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{"sheet":"Sheet1","index":0,"n_rows":134,"n_cols":6,"rows_kept":134,"merged":[[99,0,99,5],[99,0,99,5],[115,0,115,5],[118,0,118,5]],"flags":["formulas_cached_only"]}
["Additional File 2. Relative transcript levels of key macrophage genes modulated by Mtb infection."]
["Gene","ID","Gene assignment","CDC1551","HN878","Ratio (C/H)"]
["(1) Highly expressed genes by CDC1551 infection (6 h)"]
["Immune response"]
["Cxcl9","NM_008599","T cell chemoattractant",100.45,26.29,3.82]
["Cxcl11","NM_019494","chemokine (C-X-C motif) ligand 11",38.64,{"v":10.8,"d":"10.80"},3.58]
["Serpina3f","NM_001033335","serine (or cysteine) peptidase inhibitor, clade A, ",{"v":58.3,"d":"58.30"},16.22,3.59]
["Serpine1","NM_008871","serine (or cysteine) peptidase inhibitor, clade E",12.72,4.19,3.04]
["Nos2","NM_010927","nitric oxide synthase 2",78.41,25.97,3.02]
["Edn1","NM_010104","endothelin 1",109.95,36.52,3.01]
["Sell","NM_011346","selectin L,  Leukocyte-endothelial cell adhesion molecule",9.67,3.37,2.87]
["Gbp4","NM_008620","guanylate binding protein 4",65.77,{"v":23.3,"d":"23.30"},2.82]
["Il10","NM_010548","interleukin 10",12.22,5.02,2.43]
["Slfn4","NM_011410","schlafen 4",38.32,17.27,2.22]
["Iigp1","NM_001146275","interferon inducible GTPase 1 ",65.55,30.01,2.18]
["Tnfsf10","NM_009425","tumor necrosis factor (ligand) superfamily, member 10",51.45,24.05,2.14]
["Nfil3","NM_017373","nuclear factor, interleukin 3, regulated",3.91,1.83,2.13]
["Slamf1","NM_013730 ","signaling lymphocytic activation molecule family member 1",18.05,{"v":8.5,"d":"8.50"},2.12]
["Serpina3h","NM_001034870","serine (or cysteine) peptidase inhibitor, clade A, ",5.05,2.44,2.07]
["Ccl8","NM_021443","chemokine (C-C motif) ligand 8",{"v":16,"d":"16.00"},7.78,2.06]
["Il18rap","NM_010553","interleukin 18 receptor accessory protein",2.29,1.11,2.05]
["Tissue remodeling"]
["Mmp25","NM_001033339","matrix metallopeptidase 25, membrane",10.89,3.86,2.82]
["Mmp13","NM_008607","matrix metallopeptidase 13, membrane",45.35,19.12,2.37]
["Metabolism"]
["Lipg","NM_010720","Endothelial lipase",{"v":39.9,"d":"39.90"},9.72,4.11]
["Upp1","NM_009477","uridine phosphorylase 1",4.11,1.65,2.49]
["Pfkfb3","NM_133232 ","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3",10.29,4.35,2.36]
["Hdc","NM_008230 ","histidine decarboxylase",15.62,6.76,2.31]
["Pla2g4a","NM_008869","phospholipase A2, group IVA (cytosolic, Ca2+ dependent)",6.14,2.79,{"v":2.2,"d":"2.20"}]
["Aldh1b1","NM_028270","aldehyde dehydrogenase 1 family, member B1 ",4.73,2.21,2.14]
["Kdsr","NM_027534 ","3-ketodihydrosphingosine reductase",-4.31,-2.12,2.03]
["Signal transduction"]
["Fst","NM_008046","Follistatin",3.25,1.42,2.28]
["Gpr31c","NM_001013832","G protein-coupled receptor 31, D17Leh66c region",{"v":24.9,"d":"24.90"},11.64,2.14]
["Sos1","NM_009231","son of sevenless homolog 1 (Drosophila) ",4.37,2.17,2.02]
["Cell growth, development and death"]
["Cnn3","NM_028044","calponin 3, acidic",6.82,1.82,3.75]
["Ccnd2","NM_009829","cyclin D2",15.23,4.98,3.06]
["Vcan","NM_001081249","Versican",26.19,10.17,2.57]
["Armcx6","NM_001007578","armadillo repeat containing, X-linked 6",3.89,1.63,2.38]
["Lhx2","NM_010710","LIM homeobox protein 2",4.76,2.12,2.25]
["Tle3","NM_001083927","transducin-like enhancer of split 3",2.88,1.33,2.16]
["Lcn2","NM_008491","lipocalin 2",25.43,{"v":11.8,"d":"11.80"},2.15]
["Biological process"]
["Hmgn3","NM_026122","high mobility group nucleosomal binding domain 3 ",10.54,4.79,{"v":2.2,"d":"2.20"}]
["Abtb2","NM_178890","ankyrin repeat and BTB (POZ) domain containing 2",6.71,3.25,2.07]
["Mxd1","NM_010751","MAX dimerization protein 1 ",6.65,3.23,2.06]
["(2) Highly expressed genes by HN878 infection (6 h)"]
["Metabolism"]
["Hsd17b7","NM_010476","hydroxysteroid (17-beta) dehydrogenase 7",2.06,7.89,0.26]
["Fdft1","BC138301","farnesyl diphosphate farnesyl transferase 1",1.19,3.89,{"v":0.3,"d":"0.30"}]
["Hmgcs1","NM_145942","3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1",1.06,3.17,0.33]
["Cyp51","NM_020010","cytochrome P450, family 51 ",1.53,4.28,0.36]
["Idi1","NM_145360 ","isopentenyl-diphosphate delta isomerase ",1.73,4.29,{"v":0.4,"d":"0.40"}]
["Snhg1","AK051045","small nucleolar RNA host gene (non-protein coding) 1",1.46,3.61,0.41]
["Insig1","NM_153526","insulin induced gene 1",1.24,3.01,0.41]
["Hmgcr","NM_008255","3-hydroxy-3-methylglutaryl-Coenzyme A reductase",1.83,4.35,0.42]
["Mmp9","NM_013599","metalloproteinase 9",1.69,3.99,0.42]
["Sc5d","NM_172769 ","sterol-C5-desaturase ",1.45,3.27,0.44]
["Maff","NM_010755","v-maf musculoaponeurotic fibrosarcoma oncogene family",2.94,6.25,0.47]
["Plk3","NM_013807","polo-like kinase 3",1.29,2.74,0.47]
["Ldlr","NM_010700","low density lipoprotein receptor",1.82,3.81,0.48]
["Asns","NM_012055","asparagine synthetase",1.13,2.25,{"v":0.5,"d":"0.50"}]
["Tmem97","NM_133706","transmembrane protein 97, cholesterol homeostasis",-2.33,-1.17,{"v":2,"d":"2.00"}]
["Gnpda1","NM_011937","glucosamine-6-phosphate deaminase 1",-9.06,-4.01,2.26]
["Dhcr7","NM_007856","7-dehydrocholesterol reductase",-3.72,-1.64,2.28]
["Mid1ip1","NM_026524","Mid1 interacting protein 1 ",-3.84,-1.66,2.31]
["Cell growth and death"]
["Arrb1","NM_177231","arrestin, beta 1",-7.28,-2.94,2.48]
["Mapk14","NM_011951","mitogen-activated protein kinase 14 ",-3.78,{"v":-1.6,"d":"-1.60"},2.36]
["Sesn1","NM_001013370","sestrin N1",-9.81,-4.44,2.21]
["Ddx26b","NM_172779","DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B ",-9.01,-4.48,2.01]
["Gas5","NR_002840","growth arrest specific 5",1.16,2.38,0.49]
["Signal transduction"]
["Pdxk","NM_172134","pyridoxal (pyridoxine, vitamin B6) kinase",-6.03,-2.62,{"v":2.3,"d":"2.30"}]
["Gpr65","NM_008152","G-protein coupled receptor 65",-3.24,-1.48,2.19]
["Wdr12","NM_021312","WD repeat domain 12 ",-2.48,-1.14,2.18]
["Pgap1","NC_000067.5","post-GPI attachment to proteins 1",-3.34,-1.59,{"v":2.1,"d":"2.10"}]
["Rpp40","NM_145938","ribonuclease P 40 subunit (human) ",-2.05,-1.02,2.01]
["Snord37","AF357364 ","small nucleolar RNA, C/D box 37",1.09,2.26,0.48]
["Sdc1","NM_011519","syndecan 1 ",2.02,4.37,0.46]
["Biological process and molecule transport"]
["Tgfbr1","NM_009370","transforming growth factor, beta receptor I",-5.22,-2.05,2.54]
["Kcnj2","NM_008425","potassium inwardly-rectifying channel, subfamily J",-6.17,-2.43,2.54]
["Klhdc2","NM_027117 ","kelch domain containing 2 ",-3.93,-1.91,2.05]
["Nol8","NM_001081350","nucleolar protein 8 ",-2.23,-1.12,{"v":2,"d":"2.00"}]
["(3) Highly expressed genes by CDC1551 infection (24 h)"]
["Immune response"]
["Cxcl9","NM_008599","T cell chemoattractant",23.79,4.44,5.36]
["Sell","NM_011346","selectin L,  Leukocyte-endothelial cell adhesion molecule",{"v":8.3,"d":"8.30"},{"v":2.4,"d":"2.40"},3.45]
["Cxcl11","NM_019494","C-X-C chemokine 11",9.14,3.78,2.42]
["Slfn4","NM_011410","schlafen 4, regulation in macrophage activation",15.96,6.99,2.28]
["Cst7","NM_009977","cystatin F (leukocystatin)",8.74,3.99,2.19]
["Ccl8","NM_021443","C-C motif chomokine 8",{"v":3.3,"d":"3.30"},1.53,2.15]
["Biological process"]
["Lipg","NM_010720","endothelial lipase",2.12,1.02,2.06]
["Sirpb1","NM_001002898","signal regulatory protein β1",3.88,1.91,2.03]
["Cd244","NM_018729","natural killer cell receptor 2B4",7.29,3.65,{"v":2,"d":"2.00"}]
["(4) Highly expressed genes by HN878 infection (24 h)"]
["Immune response"]
["Cxcl3","NM_203320","Chomokine (C-X-C motif) ligand 3",2.04,16.26,0.13]
["Cd209f","NC_000074.5","Cd209f antigen, DC-SIGN",12.23,65.09,0.19]
["Il1b","NM_008361","interleukin 1 beta",2.94,15.54,0.19]
["Il1a","NM_010554","interleukin 1 alpha",5.13,26.33,0.19]
["Serpinb2","NM_011111","serine peptidase inhibitor 2",1.11,5.15,0.22]
["Cxcl2","NM_009140","C-X-C motif chemokine 2",1.65,6.78,0.24]
["Il6","NM_031168","interleukin 6",2.91,9.49,0.31]
["Cd209g","BC118542","Cd209g antigen",2.54,7.19,0.35]
["Cxcl5","NM_009141","C-X-C motif chemokine ligand 5",1.03,2.86,0.36]
["Susd2","NM_027890","sushi domain-2 containing",3.12,7.68,0.41]
["Cxcl1","NM_008176","Chemokine (C-X-C motif) ligand 1",1.24,2.65,0.47]
["Clec7a","NM_020008","C type lectin domain family 7",-17.35,-8.92,1.95]
["Emb","NM_010330","Embigin",-5.36,-2.34,2.29]
["Clec4n","NM_020001","C type lectin domain family 4",-7.92,-2.19,3.63]
["Tissue remodeling"]
["Mmp9","NM_013599","metalloproteinase 9",{"v":1.9,"d":"1.90"},7.91,0.24]
["Mmp12","NM_008605","metalloproteinase 12",-6.45,-2.74,2.36]
["Cell growth, development and death"]
["Vcan","NM_001081249","uncharacterized protein",1.04,2.58,{"v":0.4,"d":"0.40"}]
["Gja1","NM_010288","gap junction alpha-1 protein",2.16,{"v":5.1,"d":"5.10"},0.42]
["Hp","NM_017370","Haptoglobin",5.32,11.73,0.45]
["Nr4a1","NM_010444","Notch class gene",-4.98,-2.42,2.06]
["Egr2","NM_010118","early growth response 2, cell death",-4.14,-1.56,2.65]
["Thbs1","NM_011580","thrombospondin 1",{"v":-3,"d":"-3.00"},-1.06,2.83]
["Metabolism"]
["Ptgs2","NM_011198","prostaglandin-endoperoxide synthase 2",6.62,24.06,0.28]
["Fads2","NM_019699","fatty acid desaturase 2",1.25,3.69,0.34]
["Biological Process and molecule transport"]
["Slc7a11","NM_011990","solute carrier family 7a 11",2.39,9.14,0.26]
["H2-M2","NM_008204","histocompatibility 2  region M 2",3.08,{"v":8.3,"d":"8.30"},0.37]
["Slc7a2","NM_007514","solute carrier family 7a 2",2.68,6.96,0.39]
["Ak3l1","NM_009647","adenylate kinase 3-like 1",1.09,{"v":2.6,"d":"2.60"},0.42]
["Slc6a12","NM_133661","solute carrier family 6a 12",5.94,11.94,{"v":0.5,"d":"0.50"}]

{"sheet":"Sheet2","index":1,"n_rows":135,"n_cols":4,"rows_kept":135,"flags":["formulas_cached_only"]}
["Gene",null,"Gene assignment","Ratio (C/H)"]
["(1) Highly expressed genes by CDC1551 infection (6 h)"]
["Immune response"]
["Cxcl9",null,"T cell chemoattractant",3.82]
["Cxcl11",null,"chemokine (C-X-C motif) ligand 11",3.58]
["Ccl8",null,"chemokine (C-C motif) ligand 8",2.06]
["Il18rap",null,"interleukin 18 receptor accessory protein",2.05]
["Il10",null,"interleukin 10",2.43]
["Iigp1",null,"interferon inducible GTPase 1 ",2.18]
["Slfn4",null,"schlafen 4",2.22]
["Tnfsf10",null,"tumor necrosis factor (ligand) superfamily, member 10",2.14]
["Nos2",null,"nitric oxide synthase 2",3.02]
["Edn1",null,"endothelin 1",3.01]
["Sell",null,"selectin L,  Leukocyte-endothelial cell adhesion molecule",2.87]
["Nfil3",null,"nuclear factor, interleukin 3, regulated",2.13]
["Slamf1",null,"signaling lymphocytic activation molecule family member 1",2.12]
["Gbp4",null,"guanylate binding protein 4",2.82]
["Serpina3f",null,"serine (or cysteine) peptidase inhibitor, clade A, ",3.59]
["Serpine1",null,"serine (or cysteine) peptidase inhibitor, clade E",3.04]
["Serpina3h",null,"serine (or cysteine) peptidase inhibitor, clade A, ",2.07]
["Tissue remodeling"]
["Mmp13",null,"matrix metallopeptidase 13, membrane",2.37]
["Mmp25",null,"matrix metallopeptidase 25, membrane",2.82]
["Metabolism"]
["Pfkfb3",null,"6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3",2.36]
["Hdc",null,"histidine decarboxylase",2.31]
["Aldh1b1",null,"aldehyde dehydrogenase 1 family, member B1 ",2.14]
["Pla2g4a",null,"phospholipase A2, group IVA (cytosolic, Ca2+ dependent)",{"v":2.2,"d":"2.20"}]
["Kdsr",null,"3-ketodihydrosphingosine reductase",2.03]
["Upp1",null,"uridine phosphorylase 1",2.49]
["Lipg",null,"Endothelial lipase",4.11]
["Signal transduction"]
["Gpr31c",null,"G protein-coupled receptor 31, D17Leh66c region",2.14]
["Sos1",null,"son of sevenless homolog 1 (Drosophila) ",2.02]
["Fst",null,"Follistatin",2.28]
["Cell growth, development and death"]
["Lcn2",null,"lipocalin 2",2.15]
["Ccnd2",null,"cyclin D2",3.06]
["Lhx2",null,"LIM homeobox protein 2",2.25]
["Tle3",null,"transducin-like enhancer of split 3",2.16]
["Vcan",null,"Versican",2.57]
["Cnn3",null,"calponin 3, acidic",3.75]
["Biological process"]
["Hmgn3",null,"high mobility group nucleosomal binding domain 3 ",{"v":2.2,"d":"2.20"}]
["Abtb2",null,"ankyrin repeat and BTB (POZ) domain containing 2",2.07]
["Mxd1",null,"MAX dimerization protein 1 ",2.06]
["Armcx6",null,"armadillo repeat containing, X-linked 6",2.38]
[]
["(2) Highly expressed genes by HN878 infection (6 h)"]
["Metabolism"]
["Hsd17b7",null,"hydroxysteroid (17-beta) dehydrogenase 7",0.26]
["Fdft1",null,"farnesyl diphosphate farnesyl transferase 1",{"v":0.3,"d":"0.30"}]
["Hmgcs1",null,"3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1",0.33]
["Cyp51",null,"cytochrome P450, family 51 ",0.36]
["Idi1",null,"isopentenyl-diphosphate delta isomerase ",{"v":0.4,"d":"0.40"}]
["Hmgcr",null,"3-hydroxy-3-methylglutaryl-Coenzyme A reductase",0.42]
["Mmp9",null,"metalloproteinase 9",0.42]
["Sc5d",null,"sterol-C5-desaturase ",0.44]
["Sdc1",null,"syndecan 1 ",0.46]
["Maff",null,"v-maf musculoaponeurotic fibrosarcoma oncogene family",0.47]
["Plk3",null,"polo-like kinase 3",0.47]
["Ldlr",null,"low density lipoprotein receptor",0.48]
["Dhcr7",null,"7-dehydrocholesterol reductase",2.28]
["Tmem97",null,"transmembrane protein 97, cholesterol homeostasis",{"v":2,"d":"2.00"}]
["Asns",null,"asparagine synthetase",{"v":0.5,"d":"0.50"}]
["Gnpda1",null,"glucosamine-6-phosphate deaminase 1",2.26]
["Snhg1",null,"small nucleolar RNA host gene (non-protein coding) 1",0.41]
["Insig1",null,"insulin induced gene 1",0.41]
["Mid1ip1",null,"Mid1 interacting protein 1 ",2.31]
["Cell growth and death"]
["Arrb1",null,"arrestin, beta 1",2.48]
["Mapk14",null,"mitogen-activated protein kinase 14 ",2.36]
["Sesn1",null,"sestrin N1",2.21]
["Gas5",null,"growth arrest specific 5",0.49]
["Ddx26b",null,"DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B ",2.01]
["Signal transduction"]
["Gpr65",null,"G-protein coupled receptor 65",2.19]
["Wdr12",null,"WD repeat domain 12 ",2.18]
["Pgap1",null,"post-GPI attachment to proteins 1",{"v":2.1,"d":"2.10"}]
["Pdxk",null,"pyridoxal (pyridoxine, vitamin B6) kinase",{"v":2.3,"d":"2.30"}]
["Rpp40",null,"ribonuclease P 40 subunit (human) ",2.01]
["Snord37",null,"small nucleolar RNA, C/D box 37",0.48]
["Biological process and molecule transport"]
["Klhdc2",null,"kelch domain containing 2 ",2.05]
["Nol8",null,"nucleolar protein 8 ",{"v":2,"d":"2.00"}]
["Tgfbr1",null,"transforming growth factor, beta receptor I",2.54]
["Kcnj2",null,"potassium inwardly-rectifying channel, subfamily J",2.54]
[]
["(3) Highly expressed genes by CDC1551 infection (24 h)"]
["Immune response"]
["Cxcl9",null,"T cell chemoattractant",5.36]
["Sell",null,"selectin L,  Leukocyte-endothelial cell adhesion molecule",3.45]
["Cxcl11",null,"C-X-C chemokine 11",2.42]
["Slfn4",null,"schlafen 4, regulation in macrophage activation",2.28]
["Cst7",null,"cystatin F (leukocystatin)",2.19]
["Ccl8",null,"C-C motif chomokine 8",2.15]
["Biological process"]
["Lipg",null,"endothelial lipase",2.06]
["Sirpb1",null,"signal regulatory protein β1",2.03]
["Cd244",null,"natural killer cell receptor 2B4",{"v":2,"d":"2.00"}]
[]
["(4) Highly expressed genes by HN878 infection (24 h)"]
["Immune response"]
["Il1b",null,"interleukin 1 beta",0.19]
["Il1a",null,"interleukin 1 alpha",0.19]
["Il6",null,"interleukin 6",0.31]
["Cxcl1",null,"Chemokine (C-X-C motif) ligand 1",0.47]
["Cxcl2",null,"C-X-C motif chemokine 2",0.24]
["Cxcl3",null,"Chomokine (C-X-C motif) ligand 3",0.13]
["Cxcl5",null,"C-X-C motif chemokine ligand 5",0.36]
["Serpinb2",null,"serine peptidase inhibitor 2",0.22]
["Susd2",null,"sushi domain-2 containing",0.41]
["Cd209f",null,"Cd209f antigen, DC-SIGN",0.19]
["Cd209g",null,"Cd209g antigen",0.35]
["Clec7a",null,"C type lectin domain family 7",1.95]
["Clec4n",null,"C type lectin domain family 4",3.63]
["Emb",null,"Embigin",2.29]
["Tissue remodeling"]
["Mmp9",null,"metalloproteinase 9",0.24]
["Mmp12",null,"metalloproteinase 12",2.36]
["Cell growth, development and death"]
["Gja1",null,"gap junction alpha-1 protein",0.42]
["Hp",null,"Haptoglobin",0.45]
["Thbs1",null,"thrombospondin 1",2.83]
["Nr4a1",null,"Notch class gene",2.06]
["Egr2",null,"early growth response 2, cell death",2.65]
["Vcan",null,"uncharacterized protein",{"v":0.4,"d":"0.40"}]
["Biological Process and molecule transport"]
["H2-M2",null,"histocompatibility 2  region M 2",0.37]
["Ptgs2",null,"prostaglandin-endoperoxide synthase 2",0.28]
["Fads2",null,"fatty acid desaturase 2",0.34]
["Ak3l1",null,"adenylate kinase 3-like 1",0.42]
["Slc7a2",null,"solute carrier family 7a 2",0.39]
["Slc7a11",null,"solute carrier family 7a 11",0.26]
["Slc6a12",null,"solute carrier family 6a 12",{"v":0.5,"d":"0.50"}]

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