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["Enter information starting on row 6",{"$nulls":6},"Use the next sheet for studies of new issues where cost consists only of fixed costs plus a per-subject cost"]
["for every sample size you are considering"]
[null,null,"Min","Min"]
["Total","Total Study Cost",{"v":999999,"d":"999,999"},{"v":999999,"d":"999,999"},{"$nulls":3},"Sample size choices given below are defensible in terms of cost efficiency, the scientific value produced per dollar spent."]
["Sample Size","with this Sample Size","cost/N","cost/root N","Is Nmin?","Is Nroot",null,"Nmin is guaranteed to be more cost efficient than any larger sample size that you have entered in columns A and B."]
[null,null,{"v":999999,"d":"999,999"},{"v":999999,"d":"999,999"},0,0,null,"Nroot has this guarantee if your study concerns a new issue, where very little is already known."]
[null,null,{"v":999999,"d":"999,999"},{"v":999999,"d":"999,999"},0,0,null,"See reference for more details."]
[null,null,{"v":999999,"d":"999,999"},{"v":999999,"d":"999,999"},0,0,null,null,"Reference: ","Bacchetti P, McCulloch CE, Segal MR. Simple, defensible sample sizes based on cost efficiency"]
[null,null,{"v":999999,"d":"999,999"},{"v":999999,"d":"999,999"},0,0,{"$nulls":3},"(with Discussion and Rejoinder).  Biometrics, 64: 577–594, 2008."]
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