4.0 GeneID: 51284 s664 PROTEIN pr119 GeneID: 148022 s609 PROTEIN pr2 GeneID: 10892 s638 PROTEIN pr111 s457 PROTEIN pr91 s524 PROTEIN pr12 2 GeneID: 10454 s609 PROTEIN pr5 s664 PROTEIN pr44 GeneID: 7124 s371 PROTEIN pr62 s535 PROTEIN pr91 s371 PROTEIN pr61 s372 PROTEIN pr37 s397 PROTEIN pr79 s370 PROTEIN pr61 GeneID: 7124 s504 PROTEIN pr62 s243 PROTEIN pr44 s505 PROTEIN pr30 s505 PROTEIN pr31 s524 PROTEIN pr13 s11 PROTEIN pr44 s509 PROTEIN pr2 GeneID: 3454 s521 PROTEIN pr50 GeneID: 3455 s521 PROTEIN pr51 s534 PROTEIN pr55 s534 PROTEIN pr54 s504 PROTEIN pr61 s504 PROTEIN pr64 s504 PROTEIN pr63 s520 PROTEIN pr63 s520 PROTEIN pr64 GeneID: 10454 s243 PROTEIN pr5 s88 PROTEIN pr32 2 s505 PROTEIN pr28 s504 PROTEIN pr84 GeneID: 1147 s508 PROTEIN pr8 s520 PROTEIN pr36 GeneID: 10454 s286 PROTEIN pr5 s286 PROTEIN pr44 s509 PROTEIN pr36 s525 PROTEIN pr86 s525 PROTEIN pr30 s525 PROTEIN pr31 s370 PROTEIN pr7 s333 PROTEIN pr6 2 s333 PROTEIN pr64 s371 PROTEIN pr64 s371 PROTEIN pr63 s11 PROTEIN pr5 s243 PROTEIN pr4 s372 PROTEIN pr2 s286 PROTEIN pr4 s664 PROTEIN pr71 s535 PROTEIN pr79 s535 PROTEIN pr89 s535 PROTEIN pr71 s397 PROTEIN pr89 s397 PROTEIN pr71 s455 PROTEIN pr2 s455 PROTEIN pr90 s455 PROTEIN pr79 s457 PROTEIN pr36 s457 PROTEIN pr2 s457 PROTEIN pr90 s457 PROTEIN pr79 s372 PROTEIN pr1 s509 PROTEIN pr1 s422 PROTEIN pr76 s426 PROTEIN pr89 s426 PROTEIN pr77 s426 PROTEIN pr71 s446 PROTEIN pr77 s446 PROTEIN pr78 GeneID: 7124 s370 PROTEIN pr62 s370 PROTEIN pr63 s455 PROTEIN pr91 s528 PROTEIN pr89 s462 PROTEIN pr77 s462 PROTEIN pr76 s462 PROTEIN pr89 s462 PROTEIN pr71 s462 PROTEIN pr72 s528 PROTEIN pr77 s478 PROTEIN pr80 s478 PROTEIN pr89 s478 PROTEIN pr71 s489 PROTEIN pr89 s489 PROTEIN pr72 s489 PROTEIN pr80 s495 PROTEIN pr2 s495 PROTEIN pr1 s397 PROTEIN pr91 GeneID: 3654 s510 PROTEIN pr73 GeneID: 3654 s397 PROTEIN pr73 s462 PROTEIN pr73 s528 PROTEIN pr73 s489 PROTEIN pr73 s504 PROTEIN pr65 GeneID: 7124 s520 PROTEIN pr62 s538 PROTEIN pr8 GeneID: 3551 s508 PROTEIN pr9 s538 PROTEIN pr9 s542 PROTEIN pr9 GeneID: 8517 s508 PROTEIN pr10 s523 PROTEIN pr13 s550 PROTEIN pr13 s550 PROTEIN pr12 2 s562 PROTEIN pr54 s562 PROTEIN pr55 s562 PROTEIN pr56 s523 PROTEIN pr12 2 s88 PROTEIN pr33 s575 PROTEIN pr33 s575 PROTEIN pr95 s592 PROTEIN pr100 s601 PROTEIN pr32 GeneID: 3665 s601 PROTEIN pr75 s520 PROTEIN pr84 s609 PROTEIN pr1 GeneID: 64170 s638 PROTEIN pr109 GeneID: 8915 s638 PROTEIN pr112 GeneID: 64135 s369 PROTEIN pr25 s538 PROTEIN pr10 s542 PROTEIN pr10 s507 PROTEIN pr8 s507 PROTEIN pr9 s507 PROTEIN pr10 s699 PROTEIN pr71 s699 PROTEIN pr72 s699 PROTEIN pr73 s664 PROTEIN pr72 s664 PROTEIN pr73 s534 PROTEIN pr56 s48 PROTEIN pr22 s681 PROTEIN pr19 s681 PROTEIN pr22 GeneID: 3725 s48 PROTEIN pr19 s527 PROTEIN pr71 s527 PROTEIN pr70 s699 PROTEIN pr120 GeneID: 51135 s397 PROTEIN pr72 GeneID: 10333 s528 PROTEIN pr78 GeneID: 7189 s286 PROTEIN pr3 GeneID: 7189 s510 PROTEIN pr3 GeneID: 7189 s583 PROTEIN pr3 GeneID: 3459 s721 PROTEIN pr122 GeneID: 3460 s721 PROTEIN pr123 GeneID: 7189 s11 PROTEIN pr3 s527 PROTEIN pr73 s527 PROTEIN pr72 GeneID: 4615 s528 PROTEIN pr71 GeneID: 7097 s422 PROTEIN pr77 GeneID: 57506 s369 PROTEIN pr115 s765 PROTEIN pr24 GeneID: 9641 s542 PROTEIN pr30 GeneID: 6885 s11 PROTEIN pr4 GeneID: 7187 s765 PROTEIN pr102 SQUARE OVAL SQUARE OVAL inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active inactive active inactive inactive inactive active inactive inactive active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active active active inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> GeneID: 1386 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> alternate names: NAK, T2K <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xh <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> TLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products.It is expressed constitutively on macrophages, dendritic cells, and B cells. In some other cell types, like the epithelial cells i t can be induced . The Molecular Pattern receptor Toll-like Receptor 4 is involved in recognition of Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria and is a component of the bacterial cell wall. It is a potent activator of the innate immune response in humans. In macrophages, lipid A (a form of LPS) activation of TLR4 triggers the biosynthesis of diverse mediators of inflammation, for eg TNF-alpha and IL1-beta, and activates the production of costimulatory molecules required for the adaptive immune response. TLR5 is the receptor for flagellin, the protein that forms bacterial flagella. TLR5 is expressed on epithelial cells as well as on macrophages and dendritic cells. Expression of TLR5 on intestinal epithelium is polarized such that TLR5 is expressed only on the basolateral side of the cell. <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> . Cytoplasm Nucleus Mitochondria Endosome inside UNKNOWN Gram(-)bacteria inside UNKNOWN VIRUS inside UNKNOWN Viral protein expression Flagellin is a protein and is the principal component of bacterial flagellum inside UNKNOWN flagellin inside SIMPLE_MOLECULE 2'5' Oligoadenylates GeneID: 6352 inside RNA rn7 GeneID: 3627 inside RNA rn6 IFNA2: GeneID: 3440 IFNA17: GeneID: 3451 IFNA1: GeneID: 3439 IFNA7: GeneID: 3444 IFNA5: GeneID: 3442 inside RNA rn12 GeneID: 3456 inside RNA rn9 GeneID: 3592 inside RNA rn18 GeneID: 3593 inside RNA rn17 GeneID: 3553 inside RNA rn20 GeneID: 51561 inside RNA rn16 GeneID: 3569 inside RNA rn8 GeneID: 3576 inside RNA rn11 GeneID: 3665 inside RNA rn4 GeneID: 64135 inside RNA rn10 GeneID: 4599 inside RNA rn3 OAS1: GeneID: 4938 OAS2: GeneID: 4939 OAS3: GeneID: 4940 inside RNA rn2 GeneID: 1263 inside RNA rn5 GeneID: 8651 inside RNA rn14 GeneID: 9021 inside RNA rn15 GeneID: 7124 inside RNA rn13 GeneID: 7128 inside PROTEIN pr69 GeneID: 207 inside PROTEIN pr38 GeneID: 207 inside PROTEIN pr38 Jun-Fos heterodimer: c-Jun: GeneID: 3725 JunD: GeneID: 3727 JunB: GeneID: 3726 c-Fos: GeneID: 2353 fosB: GeneID: 2354 inside PROTEIN pr105 inside PROTEIN pr22 inside PROTEIN pr22 inside PROTEIN pr22 GeneID: 3725 inside PROTEIN pr19 GeneID: 3725 inside PROTEIN pr19 GeneID: 64170 inside PROTEIN pr109 GeneID: 843 inside PROTEIN pr16 GeneID: 843 inside PROTEIN pr27 GeneID: 841 inside PROTEIN pr14 GeneID: 841 inside PROTEIN pr15 GeneID: 1387 inside PROTEIN pr33 GeneID: 1387 innerSurface PROTEIN pr33 GeneID: 1387 inside PROTEIN pr33 GeneID: 958 innerSurface PROTEIN pr99 GeneID: 5591 inside PROTEIN pr87 GeneID: 64581 innerSurface PROTEIN pr106 GeneID: 5595 inside PROTEIN pr93 GeneID: 5595 inside PROTEIN pr93 GeneID: 5595 inside PROTEIN pr93 GeneID: 5594 inside PROTEIN pr98 GeneID: 8772 inside PROTEIN pr7 GeneID: 3456 inside PROTEIN pr49 GeneID: 3456 inside PROTEIN pr49 GeneID: 4792 inside PROTEIN pr13 GeneID: 4792 inside PROTEIN pr13 GeneID: 9641 inside PROTEIN pr30 GeneID: 11213 inside PROTEIN pr92 GeneID: 3654 inside PROTEIN pr73 GeneID: 3654 inside PROTEIN pr73 GeneID: 51135 inside PROTEIN pr72 GeneID: 3660 inside PROTEIN pr43 GeneID: 3661 inside PROTEIN pr32 GeneID: 3661 inside PROTEIN pr32 2 GeneID: 3661 inside PROTEIN pr32 2 GeneID: 3661 inside PROTEIN pr32 2 GeneID: 3665 inside PROTEIN pr75 GeneID: 3665 inside PROTEIN pr75 2 GeneID: 10379 inside PROTEIN pr56 GeneID: 3716 inside PROTEIN pr53 GeneID: 3716 inside PROTEIN pr53 GeneID: 5599 inside PROTEIN pr18 GeneID: 79132 inside PROTEIN pr40 GeneID: 5598 inside PROTEIN pr47 GeneID: 57506 outerSurface PROTEIN pr115 GeneID: 23643 inside PROTEIN pr91 GeneID: 64135 inside PROTEIN pr25 GeneID: 5604 inside PROTEIN pr94 GeneID: 5605 inside PROTEIN pr97 GeneID: 4214 inside PROTEIN pr66 GeneID: 4215 inside PROTEIN pr74 GeneID: 4215 inside PROTEIN pr74 GeneID: 5606 inside PROTEIN pr20 GeneID: 6416 inside PROTEIN pr17 GeneID: 5608 inside PROTEIN pr23 GeneID: 4615 inside PROTEIN pr71 GeneID: 3576 inside PROTEIN pr28 p65-p50 dimer: p65: GeneID: 5970 p50: GeneID: 4790 inside PROTEIN pr12 2 p65-p50 dimer: p65: GeneID: 5970 p50: GeneID: 4790 inside PROTEIN pr12 2 GeneID: 4790 inside PROTEIN pr100 GeneID: 9020 inside PROTEIN pr68 GeneID: 79671 innerSurface PROTEIN pr103 GeneID: 10392 inside PROTEIN pr116 GeneID: 64127 inside PROTEIN pr117 OAS1: GeneID: 4938 OAS2: GeneID: 4939 OAS3: GeneID: 4940 inside PROTEIN pr57 GeneID: 2033 inside PROTEIN pr95 GeneID: 2033 inside PROTEIN pr95 PIK3CA: GeneID: 5290 PIK3CB: GeneID: 5291 PIK3CD: GeneID: 5293 PIK3CG: GeneID: 5294 inside PROTEIN pr37 GeneID: 5300 inside PROTEIN pr41 GeneID: 1263 inside PROTEIN pr6 GeneID: 1263 inside PROTEIN pr6 2 GeneID: 5524 inside PROTEIN pr82 PP2Calpha: GeneID: 5494 PP2C-eta: GeneID: 132160 PP2C-epsilon: GeneID: 151742 PP2C-beta: GeneID: 5495 PP2C-gamma: GeneID: 5496 inside PROTEIN pr85 GeneID: 8767 inside PROTEIN pr118 GeneID: 23586 inside PROTEIN pr24 GeneID: 23586 inside PROTEIN pr24 GeneID: 8737 inside PROTEIN pr36 GeneID: 8737 inside PROTEIN pr36 GeneID: 11035 inside PROTEIN pr48 GeneID: 54941 inside PROTEIN pr101 GeneID: 6041 inside PROTEIN pr58 GeneID: 5894 inside PROTEIN pr113 GeneID: 80143 Notes:SIKE is associated with TBK1 under physiological condition and dissociated from TBK1 upon viral infection or TLR3 stimulation.It is a suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF-3 but not NF-kappaB activation pathways. inside PROTEIN pr42 GeneID: 6772 inside PROTEIN pr54 GeneID: 6772 inside PROTEIN pr54 GeneID: 6773 inside PROTEIN pr55 GeneID: 6773 inside PROTEIN pr55 GeneID: 6714 inside PROTEIN pr107 GeneID: 6850 inside PROTEIN pr108 GeneID: 23118 inside PROTEIN pr44 GeneID: 6885 inside PROTEIN pr114 GeneID: 6885 inside PROTEIN pr4 GeneID: 10010 inside PROTEIN pr86 GeneID: 29110 inside PROTEIN pr31 GeneID: 353376 inside PROTEIN pr90 GeneID: 114609 inside PROTEIN pr89 GeneID: 7096 insideOfMembrane PROTEIN pr76 GeneID: 7098 outerSurface PROTEIN pr1 GeneID: 7098 transmembrane PROTEIN pr1 GeneID: 7098 innerSurface PROTEIN pr1 GeneID: 7099 insideOfMembrane PROTEIN pr79 GeneID: 7100 innerSurface PROTEIN pr80 GeneID: 10333 insideOfMembrane PROTEIN pr78 GeneID: 51284 outerSurface PROTEIN pr119 GeneID: 51311 innerSurface PROTEIN pr70 GeneID: 54106 outerSurface PROTEIN pr120 GeneID: 7132 innerSurface PROTEIN pr61 GeneID: 7124 inside PROTEIN pr62 inside PROTEIN pr96 GeneID: 1326 inside PROTEIN pr96 GeneID: 8717 inside PROTEIN pr63 GeneID: 7186 inside PROTEIN pr64 GeneID: 7187 inside PROTEIN pr102 GeneID: 7189 inside PROTEIN pr3 GeneID: 7189 inside PROTEIN pr3 GeneID: 148022 inside PROTEIN pr2 GeneID: 7706 inside PROTEIN pr104 GeneID: 7297 inside PROTEIN pr52 GeneID: 7297 inside PROTEIN pr52 GeneID: 7334 inside PROTEIN pr46 GeneID: 7314 inside PROTEIN pr39 GeneID: 7335 inside PROTEIN pr45 Ciap1: GeneID: 329 cIAP2: GeneID: 330 inside PROTEIN pr84 inside PROTEIN pr88 inside PROTEIN pr88 inside PROTEIN pr21 inside PHENOTYPE Apoptosis inside DEGRADED sa268_degraded inside DEGRADED sa406_degraded inside DEGRADED sa413_degraded inside DEGRADED sa91_degraded inside COMPLEX Bcl10-CARD9 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> Phosphorylated c-jun and phosphorylated ATF2 dimerise and bind to the IFNB enhancesome inside COMPLEX C-JUNp/ATF2p <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> Phosphorylated c-jun and phosphorylated ATF2 dimerise and bind to the IFNB enhancesome inside COMPLEX C-JUNp/ATF2p transmembrane COMPLEX IFNAR1-IFNAR2 complex inside COMPLEX IKK1-IKK2-NEMO-COMPLEX inside COMPLEX IKK1-IKK2p-NEMO COMPLEX inside COMPLEX IKK1-IKK2p-NEMO COMPLEX inside COMPLEX IKK1p-IKK2-NEMO COMPLEX inside COMPLEX IKKE-NAP1-TBK1COMPLEX inside COMPLEX IRAK1-TRAF6 complex inside COMPLEX IRF3-COMPLEX inside COMPLEX IRF3-IRF7 dimer inside COMPLEX IRF7-CBP-P300 transmembrane COMPLEX MDA5-MAV COMPLEX inside COMPLEX NFKB/IKB complex inside COMPLEX NFKB/IKB complex inside COMPLEX NFKB/IKB complex inside COMPLEX NFKB1-TPL2 inside COMPLEX PRK-TRAF2 inside COMPLEX STAT1-IRF9-STAT2 (ISGF3)complex inside COMPLEX STAT1-IRF9-STAT2 (ISGF3)complex inside COMPLEX TAK1-TAB1-TAB2 complex inside COMPLEX TAK1-TAB1-TAB2 complex inside COMPLEX TANK-TBK1-IKKE complex transmembrane COMPLEX TLR1-TLR2 transmembrane COMPLEX TLR1-TLR2-TIRAP-MYD88-IRAK4-IRAK1 innerSurface COMPLEX TLR2-TLR1-MYD88-TIRAP transmembrane COMPLEX TLR2-TLR6 complex innerSurface COMPLEX TLR2-TLR6-TIRAP-MYD88 -IRAK1-IRAK4complex transmembrane COMPLEX TLR3-RIP1-TRIF-TRAF6 transmembrane COMPLEX TLR3/TRIF innerSurface COMPLEX TLR3/TRIF transmembrane COMPLEX TLR3p-TRIF-PI3K transmembrane COMPLEX TLR4-RIP1-TICAM-2-TRIF-MD2 transmembrane COMPLEX TLR4-TIRAP-MYD88-IRAK4-IRAK1 transmembrane COMPLEX TLR4-TIRAP-MYD88-MD2 transmembrane COMPLEX TLR4-TRIF-TICAM-2-MD2 transmembrane COMPLEX TLR5-MYD88-IRAK4-IRAK1-TIRAP transmembrane COMPLEX TLR5-MYD88-TIRAP transmembrane COMPLEX TLR7-MYD88, IRAK1,IRAK4 COMPLEX outerSurface COMPLEX TLR8 -MYD88-IRAK4-IRAK1 complex outerSurface COMPLEX TLR9 -MYD88-IRAK4-IRAK1 complex inside COMPLEX TNF-cIAP1/2-RIP1-TRAF2 complex transmembrane COMPLEX TNFR1-TNF-FADD-TRADD complex innerSurface COMPLEX TNFR1-TNF-TRAF2-TRADD innerSurface COMPLEX TNFalpha-TRAF2-TNFR1-TRADD-RIP1-cIAP1/2 complex transmembrane COMPLEX TRAF6-CD40 inside COMPLEX TRAF6/TAB1/2/TAK1 inside PROTEIN pr32 2 inside PROTEIN pr25 inside DEGRADED RIP1-degraded inside DEGRADED TRIF-degraded inside PROTEIN pr3 GeneID: 959 inside PROTEIN pr121 innerSurface COMPLEX IFNGR1-IFNGR2 complex GeneID: 3458 inside PROTEIN pr124 GeneID: 3717 inside PROTEIN pr125 inside PROTEIN pr125 GeneID: 9021 inside PROTEIN pr126 GeneID: 8651 inside PROTEIN pr127 inside PROTEIN pr89 inside UNKNOWN LPS inside UNKNOWN CpG-DNA motifs inside UNKNOWN ssRNA inside UNKNOWN dsRNA inside UNKNOWN Peptidoglycan inside UNKNOWN gram (+) bacteria inside UNKNOWN Lipoteichoic acid TLR2 agonist Pam3csk4, is a synthetic tripalmitoylated lipopeptide that mimicks the acylated amino terminus of bacterial lipoproteins inside UNKNOWN Pam3csk4 Dectin-1 agonist Curdlan, is a high molecular weight polymer of glucose. Curdlan consists of β-(1,3)-linked glucose residues. It is produced by non pathogenic bacteria such as Agrobacterium biobar and also by some pathogenic bacteria such as Alcaligenes faecalis. inside UNKNOWN Curdlan Nod1 recognizes peptidoglycan (PGN)-related molecules containing the amino acid meso-diaminopimelic acid (meso-DAP) that are produced by most Gram-negative and certain Gram-positive bacteria. inside UNKNOWN iE-DAP Nod2 is activated by muramyl dipeptide (MDP), which is a conserved structure in all types of peptidoglycan (PGN). inside UNKNOWN MDP inside PROTEIN pr71 outerSurface PROTEIN pr76 inside PROTEIN pr8 outerSurface PROTEIN pr102 GeneID: 958 outerSurface PROTEIN pr99 inside PROTEIN pr128 GeneID: 7124 outerSurface PROTEIN pr62 GeneID: 148022 inside PROTEIN pr2 GeneID: 8737 inside PROTEIN pr36 GeneID: 4615 inside PROTEIN pr71 GeneID: 3654 inside PROTEIN pr73 GeneID: 51135 inside PROTEIN pr72 GeneID: 148022 innerSurface PROTEIN pr2 GeneID: 7099 innerSurface PROTEIN pr79 GeneID: 7097 insideOfMembrane PROTEIN pr77 inside DEGRADED RIG I degraded inside PROTEIN pr12 2 transmembrane PROTEIN pr115 transmembrane COMPLEX RIGI-MAV-TRAF3 complex inside PROTEIN pr129 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 9252186.DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E,Karin M.A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.Nature. 1997 Aug 7;388(6642):519-21 PMID: 7629157. Sun SC, Maggirwar SB, Harhaj E.Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. J Biol Chem. 1995 Aug 4;270(31):18347-51. DISSOCIATION 0.9781484880734403,-0.12371811899594576 0.2013842198932183,0.010045481510777776 0.08468818247998655,-0.3082989565639451 0.4138597685500347,0.3154254594962609 csa4 sa10 sa102 sa214 PMID: 9566918.Lin R,Heylbroeck C, Pitha PM,Hiscott J.Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol. 1998 May;18(5):2986-96. DISSOCIATION -0.1567965324328373,0.6733027569175025 csa11 sa275 sa262 sa387 PMID: 14560022.Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93. DISSOCIATION 1.001278772378523,-0.6579710144927526 csa43 sa543 sa10 PMID: 15485931.Beinke S, Robinson MJ, Hugunin M, Ley SC.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol. 2004 Nov;24(21):9658-67. PMID: 11297557. Salmeron A, Janzen J, Soneji Y, Bump N, Kamens J, Allen H, Ley SC.Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.J Biol Chem. 2001 Jun 22;276(25):22215-22. Epub 2001 Apr 10. PMID: 15199157. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC.IkappaB kinase is an essential component of the Tpl2 signaling pathway.Mol Cell Biol. 2004 Jul;24(13):6040-8. DISSOCIATION 0.014866789925138235,0.5389779650228803 csa46 sa391 sa406 csa6 PMID: 9162092 Deacon K, Blank JL. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.J Biol Chem. 1997 May 30;272(22):14489-96. HETERODIMER_ASSOCIATION 0.5640161711887661,-0.2892909840202833 0.7534661074194668,0.10995281344247587 -0.2805421580263179,0.5035100123734129 sa21 sa27 csa7 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> IPS-1 /MAV associated with the CARD region of RIG-I or MDA5 through its own CARD. PMID: 16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006). PMID: 16127453; Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-8 (2005). PMID: 16125763; Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-82 (2005). PMID: 16785313. .Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses.J Exp Med. 2006 Jul 10;203(7):1795-803. Epub 2006 Jun 19. HETERODIMER_ASSOCIATION 0.17610574747570595,0.34034983219817505 -0.025137606878088192,0.2804788202726112 sa32 sa30 csa8 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> [MAV --> IKKE-complex] PMID: 16281057. Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.EMBO J. 2005 Dec 7;24(23):4018-28. Epub 2005 Nov 10. PMID: 14560022.Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93. PMID: 16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006). PMID: 16452304; Sasai, M., Matsumoto, M. & Seya, T. The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC). J Biochem (Tokyo) 139, 171-5 (2006). PMID: 16309964; Johnson, C. L. & Gale, M., Jr. CARD games between virus and host get a new player. Trends Immunol 27, 1-4 (2006). PMID: 12692549; Fitzgerald, K. A. et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4, 491-6 (2003). PMID: 16914100 Paz S,Sun Q,Nakhaei P,Romieu-Mourez R,Goubau D,Julkunen I,Lin R,Hiscott J. Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):17-28. PMID: 17142768.Sasai M,Shingai M,Funami K,Yoneyama M, Fujita T,Matsumoto M,Seya T.NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.J Immunol. 2006 Dec 15;177(12):8676-83. HETERODIMER_ASSOCIATION 0.5725548813804178,-0.011675815786818422 0.35324797851070056,0.015241170190619435 sa540 sa51 sa250 csa10 csa8 sa98 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 15502848; Sarkar, S. N. et al. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 11, 1060-7 (2004). PMID: 15940673.Aksoy E,Vanden Berghe W, Detienne S,Amraoui Z,Fitzgerald KA,Haegeman G,Goldman M,Willems F. Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.Eur J Immunol. 2005 Jul;35(7):2200-9. HETERODIMER_ASSOCIATION -0.6136813681368132,0.3504950495049499 sa87 sa84 sa2 csa12 PMID: 17327220; Beichu Guo and Genhong ChengModulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK. J. Biol. Chem., Vol. 282, Issue 16, 11817-11826, April 20, 2007 PMID: 12133833. Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U.Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol Chem. 2002 Oct 4;277(40):37029-36. Epub 2002 Jul 19. PMID: 16281057. Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.EMBO J. 2005 Dec 7;24(23):4018-28. Epub 2005 Nov 10. PMID: 14560022.Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93. PMID: 16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006). PMID: 16452304; Sasai, M., Matsumoto, M. & Seya, T. The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC). J Biochem (Tokyo) 139, 171-5 (2006). PMID: 16309964; Johnson, C. L. & Gale, M., Jr. CARD games between virus and host get a new player. Trends Immunol 27, 1-4 (2006). PMID: 12692549; Fitzgerald, K. A. et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4, 491-6 (2003). PMID: 16914100 Paz S,Sun Q,Nakhaei P,Romieu-Mourez R,Goubau D,Julkunen I,Lin R,Hiscott J. Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):17-28. PMID: 17142768.Sasai M,Shingai M,Funami K,Yoneyama M, Fujita T,Matsumoto M,Seya T.NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.J Immunol. 2006 Dec 15;177(12):8676-83. PMID: 16125763. Seth RB, Sun L, Ea CK, Chen ZJ.Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell. 2005 Sep 9;122(5):669-82. HETERODIMER_ASSOCIATION 0.5010335733124267,-0.0822106588732856 sa68 sa69 sa254 csa27 csa15 PMID: 18200010; Chris B. Moore, Daniel T. Bergstralh, Joseph A. Duncan, Yu Lei, Thomas E. Morrison, Albert G. Zimmermann, Mary A. Accavitti-Loper, Victoria J. Madden, Lijun Sun, Zhengmao Ye, John D. Lich, Mark T. Heise, Zhijian Chen & Jenny P-Y. Ting. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451, 573-577 (31 January 2008) PMID: 16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006). PMID: 16127453; Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-8 (2005). PMID: 16125763; Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-82 (2005). PMID: 16153868; Xu, L.-G.; Wang, Y.-Y.; Han, K.-J.; Li, L.-Y.; Zhai, Z.; Shu, H.-B.VISA is an adapter protein required for virus-triggered IFN-beta signaling. Molec. Cell 19: 727-740, 2005. PMID: 16785313; Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses.J Exp Med. 2006 Jul 10;203(7):1795-803. Epub 2006 Jun 19. PMID: 15208624; Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730–737 (2004) PMID: 19893624; Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, Chuang TH, Ware CF, Lin R, Hiscott J.The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.PLoS Pathog. 2009 Nov;5(11):e1000650. Epub 2009 Nov 6. HETERODIMER_ASSOCIATION 0.32583391750397883,-0.1264430127627385 0.4567148468360216,0.2108270743621361 0.5833126660761714,0.0034720992028471898 0.5833480956598827,-0.002480070859160577 0.4865855269823447,-0.026237454886302913 0.4899438769520863,0.027503026242779782 -0.4892985318107659,0.41859706362153426 sa34 sa30 sa544 csa15 sa421 sa545 PMID:12975352. Sandor F, Latz E, Re F, Mandell L, Repik G, Golenbock DT, Espevik T, Kurt-Jones EA, Finberg RW.Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.J Cell Biol. 2003 Sep 15;162(6):1099-110. PMID: 16455995. Massari P, Visintin A,Gunawardana J, Halmen KA, King CA, Golenbock DT, Wetzler LM. Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.J Immunol. 2006 Feb 15;176(4):2373-80. HETERODIMER_ASSOCIATION 0.8649092882618277,-0.3418204372770077 -34.4889298892988,11.977859778597846 sa189 sa188 csa34 PMID: 14977973.Okusawa T, Fujita M, Nakamura J, Into T, Yasuda M, Yoshimura A,Hara Y, Hasebe A, Golenbock DT, Morita M, Kuroki Y, Ogawa T, Shibata K.Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.Infect Immun. 2004 Mar;72(3):1657-65. HETERODIMER_ASSOCIATION 0.9204500056719311,0.27059525629706194 10.496880998080634,6.651871401151673 sa317 sa189 csa36 PMID: 11325598. David E. Levy and Adolfo García-Sastrea. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 12604599. Yang H,Lin CH,Ma G,Baffi MO,Wathelet MG. Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators.J Biol Chem. 2003 May 2;278(18):15495-504. Epub 2003 Feb 25. HETERODIMER_ASSOCIATION 0.19566578000311452,0.3142700672821155 sa247 sa363 sa389 csa41 PMID: 14983024. Honda K, Mizutani T, Taniguchi T. Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2416-21. INHIBITION 0.4098360655737705,0.4918032786885256 sa99 sa11 PMID: 17030851. Hebner CM, Wilson R, Rader J, Bidder M, Laimins LA.Human papillomaviruses target the double-stranded RNA protein kinase pathway.J Gen Virol. 2006 Nov;87(Pt 11):3183-93. INHIBITION sa279 sa280 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 9804849.Li J, Peet GW, Pullen SS, Schembri-King J, Warren TC, Marcu KB, Kehry MR, Barton R, Jakes S. Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha.J Biol Chem. 1998 Nov 13;273(46):30736-41. PMID: 9244310. Regnier, C. H. et al. Identification and characterization of an IkappaB kinase. Cell 90, 373-83 (1997). PMID: 10837071. Karin, M. & Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18, 621-63 (2000). PMID: 16585540.Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 Apr 15;176(8):4520-4. STATE_TRANSITION 0.182465355251892,-0.10933146792421056 0.44664588182793885,0.3315644108885216 csa5 csa4 sa65 sa63 csa6 csa25 PMID: 11432733.Vattem KM,Staschke KA,Wek RC. Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).Eur J Biochem. 2001 Jul;268(13):3674-84.Click here to read Links PMID: 11337501.Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB, Ozato K, Hinnebusch AG. Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem. 2001 Jul 6;276(27):24946-58. Epub 2001 May 3. PMID: 15229216. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.J Biol Chem. 2004 Sep 3;279(36):37670-6. STATE_TRANSITION sa14 sa15 sa12 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 9162092; Deacon, K. & Blank, J. L. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272, 14489-96 (1997) PMID: 9244310. Regnier CH, Song HY, Gao X, Goeddel DV, Cao ZD, Rothe MTitle: Identification and characterization of an I kappa B kinase.CELL 90 (2): 373-383 JUL 25 1997 PMID: 9008162. Frank S. Lee, Jeremiah Hagler, Zhijian J. Chen and Tom Maniatis. Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway.Volume 88, Issue 2 , 24 January 1997, Pages 213-222 PMID: 8898208.Liu ZG, Hsu H, Goeddel DV, Karin M.Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. 1996 Nov 1;87(3):565-76. PMID: 9808624. Xia Y, Wu Z, Su B, Murray B, Karin M.JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.Genes Dev. 1998 Nov 1;12(21):3369-81. PMID: 10882101. Takaesu, G. et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5, 649-658 (2000) PMID: 11057907.Deng, L. et al. Activation of the IkappaB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000). PMID:11460167. Chen Wang1,2, Li Deng1,2, Mei Hong1, Giridhar R. Akkaraju1, Jun-ichiro Inoue3 and Zhijian J. Chen. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (19 July 2001) STATE_TRANSITION sa16 sa17 sa7 sa167 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 9162092; Deacon, K. & Blank, J. L. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272, 14489-96 (1997). PMID: 11390361. Cathy Tournier,Chen Dong, Tod K. Turner, Stephen N. Jones, Richard A. Flavell, and Roger J. Davis. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev. 2001 June 1; 15(11): 1419–1426. STATE_TRANSITION sa18 sa19 sa17 sa116 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 9162092; Deacon, K. & Blank, J. L. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272, 14489-96 (1997). STATE_TRANSITION sa20 sa21 sa19 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 8663074Tetsuo Moriguchi Dagger, Noriyo Kuroyanagi, Kyoko Yamaguchi par , Yukiko Gotoh Dagger, Kenji Irie par , Takahisa Kano, Kyoko Shirakabe Dagger, Yoshinao Muro, Hiroshi Shibuya, Kunihiro Matsumoto par , Eisuke Nishida Dagger par and Masatoshi Hagiwara A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3.JBC Volume 271, Number 23, Issue of June 7, 1996 pp. 13675-13679. STATE_TRANSITION sa22 sa23 sa7 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 9162092; Deacon, K. & Blank, J. L. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272, 14489-96 (1997). PMID: 11390361. Cathy Tournier,Chen Dong, Tod K. Turner, Stephen N. Jones, Richard A. Flavell, and Roger J. Davis. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev. 2001 June 1; 15(11): 1419–1426. PMID: 12702497.Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Gewirtz AT. TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G282-90. Epub 2003 Apr 17. PMID: 11323673.Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A.The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. STATE_TRANSITION 0.15324175000739437,0.003049479786145337 0.21308590937368965,-6.941213601976415E-4 0.7255540854494349,-0.020755754970047224 0.7308685107044113,0.020049573657890285 sa24 sa25 sa23 sa29 sa17 csa21 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 9162092; Deacon, K. & Blank, J. L. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272, 14489-96 (1997). STATE_TRANSITION sa26 sa27 sa25 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 15229216. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.J Biol Chem. 2004 Sep 3;279(36):37670-6. **[PMID: 8663074] Tetsuo Moriguchi Dagger, Noriyo Kuroyanagi, Kyoko Yamaguchi par , Yukiko Gotoh Dagger, Kenji Irie par , Takahisa Kano, Kyoko Shirakabe Dagger, Yoshinao Muro, Hiroshi Shibuya, Kunihiro Matsumoto par , Eisuke Nishida Dagger par and Masatoshi Hagiwara A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3.JBC Volume 271, Number 23, Issue of June 7, 1996 pp. 13675-13679. STATE_TRANSITION sa28 sa29 sa15 sa7 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 16210631. Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG, Schoenemeyer A, Yamamoto M, Akira S, Fitzgerald KA. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.J Immunol. 2005 Oct 15;175(8):5260-8. PMID: 16125763; Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-82 (2005). PMID: 16127453; Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-8 (2005). PMID: 16838639.Kato H, Takeuchi O, Akira S.Cell type specific involvement of RIG-I in antiviral responses. Nippon Rinsho 2006 Jul;64(7):1244-7. PMID: 16306043:Lin R, Yang L, Nakhaei P, Sun Q, Sharif-Askari E, Julkunen I, Hiscott J.Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.J Biol Chem. 2006 Jan 27;281(4):2095-103. Epub 2005 Nov 23. PMID: 17991829; Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM.DUBA: a deubiquitinase that regulates type I interferon production. Science. 2007 Dec 7;318(5856):1628-32. Epub 2007 Nov 8. STATE_TRANSITION 0.638528592942722,0.11764503936047577 0.6713599436424489,-0.060549946851137015 sa33 sa34 sa96 sa13 sa170 sa518 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> TLR3 is phophorylated at two specific tyrosine residues at the c terminal.TAK1-TAB1-TAB2 is a preformed complex, which is recruited by TRAF6 to TLR3-TRIF complex on the membrane. References: PMID: 12539043. Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.Nat Immunol. 2003 Feb;4(2):161-7. Epub 2003 Jan 21. PMID: 12855817; Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-3 (2003). PMID: 14982987; Jiang, Z., Mak, T. W., Sen, G. & Li, X. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A 101, 3533-8 (2004). PMID: 12609980; Jiang, Z. et al. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 278, 16713-9 (2003). STATE_TRANSITION 0.05060450503543734,-0.0517546074226054 0.5618390417685823,0.44811916182758793 sa5 sa1 csa1 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID:8943045. Shu HB, Takeuchi M, Goeddel DV. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13973-8. PMID: 8565075.Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.Cell. 1996 Jan 26;84(2):299-308.PMID: 16585540.Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 Apr 15;176(8):4520-4. PMID: 16585540.Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 Apr 15;176(8):4520-4. PMID: 9843495.Balachandran S,Kim CN,Yeh WC,Mak TW,Bhalla K,Barber GN. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.EMBO J. 1998 Dec 1;17(23):6888-902. STATE_TRANSITION 0.47703160584348225,-0.09415097483752977 0.514525356884973,0.095817363772702 sa61 sa63 sa60 csa24 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 16585540.Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 Apr 15;176(8):4520-4. STATE_TRANSITION sa64 sa65 sa60 PMID: 16309964.Cynthia L. Johnson and Michael Gale. CARD games between virus and host get a new player.Trends in Immunology Volume 27, Issue 1 , January 2006, Pages 1-4 PMID: 11562344. Silverman N, Maniatis T. NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev. 2001 Sep 15;15(18):2321-42. PMID: 16585540.Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 Apr 15;176(8):4520-4. PMID: 16585540.Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 Apr 15;176(8):4520-4. STATE_TRANSITION 0.16611658237955895,0.37218525419217396 csa8 sa60 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> TLR3 is phophorylated at two specific tyrosine residues at the c terminal. PMID: 15502848; Sarkar, S. N. et al. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 11, 1060-7 (2004). STATE_TRANSITION sa83 sa84 <body xmlns="http://www.w3.org/1999/xhtml"> PMID: 15502848.Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.Nat Struct Mol Biol. 2004 Nov;11(11):1060-7. 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STATE_TRANSITION 0.14755667506296533,-0.20607052896724198 0.8086146095717694,0.26727959697735315 sa434 sa437 PMID: 19122653 Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB.Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nat Immunol. 2009 Feb;10(2):203-13. Epub 2009 Jan 4. STATE_TRANSITION 0.01486580372620283,-0.14864570021638218 0.772956234953571,-0.06562683800234342 0.974361447751931,-0.04358182433445551 0.969675730190658,-0.002968115202113153 csa48 csa25 PMID: 19122653 Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB.Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nat Immunol. 2009 Feb;10(2):203-13. Epub 2009 Jan 4. STATE_TRANSITION sa437 sa440 PMID: 17277144. J.H. Park, Y.G. Kim, C. McDonald, T.D. Kanneganti, M. Hasegawa, M. Body-Malapel, N. Inohara and G. 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STATE_TRANSITION 0.5168312111320961,-0.4161591892033214 sa150 sa149 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> TLR3 is phophorylated at two specific tyrosine residues at the c terminal. 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STATE_TRANSITION sa82 sa83 <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> <body xmlns="http://www.w3.org/1999/xhtml"> TLR3 is phophorylated at two specific tyrosine residues at the c terminal.TAK1-TAB1-TAB2 is a preformed complex, which is recruited by TRAF6 to TLR3-TRIF complex on the membrane. 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STATE_TRANSITION 0.4477709098020881,0.4136724327305741 0.6335609011020629,0.21801279133972118 0.7187813339057656,0.3001462816050915 sa82 csa1 PMID:15596121.Fitzgerald KA, Rowe DC, Golenbock DT.Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 2004 Dec;6(15):1361-7. PMID: 12471095.Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O,Takeda K, Akira S.A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. PMID: 14556004.Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.Nat Immunol. 2003 Nov;4(11):1144-50. PMID: 11976338.Re F, Strominger JL. Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness.J Biol Chem. 2002 Jun 28;277(26):23427-32. Epub 2002 Apr 25. 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STATE_TRANSITION sa503 sa397 STATE_TRANSITION sa464 sa434 STATE_TRANSITION 0.030626190197949654,0.17932346004008526 csa15 sa542 STATE_TRANSITION 0.38126445726344027,0.10101605283358994 0.40696382551381793,0.00695986102158086 0.970811511167839,0.14235726787317438 sa542 csa2 TRANSCRIPTION 0.3320991901898812,-0.2040290237602722 0.4400447783421041,-0.028325382438948665 0.27013356475660244,0.07606155995001807 0.43620370037543765,0.3463748542906231 sa432 sa429 TRANSCRIPTION 0.1387772510293448,-0.13029641902199618 0.6072899066616302,0.3687111431899135 sa432 sa430 TRANSCRIPTION 0.07457331820233604,0.16146601716497044 0.8987671761268605,-0.2191891318662904 sa475 sa429 TRANSCRIPTION 0.13320306263167225,0.31751126067896207 0.9835439347324271,-0.03922571993235824 sa475 sa430 PMID: 11325598. David E. Levy and Adolfo García-Sastrea. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 12604599. Yang H,Lin CH,Ma G,Baffi MO,Wathelet MG. Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators.J Biol Chem. 2003 May 2;278(18):15495-504. Epub 2003 Feb 25. PMID: 12902474 Diego Laderach, Daniel Compagno, Olivier Danos William Vainchenker and Anne Galy.RNA Interference Shows Critical Requirement for NF-{kappa}B p50 in the Production of IL-12 by Human Dendritic Cells. Diego Laderach, Daniel Compagno, Olivier Danos William Vainchenker and Anne Galy. The Journal of Immunology, 2003, 171: 1750-1757.\ PMID: 11607032 Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8. TRANSCRIPTION 0.15523651602458388,0.2907899331273913 0.9334529201712529,-0.12465637202370505 sa475 sa431 PMID: 12902474 Diego Laderach, Daniel Compagno, Olivier Danos William Vainchenker and Anne Galy.RNA Interference Shows Critical Requirement for NF-{kappa}B p50 in the Production of IL-12 by Human Dendritic Cells. Diego Laderach, Daniel Compagno, Olivier Danos William Vainchenker and Anne Galy. The Journal of Immunology, 2003, 171: 1750-1757.\ PMID: 11607032 Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8. TRANSCRIPTION 0.07258568001840082,0.2594551966615186 csa11 sa431 PMID: 11163183. Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.Cell. 2000 Dec 22;103(7):1071-83. TRANSCRIPTION -0.009530459067885744,-0.1752138244019097 0.48690871007158343,-0.20221679176117213 0.49938907313667613,0.02722988305114349 sa378 sa392 PMID: 12702497.Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Gewirtz AT. TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G282-90. Epub 2003 Apr 17. PMID: 15069060. Rhee SH, Keates AC, Moyer MP, Pothoulakis C. MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells.J Biol Chem. 2004 Jun 11;279(24):25179-88. Epub 2004 Apr 6. TRANSCRIPTION sa378 sa375 PMID: 11325598. David E. Levy and Adolfo García-Sastreb. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 16002711.Austin BA, James C, Silverman RH, Carr DJ. Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection.J Immunol. 2005 Jul 15;175(2):1100-6. TRANSCRIPTION 0.343196814774708,-0.18337476867863955 0.5652840346187817,0.23227470699291075 csa17 sa141 PMID: 11325598. David E. Levy and Adolfo García-Sastreb. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 9919357. Jin HK,Yamashita T,Ochiai K,Haller O,Watanabe T.Characterization and expression of the Mx1 gene in wild mouse species.Biochem Genet. 1998 Oct;36(9-10):311-22. PMID: 1040079.Hefti HP, Frese M, Landis H, Di Paolo C, Aguzzi A, Haller O, Pavlovic J.Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol. 1999 Aug;73(8):6984-91. PMID: 10482599. Heim MH, Moradpour D, Blum HE. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway.J Virol. 1999 Oct;73(10):8469-75. TRANSCRIPTION 0.45943886596305195,-0.14126424901737522 0.54581186393367,0.13964980045717823 csa17 sa140 PMID: 11325598. David E. Levy and Adolfo García-Sastreb. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 15650175.Ryman KD,Meier KC,Meier KC,Nangle EM, Ragsdale SL,Korneeva NL,Korneeva NL,Rhoads RE, MacDonald MR, Klimstra WB.Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells.J Virol. 2005 Feb;79(3):1487-99. TRANSCRIPTION 0.09575529203147592,0.4189294026377066 0.6407514130555256,0.29435886068934103 0.594647013188565,0.09265211127118356 csa17 sa143 PMID: 11483745. Paludan SR.Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes. J Virol. 2001 Sep;75(17):8008-15. TRANSCRIPTION 0.012709787353238688,-0.08306295371257821 0.9898321701174124,0.0664503629700457 csa51 sa187 PMID: 16380379.Civas A,Genin P,Morin P, Lin R,Hiscott J. Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.J Biol Chem. 2006 Feb 24;281(8):4856-66. Epub 2005 Dec 27. TRANSCRIPTION 0.9005533340722489,0.29926080024554746 csa41 sa384 PMID: 10756005. Borgland SL, Bowen GP, Wong NC, Libermann TA, Muruve DA. Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB. J Virol. 2000 May;74(9):3941-7. TRANSCRIPTION 0.4099583509582545,-0.20367357563531208 0.6079214525103267,0.19479061595028302 sa102 sa186 PMID: 9891032.Lin R, Heylbroeck C, Genin P, Pitha PM, Hiscott J. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Mol Cell Biol. 1999 Feb;19(2):959-66. TRANSCRIPTION 0.9667012832875912,0.179415473629553 csa11 sa239 PMID: 16199137. Sankar S,Chan H,Romanow WJ,Li J,Bates RJ.IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines.Cell Signal. 2006 Jul;18(7):982-93. Epub 2005 Sep 30. TRANSCRIPTION 0.5983942497499317,-0.49022298152590604 csa11 sa186 PMID: 16380379.Civas A,Genin P,Morin P, Lin R,Hiscott J. Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.J Biol Chem. 2006 Feb 24;281(8):4856-66. Epub 2005 Dec 27. TRANSCRIPTION 0.5196003074558027,-0.4996156802459646 csa11 sa384 PMID: 11483745. Paludan SR.Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes. J Virol. 2001 Sep;75(17):8008-15. TRANSCRIPTION 0.40783616668945477,0.2227412910380866 0.6375886848062189,-0.1979323336827572 sa475 sa187 PMID: 12702497.Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Gewirtz AT. TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G282-90. Epub 2003 Apr 17. PMID: 11323673.Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A.The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. TRANSCRIPTION 0.15013174748537872,0.35720051215299975 sa102 sa375 PMID: 10920266; Suhara, W. et al. Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300. J Biochem (Tokyo) 128, 301-7 (2000). PMID: 10747925; Kim, T., Kim, T. Y., Lee, W. G., Yim, J. & Kim, T. K. Signaling pathways to the assembly of an interferon-beta enhanceosome. Chemical genetic studies with a small molecule. J Biol Chem 275, 16910-7 (2000). TRANSCRIPTION 0.6196961738221076,-0.0953751142523096 0.6428352101616603,0.05496989343605607 csa11 sa11 PMID: 14982987; Jiang, Z., Mak, T. W., Sen, G. & Li, X. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A 101, 3533-8 (2004). PMID: 10747925; Kim, T., Kim, T. Y., Lee, W. G., Yim, J. & Kim, T. K. Signaling pathways to the assembly of an interferon-beta enhanceosome. Chemical genetic studies with a small molecule. J Biol Chem 275, 16910-7 (2000). TRANSCRIPTION 0.1285212215360687,0.06905939261571581 0.47135206735476487,-0.38944875382924937 sa102 sa11 PMID: 11325598. David E. Levy and Adolfo García-Sastrea. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 12604599. Yang H,Lin CH,Ma G,Baffi MO,Wathelet MG. Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators.J Biol Chem. 2003 May 2;278(18):15495-504. Epub 2003 Feb 25. TRANSCRIPTION 0.19329185228820833,0.2532123264975503 0.8347630794155982,-0.2364603659659581 1.0096461838666393,-0.007363499134842577 csa47 sa11 PMID: 11325598. David E. Levy and Adolfo García-Sastrea. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 12604599. Yang H,Lin CH,Ma G,Baffi MO,Wathelet MG. Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators.J Biol Chem. 2003 May 2;278(18):15495-504. Epub 2003 Feb 25. TRANSCRIPTION 0.012284844596716304,-0.11015410655055113 csa41 sa11 GeneID: 3725 TRANSCRIPTION csa51 csa51 PMID: 16181431.Nakamichi K, Saiki M, Sawada M, Yamamuro Y, Morimoto K, Kurane I. Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways.J Neurochem. 2005 Oct;95(1):273-83. TRANSCRIPTION 0.9975222060359161,-0.04971573695677356 csa51 sa186 PMID: 16253303.Veckman V,Osterlund P,Fagerlund R,Melen K,Matikainen S,Julkunen I.TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells.Virology. 2006 Feb 5;345(1):96-104. Epub 2005 Oct 25. TRANSCRIPTION 0.012735337469264252,-0.1482074897985597 1.005405646839472,-0.06290821509435407 csa41 sa186 PMID: 16199137.Sankar S, Chan H, Romanow WJ, Li J, Bates RJ. IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines. Cell Signal. 2006 Jul;18(7):982-93. Epub 2005 Sep 30. PMID: 10799898. Genin P, Algarte M, Roof P, Lin R, Hiscott J. Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors. J Immunol. 2000 May 15;164(10):5352-61. TRANSCRIPTION 0.4740010655301048,-0.1618540223761329 0.578423015450189,0.14395311667554544 sa102 sa239 PMID: 10799898. Genin P, Algarte M, Roof P, Lin R, Hiscott J. Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors. J Immunol. 2000 May 15;164(10):5352-61. TRANSCRIPTION 0.025906007107430185,-0.18535565648696295 1.0067463560175605,-0.04826970221015037 csa41 sa239 PMID: 10760799. Boehlk S, Fessele S, Mojaat A, Miyamoto NG, Werner T, Nelson EL, Schlondorff D, Nelson PJ. ATF and Jun transcription factors, acting through an Ets/CRE promoter module, mediate lipopolysaccharide inducibility of the chemokine RANTES in monocytic Mono Mac 6 cells. Eur J Immunol. 2000 Apr;30(4):1102-12. TRANSCRIPTION -5.194689543088771E-4,-0.02383063827892462 0.9990055880017513,-0.04561865041966051 csa51 sa239 TRANSCRIPTION 0.2215665690355757,0.415300884325303 sa475 sa446 PMID: 12902474 Diego Laderach, Daniel Compagno, Olivier Danos William Vainchenker and Anne Galy.RNA Interference Shows Critical Requirement for NF-{kappa}B p50 in the Production of IL-12 by Human Dendritic Cells. Diego Laderach, Daniel Compagno, Olivier Danos William Vainchenker and Anne Galy. The Journal of Immunology, 2003, 171: 1750-1757.\ PMID: 11607032 Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8. TRANSCRIPTION 0.005956384473216669,-0.07694742333063864 csa51 sa446 PMID: 10747925; Kim, T., Kim, T. Y., Lee, W. G., Yim, J. & Kim, T. K. Signaling pathways to the assembly of an interferon-beta enhanceosome. Chemical genetic studies with a small molecule. J Biol Chem 275, 16910-7 (2000). PMID: 9162092; Deacon, K. & Blank, J. L. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272, 14489-96 (1997). TRANSCRIPTION 0.004213733991051072,0.05389501701457178 0.9981381175388382,-0.02381407728550622 csa51 sa11 PMID: 11325598. David E. Levy and Adolfo García-Sastreb. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 TRANSCRIPTION csa17 sa142 TRANSCRIPTION csa17 sa428 TRANSCRIPTION csa17 sa427 PMID: 14676839. Kang DC,Gopalkrishnan RV,Lin L,Randolph A,Valerie K,Pestka S,Fisher PB.Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene.Oncogene. 2004 Mar 4;23(9):1789-800 TRANSCRIPTION 0.1985661732009949,-0.24380735809235654 0.799776807272981,0.24584191184557147 sa125 sa346 PMID: 11325598. David E. Levy and Adolfo García-Sastreb. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156 PMID: 16002711.Austin BA, James C, Silverman RH, Carr DJ. Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection.J Immunol. 2005 Jul 15;175(2):1100-6. TRANSLATION sa141 sa144 PMID: 11432733.Vattem KM,Staschke KA,Wek RC. Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).Eur J Biochem. 2001 Jul;268(13):3674-84.Click here to read Links PMID: 11337501.Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB, Ozato K, Hinnebusch AG. Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem. 2001 Jul 6;276(27):24946-58. Epub 2001 May 3. PMID: 15229216. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.J Biol Chem. 2004 Sep 3;279(36):37670-6. TRANSLATION 0.8448537756888619,0.36204402134704017 sa143 sa14 PMID: 9857039 Song MM, Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J Biol Chem. 1998 Dec 25;273(52):35056-62. TRANSLATION 0.07572817906589469,0.041066102371499436 0.18457189210319191,-0.16140521439346622 0.9295097708829899,0.230272674247462 1.0385111977373405,0.020238508448014225 sa427 sa514 PMID: 9857039 Song MM, Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J Biol Chem. 1998 Dec 25;273(52):35056-62. TRANSLATION 0.6825918482331528,0.4634872307380207 sa428 sa515 PMID: 9566918.Lin R,Heylbroeck C, Pitha PM,Hiscott J.Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol. 1998 May;18(5):2986-96. PMID: 11867762. Karpova AY,Trost M,Murray JM,Cantley LC,Howley PM. 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TRANSPORT 0.1012953367875511,0.15492227979272472 0.8018134715025766,-0.3031088082901772 sa142 sa184 TRANSPORT 0.26357592034586563,-0.024236866238700472 0.2719605659635791,0.06694615485392497 csa7 csa51 PMID: 12609980. Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR . J Biol Chem. 2003 May 9;278(19):16713-9. UNKNOWN_TRANSITION 0.07733053203582685,0.2172619709577983 0.9648879007252735,-0.09864827891471073 sa15 csa2 PMID: 19122653 Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB.Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nat Immunol. 2009 Feb;10(2):203-13. Epub 2009 Jan 4. UNKNOWN_TRANSITION 0.04211705486947026,-0.18480544005002425 0.9927432859152732,0.03184173831483417 sa440 csa4 PMID: 19122653 Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB.Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nat Immunol. 2009 Feb;10(2):203-13. Epub 2009 Jan 4. UNKNOWN_TRANSITION 0.03074487102120349,-0.13483426318127828 0.9813215446873355,0.08191596438022636 sa436 sa393 PMID: 19122653 Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB.Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nat Immunol. 2009 Feb;10(2):203-13. Epub 2009 Jan 4. UNKNOWN_TRANSITION 0.023487995264858563,-0.15144738143426772 sa436 sa24 PMID: 17277144. J.H. Park, Y.G. Kim, C. McDonald, T.D. Kanneganti, M. Hasegawa, M. Body-Malapel, N. Inohara and G. 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Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, Inohara N.A. critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J. 2008 Jan 23;27(2):373-83. Epub 2007 Dec 13. UNKNOWN_TRANSITION 0.005951229702265914,-0.04034500143836095 0.9846558400943469,0.10402222472244682 sa452 sa7 PMID: 17277144. J.H. Park, Y.G. Kim, C. McDonald, T.D. Kanneganti, M. Hasegawa, M. Body-Malapel, N. Inohara and G. Nuñez, RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs, J Immunol 178 (2007), pp. 2380–2386. PMID: 17186025. J. da Silva Correia, Y. Miranda, N. Leonard, J. Hsu and R.J. Ulevitch, Regulation of Nod1-mediated signaling pathways, Cell Death Differ 14 (2007), pp. 830–839. PMID: 18079694. Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, Inohara N.A. critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J. 2008 Jan 23;27(2):373-83. Epub 2007 Dec 13. UNKNOWN_TRANSITION 0.0630739271459726,-0.18724274121369877 0.9734200068005514,0.1173675304190065 1.0132666112168607,0.005150839373426308 sa452 sa102