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[null,"Additional Table S2 Functional analysis of genes differentially expressed in shHIF cells in response to hypoxia as compared with control cells."]
["Category","Term ID","Term","Count","Genes"]
["KEGG UP","mmu04514","Cell adhesion molecules (CAMs)",9,"Jam2, H2-Bl, H2-DMb1, Sdc1, H2-DMb2, H2-Ab1, Sdc2, H2-M10.1, Jam3, "]
[null,"mmu04010","MAPK signaling pathway",6,"Cdc42, Ppm1a, Pla2g5, B230120H23Rik, Ikbkg, Tgfb3, "]
[null,"mmu04612","Antigen processing and presentation",5,"H2-Bl, H2-DMb1, H2-DMb2, H2-Ab1, H2-M10.1, "]
[null,"mmu00010","Glycolysis / Gluconeogenesis",4,"Bpgm, Aldh3a2, Aldh3a1, Pdha1, "]
[null,"mmu04530","Tight junction",4,"Cdc42, Jam2, B230120H23Rik, Jam3, "]
[null,"mmu04330","Notch signaling pathway",3,"Dvl1, Mfng, Aph1a, "]
[null,"mmu05212","Pancreatic cancer",3,"Cdc42, Ikbkg, Tgfb3, "]
[null,"mmu05210","Colorectal cancer",3,"Dvl1, Fzd4, Tgfb3, "]
[null,"mmu04512","ECM-receptor interaction",3,"Thbs1, Sdc1, Sdc2, "]
[null,"mmu04350","TGF-beta signaling pathway",3,"Thbs1, Acvr1, Tgfb3, "]
[null,"mmu01030","Glycan structures - biosynthesis 1",3,"B4galt4, Extl1, Man1a2, "]
[null,"mmu04110","Cell cycle",3,"Ccne1, Ywhaq, Tgfb3, "]
[null,"mmu05217","Basal cell carcinoma",2,"Dvl1, Fzd4, "]
[null,"mmu01031","Glycan structures - biosynthesis 2",2,"B4galt4, Pigk, "]
[null,"mmu04115","p53 signaling pathway",2,"Ccne1, Thbs1, "]
[null,"mmu05211","Renal cell carcinoma",2,"Cdc42, Tgfb3, "]
[null,"mmu04370","VEGF signaling pathway",2,"Cdc42, Pla2g5, "]
[null,"mmu04520","Adherens junction",2,"Cdc42, Acp1, "]
[null,"mmu04210","Apoptosis",2,"Irak4, Ikbkg, "]
[null,"mmu04310","Wnt signaling pathway",2,"Dvl1, Fzd4, "]
[null,"mmu04510","Focal adhesion",2,"Thbs1, Cdc42, "]
[null,"mmu04810","Regulation of actin cytoskeleton",2,"Pfn1, Cdc42, "]
["KEGG DOWN","mmu04110","Cell cycle",10,"Ywhah, Dbf4, Mcm4, Smad4, Ccnb2, Orc4l, Cdc25a, Skp2, Smad2, Pttg1, "]
[null,"mmu04310","Wnt signaling pathway",9,"Map3k7, Ppp2r1b, Fzd2, Smad4, Fzd6, Tcf7l2, Frat2, Smad2, Plcb3, "]
[null,"mmu04010","MAPK signaling pathway",9,"Map4k4, Map3k7, Raf1, Mapk8ip1, Rps6ka1, Map3k7ip1, Mknk2, Map2k7, Mapk7, "]
[null,"mmu04910","Insulin signaling pathway",8,"Srebf1, Fasn, Fbp1, Raf1, Ppp1r3c, Pik3cd, Pfkp, Mknk2, "]
[null,"mmu04520","Adherens junction",7,"Map3k7, Wasl, Smad4, Tcf7l2, Erbb2, Baiap2, Smad2, "]
[null,"mmu00010","Glycolysis / Gluconeogenesis",6,"Fbp1, Hk2, Gpi1, EG433182, Pfkp, Acss1, "]
[null,"mmu04120","Ubiquitin mediated proteolysis",6,"Ube2z, Pias1, Cul3, Ddb1, Pias2, Skp2, "]
[null,"mmu04540","Gap junction",5,"Raf1, Csnk1d, Adrb1, Mapk7, Plcb3, "]
[null,"mmu04350","TGF-beta signaling pathway",5,"Ppp2r1b, Acvr2b, Smad4, Ltbp1, Smad2, "]
[null,"mmu04510","Focal adhesion",5,"Bcar1, Raf1, Zyx, Pik3cd, Erbb2, "]
[null,"mmu04810","Regulation of actin cytoskeleton",5,"Bcar1, Raf1, Wasl, Pik3cd, Baiap2, "]
[null,"mmu04012","ErbB signaling pathway",4,"Raf1, Pik3cd, Erbb2, Map2k7, "]
[null,"mmu04630","Jak-STAT signaling pathway",4,"Pias1, Pik3cd, Zfp91, Pias2, "]
[null,"mmu04150","mTOR signaling pathway",3,"Hif1a, Pik3cd, Rps6ka1, "]
[null,"mmu04115","p53 signaling pathway",3,"Casp8, Ccng2, Ccnb2, "]
[null,"mmu04210","Apoptosis",3,"Ripk1, Pik3cd, Casp8, "]
[null,"mmu04530","Tight junction",3,"Ppp2r1b, Tjp2, Spna2, "]
[null,"mmu01430","Cell Communication",3,"Col17a1, Gjc1, Lmnb2, "]
[null,"mmu04020","Calcium signaling pathway",3,"Adrb1, Erbb2, Plcb3, "]
[null,"mmu05214","Glioma",2,"Raf1, Pik3cd, "]
[null,"mmu04370","VEGF signaling pathway",2,"Raf1, Pik3cd, "]
[null,"mmu03320","PPAR signaling pathway",2,"Rxra, Dbi, "]
[null,"mmu04514","Cell adhesion molecules (CAMs)",1,"Vcan, "]
[null,"mmu04512","ECM-receptor interaction",1,"Hmmr, "]
["GO Biological Process UP","GO:0045449","regulation of transcription",30,"Tsc22d3, Morf4l2, Prdm5, Dbp, Nfe2l3, Ikbkg, Prrx2, Phf10, Tal1, Rnf141, Mycl1, Mdfic, Phf17, Wwp1, Acvr1, Zscan22, Zfp64, Scx, Phf8, Sod2, Rnf14, Dach2, Sirt2, Vdr, Pfn1, Zxdc, Atf5, Yaf2, Csde1, Rab18, "]
[null,"GO:0000902","cell morphogenesis",14,"Morf4l2, Gas7, Capzb, Cdc42, Ttl, Myo7a, Chpt1, Kazald1, Tgfb3, Gdnf, Igfbp6, Dvl1, Ndrg3, Ppt1, "]
[null,"GO:0042981","regulation of apoptosis",12,"Tm2d1, Tsc22d3, Gdnf, Bik, Plekhf1, H2-Bl, Sod2, Atf5, Card10, Ppt1, B230120H23Rik, 1110007C09Rik, "]
[null,"GO:0007010","cytoskeleton organization and biogenesis",12,"Fhod3, Pfn1, Gas7, Cdc42, Capzb, Mid1ip1, Ttl, Dync1li1, Myo7a, B230120H23Rik, Epb4.9, Snap23, "]
[null,"GO:0007166","cell surface receptor linked signal transduction",12,"V1rd14, Gdnf, Gnb4, Frzb, Irak4, Rgs16, Hs1bp3, Dvl1, Aph1a, Acvr1, Lmbr1, Fzd4, "]
[null,"GO:0006259","DNA metabolic process",11,"Ccne1, Morf4l2, Wrnip1, Hist1h2bb, Hist3h2a, H2afx, Nap1l2, Hist1h2bg, Sod2, Ppt1, Sirt2, "]
[null,"GO:0008610","lipid biosynthetic process",9,"Cyp7b1, Tm7sf2, Fads3, Cyb5r1, Elovl1, Pigk, Stard5, Chpt1, Elovl4, "]
[null,"GO:0051276","chromosome organization and biogenesis",8,"Morf4l2, Hist1h2bb, Hist3h2a, H2afx, Nap1l2, Hist1h2bg, Chpt1, Sirt2, "]
[null,"GO:0006897","endocytosis",7,"Rab34, Pacsin2, Myo7a, C3, Ppt1, Sh3kbp1, Rab4a, "]
[null,"GO:0001558","regulation of cell growth",6,"Morf4l2, Igfbp6, Ppt1, Ndrg3, Kazald1, Chpt1, "]
[null,"GO:0031497","chromatin assembly",6,"Hist1h2bb, Hist3h2a, H2afx, Nap1l2, Hist1h2bg, Sirt2, "]
[null,"GO:0051726","regulation of cell cycle",6,"Ccne1, Frk, H2afx, Atf5, B230120H23Rik, Sirt2, "]
[null,"GO:0006520","amino acid metabolic process",6,"Psph, Gldc, Sars, Bckdhb, Srr, Cth, "]
[null,"GO:0065004","protein-DNA complex assembly",5,"Hist1h2bb, Hist3h2a, H2afx, Nap1l2, Hist1h2bg, "]
[null,"GO:0006954","inflammatory response",5,"Thbs1, Tlr4, Saal1, C3, Acvr1, "]
[null,"GO:0009165","nucleotide biosynthetic process",5,"Atp6v1g1, Thtpa, Atp6v0e2, G6pdx, Atp6ap1, "]
[null,"GO:0008154","actin polymerization and/or depolymerization",4,"Pfn1, Gas7, Capzb, Epb4.9, "]
[null,"GO:0006366","transcription from RNA polymerase II promoter",4,"Pfn1, Sod2, Atf5, Rnf14, "]
[null,"GO:0006281","DNA repair",3,"Wrnip1, H2afx, Sod2, "]
[null,"GO:0016477","cell migration",3,"Gdnf, Clic4, Acvr1, "]
[null,"GO:0006417","regulation of translation",3,"Eif5, Tlr4, Eif2s1, "]
[null,"GO:0008064","regulation of actin polymerization and/or depolymerization",3,"Pfn1, Capzb, Epb4.9, "]
[null,"GO:0001525","angiogenesis",2,"Thbs1, Acvr1, "]
[null,"GO:0016458","gene silencing",2,"Brunol4, Sirt2, "]
[null,"GO:0030111","regulation of Wnt receptor signaling pathway",1,"Frzb, "]
[null,"GO:0030198","extracellular matrix organization and biogenesis",1,"Matn3, "]
["GO Biological Process DOWN","GO:0043067","regulation of programmed cell death",22,"Map3k7, Rrn3, Kitl, Api5, Traf4, Bnip3, Zfp91, Ripk3, Ywhah, Bcar1, Opa1, Casp8ap2, Hif1a, Mbd4, Mnt, Bard1, Casp8, Mapk8ip1, Cd24a, Stambp, Bcl2l13, Skp2, "]
[null,"GO:0006366","transcription from RNA polymerase II promoter",18,"Med7, Gabpa, Fus, Cnot7, Smad4, Nfx1, Tcf7l2, Foxm1, Mbd2, Olig2, Meis1, Rxra, Hif1a, Sin3a, Suz12, Ttf1, Zfpm2, Smad2, "]
[null,"GO:0007155","cell adhesion",17,"Ncan, Gatad2a, Kitl, Col17a1, Twist1, Dgcr2, Fzd6, Ttyh1, Fblim1, Tro, Bcar1, Zyx, Obsl1, Dst, Cd24a, Col9a1, Vcan, "]
[null,"GO:0006512","ubiquitin cycle",17,"Ube2z, Pcnp, Uchl1, Cul3, Sumf1, Pias2, Usp19, Topors, Rnf145, Pias1, Socs6, Usp21, Suz12, Ddb1, Stambp, Usp20, Skp2, "]
[null,"GO:0051276","chromosome organization and biogenesis",16,"Rad21, Ncapd2, Ing3, Pcgf2, Blm, Bnip3, H2afy, Jmjd1a, Suz12, Ttf1, Hmgn1, Smc3, Chd4, Jarid1b, Pttg1, Mphosph8, "]
[null,"GO:0006412","translation",16,"Rad21, Paip2b, Iars2, Eif2ak1, Nfx1, Mknk2, Tia1, Rps20, Eftud2, EG625603, Eif4g1, Eif4ebp2, Tnfrsf13c, Eif5b, Gspt1, Mrpl15, "]
[null,"GO:0007010","cytoskeleton organization and biogenesis",14,"Uchl1, Raf1, Wasl, Dbn1, Kif11, Kif23, Ywhah, Bcar1, Opa1, Spna2, Dst, Myo5a, Smc3, Dbnl, "]
[null,"GO:0006974","response to DNA damage stimulus",14,"Rad50, Rad21, Timeless, Rad52, Blm, Trp53bp1, Tdg, Topors, Mbd4, Hmgn1, Smc3, Poli, Pttg1, Rif1, "]
[null,"GO:0006281","DNA repair",11,"Rad50, Rad21, Tdg, Rad52, Mbd4, Hmgn1, Blm, Trp53bp1, Smc3, Poli, Pttg1, "]
[null,"GO:0051726","regulation of cell cycle",11,"Ywhah, Mnt, Dbf4, Dst, Rassf5, Ccng2, Erbb2, Ccnb2, Nek6, Psmd1, Skp2, "]
[null,"GO:0006260","DNA replication",10,"Top3a, Helb, Tdg, Dbf4, Mcm4, Rfc1, Ttf1, Blm, Poli, Orc4l, "]
[null,"GO:0016477","cell migration",9,"Ank3, Ephb3, Bcar1, Kitl, Hif1a, Twist1, Cd24a, Erbb2, Gipc1, "]
[null,"GO:0007249","I-kappaB kinase/NF-kappaB cascade",7,"Map3k7, Ripk1, Casp8, Ikbke, Nek6, Erc1, Ripk3, "]
[null,"GO:0006897","endocytosis",7,"Ap1g1, Ap1b1, Abca7, Clcn5, Cd24a, Dbnl, EG621324, "]
[null,"GO:0000165","MAPKKK cascade",6,"Map3k11, Map3k7, Mapk8ip1, Cd24a, Map3k7ip1, Map2k7, "]
[null,"GO:0001525","angiogenesis",6,"Map3k7, Serpinf1, Hif1a, Casp8, Erbb2, Mapk7, "]
[null,"GO:0007265","Ras protein signal transduction",6,"E130112L23Rik, Kitl, Baiap2, Als2, Dbnl, Tbc1d24, "]
[null,"GO:0030029","actin filament-based process",6,"Bcar1, Wasl, Spna2, Dbn1, Myo5a, Dbnl, "]
[null,"GO:0051056","regulation of small GTPase mediated signal transduction",6,"E130112L23Rik, Kitl, Rasa4, Als2, Rgl1, Tbc1d24, "]
[null,"GO:0043123","positive regulation of I-kappaB kinase/NF-kappaB cascade",5,"Map3k7, Ripk1, Casp8, Ikbke, Nek6, "]
[null,"GO:0007179","transforming growth factor beta receptor signaling pathway",5,"Map3k7, Smad4, Map3k7ip1, Ltbp1, Smad2, "]
[null,"GO:0016055","Wnt receptor signaling pathway",5,"Fzd2, Fzd6, Tcf7l2, Csnk1d, Frat2, "]
[null,"GO:0016337","cell-cell adhesion",5,"Gatad2a, Twist1, Fzd6, Cd24a, Ttyh1, "]
[null,"GO:0001666","response to hypoxia",3,"Hif1a, Cd24a, Bnip3, "]
[null,"GO:0007254","JNK cascade",3,"Map3k11, Map3k7, Mapk8ip1, "]
[null,"GO:0007015","actin filament organization",3,"Bcar1, Dbn1, Dbnl, "]