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["ID","Year of publication ","Title","Journal","Impact factor","Publication language (1=English; 2=Chinese)","Collaboration research of different countries(1=Yes;2=No)","Region in which trials were conducted (1=North America;2=Europe;3=international;4=other)","Funding source(1=Yes; 2=No) ","Choice of comparator interventions(1=placebo;2= sole intervention; 3=metformin plus other therapies;4=above combinations)","comparator Intervention","“Randomized” in the title or abstract","Background","Trial design","Participants","Interventions","Primary outcome and secndary outcome","Sample size","Randomization","description of alocation concealment","Whether the sequence was concealed until the intervention were assigned","Participant blinding","Treatment provider blinding","Outcome assessor blinding","Statistical methods","Flow chart","Recruitment","Baseline data","Intent-to-treat\nanalysis","Outcomes and estimation","Ancillary analyses","Harms"]
[1,2004,"A randomized, 48-week, placebo-controlled trial of intensive lifestyle modiﬁcation and/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study","FERTILITY AND STERILITY",3.564,1,2,1,1,4,"lifestyle modiﬁcation+MET;  lifestyle modiﬁcation+Placebo;Placebo  ",1,1,1,1,1,0,0,1,1,1,1,1,1,1,1,1,1,0,1,1,1]
[2,2010,"An assessment of lifestyle modiﬁcation versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate–metformin in patients with polycystic ovary syndrome","Fertility and Sterility",3.564,1,2,4,2,4,"clomiphene;\nclomiphene+Met; lifestyle modiﬁcation",1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0]
[3,2007,"Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome","The New England Journal of Medicine",53.295,1,1,1,1,4,"cc or cc+MET",1,1,1,1,1,1,1,1,0,0,1,1,1,1,1,1,1,1,1,1,1]
[4,2002,"Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial","Human Reproduction",4.475,1,2,2,2,2,"placebo",1,1,1,1,1,0,0,1,0,0,1,1,0,1,0,0,1,0,0,0,0]
[5,2009,"Comparison of clomiphene citrate, metformin, or the combination of both for ﬁrst-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial","Fertility and Sterility",3.564,1,1,4,2,4,"CC;Met+CC",1,1,1,1,1,1,1,1,1,1,1,1,0,1,1,1,1,1,1,0,0]
[6,1996,"DECREASES IN OVARIAN CYTOCHROME P450c17a ACTIVITY AND SERUM FREE TESTOSTERONE AFTER REDUCTION OF INSULIN SECRETION IN POLYCYSTIC OVARY SYNDROME","The New England Journal of Medicine",53.298,1,2,4,1,1,"placebo",0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,0,0,0,0]
[7,2008,"Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?","Human Reproduction",4.475,1,2,2,2,2,"CC+palcebo",1,1,1,1,0,0,0,1,1,1,1,1,0,1,0,1,1,0,1,1,0]
[8,2006,"Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial","BMJ",14.093,1,2,2,1,2,"CC+palcebo",1,1,1,1,1,1,1,1,1,1,1,1,0,1,1,1,1,0,1,0,0]
[9,2000,"Effect of Long-Term Treatment with Metformin Added to Hypocaloric Diet on Body Composition, Fat Distribution, and Androgen and Insulin Levels in Abdominally Obese Women with and without the Polycystic Ovary Syndrome","The Journal of Clinical Endocrinology & Metabolism",5.967,1,1,2,2,1,"palcebo",1,1,1,1,1,0,0,1,1,1,1,1,0,1,0,0,1,0,0,1,0]
[10,2001,"Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial.","Human Reproduction",4.475,1,2,4,1,1,"palcebo",1,1,1,1,1,1,1,1,1,1,1,1,1,1,0,1,1,1,1,1,0]
[11,1998,"EFFECTS OF METFORMIN ON SPONTANEOUS AND CLOMIPHENE-INDUCED OVULATION IN THE POLYCYSTIC OVARY SYNDROME","The New England Journal of Medicine",53.298,1,1,1,1,1,"palcebo",0,1,0,0,1,0,0,0,0,0,0,0,0,1,0,0,1,0,0,1,0]
[12,2009,"Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients","J Assist Reprod Genet",1.844,1,2,4,2,3,"cc",1,1,1,1,1,1,0,1,1,1,0,0,0,0,1,1,1,1,1,1,0]
[13,2001,"Insulin Reduction with Metformin Increases Luteal Phase Serum Glycodelin and Insulin-Like Growth Factor-Binding Protein 1 Concentrations and Enhances Uterine Vascularity and Blood Flow in the Polycystic Ovary Syndrome","The Journal of Clinical Endocrinology & Metabolism",5.967,1,1,4,1,1,"palcebo",0,1,0,1,1,0,0,0,0,0,1,1,0,1,0,0,1,0,0,0,0]
[14,2002,"Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice","Br J Clin Pharmacol.",2.958,1,2,2,2,3,"MET+CC",1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,1,0,1,0,0]
[15,2000,"Metformin Effects on Clinical Features, Endocrine and Metabolic Profiles, and Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled 6-Month Trial, followed by Open, Long-Term Clinical Evaluation*","The Journal of Clinical Endocrinology & Metabolism",5.967,1,2,2,1,1,"palcebo",1,1,1,1,1,1,0,1,0,0,0,0,0,1,0,0,1,0,1,0,0]
[16,2001,"Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in\npatients with polycystic ovary syndrome who are resistant to clomiphene citrate alone","Fertility and Sterility",3.564,1,2,1,1,2,"cc+placebo",1,1,1,1,1,0,0,1,0,0,0,0,0,1,0,0,1,1,0,0,0]
[17,2002,"Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate–resistant women with polycystic ovary syndrome","Fertility and Sterility",3.564,1,2,2,2,1,"palcebo",1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0]
[18,2002,"Ovarian Function and Metabolic Factors in Women with Oligomenorrhea Treated with Metformin in a Randomized Double Blind Placebo-Controlled Trial","The Journal of Clinical Endocrinology & Metabolism",5.967,1,2,2,2,1,"palcebo",1,1,1,1,1,0,1,1,1,1,1,1,0,1,1,0,1,1,1,0,1]
[19,2010,"PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene","Human Reproduction",4.475,1,2,4,1,4,"palcebo;CC+met;cc",1,1,1,1,1,1,1,0,0,0,1,1,0,1,1,0,1,1,0,1,1]
[20,2005,"Prospective Parallel Randomized, Double-Blind, Double-Dummy Controlled Clinical Trial Comparing Clomiphene Citrate and Metformin as the First-Line Treatment for Ovulation Induction in Nonobese Anovulatory Women with Polycystic Ovary Syndrome","The Journal of Clinical Endocrinology & Metabolism",5.967,1,2,2,2,4,"placebo;placebo+CC",1,1,1,1,1,1,1,1,1,1,1,1,0,1,1,1,1,1,0,0,1]
[21,2009,"Short-term metformin treatment for clomiphene citrate–resistant women with polycystic ovary syndrome","International Journal of Gynecology and Obstetrics",2.045,1,1,4,2,1,"placebo",1,1,1,1,1,0,1,1,1,1,1,1,0,0,1,1,1,0,0,0,0]
[22,2006,"The effect of metformin on fat distribution and the metabolic syndrome inwomenwith polycystic ovary syndrome—a randomised, double-blind,placebo-controlled trial","bjog-an international journal of obstetrics and gynaecology",3.407,1,2,2,2,1,"Placebo",1,1,1,1,0,1,1,1,0,0,1,1,0,1,1,0,1,1,0,1,0]
[23,2004,"The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome","European Journal of Obstetrics & Gynecology and Reproductive Biology",1.974,1,2,2,2,2,"CC",1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0]
[24,2006,"Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic proﬁles in women with polycystic ovary syndrome","Fertility and Sterility",3.564,1,2,1,2,2,"CC",1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0]
[25,2005,"Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome","nternational Journal of Gynecology and Obstetrics",2.045,1,2,4,2,2,"CC",1,1,1,1,1,1,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0]
[26,2011,"Do women with ovaries of polycystic morphology without any other features of PCOS beneﬁt from short-term metformin co-treatment during IVF? A double-blind, placebo-controlled, randomized trial","Human Reproduction",4.475,1,2,2,1,1,"placebo",1,1,1,1,1,1,1,1,1,1,1,1,0,1,1,1,1,1,1,1,1]
[27,2012,"Effect of Metformin and Pioglitazone Treatment on Cardiovascular Risk Profile in Polycystic Ovary Syndrome","Acta Med Indones","NA",1,2,4,2,2," pioglitozone",1,1,1,1,1,0,0,1,0,0,0,0,0,1,1,1,1,0,0,1,1]
[28,2011,"Effects of Simvastatin and Metformin on Polycystic Ovary Syndrome after Six Months of Treatment","J Clin Endocrinol Metab",5.967,1,1,2,1,4,"simvastatin; simvastatin+MET",1,1,0,1,1,1,0,1,1,1,0,0,0,1,1,1,1,0,1,1,1]
[29,2012,"Metformin Improves Pregnancy and Live-Birth Rates in Women with Polycystic Ovary Syndrome (PCOS): A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial","J Clin Endocrinol Metab",5.967,1,2,2,1,1,"placebo",1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]
[30,2012,"Metformin versus lifestyle changes in treating women with polycystic ovary syndrome","Gynecological Endocrinology",1.581,1,2,4,2,2,"lifestyle changes treatment",1,0,1,0,1,0,1,0,0,0,0,0,0,1,1,0,1,0,0,0,0]
[31,2011,"Metformin versus metformin plus rosiglitazone in women with polycystic ovary syndrome","Chin Med J ",0.864,1,2,4,2,3,"metformin plus rosiglitazone ",1,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0]
[32,2010,"Metformin Versus Placebo from First Trimester to Delivery in Polycystic Ovary Syndrome: A\nRandomized, Controlled Multicenter Study","J Clin Endocrinol Metab",5.967,1,2,4,2,1,"placebo",1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,0,1,1,1,1,1]
[33,2010,"Metformin Versus Placebo from First Trimester to Delivery in Polycystic Ovary Syndrome: A Randomized, Controlled Multicenter Study","J Clin Endocrinol Metab",5.967,1,2,4,1,1,"placebo",1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,0,1,1,1,1,1]
[34,2012,"Metformin's Effect on First-Year Weight Gain: A Follow-up Study ","Pediatrics",5.437,1,2,2,1,1,"palcebo",1,1,1,1,1,0,0,1,1,0,0,0,0,1,0,0,1,1,1,0,1]
[35,null,"Pretreatment and co-administration of oral anti-diabetic agent with clomiphene citrate or rFSH for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome","The Journal of Obstetrics and Gynaecology Research",0.942,1,2,4,2,4,"MET+rFSH; rFSH",1,1,1,1,1,1,0,0,0,0,0,0,0,1,0,1,1,0,0,0,1]
[36,2011,"Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome","The Journal of Obstetrics and Gynaecology Research",0.942,1,2,4,1,2,"1000 mg and 1700 mg/day of metformin",1,1,1,1,1,0,0,1,1,1,0,0,0,0,1,1,1,1,1,1,1]
[37,2011,"The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study"," Assist Reprod Genet",1.844,1,2,4,1,2,"orlistat ",1,1,1,1,1,1,1,1,0,0,0,0,0,1,0,1,1,0,0,0,0]
[38,2011,"The Effects of Metformin with Lifestyle Therapy in Polycystic Ovary Syndrome: A Randomized Double Blind Study","Fertil Steril",3.564,1,2,1,1,4,"placebo + lifestyle",1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]
[39,2011,"Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study","Human Reproduction",4.475,1,1,2,1,1,"placebo",1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]