R_CS","citrate synthase","BLBBGE_540",null,"gltA","citrate synthase","[c] : accoa + h2o + oaa → cit + coa + h","TCA cycle ","EC:2.3.3.1"]
["R_CSND","Cytosine deaminase","BLBBGE_353",null,"codA","cytosine deaminase ","[c] : csn + h + h2o → nh4 + ura","Nucleotide Salvage Pathway","EC:3.5.4.1"]
["R_CTPS2","CTP synthase (glutamine)","BLBBGE_219",null,"pyrG","CTP synthetase","[c] : atp + gln-L + h2o + utp → adp + ctp + glu-L + (2) h + pi","Purine and Pyrimidine Biosynthesis","EC:6.3.4.2","Mg2+"]
["R_CYSS","cysteine synthase","BLBBGE_277",null,"cysK","cysteine synthase A","[c] : acser + h2s → ac + cys-L + h","Cysteine Metabolism","EC:2.5.1.47"]
["R_CYSTL","cystathionine b-lyase","BLBBGE_568",null,"metBC","cystathionine gamma-synthase/cystathionine beta-lyase","[c] : cyst-L + h2o → hcys-L + nh4 + pyr","Methionine Metabolism","EC 4.4.1.8"]
["R_CYTBO3","cytochrome oxidase bo3 (ubiquinol-8: 2.5 protons)","BLBBGE_414, BLBBGE_416","Enzyme complex","ccoP (for ORF BLBBGE_414)","cbb3-type cytochrome c oxidase CcoP subunit III; cbb3-type cytochrome c oxidase subunit I + II","(2.5) h[c] + (0.5) o2[c] + mql8[c] → (2.5) h[e] + h2o[c] + mqn8[c]","Oxidative Phosphorylation","EC:1.9.3.1"]
["R_CYTD","cytidine deaminase","BLBBGE_495",null,"cdd","cytidine/deoxycytidine deaminase","[c] : cytd + h + h2o → nh4 + uri","Nucleotide Salvage Pathway","EC:3.5.4.5"]
["R_CYTDK2","cytidine kinase (GTP)","BLBBGE_535",null,"udk","uridine kinase","[c] : cytd + gtp → cmp + gdp + h","Nucleotide Salvage Pathway","EC:2.7.1.48"]
["R_CYTK1","cytidylate kinase (CMP)","BLBBGE_058",null,"cmk, mssA, ycaF, ycaG","cytidylate kinase","[c] : atp + cmp ↔ adp + cdp","Nucleotide Salvage Pathway","EC:2.7.4.14","Mg2+"]
["R_CYTK2","cytidylate kinase (dCMP)","BLBBGE_058",null,"cmk, mssA, ycaF, ycaG","cytidylate kinase","[c] : atp + dcmp ↔ adp + dcdp","Nucleotide Salvage Pathway","EC:2.7.4.14","Mg2+"]
["R_DADK","deoxyadenylate kinase","BLBBGE_215",null,"adk, plsA, dnaW","adenylate kinase","[c] : atp + damp ↔ adp + dadp","Nucleotide Salvage Pathway","EC:2.7.4.3","Mg2+"]
["R_DAPDC","NAD diphosphatase","BLBBGE_331",null,"lysA","diaminopimelate decarboxylase","[c] : 26dap-M + h → co2 + lys-L","Threonine and Lysine Metabolism","EC:4.1.1.20"]
["R_DAPE","diaminopimelate epimerase","BLBBGE_397",null,"dapF","Diaminopimelate epimerase","[c] : 26dap-LL ↔ 26dap-M","Threonine and Lysine Metabolism","EC:5.1.1.7"]
["R_DASYN_Bge","CDP-Diacylglycerol synthetase","BLBBGE_224",null,"cdsA","phosphatidate cytidylyltransferase ","[c] : ctp + h + (0.02) pa_Bge → (0.02) cdpdag_Bge + ppi","Membrane Lipid Metabolism","EC:2.7.7.41","Mg2+"]
["R_DB4PS","3,4-Dihydroxy-2-butanone-4-phosphate synthase","BLBBGE_323",null,"ribBA","Bifunctional 3,4 dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II. Only the first activity","[c] : ru5p-D → db4p + for + h","Cofactor and Prosthetic Group Biosynthesis","EC:4.1.99.12","Mg2+"]
["R_DCMPDA","dCMP deaminase","BLBBGE_505",null,"comEB","dCMP deaminase","[c] : dcmp + h + h2o ↔ dump + nh4","Nucleotide Salvage Pathway","EC:3.5.4.12"]
["R_DCYTD","deoxycytidine deaminase","BLBBGE_495",null,"cdd","cytidine/deoxycytidine deaminase","[c] : dcyt + h + h2o → duri + nh4","Nucleotide Salvage Pathway","EC:3.5.4.14"]
["R_DDPA","3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase","BLBBGE_344",null,"fused aroG/pheA","bifunctional putative phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase (EC:2.5.1.54 4.2.1.51 5.4.99.5)","[c] : e4p + h2o + pep → 2dda7p + pi","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:2.5.1.54"]
["R_DGK1","deoxyguanylate kinase (dGMP:ATP)","BLBBGE_298",null,"gmk","guanylate kinase","[c] : atp + dgmp ↔ adp + dgdp","Nucleotide Salvage Pathway","EC:2.7.4.8"]
["R_DHAD1","dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)","BLBBGE_557",null,"ilvD","dihydroxy-acid dehydratase","[c] : 23dhmb → 3mob + h2o","Valine, Leucine, and Isoleucine Metabolism","EC:4.2.1.9"]
["R_DHAD2","Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)","BLBBGE_557",null,"ilvD","dihydroxy-acid dehydratase","[c] : 23dhmp → 3mop + h2o","Valine, Leucine, and Isoleucine Metabolism","EC:4.2.1.9"]
["R_DHDPRy","dihydrodipicolinate reductase (NADPH)","BLBBGE_551",null,"dapB","dihydrodipicolinate reductase ","[c] : 23dhdp + h + nadph-> nadp + thdp","Threonine and Lysine Metabolism","EC:1.3.1.26"]
["R_DHDPS","dihydrodipicolinate synthase","BLBBGE_210",null,"dapA","dihydrodipicolinate synthase","[c] : aspsa + pyr → 23dhdp + h + (2) h2o","Threonine and Lysine Metabolism","EC:4.2.1.52"]
["R_DHFR","dihydrofolate reductase","BLBBGE_449",null,"folA","dihydrofolate reductase","[c] : dhf + h + nadph ↔ nadp + thf","Cofactor and Prosthetic Group Biosynthesis","EC:1.5.1.3"]
["R_DHFS","dihydrofolate synthase","BLBBGE_182",null,"folC","bifunctional folylpolyglutamate synthase/dihydrofolate synthase","[c] : atp + dhpt + glu-L → adp + dhf + pi","Cofactor and Prosthetic Group Biosynthesis","EC:6.3.2.12,-!-,6.3.2.17"]
["R_DHNAOT","1,4-dihydroxy-2-naphthoate octaprenyltransferase","BLBBGE_268",null,"menA","1,4-dihydroxy-2-naphthoate octaprenyltransferase ","[c] : dhna + octdp → 2dmmq8 + co2 + h + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.-"]
["R_DHNPA2","dihydroneopterin aldolase","BLBBGE_292",null,"folB","dihydroneopterin aldolase","[c] : dhnpt ↔ 6hmhpt + gcald","Cofactor and Prosthetic Group Biosynthesis","EC:4.1.2.25"]
["R_DHORD5","dihydroorotic acid (menaquinone-8)","BLBBGE_513",null,"pyrD","dihydroorotate dehydrogenase ","[c] : dhor-S + mqn8 → mql8 + orot","Purine and Pyrimidine Biosynthesis","EC:1.3.5.2"]
["R_DHPPDA2","diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)","BLBBGE_143",null,"ribD, ribG,  ybaE","bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase ","[c] : 25drapp + h + h2o → 5apru + nh4","Cofactor and Prosthetic Group Biosynthesis","EC:3.5.4.26; 1.1.1.193"]
["R_DHPS2","dihydropteroate synthase","BLBBGE_102 ",null,"folP","Dihydropteroate synthase","[c] : 4abz + 6hmhptpp → dhpt + h + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.15","Mg2+"]
["R_DHQD","3-dehydroquinate dehydratase","BLBBGE_083",null,"aroD","3-dehydroquinate dehydratase","[c] : 3dhq ↔ 3dhsk + h2o","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.2.1.10"]
["R_DHQS","3-dehydroquinate synthase","BLBBGE_493",null,"aroB","3-dehydroquinate synthase","[c] : 2dda7p → 3dhq + pi","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.2.3.4","Co2+"]
["R_DNTPPA","Dihydroneopterin triphosphate pyrophosphatase","BLBBGE_190",null,"idi","isopentenyl-diphosphate delta-isomerase ","[c] : ahdt + h2o → dhpmp + h + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:3.6.1.-","Mg2+, Mn2+"]
["R_DPCOAK","dephospho-CoA kinase","BLBBGE_196",null,"coaE","dephospho-CoA kinase","[c] : atp + dpcoa → adp + coa + h","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.1.24"]
["R_DPMVDx","diphosphomevalonate decarboxylase","BLBBGE_357",null,"mvaD","diphosphomevalonate decarboxylase","[c] : 5dpmev + atp → adp + co2 + ipdp + pi","Cell Envelope Biosynthesis","EC:4.1.1.33"]
["R_DURIPP","deoxyuridine phosphorylase","BLBBGE_377",null,"pndA (but probably acting as deoD)","purine nucleoside phosphorylase","[c] : duri + pi ↔ 2dr1p + ura","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_DUTPDP","dUTP diphosphatase","BLBBGE_606, BLBBGE_p003","isoenzymes","dut","dUTP diphosphatase","[c] : dutp + h2o → dump + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.23","Zn2+"]
["R_E4PD","Erythrose 4-phosphate dehydrogenase","BLBBGE_043",null,"gapA (performing in this reaction the function associated to epd gene)","glyceraldehyde-3-phosphate dehydrogenase A (acting here as D-erythrose 4-phosphate dehydrogenase)","[c] : e4p + h2o + nad ↔ 4per + (2) h + nadh","Cofactor and Prosthetic Group Biosynthesis","EC:1.2.1.9"]
["R_ENO","enolase","BLBBGE_264",null,"eno","enolase","[c] : 2pg ↔ h2o + pep","Glycolysis/Gluconeogenesis","EC:4.2.1.11","Mg2+"]
["R_FBAa","fructose-bisphosphate aldolaseA","BLBBGE_476",null,"fba","fructose-bisphosphate aldolase, class II ","[c] :  dhap + g3p ↔ fdp","Glycolysis/Gluconeogenesis","EC:4.1.2.13"]
["R_FBAb","fructose-bisphosphate aldolaseB","BLBBGE_476",null,"fba","fructose-bisphosphate aldolase, class II ","[c] :  dhap + glyald ↔ f1p ","Glycolysis/Gluconeogenesis","EC:4.1.2.13"]
["R_FBP","fructose-bisphosphatase","BLBBGE_509",null,"fbp","fructose-bisphosphatase","[c] : fdp + h2o → f6p + pi","Glycolysis/Gluconeogenesis","EC:3.1.3.11","Mg2+"]
["R_FE2abc","iron (II) transport via ABC system","BLBBGE_127",null,"feoB","ferrous iron transport protein B","atp[c] + fe2[e] + h2o[c] → adp[c] + fe2[c] + h[c] + pi[c]","Transport, Extracellular"]
["R_FMNAT","FMN adenylyltransferase","BLBBGE_072",null,"ribF, yaaC","bifunctional riboflavin kinase/FAD synthetase ","[c] : atp + fmn + h → fad + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.1.26; 2.7.7.2"]
["R_FOMETR","aminomethyltransferase","BLBBGE_188",null,"gcvT","aminomethyltransferase","[c] : 5fthf + h ↔ h2o + methf","Cofactor and Prosthetic Group Biosynthesis","EC:2.1.2.10"]
["R_FRUt1r","D-fructose transport in via uniport","BLBBGE_199",null,null,"ABC transporter, ATP-binding and permease protein","fru[e] ↔ fru[c]","Transport, Extracellular"]
["R_FTHFCL","5-formethyltetrahydrofolate cyclo-ligase","BLBBGE_130",null,"ygfA","5-formyltetrahydrofolate cyclo-ligase","[c] : 5fthf + atp → adp + methf + pi","Cofactor and Prosthetic Group Biosynthesis","EC:6.3.3.2"]
["R_FUM","fumarase","BLBBGE_536",null,"fumC","fumarate hydratase, class II","[c] : fum + h2o ↔ mal-L","TCA cycle ","EC:4.2.1.2"]
["R_FUMt2_2","Fumarate transport via proton symport (2 H)","BLBBGE_358",null,"gltP (but functions here as dctA)","glutamate/aspartate:proton symporter","fum[e] + (2) h[e] → fum[c] + (2) h[c]","Transport, Extracellular"]
["R_G1PACT","glucosamine-1-phosphate N-acetyltransferase","BLBBGE_605",null,"galU","UTP-glucose-1-phosphate uridylyltransferase","[c] : accoa + gam1p -> acgam1p + coa + h","Cell Envelope Biosynthesis","EC:2.3.1.157"]
["R_G3PD5","glycerol-3-phosphate dehydrogenase (ubiquinone-8)","BLBBGE_458",null,"glpD","glycerol-3-phosphate dehydrogenase","[c] : glyc3p + mqn8 ↔ dhap + mql8","Oxidative Phosphorylation","EC:1.1.5.3"]
["R_GAPD","glyceraldehyde-3-phosphate dehydrogenase","BLBBGE_043",null,"gapA","glyceraldehyde-3-phosphate dehydrogenase A","[c] : 13dpg + h + nadh ↔ g3p + nad + pi","Glycolysis/Gluconeogenesis","EC:1.2.1.12"]
["R_GARFT","phosphoribosylglycinamide formyltransferase","BLBBGE_481",null,"purN","phosphoribosylglycinamide formyltransferase","[c] : 10fthf + gar → fgam + h + thf","Purine and Pyrimidine Biosynthesis","EC:2.1.2.2"]
["R_GF6PTA","glutamine-fructose-6-phosphate transaminase","BLBBGE_289",null,"glmS","glutamine-fructose-6-phosphate transaminase (isomerizing)","[c] : f6p + gln-L → gam6p + glu-L","Cell Envelope Biosynthesis","EC:2.6.1.16"]
["R_GK1","guanylate kinase (GMP:ATP)","BLBBGE_298",null,"gmk","guanylate kinase","[c] : atp + gmp ↔ adp + gdp","Nucleotide Salvage Pathway","EC:2.7.4.8","Mg2+"]
["R_GLUDy","glutamate dehydrogenase (NADP)","BLBBGE_121",null,"gdhA","glutamate dehydrogenase (NADP+)","[c] : glu-L + h2o + nadp ↔ akg + h + nadph + nh4","Glutamate metabolism","EC:1.4.1.4"]
["R_GLUPRT","glutamine phosphoribosyldiphosphate amidotransferase","BLBBGE_483",null,"purF","amidophosphoribosyltransferase","[c] : gln-L + h2o + prpp → glu-L + ppi + pram","Purine and Pyrimidine Biosynthesis","EC:2.4.2.14","Mg2+"]
["R_GLUR","glutamate racemase","BLBBGE_411",null,"murI","glutamate racemase","[c] : glu-L ↔ glu-D","Cell Envelope Biosynthesis","EC:5.1.1.3"]
["R_GLUt2r","L-glutamate transport via proton symport","BLBBGE_358",null,"gltP","glutamate/aspartate:proton symporter","glu-L[e] + h[e] → glu-L[c] + h[c]","Transport, Extracellular"]
["R_GLYALDt","Glyceraldehyde facilitated diffusion","BLBBGE_460",null,"glpF","putative glycerol diffusion channel","glyald[e] ↔ glyald[c]","Transport, Extracellular"]
["R_GLYCL","Glycine Cleavage System","BLBBGE_147, BLBBGE_616, BLBBGE_418, BLBBGE_188 ","Enzyme complex","lpdA, gcvP, gcvH, gcvT","dihydrolipoyl dehydrogenase, glycine decarboxylase (PLP-dependent, subunit (protein P) of glycine cleavage complex; glycine cleavage complex lipoylprotein, H protein; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex","[c] : gly + nad + thf ↔ co2 + mlthf + nadh + nh4 ","Folate Metabolism","lpdA, EC:1.8.1.4; gcvP, EC:1.4.4.2; gcvT, EC:2.1.2.10"]
["R_GLYCt","glycerol transport via channel","BLBBGE_460",null,"glpF","putative glycerol diffusion channel","glyc[e] ↔ glyc[c]","Transport, Extracellular"]
["R_GLYK","glycerol kinase","BLBBGE_459",null,"glpK","glycerol kinase","[c] : atp + glyc → adp + glyc3p + h","Alternate Carbon Metabolism","EC:2.7.1.30","Mg2+, Alternative Cofactors for Mg2+: Mn2+ "]
["R_GLYt","Glycine transport via diffusion","BLBBGE_460",null,"glpF","putative glycerol diffusion channel","gly[e] ↔ gly[c]","Transport, Extracellular"]
["R_GMPS2","GMP synthase","BLBBGE_478",null,"guaA","bifunctional GMP synthase/glutamine amidotransferase protein","[c] : atp + gln-L + h2o + xmp → amp + glu-L + gmp + (2) h + ppi","Purine and Pyrimidine Biosynthesis","EC:6.3.5.2","Mg2+"]
["R_GTPCI","GTP cyclohydrolase I","BLBBGE_570",null,"folE","GTP cyclohydrolase I","[c] : gtp + h2o → ahdt + for","Cofactor and Prosthetic Group Biosynthesis","EC:3.5.4.16","Zn2+"]
["R_GTPCII2","GTP cyclohydrolase II (25drapp)","BLBBGE_323",null,"ribBA","Bifunctional 3,4 dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II. Only the first activity","[c] : gtp + (3) h2o → 25drapp + for + (2) h + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:3.5.4.25"]
["R_HISTD","histidinol dehydrogenase","BLBBGE_434",null,"hisD","histidinol dehydrogenase","[c] : h2o + histd + (2) nad → (3) h + his-L + (2) nadh","Histidine Metabolism","EC:1.1.1.23","Mn2+"]
["R_HISTP","histidinol-phosphatase","BLBBGE_436",null,"hisB","bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase ","[c] : h2o + hisp → histd + pi","Histidine Metabolism","EC:3.1.3.15","Mg2+"]
["R_HMBS","hydroxymethylbilane synthase","BLBBGE_573",null,"hemC","hydroxymethylbilane synthase (porphobilinogen deaminase)","[c] : h2o + (4) ppbng → hmbil + (4) nh4","Cofactor and Prosthetic Group Biosynthesis","EC:4.3.1.8 (synonyms: EC 2.5.1.61)"]
["R_HPPK2","6-hydroxymethyl-dihydropterin pyrophosphokinase","BLBBGE_627",null,"folK","2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase ","[c] : 6hmhpt + atp → 6hmhptpp + amp + h","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.6.3","Mg2+"]
["R_HSDy","homoserine dehydrogenase (NADPH)","BLBBGE_501",null,"thrA","bifunctional aspartokinase/homoserine dehydrogenase","[c] : aspsa + h + nadph → hom-L + nadp","Threonine and Lysine Metabolism","EC:1.1.1.3"]
["R_HSK","homoserine kinase","BLBBGE_500",null,"thrB","homoserine kinase","[c] : atp + hom-L → adp + h + phom","Threonine and Lysine Metabolism","EC:2.7.1.39"]
["R_HSTPT","histidinol-phosphate transaminase","BLBBGE_435",null,"hisC","histidinol-phosphate transaminase","[c] : glu-L + imacp ↔ akg + hisp","Histidine Metabolism","EC:2.6.1.9"]
["R_ICDHyr","isocitrate dehydrogenase (NADP)","BLBBGE_272",null,"icd","isocitrate dehydrogenase (NADP+)","[c] : icit + nadp → akg + co2 + nadph","TCA cycle ","EC:1.1.1.42","Mn2+ (Alternative Cofactors for Mn2+: Mg2+)"]
["R_ICHORSi","Isochorismate Synthase","BLBBGE_192",null,"entC","isochorismate synthase ","[c] : chor → ichor","Cofactor and Prosthetic Group Biosynthesis","EC:5.4.4.2","Mg2+"]
["R_IG3PS","Imidazole-glycerol-3-phosphate synthase","BLBBGE_437, BLBBGE_439","Enzyme complex","hisH, hisF","imidazole glycerol phosphate synthase subunit HisH, imidazole glycerol phosphate synthase, cyclase subunit","[c] : gln-L + prlp → aicar + eig3p + glu-L + h","Histidine Metabolism","EC:2.4.2.-",{"$nulls":5},"(OR, isoenzimas) por cysM, para el cual no existe ortólogo en Blattella; por BLAST de b2421 (cysM) me dirige de nuevo a esta región. En MetaCyc esta reacción es reversible; en BRENDA hay datos de los dos tipos, aunque predominan los reversibles, mientras que en KEGG es irreversible. Lo voy a modificar, puesto que en BRENDA existen muchas evidencias de reversibilidad."]
["R_IGPDH","imidazoleglycerol-phosphate dehydratase","BLBBGE_436",null,"hisB","bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase ","[c] : eig3p → h2o + imacp","Histidine Metabolism","EC:4.2.1.19 ","Mg2+"]
["R_IGPS","indole-3-glycerol-phosphate synthase","BLBBGE_424",null,"trpC","indole-3-glycerol-phosphate synthase","[c] : 2cpr5p + h → 3ig3p + co2 + h2o","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.1.1.48"]
["R_ILETA","isoleucine transaminase","BLBBGE_455",null,"ilvE","branched-chain amino acid transaminase","[c] : 3mop + glu-L ↔ akg + ile-L ","Valine, Leucine, and Isoleucine Metabolism","EC:2.6.1.42"]
["R_IMPC","IMP cyclohydrolase","BLBBGE_480",null,"purH","phosphoribosylaminoimidazolecarboxamide formyltransferase","[c] : fprica → h2o + imp","Purine and Pyrimidine Biosynthesis","EC:3.5.4.10"]
["R_IMPD","IMP dehydrogenase","BLBBGE_160",null,"guaB","inosine-5'-monophosphate dehydrogenase","[c] : h2o + imp + nad → h + nadh + xmp","Purine and Pyrimidine Biosynthesis","EC:1.1.1.205"]
["R_IPDDIi","isopentenyl-diphosphate D-isomerase","BLBBGE_190",null,"idi","isopentenyl-diphosphate delta-isomerase ","[c] : ipdp ↔ dmpp","Cofactor and Prosthetic Group Biosynthesis","EC:5.3.3.2","Mg2+, Zn2+ (alternative Cofactors for Mg2+: Mn2+)"]
["R_IPMD","3-isopropylmalate dehydrogenase","BLBBGE_070",null,"leuB (misannotated as leuD)","3-isopropylmalate dehydrogenase ","[c] : 3c2hmp + nad → 3c4mop + h + nadh","Valine, Leucine, and Isoleucine Metabolism","EC:1.1.1.85","Cofactors: Mg2+, Mn2+ ","en MetaCyc es reversible"]
["R_IPPMIa","3-isopropylmalate dehydratase","BLBBGE_068, BLBBGE_069","Enzyme complex","leuC (misannotated as leuB), leuD (misannotated as leuC)","3-isopropylmalate isomerase subunit dehydratase component, 3-isopropylmalate isomerase subunit  ","[c] : 2ippm + h2o ↔ 3c2hmp","Valine, Leucine, and Isoleucine Metabolism","EC:4.2.1.33"]
["R_IPPMIb","2-isopropylmalate hydratase","BLBBGE_068, BLBBGE_069","Enzyme complex","leuC (misannotated as leuB), leuD (misannotated as leuC)","3-isopropylmalate isomerase subunit dehydratase component, 3-isopropylmalate isomerase subunit ","[c] : 3c3hmp ↔ 2ippm + h2o","Valine, Leucine, and Isoleucine Metabolism","EC:4.2.1.33"]
["R_IPPS","2-isopropylmalate synthase","BLBBGE_067",null,"leuA","2-isopropylmalate synthase ","[c] : 3mob + accoa + h2o → 3c3hmp + coa + h","Valine, leucine, and isoleucine metabolism","EC:2.3.3.13"]
["R_KARA1i","acetohydroxy acid isomeroreductase","BLBBGE_554",null,"ilvC","ketol-acid reductoisomerase","[c] : alac-S + h + nadph → 23dhmb + nadp","Valine, Leucine, and Isoleucine Metabolism","EC:1.1.1.86"]
["R_KARA2i","ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate)","BLBBGE_554",null,"ilvC","ketol-acid reductoisomerase","[c] : 2ahbut + h + nadph → 23dhmp + nadp","Valine, Leucine, and Isoleucine Metabolism","EC:1.1.1.86"]
["R_KAS14","beta-ketoacyl-ACP synthase","BLBBGE_079",null,"fabF","Beta-ketoacyl-acyl-carrier-protein synthase II","[c] : acACP + h + malACP → ACP + actACP + co2","Membrane Lipid Metabolism","EC:2.3.1.179"]
["R_KAS15","beta-ketoacyl-ACP synthase (2)","BLBBGE_111",null,"fabH","beta-ketoacyl-acyl-carrier-protein synthase III","[c] : accoa + h + malACP → actACP + co2 + coa","Membrane Lipid Metabolism","EC:2.3.1.41"]
["R_KAS16","3-hydroxy-myristoyl-ACP synthesis","BLBBGE_057, BLBBGE_079","Enzyme complex","fabG, fabF","3-oxoacyl-[acyl-carrier-protein] reductase, Beta-ketoacyl-acyl-carrier-protein synthase II","[c] : ddcaACP + (2) h + malACP + nadph → 3hmrsACP + ACP + co2 + nadp","Membrane Lipid Metabolism","fabF, EC:2.3.1.179; fabG, EC:1.1.1.100"]
["R_KHK","ketohexokinase","BLBBGE_008",null,null,"carbohydrate kinase","[c] : atp + fru → adp + f1p + h","Fructose and Mannose Metabolism","EC: 2.7.1.3"]
["R_Kt2r","potassium reversible transport via proton symport","BLBBGE_574, BLBBGE_575","Enzyme complex","ktrB, ktrA","K+ uptake transporter subunit KtrB, K+ uptake transporter subunit KtrA","h[e] + k[e] ↔ h[c] + k[c]","Transport, Extracellular"]
["R_LEUTA","leucine transaminase","BLBBGE_342, BLBBGE_455","isoenzymes","tyrB, ilvE","transaminase, branched-chain amino acid transaminase","[c] : 4mop + glu-L ↔ akg + leu-L","Valine, Leucine, and Isoleucine Metabolism","EC:2.6.1.42"]
["R_MALt2_2","Malate transport via proton symport (2 H)","BLBBGE_358",null,"gltP (but functions here as dctA)","glutamate/aspartate:proton symporter","(2) h[e] + mal-L[e] → (2) h[c] + mal-L[c]","Transport, Extracellular"]
["R_MCOATA","Malonyl-CoA-ACP transacylase","BLBBGE_538",null,"fabD","malonyl CoA-acyl carrier protein transacylase ","[c] : ACP + malcoa → coa + malACP","Membrane Lipid Metabolism","EC:2.3.1.39"]
["R_MDH","malate dehydrogenase","BLBBGE_617",null,"mdh","malate dehydrogenase","[c] : mal-L + nad ↔ h + nadh + oaa","TCA cycle ","EC:1.1.1.37"]
["R_ME2","malic enzyme (NADP)","BLBBGE_412",null,"maeB","bifunctional malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)/phosphate acetyltransferase","[c] : mal-L + nadp → co2 + nadph + pyr","Anaplerotic reactions","EC:1.1.1.40; 2.3.1.8","Mn2+, Alternative Cofactors for Mn2+: Mg2+"]
["R_METAT","methionine adenosyltransferase","BLBBGE_345",null,"metK","methionine adenosyltransferase","[c] : atp + h2o + met-L → amet + pi + ppi","Methionine Metabolism","EC:2.5.1.6"]
["R_METS","methionine synthase","BLBBGE_114",null,"metE","5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (cobalamin-independent homocysteine transmethylase)","[c] : 5mthf + hcys-L↔ met-L + thf","Methionine Metabolism","EC:2.1.1.14","Zn2+"]
["R_MEVK1x","mevalonate kinase","BLBBGE_085",null,"mvaK/mvaK2","mevalonate kinase","[c] : atp + mev-R → 5pmev + adp + h","Cell Envelope Biosynthesis","EC:2.7.1.36"]
["R_MTHFC","methenyltetrahydrofolate cyclohydrolase","BLBBGE_442",null,"folD","bifunctional methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase ","[c] : h2o + methf ↔ 10fthf","Folate Metabolism","EC:3.5.4.9"]
["R_MTHFD","methylenetetrahydrofolate dehydrogenase (NADP)","BLBBGE_442",null,"folD","bifunctional methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase ","[c] : mlthf + nadp ↔ h + methf + nadph","Folate Metabolism","EC:1.5.1.5"]
["R_MTHFR2","5,10-methylenetetrahydrofolate reductase (NADH)","BLBBGE_445",null,"metF","5,10-methylenetetrahydrofolate reductase","[c] : h + mlthf + nadh ↔ 5mthf + nad","Folate Metabolism","EC:1.5.1.20","FAD"]
["R_NACODA","N-acetylornithine deacetylase","BLBBGE_320",null,"argE","bifunctional peptidase/acetylornithine deacetylase","[c] : acg5sa + h2o → ac + glu5sa","Arginine and Proline Metabolism","EC:3.5.1.16","Zn2+"]
["R_NADDP","NAD diphosphatase","BLBBGE_333",null,"ligA","DNA ligase","[c] : h2o + nad → amp + (2) h + nmn","Cofactor and Prosthetic Group Biosynthesis","EC:6.5.1.2","Mg2+"]
["R_NADH10","NADH dehydrogenase (menaquinone-8 &amp; 0 protons)","BLBBGE_193",null,"ndh","NADH dehydrogenase (menaquinone)","[c] : h + mqn8 + nadh → mql8 + nad","Oxidative Phosphorylation","EC:1.6.5.3","Mg2+"]
["R_NADH7","NADH dehydrogenase (menaquinone-8 &amp; 2 protons)","BLBBGE_193",null,"ndh","NADH dehydrogenase (menaquinone)","(3) h[c] + mqn8[c] + nadh[c] → (2) h[e] + mql8[c] + nad[c]","Oxidative Phosphorylation","EC:1.6.5.3","Mg2+"]
["R_NADH8","NADH dehydrogenase (demethylmenaquinone-8 &amp; 2.8 protons)","BLBBGE_193",null,"ndh","NADH dehydrogenase (menaquinone)","2dmmq8[c] + (3.8) h[c] + nadh[c] → 2dmmql8[c] + (2.8) h[e] + nad[c]","Oxidative Phosphorylation","EC:1.6.5.3","Mg2+"]
["R_NADH9","NADH dehydrogenase (demethylmenaquinone-8 &amp; 0 protons)","BLBBGE_193",null,"ndh","NADH dehydrogenase (menaquinone)","[c] : 2dmmq8 + h + nadh → 2dmmql8 + nad","Oxidative Phosphorylation","EC:1.6.5.3","Mg2+"]
["R_NADK","NAD kinase","BLBBGE_086",null,"ppnK","NAD+ kinase","[c] : atp + nad → adp + h + nadp","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.1.23","Mg2+"]
["R_NADS1","NAD synthase (nh3)","BLBBGE_571",null,"nadE","NAD+ synthase","[c] : atp + dnad + nh4 → amp + h + nad + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:6.3.5.1","Mg2+, Alternative Cofactors for Mg2+: Mn2+ "]
["R_NAMNPP","nicotinic acid mononucleotide pyrophosphorylase","BLBBGE_208",null,"pncB","nicotinate phosphoribosyltransferase ","[c] : atp + h2o + nac + prpp → adp + nicrnt + pi + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.4.2.11"]
["R_NDPK1","nucleoside-diphosphate kinase (ATP:GDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + gdp ↔ adp + gtp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK2","nucleoside-diphosphate kinase (ATP:UDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + udp ↔ adp + utp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK3","nucleoside-diphosphate kinase (ATP:CDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + cdp ↔ adp + ctp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK4","nucleoside-diphosphate kinase (ATP:dTDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + dtdp ↔ adp + dttp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK5","nucleoside-diphosphate kinase (ATP:dGDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + dgdp ↔ adp + dgtp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK6","nucleoside-diphosphate kinase (ATP:dUDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + dudp ↔ adp + dutp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK7","nucleoside-diphosphate kinase (ATP:dCDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + dcdp ↔ adp + dctp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK8","nucleoside-diphosphate kinase (ATP:dADP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + dadp ↔ adp + datp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NDPK9","nucleoside-diphosphate kinase (ATP:IDP)","BLBBGE_453",null,"ndk","nucleoside-diphosphate kinase","[c] : atp + idp ↔ adp + itp","Nucleotide Salvage Pathway","EC:2.7.4.6","Mg2+"]
["R_NMNAT","nicotinamide-nucleotide adenylyltransferase","BLBBGE_327",null,"nadD","nicotinate-nucleotide adenylyltransferase ","[c] : atp + h + nmn → nad + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.7.18","Mg2+"]
["R_NNAT","nicotinate-nucleotide adenylyltransferase","BLBBGE_327",null,"nadD","nicotinate-nucleotide adenylyltransferase ","[c] : atp + h + nicrnt → dnad + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.7.18","Mg2+"]
["R_NPHS","naphthoate synthase","BLBBGE_267",null,"menB","naphthoate synthase ","[c] : sbzcoa → coa + dhna","Cofactor and Prosthetic Group Biosynthesis","EC:4.1.3.36"]
["R_NTPP1","Nucleoside triphosphate pyrophosphorylase (dgtp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : dgtp + h2o → dgmp + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPP2","Nucleoside triphosphate pyrophosphorylase (gtp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : gtp + h2o → gmp + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPP3","Nucleoside triphosphate pyrophosphorylase (dctp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : dctp + h2o → dcmp + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPP4","Nucleoside triphosphate pyrophosphorylase (ctp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : ctp + h2o → cmp + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPP5","Nucleoside triphosphate pyrophosphorylase (datp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : datp + h2o → damp + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPP6","Nucleoside triphosphate pyrophosphorylase (atp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : atp + h2o → amp + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPP7","Nucleoside triphosphate pyrophosphorylase (dttp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : dttp + h2o → dtmp + h + ppi","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPP8","Nucleoside triphosphate pyrophosphorylase (utp)","BLBBGE_405",null,"mazG","nucleoside-triphosphate diphosphatase","[c] : h2o + utp → h + ppi + ump","Nucleotide Salvage Pathway","EC:3.6.1.19","Mg2+"]
["R_NTPTP1","Nucleoside triphosphate tripolyhydrolase","BLBBGE_612",null,"dgt","putative transmembrane HD family protein","[c] : dgtp + h2o → dgsn + ppi","Nucleotide Salvage Pathway","EC:3.1.5.1","Mg2+"]
["R_NTPTP2","Nucleoside triphosphate tripolyhydrolase","BLBBGE_612",null,"dgt","putative transmembrane HD family protein","[c] : gtp + h2o → gsn + ppi","Nucleotide Salvage Pathway","EC:3.1.5.1","Mg2+"]
["R_OCBT","ornithine carbamoyltransferase","BLBBGE_318",null,"argF","ornithine carbamoyltransferase ","[c] : cbp + orn → citr-L + h + pi","Arginine and Proline Metabolism","EC:2.1.3.3"]
["R_OCTDPS","Octaprenyl pyrophosphate synthase","BLBBGE_303",null,"ispB","polyprenyl synthetase family protein ","[c] : frdp + (5) ipdp → octdp + (5) ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.-"]
["R_OHPBAT","O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase","BLBBGE_144, BLBBGE_428","isoenzymes","serC","phosphoserine transaminase","[c] : glu-L + ohpb ↔  akg + phthr","Cofactor and Prosthetic Group Biosynthesis","EC:2.6.1.52"]
["R_OMBZLM","2-Octaprenyl-6-methoxy-benzoquinol methylase","BLBBGE_110 ",null,"ubiE (menG, yigO)","ubiquinone/menaquinone biosynthesis methyltransferase","[c] : 2ombzl + amet → 2ommbl + ahcys + h","Cofactor and Prosthetic Group Biosynthesis","EC:2.1.1.-"]
["R_OMCDC","2-Oxo-4-methyl-3-carboxypentanoate decarboxylation","BLBBGE_070",null,"leuB (misannotated as leuD)","3-isopropylmalate dehydrogenase ","[c] : 3c4mop + h → 4mop + co2","Valine, Leucine, and Isoleucine Metabolism","EC:1.1.1.85","Cofactors: Mg2+, Mn2+ "]
["R_OMPDC","orotidine-5&apos;-phosphate decarboxylase","BLBBGE_512",null,"pyrFE (misannotated only as pyrF)","orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase","[c] : h + orot5p → co2 + ump","Purine and Pyrimidine Biosynthesis","EC:4.1.1.23"]
["R_ORPT","orotate phosphoribosyltransferase","BLBBGE_512",null,"pyrFE (misannotated only as pyrF)","orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase","[c] : orot + prpp → orot5p + ppi","Purine and Pyrimidine Biosynthesis","EC:2.4.2.10"]
["R_OXGDC2","2-oxoglutarate decarboxylase","BLBBGE_056",null,"menD","bifunctional 2-oxoglutarate decarboxylase/2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase","[c] : akg + h + thmpp → co2 + ssaltpp","Cofactor and Prosthetic Group Biosynthesis","EC:4.1.1.71","Mg2+"]
["R_PAPPT3","phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)","BLBBGE_389",null,"mraY","phospho-N-acetylmuramoyl-pentapeptide-transferase ","[c] : udcpp + ugmda → uagmda + ump","Cell Envelope Biosynthesis","EC:2.7.8.13"]
["R_PAPSR","phosphoadenylyl-sulfate reductase (thioredoxin)","BLBBGE_273",null,"cysH","phosphoadenylyl-sulfate reductase (thioredoxin) ","[c] : paps + trdrd → (2) h + pap + so3 + trdox","Cysteine Metabolism","EC:1.8.4.8"]
["R_PASYN_Bge","Phosphatidic acid synthase","BLBBGE_508, BLBBGE_599","Enzyme complex","plsC, plsB","1-acylglycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O-acyltransferase","[c] : glyc3p + (0.14) hdeACP + (0.04) myrsACP + octeACP + (0.72) palmACP + (0.1) tdeACP → (2) ACP + (0.02) pa_Bge","Membrane Lipid Metabolism","EC:2.3.1.51; EC:2.3.1.15"]
["R_PDH","pyruvate dehydrogenase","BLBBGE_147, BLBBGE_098, BLBBGE_099, BLBBGE_446","Enzyme complex","lpdA, aceF, pdhA, pdhB","dihydrolipoyl dehydrogenase, glycine decarboxylase (PLP-dependent, subunit (protein P) of glycine cleavage complex; pyruvate dehydrogenase E2 component, dihydrolipoyltransacetylase component E2; pyruvate dehydrogenase E1 component subunit alpha; pyruvate dehydrogenase E1 component subunit beta","[c] : coa + nad + pyr → accoa + co2 + nadh","Glycolysis/Gluconeogenesis","EC 1.8.1.4; EC:2.3.1.12; EC:1.2.4.1, respectively","TPP"]
["R_PDX5PO","pyridoxine 5&apos;-phosphate oxidase","BLBBGE_050",null,"pdxH","pyridoxamine 5'-phosphate oxidase","[c] : o2 + pdx5p → h2o2 + pydx5p","Cofactor and Prosthetic Group Biosynthesis","EC:1.4.3.5"]
["R_PDX5PS","Pyridoxine 5&apos;-phosphate synthase","BLBBGE_015, BLBBGE_075","Enzyme complex","pdxJ, pdxA","pyridoxine 5'-phosphate synthase, 4-hydroxythreonine-4-phosphate dehydrogenase, respectively","[c] : dxyl5p + nad + phthr → co2 + h + (2) h2o + nadh + pdx5p + pi","Cofactor and Prosthetic Group Biosynthesis","EC:2.6.99.2, EC:1.1.1.262 respectively","Zn2+"]
["R_PGAMT","phosphoglucosamine mutase","BLBBGE_157",null,"¿manB, cpsG?","phosphoglucomutase/phosphomannomutase family protein ","[c] : gam6p ↔ gam1p","Cell Envelope Biosynthesis","EC:5.4.2.10"]
["R_PGCD","phosphoglycerate dehydrogenase","BLBBGE_283",null,"serA","phosphoglycerate dehydrogenase","[c] : 3pg + nad ↔ 3php + h + nadh","Glycine and Serine Metabolism","EC:1.1.1.95"]
["R_PGK","phosphoglycerate kinase","BLBBGE_294",null,"pgk","phosphoglycerate kinase","[c] : 3pg + atp ↔ 13dpg + adp","Glycolysis/Gluconeogenesis","EC:2.7.2.3"]
["R_PGM","phosphoglycerate mutase","BLBBGE_231",null,"gpmA","phosphoglycerate mutase ","[c] : 2pg ↔ 3pg","Glycolysis/Gluconeogenesis","EC:5.4.2.1"]
["R_PHETA1","phenylalanine transaminase","BLBBGE_342, BLBBGE_355, BLBBGE_455","isoenzymes","tyrB, aspC, ilvE","transaminase, aspartate transaminase, branched-chain amino acid transaminase","[c] : glu-L + phpyr ↔ akg + phe-L","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:2.6.1.58"]
["R_PIt7","phosphate transport in/out via three Na+ symporter","BLBBGE_368",null,"pit","phosphate sodium symporter","(3) na1[e] + pi[e] ↔ (3) na1[c] + pi[c]","Transport, Extracellular"]
["R_PMEVKx","phosphomevalonate kinase","BLBBGE_085",null,"mvaK/mvaK2","mevalonate kinase","[c] : 5pmev + atp → 5dpmev + adp","Cell Envelope Biosynthesis","EC:2.7.4.2"]
["R_PNTK","pantothenate kinase","BLBBGE_132",null,"coaA","pantothenate kinase","[c] : atp + pnto-R → 4ppan + adp + h","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.1.33","Mg2+"]
["R_PPA","inorganic diphosphatase","BLBBGE_010",null,"ppa","inorganic pyrophosphatase","[c] : h2o + ppi → h + (2) pi","Anaplerotic reactions","EC:3.6.1.1","Mg2+"]
["R_PPCK","phosphoenolpyruvate carboxykinase","BLBBGE_077",null,"pckA","phosphoenolpyruvate carboxykinase (ATP) ","[c] : atp + oaa → adp + co2 + pep","Anaplerotic reactions","EC:4.1.1.49","Mg2+"]
["R_PPND","prephenate dehydrogenase","BLBBGE_343",null,"tyrA","prephenate dehydrogenase ","[c] : nad + pphn → 34hpp + co2 + nadh","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC 1.3.1.12"]
["R_PPNDH","prephenate dehydratase","BLBBGE_341",null,"pheA","prephenate dehydratase ","[c] : h + pphn → co2 + h2o + phpyr","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.2.1.51"]
["R_PPTGS_Bge","Peptidoglycan subunit synthesis","BLBBGE_284",null,"mrcA","peptidoglycan synthetase; fused penicillin-binding protein 1a: murein transglycosylase/murein transpeptidase","[c] : uaagmda → h + peptido_Bge + udcpdp","Cell Envelope Biosynthesis","EC:2.4.1.129"]
["R_PRAGSr","phosphoribosylglycinamide synthase","BLBBGE_479",null,"purD","phosphoribosylamine-glycine ligase","[c] : atp + gly + pram → adp + gar + h + pi","Purine and Pyrimidine Biosynthesis","EC:6.3.4.13","Mg2+"]
["R_PRAIi","phosphoribosylanthranilate isomerase (irreversible)","BLBBGE_425",null,"trpFB","bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta","[c] : pran → 2cpr5p","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:5.3.1.24"]
["R_PRAIS","phosphoribosylaminoimidazole synthase","BLBBGE_482",null,"purM","phosphoribosylformylglycinamidine cyclo-ligase","[c] : atp + fpram → adp + air + (2) h + pi","Purine and Pyrimidine Biosynthesis","EC:6.3.3.1","K+, Mg2+"]
["R_PRAMPC","phosphoribosyl-AMP cyclohydrolase","BLBBGE_440",null,"hisI","bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase protein ","[c] : h2o + prbamp → prfp","Histidine Metabolism","EC:3.5.4.19 "]
["R_PRASCS","phosphoribosylaminoimidazolesuccinocarboxamide synthase","BLBBGE_484",null,"purC","phosphoribosylaminoimidazolesuccinocarboxamide synthase ","[c] : 5aizc + asp-L + atp → 25aics + adp + h + pi","Purine and Pyrimidine Biosynthesis","EC:6.3.2.6"]
["R_PRATPP","phosphoribosyl-ATP pyrophosphatase","BLBBGE_440",null,"hisI","bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase protein ","[c] : h2o + prbatp → h + ppi + prbamp","Histidine Metabolism","EC:3.6.1.31"]
["R_PRFGS","phosphoribosylformylglycinamidine synthase","BLBBGE_486",null,"purL","phosphoribosylformylglycinamidine synthase","[c] : atp + fgam + gln-L + h2o → adp + fpram + glu-L + h + pi","Purine and Pyrimidine Biosynthesis","EC:6.3.5.3","Mg2+"]
["R_PRMICIi","1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (irreversible)","BLBBGE_438",null,"hisA","1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase","[c] : prfp → prlp","Histidine Metabolism","EC:5.3.1.16"]
["R_PRPPS","phosphoribosylpyrophosphate synthetase","BLBBGE_497",null,"prsA","ribose-phosphate diphosphokinase","[c] : atp + r5p → amp + h + prpp","Histidine Metabolism","EC:2.7.6.1"]
["R_PSCVT","3-phosphoshikimate 1-carboxyvinyltransferase","BLBBGE_406",null,"aroA","3-phosphoshikimate 1-carboxyvinyltransferase ","[c] : pep + skm5p → 3psme + pi","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:2.5.1.19"]
["R_PSD_Bge","Phosphatidylserine decarboxylase","BLBBGE_225",null,"psd","phosphatidylserine decarboxylase ","[c] : h + (0.02) ps_Bge → co2 + (0.02) pe_Bge","Membrane Lipid Metabolism","EC:4.1.1.65"]
["R_PSERT","phosphoserine transaminase","BLBBGE_144, BLBBGE_428","isoenzymes","serC","phosphoserine transaminase","[c] : 3php + glu-L ↔ akg + pser-L","Glycine and Serine Metabolism","EC:2.6.1.52"]
["R_PSSA_Bge","Phosphatidylserine syntase","BLBBGE_532",null,"pssA","CDP-diacylglycerol--serine O-phosphatidyltransferase","[c] : (0.02) cdpdag_Bge + ser-L → cmp + h + (0.02) ps_Bge ","Membrane Lipid Metabolism","EC:2.7.8.8"]
["R_PTPATi","pantetheine-phosphate adenylyltransferase","BLBBGE_286",null,"coaD","pantetheine-phosphate adenylyltransferase","[c] : atp + h + pan4p → dpcoa + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.7.3","Mg2+"]
["R_PUNP1","purine-nucleoside phosphorylase (Adenosine)","BLBBGE_377",null,"pndA","purine nucleoside phosphorylase","[c] : adn + pi ↔ ade + r1p","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_PUNP2","purine-nucleoside phosphorylase (Deoxyadenosine)","BLBBGE_377",null,"pndA","purine nucleoside phosphorylase","[c] : dad-2 + pi ↔ 2dr1p + ade","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_PUNP3","purine-nucleoside phosphorylase (Guanosine)","BLBBGE_377",null,"pndA","purine nucleoside phosphorylase","[c] : gsn + pi ↔ gua + r1p","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_PUNP4","purine-nucleoside phosphorylase (Deoxyguanosine)","BLBBGE_377",null,"pndA","purine nucleoside phosphorylase","[c] : dgsn + pi ↔ 2dr1p + gua","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_PUNP5","purine-nucleoside phosphorylase (Inosine)","BLBBGE_377",null,"pndA","purine nucleoside phosphorylase","[c] : ins + pi ↔ hxan + r1p","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_PUNP6","purine-nucleoside phosphorylase (Deoxyinosine)","BLBBGE_377",null,"pndA","purine nucleoside phosphorylase","[c] : din + pi ↔ 2dr1p + hxan","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_PUNP7","purine-nucleoside phosphorylase (Xanthosine)","BLBBGE_377",null,"pndA","purine nucleoside phosphorylase","[c] : pi + xtsn ↔ r1p + xan","Nucleotide Salvage Pathway","EC:2.4.2.1"]
["R_PYAM5PO","pyridoxamine 5&apos;-phosphate oxidase","BLBBGE_050",null,"pdxH","pyridoxamine 5'-phosphate oxidase","[c] : h2o + o2 + pyam5p → h2o2 + nh4 + pydx5p","Cofactor and Prosthetic Group Biosynthesis","EC:1.4.3.5"]
["R_RBFK","riboflavin kinase","BLBBGE_072",null,"ribF, yaaC","bifunctional riboflavin kinase/FAD synthetase ","[c] : atp + ribflv --> adp + fmn + h","Cofactor and Prosthetic Group Biosynthesis","EC:2.7.1.26; 2.7.7.2"]
["R_RBFSa","riboflavin synthase","BLBBGE_076",null,"ribE (also ribC)","riboflavin synthase subunit alpha","[c] : 4r5au + db4p → dmlz + (2) h2o + pi","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.9"]
["R_RBFSb","riboflavin synthase","BLBBGE_547",null,"ribH","bifunctional riboflavin synthase subunit beta","[c] : (2) dmlz → 4r5au + ribflv","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.9"]
["R_RNDR1","ribonucleoside-diphosphate reductase (ADP)","BLBBGE_310, BLBBGE_p006","Enzyme complex","nrdA, nrdF","ribonucleoside-diphosphate reductase subunit alpha; ribonucleotide-diphosphate reductase beta subunit","[c] : adp + trdrd → dadp + h2o + trdox","Nucleotide Salvage Pathway","EC:1.17.4.1","Mg2+"]
["R_RNDR2","ribonucleoside-diphosphate reductase (GDP)","BLBBGE_310, BLBBGE_p006","Enzyme complex","nrdA, nrdF","ribonucleoside-diphosphate reductase subunit alpha; ribonucleotide-diphosphate reductase beta subunit","[c] : gdp + trdrd → dgdp + h2o + trdox","Nucleotide Salvage Pathway","EC:1.17.4.1","Mg2+"]
["R_RNDR3","ribonucleoside-diphosphate reductase (CDP)","BLBBGE_310, BLBBGE_p006","Enzyme complex","nrdA, nrdF","ribonucleoside-diphosphate reductase subunit alpha; ribonucleotide-diphosphate reductase beta subunit","[c] : cdp + trdrd → dcdp + h2o + trdox","Nucleotide Salvage Pathway","EC:1.17.4.1","Mg2+"]
["R_RNDR4","ribonucleoside-diphosphate reductase (UDP)","BLBBGE_310, BLBBGE_p006","Enzyme complex","nrdA, nrdF","ribonucleoside-diphosphate reductase subunit alpha; ribonucleotide-diphosphate reductase beta subunit","[c] : trdrd + udp → dudp + h2o + trdox","Nucleotide Salvage Pathway","EC:1.17.4.1","Mg2+"]
["R_RPE","ribulose 5-phosphate 3-epimerase","BLBBGE_347",null,"rpe","ribulose-phosphate 3-epimerase","[c] : ru5p-D ↔ xu5p-D","Pentose Phosphate Pathway","EC:5.1.3.1"]
["R_RPI","ribose-5-phosphate isomerase","BLBBGE_295",null,"rpiB","ribose 5-phosphate isomerase B","[c] : r5p ↔ ru5p-D","Pentose Phosphate Pathway","EC:5.3.1.6"]
["R_SADT2","Sulfate adenyltransferase","BLBBGE_274, BLBBGE_275","Enzyme complex","cysD, cysN","sulfate adenylyltransferase subunit 2, sulfate adenylyltransferase subunit 1","[c] : atp + gtp + h2o + so4 ↔ aps + gdp + pi + ppi","Cysteine Metabolism","EC:2.7.7.4"]
["R_SDPDS","succinyl-diaminopimelate desuccinylase","BLBBGE_320",null,"argE (encoding of a protein also with function similar to DapE)","Acting here as Succinyl-diaminopimelate desuccinylase","[c] : h2o + sl26da → 26dap-LL + succ","Threonine and Lysine Metabolism","EC:3.5.1.18","Zn2+, Co2+"]
["R_SDPTA","succinyldiaminopimelate transaminase","BLBBGE_315, BLBBGE_623","isoenzymes","argD (with functions associated to dapC gen in this reaction)","acetylornithine transaminase (BLBBGE_315); bifunctional acetylornithine transaminase/N-succinyldiaminopimelate aminotransferase (BLBBGE_623)","[c] : sl2a6o + glu-L ↔ sl26da + akg","Threonine and Lysine Metabolism","EC:2.6.1.17"]
["R_SEPHCHC","2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase","BLBBGE_056",null,"menD","bifunctional 2-oxoglutarate decarboxylase/2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase","[c] : ichor + akg + (2) h → co2 + 5ephchc","Cofactor and Prosthetic Group Biosynthesis","EC:4.1.1.71,  2.2.1.9","Mg2+, Mn2+ (cofactors);thiamine diphosphate ( prostetic group)"]
["R_SERAT","serine O-acetyltransferase","BLBBGE_276",null,"cysE","serine O-acetyltransferase","[c] : accoa + ser-L ↔ acser + coa","Cysteine Metabolism","EC:2.3.1.30"]
["R_SHCHC","2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase","BLBBGE_131",null,"menH (yfbB )","2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase","[c] : 5ephchc → 2shchc + pyr","Cofactor and Prosthetic Group Biosynthesis","EC:4.2.99.20"]
["R_SHCHCS2","2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase","BLBBGE_056",null,"menD","bifunctional 2-oxoglutarate decarboxylase/2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase","[c] : ichor + ssaltpp → 2shchc + pyr + thmpp","Cofactor and Prosthetic Group Biosynthesis","EC:2.2.1.9","Mg2+"]
["R_SHK3Dr","shikimate dehydrogenase","BLBBGE_142",null,"ydiB","shikimate dehydrogenase","[c] : 3dhsk + h + nadph ↔ nadp + skm","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:1.1.1.25"]
["R_SHKK","shikimate kinase","BLBBGE_430",null,"aroK","shikimate kinase ","[c] : atp + skm → adp + h + skm5p","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:2.7.1.71","Mg2+"]
["R_SHSL1","O-succinylhomoserine lyase (L-cysteine)","BLBBGE_568",null,"metBC","cystathionine gamma-synthase/cystathionine beta-lyase","[c] : cys-L + suchms → cyst-L + h + succ","Methionine Metabolism","EC 4.2.99.9 (transferred to EC 2.5.1.48)"]
["R_SPODM","superoxide dismutase","BLBBGE_293",null,"sodA","superoxide dismutase (Mn/Fe) ","[c] : (2) h + (2) o2s → h2o2 + o2","Unassigned","EC:1.15.1.1","Mn2+"]
["R_SUCBZL","o-succinylbenzoate-CoA ligase","BLBBGE_271 ",null,"menE","O-succinylbenzoate-CoA ligase","[c] : atp + coa + sucbz → amp + ppi + sbzcoa","Cofactor and Prosthetic Group Biosynthesis","EC:6.2.1.26","Mg2+"]
["R_SUCBZS","O-succinylbenzoate-CoA synthase","BLBBGE_270",null,"menC","o-succinylbenzoyl-CoA synthase","[c] : 2shchc → h2o + sucbz","Cofactor and Prosthetic Group Biosynthesis","EC:4.2.1.-","Mg2+"]
["R_SUCCt2_2","succinate transport via proton symport (2 H)","BLBBGE_358",null,"gltP (but functions here as dctA)","glutamate/aspartate:proton symporter","(2) h[e] + succ[e] → (2) h[c] + succ[c]","Transport, Extracellular"]
["R_SUCD1i","succinate dehydrogenase","BLBBGE_151, BLBBGE_152, BLBBGE_153","Enzyme complex","sdhC, sdhA, sdhB","succinate dehydrogenase cytochrome b subunit, succinate dehydrogenase flavoprotein subunit, succinate dehydrogenase iron-sulfur subunit","[c] : fad + succ ↔ fadh2 + fum","TCA cycle ","EC:1.3.99.1 (EC:1.3.5.1 for each subunit)"]
["R_SUCD4","succinate dehydrogenase","BLBBGE_151, BLBBGE_152, BLBBGE_153","Enzyme complex","sdhC, sdhA, sdhB","succinate dehydrogenase cytochrome b subunit, succinate dehydrogenase flavoprotein subunit, succinate dehydrogenase iron-sulfur subunit","[c] : fadh2 + mqn8 ↔ fad + mql8","Oxidative Phosphorylation","EC:1.3.99.1 (EC:1.3.5.1 for each subunit)"]
["R_SUCOAS","succinyl-CoA synthetase (ADP-forming)","BLBBGE_039, BLBBGE_591","Enzyme complex","sucD, sucC","succinyl-CoA synthetaseNAD(P)-binding alpha subunit, succinyl-CoA ligase (ADP-forming) subunit beta respectively ","[c] : atp + coa + succ ↔ adp + pi + succoa","TCA cycle ","EC:6.2.1.5"]
["R_SULR","sulfite reductase (NADPH2)","BLBBGE_279, BLBBGE_280","Enzyme complex","cysJ, cysI","sulfite reductase (NADPH) flavoprotein subunit alpha, sulfite reductase (NADPH) hemoprotein subunit beta","[c] : (5) h + (3) nadph + so3 ↔ (3) h2o + h2s + (3) nadp","Cysteine Metabolism","EC:1.8.1.2"]
["R_TALA","transaldolase","BLBBGE_213",null,"talA or talB","translaldolase ","[c] : g3p + s7p  ↔ e4p + f6p","Pentose Phosphate Pathway","EC:2.2.1.2"]
["R_THDPS","tetrahydrodipicolinate succinylase","BLBBGE_467",null,"dapD","2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase ","[c] : h2o + succoa + thdp ↔ coa + sl2a6o","Threonine and Lysine Metabolism","EC:2.3.1.117"]
["R_THRD_L","L-threonine deaminase","BLBBGE_553",null,"ilvA","threonine ammonia-lyase","[c] : thr-L → 2obut + nh4","Valine, Leucine, and Isoleucine Metabolism","EC:4.3.1.19"]
["R_THRS","threonine synthase","BLBBGE_499",null,"thrC","threonine synthase ","[c] : h2o + phom → pi + thr-L","Threonine and Lysine Metabolism","EC:4.2.3.1"]
["R_TKT1","transketolase","BLBBGE_403, BLBBGE_404","Enzyme complex",null,"transketolase N-terminal subunit, transketolase C-terminal subunit ","[c] : r5p + xu5p-D ↔ g3p + s7p","Pentose Phosphate Pathway","EC:2.2.1.1","tktA: Cofactors: Mg2+, Mn2+ "]
["R_TKT2","transketolase","BLBBGE_403, BLBBGE_404","Enzyme complex",null,"transketolase N-terminal subunit, transketolase C-terminal subunit ","[c] : e4p + xu5p-D ↔ f6p + g3p","Pentose Phosphate Pathway","EC:2.2.1.1","tktA: Cofactors: Mg2+, Mn2+ "]
["R_TMDPK","thiamine diphosphokinase","BLBBGE_618",null,"thiN","thiamine diphosphokinase","[c] : atp + thm → amp + h + thmpp","Thiamine Metabolism","EC:2.7.6.2"]
["R_TMDS","thymidylate synthase","BLBBGE_498",null,"thyA","thymidylate synthase","[c] : dump + mlthf → dhf + dtmp","Nucleotide Salvage Pathway","EC:2.1.1.45","Mg2+"]
["R_TPI","triose-phosphate isomerase","BLBBGE_104",null,"tpiA","triose-phosphate isomerase ","[c] : dhap ↔ g3p","Glycolysis/Gluconeogenesis","EC:5.3.1.1"]
["R_TRDR","thioredoxin reductase (NADPH)","BLBBGE_045",null,"trxB","thioredoxin reductase, FAD/NAD(P)-binding ","[c] : h + nadph + trdox → nadp + trdrd","Oxidative phosphorylation","EC:1.8.1.9"]
["R_TRIOK","triokinase","BLBBGE_459",null,"glpK","triokinase","[c] : atp + glyald → g3p + adp + h","Fructose and Mannose Metabolism","EC:2.7.1.28","Mg2+, Alternative Cofactors for Mg2+: Mn2+ "]
["R_TRPS1","tryptophan synthase (indoleglycerol phosphate)","BLBBGE_425, BLBBGE_426","Enzyme complex","trpFB, trpA","bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta, tryptophan synthase subunit alpha","[c] : 3ig3p + ser-L → g3p + h2o + trp-L","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.2.1.20"]
["R_TRPS2","tryptophan synthase (indole)","BLBBGE_425, BLBBGE_426","Enzyme complex","trpFB, trpA","bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta, tryptophan synthase subunit alpha","[c] : indole + ser-L → h2o + trp-L","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.2.1.20"]
["R_TRPS3","tryptophan synthase (indoleglycerol phosphate)","BLBBGE_425, BLBBGE_426","Enzyme complex","trpFB, trpA","bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta, tryptophan synthase subunit alpha","[c] : 3ig3p → g3p + indole","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:4.2.1.20"]
["R_TYRTA","tyrosine transaminase","BLBBGE_342, BLBBGE_355","isoenzymes","tyrB, aspC","transaminase, aspartate transaminase","[c] : 34hpp + glu-L ↔ akg + tyr-L","Tyrosine, Tryptophan, and Phenylalanine Metabolism","EC:2.6.1.5","Cell Envelope Biosynthesis"]
["R_UAAGDS","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase","BLBBGE_390",null,"murE","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase","[c] : 26dap-M + atp + uamag → adp + h + pi + ugmd","Cell Envelope Biosynthesis","EC:6.3.2.13"]
["R_UAGCVT","UDP-N-acetylglucosamine 1-carboxyvinyltransferase","BLBBGE_135",null,"murA","UDP-N-acetylglucosamine 1-carboxyvinyltransferase","[c] : pep + uacgam → pi + uaccg","Cell Envelope Biosynthesis","EC:2.5.1.7"]
["R_UAGDP","UDP-N-acetylglucosamine diphosphorylase","BLBBGE_605",null,"galU","UTP-glucose-1-phosphate uridylyltransferase","[c] : acgam1p + h + utp -> ppi + uacgam","Cell Envelope Biosynthesis","EC:2.7.7.23"]
["R_UAGPT3","UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase","BLBBGE_386",null,"murG","undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase ","[c] : uacgam + uagmda → h + uaagmda + udp","Cell Envelope Biosynthesis","EC:2.4.1.227"]
["R_UAMAGS","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase","BLBBGE_388",null,"murD","UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase ","[c] : atp + glu-D + uama → adp + h + pi + uamag","Cell Envelope Biosynthesis","EC:6.3.2.9"]
["R_UAMAS","UDP-N-acetylmuramoyl-L-alanine synthetase","BLBBGE_385",null,"murC","UDP-N-acetylmuramate-L-alanine ligase","[c] : ala-L + atp + uamr → adp + h + pi + uama","Cell Envelope Biosynthesis","EC:6.3.2.8","Mg2+"]
["R_UAPGR","UDP-N-acetylenolpyruvoylglucosamine reductase","BLBBGE_376",null,"murB","UDP-N-acetylmuramate dehydrogenase","[c] : h + nadph + uaccg → nadp + uamr","Cell Envelope Biosynthesis","EC:1.1.1.158"]
["R_UDCPDP","undecaprenyl-diphosphatase","BLBBGE_362",null,"uppP","undecaprenyl-diphosphatase","[c] : h2o + udcpdp → h + pi + udcpp","Cell Envelope Biosynthesis","EC: 3.6.1.27","Ca2+, Cd2+, Cu2+, Fe2+, Mg2+, Mn2+"]
["R_UDCPDPS","Undecaprenyl diphosphate synthase","BLBBGE_087",null,"ispU, rth,  uppS, yaeS","undecaprenyl pyrophosphate synthase ","[c] : frdp + (8) ipdp → (8) ppi + udcpdp","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.31"]
["R_UGMDDS","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase","BLBBGE_100",null,"murF, mra","UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase","[c] : alaala + atp + ugmd → adp + h + pi + ugmda","Cell Envelope Biosynthesis","EC:6.3.2.10"]
["R_UHGADA","UDP-3-O-acetylglucosamine deacetylase","BLBBGE_037",null,"lpxC","bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase","[c] : h2o + u3aga → ac + u3hga","Cell Envelope Biosynthesis","EC:3.5.1.-"]
["R_UMPK","UMP kinase","BLBBGE_120, BLBBGE_058","isoenzymes","pyrH, smbA, umk, cmk","UMP kinase; cytidine monophosphate kinase ","[c] : atp + ump ↔ adp + udp","Nucleotide Salvage Pathway","EC:2.7.4.-"]
["R_UPP3S","uroporphyrinogen-III synthase","BLBBGE_290, BLBBGE_576","isoenzymes","hemD","uroporphyrinogen-III synthase","[c] : hmbil → h2o + uppg3","Cofactor and Prosthetic Group Biosynthesis","EC:4.2.1.75"]
["R_UREA","urease","BLBBGE_502, BLBBGE_503","Enzyme complex","ureAB, ureC","urease subunit beta/gamma, urease subunit alpha","[c] : (2) h + h2o + urea → co2 + (2) nh4","Purine metabolism","EC:3.5.1.5","Ni2+"]
["R_UREAt","Urea transport via facilitate diffusion","BLBBGE_460",null,"glpF","putative glycerol diffusion channel","urea[e] ↔ urea[c]","Transport, Extracellular"]
["R_URIDK2r","uridylate kinase (dUMP)","BLBBGE_120",null,"pyrH, smbA,  umk","UMP kinase ","[c] : atp + dump ↔ adp + dudp","Nucleotide Salvage Pathway","EC:2.7.4.22"]
["R_URIK2","uridine kinase (GTP:Uridine)","BLBBGE_535",null,"udk","uridine kinase","[c] : gtp + uri → gdp + h + ump","Nucleotide Salvage Pathway","EC:2.7.1.48"]
["R_VALTA","valine transaminase","BLBBGE_455",null,"ilvE","branched-chain amino acid transaminase","[c] : 3mob + glu-L ↔ akg + val-L ","Valine, Leucine, and Isoleucine Metabolism","EC:2.6.1.42"]
[]
["Biomass Reaction"]
["Equation: [c] : (0.488) ala-L + (0.001) amp + (0.281) arg-L + (0.229) asn-L + (0.229) asp-L + (45.7318) atp + (0.000006) coa + (0.126) ctp + (0.087) cys-L + (0.0365) datp + (0.0135) dctp + (0.0135) dgtp + (0.0365) dttp + (0.00001) fad + (0.25) gln-L + (0.25) glu-L + (0.582) gly + (0.203) gtp + (45.5608) h2o + (0.09) his-L + (0.276) ile-L + (0.428) leu-L + (0.326) lys-L + (0.146) met-L + (0.00215) nad + (0.00005) nadh + (0.00013) nadp + (0.0004) nadph + (0.001935) pe_Bge + (0.0276) peptido_Bge + (0.176) phe-L + (0.21) pro-L + (0.000052) ps_Bge + (0.035) ptrc + (0.205) ser-L + (0.000223) thf + (0.000223) thmpp[c] + (0.241) thr-L + (0.054) trp-L + (0.131) tyr-L + (0.136) utp + (0.402) val-L --> (45.5608) adp + (45.56035) h + (45.5628) pi + (0.7302) ppi"]

{"sheet":"Reactions not associated to gen","index":1,"n_rows":76,"n_cols":5,"rows_kept":76,"flags":["formulas_cached_only"]}
["Abbreviation","Official name","Equation (note [c] and [e] at the beginning refer to the compartment the reaction takes place in the cytoplasm and extracellular environment, respectively)","Subsystem","Protein class description"]
["R_ACGS","N-acetylglutamate synthase","[c] : accoa + glu-L → acglu + coa + h","Arginine and Proline Metabolism","EC:2.3.1.1"]
["R_ACt2r","acetate reversible transport via proton symport","ac[e] + h[e] ↔ ac[c] + h[c]","Transport, Extracellular"]
["R_ADA","Adenosine deaminase","[c] : adn + h + h2o → ins + nh4","Nucleotide Salvage Pathway","EC:3.5.4.4"]
["R_ADD","adenine deaminase (reaction also occures spontaneously)","[c] : ade + h + h2o → hxan + nh4","Nucleotide Salvage Pathway","EC:3.5.4.2"]
["R_AHC","Adenosylhomocysteinase","[c] : ahcys + h2o ↔ adn + hcys-L","Methionine Metabolism","EC:3.3.1.1"]
["R_AIRC2","Phosphoribosylaminoimidazole carboxylase","[c] : air + atp + hco3 → 5caiz + adp + h + pi","Purine and Pyrimidine Biosynthesis"]
["R_AKGt2r","2-oxoglutarate reversible transport via symport","akg[e] + h[e] ↔ akg[c] + h[c]","Transport, Extracellular"]
["R_ALAR","Alanine racemase","[c] : ala-L ↔ ala-D","Alanine and Aspartate Metabolism","EC:5.1.1.1"]
["R_ALAt2r","L-alanine reversible transport via proton symport","ala-L[e] + h[e] ↔ ala-L[c] + h[c]","Putative Transporters"]
["R_ALATA_L2","alanine transaminase","[c] : ala-L + pydx5p → pyam5p + pyr","Cofactor and Prosthetic Group Biosynthesis","EC:2.1.2.1"]
["R_ARGabc","L-arginine transport via ABC system","arg-L[e] + atp[c] + h2o[c] → adp[c] + arg-L[c] + h[c] + pi[c]","Transport, Extracellular"]
["R_ASNt2r","L-asparagine reversible transport via proton symport","asn-L[e] + h[e] ↔ asn-L[c] + h[c]","Transport, Extracellular"]
["R_BPNT","3&apos;,5&apos;-bisphosphate nucleotidase","[c] : h2o + pap → amp + pi","Cysteine Metabolism"]
["R_CMPN","CMP nucleosidase","[c] : cmp + h2o → csn + r5p","Nucleotide Salvage Pathway","EC:3.2.2.10"]
["R_CO2t","CO2 transporter via diffusion","co2[e] ↔ co2[c]","Transport, Extracellular"]
["R_CYSabc","L-cysteine transport via ABC system","atp[c] + cys-L[e] + h2o[c] → adp[c] + cys-L[c] + h[c] + pi[c]","Transport, Extracellular"]
["R_DADA","Deoxyadenosine deaminase","[c] : dad-2 + h + h2o → din + nh4","Nucleotide Salvage Pathway","EC:3.5.4.4"]
["R_dhorSt","S-Dihydroorotate transporter","dhor-S[e] ↔ dhor-S[c]","Transport, Extracellular"]
["R_DMATT","dimethylallyltranstransferase","[c] : dmpp + ipdp → grdp + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.1"]
["R_DNMPPA","Dihydroneopterin monophosphate dephosphorylase","[c] : dhpmp + h2o → dhnpt + pi","Cofactor and Prosthetic Group Biosynthesis"]
["R_DTMPK","dTMP kinase","[c] : atp + dtmp ↔ adp + dtdp","Nucleotide Salvage Pathway","EC:2.7.4.9"]
["R_DURIK1","deoxyuridine kinase (ATP:Deoxyuridine)","[c] : atp + duri → adp + dump + h","Nucleotide Salvage Pathway","EC:2.7.1.21"]
["R_DXPS","1-deoxy-D-xylulose 5-phosphate synthase","[c] : g3p + h + pyr →  co2 + dxyl5p","Cofactor and Prosthetic Group Biosynthesis","EC:2.2.1.7"]
["R_FORt","formate transport via diffusion","for[e] ↔ for[c]","Transport, Extracellular"]
["R_G5SADs","L-glutamate 5-semialdehyde dehydratase (spontaneous)","[c] : glu5sa → 1pyr5c + h + h2o","Arginine and Proline Metabolism"]
["R_GCALDD","Glycolaldehyde dehydrogenase","[c] : gcald + h2o + nad → glyclt + (2) h + nadh","Folate Metabolism"]
["R_GLNabc","L-glutamine transport via ABC system","atp[c] + gln-L[e] + h2o[c] → adp[c] + gln-L[c] + h[c] + pi[c]","Transport, Extracellular"]
["R_GLYCLTt2r","glycolate transport via proton symport, reversible","glyclt[e] + h[e] ↔ glyclt[c] + h[c]","Transport, Extracellular"]
["R_GRTT","geranyltranstransferase","[c] : grdp + ipdp → frdp + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:2.5.1.10"]
["R_GUAD","guanine deaminase","[c] : gua + h + h2o → nh4 + xan","Nucleotide Salvage Pathway","EC:3.5.4.3"]
["R_H2Ot","H2O transport via diffusion","h2o[e] ↔ h2o[c]","Transport, Extracellular"]
["R_HCO3E","HCO3 equilibration reaction","[c] : co2 + h2o ↔ h + hco3",null,"EC:4.2.1.1"]
["R_HISabc","L-histidine transport via ABC system","atp[c] + h2o[c] + his-L[e] → adp[c] + h[c] + his-L[c] + pi[c]","Transport, Extracellular"]
["R_HSST","homoserine O-succinyltransferase","[c] : hom-L + succoa → coa + suchms","Methionine Metabolism","EC:2.3.1.46"]
["R_ILEabc","L-isoleucine transport via ABC system","atp[c] + h2o[c] + ile-L[e] → adp[c] + h[c] + ile-L[c] + pi[c]","Transport, Extracellular"]
["R_LEUabc","L-leucine transport via ABC system","atp[c] + h2o[c] + leu-L[e] → adp[c] + h[c] + leu-L[c] + pi[c]","Transport, Extracellular"]
["R_LYSabc","L-lysine transport via ABC system","atp[c] + h2o[c] + lys-L[e] → adp[c] + h[c] + lys-L[c] + pi[c]","Transport, Extracellular"]
["R_METabc","L-methionine transport via ABC system","atp[c] + h2o[c] + met-L[e] → adp[c] + h[c] + met-L[c] + pi[c]","Transport, Extracellular"]
["R_NACUP","Nicotinic acid uptake","nac[e] → nac[c]","Transport, Extracellular"]
["R_NAt3_1","sodium proton antiporter (H:NA is 1:1)","h[e] + na1[c] ↔ h[c] + na1[e]","Transport, Extracellular"]
["R_NH4t","ammonia reversible transport","nh4[e] ↔ nh4[c]","Transport, Extracellular"]
["R_NTD1","5&apos;-nucleotidase (IMP)","[c] : dump + h2o → duri + pi","Nucleotide Salvage Pathway","EC:3.1.3.5"]
["R_NTD10","5&apos;-nucleotidase (XMP)","[c] : h2o + xmp → pi + xtsn","Nucleotide Salvage Pathway","EC:3.1.3.5"]
["R_NTD11","5&apos;-nucleotidase (IMP)","[c] : h2o + imp → ins + pi","Nucleotide Salvage Pathway","EC:3.1.3.5"]
["R_NTD2","5&apos;-nucleotidase (UMP)","[c] : h2o + ump → pi + uri","Nucleotide Salvage Pathway","EC:3.1.3.5"]
["R_NTD3","5&apos;-nucleotidase (dCMP)","[c] : dcmp + h2o → dcyt + pi","Nucleotide Salvage Pathway","EC:3.1.3.5"]
["R_NTD4","5&apos;-nucleotidase (CMP)","[c] : cmp + h2o → cytd + pi","Nucleotide Salvage Pathway","EC:3.1.3.5"]
["R_NTD5","5&apos;-nucleotidase (dTMP)","[c] : dtmp + h2o → pi + thymd","Nucleotide Sugar Metabolism","EC:3.1.3.5"]
["R_NTD6","5&apos;-nucleotidase (dAMP)","[c] : damp + h2o → dad-2 + pi","Nucleotide Sugar Metabolism","EC:3.1.3.5"]
["R_NTD7","5&apos;-nucleotidase (AMP)","[c] : amp + h2o → adn + pi","Nucleotide Sugar Metabolism","EC:3.1.3.5"]
["R_NTD8","5&apos;-nucleotidase (dGMP)","[c] : dgmp + h2o → dgsn + pi","Nucleotide Sugar Metabolism","EC:3.1.3.5"]
["R_NTD9","5&apos;-nucleotidase (GMP)","[c] : gmp + h2o → gsn + pi","Nucleotide Sugar Metabolism","EC:3.1.3.5"]
["R_O2t","o2 transport (diffusion)","o2[e] ↔ o2[c]","Transport, Extracellular"]
["R_PERD","Erythronate 4-phosphate (4per) dehydrogenase","[c] : 4per + nad ↔ h + nadh + ohpb","Cofactor and Prosthetic Group Biosynthesis","EC:1.1.1.-"]
["R_PHEt2r","L-phenylalanine reversible transport via proton symport","h[e] + phe-L[e] ↔ h[c] + phe-L[c]","Transport, Extracellular"]
["R_PMDPHT","pyrimidine phosphatase","[c] : 5aprbu + h2o → 4r5au + pi","Cofactor and Prosthetic Group Biosynthesis"]
["R_PNTOt4","Pantothenate sodium symporter","na1[e] + pnto-R[e] → na1[c] + pnto-R[c]","Transport, Extracellular"]
["R_PPBNGt","Phorphobilinogen transport","ppbng[e] ↔ ppbng[c]","Transport, Extracellular"]
["R_PPCDC","phosphopantothenoylcysteine decarboxylase","[c] : 4ppcys + h → co2 + pan4p","Cofactor and Prosthetic Group Biosynthesis","EC:4.1.1.36"]
["R_PPNCL2","phosphopantothenate-cysteine ligase","[c] : 4ppan + ctp + cys-L→ 4ppcys + cmp + h + ppi","Cofactor and Prosthetic Group Biosynthesis","EC:6.3.2.5"]
["R_PROt2r","L-proline reversible transport via proton symport","h[e] + pro-L[e] ↔ h[c] + pro-L[c]","Transport, Extracellular"]
["R_PSP_L","phosphoserine phosphatase (L-serine)","[c] : h2o + pser-L → pi + ser-L","Glycine and Serine Metabolism","EC:3.1.3.3"]
["R_PYDXK","pyridoxal kinase","[c] : atp + pydx --&gt; adp + h + pydx5p","Cofactor and Prosthetic Group Biosynthesis"]
["R_PYDXPP","Pyridoxal 5-phosphate phosphatase","[c] : h2o + pydx5p → pi + pydx","Cofactor and Prosthetic Group Biosynthesis"]
["R_PYRt2r","pyruvate reversible transport via proton symport","h[e] + pyr[e] ↔ h[c] + pyr[c]","Transport, Extracellular"]
["R_SERt4","L-serine via sodium symport","na1[e] + ser-L[e] → na1[c] + ser-L[c]","Transport, Extracellular"]
["R_SULabc","sulfate transport via ABC system","atp[c] + h2o[c] + so4[e] → adp[c] + h[c] + pi[c] + so4[c]","Transport, Extracellular"]
["R_THMabc","thiamine transport via ABC system","atp[c] + h2o[c] + thm[e] → adp[c] + h[c] + pi[c] + thm[c]","Transport, Extracellular"]
["R_THRabc","L-threonine transport via ABC system","atp[c] + h2o[c] + thr-L[e] → adp[c] + h[c] + pi[c] + thr-L[c]","Transport, Extracellular"]
["R_TMDK1","thymidine kinase (ATP:thymidine)","[c] : atp + thymd → adp + dtmp + h","Nucleotide Salvage Pathway","EC:2.7.1.21"]
["R_TMDPP","thymidine phosphorylase","[c] : pi + thymd ↔ 2dr1p + thym","Nucleotide Salvage Pathway","EC:2.4.2.4"]
["R_TRPt2r","L-tryptophan reversible transport via proton symport","h[e] + trp-L[e] ↔ h[c] + trp-L[c]","Transport, Extracellular"]
["R_TYRt2r","L-tyrosine reversible transport via proton symport","h[e] + tyr-L[e] ↔ h[c] + tyr-L[c]","Transport, Extracellular"]
["R_UAGAAT","UDP-N-acetylglucosamine acyltransferase","[c] : 3hmrsACP + uacgam ↔ ACP + u3aga","Cell Envelope Biosynthesis","EC:2.3.1.129"]
["R_VALabc","L-valine transport via ABC system","atp[c] + h2o[c] + val-L[e] → adp[c] + h[c] + pi[c] + val-L[c]","Transport, Extracellular"]

{"sheet":"Exchange_fluxes","index":2,"n_rows":179,"n_cols":7,"rows_kept":179,"merged":[[0,2,0,3]],"flags":["formulas_cached_only"]}
[null,null,"Constraints on Exchange Fluxes"]
["Abbreviation","Equation","Lower Bound","Upper Bound"]
["EX_nh4[e]","[e]nh4 <==>",0,{"v":1e+30,"d":"1.00E+30"}]
["EX_akg[e]","[e]akg <==>","Varied",0]
["EX_o2[e]","[e]o2 <==>","Varied",0,"*"]
["EX_co2[e]","[e]co2 <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_fe2[e]","[e]fe2 <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_h2o[e]","[e]h2o <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_h[e]","[e]h <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_k[e]","[e]k <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_na1[e]","[e]na1 <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_pi[e]","[e]pi <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_so4[e]","[e]so4 <==>",-1e+30,{"v":1e+30,"d":"1.00E+30"}]
["EX_ac[e]","[e]ac <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_ala-L[e]","[e]ala-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_arg-L[e]","[e]arg-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_asn-L[e]","[e]asn-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_asp-L[e]","[e]asp-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_cys-L[e]","[e]cys-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_dhor-S[e]","[e]dhor-S <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_for[e]","[e]for <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_fru[e]","[e]fru <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_fum[e]","[e]fum <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_gln-L[e]","[e]gln-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_glu-L[e]","[e]glu-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_gly[e]","[e]gly <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_glyald[e]","[e]glyald <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_glyc[e]","[e]glyc <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_glyclt[e]","[e]glyclt <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_his-L[e]","[e]his-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_ile-L[e]","[e]ile-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_leu-L[e]","[e]leu-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_lys-L[e]","[e]lys-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_mal-L[e]","[e]mal-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_met-L[e]","[e]met-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_nac[e]","[e]nac <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_phe-L[e]","[e]phe-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_pnto-R[e]","[e]pnto-R <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_ppbng[e]","[e]ppbng <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_pro-L[e]","[e]pro-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_pyr[e]","[e]pyr <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_ser-L[e]","[e]ser-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_succ[e]","[e]succ <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_thm[e]","[e]thm <==>","Varied",{"v":1e+30,"d":"1.00E+30"},"*"]
["EX_thr-L[e]","[e]thr-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_trp-L[e]","[e]trp-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_tyr-L[e]","[e]tyr-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_urea[e]","[e]urea <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
["EX_val-L[e]","[e]val-L <==>","Varied",{"v":1e+30,"d":"1.00E+30"}]
[]
["* The lower bound of these exchange reactions can vary but never be set to zero to obtain a viable phenotype in terms of biomass production in FBA simulations"]
{"$rows_empty":127}
[{"$nulls":6},"** This compound is based on the average fatty acid composition in phospholipids. This metabolite really represents 50 copies of the compound and the reactions involving this metabolite have the stoichiometric coefficients appropriately scaled (e.g. 1/50 or 2/50) "]

{"sheet":"Metab Abbr","index":3,"n_rows":365,"n_cols":6,"rows_kept":365,"flags":["formulas_cached_only"]}
["ABBREVIATION","COMPARTMENT","METABOLITE NAME","Molecular Formula","Charge"]
["10fthf","Cytosol","10-Formyltetrahydrofolate","C20H22N7O7",-1]
["13dpg","Cytosol","3-Phospho-D-glyceroyl phosphate","C3H4O10P2",-4]
["1pyr5c","Cytosol","1-Pyrroline-5-carboxylate","C5H6NO2",-1]
["23dhdp","Cytosol","2,3-Dihydrodipicolinate","C7H5NO4",-2]
["23dhmb","Cytosol","(R)-2,3-Dihydroxy-3-methylbutanoate","C5H9O4",-1]
["23dhmp","Cytosol","(R)-2,3-Dihydroxy-3-methylpentanoate","C6H11O4",-1]
["25aics","Cytosol","(S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate","C13H15N4O12P",-4]
["25drapp","Cytosol","2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate","C9H14N5O8P",-2]
["26dap-LL","Cytosol","LL-2,6-Diaminoheptanedioate","C7H14N2O4",0]
["26dap-M","Cytosol","meso-2,6-Diaminoheptanedioate","C7H14N2O4",0]
["2ahbut","Cytosol","(S)-2-Aceto-2-hydroxybutanoate","C6H9O4",-1]
["2cpr5p","Cytosol","1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate","C12H13NO9P",-3]
["2dda7p","Cytosol","2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate","C7H10O10P",-3]
["2dmmq8","Cytosol","2-Demethylmenaquinone 8","C50H70O2",0]
["2dmmql8","Cytosol","2-Demethylmenaquinol 8","C50H72O2",0]
["2dr1p","Cytosol","2-Deoxy-D-ribose 1-phosphate","C5H9O7P",-2]
["2ippm","Cytosol","2-Isopropylmaleate","C7H8O4",-2]
["2obut","Cytosol","2-Oxobutanoate","C4H5O3",-1]
["2ombzl","Cytosol","2-Octaprenyl-6-methoxy-1,4-benzoquinol","C47H72O3",0]
["2ommbl","Cytosol","2-Octaprenyl3-methyl-6-methoxy- 1,4-benzoquinol","C48H74O3",0]
["2pg","Cytosol","D-Glycerate 2-phosphate","C3H4O7P",-3]
["2shchc","Cytosol","2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate","C11H10O6",-2]
["34hpp","Cytosol","3-(4-Hydroxyphenyl)pyruvate","C9H7O4",-1]
["3c2hmp","Cytosol","3-Carboxy-2-hydroxy-4-methylpentanoate","C7H10O5",-2]
["3c3hmp","Cytosol","3-Carboxy-3-hydroxy-4-methylpentanoate","C7H10O5",-2]
["3c4mop","Cytosol","3-Carboxy-4-methyl-2-oxopentanoate","C7H8O5",-2]
["3dhq","Cytosol","3-Dehydroquinate","C7H9O6",-1]
["3dhsk","Cytosol","3-Dehydroshikimate","C7H7O5",-1]
["3hmrsACP","Cytosol","R-3-hydroxy-myristoyl-ACP","C25H47N2O9PRS",-1]
["3ig3p","Cytosol","C'-(3-Indolyl)-glycerol 3-phosphate","C11H12NO6P",-2]
["3mob","Cytosol","3-Methyl-2-oxobutanoate","C5H7O3",-1]
["3mop","Cytosol","(S)-3-Methyl-2-oxopentanoate","C6H9O3",-1]
["3pg","Cytosol","3-Phospho-D-glycerate","C3H4O7P",-3]
["3php","Cytosol","3-Phosphohydroxypyruvate","C3H2O7P",-3]
["3psme","Cytosol","5-O-(1-Carboxyvinyl)-3-phosphoshikimate","C10H9O10P",-4]
["4abz","Cytosol","4-Aminobenzoate","C7H6NO2",-1]
["4adcho","Cytosol","4-amino-4-deoxychorismate","C10H10NO5",-1]
["4hthr","Cytosol","4-Hydroxy-L-threonine","C4H9NO4",0]
["4mop","Cytosol","4-Methyl-2-oxopentanoate","C6H9O3",-1]
["4pasp","Cytosol","4-Phospho-L-aspartate","C4H6NO7P",-2]
["4per","Cytosol","4-Phospho-D-erythronate","C4H6O8P",-3]
["4ppan","Cytosol","D-4'-Phosphopantothenate","C9H15NO8P",-3]
["4ppcys","Cytosol","N-((R)-4-Phosphopantothenoyl)-L-cysteine","C12H20N2O9PS",-3]
["4r5au","Cytosol","4-(1-D-Ribitylamino)-5-aminouracil","C9H16N4O6",0]
["5aizc","Cytosol","5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate","C9H11N3O9P",-3]
["5aprbu","Cytosol","5-Amino-6-(5'-phosphoribitylamino)uracil","C9H15N4O9P",-2]
["5apru","Cytosol","5-Amino-6-(5'-phosphoribosylamino)uracil","C9H13N4O9P",-2]
["5caiz","Cytosol","5-phosphoribosyl-5-carboxyaminoimidazole","C9H11N3O9P",-3]
["5dpmev","Cytosol","(R)-5-Diphosphomevalonate","C6H10O10P2",-4]
["5ephchc","Cytosol","5-enolpyruvoyl-6-hydroxy-2-succinyl-3-cyclohexene-1-carboxylate","C14H14O9",-3]
["5fthf","Cytosol","5-Formyltetrahydrofolate","C20H21N7O7",-2]
["5mthf","Cytosol","5-Methyltetrahydrofolate","C20H24N7O6",-1]
["5pmev","Cytosol","Mevalonate-5-phosphate","C6H10O7P",-3]
["6hmhpt","Cytosol","6-hydroxymethyl dihydropterin","C7H10N5O2",1]
["6hmhptpp","Cytosol","6-hydroxymethyl-dihydropterin pyrophosphate","C7H9N5O8P2",-2]
["ac","Cytosol","Acetate","C2H3O2",-1]
["ac[e]","Extracellular","Acetate (Extracellular)","C2H3O2",-1]
["acACP","Cytosol","Acetyl-ACP","C13H23N2O8PRS",-1]
["accoa","Cytosol","Acetyl-CoA","C23H34N7O17P3S",-4]
["acg5p","Cytosol","N-Acetyl-L-glutamyl 5-phosphate","C7H9NO8P",-3]
["acg5sa","Cytosol","N-Acetyl-L-glutamate 5-semialdehyde","C7H10NO4",-1]
["acgam1p","Cytosol","N-Acetyl-D-glucosamine 1-phosphate","C8H14NO9P",-2]
["acglu","Cytosol","N-Acetyl-L-glutamate","C7H9NO5",-2]
["acorn","Cytosol","N2-Acetyl-L-ornithine","C7H14N2O3",0]
["ACP","Cytosol","acyl carrier protein","C11H21N2O7PRS",-1]
["acser","Cytosol","O-Acetyl-L-serine","C5H9NO4",0]
["actACP","Cytosol","Acetoacetyl-ACP","C15H25N2O9PRS",-1]
["ade","Cytosol","Adenine","C5H5N5",0]
["adn","Cytosol","Adenosine","C10H13N5O4",0]
["adp","Cytosol","ADP","C10H12N5O10P2",-3]
["agm","Cytosol","Agmatine","C5H16N4",2]
["ahcys","Cytosol","S-Adenosyl-L-homocysteine","C14H20N6O5S",0]
["ahdt","Cytosol","2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate","C9H13N5O13P3",-3]
["aicar","Cytosol","5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide","C9H13N4O8P",-2]
["air","Cytosol","5-amino-1-(5-phospho-D-ribosyl)imidazole","C8H12N3O7P",-2]
["akg","Cytosol","2-Oxoglutarate","C5H4O5",-2]
["akg[e]","Extracellular","2-Oxoglutarate (Extracellular)","C5H4O5",-2]
["ala-D","Cytosol","D-Alanine","C3H7NO2",0]
["ala-L","Cytosol","L-Alanine","C3H7NO2",0]
["ala-L[e]","Extracellular","L-Alanine","C3H7NO2",0]
["alaala","Cytosol","D-Alanyl-D-alanine","C6H12N2O3",0]
["alac-S","Cytosol","(S)-2-Acetolactate","C5H7O4",-1]
["amet","Cytosol","S-Adenosyl-L-methionine","C15H23N6O5S",1]
["amp","Cytosol","AMP","C10H12N5O7P",-2]
["anth","Cytosol","Anthranilate","C7H6NO2",-1]
["apoACP","Cytosol","apoprotein [acyl carrier protein]","RHO",0]
["aps","Cytosol","Adenosine 5'-phosphosulfate","C10H12N5O10PS",-2]
["arg-L","Cytosol","L-Arginine","C6H15N4O2",1]
["arg-L[e]","Extracellular","L-Arginine","C6H15N4O2",1]
["argsuc","Cytosol","N(omega)-(L-Arginino)succinate","C10H17N4O6",-1]
["asn-L","Cytosol","L-Asparagine","C4H8N2O3",0]
["asn-L[e]","Extracellular","L-Asparagine (Extracellular)","C4H8N2O3",0]
["asp-L","Cytosol","L-Aspartate","C4H6NO4",-1]
["asp-L[e]","Extracellular","L-Aspartate","C4H6NO4",-1]
["aspsa","Cytosol","L-Aspartate 4-semialdehyde","C4H7NO3",0]
["atp","Cytosol","ATP","C10H12N5O13P3",-4]
["cbp","Cytosol","Carbamoyl phosphate","CH2NO5P",-2]
["cdp","Cytosol","CDP (cytidine-diphosphate, cytidine-5'-diphosphate)","C9H12N3O11P2",-3]
["cdpdag_Bge","Cytosol","CDPdiacylglycerol (Blattabacterium Blattella germanica) **","C2286H3998N150O750P100",-100]
["chor","Cytosol","Chorismate","C10H8O6",-2]
["cit","Cytosol","Citrate","C6H5O7",-3]
["citr-L","Cytosol","L-Citrulline","C6H13N3O3",0]
["cmp","Cytosol","CMP","C9H12N3O8P",-2]
["co2","Cytosol","CO2","CO2",0]
["co2[e]","Extracellular","CO2 (Extracellular)","CO2",0]
["coa","Cytosol","Coenzyme A","C21H32N7O16P3S",-4]
["csn","Cytosol","Cytosine","C4H5N3O",0]
["ctp","Cytosol","CTP","C9H12N3O14P3",-4]
["cys-L","Cytosol","L-Cysteine","C3H7NO2S",0]
["cys-L[e]","Extracellular","L-Cysteine","C3H7NO2S",0]
["cyst-L","Cytosol","L-Cystathionine","C7H14N2O4S",0]
["cytd","Cytosol","Cytidine","C9H13N3O5",0]
["dad-2","Cytosol","Deoxyadenosine","C10H13N5O3",0]
["dadp","Cytosol","dADP","C10H12N5O9P2",-3]
["damp","Cytosol","dAMP","C10H12N5O6P",-2]
["datp","Cytosol","dATP","C10H12N5O12P3",-4]
["db4p","Cytosol","3,4-dihydroxy-2-butanone 4-phosphate","C4H7O6P",-2]
["dcamp","Cytosol","N6-(1,2-Dicarboxyethyl)-AMP","C14H14N5O11P",-4]
["dcdp","Cytosol","dCDP","C9H12N3O10P2",-3]
["dcmp","Cytosol","dCMP","C9H12N3O7P",-2]
["dctp","Cytosol","dCTP","C9H12N3O13P3",-4]
["dcyt","Cytosol","Deoxycytidine","C9H13N3O4",0,""]
["ddcaACP","Cytosol","Dodecanoyl-ACP (n-C12:0ACP)","C23H43N2O8PRS",-1]
["dgdp","Cytosol","dGDP","C10H12N5O10P2",-3]
["dgmp","Cytosol","dGMP","C10H12N5O7P",-2]
["dgsn","Cytosol","Deoxyguanosine","C10H13N5O4",0]
["dgtp","Cytosol","dGTP","C10H12N5O13P3",-4]
["dhap","Cytosol","Dihydroxyacetone phosphate","C3H5O6P",-2]
["dhf","Cytosol","7,8-Dihydrofolate","C19H20N7O6",-1]
["dhna","Cytosol","1,4-Dihydroxy-2-naphthoate","C11H7O4",-1]
["dhnpt","Cytosol","2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine","C9H14N5O4",1]
["dhor-S","Cytosol","(S)-Dihydroorotate","C5H5N2O4",-1]
["dhor-S[e]","Extracellular","(S)-Dihydroorotate","C5H5N2O4",-1]
["dhpmp","Cytosol","Dihydroneopterin monophosphate","C9H12N5O7P",-2]
["dhpt","Cytosol","Dihydropteroate","C14H13N6O3",-1]
["din","Cytosol","Deoxyinosine","C10H12N4O4",0]
["dmlz","Cytosol","6,7-Dimethyl-8-(1-D-ribityl)lumazine","C13H18N4O6",0]
["dmpp","Cytosol","Dimethylallyl diphosphate","C5H9O7P2",-3]
["dnad","Cytosol","Deamino-NAD+","C21H24N6O15P2",-2]
["dpcoa","Cytosol","Dephospho-CoA","C21H33N7O13P2S",-2]
["dtdp","Cytosol","dTDP","C10H13N2O11P2",-3]
["dtmp","Cytosol","dTMP","C10H13N2O8P",-2]
["dttp","Cytosol","dTTP","C10H13N2O14P3",-4]
["dudp","Cytosol","dUDP","C9H11N2O11P2",-3]
["dump","Cytosol","dUMP","C9H11N2O8P",-2]
["duri","Cytosol","Deoxyuridine","C9H12N2O5",0]
["dutp","Cytosol","dUTP","C9H11N2O14P3",-4]
["dxyl5p","Cytosol","1-deoxy-D-xylulose 5-phosphate","C5H9O7P",-2]
["e4p","Cytosol","D-Erythrose 4-phosphate","C4H7O7P",-2]
["eig3p","Cytosol","D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate","C6H9N2O6P",-2]
["f1p ","Cytosol","D-Fructose 1-phosphate","C6H11O9P",-2]
["f6p","Cytosol","D-Fructose 6-phosphate","C6H11O9P",-2]
["fad","Cytosol","FAD","C27H31N9O15P2",-2]
["fadh2","Cytosol","FADH2","C27H33N9O15P2",-2]
["fdp","Cytosol","D-Fructose 1,6-bisphosphate","C6H10O12P2",-4]
["fe2","Cytosol","Fe2+","Fe",2]
["fe2[e] ","Extracellular","Fe2+ (Extracellular)","Fe",2]
["fgam","Cytosol","N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide","C8H13N2O9P",-2]
["fmn","Cytosol","FMN","C17H19N4O9P",-2]
["for","Cytosol","Formate","CH1O2",-1]
["for[e]","Extracellular","Formate","CH1O2",-1]
["fpram","Cytosol","2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine","C8H15N3O8P",-1]
["fprica","Cytosol","5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","C10H13N4O9P",-2]
["frdp","Cytosol","Farnesyl diphosphate","C15H25O7P2",-3]
["fru","Cytosol","D-Fructose","C6H12O6",0]
["fru[e]","Extracellular","D-Fructose (Extracellular)","C6H12O6",0]
["fum","Cytosol","Fumarate","C4H2O4",-2]
["fum[e]","Extracellular","Fumarate","C4H2O4",-2]
["g3p","Cytosol","Glyceraldehyde 3-phosphate","C3H5O6P",-2]
["gam1p","Cytosol","D-Glucosamine 1-phosphate","C6H13NO8P",-1]
["gam6p","Cytosol","D-Glucosamine 6-phosphate","C6H13NO8P",-1]
["gar","Cytosol","N1-(5-Phospho-D-ribosyl)glycinamide","C7H14N2O8P",-1]
["gcald","Cytosol","Glycolaldehyde","C2H4O2",0]
["gdp","Cytosol","GDP","C10H12N5O11P2",-3]
["gln-L","Cytosol","L-Glutamine","C5H10N2O3",0]
["gln-L[e]","Extracellular","L-Glutamine (Extracellular)","C5H10N2O3",0]
["glu5sa","Cytosol","L-Glutamate 5-semialdehyde","C5H9NO3",0]
["glu-D","Cytosol","D-Glutamate","C5H8NO4",-1]
["glu-L","Cytosol","L-Glutamate","C5H8NO4",-1]
["glu-L[e] ","Extracellular","L-Glutamate","C5H8NO4",-1]
["gly","Cytosol","Glycine","C2H5NO2",0]
["gly[e] ","Extracellular"]
["glyald","Cytosol","D-Glyceraldehyde","C3H6O3",0]
["glyald[e]","Extracellular","D-Glyceraldehyde (Extracellular)","C3H6O3",0]
["glyc","Cytosol","Glycerol","C3H8O3",0]
["glyc[e]","Extracellular","Glycerol (Extracellular)","C3H8O3",0]
["glyc3p","Cytosol","Glycerol 3-phosphate","C3H7O6P",-2]
["glyclt","Cytosol","Glycolate","C2H3O3",-1]
["glyclt[e]","Extracellular","Glycolate (Extracellular)","C2H3O3",-1]
["gmp","Cytosol","GMP","C10H12N5O8P",-2]
["grdp","Cytosol","Geranyl diphosphate","C10H17O7P2",-3]
["gsn","Cytosol","Guanosine","C10H13N5O5",0]
["gtp","Cytosol","GTP","C10H12N5O14P3",-4]
["gua","Cytosol","Guanine","C5H5N5O",0]
["h","Cytosol","H+","H",1]
["h[e]","Extracellular","H+","H",1]
["h2o","Cytosol","H2O","H2O",0]
["h2o[e]","Extracellular","H2O (Extracellular)","H2O",0]
["h2o2","Cytosol","Hydrogen peroxide","H2O2",0]
["h2s","Cytosol","Hydrogen sulfide","H2S",0]
["hco3","Cytosol","Bicarbonate","CHO3",-1]
["hcys-L","Cytosol","L-Homocysteine","C4H9NO2S",0]
["hdeACP","Cytosol","Hexadecenoyl-ACP (n-C16:1ACP)","C27H49N2O8PRS",-1]
["his-L","Cytosol","L-Histidine","C6H9N3O2",0]
["his-L[e]","Extracellular","L-Histidine (Extracellular)","C6H9N3O2",0]
["hisp","Cytosol","L-Histidinol phosphate","C6H11N3O4P",-1]
["histd","Cytosol","L-Histidinol","C6H12N3O",1]
["hmbil","Cytosol","Hydroxymethylbilane","C40H38N4O17",-8]
["hom-L","Cytosol","L-Homoserine","C4H9NO3",0]
["hxan","Cytosol","Hypoxanthine","C5H4N4O",0]
["ichor","Cytosol","Isochorismate","C10H8O6",-2]
["icit","Cytosol","Isocitrate","C6H5O7",-3]
["idp","Cytosol","IDP","C10H11N4O11P2",-3]
["ile-L","Cytosol","L-Isoleucine","C6H13NO2",0]
["ile-L[e]","Extracellular","L-Isoleucine","C6H13NO2",0]
["imacp","Cytosol","3-(Imidazol-4-yl)-2-oxopropyl phosphate","C6H7N2O5P",-2]
["imp","Cytosol","IMP","C10H11N4O8P",-2]
["indole","Cytosol","Indole","C8H7N",0]
["ins","Cytosol","Inosine","C10H12N4O5",0]
["ipdp","Cytosol","Isopentenyl diphosphate","C5H9O7P2",-3]
["itp","Cytosol","ITP","C10H11N4O14P3",-4]
["k","Cytosol","K+","K",1]
["k[e]","Extracellular","K+ (Extracellular)","K",1]
["leu-L","Cytosol","L-Leucine","C6H13NO2",0]
["leu-L[e]","Extracellular","L-Leucine (Extracellular)","C6H13NO2",0]
["lys-L","Cytosol","L-Lysine","C6H15N2O2",1]
["lys-L[e]","Extracellular","L-Lysine (Extracellular)","C6H15N2O2",1]
["mal-L","Cytosol","L-Malate","C4H4O5",-2]
["mal-L[e]","Extracellular","L-Malate (Extracellular)","C4H4O5",-2]
["malACP","Cytosol","Malonyl-[acyl-carrier protein]","C14H22N2O10PRS",-2]
["malcoa","Cytosol","Malonyl-CoA","C24H33N7O19P3S",-5]
["met-L","Cytosol","L-Methionine","C5H11NO2S",0]
["met-L[e]","Extracellular","L-Methionine (Extracellular)","C5H11NO2S",0]
["methf","Cytosol","5,10-Methenyltetrahydrofolate","C20H20N7O6",-1]
["mev-R","Cytosol","(R)-mevalonate","C6H11O4",-1]
["mlthf","Cytosol","5,10-Methylenetetrahydrofolate","C20H22N7O6",-1]
["mql8","Cytosol","Menaquinol 8","C51H74O2",0]
["mqn8","Cytosol","Menaquinone 8","C51H72O2",0]
["myrsACP","Cytosol","Myristoyl-ACP (n-C14:0ACP)","C25H47N2O8PRS",-1]
["na1","Cytosol","Sodium","Na",1]
["na1[e]","Extracellular","Sodium (Extracellular)","Na",1]
["nac","Cytosol","Nicotinate","C6H4NO2",-1]
["nac[e]","Extracellular","Nicotinate","C6H4NO2",-1]
["nad","Cytosol","Nicotinamide adenine dinucleotide","C21H26N7O14P2",-1]
["nadh","Cytosol","Nicotinamide adenine dinucleotide - reduced","C21H27N7O14P2",-2]
["nadp","Cytosol","Nicotinamide adenine dinucleotide phosphate","C21H25N7O17P3",-3]
["nadph","Cytosol","Nicotinamide adenine dinucleotide phosphate - reduced","C21H26N7O17P3",-4]
["nh4","Cytosol","ammonium","H4N",1]
["nh4[e]","Extracellular","ammonium (Extracellular)","H4N",1]
["nicrnt","Cytosol","Nicotinate D-ribonucleotide","C11H12NO9P",-2]
["nmn","Cytosol","NMN","C11H14N2O8P",-1]
["o2","Cytosol","O2","O2",0]
["o2[e]","Extracellular","O2 (Extracellular)","O2",0]
["o2s","Cytosol","Superoxide anion","O2",-1]
["oaa","Cytosol","Oxaloacetate","C4H2O5",-2]
["octdp","Cytosol","all-trans-Octaprenyl diphosphate","C40H65O7P2",-3]
["octeACP","Cytosol","Octadecenoyl-ACP (n-C18:1ACP)","C29H53N2O8PRS",-1]
["ohpb","Cytosol","2-Oxo-3-hydroxy-4-phosphobutanoate","C4H4O8P",-3]
["orn","Cytosol","Ornithine","C5H13N2O2",1]
["orot","Cytosol","Orotate","C5H3N2O4",-1]
["orot5p","Cytosol","Orotidine 5'-phosphate","C10H10N2O11P",-3]
["pa_Bge","Cytosol","phosphatidate (Blattabacterium Blattella germanica) **","C1836H3398O400P50",-100]
["palmACP","Cytosol","Palmitoyl-ACP (n-C16:0ACP)","C27H51N2O8PRS",-1]
["pan4p","Cytosol","Pantetheine 4'-phosphate","C11H21N2O7PS",-2]
["pap","Cytosol","Adenosine 3',5'-bisphosphate","C10H11N5O10P2",-4]
["paps","Cytosol","3'-Phosphoadenylyl sulfate","C10H11N5O13P2S",-4]
["pdx5p","Cytosol","Pyridoxine 5'-phosphate","C8H10NO6P",-2]
["pe_Bge","Cytosol","Phosphatidylethanolamine (Blattabacterium Blattella germanica) **","C1936H3748N50O400P50",0]
["pep","Cytosol","Phosphoenolpyruvate","C3H2O6P",-3]
["peptido_Bge","Cytosol","Peptidoglycan subunit of Blattabacterium Blattella germanica","C40H62N8O21",-2]
["phe-L","Cytosol","L-Phenylalanine","C9H11NO2",0]
["phe-L[e]","Extracellular","L-Phenylalanine (Extracellular)","C9H11NO2",0]
["phom","Cytosol","O-Phospho-L-homoserine","C4H8NO6P",-2]
["phpyr","Cytosol","Phenylpyruvate","C9H7O3",-1]
["phthr","Cytosol","O-Phospho-4-hydroxy-L-threonine","C4H8NO7P",-2]
["pi","Cytosol","Phosphate","HO4P",-2]
["pi[e]","Extracellular","Phosphate (Extracellular)","HO4P",-2]
["pnto-R","Cytosol","(R)-Pantothenate","C9H16NO5",-1]
["pnto-R[e]","Extracellular","(R)-Pantothenate (Extracellular)","C9H16NO5",-1]
["ppbng","Cytosol","Porphobilinogen","C10H13N2O4",-1]
["ppbng[e]","Extracellular","Porphobilinogen","C10H13N2O4",-1]
["pphn","Cytosol","Prephenate","C10H8O6",-2]
["ppi","Cytosol","Diphosphate","HO7P2",-3]
["pram","Cytosol","5-Phospho-beta-D-ribosylamine","C5H11NO7P",-1]
["pran","Cytosol","N-(5-Phospho-D-ribosyl)anthranilate","C12H13NO9P",-3]
["prbamp","Cytosol","1-(5-Phosphoribosyl)-AMP","C15H19N5O14P2",-4]
["prbatp","Cytosol","1-(5-Phosphoribosyl)-ATP","C15H19N5O20P4",-6]
["prfp","Cytosol","1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide","C15H21N5O15P2",-4]
["prlp","Cytosol","5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide","C15H21N5O15P2",-4]
["pro-L","Cytosol","L-Proline","C5H9NO2",0]
["pro-L[e] ","Extracellular","L-Proline (Extracellular)","C5H9NO2",0]
["prpp","Cytosol","5-Phospho-alpha-D-ribose 1-diphosphate","C5H8O14P3",-5]
["ps_Bge","Cytosol","phosphatidylserine (Blattabacterium Blattella germanica) **","C1986H3698N50O500P50",-50]
["pser-L","Cytosol","O-Phospho-L-serine","C3H6NO6P",-2]
["ptrc","Cytosol","Putrescine","C4H14N2",2]
["pyam5p","Cytosol","Pyridoxamine 5'-phosphate","C8H12N2O5P",-1]
["pydx5p","Cytosol","Pyridoxal 5'-phosphate","C8H8NO6P",-2]
["pydx","Cytosol","Pyridoxal","C8H9NO3",0]
["pyr","Cytosol","Pyruvate","C3H3O3",-1]
["pyr[e]","Extracellular","Pyruvate (Extracellular)","C3H3O3",-1]
["r1p","Cytosol","alpha-D-Ribose 1-phosphate","C5H9O8P",-2]
["r5p","Cytosol","alpha-D-Ribose 5-phosphate","C5H9O8P",-2]
["ribflv","Cytosol","Riboflavin","C17H20N4O6",0]
["ru5p-D","Cytosol","D-Ribulose 5-phosphate","C5H9O8P",-2]
["s7p","Cytosol","Sedoheptulose 7-phosphate","C7H13O10P",-2]
["sbzcoa","Cytosol","O-Succinylbenzoyl-CoA","C32H39N7O20P3S",-5]
["ser-L","Cytosol","L-Serine","C3H7NO3",0]
["ser-L[e]","Extracellular","L-Serine (Extracellular)","C3H7NO3",0]
["skm","Cytosol","Shikimate","C7H9O5",-1]
["skm5p","Cytosol","Shikimate 5-phosphate","C7H8O8P",-3]
["sl26da","Cytosol","N-Succinyl-LL-2,6-diaminoheptanedioate","C11H16N2O7",-2]
["sl2a6o","Cytosol","N-Succinyl-2-L-amino-6-oxoheptanedioate","C11H12NO8",-3]
["so3","Cytosol","Sulfite","O3S",-2]
["so4","Cytosol","Sulfate","O4S",-2]
["so4[e] ","Extracellular","Sulfate","O4S",-2]
["ssaltpp","Cytosol","Succinate semialdehyde-thiamin diphosphate anion_","C16H21N4O10P2S",-3]
["sucbz","Cytosol","o-Succinylbenzoate","C11H8O5",-2]
["succ","Cytosol","Succinate","C4H4O4",-2]
["succ[e]","Extracellular","Succinate (Extracellular)","C4H4O4",-2]
["succoa","Cytosol","Succinyl-CoA","C25H35N7O19P3S",-5]
["suchms","Cytosol","O-Succinyl-L-homoserine","C8H12NO6",-1]
["tdeACP","Cytosol","Tetradecenoyl-ACP (n-C14:1ACP)","C25H45N2O8PRS",-1]
["thdp","Cytosol","2,3,4,5-Tetrahydrodipicolinate","C7H7NO4",-2]
["thf","Cytosol","5,6,7,8-Tetrahydrofolate","C19H22N7O6",-1]
["thm","Cytosol","Thiamin","C12H17N4OS",1]
["thm[e]","Extracellular","Thiamin (Extracellular)","C12H17N4OS",1]
["thmpp","Cytosol","Thiamine diphosphate","C12H16N4O7P2S",-2]
["thr-L","Cytosol","L-Threonine","C4H9NO3",0]
["thr-L[e]","Extracellular","L-Threonine (Extracellular)","C4H9NO3",0]
["thym","Cytosol","Thymine","C5H6N2O2",0]
["thymd","Cytosol","Thymidine","C10H14N2O5",0]
["trdox","Cytosol","Oxidized thioredoxin","X",0]
["trdrd","Cytosol","Reduced thioredoxin","XH2",0]
["trp-L","Cytosol","L-Tryptophan","C11H12N2O2",0]
["trp-L[e]","Extracellular","L-Tryptophan (Extracellular)","C11H12N2O2",0]
["tyr-L","Cytosol","L-Tyrosine","C9H11NO3",0]
["tyr-L[e]","Extracellular","L-Tyrosine (Extracellular)","C9H11NO3",0]
["u3aga","Cytosol","UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine","C31H51N3O19P2",-2]
["u3hga","Cytosol","UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine","C29H50N3O18P2",-1]
["uaagmda","Cytosol","Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-ala-D-glu-meso-2,6-diaminopimeloyl-D-ala-D-ala","C95H152N8O28P2",-4]
["uaccg","Cytosol","UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine","C20H26N3O19P2",-3]
["uacgam","Cytosol","UDP-N-acetyl-D-glucosamine","C17H25N3O17P2",-2]
["uagmda","Cytosol","Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine","C87H139N7O23P2",-4]
["uama","Cytosol","UDP-N-acetylmuramoyl-L-alanine","C23H33N4O20P2",-3]
["uamag","Cytosol","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate","C28H39N5O23P2",-4]
["uamr","Cytosol","UDP-N-acetylmuramate","C20H28N3O19P2",-3]
["udcpdp","Cytosol","Undecaprenyl diphosphate","C55H89O7P2",-3]
["udcpp","Cytosol","Undecaprenyl phosphate","C55H89O4P",-2]
["udp","Cytosol","UDP","C9H11N2O12P2",-3]
["ugmd","Cytosol","UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate","C35H51N7O26P2",-4]
["ugmda","Cytosol","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine","C41H61N9O28P2",-4]
["ump","Cytosol","UMP","C9H11N2O9P",-2]
["uppg3","Cytosol","Uroporphyrinogen III","C40H36N4O16",-8]
["ura","Cytosol","Uracil","C4H4N2O2",0]
["urea","Cytosol","Urea","CH4N2O",0]
["urea[e]","Extracellular","Urea","CH4N2O",0]
["uri","Cytosol","Uridine","C9H12N2O6",0]
["utp","Cytosol","UTP","C9H11N2O15P3",-4]
["val-L","Cytosol","L-Valine","C5H11NO2",0]
["val-L[e]","Extracellular","L-Valine (Extracellular)","C5H11NO2",0]
["xan","Cytosol","Xanthine","C5H4N4O2",0]
["xmp","Cytosol","Xanthosine 5'-phosphate","C10H11N4O9P",-2]
["xtsn","Cytosol","Xanthosine","C10H12N4O6",0]
["xu5p-D","Cytosol","D-Xylulose 5-phosphate","C5H9O8P",-2]

{"sheet":"Dead End Metab","index":4,"n_rows":14,"n_cols":5,"rows_kept":14,"merged":[[0,0,0,4]],"flags":["formulas_cached_only"]}
["Dead End Metabolites"]
["Abbr","Name","Location","RxnParticipation","No. Rxns "]
["1pyr5c","1-Pyrroline-5-carboxylate","Cytosol","Product",1]
["2ombzl","2-Octaprenyl-6-methoxy-1,4-benzoquinol","Cytosol","Substrate",1]
["2ommbl","2-Octaprenyl3-methyl-6-methoxy- 1,4-benzoquinol","Cytosol","Product",1]
["4hthr","4-Hydroxy-L-threonine","Cytosol","Product",1]
["apoACP","apoprotein [acyl carrier protein","Cytosol","Substrate",1]
["fe2","Fe2+","Cytosol","Product",1]
["k","K+","Cytosol","Product",1]
["mev-R","(R)-mevalonate","Cytosol","Substrate",1]
["o2s","Superoxide anion","Cytosol","Substrate",1]
["thym","Thymine","Cytosol","Product",1]
["u3hga","UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine","Cytosol","Product",1]
["uppg3","Uroporphyrinogen III","Cytosol","Product",1]