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{"sheet":"Sheet0","index":0,"n_rows":133,"n_cols":4,"rows_kept":133,"flags":["formulas_cached_only"]}
["© 2000-2011 Ingenuity Systems, Inc. All rights reserved.",null,"Color indicates significant p-value"]
["Ingenuity Canonical Pathways"," -log(p-value)","Ratio","Molecules"]
["Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes",2.44,{"v":0.0421,"d":"4.21E-02"},"EZR,LYN,ACTG1,PRKCB"]
["G-Protein Coupled Receptor Signaling",1.92,{"v":0.0192,"d":"1.92E-02"},"PRLHR,GPR173,PTGIR,GPRC5A,GLP2R,FZD3,GPR113,ADCY7,CELSR2,PRKCB"]
["Factors Promoting Cardiogenesis in Vertebrates",1.64,{"v":0.0326,"d":"3.26E-02"},"FZD3,TDGF1,PRKCB"]
["Natural Killer Cell Signaling",{"v":1.6,"d":"1.60"},{"v":0.0283,"d":"2.83E-02"},"SH3BP2,Klra4 (includes others),PRKCB"]
["Mechanisms of Viral Exit from Host Cells",1.55,{"v":0.05,"d":"5.00E-02"},"ACTG1,PRKCB"]
["Leukocyte Extravasation Signaling",1.45,{"v":0.0206,"d":"2.06E-02"},"EZR,MMP11,ACTG1,PRKCB"]
["p70S6K Signaling",1.32,{"v":0.0242,"d":"2.42E-02"},"LYN,RPS6,PRKCB"]
["PI3K Signaling in B Lymphocytes",1.26,{"v":0.0221,"d":"2.21E-02"},"LYN,PIK3AP1,PRKCB"]
["Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza",1.26,{"v":0.0417,"d":"4.17E-02"},"IFNA1/IFNA13"]
["Glutamate Receptor Signaling",1.25,{"v":0.0323,"d":"3.23E-02"},"GRIN1,SLC17A2"]
["Phospholipase C Signaling",1.21,{"v":0.0161,"d":"1.61E-02"},"LYN,ARHGEF18,ADCY7,PRKCB"]
["GM-CSF Signaling",1.17,{"v":0.0303,"d":"3.03E-02"},"LYN,PRKCB"]
["Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza",1.16,{"v":0.0247,"d":"2.47E-02"},"FZD3,IFNA1/IFNA13"]
["B Cell Receptor Signaling",1.13,{"v":0.02,"d":"2.00E-02"},"LYN,PIK3AP1,PRKCB"]
["Tight Junction Signaling",1.08,{"v":0.0186,"d":"1.86E-02"},"TIAM1,SYMPK,ACTG1"]
["CXCR4 Signaling",1.08,{"v":0.0188,"d":"1.88E-02"},"LYN,ADCY7,PRKCB"]
["Crosstalk between Dendritic Cells and Natural Killer Cells",1.06,{"v":0.0217,"d":"2.17E-02"},"IFNA1/IFNA13,ACTG1"]
["Riboflavin Metabolism",{"v":0.995,"d":"1.00"},{"v":0.05,"d":"5.00E-02"},"ACPP"]
["CREB Signaling in Neurons",{"v":0.968,"d":"0.97"},{"v":0.0158,"d":"1.58E-02"},"GRIN1,ADCY7,PRKCB"]
["One Carbon Pool by Folate",{"v":0.943,"d":"0.94"},{"v":0.05,"d":"5.00E-02"},"TYMS"]
["C21-Steroid Hormone Metabolism",{"v":0.943,"d":"0.94"},{"v":0.0476,"d":"4.76E-02"},"Hsd3b4 (includes others)"]
["Melanocyte Development and Pigmentation Signaling",0.94,{"v":0.0227,"d":"2.27E-02"},"KIT,ADCY7"]
["VEGF Signaling",0.94,{"v":0.0215,"d":"2.15E-02"},"ACTG1,PRKCB"]
["mTOR Signaling",{"v":0.938,"d":"0.94"},{"v":0.0151,"d":"1.51E-02"},"RPS3A,RPS6,PRKCB"]
["Neuregulin Signaling",{"v":0.923,"d":"0.92"},{"v":0.0206,"d":"2.06E-02"},"RPS6,PRKCB"]
["α-Adrenergic Signaling",{"v":0.923,"d":"0.92"},{"v":0.0215,"d":"2.15E-02"},"ADCY7,PRKCB"]
["Virus Entry via Endocytic Pathways",{"v":0.914,"d":"0.91"},{"v":0.0215,"d":"2.15E-02"},"ACTG1,PRKCB"]
["Breast Cancer Regulation by Stathmin1",{"v":0.873,"d":"0.87"},{"v":0.015,"d":"1.50E-02"},"ARHGEF18,ADCY7,PRKCB"]
["Neuropathic Pain Signaling In Dorsal Horn Neurons",{"v":0.844,"d":"0.84"},{"v":0.0194,"d":"1.94E-02"},"GRIN1,PRKCB"]
["Role of JAK1, JAK2 and TYK2 in Interferon Signaling",{"v":0.839,"d":"0.84"},{"v":0.0385,"d":"3.85E-02"},"IFNA1/IFNA13"]
["Fc Epsilon RI Signaling",{"v":0.836,"d":"0.84"},{"v":0.019,"d":"1.90E-02"},"LYN,PRKCB"]
["IL-12 Signaling and Production in Macrophages",{"v":0.836,"d":"0.84"},{"v":0.0172,"d":"1.72E-02"},"IFNA1/IFNA13,PRKCB"]
["HGF Signaling",{"v":0.836,"d":"0.84"},{"v":0.0196,"d":"1.96E-02"},"ELF1,PRKCB"]
["Synaptic Long Term Potentiation",{"v":0.794,"d":"0.79"},{"v":0.019,"d":"1.90E-02"},"GRIN1,PRKCB"]
["Glycosphingolipid Biosynthesis - Ganglioseries",{"v":0.788,"d":"0.79"},{"v":0.037,"d":"3.70E-02"},"B4GALNT1"]
["IL-15 Production",{"v":0.788,"d":"0.79"},{"v":0.0333,"d":"3.33E-02"},"IFNA1/IFNA13"]
["Actin Cytoskeleton Signaling",{"v":0.781,"d":"0.78"},{"v":0.0129,"d":"1.29E-02"},"TIAM1,EZR,ACTG1"]
["Corticotropin Releasing Hormone Signaling",{"v":0.774,"d":"0.77"},{"v":0.0164,"d":"1.64E-02"},"ADCY7,PRKCB"]
["RhoA Signaling",{"v":0.768,"d":"0.77"},{"v":0.018,"d":"1.80E-02"},"EZR,ACTG1"]
["Renin-Angiotensin Signaling",{"v":0.762,"d":"0.76"},{"v":0.0175,"d":"1.75E-02"},"ADCY7,PRKCB"]
["Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza",{"v":0.757,"d":"0.76"},{"v":0.0227,"d":"2.27E-02"},"IFNA1/IFNA13"]
["Intrinsic Prothrombin Activation Pathway",{"v":0.757,"d":"0.76"},{"v":0.0312,"d":"3.12E-02"},"COL11A2"]
["Interferon Signaling",{"v":0.729,"d":"0.73"},{"v":0.0294,"d":"2.94E-02"},"IFNA1/IFNA13"]
["P2Y Purigenic Receptor Signaling Pathway",{"v":0.719,"d":"0.72"},{"v":0.016,"d":"1.60E-02"},"ADCY7,PRKCB"]
["Role of RIG1-like Receptors in Antiviral Innate Immunity",{"v":0.716,"d":"0.72"},{"v":0.0208,"d":"2.08E-02"},"IFNA1/IFNA13"]
["Synaptic Long Term Depression",{"v":0.708,"d":"0.71"},{"v":0.0147,"d":"1.47E-02"},"LYN,PRKCB"]
["Molecular Mechanisms of Cancer",{"v":0.704,"d":"0.70"},{"v":0.0109,"d":"1.09E-02"},"FZD3,ARHGEF18,ADCY7,PRKCB"]
["Circadian Rhythm Signaling",{"v":0.703,"d":"0.70"},{"v":0.0303,"d":"3.03E-02"},"GRIN1"]
["GNRH Signaling",{"v":0.696,"d":"0.70"},{"v":0.0147,"d":"1.47E-02"},"ADCY7,PRKCB"]
["Cellular Effects of Sildenafil (Viagra)",{"v":0.691,"d":"0.69"},{"v":0.0149,"d":"1.49E-02"},"ADCY7,ACTG1"]
["Colorectal Cancer Metastasis Signaling",{"v":0.681,"d":"0.68"},{"v":0.012,"d":"1.20E-02"},"FZD3,MMP11,ADCY7"]
["Human Embryonic Stem Cell Pluripotency",{"v":0.664,"d":"0.66"},{"v":0.0135,"d":"1.35E-02"},"FZD3,TDGF1"]
["Role of Cytokines in Mediating Communication between Immune Cells",{"v":0.646,"d":"0.65"},{"v":0.0182,"d":"1.82E-02"},"IFNA1/IFNA13"]
["Dendritic Cell Maturation",{"v":0.634,"d":"0.63"},{"v":0.011,"d":"1.10E-02"},"COL11A2,IFNA1/IFNA13"]
["Hepatic Cholestasis",{"v":0.629,"d":"0.63"},{"v":0.0137,"d":"1.37E-02"},"ADCY7,PRKCB"]
["Hepatic Fibrosis / Hepatic Stellate Cell Activation",{"v":0.629,"d":"0.63"},{"v":0.014,"d":"1.40E-02"},"BAMBI,IFNA1/IFNA13"]
["Chondroitin Sulfate Biosynthesis",{"v":0.625,"d":"0.63"},{"v":0.02,"d":"2.00E-02"},"CHSY3"]
["FcγRIIB Signaling in B Lymphocytes",{"v":0.606,"d":"0.61"},{"v":0.0189,"d":"1.89E-02"},"LYN"]
["Regulation of eIF4 and p70S6K Signaling",{"v":0.605,"d":"0.61"},{"v":0.0118,"d":"1.18E-02"},"RPS3A,RPS6"]
["Axonal Guidance Signaling",{"v":0.594,"d":"0.59"},{"v":0.00941,"d":"9.41E-03"},"SEMA4D,FZD3,SEMA4B,PRKCB"]
["Retinoic acid Mediated Apoptosis Signaling",{"v":0.587,"d":"0.59"},{"v":0.0154,"d":"1.54E-02"},"IFNA1/IFNA13"]
["MSP-RON Signaling Pathway",{"v":0.587,"d":"0.59"},{"v":0.0208,"d":"2.08E-02"},"ACTG1"]
["N-Glycan Biosynthesis",{"v":0.579,"d":"0.58"},{"v":0.0222,"d":"2.22E-02"},"ST6GAL1"]
["Aldosterone Signaling in Epithelial Cells",{"v":0.553,"d":"0.55"},{"v":0.0127,"d":"1.27E-02"},"SCNN1B,PRKCB"]
["TREM1 Signaling",{"v":0.546,"d":"0.55"},{"v":0.0175,"d":"1.75E-02"},"LAT2"]
["Role of PI3K/AKT Signaling in the Pathogenesis of Influenza",{"v":0.538,"d":"0.54"},{"v":0.0141,"d":"1.41E-02"},"IFNA1/IFNA13"]
["Systemic Lupus Erythematosus Signaling",{"v":0.526,"d":"0.53"},{"v":0.00893,"d":"8.93E-03"},"LYN,IFNA1/IFNA13"]
["Activation of IRF by Cytosolic Pattern Recognition Receptors",{"v":0.523,"d":"0.52"},{"v":0.0152,"d":"1.52E-02"},"IFNA1/IFNA13"]
["Endothelin-1 Signaling",{"v":0.522,"d":"0.52"},{"v":0.0119,"d":"1.19E-02"},"ADCY7,PRKCB"]
["Semaphorin Signaling in Neurons",{"v":0.516,"d":"0.52"},{"v":0.0192,"d":"1.92E-02"},"SEMA4D"]
["PPARα/RXRα Activation",{"v":0.511,"d":"0.51"},{"v":0.0112,"d":"1.12E-02"},"ADCY7,PRKCB"]
["EIF2 Signaling",{"v":0.511,"d":"0.51"},{"v":0.0093,"d":"9.30E-03"},"RPS3A,RPS6"]
["Calcium-induced T Lymphocyte Apoptosis",{"v":0.509,"d":"0.51"},{"v":0.0154,"d":"1.54E-02"},"PRKCB"]
["Eicosanoid Signaling",{"v":0.509,"d":"0.51"},{"v":0.0172,"d":"1.72E-02"},"PTGIR"]
["Thrombopoietin Signaling",{"v":0.502,"d":"0.50"},{"v":0.0169,"d":"1.69E-02"},"PRKCB"]
["RAR Activation",{"v":0.496,"d":"0.50"},{"v":0.0113,"d":"1.13E-02"},"ADCY7,PRKCB"]
["Wnt/β-catenin Signaling",{"v":0.493,"d":"0.49"},{"v":0.0116,"d":"1.16E-02"},"FZD3,BCL9"]
["Androgen and Estrogen Metabolism",{"v":0.489,"d":"0.49"},{"v":0.0127,"d":"1.27E-02"},"Hsd3b4 (includes others)"]
["NRF2-mediated Oxidative Stress Response",{"v":0.479,"d":"0.48"},{"v":0.0105,"d":"1.05E-02"},"ACTG1,PRKCB"]
["Role of NFAT in Cardiac Hypertrophy",{"v":0.475,"d":"0.48"},{"v":0.0102,"d":"1.02E-02"},"ADCY7,PRKCB"]
["ERK/MAPK Signaling",{"v":0.465,"d":"0.47"},{"v":0.0101,"d":"1.01E-02"},"ELF1,PRKCB"]
["CCR5 Signaling in Macrophages",{"v":0.464,"d":"0.46"},{"v":0.0118,"d":"1.18E-02"},"PRKCB"]
["Communication between Innate and Adaptive Immune Cells",{"v":0.453,"d":"0.45"},{"v":0.00971,"d":"9.71E-03"},"IFNA1/IFNA13"]
["Thrombin Signaling",{"v":0.437,"d":"0.44"},{"v":0.0101,"d":"1.01E-02"},"ADCY7,PRKCB"]
["Melatonin Signaling",{"v":0.431,"d":"0.43"},{"v":0.0143,"d":"1.43E-02"},"PRKCB"]
["Agrin Interactions at Neuromuscular Junction",{"v":0.431,"d":"0.43"},{"v":0.0147,"d":"1.47E-02"},"ACTG1"]
["Growth Hormone Signaling",{"v":0.431,"d":"0.43"},{"v":0.0141,"d":"1.41E-02"},"PRKCB"]
["Erythropoietin Signaling",{"v":0.426,"d":"0.43"},{"v":0.0135,"d":"1.35E-02"},"PRKCB"]
["Macropinocytosis Signaling",{"v":0.426,"d":"0.43"},{"v":0.0132,"d":"1.32E-02"},"PRKCB"]
["Chemokine Signaling",0.42,{"v":0.0145,"d":"1.45E-02"},"PRKCB"]
["LPS-stimulated MAPK Signaling",0.41,{"v":0.0127,"d":"1.27E-02"},"PRKCB"]
["IL-3 Signaling",0.41,{"v":0.0137,"d":"1.37E-02"},"PRKCB"]
["Basal Cell Carcinoma Signaling",0.41,{"v":0.0139,"d":"1.39E-02"},"FZD3"]
["PDGF Signaling",0.41,{"v":0.0137,"d":"1.37E-02"},"PRKCB"]
["Caveolar-mediated Endocytosis Signaling",{"v":0.406,"d":"0.41"},{"v":0.012,"d":"1.20E-02"},"ACTG1"]
["Leptin Signaling in Obesity",{"v":0.401,"d":"0.40"},{"v":0.0128,"d":"1.28E-02"},"ADCY7"]
["Dopamine Receptor Signaling",{"v":0.401,"d":"0.40"},{"v":0.013,"d":"1.30E-02"},"ADCY7"]
["cAMP-mediated signaling",{"v":0.397,"d":"0.40"},{"v":0.0093,"d":"9.30E-03"},"PTGIR,ADCY7"]
["NF-κB Activation by Viruses",{"v":0.396,"d":"0.40"},{"v":0.0127,"d":"1.27E-02"},"PRKCB"]
["Prolactin Signaling",{"v":0.396,"d":"0.40"},{"v":0.013,"d":"1.30E-02"},"PRKCB"]
["HER-2 Signaling in Breast Cancer",{"v":0.392,"d":"0.39"},{"v":0.0123,"d":"1.23E-02"},"PRKCB"]
["Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses",{"v":0.387,"d":"0.39"},{"v":0.0122,"d":"1.22E-02"},"IFNA1/IFNA13"]
["Acute Myeloid Leukemia Signaling",{"v":0.387,"d":"0.39"},{"v":0.0123,"d":"1.23E-02"},"KIT"]
["VDR/RXR Activation",{"v":0.374,"d":"0.37"},{"v":0.0127,"d":"1.27E-02"},"PRKCB"]
["Reelin Signaling in Neurons",{"v":0.374,"d":"0.37"},{"v":0.0122,"d":"1.22E-02"},"LYN"]
["Bladder Cancer Signaling",{"v":0.366,"d":"0.37"},{"v":0.0109,"d":"1.09E-02"},"MMP11"]
["CDK5 Signaling",{"v":0.354,"d":"0.35"},{"v":0.0112,"d":"1.12E-02"},"ADCY7"]
["TR/RXR Activation",0.35,{"v":0.0112,"d":"1.12E-02"},"SREBF2"]
["G Beta Gamma Signaling",{"v":0.346,"d":"0.35"},{"v":0.00971,"d":"9.71E-03"},"PRKCB"]
["FAK Signaling",{"v":0.346,"d":"0.35"},{"v":0.0101,"d":"1.01E-02"},"ACTG1"]
["Atherosclerosis Signaling",{"v":0.342,"d":"0.34"},{"v":0.00962,"d":"9.62E-03"},"COL11A2"]
["IL-1 Signaling",{"v":0.331,"d":"0.33"},{"v":0.0099,"d":"9.90E-03"},"ADCY7"]
["Amyotrophic Lateral Sclerosis Signaling",{"v":0.317,"d":"0.32"},{"v":0.00971,"d":"9.71E-03"},"GRIN1"]
["HIF1α Signaling",{"v":0.317,"d":"0.32"},{"v":0.00952,"d":"9.52E-03"},"MMP11"]
["Glioma Signaling",{"v":0.317,"d":"0.32"},{"v":0.00935,"d":"9.35E-03"},"PRKCB"]
["Cholecystokinin/Gastrin-mediated Signaling",{"v":0.301,"d":"0.30"},{"v":0.0099,"d":"9.90E-03"},"PRKCB"]
["Rac Signaling",{"v":0.292,"d":"0.29"},{"v":0.00847,"d":"8.47E-03"},"TIAM1"]
["fMLP Signaling in Neutrophils",{"v":0.289,"d":"0.29"},{"v":0.00847,"d":"8.47E-03"},"PRKCB"]
["Role of Tissue Factor in Cancer",{"v":0.289,"d":"0.29"},{"v":0.00901,"d":"9.01E-03"},"LYN"]
["Sphingosine-1-phosphate Signaling",{"v":0.286,"d":"0.29"},{"v":0.00855,"d":"8.55E-03"},"ADCY7"]
["14-3-3-mediated Signaling",{"v":0.281,"d":"0.28"},{"v":0.00847,"d":"8.47E-03"},"PRKCB"]
["CCR3 Signaling in Eosinophils",{"v":0.278,"d":"0.28"},{"v":0.00833,"d":"8.33E-03"},"PRKCB"]
["Androgen Signaling",{"v":0.278,"d":"0.28"},{"v":0.00741,"d":"7.41E-03"},"PRKCB"]
["Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency",{"v":0.275,"d":"0.28"},{"v":0.00877,"d":"8.77E-03"},"FZD3"]
["Type II Diabetes Mellitus Signaling",{"v":0.275,"d":"0.28"},{"v":0.00758,"d":"7.58E-03"},"PRKCB"]
["Insulin Receptor Signaling",0.24,{"v":0.00752,"d":"7.52E-03"},"SCNN1B"]
["Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis",{"v":0.234,"d":"0.23"},{"v":0.00613,"d":"6.13E-03"},"FZD3,PRKCB"]
["Ovarian Cancer Signaling",{"v":0.226,"d":"0.23"},{"v":0.00719,"d":"7.19E-03"},"FZD3"]
["Cardiac β-adrenergic Signaling",{"v":0.226,"d":"0.23"},{"v":0.00719,"d":"7.19E-03"},"ADCY7"]
["Relaxin Signaling",{"v":0.222,"d":"0.22"},{"v":0.0069,"d":"6.90E-03"},"ADCY7"]
["Pyrimidine Metabolism",0.22,{"v":0.00719,"d":"7.19E-03"},"TYMS"]