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initialConcentration="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class><celldesigner:proteinReference>pr13</celldesigner:proteinReference></celldesigner:speciesIdentity><celldesigner:listOfCatalyzedReactions><celldesigner:catalyzed reaction="r25"/></celldesigner:listOfCatalyzedReactions></celldesigner:extension></annotation></species><species metaid="CoSmad_N" id="CoSmad_N" name="CoSmad_N" compartment="n" initialConcentration="50.8"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class><celldesigner:proteinReference>pr14</celldesigner:proteinReference></celldesigner:speciesIdentity></celldesigner:extension></annotation></species><species metaid="I_Smad_mRNA1" id="I_Smad_mRNA1" name="I_Smad_mRNA1" compartment="n" initialConcentration="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class><celldesigner:proteinReference>pr15</celldesigner:proteinReference></celldesigner:speciesIdentity></celldesigner:extension></annotation></species><species metaid="I_Smad_mRNA2" id="I_Smad_mRNA2" name="I_Smad_mRNA2" compartment="c" initialConcentration="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class><celldesigner:proteinReference>pr16</celldesigner:proteinReference></celldesigner:speciesIdentity><celldesigner:listOfCatalyzedReactions><celldesigner:catalyzed reaction="r28"/></celldesigner:listOfCatalyzedReactions></celldesigner:extension></annotation></species><species metaid="I_Smad" id="I_Smad" name="I_Smad" compartment="c" initialConcentration="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class><celldesigner:proteinReference>pr17</celldesigner:proteinReference></celldesigner:speciesIdentity></celldesigner:extension></annotation></species><species metaid="s1" id="s1" name="s1" compartment="n" initialAmount="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>DEGRADED</celldesigner:class><celldesigner:name>s1</celldesigner:name></celldesigner:speciesIdentity></celldesigner:extension></annotation></species><species metaid="s2" id="s2" name="s2" compartment="c" initialAmount="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>DEGRADED</celldesigner:class><celldesigner:name>s2</celldesigner:name></celldesigner:speciesIdentity></celldesigner:extension></annotation></species><species metaid="s3" id="s3" name="s3" compartment="c" initialAmount="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>DEGRADED</celldesigner:class><celldesigner:name>s3</celldesigner:name></celldesigner:speciesIdentity></celldesigner:extension></annotation></species><species metaid="s4" id="s4" name="s4" compartment="c" initialAmount="0"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>DEGRADED</celldesigner:class><celldesigner:name>s4</celldesigner:name></celldesigner:speciesIdentity></celldesigner:extension></annotation></species></listOfSpecies><listOfParameters><parameter metaid="TGFb" id="TGFb" name="TGFb" value="0.2"/><parameter metaid="h" id="h" name="h" value="2"/><parameter metaid="k1" id="k1" name="k1" value="0.00015"/><parameter metaid="k2" id="k2" name="k2" value="0.023"/><parameter metaid="k3" id="k3" name="k3" value="0.01"/><parameter metaid="k4" id="k4" name="k4" value="0.01"/><parameter metaid="k7" id="k7" name="k7" value="0.000404"/><parameter metaid="k8" id="k8" name="k8" value="0.0026"/><parameter metaid="k9" id="k9" name="k9" value="0.0056"/><parameter metaid="k10" id="k10" name="k10" value="0.002"/><parameter metaid="k11" id="k11" name="k11" value="0.016"/><parameter metaid="k12" id="k12" name="k12" value="5.7"/><parameter metaid="k13" id="k13" name="k13" value="0.00657"/><parameter metaid="k5" id="k5" name="k5" value="0.01"/><parameter metaid="k6" id="k6" name="k6" value="0.1"/><parameter metaid="k14" id="k14" name="k14" value="0.0017"/><parameter metaid="k15" id="k15" name="k15" value="1"/><parameter metaid="k16" id="k16" name="k16" value="0.0008"/><parameter metaid="k17" id="k17" name="k17" value="0.001"/><parameter metaid="k18" id="k18" name="k18" value="0.002"/><parameter metaid="k19" id="k19" name="k19" value="0.001"/></listOfParameters><listOfReactions><reaction metaid="r1" id="r1" name="r1" reversible="false"><annotation><celldesigner:extension><celldesigner:name>r1</celldesigner:name><celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType><celldesigner:baseReactants><celldesigner:baseReactant species="TGFb_TGFbR" alias="sa1"><celldesigner:linkAnchor position="ENE"/></celldesigner:baseReactant></celldesigner:baseReactants><celldesigner:baseProducts><celldesigner:baseProduct species="TGFbR" alias="sa0"><celldesigner:linkAnchor position="WNW"/></celldesigner:baseProduct></celldesigner:baseProducts><celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"><celldesigner:listOfLineDirection><celldesigner:lineDirection index="0" value="unknown"/></celldesigner:listOfLineDirection></celldesigner:connectScheme><celldesigner:line width="1.0" color="ff000000"/></celldesigner:extension></annotation><listOfReactants><speciesReference metaid="CDMT00003" species="TGFb_TGFbR"><annotation><celldesigner:extension><celldesigner:alias>sa1</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfReactants><listOfProducts><speciesReference metaid="CDMT00004" species="TGFbR"><annotation><celldesigner:extension><celldesigner:alias>sa0</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfProducts><kineticLaw metaid="CDMT00005"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><times/><ci> k1 </ci><ci> TGFb_TGFbR </ci></apply></math></kineticLaw></reaction><reaction metaid="r2" id="r2" name="r2" reversible="false"><annotation><celldesigner:extension><celldesigner:name>r2</celldesigner:name><celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType><celldesigner:baseReactants><celldesigner:baseReactant species="TGFbR" alias="sa0"><celldesigner:linkAnchor position="W"/></celldesigner:baseReactant></celldesigner:baseReactants><celldesigner:baseProducts><celldesigner:baseProduct species="TGFb_TGFbR" alias="sa1"><celldesigner:linkAnchor position="E"/></celldesigner:baseProduct></celldesigner:baseProducts><celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"><celldesigner:listOfLineDirection><celldesigner:lineDirection index="0" value="unknown"/></celldesigner:listOfLineDirection></celldesigner:connectScheme><celldesigner:line width="1.0" color="ff000000"/></celldesigner:extension></annotation><listOfReactants><speciesReference metaid="CDMT00006" species="TGFbR"><annotation><celldesigner:extension><celldesigner:alias>sa0</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfReactants><listOfProducts><speciesReference metaid="CDMT00007" species="TGFb_TGFbR"><annotation><celldesigner:extension><celldesigner:alias>sa1</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfProducts><kineticLaw metaid="CDMT00008"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><times/><ci> k2 </ci><ci> TGFbR </ci><ci> TGFb </ci></apply></math></kineticLaw></reaction><reaction metaid="r3" id="r3" name="r3" reversible="false"><annotation><celldesigner:extension><celldesigner:name>r3</celldesigner:name><celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType><celldesigner:baseReactants><celldesigner:baseReactant species="TGFb_TGFbR" alias="sa1"><celldesigner:linkAnchor position="WNW"/></celldesigner:baseReactant></celldesigner:baseReactants><celldesigner:baseProducts><celldesigner:baseProduct species="TGFb_TGFbR_P" alias="sa2"><celldesigner:linkAnchor position="ENE"/></celldesigner:baseProduct></celldesigner:baseProducts><celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"><celldesigner:listOfLineDirection><celldesigner:lineDirection index="0" value="unknown"/></celldesigner:listOfLineDirection></celldesigner:connectScheme><celldesigner:line width="1.0" color="ff000000"/></celldesigner:extension></annotation><listOfReactants><speciesReference metaid="CDMT00009" species="TGFb_TGFbR"><annotation><celldesigner:extension><celldesigner:alias>sa1</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfReactants><listOfProducts><speciesReference metaid="CDMT00010" species="TGFb_TGFbR_P"><annotation><celldesigner:extension><celldesigner:alias>sa2</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfProducts><kineticLaw metaid="CDMT00011"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><times/><ci> k3 </ci><ci> TGFb_TGFbR </ci></apply></math></kineticLaw></reaction><reaction metaid="r4" id="r4" name="r4" reversible="false"><annotation><celldesigner:extension><celldesigner:name>r4</celldesigner:name><celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType><celldesigner:baseReactants><celldesigner:baseReactant species="TGFb_TGFbR_P" alias="sa2"><celldesigner:linkAnchor position="E"/></celldesigner:baseReactant></celldesigner:baseReactants><celldesigner:baseProducts><celldesigner:baseProduct species="TGFb_TGFbR" alias="sa1"><celldesigner:linkAnchor position="W"/></celldesigner:baseProduct></celldesigner:baseProducts><celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"><celldesigner:listOfLineDirection><celldesigner:lineDirection index="0" value="unknown"/></celldesigner:listOfLineDirection></celldesigner:connectScheme><celldesigner:line width="1.0" color="ff000000"/></celldesigner:extension></annotation><listOfReactants><speciesReference metaid="CDMT00012" species="TGFb_TGFbR_P"><annotation><celldesigner:extension><celldesigner:alias>sa2</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfReactants><listOfProducts><speciesReference metaid="CDMT00013" species="TGFb_TGFbR"><annotation><celldesigner:extension><celldesigner:alias>sa1</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfProducts><kineticLaw metaid="CDMT00014"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><times/><ci> k4 </ci><ci> TGFb_TGFbR_P </ci></apply></math></kineticLaw></reaction><reaction metaid="r5" id="r5" name="r5" reversible="false"><annotation><celldesigner:extension><celldesigner:name>r5</celldesigner:name><celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType><celldesigner:baseReactants><celldesigner:baseReactant species="TGFb_TGFbR_P" alias="sa2"><celldesigner:linkAnchor position="WNW"/></celldesigner:baseReactant></celldesigner:baseReactants><celldesigner:baseProducts><celldesigner:baseProduct species="I_Smad_TGFb_TGFbR_P" alias="sa3"><celldesigner:linkAnchor position="ENE"/></celldesigner:baseProduct></celldesigner:baseProducts><celldesigner:listOfReactantLinks><celldesigner:reactantLink 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metaid="CDMT00017" species="I_Smad_TGFb_TGFbR_P"><annotation><celldesigner:extension><celldesigner:alias>sa3</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfProducts><kineticLaw metaid="CDMT00018"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><times/><ci> k5 </ci><ci> TGFb_TGFbR_P </ci><ci> I_Smad </ci></apply></math></kineticLaw></reaction><reaction metaid="r6" id="r6" name="r6" reversible="false"><annotation><celldesigner:extension><celldesigner:name>r6</celldesigner:name><celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType><celldesigner:baseReactants><celldesigner:baseReactant species="I_Smad_TGFb_TGFbR_P" alias="sa3"><celldesigner:linkAnchor position="S"/></celldesigner:baseReactant></celldesigner:baseReactants><celldesigner:baseProducts><celldesigner:baseProduct species="TGFb_TGFbR" alias="sa1"><celldesigner:linkAnchor position="S"/></celldesigner:baseProduct></celldesigner:baseProducts><celldesigner:listOfProductLinks><celldesigner:productLink product="I_Smad" alias="sa16" targetLineIndex="-1,1"><celldesigner:linkAnchor position="NNE"/><celldesigner:line width="1.0" color="ff000000" type="Straight"/></celldesigner:productLink></celldesigner:listOfProductLinks><celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1"><celldesigner:listOfLineDirection><celldesigner:lineDirection index="0" value="unknown"/><celldesigner:lineDirection index="1" value="unknown"/><celldesigner:lineDirection index="2" value="unknown"/></celldesigner:listOfLineDirection></celldesigner:connectScheme><celldesigner:editPoints>1.795935659479886E-4,0.0818716412549444 1.0003934235041092,0.07978107149501928</celldesigner:editPoints><celldesigner:line width="1.0" color="ff000000"/></celldesigner:extension></annotation><listOfReactants><speciesReference metaid="CDMT00019" species="I_Smad_TGFb_TGFbR_P"><annotation><celldesigner:extension><celldesigner:alias>sa3</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfReactants><listOfProducts><speciesReference metaid="CDMT00020" species="TGFb_TGFbR"><annotation><celldesigner:extension><celldesigner:alias>sa1</celldesigner:alias></celldesigner:extension></annotation></speciesReference><speciesReference metaid="CDMT00021" species="I_Smad"><annotation><celldesigner:extension><celldesigner:alias>sa16</celldesigner:alias></celldesigner:extension></annotation></speciesReference></listOfProducts><kineticLaw metaid="CDMT00022"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><times/><ci> k6 </ci><ci> I_Smad_TGFb_TGFbR_P </ci></apply></math></kineticLaw></reaction><reaction metaid="r7" id="r7" name="r7" 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