{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Sheet0"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet0","index":0,"n_rows":225,"n_cols":4,"rows_kept":225,"flags":["formulas_cached_only"]}
["© 2000-2011 Ingenuity Systems, Inc. All rights reserved.","Color indicates significant p-value"]
["Ingenuity Canonical Pathways"," -log(p-value)","Ratio","Molecules"]
["Oxidative Phosphorylation",{"v":4.16,"d":"4.16E+00"},{"v":0.0699,"d":"6.99E-02"},"ATP6V0E2,NDUFC1,COX6B1,NDUFS8,COX10,COX5A,NDUFS6,NDUFA12,COX7A1,ATP5G3"]
["Mitochondrial Dysfunction",{"v":4.06,"d":"4.06E+00"},{"v":0.0735,"d":"7.35E-02"},"COX6B1,NDUFS8,COX10,CPT1B,COX5A,TRAK1,NDUFS6,NDUFA12,MAPK12,COX7A1"]
["Breast Cancer Regulation by Stathmin1",{"v":3.81,"d":"3.81E+00"},{"v":0.06,"d":"6.00E-02"},"PPP1R14C,PIK3C2B,E2F6,ADCY2,PRKCQ,CAMK2A,TUBA8,PPM1L,PPP2R5B,TUBA4A,PPP1R3A,TUBA3C/TUBA3D"]
["ERK/MAPK Signaling",{"v":2.81,"d":"2.81E+00"},{"v":0.0505,"d":"5.05E-02"},"PLA2G4E,PPP1R14C,PIK3C2B,TLN2,PLA2G12A,HSPB2,PPM1L,PPP2R5B,PLCG1,PPP1R3A"]
["Cardiac β-adrenergic Signaling",{"v":2.56,"d":"2.56E+00"},{"v":0.0576,"d":"5.76E-02"},"PPP1R14C,ADCY2,PPM1L,PPP2R5B,PDE4A,AKAP6,PPP1R3A,PDE4D"]
["Glycolysis/Gluconeogenesis",{"v":2.47,"d":"2.47E+00"},{"v":0.0667,"d":"6.67E-02"},"PGK1,PGM1,ALDOA,TPI1,Gapdh (includes others),LDHB"]
["Inositol Metabolism",{"v":2.46,"d":"2.46E+00"},{"v":0.333,"d":"3.33E-01"},"ALDOA,TPI1"]
["Ubiquinone Biosynthesis",{"v":2.46,"d":"2.46E+00"},{"v":0.0725,"d":"7.25E-02"},"NDUFC1,NDUFS8,UFSP1,NDUFS6,NDUFA12"]
["14-3-3-mediated Signaling",{"v":2.44,"d":"2.44E+00"},{"v":0.0593,"d":"5.93E-02"},"PIK3C2B,PRKCQ,TUBA8,TUBA4A,PLCG1,TUBA3C/TUBA3D,MAPK12"]
["Aldosterone Signaling in Epithelial Cells",{"v":2.16,"d":"2.16E+00"},{"v":0.0506,"d":"5.06E-02"},"PIK3C2B,SACS,PRKCQ,HSPA1L,DNAJC27,HSPB2,PLCG1,DNAJB5"]
["Production of Nitric Oxide and Reactive Oxygen Species in Macrophages",{"v":2.14,"d":"2.14E+00"},{"v":0.0494,"d":"4.94E-02"},"PPP1R14C,PIK3C2B,PRKCQ,PPM1L,PPP2R5B,PLCG1,PPP1R3A,MAPK12"]
["Fc Epsilon RI Signaling",{"v":2.03,"d":"2.03E+00"},{"v":0.0571,"d":"5.71E-02"},"PLA2G4E,PIK3C2B,PRKCQ,PLA2G12A,PLCG1,MAPK12"]
["Endothelin-1 Signaling",{"v":2.03,"d":"2.03E+00"},{"v":0.0476,"d":"4.76E-02"},"PLA2G4E,PIK3C2B,ADCY2,PRKCQ,PLA2G12A,GNAO1,PLCG1,MAPK12"]
["Dopamine Receptor Signaling",{"v":1.96,"d":"1.96E+00"},{"v":0.0649,"d":"6.49E-02"},"PPP1R14C,ADCY2,PPM1L,PPP2R5B,PPP1R3A"]
["CCR3 Signaling in Eosinophils",{"v":1.83,"d":"1.83E+00"},{"v":0.05,"d":"5.00E-02"},"PLA2G4E,PIK3C2B,PRKCQ,PLA2G12A,CFL2,MAPK12"]
["Type II Diabetes Mellitus Signaling",{"v":1.81,"d":"1.81E+00"},{"v":0.0455,"d":"4.55E-02"},"PIK3C2B,PRKCQ,PRKAB2,MAPK12,ADIPOR1,KCNJ11"]
["Thrombopoietin Signaling",{"v":1.75,"d":"1.75E+00"},{"v":0.0678,"d":"6.78E-02"},"PIK3C2B,THPO,PRKCQ,PLCG1"]
["CTLA4 Signaling in Cytotoxic T Lymphocytes",{"v":1.73,"d":"1.73E+00"},{"v":0.0515,"d":"5.15E-02"},"PIK3C2B,AP1S2,PPM1L,PPP2R5B,PLCG1"]
["CDK5 Signaling",{"v":1.71,"d":"1.71E+00"},{"v":0.0562,"d":"5.62E-02"},"PPP1R14C,ADCY2,PPM1L,PPP2R5B,PPP1R3A"]
["TR/RXR Activation",{"v":1.69,"d":"1.69E+00"},{"v":0.0562,"d":"5.62E-02"},"PIK3C2B,RXRG,SLC16A3,UCP1,PPARGC1A"]
["Protein Kinase A Signaling",{"v":1.68,"d":"1.68E+00"},{"v":0.0348,"d":"3.48E-02"},"PPP1R14C,ADCY2,PRKCQ,CAMK2A,HIST1H1A,PDE4A,PLCG1,AKAP6,PPP1R3A,TTN,PDE4D"]
["Synaptic Long Term Depression",{"v":1.65,"d":"1.65E+00"},{"v":0.0441,"d":"4.41E-02"},"PLA2G4E,PRKCQ,PLA2G12A,PPM1L,GNAO1,PPP2R5B"]
["Role of MAPK Signaling in the Pathogenesis of Influenza",{"v":1.62,"d":"1.62E+00"},{"v":0.0635,"d":"6.35E-02"},"PLA2G4E,PLA2G12A,MAPK12,RABGEF1"]
["Cellular Effects of Sildenafil (Viagra)",{"v":1.61,"d":"1.61E+00"},{"v":0.0522,"d":"5.22E-02"},"KCNN1,ADCY2,PABPC4,PDE4A,PLCG1,PDE4D,MYH1"]
["Cell Cycle Regulation by BTG Family Proteins",{"v":1.58,"d":"1.58E+00"},{"v":0.0833,"d":"8.33E-02"},"E2F6,PPM1L,PPP2R5B"]
["MIF Regulation of Innate Immunity",{"v":1.52,"d":"1.52E+00"},{"v":0.0667,"d":"6.67E-02"},"PLA2G4E,PLA2G12A,MAPK12"]
["Glioma Signaling",{"v":1.52,"d":"1.52E+00"},{"v":0.0467,"d":"4.67E-02"},"PIK3C2B,E2F6,PRKCQ,CAMK2A,PLCG1"]
["Phenylalanine, Tyrosine and Tryptophan Biosynthesis",{"v":1.5,"d":"1.50E+00"},{"v":0.118,"d":"1.18E-01"},"GOT1,GOT2"]
["AMPK Signaling",{"v":1.48,"d":"1.48E+00"},{"v":0.0417,"d":"4.17E-02"},"PIK3C2B,PRKAB2,CPT1B,PPM1L,PPP2R5B,MAPK12"]
["Neuropathic Pain Signaling In Dorsal Horn Neurons",{"v":1.48,"d":"1.48E+00"},{"v":0.0485,"d":"4.85E-02"},"PIK3C2B,KCNN1,PRKCQ,CAMK2A,PLCG1"]
["Melatonin Signaling",{"v":1.46,"d":"1.46E+00"},{"v":0.0571,"d":"5.71E-02"},"PRKCQ,CAMK2A,GNAO1,PLCG1"]
["Macropinocytosis Signaling",{"v":1.44,"d":"1.44E+00"},{"v":0.0526,"d":"5.26E-02"},"PIK3C2B,PRKCQ,PLCG1,ITGB6"]
["Cysteine Metabolism",{"v":1.43,"d":"1.43E+00"},{"v":0.06,"d":"6.00E-02"},"GOT1,GOT2,LDHB"]
["ILK Signaling",{"v":1.4,"d":"1.40E+00"},{"v":0.037,"d":"3.70E-02"},"PIK3C2B,CFL2,PPM1L,PPP2R5B,MAPK12,ITGB6,MYH1"]
["Protein Ubiquitination Pathway",{"v":1.38,"d":"1.38E+00"},{"v":0.0333,"d":"3.33E-02"},"SACS,USP15,HSPA1L,USP13,UBE2B,DNAJC27,HSPB2,USP2,DNAJB5"]
["Corticotropin Releasing Hormone Signaling",{"v":1.32,"d":"1.32E+00"},{"v":0.041,"d":"4.10E-02"},"ADCY2,PRKCQ,GNAO1,PLCG1,MAPK12"]
["HER-2 Signaling in Breast Cancer",{"v":1.3,"d":"1.30E+00"},{"v":0.0494,"d":"4.94E-02"},"PIK3C2B,PRKCQ,PLCG1,ITGB6"]
["Renin-Angiotensin Signaling",{"v":1.29,"d":"1.29E+00"},{"v":0.0439,"d":"4.39E-02"},"PIK3C2B,ADCY2,PRKCQ,PLCG1,MAPK12"]
["Thrombin Signaling",{"v":1.25,"d":"1.25E+00"},{"v":0.0352,"d":"3.52E-02"},"PIK3C2B,ADCY2,PRKCQ,CAMK2A,GNAO1,PLCG1,MAPK12"]
["Glycerophospholipid Metabolism",{"v":1.25,"d":"1.25E+00"},{"v":0.041,"d":"4.10E-02"},"PLA2G4E,PLA2G12A,PLCG1,ACHE,GOT1"]
["Purine Metabolism",{"v":1.25,"d":"1.25E+00"},{"v":0.0328,"d":"3.28E-02"},"ADCY2,ADAL,KIF1B,PDE4A,GMPR,IDE,PDE4D,ATP5G3,MYH1"]
["P2Y Purigenic Receptor Signaling Pathway",{"v":1.2,"d":"1.20E+00"},{"v":0.04,"d":"4.00E-02"},"P2RY2,PIK3C2B,ADCY2,PRKCQ,PLCG1"]
["p70S6K Signaling",{"v":1.17,"d":"1.17E+00"},{"v":0.0403,"d":"4.03E-02"},"PIK3C2B,PRKCQ,PPM1L,PPP2R5B,PLCG1"]
["FGF Signaling",{"v":1.17,"d":"1.17E+00"},{"v":0.0465,"d":"4.65E-02"},"PIK3C2B,PLCG1,MAPK12,FGF13"]
["Melanocyte Development and Pigmentation Signaling",{"v":1.15,"d":"1.15E+00"},{"v":0.0455,"d":"4.55E-02"},"PIK3C2B,ADCY2,PLCG1,DCT"]
["G Beta Gamma Signaling",{"v":1.12,"d":"1.12E+00"},{"v":0.0388,"d":"3.88E-02"},"ADCY2,PRKCQ,GNAO1,PLCG1"]
["Virus Entry via Endocytic Pathways",{"v":1.11,"d":"1.11E+00"},{"v":0.043,"d":"4.30E-02"},"PIK3C2B,PRKCQ,PLCG1,ITGB6"]
["Xenobiotic Metabolism Signaling",{"v":1.1,"d":"1.10E+00"},{"v":0.0269,"d":"2.69E-02"},"GSTA3,PIK3C2B,PRKCQ,CAMK2A,PPM1L,PPP2R5B,MAPK12,PPARGC1A"]
["PPARα/RXRα Activation",{"v":1.1,"d":"1.10E+00"},{"v":0.0337,"d":"3.37E-02"},"ADCY2,PRKAB2,PLCG1,GOT2,ADIPOR1,PPARGC1A"]
["p53 Signaling",{"v":1.09,"d":"1.09E+00"},{"v":0.0421,"d":"4.21E-02"},"CCNG1,PIK3C2B,ADCK3,C12orf5"]
["IL-1 Signaling",{"v":1.07,"d":"1.07E+00"},{"v":0.0396,"d":"3.96E-02"},"ECSIT,ADCY2,GNAO1,MAPK12"]
["Starch and Sucrose Metabolism",{"v":1.07,"d":"1.07E+00"},{"v":0.0429,"d":"4.29E-02"},"UGP2,PGM1,AGL"]
["CREB Signaling in Neurons",{"v":1.06,"d":"1.06E+00"},{"v":0.0316,"d":"3.16E-02"},"PIK3C2B,ADCY2,PRKCQ,CAMK2A,GNAO1,PLCG1"]
["Wnt/β-catenin Signaling",{"v":1.05,"d":"1.05E+00"},{"v":0.0347,"d":"3.47E-02"},"FRZB,SOX6,PPM1L,GNAO1,PPP2R5B,FZD9"]
["Relaxin Signaling",{"v":1.02,"d":"1.02E+00"},{"v":0.0345,"d":"3.45E-02"},"PIK3C2B,ADCY2,GNAO1,PDE4A,PDE4D"]
["Tyrosine Metabolism",{"v":1.01,"d":"1.01E+00"},{"v":0.0411,"d":"4.11E-02"},"GOT1,DCT,GOT2"]
["MIF-mediated Glucocorticoid Regulation",{"v":1.01,"d":"1.01E+00"},{"v":0.0541,"d":"5.41E-02"},"PLA2G4E,PLA2G12A"]
["Role of NFAT in Cardiac Hypertrophy",{"v":0.999,"d":"9.99E-01"},{"v":0.0306,"d":"3.06E-02"},"PIK3C2B,ADCY2,PRKCQ,CAMK2A,PLCG1,MAPK12"]
["Aryl Hydrocarbon Receptor Signaling",{"v":0.995,"d":"9.95E-01"},{"v":0.0345,"d":"3.45E-02"},"GSTA3,RXRG,NFIC,HSPB2,DCT"]
["CCR5 Signaling in Macrophages",{"v":0.995,"d":"9.95E-01"},{"v":0.0353,"d":"3.53E-02"},"PRKCQ,PLCG1,MAPK12"]
["Citrate Cycle",{"v":0.983,"d":"9.83E-01"},{"v":0.069,"d":"6.90E-02"},"IDH2,IDH3B"]
["IL-15 Signaling",{"v":0.979,"d":"9.79E-01"},{"v":0.0462,"d":"4.62E-02"},"PIK3C2B,PLCG1,MAPK12"]
["iCOS-iCOSL Signaling in T Helper Cells",{"v":0.974,"d":"9.74E-01"},{"v":0.0348,"d":"3.48E-02"},"PIK3C2B,PRKCQ,CAMK2A,PLCG1"]
["HGF Signaling",{"v":0.974,"d":"9.74E-01"},{"v":0.0392,"d":"3.92E-02"},"PIK3C2B,PRKCQ,PLCG1,MAPK12"]
["p38 MAPK Signaling",{"v":0.961,"d":"9.61E-01"},{"v":0.0377,"d":"3.77E-02"},"PLA2G4E,PLA2G12A,HSPB2,MAPK12"]
["Pentose Phosphate Pathway",{"v":0.958,"d":"9.58E-01"},{"v":0.0938,"d":"9.38E-02"},"G6pd2,PGM1,ALDOA"]
["Non-Small Cell Lung Cancer Signaling",{"v":0.931,"d":"9.31E-01"},{"v":0.0411,"d":"4.11E-02"},"PIK3C2B,RXRG,PLCG1"]
["Synaptic Long Term Potentiation",{"v":0.902,"d":"9.02E-01"},{"v":0.0381,"d":"3.81E-02"},"PPP1R14C,PRKCQ,CAMK2A,PPP1R3A"]
["Agrin Interactions at Neuromuscular Junction",{"v":0.902,"d":"9.02E-01"},{"v":0.0441,"d":"4.41E-02"},"CHRNA1,RAPSN,MAPK12"]
["Growth Hormone Signaling",{"v":0.902,"d":"9.02E-01"},{"v":0.0423,"d":"4.23E-02"},"PIK3C2B,PRKCQ,PLCG1"]
["Erythropoietin Signaling",{"v":0.887,"d":"8.87E-01"},{"v":0.0405,"d":"4.05E-02"},"PIK3C2B,PRKCQ,PLCG1"]
["Chemokine Signaling",{"v":0.873,"d":"8.73E-01"},{"v":0.0435,"d":"4.35E-02"},"CAMK2A,PLCG1,MAPK12"]
["PKCθ Signaling in T Lymphocytes",{"v":0.869,"d":"8.69E-01"},{"v":0.0301,"d":"3.01E-02"},"PIK3C2B,PRKCQ,CAMK2A,PLCG1"]
["Germ Cell-Sertoli Cell Junction Signaling",{"v":0.868,"d":"8.68E-01"},{"v":0.0311,"d":"3.11E-02"},"PIK3C2B,TUBA8,TUBA4A,TUBA3C/TUBA3D,MAPK12"]
["CD28 Signaling in T Helper Cells",{"v":0.858,"d":"8.58E-01"},{"v":0.032,"d":"3.20E-02"},"PIK3C2B,PRKCQ,PLCG1,MAPK12"]
["CXCR4 Signaling",{"v":0.85,"d":"8.50E-01"},{"v":0.0312,"d":"3.12E-02"},"PIK3C2B,ADCY2,PRKCQ,GNAO1,MAPK12"]
["Glutamate Metabolism",{"v":0.848,"d":"8.48E-01"},{"v":0.0556,"d":"5.56E-02"},"GOT1,GOT2"]
["LPS-stimulated MAPK Signaling",{"v":0.846,"d":"8.46E-01"},{"v":0.038,"d":"3.80E-02"},"PIK3C2B,PRKCQ,MAPK12"]
["Phospholipid Degradation",{"v":0.832,"d":"8.32E-01"},{"v":0.037,"d":"3.70E-02"},"PLA2G4E,PLA2G12A,PLCG1"]
["Alanine and Aspartate Metabolism",{"v":0.828,"d":"8.28E-01"},{"v":0.0513,"d":"5.13E-02"},"GOT1,GOT2"]
["Phenylalanine Metabolism",{"v":0.828,"d":"8.28E-01"},{"v":0.0513,"d":"5.13E-02"},"GOT1,GOT2"]
["Leptin Signaling in Obesity",{"v":0.819,"d":"8.19E-01"},{"v":0.0385,"d":"3.85E-02"},"PIK3C2B,ADCY2,PLCG1"]
["Aminosugars Metabolism",{"v":0.819,"d":"8.19E-01"},{"v":0.0417,"d":"4.17E-02"},"PDE4A,CHIA,PDE4D"]
["Prolactin Signaling",{"v":0.807,"d":"8.07E-01"},{"v":0.039,"d":"3.90E-02"},"PIK3C2B,PRKCQ,PLCG1"]
["Nucleotide Sugars Metabolism",{"v":0.801,"d":"8.01E-01"},{"v":0.111,"d":"1.11E-01"},"UGP2"]
["Ceramide Signaling",{"v":0.794,"d":"7.94E-01"},{"v":0.0366,"d":"3.66E-02"},"PIK3C2B,PPM1L,PPP2R5B"]
["cAMP-mediated signaling",{"v":0.787,"d":"7.87E-01"},{"v":0.0279,"d":"2.79E-02"},"ADCY2,CAMK2A,GNAO1,PDE4A,AKAP6,PDE4D"]
["Cyclins and Cell Cycle Regulation",{"v":0.782,"d":"7.82E-01"},{"v":0.0337,"d":"3.37E-02"},"E2F6,PPM1L,PPP2R5B"]
["Galactose Metabolism",{"v":0.773,"d":"7.73E-01"},{"v":0.0426,"d":"4.26E-02"},"UGP2,PGM1"]
["Systemic Lupus Erythematosus Signaling",{"v":0.773,"d":"7.73E-01"},{"v":0.0223,"d":"2.23E-02"},"SNRPN,LSM14B,PIK3C2B,LSM12,PLCG1"]
["FcγRIIB Signaling in B Lymphocytes",{"v":0.756,"d":"7.56E-01"},{"v":0.0377,"d":"3.77E-02"},"PIK3C2B,MAPK12"]
["Reelin Signaling in Neurons",{"v":0.746,"d":"7.46E-01"},{"v":0.0366,"d":"3.66E-02"},"PIK3C2B,MAPK12,VLDLR"]
["GNRH Signaling",{"v":0.74,"d":"7.40E-01"},{"v":0.0294,"d":"2.94E-02"},"ADCY2,PRKCQ,CAMK2A,MAPK12"]
["RAR Activation",{"v":0.712,"d":"7.12E-01"},{"v":0.0282,"d":"2.82E-02"},"RXRG,ADCY2,PRKCQ,MAPK12,PPARGC1A"]
["FXR/RXR Activation",{"v":0.702,"d":"7.02E-01"},{"v":0.046,"d":"4.60E-02"},"ABCB4,MAPK12,VLDLR,PPARGC1A"]
["Fructose and Mannose Metabolism",{"v":0.693,"d":"6.93E-01"},{"v":0.0392,"d":"3.92E-02"},"ALDOA,TPI1"]
["Cleavage and Polyadenylation of Pre-mRNA",{"v":0.688,"d":"6.88E-01"},{"v":0.0833,"d":"8.33E-02"},"WDR33"]
["PAK Signaling",{"v":0.681,"d":"6.81E-01"},{"v":0.0286,"d":"2.86E-02"},"PIK3C2B,CFL2,MAPK12"]
["EGF Signaling",{"v":0.678,"d":"6.78E-01"},{"v":0.0417,"d":"4.17E-02"},"PIK3C2B,PLCG1"]
["mTOR Signaling",{"v":0.676,"d":"6.76E-01"},{"v":0.0251,"d":"2.51E-02"},"PIK3C2B,PRKCQ,PRKAB2,PPM1L,PPP2R5B"]
["α-Adrenergic Signaling",{"v":0.671,"d":"6.71E-01"},{"v":0.0323,"d":"3.23E-02"},"ADCY2,PRKCQ,PLCG1"]
["FAK Signaling",{"v":0.671,"d":"6.71E-01"},{"v":0.0303,"d":"3.03E-02"},"PIK3C2B,TLN2,PLCG1"]
["Apoptosis Signaling",{"v":0.671,"d":"6.71E-01"},{"v":0.0319,"d":"3.19E-02"},"ENDOG,PRKCQ,PLCG1"]
["RAN Signaling",{"v":0.657,"d":"6.57E-01"},{"v":0.0556,"d":"5.56E-02"},"KPNA3"]
["Role of PI3K/AKT Signaling in the Pathogenesis of Influenza",{"v":0.637,"d":"6.37E-01"},{"v":0.0282,"d":"2.82E-02"},"KPNA3,PIK3C2B"]
["Toll-like Receptor Signaling",{"v":0.637,"d":"6.37E-01"},{"v":0.0392,"d":"3.92E-02"},"ECSIT,MAPK12"]
["Glutathione Metabolism",{"v":0.637,"d":"6.37E-01"},{"v":0.0508,"d":"5.08E-02"},"GSTA3,G6pd2,IDH2"]
["Granzyme B Signaling",{"v":0.629,"d":"6.29E-01"},{"v":0.0625,"d":"6.25E-02"},"ENDOG"]
["Granzyme A Signaling",{"v":0.629,"d":"6.29E-01"},{"v":0.0526,"d":"5.26E-02"},"HIST1H1A"]
["Role of IL-17A in Arthritis",{"v":0.624,"d":"6.24E-01"},{"v":0.0333,"d":"3.33E-02"},"PIK3C2B,MAPK12"]
["Natural Killer Cell Signaling",{"v":0.623,"d":"6.23E-01"},{"v":0.0283,"d":"2.83E-02"},"PIK3C2B,PRKCQ,PLCG1"]
["Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes",{"v":0.623,"d":"6.23E-01"},{"v":0.0316,"d":"3.16E-02"},"TLN2,PRKCQ,PLCG1"]
["Inositol Phosphate Metabolism",{"v":0.618,"d":"6.18E-01"},{"v":0.0286,"d":"2.86E-02"},"PIK3C2B,PRKCQ,DMPK,PLCG1"]
["Axonal Guidance Signaling",{"v":0.603,"d":"6.03E-01"},{"v":0.0212,"d":"2.12E-02"},"PIK3C2B,PRKCQ,TUBA8,CFL2,GNAO1,TUBA4A,ABLIM2,FZD9,TUBA3C/TUBA3D"]
["Parkinson's Signaling",{"v":0.603,"d":"6.03E-01"},{"v":0.0556,"d":"5.56E-02"},"MAPK12"]
["HIF1α Signaling",{"v":0.596,"d":"5.96E-01"},{"v":0.0286,"d":"2.86E-02"},"PIK3C2B,MAPK12,LDHB"]
["T Cell Receptor Signaling",{"v":0.596,"d":"5.96E-01"},{"v":0.0291,"d":"2.91E-02"},"PIK3C2B,PRKCQ,PLCG1"]
["Regulation of eIF4 and p70S6K Signaling",{"v":0.596,"d":"5.96E-01"},{"v":0.0237,"d":"2.37E-02"},"PIK3C2B,PPM1L,PPP2R5B,MAPK12"]
["Calcium-induced T Lymphocyte Apoptosis",{"v":0.587,"d":"5.87E-01"},{"v":0.0308,"d":"3.08E-02"},"PRKCQ,PLCG1"]
["Eicosanoid Signaling",{"v":0.587,"d":"5.87E-01"},{"v":0.0345,"d":"3.45E-02"},"PLA2G4E,PLA2G12A"]
["B Cell Receptor Signaling",{"v":0.582,"d":"5.82E-01"},{"v":0.0267,"d":"2.67E-02"},"PIK3C2B,PRKCQ,CAMK2A,MAPK12"]
["Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis",{"v":0.574,"d":"5.74E-01"},{"v":0.0215,"d":"2.15E-02"},"PIK3C2B,PRKCQ,CAMK2A,FRZB,GNAO1,PLCG1,FZD9"]
["IL-12 Signaling and Production in Macrophages",{"v":0.571,"d":"5.71E-01"},{"v":0.0259,"d":"2.59E-02"},"PIK3C2B,PRKCQ,MAPK12"]
["Integrin Signaling",{"v":0.568,"d":"5.68E-01"},{"v":0.0238,"d":"2.38E-02"},"PIK3C2B,TLN2,PLCG1,ITGB6,TTN"]
["Molecular Mechanisms of Cancer",{"v":0.564,"d":"5.64E-01"},{"v":0.0218,"d":"2.18E-02"},"PIK3C2B,E2F6,ADCY2,PRKCQ,CAMK2A,GNAO1,FZD9,MAPK12"]
["Glioblastoma Multiforme Signaling",{"v":0.548,"d":"5.48E-01"},{"v":0.0253,"d":"2.53E-02"},"PIK3C2B,E2F6,PLCG1,FZD9"]
["Induction of Apoptosis by HIV1",{"v":0.542,"d":"5.42E-01"},{"v":0.0308,"d":"3.08E-02"},"SLC25A4,MAPK12"]
["Myc Mediated Apoptosis Signaling",{"v":0.542,"d":"5.42E-01"},{"v":0.0328,"d":"3.28E-02"},"PIK3C2B,MAPK12"]
["Mitotic Roles of Polo-Like Kinase",{"v":0.532,"d":"5.32E-01"},{"v":0.0308,"d":"3.08E-02"},"PPM1L,PPP2R5B"]
["Role of Tissue Factor in Cancer",{"v":0.523,"d":"5.23E-01"},{"v":0.027,"d":"2.70E-02"},"PIK3C2B,CFL2,MAPK12"]
["Pyruvate Metabolism",{"v":0.521,"d":"5.21E-01"},{"v":0.0299,"d":"2.99E-02"},"ME3,LDHB"]
["Pancreatic Adenocarcinoma Signaling",{"v":0.516,"d":"5.16E-01"},{"v":0.0261,"d":"2.61E-02"},"PIK3C2B,E2F6,MAPK12"]
["Sphingosine-1-phosphate Signaling",{"v":0.516,"d":"5.16E-01"},{"v":0.0256,"d":"2.56E-02"},"PIK3C2B,ADCY2,PLCG1"]
["Estrogen-Dependent Breast Cancer Signaling",{"v":0.511,"d":"5.11E-01"},{"v":0.0308,"d":"3.08E-02"},"PIK3C2B,HSD17B7"]
["CD40 Signaling",{"v":0.502,"d":"5.02E-01"},{"v":0.029,"d":"2.90E-02"},"PIK3C2B,MAPK12"]
["IL-17A Signaling in Airway Cells",{"v":0.502,"d":"5.02E-01"},{"v":0.029,"d":"2.90E-02"},"PIK3C2B,MAPK12"]
["GM-CSF Signaling",{"v":0.502,"d":"5.02E-01"},{"v":0.0303,"d":"3.03E-02"},"PIK3C2B,CAMK2A"]
["Biosynthesis of Steroids",{"v":0.497,"d":"4.97E-01"},{"v":0.0476,"d":"4.76E-02"},"COX10"]
["Actin Cytoskeleton Signaling",{"v":0.492,"d":"4.92E-01"},{"v":0.0215,"d":"2.15E-02"},"PIK3C2B,CFL2,TTN,FGF13,MYH1"]
["Neurotrophin/TRK Signaling",{"v":0.492,"d":"4.92E-01"},{"v":0.0278,"d":"2.78E-02"},"PIK3C2B,PLCG1"]
["Role of NFAT in Regulation of the Immune Response",{"v":0.482,"d":"4.82E-01"},{"v":0.0211,"d":"2.11E-02"},"PIK3C2B,PRKCQ,GNAO1,PLCG1"]
["Gα12/13 Signaling",{"v":0.48,"d":"4.80E-01"},{"v":0.024,"d":"2.40E-02"},"PIK3C2B,CDH15,MAPK12"]
["Glycosphingolipid Biosynthesis - Neolactoseries",{"v":0.48,"d":"4.80E-01"},{"v":0.04,"d":"4.00E-02"},"ST8SIA5"]
["Glycine, Serine and Threonine Metabolism",{"v":0.474,"d":"4.74E-01"},{"v":0.0282,"d":"2.82E-02"},"PLCG1,GOT1"]
["Linoleic Acid Metabolism",{"v":0.465,"d":"4.65E-01"},{"v":0.026,"d":"2.60E-02"},"PLA2G4E,PLA2G12A"]
["Angiopoietin Signaling",{"v":0.465,"d":"4.65E-01"},{"v":0.0282,"d":"2.82E-02"},"PIK3C2B,GRB14"]
["IL-22 Signaling",{"v":0.464,"d":"4.64E-01"},{"v":0.0417,"d":"4.17E-02"},"MAPK12"]
["Tumoricidal Function of Hepatic Natural Killer Cells",{"v":0.464,"d":"4.64E-01"},{"v":0.0417,"d":"4.17E-02"},"ENDOG"]
["Arginine and Proline Metabolism",{"v":0.456,"d":"4.56E-01"},{"v":0.0274,"d":"2.74E-02"},"GOT1,GOT2"]
["IL-17A Signaling in Gastric Cells",{"v":0.448,"d":"4.48E-01"},{"v":0.04,"d":"4.00E-02"},"MAPK12"]
["Pentose and Glucuronate Interconversions",{"v":0.448,"d":"4.48E-01"},{"v":0.025,"d":"2.50E-02"},"UGP2"]
["Cardiac Hypertrophy Signaling",{"v":0.444,"d":"4.44E-01"},{"v":0.0216,"d":"2.16E-02"},"PIK3C2B,ADCY2,GNAO1,PLCG1,MAPK12"]
["Phospholipase C Signaling",{"v":0.435,"d":"4.35E-01"},{"v":0.0201,"d":"2.01E-02"},"PLA2G4E,ADCY2,PRKCQ,PLA2G12A,PLCG1"]
["Glycosphingolipid Biosynthesis - Globoseries",{"v":0.434,"d":"4.34E-01"},{"v":0.04,"d":"4.00E-02"},"ST8SIA5"]
["N-Glycan Degradation",{"v":0.434,"d":"4.34E-01"},{"v":0.037,"d":"3.70E-02"},"NEU2"]
["IL-17 Signaling",{"v":0.431,"d":"4.31E-01"},{"v":0.027,"d":"2.70E-02"},"PIK3C2B,MAPK12"]
["FLT3 Signaling in Hematopoietic Progenitor Cells",{"v":0.431,"d":"4.31E-01"},{"v":0.027,"d":"2.70E-02"},"PIK3C2B,MAPK12"]
["IL-3 Signaling",{"v":0.423,"d":"4.23E-01"},{"v":0.0274,"d":"2.74E-02"},"PIK3C2B,PRKCQ"]
["Small Cell Lung Cancer Signaling",{"v":0.423,"d":"4.23E-01"},{"v":0.0235,"d":"2.35E-02"},"PIK3C2B,RXRG"]
["PDGF Signaling",{"v":0.423,"d":"4.23E-01"},{"v":0.0274,"d":"2.74E-02"},"PIK3C2B,PLCG1"]
["Glycosphingolipid Biosynthesis - Ganglioseries",{"v":0.42,"d":"4.20E-01"},{"v":0.037,"d":"3.70E-02"},"ST8SIA5"]
["Role of JAK family kinases in IL-6-type Cytokine Signaling",{"v":0.42,"d":"4.20E-01"},{"v":0.0385,"d":"3.85E-02"},"MAPK12"]
["Crosstalk between Dendritic Cells and Natural Killer Cells",{"v":0.416,"d":"4.16E-01"},{"v":0.0217,"d":"2.17E-02"},"TLN2,CAMK2A"]
["BMP signaling pathway",{"v":0.416,"d":"4.16E-01"},{"v":0.026,"d":"2.60E-02"},"MAPK12,PITX2"]
["NRF2-mediated Oxidative Stress Response",{"v":0.409,"d":"4.09E-01"},{"v":0.0211,"d":"2.11E-02"},"GSTA3,PIK3C2B,PRKCQ,DNAJB5"]
["Sonic Hedgehog Signaling",{"v":0.406,"d":"4.06E-01"},{"v":0.0323,"d":"3.23E-02"},"DYRK1B"]
["NF-κB Activation by Viruses",{"v":0.401,"d":"4.01E-01"},{"v":0.0253,"d":"2.53E-02"},"PIK3C2B,PRKCQ"]
["Insulin Receptor Signaling",{"v":0.4,"d":"4.00E-01"},{"v":0.0226,"d":"2.26E-02"},"PPP1R14C,PIK3C2B,PPP1R3A"]
["4-1BB Signaling in T Lymphocytes",{"v":0.394,"d":"3.94E-01"},{"v":0.0303,"d":"3.03E-02"},"MAPK12"]
["Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes",{"v":0.373,"d":"3.73E-01"},{"v":0.0235,"d":"2.35E-02"},"PLCG1,MAPK12"]
["Leukocyte Extravasation Signaling",{"v":0.372,"d":"3.72E-01"},{"v":0.0206,"d":"2.06E-02"},"PIK3C2B,PRKCQ,PLCG1,MAPK12"]
["VDR/RXR Activation",{"v":0.366,"d":"3.66E-01"},{"v":0.0253,"d":"2.53E-02"},"RXRG,PRKCQ"]
["G Protein Signaling Mediated by Tubby",{"v":0.359,"d":"3.59E-01"},{"v":0.0263,"d":"2.63E-02"},"PLCG1"]
["Hepatic Cholestasis",{"v":0.348,"d":"3.48E-01"},{"v":0.0274,"d":"2.74E-02"},"ADCY2,PRKCQ,ABCB4,MAPK12"]
["IL-9 Signaling",{"v":0.339,"d":"3.39E-01"},{"v":0.0263,"d":"2.63E-02"},"PIK3C2B"]
["Inhibition of Angiogenesis by TSP1",{"v":0.339,"d":"3.39E-01"},{"v":0.0294,"d":"2.94E-02"},"MAPK12"]
["TGF-β Signaling",{"v":0.335,"d":"3.35E-01"},{"v":0.0225,"d":"2.25E-02"},"MAPK12,PITX2"]
["VEGF Signaling",{"v":0.335,"d":"3.35E-01"},{"v":0.0215,"d":"2.15E-02"},"PIK3C2B,PLCG1"]
["Role of CHK Proteins in Cell Cycle Checkpoint Control",{"v":0.329,"d":"3.29E-01"},{"v":0.0286,"d":"2.86E-02"},"E2F6"]
["IL-17A Signaling in Fibroblasts",{"v":0.329,"d":"3.29E-01"},{"v":0.0256,"d":"2.56E-02"},"MAPK12"]
["RANK Signaling in Osteoclasts",{"v":0.329,"d":"3.29E-01"},{"v":0.0215,"d":"2.15E-02"},"PIK3C2B,MAPK12"]
["Neuregulin Signaling",{"v":0.323,"d":"3.23E-01"},{"v":0.0206,"d":"2.06E-02"},"PRKCQ,PLCG1"]
["SAPK/JNK Signaling",{"v":0.323,"d":"3.23E-01"},{"v":0.0198,"d":"1.98E-02"},"PIK3C2B,MAPK12"]
["Atherosclerosis Signaling",{"v":0.318,"d":"3.18E-01"},{"v":0.0192,"d":"1.92E-02"},"PLA2G4E,PLA2G12A"]
["Factors Promoting Cardiogenesis in Vertebrates",{"v":0.312,"d":"3.12E-01"},{"v":0.0217,"d":"2.17E-02"},"PRKCQ,FZD9"]
["Neuroprotective Role of THOP1 in Alzheimer's Disease",{"v":0.311,"d":"3.11E-01"},{"v":0.0238,"d":"2.38E-02"},"IDE"]
["HMGB1 Signaling",{"v":0.302,"d":"3.02E-01"},{"v":0.0204,"d":"2.04E-02"},"PIK3C2B,MAPK12"]
["Mechanisms of Viral Exit from Host Cells",{"v":0.294,"d":"2.94E-01"},{"v":0.025,"d":"2.50E-02"},"PRKCQ"]
["Docosahexaenoic Acid (DHA) Signaling",{"v":0.294,"d":"2.94E-01"},{"v":0.0244,"d":"2.44E-02"},"PIK3C2B"]
["April Mediated Signaling",{"v":0.294,"d":"2.94E-01"},{"v":0.0238,"d":"2.38E-02"},"MAPK12"]
["Chronic Myeloid Leukemia Signaling",{"v":0.291,"d":"2.91E-01"},{"v":0.0192,"d":"1.92E-02"},"PIK3C2B,E2F6"]
["Thyroid Cancer Signaling",{"v":0.286,"d":"2.86E-01"},{"v":0.0222,"d":"2.22E-02"},"RXRG"]
["IL-6 Signaling",{"v":0.286,"d":"2.86E-01"},{"v":0.0204,"d":"2.04E-02"},"HSPB2,MAPK12"]
["Huntington's Disease Signaling",{"v":0.284,"d":"2.84E-01"},{"v":0.0172,"d":"1.72E-02"},"PIK3C2B,PRKCQ,HSPA1L,NAPB"]
["Tight Junction Signaling",{"v":0.283,"d":"2.83E-01"},{"v":0.0186,"d":"1.86E-02"},"PPM1L,PPP2R5B,MYH1"]
["B Cell Activating Factor Signaling",{"v":0.271,"d":"2.71E-01"},{"v":0.0227,"d":"2.27E-02"},"MAPK12"]
["Melanoma Signaling",{"v":0.264,"d":"2.64E-01"},{"v":0.0227,"d":"2.27E-02"},"PIK3C2B"]
["Type I Diabetes Mellitus Signaling",{"v":0.263,"d":"2.63E-01"},{"v":0.0171,"d":"1.71E-02"},"MAPK12,CPE"]
["Nicotinate and Nicotinamide Metabolism",{"v":0.263,"d":"2.63E-01"},{"v":0.02,"d":"2.00E-02"},"PRKCQ,DMPK"]
["Cholecystokinin/Gastrin-mediated Signaling",{"v":0.258,"d":"2.58E-01"},{"v":0.0198,"d":"1.98E-02"},"PRKCQ,MAPK12"]
["Clathrin-mediated Endocytosis Signaling",{"v":0.257,"d":"2.57E-01"},{"v":0.0178,"d":"1.78E-02"},"PIK3C2B,ITGB6,FGF13"]
["Retinoic acid Mediated Apoptosis Signaling",{"v":0.257,"d":"2.57E-01"},{"v":0.0154,"d":"1.54E-02"},"RXRG"]
["MSP-RON Signaling Pathway",{"v":0.257,"d":"2.57E-01"},{"v":0.0208,"d":"2.08E-02"},"PIK3C2B"]
["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis",{"v":0.247,"d":"2.47E-01"},{"v":0.0174,"d":"1.74E-02"},"PIK3C2B,FRZB,FZD9,MAPK12"]
["Rac Signaling",{"v":0.245,"d":"2.45E-01"},{"v":0.0169,"d":"1.69E-02"},"PIK3C2B,CFL2"]
["fMLP Signaling in Neutrophils",{"v":0.241,"d":"2.41E-01"},{"v":0.0169,"d":"1.69E-02"},"PIK3C2B,PRKCQ"]
["Calcium Signaling",{"v":0.241,"d":"2.41E-01"},{"v":0.0153,"d":"1.53E-02"},"CHRNA1,CAMK2A,MYH1"]
["Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency",{"v":0.238,"d":"2.38E-01"},{"v":0.0222,"d":"2.22E-02"},"WWP2"]
["Arachidonic Acid Metabolism",{"v":0.237,"d":"2.37E-01"},{"v":0.0164,"d":"1.64E-02"},"PLA2G4E,PLA2G12A"]
["OX40 Signaling Pathway",{"v":0.232,"d":"2.32E-01"},{"v":0.0108,"d":"1.08E-02"},"MAPK12"]
["Amyloid Processing",{"v":0.232,"d":"2.32E-01"},{"v":0.0185,"d":"1.85E-02"},"MAPK12"]
["TREM1 Signaling",{"v":0.226,"d":"2.26E-01"},{"v":0.0175,"d":"1.75E-02"},"PLCG1"]
["CNTF Signaling",{"v":0.226,"d":"2.26E-01"},{"v":0.0182,"d":"1.82E-02"},"PIK3C2B"]
["Androgen Signaling",{"v":0.226,"d":"2.26E-01"},{"v":0.0148,"d":"1.48E-02"},"PRKCQ,GNAO1"]
["RhoA Signaling",{"v":0.226,"d":"2.26E-01"},{"v":0.018,"d":"1.80E-02"},"CFL2,TTN"]
["CD27 Signaling in Lymphocytes",{"v":0.221,"d":"2.21E-01"},{"v":0.0179,"d":"1.79E-02"},"MAPK12"]
["Activation of IRF by Cytosolic Pattern Recognition Receptors",{"v":0.21,"d":"2.10E-01"},{"v":0.0152,"d":"1.52E-02"},"MAPK12"]
["ATM Signaling",{"v":0.21,"d":"2.10E-01"},{"v":0.0185,"d":"1.85E-02"},"MAPK12"]
["Lymphotoxin β Receptor Signaling",{"v":0.205,"d":"2.05E-01"},{"v":0.0175,"d":"1.75E-02"},"PIK3C2B"]
["Semaphorin Signaling in Neurons",{"v":0.205,"d":"2.05E-01"},{"v":0.0192,"d":"1.92E-02"},"CFL2"]
["Endometrial Cancer Signaling",{"v":0.205,"d":"2.05E-01"},{"v":0.0182,"d":"1.82E-02"},"PIK3C2B"]
["Role of BRCA1 in DNA Damage Response",{"v":0.2,"d":"2.00E-01"},{"v":0.0169,"d":"1.69E-02"},"E2F6"]
["IL-2 Signaling",{"v":0.2,"d":"2.00E-01"},{"v":0.0179,"d":"1.79E-02"},"PIK3C2B"]