Supplementary material for the manuscript "Polymorphic toxin systems: comprehensive characterization of trafficking modes, processing, mechanisms, immunity and ecology using comparative genomics"

Polymorphic toxin systems: comprehensive characterization of trafficking modes, processing, mechanisms, immunity and ecology using comparative genomics

Dapeng Zhang¹, Robson F. de Souza^1,2, Vivek Anantharaman¹, Lakshminarayan M. Iyer¹ and L. Aravind^1,*,
^* Address for correspondence: L. Aravind (aravind@mail.nih.gov)

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
²Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil

Abstract

Paste abstract here

Multiple sequence alignments

Toxin Classification

Hierarchical classification of toxin domains based on their molecular functions

Database-related files

Comprehensive list of gene neighborhoods associated with polymorphic toxins
Tables
- Functional classification of all domains present in toxin and toxin-related proteins
- Compact representation of gene neighborhoods
- Compact representation of polyimmunity loci
- Comprehensive tabular representation of gene neighborhoods for toxin and immunity proteins This is the data used to generate the barplots in Figure 14
- Gene neighborhood network for toxin and immunity proteins [Cytoscape file] [PDF]
- Domain architecture for all proteins analysed in this study
- Diverse domain architectures of Amoebophilus asiaticus proteins containing the APD1 and APD2-like prodomains
- Secretory system assignments for toxins
- Life style and protein abundance per taxa: number of toxins, active toxins and immunity proteins and life style information as seen in figure 13
Sequences
- All toxins
- All immunity proteins
Protein identifiers (GI numbers)
- List of all toxins (NCBI GI numbers)
- List of active toxins: active toxins are toxins with N-terminal secretory system markers or that are encoded downstream to genes containing such markers
- List of all immunity proteins
Sequence analysis details