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["Age estimation with DMLE+2.3 for AMN mutation c.208-2A>G"]
[]
["All informative cases: 5 Jewish, 10 Muslim, and 1 mixed"]
["Total sample size = 16"]
["Total number of disease chromosomes sampled = 32"]
["Population of Jewish = 2 million"]
["Population of Muslims = 83 million"]
["Combined population = 85 million"]
["Generation age = 25 years"]
["Number of incidence / live birth"," 1 in 10,000"," 1 in 100,000"," 1 in 500,000"," 1 in 1,000,000"]
["Carrier frequency","1 in 100","1 in 316","1 in 707","1 in 1000"]
["Population",{"v":85000000,"d":"85,000,000"},{"v":85000000,"d":"85,000,000"},{"v":85000000,"d":"85,000,000"},{"v":85000000,"d":"85,000,000"}]
["# of carriers in the population","85000000 * (1/100)","85000000 * (1/316)","85000000 * (1/707)","85000000 * (1/1000)"]
[null,850000,268987,120226,85000]
["Proportion sampled","32/850000","32/268987","32/120226","32/85000"]
[null,3.8e-05,0.000119,0.000266,0.000376]
["growth rate =0.01"]
["age (generations)",1020,938,769,714]
["95% CI (generations)","(823 , 1325)","(696 , 1274)","(572 , 1144)","(568 , 1043)"]
["age (years)",25500,23450,19225,17850]
["95% CI (years)","(20575 , 33125)","(17400 , 31850)","(14300 , 28600)","(14200 , 26075)"]
["growth rate =0.015"]
["age (generations)",691,620,593,553]
["95% CI (generations)","(577 , 995)","(488 , 849)","(445 , 815)","(397 , 799)"]
["age (years)",17275,15500,14825,13825]
["95% CI (years)","(14425 , 24875)","(12200 , 21225)","(11125 , 20375)","(9925 , 19975)"]
["growth rate =0.02"]
["age (generations)",574,473,445,410]
["95% CI (generations)","(476 , 776)","(395 , 656)","(335 , 594)","(317 , 570)"]
["age (years)",14350,11825,11125,10250]
["95% CI (years)","(11900 , 19400)","(9875 , 16400)","(8375 , 14850)","(7925 , 14251)"]
["growth rate =0.025"]
["age (generations)",407,401,362,285]
["95% CI (generations)","(358 , 538)","(328 , 542)","(307 , 543)","(215 , 404)"]
["age (years)",10175,10025,9050,7125]
["95% CI (years)","(8950 , 13450)","(8200 , 13550)","(7675 , 13575)","(5375 , 10100)"]
["growth rate =0.03"]
["age (generations)",353,336,322,277]
["95% CI (generations)","(298 , 455)","(280 , 438)","(258 , 448)","(214 , 394)"]
["age (years)",8825,8400,8050,6925]
["95% CI (years)","(7450 , 11375)","(7000 , 10950)","(6450 , 11200)","(5350 , 9850)"]
[]
["Muslim only: "]
["Total sample size = 10"]
["Total number of disease chromosomes sampled = 20"]
[]
["Population of Muslims = 83 million"]
[]
["Generation age = 25 years"]
["Number of incidence / live birth"," 1 in 10,000"," 1 in 100,000"," 1 in 500,000"," 1 in 1,000,000"]
["Carrier frequency","1 in 100","1 in 316","1 in 707","1 in 1000"]
["Population",{"v":83000000,"d":"83,000,000"},{"v":83000000,"d":"83,000,000"},{"v":83000000,"d":"83,000,000"},{"v":83000000,"d":"83,000,000"}]
["# of carriers in the population","83000000 * (1/100)","83000000 * (1/316)","83000000 * (1/707)","83000000 * (1/1000)"]
[null,830000,262658,117398,83000]
["Proportion sampled","20/830000","20/262658","20/117398","20/83000"]
[null,2.4e-05,7.6e-05,0.00017,0.000241]
["growth rate =0.01"]
["age (generations)",827,769,760,707]
["95% CI (generations)","(643 , 1080)","(516 , 1125)","(545 , 1066)","(531 , 951)"]
["age (years)",20675,19225,19000,17675]
["95% CI (years)","(16075 , 27000)","(12900 , 28125)","(13625 , 26650)","(13275 , 23675)"]
["growth rate =0.015"]
["age (generations)",643,574,575,516]
["95% CI (generations)","(556 , 854)","(453 , 803)","(467 , 844)","(378 , 750)"]
["age (years)",16075,14350,14375,12900]
["95% CI (years)","(13900 , 21350)","(11325 , 20075)","(11675 , 21100)","(9450 , 18750)"]
["growth rate =0.02"]
["age (generations)",515,434,407,343]
["95% CI (generations)","(426 , 672)","(339 , 608)","(311 , 587)","(258 , 511)"]
["age (years)",12875,10850,10175,8575]
["95% CI (years)","(10650 , 16800)","(8475 , 15200)","(7775 , 14675)","(6450 , 12775)"]
["growth rate =0.025"]
["age (generations)",410,361,356,324]
["95% CI (generations)","(338 , 532)","(299 , 512)","(281 , 516)","(253 , 453)"]
["age (years)",10250,9025,8900,8100]
["95% CI (years)","(8450 , 13300)","(7425 , 12800)","(7025 , 12900)","(6325 , 11325)"]
["growth rate =0.03"]
["age (generations)",339,321,289,256]
["95% CI (generations)","(270 , 441)","(257 , 426)","(224 , 395)","(199 , 385)"]
["age (years)",8475,8025,7225,6400]
["95% CI (years)","(6750 , 11025)","(6425 , 10650)","(5600 , 9875)","(4975 , 9625)"]
[]
["Jewish only: "]
["Total sample size = 5"]
["Total number of disease chromosomes sampled = 10"]
[]
["Population of Jewish = 2 million"]
[]
["Generation age = 25 years"]
["Number of incidence / live birth"," 1 in 10,000"," 1 in 100,000"," 1 in 500,000"," 1 in 1,000,000"]
["Carrier frequency","1 in 100","1 in 316","1 in 707","1 in 1000"]
["Population",{"v":2000000,"d":"2,000,000"},{"v":2000000,"d":"2,000,000"},{"v":2000000,"d":"2,000,000"},{"v":2000000,"d":"2,000,000"}]
["# of carriers in the population","2000000 * (1/100)","2000000 * (1/316)","2000000 * (1/707)","2000000 * (1/1000)"]
[null,20000,6329,2829,2000]
["Proportion sampled","10/20000","10/6329","10/2829","10/2000"]
[null,0.0005,0.00156,0.00353,0.005]
["growth rate =0.01"]
["age (generations)",591,529,439,370]
["95% CI (generations)","(355 , 976)","(337 , 858)","(221 , 799)","(174 , 752)"]
["age (years)",14775,13225,10975,9250]
["95% CI (years)","(8875 , 24400)","(8425 , 21450)","(5525 , 19975)","(4350 , 18800)"]
["growth rate =0.015"]
["age (generations)",430,319,311,338]
["95% CI (generations)","(272 , 718)","(205 , 586)","(173 , 552)","(202 , 546)"]
["age (years)",10750,7975,7775,8450]
["95% CI (years)","(6800 , 17900)","(5125 , 14650)","(4325 , 13800)","(5050 , 13650)"]
["growth rate =0.02"]
["age (generations)",345,258,257,242]
["95% CI (generations)","(243 , 502)","(164 , 428)","(146 , 451)","(126 , 410)"]
["age (years)",8625,6450,6425,6050]
["95% CI (years)","(6075 , 12550)","(4100 , 10700)","(3650 , 11275)","(3150 , 10250) "]
["growth rate =0.025"]
["age (generations)",249,208,199,192]
["95% CI (generations)","(164 , 394)","(141 , 367)","(126 , 325)","(125 , 336)"]
["age (years)",6225,5200,4975,4800]
["95% CI (years)","(4100 , 9850)","(3525 , 9175)","(3150 , 8125)","(3125 , 8400)"]
["growth rate =0.03"]
["age (generations)",239,196,171,162]
["95% CI (generations)","(175 , 356)","(124 , 324)","(115 , 299)","(100 , 266)"]
["age (years)",5975,4900,4275,4050]
["95% CI (years)","(4375 , 8900)","(3100 , 8100)","(2875 , 7475)","(2500 , 6650)"]