{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Modifications of iMC1010v2","input signals","inactive genes and reactions"],"not_rendered":{"images":1,"external_links":1,"defined_names":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Modifications of iMC1010v2","index":0,"n_rows":60,"n_cols":3,"rows_kept":60,"flags":["formulas_cached_only"]}
{"$rows_empty":52}
["Fixed rules for Transcription Factor activities due to labeling problems according to Supplementary data of Covert et al (nature02456-s9.xls)"]
[]
["Regulator","bNumber","gene name"]
["CitA","b0619","dpiB"]
["CitB","b0620","dpiA"]
["Cra","b0080","fruR"]
["AllS","b0504","ybbS"]
["GutR","b2707","srlR"]

{"sheet":"input signals","index":1,"n_rows":136,"n_cols":5,"rows_kept":136,"flags":["formulas_cached_only"]}
["Input signals for the condition: Bioreactor MM+Glycerol aerobic growth",null,null,"condition Haverkorn glucose: shaking flask/chemostat M9 minimal medium +glucose, aerobic growth","condition Haverkorn galactose: shaking flask/chemostat M9 minimal medium +galactose, aerobic growth"]
[]
["Stringent","False"]
["high osmolarity","False"]
["heat shock","False"]
["Stress","True"]
["LBMedia","False"]
["Rich Medium","False"]
["Oxidative Stress","False"]
["Salicylate","False"]
["high NAD","False"]
["dipyridyl","False"]
["pH < 7","True"]
["pH < 4","False"]
["Growth>0","True"]
["glyc(e)>0","True",null,"False","False"]
["pyr(e)>0","False"]
["lac-D(e)>0","False"]
["lac-L(e)>0","False"]
["glc-D(e)>0","False",null,"True"]
["fru(e)>0","False"]
["g6p(e)>0","False"]
["gal(e)>0","False",null,null,"True"]
["ac(e)>0","False",null,"True","False"]
["for(e)>0","False"]
["for(e)>1","False"]
["succ(e)>0","False"]
["succ(e)>1","False"]
["fum(e)>0","False"]
["fum(e)>1","False"]
["mal-L(e)>0","False"]
["mal-L(e)>1","False"]
["arg-L(e)>0","False"]
["asp-L(e)>0","False"]
["ser-D(e)>0","False"]
["thr-L(e)>0","False"]
["ile-L(e)>0","False"]
["lys-L(e)>0","False"]
["leu-L(e)>0","False"]
["gln-L(e)>0","False"]
["glu-L(e)>0","False"]
["phe-L(e)>0","False"]
["phe-L(e)>10","False"]
["tyr-L(e)>0","False"]
["trp-L(e)>0","False"]
["ala-L(e)>0","False"]
["ala-D(e)>0","False"]
["cys-L(e)>0","False"]
["ser-L(e)>0","False"]
["val-L(e)>0","False"]
["his-L(e)>0","False"]
["pro-L(e)>0","False"]
["gly(e)>0","False"]
["met-L(e)>0","False"]
["glcr(e)>0","False"]
["arab-L(e)>0","False"]
["galct-D(e)>0","False"]
["chol(e)>0","False"]
["ppa(e)>0","False"]
["cynt(e)>0","False"]
["lcts(e)>0","False"]
["3hpppn(e)>0","False"]
["nh4(e)>0","False"]
["nh4(e)>2","True"]
["no3(e)>0","False"]
["no2(e)>0","False"]
["no3(e)>1","False"]
["no2(e)>1","False"]
["cit(e)>0","False"]
["gam(e)>0","False"]
["acgam(e)>0","False"]
["csn(e)>0","False"]
["malt(e)>0","False"]
["hxan(e)>0","False"]
["2ddglcn(e)>0","False"]
["cbi(e)>0","False"]
["ade(e)>0","False"]
["gua(e)>0","False"]
["thym(e)>0","False"]
["ura(e)>0","False"]
["galt(e)>0","False"]
["acac(e)>0","False"]
["xtsn(e)>0","False"]
["pppn(e)>0","False"]
["sbt-D(e)>0","False"]
["rmn(e)>0","False"]
["fuc-L(e)>0","False"]
["glyclt(e)>0","False"]
["tartr-L(e)>0","False"]
["malttr(e)>0","False"]
["maltttr(e)>0","False"]
["malthx(e)>0","False"]
["maltpt(e)>0","False"]
["glcn(e)>0","False"]
["xyl-D(e)>0","False"]
["mnl(e)>0","False"]
["galctn-D(e)>0","False"]
["asn-L(e)>0","False"]
["rib-D(e)>0","False"]
["cytd(e)>0","False"]
["h2o2(e)>0","False"]
["btn(e)>0","False"]
["melib(e)>0","False"]
["tre(e)>0","False"]
["idon-L(e)>0","False"]
["5dglcn(e)>0","False"]
["ins(e)>0","False"]
["ttdca(e)>0","False"]
["hdca(e)>0","False"]
["ocdca(e)>0","False"]
["asp-L(e)>1","False"]
["tmao(e)>1","False"]
["tmao(e)>0","False"]
["dmso(e)>1","False"]
["dmso(e)>0","False"]
["na1(e)>0","True"]
["o2(e)>0","True"]
["fe2(e)>0","True"]
["k(e)>1","True"]
["man(e)>0","False"]
["so4(e)>0","True"]
["pi(e)<0.004E-6 M","False"]
["AGDC>0","False","true if glucosamin is used as substrate. Needs to be true for murein-path of supplementary table 1"]
["PPM2>0","False","true if nucleotides are used as a substrate"]
["PPM2<0","False","true if ribonucleotides are build from glyceral-3-phoshate and acetaldehyd. Needs to be true for accoa-path of supplementary table 1"]
["GUI1<0","False"]
["GUI1>0","False"]
["GUI2<0","False"]
["GUI2>0","False"]
["MANAO>0","False"]
["MANAO<0","False"]
["TAGURr>0","False"]
["TAGURr<0","False"]
["Surplus FDP","False","true if internal fructosebisphosphate concentration is increased, e.g. if fructose is a substrate"]
["Surplus PYR","False","true if internal pyruvate concentration is increased, e.g. if lactate is a substrate"]
["none","True"]

{"sheet":"inactive genes and reactions","index":2,"n_rows":336,"n_cols":6,"rows_kept":336,"flags":["formulas_cached_only"]}
["In this table genes are not identifiers for the reactions in the same line!"]
[]
["Condition: Bioreactor MM+Glycerol aerobic growth",null,"Condition: MM+Glucose aerobic growth",null,"Condition: MM+Galactose aerobic growth"]
[]
["Inactive Genes","inactive reactions","Inactive Genes","inactive reactions","Inactive Genes","inactive reactions"]
["b0061","R_14GLUCANabcpp","b0034","R_14GLUCANabcpp","b0061","R_14GLUCANabcpp"]
["b0062","R_14GLUCANtexi","b0036","R_14GLUCANtexi","b0062","R_14GLUCANtexi"]
["b0063","R_3HCINNMH","b0038","R_3HCINNMH","b0063","R_3HCINNMH"]
["b0064","R_3HPPPNH","b0040","R_3HPPPNH","b0064","R_3HPPPNH"]
["b0124","R_5DGLCNR","b0061","R_42A12BOOXpp","b0124","R_5DGLCNR"]
["b0162","R_5DGLCNt2rpp","b0062","R_5DGLCNR","b0162","R_5DGLCNt2rpp"]
["b0312","R_ACACCT","b0063","R_5DGLCNt2rpp","b0312","R_ACACCT"]
["b0314","R_ACACT1r","b0064","R_ACACCT","b0314","R_ACACT1r"]
["b0331","R_ACACt2pp","b0125","R_ACACT1r","b0331","R_ACACt2pp"]
["b0333","R_ACALD","b0162","R_ACACt2pp","b0333","R_ACALD"]
["b0334","R_ACBIPGT","b0312","R_ACALD","b0334","R_ACBIPGT"]
["b0335","R_ACCOAL","b0314","R_ACBIPGT","b0335","R_ACCOAL"]
["b0338","R_ACGAptspp","b0331","R_ACCOAL","b0338","R_ACGAptspp"]
["b0340","R_ACMANAptspp","b0333","R_ACONMT","b0340","R_ACONMT"]
["b0341","R_ACONMT","b0334","R_ACS","b0341","R_ACS"]
["b0343","R_ACS","b0335","R_ADA","b0343","R_ADA"]
["b0344","R_ADA","b0338","R_ADNCYC","b0344","R_ADNCYC"]
["b0346","R_ADNCYC","b0340","R_ADNt2rpp","b0346","R_ADNt2rpp"]
["b0347","R_ADNt2rpp","b0341","R_ADOCBIK","b0347","R_ADOCBIK"]
["b0348","R_ADOCBIK","b0343","R_ADOCBLS","b0348","R_ADOCBLS"]
["b0349","R_ADOCBLS","b0344","R_AGDC","b0349","R_AGDC"]
["b0350","R_AGDC","b0346","R_ALDD19x","b0350","R_ALDD2y"]
["b0351","R_ALDD2y","b0347","R_ALDD2y","b0351","R_ALDD3y"]
["b0352","R_ALDD3y","b0348","R_ALDD3y","b0352","R_ALLPI"]
["b0365","R_ALLPI","b0349","R_ALLPI","b0365","R_ALLTAMH"]
["b0366","R_ALLTAMH","b0350","R_ALLTAMH","b0366","R_ALTRH"]
["b0367","R_ALTRH","b0351","R_ALTRH","b0367","R_AMALT1"]
["b0368","R_AMALT1","b0352","R_AMALT1","b0368","R_AMALT2"]
["b0399","R_AMALT2","b0365","R_AMALT2","b0399","R_AMALT3"]
["b0400","R_AMALT3","b0366","R_AMALT3","b0400","R_AMALT4"]
["b0401","R_AMALT4","b0367","R_AMALT4","b0401","R_ARAI"]
["b0403","R_ARAI","b0368","R_ARAI","b0403","R_ARBabcpp"]
["b0504","R_ARBabcpp","b0399","R_ARBabcpp","b0504","R_ARGDC"]
["b0506","R_ARGDC","b0400","R_ARBt2rpp","b0506","R_ASNNpp"]
["b0516","R_ASNNpp","b0401","R_ARGDC","b0516","R_ASNS2"]
["b0564","R_ASNS2","b0403","R_ASNNpp","b0564","R_ASPt2_2pp"]
["b0583","R_ASPt2_2pp","b0504","R_ASNS2","b0583","R_AST"]
["b0593","R_AST","b0506","R_ASPT","b0593","R_BETALDHx"]
["b0594","R_BETALDHx","b0516","R_ASPabcpp","b0594","R_BETALDHy"]
["b0595","R_BETALDHy","b0564","R_ASPt2_2pp","b0595","R_BUTCT"]
["b0596","R_BUTCT","b0583","R_AST","b0596","R_BUTt2rpp"]
["b0612","R_BUTt2rpp","b0593","R_BETALDHx","b0612","R_CADVtpp"]
["b0615","R_CADVtpp","b0594","R_BETALDHy","b0615","R_CAT"]
["b0616","R_CAT","b0595","R_BUTCT","b0616","R_CINNDO"]
["b0617","R_CINNDO","b0596","R_BUTt2rpp","b0617","R_CITL"]
["b0619","R_CITL","b0612","R_CADVtpp","b0619","R_CITt7pp"]
["b0620","R_CITt7pp","b0615","R_CAT","b0620","R_CRNDt2rpp"]
["b0677","R_CRNDt2rpp","b0616","R_CINNDO","b0677","R_CRNt2rpp"]
["b0678","R_CRNt2rpp","b0617","R_CITL","b0678","R_CTBTt2rpp"]
["b0679","R_CTBTt2rpp","b0619","R_CITt7pp","b0679","R_CYNTAH"]
["b0694","R_CYNTAH","b0620","R_CRNBTCT","b0694","R_CYNTt2pp"]
["b0695","R_CYNTt2pp","b0652","R_CRNCAR","b0695","R_CYTDt2rpp"]
["b0696","R_CYTDt2rpp","b0654","R_CRNCBCT","b0696","R_DAAD"]
["b0697","R_DAAD","b0655","R_CRNCDH","b0697","R_DADA"]
["b0698","R_DADA","b0677","R_CRNDt2rpp","b0698","R_DDGALK"]
["b0733","R_DDGALK","b0678","R_CRNt2rpp","b0733","R_DHBD"]
["b0734","R_DHBD","b0679","R_CRNt7pp","b0734","R_DHBS"]
["b0864","R_DHBS","b0694","R_CRNt8pp","b0864","R_DHCIND"]
["b0871","R_DHCIND","b0695","R_CTBTt2rpp","b0871","R_DHCINDO"]
["b0894","R_DHCINDO","b0696","R_CYANST","b0894","R_DHPPD"]
["b0895","R_DHPPD","b0697","R_CYNTAH","b0895","R_DMSOR2"]
["b0902","R_DMSOR2","b0698","R_CYNTt2pp","b0902","R_DOGULNR"]
["b0903","R_DOGULNR","b0733","R_CYTD","b0903","R_DRPA"]
["b0904","R_DRPA","b0734","R_CYTDt2rpp","b0904","R_DURIPP"]
["b0972","R_DURIPP","b0864","R_DAAD","b0972","R_DXYLK"]
["b0973","R_DXYLK","b0871","R_DADA","b0973","R_EDD"]
["b0974","R_EDD","b0894","R_DCYTD","b0974","R_ENTCS"]
["b0993","R_ENTCS","b0895","R_DDGALK","b0993","R_FCI"]
["b1101","R_FCI","b0902","R_DHBD","b1101","R_FCLK"]
["b1189","R_FCLK","b0903","R_DHBS","b1189","R_FDH4pp"]
["b1190","R_FDH4pp","b0904","R_DHCIND","b1190","R_FDH5pp"]
["b1197","R_FDH5pp","b0972","R_DHCINDO","b1197","R_FHL"]
["b1223","R_FHL","b0973","R_DHPPD","b1223","R_FORt2pp"]
["b1224","R_FORt2pp","b0974","R_DMQMT","b1224","R_FORtppi"]
["b1225","R_FORtppi","b0993","R_DMSOR2","b1225","R_FRD2"]
["b1226","R_FRD2","b1014","R_DOGULNR","b1226","R_FRD3"]
["b1227","R_FRD3","b1015","R_DRPA","b1227","R_FRUK"]
["b1241","R_FRUK","b1189","R_DURIPP","b1241","R_FRUptspp"]
["b1323","R_FRUpts2pp","b1190","R_DXYLK","b1323","R_FUCtpp"]
["b1474","R_FRUptspp","b1197","R_EDD","b1474","R_FUMt2_2pp"]
["b1475","R_FUCtpp","b1223","R_ENTCS","b1475","R_G3PD5"]
["b1476","R_FUMt2_2pp","b1224","R_F6Pt6_2pp","b1476","R_G3PD6"]
["b1493","R_G3PD6","b1225","R_FCI","b1493","R_G3PD7"]
["b1519","R_G3PD7","b1226","R_FCLK","b1519","R_G6PDA"]
["b1521","R_G6PDA","b1227","R_FDH4pp","b1521","R_GALCTD"]
["b1621","R_GALCTD","b1241","R_FDH5pp","b1621","R_GALCTNt2pp"]
["b1622","R_GALCTNt2pp","b1323","R_FHL","b1622","R_GALS3"]
["b1623","R_GALS3","b1384","R_FORt2pp","b1623","R_GALTptspp"]
["b1646","R_GALTptspp","b1385","R_FORtppi","b1646","R_GALURt2rpp"]
["b1656","R_GALURt2rpp","b1386","R_FRD2","b1656","R_GALabcpp"]
["b1658","R_GALabcpp","b1474","R_FRD3","b1658","R_GLCRAL"]
["b1676","R_GAMptspp","b1475","R_FRUK","b1676","R_GLCabcpp"]
["b1732","R_GLCRAL","b1476","R_FRUURt2rpp","b1732","R_GLCtexi"]
["b1744","R_GLCabcpp","b1493","R_FRUptspp","b1744","R_GLTPD"]
["b1745","R_GLCptspp","b1519","R_FUCtpp","b1745","R_GLUDC"]
["b1746","R_GLCtexi","b1521","R_FUMt2_2pp","b1746","R_GLUNpp"]
["b1747","R_GLTPD","b1524","R_G3PCabcpp","b1747","R_GLUt4pp"]
["b1748","R_GLUDC","b1594","R_G3PD5","b1748","R_GLYAT"]
["b1805","R_GLUNpp","b1621","R_G3PD6","b1805","R_GLYC3Pt6pp"]
["b1814","R_GLUt4pp","b1622","R_G3PD7","b1814","R_GLYCK2"]
["b1817","R_GLYAT","b1623","R_G3PEabcpp","b1827","R_GLYK"]
["b1818","R_GLYCK2","b1646","R_G3PGabcpp","b1851","R_GPDDA1pp"]
["b1819","R_GTHOr","b1656","R_G3PIabcpp","b1896","R_GPDDA2pp"]
["b1827","R_GUI1","b1658","R_G3PSabcpp","b1897","R_GPDDA3pp"]
["b1851","R_GUI2","b1676","R_G6PDA","b1898","R_GPDDA4pp"]
["b1896","R_HEXt2rpp","b1732","R_G6Pt6_2pp","b1899","R_GPDDA5pp"]
["b1897","R_HKNDDH","b1744","R_GALCTD","b1900","R_GTHOr"]
["b1898","R_HKNTDH","b1745","R_GALCTNt2pp","b1901","R_GUI1"]
["b1899","R_HOPNTAL","b1746","R_GALS3","b1987","R_GUI2"]
["b1900","R_HPPPNDO","b1747","R_GALTptspp","b1988","R_HEXt2rpp"]
["b1901","R_HXCT","b1748","R_GALURt2rpp","b1991","R_HKNDDH"]
["b1987","R_HYD1pp","b1805","R_GALabcpp","b1992","R_HKNTDH"]
["b1988","R_HYD2pp","b1814","R_GAM6Pt6_2pp","b1993","R_HOPNTAL"]
["b1991","R_HYD3pp","b1827","R_GLCP","b2091","R_HPPPNDO"]
["b1992","R_ICHORSi","b1851","R_GLCP2","b2092","R_HXCT"]
["b1993","R_ICHORT","b1896","R_GLCRAL","b2093","R_HYD1pp"]
["b2091","R_IDOND","b1897","R_GLCabcpp","b2094","R_HYD2pp"]
["b2092","R_IDOND2","b1898","R_GLCtexi","b2095","R_HYD3pp"]
["b2093","R_IDONt2rpp","b1899","R_GLTPD","b2096","R_ICHORSi"]
["b2094","R_ILEt2rpp","b1900","R_GLUDC","b2097","R_ICHORT"]
["b2095","R_INSt2rpp","b1901","R_GLUNpp","b2148","R_IDOND"]
["b2096","R_Kabcpp","b1987","R_GLUabcpp","b2149","R_IDOND2"]
["b2097","R_LACZ","b1988","R_GLUt4pp","b2150","R_IDONt2rpp"]
["b2148","R_LCARS","b1991","R_GLYAT","b2167","R_ILEt2rpp"]
["b2149","R_LCTStpp","b1992","R_GLYC3Pabcpp","b2168","R_INSt2rpp"]
["b2150","R_LEUt2rpp","b1993","R_GLYC3Pt6pp","b2169","R_Kabcpp"]
["b2167","R_LYXI","b2091","R_GLYCK2","b2219","R_LACZ"]
["b2168","R_LYXt2pp","b2092","R_GLYK","b2220","R_LCARS"]
["b2169","R_L_LACD2","b2093","R_GPDDA1pp","b2221","R_LCTStpp"]
["b2219","R_L_LACD3","b2094","R_GPDDA2pp","b2222","R_LEUt2rpp"]
["b2220","R_M1PD","b2095","R_GPDDA3pp","b2223","R_LYXI"]
["b2221","R_MALDt2_2pp","b2096","R_GPDDA4pp","b2224","R_LYXt2pp"]
["b2222","R_MALTHXabcpp","b2097","R_GPDDA5pp","b2239","R_L_LACD2"]
["b2223","R_MALTHXtexi","b2143","R_GTHOr","b2240","R_L_LACD3"]
["b2224","R_MALTPTabcpp","b2148","R_GUI1","b2241","R_M1PD"]
["b2241","R_MALTPTtexi","b2149","R_GUI2","b2242","R_MALDt2_2pp"]
["b2242","R_MALTTRabcpp","b2150","R_HEXt2rpp","b2243","R_MALTHXabcpp"]
["b2243","R_MALTTRtexi","b2167","R_HKNDDH","b2296","R_MALTHXtexi"]
["b2296","R_MALTTTRabcpp","b2168","R_HKNTDH","b2364","R_MALTPTabcpp"]
["b2364","R_MALTTTRtexi","b2169","R_HOPNTAL","b2366","R_MALTPTtexi"]
["b2366","R_MALTabcpp","b2219","R_HPPPNDO","b2405","R_MALTTRabcpp"]
["b2405","R_MALTptspp","b2220","R_HXCT","b2406","R_MALTTRtexi"]
["b2406","R_MALTtexi","b2221","R_HYD1pp","b2407","R_MALTTTRabcpp"]
["b2407","R_MALt2_2pp","b2222","R_HYD2pp","b2492","R_MALTTTRtexi"]
["b2492","R_MANAO","b2223","R_HYD3pp","b2537","R_MALTabcpp"]
["b2537","R_MANptspp","b2224","R_ICHORSi","b2538","R_MALTptspp"]
["b2538","R_MCITD","b2232","R_ICHORT","b2539","R_MALTtexi"]
["b2539","R_MCITL2","b2239","R_IDOND","b2540","R_MALt2_2pp"]
["b2540","R_MCITS","b2240","R_IDOND2","b2541","R_MANAO"]
["b2541","R_MELIBt2pp","b2241","R_IDONt2rpp","b2542","R_MCITD"]
["b2542","R_MLTG1","b2242","R_ILEt2rpp","b2573","R_MCITL2"]
["b2573","R_MLTG2","b2243","R_INSt2rpp","b2707","R_MCITS"]
["b2702","R_MLTG3","b2296","R_Kabcpp","b2719","R_MELIBt2pp"]
["b2703","R_MLTG4","b2364","R_LACZ","b2720","R_MLTG1"]
["b2704","R_MLTG5","b2366","R_LCARS","b2721","R_MLTG2"]
["b2705","R_MLTP1","b2405","R_LCTStpp","b2722","R_MLTG3"]
["b2707","R_MLTP2","b2406","R_LEUt2rpp","b2723","R_MLTG4"]
["b2719","R_MLTP3","b2407","R_LYXI","b2724","R_MLTG5"]
["b2720","R_MNLptspp","b2492","R_LYXt2pp","b2731","R_MLTP1"]
["b2721","R_NNDMBRT","b2537","R_L_LACD2","b2741","R_MLTP2"]
["b2722","R_NO2t2rpp","b2538","R_L_LACD3","b2787","R_MLTP3"]
["b2723","R_NTRIR2x","b2539","R_M1PD","b2799","R_MNLptspp"]
["b2724","R_OBTFL","b2540","R_MALDt2_2pp","b2800","R_NNDMBRT"]
["b2731","R_OP4ENH","b2541","R_MALTHXabcpp","b2801","R_NO2t2rpp"]
["b2741","R_OROTt2_2pp","b2542","R_MALTHXtexi","b2802","R_NTRIR2x"]
["b2787","R_PFK_2","b2573","R_MALTPTabcpp","b2803","R_OBTFL"]
["b2799","R_PFL","b2702","R_MALTPTtexi","b2805","R_OP4ENH"]
["b2800","R_PIuabcpp","b2703","R_MALTTRabcpp","b2808","R_OROTt2_2pp"]
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