{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Sheet0"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet0","index":0,"n_rows":158,"n_cols":4,"rows_kept":158,"flags":["formulas_cached_only"]}
["© 2000-2011 Ingenuity Systems, Inc. All rights reserved."]
["Ingenuity Canonical Pathways"," -log(p-value)","Ratio","Molecules"]
["Role of JAK1 and JAK3 in γc Cytokine Signaling","3.61E00","6.25E-02","SOCS1,IRS1,IL2RA,IRS2"]
["Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis","3.23E00","2.26E-02","SOCS1,PDGFA,CEBPD,MAP2K3,DKK1,FZD2,TNFRSF11B"]
["Role of JAK2 in Hormone-like Cytokine Signaling","3.22E00","8.57E-02","SOCS1,IRS1,IRS2"]
["IL-9 Signaling","3.19E00","7.89E-02","IRS1,IRS2,BCL3"]
["Nicotinate and Nicotinamide Metabolism","2.84E00","4.12E-02","PIM1,MAP3K8,MAP2K3,BST1"]
["Type II Diabetes Mellitus Signaling","2.6E00","3.17E-02","SOCS1,IRS1,IRS2,TNFRSF11B"]
["Role of IL-17A in Arthritis","2.6E00","5E-02","CCL7,CCL20,MAP2K3"]
["Human Embryonic Stem Cell Pluripotency","2.38E00","2.76E-02","PDGFA,BMP2,SPHK1,FZD2"]
["Cardiac β-adrenergic Signaling","2.36E00","2.9E-02","AKAP12,AKAP2/PALM2-AKAP2,PPP1R12A,AKAP7"]
["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis","2.33E00","2.2E-02","BMP2,MAP2K3,DKK1,FZD2,TNFRSF11B"]
["Chemokine Signaling","2.32E00","4.41E-02","CCL7,PPP1R12A,CCL11"]
["Acute Myeloid Leukemia Signaling","2.17E00","3.7E-02","CCNA1,PIM1,MAP2K3"]
["NF-κB Signaling","2.04E00","2.35E-02","BMP2,TNFAIP3,MAP3K8,TNFRSF11B"]
["Factors Promoting Cardiogenesis in Vertebrates","2.02E00","3.3E-02","BMP2,DKK1,FZD2"]
["IL-6 Signaling","1.93E00","3.06E-02","SOCS1,MAP2K3,TNFRSF11B"]
["ILK Signaling","1.91E00","2.2E-02","IRS1,BMP2,PPP1R12A,IRS2"]
["IGF-1 Signaling","1.89E00","2.94E-02","SOCS1,IRS1,IRS2"]
["IL-17A Signaling in Fibroblasts","1.88E00","5.13E-02","CCL7,CEBPD"]
["Type I Diabetes Mellitus Signaling","1.78E00","2.63E-02","SOCS1,MAP2K3,TNFRSF11B"]
["Protein Kinase A Signaling","1.76E00","1.63E-02","AKAP12,AKAP2/PALM2-AKAP2,PPP1R12A,AKAP7,CDC27"]
["cAMP-mediated signaling","1.66E00","1.87E-02","AKAP12,AKAP2/PALM2-AKAP2,GLP1R,AKAP7"]
["Insulin Receptor Signaling","1.62E00","2.38E-02","IRS1,PPP1R12A,IRS2"]
["CD27 Signaling in Lymphocytes","1.57E00","3.64E-02","MAP3K8,MAP2K3"]
["AMPK Signaling","1.55E00","2.13E-02","IRS1,IRS2,MAP2K3"]
["IL-2 Signaling","1.54E00","3.57E-02","SOCS1,IL2RA"]
["Inositol Phosphate Metabolism","1.52E00","2.19E-02","PIM1,MAP3K8,MAP2K3"]
["Hepatic Fibrosis / Hepatic Stellate Cell Activation","1.5E00","2.14E-02","PDGFA,HGF,TNFRSF11B"]
["CD40 Signaling","1.41E00","2.94E-02","TNFAIP3,MAP2K3"]
["GM-CSF Signaling","1.41E00","3.03E-02","PIM1,HCK"]
["IL-17A Signaling in Airway Cells","1.4E00","2.9E-02","CCL20,CCL11"]
["Production of Nitric Oxide and Reactive Oxygen Species in Macrophages","1.37E00","1.85E-02","PPP1R12A,MAP3K8,TNFRSF11B"]
["Clathrin-mediated Endocytosis Signaling","1.35E00","1.81E-02","SH3BP4,PDGFA,DAB2"]
["T Helper Cell Differentiation","1.35E00","2.9E-02","IL2RA,TNFRSF11B"]
["IL-4 Signaling","1.35E00","2.9E-02","SOCS1,IRS1"]
["Growth Hormone Signaling","1.34E00","2.82E-02","SOCS1,IRS1"]
["Macropinocytosis Signaling","1.34E00","2.63E-02","PDGFA,HGF"]
["Basal Cell Carcinoma Signaling","1.32E00","2.78E-02","BMP2,FZD2"]
["PDGF Signaling","1.3E00","2.74E-02","PDGFA,SPHK1"]
["IL-17 Signaling","1.29E00","2.7E-02","MAP2K3,CCL11"]
["Acute Phase Response Signaling","1.29E00","1.74E-02","SOCS1,MAP2K3,TNFRSF11B"]
["Prolactin Signaling","1.28E00","2.6E-02","SOCS1,IRS1"]
["LXR/RXR Activation","1.25E00","2.41E-02","CCL7,TNFRSF11B"]
["Ceramide Signaling","1.23E00","2.44E-02","SPHK1,TNFRSF11B"]
["Role of IL-17A in Psoriasis","1.2E00","7.69E-02","CCL20"]
["TGF-β Signaling","1.18E00","2.25E-02","BMP2,MAP2K3"]
["FGF Signaling","1.18E00","2.33E-02","HGF,MAP2K3"]
["PPAR Signaling","1.12E00","1.98E-02","PDGFA,TNFRSF11B"]
["Atherosclerosis Signaling","1.11E00","1.96E-02","PDGFA,CCL11"]
["HMGB1 Signaling","1.1E00","2.06E-02","MAP2K3,TNFRSF11B"]
["SAPK/JNK Signaling","1.1E00","2E-02","IRS1,DUSP10"]
["Cardiomyocyte Differentiation via BMP Receptors","1.06E00","5.26E-02","BMP2"]
["Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F","1.06E00","5.56E-02","CSF3"]
["Molecular Mechanisms of Cancer","1.06E00","1.11E-02","IRS1,BMP2,MAP2K3,FZD2"]
["HGF Signaling","1.05E00","1.96E-02","HGF,MAP3K8"]
["DNA Methylation and Transcriptional Repression Signaling","1.02E00","4.35E-02","SAP30"]
["Pantothenate and CoA Biosynthesis","1.02E00","5E-02","DPYSL2"]
["Cardiac Hypertrophy Signaling","1.01E00","1.32E-02","IRS1,MAP3K8,MAP2K3"]
["Role of Tissue Factor in Cancer","1E00","1.85E-02","HCK,HBEGF"]
["p38 MAPK Signaling","1E00","1.89E-02","DUSP10,MAP2K3"]
["Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency","9.83E-01","1.77E-02","BMP2,FZD2"]
["Sphingosine-1-phosphate Signaling","9.83E-01","1.72E-02","PDGFA,SPHK1"]
["Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F","9.79E-01","4.55E-02","CSF3"]
["CCR3 Signaling in Eosinophils","9.57E-01","1.68E-02","PPP1R12A,CCL11"]
["Role of JAK1, JAK2 and TYK2 in Interferon Signaling","9.43E-01","3.85E-02","SOCS1"]
["IL-17A Signaling in Gastric Cells","9.27E-01","4E-02","CCL20"]
["Role of JAK family kinases in IL-6-type Cytokine Signaling","9.27E-01","3.85E-02","SOCS1"]
["Antiproliferative Role of TOB in T Cell Signaling","9.11E-01","3.85E-02","CCNA1"]
["GNRH Signaling","8.9E-01","1.52E-02","MAP3K8,MAP2K3"]
["TNFR2 Signaling","8.81E-01","3.12E-02","TNFAIP3"]
["Axonal Guidance Signaling","8.8E-01","9.48E-03","DPYSL2,PDGFA,BMP2,FZD2"]
["PI3K Signaling in B Lymphocytes","8.79E-01","1.53E-02","IRS1,IRS2"]
["Circadian Rhythm Signaling","8.4E-01","3.03E-02","BHLHE40"]
["Hepatic Cholestasis","8.26E-01","1.41E-02","TJP2,TNFRSF11B"]
["Interferon Signaling","8.03E-01","2.94E-02","SOCS1"]
["B Cell Receptor Signaling","7.97E-01","1.35E-02","MAP3K8,MAP2K3"]
["Glioblastoma Multiforme Signaling","7.82E-01","1.27E-02","PDGFA,FZD2"]
["Notch Signaling","7.69E-01","2.44E-02","JAG1"]
["Tight Junction Signaling","7.51E-01","1.27E-02","TJP2,TNFRSF11B"]
["Retinol Metabolism","7.48E-01","2.56E-02","BMP2"]
["Role of PKR in Interferon Induction and Antiviral Response","7.38E-01","2.27E-02","MAP2K3"]
["Role of IL-17F in Allergic Inflammatory Airway Diseases","7.38E-01","2.38E-02","CCL7"]
["Germ Cell-Sertoli Cell Junction Signaling","7.33E-01","1.26E-02","MAP3K8,MAP2K3"]
["PPARα/RXRα Activation","7.25E-01","1.2E-02","IRS1,MAP2K3"]
["Wnt/β-catenin Signaling","6.89E-01","1.18E-02","DKK1,FZD2"]
["β-alanine Metabolism","6.84E-01","2.17E-02","DPYSL2"]
["TNFR1 Signaling","6.76E-01","1.96E-02","TNFAIP3"]
["Toll-like Receptor Signaling","6.59E-01","1.96E-02","MAP2K3"]
["NRF2-mediated Oxidative Stress Response","6.48E-01","1.06E-02","MAP2K3,MAFF"]
["TREM1 Signaling","6.44E-01","1.89E-02","CCL7"]
["Role of Cytokines in Mediating Communication between Immune Cells","6.37E-01","1.92E-02","CSF3"]
["Semaphorin Signaling in Neurons","6.37E-01","1.92E-02","DPYSL2"]
["Thrombopoietin Signaling","6.16E-01","1.69E-02","IRS2"]
["Mitotic Roles of Polo-Like Kinase","5.96E-01","1.67E-02","CDC27"]
["Induction of Apoptosis by HIV1","5.89E-01","1.59E-02","TNFRSF11B"]
["ERK5 Signaling","5.77E-01","1.61E-02","MAP3K8"]
["JAK/Stat Signaling","5.77E-01","1.56E-02","SOCS1"]
["Role of MAPK Signaling in the Pathogenesis of Influenza","5.65E-01","1.59E-02","MAP2K3"]
["Actin Cytoskeleton Signaling","5.6E-01","8.89E-03","PDGFA,PPP1R12A"]
["Erythropoietin Signaling","5.42E-01","1.35E-02","SOCS1"]
["Melatonin Signaling","5.42E-01","1.47E-02","MAP2K3"]
["IL-10 Signaling","5.37E-01","1.39E-02","MAP2K3"]
["Neurotrophin/TRK Signaling","5.37E-01","1.41E-02","MAP2K3"]
["Renal Cell Carcinoma Signaling","5.31E-01","1.41E-02","HGF"]
["BMP signaling pathway","5.16E-01","1.32E-02","BMP2"]
["LPS-stimulated MAPK Signaling","5.11E-01","1.27E-02","MAP2K3"]
["Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza","5.06E-01","1.3E-02","FZD2"]
["Dopamine Receptor Signaling","4.97E-01","1.3E-02","PPP1R12A"]
["Cyclins and Cell Cycle Regulation","4.92E-01","1.15E-02","CCNA1"]
["VDR/RXR Activation","4.87E-01","1.27E-02","PDGFA"]
["Reelin Signaling in Neurons","4.83E-01","1.22E-02","HCK"]
["Colorectal Cancer Metastasis Signaling","4.83E-01","8.2E-03","MMP23A,FZD2"]
["Phospholipid Degradation","4.78E-01","1.25E-02","CLC"]
["Sphingolipid Metabolism","4.7E-01","1.22E-02","SPHK1"]
["Regulation of Actin-based Motility by Rho","4.7E-01","1.16E-02","PPP1R12A"]
["TR/RXR Activation","4.57E-01","1.12E-02","BCL3"]
["Neuregulin Signaling","4.53E-01","1.05E-02","HBEGF"]
["RANK Signaling in Osteoclasts","4.53E-01","1.09E-02","MAP3K8"]
["CDK5 Signaling","4.49E-01","1.12E-02","PPP1R12A"]
["Bladder Cancer Signaling","4.49E-01","1.11E-02","MMP23A"]
["PAK Signaling","4.45E-01","9.62E-03","PDGFA"]
["G Beta Gamma Signaling","4.41E-01","1.01E-02","HBEGF"]
["Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes","4.3E-01","1.06E-02","HCK"]
["IL-1 Signaling","4.3E-01","9.9E-03","MAP2K3"]
["Xenobiotic Metabolism Signaling","4.28E-01","7.55E-03","MAP3K8,MAP2K3"]
["Glioma Signaling","4.22E-01","9.43E-03","PDGFA"]
["HIF1α Signaling","3.98E-01","9.71E-03","MMP23A"]
["Cholecystokinin/Gastrin-mediated Signaling","3.98E-01","9.9E-03","MAP2K3"]
["Synaptic Long Term Potentiation","3.92E-01","9.62E-03","PPP1R12A"]
["Fc Epsilon RI Signaling","3.92E-01","9.52E-03","MAP2K3"]
["iCOS-iCOSL Signaling in T Helper Cells","3.92E-01","8.93E-03","IL2RA"]
["Pancreatic Adenocarcinoma Signaling","3.85E-01","8.77E-03","HBEGF"]
["IL-12 Signaling and Production in Macrophages","3.82E-01","8.85E-03","MAP3K8"]
["RhoA Signaling","3.73E-01","9.17E-03","PPP1R12A"]
["PKCθ Signaling in T Lymphocytes","3.61E-01","7.87E-03","MAP3K8"]
["PI3K/AKT Signaling","3.56E-01","7.75E-03","MAP3K8"]
["p70S6K Signaling","3.47E-01","8.2E-03","IRS1"]
["Glycerophospholipid Metabolism","3.45E-01","8.4E-03","CLC"]
["Cellular Effects of Sildenafil (Viagra)","3.27E-01","7.81E-03","PPP1R12A"]
["G-Protein Coupled Receptor Signaling","3.2E-01","5.77E-03","GLP1R,MAP3K8,FZD2"]
["Cdc42 Signaling","3.19E-01","6.99E-03","PPP1R12A"]
["Ovarian Cancer Signaling","3.15E-01","7.25E-03","FZD2"]
["Aryl Hydrocarbon Receptor Signaling","3.1E-01","7.09E-03","CCNA1"]
["Pyrimidine Metabolism","3.03E-01","7.35E-03","DPYSL2"]
["Regulation of eIF4 and p70S6K Signaling","2.88E-01","6.29E-03","IRS1"]
["Dendritic Cell Maturation","2.7E-01","5.81E-03","TNFRSF11B"]
["RAR Activation","2.42E-01","5.75E-03","BMP2"]
["IL-8 Signaling","2.37E-01","5.62E-03","HBEGF"]
["Ephrin Receptor Signaling","2.37E-01","5.15E-03","PDGFA"]
["Role of NFAT in Cardiac Hypertrophy","2.28E-01","5.32E-03","MAP2K3"]
["mTOR Signaling","2.26E-01","5.41E-03","IRS1"]
["ERK/MAPK Signaling","2.17E-01","5.05E-03","PPP1R12A"]
["Leukocyte Extravasation Signaling","2.14E-01","5.29E-03","MMP23A"]
["Thrombin Signaling","2.12E-01","5.1E-03","PPP1R12A"]
["LPS/IL-1 Mediated Inhibition of RXR Function","2.09E-01","4.95E-03","TNFRSF11B"]
["Breast Cancer Regulation by Stathmin1","2.05E-01","5.03E-03","PPP1R12A"]
["Integrin Signaling","2.03E-01","4.88E-03","PPP1R12A"]