<?xml version="1.0" encoding="utf-8"?><sedML xmlns:math="http://www.w3.org/1998/Math/MathML" xmlns="http://sed-ml.org/"  level="1" version="1">		<notes>		<p xmlns="http://www.w3.org/1999/xhtml">		Showing the oscillating behaviour of the Repressilator model		using deterministic and stochastic simulators		</p>		</notes>				<listOfSimulations>		<uniformTimeCourse id="simulation1" initialTime="0"			outputStartTime="0" outputEndTime="1000" numberOfPoints="1000">			<algorithm kisaoID="KISAO:0000088" />		</uniformTimeCourse>		<uniformTimeCourse id="simulation2" initialTime="0"			outputStartTime="0" outputEndTime="1000" numberOfPoints="1000">			<algorithm kisaoID="KISAO:0000027" />		</uniformTimeCourse>	</listOfSimulations>	<listOfModels>			<model id="model1" name="Repressilator-regular oscillations"			language="urn:sedml:language:sbml.level-2.version-3" source="urn:miriam:biomodels.db:BIOMD0000000012" >			<notes>		<p xmlns="http://www.w3.org/1999/xhtml">		This is the unmodified model.		</p>		</notes>		</model>		<model id="model2" name="Damped oscillations"			language="urn:sedml:language:sbml.level-2.version-3" source="model1">				<notes>		<p xmlns="http://www.w3.org/1999/xhtml">		This variant produces damped oscillations.		</p>		</notes>			<listOfChanges>				<changeAttribute					target="/sbml:sbml/sbml:model/sbml:listOfParameters/sbml:parameter[@name='tps_repr']/@value"					newValue="1.3e-5"></changeAttribute>				<changeAttribute					target="/sbml:sbml/sbml:model/sbml:listOfParameters/sbml:parameter[@name='tps_active']/@value"					newValue="0.013"></changeAttribute>			</listOfChanges>		</model>	</listOfModels>	<listOfTasks>		<task id="task1" name="Oscillation using a deterministic simulator"			modelReference="model1" simulationReference="simulation1" />		<task id="task2" name="Damped oscillations using a deterministic simulator"			modelReference="model2" simulationReference="simulation1" />	</listOfTasks>	<listOfDataGenerators>		<dataGenerator id="timeDG" name="Time">			<listOfVariables>				<variable id="Time" taskReference="task1" symbol="urn:sedml:symbol:time" />			</listOfVariables>			<math:math xmlns="http://www.w3.org/1998/Math/MathML">				<math:ci> Time </math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="LaCI" name="LaCI repressor">			<listOfVariables>				<variable id="v1" taskReference="task1"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PX']" />			</listOfVariables>			<math:math>				<math:ci>v1</math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="TetR" name="TetR repressor">			<listOfVariables>				<variable id="v2" taskReference="task1"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PY']" />			</listOfVariables>			<math:math>				<math:ci>v2</math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="CI" name="CI repressor">			<listOfVariables>				<variable id="v3" taskReference="task1"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PZ']" />			</listOfVariables>			<math:math>				<math:ci>v3</math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="timeDG2" name="Time">			<listOfVariables>				<variable id="time" taskReference="task2" symbol="urn:sedml:symbol:time" />			</listOfVariables>			<math:math>				<math:ci> time </math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="LaCIb" name="LaCI repressor">			<listOfVariables>				<variable id="v1b" taskReference="task2"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PX']" />			</listOfVariables>			<math:math>				<math:ci>v1b</math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="LacIbNormalizedDG" name=" NormalizedLaCI repressor">			<listOfVariables>				<variable id="LacIbNormalized" taskReference="task1"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PX']" />			</listOfVariables>			<math xmlns="http://www.w3.org/1998/Math/MathML">				<apply>					<divide />					<ci>LacIbNormalized</ci>					<apply>						<csymbol definitionURL="http://sed-ml.org/#max" encoding="text">max						</csymbol>						<ci>LacIbNormalized</ci>					</apply>				</apply>			</math>		</dataGenerator>		<dataGenerator id="TetRb" name="TetR repressor">			<listOfVariables>				<variable id="v2b" taskReference="task2"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PY']" />			</listOfVariables>			<math:math>				<math:ci>v2b</math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="TetRNormalizedDG" name=" Normalized TetR repressor">			<listOfVariables>				<variable id="TetRNormalized" taskReference="task1"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PY']" />			</listOfVariables>			<math xmlns="http://www.w3.org/1998/Math/MathML">				<apply>					<divide />					<ci>TetRNormalized</ci>					<apply>						<csymbol definitionURL="http://sed-ml.org/#max" encoding="text">max						</csymbol>						<ci>TetRNormalized</ci>					</apply>				</apply>			</math>		</dataGenerator>		<dataGenerator id="CIb" name="CI repressor">			<listOfVariables>				<variable id="v3b" taskReference="task2"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PZ']" />			</listOfVariables>			<math:math>				<math:ci>v3b</math:ci>			</math:math>		</dataGenerator>		<dataGenerator id="CIb_normalizedDG" name="Normalized CI repressor">			<listOfVariables>				<variable id="CIb_normalized" taskReference="task1"					target="/sbml:sbml/sbml:model/sbml:listOfSpecies/sbml:species[@id='PZ']" />			</listOfVariables>			<math xmlns="http://www.w3.org/1998/Math/MathML">				<apply>					<divide />					<ci>CIb_normalized</ci>					<apply>						<csymbol definitionURL="http://sed-ml.org/#max" encoding="text">max						</csymbol>						<ci>CIb_normalized</ci>					</apply>				</apply>			</math>		</dataGenerator>	</listOfDataGenerators>	<listOfOutputs>		<notes>		<p xmlns="http://www.w3.org/1999/xhtml">		This is the basic time-series of the unmodified model described in section 1.1.1 of the L1V1 specification document.		</p>		</notes>		<plot2D id="plot1_Basic" name="protein numbers per time point">			<listOfCurves>				<curve id="c1" logX="false" logY="false" xDataReference="timeDG"					yDataReference="LaCI" />				<curve id="c2" logX="false" logY="false" xDataReference="timeDG"					yDataReference="TetR" />				<curve id="c3" logX="false" logY="false" xDataReference="timeDG"					yDataReference="CI" />			</listOfCurves>		</plot2D>			<plot2D id="plot2_damped_oscillations"			name="protein numbers per time point - damped oscillations">				<notes>		<p xmlns="http://www.w3.org/1999/xhtml">		This is the damped oscillation plot described in section 1.1.2 of the L1V1 specification document.		</p>		</notes>			<listOfCurves>				<curve id="c4" logX="false" logY="false" xDataReference="timeDG2"					yDataReference="LaCIb" />				<curve id="c5" logX="false" logY="false" xDataReference="timeDG2"					yDataReference="TetRb" />				<curve id="c6" logX="false" logY="false" xDataReference="timeDG2"					yDataReference="CIb" />			</listOfCurves>		</plot2D>				<plot2D id="plot3_normalized_protein_levels" name="Normalized Plot">		<notes>		<p xmlns="http://www.w3.org/1999/xhtml">		This is the plot of normalized protein levels described in section 1.1.3 of the L1V1 specification document.		</p>		</notes>			<listOfCurves>				<curve id="c7" logX="false" logY="false" xDataReference="LacIbNormalizedDG"					yDataReference="TetRNormalizedDG" />				<curve id="c8" logX="false" logY="false" xDataReference="TetRNormalizedDG"					yDataReference="CIb_normalizedDG" />				<curve id="c9" logX="false" logY="false" xDataReference="CIb_normalizedDG"					yDataReference="LacIbNormalizedDG" />			</listOfCurves>		</plot2D>	</listOfOutputs></sedML>