<?xml version="1.0" encoding="UTF-8"?><sbml xmlns="http://www.sbml.org/sbml/level2/version3" level="2" version="3">  <model id="GSK3_p53_ATM_System">    <listOfUnitDefinitions>      <unitDefinition id="substance">        <listOfUnits>          <unit kind="item"/>        </listOfUnits>      </unitDefinition>    </listOfUnitDefinitions>    <listOfCompartments>      <compartment id="cell" size="1"/>    </listOfCompartments>    <listOfSpecies>      <species id="Mdm2" compartment="cell" initialAmount="5" hasOnlySubstanceUnits="true"/>      <species id="p53" compartment="cell" initialAmount="5" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_p53" compartment="cell" initialAmount="95" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_mRNA" compartment="cell" initialAmount="10" hasOnlySubstanceUnits="true"/>      <species id="p53_mRNA" compartment="cell" initialAmount="10" hasOnlySubstanceUnits="true"/>      <species id="ATMA" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="ATMI" compartment="cell" initialAmount="200" hasOnlySubstanceUnits="true"/>      <species id="p53_P" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_P" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="IR" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="ROS" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="basalROS" compartment="cell" initialAmount="10" hasOnlySubstanceUnits="true"/>      <species id="damDNA" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="E1" compartment="cell" initialAmount="100" hasOnlySubstanceUnits="true"/>      <species id="E2" compartment="cell" initialAmount="100" hasOnlySubstanceUnits="true"/>      <species id="E1_Ub" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="E2_Ub" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Proteasome" compartment="cell" initialAmount="500" hasOnlySubstanceUnits="true"/>      <species id="Ub" compartment="cell" initialAmount="4000" hasOnlySubstanceUnits="true"/>      <species id="p53DUB" compartment="cell" initialAmount="200" hasOnlySubstanceUnits="true"/>      <species id="Mdm2DUB" compartment="cell" initialAmount="200" hasOnlySubstanceUnits="true"/>      <species id="DUB" compartment="cell" initialAmount="200" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_p53_Ub" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_p53_Ub2" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_p53_Ub3" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_p53_Ub4" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_P1_p53_Ub4" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_Ub" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_Ub2" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_Ub3" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_Ub4" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_P_Ub" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_P_Ub2" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_P_Ub3" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_P_Ub4" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="p53_Ub4_Proteasome" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_Ub4_Proteasome" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Mdm2_P_Ub4_Proteasome" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="GSK3b" compartment="cell" initialAmount="500" hasOnlySubstanceUnits="true"/>      <species id="GSK3b_p53" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="GSK3b_p53_P" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Abeta" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="AggAbeta_Proteasome" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="AggAbeta" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="AbetaPlaque" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Tau" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Tau_P1" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Tau_P2" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="MT_Tau" compartment="cell" initialAmount="100" hasOnlySubstanceUnits="true"/>      <species id="AggTau" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="AggTau_Proteasome" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="Proteasome_Tau" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="PP1" compartment="cell" initialAmount="50" hasOnlySubstanceUnits="true"/>      <species id="NFT" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true"/>      <species id="ATP" compartment="cell" initialAmount="10000" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="true"/>      <species id="ADP" compartment="cell" initialAmount="1000" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="true"/>      <species id="AMP" compartment="cell" initialAmount="1000" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="true"/>      <species id="Source" compartment="cell" initialAmount="1" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="true"/>      <species id="Sink" compartment="cell" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="true"/>    </listOfSpecies>    <listOfParameters>      <parameter id="ksynp53mRNA" value="0.001"/>      <parameter id="kdegp53mRNA" value="0.0001"/>      <parameter id="ksynMdm2mRNA" value="0.0005"/>      <parameter id="kdegMdm2mRNA" value="0.0005"/>      <parameter id="ksynMdm2mRNAGSK3bp53" value="0.0007"/>      <parameter id="ksynp53" value="0.007"/>      <parameter id="kdegp53" value="0.005"/>      <parameter id="kbinMdm2p53" value="0.001155"/>      <parameter id="krelMdm2p53" value="1.155e-005"/>      <parameter id="kbinGSK3bp53" value="2e-006"/>      <parameter id="krelGSK3bp53" value="0.002"/>      <parameter id="ksynMdm2" value="0.000495"/>      <parameter id="kdegMdm2" value="0.01"/>      <parameter id="kbinE1Ub" value="0.0002"/>      <parameter id="kbinE2Ub" value="0.001"/>      <parameter id="kp53Ub" value="5e-005"/>      <parameter id="kp53PolyUb" value="0.01"/>      <parameter id="kbinProt" value="2e-006"/>      <parameter id="kactDUBp53" value="1e-007"/>      <parameter id="kactDUBProtp53" value="0.0001"/>      <parameter id="kactDUBMdm2" value="1e-007"/>      <parameter id="kMdm2Ub" value="4.56e-006"/>      <parameter id="kMdm2PUb" value="6.84e-006"/>      <parameter id="kMdm2PolyUb" value="0.00456"/>      <parameter id="kdam" value="0.08"/>      <parameter id="krepair" value="2e-005"/>      <parameter id="kactATM" value="0.0001"/>      <parameter id="kinactATM" value="0.0005"/>      <parameter id="kphosp53" value="0.0002"/>      <parameter id="kdephosp53" value="0.5"/>      <parameter id="kphosMdm2" value="2"/>      <parameter id="kdephosMdm2" value="0.5"/>      <parameter id="kphosMdm2GSK3b" value="0.005"/>      <parameter id="kphosMdm2GSK3bp53" value="0.5"/>      <parameter id="kphospTauGSK3bp53" value="0.1"/>      <parameter id="kphospTauGSK3b" value="0.0002"/>      <parameter id="kdephospTau" value="0.01"/>      <parameter id="kbinMTTau" value="0.1"/>      <parameter id="krelMTTau" value="0.0001"/>      <parameter id="ksynTau" value="8e-005"/>      <parameter id="kbinTauProt" value="1.925e-007"/>      <parameter id="kdegTau20SProt" value="0.01"/>      <parameter id="kaggTau" value="1e-008"/>      <parameter id="kaggTauP1" value="1e-008"/>      <parameter id="kaggTauP2" value="1e-007"/>      <parameter id="ktangfor" value="0.001"/>      <parameter id="kprodAbeta" value="5e-005"/>      <parameter id="kinhibprot" value="1e-005"/>      <parameter id="kdegAbeta" value="0.0001"/>      <parameter id="kaggAbeta" value="1e-008"/>      <parameter id="kpf" value="0.001"/>      <parameter id="ksynp53mRNAAbeta" value="1e-005"/>      <parameter id="kdamROS" value="1e-005"/>      <parameter id="kdamBasalROS" value="1e-009"/>      <parameter id="kgenROSAbeta" value="1e-005"/>      <parameter id="kproteff" value="1" constant="false"/>    </listOfParameters>    <listOfReactions>      <reaction id="p53mRNASynthesis" reversible="false">        <listOfReactants>          <speciesReference species="Source"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53_mRNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynp53mRNA </ci>              <ci> Source </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53mRNADegradation" reversible="false">        <listOfReactants>          <speciesReference species="p53_mRNA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Sink"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdegp53mRNA </ci>              <ci> p53_mRNA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2Synthesis" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_mRNA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_mRNA"/>          <speciesReference species="Mdm2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynMdm2 </ci>              <ci> Mdm2_mRNA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2mRNASynthesis1" reversible="false">        <listOfReactants>          <speciesReference species="p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53"/>          <speciesReference species="Mdm2_mRNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynMdm2mRNA </ci>              <ci> p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2mRNASynthesis2" reversible="false">        <listOfReactants>          <speciesReference species="p53_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53_P"/>          <speciesReference species="Mdm2_mRNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynMdm2mRNA </ci>              <ci> p53_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2mRNASynthesis3" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53"/>          <speciesReference species="Mdm2_mRNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynMdm2mRNAGSK3bp53 </ci>              <ci> GSK3b_p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2mRNASynthesis4" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53_P"/>          <speciesReference species="Mdm2_mRNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynMdm2mRNAGSK3bp53 </ci>              <ci> GSK3b_p53_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2mRNADegradation" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_mRNA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Sink"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdegMdm2mRNA </ci>              <ci> Mdm2_mRNA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="P53Mdm2Binding" reversible="false">        <listOfReactants>          <speciesReference species="p53"/>          <speciesReference species="Mdm2"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinMdm2p53 </ci>              <ci> p53 </ci>              <ci> Mdm2 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="P53Mdm2Release" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53"/>          <speciesReference species="Mdm2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> krelMdm2p53 </ci>              <ci> Mdm2_p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="GSK3p53Binding" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b"/>          <speciesReference species="p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinGSK3bp53 </ci>              <ci> GSK3b </ci>              <ci> p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="GSK3p53Release" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b"/>          <speciesReference species="p53"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> krelGSK3bp53 </ci>              <ci> GSK3b_p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="GSK3p53PBinding" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b"/>          <speciesReference species="p53_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53_P"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinGSK3bp53 </ci>              <ci> GSK3b </ci>              <ci> p53_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="GSK3_p53PRelease" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b"/>          <speciesReference species="p53_P"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> krelGSK3bp53 </ci>              <ci> GSK3b_p53_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="E1UbBinding" reversible="false">        <listOfReactants>          <speciesReference species="E1"/>          <speciesReference species="Ub"/>          <speciesReference species="ATP"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="E1_Ub"/>          <speciesReference species="AMP"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <divide/>              <apply>                <times/>                <ci> kbinE1Ub </ci>                <ci> E1 </ci>                <ci> Ub </ci>                <ci> ATP </ci>              </apply>              <apply>                <plus/>                <cn type="integer"> 5000 </cn>                <ci> ATP </ci>              </apply>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="E2UbBinding" reversible="false">        <listOfReactants>          <speciesReference species="E2"/>          <speciesReference species="E1_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="E2_Ub"/>          <speciesReference species="E1"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinE2Ub </ci>              <ci> E2 </ci>              <ci> E1_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2Ubiquitination" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2Ub </ci>              <ci> Mdm2 </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2polyUbiquitination1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub2"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2PolyUb </ci>              <ci> Mdm2_Ub </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2polyUbiquitination2" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub2"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub3"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2PolyUb </ci>              <ci> Mdm2_Ub2 </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2polyUbiquitination3" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub3"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub4"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2PolyUb </ci>              <ci> Mdm2_Ub3 </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2Deubiquitination4" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub4"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub3"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_Ub4 </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2Deubiquitination3" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub3"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub2"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_Ub3 </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2Deubiquitination2" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub2"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_Ub2 </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2Deubiquitination1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_Ub </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2ProteasomeBinding1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub4"/>          <speciesReference species="Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_Ub4_Proteasome"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinProt </ci>              <ci> Mdm2_Ub4 </ci>              <ci> Proteasome </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2Degradation" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_Ub4_Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Proteasome"/>          <speciesReference species="Ub" stoichiometry="4"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdegMdm2 </ci>              <ci> Mdm2_Ub4_Proteasome </ci>              <ci> kproteff </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Synthesis" reversible="false">        <listOfReactants>          <speciesReference species="p53_mRNA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53"/>          <speciesReference species="p53_mRNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynp53 </ci>              <ci> p53_mRNA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Monoubiquitination" reversible="false">        <listOfReactants>          <speciesReference species="E2_Ub"/>          <speciesReference species="Mdm2_p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53_Ub"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kp53Ub </ci>              <ci> E2_Ub </ci>              <ci> Mdm2_p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Polyubiquitination1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53_Ub2"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kp53PolyUb </ci>              <ci> Mdm2_p53_Ub </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Polyubiquitination2" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub2"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53_Ub3"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kp53PolyUb </ci>              <ci> Mdm2_p53_Ub2 </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Polyubiquitination3" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub3"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53_Ub4"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kp53PolyUb </ci>              <ci> Mdm2_p53_Ub3 </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Deubiqutination4" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub4"/>          <speciesReference species="p53DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53_Ub3"/>          <speciesReference species="p53DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBp53 </ci>              <ci> Mdm2_p53_Ub4 </ci>              <ci> p53DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Deubiquitination3" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub3"/>          <speciesReference species="p53DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53_Ub2"/>          <speciesReference species="p53DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBp53 </ci>              <ci> Mdm2_p53_Ub3 </ci>              <ci> p53DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Deubiquitination2" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub2"/>          <speciesReference species="p53DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53_Ub"/>          <speciesReference species="p53DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBp53 </ci>              <ci> Mdm2_p53_Ub2 </ci>              <ci> p53DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53Deubiquitination1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub"/>          <speciesReference species="p53DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_p53"/>          <speciesReference species="p53DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBp53 </ci>              <ci> Mdm2_p53_Ub </ci>              <ci> p53DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2GSK3phosphorylation1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub4"/>          <speciesReference species="GSK3b"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P1_p53_Ub4"/>          <speciesReference species="GSK3b"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphosMdm2GSK3b </ci>              <ci> Mdm2_p53_Ub4 </ci>              <ci> GSK3b </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2GSK3phosphorylation2" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub4"/>          <speciesReference species="GSK3b_p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P1_p53_Ub4"/>          <speciesReference species="GSK3b_p53"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphosMdm2GSK3bp53 </ci>              <ci> Mdm2_p53_Ub4 </ci>              <ci> GSK3b_p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2GSK3phosphorylation3" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_p53_Ub4"/>          <speciesReference species="GSK3b_p53_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P1_p53_Ub4"/>          <speciesReference species="GSK3b_p53_P"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphosMdm2GSK3bp53 </ci>              <ci> Mdm2_p53_Ub4 </ci>              <ci> GSK3b_p53_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53ProteasomeBinding1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P1_p53_Ub4"/>          <speciesReference species="Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53_Ub4_Proteasome"/>          <speciesReference species="Mdm2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinProt </ci>              <ci> Mdm2_P1_p53_Ub4 </ci>              <ci> Proteasome </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Degradationp53_Ub4" reversible="false">        <listOfReactants>          <speciesReference species="p53_Ub4_Proteasome"/>          <speciesReference species="ATP"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Ub" stoichiometry="4"/>          <speciesReference species="Proteasome"/>          <speciesReference species="ADP"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <divide/>              <apply>                <times/>                <ci> kdegp53 </ci>                <ci> kproteff </ci>                <ci> p53_Ub4_Proteasome </ci>                <ci> ATP </ci>              </apply>              <apply>                <plus/>                <cn type="integer"> 5000 </cn>                <ci> ATP </ci>              </apply>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauMTbinding" reversible="false">        <listOfReactants>          <speciesReference species="Tau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="MT_Tau"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinMTTau </ci>              <ci> Tau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauMTrelease" reversible="false">        <listOfReactants>          <speciesReference species="MT_Tau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Tau"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> krelMTTau </ci>              <ci> MT_Tau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Tauphosphorylation1" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53"/>          <speciesReference species="Tau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53"/>          <speciesReference species="Tau_P1"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphospTauGSK3bp53 </ci>              <ci> GSK3b_p53 </ci>              <ci> Tau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Tauphosphorylation2" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53"/>          <speciesReference species="Tau_P1"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53"/>          <speciesReference species="Tau_P2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphospTauGSK3bp53 </ci>              <ci> GSK3b_p53 </ci>              <ci> Tau_P1 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Tauphosphorylation3" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53_P"/>          <speciesReference species="Tau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53_P"/>          <speciesReference species="Tau_P1"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphospTauGSK3bp53 </ci>              <ci> GSK3b_p53_P </ci>              <ci> Tau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Tauphosphorylation4" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53_P"/>          <speciesReference species="Tau_P1"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b_p53_P"/>          <speciesReference species="Tau_P2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphospTauGSK3bp53 </ci>              <ci> GSK3b_p53_P </ci>              <ci> Tau_P1 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Tauphosphorylation5" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b"/>          <speciesReference species="Tau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b"/>          <speciesReference species="Tau_P1"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphospTauGSK3b </ci>              <ci> GSK3b </ci>              <ci> Tau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Tauphosphorylation6" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b"/>          <speciesReference species="Tau_P1"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="GSK3b"/>          <speciesReference species="Tau_P2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphospTauGSK3b </ci>              <ci> GSK3b </ci>              <ci> Tau_P1 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Taudephosphorylation1" reversible="false">        <listOfReactants>          <speciesReference species="Tau_P2"/>          <speciesReference species="PP1"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Tau_P1"/>          <speciesReference species="PP1"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdephospTau </ci>              <ci> Tau_P2 </ci>              <ci> PP1 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Taudephosphorylation2" reversible="false">        <listOfReactants>          <speciesReference species="Tau_P1"/>          <speciesReference species="PP1"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Tau"/>          <speciesReference species="PP1"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdephospTau </ci>              <ci> Tau_P1 </ci>              <ci> PP1 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauP1Aggregation1" reversible="false">        <listOfReactants>          <speciesReference species="Tau_P1" stoichiometry="2"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggTau" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggTauP1 </ci>              <ci> Tau_P1 </ci>              <apply>                <minus/>                <ci> Tau_P1 </ci>                <cn type="integer"> 1 </cn>              </apply>              <cn> 0.5 </cn>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauP1Aggregation2" reversible="false">        <listOfReactants>          <speciesReference species="Tau_P1"/>          <speciesReference species="AggTau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggTau" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggTauP1 </ci>              <ci> Tau_P1 </ci>              <ci> AggTau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauP2Aggregation1" reversible="false">        <listOfReactants>          <speciesReference species="Tau_P2" stoichiometry="2"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggTau" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggTauP2 </ci>              <ci> Tau_P2 </ci>              <apply>                <minus/>                <ci> Tau_P2 </ci>                <cn type="integer"> 1 </cn>              </apply>              <cn> 0.5 </cn>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauP2Aggregation2" reversible="false">        <listOfReactants>          <speciesReference species="Tau_P2"/>          <speciesReference species="AggTau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggTau" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggTauP2 </ci>              <ci> Tau_P2 </ci>              <ci> AggTau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauAggregation1" reversible="false">        <listOfReactants>          <speciesReference species="Tau" stoichiometry="2"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggTau" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggTau </ci>              <ci> Tau </ci>              <apply>                <minus/>                <ci> Tau </ci>                <cn type="integer"> 1 </cn>              </apply>              <cn> 0.5 </cn>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauAggregation2" reversible="false">        <listOfReactants>          <speciesReference species="Tau"/>          <speciesReference species="AggTau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggTau" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggTau </ci>              <ci> Tau </ci>              <ci> AggTau </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TangleFormation1" reversible="false">        <listOfReactants>          <speciesReference species="AggTau" stoichiometry="2"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="NFT" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ktangfor </ci>              <ci> AggTau </ci>              <apply>                <minus/>                <ci> AggTau </ci>                <cn type="integer"> 1 </cn>              </apply>              <cn> 0.5 </cn>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TangleFormation2" reversible="false">        <listOfReactants>          <speciesReference species="AggTau"/>          <speciesReference species="NFT"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="NFT" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ktangfor </ci>              <ci> AggTau </ci>              <ci> NFT </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="ProteasomeInhibitionAggTau" reversible="false">        <listOfReactants>          <speciesReference species="AggTau"/>          <speciesReference species="Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggTau_Proteasome"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kinhibprot </ci>              <ci> AggTau </ci>              <ci> Proteasome </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Abetaproduction1" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Abeta"/>          <speciesReference species="GSK3b_p53"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kprodAbeta </ci>              <ci> GSK3b_p53 </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Abetaproduction2" reversible="false">        <listOfReactants>          <speciesReference species="GSK3b_p53_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Abeta"/>          <speciesReference species="GSK3b_p53_P"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kprodAbeta </ci>              <ci> GSK3b_p53_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="ProteasomeInhibitionAbeta" reversible="false">        <listOfReactants>          <speciesReference species="AggAbeta"/>          <speciesReference species="Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggAbeta_Proteasome"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kinhibprot </ci>              <ci> AggAbeta </ci>              <ci> Proteasome </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="AbetaDegradation" reversible="false">        <listOfReactants>          <speciesReference species="Abeta"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Sink"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdegAbeta </ci>              <ci> Abeta </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="AbetaAggregation1" reversible="false">        <listOfReactants>          <speciesReference species="Abeta" stoichiometry="2"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggAbeta"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggAbeta </ci>              <ci> Abeta </ci>              <apply>                <minus/>                <ci> Abeta </ci>                <cn type="integer"> 1 </cn>              </apply>              <cn> 0.5 </cn>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="AbetaAggregation2" reversible="false">        <listOfReactants>          <speciesReference species="Abeta"/>          <speciesReference species="AggAbeta"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggAbeta" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kaggAbeta </ci>              <ci> Abeta </ci>              <ci> AggAbeta </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="AbetaPlaqueFormation1" reversible="false">        <listOfReactants>          <speciesReference species="AggAbeta" stoichiometry="2"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AbetaPlaque" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kpf </ci>              <ci> AggAbeta </ci>              <apply>                <minus/>                <ci> AggAbeta </ci>                <cn type="integer"> 1 </cn>              </apply>              <cn> 0.5 </cn>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="AbetaPlaqueFormation2" reversible="false">        <listOfReactants>          <speciesReference species="AggAbeta"/>          <speciesReference species="AbetaPlaque"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AbetaPlaque" stoichiometry="2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kpf </ci>              <ci> AggAbeta </ci>              <ci> AbetaPlaque </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53transcriptionViaAbeta" reversible="false">        <listOfReactants>          <speciesReference species="Abeta"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53_mRNA"/>          <speciesReference species="Abeta"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynp53mRNAAbeta </ci>              <ci> Abeta </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="DNAdamage" reversible="false">        <listOfReactants>          <speciesReference species="IR"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="IR"/>          <speciesReference species="damDNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdam </ci>              <ci> IR </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="DNArepair" reversible="false">        <listOfReactants>          <speciesReference species="damDNA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Sink"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> krepair </ci>              <ci> damDNA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="ATMactivation" reversible="false">        <listOfReactants>          <speciesReference species="damDNA"/>          <speciesReference species="ATMI"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="damDNA"/>          <speciesReference species="ATMA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactATM </ci>              <ci> damDNA </ci>              <ci> ATMI </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53phosphorylation" reversible="false">        <listOfReactants>          <speciesReference species="p53"/>          <speciesReference species="ATMA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53_P"/>          <speciesReference species="ATMA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphosp53 </ci>              <ci> p53 </ci>              <ci> ATMA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="p53dephosphorylation" reversible="false">        <listOfReactants>          <speciesReference species="p53_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="p53"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdephosp53 </ci>              <ci> p53_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2phosphorylation" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2"/>          <speciesReference species="ATMA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P"/>          <speciesReference species="ATMA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kphosMdm2 </ci>              <ci> Mdm2 </ci>              <ci> ATMA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2dephosphorylation" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdephosMdm2 </ci>              <ci> Mdm2_P </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PUbiquitination" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2PUb </ci>              <ci> Mdm2_P </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PpolyUbiquitination1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub2"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2PolyUb </ci>              <ci> Mdm2_P_Ub </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PpolyUbiquitination2" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub2"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub3"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2PolyUb </ci>              <ci> Mdm2_P_Ub2 </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PpolyUbiquitination3" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub3"/>          <speciesReference species="E2_Ub"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub4"/>          <speciesReference species="E2"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kMdm2PolyUb </ci>              <ci> Mdm2_P_Ub3 </ci>              <ci> E2_Ub </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PDeubiquitination4" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub4"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub3"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_P_Ub4 </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PDeubiquitination3" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub3"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub2"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_P_Ub3 </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PDeubiquitination2" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub2"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_P_Ub2 </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PDeubiquitination1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub"/>          <speciesReference species="Mdm2DUB"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P"/>          <speciesReference species="Mdm2DUB"/>          <speciesReference species="Ub"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kactDUBMdm2 </ci>              <ci> Mdm2_P_Ub </ci>              <ci> Mdm2DUB </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PProteasomeBinding1" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub4"/>          <speciesReference species="Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Mdm2_P_Ub4_Proteasome"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinProt </ci>              <ci> Mdm2_P_Ub4 </ci>              <ci> Proteasome </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Mdm2PDegradation" reversible="false">        <listOfReactants>          <speciesReference species="Mdm2_P_Ub4_Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Proteasome"/>          <speciesReference species="Ub" stoichiometry="4"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdegMdm2 </ci>              <ci> Mdm2_P_Ub4_Proteasome </ci>              <ci> kproteff </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="ATMInactivation" reversible="false">        <listOfReactants>          <speciesReference species="ATMA"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="ATMI"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kinactATM </ci>              <ci> ATMA </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="AggAbetaROSproduction1" reversible="false">        <listOfReactants>          <speciesReference species="AggAbeta"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggAbeta"/>          <speciesReference species="ROS"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kgenROSAbeta </ci>              <ci> AggAbeta </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="AggAbetaROSproduction2" reversible="false">        <listOfReactants>          <speciesReference species="AggAbeta_Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="AggAbeta_Proteasome"/>          <speciesReference species="ROS"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kgenROSAbeta </ci>              <ci> AggAbeta_Proteasome </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="ROSDNAdamage" reversible="false">        <listOfReactants>          <speciesReference species="ROS"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="ROS"/>          <speciesReference species="damDNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdamROS </ci>              <ci> ROS </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="basalROSDNAdamage" reversible="false">        <listOfReactants>          <speciesReference species="basalROS"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="basalROS"/>          <speciesReference species="damDNA"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdamBasalROS </ci>              <ci> basalROS </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauSynthesis" reversible="false">        <listOfReactants>          <speciesReference species="Source"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Tau"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> ksynTau </ci>              <ci> Source </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="TauProteasomeBinding" reversible="false">        <listOfReactants>          <speciesReference species="Tau"/>          <speciesReference species="Proteasome"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Proteasome_Tau"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kbinTauProt </ci>              <ci> Tau </ci>              <ci> Proteasome </ci>            </apply>          </math>        </kineticLaw>      </reaction>      <reaction id="Tau20SProteasomeDegradation" reversible="false">        <listOfReactants>          <speciesReference species="Proteasome_Tau"/>        </listOfReactants>        <listOfProducts>          <speciesReference species="Proteasome"/>        </listOfProducts>        <kineticLaw>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <times/>              <ci> kdegTau20SProt </ci>              <ci> Proteasome_Tau </ci>            </apply>          </math>        </kineticLaw>      </reaction>    </listOfReactions>    <listOfEvents>      <event id="stressCell">        <trigger>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <geq/>              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> t </csymbol>              <cn> 3600 </cn>            </apply>          </math>        </trigger>        <listOfEventAssignments>          <eventAssignment variable="IR">            <math xmlns="http://www.w3.org/1998/Math/MathML">              <cn> 25 </cn>            </math>          </eventAssignment>        </listOfEventAssignments>      </event>      <event id="stopStress">        <trigger>          <math xmlns="http://www.w3.org/1998/Math/MathML">            <apply>              <geq/>              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> t </csymbol>              <cn> 3660 </cn>            </apply>          </math>        </trigger>        <listOfEventAssignments>          <eventAssignment variable="IR">            <math xmlns="http://www.w3.org/1998/Math/MathML">              <cn> 0 </cn>            </math>          </eventAssignment>        </listOfEventAssignments>      </event>    </listOfEvents>  </model></sbml>