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["Additional Table 7 The set of 196 downregulated genes and 6 upregulated genes in U373MG cells shared among the compounds 1a, 2a, and 3 treatments"]
["Entrez Gene ID","Gene Symbol","Gene Name"]
["196 downregulated genes "]
[19,"ABCA1 ","ATP-binding cassette, sub-family A (ABC1), member 1"]
[31,"ACACA ","acetyl-Coenzyme A carboxylase alpha"]
[132,"ADK ","adenosine kinase"]
[323,"APBB2 ","amyloid beta (A4) precursor protein-binding, family B, member 2"]
[594,"BCKDHB ","branched chain keto acid dehydrogenase E1, beta polypeptide"]
[636,"BICD1 ","bicaudal D homolog 1 (Drosophila)"]
[658,"BMPR1B ","bone morphogenetic protein receptor, type IB"]
[659,"BMPR2 ","bone morphogenetic protein receptor, type II (serine/threonine kinase)"]
[817,"CAMK2D ","calcium/calmodulin-dependent protein kinase II delta"]
[987,"LRBA ","LPS-responsive vesicle trafficking, beach and anchor containing"]
[1009,"CDH11 ","cadherin 11, type 2, OB-cadherin (osteoblast)"]
[1602,"DACH1 ","dachshund homolog 1 (Drosophila)"]
[1730,"DIAPH2 ","diaphanous homolog 2 (Drosophila)"]
[1739,"DLG1 ","discs, large homolog 1 (Drosophila)"]
[1793,"DOCK1 ","dedicator of cytokinesis 1"]
[1806,"DPYD ","dihydropyrimidine dehydrogenase"]
[2042,"EPHA3 ","EPH receptor A3"]
[2070,"EYA4 ","eyes absent homolog 4 (Drosophila)"]
[2120,"ETV6 ","ets variant 6"]
[2200,"FBN1 ","fibrillin 1"]
[2241,"FER ","fer (fps/fes related) tyrosine kinase"]
[2530,"FUT8 ","fucosyltransferase 8 (alpha (1,6) fucosyltransferase)"]
[2534,"FYN ","FYN oncogene related to SRC, FGR, YES"]
[2632,"GBE1 ","glucan (1,4-alpha-), branching enzyme 1"]
[2737,"GLI3 ","GLI family zinc finger 3"]
[2762,"GMDS ","GDP-mannose 4,6-dehydratase"]
[2776,"GNAQ ","guanine nucleotide binding protein (G protein), q polypeptide"]
[2887,"GRB10 ","growth factor receptor-bound protein 10"]
[2932,"GSK3B ","glycogen synthase kinase 3 beta"]
[3632,"INPP5A ","inositol polyphosphate-5-phosphatase, 40kDa"]
[3708,"ITPR1 ","inositol 1,4,5-triphosphate receptor, type 1"]
[3709,"ITPR2 ","inositol 1,4,5-triphosphate receptor, type 2"]
[3720,"JARID2 ","jumonji, AT rich interactive domain 2"]
[4026,"LPP ","LIM domain containing preferred translocation partner in lipoma"]
[4064,"CD180 ","CD180 molecule"]
[4133,"MAP2 ","microtubule-associated protein 2"]
[4249,"MGAT5 ","mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase"]
[4300,"MLLT3 ","myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3"]
[4643,"MYO1E ","myosin IE"]
[4649,"MYO9A ","myosin IXA"]
[4651,"MYO10 ","myosin X"]
[4693,"NDP ","Norrie disease (pseudoglioma)"]
[4897,"NRCAM ","neuronal cell adhesion molecule"]
[5087,"PBX1 ","pre-B-cell leukemia homeobox 1"]
[5137,"PDE1C ","phosphodiesterase 1C, calmodulin-dependent 70kDa"]
[5218,"CDK14 ","cyclin-dependent kinase 14"]
[5291,"PIK3CB ","phosphoinositide-3-kinase, catalytic, beta polypeptide"]
[5578,"PRKCA ","protein kinase C, alpha"]
[5587,"PRKD1 ","protein kinase D1"]
[5747,"PTK2 ","PTK2 protein tyrosine kinase 2"]
[5793,"PTPRG ","protein tyrosine phosphatase, receptor type, G"]
[5795,"PTPRJ ","protein tyrosine phosphatase, receptor type, J"]
[5796,"PTPRK ","protein tyrosine phosphatase, receptor type, K"]
[5803,"PTPRZ1 ","protein tyrosine phosphatase, receptor-type, Z polypeptide 1"]
[5915,"RARB ","retinoic acid receptor, beta"]
[6091,"ROBO1 ","roundabout, axon guidance receptor, homolog 1 (Drosophila)"]
[6310,"ATXN1 ","ataxin 1"]
[6482,"ST3GAL1 ","ST3 beta-galactoside alpha-2,3-sialyltransferase 1"]
[6788,"STK3 ","serine/threonine kinase 3 (STE20 homolog, yeast)"]
[6840,"SVIL ","supervillin"]
[6869,"TACR1 ","tachykinin receptor 1"]
[6934,"TCF7L2 ","transcription factor 7-like 2 (T-cell specific, HMG-box)"]
[7039,"TGFA ","transforming growth factor, alpha"]
[7068,"THRB ","thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)"]
[7402,"UTRN ","utrophin"]
[7405,"UVRAG ","UV radiation resistance associated gene"]
[7518,"XRCC4 ","X-ray repair complementing defective repair in Chinese hamster cells 4"]
[7813,"EVI5 ","ecotropic viral integration site 5"]
[8464,"SUPT3H ","suppressor of Ty 3 homolog (S. cerevisiae)"]
[8476,"CDC42BPA ","CDC42 binding protein kinase alpha (DMPK-like)"]
[8573,"CASK ","calcium/calmodulin-dependent serine protein kinase (MAGUK family)"]
[8633,"UNC5C ","unc-5 homolog C (C. elegans)"]
[8648,"NCOA1 ","nuclear receptor coactivator 1"]
[8672,"EIF4G3 ","eukaryotic translation initiation factor 4 gamma, 3"]
[8732,"RNGTT ","RNA guanylyltransferase and 5'-phosphatase"]
[9353,"SLIT2 ","slit homolog 2 (Drosophila)"]
[9462,"RASAL2 ","RAS protein activator like 2"]
[9472,"AKAP6 ","A kinase (PRKA) anchor protein 6"]
[9482,"STX8 ","syntaxin 8"]
[9577,"BRE ","brain and reproductive organ-expressed (TNFRSF1A modulator)"]
[9736,"USP34 ","ubiquitin specific peptidase 34"]
[9779,"TBC1D5 ","TBC1 domain family, member 5"]
[9832,"JAKMIP2 ","Janus kinase and microtubule interacting protein 2"]
[9844,"ELMO1","engulfment and cell motility 1"]
[9873,"FCHSD2 ","FCH and double SH3 domains 2"]
[10000,"AKT3 ","v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)"]
[10082,"GPC6 ","glypican 6"]
[10090,"UST ","uronyl-2-sulfotransferase"]
[10186,"LHFP ","lipoma HMGIC fusion partner"]
[10257,"ABCC4 ","ATP-binding cassette, sub-family C (CFTR/MRP), member 4"]
[10274,"STAG1 ","stromal antigen 1"]
[10371,"SEMA3A ","sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A"]
[10466,"COG5 ","component of oligomeric golgi complex 5"]
[10495,"ENOX2 ","ecto-NOX disulfide-thiol exchanger 2"]
[10667,"FARS2 ","phenylalanyl-tRNA synthetase 2, mitochondrial"]
[10973,"ASCC3 ","activating signal cointegrator 1 complex subunit 3"]
[11069,"RAPGEF4 ","Rap guanine nucleotide exchange factor (GEF) 4"]
[11278,"KLF12 ","Kruppel-like factor 12"]
[23024,"PDZRN3 ","PDZ domain containing ring finger 3"]
[23043,"TNIK ","TRAF2 and NCK interacting kinase"]
[23078,"KIAA0564 ","KIAA0564"]
[23081,"KDM4C ","lysine (K)-specific demethylase 4C"]
[23085,"ERC1 ","ELKS/RAB6-interacting/CAST family member 1"]
[23092,"ARHGAP26 ","Rho GTPase activating protein 26"]
[23097,"CDK19 ","cyclin-dependent kinase 19 "]
[23233,"EXOC6B ","exocyst complex component 6B"]
[23236,"PLCB1 ","phospholipase C, beta 1 (phosphoinositide-specific)"]
[23301,"EHBP1 ","EH domain binding protein 1"]
[23321,"TRIM2 ","tripartite motif-containing 2"]
[23348,"DOCK9 ","dedicator of cytokinesis 9"]
[23362,"PSD3 ","pleckstrin and Sec7 domain containing 3"]
[23389,"MED13L ","mediator complex subunit 13-like"]
[23505,"TMEM131 ","transmembrane protein 131"]
[23514,"KIAA0146 ","KIAA0146"]
[23522,"MYST4 ","MYST histone acetyltransferase (monocytic leukemia) 4"]
[23635,"SSBP2 ","single-stranded DNA binding protein 2"]
[26037,"SIPA1L1 ","signal-induced proliferation-associated 1 like 1"]
[26115,"TANC2 ","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2"]
[26610,"ELP4 ","elongation protein 4 homolog (S. cerevisiae)"]
[27044,"SND1 ","staphylococcal nuclease and tudor domain containing 1"]
[27241,"BBS9 ","Bardet-Biedl syndrome 9"]
[27303,"RBMS3 ","RNA binding motif, single stranded interacting protein"]
[27347,"STK39 ","serine threonine kinase 39 (STE20/SPS1 homolog, yeast)"]
[28232,"SLCO3A1 ","solute carrier organic anion transporter family, member 3A1"]
[28996,"HIPK2 ","homeodomain interacting protein kinase 2"]
[49855,"SCAPER ","S-phase cyclin A-associated protein in the ER"]
[50807,"ASAP1 ","ArfGAP with SH3 domain, ankyrin repeat and PH domain 1"]
[51194,"IPO11 ","importin 11"]
[51196,"PLCE1 ","phospholipase C, epsilon 1"]
[51319,"RSRC1 ","arginine/serine-rich coiled-coil 1"]
[51454,"GULP1 ","GULP, engulfment adaptor PTB domain containing 1"]
[51594,"NBAS ","neuroblastoma amplified sequence"]
[54541,"DDIT4 ","DNA-damage-inducible transcript 4"]
[54622,"ARL15 ","ADP-ribosylation factor-like 15"]
[54808,"DYM ","dymeclin"]
[54828,"BCAS3 ","breast carcinoma amplified sequence 3"]
[54901,"CDKAL1 ","CDK5 regulatory subunit associated protein 1-like 1"]
[54927,"CHCHD3 ","coiled-coil-helix-coiled-coil-helix domain containing 3"]
[55016,"MARCH1","membrane-associated ring finger (C3HC4) 1"]
[55366,"LGR4 ","leucine-rich repeat-containing G protein-coupled receptor 4"]
[55604,"LRRC16A ","leucine rich repeat containing 16A"]
[55607,"PPP1R9A ","protein phosphatase 1, regulatory (inhibitor) subunit 9A"]
[55870,"ASH1L ","ash1 (absent, small, or homeotic)-like (Drosophila)"]
[56288,"PARD3 ","par-3 partitioning defective 3 homolog (C. elegans)"]
[56907,"SPIRE1 ","spire homolog 1 (Drosophila)"]
[56995,"TULP4 ","tubby like protein 4"]
[57094,"CPA6 ","carboxypeptidase A6"]
[57107,"PDSS2 ","prenyl (decaprenyl) diphosphate synthase, subunit 2"]
[57178,"ZMIZ1 ","zinc finger, MIZ-type containing 1"]
[57451,"ODZ2 ","odz, odd Oz/ten-m homolog 2 (Drosophila)"]
[57502,"NLGN4X ","neuroligin 4, X-linked"]
[57609,"DIP2B ","DIP2 disco-interacting protein 2 homolog B (Drosophila)"]
[58508,"MLL3 ","myeloid/lymphoid or mixed-lineage leukemia 3"]
[60412,"EXOC4 ","exocyst complex component 4"]
[60685,"ZFAND3 ","zinc finger, AN1-type domain 3"]
[63971,"KIF13A ","kinesin family member 13A"]
[64409,"WBSCR17 ","Williams-Beuren syndrome chromosome region 17"]
[64754,"SMYD3 ","SET and MYND domain containing 3"]
[64764,"CREB3L2 ","cAMP responsive element binding protein 3-like 2"]
[64778,"FNDC3B ","fibronectin type III domain containing 3B"]
[65084,"TMEM135 ","transmembrane protein 135"]
[79068,"FTO ","fat mass and obesity associated"]
[79071,"ELOVL6 ","ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)"]
[79096,"C11orf49 ","chromosome 11 open reading frame 49"]
[79109,"MAPKAP1 ","mitogen-activated protein kinase associated protein 1"]
[79712,"GTDC1 ","glycosyltransferase-like domain containing 1"]
[79772,"MCTP1 ","multiple C2 domains, transmembrane 1"]
[79834,"SGK269 ","NKF3 kinase family member"]
[80114,"BICC1 ","bicaudal C homolog 1 (Drosophila)"]
[81617,"CAB39L ","calcium binding protein 39-like"]
[81846,"SBF2 ","SET binding factor 2"]
[83734,"ATG10 ","ATG10 autophagy related 10 homolog (S. cerevisiae)"]
[83989,"FAM172A ","family with sequence similarity 172, member A"]
[84083,"ZRANB3 ","zinc finger, RAN-binding domain containing 3"]
[84216,"TMEM117 ","transmembrane protein 117"]
[84319,"C3orf26 ","chromosome 3 open reading frame 26"]
[84441,"MAML2 ","mastermind-like 2 (Drosophila)"]
[84978,"FRMD5 ","FERM domain containing 5"]
[85440,"DOCK7 ","dedicator of cytokinesis 7"]
[85461,"TANC1 ","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1"]
[89796,"NAV1 ","neuron navigator 1"]
[89797,"NAV2 ","neuron navigator 2"]
[114793,"FMNL2 ","formin-like 2"]
[114884,"OSBPL10 ","oxysterol binding protein-like 10"]
[120114,"FAT3 ","FAT tumor suppressor homolog 3 (Drosophila)"]
[124540,"MSI2 ","musashi homolog 2 (Drosophila)"]
[130507,"UBR3 ","ubiquitin protein ligase E3 component n-recognin 3 (putative)"]
[154664,"ABCA13 ","ATP-binding cassette, sub-family A (ABC1), member 13"]
[157680,"VPS13B ","vacuolar protein sorting 13 homolog B (yeast)"]
[169792,"GLIS3 ","GLIS family zinc finger 3"]
[201266,"SLC39A11 ","solute carrier family 39 (metal ion transporter), member 11"]
[220965,"FAM13C ","family with sequence similarity 13, member C"]
[221895,"JAZF1 ","JAZF zinc finger 1"]
[222255,"ATXN7L1 ","ataxin 7-like 1"]
[257019,"FRMD3 ","FERM domain containing 3"]
[285527,"FRYL ","FRY-like"]
["6 upregulated genes"]
[116039,"OSR2 ","odd-skipped related 2 (Drosophila)"]
[1839,"HBEGF ","heparin-binding EGF-like growth factor"]
[55879,"GABRQ ","gamma-aminobutyric acid (GABA) receptor, theta"]
[284391,"ZNF844 ","zinc finger protein 844"]
[26045,"LRRTM2 ","leucine rich repeat transmembrane neuronal 2"]
[116238,"TLCD1 ","TLC domain containing 1"]
["The genome-wide gene expression profile was studied on Human Gene 1.0 ST array in U373MG cells following a 24 hour-exposure to the vehicle (DMSO) or the compounds 1a,  2a or 3 at the concentration of IC50. The fold changes smaller than 0.3333, calculated by the expression levels in the compound-treated cells divided by those in the vehicle-treated cells, are considered as substantial downregulation. The set of 196 downregulated genes and 6 upregulated genes in U373MG cells shared among treatment with the compounds 1a, 2a, and 3 are listed with Entez Gene ID, gene symbol, and gene name. When the difference was compared between the vehicle group (n = 3) and the treatment group (n = 3) by Student t- test, the set of 16 downregulated genes exhibiting p-value < 0.001 and fold change < 0.3333 are underlined."]