Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum ER c5

STATE_TRANSITION_LEFT__CN-RIGHT__CN-_re1311
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1311 2073
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1311 2072
conversion direction: LEFT_TO_RIGHT
left: CN
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CN
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__G0-RIGHT__CDK5_DCTN5-_re93
type: Interaction
participant: G0 s85 sa135
participant: CDK5-DCTN5
xref: KNOWN TRANSITION OMITTED

STATE_TRANSITION_LEFT__CASP1-RIGHT__CASP1-_re624
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re624 1048
participant stoichiometry: PARTICIPANT STOICHIOMETRY re624 1049
conversion direction: LEFT_TO_RIGHT
left: CASP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CASP1
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re929 1543
type: Stoichiometry
physical entity: CHRN-AmyloidB
stoichiometric coefficient: 1.0

GLUT
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re929 1544
type: Stoichiometry
physical entity: DAG-IP3
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__metal_ligand_Cu-RIGHT__metal_ligand_Cu-_re487
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re487 805
participant stoichiometry: PARTICIPANT STOICHIOMETRY re487 804
conversion direction: LEFT_TO_RIGHT
left: metal ligand Cu s3224 csa125
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: metal ligand Cu s3223 csa126
xref: TRANSPORT

STATE_TRANSITION_LEFT__HS_-RIGHT__thiosulfate-_re459
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re459 759
participant stoichiometry: PARTICIPANT STOICHIOMETRY re459 760
conversion direction: LEFT_TO_RIGHT
left: HS-
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: thiosulfate s1332 sa996
xref: STATE TRANSITION

MMP3 s3082 sa2431 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MMP3 s3082 sa2431
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re280 429
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

IL12A
type: Protein

STOICHIOMETRY ID s3255 csa157
type: Stoichiometry
physical entity: GPCR-oxidative stress
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__TREM1_DAP12-RIGHT__phagocytosis-_re1216
type: Control
xref: STATE TRANSITION
controlled: phagocytosis s3689 sa2603
controller: TREM1-DAP12

PARTICIPANT STOICHIOMETRY re280 430
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

GLUT
type: Protein
feature: GLUT GLUT s3907 sa2826 Active
cellular location: neuron c1

PLCG
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1157 1800
type: Stoichiometry
physical entity: not written
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATG13-RIGHT__ATG13-_re749
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re749 1205
participant stoichiometry: PARTICIPANT STOICHIOMETRY re749 1204
conversion direction: LEFT_TO_RIGHT
left: ATG13
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ATG13
xref: STATE TRANSITION

ICAM1
type: DnaRegion
cellular location: nucleus c3

HSD17B10 s1060 sa768 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSD17B10
stoichiometric coefficient: 1.0

NCOR2
type: Protein

TLR9 s3754 sa2666 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLR9
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3294 csa260
type: Stoichiometry
physical entity: APP-APBA1
stoichiometric coefficient: 1.0

GLUT3 s3906 sa2824 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GLUT3
stoichiometric coefficient: 1.0

COX2
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re1083 1717
type: Stoichiometry
physical entity: LRP1-APOE-SDC2-Lipoprotein remnant
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CASP1-_NALP_-_IPAF-_ASC-RIGHT__inflammasome-_re1238
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1238 1955
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1238 1956
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1238 1953
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1238 1954
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1238 1952
conversion direction: LEFT_TO_RIGHT
left: ASC
left: NALP
left: CASP1
left: IPAF
interaction type: HETERODIMER_ASSOCIATION
right: inflammasome
xref: HETERODIMER ASSOCIATION

KNOWN_TRANSITION_OMITTED_LEFT__PE_GABARAPL2-RIGHT__autophagosome_formation-_re767
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: autophagosome formation
controller: PE GABARAPL2 s3249 csa203

PARTICIPANT STOICHIOMETRY re1083 1715
type: Stoichiometry
physical entity: APOE Lipoprotein remnant s3361 csa166
stoichiometric coefficient: 1.0

oxidative stress
type: Pathway

PARTICIPANT STOICHIOMETRY re1083 1716
type: Stoichiometry
physical entity: LRP1
stoichiometric coefficient: 1.0

Glucosamine 6 phosphate acetyl transferase s3914 sa2831 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Glucosamine 6 phosphate acetyl transferase s3914 sa2831
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1083 1714
type: Stoichiometry
physical entity: SDC2
stoichiometric coefficient: 1.0

C terminal of mutant PSEN s180 sa111 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C terminal of mutant PSEN s180 sa111
stoichiometric coefficient: 1.0

CAV1-TJ
type: Complex
component: TJ
component: CAV1 s1617 sa1242
cellular location: blood brain barrier BBB c22

PP1 s3846 sa2756 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PP1
stoichiometric coefficient: 1.0

Exendin4 s3926 sa2845 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Exendin4
stoichiometric coefficient: 1.0

re747 s2601 sa2060 1194
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__MTOR-RIGHT__MTOR-_re747
control type: INHIBITION
controller: AKT1S1

APC
type: Protein

TF s2922 sa2297 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TF
stoichiometric coefficient: 2.0

WNT7A
type: Protein
cellular location: default

UB s1716 sa574 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UB s1716 sa574
stoichiometric coefficient: 10.0

KNOWN_TRANSITION_OMITTED_LEFT__IRF-RIGHT__proinflammation-_re1228
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: proinflammation
controller: IRF

CD14
type: Protein

Lysosome c19
type: CellularLocationVocabulary
comment: _Lysosome

PARTICIPANT STOICHIOMETRY re1157 1801
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

MAPK1/3
type: Protein
cellular location: MAPK cascade c6

GABR
type: Protein
feature: GABR GABR s1080 sa784 Active

GRIA-glutamate
type: Complex
component: GRIA
component: glutamate s1206 sa1497
cellular location: neuron c1

glucocorticoid s2083 sa1602 STOICHIOMETRY ID
type: Stoichiometry
physical entity: glucocorticoid
stoichiometric coefficient: 1.0

sa2546_degraded
type: PhysicalEntity
cellular location: microglia c4

unknown s3687 sa2601 STOICHIOMETRY ID
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 2.0

ALOX s2693 sa2167 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ALOX
stoichiometric coefficient: 1.0

LRP5/6
type: Protein

GDI s2486 sa1954 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GDI
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__TNF-RIGHT__Neuronal_injury-_re12
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Neuronal injury
controller: TNF

MAPK13
type: Protein
cellular location: MAPK cascade c6

self drive danger signals
type: Pathway

MAPK8 s1910 sa829 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK8
stoichiometric coefficient: 1.0

MAP3K
type: Protein
cellular location: MAPK cascade c6

TNFA s3648 sa2558 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFA s3648 sa2558
stoichiometric coefficient: 1.0

GUCY1-NO
type: Complex
component: NO
component: GUCY1
cellular location: presynaptic terminal c11

C1Q
type: Protein
feature: C1Q C1Q s1282 sa945 Active

PKC s3911 sa2827 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__PGG2-RIGHT__PG-_unknown-_re111
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re111 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY re111 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re111 179
conversion direction: LEFT_TO_RIGHT
left: PGG2 s400 sa160
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: unknown
right: PG s78 sa157
xref: STATE TRANSITION

AICD
type: Protein
cellular location: default

FTH
type: Protein
cellular location: neuron c1

IKBK s1963 sa1450 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IKBK
stoichiometric coefficient: 1.0

ACTA1
type: DnaRegion
cellular location: neuron c1

ceramide
type: SmallMolecule
cellular location: neuron c1

sphingolipid s3936 sa2854 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sphingolipid s3936 sa2854
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3616 csa290
type: Stoichiometry
physical entity: RAGE-AGEs
stoichiometric coefficient: 1.0

NALP s3635 sa2540 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NALP
stoichiometric coefficient: 1.0

AmyloidB1-40
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re148 229
type: Stoichiometry
physical entity: cholesterol s87 sa190
stoichiometric coefficient: 1.0

SUOX
type: Protein
cellular location: mitochondria c7

O2
type: SmallMolecule
cellular location: inner membrane c8

STOICHIOMETRY ID s3870 csa318
type: Stoichiometry
physical entity: AGE-RAGE
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__B94-RIGHT__Inflammatory_signaling-_re1304
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammatory signaling
controller: B94 s3837 sa2746

PDK1
type: Protein
cellular location: neuron c1

APOE-AmyloidB
type: Complex
component: AmyloidB
component: APOE s470 sa315
cellular location: Blood c15

DAP12
type: Protein

STOICHIOMETRY ID s3189 csa239
type: Stoichiometry
physical entity: INPP5K-CSHL1-HDAC-NCOR2
stoichiometric coefficient: 1.0

MAPK13 s1804 sa1342 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK13
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re148 230
type: Stoichiometry
physical entity: 24-OH-Chol
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__PSPHL_APP_APBB1_DAB_ENAH_cytoskelton-RIGHT__neuronal_development-_re1041
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: neuronal development s1646 sa1260
controller: PSPHL APP APBB1 DAB ENAH cytoskelton s3251 csa154

TNF
type: RnaRegion
cellular location: nucleus c3

re314 s456 sa724 481
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__proMMP9-RIGHT__MMP9-_re314
control type: INHIBITION
controller: TIMP1

PARTICIPANT STOICHIOMETRY re1312 2077
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1312 2078
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

19S s3114 sa587 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 19S s3114 sa587
stoichiometric coefficient: 2.0

ATF6 s133 sa116 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATF6 s133 sa116
stoichiometric coefficient: 1.0

L Arg s1243 sa913 STOICHIOMETRY ID
type: Stoichiometry
physical entity: L Arg s1243 sa913
stoichiometric coefficient: 1.0

PG s78 sa157 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PG s78 sa157
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re412 693
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re412 692
type: Stoichiometry
physical entity: GTP s1259 sa926
stoichiometric coefficient: 1.0

DAP12 s3692 sa2605 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DAP12
stoichiometric coefficient: 1.0

PPARG-RXR-unkown PPARG ligand
type: Complex
component: unknown PPARG ligand
component: RXR s716 sa411
component: PPARG
cellular location: nucleus c3

KNOWN_TRANSITION_OMITTED_LEFT__Oligomeric_AmyloidB-RIGHT__cognitive_and_behavioral_abnormalities-_re641
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: cognitive and behavioral abnormalities
controller: Oligomeric AmyloidB

GEF s2499 sa1968 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GEF s2499 sa1968
stoichiometric coefficient: 1.0

posttranslational modification of APP and tau
type: Pathway

IL1B s3799 sa2711 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B s3799 sa2711
stoichiometric coefficient: 1.0

PAMPs s3740 sa2655 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PAMPs
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Glucose-RIGHT__Glyceraldehyde_P-_TIMP1-_re200
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re200 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY re200 280
participant stoichiometry: PARTICIPANT STOICHIOMETRY re200 282
conversion direction: LEFT_TO_RIGHT
left: Glucose s635 sa239
interaction type: KNOWN_TRANSITION_OMITTED
right: TIMP1
right: Glyceraldehyde-P
xref: KNOWN TRANSITION OMITTED

SRC
type: Protein
feature: SRC SRC s1401 sa1067 Active
cellular location: neuron c1

RAC1-GGPP
type: Complex
component: RAC1
component: GGPP
cellular location: neuron c1

STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re75
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 142
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 141
conversion direction: LEFT_TO_RIGHT
left: BAD
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: BAD
xref: STATE TRANSITION

CYC s71 sa130 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CYC
stoichiometric coefficient: 1.0

estrogen
type: SmallMolecule
cellular location: default

A2M
type: Protein

SRI s2412 sa1892 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRI
stoichiometric coefficient: 1.0

re1326 s3911 sa2828 2123
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_RIGHT__Insulin_IR-_re1326
control type: INHIBITION
controller: PKC

TRANSPORT_LEFT__GABA-RIGHT__GABA-_re336
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re336 531
participant stoichiometry: PARTICIPANT STOICHIOMETRY re336 530
conversion direction: LEFT_TO_RIGHT
left: GABA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: GABA
xref: TRANSPORT

HDAC s2548 sa2010 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HDAC
stoichiometric coefficient: 2.0

Farnesyl PP
type: SmallMolecule

KNOWN_TRANSITION_OMITTED_LEFT__LRP1_AmyloidB-RIGHT__Unknown_transportation-_re1018
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Unknown transportation
controller: LRP1-AmyloidB

mutant PSEN s1437 sa1094 STOICHIOMETRY ID
type: Stoichiometry
physical entity: mutant PSEN s1437 sa1094
stoichiometric coefficient: 4.0

STOICHIOMETRY ID s3310 csa270
type: Stoichiometry
physical entity: NFKB1-RELA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re837 1352
type: Stoichiometry
physical entity: Lanosterol
stoichiometric coefficient: 1.0

SRC
type: Protein
cellular location: neuron c1

PLG s1009 sa719 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLG
stoichiometric coefficient: 1.0

APOE s1887 sa1381 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re722 1166
type: Stoichiometry
physical entity: DAB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re837 1353
type: Stoichiometry
physical entity: 7-dehydrocholesterol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re722 1167
type: Stoichiometry
physical entity: DAB1
stoichiometric coefficient: 1.0

APOE
type: Protein
cellular location: sinusoid c28

Lipoprotein remnant s1888 sa1383 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Lipoprotein remnant
stoichiometric coefficient: 2.0

depolarization
type: Pathway

late endosome c18
type: CellularLocationVocabulary
comment: _late_endosome

lipoxin A4 s3679 sa2593 STOICHIOMETRY ID
type: Stoichiometry
physical entity: lipoxin A4 s3679 sa2593
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3739 csa305
type: Stoichiometry
physical entity: TLRs DAMPs s3739 csa305
stoichiometric coefficient: 1.0

WNT
type: Protein

PARTICIPANT STOICHIOMETRY re894 1471
type: Stoichiometry
physical entity: AKT1S1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re894 1472
type: Stoichiometry
physical entity: AKT1S1
stoichiometric coefficient: 1.0

TLR2
type: Protein
cellular location: microglia c4

Hexokinase
type: Protein
cellular location: neuron c1

IL1B s3625 sa2529 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

PPP2CA
type: Protein
cellular location: neuron c1

NFKB responsive genes s1003 sa713 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKB responsive genes
stoichiometric coefficient: 3.0

STATE_TRANSITION_LEFT__MIF-RIGHT__MIF-_re1131
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1131 1777
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1131 1776
conversion direction: LEFT_TO_RIGHT
left: MIF
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MIF
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__APC_AXIN_GSK3B_CTNNB1-_re596
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re596 1001
conversion direction: LEFT_TO_RIGHT
left: APC-AXIN-GSK3B-CTNNB1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
xref: STATE TRANSITION

VPS26A s22 sa4 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VPS26A
stoichiometric coefficient: 4.0

STATE_TRANSITION_LEFT__IRS2-RIGHT__IRS2-_re1325
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1325 2121
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1325 2120
conversion direction: LEFT_TO_RIGHT
left: IRS2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IRS2
xref: STATE TRANSITION

Acetate s618 sa222 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Acetate
stoichiometric coefficient: 1.0

Cu s1399 sa1064 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Cu s1399 sa1064
stoichiometric coefficient: 1.0

RHOA
type: Protein

PARTICIPANT STOICHIOMETRY re629 1059
type: Stoichiometry
physical entity: MAP2K7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re629 1058
type: Stoichiometry
physical entity: MAP2K7
stoichiometric coefficient: 1.0

ARL4C
type: Protein
feature: ARL4C ARL4C s2808 sa1907 Active
cellular location: neuron c1

TRANSPORT_LEFT__superoxide_anion-RIGHT__superoxide_anion-_re966
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re966 1586
participant stoichiometry: PARTICIPANT STOICHIOMETRY re966 1585
conversion direction: LEFT_TO_RIGHT
left: superoxide anion
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: superoxide anion
xref: TRANSPORT

FMR1 s1464 sa1121 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FMR1 s1464 sa1121
stoichiometric coefficient: 1.0

succinate
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1122 1764
type: Stoichiometry
physical entity: Unknown receptor Oligomeric AmyloicB s3317 csa280
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1122 1763
type: Stoichiometry
physical entity: Unknown receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1149 1795
type: Stoichiometry
physical entity: ceramide-1-P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1141 1788
type: Stoichiometry
physical entity: phosphatidylcholine s3566 sa2472
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1149 1794
type: Stoichiometry
physical entity: ceramide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1141 1789
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

SDC2
type: Protein

STOICHIOMETRY ID s3759 csa307
type: Stoichiometry
physical entity: TREM2 unknown protein s3759 csa307
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re917 1523
type: Stoichiometry
physical entity: PRKG1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re917 1524
type: Stoichiometry
physical entity: PRKG1
stoichiometric coefficient: 1.0

AA s403 sa159 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 2.0

sa585 degraded s865 sa588 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sa585_degraded
stoichiometric coefficient: 1.0

APPBP1
type: Protein
cellular location: neuron c1

PSEN s2480 sa1942 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSEN
stoichiometric coefficient: 2.0

APP
type: Protein
feature: APP APP s3655 sa2843 Active
cellular location: neuron c1

RAGE s3872 sa2789 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RAGE s3872 sa2789
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__N_APP-_TNFRSF21-RIGHT__TNFRSF21_N_APP-_re136
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re136 210
participant stoichiometry: PARTICIPANT STOICHIOMETRY re136 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re136 208
conversion direction: LEFT_TO_RIGHT
left: TNFRSF21
left: N-APP
interaction type: HETERODIMER_ASSOCIATION
right: TNFRSF21 N APP s3330 csa27
spontaneous: true
xref: HETERODIMER ASSOCIATION

Oligomeric AmyloidB
type: Protein

APAF1
type: Protein
feature: APAF1 APAF1 s615 sa409 Active

PARTICIPANT STOICHIOMETRY re258 376
type: Stoichiometry
physical entity: CTNNB1 s2840 sa461
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re258 377
type: Stoichiometry
physical entity: APC GSK3B AXIN s3259 csa53
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__GPCR_homolog-RIGHT__GPCR_homolog-_re17
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 18
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 19
conversion direction: LEFT_TO_RIGHT
left: GPCR homolog
interaction type: UNKNOWN_TRANSITION
right: GPCR homolog
xref: UNKNOWN TRANSITION

ROC1
type: Protein

UBE2 s896 sa616 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UBE2
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re17 18
type: Stoichiometry
physical entity: GPCR homolog
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 19
type: Stoichiometry
physical entity: GPCR homolog
stoichiometric coefficient: 1.0

ULK1
type: Protein
cellular location: neuron c1

LIPC s1849 sa1380 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LIPC s1849 sa1380
stoichiometric coefficient: 1.0

LRP1-AmyloidB
type: Complex
component: LRP1
component: AmyloidB
cellular location: Brain c26

UBE2M s786 sa508 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UBE2M
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__LRP1-_AmyloidB-RIGHT__LRP1_AmyloidB-_re540
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re540 911
participant stoichiometry: PARTICIPANT STOICHIOMETRY re540 912
participant stoichiometry: PARTICIPANT STOICHIOMETRY re540 910
conversion direction: LEFT_TO_RIGHT
left: AmyloidB s1546 sa1194
left: LRP1 s3498 sa1195
interaction type: HETERODIMER_ASSOCIATION
right: LRP1-AmyloidB
spontaneous: true
xref: HETERODIMER ASSOCIATION

unknown protein
type: PhysicalEntity
cellular location: neuron c1

TLR8 s3773 sa2679 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLR8
stoichiometric coefficient: 1.0

NTF s2658 sa2118 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTF
stoichiometric coefficient: 1.0

Oligomeric AmyloidB
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re1110 1741
type: Stoichiometry
physical entity: SCAR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1110 1742
type: Stoichiometry
physical entity: SCAR-AmyloidB fibril
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1110 1740
type: Stoichiometry
physical entity: AmyloidB fibril s2665 sa2153
stoichiometric coefficient: 1.0

IL6R
type: Protein
cellular location: neuron c1

FDPS s1098 sa801 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FDPS
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__APPBP1-_APP-RIGHT__APPBP1_APP-_re20
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 28
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 29
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 30
conversion direction: LEFT_TO_RIGHT
left: APP
left: APPBP1
interaction type: HETERODIMER_ASSOCIATION
right: APPBP1 APP s3324 csa17
spontaneous: true
xref: HETERODIMER ASSOCIATION

E3 ubiquitin-ligase
type: Complex
component: SKP1 s794 sa513
component: FBXO s798 sa514
component: CUL
component: ROC1
cellular location: neuron c1

TNF
type: Protein
feature: TNF TNF s2765 sa2234 Active
cellular location: blood brain barrier BBB c22

STOICHIOMETRY ID s3260 csa214
type: Stoichiometry
physical entity: NTRK3-NTF
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__HRK-RIGHT__HRK-_re632
type: TemplateReaction
participant: HRK
participant: HRK s1906 sa1428
product: HRK
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

STATE_TRANSITION_LEFT__PTEN-RIGHT__PTEN-_re830
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re830 1338
participant stoichiometry: PARTICIPANT STOICHIOMETRY re830 1337
conversion direction: LEFT_TO_RIGHT
left: PTEN
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PTEN
xref: STATE TRANSITION

inner membrane c8
type: CellularLocationVocabulary
comment: _inner_membrane

TLRs s3718 sa2627 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLRs
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__IL1B-RIGHT__activate_astrocyte-_re1182
type: Control
xref: STATE TRANSITION
controlled: activate astrocyte
controller: IL1B

Cu
type: SmallMolecule

KNOWN_TRANSITION_OMITTED_LEFT__Unknown_TF-RIGHT__dedifferentiation-_re988
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: dedifferentiation
controller: Unknown TF

TNF
type: Protein
cellular location: blood brain barrier BBB c22

RARA s1693 sa412 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RARA s1693 sa412
stoichiometric coefficient: 2.0

AKT1
type: Protein
feature: AKT1 AKT1 s2927 sa2301 rs2
feature: AKT1 AKT1 s2927 sa2301 Active
feature: AKT1 AKT1 s2927 sa2301 rs1
cellular location: neuron c1

SFK s2091 sa1613 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SFK
stoichiometric coefficient: 1.0

ZAP70 s2454 sa1923 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ZAP70
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re930 1546
type: Stoichiometry
physical entity: ATP2 s3524 sa2125
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re930 1547
type: Stoichiometry
physical entity: ATP2 s3524 sa2126
stoichiometric coefficient: 1.0

Heme A s1104 sa808 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Heme A s1104 sa808
stoichiometric coefficient: 1.0

MAPT s151 sa91 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPT s151 sa91
stoichiometric coefficient: 10.0

PPARA
type: Protein

fibrillary AmyloidB s1921 sa1444 STOICHIOMETRY ID
type: Stoichiometry
physical entity: fibrillary AmyloidB
stoichiometric coefficient: 5.0

HETERODIMER_ASSOCIATION_LEFT__ULK1-_ATG13-_ATG11-_ATG17-RIGHT__ATG13_ATG11_ULK1_ATG17-_re750
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re750 1206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re750 1208
participant stoichiometry: PARTICIPANT STOICHIOMETRY re750 1207
participant stoichiometry: PARTICIPANT STOICHIOMETRY re750 1209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re750 1210
conversion direction: LEFT_TO_RIGHT
left: ULK1
left: ATG17
left: ATG13
left: ATG11
interaction type: HETERODIMER_ASSOCIATION
right: ATG13-ATG11-ULK1-ATG17
spontaneous: true
xref: HETERODIMER ASSOCIATION

APP
type: Protein
cellular location: neuron c1

TTR
type: Protein
cellular location: Blood c15

PARTICIPANT STOICHIOMETRY re336 531
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re336 530
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re403 669
type: Stoichiometry
physical entity: CALM
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PSEN-RIGHT__PSEN-_re860
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re860 1400
participant stoichiometry: PARTICIPANT STOICHIOMETRY re860 1401
conversion direction: LEFT_TO_RIGHT
left: PSEN
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PSEN
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__APP_APBB1-RIGHT__APBB1_AICD-_unknown-_re309
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re309 468
participant stoichiometry: PARTICIPANT STOICHIOMETRY re309 469
participant stoichiometry: PARTICIPANT STOICHIOMETRY re309 470
conversion direction: LEFT_TO_RIGHT
left: APP-APBB1
interaction type: KNOWN_TRANSITION_OMITTED
right: APBB1-AICD
right: unknown
xref: KNOWN TRANSITION OMITTED

RAGE-AGEs
type: Complex
component: RAGE
component: AGEs
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re39 67
type: Stoichiometry
physical entity: CAPN s3447 sa5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re39 68
type: Stoichiometry
physical entity: CAPN s3447 sa6
stoichiometric coefficient: 1.0

Axon pruning, Neuronal culling
type: Pathway

TNF-TNFRSF1A-TRADD-TRAF2-RIP
type: Complex
component: TRADD
component: TRAF2
component: TNF
component: RIP s1945 sa1461
component: TNFRSF1A
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1118 1747
type: Stoichiometry
physical entity: Unknown receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1118 1748
type: Stoichiometry
physical entity: Unknown receptor Oligomeric AmyloicB s3317 csa280
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1118 1746
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

O2
type: SmallMolecule
cellular location: default

AmyloidB deposit
type: Pathway

CLU s1569 sa1209 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CLU
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re403 670
type: Stoichiometry
physical entity: Ca2 PLUS s1384 sa1053
stoichiometric coefficient: 1.0

Hydrolysis s3831 sa2740 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Hydrolysis s3831 sa2740
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re403 671
type: Stoichiometry
physical entity: CALM Ca2 PLUS s3214 csa116
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1175 1853
type: Stoichiometry
physical entity: speck-like protein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1175 1854
type: Stoichiometry
physical entity: speck-like protein
stoichiometric coefficient: 1.0

CDC42
type: Protein

Lipid raft c32
type: CellularLocationVocabulary
comment: _Lipid_raft

PARTICIPANT STOICHIOMETRY re627 1053
type: Stoichiometry
physical entity: MAP3K9/10/11
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re627 1052
type: Stoichiometry
physical entity: MAP3K9 10 11 s2882 sa1418
stoichiometric coefficient: 1.0

PSEN
type: Protein
cellular location: endoplasmic reticulum ER c5

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_NGFR-RIGHT__NGFR_AmyloidB-_re383
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re383 637
participant stoichiometry: PARTICIPANT STOICHIOMETRY re383 638
participant stoichiometry: PARTICIPANT STOICHIOMETRY re383 639
conversion direction: LEFT_TO_RIGHT
left: NGFR
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: NGFR AmyloidB s3199 csa111
spontaneous: true
xref: HETERODIMER ASSOCIATION

STOICHIOMETRY ID s3670 csa292
type: Stoichiometry
physical entity: IL4-IL4R
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3930 csa324
type: Stoichiometry
physical entity: G Secretase s3930 csa324
stoichiometric coefficient: 1.0

RAC s1904 sa1426 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RAC
stoichiometric coefficient: 1.0

NALP3 s3721 sa2631 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NALP3 s3721 sa2631
stoichiometric coefficient: 1.0

gro-LEF1-HDAC-TCF
type: Complex
component: gro s1755 sa1290
component: TCF
component: LEF1
component: HDAC s10 sa2026
cellular location: nucleus c3

ATG7
type: Protein
feature: ATG7 ATG7 s2222 sa1722 Active

Ubiquinol s3155 sa284 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Ubiquinol
stoichiometric coefficient: 2.0

PUFA s2358 sa1841 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PUFA
stoichiometric coefficient: 1.0

Neurofibrillary tangles(NFTs)
type: Pathway

STATE_TRANSITION_LEFT__FTH_ACO1_IREB2_Fe-RIGHT__Fe-_FTH_ACO1_IREB2-_re513
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re513 840
participant stoichiometry: PARTICIPANT STOICHIOMETRY re513 841
participant stoichiometry: PARTICIPANT STOICHIOMETRY re513 842
conversion direction: LEFT_TO_RIGHT
left: FTH-ACO1-IREB2-Fe
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FTH-ACO1-IREB2
right: Fe
xref: STATE TRANSITION

UBA1
type: Protein
feature: UBA1 UBA1 s933 sa651 rs1
cellular location: neuron c1

UBA3 s2805 sa503 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UBA3
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re1270
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1270 2012
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1270 2011
conversion direction: LEFT_TO_RIGHT
left: K+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: K+
xref: TRANSPORT

INPP5K
type: Protein
cellular location: nucleus c3

A2M
type: Protein
cellular location: default

BID s43 sa26 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BID
stoichiometric coefficient: 1.0

NTF
type: SmallMolecule
cellular location: default

UBE2
type: Protein

P2X7-ATP
type: Complex
component: P2X7 s3610 sa2512
component: ATP
cellular location: microglia c4

UNKNOWN_INHIBITION_LEFT__NPD1-RIGHT__Inflammatory_signaling-_re1354
type: Control
xref: UNKNOWN INHIBITION
controlled: Inflammatory signaling
controller: NPD1

PARTICIPANT STOICHIOMETRY re700 1135
type: Stoichiometry
physical entity: RHOA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re700 1134
type: Stoichiometry
physical entity: RHOA
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PRNP-RIGHT__SolublePRNP-_re358
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re358 581
participant stoichiometry: PARTICIPANT STOICHIOMETRY re358 582
conversion direction: LEFT_TO_RIGHT
left: PRNP s507 sa185
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: SolublePRNP
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__cGMP-RIGHT__glutamate-_re392
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re392 646
participant stoichiometry: PARTICIPANT STOICHIOMETRY re392 647
conversion direction: LEFT_TO_RIGHT
left: cGMP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: glutamate
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__PAMPs-RIGHT__NALP1-_re1268
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1268 2006
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1268 2005
conversion direction: LEFT_TO_RIGHT
left: PAMPs
interaction type: KNOWN_TRANSITION_OMITTED
right: NALP1
xref: KNOWN TRANSITION OMITTED

IPAF
type: Protein
feature: IPAF IPAF s3725 sa2637 Active
cellular location: microglia c4

LAG3
type: Protein
cellular location: nucleus c3

IL1B
type: Protein
cellular location: microglia c4

KNOWN_TRANSITION_OMITTED_LEFT__Generation_of_reactive_oxygen_species-RIGHT__DNA_damage-_re122
type: Interaction
participant: Generation of reactive oxygen species
participant: DNA damage
xref: KNOWN TRANSITION OMITTED

PDE5A
type: Protein
cellular location: postsynaptic density c12

CDK4 s272 sa350 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDK4
stoichiometric coefficient: 1.0

unknown
type: Protein

PARTICIPANT STOICHIOMETRY re617 1037
type: Stoichiometry
physical entity: LDLR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re617 1038
type: Stoichiometry
physical entity: APOE Lipoprotein remnant s3361 csa166
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re617 1039
type: Stoichiometry
physical entity: LDLR-APOE-Lipoprotein remnant
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PGK-RIGHT__PGK-_re202
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re202 289
participant stoichiometry: PARTICIPANT STOICHIOMETRY re202 288
conversion direction: LEFT_TO_RIGHT
left: PGK
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PGK s3488 sa250
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re343 546
type: Stoichiometry
physical entity: Mevalonate 5 phosphate s1088 sa792
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re343 547
type: Stoichiometry
physical entity: Mevalonate PP
stoichiometric coefficient: 1.0

PPARG
type: Protein

PPP3 s42 sa1910 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPP3
stoichiometric coefficient: 1.0

NTRK2
type: Protein
feature: NTRK2 NTRK2 s2595 sa1803 Active

Farnesyl PP
type: SmallMolecule
cellular location: neuron c1

superoxide anion
type: SmallMolecule
cellular location: neuron c1

SMPD s2348 sa1830 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SMPD
stoichiometric coefficient: 1.0

FMR1
type: Protein

PARTICIPANT STOICHIOMETRY re247 353
type: Stoichiometry
physical entity: APC-AXIN-GSK3B-CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re203 290
type: Stoichiometry
physical entity: pyruvate s653 sa251
stoichiometric coefficient: 1.0

AP1
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re203 291
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

GTPase
type: Protein

PARTICIPANT STOICHIOMETRY re49 101
type: Stoichiometry
physical entity: superoxide s2357 sa1840
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__sAPPA-_Unknown_receptor-RIGHT__unknown_receptor_sAPPA-_re915
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re915 1518
participant stoichiometry: PARTICIPANT STOICHIOMETRY re915 1516
participant stoichiometry: PARTICIPANT STOICHIOMETRY re915 1517
conversion direction: LEFT_TO_RIGHT
left: sAPPA
left: Unknown receptor
interaction type: HETERODIMER_ASSOCIATION
right: unknown receptor-sAPPA
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re49 103
type: Stoichiometry
physical entity: peroxynitrite (ONOO-)
stoichiometric coefficient: 1.0

PORC
type: Protein
cellular location: ER c30

PARTICIPANT STOICHIOMETRY re49 102
type: Stoichiometry
physical entity: NO s159 sa97
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re750 1206
type: Stoichiometry
physical entity: ULK1
stoichiometric coefficient: 1.0

acetylcholine
type: SmallMolecule
cellular location: neuron c1

TRANSCRIPTION_LEFT__PPARG-RIGHT__PPARG-_re711
type: TemplateReaction
participant: PPARG s2071 sa1589
participant: PPARG
product: PPARG s2071 sa1589
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re750 1208
type: Stoichiometry
physical entity: ATG11
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__HS_-RIGHT__thiosulfate-_re477
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re477 771
participant stoichiometry: PARTICIPANT STOICHIOMETRY re477 772
conversion direction: LEFT_TO_RIGHT
left: HS-
interaction type: HETERODIMER_ASSOCIATION
right: thiosulfate
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re750 1207
type: Stoichiometry
physical entity: ATG13
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re750 1209
type: Stoichiometry
physical entity: ATG17
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__IDE-RIGHT__IDE-_re1323
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1323 2115
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1323 2116
conversion direction: LEFT_TO_RIGHT
left: IDE
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: IDE
xref: TRANSPORT

intestinal epithelium cell c27
type: CellularLocationVocabulary
comment: _intestinal_epithelium_cell

GABA
type: SmallMolecule

STATE_TRANSITION_LEFT__GSH-RIGHT__GSSG-_re964
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re964 1581
participant stoichiometry: PARTICIPANT STOICHIOMETRY re964 1580
conversion direction: LEFT_TO_RIGHT
left: GSH
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GSSG
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1075 1693
type: Stoichiometry
physical entity: CTNNB1-GSK3B-PRKA-PSEN
stoichiometric coefficient: 1.0

EIF4EBP1
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1075 1692
type: Stoichiometry
physical entity: PSEN
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CTNNB1-_APC_GSK3B_AXIN-_re258
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re258 376
participant stoichiometry: PARTICIPANT STOICHIOMETRY re258 377
conversion direction: LEFT_TO_RIGHT
left: APC GSK3B AXIN s3259 csa53
left: CTNNB1 s2840 sa461
interaction type: HETERODIMER_ASSOCIATION
xref: HETERODIMER ASSOCIATION

KREMEN2
type: Protein
cellular location: neuron c1

CTH s1339 sa1003 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CTH
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3203 csa178
type: Stoichiometry
physical entity: glutamate-GRIN
stoichiometric coefficient: 1.0

TNFA
type: RnaRegion
cellular location: astrocyte c2

TLR2
type: Protein

PARTICIPANT STOICHIOMETRY re327 504
type: Stoichiometry
physical entity: ALLOP s2869 sa2274
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re327 503
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__NLRs-RIGHT__inflammation-_re1233
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: inflammation
controller: NLRs

PARTICIPANT STOICHIOMETRY re1283 2025
type: Stoichiometry
physical entity: HMGB1 s3807 sa2716
stoichiometric coefficient: 1.0

TST s1365 sa1031 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TST
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__TSC-RIGHT__TSC-_re890
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re890 1463
participant stoichiometry: PARTICIPANT STOICHIOMETRY re890 1462
conversion direction: LEFT_TO_RIGHT
left: TSC
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TSC
xref: STATE TRANSITION

Ca2+ increase
type: Pathway

re747 s2607 sa2071 1196
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__MTOR-RIGHT__MTOR-_re747
control type: INHIBITION
controller: PCSK1 s2607 sa2071

PARTICIPANT STOICHIOMETRY re750 1210
type: Stoichiometry
physical entity: ATG13-ATG11-ULK1-ATG17
stoichiometric coefficient: 1.0

PPARA ligands s3042 sa2390 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARA ligands
stoichiometric coefficient: 1.0

re211 s904 sa627 299
type: Control
xref: INHIBITION
controlled: TRANSPORT LEFT acetoacetate-RIGHT acetoacetate- re211
control type: INHIBITION
controller: estrogen

STOICHIOMETRY ID s3280 csa224
type: Stoichiometry
physical entity: KCNIP3-mutant PSEN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1209 1904
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1209 1905
type: Stoichiometry
physical entity: sa2546_degraded
stoichiometric coefficient: 1.0

PTGS2 s3466 sa2249 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PTGS2
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3226 csa127
type: Stoichiometry
physical entity: EGF-EGFR
stoichiometric coefficient: 2.0

STK11 s3462 sa2065 STOICHIOMETRY ID
type: Stoichiometry
physical entity: STK11
stoichiometric coefficient: 1.0

PPARG
type: Protein
cellular location: neuron c1

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re1283 2027
type: Stoichiometry
physical entity: RAGE HMGB1 s3805 csa311
stoichiometric coefficient: 1.0

sphingosine
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1283 2026
type: Stoichiometry
physical entity: RAGE
stoichiometric coefficient: 1.0

Uridine di-phospho-N-acetylglucosamine pyrophosphorylase
type: Protein
cellular location: neuron c1

INHIBITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re511 837
type: Stoichiometry
physical entity: APP PCBP2 PCBP1 FMR1 60S 40S s3232 csa135
stoichiometric coefficient: 1.0

TF
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re511 836
type: Stoichiometry
physical entity: ACO1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re511 833
type: Stoichiometry
physical entity: PCBP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re511 832
type: Stoichiometry
physical entity: FMR1 s1464 sa1121
stoichiometric coefficient: 1.0

C8 s372 sa362 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C8
stoichiometric coefficient: 2.0

STOICHIOMETRY ID s3279 csa223
type: Stoichiometry
physical entity: CAPN2-mutant PSEN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re511 835
type: Stoichiometry
physical entity: PCBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re511 834
type: Stoichiometry
physical entity: APP ACO1 s3233 csa134
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re511 831
type: Stoichiometry
physical entity: 40S
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re511 830
type: Stoichiometry
physical entity: 60S s1500 sa2328
stoichiometric coefficient: 1.0

GlcNH26P
type: SmallMolecule
cellular location: neuron c1

ERN1 s183 sa114 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ERN1
stoichiometric coefficient: 1.0

NOD2 s3730 sa2644 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOD2
stoichiometric coefficient: 1.0

ABCA1
type: Protein
cellular location: astrocyte c2

XBP1
type: Protein
feature: XBP1 XBP1 s2472 sa1935 Active
cellular location: endoplasmic reticulum ER c5

CDC42
type: Protein
feature: CDC42 CDC42 s1899 sa1421 Active
feature: CDC42 CDC42 s1899 sa1421 rs1
cellular location: MAPK cascade c6

TNF
type: Protein
feature: TNF TNF s3471 sa2454 Active
cellular location: neuron c1

cGMP
type: SmallMolecule
cellular location: presynaptic terminal c11

NOS s1241 sa912 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOS s1241 sa912
stoichiometric coefficient: 1.0

NOTCH ectodomain-Delta
type: Complex
component: Delta
component: NOTCH ectodomain
cellular location: neuron c1

LT s81 sa158 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LT s81 sa158
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3268 csa183
type: Stoichiometry
physical entity: WIF-WNT
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3312 csa254
type: Stoichiometry
physical entity: LBP-1-TFCP2-PCBP2
stoichiometric coefficient: 1.0

XBP1
type: Protein
cellular location: endoplasmic reticulum ER c5

PARTICIPANT STOICHIOMETRY re16 15
type: Stoichiometry
physical entity: TNFRSF1A s2237 sa67
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 16
type: Stoichiometry
physical entity: TNFRSF1A s2237 sa63
stoichiometric coefficient: 1.0

C8 s432 sa10 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C8
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__IL6-_IL6R-RIGHT__IL6_IL6R-_re782
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re782 1258
participant stoichiometry: PARTICIPANT STOICHIOMETRY re782 1259
participant stoichiometry: PARTICIPANT STOICHIOMETRY re782 1260
conversion direction: LEFT_TO_RIGHT
left: IL6
left: IL6R
interaction type: HETERODIMER_ASSOCIATION
right: IL6-IL6R
spontaneous: true
xref: HETERODIMER ASSOCIATION

TNFRSF1A
type: Protein

PPARG
type: DnaRegion
cellular location: nucleus c3

C2orf28
type: Protein
cellular location: neuron c1

MPST
type: Protein
cellular location: mitochondria c7

HSP60 s3767 sa2676 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSP60
stoichiometric coefficient: 1.0

TNF
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__Farnesyl_PP-RIGHT__Squalene-_re348
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re348 564
participant stoichiometry: PARTICIPANT STOICHIOMETRY re348 563
conversion direction: LEFT_TO_RIGHT
left: Farnesyl PP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Squalene s1100 sa804
xref: STATE TRANSITION

TSC
type: Protein
feature: TSC TSC s3458 sa2052 Active
cellular location: neuron c1

IRF
type: Protein
feature: IRF IRF s3717 sa2625 Active
cellular location: microglia c4

unknown
type: PhysicalEntity
cellular location: neuron c1

glutamate
type: SmallMolecule
cellular location: default

STOICHIOMETRY ID s3291 csa257
type: Stoichiometry
physical entity: APP MAPK8IP1 s3291 csa257
stoichiometric coefficient: 1.0

ABCA1
type: Protein
feature: ABCA1 ABCA1 s3163 sa201 Active
cellular location: astrocyte c2

VCAM1
type: Protein
cellular location: blood brain barrier BBB c22

re1254 s3759 csa307 1992
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSLATION_LEFT__cytokine-RIGHT__cytokine-_re1254
control type: INHIBITION
controller: TREM2 unknown protein s3759 csa307

H+
type: SmallMolecule
cellular location: mitochondria c7

STOICHIOMETRY ID s1537 csa145
type: Stoichiometry
physical entity: vesicle transport s1537 csa145
stoichiometric coefficient: 1.0

metal ligand
type: SmallMolecule

STATE_TRANSITION_LEFT__TNFA-RIGHT__TNFA-_re1320
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1320 2106
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1320 2107
conversion direction: LEFT_TO_RIGHT
left: TNFA s3864 sa2783
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNFA
xref: STATE TRANSITION

TSC
type: Protein
cellular location: neuron c1

IL1 s3794 sa2706 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1 s3794 sa2706
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re316 489
type: Stoichiometry
physical entity: s1016
stoichiometric coefficient: 1.0

IRF
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re316 488
type: Stoichiometry
physical entity: NGF
stoichiometric coefficient: 1.0

TNFRSF21 s505 sa384 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFRSF21
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__JUN-RIGHT__JUN-_re631
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re631 1061
participant stoichiometry: PARTICIPANT STOICHIOMETRY re631 1062
conversion direction: LEFT_TO_RIGHT
left: JUN
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: JUN s2830 sa1422
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1003 1632
type: Stoichiometry
physical entity: CASP2 s1761 sa1302
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__protein_phosphorylation-RIGHT__synaptic_plasticity-_re417
type: Interaction
participant: synaptic plasticity
participant: protein phosphorylation
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re1003 1633
type: Stoichiometry
physical entity: CASP2
stoichiometric coefficient: 1.0

CD93-C1Q-AmyloidB1-42
type: Complex
component: AmyloidB1-42
component: C1Q
component: CD93
cellular location: default

NF-KB responsive
type: Pathway

HETERODIMER_ASSOCIATION_LEFT__ADRBK1-_PEBP1-RIGHT__ADRBK1_PEBP1-_re743
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re743 1183
participant stoichiometry: PARTICIPANT STOICHIOMETRY re743 1185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re743 1184
conversion direction: LEFT_TO_RIGHT
left: ADRBK1
left: PEBP1
interaction type: HETERODIMER_ASSOCIATION
right: ADRBK1-PEBP1
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re1244 1974
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 1.0

MVD s1093 sa797 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MVD s1093 sa797
stoichiometric coefficient: 1.0

ATG16
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1244 1973
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

MVK s1089 sa793 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MVK
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__TNF-RIGHT__TNF-_re780
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re780 1254
participant stoichiometry: PARTICIPANT STOICHIOMETRY re780 1253
conversion direction: LEFT_TO_RIGHT
left: TNF s2777 sa2241
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: TNF
xref: TRANSPORT

TUB s929 sa648 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TUB s929 sa648
stoichiometric coefficient: 1.0

GABR s1080 sa784 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GABR
stoichiometric coefficient: 1.0

mutant APP s1918 sa1440 STOICHIOMETRY ID
type: Stoichiometry
physical entity: mutant APP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__EGF-_EGFR-RIGHT__EGF_EGFR-_re490
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re490 811
participant stoichiometry: PARTICIPANT STOICHIOMETRY re490 810
participant stoichiometry: PARTICIPANT STOICHIOMETRY re490 809
conversion direction: LEFT_TO_RIGHT
left: EGFR s1403 sa1068
left: EGF s1404 sa1069
interaction type: HETERODIMER_ASSOCIATION
right: EGF-EGFR
spontaneous: true
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__UDP_GlcNAc-_MAPT_-RIGHT__O_GlcNAcylated_MAPT-_UDP-_re1341
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1341 2167
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1341 2169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1341 2168
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1341 2170
conversion direction: LEFT_TO_RIGHT
left: UDP-GlcNAc
left: MAPT s3448 sa85
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: UDP s3919 sa2836
right: O-GlcNAcylated MAPT
xref: STATE TRANSITION

sulfate s1371 sa1037 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sulfate
stoichiometric coefficient: 1.0

endoplasmic reticulum ER c5
type: CellularLocationVocabulary
comment: _endoplasmic_reticulum_ER_

PKC
type: Protein
cellular location: neuron c1

ICAM1 s1643 sa1257 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ICAM1
stoichiometric coefficient: 1.0

AmyloidB1 40 s3939 sa2857 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB1-40
stoichiometric coefficient: 1.0

APP s1 sa32 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PDH
type: Protein
feature: PDH PDH s655 sa253 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re562 948
type: Stoichiometry
physical entity: CAV1-TJ
stoichiometric coefficient: 1.0

MPM 2 s927 sa646 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MPM-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re562 947
type: Stoichiometry
physical entity: TJ s1636 sa1233
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re562 946
type: Stoichiometry
physical entity: CAV1
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3184 csa241
type: Stoichiometry
physical entity: NICD LAG3 CSHL1 s3184 csa241
stoichiometric coefficient: 1.0

7-dehydrocholesterol
type: SmallMolecule
cellular location: neuron c1

AmyloidB clearance
type: Pathway

NEDD8 s827 sa510 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NEDD8 s827 sa510
stoichiometric coefficient: 4.0

KREMEN2 s1750 sa1284 STOICHIOMETRY ID
type: Stoichiometry
physical entity: KREMEN2
stoichiometric coefficient: 1.0

APP
type: Protein
feature: APP APP s2724 sa2196 rs1

iNOS
type: Protein
cellular location: astrocyte c2

PARTICIPANT STOICHIOMETRY re369 607
type: Stoichiometry
physical entity: PSPHL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re971 1594
type: Stoichiometry
physical entity: HNE
stoichiometric coefficient: 1.0

MAPT s146 sa86 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re369 608
type: Stoichiometry
physical entity: PSPHL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re971 1593
type: Stoichiometry
physical entity: LOO
stoichiometric coefficient: 1.0

DVL
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__CBS-RIGHT__CBS-_re486
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re486 803
participant stoichiometry: PARTICIPANT STOICHIOMETRY re486 802
conversion direction: LEFT_TO_RIGHT
left: CBS
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CBS
xref: STATE TRANSITION

inflammasome s3724 sa2635 STOICHIOMETRY ID
type: Stoichiometry
physical entity: inflammasome
stoichiometric coefficient: 1.0

CACNA1 s60 sa30 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CACNA1
stoichiometric coefficient: 1.0

GGPS1 s1103 sa807 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GGPS1 s1103 sa807
stoichiometric coefficient: 1.0

IL1B s3800 sa2712 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B s3800 sa2712
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re153 240
type: Stoichiometry
physical entity: ABCA1
stoichiometric coefficient: 1.0

APP-APBA1
type: Complex
component: APP
component: APBA1
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re153 241
type: Stoichiometry
physical entity: ABCA1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re279 422
type: Stoichiometry
physical entity: PDK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re279 423
type: Stoichiometry
physical entity: PDK1 s915 sa635
stoichiometric coefficient: 1.0

MPST s1337 sa1001 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MPST
stoichiometric coefficient: 1.0

Ca2 PLUS s1384 sa1053 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Ca2 PLUS s1384 sa1053
stoichiometric coefficient: 1.0

NO
type: SmallMolecule
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re376 625
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1256 1997
type: Stoichiometry
physical entity: TLR2-DAMPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1256 1996
type: Stoichiometry
physical entity: DAMPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re376 627
type: Stoichiometry
physical entity: AmyloidB-TTR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1256 1995
type: Stoichiometry
physical entity: TLR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re376 626
type: Stoichiometry
physical entity: TTR
stoichiometric coefficient: 1.0

sAPPB
type: Protein
cellular location: default

STOICHIOMETRY ID s3358 csa85
type: Stoichiometry
physical entity: UBE2-UB
stoichiometric coefficient: 1.0

postsynaptic density c12
type: CellularLocationVocabulary
comment: _postsynaptic_density

STATE_TRANSITION_LEFT__CYC-RIGHT__CYC-_Q-_re225
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re225 325
participant stoichiometry: PARTICIPANT STOICHIOMETRY re225 326
participant stoichiometry: PARTICIPANT STOICHIOMETRY re225 327
conversion direction: LEFT_TO_RIGHT
left: CYC s3169 sa298
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Q
right: CYC
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__GlcNH26P-RIGHT__GlcNAc6P-_re1336
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1336 2152
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1336 2151
conversion direction: LEFT_TO_RIGHT
left: GlcNH26P
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GlcNAc6P
xref: STATE TRANSITION

GDI
type: Protein
feature: GDI GDI s2486 sa1956 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1207 1897
type: Stoichiometry
physical entity: IL4R
stoichiometric coefficient: 1.0

FDFT1
type: Protein
cellular location: neuron c1

K PLUS s1380 sa1049 STOICHIOMETRY ID
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re1207 1899
type: Stoichiometry
physical entity: IL4-IL4R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1207 1898
type: Stoichiometry
physical entity: IL4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1242 1969
type: Stoichiometry
physical entity: DAMPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1242 1968
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_NALP-RIGHT__NALP_AmyloidB-_re1173
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1173 1843
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1173 1844
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1173 1842
conversion direction: LEFT_TO_RIGHT
left: AmyloidB
left: NALP
interaction type: HETERODIMER_ASSOCIATION
right: NALP-AmyloidB
spontaneous: true
xref: HETERODIMER ASSOCIATION

HETERODIMER_ASSOCIATION_LEFT__ABL-_APP_APBB1-RIGHT__APP_APBB1_ABL-_re975
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re975 1599
participant stoichiometry: PARTICIPANT STOICHIOMETRY re975 1598
participant stoichiometry: PARTICIPANT STOICHIOMETRY re975 1600
conversion direction: LEFT_TO_RIGHT
left: APP-APBB1
left: ABL s2722 sa2195
interaction type: HETERODIMER_ASSOCIATION
right: APP APBB1 ABL s3325 csa256
spontaneous: true
xref: HETERODIMER ASSOCIATION

SFRP-WNT
type: Complex
component: WNT
component: SFRP s2040 sa1553
cellular location: default

COX2 s3638 sa2544 STOICHIOMETRY ID
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

TNFB s3060 sa2414 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFB s3060 sa2414
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__EIF2AK3-RIGHT__EIF2AK3-_re851
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re851 1387
participant stoichiometry: PARTICIPANT STOICHIOMETRY re851 1388
conversion direction: LEFT_TO_RIGHT
left: EIF2AK3
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: EIF2AK3
xref: STATE TRANSITION

C1Q s1282 sa945 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C1Q
stoichiometric coefficient: 1.0

Mg2 PLUS s1387 sa1503 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 4.0

PARTICIPANT STOICHIOMETRY re1176 1857
type: Stoichiometry
physical entity: ROS s3621 sa2521
stoichiometric coefficient: 1.0

UBA3
type: Protein

PARTICIPANT STOICHIOMETRY re1242 1970
type: Stoichiometry
physical entity: TLR4-DAMPs
stoichiometric coefficient: 1.0

IL6 s3509 sa1751 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1176 1856
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

GDI
type: Protein
cellular location: neuron c1

ITAM
type: Complex
component: CD3Z complex
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re886 1453
type: Stoichiometry
physical entity: NICD s972 sa682
stoichiometric coefficient: 1.0

SRC s1401 sa1067 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PRIM1-PCLB-APEX1-POLD1
type: Complex
component: POLD1
component: PRIM1
component: replication origin
component: APEX1 s1678 sa406
component: POLB
cellular location: DNAreplification c9

HDAC-NCOR2
type: Complex
component: HDAC s10 sa2026
component: NCOR2
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re225 325
type: Stoichiometry
physical entity: CYC s3169 sa298
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re225 326
type: Stoichiometry
physical entity: CYC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re886 1454
type: Stoichiometry
physical entity: s49 s2552 sa2015
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re225 327
type: Stoichiometry
physical entity: Q
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re171 265
type: Stoichiometry
physical entity: APAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re171 264
type: Stoichiometry
physical entity: APAF1
stoichiometric coefficient: 1.0

sinusoid c28
type: CellularLocationVocabulary
comment: _sinusoid

re777 s3315 csa276 1245
type: Control
xref: INHIBITION
controlled: STATE TRANSITION LEFT IL6-RIGHT IL6- re777
control type: INHIBITION
controller: PPARA ligands-PPARA

Synaptic suppression
type: Pathway

IGF1R
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__MAPK14-RIGHT__MAPK14-_re602
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re602 1019
participant stoichiometry: PARTICIPANT STOICHIOMETRY re602 1018
conversion direction: LEFT_TO_RIGHT
left: MAPK14
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPK14
xref: STATE TRANSITION

LRP5/6
type: Protein
feature: LRP5 6 LRP5 6 s274 sa483 Active
feature: LRP5 6 LRP5 6 s274 sa483 rs1

KNOWN_TRANSITION_OMITTED_LEFT__APP_GAPDH-RIGHT__decreased_energy_production-_re164
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: decreased energy production s20 sa45
controller: APP GAPDH s3343 csa22

IGF1R s3106 sa1848 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IGF1R
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__unknown-RIGHT__ROS-_re1220
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1220 1930
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1220 1929
conversion direction: LEFT_TO_RIGHT
left: unknown
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ROS
xref: STATE TRANSITION

SET s1718 sa700 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SET
stoichiometric coefficient: 1.0

MMP
type: DnaRegion
cellular location: neuron c1

re636 s2927 sa2301 1070
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re636
control type: INHIBITION
controller: AKT1

CD14 s3748 sa2663 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD14
stoichiometric coefficient: 1.0

ATG11 s2175 sa1681 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG11 s2175 sa1681
stoichiometric coefficient: 1.0

re890 s2927 sa2301 1457
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__TSC-RIGHT__TSC-_re890
control type: INHIBITION
controller: AKT1

STOICHIOMETRY ID s3690 csa295
type: Stoichiometry
physical entity: TREM1-DAP12
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re538 909
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

FTH-ACO1-IREB2-Fe
type: Complex
component: ACO1 s1478 sa1132
component: FTH
component: Fe
component: IREB2
cellular location: neuron c1

MARCO s3662 sa2579 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MARCO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re331 520
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re331 521
type: Stoichiometry
physical entity: 5ADHP s2826 sa2261
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__IL1B-RIGHT__activate_microglia-_re1199
type: Control
xref: STATE TRANSITION
controlled: activate microglia s3633 sa2539
controller: IL1B

STOICHIOMETRY ID s3738 csa304
type: Stoichiometry
physical entity: TLRs-PAMPs
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3347 csa35
type: Stoichiometry
physical entity: APAF1-CASP9
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CHRM-_ACh-RIGHT__ACh_CHRM-_re322
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re322 495
participant stoichiometry: PARTICIPANT STOICHIOMETRY re322 496
participant stoichiometry: PARTICIPANT STOICHIOMETRY re322 497
conversion direction: LEFT_TO_RIGHT
left: ACh
left: CHRM
interaction type: HETERODIMER_ASSOCIATION
right: ACh-CHRM
spontaneous: true
xref: HETERODIMER ASSOCIATION

MAPK8
type: Protein
feature: MAPK8 MAPK8 s1911 sa830 rs1
feature: MAPK8 MAPK8 s1911 sa830 Active
cellular location: MAPK cascade c6

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB_A2M-RIGHT__Unknown_transportation-_re1030
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Unknown transportation
controller: AmyloidB-A2M

cytokines
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re538 908
type: Stoichiometry
physical entity: vesicle transport s1537 csa145
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3342 csa30
type: Stoichiometry
physical entity: APOE-cholesterol
stoichiometric coefficient: 1.0

AP1 s3649 sa2559 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

re245 s2066 sa1584 339
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__FZD_LRP5_6_CSNK1A1-_WNT-RIGHT__FZD_WNT_LRP5_6-_CSNK1A1-_re245
control type: INHIBITION
controller: Oligomeric AmyloidB

APOE s2761 sa2228 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

SFK
type: Protein
cellular location: neuron c1

PAMPs s3744 sa2659 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PAMPs
stoichiometric coefficient: 1.0

cytokines
type: Protein
feature: cytokines cytokines s3699 sa2613 Active
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re331 519
type: Stoichiometry
physical entity: NAD PLUS s1061 sa769
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re331 518
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__24_OH_Chol-RIGHT__sa286_degraded-_re154
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re154 243
participant stoichiometry: PARTICIPANT STOICHIOMETRY re154 242
conversion direction: LEFT_TO_RIGHT
left: 24-OH-Chol
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sa286_degraded
xref: STATE TRANSITION

SFK
type: Protein
feature: SFK SFK s2091 sa1613 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re290 446
type: Stoichiometry
physical entity: TUB s929 sa648
stoichiometric coefficient: 1.0

thiosulfate:thiol sulfurtransferase s1340 sa1004 STOICHIOMETRY ID
type: Stoichiometry
physical entity: thiosulfate:thiol sulfurtransferase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re290 445
type: Stoichiometry
physical entity: TUB
stoichiometric coefficient: 1.0

ACHE
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_ALB-RIGHT__AmyloidB_ALB-_re375
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re375 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY re375 623
participant stoichiometry: PARTICIPANT STOICHIOMETRY re375 624
conversion direction: LEFT_TO_RIGHT
left: ALB
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB-ALB
spontaneous: true
xref: HETERODIMER ASSOCIATION

IL1B
type: RnaRegion
cellular location: microglia c4

DMRT1
type: Protein
cellular location: neuron c1

inflammasome s3724 sa2636 STOICHIOMETRY ID
type: Stoichiometry
physical entity: inflammasome
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FDPS-RIGHT__FDPS-_re864
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re864 1412
participant stoichiometry: PARTICIPANT STOICHIOMETRY re864 1413
conversion direction: LEFT_TO_RIGHT
left: FDPS s1098 sa1949
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FDPS
xref: STATE TRANSITION

LRP
type: Protein
cellular location: BBB c25

mutant PSEN s1919 sa1441 STOICHIOMETRY ID
type: Stoichiometry
physical entity: mutant PSEN
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__APP-RIGHT__APP-_re128
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re128 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY re128 199
conversion direction: LEFT_TO_RIGHT
left: APP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APP
xref: STATE TRANSITION

ATG4 s2212 sa1719 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG4 s2212 sa1719
stoichiometric coefficient: 1.0

DVL s308 sa462 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DVL
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NFKBI-RIGHT__NFKBI-_re715
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re715 1152
participant stoichiometry: PARTICIPANT STOICHIOMETRY re715 1153
conversion direction: LEFT_TO_RIGHT
left: NFKBI
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NFKBI
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__endosome_lysosome-RIGHT__csa30_degraded-_re134
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re134 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re134 207
conversion direction: LEFT_TO_RIGHT
left: endosome lysosome s497 csa26
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: csa30_degraded
xref: STATE TRANSITION

PSPHL
type: Protein
cellular location: neuron c1

CHRN
type: Protein
cellular location: neuron c1

GSH
type: SmallMolecule
cellular location: neuron c1

succinyl-CoA
type: SmallMolecule
cellular location: neuron c1

Fe2+
type: SmallMolecule
cellular location: default

s2754 s2754 sa2222 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s2754
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1282 2023
type: Stoichiometry
physical entity: RAGE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1282 2024
type: Stoichiometry
physical entity: RAGE AmyloidB s3804 csa310
stoichiometric coefficient: 1.0

CDK5
type: Protein
feature: CDK5 CDK5 s134 sa327 Active

PARTICIPANT STOICHIOMETRY re581 972
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1282 2022
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re581 973
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PLCB
type: Protein
feature: PLCB PLCB s45 sa70 Active
cellular location: neuron c1

ST8SIA1 s2077 sa1596 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ST8SIA1 s2077 sa1596
stoichiometric coefficient: 1.0

ATG3 s2223 sa1724 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG3 s2223 sa1724
stoichiometric coefficient: 1.0

CSNK1A1 s1738 sa1277 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CSNK1A1
stoichiometric coefficient: 1.0

CCNE s3449 sa134 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CCNE
stoichiometric coefficient: 1.0

APOE-SDC2-LIPC-LPL-Lipoprotein remnant
type: Complex
component: LPL
component: LIPC
component: Lipoprotein remnant
component: SDC2
component: APOE s470 sa315
cellular location: sinusoid c28

PARTICIPANT STOICHIOMETRY re73 139
type: Stoichiometry
physical entity: CALM-Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re73 138
type: Stoichiometry
physical entity: CALM
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re73 137
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re726 1179
type: Stoichiometry
physical entity: LRP8-RELN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re726 1178
type: Stoichiometry
physical entity: RELN s2095 sa1618
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AA-RIGHT__oxyradical-_re1074
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1074 1691
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1074 1690
conversion direction: LEFT_TO_RIGHT
left: AA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: oxyradical
xref: STATE TRANSITION

ALLOP
type: SmallMolecule
cellular location: mitochondia c13

PARTICIPANT STOICHIOMETRY re726 1177
type: Stoichiometry
physical entity: LRP8
stoichiometric coefficient: 1.0

cytokine
type: DnaRegion
cellular location: microglia c4

cGMP s1258 sa925 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

thiosulfate:thiol sulfurtransferase
type: Protein
cellular location: neuron c1

15 LOX 1 s3829 sa2738 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 15-LOX-1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GPP-RIGHT__Farnesyl_PP-_re347
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re347 559
participant stoichiometry: PARTICIPANT STOICHIOMETRY re347 560
conversion direction: LEFT_TO_RIGHT
left: GPP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Farnesyl PP
xref: STATE TRANSITION

ROS
type: SmallMolecule
cellular location: blood brain barrier BBB c22

PARTICIPANT STOICHIOMETRY re915 1518
type: Stoichiometry
physical entity: unknown receptor-sAPPA
stoichiometric coefficient: 1.0

GNAQ
type: Protein
feature: GNAQ GNAQ s44 sa69 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re915 1516
type: Stoichiometry
physical entity: sAPPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re915 1517
type: Stoichiometry
physical entity: Unknown receptor
stoichiometric coefficient: 1.0

Modulation of gene expression
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB1_40-RIGHT__AmyloidB_aggregation-_re1351
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: AmyloidB aggregation s3929 sa2848
controller: AmyloidB1-40

p3
type: Protein
cellular location: default

insulin s1138 sa2285 STOICHIOMETRY ID
type: Stoichiometry
physical entity: insulin
stoichiometric coefficient: 1.0

testosterone
type: SmallMolecule
cellular location: default

ATG3
type: Protein
cellular location: neuron c1

PSEN
type: Protein
feature: PSEN PSEN s2480 sa1942 rs1
cellular location: endoplasmic reticulum ER c5

N1
type: Protein
cellular location: default

STOICHIOMETRY ID s3323 csa219
type: Stoichiometry
physical entity: RAC1-GGPP
stoichiometric coefficient: 1.0

MIF
type: Protein
feature: MIF MIF s3469 sa2451 Active
cellular location: neuron c1

TRANSPORT_LEFT__ALB-RIGHT__ALB-_re371
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re371 615
participant stoichiometry: PARTICIPANT STOICHIOMETRY re371 614
conversion direction: LEFT_TO_RIGHT
left: ALB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ALB
xref: TRANSPORT

H2O s709 sa296 STOICHIOMETRY ID
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Cytokine upregulation
type: Pathway

TREM2 s3760 sa2670 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TREM2
stoichiometric coefficient: 1.0

LRP8
type: Protein
feature: LRP8 LRP8 s2109 sa1624 Active

KNOWN_TRANSITION_OMITTED_LEFT__acetyl_CoA-RIGHT__TCA_cycle-_re210
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: TCA cycle
controller: acetyl-CoA

NR1 NR2BR s3854 sa2773 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NR1 NR2BR s3854 sa2773
stoichiometric coefficient: 1.0

NOTCH s952 sa666 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOTCH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re301 463
type: Stoichiometry
physical entity: NOTCH Delta s3371 csa91
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re301 462
type: Stoichiometry
physical entity: Delta
stoichiometric coefficient: 1.0

Senile plaque
type: Pathway

ARL4C
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re21 33
type: Stoichiometry
physical entity: APP-APBB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 32
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RAS-RIGHT__RAS-_re495
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re495 821
participant stoichiometry: PARTICIPANT STOICHIOMETRY re495 820
conversion direction: LEFT_TO_RIGHT
left: RAS
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: RAS
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re21 31
type: Stoichiometry
physical entity: APBB1
stoichiometric coefficient: 1.0

PPARG ligand
type: Protein
cellular location: microglia c4

PGE2
type: SmallMolecule
cellular location: neuron c1

LDLR
type: Protein
cellular location: sinusoid c28

mutant APP
type: Protein
cellular location: default

NALP
type: Protein

glutamate s3921 sa2838 STOICHIOMETRY ID
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__L_Cystine-RIGHT__L_Cys-_re456
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re456 752
participant stoichiometry: PARTICIPANT STOICHIOMETRY re456 753
conversion direction: LEFT_TO_RIGHT
left: L-Cystine
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: L-Cys
xref: STATE TRANSITION

APP
type: Protein
cellular location: endoplasmic reticulum ER c5

PSENEN s2941 sa2311 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSENEN
stoichiometric coefficient: 2.0

inflammation
type: Pathway

UNKNOWN_INHIBITION_LEFT__PPARG_-RIGHT__BACE1_-_re1353
type: Control
interaction type: CELLDESIGNER INTERACTION VOCABULARY=UNKNOWN INHIBITION
xref: UNKNOWN INHIBITION
xref: INHIBITION
controlled: neurite outgrouth
name: INHIBITION_LEFT__TLR8-RIGHT__neurite_outgrouth-_re1352
controller: TLR8

STATE_TRANSITION_LEFT__sphingomyelin-RIGHT__sphingomyelin-_re1128
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1128 1770
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1128 1769
conversion direction: LEFT_TO_RIGHT
left: sphingomyelin
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sphingomyelin
xref: STATE TRANSITION

MT-ND
type: Protein
feature: MT ND MT ND s186 sa281 Active
cellular location: inner membrane c8

unknown NT s1539 sa1185 STOICHIOMETRY ID
type: Stoichiometry
physical entity: unknown NT
stoichiometric coefficient: 1.0

homo-Cys
type: SmallMolecule
cellular location: neuron c1

ST8SIA1 s2076 sa1594 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ST8SIA1
stoichiometric coefficient: 1.0

ATP
type: Protein
feature: ATP ATP s193 sa300 Active
cellular location: inner membrane c8

FTI s2403 sa2284 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FTI
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__LIN7-RIGHT__protein_trafficking-_re985
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: protein trafficking
controller: LIN7

PARTICIPANT STOICHIOMETRY re252 363
type: Stoichiometry
physical entity: gro-LEF1-HDAC-TCF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re252 365
type: Stoichiometry
physical entity: gro s1753 sa1291
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re252 364
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re252 367
type: Stoichiometry
physical entity: HDAC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re252 366
type: Stoichiometry
physical entity: TCF LEF1 CTNNB1 s3300 csa62
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3183 csa104
type: Stoichiometry
physical entity: GABA-GABR
stoichiometric coefficient: 1.0

PGK s3488 sa250 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PGK s3488 sa250
stoichiometric coefficient: 1.0

pyruvate
type: SmallMolecule
cellular location: neuron c1

GSK3B s1431 sa1093 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 3.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_RAGE-RIGHT__RAGE_AmyloidB-_re1282
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1282 2023
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1282 2024
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1282 2022
conversion direction: LEFT_TO_RIGHT
left: RAGE
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: RAGE AmyloidB s3804 csa310
spontaneous: true
xref: HETERODIMER ASSOCIATION

MT-ND
type: Protein
cellular location: inner membrane c8

cGMP
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1235 1947
type: Stoichiometry
physical entity: NALP3 s3721 sa2631
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1235 1948
type: Stoichiometry
physical entity: NALP3 s3721 sa2630
stoichiometric coefficient: 1.0

LRP1
type: Protein
cellular location: sinusoid c28

ADDLs s1920 sa1442 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADDLs s1920 sa1442
stoichiometric coefficient: 1.0

MAPK signaling pathway
type: Pathway

APP s3655 sa2570 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 2.0

NO
type: SmallMolecule

CEX1
type: RnaRegion
cellular location: neuron c1

CASP2 s1761 sa1302 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP2 s1761 sa1302
stoichiometric coefficient: 1.0

Insulin-NMDAR
type: Complex
component: insulin s3887 sa2807
component: NMDAR s3894 sa2812
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re301 461
type: Stoichiometry
physical entity: NOTCH ectodomain
stoichiometric coefficient: 1.0

EIF2A
type: Protein
cellular location: neuron c1

H2O2 s1924 sa1447 STOICHIOMETRY ID
type: Stoichiometry
physical entity: H2O2 s1924 sa1447
stoichiometric coefficient: 2.0

ALB
type: Protein
cellular location: CSF c16

NFKB
type: Protein
feature: NFKB NFKB s3632 sa2626 Active
cellular location: microglia c4

HSD17B10
type: Protein

CASK s2747 sa2212 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASK
stoichiometric coefficient: 1.0

RAS
type: Protein
feature: RAS RAS s1418 sa1078 Active
cellular location: neuron c1

MAPT
type: Protein
feature: MAPT MAPT s146 sa86 rs1
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1246 1980
type: Stoichiometry
physical entity: TLRs-PAMPs
stoichiometric coefficient: 1.0

NICD
type: Protein
cellular location: nucleus c3

S100/calgranulin
type: Protein

LRP1 s3604 sa2507 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP1 s3604 sa2507
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__FOXO-RIGHT__TIMP1-_re281
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re281 432
participant stoichiometry: PARTICIPANT STOICHIOMETRY re281 431
conversion direction: LEFT_TO_RIGHT
left: FOXO
interaction type: UNKNOWN_TRANSITION
right: TIMP1
xref: UNKNOWN TRANSITION

PARTICIPANT STOICHIOMETRY re1246 1978
type: Stoichiometry
physical entity: TLRs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1246 1979
type: Stoichiometry
physical entity: PAMPs
stoichiometric coefficient: 1.0

PP1
type: Protein
feature: PP1 PP1 s3846 sa2756 Active
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__proinflammation-RIGHT__MAPK_signaling_pathway-_re1262
type: Interaction
participant: proinflammation
participant: MAPK signaling pathway
xref: KNOWN TRANSITION OMITTED

APOE-SDC2-Lipoprotein remnant
type: Complex
component: Lipoprotein remnant
component: SDC2
component: APOE s470 sa315
cellular location: sinusoid c28

Kv3.4
type: Protein
feature: Kv3.4 Kv3.4 s3785 sa2694 Active
cellular location: neuron c1

H2O
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re372 618
type: Stoichiometry
physical entity: TTR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__EGF_EGFR-_re491
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re491 814
conversion direction: LEFT_TO_RIGHT
left: EGF-EGFR
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__apoptosis-RIGHT__Cell_Death-_re57
type: Interaction
participant: apoptosis s63 sa102
participant: Cell Death s119 sa77
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re749 1205
type: Stoichiometry
physical entity: ATG13
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re749 1204
type: Stoichiometry
physical entity: ATG13
stoichiometric coefficient: 1.0

PSEN s178 sa110 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSEN
stoichiometric coefficient: 1.0

TNFA
type: DnaRegion
cellular location: astrocyte c2

PARTICIPANT STOICHIOMETRY re372 619
type: Stoichiometry
physical entity: TTR
stoichiometric coefficient: 1.0

ACO1 s1478 sa1132 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACO1 s1478 sa1132
stoichiometric coefficient: 2.0

Neuronal injury
type: Pathway

LPL s80 sa375 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LPL
stoichiometric coefficient: 4.0

STATE_TRANSITION_LEFT__FNTA-RIGHT__FNTA-_re863
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re863 1410
participant stoichiometry: PARTICIPANT STOICHIOMETRY re863 1409
conversion direction: LEFT_TO_RIGHT
left: FNTA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FNTA
xref: STATE TRANSITION

GGPP s1102 sa806 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GGPP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAPK11-RIGHT__MAPK11-_re603
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re603 1022
participant stoichiometry: PARTICIPANT STOICHIOMETRY re603 1023
conversion direction: LEFT_TO_RIGHT
left: MAPK11 s1799 sa1335
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPK11 s1797 sa1333
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__Phagocytosis-_re432
type: Interaction
participant: Microglia Activation
participant: Phagocytosis
xref: KNOWN TRANSITION OMITTED

STXBP1 s2746 sa2210 STOICHIOMETRY ID
type: Stoichiometry
physical entity: STXBP1
stoichiometric coefficient: 1.0

AmyloidB production increase
type: Pathway

AMPAR s3850 sa2769 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AMPAR
stoichiometric coefficient: 1.0

cGMP s1181 sa872 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

MMP
type: RnaRegion
cellular location: neuron c1

C1Q-AmyloidB1-42-C3B
type: Complex
component: AmyloidB1 42 s1284 sa947
component: C3B
component: C1Q
cellular location: default

PP1
type: Protein
cellular location: neuron c1

differentiation
type: Pathway

re747 s3460 sa2056 1195
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__MTOR-RIGHT__MTOR-_re747
control type: INHIBITION
controller: FKBP8

PARTICIPANT STOICHIOMETRY re725 1174
type: Stoichiometry
physical entity: LRP8
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__TNF-_re1115
type: Interaction
participant: Microglia Activation
participant: TNF s2777 sa2240
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re648 1079
type: Stoichiometry
physical entity: APC-GSK3B-AXIN-CTNNB1
stoichiometric coefficient: 1.0

NCOA-RXR-RARA-ATRA
type: Complex
component: ATRA s732 sa418
component: RARA s1693 sa412
component: NCOA s728 sa417
component: RXR s716 sa411
cellular location: nucleus c3

STOICHIOMETRY ID s3274 csa189
type: Stoichiometry
physical entity: VLDLR-RELN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1238 1955
type: Stoichiometry
physical entity: ASC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1238 1956
type: Stoichiometry
physical entity: inflammasome
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1238 1953
type: Stoichiometry
physical entity: NALP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1238 1954
type: Stoichiometry
physical entity: IPAF
stoichiometric coefficient: 1.0

NOS s157 sa95 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re725 1176
type: Stoichiometry
physical entity: LRP8-APOE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1238 1952
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re725 1175
type: Stoichiometry
physical entity: APOE s607 sa177
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 5
type: Stoichiometry
physical entity: NAC
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PI_4,5_P2-RIGHT__DAG_IP3-_re590
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re590 980
participant stoichiometry: PARTICIPANT STOICHIOMETRY re590 979
conversion direction: LEFT_TO_RIGHT
left: PI(4,5)P2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: DAG-IP3
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__EIF2A-RIGHT__selective_chaperone_translation-_re853
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: selective chaperone translation
controller: EIF2A

PARTICIPANT STOICHIOMETRY re322 496
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 4
type: Stoichiometry
physical entity: SNCA s50 sa51
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re322 497
type: Stoichiometry
physical entity: ACh-CHRM
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re322 495
type: Stoichiometry
physical entity: CHRM
stoichiometric coefficient: 1.0

CD3D
type: Protein
feature: CD3D CD3D s2463 sa2370 rs1

PARTICIPANT STOICHIOMETRY re827 1331
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re827 1330
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

re867 s2487 sa1955 1414
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__GDI-RIGHT__GDI-_re867
control type: INHIBITION
controller: GDF s2487 sa1955

NGF
type: Protein
cellular location: default

G1
type: Pathway

MAPK12
type: Protein
feature: MAPK12 MAPK12 s1800 sa1337 Active
feature: MAPK12 MAPK12 s1800 sa1337 rs1
cellular location: MAPK cascade c6

BID
type: Protein
feature: BID BID s43 sa27 Active
cellular location: neuron c1

O2 s1320 sa983 STOICHIOMETRY ID
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 2.0

NTRK2 s2595 sa1803 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTRK2
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__Met-RIGHT__Met_sulfide_radical_cation-_re363
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re363 591
participant stoichiometry: PARTICIPANT STOICHIOMETRY re363 590
conversion direction: LEFT_TO_RIGHT
left: Met
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Met sulfide radical cation
xref: STATE TRANSITION

SRA1
type: Protein
cellular location: microglia c4

re420 s1274 sa937 700
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__BACE1-RIGHT__BACE1-_re420
control type: INHIBITION
controller: PPARG

PARTICIPANT STOICHIOMETRY re1171 1835
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1171 1836
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAC:_membrane_attack_complex-RIGHT__activate_microglia_inflammatory_processes-_re996
type: Control
xref: STATE TRANSITION
controlled: activate microglia inflammatory processes
controller: MAC: membrane attack complex

estrogen
type: SmallMolecule
cellular location: inner membrane c8

HRK
type: Protein
cellular location: MAPK cascade c6

unknown protein s3762 sa2672 STOICHIOMETRY ID
type: Stoichiometry
physical entity: unknown protein
stoichiometric coefficient: 1.0

BID
type: Protein
cellular location: neuron c1

STOICHIOMETRY ID s3220 csa123
type: Stoichiometry
physical entity: C3A-AmyloidB1-42
stoichiometric coefficient: 1.0

PLG
type: Protein
cellular location: default

TXN
type: Protein
cellular location: neuron c1

Na+
type: SmallMolecule
cellular location: default

STATE_TRANSITION_LEFT__TNFA-RIGHT__TNFA-_re1203
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1203 1892
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1203 1891
conversion direction: LEFT_TO_RIGHT
left: TNFA s3648 sa2558
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNFA
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__TNF-RIGHT__TNF-_re778
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re778 1250
participant stoichiometry: PARTICIPANT STOICHIOMETRY re778 1249
conversion direction: LEFT_TO_RIGHT
left: TNF s2777 sa2240
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNF s2777 sa2241
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__TNFA-RIGHT__TNFA-_re1202
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1202 1889
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1202 1890
conversion direction: LEFT_TO_RIGHT
left: TNFA s3630 sa2534
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNFA
xref: STATE TRANSITION

STOICHIOMETRY ID s3711 csa300
type: Stoichiometry
physical entity: TLR4-DAMPs
stoichiometric coefficient: 1.0

estrogen s904 sa621 STOICHIOMETRY ID
type: Stoichiometry
physical entity: estrogen
stoichiometric coefficient: 2.0

FADD
type: Protein

LRP8 s2109 sa1624 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP8
stoichiometric coefficient: 2.0

STOICHIOMETRY ID s3275 csa13
type: Stoichiometry
physical entity: APP SORL1 s3275 csa13
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__G_Secretase-RIGHT__Microglia_Activation-_re625
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Microglia Activation
controller: G-Secretase

C3A
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re495 821
type: Stoichiometry
physical entity: RAS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re698 1127
type: Stoichiometry
physical entity: WIF1 s2028 sa1548
stoichiometric coefficient: 1.0

ACh
type: SmallMolecule
cellular location: default

PARTICIPANT STOICHIOMETRY re495 820
type: Stoichiometry
physical entity: RAS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re698 1128
type: Stoichiometry
physical entity: WNT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re698 1129
type: Stoichiometry
physical entity: WIF-WNT
stoichiometric coefficient: 1.0

s78
type: Complex
component: LPL
component: APOE s470 sa315

SDC2 s2863 sa2268 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SDC2
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__neuronal_stem_cell-RIGHT__differentiation-_re790
type: Interaction
participant: differentiation
participant: neuronal stem cell s2276 sa1770
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re723 1170
type: Stoichiometry
physical entity: VLDLR-APOE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1187 1873
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1187 1874
type: Stoichiometry
physical entity: NO s159 sa97
stoichiometric coefficient: 1.0

3 mercaptopyruvate s1349 sa1013 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 3-mercaptopyruvate
stoichiometric coefficient: 1.0

STX s2748 sa2214 STOICHIOMETRY ID
type: Stoichiometry
physical entity: STX
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GTP-_GTPase-RIGHT__GDP-_GTPase-_re869
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re869 1421
participant stoichiometry: PARTICIPANT STOICHIOMETRY re869 1423
participant stoichiometry: PARTICIPANT STOICHIOMETRY re869 1422
participant stoichiometry: PARTICIPANT STOICHIOMETRY re869 1424
conversion direction: LEFT_TO_RIGHT
left: GTP
left: GTPase s2864 sa2269
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GTPase
right: GDP
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re723 1169
type: Stoichiometry
physical entity: APOE s607 sa177
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3375 csa255
type: Stoichiometry
physical entity: APBB1 AICD LBP 1 TFCP2 PCBP2 s3375 csa255
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re723 1168
type: Stoichiometry
physical entity: VLDLR s2093 sa1615
stoichiometric coefficient: 1.0

increase NFKBIA NFKBIB
type: Pathway

C7
type: Protein

VLDLR s2093 sa1615 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VLDLR s2093 sa1615
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re743 1183
type: Stoichiometry
physical entity: ADRBK1
stoichiometric coefficient: 1.0

Oligomeric AmyloidB
type: Protein
cellular location: neuron c1

C5B s363 sa7 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C5B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re743 1185
type: Stoichiometry
physical entity: ADRBK1-PEBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re743 1184
type: Stoichiometry
physical entity: PEBP1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__ATG16-_ATG12_ATG6-RIGHT__ATG12_ATG5_ATG16-_re759
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re759 1228
participant stoichiometry: PARTICIPANT STOICHIOMETRY re759 1227
participant stoichiometry: PARTICIPANT STOICHIOMETRY re759 1226
conversion direction: LEFT_TO_RIGHT
left: ATG12-ATG6
left: ATG16
interaction type: HETERODIMER_ASSOCIATION
right: ATG12-ATG5-ATG16
spontaneous: true
xref: HETERODIMER ASSOCIATION

steroid hormones s1109 sa813 STOICHIOMETRY ID
type: Stoichiometry
physical entity: steroid hormones s1109 sa813
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__IKBK-RIGHT__IKBK-_re651
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re651 1088
participant stoichiometry: PARTICIPANT STOICHIOMETRY re651 1089
conversion direction: LEFT_TO_RIGHT
left: IKBK
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IKBK
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__LDLR-_APOE_Lipoprotein_remnant-RIGHT__LDLR_APOE_Lipoprotein_remnant-_re617
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re617 1037
participant stoichiometry: PARTICIPANT STOICHIOMETRY re617 1038
participant stoichiometry: PARTICIPANT STOICHIOMETRY re617 1039
conversion direction: LEFT_TO_RIGHT
left: APOE Lipoprotein remnant s3361 csa166
left: LDLR
interaction type: HETERODIMER_ASSOCIATION
right: LDLR-APOE-Lipoprotein remnant
spontaneous: true
xref: HETERODIMER ASSOCIATION

CIB1 s2427 sa1901 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CIB1
stoichiometric coefficient: 1.0

DVL s2834 sa463 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DVL s2834 sa463
stoichiometric coefficient: 1.0

GABARAPL2 s2225 sa1709 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GABARAPL2
stoichiometric coefficient: 2.0

N APP s3656 sa2571 STOICHIOMETRY ID
type: Stoichiometry
physical entity: N APP s3656 sa2571
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re428 714
type: Stoichiometry
physical entity: C3A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re428 715
type: Stoichiometry
physical entity: C1Q-AmyloidB1-42-C3B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re428 716
type: Stoichiometry
physical entity: C1Q
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re428 717
type: Stoichiometry
physical entity: C3A-AmyloidB1-42
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re428 718
type: Stoichiometry
physical entity: C3B s3489 sa946
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re340 537
type: Stoichiometry
physical entity: AcetoacetylCoA s1084 sa788
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re340 538
type: Stoichiometry
physical entity: HMG CoA
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__cholesterol-RIGHT__steroid_hormones-_re356
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re356 577
participant stoichiometry: PARTICIPANT STOICHIOMETRY re356 576
conversion direction: LEFT_TO_RIGHT
left: cholesterol s87 sa190
interaction type: KNOWN_TRANSITION_OMITTED
right: steroid hormones s1109 sa813
xref: KNOWN TRANSITION OMITTED

unknown
type: PhysicalEntity
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re340 536
type: Stoichiometry
physical entity: acetylcholine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAPK1_3-RIGHT__MAPK1_3-_re72
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re72 135
participant stoichiometry: PARTICIPANT STOICHIOMETRY re72 136
conversion direction: LEFT_TO_RIGHT
left: MAPK1/3
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPK1/3
xref: STATE TRANSITION

ADCY10
type: Protein
feature: ADCY10 ADCY10 s1999 sa908 Active

HETERODIMER_ASSOCIATION_LEFT__PPARG_RXR_unkown_repressor-_unknown_PPARG_ligand-RIGHT__unknown_repressor-_PPARG_RXR_unkown_PPARG_ligand-_re785
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re785 1261
participant stoichiometry: PARTICIPANT STOICHIOMETRY re785 1262
participant stoichiometry: PARTICIPANT STOICHIOMETRY re785 1263
participant stoichiometry: PARTICIPANT STOICHIOMETRY re785 1264
conversion direction: LEFT_TO_RIGHT
left: unknown PPARG ligand
left: PPARG RXR unkown repressor s3296 csa210
interaction type: HETERODIMER_ASSOCIATION
right: unknown repressor s2258 sa1756
right: PPARG-RXR-unkown PPARG ligand
spontaneous: true
xref: HETERODIMER ASSOCIATION

APBB1
type: Protein

PARTICIPANT STOICHIOMETRY re785 1261
type: Stoichiometry
physical entity: PPARG RXR unkown repressor s3296 csa210
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re785 1262
type: Stoichiometry
physical entity: unknown PPARG ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re785 1263
type: Stoichiometry
physical entity: unknown repressor s2258 sa1756
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re785 1264
type: Stoichiometry
physical entity: PPARG-RXR-unkown PPARG ligand
stoichiometric coefficient: 1.0

TNF s3796 sa2708 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNF s3796 sa2708
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__NAC-RIGHT__Senile_plaque-_re8
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Senile plaque
controller: NAC

KNOWN_TRANSITION_OMITTED_LEFT__Generation_of_reactive_oxygen_species-RIGHT__Lipid_peroxidation-_re121
type: Interaction
participant: Generation of reactive oxygen species
participant: Lipid peroxidation
xref: KNOWN TRANSITION OMITTED

ATG13
type: Protein
feature: ATG13 ATG13 s2150 sa1661 rs1
feature: ATG13 ATG13 s2150 sa1661 rs3
feature: ATG13 ATG13 s2150 sa1661 rs2
cellular location: neuron c1

IREB2 s1473 sa1134 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IREB2
stoichiometric coefficient: 1.0

HMG CoA s1085 sa789 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HMG CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1130 1773
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

ATG13
type: Protein
feature: ATG13 ATG13 s2157 sa1668 rs2
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re760 1229
type: Stoichiometry
physical entity: ATG12-ATG5-ATG16
stoichiometric coefficient: 1.0

NFKB responsive genes
type: DnaRegion
cellular location: nucleus c3

PRKG1-cGMP
type: Complex
component: PRKG1
component: cGMP s1272 sa936
cellular location: postsynaptic density c12

PLA2G1B
type: Protein
feature: PLA2G1B PLA2G1B s3465 sa2170 Active
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__Unknown_transportation-RIGHT__LRP1_AmyloidB-_re1020
type: Interaction
participant: Unknown transportation
participant: LRP1 AmyloidB s3387 csa262
xref: KNOWN TRANSITION OMITTED

VLDLR s2103 sa1620 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VLDLR
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re982 1620
type: Stoichiometry
physical entity: STX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re982 1621
type: Stoichiometry
physical entity: STX
stoichiometric coefficient: 1.0

IL1
type: RnaRegion
cellular location: nucleus c3

unknown
type: PhysicalEntity
cellular location: blood brain barrier BBB c22

PARTICIPANT STOICHIOMETRY re1091 1724
type: Stoichiometry
physical entity: GluR
stoichiometric coefficient: 1.0

LPL
type: Protein

PARTICIPANT STOICHIOMETRY re28 43
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re1091 1726
type: Stoichiometry
physical entity: GluR-glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 44
type: Stoichiometry
physical entity: TIMP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re156 245
type: Stoichiometry
physical entity: PRIM1-PCLB-APEX1-POLD1-replication origin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1091 1725
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 45
type: Stoichiometry
physical entity: H2O2
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__G_Secretase-RIGHT__Phagocytosis-_re638
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Phagocytosis
controller: G-Secretase

PARTICIPANT STOICHIOMETRY re156 246
type: Stoichiometry
physical entity: PRIM1-PCLB-APEX1-POLD1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1130 1774
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re293 456
type: Stoichiometry
physical entity: 26S Proteasome s3112 csa89
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re293 455
type: Stoichiometry
physical entity: ATP s890 sa613
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re293 457
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__Phagocytosis-RIGHT__IL1B-_re11
type: Interaction
participant: IL1B
participant: Phagocytosis
xref: UNKNOWN TRANSITION

Kv3.4 s3785 sa2694 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Kv3.4
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Oligomeric_AmyloidB-RIGHT__Senile_plaque-_re639
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Senile plaque
controller: Oligomeric AmyloidB

aldehydes
type: Pathway

PARTICIPANT STOICHIOMETRY re1058 1665
type: Stoichiometry
physical entity: C31
stoichiometric coefficient: 1.0

COX s2814 sa2255 STOICHIOMETRY ID
type: Stoichiometry
physical entity: COX
stoichiometric coefficient: 1.0

MAP2K3 s2819 sa1334 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP2K3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 39
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1058 1664
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

A2M
type: Protein
cellular location: Brain c26

ATG16 s2187 sa1705 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG16
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__HDAC-_NCOR2-_INPP5K-_NICD_LAG3_CSHL1-RIGHT__INPP5K_CSHL1_HDAC_NCOR2-_LAG3-_NICD-_re885
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re885 1450
participant stoichiometry: PARTICIPANT STOICHIOMETRY re885 1451
participant stoichiometry: PARTICIPANT STOICHIOMETRY re885 1452
participant stoichiometry: PARTICIPANT STOICHIOMETRY re885 1448
participant stoichiometry: PARTICIPANT STOICHIOMETRY re885 1449
participant stoichiometry: PARTICIPANT STOICHIOMETRY re885 1446
participant stoichiometry: PARTICIPANT STOICHIOMETRY re885 1447
conversion direction: LEFT_TO_RIGHT
left: NCOR2
left: NICD LAG3 CSHL1 s3184 csa241
left: HDAC
left: INPP5K
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NICD
right: LAG3
right: INPP5K-CSHL1-HDAC-NCOR2
xref: STATE TRANSITION

TRANSPORT_LEFT__PSEN-RIGHT__G_Secretase-_re1121
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1121 1761
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1121 1762
conversion direction: LEFT_TO_RIGHT
left: PSEN
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: G-Secretase
xref: TRANSPORT

RPS6KB s2613 sa2082 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RPS6KB
stoichiometric coefficient: 1.0

APP
type: Protein
cellular location: blood brain barrier BBB c22

TRANSLATION_LEFT__FPRL1-RIGHT__FPRL1-_re1217
type: TemplateReaction
participant: FPRL1
product: FPRL1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

TRANSLATION_LEFT__FPRL1-RIGHT__FPRL1-_re1218
type: TemplateReaction
participant: FPRL1
product: FPRL1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

RAF1-PEBP1
type: Complex
component: RAF1
component: PEBP1
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re24 40
type: Stoichiometry
physical entity: TNFRSF1A s2237 sa63
stoichiometric coefficient: 1.0

csa30 degraded s498 sa180 STOICHIOMETRY ID
type: Stoichiometry
physical entity: csa30_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re379 634
type: Stoichiometry
physical entity: NGFR-NGF
stoichiometric coefficient: 1.0

MAPK1 3 s194 sa125 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 1.0

PLA2G1B
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re379 633
type: Stoichiometry
physical entity: NGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re379 632
type: Stoichiometry
physical entity: NGF
stoichiometric coefficient: 2.0

NFKB1
type: Protein

TRANSCRIPTION_LEFT__PTGS2-RIGHT__PTGS2-_re108
type: TemplateReaction
participant: PTGS2
participant: PTGS2 s395 sa155
product: PTGS2 s395 sa155
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

activate astrocyte
type: Pathway

MY s2045 sa1560 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MY
stoichiometric coefficient: 1.0

IL6-IL6R
type: Complex
component: IL6
component: IL6R
cellular location: neuron c1

IL1B
type: Protein
cellular location: astrocyte c2

HETERODIMER_ASSOCIATION_LEFT__cholesterol-_NPC-RIGHT__NPC_cholesterol-_re1137
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1137 1785
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1137 1784
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1137 1786
conversion direction: LEFT_TO_RIGHT
left: NPC s513 sa187
left: cholesterol s3164 sa188
interaction type: HETERODIMER_ASSOCIATION
right: NPC cholesterol s3382 csa282
spontaneous: true
xref: HETERODIMER ASSOCIATION

ATP s193 sa300 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PSEN1
type: Protein

APP
type: DnaRegion
cellular location: neuron c1

MMP9
type: Protein
feature: MMP9 MMP9 s1013 sa723 Active
cellular location: default

AGER-AmyloidB fibril
type: Complex
component: AmyloidB fibril
component: AGER
cellular location: microglia c4

WNT s2065 sa1583 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT s2065 sa1583
stoichiometric coefficient: 1.0

20S s3113 sa586 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 20S
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__GluR-_glutamate-RIGHT__GluR_glutamate-_re1091
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1091 1724
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1091 1726
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1091 1725
conversion direction: LEFT_TO_RIGHT
left: glutamate
left: GluR
interaction type: HETERODIMER_ASSOCIATION
right: GluR-glutamate
spontaneous: true
xref: HETERODIMER ASSOCIATION

UNKNOWN_TRANSITION_LEFT__TNFRSF1A-RIGHT__TNFRSF1A-_re16
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 15
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 16
conversion direction: LEFT_TO_RIGHT
left: TNFRSF1A s2237 sa67
interaction type: UNKNOWN_TRANSITION
right: TNFRSF1A s2237 sa63
xref: UNKNOWN TRANSITION

TRANSPORT_LEFT__H_PLUS_-RIGHT__H_PLUS_-_re220
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re220 314
participant stoichiometry: PARTICIPANT STOICHIOMETRY re220 315
conversion direction: LEFT_TO_RIGHT
left: H+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: H+
xref: TRANSPORT

APP-ACO1-Fe
type: Complex
component: ACO1 s1478 sa1132
component: Fe s1455 sa1110
component: APP s1736 sa1116
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__CASP8-RIGHT__TNFRSF1A_FADD_CASP8-_re23
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 38
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 37
conversion direction: LEFT_TO_RIGHT
left: CASP8
interaction type: HETERODIMER_ASSOCIATION
right: TNFRSF1A-FADD-CASP8
spontaneous: true
xref: HETERODIMER ASSOCIATION

NTRK2-NTF4
type: Complex
component: NTRK2
component: NTF4 s2304 sa1800
cellular location: neuron c1

STOICHIOMETRY ID s3293 csa259
type: Stoichiometry
physical entity: APP-SHC1
stoichiometric coefficient: 1.0

Uridine di phospho N acetylglucosamine pyrophosphorylase s3923 sa2840 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Uridine di-phospho-N-acetylglucosamine pyrophosphorylase
stoichiometric coefficient: 1.0

TLR4
type: Protein
cellular location: microglia c4

HETERODIMER_ASSOCIATION_LEFT__TLR_AmyloidB-_AmyloidB-RIGHT__TLR-_re1160
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1160 1808
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1160 1809
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1160 1810
conversion direction: LEFT_TO_RIGHT
left: TLR-AmyloidB
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: TLR
xref: HETERODIMER ASSOCIATION

re371 s48 sa844 612
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__ALB-RIGHT__ALB-_re371
control type: INHIBITION
controller: TNF

CD3G
type: Protein

GluR s3050 sa2396 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GluR
stoichiometric coefficient: 1.0

replication origin
type: DnaRegion

HETERODIMER_ASSOCIATION_LEFT__NTF4-_NGFR-RIGHT__NGFR_NTF4-_re799
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re799 1287
participant stoichiometry: PARTICIPANT STOICHIOMETRY re799 1289
participant stoichiometry: PARTICIPANT STOICHIOMETRY re799 1288
conversion direction: LEFT_TO_RIGHT
left: NGFR
left: NTF4
interaction type: HETERODIMER_ASSOCIATION
right: NGFR NTF4 s3278 csa215
spontaneous: true
xref: HETERODIMER ASSOCIATION

PP1 s3846 sa2758 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PP1
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3590 csa284
type: Stoichiometry
physical entity: TLR4 AmyloidB s3590 csa284
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__Mevalonate_PP-RIGHT__IPP-_re344
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re344 550
participant stoichiometry: PARTICIPANT STOICHIOMETRY re344 549
conversion direction: LEFT_TO_RIGHT
left: Mevalonate PP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IPP
xref: STATE TRANSITION

AXIN
type: Protein

ATG7 s2202 sa1698 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG7
stoichiometric coefficient: 1.0

EDN1 s1642 sa1256 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EDN1 s1642 sa1256
stoichiometric coefficient: 1.0

CTNNB1
type: Protein
cellular location: nucleus c3

APOE
type: Protein
cellular location: Brain c26

STOICHIOMETRY ID s3243 csa148
type: Stoichiometry
physical entity: AmyloidB CLU s3243 csa148
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re100 169
type: Stoichiometry
physical entity: C6 s360 sa8
stoichiometric coefficient: 1.0

TR-LCK-CD4
type: Complex
component: LCK s2442 sa1917
component: TR
component: CD4
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re100 168
type: Stoichiometry
physical entity: C7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re100 170
type: Stoichiometry
physical entity: C5B
stoichiometric coefficient: 1.0

G-Secretase
type: Complex
component: NCSTN
component: PSEN1
component: APH1
component: PSENEN
cellular location: neuron c1

STATE_TRANSITION_RIGHT__APC_GSK3B_AXIN_CTNNB1-_re648
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re648 1079
conversion direction: LEFT_TO_RIGHT
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APC-GSK3B-AXIN-CTNNB1
xref: STATE TRANSITION

STATE_TRANSITION_RIGHT__APC_GSK3B_AXIN_CTNNB1-_re649
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re649 1080
conversion direction: LEFT_TO_RIGHT
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APC-GSK3B-AXIN-CTNNB1
xref: STATE TRANSITION

ESR1
type: Protein
feature: ESR1 ESR1 s2072 sa1590 Active
cellular location: nucleus c3

TNF
type: Protein

KNOWN_TRANSITION_OMITTED_LEFT__NO-RIGHT__neurotoxin-_re1105
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: neurotoxin s3062 sa2418
controller: NO

PARTICIPANT STOICHIOMETRY re218 306
type: Stoichiometry
physical entity: Ubiquinol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re100 171
type: Stoichiometry
physical entity: MAC: membrane attack complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re218 305
type: Stoichiometry
physical entity: MT-ND
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re218 304
type: Stoichiometry
physical entity: MT-ND
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__RAGE-_AGE-RIGHT__AGE_RAGE-_re1322
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1322 2112
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1322 2113
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1322 2111
conversion direction: LEFT_TO_RIGHT
left: AGE s3873 sa2790
left: RAGE s3872 sa2789
interaction type: HETERODIMER_ASSOCIATION
right: AGE-RAGE
spontaneous: true
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__ceramide-RIGHT__DAG-_re832
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re832 1341
participant stoichiometry: PARTICIPANT STOICHIOMETRY re832 1342
conversion direction: LEFT_TO_RIGHT
left: ceramide
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: DAG
xref: STATE TRANSITION

autophagosome formation
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__Oligomeric_AmyloidB-RIGHT__neuronal_cell_death-_re640
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: neuronal cell death s1916 sa1438
controller: Oligomeric AmyloidB

TREM1 s3691 sa2604 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TREM1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SLC8A-RIGHT__SLC8A-_re934
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re934 1556
participant stoichiometry: PARTICIPANT STOICHIOMETRY re934 1555
conversion direction: LEFT_TO_RIGHT
left: SLC8A
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: SLC8A
xref: STATE TRANSITION

cholesterol
type: SmallMolecule

TLR2-AmyloidB
type: Complex
component: TLR2
component: AmyloidB
cellular location: microglia c4

STOICHIOMETRY ID s3302 csa261
type: Stoichiometry
physical entity: NOTCH ectodomain-Delta
stoichiometric coefficient: 1.0

USP17L2
type: Protein
cellular location: neuron c1

FTH-ACO1-IREB2
type: Complex
component: FTH
component: IREB2 s1484 sa1138
component: ACO1 s1458 sa1114
cellular location: neuron c1

STATE_TRANSITION_LEFT__FYN-RIGHT__MAPK-_re1047
type: Control
xref: STATE TRANSITION
controlled: MAPK
controller: FYN s3455 sa1524

KCN s2646 sa2105 STOICHIOMETRY ID
type: Stoichiometry
physical entity: KCN
stoichiometric coefficient: 1.0

PMVK s1091 sa795 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PMVK s1091 sa795
stoichiometric coefficient: 1.0

NMDAR
type: Protein

DAB s1647 sa1261 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DAB
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3235 csa144
type: Stoichiometry
physical entity: FTH-PCBP2-40S-60S
stoichiometric coefficient: 1.0

C1Q s3485 sa24 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C1Q
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__ceramide-RIGHT__sphingosine-_re810
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re810 1304
participant stoichiometry: PARTICIPANT STOICHIOMETRY re810 1305
conversion direction: LEFT_TO_RIGHT
left: ceramide
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sphingosine
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__PDH-RIGHT__PDH-_re204
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re204 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY re204 294
conversion direction: LEFT_TO_RIGHT
left: PDH
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PDH
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__PDH-RIGHT__PDH-_re205
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re205 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY re205 297
conversion direction: LEFT_TO_RIGHT
left: PDH
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PDH
xref: STATE TRANSITION

PCBP1 s1493 sa1144 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PCBP1 s1493 sa1144
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__FOXO-RIGHT__FOXO-_re828
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re828 1334
participant stoichiometry: PARTICIPANT STOICHIOMETRY re828 1333
conversion direction: LEFT_TO_RIGHT
left: FOXO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FOXO
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__HMG_CoA-RIGHT__mevalonic_acid-_re341
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re341 540
participant stoichiometry: PARTICIPANT STOICHIOMETRY re341 541
conversion direction: LEFT_TO_RIGHT
left: HMG CoA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: mevalonic acid
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re799 1287
type: Stoichiometry
physical entity: NTF4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re592 985
type: Stoichiometry
physical entity: DAG-IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re799 1289
type: Stoichiometry
physical entity: NGFR NTF4 s3278 csa215
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re854 1396
type: Stoichiometry
physical entity: XBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re592 986
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re799 1288
type: Stoichiometry
physical entity: NGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re854 1397
type: Stoichiometry
physical entity: XBP1
stoichiometric coefficient: 1.0

PDH s655 sa253 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PDH
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

UNKNOWN_TRANSITION_LEFT__APBB1_AICD-RIGHT__APBB1_AICD-_re308
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re308 467
participant stoichiometry: PARTICIPANT STOICHIOMETRY re308 466
conversion direction: LEFT_TO_RIGHT
left: APBB1-AICD
interaction type: UNKNOWN_TRANSITION
right: APBB1-AICD
xref: UNKNOWN TRANSITION

TRANSPORT_LEFT__ACTA1-RIGHT__ACTA1-_re448
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re448 734
participant stoichiometry: PARTICIPANT STOICHIOMETRY re448 735
conversion direction: LEFT_TO_RIGHT
left: ACTA1 s1317 sa980
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ACTA1
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re852 1390
type: Stoichiometry
physical entity: EIF2A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re852 1391
type: Stoichiometry
physical entity: EIF2A
stoichiometric coefficient: 1.0

IREB2 s1492 sa1142 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IREB2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GSK3B-RIGHT__GSK3B-_re1120
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1120 1759
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1120 1760
conversion direction: LEFT_TO_RIGHT
left: GSK3B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GSK3B
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__3_mercaptopyruvate-_sulfite-RIGHT__thiosulfate-_pyruvate-_re480
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re480 785
participant stoichiometry: PARTICIPANT STOICHIOMETRY re480 786
participant stoichiometry: PARTICIPANT STOICHIOMETRY re480 787
participant stoichiometry: PARTICIPANT STOICHIOMETRY re480 784
conversion direction: LEFT_TO_RIGHT
left: sulfite s1346 sa1010
left: 3-mercaptopyruvate
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: pyruvate
right: thiosulfate
xref: STATE TRANSITION

LRP1
type: Protein
cellular location: blood brain barrier BBB c22

TUB
type: Protein
feature: TUB TUB s930 sa649 rs1
cellular location: neuron c1

GluR-glutamate
type: Complex
component: GluR
component: glutamate s1206 sa1497
cellular location: astrocyte c2

KNOWN_TRANSITION_OMITTED_LEFT__APOE_AmyloidB-RIGHT__Unknown_transportation-_re1029
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Unknown transportation
controller: APOE-AmyloidB

starvation condition
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__SMPD2-RIGHT__Abnormal_ceramide_accumulation-_re1015
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Abnormal ceramide accumulation s2959 sa2331
controller: SMPD2 s1515 sa1160

KNOWN_TRANSITION_OMITTED_LEFT__SMPD2-RIGHT__Abnormal_ceramide_accumulation-_re1016
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Abnormal ceramide accumulation s2959 sa2331
controller: SMPD2

VEGFA s2611 sa2078 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VEGFA
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__SMPD2-RIGHT__Abnormal_ceramide_accumulation-_re1012
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Abnormal ceramide accumulation s2959 sa2331
controller: SMPD2

GR
type: Protein
feature: GR GR s3537 sa892 Active

KNOWN_TRANSITION_OMITTED_LEFT__SMPD2-RIGHT__Abnormal_ceramide_accumulation-_re1013
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Abnormal ceramide accumulation s2959 sa2331
controller: SMPD2

KNOWN_TRANSITION_OMITTED_LEFT__SMPD2-RIGHT__Abnormal_ceramide_accumulation-_re1014
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Abnormal ceramide accumulation s2959 sa2331
controller: SMPD2 s1510 sa1154

VLDLR
type: Protein
feature: VLDLR VLDLR s2103 sa1620 Active

PARTICIPANT STOICHIOMETRY re396 654
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re396 656
type: Stoichiometry
physical entity: glutamate-GRIN-Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re396 655
type: Stoichiometry
physical entity: GRIN Mg2 PLUS s3211 csa114
stoichiometric coefficient: 1.0

APOE s3450 sa200 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 2.0

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB-RIGHT__AmyloidB-_re559
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re559 942
participant stoichiometry: PARTICIPANT STOICHIOMETRY re559 943
conversion direction: LEFT_TO_RIGHT
left: AmyloidB s1546 sa1194
interaction type: KNOWN_TRANSITION_OMITTED
right: AmyloidB
xref: KNOWN TRANSITION OMITTED

STOICHIOMETRY ID s3285 csa247
type: Stoichiometry
physical entity: TF-Fe
stoichiometric coefficient: 1.0

SORL1
type: Protein
cellular location: neuron c1

FPRL1 s3817 sa2725 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FPRL1
stoichiometric coefficient: 1.0

cholesterol s3164 sa188 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cholesterol s3164 sa188
stoichiometric coefficient: 1.0

proliferation
type: Pathway

STATE_TRANSITION_LEFT__IRS1-RIGHT__IRS1-_re1324
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1324 2118
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1324 2119
conversion direction: LEFT_TO_RIGHT
left: IRS1 s3881 sa2802
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IRS1
xref: STATE TRANSITION

BCL2L1
type: Protein
feature: BCL2L1 BCL2L1 s1171 sa864 Active
cellular location: inner membrane c8

HETERODIMER_ASSOCIATION_LEFT__Fe-_FTH-RIGHT__FTH_ACO1_IREB2_Fe-_re914
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re914 1514
participant stoichiometry: PARTICIPANT STOICHIOMETRY re914 1513
participant stoichiometry: PARTICIPANT STOICHIOMETRY re914 1515
conversion direction: LEFT_TO_RIGHT
left: FTH
left: Fe
interaction type: HETERODIMER_ASSOCIATION
right: FTH-ACO1-IREB2-Fe
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re491 814
type: Stoichiometry
physical entity: EGF-EGFR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAPK13-RIGHT__MAPK13-_re605
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re605 1031
participant stoichiometry: PARTICIPANT STOICHIOMETRY re605 1030
conversion direction: LEFT_TO_RIGHT
left: MAPK13
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPK13
xref: STATE TRANSITION

NAC s61 sa56 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NAC
stoichiometric coefficient: 1.0

PGK
type: Protein
cellular location: default

inflammation
type: Pathway

SHC1 s2737 sa2205 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SHC1 s2737 sa2205
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NFKBI_NFKB1_RELA-_re652
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re652 1091
conversion direction: LEFT_TO_RIGHT
left: NFKBI-NFKB1-RELA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__peroxynitrite__ONOO__-RIGHT__DNA_damage-_re53
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: DNA damage
controller: peroxynitrite (ONOO-)

nutrient rich condition
type: Pathway

Mevalonate PP s1090 sa794 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Mevalonate PP
stoichiometric coefficient: 1.0

thiocysteine s1328 sa992 STOICHIOMETRY ID
type: Stoichiometry
physical entity: thiocysteine
stoichiometric coefficient: 1.0

Lanosterol s1108 sa812 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Lanosterol
stoichiometric coefficient: 1.0

CDK1 s3451 sa344 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDK1
stoichiometric coefficient: 3.0

AKT1
type: Protein
feature: AKT1 AKT1 s2090 sa1608 Active
cellular location: neuron c1

p3 s2947 sa2324 STOICHIOMETRY ID
type: Stoichiometry
physical entity: p3
stoichiometric coefficient: 1.0

NADH s3014 sa2366 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NADH s3014 sa2366
stoichiometric coefficient: 1.0

neurite outgrouth
type: Pathway

MIF
type: Protein
cellular location: neuron c1

Unknown TF s3467 sa2312 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Unknown TF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re598 1006
type: Stoichiometry
physical entity: WISP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re598 1007
type: Stoichiometry
physical entity: WISP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1340 2165
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re966 1586
type: Stoichiometry
physical entity: superoxide anion
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re966 1585
type: Stoichiometry
physical entity: superoxide anion
stoichiometric coefficient: 1.0

oxidase
type: Protein
cellular location: astrocyte c2

PARTICIPANT STOICHIOMETRY re1340 2164
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

re890 s197 sa126 1461
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__TSC-RIGHT__TSC-_re890
control type: INHIBITION
controller: MAPK1/3

PG
type: SmallMolecule
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re557 938
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re557 939
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

APP
type: Protein
cellular location: Brain c26

5-HT
type: SmallMolecule
cellular location: neuron c1

LRP8-APOE
type: Complex
component: LRP8
component: APOE s470 sa315
cellular location: neuron c1

TRANSPORT_LEFT__AmyloidB_TTR-RIGHT__AmyloidB_TTR-_re378
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re378 631
participant stoichiometry: PARTICIPANT STOICHIOMETRY re378 630
conversion direction: LEFT_TO_RIGHT
left: AmyloidB-TTR
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: AmyloidB TTR s3196 csa108
xref: TRANSPORT

BACE s3162 sa1889 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BACE
stoichiometric coefficient: 1.0

UNKNOWN_CATALYSIS
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re763 1232
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re763 1233
type: Stoichiometry
physical entity: GABARAPL2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re527 878
type: Stoichiometry
physical entity: 5 MTHF s1518 sa1163
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re527 877
type: Stoichiometry
physical entity: folate
stoichiometric coefficient: 1.0

MPST
type: Protein
cellular location: neuron c1

NOD1 s3663 sa2580 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOD1
stoichiometric coefficient: 1.0

NPD1
type: SmallMolecule
cellular location: neuron c1

STATE_TRANSITION_LEFT__Microglia_Activation-RIGHT__MAC:_membrane_attack_complex-_re995
type: Interaction
participant: Microglia Activation
participant: MAC: membrane attack complex
xref: STATE TRANSITION

STOICHIOMETRY ID s3322 csa54
type: Stoichiometry
physical entity: FZD LRP5 6 CSNK1A1 s3322 csa54
stoichiometric coefficient: 1.0

PRKAA2
type: Protein
cellular location: neuron c1

C terminal of p35
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re763 1231
type: Stoichiometry
physical entity: GABARAPL2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re763 1230
type: Stoichiometry
physical entity: ATP s890 sa613
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3892 csa323
type: Stoichiometry
physical entity: Insulin-NMDAR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re781 1256
type: Stoichiometry
physical entity: TNFRSF1A s2237 sa67
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re781 1257
type: Stoichiometry
physical entity: TNFRSF1A-TNF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re781 1255
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

UBA3 s778 sa504 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UBA3
stoichiometric coefficient: 1.0

PTGS2
type: DnaRegion
cellular location: neuron c1

IL4R
type: Protein

UB s892 sa603 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UB s892 sa603
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CASP6-RIGHT__CASP6-_re165
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re165 255
participant stoichiometry: PARTICIPANT STOICHIOMETRY re165 256
conversion direction: LEFT_TO_RIGHT
left: CASP6
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CASP6
xref: STATE TRANSITION

PDH
type: Protein
feature: PDH PDH s657 sa254 rs1
cellular location: neuron c1

FADD
type: Protein
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__NFKB-RIGHT__cell_surviving_response-_re1229
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: cell surviving response
controller: NFKB

PARTICIPANT STOICHIOMETRY re199 276
type: Stoichiometry
physical entity: PFK s3487 sa244
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re199 277
type: Stoichiometry
physical entity: PFK
stoichiometric coefficient: 1.0

SolublePRNP
type: Protein
cellular location: neuron c1

UBE2 s894 sa618 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UBE2 s894 sa618
stoichiometric coefficient: 1.0

sulfinyl pyruvate
type: SmallMolecule
cellular location: mitochondria c7

THSD1 s1046 sa753 STOICHIOMETRY ID
type: Stoichiometry
physical entity: THSD1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__LOO-RIGHT__HNE-_re971
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re971 1593
participant stoichiometry: PARTICIPANT STOICHIOMETRY re971 1594
conversion direction: LEFT_TO_RIGHT
left: LOO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HNE
xref: STATE TRANSITION

mutant PSEN
type: Protein
cellular location: default

STATE_TRANSITION_LEFT__TNFA-RIGHT__TNFA-_re1181
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1181 1866
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1181 1865
conversion direction: LEFT_TO_RIGHT
left: TNFA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNFA s3648 sa2558
xref: STATE TRANSITION

re1299 s3827 sa2736 2056
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__s3840-RIGHT__CEX1-_re1299
control type: INHIBITION
controller: NPD1

NADH
type: SmallMolecule
cellular location: mitochondia c13

NE
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re356 577
type: Stoichiometry
physical entity: steroid hormones s1109 sa813
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__TNFA-RIGHT__TNFA-_re1169
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1169 1828
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1169 1829
conversion direction: LEFT_TO_RIGHT
left: TNFA s3629 sa2533
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNFA s3630 sa2534
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re356 576
type: Stoichiometry
physical entity: cholesterol s87 sa190
stoichiometric coefficient: 1.0

thiocysteine
type: SmallMolecule
cellular location: neuron c1

E3 ubiquitin-ligase
type: Complex
component: SKP1 s794 sa513
component: FBXO s798 sa514
component: CUL
component: ROC1

HETERODIMER_ASSOCIATION_LEFT__TLRs-_PAMPs-RIGHT__TLRs_PAMPs-_re1246
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1246 1980
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1246 1978
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1246 1979
conversion direction: LEFT_TO_RIGHT
left: PAMPs
left: TLRs
interaction type: HETERODIMER_ASSOCIATION
right: TLRs-PAMPs
spontaneous: true
xref: HETERODIMER ASSOCIATION

GGTI s2388 sa1944 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GGTI
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__IL1-RIGHT__IL1-_re439
type: TemplateReaction
participant: IL1
product: IL1
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

sphingomyelin
type: Protein
feature: sphingomyelin sphingomyelin s2350 sa2444 rs1
cellular location: neuron c1

STOICHIOMETRY ID s3198 csa109
type: Stoichiometry
physical entity: NGFR-NGF
stoichiometric coefficient: 1.0

NEDD8 s779 sa507 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NEDD8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1331 2132
type: Stoichiometry
physical entity: FOXO1 s3895 sa2813
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1331 2133
type: Stoichiometry
physical entity: FOXO1 s3895 sa2813
stoichiometric coefficient: 1.0

PRKAA2
type: Protein
feature: PRKAA2 PRKAA2 s3461 sa2064 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re100 167
type: Stoichiometry
physical entity: C8
stoichiometric coefficient: 1.0

GSH s2700 sa2177 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSH
stoichiometric coefficient: 1.0

mutant PSEN s3025 sa2376 STOICHIOMETRY ID
type: Stoichiometry
physical entity: mutant PSEN
stoichiometric coefficient: 1.0

TRNAU1
type: RnaRegion
cellular location: neuron c1

PTEN
type: Protein
feature: PTEN PTEN s2369 sa1856 Active
cellular location: neuron c1

LOX
type: Protein
cellular location: neuron c1

RAS s1418 sa1080 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RAS
stoichiometric coefficient: 2.0

KNOWN_TRANSITION_OMITTED_LEFT__Abnormal_ceramide_accumulation-RIGHT__apoptosis-_re1017
type: Interaction
participant: Abnormal ceramide accumulation s2959 sa2331
participant: apoptosis s63 sa102
xref: KNOWN TRANSITION OMITTED

APBA1
type: Protein
cellular location: neuron c1

re202 s904 sa627 287
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PGK-RIGHT__PGK-_re202
control type: ACTIVATION
controller: estrogen

Ca2+
type: SmallMolecule
cellular location: neuron c1

AKT1
type: Protein
cellular location: neuron c1

CDK4
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__PUFA-RIGHT__LO-_re970
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re970 1592
participant stoichiometry: PARTICIPANT STOICHIOMETRY re970 1591
conversion direction: LEFT_TO_RIGHT
left: PUFA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: LO
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_CALM-RIGHT__CALM_Ca2_PLUS_-_re73
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 138
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 137
conversion direction: LEFT_TO_RIGHT
left: Ca2+
left: CALM
interaction type: HETERODIMER_ASSOCIATION
right: CALM-Ca2+
spontaneous: true
xref: HETERODIMER ASSOCIATION

re778 s3315 csa276 1248
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__TNF-RIGHT__TNF-_re778
control type: INHIBITION
controller: PPARA ligands-PPARA

PARTICIPANT STOICHIOMETRY re1214 1921
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1214 1922
type: Stoichiometry
physical entity: chemotaxis s3688 sa2602
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GTPase-RIGHT__GTPase-_re704
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re704 1141
participant stoichiometry: PARTICIPANT STOICHIOMETRY re704 1140
conversion direction: LEFT_TO_RIGHT
left: GTPase s2864 sa2269
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GTPase s3530 sa1567
xref: STATE TRANSITION

GGPP
type: SmallMolecule
cellular location: neuron c1

PTEN
type: Protein
cellular location: neuron c1

C2orf28 s105 sa345 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C2orf28
stoichiometric coefficient: 1.0

AP1 s3631 sa2535 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 2.0

AGER s2682 sa2425 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AGER
stoichiometric coefficient: 4.0

CASP1 s3723 sa2633 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__Ubiquinol-RIGHT__Q-_re222
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re222 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY re222 317
conversion direction: LEFT_TO_RIGHT
left: Ubiquinol
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Q
xref: TRANSPORT

KNOWN_TRANSITION_OMITTED_LEFT__NPD1-RIGHT__PPARG_-_re1294
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1294 2049
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1294 2050
conversion direction: LEFT_TO_RIGHT
left: NPD1
interaction type: KNOWN_TRANSITION_OMITTED
right: PPARG
xref: KNOWN TRANSITION OMITTED

GUCY1-NO
type: Complex
component: NO
component: GUCY1
cellular location: postsynaptic density c12

KNOWN_TRANSITION_OMITTED_LEFT__sphingolipid-RIGHT__Lipid_raft__increase-_re1348
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Lipid raft increase s3934 sa2852
controller: sphingolipid s3936 sa2854

DHA
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re309 470
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Ca2_PLUS_-RIGHT__superoxide_anion-_re967
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re967 1587
participant stoichiometry: PARTICIPANT STOICHIOMETRY re967 1588
conversion direction: LEFT_TO_RIGHT
left: Ca2+
interaction type: KNOWN_TRANSITION_OMITTED
right: superoxide anion
xref: KNOWN TRANSITION OMITTED

HMGB1 s3807 sa2716 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HMGB1 s3807 sa2716
stoichiometric coefficient: 1.0

VLDR-APOE
type: Complex
component: VLDR s3600 sa2504
component: APOE s470 sa315
cellular location: microglia c4

re880 s3192 csa245 1434
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__NFKB_responsive_genes-RIGHT__NFKB_responsive_genes-_re880
control type: INHIBITION
controller: NICD INPP5K CSHL1 HAT1 s3192 csa245

glucose s3899 sa2815 STOICHIOMETRY ID
type: Stoichiometry
physical entity: glucose
stoichiometric coefficient: 1.0

NOS s155 sa94 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOS
stoichiometric coefficient: 1.0

NTRK2 s2293 sa1786 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTRK2 s2293 sa1786
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re904 1497
type: Stoichiometry
physical entity: RPS6KB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re904 1498
type: Stoichiometry
physical entity: RPS6KB
stoichiometric coefficient: 1.0

IRS
type: Protein
feature: IRS IRS s2367 sa1851 Active
cellular location: neuron c1

STATE_TRANSITION_LEFT__Squalene-RIGHT__Oxydosqualene-_re353
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re353 570
participant stoichiometry: PARTICIPANT STOICHIOMETRY re353 571
conversion direction: LEFT_TO_RIGHT
left: Squalene s1100 sa804
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Oxydosqualene
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re309 468
type: Stoichiometry
physical entity: APP-APBB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re309 469
type: Stoichiometry
physical entity: APBB1-AICD
stoichiometric coefficient: 1.0

MAT1A s1523 sa1168 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAT1A
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__TF-RIGHT__TF-_re907
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re907 1504
participant stoichiometry: PARTICIPANT STOICHIOMETRY re907 1503
conversion direction: LEFT_TO_RIGHT
left: TF
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: TF
xref: TRANSPORT

KNOWN_TRANSITION_OMITTED_LEFT__7_dehydrocholesterol-RIGHT__cholesterol-_re355
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re355 575
participant stoichiometry: PARTICIPANT STOICHIOMETRY re355 574
conversion direction: LEFT_TO_RIGHT
left: 7-dehydrocholesterol
interaction type: KNOWN_TRANSITION_OMITTED
right: cholesterol s87 sa190
xref: KNOWN TRANSITION OMITTED

WISP1 s1790 sa1325 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WISP1
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__ceramide-RIGHT__ceramide_1_P-_re1149
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1149 1795
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1149 1794
conversion direction: LEFT_TO_RIGHT
left: ceramide
interaction type: KNOWN_TRANSITION_OMITTED
right: ceramide-1-P
xref: KNOWN TRANSITION OMITTED

KNOWN_TRANSITION_OMITTED_LEFT__Oligomeric_AmyloidB-RIGHT__oxidative_stress-_re1146
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: oxidative stress s1912 sa1432
controller: Oligomeric AmyloidB

Cell membrane
type: Pathway

COX2 s3835 sa2744 STOICHIOMETRY ID
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

NO
type: SmallMolecule
cellular location: default

Glyceraldehyde-P
type: SmallMolecule
cellular location: default

TRANSPORT_LEFT__sulfite-RIGHT__sulfite-_re484
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re484 796
participant stoichiometry: PARTICIPANT STOICHIOMETRY re484 795
conversion direction: LEFT_TO_RIGHT
left: sulfite
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: sulfite s1346 sa1010
xref: TRANSPORT

TNFA s3657 sa2574 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFA
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__NTF-_RTK-RIGHT__NTF_RTK-_re926
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re926 1536
participant stoichiometry: PARTICIPANT STOICHIOMETRY re926 1534
participant stoichiometry: PARTICIPANT STOICHIOMETRY re926 1535
conversion direction: LEFT_TO_RIGHT
left: NTF
left: RTK
interaction type: HETERODIMER_ASSOCIATION
right: NTF RTK s3178 csa250
spontaneous: true
xref: HETERODIMER ASSOCIATION

TRANSPORT_LEFT__NFKB1_RELA-RIGHT__NFKB1_RELA-_re1054
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1054 1655
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1054 1656
conversion direction: LEFT_TO_RIGHT
left: NFKB1 RELA s3308 csa269
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: NFKB1-RELA
xref: TRANSPORT

re901 s2610 sa2076 1487
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__HIF-RIGHT__HIF-_re901
control type: INHIBITION
controller: VHL

TLR4-DAMPs
type: Complex
component: TLR4
component: DAMPs s3733 sa2647
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re1236 1951
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1236 1950
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 1.0

PPARA ligands
type: SmallMolecule
cellular location: default

STX
type: Protein
feature: STX STX s2748 sa2215 Active
cellular location: neuron c1

RAS
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re344 550
type: Stoichiometry
physical entity: IPP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Unknown_CASP-RIGHT__Unknown_CASP-_re167
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re167 262
participant stoichiometry: PARTICIPANT STOICHIOMETRY re167 261
conversion direction: LEFT_TO_RIGHT
left: Unknown CASP s104 sa215
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Unknown CASP s104 sa218
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re326 502
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re326 500
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re326 501
type: Stoichiometry
physical entity: NADP PLUS s1045 sa752
stoichiometric coefficient: 1.0

STX
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re1309
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1309 2064
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1309 2063
conversion direction: LEFT_TO_RIGHT
left: CREB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CREB
xref: STATE TRANSITION

IRS
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re344 549
type: Stoichiometry
physical entity: Mevalonate PP
stoichiometric coefficient: 1.0

CHRN s2668 sa2124 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRN s2668 sa2124
stoichiometric coefficient: 1.0

CSNK1A1
type: Protein
feature: CSNK1A1 CSNK1A1 s1738 sa1277 Active
cellular location: neuron c1

neurodegeneration
type: Pathway

1,3 BPG s650 sa248 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 1,3 BPG s650 sa248
stoichiometric coefficient: 1.0

TLRs
type: Protein
cellular location: microglia c4

BH4
type: SmallMolecule
cellular location: neuron c1

RELA s2994 sa2356 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RELA
stoichiometric coefficient: 4.0

STK11
type: Protein
feature: STK11 STK11 s3462 sa2066 Active
cellular location: neuron c1

TPH
type: Protein
cellular location: neuron c1

GRN
type: Protein
cellular location: neuron c1

IL1B s3643 sa2553 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

Lanosterol
type: SmallMolecule
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__AICD-RIGHT__apoptosis-_re32
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: AICD

Oligomeric AmyloidB s2984 sa2347 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 30.0

STK11
type: Protein
cellular location: neuron c1

TRANSPORT_LEFT__estrogen-RIGHT__estrogen-_re274
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re274 408
participant stoichiometry: PARTICIPANT STOICHIOMETRY re274 409
conversion direction: LEFT_TO_RIGHT
left: estrogen
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: estrogen
xref: TRANSPORT

LPL s1848 sa1379 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LPL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re595 997
type: Stoichiometry
physical entity: AmyloidB s1136 sa89
stoichiometric coefficient: 10.0

HETERODIMER_ASSOCIATION_LEFT__TLR2-_DAMPs-RIGHT__TLR2_DAMPs-_re1256
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1256 1997
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1256 1996
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1256 1995
conversion direction: LEFT_TO_RIGHT
left: DAMPs
left: TLR2
interaction type: HETERODIMER_ASSOCIATION
right: TLR2-DAMPs
spontaneous: true
xref: HETERODIMER ASSOCIATION

TRANSPORT_LEFT__APOE-RIGHT__APOE-_re445
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re445 731
participant stoichiometry: PARTICIPANT STOICHIOMETRY re445 730
conversion direction: LEFT_TO_RIGHT
left: APOE
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: APOE s607 sa177
xref: TRANSPORT

STATE_TRANSITION_LEFT__H2O2-RIGHT__hydroxyl_radical-_re817
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re817 1319
participant stoichiometry: PARTICIPANT STOICHIOMETRY re817 1320
conversion direction: LEFT_TO_RIGHT
left: H2O2 s1924 sa1447
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: hydroxyl radical s2356 sa1839
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1317 2095
type: Stoichiometry
physical entity: AmyloidB-NMDAR
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3387 csa262
type: Stoichiometry
physical entity: LRP1 AmyloidB s3387 csa262
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1317 2094
type: Stoichiometry
physical entity: NMDAR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1317 2093
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

Unknown Wnt-target genes
type: RnaRegion
cellular location: DNAreplification c9

PARTICIPANT STOICHIOMETRY re595 996
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1170 1831
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1170 1830
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

FZD-WNT-LRP5/6
type: Complex
component: WNT
component: LRP5/6
component: FZD s286 sa484
cellular location: neuron c1

glutamate-GR
type: Complex
component: glutamate s1206 sa1497
component: GR
cellular location: postsynaptic density c12

HETERODIMER_ASSOCIATION_LEFT__cholesterol-_APOE-RIGHT__APOE_cholesterol-_re150
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re150 234
participant stoichiometry: PARTICIPANT STOICHIOMETRY re150 235
participant stoichiometry: PARTICIPANT STOICHIOMETRY re150 236
conversion direction: LEFT_TO_RIGHT
left: cholesterol
left: APOE
interaction type: HETERODIMER_ASSOCIATION
right: APOE-cholesterol
spontaneous: true
xref: HETERODIMER ASSOCIATION

APAF1
type: Protein
feature: APAF1 APAF1 s83 sa170 Active
cellular location: neuron c1

PE
type: SmallMolecule
cellular location: neuron c1

STATE_TRANSITION_LEFT__MAP2K-RIGHT__MAP2K-_re813
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re813 1309
participant stoichiometry: PARTICIPANT STOICHIOMETRY re813 1308
conversion direction: LEFT_TO_RIGHT
left: MAP2K
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAP2K
xref: STATE TRANSITION

STOICHIOMETRY ID s3187 csa173
type: Stoichiometry
physical entity: TNFRSF1A TRADD TRAF2 RIP s3187 csa173
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__ACTA1-RIGHT__ACTA1-_re447
type: TemplateReaction
participant: ACTA1 s1317 sa980
participant: ACTA1 s1316 sa979
product: ACTA1 s1317 sa980
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

ERN1 s187 sa117 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ERN1
stoichiometric coefficient: 2.0

STOICHIOMETRY ID s3237 csa140
type: Stoichiometry
physical entity: FTH-ACO1-IREB2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__superoxide-RIGHT__superoxide_anion-_re818
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re818 1322
participant stoichiometry: PARTICIPANT STOICHIOMETRY re818 1321
conversion direction: LEFT_TO_RIGHT
left: superoxide s2357 sa1840
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: superoxide anion
xref: STATE TRANSITION

re1120 s2090 sa1608 1757
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__GSK3B-RIGHT__GSK3B-_re1120
control type: INHIBITION
controller: AKT1

F2A isoprostanes s1923 sa1446 STOICHIOMETRY ID
type: Stoichiometry
physical entity: F2A-isoprostanes
stoichiometric coefficient: 1.0

Unknown receptor s2639 sa2098 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Unknown receptor s2639 sa2098
stoichiometric coefficient: 3.0

HETERODIMER_ASSOCIATION_LEFT__APP_SORL1-_VPS29_VPS35_SNX_VPS26A-RIGHT__APP_SORL1_VPS29_VPS35_SNX_VPS26A-_re78
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 148
conversion direction: LEFT_TO_RIGHT
left: APP SORL1 s3275 csa13
left: VPS29-VPS35-SNX-VPS26A
interaction type: HETERODIMER_ASSOCIATION
right: APP SORL1 VPS29 VPS35 SNX VPS26A s3277 csa12
spontaneous: true
xref: HETERODIMER ASSOCIATION

CBS s1373 sa1043 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CBS
stoichiometric coefficient: 1.0

ADCY10 s1999 sa908 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADCY10
stoichiometric coefficient: 1.0

JAK2
type: Protein
feature: JAK2 JAK2 s3454 sa1522 Active
cellular location: neuron c1

CD4
type: Protein

ABL s2726 sa2198 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ABL s2726 sa2198
stoichiometric coefficient: 1.0

CASP9 s450 sa127 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP9
stoichiometric coefficient: 1.0

Lipid peroxidation
type: Pathway

STOICHIOMETRY ID s3296 csa210
type: Stoichiometry
physical entity: PPARG RXR unkown repressor s3296 csa210
stoichiometric coefficient: 1.0

NR1H
type: Protein
cellular location: nucleus c3

ROS
type: SmallMolecule
cellular location: neuron c1

STOICHIOMETRY ID s3326 csa20
type: Stoichiometry
physical entity: APP-APBB1
stoichiometric coefficient: 1.0

O2
type: SmallMolecule
cellular location: mitochondria c7

CASP12 s1444 sa120 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP12
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re937
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re937 1563
participant stoichiometry: PARTICIPANT STOICHIOMETRY re937 1562
conversion direction: LEFT_TO_RIGHT
left: Ca2+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Ca2+
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re849 1384
type: Stoichiometry
physical entity: ITAM
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SRC-RIGHT__SRC-_re489
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re489 807
participant stoichiometry: PARTICIPANT STOICHIOMETRY re489 808
conversion direction: LEFT_TO_RIGHT
left: SRC
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: SRC
xref: STATE TRANSITION

STOICHIOMETRY ID s3609 csa288
type: Stoichiometry
physical entity: P2X7-ATP
stoichiometric coefficient: 1.0

IL1 s1308 sa970 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1
stoichiometric coefficient: 1.0

Apoptosis
type: Pathway

STX s2748 sa2215 STOICHIOMETRY ID
type: Stoichiometry
physical entity: STX
stoichiometric coefficient: 1.0

MAPK14
type: Protein
cellular location: MAPK cascade c6

NAD PLUS s1050 sa757 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 2.0

HAT1 s2574 sa2027 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HAT1
stoichiometric coefficient: 4.0

ATRA s732 sa418 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATRA s732 sa418
stoichiometric coefficient: 1.0

A2M s2972 sa2345 STOICHIOMETRY ID
type: Stoichiometry
physical entity: A2M
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re546 923
type: Stoichiometry
physical entity: AmyloidB CLU s3243 csa148
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re546 922
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

ITPR-IP3
type: Complex
component: ITPR
component: IP3
cellular location: endoplasmic reticulum ER c5

PARTICIPANT STOICHIOMETRY re546 921
type: Stoichiometry
physical entity: CLU
stoichiometric coefficient: 1.0

LIN7 s2750 sa2217 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LIN7
stoichiometric coefficient: 1.0

Met sulfide radical cation
type: SmallMolecule
cellular location: neuron c1

WISP1
type: Protein
feature: WISP1 WISP1 s1790 sa1325 Active
cellular location: neuron c1

superoxide anion s2702 sa2179 STOICHIOMETRY ID
type: Stoichiometry
physical entity: superoxide anion
stoichiometric coefficient: 1.0

RPS6KB s2613 sa2081 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RPS6KB
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__APOE-RIGHT__APOE-_re443
type: TemplateReaction
participant: APOE
participant: APOE s1313 sa976
product: APOE
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

KNOWN_TRANSITION_OMITTED_LEFT__DAMPs-RIGHT__NALP1-_re1267
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1267 2004
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1267 2003
conversion direction: LEFT_TO_RIGHT
left: DAMPs
interaction type: KNOWN_TRANSITION_OMITTED
right: NALP1
xref: KNOWN TRANSITION OMITTED

CD3G s2455 sa1918 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD3G
stoichiometric coefficient: 1.0

RAGE s3803 sa2715 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RAGE
stoichiometric coefficient: 1.0

JAK2
type: Protein
cellular location: neuron c1

PIK3 s910 sa632 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PIK3
stoichiometric coefficient: 1.0

hypotaurine
type: SmallMolecule
cellular location: neuron c1

TRAF2
type: Protein

L-Cys
type: SmallMolecule
cellular location: mitochondria c7

PARTICIPANT STOICHIOMETRY re326 499
type: Stoichiometry
physical entity: 5ADHP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NFKB_responsive_genes-RIGHT__NFKB_responsive_genes-_re880
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re880 1438
participant stoichiometry: PARTICIPANT STOICHIOMETRY re880 1437
conversion direction: LEFT_TO_RIGHT
left: NFKB responsive genes
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NFKB responsive genes
xref: STATE TRANSITION

TRANSPORT_LEFT__AmyloidB_CLU-RIGHT__Unknown_transportation-_re1138
type: Control
xref: TRANSPORT
controlled: Unknown transportation
controller: AmyloidB CLU s3243 csa148

FOXO
type: Protein
cellular location: neuron c1

ZAP70 s3023 sa2373 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ZAP70
stoichiometric coefficient: 1.0

PLA2G4A s3579 sa2487 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLA2G4A s3579 sa2487
stoichiometric coefficient: 1.0

60S s2832 sa1150 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 60S s2832 sa1150
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re901 1488
type: Stoichiometry
physical entity: HIF s2609 sa2074
stoichiometric coefficient: 1.0

Insulin-IR
type: Complex
component: insulin s3887 sa2807
component: Insulin receptor
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re901 1489
type: Stoichiometry
physical entity: HIF s2609 sa2075
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NFKB-RIGHT__NFKB-_re1127
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1127 1766
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1127 1767
conversion direction: LEFT_TO_RIGHT
left: NFKB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NFKB
xref: STATE TRANSITION

Plasmin s1010 sa720 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

sa2546 degraded s3674 sa2588 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sa2546_degraded
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__MAPT_-RIGHT__axonal_transport-_re732
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: axonal transport
controller: MAPT s3448 sa85

FOXO
type: Protein
feature: FOXO FOXO s3457 sa1853 Active
cellular location: neuron c1

INPP5K
type: Protein

PARTICIPANT STOICHIOMETRY re352 567
type: Stoichiometry
physical entity: Farnesyl PP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re352 568
type: Stoichiometry
physical entity: Dolichol s1106 sa810
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CASP1-RIGHT__CASP1-_re1236
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1236 1951
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1236 1950
conversion direction: LEFT_TO_RIGHT
left: CASP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CASP1
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__GRN-RIGHT__Modulation_of_gene_expression_-_re144
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Modulation of gene expression
controller: GRN

IL1B
type: DnaRegion
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re478 777
type: Stoichiometry
physical entity: sulfite s1346 sa1010
stoichiometric coefficient: 1.0

APC
type: Protein
cellular location: neuron c1

PSMD9
type: Protein
cellular location: neuron c1

LRP5/6
type: Protein
cellular location: neuron c1

phospholipase C s3682 sa2596 STOICHIOMETRY ID
type: Stoichiometry
physical entity: phospholipase C
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re478 774
type: Stoichiometry
physical entity: thiosulfate
stoichiometric coefficient: 1.0

APBB1 s2708 sa2185 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APBB1
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re478 776
type: Stoichiometry
physical entity: GSSG+HS-
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re478 775
type: Stoichiometry
physical entity: 2GSH
stoichiometric coefficient: 1.0

BAD
type: Protein
cellular location: neuron c1

PPARG s2070 sa1588 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARG
stoichiometric coefficient: 1.0

Na+
type: SmallMolecule
cellular location: postsynaptic density c12

WISP1
type: Protein
cellular location: neuron c1

PPARA ligands s2226 sa1730 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARA ligands
stoichiometric coefficient: 1.0

Unknown Wnt target genes s318 sa464 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Unknown Wnt-target genes
stoichiometric coefficient: 1.0

UDP s3919 sa2836 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UDP s3919 sa2836
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1184 1868
type: Stoichiometry
physical entity: PGE2
stoichiometric coefficient: 1.0

M
type: Pathway

PARTICIPANT STOICHIOMETRY re1184 1867
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

C3B s1283 sa943 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C3B
stoichiometric coefficient: 1.0

RAF1 s1419 sa1081 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

Unknown Wnt-target genes
type: DnaRegion
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re759 1227
type: Stoichiometry
physical entity: ATG12-ATG6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re759 1226
type: Stoichiometry
physical entity: ATG16
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re759 1228
type: Stoichiometry
physical entity: ATG12-ATG5-ATG16
stoichiometric coefficient: 1.0

NALP1
type: Protein
feature: NALP1 NALP1 s3784 sa2691 Active
cellular location: neuron c1

oxyradical s2694 sa2169 STOICHIOMETRY ID
type: Stoichiometry
physical entity: oxyradical
stoichiometric coefficient: 1.0

UBA1-UB
type: Complex
component: UBA1
component: UB
cellular location: neuron c1

mutant PSEN-CIB1
type: Complex
component: mutant PSEN s1437 sa1094
component: CIB1
cellular location: endoplasmic reticulum ER c5

STATE_TRANSITION_LEFT__N_APP-RIGHT__DR6-_re1196
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1196 1884
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1196 1883
conversion direction: LEFT_TO_RIGHT
left: N APP s3656 sa2571
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: DR6 s3654 sa2568
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re78 147
type: Stoichiometry
physical entity: VPS29-VPS35-SNX-VPS26A
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3369 csa4
type: Stoichiometry
physical entity: LRP1 AmyloidB APOE LPL s3369 csa4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re78 146
type: Stoichiometry
physical entity: APP SORL1 s3275 csa13
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RYR3-RIGHT__RYR3-_re842
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re842 1372
participant stoichiometry: PARTICIPANT STOICHIOMETRY re842 1373
conversion direction: LEFT_TO_RIGHT
left: RYR3 s3145 sa1891
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: RYR3
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re78 148
type: Stoichiometry
physical entity: APP SORL1 VPS29 VPS35 SNX VPS26A s3277 csa12
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__RARE_target_genes-RIGHT__synaptic_plasticity-_re1001
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: synaptic plasticity
controller: RARE target genes

AmyloidB s293 sa313 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 32.0

STATE_TRANSITION_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re1313
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1313 2080
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1313 2081
conversion direction: LEFT_TO_RIGHT
left: Na+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Na+
xref: STATE TRANSITION

CAV1 s1617 sa1242 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CAV1 s1617 sa1242
stoichiometric coefficient: 2.0

TLR
type: Protein
cellular location: microglia c4

HMGB1 s3470 sa2449 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HMGB1
stoichiometric coefficient: 1.0

WNT3A s2055 sa1772 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT3A
stoichiometric coefficient: 1.0

NALP1
type: Protein
cellular location: neuron c1

GTP s2495 sa1965 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 2.0

KNOWN_TRANSITION_OMITTED_LEFT__G1-RIGHT__S-_re1140
type: Interaction
participant: S
participant: G1
xref: KNOWN TRANSITION OMITTED

STOICHIOMETRY ID s3295 csa209
type: Stoichiometry
physical entity: PPARG-RXR-unkown PPARG ligand
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__recruitment_of_microglia-_re99
type: Interaction
participant: Microglia Activation
participant: recruitment of microglia
xref: KNOWN TRANSITION OMITTED

BACE1 s1276 sa939 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BACE1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__NICD_INPP5K_CSHL1_HAT1-_LAG3-RIGHT__NICD_CSHL1_LAG3_HAT1-_INPP5K-_re883
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re883 1442
participant stoichiometry: PARTICIPANT STOICHIOMETRY re883 1443
participant stoichiometry: PARTICIPANT STOICHIOMETRY re883 1444
participant stoichiometry: PARTICIPANT STOICHIOMETRY re883 1445
conversion direction: LEFT_TO_RIGHT
left: NICD INPP5K CSHL1 HAT1 s3192 csa245
left: LAG3
interaction type: HETERODIMER_ASSOCIATION
right: NICD-CSHL1-LAG3-HAT1
right: INPP5K
spontaneous: true
xref: HETERODIMER ASSOCIATION

TNFRSF21
type: Protein
feature: TNFRSF21 TNFRSF21 s505 sa384 Active

PARTICIPANT STOICHIOMETRY re1119 1756
type: Stoichiometry
physical entity: s3080
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1119 1755
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3179 csa5
type: Stoichiometry
physical entity: TNFRSF1A-FADD-CASP8
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__peroxynitrite__ONOO__-RIGHT__apoptosis-_re52
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: peroxynitrite (ONOO-)

ULK1
type: Protein

ALLOP
type: SmallMolecule
cellular location: default

APP
type: Protein
cellular location: neuron c1

Fe
type: SmallMolecule

MPST s1352 sa1018 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MPST
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3236 csa143
type: Stoichiometry
physical entity: FYH PCBP1 PCBP2 s3236 csa143
stoichiometric coefficient: 1.0

CIB1 s2432 sa1903 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CIB1
stoichiometric coefficient: 1.0

FTH
type: RnaRegion
cellular location: neuron c1

GSK3B s62 sa2435 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

AmyloidB s1546 sa1194 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

AKT1 s2090 sa1608 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re796 1282
type: Stoichiometry
physical entity: NGF
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re796 1283
type: Stoichiometry
physical entity: NTRK1 s1017 sa728
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__C1Q-_AmyloidB1_42-RIGHT__AmyloidB1_42_C1Q-_re96
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re96 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY re96 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY re96 162
conversion direction: LEFT_TO_RIGHT
left: AmyloidB1-42
left: C1Q
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB1-42-C1Q
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re374 621
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re374 620
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re831 1340
type: Stoichiometry
physical entity: IFI44 s2790 sa1858
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__ATG13_ATG11_ULK1_ATG17-RIGHT__autophagy_induction-_re751
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: autophagy induction
controller: ATG13-ATG11-ULK1-ATG17

PARTICIPANT STOICHIOMETRY re427 712
type: Stoichiometry
physical entity: AmyloidB1 42 s1280 sa944
stoichiometric coefficient: 5.0

STATE_TRANSITION_LEFT__SMPD2-RIGHT__SMPD2-_re526
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re526 875
participant stoichiometry: PARTICIPANT STOICHIOMETRY re526 874
conversion direction: LEFT_TO_RIGHT
left: SMPD2 s1506 sa1153
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: SMPD2 s1506 sa1152
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re427 711
type: Stoichiometry
physical entity: C3B s3489 sa946
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re427 713
type: Stoichiometry
physical entity: C1Q-AmyloidB1-42-C3B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re427 710
type: Stoichiometry
physical entity: C1Q
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__C1Q-_C3B-_AmyloidB1_42-RIGHT__C1Q_AmyloidB1_42_C3B-_re427
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re427 712
participant stoichiometry: PARTICIPANT STOICHIOMETRY re427 711
participant stoichiometry: PARTICIPANT STOICHIOMETRY re427 713
participant stoichiometry: PARTICIPANT STOICHIOMETRY re427 710
conversion direction: LEFT_TO_RIGHT
left: C3B s3489 sa946
left: AmyloidB1 42 s1280 sa944
left: C1Q
interaction type: HETERODIMER_ASSOCIATION
right: C1Q-AmyloidB1-42-C3B
spontaneous: true
xref: HETERODIMER ASSOCIATION

Ca2 PLUS s3054 sa2401 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Ca2 PLUS s3054 sa2401
stoichiometric coefficient: 1.0

superoxide anion s2354 sa1836 STOICHIOMETRY ID
type: Stoichiometry
physical entity: superoxide anion
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re112 184
type: Stoichiometry
physical entity: HPETE s402 sa164
stoichiometric coefficient: 1.0

AP1 s2353 sa1833 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3815 csa313
type: Stoichiometry
physical entity: humanin FPRL1 s3815 csa313
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re112 183
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re112 182
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__NGFR_NGF-RIGHT__differentiation-_re380
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: differentiation
controller: NGFR-NGF

STOICHIOMETRY ID s3374 csa99
type: Stoichiometry
physical entity: APBB1-KAT5-SET-AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1222 1935
type: Stoichiometry
physical entity: SRA2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1222 1934
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB_fibril-_AGER-RIGHT__AGER_AmyloidB_fibril-_re1111
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1111 1743
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1111 1744
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1111 1745
conversion direction: LEFT_TO_RIGHT
left: AGER
left: AmyloidB fibril s2665 sa2153
interaction type: HETERODIMER_ASSOCIATION
right: AGER-AmyloidB fibril
spontaneous: true
xref: HETERODIMER ASSOCIATION

CREB s3845 sa2755 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

csa30_degraded
type: PhysicalEntity
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re869 1421
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re869 1423
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re869 1422
type: Stoichiometry
physical entity: GTPase s2864 sa2269
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1222 1936
type: Stoichiometry
physical entity: SRA2-AmyloidB
stoichiometric coefficient: 1.0

PLCG
type: Protein
feature: PLCG PLCG s2946 sa2320 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re869 1424
type: Stoichiometry
physical entity: GTPase
stoichiometric coefficient: 1.0

ERN1
type: Protein
feature: ERN1 ERN1 s187 sa117 rs1
feature: ERN1 ERN1 s187 sa117 Active
cellular location: endoplasmic reticulum ER c5

STATE_TRANSITION_LEFT__SMPD2-RIGHT__SMPD2-_re517
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re517 856
participant stoichiometry: PARTICIPANT STOICHIOMETRY re517 857
conversion direction: LEFT_TO_RIGHT
left: SMPD2 s1506 sa1152
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: SMPD2 s1506 sa1153
xref: STATE TRANSITION

TRANSPORT_LEFT__C3A_AmyloidB1_42-RIGHT__C3A_AmyloidB1_42-_re429
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re429 720
participant stoichiometry: PARTICIPANT STOICHIOMETRY re429 719
conversion direction: LEFT_TO_RIGHT
left: C3A-AmyloidB1-42
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: C3A AmyloidB1 42 s3503 csa124
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re831 1339
type: Stoichiometry
physical entity: IFI44 s2790 sa1857
stoichiometric coefficient: 1.0

UBA1
type: Protein

re369 s1135 sa835 606
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__PSPHL-RIGHT__PSPHL-_re369
control type: INHIBITION
controller: IL11

STATE_TRANSITION_LEFT__NFKB-RIGHT__NFKB-_re1172
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1172 1841
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1172 1840
conversion direction: LEFT_TO_RIGHT
left: NFKB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NFKB
xref: STATE TRANSITION

ST8SIA1
type: DnaRegion
cellular location: nucleus c3

STOICHIOMETRY ID s3306 csa267
type: Stoichiometry
physical entity: AmyloidB A2M s3306 csa267
stoichiometric coefficient: 1.0

proinflammation
type: Pathway

STATE_TRANSITION_LEFT__PFK-RIGHT__PFK-_re199
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re199 276
participant stoichiometry: PARTICIPANT STOICHIOMETRY re199 277
conversion direction: LEFT_TO_RIGHT
left: PFK s3487 sa244
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PFK
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__PGGT1B-RIGHT__PGGT1B-_re861
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re861 1403
participant stoichiometry: PARTICIPANT STOICHIOMETRY re861 1404
conversion direction: LEFT_TO_RIGHT
left: PGGT1B s2387 sa1874
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PGGT1B
xref: STATE TRANSITION

40S s1462 sa1119 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 40S
stoichiometric coefficient: 1.0

ERN1
type: Protein
cellular location: endoplasmic reticulum ER c5

C83
type: Protein
cellular location: neuron c1

IDE
type: Protein
cellular location: neuron c1

CDKN1A
type: Protein
feature: CDKN1A CDKN1A s74 sa138 Active
cellular location: neuron c1

L-Cys
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re932 1551
type: Stoichiometry
physical entity: ATP1 s3483 sa2131
stoichiometric coefficient: 1.0

60S
type: Protein
cellular location: neuron c1

GABARAPL2 s2214 sa1721 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GABARAPL2
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re932 1550
type: Stoichiometry
physical entity: ATP1 s3483 sa2130
stoichiometric coefficient: 1.0

LDLR s1847 sa1378 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LDLR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re963 1577
type: Stoichiometry
physical entity: H2O2 s1924 sa1447
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re963 1578
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

CASP1
type: Protein
cellular location: neuron c1

Epoxidation s3830 sa2739 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Epoxidation s3830 sa2739
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1240 1963
type: Stoichiometry
physical entity: RIPK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1240 1964
type: Stoichiometry
physical entity: RIPK2
stoichiometric coefficient: 1.0

ROS s3063 sa2419 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

SRB1
type: Protein
cellular location: astrocyte c2

IDE s69 sa60 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IDE
stoichiometric coefficient: 1.0

L Cysteinesulfinate s1321 sa984 STOICHIOMETRY ID
type: Stoichiometry
physical entity: L Cysteinesulfinate s1321 sa984
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3232 csa135
type: Stoichiometry
physical entity: APP PCBP2 PCBP1 FMR1 60S 40S s3232 csa135
stoichiometric coefficient: 1.0

FKBP8 s3460 sa2055 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FKBP8
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__CASP2-RIGHT__Mitochondrial_dysfunction-_re586
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Mitochondrial dysfunction s462 sa81
controller: CASP2 s1761 sa1302

re826 s2369 sa1856 1326
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__IGF1R-RIGHT__IGF1R-_re826
control type: INHIBITION
controller: PTEN

IRS s2367 sa1850 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

CTH
type: Protein
cellular location: neuron c1

CASP1
type: Protein
feature: CASP1 CASP1 s1892 sa1415 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re425 708
type: Stoichiometry
physical entity: PPARG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re425 709
type: Stoichiometry
physical entity: TIMP1
stoichiometric coefficient: 1.0

re892 s3459 sa2054 1467
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__FKBP8-RIGHT__FKBP8-_re892
control type: INHIBITION
controller: RHEB

FDPS
type: Protein
feature: FDPS FDPS s1098 sa801 Active
cellular location: neuron c1

TSC s3458 sa2052 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TSC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re334 527
type: Stoichiometry
physical entity: ALLOP s2869 sa2274
stoichiometric coefficient: 1.0

AMPAR s3851 sa2770 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AMPAR s3851 sa2770
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re334 526
type: Stoichiometry
physical entity: ALLOP s3565 sa2273
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__ST8SIA1-RIGHT__ST8SIA1-_re713
type: TemplateReaction
participant: ST8SIA1
participant: ST8SIA1 s2077 sa1596
product: ST8SIA1 s2077 sa1596
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

HRK s1906 sa1428 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HRK s1906 sa1428
stoichiometric coefficient: 1.0

MAPK8
type: Protein
cellular location: MAPK cascade c6

TCA cycle
type: Pathway

STOICHIOMETRY ID s3305 csa265
type: Stoichiometry
physical entity: AmyloidB-A2M
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3355 csa65
type: Stoichiometry
physical entity: UBE2M NEDD8 s3355 csa65
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re634 1065
type: Stoichiometry
physical entity: BAX s1913 sa1433
stoichiometric coefficient: 1.0

MAP2K s2352 sa1831 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP2K
stoichiometric coefficient: 1.0

Plasmin
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re634 1066
type: Stoichiometry
physical entity: BAX s1913 sa1434
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB1_42-_APOE-RIGHT__AmyloidB1_42_APOE-_re131
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re131 202
participant stoichiometry: PARTICIPANT STOICHIOMETRY re131 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re131 200
conversion direction: LEFT_TO_RIGHT
left: APOE s607 sa177
left: AmyloidB1-42
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB1-42-APOE
spontaneous: true
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__IFI44-RIGHT__IFI44-_re831
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re831 1339
participant stoichiometry: PARTICIPANT STOICHIOMETRY re831 1340
conversion direction: LEFT_TO_RIGHT
left: IFI44 s2790 sa1857
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IFI44 s2790 sa1858
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re694 1116
type: Stoichiometry
physical entity: sa64 degraded s768 sa1543
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__TNF-RIGHT__TNF-_re1279
type: TemplateReaction
participant: TNF
participant: TNF s3796 sa2708
product: TNF
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

DAB1
type: Protein
feature: DAB1 DAB1 s2092 sa1614 Active
cellular location: neuron c1

PSD95 s3855 sa2776 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSD95
stoichiometric coefficient: 1.0

CASK
type: Protein
feature: CASK CASK s2747 sa2213 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re694 1115
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re920 1531
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re920 1532
type: Stoichiometry
physical entity: Unknown receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re920 1533
type: Stoichiometry
physical entity: unkown receptor TNF s3288 csa249
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3178 csa250
type: Stoichiometry
physical entity: NTF RTK s3178 csa250
stoichiometric coefficient: 1.0

NICD-CSHL1-LAG3-HAT1
type: Complex
component: HAT1
component: CSHL1
component: NICD
component: LAG3
cellular location: nucleus c3

MMP9
type: Protein
cellular location: default

ATP s3611 sa2513 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Mg2+
type: SmallMolecule
cellular location: default

Delta
type: Protein
cellular location: Neuron No.2 c10

OXCT1
type: Protein
feature: OXCT1 OXCT1 s678 sa272 Active
cellular location: neuron c1

CASP9
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re487 805
type: Stoichiometry
physical entity: metal ligand Cu s3223 csa126
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__STXBP1-RIGHT__STXBP1-_re980
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re980 1615
participant stoichiometry: PARTICIPANT STOICHIOMETRY re980 1614
conversion direction: LEFT_TO_RIGHT
left: STXBP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: STXBP1
xref: STATE TRANSITION

RIPK2 s3728 sa2641 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RIPK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re928 1541
type: Stoichiometry
physical entity: CHRN
stoichiometric coefficient: 1.0

IRF s3717 sa2624 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IRF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re487 804
type: Stoichiometry
physical entity: metal ligand Cu s3224 csa125
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re928 1542
type: Stoichiometry
physical entity: CHRN-AmyloidB
stoichiometric coefficient: 1.0

acetylcholine s106 sa220 STOICHIOMETRY ID
type: Stoichiometry
physical entity: acetylcholine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ZAP70-RIGHT__ZAP70-_re1063
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1063 1675
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1063 1674
conversion direction: LEFT_TO_RIGHT
left: ZAP70
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ZAP70
xref: STATE TRANSITION

BACE1 s3945 sa2863 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BACE1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re928 1540
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

NALP s3726 sa2639 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NALP
stoichiometric coefficient: 1.0

RAGE-AmyloidB
type: Complex
component: RAGE
component: AmyloidB
cellular location: microglia c4

STATE_TRANSITION_LEFT__NOS-RIGHT__NOS-_re406
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re406 680
participant stoichiometry: PARTICIPANT STOICHIOMETRY re406 679
conversion direction: LEFT_TO_RIGHT
left: NOS s1241 sa911
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NOS s1241 sa912
xref: STATE TRANSITION

TRANSLATION_LEFT__IL1-RIGHT__IL1B-_re440
type: TemplateReaction
participant: IL1
participant: IL1B
product: IL1B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

STOICHIOMETRY ID s3252 csa11
type: Stoichiometry
physical entity: ITPR-IP3
stoichiometric coefficient: 1.0

AP1
type: Protein
cellular location: astrocyte c2

IREB2 s1484 sa1138 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IREB2 s1484 sa1138
stoichiometric coefficient: 1.0

NFKB responsive genes
type: Protein
cellular location: nucleus c3

IL6 s3468 sa2452 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

s3839 s3839 sa2748 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s3839 s3839 sa2748
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re513 840
type: Stoichiometry
physical entity: FTH-ACO1-IREB2-Fe
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3225 csa208
type: Stoichiometry
physical entity: IL6-IL6R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re513 841
type: Stoichiometry
physical entity: Fe
stoichiometric coefficient: 1.0

GlcNAc6P
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re513 842
type: Stoichiometry
physical entity: FTH-ACO1-IREB2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re314 483
type: Stoichiometry
physical entity: MMP9
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re314 482
type: Stoichiometry
physical entity: proMMP9
stoichiometric coefficient: 1.0

oxidase s3642 sa2548 STOICHIOMETRY ID
type: Stoichiometry
physical entity: oxidase
stoichiometric coefficient: 1.0

ASC
type: Protein
cellular location: microglia c4

DAB1
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__TNF-_TNFRSF1A-RIGHT__TNFRSF1A_TNF-_re781
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re781 1256
participant stoichiometry: PARTICIPANT STOICHIOMETRY re781 1257
participant stoichiometry: PARTICIPANT STOICHIOMETRY re781 1255
conversion direction: LEFT_TO_RIGHT
left: TNF
left: TNFRSF1A s2237 sa67
interaction type: HETERODIMER_ASSOCIATION
right: TNFRSF1A-TNF
spontaneous: true
xref: HETERODIMER ASSOCIATION

IREB2
type: Protein

PCBP1
type: Protein
cellular location: neuron c1

CASK
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__UNC13A-_NT-_APP-RIGHT__vesicle_transport-_re537
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re537 906
participant stoichiometry: PARTICIPANT STOICHIOMETRY re537 905
participant stoichiometry: PARTICIPANT STOICHIOMETRY re537 904
participant stoichiometry: PARTICIPANT STOICHIOMETRY re537 903
conversion direction: LEFT_TO_RIGHT
left: UNC13A
left: NT s1542 sa1188
left: APP s1535 sa1182
interaction type: HETERODIMER_ASSOCIATION
right: vesicle transport s1537 csa145
spontaneous: true
xref: HETERODIMER ASSOCIATION

C8
type: Protein

FNTA
type: Protein
feature: FNTA FNTA s2401 sa1883 Active
cellular location: neuron c1

IL6
type: Protein
feature: IL6 IL6 s3509 sa1751 Active
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__PPARG-RIGHT__TIMP1-_re425
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re425 708
participant stoichiometry: PARTICIPANT STOICHIOMETRY re425 709
conversion direction: LEFT_TO_RIGHT
left: PPARG
interaction type: KNOWN_TRANSITION_OMITTED
right: TIMP1
xref: KNOWN TRANSITION OMITTED

NR1H
type: Protein
feature: NR1H NR1H s526 sa388 Active

PEBP1 s2137 sa1651 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PEBP1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__UB-_CTNNB1-RIGHT__CTNNB1-_re695
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re695 1120
participant stoichiometry: PARTICIPANT STOICHIOMETRY re695 1121
participant stoichiometry: PARTICIPANT STOICHIOMETRY re695 1119
conversion direction: LEFT_TO_RIGHT
left: CTNNB1 s2840 sa461
left: UB s937 sa658
interaction type: HETERODIMER_ASSOCIATION
right: CTNNB1
xref: HETERODIMER ASSOCIATION

CD93
type: Protein
feature: CD93 CD93 s345 sa356 Active

Exendin4
type: Protein
cellular location: neuron c1

5'GMP
type: SmallMolecule
cellular location: postsynaptic density c12

STATE_TRANSITION_LEFT__L_Cys-RIGHT__L_Cystine-_re455
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re455 751
participant stoichiometry: PARTICIPANT STOICHIOMETRY re455 750
conversion direction: LEFT_TO_RIGHT
left: L-Cys
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: L-Cystine
xref: STATE TRANSITION

GRIA s3003 sa2358 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GRIA
stoichiometric coefficient: 1.0

GRI
type: Protein
feature: GRI GRI s3008 sa2159 Active

GlcNH26P s3901 sa2819 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GlcNH26P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1185 1870
type: Stoichiometry
physical entity: ATP s3122 sa2127
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1185 1869
type: Stoichiometry
physical entity: ATP s890 sa613
stoichiometric coefficient: 1.0

VEGFA
type: Protein
cellular location: neuron c1

IL1B s3626 sa2530 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re536 901
type: Stoichiometry
physical entity: BACE s1534 sa1181
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re536 902
type: Stoichiometry
physical entity: BACE
stoichiometric coefficient: 1.0

glutamate s1206 sa1497 STOICHIOMETRY ID
type: Stoichiometry
physical entity: glutamate s1206 sa1497
stoichiometric coefficient: 8.0

PSENEN
type: Protein

CHRNA4 s2005 sa1513 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRNA4 s2005 sa1513
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1026 1639
type: Stoichiometry
physical entity: AmyloidB CLU s3244 csa263
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1026 1638
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1026 1637
type: Stoichiometry
physical entity: CLU
stoichiometric coefficient: 1.0

NO s159 sa97 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NO s159 sa97
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__HIF-RIGHT__HIF-_re901
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re901 1488
participant stoichiometry: PARTICIPANT STOICHIOMETRY re901 1489
conversion direction: LEFT_TO_RIGHT
left: HIF s2609 sa2074
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HIF s2609 sa2075
xref: STATE TRANSITION

STOICHIOMETRY ID s3313 csa273
type: Stoichiometry
physical entity: GRI-glutamate
stoichiometric coefficient: 1.0

re65 s3025 sa2376 111
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ATF6-RIGHT__ATF6-_re65
control type: INHIBITION
controller: mutant PSEN

C8
type: Protein
cellular location: default

GAP s2500 sa1969 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GAP s2500 sa1969
stoichiometric coefficient: 1.0

VEGFA
type: Protein
feature: VEGFA VEGFA s2611 sa2078 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re127 192
type: Stoichiometry
physical entity: APOE-LPL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re127 193
type: Stoichiometry
physical entity: PSPHL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re880 1438
type: Stoichiometry
physical entity: NFKB responsive genes
stoichiometric coefficient: 1.0

LRP5 6 s1743 sa1278 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP5/6
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re127 194
type: Stoichiometry
physical entity: AmyloidB1-40
stoichiometric coefficient: 1.0

Zn2+
type: SmallMolecule
cellular location: default

PARTICIPANT STOICHIOMETRY re127 195
type: Stoichiometry
physical entity: LRP1 AmyloidB APOE LPL s3369 csa4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re880 1437
type: Stoichiometry
physical entity: NFKB responsive genes
stoichiometric coefficient: 1.0

BTRC s2041 sa1555 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BTRC
stoichiometric coefficient: 1.0

DAG s2374 sa2281 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 2.0

IDE
type: Protein
feature: IDE IDE s69 sa2796 Active
cellular location: default

STOICHIOMETRY ID s3373 csa98
type: Stoichiometry
physical entity: APBB1-AICD
stoichiometric coefficient: 1.0

Eicosanoid s3568 sa2475 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Eicosanoid s3568 sa2475
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3195 csa105
type: Stoichiometry
physical entity: AmyloidB-ALB
stoichiometric coefficient: 1.0

ABCA1 s3163 sa203 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ABCA1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re165 255
type: Stoichiometry
physical entity: CASP6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re165 256
type: Stoichiometry
physical entity: CASP6
stoichiometric coefficient: 1.0

NPC
type: Protein

KNOWN_TRANSITION_OMITTED_LEFT__Modulation_of_gene_expression_-RIGHT__Cell_Death-_re33
type: Interaction
participant: Cell Death s119 sa77
participant: Modulation of gene expression
xref: KNOWN TRANSITION OMITTED

STATE_TRANSITION_RIGHT__APC_AXIN_GSK3B_CTNNB1-_re247
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re247 353
conversion direction: LEFT_TO_RIGHT
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APC-AXIN-GSK3B-CTNNB1
xref: STATE TRANSITION

NFKB
type: Protein
cellular location: astrocyte c2

PSEN1 s971 sa311 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSEN1
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re5 2
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re5 1
type: Stoichiometry
physical entity: AmyloidB1-40
stoichiometric coefficient: 1.0

KAT5
type: Protein
cellular location: nucleus c3

NTF3
type: Protein

STOICHIOMETRY ID s3362 csa168
type: Stoichiometry
physical entity: APOE-LPL-LIPC-Lipoprotein remnant
stoichiometric coefficient: 1.0

Generation of reactive oxygen species
type: Pathway

APOE
type: RnaRegion
cellular location: neuron c1

LBP-1-TFCP2-PCBP2
type: Complex
component: LBP 1 s2715 sa2188
component: TFCP2 s2720 sa2193
component: PCBP2 s1468 sa1125
cellular location: nucleus c3

AmyloidB1 42 s343 sa307 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 7.0

LRP8-RELN
type: Complex
component: LRP8
component: RELN
cellular location: neuron c1

STATE_TRANSITION_LEFT__IGF1R-RIGHT__IGF1R-_re826
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re826 1327
participant stoichiometry: PARTICIPANT STOICHIOMETRY re826 1328
conversion direction: LEFT_TO_RIGHT
left: IGF1R
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IGF1R
xref: STATE TRANSITION

K+
type: SmallMolecule
cellular location: microglia c4

IP3 s1770 sa1307 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 2.0

Oligomeric AmyloidB-HSD17B10
type: Complex
component: HSD17B10
component: Oligomeric AmyloidB
cellular location: inner membrane c8

MAPT s3010 sa2363 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re699 1131
type: Stoichiometry
physical entity: SFRP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re699 1132
type: Stoichiometry
physical entity: SFRP-WNT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re699 1130
type: Stoichiometry
physical entity: WNT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1289 2034
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 1.0

UQCR s192 sa286 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UQCR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1289 2036
type: Stoichiometry
physical entity: AmyloidB1 42 FPRL1 s3816 csa314
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1289 2035
type: Stoichiometry
physical entity: FPRL1
stoichiometric coefficient: 1.0

SOD s2355 sa1838 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SOD s2355 sa1838
stoichiometric coefficient: 1.0

IK s3464 sa2120 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IK
stoichiometric coefficient: 1.0

testosterone s900 sa620 STOICHIOMETRY ID
type: Stoichiometry
physical entity: testosterone
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule

DAB
type: Protein

re366 s2763 sa2230 595
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__MAPK8-RIGHT__MAPK8-_re366
control type: INHIBITION
controller: IGF1 s2763 sa2230

AmyloidB s3791 sa2703 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 2.0

CYC
type: Protein
cellular location: neuron c1

RELN
type: Protein

STATE_TRANSITION_LEFT__BCL2-RIGHT__BCL2-_re687
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re687 1108
participant stoichiometry: PARTICIPANT STOICHIOMETRY re687 1107
conversion direction: LEFT_TO_RIGHT
left: BCL2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: BCL2
xref: STATE TRANSITION

APOE s1313 sa976 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APOE s1313 sa976
stoichiometric coefficient: 1.0

SDC2
type: Protein
cellular location: default

C99 s2758 sa2225 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C99
stoichiometric coefficient: 1.0

Delta
type: Protein

PARTICIPANT STOICHIOMETRY re862 1407
type: Stoichiometry
physical entity: HMGCR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re862 1406
type: Stoichiometry
physical entity: HMGCR
stoichiometric coefficient: 1.0

NALP1 s3784 sa2692 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NALP1
stoichiometric coefficient: 1.0

HSPA5
type: DnaRegion
cellular location: endoplasmic reticulum ER c5

HETERODIMER_ASSOCIATION_LEFT__NGF-_NGFR-RIGHT__NGFR_NGF-_re379
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re379 634
participant stoichiometry: PARTICIPANT STOICHIOMETRY re379 633
participant stoichiometry: PARTICIPANT STOICHIOMETRY re379 632
conversion direction: LEFT_TO_RIGHT
left: NGF
left: NGFR
interaction type: HETERODIMER_ASSOCIATION
right: NGFR-NGF
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re549 929
type: Stoichiometry
physical entity: AGER
stoichiometric coefficient: 1.0

GRIN s1992 sa886 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GRIN s1992 sa886
stoichiometric coefficient: 2.0

glutamate-GRIN-Mg2+
type: Complex
component: GRIN
component: Mg2+
component: glutamate s1206 sa1497
cellular location: postsynaptic density c12

HETERODIMER_ASSOCIATION_LEFT__TLR4-_DAMPs-RIGHT__TLR4_DAMPs-_re1257
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1257 2000
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1257 1998
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1257 1999
conversion direction: LEFT_TO_RIGHT
left: TLR4
left: DAMPs
interaction type: HETERODIMER_ASSOCIATION
right: TLR4-DAMPs
spontaneous: true
xref: HETERODIMER ASSOCIATION

16,17S DHA Epoxide s3826 sa2735 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 16,17S-DHA Epoxide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re354 573
type: Stoichiometry
physical entity: Lanosterol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re354 572
type: Stoichiometry
physical entity: Oxydosqualene
stoichiometric coefficient: 1.0

ATG7
type: Protein

RAC1
type: Protein

CALM-Ca2+
type: Complex
component: Ca2+
component: CALM
cellular location: neuron c1

STOICHIOMETRY ID s3206 csa197
type: Stoichiometry
physical entity: ATG12-ATG10
stoichiometric coefficient: 1.0

PE s2224 sa1726 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PE
stoichiometric coefficient: 1.0

unknown NT
type: PhysicalEntity

PARTICIPANT STOICHIOMETRY re115 190
type: Stoichiometry
physical entity: LT s81 sa158
stoichiometric coefficient: 1.0

sa286_degraded
type: PhysicalEntity
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re115 191
type: Stoichiometry
physical entity: LT s398 sa167
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3861 csa317
type: Stoichiometry
physical entity: A2MLRP
stoichiometric coefficient: 1.0

cognitive and behavioral abnormalities
type: Pathway

TLR9-AmyloidB
type: Complex
component: AmyloidB
component: TLR9
cellular location: microglia c4

HETERODIMER_ASSOCIATION_LEFT__TLR4-_DAMPs-RIGHT__TLR4_DAMPs-_re1242
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1242 1969
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1242 1968
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1242 1970
conversion direction: LEFT_TO_RIGHT
left: DAMPs
left: TLR4
interaction type: HETERODIMER_ASSOCIATION
right: TLR4-DAMPs
spontaneous: true
xref: HETERODIMER ASSOCIATION

re61 s2369 sa1856 105
type: Control
xref: INHIBITION
controlled: STATE TRANSITION LEFT PI 4,5 P2-RIGHT PIP3- re61
control type: INHIBITION
controller: PTEN

HETERODIMER_ASSOCIATION_LEFT__CAPN2-_mutant_PSEN-RIGHT__CAPN2_mutant_PSEN-_re1068
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1068 1679
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1068 1681
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1068 1680
conversion direction: LEFT_TO_RIGHT
left: mutant PSEN
left: CAPN2
interaction type: HETERODIMER_ASSOCIATION
right: CAPN2-mutant PSEN
spontaneous: true
xref: HETERODIMER ASSOCIATION

CCNE s3449 sa148 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CCNE
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__NFKB_responsive_genes-RIGHT__NF_KB_responsive-_re717
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: NF-KB responsive
controller: NFKB responsive genes

PARTICIPANT STOICHIOMETRY re564 954
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re564 953
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

LAG3 s41 sa2031 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LAG3
stoichiometric coefficient: 2.0

TLRs-PAMPs
type: Complex
component: TLRs s3741 sa2656
component: PAMPs
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re549 930
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

Insulin receptor
type: Protein
cellular location: neuron c1

AICD s12 sa40 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

L Cys s1319 sa982 STOICHIOMETRY ID
type: Stoichiometry
physical entity: L-Cys
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Oligomeric_AmyloidB-RIGHT__Oligomeric_AmyloidB-_re1033
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1033 1640
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1033 1641
conversion direction: LEFT_TO_RIGHT
left: Oligomeric AmyloidB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Oligomeric AmyloidB
xref: TRANSPORT

HETERODIMER_ASSOCIATION_LEFT__lipoxin_A4-_FPRL1-RIGHT__FPRL1_lipoxinA4-_re1211
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1211 1913
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1211 1912
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1211 1911
conversion direction: LEFT_TO_RIGHT
left: lipoxin A4
left: FPRL1
interaction type: HETERODIMER_ASSOCIATION
right: FPRL1 lipoxinA4 s3677 csa293
spontaneous: true
xref: HETERODIMER ASSOCIATION

NCOR2 s2570 sa2024 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NCOR2
stoichiometric coefficient: 3.0

TRANSPORT_LEFT__L_Cysteinesulfinate-RIGHT__L_Cysteinesulfinate-_re462
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re462 766
participant stoichiometry: PARTICIPANT STOICHIOMETRY re462 767
conversion direction: LEFT_TO_RIGHT
left: L Cysteinesulfinate s1321 sa984
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: L-Cysteinesulfinate
xref: TRANSPORT

CREB
type: Protein
cellular location: nucleus c3

Lipoprotein remnant
type: SmallMolecule
cellular location: sinusoid c28

VCAM1 s1641 sa1255 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VCAM1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__TREM2-_unknown_protein-RIGHT__TREM2_unknown_protein-_re1253
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1253 1989
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1253 1990
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1253 1991
conversion direction: LEFT_TO_RIGHT
left: unknown protein
left: TREM2 s3758 sa2669
interaction type: HETERODIMER_ASSOCIATION
right: TREM2 unknown protein s3759 csa307
spontaneous: true
xref: HETERODIMER ASSOCIATION

BDNF s2295 sa1788 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BDNF s2295 sa1788
stoichiometric coefficient: 1.0

re635 s2755 sa19 1067
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__BCL2L1-RIGHT__BCL2L1-_re635
control type: INHIBITION
controller: BAD

PARTICIPANT STOICHIOMETRY re1241 1965
type: Stoichiometry
physical entity: DAMPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1241 1966
type: Stoichiometry
physical entity: TLR2
stoichiometric coefficient: 1.0

PPP2CA s1756 sa1293 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPP2CA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1241 1967
type: Stoichiometry
physical entity: TLR2-DAMPs
stoichiometric coefficient: 1.0

PLCB
type: Protein
cellular location: neuron c1

ADP
type: SmallMolecule
cellular location: neuron c1

nucleus c3
type: CellularLocationVocabulary
comment: _nucleus

NH3
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re976 1603
type: Stoichiometry
physical entity: APP MAPK8IP1 s3291 csa257
stoichiometric coefficient: 1.0

NGFR s1163 sa856 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re976 1601
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re976 1602
type: Stoichiometry
physical entity: MAPK8IP1
stoichiometric coefficient: 1.0

GRIN
type: Protein

CD3E
type: Protein
feature: CD3E CD3E s2464 sa2371 rs1

CASP9
type: Protein
feature: CASP9 CASP9 s614 sa408 Active

cGMP
type: SmallMolecule
cellular location: postsynaptic density c12

UNKNOWN_TRANSITION_LEFT__50kDa_fragment-RIGHT__Neurofibrillary_tangles_NFTs_-_re1060
type: Control
xref: UNKNOWN TRANSITION
controlled: Neurofibrillary tangles(NFTs)
controller: 50kDa fragment

CCNA
type: Protein
cellular location: neuron c1

RIPK2 s3728 sa2642 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RIPK2
stoichiometric coefficient: 1.0

TNFRSF1A
type: Protein
feature: TNFRSF1A TNFRSF1A s2774 sa2238 Active

IRS2 s3882 sa2800 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IRS2
stoichiometric coefficient: 1.0

ADAM
type: Protein
cellular location: neuron c1

H PLUS s188 sa288 STOICHIOMETRY ID
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 1.0

EDN1
type: Protein
cellular location: blood brain barrier BBB c22

STATE_TRANSITION_LEFT__GTPase_GDI-RIGHT__GDI-_GTPase-_re868
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re868 1418
participant stoichiometry: PARTICIPANT STOICHIOMETRY re868 1419
participant stoichiometry: PARTICIPANT STOICHIOMETRY re868 1417
conversion direction: LEFT_TO_RIGHT
left: GTPase-GDI
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GDI
right: GTPase s2864 sa2269
xref: STATE TRANSITION

PRIM1
type: Protein

MARCO
type: Protein
cellular location: astrocyte c2

re830 s2790 sa1858 1336
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__PTEN-RIGHT__PTEN-_re830
control type: INHIBITION
controller: IFI44 s2790 sa1858

PLAT
type: Protein
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__COX2-RIGHT__Inflammatory_signaling-_re1302
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammatory signaling
controller: COX2

NEDD8 s779 sa506 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NEDD8
stoichiometric coefficient: 1.0

AmyloidB1-42
type: Protein
cellular location: microglia c4

STATE_TRANSITION_LEFT__PPP3-RIGHT__PPP3-_re846
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re846 1377
participant stoichiometry: PARTICIPANT STOICHIOMETRY re846 1376
conversion direction: LEFT_TO_RIGHT
left: PPP3
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PPP3
xref: STATE TRANSITION

STOICHIOMETRY ID s3257 csa158
type: Stoichiometry
physical entity: DAG-IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re636 1072
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re636 1071
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NTRK1_NGF-RIGHT__ACh_production-_re1125
type: Control
xref: STATE TRANSITION
controlled: ACh production
controller: NTRK1 NGF s3176 csa102

AA production
type: Pathway

CDKN2A s3453 sa352 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDKN2A
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re891 1465
type: Stoichiometry
physical entity: RHEB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re891 1466
type: Stoichiometry
physical entity: RHEB
stoichiometric coefficient: 1.0

re258 s910 sa633 375
type: Control
xref: UNKNOWN INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__CTNNB1-_APC_GSK3B_AXIN-_re258
control type: INHIBITION
controller: PIK3

survival
type: Pathway

Cys-S-R
type: SmallMolecule
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__Mitochondrial_dysfunction-RIGHT__Cell_Death-_re36
type: Interaction
participant: Mitochondrial dysfunction s462 sa81
participant: Cell Death s119 sa77
xref: KNOWN TRANSITION OMITTED

DMRT1 s2628 sa2091 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DMRT1
stoichiometric coefficient: 1.0

ceramide s2346 sa1825 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ceramide
stoichiometric coefficient: 1.0

KAT5
type: Protein

HETERODIMER_ASSOCIATION_LEFT__APBB1-_AICD-RIGHT__APBB1_AICD-_re1038
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1038 1650
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1038 1649
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1038 1648
conversion direction: LEFT_TO_RIGHT
left: APBB1
left: AICD
interaction type: HETERODIMER_ASSOCIATION
right: APBB1-AICD
spontaneous: true
xref: HETERODIMER ASSOCIATION

TLR2 s3594 sa2499 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLR2
stoichiometric coefficient: 4.0

ATRA s721 sa303 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATRA s721 sa303
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3333 csa31
type: Stoichiometry
physical entity: APOE-cholesterol
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CAMK2-RIGHT__CAMK2-_re705
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re705 1144
participant stoichiometry: PARTICIPANT STOICHIOMETRY re705 1143
conversion direction: LEFT_TO_RIGHT
left: CAMK2 s2053 sa1569
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CAMK2 s2053 sa1570
xref: STATE TRANSITION

UBA1 s933 sa651 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UBA1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re422 707
type: Stoichiometry
physical entity: AmyloidB1 42 s1280 sa944
stoichiometric coefficient: 5.0

s3080 s3080 sa2429 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s3080
stoichiometric coefficient: 1.0

phosphatase s2151 sa1662 STOICHIOMETRY ID
type: Stoichiometry
physical entity: phosphatase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re422 706
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_UBA1-RIGHT__UBA1-_AMP-_re292
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re292 453
participant stoichiometry: PARTICIPANT STOICHIOMETRY re292 452
participant stoichiometry: PARTICIPANT STOICHIOMETRY re292 454
participant stoichiometry: PARTICIPANT STOICHIOMETRY re292 451
conversion direction: LEFT_TO_RIGHT
left: ATP s890 sa613
left: UBA1 s898 sa615
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: AMP
right: UBA1
xref: STATE TRANSITION

LRP1-APOE-SDC2-Lipoprotein remnant
type: Complex
component: Lipoprotein remnant
component: SDC2
component: LRP1
component: APOE s470 sa315
cellular location: sinusoid c28

STOICHIOMETRY ID s3348 csa207
type: Stoichiometry
physical entity: TNFRSF1A-TNF
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAPK8-RIGHT__MAPK8-_re366
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re366 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY re366 603
conversion direction: LEFT_TO_RIGHT
left: MAPK8
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPK8
xref: STATE TRANSITION

STOICHIOMETRY ID s3634 csa291
type: Stoichiometry
physical entity: NALP-AmyloidB
stoichiometric coefficient: 1.0

tissue injured
type: Pathway

GSSG s2699 sa2176 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSSG
stoichiometric coefficient: 1.0

HMGB1
type: Protein
feature: HMGB1 HMGB1 s3470 sa2450 Active
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__TNF-RIGHT__neurotoxin-_re1107
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: neurotoxin s3062 sa2418
controller: TNF s2777 sa2240

HETERODIMER_ASSOCIATION_LEFT__APBB1_AICD-_LBP_1_TFCP2_PCBP2-RIGHT__APBB1_AICD_LBP_1_TFCP2_PCBP2-_re974
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re974 1595
participant stoichiometry: PARTICIPANT STOICHIOMETRY re974 1596
participant stoichiometry: PARTICIPANT STOICHIOMETRY re974 1597
conversion direction: LEFT_TO_RIGHT
left: LBP-1-TFCP2-PCBP2
left: APBB1-AICD
interaction type: HETERODIMER_ASSOCIATION
right: APBB1 AICD LBP 1 TFCP2 PCBP2 s3375 csa255
spontaneous: true
xref: HETERODIMER ASSOCIATION

AB channel s3782 sa2688 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AB channel s3782 sa2688
stoichiometric coefficient: 1.0

oxidase s3606 sa2509 STOICHIOMETRY ID
type: Stoichiometry
physical entity: oxidase
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__thiosulfate-_2GSH-RIGHT__GSSG_PLUS_HS_-_sulfite-_re478
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re478 777
participant stoichiometry: PARTICIPANT STOICHIOMETRY re478 774
participant stoichiometry: PARTICIPANT STOICHIOMETRY re478 776
participant stoichiometry: PARTICIPANT STOICHIOMETRY re478 775
conversion direction: LEFT_TO_RIGHT
left: 2GSH
left: thiosulfate
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sulfite s1346 sa1010
right: GSSG+HS-
xref: STATE TRANSITION

Met sulfide radical cation s1126 sa827 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Met sulfide radical cation
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3224 csa125
type: Stoichiometry
physical entity: metal ligand Cu s3224 csa125
stoichiometric coefficient: 1.0

SRA1 s3705 sa2617 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRA1
stoichiometric coefficient: 1.0

ACh
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re393 651
type: Stoichiometry
physical entity: GABA-GABR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re393 650
type: Stoichiometry
physical entity: GABR s3092 sa783
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re140 215
type: Stoichiometry
physical entity: cholesterol s3164 sa188
stoichiometric coefficient: 1.0

WNT7A s2056 sa1771 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT7A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re393 649
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

ATG13-ATG11-ULK1-ATG17
type: Complex
component: ATG13 s2168 sa1678
component: ATG17
component: ATG11 s2175 sa1681
component: ULK1
cellular location: neuron c1

Kv3.4 s3790 sa2702 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Kv3.4 s3790 sa2702
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1257 2000
type: Stoichiometry
physical entity: TLR4-DAMPs
stoichiometric coefficient: 1.0

CLU s1555 sa1198 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CLU
stoichiometric coefficient: 1.0

Insulin receptor
type: Protein
feature: Insulin receptor Insulin receptor s3888 sa2808 Active

PARTICIPANT STOICHIOMETRY re140 216
type: Stoichiometry
physical entity: cholesterol s87 sa190
stoichiometric coefficient: 1.0

GRIA
type: Protein
cellular location: neuron c1

TNFRSF1A s2237 sa67 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFRSF1A s2237 sa67
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re863 1410
type: Stoichiometry
physical entity: FNTA
stoichiometric coefficient: 1.0

OXCT1 s678 sa272 STOICHIOMETRY ID
type: Stoichiometry
physical entity: OXCT1
stoichiometric coefficient: 1.0

TH s1531 sa1176 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TH
stoichiometric coefficient: 1.0

LO
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re259 379
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

Caspase cascade
type: Pathway

PARTICIPANT STOICHIOMETRY re259 378
type: Stoichiometry
physical entity: APC-AXIN-GSK3B-CTNNB1
stoichiometric coefficient: 1.0

IKBK s2081 sa1452 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IKBK
stoichiometric coefficient: 1.0

PTGS s3027 sa2378 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PTGS s3027 sa2378
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__glucose-RIGHT__glucose-_re1332
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1332 2138
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1332 2137
conversion direction: LEFT_TO_RIGHT
left: glucose
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: glucose
xref: STATE TRANSITION

APOE-cholesterol
type: Complex
component: cholesterol
component: APOE s470 sa315
cellular location: neuron c1

RTK s2078 sa1598 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RTK
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__ER_stress-RIGHT__mutant_PSEN-_re1067
type: Interaction
participant: mutant PSEN
participant: ER stress s191 sa119
xref: KNOWN TRANSITION OMITTED

PAMPs
type: Protein

ADRBK1 s2149 sa1660 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADRBK1 s2149 sa1660
stoichiometric coefficient: 1.0

FTH-PCBP2-40S-60S
type: Complex
component: FTH
component: 60S s2832 sa1150
component: 40S s1498 sa1149
component: PCBP2 s1468 sa1125
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re863 1409
type: Stoichiometry
physical entity: FNTA
stoichiometric coefficient: 1.0

HMGCS s2481 sa1943 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HMGCS
stoichiometric coefficient: 1.0

RARE target genes
type: DnaRegion
cellular location: nucleus c3

TLR4
type: Protein
cellular location: neuron c1

20S
type: Protein

CASP2 s1761 sa2327 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAPK12-RIGHT__MAPK12-_re604
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re604 1027
participant stoichiometry: PARTICIPANT STOICHIOMETRY re604 1026
conversion direction: LEFT_TO_RIGHT
left: MAPK12 s1801 sa1339
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPK12
xref: STATE TRANSITION

GlcNAc1P s3903 sa2821 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GlcNAc1P
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__NFKB_responsive_genes-RIGHT__NFKB_responsive_genes-_re312
type: TemplateReaction
participant: NFKB responsive genes
product: NFKB responsive genes
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

KNOWN_TRANSITION_OMITTED_LEFT__Unknown_transportation-RIGHT__AmyloidB_A2M-_re1032
type: Interaction
participant: Unknown transportation
participant: AmyloidB A2M s3306 csa267
xref: KNOWN TRANSITION OMITTED

NFKBI s3473 sa1470 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKBI
stoichiometric coefficient: 1.0

CDKN1A s74 sa144 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDKN1A s74 sa144
stoichiometric coefficient: 1.0

chylomicrons
type: SmallMolecule
cellular location: sinusoid c28

CN s3849 sa2761 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CN
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__ceramide-RIGHT__Apoptosis-_re1153
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Apoptosis
controller: ceramide

PARTICIPANT STOICHIOMETRY re1066 1677
type: Stoichiometry
physical entity: mutant PSEN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1066 1678
type: Stoichiometry
physical entity: CTNNB1-GSK3B-PRKA-PSEN
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3186 csa41
type: Stoichiometry
physical entity: NCOR1-RXR-RARA
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3202 csa177
type: Stoichiometry
physical entity: glutamate-GRIN-Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 28
type: Stoichiometry
physical entity: APPBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 29
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAP2K1-RIGHT__MAP2K1-_re744
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re744 1189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re744 1188
conversion direction: LEFT_TO_RIGHT
left: MAP2K1 s2136 sa1649
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAP2K1 s2136 sa1650
xref: STATE TRANSITION

TRANSPORT_LEFT__PG-RIGHT__PG-_re114
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re114 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY re114 189
conversion direction: LEFT_TO_RIGHT
left: PG s78 sa157
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: PG
xref: TRANSPORT

s2025 s2025 sa1545 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s2025 s2025 sa1545
stoichiometric coefficient: 1.0

5'GMP s1257 sa924 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 5'GMP
stoichiometric coefficient: 1.0

sAPPA s2410 sa1890 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sAPPA
stoichiometric coefficient: 1.0

glucocorticoid
type: SmallMolecule
cellular location: nucleus c3

re1331 s2927 sa2301 2131
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__FOXO1-RIGHT__FOXO1-_re1331
control type: INHIBITION
controller: AKT1

PARTICIPANT STOICHIOMETRY re1082 1713
type: Stoichiometry
physical entity: LRP1-APOE-Lipoprotein remnant
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1082 1712
type: Stoichiometry
physical entity: LRP1
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3188 csa194
type: Stoichiometry
physical entity: ATG13-ATG11-ULK1-ATG17
stoichiometric coefficient: 1.0

NO
type: SmallMolecule
cellular location: postsynaptic density c12

PARTICIPANT STOICHIOMETRY re20 30
type: Stoichiometry
physical entity: APPBP1 APP s3324 csa17
stoichiometric coefficient: 1.0

WNT5A s2060 sa1769 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT5A s2060 sa1769
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1082 1711
type: Stoichiometry
physical entity: APOE Lipoprotein remnant s3361 csa166
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1266 2002
type: Stoichiometry
physical entity: some ions
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1162 1816
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1266 2001
type: Stoichiometry
physical entity: some ions
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re308 467
type: Stoichiometry
physical entity: APBB1-AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1162 1814
type: Stoichiometry
physical entity: TLR4 AmyloidB s3590 csa284
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1162 1815
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

neural precursor cell c31
type: CellularLocationVocabulary
comment: _neural_precursor_cell

PARTICIPANT STOICHIOMETRY re308 466
type: Stoichiometry
physical entity: APBB1-AICD
stoichiometric coefficient: 1.0

GOT2 s1355 sa1021 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GOT2 s1355 sa1021
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re200 281
type: Stoichiometry
physical entity: Glyceraldehyde-P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re200 280
type: Stoichiometry
physical entity: Glucose s635 sa239
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re200 282
type: Stoichiometry
physical entity: TIMP1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re1312
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1312 2077
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1312 2078
conversion direction: LEFT_TO_RIGHT
left: Ca2+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Ca2+
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re347 560
type: Stoichiometry
physical entity: Farnesyl PP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re547 926
type: Stoichiometry
physical entity: s1577
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re547 925
type: Stoichiometry
physical entity: sLRP-AmyloidB
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NADH-RIGHT__TCA_cycle-_re1000
type: Control
xref: STATE TRANSITION
controlled: TCA cycle
controller: NADH

sphingomyelin s3086 sa1829 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sphingomyelin
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__APP-_SHC1-RIGHT__APP_SHC1-_re978
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re978 1608
participant stoichiometry: PARTICIPANT STOICHIOMETRY re978 1607
participant stoichiometry: PARTICIPANT STOICHIOMETRY re978 1609
conversion direction: LEFT_TO_RIGHT
left: APP
left: SHC1
interaction type: HETERODIMER_ASSOCIATION
right: APP-SHC1
spontaneous: true
xref: HETERODIMER ASSOCIATION

ABCA1 s3163 sa201 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ABCA1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__phosphatase-RIGHT__phosphatase-_re748
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re748 1201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re748 1202
conversion direction: LEFT_TO_RIGHT
left: phosphatase
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: phosphatase
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__peroxynitrite__ONOO__-RIGHT__Mitochondrial_dysfunction-_re51
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Mitochondrial dysfunction s462 sa81
controller: peroxynitrite (ONOO-)

24-OH-Chol
type: SmallMolecule

TTR s2510 sa842 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TTR
stoichiometric coefficient: 1.0

C5B
type: Protein

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re1094
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1094 1730
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1094 1731
conversion direction: LEFT_TO_RIGHT
left: Ca2+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Ca2 PLUS s3054 sa2401
xref: TRANSPORT

STATE_TRANSITION_LEFT__ceramide-RIGHT__sphingomyelin-_re834
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re834 1346
participant stoichiometry: PARTICIPANT STOICHIOMETRY re834 1345
conversion direction: LEFT_TO_RIGHT
left: ceramide
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sphingomyelin
xref: STATE TRANSITION

APOE s123 sa199 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

UDP-GlcNAc
type: SmallMolecule
cellular location: neuron c1

NR1H-24-OH-Chol
type: Complex
component: NR1H
component: 24-OH-Chol
cellular location: nucleus c3

glucose
type: SmallMolecule
cellular location: default

APPBP1
type: Protein

unknown repressor s2272 sa1767 STOICHIOMETRY ID
type: Stoichiometry
physical entity: unknown repressor s2272 sa1767
stoichiometric coefficient: 1.0

RTK
type: Protein
feature: RTK RTK s2078 sa1598 Active
cellular location: neuron c1

thiosulfate:thiol sulfurtransferase
type: Protein
cellular location: mitochondria c7

MAP2K7
type: Protein
feature: MAP2K7 MAP2K7 s1909 sa1431 rs1
feature: MAP2K7 MAP2K7 s1909 sa1431 Active
cellular location: MAPK cascade c6

STATE_TRANSITION_LEFT__NFKB-RIGHT__NFKB-_re1226
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1226 1939
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1226 1940
conversion direction: LEFT_TO_RIGHT
left: NFKB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NFKB
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re347 559
type: Stoichiometry
physical entity: GPP
stoichiometric coefficient: 1.0

AmyloidB-TTR
type: Complex
component: TTR
component: AmyloidB
cellular location: CSF c16

PARTICIPANT STOICHIOMETRY re1288 2032
type: Stoichiometry
physical entity: humanin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1288 2033
type: Stoichiometry
physical entity: humanin FPRL1 s3815 csa313
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1288 2031
type: Stoichiometry
physical entity: FPRL1
stoichiometric coefficient: 1.0

NEDD8
type: Protein
feature: NEDD8 NEDD8 s779 sa507 Active
cellular location: neuron c1

STATE_TRANSITION_LEFT__EIF4EBP1-RIGHT__EIF4EBP1-_re903
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re903 1494
participant stoichiometry: PARTICIPANT STOICHIOMETRY re903 1495
conversion direction: LEFT_TO_RIGHT
left: EIF4EBP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: EIF4EBP1
xref: STATE TRANSITION

ROS s1585 sa1220 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

AmyloidB s1595 sa1232 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 5.0

CYP46A1
type: Protein
feature: CYP46A1 CYP46A1 s520 sa196 Active
cellular location: neuron c1

GPP
type: SmallMolecule
cellular location: neuron c1

CCL2 s3765 sa2675 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CCL2 s3765 sa2675
stoichiometric coefficient: 1.0

geranyl geraniol s539 sa205 STOICHIOMETRY ID
type: Stoichiometry
physical entity: geranyl geraniol s539 sa205
stoichiometric coefficient: 1.0

NEDD8
type: Protein
cellular location: neuron c1

C3B
type: Protein
feature: C3B C3B s1283 sa943 Active

sAPPA s2640 sa2099 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sAPPA s2640 sa2099
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__NFAT-RIGHT__NFAT-_re848
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re848 1381
participant stoichiometry: PARTICIPANT STOICHIOMETRY re848 1382
conversion direction: LEFT_TO_RIGHT
left: NFAT s2437 sa1912
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: NFAT
xref: TRANSPORT

ATG13 s2168 sa1678 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG13 s2168 sa1678
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__APAF1-RIGHT__APAF1-_re171
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re171 265
participant stoichiometry: PARTICIPANT STOICHIOMETRY re171 264
conversion direction: LEFT_TO_RIGHT
left: APAF1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APAF1
xref: STATE TRANSITION

C3B s3489 sa946 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C3B s3489 sa946
stoichiometric coefficient: 3.0

HSD17B10
type: Protein
feature: HSD17B10 HSD17B10 s122 sa2323 Active
cellular location: inner membrane c8

Ca2+
type: SmallMolecule
cellular location: default

STOICHIOMETRY ID s3271 csa185
type: Stoichiometry
physical entity: VLDLR-APOE
stoichiometric coefficient: 1.0

LEF1
type: Protein

re219 s907 sa630 308
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__UQCR-RIGHT__UQCR-_re219
control type: ACTIVATION
controller: estrogen

RAF1
type: Protein
feature: RAF1 RAF1 s1419 sa1081 Active
cellular location: neuron c1

GAPDH s2817 sa2256 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GAPDH s2817 sa2256
stoichiometric coefficient: 1.0

AmyloidB fibril s2665 sa2153 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB fibril s2665 sa2153
stoichiometric coefficient: 1.0

sLRP
type: Protein
cellular location: Blood c15

TRANSPORT_LEFT__acetylcholine-RIGHT__acetyl_CoA-_re217
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re217 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY re217 302
conversion direction: LEFT_TO_RIGHT
left: acetylcholine
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: acetyl-CoA
xref: TRANSPORT

STOICHIOMETRY ID s3677 csa293
type: Stoichiometry
physical entity: FPRL1 lipoxinA4 s3677 csa293
stoichiometric coefficient: 1.0

s1594
type: PhysicalEntity
cellular location: Brain c26

sphingomyelin
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1063 1675
type: Stoichiometry
physical entity: ZAP70
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1063 1674
type: Stoichiometry
physical entity: ZAP70
stoichiometric coefficient: 1.0

P2X7 s3608 sa2511 STOICHIOMETRY ID
type: Stoichiometry
physical entity: P2X7 s3608 sa2511
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re590 980
type: Stoichiometry
physical entity: DAG-IP3
stoichiometric coefficient: 1.0

phospholipase D s3683 sa2597 STOICHIOMETRY ID
type: Stoichiometry
physical entity: phospholipase D s3683 sa2597
stoichiometric coefficient: 1.0

ACTA1 s1318 sa981 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACTA1
stoichiometric coefficient: 1.0

IL6 s1620 sa1244 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6 s1620 sa1244
stoichiometric coefficient: 1.0

RHEB
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__CACNA1-RIGHT__CACNA1-_re955
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re955 1566
participant stoichiometry: PARTICIPANT STOICHIOMETRY re955 1567
conversion direction: LEFT_TO_RIGHT
left: CACNA1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CACNA1
xref: STATE TRANSITION

biological damage
type: Pathway

PARTICIPANT STOICHIOMETRY re590 979
type: Stoichiometry
physical entity: PI(4,5)P2
stoichiometric coefficient: 1.0

SFRP s2029 sa1549 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SFRP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re217 303
type: Stoichiometry
physical entity: acetyl-CoA
stoichiometric coefficient: 1.0

GRIN s1989 sa880 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GRIN
stoichiometric coefficient: 4.0

TNFRSF1A-TNF
type: Complex
component: TNF
component: TNFRSF1A
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re217 302
type: Stoichiometry
physical entity: acetylcholine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Trp-RIGHT__5_HT-_re533
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re533 892
participant stoichiometry: PARTICIPANT STOICHIOMETRY re533 893
conversion direction: LEFT_TO_RIGHT
left: Trp s1529 sa1174
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: 5-HT
xref: STATE TRANSITION

PPARG
type: Protein
cellular location: nucleus c3

STOICHIOMETRY ID s3806 csa312
type: Stoichiometry
physical entity: RAGE-S100/calgranulin
stoichiometric coefficient: 1.0

RHOA-GGPP
type: Complex
component: GGPP
component: RHOA
cellular location: neuron c1

pyruvate
type: SmallMolecule
cellular location: mitochondria c7

UBA3
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__LIN7-RIGHT__LIN7-_re984
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re984 1623
participant stoichiometry: PARTICIPANT STOICHIOMETRY re984 1624
conversion direction: LEFT_TO_RIGHT
left: LIN7
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: LIN7
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__K_PLUS_-RIGHT__complement_system-_re1271
type: Control
xref: STATE TRANSITION
controlled: complement system
controller: K+

NGF s1168 sa855 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NGF s1168 sa855
stoichiometric coefficient: 4.0

FADD s2810 sa2248 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1335 2146
type: Stoichiometry
physical entity: Fru6P
stoichiometric coefficient: 1.0

MAP2K4
type: Protein
cellular location: MAPK cascade c6

PCSK1 s2607 sa2071 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PCSK1 s2607 sa2071
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1335 2148
type: Stoichiometry
physical entity: GlcNH26P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1335 2147
type: Stoichiometry
physical entity: glutamine s3920 sa2837
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1335 2149
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

PRNP s507 sa185 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRNP s507 sa185
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1267 2004
type: Stoichiometry
physical entity: NALP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re315 485
type: Stoichiometry
physical entity: proNGF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re315 486
type: Stoichiometry
physical entity: NGF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1267 2003
type: Stoichiometry
physical entity: DAMPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re540 911
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAPT_-RIGHT__MAPT-_re597
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re597 1004
participant stoichiometry: PARTICIPANT STOICHIOMETRY re597 1003
conversion direction: LEFT_TO_RIGHT
left: MAPT s3448 sa85
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPT
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re540 912
type: Stoichiometry
physical entity: LRP1-AmyloidB
stoichiometric coefficient: 1.0

CYP46A1 s520 sa196 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CYP46A1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re540 910
type: Stoichiometry
physical entity: LRP1 s3498 sa1195
stoichiometric coefficient: 1.0

synaptic plasticity
type: Pathway

HETERODIMER_ASSOCIATION_LEFT__CAV1-RIGHT__AGER_AmyloidB_CAV1-_re560
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re560 944
participant stoichiometry: PARTICIPANT STOICHIOMETRY re560 945
conversion direction: LEFT_TO_RIGHT
left: CAV1
interaction type: HETERODIMER_ASSOCIATION
right: AGER AmyloidB CAV1 s3245 csa150
spontaneous: true
xref: HETERODIMER ASSOCIATION

Oligomeric AmyloidB
type: Protein
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__BCL2-RIGHT__survival-_re688
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: survival
controller: BCL2

STATE_TRANSITION_LEFT__UBA1_UB-_UBE2-RIGHT__UBA1-_UBE2_UB-_re272
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re272 402
participant stoichiometry: PARTICIPANT STOICHIOMETRY re272 401
participant stoichiometry: PARTICIPANT STOICHIOMETRY re272 403
participant stoichiometry: PARTICIPANT STOICHIOMETRY re272 404
conversion direction: LEFT_TO_RIGHT
left: UBA1-UB
left: UBE2 s894 sa618
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: UBE2-UB
right: UBA1 s898 sa615
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__FOXO1-RIGHT__FOXO1-_re1331
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1331 2132
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1331 2133
conversion direction: LEFT_TO_RIGHT
left: FOXO1 s3895 sa2813
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FOXO1 s3895 sa2813
xref: STATE TRANSITION

RHEB
type: Protein
feature: RHEB RHEB s3459 sa2054 Active
cellular location: neuron c1

unknown receptor-sAPPA
type: Complex
component: sAPPA s2640 sa2099
component: Unknown receptor s2639 sa2098
cellular location: neuron c1

ATP1 s3483 sa2130 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP1 s3483 sa2130
stoichiometric coefficient: 1.0

NALP-AmyloidB
type: Complex
component: NALP
component: AmyloidB
cellular location: microglia c4

NO s1262 sa919 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re881 1439
type: Stoichiometry
physical entity: INPP5K-CSHL1-HDAC-NCOR2
stoichiometric coefficient: 1.0

BDNF-NTRK2
type: Complex
component: BDNF
component: NTRK2
cellular location: neuron c1

MAPK1/3
type: Protein
feature: MAPK1 3 MAPK1 3 s197 sa126 rs1
feature: MAPK1 3 MAPK1 3 s197 sa126 Active
cellular location: MAPK cascade c6

STATE_TRANSITION_LEFT__EIF2AK3-RIGHT__EIF2AK3-_re64
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 110
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 109
conversion direction: LEFT_TO_RIGHT
left: EIF2AK3 s132 sa112
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: EIF2AK3
xref: STATE TRANSITION

ATG12-ATG7
type: Complex
component: ATG12
component: ATG7
cellular location: neuron c1

CACNA1
type: Protein
feature: CACNA1 CACNA1 s60 sa2161 Active
cellular location: neuron c1

CALM s1225 sa902 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CALM
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re705 1144
type: Stoichiometry
physical entity: CAMK2 s2053 sa1570
stoichiometric coefficient: 1.0

RAF1
type: Protein
cellular location: neuron c1

pyruvate s1354 sa1020 STOICHIOMETRY ID
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

re199 s904 sa627 275
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PFK-RIGHT__PFK-_re199
control type: ACTIVATION
controller: estrogen

NTF4
type: Protein
cellular location: default

TPH s1530 sa1175 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re705 1143
type: Stoichiometry
physical entity: CAMK2 s2053 sa1569
stoichiometric coefficient: 1.0

VPS29
type: Protein

GLUT3
type: Protein
feature: GLUT3 GLUT3 s3906 sa2824 Active
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB_fibril_formation-RIGHT__Senile_plaque-_re123
type: Interaction
participant: AmyloidB fibril formation s407 sa169
participant: Senile plaque
xref: KNOWN TRANSITION OMITTED

STOICHIOMETRY ID s3710 csa299
type: Stoichiometry
physical entity: TLR2-DAMPs
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAP2K6-RIGHT__MAP2K6-_re601
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re601 1014
participant stoichiometry: PARTICIPANT STOICHIOMETRY re601 1015
conversion direction: LEFT_TO_RIGHT
left: MAP2K6
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAP2K6
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re881 1441
type: Stoichiometry
physical entity: NICD-INPP5K-CSHL1-HAT1-HDAC-NCOR2
stoichiometric coefficient: 1.0

UBE2M
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re881 1440
type: Stoichiometry
physical entity: NICD-HAT1
stoichiometric coefficient: 1.0

NADPH s1044 sa751 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re515 851
type: Stoichiometry
physical entity: 40S
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re515 853
type: Stoichiometry
physical entity: FYH PCBP1 PCBP2 s3236 csa143
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re515 852
type: Stoichiometry
physical entity: 60S
stoichiometric coefficient: 1.0

AMPAR
type: Protein
feature: AMPAR AMPAR s3850 sa2769 Active
cellular location: neuron c1

GluR s3048 sa2395 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GluR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re515 855
type: Stoichiometry
physical entity: FTH-PCBP2-40S-60S
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re515 854
type: Stoichiometry
physical entity: PCBP1
stoichiometric coefficient: 1.0

phosphatase
type: Protein
cellular location: neuron c1

CHRNA
type: Protein
feature: CHRNA CHRNA s2007 sa1515 Active
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__GDI-_GTPase-RIGHT__GTPase_GDI-_re870
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re870 1427
participant stoichiometry: PARTICIPANT STOICHIOMETRY re870 1426
participant stoichiometry: PARTICIPANT STOICHIOMETRY re870 1428
conversion direction: LEFT_TO_RIGHT
left: GDI
left: GTPase
interaction type: HETERODIMER_ASSOCIATION
right: GTPase-GDI
spontaneous: true
xref: HETERODIMER ASSOCIATION

BAD s2755 sa19 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 2.0

FAS-CASP2
type: Complex
component: CASP2
component: FAS
cellular location: neuron c1

create AB channel
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__S-RIGHT__G2-_re82
type: Interaction
participant: S
participant: G2
xref: KNOWN TRANSITION OMITTED

TST
type: Protein
cellular location: mitochondria c7

PARTICIPANT STOICHIOMETRY re839 1359
type: Stoichiometry
physical entity: RAC1
stoichiometric coefficient: 1.0

LDLR s86 sa178 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LDLR
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB1_42-_Microglia_Activation-RIGHT__Senile_plaque-_re105
type: Interaction
participant: Microglia Activation
participant: AmyloidB1 42 s1280 sa944
participant: Senile plaque
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__PSMD9-RIGHT__PSMD9-_re900
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re900 1485
participant stoichiometry: PARTICIPANT STOICHIOMETRY re900 1484
conversion direction: LEFT_TO_RIGHT
left: PSMD9
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PSMD9
xref: STATE TRANSITION

protein phosphorylation
type: Pathway

PARTICIPANT STOICHIOMETRY re361 583
type: Stoichiometry
physical entity: Met
stoichiometric coefficient: 1.0

MAPT s3448 sa85 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPT s3448 sa85
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re361 584
type: Stoichiometry
physical entity: Met SO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1252 1987
type: Stoichiometry
physical entity: TLR9
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1252 1986
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

BACE
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re1252 1988
type: Stoichiometry
physical entity: TLR9-AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re839 1360
type: Stoichiometry
physical entity: GGPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re839 1361
type: Stoichiometry
physical entity: RAC1-GGPP
stoichiometric coefficient: 1.0

UNKNOWN_INHIBITION_LEFT__NPD1-RIGHT__Apoptosis-_re1355
type: Control
xref: UNKNOWN INHIBITION
controlled: Apoptosis
controller: NPD1

AMP
type: SmallMolecule
cellular location: neuron c1

ENAH
type: Protein

STATE_TRANSITION_LEFT__IK-RIGHT__MAPK-_re1046
type: Control
xref: STATE TRANSITION
controlled: MAPK
controller: IK

Ubiquinol
type: SmallMolecule
cellular location: inner membrane c8

HSCoA s676 sa270 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSCoA
stoichiometric coefficient: 1.0

CDC42-GGPP
type: Complex
component: GGPP
component: CDC42
cellular location: neuron c1

L Arginine s158 sa96 STOICHIOMETRY ID
type: Stoichiometry
physical entity: L Arginine s158 sa96
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB-RIGHT__create_AB_channel-_re1264
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: create AB channel
controller: AmyloidB

PARTICIPANT STOICHIOMETRY re35 50
type: Stoichiometry
physical entity: COX
stoichiometric coefficient: 1.0

APBB1-KAT5-SET-AICD
type: Complex
component: APBB1
component: SET
component: KAT5
component: AICD
cellular location: nucleus c3

TLR-AmyloidB
type: Complex
component: TLR
component: AmyloidB
cellular location: microglia c4

STOICHIOMETRY ID s3696 csa296
type: Stoichiometry
physical entity: CD36 AmyloidB s3696 csa296
stoichiometric coefficient: 1.0

unknown
type: Protein
cellular location: neuron c1

NOD1
type: Protein
cellular location: astrocyte c2

PTEN s2369 sa1856 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PTEN
stoichiometric coefficient: 1.0

DAB1 s2092 sa1614 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DAB1
stoichiometric coefficient: 1.0

L-Cysteinesulfinate
type: SmallMolecule
cellular location: mitochondria c7

WNT
type: Protein
cellular location: ER c30

C3A s3490 sa950 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C3A
stoichiometric coefficient: 2.0

ATG12-ATG10
type: Complex
component: ATG12
component: ATG10
cellular location: neuron c1

STATE_TRANSITION_LEFT__AA-RIGHT__unknown-_HPETE-_re112
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re112 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY re112 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY re112 182
conversion direction: LEFT_TO_RIGHT
left: AA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HPETE s402 sa164
right: unknown
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__PRIM1_PCLB_APEX1_POLD1_replication_origin-RIGHT__PRIM1_PCLB_APEX1_POLD1-_re156
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re156 245
participant stoichiometry: PARTICIPANT STOICHIOMETRY re156 246
conversion direction: LEFT_TO_RIGHT
left: PRIM1-PCLB-APEX1-POLD1-replication origin
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PRIM1-PCLB-APEX1-POLD1
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re35 49
type: Stoichiometry
physical entity: COX
stoichiometric coefficient: 1.0

ATG3 s2207 sa1714 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG3
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1250 1981
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 1.0

glutamate-GRIN-Mg2+
type: Complex
component: GRIN
component: Mg2+
component: glutamate s1206 sa1497
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1194 1879
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3343 csa22
type: Stoichiometry
physical entity: APP GAPDH s3343 csa22
stoichiometric coefficient: 1.0

ESR1 s2072 sa1590 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ESR1
stoichiometric coefficient: 1.0

IP3 s3028 sa2379 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

re250 s2042 sa1556 361
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION LEFT Unknown Wnt target genes-RIGHT Unknown Wnt target genes- re250
control type: INHIBITION
controller: ROR

PARTICIPANT STOICHIOMETRY re1194 1880
type: Stoichiometry
physical entity: N APP s3656 sa2571
stoichiometric coefficient: 1.0

MAPK8IP1
type: Protein
cellular location: neuron c1

PPP3
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re405
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re405 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY re405 676
conversion direction: LEFT_TO_RIGHT
left: ATP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: cAMP s1239 sa909
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__Oligomeric_AmyloidB-RIGHT__TIMP1-_H2O2-_re28
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 43
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 44
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 45
conversion direction: LEFT_TO_RIGHT
left: Oligomeric AmyloidB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TIMP1
right: H2O2
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__acetylcholine-_AcetoacetylCoA-RIGHT__HMG_CoA-_re340
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re340 537
participant stoichiometry: PARTICIPANT STOICHIOMETRY re340 538
participant stoichiometry: PARTICIPANT STOICHIOMETRY re340 536
conversion direction: LEFT_TO_RIGHT
left: acetylcholine
left: AcetoacetylCoA s1084 sa788
interaction type: HETERODIMER_ASSOCIATION
right: HMG CoA
xref: HETERODIMER ASSOCIATION

KNOWN_TRANSITION_OMITTED_LEFT__CASP3-RIGHT__Cell_Death-_re71
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Cell Death s119 sa77
controller: CASP3 s68 sa123

PARTICIPANT STOICHIOMETRY re860 1400
type: Stoichiometry
physical entity: PSEN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re860 1401
type: Stoichiometry
physical entity: PSEN
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1250 1983
type: Stoichiometry
physical entity: HSP60 TLR4 s3714 csa303
stoichiometric coefficient: 1.0

C1Q
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re1250 1982
type: Stoichiometry
physical entity: HSP60
stoichiometric coefficient: 1.0

HSPA5
type: Protein
cellular location: endoplasmic reticulum ER c5

STATE_TRANSITION_LEFT__PLG-RIGHT__Plasmin-_re313
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re313 479
participant stoichiometry: PARTICIPANT STOICHIOMETRY re313 478
conversion direction: LEFT_TO_RIGHT
left: PLG
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Plasmin
xref: STATE TRANSITION

CDKN2A
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__AmyloidB1_42-_FPRL1-RIGHT__FPRL1_AmyloidB1_42-_re1212
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1212 1914
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1212 1915
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1212 1916
conversion direction: LEFT_TO_RIGHT
left: AmyloidB1-42
left: FPRL1
interaction type: HETERODIMER_ASSOCIATION
right: FPRL1-AmyloidB1-42
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re1337 2154
type: Stoichiometry
physical entity: GlcNAc6P
stoichiometric coefficient: 1.0

AGER
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re1337 2155
type: Stoichiometry
physical entity: GlcNAc1P
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3176 csa102
type: Stoichiometry
physical entity: NTRK1 NGF s3176 csa102
stoichiometric coefficient: 2.0

XBP1 s2472 sa1935 STOICHIOMETRY ID
type: Stoichiometry
physical entity: XBP1
stoichiometric coefficient: 1.0

VLDLR-RELN
type: Complex
component: VLDLR
component: RELN
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1341 2167
type: Stoichiometry
physical entity: UDP-GlcNAc
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1341 2169
type: Stoichiometry
physical entity: O-GlcNAcylated MAPT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1341 2168
type: Stoichiometry
physical entity: MAPT s3448 sa85
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_TLR9-RIGHT__TLR9_AmyloidB-_re1252
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1252 1987
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1252 1986
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1252 1988
conversion direction: LEFT_TO_RIGHT
left: TLR9
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: TLR9-AmyloidB
spontaneous: true
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__MAPT_-RIGHT__MAPT-_re40
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 79
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 78
conversion direction: LEFT_TO_RIGHT
left: MAPT s3448 sa85
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAPT
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re682 1105
type: Stoichiometry
physical entity: FYN s3455 sa1524
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re682 1104
type: Stoichiometry
physical entity: FYN s3455 sa1523
stoichiometric coefficient: 1.0

RHOA
type: Protein
feature: RHOA RHOA s2043 sa1558 Active
cellular location: neuron c1

ACTA1 s1317 sa980 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACTA1 s1317 sa980
stoichiometric coefficient: 1.0

GSK3B inhibitors
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re114 188
type: Stoichiometry
physical entity: PG s78 sa157
stoichiometric coefficient: 1.0

s3080
type: PhysicalEntity
cellular location: default

PARTICIPANT STOICHIOMETRY re114 189
type: Stoichiometry
physical entity: PG
stoichiometric coefficient: 1.0

FOXO s3457 sa1853 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

WNT
type: RnaRegion
cellular location: nucleus c3

RHOA
type: Protein
cellular location: neuron c1

RAS-Farnesyl PP
type: Complex
component: RAS
component: Farnesyl PP
cellular location: neuron c1

CD36
type: Protein

ADAM
type: Protein
feature: ADAM ADAM s1533 sa37 Active
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__G2_M_checkpoint-RIGHT__M-_re287
type: Interaction
participant: G2/M checkpoint
participant: M
xref: KNOWN TRANSITION OMITTED

STATE_TRANSITION_LEFT__ROS_production-RIGHT__ROS-_re1090
type: Interaction
participant: ROS
participant: ROS production s3047 sa2394
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__ROS_production-RIGHT__ROS-_re1099
type: Interaction
participant: ROS production
participant: ROS
xref: STATE TRANSITION

sa2703 degraded s3792 sa2704 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sa2703 degraded s3792 sa2704
stoichiometric coefficient: 1.0

VCAM1
type: RnaRegion
cellular location: nucleus c3

RELN s2095 sa1618 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RELN s2095 sa1618
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3185 csa42
type: Stoichiometry
physical entity: NCOA-RXR-RARA-ATRA
stoichiometric coefficient: 1.0

RAGE
type: Protein
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__cGMP-RIGHT__protein_synthesis-_re1006
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: protein synthesis
controller: cGMP

STOICHIOMETRY ID s3216 csa118
type: Stoichiometry
physical entity: GUCY1-NO
stoichiometric coefficient: 1.0

NFAT s2437 sa1912 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFAT s2437 sa1912
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re390 641
type: Stoichiometry
physical entity: GTP s1180 sa871
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re390 642
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

HS-
type: SmallMolecule
cellular location: mitochondria c7

sulfate
type: SmallMolecule
cellular location: mitochondria c7

HMGB1
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1341 2170
type: Stoichiometry
physical entity: UDP s3919 sa2836
stoichiometric coefficient: 1.0

CHRFAM7A s773 sa502 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRFAM7A
stoichiometric coefficient: 1.0

Fe
type: SmallMolecule
cellular location: neuron c1

STATE_TRANSITION_LEFT__Oxydosqualene-RIGHT__Lanosterol-_re354
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re354 573
participant stoichiometry: PARTICIPANT STOICHIOMETRY re354 572
conversion direction: LEFT_TO_RIGHT
left: Oxydosqualene
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Lanosterol
xref: STATE TRANSITION

FKBP8
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1311 2073
type: Stoichiometry
physical entity: CN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re580 970
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1311 2072
type: Stoichiometry
physical entity: CN
stoichiometric coefficient: 1.0

ADAM17 s949 sa668 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADAM17
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Li_PLUS_-RIGHT__Li_PLUS_-_re257
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re257 372
participant stoichiometry: PARTICIPANT STOICHIOMETRY re257 373
conversion direction: LEFT_TO_RIGHT
left: Li PLUS s322 sa466
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Li+
xref: TRANSPORT

WNT s255 sa459 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re580 969
type: Stoichiometry
physical entity: CTNNB1 s2840 sa461
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re400 665
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

EIF4EBP1 s2612 sa2079 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EIF4EBP1
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re400 664
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

APP s3931 sa2849 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

GABARAPL2
type: Protein

SLC8A
type: Protein
feature: SLC8A SLC8A s3484 sa2135 Active
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__MAPK-RIGHT__processing-_re1087
type: Interaction
participant: processing s3045 sa2392
participant: MAPK
xref: KNOWN TRANSITION OMITTED

STOICHIOMETRY ID s3249 csa203
type: Stoichiometry
physical entity: PE GABARAPL2 s3249 csa203
stoichiometric coefficient: 1.0

lipid-radical cycles
type: Pathway

CSAD
type: Protein
cellular location: neuron c1

ADRBK1
type: Protein
feature: ADRBK1 ADRBK1 s2140 sa1654 Active
cellular location: neuron c1

SLC8A
type: Protein
cellular location: neuron c1

AKT1S1 s2601 sa2059 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AKT1S1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Met_sulfide_radical_cation-RIGHT__Met_SO-_re364
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re364 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY re364 593
conversion direction: LEFT_TO_RIGHT
left: Met sulfide radical cation
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Met SO
xref: STATE TRANSITION

OSC inhibitor s2382 sa1868 STOICHIOMETRY ID
type: Stoichiometry
physical entity: OSC inhibitor
stoichiometric coefficient: 1.0

K PLUS s1378 sa1047 STOICHIOMETRY ID
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

DKK1-KREMEN2-LRP5/6
type: Complex
component: DKK1
component: LRP5/6
component: KREMEN2
cellular location: neuron c1

CAPN2-mutant PSEN
type: Complex
component: CAPN2
component: mutant PSEN s1437 sa1094
cellular location: endoplasmic reticulum ER c5

KCNIP3
type: Protein
cellular location: endoplasmic reticulum ER c5

PARTICIPANT STOICHIOMETRY re1219 1926
type: Stoichiometry
physical entity: cytokines
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1219 1927
type: Stoichiometry
physical entity: cytokines
stoichiometric coefficient: 1.0

IL6 s2249 sa1748 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

NFKB s3650 sa2560 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKB
stoichiometric coefficient: 1.0

APBA1 s2743 sa2209 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APBA1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Oligomeric_AmyloidB-_RAGE-RIGHT__AB_RAGE-_re1321
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1321 2109
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1321 2108
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1321 2110
conversion direction: LEFT_TO_RIGHT
left: Oligomeric AmyloidB
left: RAGE s3872 sa2789
interaction type: HETERODIMER_ASSOCIATION
right: AB-RAGE
spontaneous: true
xref: HETERODIMER ASSOCIATION

TRANSPORT_LEFT__AmyloidB_ALB-RIGHT__AmyloidB_ALB-_re377
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re377 629
participant stoichiometry: PARTICIPANT STOICHIOMETRY re377 628
conversion direction: LEFT_TO_RIGHT
left: AmyloidB-ALB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: AmyloidB ALB s3194 csa107
xref: TRANSPORT

EDN1 s1639 sa1253 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EDN1
stoichiometric coefficient: 1.0

blood brain barrier BBB c22
type: CellularLocationVocabulary
comment: _blood_brain_barrier__BBB_

Ca2 PLUS s201 sa305 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 3.0

SLC8A s3484 sa2134 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SLC8A
stoichiometric coefficient: 1.0

APBB1-AICD
type: Complex
component: APBB1
component: AICD
cellular location: neuron c1

TRANSCRIPTION_LEFT__RARE_target_genes-RIGHT__RARE_target_genes-_re989
type: TemplateReaction
participant: RARE target genes
product: RARE target genes
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

STATE_TRANSITION_LEFT__5ADHP-_NADPH-RIGHT__NADP_PLUS_-_ALLOP-_re326
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re326 499
participant stoichiometry: PARTICIPANT STOICHIOMETRY re326 502
participant stoichiometry: PARTICIPANT STOICHIOMETRY re326 500
participant stoichiometry: PARTICIPANT STOICHIOMETRY re326 501
conversion direction: LEFT_TO_RIGHT
left: 5ADHP
left: NADPH
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NADP PLUS s1045 sa752
right: ALLOP
xref: STATE TRANSITION

PPP3
type: Protein
feature: PPP3 PPP3 s42 sa1910 Active
cellular location: neuron c1

FPRL1 s3693 sa2606 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FPRL1
stoichiometric coefficient: 1.0

PSEN s1890 sa1412 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSEN
stoichiometric coefficient: 1.0

GABA-GABR
type: Complex
component: GABR
component: GABA
cellular location: postsynaptic density c12

GRIA
type: Protein
feature: GRIA GRIA s3003 sa2358 Active

CASP2 s1766 sa1303 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP2
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3283 csa231
type: Stoichiometry
physical entity: GTPase-GDI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1327 2126
type: Stoichiometry
physical entity: Insulin receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1076 1694
type: Stoichiometry
physical entity: DAG-IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1327 2127
type: Stoichiometry
physical entity: insulin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1076 1695
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

superoxide anion
type: SmallMolecule
cellular location: mitochondria c7

STOICHIOMETRY ID s3112 csa89
type: Stoichiometry
physical entity: 26S Proteasome s3112 csa89
stoichiometric coefficient: 2.0

NMDAR s3852 sa2772 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NMDAR
stoichiometric coefficient: 1.0

TR
type: Protein

zaragozic acid
type: SmallMolecule
cellular location: neuron c1

CACNA1 s60 sa2161 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CACNA1
stoichiometric coefficient: 1.0

NR1H s522 sa198 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NR1H
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3239 csa278
type: Stoichiometry
physical entity: SCAR-AmyloidB fibril
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re818 1322
type: Stoichiometry
physical entity: superoxide anion
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re818 1321
type: Stoichiometry
physical entity: superoxide s2357 sa1840
stoichiometric coefficient: 1.0

CCNE
type: Protein
feature: CCNE CCNE s3449 sa148 Active
cellular location: neuron c1

PUFA
type: SmallMolecule
cellular location: neuron c1

GDP
type: SmallMolecule
cellular location: neuron c1

TLR2
type: Protein
cellular location: neuron c1

TP53 s2799 sa17 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TP53
stoichiometric coefficient: 1.0

NICD-HAT1
type: Complex
component: HAT1
component: NICD
cellular location: nucleus c3

VCAM1 s1623 sa1247 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VCAM1
stoichiometric coefficient: 2.0

FKBP8
type: Protein
feature: FKBP8 FKBP8 s3460 sa2056 Active
cellular location: neuron c1

RARE target genes
type: RnaRegion
cellular location: nucleus c3

AGER
type: Protein
feature: AGER AGER s2682 sa2425 Active

FAS
type: Protein

APOE
type: Protein
cellular location: astrocyte c2

GABA
type: SmallMolecule
cellular location: default

PARTICIPANT STOICHIOMETRY re219 309
type: Stoichiometry
physical entity: UQCR
stoichiometric coefficient: 1.0

TFR
type: Protein
cellular location: neuron c1

APP
type: Protein
cellular location: Lipid raft c32

STATE_TRANSITION_LEFT__PLCB-RIGHT__PLCB-_re19
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 26
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 27
conversion direction: LEFT_TO_RIGHT
left: PLCB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PLCB
xref: STATE TRANSITION

UBE2M-ROC1-UBE2-UB-NEDD8-CUL-SKP1-FBXO
type: Complex
component: SKP1 s794 sa513
component: UBE2M
component: FBXO s798 sa514
component: UBE2
component: CUL
component: UB s1716 sa574
component: ROC1
component: NEDD8 s827 sa510
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re955 1567
type: Stoichiometry
physical entity: CACNA1
stoichiometric coefficient: 1.0

APP s1446 sa1103 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re955 1566
type: Stoichiometry
physical entity: CACNA1
stoichiometric coefficient: 1.0

BACE1
type: DnaRegion
cellular location: neuron c1

Methylcobalamin s1521 sa1166 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Methylcobalamin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re528 881
type: Stoichiometry
physical entity: 5 MTHF s1518 sa1163
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re528 882
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 1.0

5ADHP
type: SmallMolecule
cellular location: astrocyte c2

PARTICIPANT STOICHIOMETRY re528 883
type: Stoichiometry
physical entity: 1-Met
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CASP7-RIGHT__CASP7-_re166
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re166 258
participant stoichiometry: PARTICIPANT STOICHIOMETRY re166 259
conversion direction: LEFT_TO_RIGHT
left: CASP7 s101 sa214
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CASP7 s101 sa217
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re528 880
type: Stoichiometry
physical entity: homo-Cys
stoichiometric coefficient: 1.0

early endosome c17
type: CellularLocationVocabulary
comment: _early_endosome

KNOWN_TRANSITION_OMITTED_LEFT__Oligomeric_AmyloidB-RIGHT__AmyloidB_fibril_formation-_re6
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: AmyloidB fibril formation s407 sa169
controller: Oligomeric AmyloidB

APP s1311 sa973 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

acetoacetate s118 sa266 STOICHIOMETRY ID
type: Stoichiometry
physical entity: acetoacetate
stoichiometric coefficient: 1.0

VLDLR-APOE
type: Complex
component: VLDLR
component: APOE s470 sa315
cellular location: neuron c1

BCHE
type: Protein
cellular location: neuron c1

Met SO
type: SmallMolecule
cellular location: neuron c1

NOD2
type: Protein
cellular location: microglia c4

iNOS s3607 sa2510 STOICHIOMETRY ID
type: Stoichiometry
physical entity: iNOS
stoichiometric coefficient: 1.0

KAT5 s1002 sa712 STOICHIOMETRY ID
type: Stoichiometry
physical entity: KAT5
stoichiometric coefficient: 1.0

phosphatase
type: Protein
feature: phosphatase phosphatase s2151 sa1670 Active
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__sa64_degraded-RIGHT__apoptosis-_re693
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: sa64 degraded s768 sa1543

LAG3
type: Protein

PRKG1
type: Protein
cellular location: postsynaptic density c12

KNOWN_TRANSITION_OMITTED_LEFT__MAPK-RIGHT__expression-_re1088
type: Interaction
participant: MAPK
participant: expression s316 sa140
xref: KNOWN TRANSITION OMITTED

CYC
type: Protein
feature: CYC CYC s463 sa129 rs1
cellular location: mitochondria c7

pyruvate s1327 sa252 STOICHIOMETRY ID
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 2.0

BCL2 s3456 sa1530 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

Lipoprotein remnant
type: SmallMolecule
cellular location: default

IL4-IL4R
type: Complex
component: IL4 s3671 sa2584
component: IL4R
cellular location: microglia c4

protein synthesis
type: Pathway

OSC inhibitor
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re593 995
type: Stoichiometry
physical entity: PRKC s1787 sa1319
stoichiometric coefficient: 1.0

re368 s471 sa174 605
type: Control
xref: UNKNOWN INHIBITION
control type: INHIBITION
controller: PSPHL

PARTICIPANT STOICHIOMETRY re219 310
type: Stoichiometry
physical entity: UQCR
stoichiometric coefficient: 1.0

SORL1 s223 sa131 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SORL1
stoichiometric coefficient: 1.0

re254 s3261 csa58 368
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_RIGHT__APC_GSK3B_AXIN_CTNNB1-_re254
control type: INHIBITION
controller: APC-AXIN-GSK3B-CTNNB1

STATE_TRANSITION_LEFT__some_ions-RIGHT__some_ions-_re1266
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1266 2002
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1266 2001
conversion direction: LEFT_TO_RIGHT
left: some ions
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: some ions
xref: STATE TRANSITION

EIF2AK3
type: Protein
feature: EIF2AK3 EIF2AK3 s2467 sa113 rs1
feature: EIF2AK3 EIF2AK3 s2467 sa113 Active
cellular location: endoplasmic reticulum ER c5

STOICHIOMETRY ID s3315 csa276
type: Stoichiometry
physical entity: PPARA ligands-PPARA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1245 1975
type: Stoichiometry
physical entity: TLRs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1245 1976
type: Stoichiometry
physical entity: DAMPs
stoichiometric coefficient: 1.0

NMDAR s3858 sa2779 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NMDAR
stoichiometric coefficient: 1.0

APAF1
type: Protein
cellular location: neuron c1

CN
type: Protein
feature: CN CN s3849 sa2762 Active
cellular location: neuron c1

oxidative stress s1776 sa1313 STOICHIOMETRY ID
type: Stoichiometry
physical entity: oxidative stress
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3308 csa269
type: Stoichiometry
physical entity: NFKB1 RELA s3308 csa269
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re593 994
type: Stoichiometry
physical entity: PRKC s1786 sa1318
stoichiometric coefficient: 1.0

Mg2+
type: SmallMolecule

PARTICIPANT STOICHIOMETRY re1324 2118
type: Stoichiometry
physical entity: IRS1 s3881 sa2802
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1324 2119
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

CDK5-DCTN5
type: Complex
component: DCTN5
component: CDK5
cellular location: neuron c1

PTEN s2369 sa1855 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PTEN
stoichiometric coefficient: 1.0

CN
type: Protein
cellular location: neuron c1

NTRK3
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1245 1977
type: Stoichiometry
physical entity: TLRs DAMPs s3739 csa305
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3771 csa308
type: Stoichiometry
physical entity: TLR2-DAMPs
stoichiometric coefficient: 1.0

re1279 s3798 sa2710 2020
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSLATION_LEFT__TNF-RIGHT__TNF-_re1279
control type: INHIBITION
controller: PPARG

PARTICIPANT STOICHIOMETRY re840 1363
type: Stoichiometry
physical entity: CDC42 s2386 sa1873
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re909 1509
type: Stoichiometry
physical entity: Fe
stoichiometric coefficient: 1.0

TNFA
type: DnaRegion
cellular location: microglia c4

STOICHIOMETRY ID s3210 csa217
type: Stoichiometry
physical entity: BDNF-NTRK2
stoichiometric coefficient: 1.0

PLA2
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re840 1365
type: Stoichiometry
physical entity: CDC42-GGPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re840 1364
type: Stoichiometry
physical entity: GGPP
stoichiometric coefficient: 1.0

LRP1
type: Protein

STATE_TRANSITION_LEFT__mevalonic_acid-RIGHT__Mevalonate_5_phosphate-_re342
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re342 544
participant stoichiometry: PARTICIPANT STOICHIOMETRY re342 543
conversion direction: LEFT_TO_RIGHT
left: mevalonic acid
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Mevalonate 5 phosphate s1088 sa792
xref: STATE TRANSITION

AmyloidB1-42-C1Q
type: Complex
component: AmyloidB1-42
component: C1Q
cellular location: default

re1278 s3798 sa2710 2019
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSLATION_LEFT__IL1-RIGHT__IL1-_re1278
control type: INHIBITION
controller: PPARG

RXR s716 sa411 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RXR s716 sa411
stoichiometric coefficient: 4.0

PARTICIPANT STOICHIOMETRY re909 1510
type: Stoichiometry
physical entity: Fe s3161 sa2093
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re861 1403
type: Stoichiometry
physical entity: PGGT1B s2387 sa1874
stoichiometric coefficient: 1.0

UNKNOWN_INHIBITION_LEFT__sphingoshine1_P-RIGHT__Apoptosis-_re1358
type: Control
xref: UNKNOWN INHIBITION
controlled: Apoptosis
controller: sphingoshine1-P

NFKBI
type: Protein
feature: NFKBI NFKBI s3473 sa1470 Active

PDK s659 sa256 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PDK s659 sa256
stoichiometric coefficient: 1.0

3-mercaptopyruvate
type: SmallMolecule
cellular location: mitochondria c7

GRI s3008 sa2159 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GRI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re520 863
type: Stoichiometry
physical entity: SMPD2
stoichiometric coefficient: 1.0

EIF2AK3
type: Protein
feature: EIF2AK3 EIF2AK3 s2466 sa1930 rs1
feature: EIF2AK3 EIF2AK3 s2466 sa1930 Active
cellular location: endoplasmic reticulum ER c5

PARTICIPANT STOICHIOMETRY re517 856
type: Stoichiometry
physical entity: SMPD2 s1506 sa1152
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re517 857
type: Stoichiometry
physical entity: SMPD2 s1506 sa1153
stoichiometric coefficient: 1.0

JAK2 s3454 sa1521 STOICHIOMETRY ID
type: Stoichiometry
physical entity: JAK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re520 862
type: Stoichiometry
physical entity: SMPD2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re861 1404
type: Stoichiometry
physical entity: PGGT1B
stoichiometric coefficient: 1.0

MAPK11 s1797 sa1333 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK11 s1797 sa1333
stoichiometric coefficient: 1.0

UNKNOWN_INHIBITION_LEFT__Exendin4-RIGHT__AmyloidB_clearance-_re1356
type: Control
xref: UNKNOWN INHIBITION
controlled: AmyloidB clearance
controller: Exendin4

PARTICIPANT STOICHIOMETRY re600 1012
type: Stoichiometry
physical entity: MAP2K3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re600 1011
type: Stoichiometry
physical entity: MAP2K3 s1794 sa1328
stoichiometric coefficient: 1.0

SolublePRNP s1112 sa815 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SolublePRNP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AGER-_AmyloidB-_re549
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re549 929
participant stoichiometry: PARTICIPANT STOICHIOMETRY re549 930
conversion direction: LEFT_TO_RIGHT
left: AGER
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
xref: HETERODIMER ASSOCIATION

KCN
type: Protein
feature: KCN KCN s2646 sa2106 Active
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__insulin-_NMDAR-RIGHT__Insulin_NMDAR-_re1330
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1330 2129
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1330 2128
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1330 2130
conversion direction: LEFT_TO_RIGHT
left: insulin
left: NMDAR
interaction type: HETERODIMER_ASSOCIATION
right: Insulin-NMDAR
spontaneous: true
xref: HETERODIMER ASSOCIATION

FPRL1
type: Protein
cellular location: microglia c4

ROR s2042 sa1556 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ROR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1056 1657
type: Stoichiometry
physical entity: GRI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1056 1659
type: Stoichiometry
physical entity: GRI-glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1056 1658
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

GUCY1 s1261 sa873 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GUCY1
stoichiometric coefficient: 2.0

UNKNOWN_TRANSITION_LEFT__HMGB1-RIGHT__Inflammation-_re1134
type: Control
xref: UNKNOWN TRANSITION
controlled: Inflammation s167 sa104
controller: HMGB1

HSD17B10
type: Protein
cellular location: mitochondia c13

ACh production
type: Pathway

MAP2K6
type: Protein
cellular location: MAPK cascade c6

HAT1
type: Protein
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re1221 1931
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

NTRK1 s2325 sa1793 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTRK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1221 1932
type: Stoichiometry
physical entity: SRA1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1221 1933
type: Stoichiometry
physical entity: SRA1 AmyloidB s3702 csa297
stoichiometric coefficient: 1.0

AmyloidB
type: Protein
cellular location: Blood c15

STOICHIOMETRY ID s3196 csa108
type: Stoichiometry
physical entity: AmyloidB TTR s3196 csa108
stoichiometric coefficient: 1.0

proNGF
type: Protein
cellular location: default

STATE_TRANSITION_LEFT__ROS-RIGHT__Apoptosis-_re1191
type: Control
xref: STATE TRANSITION
controlled: Apoptosis
controller: ROS

IK
type: PhysicalEntity
feature: IK IK s3464 sa2120 Active
cellular location: neuron c1

BDNF
type: Protein

PARTICIPANT STOICHIOMETRY re277 420
type: Stoichiometry
physical entity: PIK3
stoichiometric coefficient: 1.0

N2
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re462 766
type: Stoichiometry
physical entity: L Cysteinesulfinate s1321 sa984
stoichiometric coefficient: 1.0

ATG12
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re462 767
type: Stoichiometry
physical entity: L-Cysteinesulfinate
stoichiometric coefficient: 1.0

NALP1 s3784 sa2691 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NALP1
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__CCND1-RIGHT__CCND1-_re714
type: TemplateReaction
participant: CCND1
participant: CCND1 s2074 sa1592
product: CCND1 s2074 sa1592
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

TRANSPORT_LEFT__Lipoprotein_remnant-RIGHT__Lipoprotein_remnant-_re621
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re621 1044
participant stoichiometry: PARTICIPANT STOICHIOMETRY re621 1045
conversion direction: LEFT_TO_RIGHT
left: Lipoprotein remnant
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Lipoprotein remnant
xref: TRANSPORT

re853 s133 sa116 1392
type: Control
xref: INHIBITION
control type: INHIBITION
controller: ATF6 s133 sa116

HETERODIMER_ASSOCIATION_LEFT__TLR4_AmyloidB-_AmyloidB-RIGHT__TLR4-_re1162
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1162 1816
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1162 1814
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1162 1815
conversion direction: LEFT_TO_RIGHT
left: AmyloidB
left: TLR4 AmyloidB s3590 csa284
interaction type: HETERODIMER_ASSOCIATION
right: TLR4
xref: HETERODIMER ASSOCIATION

GDP s2496 sa1966 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

GFAT s3915 sa2832 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GFAT s3915 sa2832
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ARL4C-RIGHT__ARL4C-_re850
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re850 1386
participant stoichiometry: PARTICIPANT STOICHIOMETRY re850 1385
conversion direction: LEFT_TO_RIGHT
left: ARL4C
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ARL4C
xref: STATE TRANSITION

Glc6P s3898 sa2817 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Glc6P
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_26S_Proteasome-RIGHT__ADP-_re293
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 455
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 457
conversion direction: LEFT_TO_RIGHT
left: ATP s890 sa613
left: 26S Proteasome s3112 csa89
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ADP
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1007 1636
type: Stoichiometry
physical entity: 60S s1500 sa2328
stoichiometric coefficient: 1.0

KCN
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re277 419
type: Stoichiometry
physical entity: PIK3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1007 1635
type: Stoichiometry
physical entity: 60S
stoichiometric coefficient: 1.0

re348 s2381 sa2295 562
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Farnesyl_PP-RIGHT__Squalene-_re348
control type: INHIBITION
controller: zaragozic acid

HETERODIMER_ASSOCIATION_LEFT__APOE-_AmyloidB-RIGHT__APOE_AmyloidB-_re1095
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1095 1734
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1095 1733
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1095 1732
conversion direction: LEFT_TO_RIGHT
left: AmyloidB s1546 sa1194
left: APOE
interaction type: HETERODIMER_ASSOCIATION
right: APOE-AmyloidB
spontaneous: true
xref: HETERODIMER ASSOCIATION

CD3E s2457 sa1921 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD3E s2457 sa1921
stoichiometric coefficient: 1.0

TLR2-DAMPs
type: Complex
component: TLR2
component: DAMPs s3733 sa2647
cellular location: microglia c4

ORAI1
type: Protein
cellular location: neuron c1

re989 s3186 csa41 1627
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__RARE_target_genes-RIGHT__RARE_target_genes-_re989
control type: INHIBITION
controller: NCOR1-RXR-RARA

selective chaperone translation
type: Pathway

PARTICIPANT STOICHIOMETRY re720 1161
type: Stoichiometry
physical entity: SFK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re720 1160
type: Stoichiometry
physical entity: SFK
stoichiometric coefficient: 1.0

APEX1 s1678 sa406 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APEX1 s1678 sa406
stoichiometric coefficient: 3.0

IDI s1095 sa799 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IDI
stoichiometric coefficient: 1.0

s1577
type: PhysicalEntity
cellular location: Blood c15

CHRM s1018 sa729 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRM
stoichiometric coefficient: 1.0

PRKA
type: Protein

MAP2K3
type: Protein
feature: MAP2K3 MAP2K3 s2819 sa1334 rs1
feature: MAP2K3 MAP2K3 s2819 sa1334 Active
cellular location: MAPK cascade c6

Unknown receptor
type: PhysicalEntity
cellular location: neuron c1

STATE_TRANSITION_LEFT__MTOR-RIGHT__MTOR-_re747
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re747 1199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re747 1198
conversion direction: LEFT_TO_RIGHT
left: MTOR
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MTOR
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re455 751
type: Stoichiometry
physical entity: L-Cystine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re455 750
type: Stoichiometry
physical entity: L-Cys
stoichiometric coefficient: 1.0

UNC13A
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__IL1B-RIGHT__IL1B-_re1204
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1204 1893
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1204 1894
conversion direction: LEFT_TO_RIGHT
left: IL1B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IL1B
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__IL1B-RIGHT__IL1B-_re1205
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1205 1895
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1205 1896
conversion direction: LEFT_TO_RIGHT
left: IL1B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IL1B
xref: STATE TRANSITION

MAP2K7
type: Protein
cellular location: MAPK cascade c6

STATE_TRANSITION_LEFT__speck_like_protein-RIGHT__speck_like_protein-_re1175
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1175 1853
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1175 1854
conversion direction: LEFT_TO_RIGHT
left: speck-like protein
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: speck-like protein
xref: STATE TRANSITION

CD3D s2463 sa2370 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD3D
stoichiometric coefficient: 2.0

AmyloidB1 42 s3506 sa956 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__24_OH_Chol-_NR1H-RIGHT__NR1H_24_OH_Chol-_re149
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re149 233
participant stoichiometry: PARTICIPANT STOICHIOMETRY re149 232
participant stoichiometry: PARTICIPANT STOICHIOMETRY re149 231
conversion direction: LEFT_TO_RIGHT
left: NR1H
left: 24 OH Chol s521 sa202
interaction type: HETERODIMER_ASSOCIATION
right: NR1H-24-OH-Chol
spontaneous: true
xref: HETERODIMER ASSOCIATION

CYC s3169 sa298 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CYC s3169 sa298
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re484 795
type: Stoichiometry
physical entity: sulfite
stoichiometric coefficient: 1.0

cholesterol
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re484 796
type: Stoichiometry
physical entity: sulfite s1346 sa1010
stoichiometric coefficient: 1.0

ATP s3122 sa2127 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP s3122 sa2127
stoichiometric coefficient: 2.0

Lipoprotein remnant s3035 sa2383 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Lipoprotein remnant
stoichiometric coefficient: 7.0

KNOWN_TRANSITION_OMITTED_LEFT__1,3_BPG-RIGHT__TIMP1-_pyruvate-_re201
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re201 286
participant stoichiometry: PARTICIPANT STOICHIOMETRY re201 285
participant stoichiometry: PARTICIPANT STOICHIOMETRY re201 284
conversion direction: LEFT_TO_RIGHT
left: 1,3 BPG s650 sa248
interaction type: KNOWN_TRANSITION_OMITTED
right: TIMP1
right: pyruvate s653 sa251
xref: KNOWN TRANSITION OMITTED

NTF4 s2298 sa1791 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTF4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re477 771
type: Stoichiometry
physical entity: HS-
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1313 2080
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re477 772
type: Stoichiometry
physical entity: thiosulfate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1313 2081
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_TLR2_AmyloidB-RIGHT__TLR2-_re1161
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1161 1813
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1161 1811
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1161 1812
conversion direction: LEFT_TO_RIGHT
left: TLR2-AmyloidB
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: TLR2
xref: HETERODIMER ASSOCIATION

TRNAU1
type: RnaRegion
feature: TRNAU1 TRNAU1 s2379 sa1865 tr1
cellular location: neuron c1

PGGT1B s2387 sa1874 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PGGT1B s2387 sa1874
stoichiometric coefficient: 1.0

NGF
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re330 516
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

RIP s1945 sa1461 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RIP s1945 sa1461
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re330 514
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

ROS production
type: Pathway

PARTICIPANT STOICHIOMETRY re330 515
type: Stoichiometry
physical entity: 5ADHP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re330 513
type: Stoichiometry
physical entity: ALLOP s2869 sa2274
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3269 csa184
type: Stoichiometry
physical entity: SFRP-WNT
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__TP53-RIGHT__apoptosis-_re162
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: TP53

SRA2 s3703 sa2616 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRA2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re525 873
type: Stoichiometry
physical entity: SMPD2 s1506 sa1153
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re885 1448
type: Stoichiometry
physical entity: INPP5K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re885 1449
type: Stoichiometry
physical entity: NICD LAG3 CSHL1 s3184 csa241
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re885 1446
type: Stoichiometry
physical entity: HDAC
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__RAGE_HMGB1-RIGHT__inflammation-_re1285
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: inflammation
controller: RAGE HMGB1 s3805 csa311

APC-AXIN-GSK3B-CTNNB1
type: Complex
component: CTNNB1 s748 sa496
component: GSK3B s3264 sa488
component: APC
component: AXIN
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re885 1447
type: Stoichiometry
physical entity: NCOR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re747 1199
type: Stoichiometry
physical entity: MTOR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re747 1198
type: Stoichiometry
physical entity: MTOR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Met-RIGHT__Met_SO-_re361
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re361 583
participant stoichiometry: PARTICIPANT STOICHIOMETRY re361 584
conversion direction: LEFT_TO_RIGHT
left: Met
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Met SO
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re525 872
type: Stoichiometry
physical entity: SMPD2 s1515 sa1160
stoichiometric coefficient: 1.0

IP3
type: SmallMolecule
cellular location: neuron c1

STATE_TRANSITION_LEFT__GSK3B-RIGHT__GSK3B-_re41
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 83
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 82
conversion direction: LEFT_TO_RIGHT
left: GSK3B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GSK3B
xref: STATE TRANSITION

Na PLUS s1381 sa1050 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 3.0

TRANSLATION_LEFT__ICAM1-RIGHT__ICAM1-_re571
type: TemplateReaction
participant: ICAM1
participant: ICAM1 s1622 sa1246
product: ICAM1 s1622 sa1246
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

TRANSPORT_LEFT__Fe-RIGHT__Fe-_re909
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re909 1509
participant stoichiometry: PARTICIPANT STOICHIOMETRY re909 1510
conversion direction: LEFT_TO_RIGHT
left: Fe
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Fe s3161 sa2093
xref: TRANSPORT

TRANSPORT_LEFT__Fe-RIGHT__Fe-_re908
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re908 1507
participant stoichiometry: PARTICIPANT STOICHIOMETRY re908 1506
conversion direction: LEFT_TO_RIGHT
left: Fe s3161 sa2093
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Fe
xref: TRANSPORT

ADAM10 s3834 sa2743 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADAM10
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PP1-_CAMK2-RIGHT__PP1-_CAMK2-_re1310
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1310 2070
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1310 2067
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1310 2068
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1310 2069
conversion direction: LEFT_TO_RIGHT
left: CAMK2 s2053 sa1570
left: PP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CAMK2 s2053 sa1569
right: PP1
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__APP-RIGHT__C31-_re1058
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1058 1665
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1058 1664
conversion direction: LEFT_TO_RIGHT
left: APP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: C31
xref: STATE TRANSITION

CD3G s2462 sa2369 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD3G
stoichiometric coefficient: 2.0

C3A-AmyloidB1-42
type: Complex
component: C3A s1293 sa949
component: AmyloidB1 42 s1284 sa947
cellular location: default

STATE_TRANSITION_LEFT__MAP3K9_10_11-RIGHT__MAP3K9_10_11-_re627
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re627 1053
participant stoichiometry: PARTICIPANT STOICHIOMETRY re627 1052
conversion direction: LEFT_TO_RIGHT
left: MAP3K9 10 11 s2882 sa1418
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAP3K9/10/11
xref: STATE TRANSITION

BF5 1 s1132 sa832 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BF5-1
stoichiometric coefficient: 1.0

ATG5
type: Protein

PARTICIPANT STOICHIOMETRY re1251 1985
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1251 1984
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

UB s937 sa658 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UB s937 sa658
stoichiometric coefficient: 10.0

AmyloidB fibril s2683 sa2426 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB fibril
stoichiometric coefficient: 2.0

STOICHIOMETRY ID s3704 csa298
type: Stoichiometry
physical entity: SRA2-AmyloidB
stoichiometric coefficient: 1.0

Cl s1383 sa1051 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Cl s1383 sa1051
stoichiometric coefficient: 1.0

WNT1 s2054 sa1775 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT1
stoichiometric coefficient: 1.0

APOE-LPL
type: Complex
component: LPL
component: APOE s470 sa315
cellular location: default

VPS29 s258 sa371 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VPS29
stoichiometric coefficient: 4.0

ceramide-1-P
type: SmallMolecule
cellular location: neuron c1

GPCR homolog
type: Protein
feature: GPCR homolog GPCR homolog s1781 sa1314 rs1
feature: GPCR homolog GPCR homolog s1781 sa1314 Active

CD247 s2458 sa1922 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD247
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PSPHL-RIGHT__PSPHL-_re369
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re369 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY re369 607
conversion direction: LEFT_TO_RIGHT
left: PSPHL
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PSPHL
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re870 1427
type: Stoichiometry
physical entity: GTPase
stoichiometric coefficient: 1.0

ALB s1141 sa839 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ALB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re870 1426
type: Stoichiometry
physical entity: GDI
stoichiometric coefficient: 1.0

re863 s2403 sa2284 1408
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__FNTA-RIGHT__FNTA-_re863
control type: INHIBITION
controller: FTI

PARTICIPANT STOICHIOMETRY re870 1428
type: Stoichiometry
physical entity: GTPase-GDI
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

IL1 s3795 sa2707 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__proMMP9-RIGHT__MMP9-_re314
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re314 483
participant stoichiometry: PARTICIPANT STOICHIOMETRY re314 482
conversion direction: LEFT_TO_RIGHT
left: proMMP9
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MMP9
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__NMDAR-RIGHT__NMDAR-_re1315
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1315 2087
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1315 2086
conversion direction: LEFT_TO_RIGHT
left: NMDAR
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NMDAR
xref: STATE TRANSITION

NOTCH ectodomain
type: Protein
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__Cell_membrane-RIGHT__PS_exposure-_re1043
type: Interaction
participant: PS exposure
participant: Cell membrane
xref: KNOWN TRANSITION OMITTED

NTF
type: SmallMolecule

GTPase s2865 sa2270 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GTPase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re198 274
type: Stoichiometry
physical entity: HK s3486 sa241
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re198 273
type: Stoichiometry
physical entity: HK s3486 sa240
stoichiometric coefficient: 1.0

MME s70 sa61 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MME
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3329 csa25
type: Stoichiometry
physical entity: LDLR AmyloiB1 42 APOE s3329 csa25
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1095 1734
type: Stoichiometry
physical entity: APOE-AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1095 1733
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1095 1732
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

LPL
type: Protein
cellular location: sinusoid c28

Met
type: SmallMolecule
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

HK s3486 sa241 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HK s3486 sa241
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3292 csa258
type: Stoichiometry
physical entity: APP DAB1 s3292 csa258
stoichiometric coefficient: 1.0

HIF s2609 sa2075 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HIF s2609 sa2075
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3282 csa226
type: Stoichiometry
physical entity: TR-LCK-CD4
stoichiometric coefficient: 1.0

MMP s1422 sa1086 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MMP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__RAS-_Farnesyl_PP-RIGHT__RAS_Farnesyl_PP-_re841
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re841 1367
participant stoichiometry: PARTICIPANT STOICHIOMETRY re841 1368
participant stoichiometry: PARTICIPANT STOICHIOMETRY re841 1369
conversion direction: LEFT_TO_RIGHT
left: Farnesyl PP
left: RAS
interaction type: HETERODIMER_ASSOCIATION
right: RAS-Farnesyl PP
spontaneous: true
xref: HETERODIMER ASSOCIATION

ASC s3727 sa2640 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ASC
stoichiometric coefficient: 1.0

C31
type: Protein
cellular location: neuron c1

re249 s2835 csa3 357
type: Control
xref: INHIBITION
controlled: TRANSPORT LEFT CTNNB1-RIGHT CTNNB1- re249
control type: INHIBITION
controller: G-Secretase

DNA fragmentation
type: Pathway

IL6 s2331 sa1745 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re885 1450
type: Stoichiometry
physical entity: INPP5K-CSHL1-HDAC-NCOR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re885 1451
type: Stoichiometry
physical entity: LAG3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re885 1452
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

LEF1 s1706 sa492 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LEF1
stoichiometric coefficient: 2.0

s1577 s1577 sa1214 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s1577
stoichiometric coefficient: 2.0

IL6
type: Protein

PARTICIPANT STOICHIOMETRY re69 121
type: Stoichiometry
physical entity: CASP12
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re69 122
type: Stoichiometry
physical entity: CASP12
stoichiometric coefficient: 1.0

TREM2
type: Protein

glutamate s1192 sa882 STOICHIOMETRY ID
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 3.0

AGER-AmyloidB
type: Complex
component: AGER
component: AmyloidB
cellular location: Blood c15

succinyl CoA s679 sa273 STOICHIOMETRY ID
type: Stoichiometry
physical entity: succinyl-CoA
stoichiometric coefficient: 1.0

HAT1 s2551 sa2020 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HAT1
stoichiometric coefficient: 1.0

LRP1 s3498 sa1195 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP1 s3498 sa1195
stoichiometric coefficient: 1.0

APOE s470 sa315 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APOE s470 sa315
stoichiometric coefficient: 21.0

SMPD2 s1508 sa1155 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SMPD2
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__APBB1-_APP-RIGHT__APP_APBB1-_re21
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 33
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 32
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 31
conversion direction: LEFT_TO_RIGHT
left: APP
left: APBB1
interaction type: HETERODIMER_ASSOCIATION
right: APP-APBB1
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re1321 2110
type: Stoichiometry
physical entity: AB-RAGE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1321 2109
type: Stoichiometry
physical entity: RAGE s3872 sa2789
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1321 2108
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

PRKA s1758 sa1295 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRKA
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__L_Cysteinesulfinate-RIGHT__sulfinyl_pyruvate-_re481
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re481 790
participant stoichiometry: PARTICIPANT STOICHIOMETRY re481 789
conversion direction: LEFT_TO_RIGHT
left: L-Cysteinesulfinate
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sulfinyl pyruvate
xref: STATE TRANSITION

APC s1696 sa470 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 4.0

RHOA s2398 sa1878 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RHOA
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CIB1-_mutant_PSEN-RIGHT__mutant_PSEN_CIB1-_re1071
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1071 1687
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1071 1686
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1071 1685
conversion direction: LEFT_TO_RIGHT
left: mutant PSEN
left: CIB1
interaction type: HETERODIMER_ASSOCIATION
right: mutant PSEN-CIB1
spontaneous: true
xref: HETERODIMER ASSOCIATION

PTGS2 s3466 sa2252 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PTGS2
stoichiometric coefficient: 1.0

CUL s790 sa511 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CUL
stoichiometric coefficient: 4.0

PARTICIPANT STOICHIOMETRY re61 107
type: Stoichiometry
physical entity: PIP3 s171 sa107
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3311 csa240
type: Stoichiometry
physical entity: NICD-HAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re61 106
type: Stoichiometry
physical entity: PI(4,5)P2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re523 869
type: Stoichiometry
physical entity: SMPD2 s1515 sa1160
stoichiometric coefficient: 1.0

SDC2 s2030 sa1550 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SDC2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re523 868
type: Stoichiometry
physical entity: SMPD2 s1510 sa1154
stoichiometric coefficient: 1.0

MAPT
type: Protein
cellular location: neuron c1

ADAM s1533 sa37 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADAM
stoichiometric coefficient: 1.0

PGGT1B s2387 sa1945 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PGGT1B
stoichiometric coefficient: 1.0

CASP6
type: Protein
cellular location: neuron c1

GPCR-oxidative stress
type: Complex
component: GPCR homolog
component: oxidative stress s1780 sa1315
cellular location: neuron c1

CD93 s345 sa356 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD93
stoichiometric coefficient: 1.0

POLB s2951 sa401 STOICHIOMETRY ID
type: Stoichiometry
physical entity: POLB
stoichiometric coefficient: 2.0

CCNE
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__H2O2-RIGHT__H2O-_re963
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re963 1577
participant stoichiometry: PARTICIPANT STOICHIOMETRY re963 1578
conversion direction: LEFT_TO_RIGHT
left: H2O2 s1924 sa1447
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: H2O
xref: STATE TRANSITION

cholesterol s87 sa190 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cholesterol s87 sa190
stoichiometric coefficient: 2.0

TRANSLATION_LEFT__NFKB_responsive_genes-RIGHT__NFKB_responsive_genes-_re716
type: TemplateReaction
participant: NFKB responsive genes
product: NFKB responsive genes
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

NOD1
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re146 222
type: Stoichiometry
physical entity: acetyl CoA s518 sa194
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re146 223
type: Stoichiometry
physical entity: cholesterol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re146 224
type: Stoichiometry
physical entity: geranyl geraniol s539 sa205
stoichiometric coefficient: 1.0

CDK5-IL12A
type: Complex
component: CDK5 s138 sa325
component: IL12A
cellular location: neuron c1

glutamine s3920 sa2837 STOICHIOMETRY ID
type: Stoichiometry
physical entity: glutamine s3920 sa2837
stoichiometric coefficient: 1.0

TNF s2652 sa2111 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 3.0

PRKG1
type: Protein
feature: PRKG1 PRKG1 s3463 sa2104 Active
cellular location: neuron c1

Fe s3161 sa2093 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Fe s3161 sa2093
stoichiometric coefficient: 1.0

SAMe s1524 sa1169 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SAMe
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re978 1608
type: Stoichiometry
physical entity: SHC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re978 1607
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

GUCY1
type: Protein
cellular location: postsynaptic density c12

ENAH s1730 sa1274 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ENAH
stoichiometric coefficient: 1.0

Na PLUS s1379 sa1048 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re978 1609
type: Stoichiometry
physical entity: APP-SHC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re262 388
type: Stoichiometry
physical entity: NEDD8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re867 1416
type: Stoichiometry
physical entity: GDI
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3251 csa154
type: Stoichiometry
physical entity: PSPHL APP APBB1 DAB ENAH cytoskelton s3251 csa154
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re262 387
type: Stoichiometry
physical entity: NEDD8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re867 1415
type: Stoichiometry
physical entity: GDI
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__APPBP1_APP-RIGHT__apoptosis-_re124
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: APPBP1 APP s3324 csa17

PARTICIPANT STOICHIOMETRY re77 145
type: Stoichiometry
physical entity: APP SORL1 s3275 csa13
stoichiometric coefficient: 1.0

WIF1 s2028 sa1548 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WIF1 s2028 sa1548
stoichiometric coefficient: 1.0

HS s1376 sa1045 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HS-
stoichiometric coefficient: 2.0

GNAQ s44 sa48 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GNAQ
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re77 143
type: Stoichiometry
physical entity: SORL1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re810 1304
type: Stoichiometry
physical entity: ceramide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re77 144
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PRKG1
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re810 1305
type: Stoichiometry
physical entity: sphingosine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PE-_GABARAPL2_ATG3-RIGHT__PE_GABARAPL2-_ATG3-_re766
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re766 1241
participant stoichiometry: PARTICIPANT STOICHIOMETRY re766 1242
participant stoichiometry: PARTICIPANT STOICHIOMETRY re766 1243
participant stoichiometry: PARTICIPANT STOICHIOMETRY re766 1244
conversion direction: LEFT_TO_RIGHT
left: PE
left: GABARAPL2-ATG3
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PE GABARAPL2 s3249 csa203
right: ATG3
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__ZAP70-_re1064
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1064 1676
conversion direction: LEFT_TO_RIGHT
left: ZAP70
interaction type: HETERODIMER_ASSOCIATION
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__NR1_NR2BR-RIGHT__NR1_NR2BR-_re1316
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1316 2091
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1316 2092
conversion direction: LEFT_TO_RIGHT
left: NR1 NR2BR s3854 sa2773
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NR1 NR2BR s3854 sa2774
xref: STATE TRANSITION

TNFA s3628 sa2532 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFA
stoichiometric coefficient: 1.0

unknown repressor s2258 sa1756 STOICHIOMETRY ID
type: Stoichiometry
physical entity: unknown repressor s2258 sa1756
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1061 1670
type: Stoichiometry
physical entity: Ubiquinone
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3231 csa133
type: Stoichiometry
physical entity: APP-ACO1-Fe
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__LPL-_SDC2-_APOE-_Lipoprotein_remnant-_LIPC-RIGHT__APOE_SDC2_LIPC_LPL_Lipoprotein_remnant-_re1080
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1080 1707
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1080 1708
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1080 1709
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1080 1710
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1080 1706
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1080 1705
conversion direction: LEFT_TO_RIGHT
left: APOE
left: SDC2
left: Lipoprotein remnant
left: LIPC s1849 sa1380
left: LPL
interaction type: HETERODIMER_ASSOCIATION
right: APOE-SDC2-LIPC-LPL-Lipoprotein remnant
spontaneous: true
xref: HETERODIMER ASSOCIATION

ALLOP
type: SmallMolecule
cellular location: postsynaptic density c12

GSK3B s2878 sa2286 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSK3B s2878 sa2286
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1061 1669
type: Stoichiometry
physical entity: GGPP
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__NICD-RIGHT__NICD-_re304
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re304 465
participant stoichiometry: PARTICIPANT STOICHIOMETRY re304 464
conversion direction: LEFT_TO_RIGHT
left: NICD s972 sa682
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: NICD
xref: TRANSPORT

taurine
type: SmallMolecule
cellular location: neuron c1

STOICHIOMETRY ID s3804 csa310
type: Stoichiometry
physical entity: RAGE AmyloidB s3804 csa310
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__PRKC-RIGHT__PKC_response-_re734
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: PKC response
controller: PRKC s1787 sa1319

PARTICIPANT STOICHIOMETRY re1255 1994
type: Stoichiometry
physical entity: HSP60
stoichiometric coefficient: 1.0

NMDAR s3852 sa2771 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NMDAR
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__JAK2-RIGHT__JAK2-_re681
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re681 1101
participant stoichiometry: PARTICIPANT STOICHIOMETRY re681 1102
conversion direction: LEFT_TO_RIGHT
left: JAK2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: JAK2
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1077 1700
type: Stoichiometry
physical entity: ITPR-IP3
stoichiometric coefficient: 1.0

APP
type: Protein

sa956_degraded
type: PhysicalEntity
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re1255 1993
type: Stoichiometry
physical entity: HSP60
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NO-RIGHT__NO-_re1186
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1186 1871
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1186 1872
conversion direction: LEFT_TO_RIGHT
left: NO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NO s159 sa97
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__NO-RIGHT__NO-_re1187
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1187 1873
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1187 1874
conversion direction: LEFT_TO_RIGHT
left: NO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NO s159 sa97
xref: STATE TRANSITION

PCSK1 s2607 sa2070 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PCSK1 s2607 sa2070
stoichiometric coefficient: 1.0

Met SO s1122 sa823 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Met SO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re544 916
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

HSPA5 s2477 sa1940 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSPA5 s2477 sa1940
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__KCN-RIGHT__KCN-_re918
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re918 1527
participant stoichiometry: PARTICIPANT STOICHIOMETRY re918 1526
conversion direction: LEFT_TO_RIGHT
left: KCN
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: KCN
xref: STATE TRANSITION

UDP GlcNAc s3904 sa2822 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UDP-GlcNAc
stoichiometric coefficient: 1.0

ACTA1 s1315 sa978 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACTA1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re544 917
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PI(4,5)P2
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re981 1617
type: Stoichiometry
physical entity: CASK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re981 1618
type: Stoichiometry
physical entity: CASK
stoichiometric coefficient: 1.0

AGE s3874 sa2792 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AGE
stoichiometric coefficient: 1.0

MAP3K9 10 11 s2881 sa1425 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP3K9/10/11
stoichiometric coefficient: 1.0

PPARA ligands-PPARA
type: Complex
component: PPARA ligands
component: PPARA
cellular location: microglia c4

NFKB
type: Protein
cellular location: neuron c1

ITPR
type: Protein
feature: ITPR ITPR s175 sa329 Active

STOICHIOMETRY ID s3884 csa321
type: Stoichiometry
physical entity: Insulin-IR
stoichiometric coefficient: 2.0

sulfite
type: SmallMolecule
cellular location: neuron c1

PSEN
type: Protein
cellular location: neuron c1

re40 s2763 sa2230 72
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__MAPT_-RIGHT__MAPT-_re40
control type: INHIBITION
controller: IGF1 s2763 sa2230

MAPK12 s1801 sa1339 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK12 s1801 sa1339
stoichiometric coefficient: 1.0

CHRFAM7A s770 sa501 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRFAM7A s770 sa501
stoichiometric coefficient: 1.0

PGE2 s3652 sa2562 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PGE2
stoichiometric coefficient: 1.0

IL1B s1310 sa1115 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B s1310 sa1115
stoichiometric coefficient: 1.0

WIF-WNT
type: Complex
component: WNT
component: WIF1 s2035 sa1551
cellular location: default

TTR s2507 sa848 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TTR
stoichiometric coefficient: 2.0

DAB1
type: Protein
feature: DAB1 DAB1 s2734 sa2203 Active

STATE_TRANSITION_LEFT__MAP2K4-RIGHT__MAP2K4-_re628
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re628 1056
participant stoichiometry: PARTICIPANT STOICHIOMETRY re628 1055
conversion direction: LEFT_TO_RIGHT
left: MAP2K4
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAP2K4
xref: STATE TRANSITION

STOICHIOMETRY ID s3272 csa187
type: Stoichiometry
physical entity: LRP8-RELN
stoichiometric coefficient: 1.0

IDI
type: Protein
cellular location: neuron c1

STOICHIOMETRY ID s3192 csa245
type: Stoichiometry
physical entity: NICD INPP5K CSHL1 HAT1 s3192 csa245
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__HK-RIGHT__HK-_re198
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re198 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY re198 273
conversion direction: LEFT_TO_RIGHT
left: HK s3486 sa240
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HK s3486 sa241
xref: STATE TRANSITION

PDK1 s913 sa634 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PDK1
stoichiometric coefficient: 1.0

O GlcNAcylated MAPT s3918 sa2835 STOICHIOMETRY ID
type: Stoichiometry
physical entity: O-GlcNAcylated MAPT
stoichiometric coefficient: 1.0

EGFR
type: Protein

PARTICIPANT STOICHIOMETRY re342 544
type: Stoichiometry
physical entity: Mevalonate 5 phosphate s1088 sa792
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re342 543
type: Stoichiometry
physical entity: mevalonic acid
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1197 1885
type: Stoichiometry
physical entity: AmyloidB s1136 sa89
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re1197 1886
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

NFKB
type: Protein
feature: NFKB NFKB s3084 sa2441 Active
cellular location: neuron c1

GTP s1259 sa926 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GTP s1259 sa926
stoichiometric coefficient: 1.0

ALLOP s2873 sa2277 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re399 662
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re399 661
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

24 OH Chol s521 sa202 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 24 OH Chol s521 sa202
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__TF_Fe-RIGHT__TF_Fe-_re905
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re905 1500
participant stoichiometry: PARTICIPANT STOICHIOMETRY re905 1501
conversion direction: LEFT_TO_RIGHT
left: TF-Fe
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: TF Fe s3286 csa246
xref: TRANSPORT

BCL2
type: Protein
feature: BCL2 BCL2 s3456 sa1530 Active
cellular location: neuron c1

Oxydosqualene
type: SmallMolecule
cellular location: neuron c1

UNKNOWN_TRANSITION_LEFT__Phagocytosis-RIGHT__TNF-_re10
type: Interaction
participant: TNF
participant: Phagocytosis
xref: UNKNOWN TRANSITION

NFKBI
type: Protein

IL6R
type: Protein
feature: IL6R IL6R s3546 sa1746 Active

CYC s463 sa129 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CYC
stoichiometric coefficient: 1.0

cholesterol
type: SmallMolecule
cellular location: astrocyte c2

ATG10
type: Protein
cellular location: neuron c1

re372 s48 sa844 616
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__TTR-RIGHT__TTR-_re372
control type: INHIBITION
controller: TNF

STOICHIOMETRY ID s3267 csa181
type: Stoichiometry
physical entity: UB-Unknown
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__excitotoxin-RIGHT__neurotoxin-_re1106
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: neurotoxin s3062 sa2418
controller: excitotoxin s3058 sa2410

SNCA s50 sa51 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SNCA s50 sa51
stoichiometric coefficient: 1.0

TLR9
type: Protein

BCL2L1
type: Protein
cellular location: inner membrane c8

PARTICIPANT STOICHIOMETRY re757 1220
type: Stoichiometry
physical entity: ATG7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re757 1221
type: Stoichiometry
physical entity: ATG12-ATG10
stoichiometric coefficient: 1.0

DKK1
type: Protein
feature: DKK1 DKK1 s1740 sa1279 Active

IL6 s3468 sa2447 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 2.0

KNOWN_TRANSITION_OMITTED_LEFT__tissue_injured-RIGHT__PAMPs-_re1249
type: Interaction
participant: tissue injured
participant: PAMPs
xref: KNOWN TRANSITION OMITTED

CASP7 s101 sa214 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP7 s101 sa214
stoichiometric coefficient: 1.0

chemotaxis s3688 sa2602 STOICHIOMETRY ID
type: Stoichiometry
physical entity: chemotaxis s3688 sa2602
stoichiometric coefficient: 1.0

acetoacetate s670 sa265 STOICHIOMETRY ID
type: Stoichiometry
physical entity: acetoacetate s670 sa265
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__activate_microglia_inflammatory_processes-_re426
type: Interaction
participant: Microglia Activation
participant: activate microglia inflammatory processes
xref: KNOWN TRANSITION OMITTED

Notch site3 cleavaged protien s965 sa675 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Notch site3 cleavaged protien
stoichiometric coefficient: 1.0

GSSG PLUS HS s1368 sa1034 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSSG+HS-
stoichiometric coefficient: 1.0

Mevalonate PP
type: SmallMolecule
cellular location: neuron c1

Delta s974 sa686 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Delta
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__CLU-_AmyloidB-RIGHT__AmyloidB_CLU-_re546
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re546 923
participant stoichiometry: PARTICIPANT STOICHIOMETRY re546 922
participant stoichiometry: PARTICIPANT STOICHIOMETRY re546 921
conversion direction: LEFT_TO_RIGHT
left: AmyloidB
left: CLU
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB CLU s3243 csa148
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re757 1218
type: Stoichiometry
physical entity: ATG12-ATG7
stoichiometric coefficient: 1.0

NGF s1015 sa726 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NGF
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3503 csa124
type: Stoichiometry
physical entity: C3A AmyloidB1 42 s3503 csa124
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3702 csa297
type: Stoichiometry
physical entity: SRA1 AmyloidB s3702 csa297
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__O2-_sulfite-RIGHT__sulfate-_re483
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re483 794
participant stoichiometry: PARTICIPANT STOICHIOMETRY re483 793
participant stoichiometry: PARTICIPANT STOICHIOMETRY re483 792
conversion direction: LEFT_TO_RIGHT
left: sulfite s1346 sa1010
left: O2
interaction type: HETERODIMER_ASSOCIATION
right: sulfate
xref: HETERODIMER ASSOCIATION

AICD
type: Protein

PARTICIPANT STOICHIOMETRY re313 479
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re313 478
type: Stoichiometry
physical entity: PLG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re757 1219
type: Stoichiometry
physical entity: ATG10
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re37 54
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

UBE2-UB
type: Complex
component: UBE2
component: UB
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re37 55
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

NCOR1
type: Protein

PARTICIPANT STOICHIOMETRY re22 36
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re22 35
type: Stoichiometry
physical entity: AmyloidB1-40
stoichiometric coefficient: 1.0

CASP6
type: Protein
feature: CASP6 CASP6 s93 sa216 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re66 116
type: Stoichiometry
physical entity: ERN1
stoichiometric coefficient: 2.0

s49 s2552 sa2015 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s49 s2552 sa2015
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re66 115
type: Stoichiometry
physical entity: ERN1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__UB-RIGHT__UB-_re296
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re296 460
participant stoichiometry: PARTICIPANT STOICHIOMETRY re296 459
conversion direction: LEFT_TO_RIGHT
left: UB s937 sa658
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: UB s892 sa603
xref: STATE TRANSITION

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

IL1B
type: Protein
cellular location: default

STATE_TRANSITION_LEFT__IPP-_DMAPP-RIGHT__GPP-_re346
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re346 557
participant stoichiometry: PARTICIPANT STOICHIOMETRY re346 555
participant stoichiometry: PARTICIPANT STOICHIOMETRY re346 556
conversion direction: LEFT_TO_RIGHT
left: DMAPP
left: IPP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GPP
xref: STATE TRANSITION

re623 s267 sa468 1046
type: Control
xref: INHIBITION
control type: INHIBITION
controller: CTNNB1

PARTICIPANT STOICHIOMETRY re1212 1914
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 1.0

ADAM
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re1212 1915
type: Stoichiometry
physical entity: FPRL1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1212 1916
type: Stoichiometry
physical entity: FPRL1-AmyloidB1-42
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1159 1805
type: Stoichiometry
physical entity: AGEs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1159 1806
type: Stoichiometry
physical entity: RAGE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1159 1807
type: Stoichiometry
physical entity: RAGE-AGEs
stoichiometric coefficient: 1.0

K+
type: SmallMolecule
cellular location: default

LDLR s491 sa379 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LDLR s491 sa379
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PRKG1-RIGHT__PRKG1-_re917
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re917 1523
participant stoichiometry: PARTICIPANT STOICHIOMETRY re917 1524
conversion direction: LEFT_TO_RIGHT
left: PRKG1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PRKG1
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB1_42-RIGHT__synaptic_dysfunction-_re423
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: synaptic dysfunction s1277 sa940
controller: AmyloidB1 42 s1280 sa944

ATG13 s2150 sa1661 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG13
stoichiometric coefficient: 1.0

G2/M checkpoint
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB_fibril_formation-RIGHT__Neuro_toxicity-_re130
type: Interaction
participant: Neuro-toxicity
participant: AmyloidB fibril formation s407 sa169
xref: KNOWN TRANSITION OMITTED

SET
type: Protein

O acetylhomoserine aminocarboxypropyltransferase s1522 sa1167 STOICHIOMETRY ID
type: Stoichiometry
physical entity: O acetylhomoserine aminocarboxypropyltransferase s1522 sa1167
stoichiometric coefficient: 1.0

MT ND s186 sa281 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MT-ND
stoichiometric coefficient: 1.0

NAD+
type: SmallMolecule
cellular location: neuron c1

APAF1 s615 sa409 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re227 331
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re227 330
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

RAC1
type: Protein
cellular location: neuron c1

CHRM
type: Protein
cellular location: neuron c1

PLCB s45 sa1906 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLCB
stoichiometric coefficient: 1.0

re932 s2704 sa2181 1549
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ATP1-RIGHT__ATP1-_re932
control type: INHIBITION
controller: HNE

ALLOP s2872 sa2275 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MT_ND-RIGHT__MT_ND-_Ubiquinol-_re218
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re218 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY re218 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY re218 304
conversion direction: LEFT_TO_RIGHT
left: MT-ND
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MT-ND
right: Ubiquinol
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__UB-_UBA1-RIGHT__UBA1_UB-_re271
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re271 400
participant stoichiometry: PARTICIPANT STOICHIOMETRY re271 398
participant stoichiometry: PARTICIPANT STOICHIOMETRY re271 399
conversion direction: LEFT_TO_RIGHT
left: UB s892 sa603
left: UBA1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: UBA1-UB
xref: STATE TRANSITION

DAG
type: SmallMolecule

NOD2 s3664 sa2581 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOD2 s3664 sa2581
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re933
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re933 1553
participant stoichiometry: PARTICIPANT STOICHIOMETRY re933 1554
conversion direction: LEFT_TO_RIGHT
left: Na+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Na+
xref: TRANSPORT

TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re935
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re935 1559
participant stoichiometry: PARTICIPANT STOICHIOMETRY re935 1558
conversion direction: LEFT_TO_RIGHT
left: Na+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: Na+
xref: TRANSPORT

NO s3508 sa2411 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

N1 s1115 sa820 STOICHIOMETRY ID
type: Stoichiometry
physical entity: N1
stoichiometric coefficient: 1.0

unknown PPARG ligand
type: PhysicalEntity
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re1293 2047
type: Stoichiometry
physical entity: 16,17S-DHA Epoxide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1293 2048
type: Stoichiometry
physical entity: NPD1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re227 329
type: Stoichiometry
physical entity: Q
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Oligomeric_AmyloidB-RIGHT__Ca2_PLUS__increase-_re1145
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Ca2+ increase
controller: Oligomeric AmyloidB

NR1 NR2BR s3854 sa2774 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NR1 NR2BR s3854 sa2774
stoichiometric coefficient: 1.0

ATP2 s3524 sa2125 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP2 s3524 sa2125
stoichiometric coefficient: 1.0

ROC1 s797 sa512 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ROC1
stoichiometric coefficient: 4.0

PARTICIPANT STOICHIOMETRY re1309 2064
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3245 csa150
type: Stoichiometry
physical entity: AGER AmyloidB CAV1 s3245 csa150
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1309 2063
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

C3
type: RnaRegion
cellular location: default

PSPHL s1658 sa1270 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSPHL
stoichiometric coefficient: 1.0

cell surviving response
type: Pathway

MY
type: Protein
feature: MY MY s2045 sa1561 Active
cellular location: neuron c1

MAPK14
type: Protein
feature: MAPK14 MAPK14 s15 sa1329 Active
feature: MAPK14 MAPK14 s15 sa1329 rs1
cellular location: MAPK cascade c6

sulfinyl pyruvate s1372 sa1038 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sulfinyl pyruvate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__HMGB1-RIGHT__HMGB1-_re1132
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1132 1780
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1132 1779
conversion direction: LEFT_TO_RIGHT
left: HMGB1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HMGB1
xref: STATE TRANSITION

re748 s2152 sa1669 1200
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__phosphatase-RIGHT__phosphatase-_re748
control type: INHIBITION
controller: MTOR

TNF
type: Protein
cellular location: default

IGF1 s2763 sa2230 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IGF1 s2763 sa2230
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1189 1877
type: Stoichiometry
physical entity: ROS s3621 sa2521
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1189 1878
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

VCAM1
type: DnaRegion
cellular location: nucleus c3

WNT s2064 sa1581 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT
stoichiometric coefficient: 1.0

SMPD2 s1511 sa1156 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SMPD2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re551 934
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re551 933
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

R S s1370 sa1036 STOICHIOMETRY ID
type: Stoichiometry
physical entity: R S s1370 sa1036
stoichiometric coefficient: 1.0

re66 s3025 sa2376 114
type: Control
xref: INHIBITION
controlled: STATE TRANSITION LEFT ERN1-RIGHT ERN1- re66
control type: INHIBITION
controller: mutant PSEN

PARTICIPANT STOICHIOMETRY re842 1372
type: Stoichiometry
physical entity: RYR3 s3145 sa1891
stoichiometric coefficient: 1.0

MY
type: Protein
cellular location: neuron c1

PLCG s2946 sa2319 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLCG
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s237 csa40
type: Stoichiometry
physical entity: s225
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ACh_production-RIGHT__ACh-_re1126
type: Interaction
participant: ACh production
participant: ACh
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re842 1373
type: Stoichiometry
physical entity: RYR3
stoichiometric coefficient: 1.0

PPARG
type: Protein
cellular location: neuron c1

CAPN2 s2418 sa1893 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CAPN2
stoichiometric coefficient: 1.0

TLR s3588 sa2495 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLR
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__preautophagosomal_membrane-RIGHT__autophagosome_formation-_re762
type: Interaction
participant: preautophagosomal membrane s2188 sa1695
participant: autophagosome formation
xref: KNOWN TRANSITION OMITTED

STATE_TRANSITION_LEFT__UQCR-RIGHT__UQCR-_re219
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re219 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY re219 309
conversion direction: LEFT_TO_RIGHT
left: UQCR
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: UQCR
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__TUB-RIGHT__microtubules-_re289
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re289 442
participant stoichiometry: PARTICIPANT STOICHIOMETRY re289 441
conversion direction: LEFT_TO_RIGHT
left: TUB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: microtubules
xref: STATE TRANSITION

NE s1527 sa1172 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

NAD PLUS s1061 sa769 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NAD PLUS s1061 sa769
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__IL1B-RIGHT__Neuronal_injury-_re13
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Neuronal injury
controller: IL1B

ATG11
type: Protein
cellular location: neuron c1

cGMP s2645 sa2102 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3871 csa319
type: Stoichiometry
physical entity: AB-RAGE
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__hypotaurine-RIGHT__taurine-_re451
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re451 741
participant stoichiometry: PARTICIPANT STOICHIOMETRY re451 740
conversion direction: LEFT_TO_RIGHT
left: hypotaurine
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: taurine
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__APBA1-_APP-RIGHT__APP_APBA1-_re979
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re979 1611
participant stoichiometry: PARTICIPANT STOICHIOMETRY re979 1612
participant stoichiometry: PARTICIPANT STOICHIOMETRY re979 1610
conversion direction: LEFT_TO_RIGHT
left: APP
left: APBA1
interaction type: HETERODIMER_ASSOCIATION
right: APP-APBA1
spontaneous: true
xref: HETERODIMER ASSOCIATION

Oligomeric AmyloidB
type: Protein
cellular location: inner membrane c8

CHRN-AmyloidB
type: Complex
component: CHRN s2668 sa2124
component: AmyloidB
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_SRA2-RIGHT__SRA2_AmyloidB-_re1222
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1222 1935
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1222 1934
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1222 1936
conversion direction: LEFT_TO_RIGHT
left: SRA2
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: SRA2-AmyloidB
spontaneous: true
xref: HETERODIMER ASSOCIATION

Golgi apparatus c20
type: CellularLocationVocabulary
comment: _Golgi_apparatus

STOICHIOMETRY ID s3301 csa244
type: Stoichiometry
physical entity: HDAC-NCOR2
stoichiometric coefficient: 1.0

SRA1 s3701 sa2615 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRA1
stoichiometric coefficient: 1.0

TTR
type: Protein
cellular location: CSF c16

C3 s1301 sa963 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C3 s1301 sa963
stoichiometric coefficient: 1.0

24 OH Chol s524 sa389 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 24-OH-Chol
stoichiometric coefficient: 1.0

ATG16
type: Protein

STATE_TRANSITION_LEFT__SPHK1-RIGHT__SPHK1-_re812
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re812 1307
participant stoichiometry: PARTICIPANT STOICHIOMETRY re812 1306
conversion direction: LEFT_TO_RIGHT
left: SPHK1 s2344 sa1822
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: SPHK1 s2344 sa1823
xref: STATE TRANSITION

IL6R s2239 sa1741 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6R
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__G2-RIGHT__M-_re83
type: Interaction
participant: G2
participant: M
xref: KNOWN TRANSITION OMITTED

IDE
type: Protein
cellular location: microglia c4

re890 s2606 sa2069 1460
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__TSC-RIGHT__TSC-_re890
control type: INHIBITION
controller: RPS6KA1

PARTICIPANT STOICHIOMETRY re1332 2138
type: Stoichiometry
physical entity: glucose
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re533 892
type: Stoichiometry
physical entity: Trp s1529 sa1174
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1332 2137
type: Stoichiometry
physical entity: glucose
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re533 893
type: Stoichiometry
physical entity: 5-HT
stoichiometric coefficient: 1.0

TLR4
type: Protein

40S
type: Protein
cellular location: neuron c1

re862 s2375 sa1861 1405
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__HMGCR-RIGHT__HMGCR-_re862
control type: INHIBITION
controller: HMGCRI

APP
type: PhysicalEntity
cellular location: default

cGMP s1272 sa936 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cGMP s1272 sa936
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re413 695
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re413 696
type: Stoichiometry
physical entity: 5'GMP
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3330 csa27
type: Stoichiometry
physical entity: TNFRSF21 N APP s3330 csa27
stoichiometric coefficient: 1.0

EIF2AK3 s2467 sa113 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 1.0

RAS
type: Protein

PARTICIPANT STOICHIOMETRY re131 202
type: Stoichiometry
physical entity: AmyloidB1-42-APOE
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__NTF3-_NTRK3-RIGHT__NTRK3_NTF-_re795
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re795 1279
participant stoichiometry: PARTICIPANT STOICHIOMETRY re795 1281
participant stoichiometry: PARTICIPANT STOICHIOMETRY re795 1280
conversion direction: LEFT_TO_RIGHT
left: NTRK3
left: NTF3
interaction type: HETERODIMER_ASSOCIATION
right: NTRK3-NTF
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re131 201
type: Stoichiometry
physical entity: APOE s607 sa177
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re131 200
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 1.0

UQCR
type: Protein
feature: UQCR UQCR s192 sa286 Active
cellular location: inner membrane c8

NADH
type: SmallMolecule
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__synaptic_plasticity-RIGHT__memory-_re416
type: Interaction
participant: synaptic plasticity
participant: memory s1265 sa931
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re835 1348
type: Stoichiometry
physical entity: IPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re835 1347
type: Stoichiometry
physical entity: DMAPP
stoichiometric coefficient: 1.0

s3841 s3841 sa2750 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s3841
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re445 731
type: Stoichiometry
physical entity: APOE s607 sa177
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re445 730
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

HMGCS
type: Protein
cellular location: neuron c1

NFKB s3632 sa2626 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKB
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__cholesterol-RIGHT__cholesterol-_re140
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re140 215
participant stoichiometry: PARTICIPANT STOICHIOMETRY re140 216
conversion direction: LEFT_TO_RIGHT
left: cholesterol s3164 sa188
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: cholesterol s87 sa190
xref: TRANSPORT

KNOWN_TRANSITION_OMITTED_LEFT__Ca2_PLUS_-RIGHT__apoptosis-_re968
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: Ca2+

IL4R
type: Protein
cellular location: microglia c4

IK
type: PhysicalEntity
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1333 2141
type: Stoichiometry
physical entity: Glc6P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1333 2140
type: Stoichiometry
physical entity: glucose
stoichiometric coefficient: 1.0

UQCR
type: Protein
cellular location: inner membrane c8

ACh s1023 sa732 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

GRI
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__ITAM-_re849
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re849 1384
conversion direction: LEFT_TO_RIGHT
left: ITAM
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
xref: STATE TRANSITION

FTH
type: RnaRegion

PGGT1B
type: Protein
feature: PGGT1B PGGT1B s2387 sa1945 Active
cellular location: neuron c1

autophagy induction
type: Pathway

unknown PPARG ligand
type: PhysicalEntity

APBB1
type: Protein
cellular location: neuron c1

COX
type: Protein
cellular location: inner membrane c8

TRANSLATION_LEFT__IL1-RIGHT__IL1-_re1278
type: TemplateReaction
participant: IL1 s3794 sa2706
participant: IL1
product: IL1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

PARTICIPANT STOICHIOMETRY re937 1563
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

LDLR
type: Protein

estrogen s906 sa622 STOICHIOMETRY ID
type: Stoichiometry
physical entity: estrogen
stoichiometric coefficient: 2.0

NTRK3-NTF
type: Complex
component: NTRK3
component: NTF3
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re486 803
type: Stoichiometry
physical entity: CBS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re486 802
type: Stoichiometry
physical entity: CBS
stoichiometric coefficient: 1.0

TNFA
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re937 1562
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Unknown Wnt target genes s1707 sa490 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Unknown Wnt-target genes
stoichiometric coefficient: 1.0

KCNIP3 s2426 sa1900 STOICHIOMETRY ID
type: Stoichiometry
physical entity: KCNIP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re977 1606
type: Stoichiometry
physical entity: APP DAB1 s3292 csa258
stoichiometric coefficient: 1.0

COX
type: Protein
feature: COX COX s2814 sa2255 Active
cellular location: inner membrane c8

BCL2
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re977 1605
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re977 1604
type: Stoichiometry
physical entity: DAB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re143 220
type: Stoichiometry
physical entity: TIMP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re670 1099
type: Stoichiometry
physical entity: glutamate-GRIN-Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re670 1098
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

DAG-IP3
type: Complex
component: DAG
component: IP3
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re670 1097
type: Stoichiometry
physical entity: GRIN-Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re710 1146
type: Stoichiometry
physical entity: WNT s2065 sa1583
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re710 1147
type: Stoichiometry
physical entity: WNT
stoichiometric coefficient: 1.0

RELA
type: Protein

ARL4C s2808 sa1929 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ARL4C
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1034 1644
type: Stoichiometry
physical entity: Oligomeric AmyloidB-HSD17B10
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1034 1643
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re1034 1642
type: Stoichiometry
physical entity: HSD17B10
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re143 219
type: Stoichiometry
physical entity: cholesterol
stoichiometric coefficient: 5.0

EIF2A s2470 sa1932 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EIF2A
stoichiometric coefficient: 1.0

RPS6KA1
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_RAGE-RIGHT__RAGE_AmyloidB-_re1163
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1163 1819
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1163 1817
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1163 1818
conversion direction: LEFT_TO_RIGHT
left: RAGE
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: RAGE-AmyloidB
spontaneous: true
xref: HETERODIMER ASSOCIATION

KNOWN_TRANSITION_OMITTED_LEFT__C3A_AmyloidB1_42-RIGHT__Microglia_Activation-_re430
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Microglia Activation
controller: C3A AmyloidB1 42 s3503 csa124

STATE_TRANSITION_LEFT__PCSK1-RIGHT__PCSK1-_re899
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re899 1481
participant stoichiometry: PARTICIPANT STOICHIOMETRY re899 1482
conversion direction: LEFT_TO_RIGHT
left: PCSK1 s2607 sa2070
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PCSK1 s2607 sa2071
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re755 1214
type: Stoichiometry
physical entity: ATG12
stoichiometric coefficient: 1.0

Li PLUS s319 sa465 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Li+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re755 1213
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__APOE_LPL-_PSPHL-_AmyloidB1_40-RIGHT__LRP1_AmyloidB_APOE_LPL-_re127
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re127 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY re127 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY re127 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re127 195
conversion direction: LEFT_TO_RIGHT
left: AmyloidB1-40
left: PSPHL
left: APOE-LPL
interaction type: HETERODIMER_ASSOCIATION
right: LRP1 AmyloidB APOE LPL s3369 csa4
spontaneous: true
xref: HETERODIMER ASSOCIATION

PK s2332 sa1808 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PK s2332 sa1808
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re449 737
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re449 738
type: Stoichiometry
physical entity: L-Cys
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re449 739
type: Stoichiometry
physical entity: L Cysteinesulfinate s1321 sa984
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re755 1211
type: Stoichiometry
physical entity: ATP s890 sa613
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re755 1212
type: Stoichiometry
physical entity: ATG12
stoichiometric coefficient: 1.0

re495 s2605 sa2067 819
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__RAS-RIGHT__RAS-_re495
control type: INHIBITION
controller: NF1 s2605 sa2067

LRP1 s1842 sa312 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP1
stoichiometric coefficient: 3.0

HETERODIMER_ASSOCIATION_LEFT__GAPDH-_APP-RIGHT__APP_GAPDH-_re163
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re163 253
participant stoichiometry: PARTICIPANT STOICHIOMETRY re163 252
participant stoichiometry: PARTICIPANT STOICHIOMETRY re163 251
conversion direction: LEFT_TO_RIGHT
left: GAPDH s2817 sa2256
left: APP
interaction type: HETERODIMER_ASSOCIATION
right: APP GAPDH s3343 csa22
spontaneous: true
xref: HETERODIMER ASSOCIATION

RPS6KA1
type: Protein
feature: RPS6KA1 RPS6KA1 s2606 sa2069 Active
cellular location: neuron c1

AmyloidB s1136 sa89 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB s1136 sa89
stoichiometric coefficient: 30.0

MMP s1421 sa1085 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MMP
stoichiometric coefficient: 1.0

RELN s3558 sa1622 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RELN
stoichiometric coefficient: 2.0

A2MLRP
type: Complex
component: A2M
component: LRP s3867 sa2786
cellular location: BBB c25

ADCY10-CALM-Ca2+
type: Complex
component: ADCY10
component: Ca2+
component: CALM
cellular location: postsynaptic density c12

IKBK
type: Protein
feature: IKBK IKBK s2081 sa1452 rs1
feature: IKBK IKBK s2081 sa1452 Active
cellular location: neuron c1

STOICHIOMETRY ID s3273 csa188
type: Stoichiometry
physical entity: LRP8-APOE
stoichiometric coefficient: 1.0

mutant PSEN
type: Protein
cellular location: endoplasmic reticulum ER c5

HETERODIMER_ASSOCIATION_LEFT__ADCY10-_CALM_Ca2_PLUS_-RIGHT__ADCY10_CALM_Ca2_PLUS_-_re404
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re404 672
participant stoichiometry: PARTICIPANT STOICHIOMETRY re404 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY re404 673
conversion direction: LEFT_TO_RIGHT
left: ADCY10 s1229 sa905
left: CALM Ca2 PLUS s3214 csa116
interaction type: HETERODIMER_ASSOCIATION
right: ADCY10-CALM-Ca2+
spontaneous: true
xref: HETERODIMER ASSOCIATION

HMGCR
type: Protein
feature: HMGCR HMGCR s1087 sa791 Active
cellular location: neuron c1

STATE_TRANSITION_LEFT__FKBP8-RIGHT__FKBP8-_re892
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re892 1469
participant stoichiometry: PARTICIPANT STOICHIOMETRY re892 1468
conversion direction: LEFT_TO_RIGHT
left: FKBP8
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FKBP8
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__superoxide_anion-RIGHT__H2O2-_re816
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re816 1318
participant stoichiometry: PARTICIPANT STOICHIOMETRY re816 1317
conversion direction: LEFT_TO_RIGHT
left: superoxide anion
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: H2O2 s1924 sa1447
xref: STATE TRANSITION

NADH s1049 sa756 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 2.0

ULK1 s2160 sa1679 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ULK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re565 955
type: Stoichiometry
physical entity: ICAM1 s1622 sa1246
stoichiometric coefficient: 1.0

STATE_TRANSITION_RIGHT__APC_GSK3B_AXIN_CTNNB1-_re254
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re254 369
conversion direction: LEFT_TO_RIGHT
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APC-GSK3B-AXIN-CTNNB1
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re565 956
type: Stoichiometry
physical entity: ICAM1 s1622 sa1246
stoichiometric coefficient: 1.0

TREM1-DAP12
type: Complex
component: DAP12
component: TREM1
cellular location: microglia c4

FDFT1 s1101 sa805 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FDFT1
stoichiometric coefficient: 1.0

Phagocytosis
type: Pathway

IL1B s3645 sa2555 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 26
type: Stoichiometry
physical entity: PLCB
stoichiometric coefficient: 1.0

CSHL1 s2572 sa2025 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CSHL1
stoichiometric coefficient: 5.0

PARTICIPANT STOICHIOMETRY re19 27
type: Stoichiometry
physical entity: PLCB
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CLU-_AmyloidB-RIGHT__AmyloidB_CLU-_re1026
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1026 1639
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1026 1638
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1026 1637
conversion direction: LEFT_TO_RIGHT
left: AmyloidB s1546 sa1194
left: CLU
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB CLU s3244 csa263
spontaneous: true
xref: HETERODIMER ASSOCIATION

Neuron No.2 c10
type: CellularLocationVocabulary
comment: _Neuron_No.2

STXBP1
type: Protein
cellular location: neuron c1

JUN s1898 sa1419 STOICHIOMETRY ID
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__PS_exposure-RIGHT__Abnormal_cell_function-_re1044
type: Interaction
participant: PS exposure
participant: Abnormal cell function s2988 sa2351
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re161 249
type: Stoichiometry
physical entity: TP53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1080 1707
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re746 1190
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1080 1708
type: Stoichiometry
physical entity: Lipoprotein remnant
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re746 1191
type: Stoichiometry
physical entity: PEBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1080 1709
type: Stoichiometry
physical entity: LIPC s1849 sa1380
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Microglia_Activation-RIGHT__Generation_of_reactive_oxygen_species-_re998
type: Interaction
participant: Microglia Activation
participant: Generation of reactive oxygen species
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re409 683
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re746 1192
type: Stoichiometry
physical entity: RAF1-PEBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re409 684
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

hypotaurine s1322 sa986 STOICHIOMETRY ID
type: Stoichiometry
physical entity: hypotaurine
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3205 csa196
type: Stoichiometry
physical entity: ATG12-ATG7
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__KREMEN2-_DKK1-_LRP5_6-RIGHT__DKK1_KREMEN2_LRP5_6-_re578
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 965
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 964
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 963
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 962
conversion direction: LEFT_TO_RIGHT
left: DKK1 s1749 sa1283
left: LRP5/6
left: KREMEN2
interaction type: HETERODIMER_ASSOCIATION
right: DKK1-KREMEN2-LRP5/6
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re1131 1777
type: Stoichiometry
physical entity: MIF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1131 1776
type: Stoichiometry
physical entity: MIF
stoichiometric coefficient: 1.0

PLAT s1011 sa721 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1080 1706
type: Stoichiometry
physical entity: SDC2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1080 1705
type: Stoichiometry
physical entity: LPL
stoichiometric coefficient: 1.0

some protein s3788 sa2698 STOICHIOMETRY ID
type: Stoichiometry
physical entity: some protein
stoichiometric coefficient: 2.0

APP s2724 sa2196 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

Bile acids s1110 sa814 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Bile acids
stoichiometric coefficient: 1.0

CHRFAM7A
type: Protein
feature: CHRFAM7A CHRFAM7A s770 sa2229 Active
cellular location: neuron c1

APP s474 sa175 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

glutamate
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1272 2014
type: Stoichiometry
physical entity: MAC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1272 2013
type: Stoichiometry
physical entity: some protein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re512 838
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re512 839
type: Stoichiometry
physical entity: IL1B s1310 sa1115
stoichiometric coefficient: 1.0

MMP2 s3081 sa2430 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MMP2
stoichiometric coefficient: 1.0

C7
type: Protein
cellular location: default

LOO
type: SmallMolecule
cellular location: neuron c1

G2
type: Pathway

STOICHIOMETRY ID s3300 csa62
type: Stoichiometry
physical entity: TCF LEF1 CTNNB1 s3300 csa62
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB1_40-RIGHT__Oligomeric_AmyloidB-_re5
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 2
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 1
conversion direction: LEFT_TO_RIGHT
left: AmyloidB1-40
interaction type: KNOWN_TRANSITION_OMITTED
right: Oligomeric AmyloidB
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re868 1418
type: Stoichiometry
physical entity: GDI
stoichiometric coefficient: 1.0

ATP s193 sa299 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP s193 sa299
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re868 1419
type: Stoichiometry
physical entity: GTPase s2864 sa2269
stoichiometric coefficient: 1.0

PDE5A s1256 sa923 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PDE5A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re868 1417
type: Stoichiometry
physical entity: GTPase-GDI
stoichiometric coefficient: 1.0

GTP
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re161 250
type: Stoichiometry
physical entity: TP53
stoichiometric coefficient: 1.0

Fru6P s3900 sa2818 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Fru6P
stoichiometric coefficient: 1.0

C7 s361 sa9 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C7
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__APPBP1-_UBA3-RIGHT__UBA3_APPBP1-_re261
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re261 383
participant stoichiometry: PARTICIPANT STOICHIOMETRY re261 384
participant stoichiometry: PARTICIPANT STOICHIOMETRY re261 385
conversion direction: LEFT_TO_RIGHT
left: UBA3
left: APPBP1
interaction type: HETERODIMER_ASSOCIATION
right: UBA3 APPBP1 s3350 csa64
spontaneous: true
xref: HETERODIMER ASSOCIATION

STXBP1
type: Protein
feature: STXBP1 STXBP1 s2746 sa2211 Active
cellular location: neuron c1

NUDT6 s3061 sa2416 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NUDT6
stoichiometric coefficient: 1.0

IL1
type: DnaRegion
cellular location: neuron c1

Unknown receptor s2642 sa15 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Unknown receptor
stoichiometric coefficient: 4.0

STOICHIOMETRY ID s3222 csa9
type: Stoichiometry
physical entity: CDK5-IL12A
stoichiometric coefficient: 1.0

Na+
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1158 1804
type: Stoichiometry
physical entity: P2X7-ATP
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3307 csa268
type: Stoichiometry
physical entity: Oligomeric AmyloidB-HSD17B10
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1158 1803
type: Stoichiometry
physical entity: ATP s3122 sa2127
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1158 1802
type: Stoichiometry
physical entity: P2X7 s3608 sa2511
stoichiometric coefficient: 1.0

re46 s1132 sa832 88
type: Control
xref: UNKNOWN INHIBITION
control type: INHIBITION
controller: BF5-1

N2 s1120 sa818 STOICHIOMETRY ID
type: Stoichiometry
physical entity: N2
stoichiometric coefficient: 1.0

CASP1 s1892 sa1415 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 1.0

NICD s33 sa2040 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 5.0

GNAQ
type: Protein
cellular location: neuron c1

Oligomeric AmyloidB s2980 sa2346 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

STATE_TRANSITION_LEFT__IRS-RIGHT__IRS-_re827
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re827 1331
participant stoichiometry: PARTICIPANT STOICHIOMETRY re827 1330
conversion direction: LEFT_TO_RIGHT
left: IRS
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IRS
xref: STATE TRANSITION

WNT1
type: Protein
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__PPARG_RXR_unkown_PPARG_ligand-RIGHT__AmyloidB_clearance-_re787
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: AmyloidB clearance
controller: PPARG-RXR-unkown PPARG ligand

TLR
type: Protein

Unknown CASP s104 sa215 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Unknown CASP s104 sa215
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AmyloidB-RIGHT__AmyloidB_deposit-_re1223
type: Control
xref: STATE TRANSITION
controlled: AmyloidB deposit
controller: AmyloidB

phospholipase C
type: Protein
cellular location: microglia c4

TRANSLATION_LEFT__APOE-RIGHT__APOE-_re444
type: TemplateReaction
participant: APOE
product: APOE
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

DCTN5 s142 sa328 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DCTN5
stoichiometric coefficient: 1.0

NFKB responsive genes
type: RnaRegion
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re480 785
type: Stoichiometry
physical entity: sulfite s1346 sa1010
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re480 786
type: Stoichiometry
physical entity: thiosulfate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re480 787
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

COX s2814 sa2254 STOICHIOMETRY ID
type: Stoichiometry
physical entity: COX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re480 784
type: Stoichiometry
physical entity: 3-mercaptopyruvate
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB1_42-RIGHT__ADDLs-_re1048
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1048 1654
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1048 1653
conversion direction: LEFT_TO_RIGHT
left: AmyloidB1-42
interaction type: KNOWN_TRANSITION_OMITTED
right: ADDLs s1920 sa1442
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re1080 1710
type: Stoichiometry
physical entity: APOE-SDC2-LIPC-LPL-Lipoprotein remnant
stoichiometric coefficient: 1.0

K+
type: SmallMolecule
cellular location: postsynaptic density c12

F2A-isoprostanes
type: SmallMolecule
cellular location: neuron c1

TRANSCRIPTION_LEFT__NFKB_responsive_genes-RIGHT__NFKB_responsive_genes-_re656
type: TemplateReaction
participant: NFKB responsive genes
product: NFKB responsive genes
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

HETERODIMER_ASSOCIATION_LEFT__TLRs-_DAMPs-RIGHT__TLRs_DAMPs-_re1245
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1245 1975
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1245 1976
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1245 1977
conversion direction: LEFT_TO_RIGHT
left: DAMPs
left: TLRs
interaction type: HETERODIMER_ASSOCIATION
right: TLRs DAMPs s3739 csa305
spontaneous: true
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__ATF6-RIGHT__ATF6-_re65
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 112
conversion direction: LEFT_TO_RIGHT
left: ATF6 s133 sa115
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ATF6 s133 sa116
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re80 150
type: Stoichiometry
physical entity: CCNE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re128 198
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re128 199
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PPARA s3044 sa2391 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARA
stoichiometric coefficient: 1.0

MPM-2
type: Protein
cellular location: neuron c1

Phospho-N-acetylglucosamine mutase
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re267 395
type: Stoichiometry
physical entity: UBE2M-NEDD8-E3 ubiquitin ligase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re267 396
type: Stoichiometry
physical entity: UBE2-UB
stoichiometric coefficient: 1.0

acetyl-CoA
type: SmallMolecule
cellular location: mitochondria c7

PARTICIPANT STOICHIOMETRY re1269 2009
type: Stoichiometry
physical entity: NALP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1269 2008
type: Stoichiometry
physical entity: NALP1
stoichiometric coefficient: 1.0

IL4 s3668 sa2582 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL4
stoichiometric coefficient: 1.0

AICD
type: Protein
cellular location: neuron c1

oxidative stress
type: SmallMolecule
cellular location: default

HETERODIMER_ASSOCIATION_LEFT__NOTCH_ectodomain-_Delta-RIGHT__NOTCH_Delta-_re301
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re301 463
participant stoichiometry: PARTICIPANT STOICHIOMETRY re301 462
participant stoichiometry: PARTICIPANT STOICHIOMETRY re301 461
conversion direction: LEFT_TO_RIGHT
left: NOTCH ectodomain
left: Delta
interaction type: HETERODIMER_ASSOCIATION
right: NOTCH Delta s3371 csa91
spontaneous: true
xref: HETERODIMER ASSOCIATION

IL6
type: Protein
cellular location: microglia c4

HETERODIMER_ASSOCIATION_LEFT__P2X7-_ATP-RIGHT__P2X7_ATP-_re1158
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1158 1804
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1158 1803
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1158 1802
conversion direction: LEFT_TO_RIGHT
left: ATP s3122 sa2127
left: P2X7 s3608 sa2511
interaction type: HETERODIMER_ASSOCIATION
right: P2X7-ATP
spontaneous: true
xref: HETERODIMER ASSOCIATION

NTF3 s2297 sa1790 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTF3
stoichiometric coefficient: 1.0

glial cell c29
type: CellularLocationVocabulary
comment: _glial_cell

LRP s3867 sa2786 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP s3867 sa2786
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re267 397
type: Stoichiometry
physical entity: UBE2M-ROC1-UBE2-UB-NEDD8-CUL-SKP1-FBXO
stoichiometric coefficient: 1.0

NFKB s3632 sa2537 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKB
stoichiometric coefficient: 2.0

GSSG
type: SmallMolecule
cellular location: neuron c1

ITPR s129 sa108 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ITPR s129 sa108
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__estrogen-RIGHT__TCA_cycle-_re999
type: Control
xref: STATE TRANSITION
controlled: TCA cycle
controller: estrogen

CAPN2
type: Protein
feature: CAPN2 CAPN2 s2415 sa1894 Active
cellular location: endoplasmic reticulum ER c5

GLUT1
type: Protein
feature: GLUT1 GLUT1 s3905 sa2823 Active
cellular location: neuron c1

TF
type: Protein
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__create_AB_channel-RIGHT__AB_channel-_re1265
type: Interaction
participant: AB channel s3782 sa2688
participant: create AB channel
xref: KNOWN TRANSITION OMITTED

RAGE-S100/calgranulin
type: Complex
component: RAGE
component: S100/calgranulin
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re358 581
type: Stoichiometry
physical entity: PRNP s507 sa185
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re358 582
type: Stoichiometry
physical entity: SolublePRNP
stoichiometric coefficient: 1.0

TUB s930 sa649 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TUB
stoichiometric coefficient: 1.0

PRKG1
type: Protein
feature: PRKG1 PRKG1 s3540 sa935 Active

CSNK1A1
type: Protein

PARTICIPANT STOICHIOMETRY re1094 1730
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

CALM
type: Protein
cellular location: postsynaptic density c12

IL1B s3644 sa2554 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1094 1731
type: Stoichiometry
physical entity: Ca2 PLUS s3054 sa2401
stoichiometric coefficient: 1.0

PRKG1 s3540 sa935 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRKG1
stoichiometric coefficient: 1.0

PAMPs
type: Protein
cellular location: default

Insulin receptor
type: Protein

PARTICIPANT STOICHIOMETRY re80 149
type: Stoichiometry
physical entity: CCNE
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NO-RIGHT__NO-_re1251
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1251 1985
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1251 1984
conversion direction: LEFT_TO_RIGHT
left: NO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NO
xref: STATE TRANSITION

TLR4 s3591 sa2497 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 5.0

MAP2K7 s1909 sa1431 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP2K7
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__ICAM1-RIGHT__ICAM1-_re565
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re565 955
participant stoichiometry: PARTICIPANT STOICHIOMETRY re565 956
conversion direction: LEFT_TO_RIGHT
left: ICAM1 s1622 sa1246
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ICAM1 s1622 sa1246
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re1068 1681
type: Stoichiometry
physical entity: CAPN2-mutant PSEN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1068 1680
type: Stoichiometry
physical entity: mutant PSEN
stoichiometric coefficient: 1.0

K+
type: SmallMolecule
cellular location: neuron c1

MME
type: Protein
cellular location: default

CASP12 s67 sa121 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP12
stoichiometric coefficient: 1.0

APBB1 s413 sa368 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APBB1
stoichiometric coefficient: 7.0

ATG7
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1068 1679
type: Stoichiometry
physical entity: CAPN2
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__paired_helical_filaments_PHFs_-RIGHT__Neurofibrillary_tangles_NFTs_-_re45
type: Interaction
participant: paired helical filaments(PHFs)
participant: Neurofibrillary tangles(NFTs)
xref: KNOWN TRANSITION OMITTED

MAP2K6
type: Protein
feature: MAP2K6 MAP2K6 s1805 sa1343 rs1
feature: MAP2K6 MAP2K6 s1805 sa1343 Active
cellular location: MAPK cascade c6

PARTICIPANT STOICHIOMETRY re1290 2039
type: Stoichiometry
physical entity: 17S HpDHA s3825 sa2734
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1290 2038
type: Stoichiometry
physical entity: DHA
stoichiometric coefficient: 1.0

some ions s3783 sa2689 STOICHIOMETRY ID
type: Stoichiometry
physical entity: some ions
stoichiometric coefficient: 2.0

NTRK3
type: Protein
feature: NTRK3 NTRK3 s3562 sa1799 Active

IL6 s2249 sa1750 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

re40 s3261 csa58 74
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__MAPT_-RIGHT__MAPT-_re40
control type: INHIBITION
controller: APC-AXIN-GSK3B-CTNNB1

LRP5 6 s1701 sa473 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP5/6
stoichiometric coefficient: 2.0

A2M s1557 sa1200 STOICHIOMETRY ID
type: Stoichiometry
physical entity: A2M
stoichiometric coefficient: 1.0

CTNNB1 s766 sa478 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

metal ligand
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re228 333
type: Stoichiometry
physical entity: ATP s193 sa299
stoichiometric coefficient: 1.0

UBE2M s832 sa509 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UBE2M
stoichiometric coefficient: 4.0

PARTICIPANT STOICHIOMETRY re370 610
type: Stoichiometry
physical entity: AmyloidB s1136 sa89
stoichiometric coefficient: 10.0

ACHE s2828 sa2262 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACHE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re228 334
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re370 611
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1205 1895
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__AmyloidB1_42-RIGHT__Cell_Death-_re368
type: Control
xref: UNKNOWN TRANSITION
controlled: Cell Death s119 sa77
controller: AmyloidB1-42

oxidative stress s1780 sa1315 STOICHIOMETRY ID
type: Stoichiometry
physical entity: oxidative stress s1780 sa1315
stoichiometric coefficient: 1.0

AmyloidB
type: Protein
cellular location: neuron c1

S100 calgranulin s3802 sa2714 STOICHIOMETRY ID
type: Stoichiometry
physical entity: S100/calgranulin
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__NO-_re1113
type: Interaction
participant: NO
participant: Microglia Activation
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re1111 1744
type: Stoichiometry
physical entity: AGER
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1111 1745
type: Stoichiometry
physical entity: AGER-AmyloidB fibril
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1205 1896
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__MMP-RIGHT__MMP-_re499
type: TemplateReaction
participant: MMP
product: MMP
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re1084 1718
type: Stoichiometry
physical entity: SDC2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1084 1719
type: Stoichiometry
physical entity: APOE Lipoprotein remnant s3361 csa166
stoichiometric coefficient: 1.0

TNFRSF1A s2237 sa63 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFRSF1A s2237 sa63
stoichiometric coefficient: 1.0

ALB
type: Protein

PARTICIPANT STOICHIOMETRY re779 1251
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re779 1252
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1227 1943
type: Stoichiometry
physical entity: IRF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re905 1500
type: Stoichiometry
physical entity: TF-Fe
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1227 1942
type: Stoichiometry
physical entity: IRF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re905 1501
type: Stoichiometry
physical entity: TF Fe s3286 csa246
stoichiometric coefficient: 1.0

CREB s3844 sa2754 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1111 1743
type: Stoichiometry
physical entity: AmyloidB fibril s2665 sa2153
stoichiometric coefficient: 1.0

SMPD2
type: Protein
feature: SMPD2 SMPD2 s1511 sa1156 Active
cellular location: Lysosome c19

release free radicals
type: Pathway

HSPA5 s2478 sa1941 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSPA5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1084 1720
type: Stoichiometry
physical entity: APOE-SDC2-Lipoprotein remnant
stoichiometric coefficient: 1.0

iNOS s3641 sa2547 STOICHIOMETRY ID
type: Stoichiometry
physical entity: iNOS
stoichiometric coefficient: 1.0

Inflammatory stimulus for Normal Neuron
type: Pathway

CALM
type: Protein

LRP1-APOE-Lipoprotein remnant
type: Complex
component: Lipoprotein remnant
component: LRP1
component: APOE s470 sa315
cellular location: sinusoid c28

STATE_TRANSITION_LEFT__ATP2-RIGHT__ATP2-_re930
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re930 1546
participant stoichiometry: PARTICIPANT STOICHIOMETRY re930 1547
conversion direction: LEFT_TO_RIGHT
left: ATP2 s3524 sa2125
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ATP2 s3524 sa2126
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1078 1704
type: Stoichiometry
physical entity: LOO
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__WNT-RIGHT__WNT-_re709
type: TemplateReaction
participant: WNT
participant: WNT s2065 sa1583
product: WNT s2065 sa1583
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

PARTICIPANT STOICHIOMETRY re1078 1703
type: Stoichiometry
physical entity: LO
stoichiometric coefficient: 1.0

ACh-CHRM
type: Complex
component: CHRM
component: ACh s1028 sa735
cellular location: neuron c1

RYR3
type: Protein
feature: RYR3 RYR3 s3145 sa84 Active
cellular location: endoplasmic reticulum ER c5

VLDR s3600 sa2504 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VLDR s3600 sa2504
stoichiometric coefficient: 1.0

AKT1 s2927 sa2301 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

PRNP-Oligomeric AmyloidB
type: Complex
component: PRNP
component: Oligomeric AmyloidB
cellular location: neuron c1

MAP2K
type: Protein
feature: MAP2K MAP2K s2352 sa1832 Active
cellular location: MAPK cascade c6

STATE_TRANSITION_LEFT__LO-RIGHT__LOO-_re1078
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1078 1704
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1078 1703
conversion direction: LEFT_TO_RIGHT
left: LO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: LOO
xref: STATE TRANSITION

AmyloidB
type: Protein
cellular location: microglia c4

not written
type: PhysicalEntity
cellular location: default

SHC1
type: Protein
cellular location: neuron c1

gro s1753 sa1291 STOICHIOMETRY ID
type: Stoichiometry
physical entity: gro s1753 sa1291
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3200 csa112
type: Stoichiometry
physical entity: glutamate-GRIN-Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1048 1654
type: Stoichiometry
physical entity: ADDLs s1920 sa1442
stoichiometric coefficient: 1.0

IL6
type: Protein
feature: IL6 IL6 s2249 sa1750 Active
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re1048 1653
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 1.0

lipoxin A4
type: SmallMolecule
cellular location: microglia c4

STOICHIOMETRY ID s3246 csa151
type: Stoichiometry
physical entity: AGER-AmyloidB
stoichiometric coefficient: 2.0

UB-Unknown
type: Complex
component: unknown
component: UB s1716 sa574
cellular location: neuron c1

STATE_TRANSITION_LEFT__AP1-RIGHT__AP1-_re1171
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1171 1835
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1171 1836
conversion direction: LEFT_TO_RIGHT
left: AP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: AP1
xref: STATE TRANSITION

L-Cit
type: SmallMolecule
cellular location: postsynaptic density c12

GPCR homolog
type: Protein
feature: GPCR homolog GPCR homolog s315 sa72 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re150 234
type: Stoichiometry
physical entity: cholesterol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re150 235
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re150 236
type: Stoichiometry
physical entity: APOE-cholesterol
stoichiometric coefficient: 1.0

MAP3K9 10 11 s2882 sa1418 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP3K9 10 11 s2882 sa1418
stoichiometric coefficient: 1.0

C5B
type: Protein
cellular location: default

PCBP2
type: Protein
cellular location: neuron c1

FYN s3455 sa1524 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FYN s3455 sa1524
stoichiometric coefficient: 2.0

STOICHIOMETRY ID s796 csa66
type: Stoichiometry
physical entity: E3 ubiquitin-ligase
stoichiometric coefficient: 1.0

ADAM10 s975 sa687 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADAM10 s975 sa687
stoichiometric coefficient: 1.0

GGPP
type: SmallMolecule

NADH s108 sa267 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Senile_plaque-RIGHT__Microglia_Activation-_re9
type: Interaction
participant: Microglia Activation
participant: Senile plaque
xref: KNOWN TRANSITION OMITTED

HETERODIMER_ASSOCIATION_LEFT__GRIN_Mg2_PLUS_-_glutamate-RIGHT__glutamate_GRIN_Mg2_PLUS_-_re670
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re670 1099
participant stoichiometry: PARTICIPANT STOICHIOMETRY re670 1098
participant stoichiometry: PARTICIPANT STOICHIOMETRY re670 1097
conversion direction: LEFT_TO_RIGHT
left: GRIN-Mg2+
left: glutamate
interaction type: HETERODIMER_ASSOCIATION
right: glutamate-GRIN-Mg2+
spontaneous: true
xref: HETERODIMER ASSOCIATION

CASP6 s93 sa216 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP6
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB1_42-RIGHT__neuro_toxicity-_re645
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: neuro toxicity s1922 sa1445
controller: AmyloidB1 42 s1280 sa944

IGF1R
type: Protein
feature: IGF1R IGF1R s3106 sa1605 Active
cellular location: neuron c1

DMAPP
type: SmallMolecule
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__DAB1-_APP-RIGHT__APP_DAB1-_re977
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re977 1606
participant stoichiometry: PARTICIPANT STOICHIOMETRY re977 1605
participant stoichiometry: PARTICIPANT STOICHIOMETRY re977 1604
conversion direction: LEFT_TO_RIGHT
left: DAB1
left: APP
interaction type: HETERODIMER_ASSOCIATION
right: APP DAB1 s3292 csa258
spontaneous: true
xref: HETERODIMER ASSOCIATION

APBA1 s2851 sa2267 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APBA1
stoichiometric coefficient: 1.0

BID s43 sa27 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BID
stoichiometric coefficient: 1.0

MMP
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__LDLR-_AmyloidB1_42_APOE-RIGHT__LDLR_AmyloiB1_42_APOE-_re132
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re132 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY re132 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY re132 205
conversion direction: LEFT_TO_RIGHT
left: LDLR
left: AmyloidB1-42-APOE
interaction type: HETERODIMER_ASSOCIATION
right: LDLR AmyloiB1 42 APOE s3329 csa25
spontaneous: true
xref: HETERODIMER ASSOCIATION

ATG5
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re38 65
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 64
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

IRS1 s3881 sa2799 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

peroxynitrite ONOO s162 sa100 STOICHIOMETRY ID
type: Stoichiometry
physical entity: peroxynitrite (ONOO-)
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__TNFB-_re1116
type: Interaction
participant: Microglia Activation
participant: TNFB s3060 sa2414
xref: KNOWN TRANSITION OMITTED

STATE_TRANSITION_LEFT__Farnesyl_PP-RIGHT__Ubiquinone-_re1062
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1062 1671
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1062 1672
conversion direction: LEFT_TO_RIGHT
left: Farnesyl PP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Ubiquinone
xref: STATE TRANSITION

Oxydosqualene s1107 sa811 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Oxydosqualene
stoichiometric coefficient: 1.0

50kDa fragment
type: Protein
cellular location: neuron c1

NFKB1 s605 sa2355 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKB1 s605 sa2355
stoichiometric coefficient: 2.0

AB-RAGE
type: Complex
component: RAGE
component: Oligomeric AmyloidB
cellular location: default

PARTICIPANT STOICHIOMETRY re364 592
type: Stoichiometry
physical entity: Met sulfide radical cation
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1186 1871
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

PEBP1 s2148 sa1658 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PEBP1
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re364 593
type: Stoichiometry
physical entity: Met SO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1186 1872
type: Stoichiometry
physical entity: NO s159 sa97
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1316 2091
type: Stoichiometry
physical entity: NR1 NR2BR s3854 sa2773
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1316 2092
type: Stoichiometry
physical entity: NR1 NR2BR s3854 sa2774
stoichiometric coefficient: 1.0

GABARAPL2-ATG7
type: Complex
component: ATG7
component: GABARAPL2
cellular location: neuron c1

C3A s1293 sa949 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C3A s1293 sa949
stoichiometric coefficient: 2.0

sLRP-AmyloidB
type: Complex
component: AmyloidB
component: sLRP s1568 sa1207
cellular location: Blood c15

CTNNB1 s323 sa467 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

GABARAPL2
type: Protein
cellular location: neuron c1

ZAP70
type: Protein
cellular location: neuron c1

CSHL1
type: Protein

CASP8
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re395 653
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

ROS s1584 sa1219 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re395 652
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

SPHK1 s2344 sa1822 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SPHK1 s2344 sa1822
stoichiometric coefficient: 1.0

NMDAR
type: Protein
feature: NMDAR NMDAR s3852 sa2772 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re70 128
type: Stoichiometry
physical entity: CASP3 s68 sa124
stoichiometric coefficient: 1.0

Fe2 PLUS s52 sa53 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Fe2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re70 129
type: Stoichiometry
physical entity: CASP3 s68 sa123
stoichiometric coefficient: 1.0

HRK s1905 sa1427 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HRK
stoichiometric coefficient: 1.0

ACh s1025 sa734 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

SNX
type: Protein

NAD+
type: SmallMolecule
cellular location: mitochondria c7

CASP8
type: Protein
feature: CASP8 CASP8 s55 sa66 Active
cellular location: neuron c1

STATE_TRANSITION_LEFT__DAG_IP3-RIGHT__DAG-_re592
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re592 985
participant stoichiometry: PARTICIPANT STOICHIOMETRY re592 986
conversion direction: LEFT_TO_RIGHT
left: DAG-IP3
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: DAG
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re483 794
type: Stoichiometry
physical entity: sulfate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re483 793
type: Stoichiometry
physical entity: sulfite s1346 sa1010
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re483 792
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

NMDAR
type: Protein
cellular location: neuron c1

MAP2K
type: Protein
cellular location: MAPK cascade c6

AmyloidB1-40
type: Protein
cellular location: Lipid raft c32

KNOWN_TRANSITION_OMITTED_LEFT__CEX1-RIGHT__Inflammatory_signaling-_re1301
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammatory signaling
controller: CEX1

STATE_TRANSITION_LEFT__BCL2L1-RIGHT__BCL2L1-_re635
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re635 1069
participant stoichiometry: PARTICIPANT STOICHIOMETRY re635 1068
conversion direction: LEFT_TO_RIGHT
left: BCL2L1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: BCL2L1
xref: STATE TRANSITION

sAPPB s3938 sa2856 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sAPPB
stoichiometric coefficient: 1.0

some protein
type: PhysicalEntity
cellular location: neuron c1

APP s3104 sa1206 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__G2-RIGHT__G2_M_checkpoint-_re286
type: Interaction
participant: G2
participant: G2/M checkpoint
xref: KNOWN TRANSITION OMITTED

NOTCH ectodomain s2957 sa685 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NOTCH ectodomain
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__TNF-RIGHT__TNF-_re564
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re564 954
participant stoichiometry: PARTICIPANT STOICHIOMETRY re564 953
conversion direction: LEFT_TO_RIGHT
left: TNF
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNF
xref: STATE TRANSITION

TF
type: Protein

5ADHP s2823 sa2258 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 5ADHP
stoichiometric coefficient: 1.0

IGF1R s3106 sa1605 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IGF1R
stoichiometric coefficient: 1.0

re861 s2388 sa1944 1402
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__PGGT1B-RIGHT__PGGT1B-_re861
control type: INHIBITION
controller: GGTI

PARTICIPANT STOICHIOMETRY re534 897
type: Stoichiometry
physical entity: Tyr
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re534 898
type: Stoichiometry
physical entity: DA
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3215 csa117
type: Stoichiometry
physical entity: ADCY10-CALM-Ca2+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__glucose-RIGHT__Glc6P-_re1333
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1333 2141
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1333 2140
conversion direction: LEFT_TO_RIGHT
left: glucose
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Glc6P
xref: STATE TRANSITION

SCAR
type: Protein
cellular location: microglia c4

Brain c26
type: CellularLocationVocabulary
comment: _Brain

KNOWN_TRANSITION_OMITTED_LEFT__AICD-RIGHT__Modulation_of_gene_expression_-_re31
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Modulation of gene expression
controller: AICD

ADAM s1113 sa816 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADAM
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3253 csa155
type: Stoichiometry
physical entity: DKK1-KREMEN2-LRP5/6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re328 507
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re328 506
type: Stoichiometry
physical entity: ALLOP s2869 sa2274
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re328 509
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re328 508
type: Stoichiometry
physical entity: 5ADHP
stoichiometric coefficient: 1.0

CBS s1373 sa1041 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CBS
stoichiometric coefficient: 1.0

L Cys s1341 sa1005 STOICHIOMETRY ID
type: Stoichiometry
physical entity: L-Cys
stoichiometric coefficient: 1.0

MAPK1 3 s197 sa126 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re272 403
type: Stoichiometry
physical entity: UBA1 s898 sa615
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re167 262
type: Stoichiometry
physical entity: Unknown CASP s104 sa218
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re272 404
type: Stoichiometry
physical entity: UBE2-UB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re167 261
type: Stoichiometry
physical entity: Unknown CASP s104 sa215
stoichiometric coefficient: 1.0

ATP2 s3524 sa2126 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP2 s3524 sa2126
stoichiometric coefficient: 1.0

Acetate
type: SmallMolecule
cellular location: neuron c1

DHA s3823 sa2732 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DHA
stoichiometric coefficient: 2.0

NFKBI
type: Protein
feature: NFKBI NFKBI s2082 sa1457 Active
cellular location: neuron c1

APPBP1 s2807 sa2246 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APPBP1
stoichiometric coefficient: 1.0

LRP1
type: Protein
feature: LRP1 LRP1 s3389 sa2334 Active

PARTICIPANT STOICHIOMETRY re624 1048
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 1.0

PSPHL
type: Protein

s75 s75 sa62 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s75 s75 sa62
stoichiometric coefficient: 1.0

FTH s2633 sa2094 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FTH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re272 402
type: Stoichiometry
physical entity: UBE2 s894 sa618
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re272 401
type: Stoichiometry
physical entity: UBA1-UB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re624 1049
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 1.0

PEBP1 s2139 sa1653 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PEBP1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AKT1-RIGHT__AKT1-_re718
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re718 1156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re718 1157
conversion direction: LEFT_TO_RIGHT
left: AKT1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: AKT1
xref: STATE TRANSITION

RPS6KB
type: Protein
cellular location: neuron c1

PEBP1
type: Protein

KNOWN_TRANSITION_OMITTED_LEFT__Oligomeric_AmyloidB-RIGHT__Neuro_toxicity-_re129
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Neuro-toxicity
controller: Oligomeric AmyloidB

CLU
type: Protein
cellular location: Blood c15

TRANSPORT_LEFT__vesicle_transport-RIGHT__APP-_re538
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re538 909
participant stoichiometry: PARTICIPANT STOICHIOMETRY re538 908
conversion direction: LEFT_TO_RIGHT
left: vesicle transport s1537 csa145
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: APP
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re231 337
type: Stoichiometry
physical entity: NCOA-RXR-RARA-ATRA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re231 336
type: Stoichiometry
physical entity: ATRA s721 sa303
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re231 335
type: Stoichiometry
physical entity: NCOR1-RXR-RARA
stoichiometric coefficient: 1.0

FOXO s3457 sa1852 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

C1Q s342 sa306 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C1Q
stoichiometric coefficient: 2.0

TIMP1
type: Protein
cellular location: default

AmyloidB1-42
type: Protein
cellular location: default

NTF s2657 sa2117 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTF
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__PRKG1-_cGMP-RIGHT__PRKG1_cGMP-_re419
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re419 699
participant stoichiometry: PARTICIPANT STOICHIOMETRY re419 697
participant stoichiometry: PARTICIPANT STOICHIOMETRY re419 698
conversion direction: LEFT_TO_RIGHT
left: cGMP
left: PRKG1
interaction type: HETERODIMER_ASSOCIATION
right: PRKG1-cGMP
spontaneous: true
xref: HETERODIMER ASSOCIATION

s3841
type: PhysicalEntity
cellular location: neuron c1

metal ligand s1398 sa1063 STOICHIOMETRY ID
type: Stoichiometry
physical entity: metal ligand
stoichiometric coefficient: 1.0

CASP1
type: Protein
cellular location: microglia c4

NOTCH
type: Protein

CASP2
type: Protein
feature: CASP2 CASP2 s1761 sa2327 Active
cellular location: neuron c1

IKBK
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re521 865
type: Stoichiometry
physical entity: sa1156 degraded s1512 sa1157
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re521 864
type: Stoichiometry
physical entity: SMPD2
stoichiometric coefficient: 1.0

NTF3
type: Protein
cellular location: default

estrogen
type: SmallMolecule
cellular location: neuron c1

IP3
type: SmallMolecule

PARTICIPANT STOICHIOMETRY re559 942
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re559 943
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 5.0

PARTICIPANT STOICHIOMETRY re1077 1699
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1077 1698
type: Stoichiometry
physical entity: ITPR s129 sa108
stoichiometric coefficient: 1.0

DAMPs
type: Protein
cellular location: default

RPS6KB
type: Protein
feature: RPS6KB RPS6KB s2613 sa2082 Active
cellular location: neuron c1

HRK
type: DnaRegion
cellular location: MAPK cascade c6

succinate s677 sa271 STOICHIOMETRY ID
type: Stoichiometry
physical entity: succinate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SFK-RIGHT__SFK-_re720
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re720 1161
participant stoichiometry: PARTICIPANT STOICHIOMETRY re720 1160
conversion direction: LEFT_TO_RIGHT
left: SFK
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: SFK
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__AmyloidB1_42-RIGHT__fibrillary_AmyloidB-_re643
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re643 1073
participant stoichiometry: PARTICIPANT STOICHIOMETRY re643 1074
conversion direction: LEFT_TO_RIGHT
left: AmyloidB1 42 s1280 sa944
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: fibrillary AmyloidB
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re851 1387
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CCNE-RIGHT__CCNE-_re80
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re80 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY re80 149
conversion direction: LEFT_TO_RIGHT
left: CCNE
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CCNE
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re851 1388
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 4.0

STATE_TRANSITION_LEFT__MAP2K7-RIGHT__MAP2K7-_re629
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re629 1059
participant stoichiometry: PARTICIPANT STOICHIOMETRY re629 1058
conversion direction: LEFT_TO_RIGHT
left: MAP2K7
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MAP2K7
xref: STATE TRANSITION

IL1B
type: DnaRegion
cellular location: astrocyte c2

MAPK cascade c6
type: CellularLocationVocabulary
comment: _MAPK_cascade

PARTICIPANT STOICHIOMETRY re958 1571
type: Stoichiometry
physical entity: TX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re958 1570
type: Stoichiometry
physical entity: PG s78 sa157
stoichiometric coefficient: 1.0

ATG12
type: Protein

CAV1
type: Protein
cellular location: blood brain barrier BBB c22

IGF1
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re64 109
type: Stoichiometry
physical entity: EIF2AK3 s132 sa112
stoichiometric coefficient: 1.0

PSPHL s471 sa834 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PSPHL
stoichiometric coefficient: 1.0

TLR3 s3658 sa2575 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLR3 s3658 sa2575
stoichiometric coefficient: 1.0

GluR
type: Protein

NGFR-NGF
type: Complex
component: NGF s1168 sa855
component: NGFR s1169 sa859
cellular location: neuron c1

AcetoacetylCoA s1084 sa788 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AcetoacetylCoA s1084 sa788
stoichiometric coefficient: 1.0

GluR
type: Protein
cellular location: astrocyte c2

IL12A s139 sa326 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL12A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re264 394
type: Stoichiometry
physical entity: UBE2M-NEDD8-E3 ubiquitin ligase
stoichiometric coefficient: 1.0

PPARA ligands
type: SmallMolecule

PCBP2 s1468 sa1125 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PCBP2 s1468 sa1125
stoichiometric coefficient: 5.0

PARTICIPANT STOICHIOMETRY re264 392
type: Stoichiometry
physical entity: E3 ubiquitin-ligase
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__IL6-RIGHT__IL6-_re779
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re779 1251
participant stoichiometry: PARTICIPANT STOICHIOMETRY re779 1252
conversion direction: LEFT_TO_RIGHT
left: IL6
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: IL6
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re264 393
type: Stoichiometry
physical entity: UBE2M NEDD8 s3355 csa65
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re310 473
type: Stoichiometry
physical entity: KAT5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re310 474
type: Stoichiometry
physical entity: APBB1-KAT5-SET-AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re310 471
type: Stoichiometry
physical entity: SET s1001 sa711
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re492 816
type: Stoichiometry
physical entity: PTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re310 472
type: Stoichiometry
physical entity: APBB1-AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re492 817
type: Stoichiometry
physical entity: PTP s1417 sa1075
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB1_42-RIGHT__activate_microglia_inflammatory_processes-_re434
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: activate microglia inflammatory processes
controller: AmyloidB1-42

STATE_TRANSITION_LEFT__DAB1-RIGHT__DAB1-_re722
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re722 1166
participant stoichiometry: PARTICIPANT STOICHIOMETRY re722 1167
conversion direction: LEFT_TO_RIGHT
left: DAB1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: DAB1
xref: STATE TRANSITION

CREB
type: Protein
feature: CREB CREB s3844 sa2754 Active
cellular location: nucleus c3

KNOWN_TRANSITION_OMITTED_LEFT__acetyl_CoA-RIGHT__cholesterol-_geranyl_geraniol-_re146
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re146 222
participant stoichiometry: PARTICIPANT STOICHIOMETRY re146 223
participant stoichiometry: PARTICIPANT STOICHIOMETRY re146 224
conversion direction: LEFT_TO_RIGHT
left: acetyl CoA s518 sa194
interaction type: KNOWN_TRANSITION_OMITTED
right: geranyl geraniol s539 sa205
right: cholesterol
xref: KNOWN TRANSITION OMITTED

STOICHIOMETRY ID s3191 csa243
type: Stoichiometry
physical entity: NICD-CSHL1-LAG3-HAT1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CDC42-_GGPP-RIGHT__CDC42_GGPP-_re840
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re840 1363
participant stoichiometry: PARTICIPANT STOICHIOMETRY re840 1365
participant stoichiometry: PARTICIPANT STOICHIOMETRY re840 1364
conversion direction: LEFT_TO_RIGHT
left: CDC42 s2386 sa1873
left: GGPP
interaction type: HETERODIMER_ASSOCIATION
right: CDC42-GGPP
spontaneous: true
xref: HETERODIMER ASSOCIATION

IK s3464 sa2119 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IK
stoichiometric coefficient: 1.0

dedifferentiation
type: Pathway

dystrophic neurites
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__cholesterol-RIGHT__TIMP1-_re143
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re143 220
participant stoichiometry: PARTICIPANT STOICHIOMETRY re143 219
conversion direction: LEFT_TO_RIGHT
left: cholesterol
interaction type: KNOWN_TRANSITION_OMITTED
right: TIMP1
xref: KNOWN TRANSITION OMITTED

STOICHIOMETRY ID s3382 csa282
type: Stoichiometry
physical entity: NPC cholesterol s3382 csa282
stoichiometric coefficient: 1.0

HSP60 s3747 sa2662 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSP60
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re454 748
type: Stoichiometry
physical entity: HS-
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re454 749
type: Stoichiometry
physical entity: Cys-S-R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re454 746
type: Stoichiometry
physical entity: R-SH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re454 747
type: Stoichiometry
physical entity: L-Cys
stoichiometric coefficient: 1.0

Dolichol s1106 sa810 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Dolichol s1106 sa810
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re597 1004
type: Stoichiometry
physical entity: MAPT
stoichiometric coefficient: 1.0

CYP19A1 s3 sa623 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CYP19A1 s3 sa623
stoichiometric coefficient: 1.0

DAG
type: SmallMolecule
cellular location: neuron c1

RHOA s2043 sa1557 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RHOA
stoichiometric coefficient: 2.0

PTGS2
type: Protein
feature: PTGS2 PTGS2 s3466 sa2252 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re597 1003
type: Stoichiometry
physical entity: MAPT s3448 sa85
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SNCA-RIGHT__NAC-_re7
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 5
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 4
conversion direction: LEFT_TO_RIGHT
left: SNCA s50 sa51
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NAC
xref: STATE TRANSITION

PE s2210 sa1716 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PE
stoichiometric coefficient: 2.0

ALLOP
type: SmallMolecule
cellular location: astrocyte c2

IPP
type: SmallMolecule
cellular location: neuron c1

IRS1
type: Protein
feature: IRS1 IRS1 s3881 sa2799 Active
cellular location: neuron c1

PDP s658 sa255 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PDP s658 sa255
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re355 575
type: Stoichiometry
physical entity: cholesterol s87 sa190
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re355 574
type: Stoichiometry
physical entity: 7-dehydrocholesterol
stoichiometric coefficient: 1.0

CACNA1
type: Protein
cellular location: neuron c1

XBP1 s2472 sa1934 STOICHIOMETRY ID
type: Stoichiometry
physical entity: XBP1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP1-RIGHT__ATP1-_re932
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re932 1551
participant stoichiometry: PARTICIPANT STOICHIOMETRY re932 1550
conversion direction: LEFT_TO_RIGHT
left: ATP1 s3483 sa2130
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ATP1 s3483 sa2131
xref: STATE TRANSITION

Cys S R s1331 sa995 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Cys-S-R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re777 1247
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re777 1246
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__DAG_IP3-RIGHT__IP3-_re1076
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1076 1694
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1076 1695
conversion direction: LEFT_TO_RIGHT
left: DAG-IP3
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IP3
xref: STATE TRANSITION

UNKNOWN_TRANSITION_LEFT__60S-_40S-_FMR1-_PCBP2-_APP_ACO1-_PCBP1-RIGHT__ACO1-_APP_PCBP2_PCBP1_FMR1_60S_40S-_re511
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 837
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 836
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 833
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 832
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 835
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 834
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 831
participant stoichiometry: PARTICIPANT STOICHIOMETRY re511 830
conversion direction: LEFT_TO_RIGHT
left: 60S s1500 sa2328
left: PCBP2
left: 40S
left: FMR1 s1464 sa1121
left: PCBP1
left: APP ACO1 s3233 csa134
interaction type: UNKNOWN_TRANSITION
right: ACO1
right: APP PCBP2 PCBP1 FMR1 60S 40S s3232 csa135
xref: UNKNOWN TRANSITION

C99
type: Protein
cellular location: Lipid raft c32

PARTICIPANT STOICHIOMETRY re631 1061
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re631 1062
type: Stoichiometry
physical entity: JUN s2830 sa1422
stoichiometric coefficient: 1.0

CSAD s1335 sa999 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CSAD
stoichiometric coefficient: 1.0

NMDAR s3894 sa2812 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NMDAR s3894 sa2812
stoichiometric coefficient: 1.0

APAF1 s83 sa170 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APAF1
stoichiometric coefficient: 1.0

WNT
type: Protein
feature: WNT WNT s255 sa459 Active
cellular location: default

GPX s2701 sa2178 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GPX s2701 sa2178
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__sLRP_AmyloidB-RIGHT__s1577-_re547
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 926
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 925
conversion direction: LEFT_TO_RIGHT
left: sLRP-AmyloidB
interaction type: KNOWN_TRANSITION_OMITTED
right: s1577
xref: KNOWN TRANSITION OMITTED

H2O
type: SmallMolecule
cellular location: inner membrane c8

KNOWN_TRANSITION_OMITTED_LEFT__CASP7-RIGHT__apoptosis-_re169
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: CASP7 s101 sa217

re864 s2380 sa2280 1411
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__FDPS-RIGHT__FDPS-_re864
control type: INHIBITION
controller: biphosphonate s2380 sa2280

RARE target genes s2943 sa2314 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RARE target genes
stoichiometric coefficient: 1.0

ADRBK1 s2140 sa1654 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ADRBK1
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__MAPK8-RIGHT__APAF1-_re381
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re381 635
participant stoichiometry: PARTICIPANT STOICHIOMETRY re381 636
conversion direction: LEFT_TO_RIGHT
left: MAPK8
interaction type: UNKNOWN_TRANSITION
right: APAF1
xref: UNKNOWN TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__NPD1-RIGHT__ADAM10-_re1296
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1296 2051
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1296 2052
conversion direction: LEFT_TO_RIGHT
left: NPD1
interaction type: KNOWN_TRANSITION_OMITTED
right: ADAM10
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re1071 1687
type: Stoichiometry
physical entity: mutant PSEN-CIB1
stoichiometric coefficient: 1.0

GSK3B
type: Protein
feature: GSK3B GSK3B s62 sa2435 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1071 1686
type: Stoichiometry
physical entity: mutant PSEN
stoichiometric coefficient: 1.0

40S s1498 sa1149 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 40S s1498 sa1149
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re537 906
type: Stoichiometry
physical entity: vesicle transport s1537 csa145
stoichiometric coefficient: 1.0

AGEs
type: SmallMolecule
cellular location: default

PARTICIPANT STOICHIOMETRY re537 905
type: Stoichiometry
physical entity: APP s1535 sa1182
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re537 904
type: Stoichiometry
physical entity: NT s1542 sa1188
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1071 1685
type: Stoichiometry
physical entity: CIB1
stoichiometric coefficient: 1.0

TNFA s3647 sa2557 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFA
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__TTR-RIGHT__TTR-_re372
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re372 618
participant stoichiometry: PARTICIPANT STOICHIOMETRY re372 619
conversion direction: LEFT_TO_RIGHT
left: TTR
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: TTR
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re537 903
type: Stoichiometry
physical entity: UNC13A
stoichiometric coefficient: 1.0

AKT1S1 s2601 sa2060 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AKT1S1
stoichiometric coefficient: 1.0

AmyloidB1 42 s1284 sa947 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB1 42 s1284 sa947
stoichiometric coefficient: 15.0

APOE-cholesterol
type: Complex
component: cholesterol
component: APOE s470 sa315
cellular location: astrocyte c2

N APP s499 sa181 STOICHIOMETRY ID
type: Stoichiometry
physical entity: N-APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re526 875
type: Stoichiometry
physical entity: SMPD2 s1506 sa1152
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re526 874
type: Stoichiometry
physical entity: SMPD2 s1506 sa1153
stoichiometric coefficient: 1.0

Unknown transportation
type: Pathway

Trp s1529 sa1174 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Trp s1529 sa1174
stoichiometric coefficient: 1.0

POLD1
type: Protein

CUL
type: Protein

STOICHIOMETRY ID s3303 csa264
type: Stoichiometry
physical entity: APOE-AmyloidB
stoichiometric coefficient: 1.0

NADPH
type: SmallMolecule
cellular location: astrocyte c2

MAC s3787 sa2697 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAC
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__NUDT6-_re1117
type: Interaction
participant: Microglia Activation
participant: NUDT6
xref: KNOWN TRANSITION OMITTED

PRKC s1787 sa1319 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRKC s1787 sa1319
stoichiometric coefficient: 1.0

AmyloidB s2511 sa846 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

A2M s3863 sa2782 STOICHIOMETRY ID
type: Stoichiometry
physical entity: A2M
stoichiometric coefficient: 1.0

glucose
type: SmallMolecule
cellular location: neuron c1

STATE_TRANSITION_LEFT__DHA-RIGHT__DHA-_re1291
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1291 2041
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1291 2042
conversion direction: LEFT_TO_RIGHT
left: DHA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: DHA
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__TNFRSF1A_TRADD_TRAF2_RIP-_TNF-RIGHT__TNF_TNFRSF1A_TRADD_TRAF2_RIP-_re650
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re650 1082
participant stoichiometry: PARTICIPANT STOICHIOMETRY re650 1083
participant stoichiometry: PARTICIPANT STOICHIOMETRY re650 1081
conversion direction: LEFT_TO_RIGHT
left: TNF
left: TNFRSF1A TRADD TRAF2 RIP s3187 csa173
interaction type: HETERODIMER_ASSOCIATION
right: TNF-TNFRSF1A-TRADD-TRAF2-RIP
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re1220 1929
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 1.0

C99
type: Protein
cellular location: default

MIF s3469 sa2451 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MIF
stoichiometric coefficient: 1.0

KCNIP3-mutant PSEN
type: Complex
component: mutant PSEN s1437 sa1094
component: KCNIP3
cellular location: endoplasmic reticulum ER c5

MAP2K1 s2136 sa1649 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP2K1 s2136 sa1649
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__MAPK_signaling_pathway-RIGHT__neurotoxic_effect-_re1263
type: Interaction
participant: neurotoxic effect
participant: MAPK signaling pathway
xref: KNOWN TRANSITION OMITTED

FPRL1
type: Protein
cellular location: neuron c1

BACE1 s3932 sa2850 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BACE1 s3932 sa2850
stoichiometric coefficient: 1.0

Microglia Activation
type: Pathway

IL1
type: RnaRegion
cellular location: neuron c1

re596 s1787 sa1319 1000
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__APC_AXIN_GSK3B_CTNNB1-_re596
control type: INHIBITION
controller: PRKC s1787 sa1319

PARTICIPANT STOICHIOMETRY re652 1091
type: Stoichiometry
physical entity: NFKBI-NFKB1-RELA
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3352 csa77
type: Stoichiometry
physical entity: UBE2M-ROC1-UBE2-UB-NEDD8-CUL-SKP1-FBXO
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3277 csa12
type: Stoichiometry
physical entity: APP SORL1 VPS29 VPS35 SNX VPS26A s3277 csa12
stoichiometric coefficient: 1.0

FADD s1689 sa316 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 3.0

TRANSPORT_LEFT__CYC-RIGHT__CYC-_re224
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re224 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY re224 322
conversion direction: LEFT_TO_RIGHT
left: CYC s3169 sa298
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: CYC
xref: TRANSPORT

STATE_TRANSITION_LEFT__MY-RIGHT__MY-_re701
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re701 1138
participant stoichiometry: PARTICIPANT STOICHIOMETRY re701 1137
conversion direction: LEFT_TO_RIGHT
left: MY
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: MY
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__peroxynitrite__ONOO__-RIGHT__Inflammation-_re54
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammation s167 sa104
controller: peroxynitrite (ONOO-)

re932 s2356 sa1839 1548
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ATP1-RIGHT__ATP1-_re932
control type: INHIBITION
controller: hydroxyl radical s2356 sa1839

STATE_TRANSITION_LEFT__NOS-RIGHT__NOS-_re47
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 97
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 96
conversion direction: LEFT_TO_RIGHT
left: NOS
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NOS
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re383 637
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re383 638
type: Stoichiometry
physical entity: NGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re383 639
type: Stoichiometry
physical entity: NGFR AmyloidB s3199 csa111
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re914 1514
type: Stoichiometry
physical entity: FTH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re756 1215
type: Stoichiometry
physical entity: ATG7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re914 1513
type: Stoichiometry
physical entity: Fe
stoichiometric coefficient: 1.0

CASP3 s68 sa124 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP3 s68 sa124
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re756 1216
type: Stoichiometry
physical entity: ATG12
stoichiometric coefficient: 1.0

MMP s1420 sa1084 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re756 1217
type: Stoichiometry
physical entity: ATG12-ATG7
stoichiometric coefficient: 1.0

CIB1
type: Protein
cellular location: neuron c1

STOICHIOMETRY ID s3211 csa114
type: Stoichiometry
physical entity: GRIN Mg2 PLUS s3211 csa114
stoichiometric coefficient: 1.0

SMPD2 s1506 sa1153 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SMPD2 s1506 sa1153
stoichiometric coefficient: 1.0

AmyloidB
type: Protein
cellular location: blood brain barrier BBB c22

APH1 s970 sa310 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APH1
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__COX-RIGHT__COX-_re35
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 50
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 49
conversion direction: LEFT_TO_RIGHT
left: COX
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: COX
xref: STATE TRANSITION

NTF4 s2304 sa1800 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTF4 s2304 sa1800
stoichiometric coefficient: 2.0

CTNNB1-GSK3B-mutant PSEN
type: Complex
component: CTNNB1 s748 sa496
component: mutant PSEN s1437 sa1094
component: GSK3B
cellular location: endoplasmic reticulum ER c5

sAPPB
type: Protein
cellular location: Lipid raft c32

NFKB s3084 sa2441 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKB
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Microglia_Activation-RIGHT__excitotoxin-_re1114
type: Interaction
participant: Microglia Activation
participant: excitotoxin s3058 sa2410
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re914 1515
type: Stoichiometry
physical entity: FTH-ACO1-IREB2-Fe
stoichiometric coefficient: 1.0

NOTCH ectodomain
type: Protein

insulin
type: SmallMolecule
cellular location: default

Unknown TF s3467 sa2313 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Unknown TF
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__LT-RIGHT__LT-_re115
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 191
conversion direction: LEFT_TO_RIGHT
left: LT s81 sa158
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: LT s398 sa167
xref: TRANSPORT

NO
type: SmallMolecule
cellular location: presynaptic terminal c11

Oligomeric AmyloidB s511 sa387 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 5.0

APPBP1 s410 sa354 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APPBP1
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_TLR2-_re1243
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1243 1971
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1243 1972
conversion direction: LEFT_TO_RIGHT
left: TLR2
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
xref: HETERODIMER ASSOCIATION

AA
type: SmallMolecule
cellular location: neuron c1

PK s2332 sa1809 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PK s2332 sa1809
stoichiometric coefficient: 1.0

CD247
type: Protein
feature: CD247 CD247 s2465 sa2372 rs1

PARTICIPANT STOICHIOMETRY re650 1082
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

AmyloidB1 42 s330 sa25 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re650 1083
type: Stoichiometry
physical entity: TNF-TNFRSF1A-TRADD-TRAF2-RIP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re650 1081
type: Stoichiometry
physical entity: TNFRSF1A TRADD TRAF2 RIP s3187 csa173
stoichiometric coefficient: 1.0

TX
type: SmallMolecule
cellular location: neuron c1

CTNNB1 s2840 sa461 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CTNNB1 s2840 sa461
stoichiometric coefficient: 2.0

IL1B s49 sa29 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

insulin s3887 sa2807 STOICHIOMETRY ID
type: Stoichiometry
physical entity: insulin s3887 sa2807
stoichiometric coefficient: 3.0

STATE_TRANSITION_LEFT__L_Cys-RIGHT__HS_-_re485
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re485 798
participant stoichiometry: PARTICIPANT STOICHIOMETRY re485 799
conversion direction: LEFT_TO_RIGHT
left: L-Cys
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HS-
xref: STATE TRANSITION

SORL1
type: Protein

AGEs s3622 sa2524 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AGEs
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GNAQ-RIGHT__GNAQ-_re18
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 21
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 22
conversion direction: LEFT_TO_RIGHT
left: GNAQ
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GNAQ
xref: STATE TRANSITION

LDLR
type: Protein
cellular location: neuron c1

STOICHIOMETRY ID s3318 csa2
type: Stoichiometry
physical entity: AmyloidB1-42-C1Q
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__PTGS2-RIGHT__PTGS2-_re109
type: TemplateReaction
participant: PTGS2
participant: PTGS2 s395 sa155
product: PTGS2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

STOICHIOMETRY ID s3190 csa242
type: Stoichiometry
physical entity: NICD-INPP5K-CSHL1-HAT1-HDAC-NCOR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1202 1890
type: Stoichiometry
physical entity: TNFA
stoichiometric coefficient: 1.0

NFKB1-RELA
type: Complex
component: RELA
component: NFKB1 s605 sa2355
cellular location: nucleus c3

RAGE s3613 sa2514 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RAGE
stoichiometric coefficient: 7.0

STOICHIOMETRY ID s3353 csa180
type: Stoichiometry
physical entity: UBE2M-ROC1-UBE2-NEDD8-CUL-SKP1-FBXO
stoichiometric coefficient: 1.0

TCF s1705 sa491 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re64 110
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Farnesyl_PP-RIGHT__GGPP-_re1036
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1036 1646
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1036 1647
conversion direction: LEFT_TO_RIGHT
left: Farnesyl PP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GGPP
xref: STATE TRANSITION

STOICHIOMETRY ID s3204 csa193
type: Stoichiometry
physical entity: ADRBK1-PEBP1
stoichiometric coefficient: 1.0

PLA2G1B s3465 sa2170 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLA2G1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1220 1930
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

ADRBK1-PEBP1
type: Complex
component: PEBP1
component: ADRBK1 s2149 sa1660
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1202 1889
type: Stoichiometry
physical entity: TNFA s3630 sa2534
stoichiometric coefficient: 1.0

Notch site3 cleavaged protien
type: Protein
cellular location: default

JUN s2830 sa1422 STOICHIOMETRY ID
type: Stoichiometry
physical entity: JUN s2830 sa1422
stoichiometric coefficient: 1.0

TLR8
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1322 2112
type: Stoichiometry
physical entity: AGE s3873 sa2790
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1322 2113
type: Stoichiometry
physical entity: AGE-RAGE
stoichiometric coefficient: 1.0

synaptic plasticity
type: Pathway

SRA2 s3707 sa2619 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRA2
stoichiometric coefficient: 1.0

oxidase
type: Protein
cellular location: microglia c4

PSPHL
type: Protein
feature: PSPHL PSPHL s471 sa174 Active
cellular location: neuron c1

CDKN1A s74 sa138 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDKN1A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1322 2111
type: Stoichiometry
physical entity: RAGE s3872 sa2789
stoichiometric coefficient: 1.0

Squalene s1100 sa804 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Squalene s1100 sa804
stoichiometric coefficient: 1.0

folate
type: SmallMolecule
cellular location: neuron c1

H2O2
type: SmallMolecule
cellular location: default

TRANSPORT
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__cGMP-RIGHT__5'GMP-_re391
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re391 644
participant stoichiometry: PARTICIPANT STOICHIOMETRY re391 645
conversion direction: LEFT_TO_RIGHT
left: cGMP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: 5'GMP
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re975 1599
type: Stoichiometry
physical entity: APP-APBB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re975 1598
type: Stoichiometry
physical entity: ABL s2722 sa2195
stoichiometric coefficient: 1.0

NGF
type: Protein

STATE_TRANSITION_LEFT__PIK3-RIGHT__PIK3-_re277
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re277 420
participant stoichiometry: PARTICIPANT STOICHIOMETRY re277 419
conversion direction: LEFT_TO_RIGHT
left: PIK3
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PIK3
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__NCOR1_RXR_RARA-_ATRA-RIGHT__NCOA_RXR_RARA_ATRA-_re231
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re231 337
participant stoichiometry: PARTICIPANT STOICHIOMETRY re231 336
participant stoichiometry: PARTICIPANT STOICHIOMETRY re231 335
conversion direction: LEFT_TO_RIGHT
left: NCOR1-RXR-RARA
left: ATRA s721 sa303
interaction type: HETERODIMER_ASSOCIATION
right: NCOA-RXR-RARA-ATRA
spontaneous: true
xref: HETERODIMER ASSOCIATION

HETERODIMER_ASSOCIATION_LEFT__UBE2M-_NEDD8-RIGHT__UBE2M_NEDD8-_re263
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re263 390
participant stoichiometry: PARTICIPANT STOICHIOMETRY re263 391
participant stoichiometry: PARTICIPANT STOICHIOMETRY re263 389
conversion direction: LEFT_TO_RIGHT
left: NEDD8
left: UBE2M
interaction type: HETERODIMER_ASSOCIATION
right: UBE2M NEDD8 s3355 csa65
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re815 1315
type: Stoichiometry
physical entity: superoxide anion
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re815 1314
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

CASP8 s55 sa65 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP8
stoichiometric coefficient: 1.0

GUCY1 s1252 sa920 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GUCY1
stoichiometric coefficient: 1.0

PSEN
type: Protein

PARTICIPANT STOICHIOMETRY re832 1341
type: Stoichiometry
physical entity: ceramide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re832 1342
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

CLU
type: Protein
cellular location: Brain c26

24-OH-Chol
type: SmallMolecule
cellular location: neuron c1

RAF1
type: Protein

PARTICIPANT STOICHIOMETRY re448 734
type: Stoichiometry
physical entity: ACTA1 s1317 sa980
stoichiometric coefficient: 1.0

unknown PPARG ligand s2594 sa1764 STOICHIOMETRY ID
type: Stoichiometry
physical entity: unknown PPARG ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re448 735
type: Stoichiometry
physical entity: ACTA1
stoichiometric coefficient: 1.0

CHRFAM7A
type: Protein

SRI
type: Protein
cellular location: neuron c1

STATE_TRANSITION_LEFT__VEGFA-RIGHT__VEGFA-_re902
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re902 1492
participant stoichiometry: PARTICIPANT STOICHIOMETRY re902 1491
conversion direction: LEFT_TO_RIGHT
left: VEGFA
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: VEGFA
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__C3A-_C1Q_AmyloidB1_42_C3B-RIGHT__C1Q-_C3A_AmyloidB1_42-_C3B-_re428
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re428 714
participant stoichiometry: PARTICIPANT STOICHIOMETRY re428 715
participant stoichiometry: PARTICIPANT STOICHIOMETRY re428 716
participant stoichiometry: PARTICIPANT STOICHIOMETRY re428 717
participant stoichiometry: PARTICIPANT STOICHIOMETRY re428 718
conversion direction: LEFT_TO_RIGHT
left: C3A
left: C1Q-AmyloidB1-42-C3B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: C3B s3489 sa946
right: C3A-AmyloidB1-42
right: C1Q
xref: STATE TRANSITION

STOICHIOMETRY ID s3276 csa21
type: Stoichiometry
physical entity: VPS29-VPS35-SNX-VPS26A
stoichiometric coefficient: 1.0

KREMEN2
type: Protein
feature: KREMEN2 KREMEN2 s3551 sa1281 Active

Protein Oxidation
type: Pathway

SCAR s19 sa2423 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SCAR
stoichiometric coefficient: 1.0

Zn2 PLUS s3879 sa2797 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Zn2+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__sphingomyelin-RIGHT__ceramide-_re809
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re809 1302
participant stoichiometry: PARTICIPANT STOICHIOMETRY re809 1301
conversion direction: LEFT_TO_RIGHT
left: sphingomyelin
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ceramide
xref: STATE TRANSITION

GUCY1 s1182 sa918 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GUCY1
stoichiometric coefficient: 1.0

AICD s3940 sa2858 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

BTRC
type: Protein
cellular location: neuron c1

MTOR s2152 sa1669 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MTOR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re651 1088
type: Stoichiometry
physical entity: IKBK
stoichiometric coefficient: 1.0

sulfite s1346 sa1010 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sulfite s1346 sa1010
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re651 1089
type: Stoichiometry
physical entity: IKBK
stoichiometric coefficient: 1.0

fibrillary AmyloidB
type: Protein
cellular location: default

NOS
type: Protein
feature: NOS NOS s157 sa95 rs1
feature: NOS NOS s157 sa95 Active
cellular location: neuron c1

STATE_TRANSITION_LEFT__NICD-RIGHT__s49-_re886
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re886 1453
participant stoichiometry: PARTICIPANT STOICHIOMETRY re886 1454
conversion direction: LEFT_TO_RIGHT
left: NICD s972 sa682
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: s49 s2552 sa2015
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__IL6-RIGHT__IL6-_re563
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re563 951
participant stoichiometry: PARTICIPANT STOICHIOMETRY re563 950
conversion direction: LEFT_TO_RIGHT
left: IL6 s1620 sa1244
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IL6 s1620 sa1249
xref: STATE TRANSITION

LRP1-APOE
type: Complex
component: LRP1 s3604 sa2507
component: APOE s470 sa315
cellular location: microglia c4

cholesterol s533 sa391 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cholesterol
stoichiometric coefficient: 3.0

TLR4-DAMPs
type: Complex
component: TLR4
component: DAMPs s3733 sa2647
cellular location: neuron c1

ALB s2504 sa847 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ALB
stoichiometric coefficient: 2.0

TRANSCRIPTION_LEFT__BACE1-RIGHT__BACE1-_re420
type: TemplateReaction
participant: BACE1
product: BACE1
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

KNOWN_TRANSITION_OMITTED_LEFT__CD93_C1Q_AmyloidB1_42-RIGHT__Microglia_Activation-_re98
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Microglia Activation
controller: CD93-C1Q-AmyloidB1-42

PARTICIPANT STOICHIOMETRY re816 1318
type: Stoichiometry
physical entity: H2O2 s1924 sa1447
stoichiometric coefficient: 1.0

CHRM1 s2068 sa1586 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRM1 s2068 sa1586
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3320 csa220
type: Stoichiometry
physical entity: RHOA-GGPP
stoichiometric coefficient: 1.0

GSSG+HS-
type: SmallMolecule
cellular location: mitochondria c7

neurotoxic effect
type: Pathway

PARTICIPANT STOICHIOMETRY re529 888
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 1.0

LIPC s1874 sa1394 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LIPC
stoichiometric coefficient: 2.0

TRANSLATION_LEFT__EDN1-RIGHT__EDN1-_re570
type: TemplateReaction
participant: EDN1
participant: EDN1 s1642 sa1256
product: EDN1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

FDPS s1098 sa1949 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FDPS s1098 sa1949
stoichiometric coefficient: 1.0

BF5-1
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re23 38
type: Stoichiometry
physical entity: TNFRSF1A-FADD-CASP8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re529 887
type: Stoichiometry
physical entity: SAMe
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re529 886
type: Stoichiometry
physical entity: 1-Met
stoichiometric coefficient: 1.0

IL6
type: DnaRegion
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re23 37
type: Stoichiometry
physical entity: CASP8
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CDKN1A-RIGHT__CDKN1A-_re85
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re85 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY re85 154
conversion direction: LEFT_TO_RIGHT
left: CDKN1A s74 sa144
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CDKN1A
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__DR6-RIGHT__Necrosis-_re1192
type: Control
xref: STATE TRANSITION
controlled: Necrosis s3653 sa2566
controller: DR6 s3654 sa2568

Insulin receptor s3883 sa2804 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Insulin receptor
stoichiometric coefficient: 1.0

Fe s1451 sa1109 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Fe
stoichiometric coefficient: 4.0

PARTICIPANT STOICHIOMETRY re816 1317
type: Stoichiometry
physical entity: superoxide anion
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RPS6KA1-RIGHT__RPS6KA1-_re898
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re898 1479
participant stoichiometry: PARTICIPANT STOICHIOMETRY re898 1480
conversion direction: LEFT_TO_RIGHT
left: RPS6KA1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: RPS6KA1
xref: STATE TRANSITION

sAPPB s2759 sa2226 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sAPPB
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re67
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 118
conversion direction: LEFT_TO_RIGHT
left: Ca2+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Ca2+
xref: STATE TRANSITION

ACO1 s1472 sa1130 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACO1
stoichiometric coefficient: 2.0

AKT1S1
type: Protein
feature: AKT1S1 AKT1S1 s2601 sa2060 Active
cellular location: neuron c1

STATE_TRANSITION_LEFT__ATP-RIGHT__ATP-_re1185
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1185 1869
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1185 1870
conversion direction: LEFT_TO_RIGHT
left: ATP s890 sa613
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ATP s3122 sa2127
xref: STATE TRANSITION

CHRFAM7A-APC
type: Complex
component: CHRFAM7A
component: APC
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re809 1302
type: Stoichiometry
physical entity: ceramide
stoichiometric coefficient: 1.0

ROR
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re809 1301
type: Stoichiometry
physical entity: sphingomyelin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ROS-RIGHT__Necrosis-_re1190
type: Control
xref: STATE TRANSITION
controlled: Necrosis s3653 sa2566
controller: ROS

STOICHIOMETRY ID s3254 csa156
type: Stoichiometry
physical entity: FAS-CASP2
stoichiometric coefficient: 1.0

TLRs s3741 sa2656 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TLRs s3741 sa2656
stoichiometric coefficient: 2.0

recruitment of microglia
type: Pathway

taurine s1323 sa987 STOICHIOMETRY ID
type: Stoichiometry
physical entity: taurine
stoichiometric coefficient: 1.0

PPARA s3041 sa2389 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARA
stoichiometric coefficient: 1.0

NICD-INPP5K-CSHL1-HAT1-HDAC-NCOR2
type: Complex
component: HAT1
component: CSHL1
component: NICD
component: INPP5K
component: HDAC s10 sa2026
component: NCOR2
cellular location: nucleus c3

STOICHIOMETRY ID s3316 csa277
type: Stoichiometry
physical entity: GluR-glutamate
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__TLRs-RIGHT__inflammation-_re1232
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: inflammation
controller: TLRs

NO s1246 sa916 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 3.0

STATE_TRANSITION_LEFT__TNF_production-RIGHT__TNF-_re1093
type: Interaction
participant: TNF production s3053 sa2399
participant: TNF s3052 sa2398
xref: STATE TRANSITION

STOICHIOMETRY ID s3217 csa120
type: Stoichiometry
physical entity: GUCY1-NO
stoichiometric coefficient: 1.0

ACTA1
type: Protein
cellular location: default

ATG5 s2199 sa1704 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG5
stoichiometric coefficient: 3.0

STATE_TRANSITION_LEFT__chemotaxis-RIGHT__phagocytosis-_re1215
type: Control
xref: STATE TRANSITION
controlled: phagocytosis s3689 sa2603
controller: chemotaxis s3688 sa2602

PKC response
type: Pathway

GDI
type: Protein
feature: GDI GDI s2492 sa1960 Active

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB1_42-RIGHT__Inflammatory_stimulus_for_Normal_Neuron-_re106
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammatory stimulus for Normal Neuron
controller: AmyloidB1-42

IREB2
type: Protein
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__self_drive_danger_signals-RIGHT__DAMPs-_re1247
type: Interaction
participant: DAMPs
participant: self drive danger signals
xref: KNOWN TRANSITION OMITTED

sphingomyelin s2350 sa2444 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sphingomyelin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PDK1-RIGHT__PDK1-_re279
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re279 422
participant stoichiometry: PARTICIPANT STOICHIOMETRY re279 423
conversion direction: LEFT_TO_RIGHT
left: PDK1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PDK1 s915 sa635
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__UB-_unknown-RIGHT__UB_Unknown-_re692
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re692 1114
participant stoichiometry: PARTICIPANT STOICHIOMETRY re692 1112
participant stoichiometry: PARTICIPANT STOICHIOMETRY re692 1113
conversion direction: LEFT_TO_RIGHT
left: UB s937 sa658
left: unknown
interaction type: HETERODIMER_ASSOCIATION
right: UB-Unknown
spontaneous: true
xref: HETERODIMER ASSOCIATION

DA
type: SmallMolecule
cellular location: neuron c1

sa956 degraded s1296 sa957 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sa956_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1172 1841
type: Stoichiometry
physical entity: NFKB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1172 1840
type: Stoichiometry
physical entity: NFKB
stoichiometric coefficient: 1.0

thiosulfate
type: SmallMolecule
cellular location: mitochondria c7

PARTICIPANT STOICHIOMETRY re903 1494
type: Stoichiometry
physical entity: EIF4EBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re903 1495
type: Stoichiometry
physical entity: EIF4EBP1
stoichiometric coefficient: 1.0

SKP1 s794 sa513 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SKP1 s794 sa513
stoichiometric coefficient: 4.0

STOICHIOMETRY ID s3587 csa283
type: Stoichiometry
physical entity: TLR-AmyloidB
stoichiometric coefficient: 1.0

sphingoshine1-P
type: SmallMolecule
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__MAPT-RIGHT__MAPT-_re43
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 87
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 86
conversion direction: LEFT_TO_RIGHT
left: MAPT
interaction type: KNOWN_TRANSITION_OMITTED
right: MAPT s151 sa91
xref: KNOWN TRANSITION OMITTED

GPCR homolog s1781 sa1314 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GPCR homolog
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re460 763
type: Stoichiometry
physical entity: sulfite
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__TNFA-RIGHT__activate_microglia-_re1200
type: Control
xref: STATE TRANSITION
controlled: activate microglia s3633 sa2539
controller: TNFA s3648 sa2558

PARTICIPANT STOICHIOMETRY re460 762
type: Stoichiometry
physical entity: thiosulfate s1332 sa996
stoichiometric coefficient: 1.0

LDLR s1856 sa1392 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LDLR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re246 347
type: Stoichiometry
physical entity: DVL s2834 sa463
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re246 346
type: Stoichiometry
physical entity: DVL
stoichiometric coefficient: 1.0

RYR3 s3145 sa84 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RYR3
stoichiometric coefficient: 1.0

BH4 s1532 sa2279 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BH4
stoichiometric coefficient: 1.0

GAPDH
type: Protein

TREM1
type: Protein

APOE
type: Protein
cellular location: neuron c1

NAD+
type: SmallMolecule
cellular location: default

GABARAPL2-ATG3
type: Complex
component: ATG3 s2223 sa1724
component: GABARAPL2
cellular location: neuron c1

CASP12
type: Protein
feature: CASP12 CASP12 s67 sa121 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re793 1273
type: Stoichiometry
physical entity: NTRK2 s2293 sa1786
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re793 1274
type: Stoichiometry
physical entity: BDNF s2295 sa1788
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re793 1275
type: Stoichiometry
physical entity: BDNF-NTRK2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__IK-RIGHT__IK-_re927
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re927 1538
participant stoichiometry: PARTICIPANT STOICHIOMETRY re927 1539
conversion direction: LEFT_TO_RIGHT
left: IK
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IK
xref: STATE TRANSITION

MTOR
type: Protein
cellular location: neuron c1

cellular stress
type: Pathway

CN s3849 sa2762 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CN
stoichiometric coefficient: 1.0

5ADHP
type: SmallMolecule
cellular location: mitochondria c7

ACh s1028 sa735 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACh s1028 sa735
stoichiometric coefficient: 1.0

axonal transport
type: Pathway

HETERODIMER_ASSOCIATION_LEFT__Oligomeric_AmyloidB-_Unknown_receptor-RIGHT__Unknown_receptor_Oligomeric_AmyloicB-_re1118
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1118 1747
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1118 1748
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1118 1746
conversion direction: LEFT_TO_RIGHT
left: Oligomeric AmyloidB
left: Unknown receptor
interaction type: HETERODIMER_ASSOCIATION
right: Unknown receptor Oligomeric AmyloicB s3317 csa280
spontaneous: true
xref: HETERODIMER ASSOCIATION

LDLR-APOE-Lipoprotein remnant
type: Complex
component: LDLR
component: Lipoprotein remnant
component: APOE s470 sa315
cellular location: sinusoid c28

PARTICIPANT STOICHIOMETRY re601 1015
type: Stoichiometry
physical entity: MAP2K6
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__GRN-RIGHT__inflammatory_response-_re1073
type: Control
xref: UNKNOWN TRANSITION
controlled: inflammatory response s3026 sa2377
controller: GRN

RIPK2
type: Protein
feature: RIPK2 RIPK2 s3728 sa2642 Active
cellular location: microglia c4

STATE_TRANSITION_LEFT__APC_AXIN_GSK3B_CTNNB1-RIGHT__CTNNB1-_re248
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re248 355
participant stoichiometry: PARTICIPANT STOICHIOMETRY re248 356
conversion direction: LEFT_TO_RIGHT
left: APC-AXIN-GSK3B-CTNNB1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CTNNB1
xref: STATE TRANSITION

ATG12-ATG6
type: Complex
component: ATG5
component: ATG12
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re601 1014
type: Stoichiometry
physical entity: MAP2K6
stoichiometric coefficient: 1.0

GRI-glutamate
type: Complex
component: glutamate s1206 sa1497
component: GRI
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re18 21
type: Stoichiometry
physical entity: GNAQ
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 22
type: Stoichiometry
physical entity: GNAQ
stoichiometric coefficient: 1.0

Ca2+
type: SmallMolecule

SMPD2
type: Protein
feature: SMPD2 SMPD2 s1508 sa1155 Active
cellular location: late endosome c18

STOICHIOMETRY ID s3360 csa169
type: Stoichiometry
physical entity: LRP1-APOE-Lipoprotein remnant
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__PRIM_APEX1_POLD1_replication_origin-RIGHT__BER-_re160
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: BER s567 sa211
controller: PRIM-APEX1-POLD1-replication origin

TNF s3471 sa2453 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

Fru6P
type: SmallMolecule
cellular location: neuron c1

COX2
type: RnaRegion
cellular location: neuron c1

IL4R s3672 sa2585 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL4R
stoichiometric coefficient: 1.0

TNFA
type: Protein
cellular location: neuron c1

MTOR
type: Protein
feature: MTOR MTOR s2152 sa1669 Active
cellular location: neuron c1

TREM2 s3758 sa2669 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TREM2 s3758 sa2669
stoichiometric coefficient: 1.0

NICD
type: Protein

PARTICIPANT STOICHIOMETRY re110 175
type: Stoichiometry
physical entity: PGG2 s400 sa160
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__LRP8-_RELN-RIGHT__LRP8_RELN-_re726
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re726 1179
participant stoichiometry: PARTICIPANT STOICHIOMETRY re726 1178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re726 1177
conversion direction: LEFT_TO_RIGHT
left: RELN s2095 sa1618
left: LRP8
interaction type: HETERODIMER_ASSOCIATION
right: LRP8-RELN
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re110 174
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__PDH-RIGHT__PDH-_re206
type: TemplateReaction
participant: PDH
product: PDH
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re479 779
type: Stoichiometry
physical entity: R s1369 sa1035
stoichiometric coefficient: 1.0

K PLUS s2648 sa2107 STOICHIOMETRY ID
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re110 176
type: Stoichiometry
physical entity: unknown
stoichiometric coefficient: 1.0

Q
type: SmallMolecule
cellular location: mitochondria c7

PARTICIPANT STOICHIOMETRY re353 570
type: Stoichiometry
physical entity: Squalene s1100 sa804
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re353 571
type: Stoichiometry
physical entity: Oxydosqualene
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re828 1334
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re828 1333
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

ACTA1 s1316 sa979 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACTA1 s1316 sa979
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re479 780
type: Stoichiometry
physical entity: thiosulfate
stoichiometric coefficient: 1.0

NAC
type: PhysicalEntity
cellular location: default

STOICHIOMETRY ID s3346 csa279
type: Stoichiometry
physical entity: AGER-AmyloidB fibril
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re479 782
type: Stoichiometry
physical entity: R S s1370 sa1036
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re479 781
type: Stoichiometry
physical entity: sulfite s1346 sa1010
stoichiometric coefficient: 1.0

TNF s2765 sa2234 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

sLRP s1568 sa1207 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sLRP s1568 sa1207
stoichiometric coefficient: 1.0

PPARG s3832 sa2741 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARG
stoichiometric coefficient: 1.0

RIPK2
type: Protein
cellular location: microglia c4

NCSTN
type: Protein

PIP3 s171 sa107 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PIP3 s171 sa107
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3332 csa29
type: Stoichiometry
physical entity: NR1H-24-OH-Chol
stoichiometric coefficient: 1.0

Methylcobalamin
type: SmallMolecule
cellular location: neuron c1

MMP9 s1013 sa2432 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MMP9
stoichiometric coefficient: 1.0

PPARA
type: Protein
cellular location: microglia c4

microtubules
type: Complex
component: TUB
cellular location: neuron c1

AGER
type: Protein
cellular location: Blood c15

KNOWN_TRANSITION_OMITTED_LEFT__CASP6-RIGHT__apoptosis-_re168
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: CASP6

default
type: CellularLocationVocabulary
comment: _

GUCY1
type: Protein
feature: GUCY1 GUCY1 s1261 sa873 Active

Insulin receptor s3886 sa2806 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Insulin receptor
stoichiometric coefficient: 1.0

PRKG1 s3463 sa2104 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRKG1
stoichiometric coefficient: 1.0

NCOR1-RXR-RARA
type: Complex
component: RARA s1693 sa412
component: RXR s716 sa411
component: NCOR1
cellular location: nucleus c3

NGFR-BDNF
type: Complex
component: BDNF
component: NGFR s1178 sa858
cellular location: neuron c1

GLUT s3907 sa2826 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GLUT
stoichiometric coefficient: 1.0

CD36 s3697 sa2610 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD36
stoichiometric coefficient: 1.0

CDK1
type: Protein
cellular location: neuron c1

IL11
type: Protein
cellular location: neuron c1

HNE
type: SmallMolecule
cellular location: neuron c1

EGF-EGFR
type: Complex
component: EGFR
component: EGF s1412 sa1073
cellular location: neuron c1

CAMK2 s2053 sa1569 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CAMK2 s2053 sa1569
stoichiometric coefficient: 2.0

PLA2 s3828 sa2737 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

TTR
type: Protein

CSF c16
type: CellularLocationVocabulary
comment: _CSF

sAPPA
type: Protein
cellular location: default

AmyloidB
type: Protein
cellular location: default

AmyloidB
type: Protein
cellular location: Brain c26

BAX s1913 sa1433 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BAX s1913 sa1433
stoichiometric coefficient: 1.0

MAPK14 s1795 sa1330 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK14
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__PPARA-_PPARA_ligands-RIGHT__PPARA_ligands_PPARA-_re1085
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1085 1723
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1085 1722
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1085 1721
conversion direction: LEFT_TO_RIGHT
left: PPARA ligands
left: PPARA
interaction type: HETERODIMER_ASSOCIATION
right: PPARA ligands-PPARA
spontaneous: true
xref: HETERODIMER ASSOCIATION

SCAR
type: Protein
feature: SCAR SCAR s19 sa2423 Active

PARTICIPANT STOICHIOMETRY re255 370
type: Stoichiometry
physical entity: APC-GSK3B-AXIN-CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re255 371
type: Stoichiometry
physical entity: CTNNB1 s2840 sa461
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
cellular location: postsynaptic density c12

re854 s3025 sa2376 1395
type: Control
xref: INHIBITION
controlled: STATE TRANSITION LEFT XBP1-RIGHT XBP1- re854
control type: INHIBITION
controller: mutant PSEN

SRB1 s3661 sa2578 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRB1
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__NUDT6-RIGHT__neurotoxin-_re1109
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: neurotoxin s3062 sa2418
controller: NUDT6

PRKAA2 s3461 sa2063 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRKAA2
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3250 csa152
type: Stoichiometry
physical entity: CAV1-TJ
stoichiometric coefficient: 1.0

GDF s2487 sa1955 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GDF s2487 sa1955
stoichiometric coefficient: 1.0

TNF s3797 sa2709 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

TRANSLATION
type: RelationshipTypeVocabulary

PDH
type: RnaRegion
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re900 1485
type: Stoichiometry
physical entity: PSMD9
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re900 1484
type: Stoichiometry
physical entity: PSMD9
stoichiometric coefficient: 1.0

IDE s3675 sa2589 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IDE
stoichiometric coefficient: 1.0

GABA
type: SmallMolecule
cellular location: synaptic vesicle c14

NFAT s2437 sa1911 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFAT s2437 sa1911
stoichiometric coefficient: 1.0

AmyloidB1 40 s11 sa39 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB1-40
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__s3839-RIGHT__B94-_re1298
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1298 2055
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1298 2054
conversion direction: LEFT_TO_RIGHT
left: s3839 s3839 sa2748
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: B94 s3837 sa2746
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re202 289
type: Stoichiometry
physical entity: PGK s3488 sa250
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re202 288
type: Stoichiometry
physical entity: PGK
stoichiometric coefficient: 1.0

KREMEN2 s3551 sa1281 STOICHIOMETRY ID
type: Stoichiometry
physical entity: KREMEN2
stoichiometric coefficient: 1.0

s1594 s1594 sa1231 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s1594
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__oxyradical-RIGHT__apoptosis-_re962
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: apoptosis s63 sa102
controller: oxyradical

MAP3K s1796 sa2245 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1270 2012
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

LIN7
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1270 2011
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

TF s2621 sa2083 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TF
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__ACTA1-RIGHT__ACTA1-_re446
type: TemplateReaction
participant: ACTA1
participant: ACTA1 s1316 sa979
product: ACTA1 s1316 sa979
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

AmyloidB fibril
type: Protein

TJ
type: Protein

IFI44 s2790 sa1858 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IFI44 s2790 sa1858
stoichiometric coefficient: 1.0

MAP3K
type: Protein
feature: MAP3K MAP3K s1796 sa2245 Active
cellular location: MAPK cascade c6

PARTICIPANT STOICHIOMETRY re289 442
type: Stoichiometry
physical entity: microtubules
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__H2O2-RIGHT__Neuronal_injury-_re29
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Neuronal injury
controller: H2O2

PARTICIPANT STOICHIOMETRY re289 441
type: Stoichiometry
physical entity: TUB
stoichiometric coefficient: 1.0

SDC2 s2846 sa1405 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SDC2
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re1167 1824
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1167 1825
type: Stoichiometry
physical entity: IL1B
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__thiosulfate-RIGHT__sulfite-_re460
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re460 763
participant stoichiometry: PARTICIPANT STOICHIOMETRY re460 762
conversion direction: LEFT_TO_RIGHT
left: thiosulfate s1332 sa996
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sulfite
xref: STATE TRANSITION

KNOWN_TRANSITION_OMITTED_LEFT__Lipid_peroxidation-RIGHT__aldehydes-_re825
type: Interaction
participant: aldehydes
participant: Lipid peroxidation
xref: KNOWN TRANSITION OMITTED

LIN7
type: Protein
feature: LIN7 LIN7 s2750 sa2218 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re578 965
type: Stoichiometry
physical entity: DKK1-KREMEN2-LRP5/6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re578 964
type: Stoichiometry
physical entity: LRP5/6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re578 963
type: Stoichiometry
physical entity: DKK1 s1749 sa1283
stoichiometric coefficient: 1.0

HSP60
type: Protein
cellular location: mitochondria c7

PARTICIPANT STOICHIOMETRY re578 962
type: Stoichiometry
physical entity: KREMEN2
stoichiometric coefficient: 1.0

VHL
type: Protein
cellular location: neuron c1

IRS1 s3881 sa2802 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IRS1 s3881 sa2802
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re89 158
type: Stoichiometry
physical entity: NFKBI-NFKB1-RELA
stoichiometric coefficient: 1.0

GlcNAc1P
type: SmallMolecule
cellular location: neuron c1

STATE_TRANSITION_LEFT__L_Cys-RIGHT__3_mercaptopyruvate-_re452
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re452 744
participant stoichiometry: PARTICIPANT STOICHIOMETRY re452 743
conversion direction: LEFT_TO_RIGHT
left: L-Cys
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: 3-mercaptopyruvate
xref: STATE TRANSITION

GRIA s3525 sa2137 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GRIA
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__A2M-_LRP-RIGHT__A2MLRP-_re1319
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1319 2102
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1319 2101
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1319 2103
conversion direction: LEFT_TO_RIGHT
left: LRP
left: A2M
interaction type: HETERODIMER_ASSOCIATION
right: A2MLRP
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re89 159
type: Stoichiometry
physical entity: NFKB1 RELA s3308 csa269
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__FZD_LRP5_6_CSNK1A1-_WNT-RIGHT__FZD_WNT_LRP5_6-_CSNK1A1-_re245
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re245 342
participant stoichiometry: PARTICIPANT STOICHIOMETRY re245 343
participant stoichiometry: PARTICIPANT STOICHIOMETRY re245 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY re245 344
conversion direction: LEFT_TO_RIGHT
left: FZD LRP5 6 CSNK1A1 s3322 csa54
left: WNT
interaction type: HETERODIMER_ASSOCIATION
right: CSNK1A1
right: FZD-WNT-LRP5/6
spontaneous: true
xref: HETERODIMER ASSOCIATION

SRA2-AmyloidB
type: Complex
component: AmyloidB
component: SRA2
cellular location: microglia c4

KNOWN_TRANSITION_OMITTED_LEFT__neuronal_stem_cell-RIGHT__proliferation-_re789
type: Interaction
participant: proliferation
participant: neuronal stem cell s2276 sa1770
xref: KNOWN TRANSITION OMITTED

HETERODIMER_ASSOCIATION_LEFT__DAMPs-_TLR2-RIGHT__TLR2_DAMPs-_re1241
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1241 1965
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1241 1966
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1241 1967
conversion direction: LEFT_TO_RIGHT
left: DAMPs
left: TLR2
interaction type: HETERODIMER_ASSOCIATION
right: TLR2-DAMPs
spontaneous: true
xref: HETERODIMER ASSOCIATION

AmyloidB-ALB
type: Complex
component: AmyloidB
component: ALB
cellular location: CSF c16

STATE_TRANSITION_RIGHT__Insulin_IR-_re1326
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1326 2124
conversion direction: LEFT_TO_RIGHT
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Insulin-IR
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re134 206
type: Stoichiometry
physical entity: endosome lysosome s497 csa26
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re134 207
type: Stoichiometry
physical entity: csa30_degraded
stoichiometric coefficient: 1.0

Oligomeric AmyloidB
type: Protein

EIF2A s2469 sa1931 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EIF2A
stoichiometric coefficient: 1.0

WNT s289 sa485 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT
stoichiometric coefficient: 3.0

STATE_TRANSITION_LEFT__HPETE-RIGHT__LT-_unknown-_re113
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 187
conversion direction: LEFT_TO_RIGHT
left: HPETE s402 sa164
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: unknown
right: LT s81 sa158
xref: STATE TRANSITION

GRIN-Mg2+
type: Complex
component: GRIN
component: Mg2+
cellular location: neuron c1

UNKNOWN_TRANSITION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re304 465
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

CD247
type: Protein

PARTICIPANT STOICHIOMETRY re304 464
type: Stoichiometry
physical entity: NICD s972 sa682
stoichiometric coefficient: 1.0

Bile acids
type: SmallMolecule
cellular location: neuron c1

s2754
type: PhysicalEntity
cellular location: neuron c1

SAM
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re813 1309
type: Stoichiometry
physical entity: MAP2K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re813 1308
type: Stoichiometry
physical entity: MAP2K
stoichiometric coefficient: 1.0

WNT s2063 sa1580 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WNT s2063 sa1580
stoichiometric coefficient: 1.0

HRK s1907 sa1429 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HRK
stoichiometric coefficient: 1.0

CHRNA s2007 sa1515 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRNA
stoichiometric coefficient: 1.0

GSR
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1291 2041
type: Stoichiometry
physical entity: DHA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re646 1078
type: Stoichiometry
physical entity: F2A-isoprostanes
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1291 2042
type: Stoichiometry
physical entity: DHA
stoichiometric coefficient: 1.0

3-mercaptopyruvate
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re646 1077
type: Stoichiometry
physical entity: PG s78 sa157
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3288 csa249
type: Stoichiometry
physical entity: unkown receptor TNF s3288 csa249
stoichiometric coefficient: 1.0

PSD95
type: Protein
cellular location: neuron c1

TNFRSF21 s500 sa183 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFRSF21
stoichiometric coefficient: 1.0

sphingosine s2345 sa1824 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sphingosine
stoichiometric coefficient: 1.0

VCAM1 s1644 sa1258 STOICHIOMETRY ID
type: Stoichiometry
physical entity: VCAM1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re249 359
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re249 358
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

TNFRSF21
type: Protein
feature: TNFRSF21 TNFRSF21 s500 sa183 Active
cellular location: neuron c1

thiosulfate:thiol sulfurtransferase s1348 sa1012 STOICHIOMETRY ID
type: Stoichiometry
physical entity: thiosulfate:thiol sulfurtransferase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re271 398
type: Stoichiometry
physical entity: UB s892 sa603
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re271 399
type: Stoichiometry
physical entity: UBA1
stoichiometric coefficient: 1.0

TNFRSF1A-FADD-CASP8
type: Complex
component: FADD
component: CASP8
component: TNFRSF1A
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__Lipid_peroxidation-RIGHT__destruction_of_membranes-_re824
type: Interaction
participant: destruction of membranes
participant: Lipid peroxidation
xref: KNOWN TRANSITION OMITTED

PLA2G1B s3465 sa2171 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PLA2G1B
stoichiometric coefficient: 1.0

APOE s607 sa177 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APOE s607 sa177
stoichiometric coefficient: 3.0

STOICHIOMETRY ID s3258 csa55
type: Stoichiometry
physical entity: APC-GSK3B-AXIN-CTNNB1
stoichiometric coefficient: 1.0

FPRL1
type: Protein

KNOWN_TRANSITION_OMITTED_LEFT__NFKB1_RELA-RIGHT__dedifferentiation-_re1050
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: dedifferentiation
controller: NFKB1 RELA s3308 csa269

insulin
type: SmallMolecule
cellular location: neuron c1

UBE2M-ROC1-UBE2-NEDD8-CUL-SKP1-FBXO
type: Complex
component: SKP1 s794 sa513
component: UBE2M
component: FBXO s798 sa514
component: UBE2
component: CUL
component: ROC1
component: NEDD8 s827 sa510
cellular location: neuron c1

IL1B
type: Protein
cellular location: neuron c1

RAGE
type: Protein
cellular location: microglia c4

TNFA s3890 sa2784 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFA
stoichiometric coefficient: 1.0

JUN
type: Protein
cellular location: MAPK cascade c6

STOICHIOMETRY ID s3350 csa64
type: Stoichiometry
physical entity: UBA3 APPBP1 s3350 csa64
stoichiometric coefficient: 1.0

CLU s1574 sa2337 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CLU s1574 sa2337
stoichiometric coefficient: 2.0

GSK3B
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__SORL1-_APP-RIGHT__APP_SORL1-_re77
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 144
conversion direction: LEFT_TO_RIGHT
left: SORL1
left: APP
interaction type: HETERODIMER_ASSOCIATION
right: APP SORL1 s3275 csa13
spontaneous: true
xref: HETERODIMER ASSOCIATION

PPARG s1274 sa937 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARG
stoichiometric coefficient: 1.0

APP s3499 sa1230 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

AmyloidB-A2M
type: Complex
component: AmyloidB
component: A2M
cellular location: Brain c26

ATG13 s2157 sa1668 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG13
stoichiometric coefficient: 1.0

MAC: membrane attack complex
type: Complex
component: C5B
component: C7
component: C8
component: C6 s370 sa360
cellular location: microglia c4

HETERODIMER_ASSOCIATION_LEFT__UBE2M_NEDD8_E3_ubiquitin_ligase-_UBE2_UB-RIGHT__UBE2M_ROC1_UBE2_UB_NEDD8_CUL_SKP1_FBXO-_re267
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re267 397
participant stoichiometry: PARTICIPANT STOICHIOMETRY re267 395
participant stoichiometry: PARTICIPANT STOICHIOMETRY re267 396
conversion direction: LEFT_TO_RIGHT
left: UBE2-UB
left: UBE2M-NEDD8-E3 ubiquitin ligase
interaction type: HETERODIMER_ASSOCIATION
right: UBE2M-ROC1-UBE2-UB-NEDD8-CUL-SKP1-FBXO
spontaneous: true
xref: HETERODIMER ASSOCIATION

TNFRSF1A s1953 sa1462 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNFRSF1A
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3234 csa139
type: Stoichiometry
physical entity: FTH-ACO1-IREB2-Fe
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CASK-RIGHT__CASK-_re981
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re981 1617
participant stoichiometry: PARTICIPANT STOICHIOMETRY re981 1618
conversion direction: LEFT_TO_RIGHT
left: CASK
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CASK
xref: STATE TRANSITION

PTGS2
type: Protein
cellular location: neuron c1

ICAM1 s1640 sa1254 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ICAM1
stoichiometric coefficient: 1.0

CTNNB1 s267 sa468 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Mitochondrial_dysfunction-RIGHT__CYC-_re298
type: Interaction
participant: Mitochondrial dysfunction s462 sa81
participant: CYC
xref: KNOWN TRANSITION OMITTED

Fe s1455 sa1110 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Fe s1455 sa1110
stoichiometric coefficient: 3.0

IL6
type: Protein
feature: IL6 IL6 s3468 sa2452 Active
cellular location: neuron c1

TNFRSF1A-FADD
type: Complex
component: FADD
component: TNFRSF1A
cellular location: neuron c1

Kv3.4 s3789 sa2701 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Kv3.4 s3789 sa2701
stoichiometric coefficient: 1.0

AmyloidB1-42
type: Protein

MAPK
type: Pathway

TIMP1 s456 sa173 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TIMP1
stoichiometric coefficient: 11.0

MAPK8IP1
type: Protein

HNE s2704 sa2181 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HNE
stoichiometric coefficient: 1.0

HMG CoA
type: SmallMolecule
cellular location: neuron c1

LRP8
type: Protein
cellular location: neuron c1

TP53
type: Protein
cellular location: neuron c1

HAT1
type: Protein

Q s169 sa292 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Q
stoichiometric coefficient: 2.0

KNOWN_TRANSITION_OMITTED_LEFT__phosphatidylcholine-RIGHT__AA-_re1141
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1141 1788
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1141 1789
conversion direction: LEFT_TO_RIGHT
left: phosphatidylcholine s3566 sa2472
interaction type: KNOWN_TRANSITION_OMITTED
right: AA
xref: KNOWN TRANSITION OMITTED

APC
type: Protein
feature: APC APC s763 sa475 rs1

60S s1500 sa2328 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 60S s1500 sa2328
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re907 1504
type: Stoichiometry
physical entity: TF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1085 1723
type: Stoichiometry
physical entity: PPARA ligands-PPARA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1085 1722
type: Stoichiometry
physical entity: PPARA ligands
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1085 1721
type: Stoichiometry
physical entity: PPARA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re907 1503
type: Stoichiometry
physical entity: TF
stoichiometric coefficient: 1.0

NUDT6
type: Protein
cellular location: microglia c4

TP53
type: Protein
feature: TP53 TP53 s2799 sa18 Active
cellular location: neuron c1

NFAT
type: Protein
feature: NFAT NFAT s2438 sa1913 Active
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re1203 1892
type: Stoichiometry
physical entity: TNFA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1203 1891
type: Stoichiometry
physical entity: TNFA s3648 sa2558
stoichiometric coefficient: 1.0

presynaptic terminal c11
type: CellularLocationVocabulary
comment: _presynaptic_terminal

STATE_TRANSITION_LEFT__RHEB-RIGHT__RHEB-_re891
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re891 1465
participant stoichiometry: PARTICIPANT STOICHIOMETRY re891 1466
conversion direction: LEFT_TO_RIGHT
left: RHEB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: RHEB
xref: STATE TRANSITION

re258 s2927 sa2301 374
type: Control
xref: UNKNOWN INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__CTNNB1-_APC_GSK3B_AXIN-_re258
control type: INHIBITION
controller: AKT1

STOICHIOMETRY ID s3331 csa28
type: Stoichiometry
physical entity: PRNP-Oligomeric AmyloidB
stoichiometric coefficient: 1.0

DAB1 s2092 sa1611 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DAB1
stoichiometric coefficient: 1.0

HMGCR
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1173 1843
type: Stoichiometry
physical entity: NALP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1173 1844
type: Stoichiometry
physical entity: NALP-AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1173 1842
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__EDN1-RIGHT__EDN1-_re567
type: TemplateReaction
participant: EDN1 s1642 sa1256
participant: EDN1
product: EDN1 s1642 sa1256
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

2GSH s1367 sa1033 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 2GSH
stoichiometric coefficient: 1.0

R SH s1330 sa994 STOICHIOMETRY ID
type: Stoichiometry
physical entity: R-SH
stoichiometric coefficient: 1.0

NADH s1059 sa767 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

inflammasome
type: Protein
cellular location: microglia c4

EIF2A
type: Protein
feature: EIF2A EIF2A s2470 sa1932 rs1
feature: EIF2A EIF2A s2470 sa1932 Active
cellular location: neuron c1

TX s65 sa2166 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TX
stoichiometric coefficient: 1.0

ALLOP s2874 sa2278 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

Lipoprotein remnant
type: SmallMolecule

inflammasome
type: Protein
feature: inflammasome inflammasome s3724 sa2636 Active
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re846 1377
type: Stoichiometry
physical entity: PPP3
stoichiometric coefficient: 1.0

ICAM1
type: RnaRegion
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re778 1250
type: Stoichiometry
physical entity: TNF s2777 sa2241
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re846 1376
type: Stoichiometry
physical entity: PPP3
stoichiometric coefficient: 1.0

AGE s3873 sa2790 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AGE s3873 sa2790
stoichiometric coefficient: 1.0

PEBP1
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re838 1356
type: Stoichiometry
physical entity: GGPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re838 1357
type: Stoichiometry
physical entity: RHOA-GGPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re838 1355
type: Stoichiometry
physical entity: RHOA
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__IL1B-RIGHT__IL1B-_re1178
type: TemplateReaction
participant: IL1B
product: IL1B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

STATE_TRANSITION_LEFT__HSP60-RIGHT__HSP60-_re1255
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1255 1994
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1255 1993
conversion direction: LEFT_TO_RIGHT
left: HSP60
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HSP60
xref: STATE TRANSITION

Glc6P
type: SmallMolecule
cellular location: neuron c1

glutamate-GRIN
type: Complex
component: GRIN s1992 sa886
component: glutamate s1206 sa1497
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re553 936
type: Stoichiometry
physical entity: NFKB1 s1586 sa1221
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re381 635
type: Stoichiometry
physical entity: MAPK8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re553 937
type: Stoichiometry
physical entity: NFKB1 s1589 sa1224
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re381 636
type: Stoichiometry
physical entity: APAF1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_CHRN_-RIGHT__CHRN_AmyloidB-_re928
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re928 1541
participant stoichiometry: PARTICIPANT STOICHIOMETRY re928 1542
participant stoichiometry: PARTICIPANT STOICHIOMETRY re928 1540
conversion direction: LEFT_TO_RIGHT
left: CHRN
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: CHRN-AmyloidB
spontaneous: true
xref: HETERODIMER ASSOCIATION

5 MTHF s1518 sa1163 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 5 MTHF s1518 sa1163
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re271 400
type: Stoichiometry
physical entity: UBA1-UB
stoichiometric coefficient: 1.0

paired helical filaments(PHFs)
type: Pathway

APBA1
type: Protein

PARTICIPANT STOICHIOMETRY re778 1249
type: Stoichiometry
physical entity: TNF s2777 sa2240
stoichiometric coefficient: 1.0

polo-kinase
type: Protein
cellular location: neuron c1

Oligomeric AmyloidB s57 sa71 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Oligomeric AmyloidB
stoichiometric coefficient: 10.0

HETERODIMER_ASSOCIATION_LEFT__NGF-_NTRK1-RIGHT__NTRK1_NGF-_re317
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 490
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 491
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 492
conversion direction: LEFT_TO_RIGHT
left: NTRK1 s1017 sa728
left: NGF
interaction type: HETERODIMER_ASSOCIATION
right: NTRK1 NGF s3176 csa102
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re481 790
type: Stoichiometry
physical entity: sulfinyl pyruvate
stoichiometric coefficient: 1.0

DR6 s3654 sa2568 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DR6 s3654 sa2568
stoichiometric coefficient: 1.0

Li+
type: SmallMolecule
cellular location: neuron c1

TRANSLATION_LEFT__IL1B-RIGHT__IL1B-_re1166
type: TemplateReaction
participant: IL1B
product: IL1B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

sulfite s1333 sa997 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sulfite
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1342 2174
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__APP_-RIGHT__APP_-_re1342
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1342 2174
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1342 2173
conversion direction: LEFT_TO_RIGHT
left: APP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APP
xref: STATE TRANSITION

LRP s3859 sa2780 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PTGS2-RIGHT__PTGS2-_re956
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re956 1568
participant stoichiometry: PARTICIPANT STOICHIOMETRY re956 1569
conversion direction: LEFT_TO_RIGHT
left: PTGS2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PTGS2
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1342 2173
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re481 789
type: Stoichiometry
physical entity: L-Cysteinesulfinate
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Lipid_raft__increase-RIGHT__AmyloidB_production_increase-_re1346
type: Interaction
participant: Lipid raft increase s3934 sa2852
participant: AmyloidB production increase
xref: KNOWN TRANSITION OMITTED

UBE2M-NEDD8-E3 ubiquitin ligase
type: Complex
component: UBE2M
component: E3 ubiquitin-ligase
component: NEDD8 s827 sa510
cellular location: neuron c1

STATE_TRANSITION_LEFT__L_Cys-RIGHT__3_mercaptopyruvate-_re475
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re475 769
participant stoichiometry: PARTICIPANT STOICHIOMETRY re475 770
conversion direction: LEFT_TO_RIGHT
left: L-Cys
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: 3-mercaptopyruvate
xref: STATE TRANSITION

INPP5K s2547 sa2009 STOICHIOMETRY ID
type: Stoichiometry
physical entity: INPP5K
stoichiometric coefficient: 2.0

humanin
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re141 217
type: Stoichiometry
physical entity: cholesterol s87 sa190
stoichiometric coefficient: 1.0

IRS2
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re141 218
type: Stoichiometry
physical entity: cholesterol
stoichiometric coefficient: 5.0

PARTICIPANT STOICHIOMETRY re1330 2130
type: Stoichiometry
physical entity: Insulin-NMDAR
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_NMDAR-RIGHT__AmyloidB_NMDAR-_re1317
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1317 2095
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1317 2094
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1317 2093
conversion direction: LEFT_TO_RIGHT
left: NMDAR
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB-NMDAR
spontaneous: true
xref: HETERODIMER ASSOCIATION

H2O s2696 sa2173 STOICHIOMETRY ID
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__IL4R-_IL4-RIGHT__IL4_IL4R-_re1207
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1207 1897
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1207 1899
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1207 1898
conversion direction: LEFT_TO_RIGHT
left: IL4R
left: IL4
interaction type: HETERODIMER_ASSOCIATION
right: IL4-IL4R
spontaneous: true
xref: HETERODIMER ASSOCIATION

Met s1121 sa822 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Met
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RIPK2-RIGHT__RIPK2-_re1240
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1240 1963
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1240 1964
conversion direction: LEFT_TO_RIGHT
left: RIPK2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: RIPK2
xref: STATE TRANSITION

IFI44 s2790 sa1857 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IFI44 s2790 sa1857
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_SRA1-RIGHT__SRA1_AmyloidB-_re1221
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1221 1931
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1221 1932
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1221 1933
conversion direction: LEFT_TO_RIGHT
left: SRA1
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: SRA1 AmyloidB s3702 csa297
spontaneous: true
xref: HETERODIMER ASSOCIATION

Nerve regeneration
type: Pathway

PARTICIPANT STOICHIOMETRY re1330 2129
type: Stoichiometry
physical entity: NMDAR
stoichiometric coefficient: 1.0

CBS
type: Protein
feature: CBS CBS s1373 sa1041 Active
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1330 2128
type: Stoichiometry
physical entity: insulin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re975 1600
type: Stoichiometry
physical entity: APP APBB1 ABL s3325 csa256
stoichiometric coefficient: 1.0

CD247 s2465 sa2372 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD247
stoichiometric coefficient: 2.0

NICD s973 sa683 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

N APP s504 sa385 STOICHIOMETRY ID
type: Stoichiometry
physical entity: N APP s504 sa385
stoichiometric coefficient: 1.0

oxidative stress
type: Pathway

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

UBE2M
type: Protein

GSK3B s62 sa88 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 2.0

AXIN s1697 sa471 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AXIN
stoichiometric coefficient: 4.0

MMP2
type: Protein
cellular location: default

HETERODIMER_ASSOCIATION_LEFT__HAT1-_NICD-RIGHT__NICD_HAT1-_re879
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re879 1430
participant stoichiometry: PARTICIPANT STOICHIOMETRY re879 1429
participant stoichiometry: PARTICIPANT STOICHIOMETRY re879 1431
conversion direction: LEFT_TO_RIGHT
left: NICD
left: HAT1
interaction type: HETERODIMER_ASSOCIATION
right: NICD-HAT1
spontaneous: true
xref: HETERODIMER ASSOCIATION

PG s397 sa166 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PG
stoichiometric coefficient: 1.0

IL1B
type: RnaRegion
cellular location: astrocyte c2

APP-SHC1
type: Complex
component: APP
component: SHC1 s2737 sa2205
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1137 1785
type: Stoichiometry
physical entity: NPC s513 sa187
stoichiometric coefficient: 1.0

HS-
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1137 1784
type: Stoichiometry
physical entity: cholesterol s3164 sa188
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1137 1786
type: Stoichiometry
physical entity: NPC cholesterol s3382 csa282
stoichiometric coefficient: 1.0

AmyloidB1-42-APOE
type: Complex
component: AmyloidB1-42
component: APOE s470 sa315
cellular location: default

SFRP
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re715 1152
type: Stoichiometry
physical entity: NFKBI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re715 1153
type: Stoichiometry
physical entity: NFKBI
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__ATP1-RIGHT__depolarization-_re953
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: depolarization
controller: ATP1 s3483 sa2131

IRS2
type: Protein
feature: IRS2 IRS2 s3882 sa2800 Active
cellular location: neuron c1

H+
type: SmallMolecule
cellular location: inner membrane c8

STATE_TRANSITION_LEFT__DR6-RIGHT__Apoptosis-_re1193
type: Control
xref: STATE TRANSITION
controlled: Apoptosis
controller: DR6 s3654 sa2568

PARTICIPANT STOICHIOMETRY re1211 1913
type: Stoichiometry
physical entity: FPRL1 lipoxinA4 s3677 csa293
stoichiometric coefficient: 1.0

FPRL1
type: RnaRegion
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re744 1189
type: Stoichiometry
physical entity: MAP2K1 s2136 sa1650
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1211 1912
type: Stoichiometry
physical entity: FPRL1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1211 1911
type: Stoichiometry
physical entity: lipoxin A4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re744 1188
type: Stoichiometry
physical entity: MAP2K1 s2136 sa1649
stoichiometric coefficient: 1.0

HSP60
type: Protein
cellular location: default

s3840 s3840 sa2749 STOICHIOMETRY ID
type: Stoichiometry
physical entity: s3840 s3840 sa2749
stoichiometric coefficient: 1.0

humanin s3818 sa2726 STOICHIOMETRY ID
type: Stoichiometry
physical entity: humanin
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__DA-RIGHT__NE-_re535
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re535 900
participant stoichiometry: PARTICIPANT STOICHIOMETRY re535 899
conversion direction: LEFT_TO_RIGHT
left: DA
interaction type: KNOWN_TRANSITION_OMITTED
right: NE
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re654 1092
type: Stoichiometry
physical entity: NFKBI
stoichiometric coefficient: 1.0

HMGB1 s3470 sa2450 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HMGB1
stoichiometric coefficient: 1.0

NTF3 s2318 sa1798 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTF3
stoichiometric coefficient: 2.0

PTGS2 s394 sa154 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PTGS2
stoichiometric coefficient: 1.0

NADP PLUS s1045 sa752 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NADP PLUS s1045 sa752
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re654 1093
type: Stoichiometry
physical entity: s2754
stoichiometric coefficient: 1.0

LTP impairment
type: Pathway

S
type: Pathway

HETERODIMER_ASSOCIATION_LEFT__E3_ubiquitin_ligase-_UBE2M_NEDD8-RIGHT__UBE2M_NEDD8_E3_ubiquitin_ligase-_re264
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re264 394
participant stoichiometry: PARTICIPANT STOICHIOMETRY re264 392
participant stoichiometry: PARTICIPANT STOICHIOMETRY re264 393
conversion direction: LEFT_TO_RIGHT
left: UBE2M NEDD8 s3355 csa65
left: E3 ubiquitin-ligase
interaction type: HETERODIMER_ASSOCIATION
right: UBE2M-NEDD8-E3 ubiquitin ligase
spontaneous: true
xref: HETERODIMER ASSOCIATION

SFRP s2040 sa1553 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SFRP s2040 sa1553
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3214 csa116
type: Stoichiometry
physical entity: CALM Ca2 PLUS s3214 csa116
stoichiometric coefficient: 1.0

O2
type: SmallMolecule
cellular location: neuron c1

PRIM1 s2954 sa400 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRIM1
stoichiometric coefficient: 3.0

CD3G
type: Protein
feature: CD3G CD3G s2462 sa2369 rs1

STOICHIOMETRY ID s3289 csa251
type: Stoichiometry
physical entity: CHRN-AmyloidB
stoichiometric coefficient: 1.0

GTPase s2866 sa2271 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GTPase
stoichiometric coefficient: 1.0

Tyr s1528 sa1173 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Tyr
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re795 1281
type: Stoichiometry
physical entity: NTRK3-NTF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re795 1280
type: Stoichiometry
physical entity: NTRK3
stoichiometric coefficient: 1.0

C1Q
type: Protein

PARTICIPANT STOICHIOMETRY re1314 2083
type: Stoichiometry
physical entity: AMPAR s3851 sa2770
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__COX2-RIGHT__PGE2-_re1184
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1184 1868
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1184 1867
conversion direction: LEFT_TO_RIGHT
left: COX2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PGE2
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re696 1123
type: Stoichiometry
physical entity: s2025 s2025 sa1545
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1314 2084
type: Stoichiometry
physical entity: AMPAR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re696 1122
type: Stoichiometry
physical entity: LRP5/6
stoichiometric coefficient: 1.0

HMGCR s1087 sa791 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HMGCR
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3472 csa174
type: Stoichiometry
physical entity: NFKBI-NFKB1-RELA
stoichiometric coefficient: 2.0

R-SH
type: SmallMolecule
cellular location: neuron c1

FNTA s2401 sa1947 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FNTA
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3180 csa6
type: Stoichiometry
physical entity: TNFRSF1A-FADD
stoichiometric coefficient: 2.0

APAF1-CASP9
type: Complex
component: CASP9
component: APAF1
cellular location: neuron c1

UNKNOWN_TRANSITION_LEFT__MIF-RIGHT__Inflammation-_re1135
type: Control
xref: UNKNOWN TRANSITION
controlled: Inflammation s167 sa104
controller: MIF

CASP2
type: Protein

NR1H s526 sa388 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NR1H
stoichiometric coefficient: 1.0

Tyr
type: SmallMolecule
cellular location: neuron c1

CHRM
type: Protein
feature: CHRM CHRM s2839 sa736 Active

KNOWN_TRANSITION_OMITTED_LEFT__Mitochondrial_dysfunction-RIGHT__Caspase_cascade-_re1154
type: Interaction
participant: Mitochondrial dysfunction s3572 sa2480
participant: Caspase cascade
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re1292 2044
type: Stoichiometry
physical entity: 17S HpDHA s3825 sa2734
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1292 2045
type: Stoichiometry
physical entity: 16,17S-DHA Epoxide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re795 1279
type: Stoichiometry
physical entity: NTF3
stoichiometric coefficient: 1.0

CBS
type: Protein
cellular location: neuron c1

AKT1S1
type: Protein
cellular location: neuron c1

HSD17B10 s122 sa2323 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSD17B10
stoichiometric coefficient: 1.0

MAP3K9/10/11
type: Protein
feature: MAP3K9 10 11 MAP3K9 10 11 s2881 sa1425 Active
feature: MAP3K9 10 11 MAP3K9 10 11 s2881 sa1425 rs1
cellular location: MAPK cascade c6

EGF s1412 sa1073 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EGF s1412 sa1073
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1208 1902
type: Stoichiometry
physical entity: PPARG ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1208 1901
type: Stoichiometry
physical entity: PPARG ligand
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3359 csa167
type: Stoichiometry
physical entity: LDLR-APOE-Lipoprotein remnant
stoichiometric coefficient: 1.0

NFKB
type: Protein
cellular location: microglia c4

mevalonic acid
type: SmallMolecule
cellular location: neuron c1

THSD1
type: Protein
cellular location: astrocyte c2

STATE_TRANSITION_LEFT__TNF-RIGHT__TNF-_re1133
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1133 1782
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1133 1783
conversion direction: LEFT_TO_RIGHT
left: TNF
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TNF
xref: STATE TRANSITION

NTRK1 s1021 sa730 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NTRK1 s1021 sa730
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__MAPT-RIGHT__paired_helical_filaments_PHFs_-_re44
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: paired helical filaments(PHFs)
controller: MAPT s151 sa91

PARTICIPANT STOICHIOMETRY re899 1481
type: Stoichiometry
physical entity: PCSK1 s2607 sa2070
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re899 1482
type: Stoichiometry
physical entity: PCSK1 s2607 sa2071
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re496 824
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

LIPC
type: Protein

TNF s3471 sa2454 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re496 825
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__RAGE_AmyloidB-RIGHT__LTP_impairment-_re1287
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: LTP impairment
controller: RAGE AmyloidB s3804 csa310

C1 s1119 sa821 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C1 s1119 sa821
stoichiometric coefficient: 1.0

ceramidase
type: Protein
feature: ceramidase ceramidase s2347 sa1826 Active
cellular location: neuron c1

FPRL1-AmyloidB1-42
type: Complex
component: AmyloidB1-42
component: FPRL1
cellular location: microglia c4

re245 s3253 csa155 340
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__FZD_LRP5_6_CSNK1A1-_WNT-RIGHT__FZD_WNT_LRP5_6-_CSNK1A1-_re245
control type: INHIBITION
controller: DKK1-KREMEN2-LRP5/6

CAPN s3447 sa5 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CAPN s3447 sa5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1054 1655
type: Stoichiometry
physical entity: NFKB1 RELA s3308 csa269
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__60S-RIGHT__60S-_re1007
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1007 1636
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1007 1635
conversion direction: LEFT_TO_RIGHT
left: 60S
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: 60S s1500 sa2328
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1054 1656
type: Stoichiometry
physical entity: NFKB1-RELA
stoichiometric coefficient: 1.0

AGE
type: SmallMolecule

PARTICIPANT STOICHIOMETRY re429 720
type: Stoichiometry
physical entity: C3A AmyloidB1 42 s3503 csa124
stoichiometric coefficient: 1.0

G1/S checkpoint
type: Pathway

AmyloidB
type: Protein
cellular location: CSF c16

STATE_TRANSITION_LEFT__PRKC-RIGHT__PRKC-_re593
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re593 995
participant stoichiometry: PARTICIPANT STOICHIOMETRY re593 994
conversion direction: LEFT_TO_RIGHT
left: PRKC s1786 sa1318
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PRKC s1787 sa1319
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1057 1662
type: Stoichiometry
physical entity: GRIA-glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1057 1660
type: Stoichiometry
physical entity: GRIA
stoichiometric coefficient: 1.0

s1016
type: PhysicalEntity
cellular location: default

PARTICIPANT STOICHIOMETRY re1057 1661
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

SMPD2
type: Protein
feature: SMPD2 SMPD2 s1514 sa1159 Active
cellular location: Golgi apparatus c20

TLR9
type: Protein
cellular location: microglia c4

CDO
type: Protein
cellular location: neuron c1

SMPD
type: Protein
cellular location: neuron c1

GSK3B s909 sa87 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3341 csa33
type: Stoichiometry
physical entity: PRIM1-PCLB-APEX1-POLD1-replication origin
stoichiometric coefficient: 1.0

Phosphoglucose isomerase
type: Protein
cellular location: neuron c1

s235
type: Complex
component: VPS35 s257 sa370
component: VPS29
component: VPS26A
component: SNX

KNOWN_TRANSITION_OMITTED_LEFT__MAPT_-RIGHT__cytoaarchitectural_integrity-_re731
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: cytoaarchitectural integrity
controller: MAPT s3448 sa85

Hexokinase s3912 sa2829 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Hexokinase
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Fru6P-_glutamine-RIGHT__GlcNH26P-_glutamate-_re1335
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1335 2146
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1335 2148
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1335 2147
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1335 2149
conversion direction: LEFT_TO_RIGHT
left: glutamine s3920 sa2837
left: Fru6P
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: glutamate
right: GlcNH26P
xref: STATE TRANSITION

VPS29-VPS35-SNX-VPS26A
type: Complex
component: VPS29
component: VPS35 s257 sa370
component: VPS26A
component: SNX
cellular location: neuron c1

TRANSCRIPTION_LEFT__HRK-RIGHT__HRK-_re633
type: TemplateReaction
participant: HRK s1906 sa1428
participant: HRK
product: HRK s1906 sa1428
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

CASP7 s101 sa217 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP7 s101 sa217
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__G2_M_checkpoint-RIGHT__Cell_Death-_re993
type: Interaction
participant: Cell Death s119 sa77
participant: G2/M checkpoint
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re41 83
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

Ubiquinone
type: SmallMolecule
cellular location: neuron c1

STATE_TRANSITION_LEFT__NALP1-RIGHT__NALP1-_re1269
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1269 2009
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1269 2008
conversion direction: LEFT_TO_RIGHT
left: NALP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NALP1
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re41 82
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

ATG10
type: Protein

STATE_TRANSITION_LEFT__NEDD8-RIGHT__NEDD8-_re262
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re262 388
participant stoichiometry: PARTICIPANT STOICHIOMETRY re262 387
conversion direction: LEFT_TO_RIGHT
left: NEDD8
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NEDD8
xref: STATE TRANSITION

PRIM1-PCLB-APEX1-POLD1-replication origin
type: Complex
component: POLD1
component: PRIM1
component: replication origin
component: APEX1 s1678 sa406
component: POLB
cellular location: DNAreplification c9

AmyloidB
type: Protein

POLB
type: Protein
cellular location: DNAreplification c9

PARTICIPANT STOICHIOMETRY re429 719
type: Stoichiometry
physical entity: C3A-AmyloidB1-42
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re204 293
type: Stoichiometry
physical entity: PDH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re204 294
type: Stoichiometry
physical entity: PDH
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__pyruvate-RIGHT__pyruvate-_re203
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re203 290
participant stoichiometry: PARTICIPANT STOICHIOMETRY re203 291
conversion direction: LEFT_TO_RIGHT
left: pyruvate s653 sa251
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: pyruvate
xref: TRANSPORT

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re400
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re400 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY re400 664
conversion direction: LEFT_TO_RIGHT
left: K+
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: K+
xref: TRANSPORT

PARTICIPANT STOICHIOMETRY re974 1597
type: Stoichiometry
physical entity: APBB1 AICD LBP 1 TFCP2 PCBP2 s3375 csa255
stoichiometric coefficient: 1.0

PDK1 s915 sa635 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PDK1 s915 sa635
stoichiometric coefficient: 1.0

NFKBI-NFKB1-RELA
type: Complex
component: NFKBI
component: RELA
component: NFKB1
cellular location: neuron c1

GPCR s2119 sa1635 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GPCR
stoichiometric coefficient: 1.0

WNT3A
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re974 1595
type: Stoichiometry
physical entity: APBB1-AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re974 1596
type: Stoichiometry
physical entity: LBP-1-TFCP2-PCBP2
stoichiometric coefficient: 1.0

AP1
type: Protein
feature: AP1 AP1 s2353 sa1834 Active
cellular location: nucleus c3

NGFR
type: Protein
cellular location: neuron c1

AGE-RAGE
type: Complex
component: RAGE
component: AGE
cellular location: default

IL6
type: RnaRegion
cellular location: microglia c4

synaptic vesicle release
type: Pathway

HSCoA
type: SmallMolecule
cellular location: neuron c1

ADAM10
type: Protein
cellular location: neuron c1

FTH s1470 sa1127 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FTH
stoichiometric coefficient: 4.0

STATE_TRANSITION_LEFT__MY-RIGHT__actin_organization-_re702
type: Control
xref: STATE TRANSITION
controlled: actin organization s2047 sa1562
controller: MY

MAP2K4
type: Protein
feature: MAP2K4 MAP2K4 s1902 sa1424 rs1
feature: MAP2K4 MAP2K4 s1902 sa1424 Active
cellular location: MAPK cascade c6

NOS
type: Protein
cellular location: neuron c1

AP1
type: Protein
cellular location: nucleus c3

GABA s3564 sa774 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 4.0

speck-like protein
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re296 459
type: Stoichiometry
physical entity: UB s937 sa658
stoichiometric coefficient: 5.0

PARTICIPANT STOICHIOMETRY re296 460
type: Stoichiometry
physical entity: UB s892 sa603
stoichiometric coefficient: 1.0

ATG5 s2182 sa1692 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG5
stoichiometric coefficient: 1.0

PGG2 s400 sa160 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PGG2 s400 sa160
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re261 383
type: Stoichiometry
physical entity: APPBP1
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: inner membrane c8

RAGE
type: Protein

ADAM17
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re1359 2177
type: Stoichiometry
physical entity: sphingoshine1-P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1359 2176
type: Stoichiometry
physical entity: sphingosine
stoichiometric coefficient: 1.0

MSRA
type: Protein
cellular location: neuron c1

PDE5A
type: Protein
cellular location: presynaptic terminal c11

NALP
type: Protein
cellular location: microglia c4

5'GMP
type: SmallMolecule
cellular location: presynaptic terminal c11

PARTICIPANT STOICHIOMETRY re261 384
type: Stoichiometry
physical entity: UBA3
stoichiometric coefficient: 1.0

DAB s1728 sa1272 STOICHIOMETRY ID
type: Stoichiometry
physical entity: DAB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re261 385
type: Stoichiometry
physical entity: UBA3 APPBP1 s3350 csa64
stoichiometric coefficient: 1.0

ATG12-ATG5-ATG16
type: Complex
component: ATG5
component: ATG12
component: ATG16
cellular location: neuron c1

TF s2921 sa2084 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TF
stoichiometric coefficient: 1.0

SAMe
type: SmallMolecule
cellular location: neuron c1

GSK3B s3264 sa488 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSK3B s3264 sa488
stoichiometric coefficient: 1.0

FZD
type: Protein

GABR s3092 sa783 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GABR s3092 sa783
stoichiometric coefficient: 1.0

re172 s2927 sa2301 266
type: Control
xref: INHIBITION
controlled: HETERODIMER ASSOCIATION LEFT APAF1- CASP9-RIGHT APAF1 CASP9- re172
control type: INHIBITION
controller: AKT1

ATG17
type: Protein

PARTICIPANT STOICHIOMETRY re335 528
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

ACO1 s1458 sa1114 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ACO1 s1458 sa1114
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re335 529
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

C2
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re1036 1647
type: Stoichiometry
physical entity: GGPP
stoichiometric coefficient: 1.0

re35 s57 sa71 46
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__COX-RIGHT__COX-_re35
control type: INHIBITION
controller: Oligomeric AmyloidB

cytoaarchitectural integrity
type: Pathway

humanin
type: Protein

HETERODIMER_ASSOCIATION_LEFT__Insulin_receptor-_insulin-_re1327
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1327 2126
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1327 2127
conversion direction: LEFT_TO_RIGHT
left: Insulin receptor
left: insulin
interaction type: HETERODIMER_ASSOCIATION
xref: HETERODIMER ASSOCIATION

HETERODIMER_ASSOCIATION_LEFT__glutamate-_GR-RIGHT__glutamate_GR-_re401
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re401 666
participant stoichiometry: PARTICIPANT STOICHIOMETRY re401 668
participant stoichiometry: PARTICIPANT STOICHIOMETRY re401 667
conversion direction: LEFT_TO_RIGHT
left: GR s1191 sa881
left: glutamate
interaction type: HETERODIMER_ASSOCIATION
right: glutamate-GR
spontaneous: true
xref: HETERODIMER ASSOCIATION

TUB
type: Protein
feature: TUB TUB s931 sa650 rs1

PARTICIPANT STOICHIOMETRY re1036 1646
type: Stoichiometry
physical entity: Farnesyl PP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1338 2157
type: Stoichiometry
physical entity: GlcNAc1P
stoichiometric coefficient: 1.0

insulin s3880 sa2798 STOICHIOMETRY ID
type: Stoichiometry
physical entity: insulin
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1338 2158
type: Stoichiometry
physical entity: UDP-GlcNAc
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__tissue_injured-RIGHT__DAMPs-_re1248
type: Interaction
participant: DAMPs
participant: tissue injured
xref: KNOWN TRANSITION OMITTED

HETERODIMER_ASSOCIATION_LEFT__gro_LEF1_HDAC_TCF-_CTNNB1-RIGHT__gro-_TCF_LEF1_CTNNB1-_HDAC-_re252
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re252 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY re252 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY re252 364
participant stoichiometry: PARTICIPANT STOICHIOMETRY re252 367
participant stoichiometry: PARTICIPANT STOICHIOMETRY re252 366
conversion direction: LEFT_TO_RIGHT
left: CTNNB1
left: gro-LEF1-HDAC-TCF
interaction type: HETERODIMER_ASSOCIATION
right: HDAC
right: gro s1753 sa1291
right: TCF LEF1 CTNNB1 s3300 csa62
spontaneous: true
xref: HETERODIMER ASSOCIATION

HETERODIMER_ASSOCIATION_LEFT__ITPR-_IP3-RIGHT__ITPR_IP3-_re1077
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1077 1698
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1077 1700
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1077 1699
conversion direction: LEFT_TO_RIGHT
left: IP3
left: ITPR s129 sa108
interaction type: HETERODIMER_ASSOCIATION
right: ITPR-IP3
spontaneous: true
xref: HETERODIMER ASSOCIATION

LRP1 s3389 sa2334 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LRP1
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__NO-RIGHT__NO-_re408
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re408 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY re408 681
conversion direction: LEFT_TO_RIGHT
left: NO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: NO
xref: TRANSPORT

TRANSPORT_LEFT__NO-RIGHT__NO-_re409
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re409 683
participant stoichiometry: PARTICIPANT STOICHIOMETRY re409 684
conversion direction: LEFT_TO_RIGHT
left: NO
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: NO
xref: TRANSPORT

DAB
type: Protein
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__PRNP_Oligomeric_AmyloidB-RIGHT__Synaptic_suppression-_re139
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Synaptic suppression
controller: PRNP-Oligomeric AmyloidB

KNOWN_TRANSITION_OMITTED_LEFT__oxidative_stress-RIGHT__Microglia_Activation-_re626
type: Interaction
participant: Microglia Activation
participant: oxidative stress
xref: KNOWN TRANSITION OMITTED

KNOWN_TRANSITION_OMITTED_LEFT__NFKB1_RELA-RIGHT__survival-_re1051
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: survival
controller: NFKB1 RELA s3308 csa269

peroxynitrite (ONOO-)
type: SmallMolecule
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re345 553
type: Stoichiometry
physical entity: DMAPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re345 552
type: Stoichiometry
physical entity: IPP
stoichiometric coefficient: 1.0

ACO1
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__mutant_PSEN-_KCNIP3-RIGHT__KCNIP3_mutant_PSEN-_re1069
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1069 1684
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1069 1683
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1069 1682
conversion direction: LEFT_TO_RIGHT
left: KCNIP3
left: mutant PSEN
interaction type: HETERODIMER_ASSOCIATION
right: KCNIP3-mutant PSEN
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re292 453
type: Stoichiometry
physical entity: UBA1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re292 452
type: Stoichiometry
physical entity: UBA1 s898 sa615
stoichiometric coefficient: 1.0

O-GlcNAcylated MAPT
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re292 454
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GTP-RIGHT__cGMP-_re412
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re412 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY re412 692
conversion direction: LEFT_TO_RIGHT
left: GTP s1259 sa926
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: cGMP
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re292 451
type: Stoichiometry
physical entity: ATP s890 sa613
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1213 1919
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1213 1918
type: Stoichiometry
physical entity: AmyloidB1-42
stoichiometric coefficient: 1.0

proMMP9
type: Protein
cellular location: default

2GSH
type: SmallMolecule
cellular location: mitochondria c7

PTGS2 s395 sa155 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PTGS2 s395 sa155
stoichiometric coefficient: 1.0

ZAP70
type: Protein
feature: ZAP70 ZAP70 s3023 sa2373 rs1
feature: ZAP70 ZAP70 s3023 sa2373 Active
cellular location: neuron c1

Growth Factor s297 sa137 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Growth Factor s297 sa137
stoichiometric coefficient: 1.0

EDN1 s1624 sa1248 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EDN1
stoichiometric coefficient: 1.0

GGTI
type: Protein
cellular location: neuron c1

TRANSPORT_LEFT__ALLOP-RIGHT__ALLOP-_re335
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re335 528
participant stoichiometry: PARTICIPANT STOICHIOMETRY re335 529
conversion direction: LEFT_TO_RIGHT
left: ALLOP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ALLOP
xref: TRANSPORT

TRANSPORT_LEFT__ALLOP-RIGHT__ALLOP-_re334
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re334 527
participant stoichiometry: PARTICIPANT STOICHIOMETRY re334 526
conversion direction: LEFT_TO_RIGHT
left: ALLOP s3565 sa2273
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ALLOP s2869 sa2274
xref: TRANSPORT

TRANSPORT_LEFT__ALLOP-RIGHT__ALLOP-_re333
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re333 524
participant stoichiometry: PARTICIPANT STOICHIOMETRY re333 525
conversion direction: LEFT_TO_RIGHT
left: ALLOP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ALLOP
xref: TRANSPORT

TRANSPORT_LEFT__ALLOP-RIGHT__ALLOP-_re332
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re332 522
participant stoichiometry: PARTICIPANT STOICHIOMETRY re332 523
conversion direction: LEFT_TO_RIGHT
left: ALLOP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ALLOP s3565 sa2273
xref: TRANSPORT

re9 s456 sa942 6
type: Control
xref: INHIBITION
control type: INHIBITION
controller: TIMP1

STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re636
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re636 1072
participant stoichiometry: PARTICIPANT STOICHIOMETRY re636 1071
conversion direction: LEFT_TO_RIGHT
left: BAD
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: BAD
xref: STATE TRANSITION

GRIA
type: Protein
feature: GRIA GRIA s3525 sa2137 Active
cellular location: neuron c1

FZD s286 sa484 STOICHIOMETRY ID
type: Stoichiometry
physical entity: FZD s286 sa484
stoichiometric coefficient: 1.0

estrogen s907 sa630 STOICHIOMETRY ID
type: Stoichiometry
physical entity: estrogen
stoichiometric coefficient: 1.0

AP1 s2353 sa1834 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re149 233
type: Stoichiometry
physical entity: NR1H-24-OH-Chol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re149 232
type: Stoichiometry
physical entity: NR1H
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re149 231
type: Stoichiometry
physical entity: 24 OH Chol s521 sa202
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__ALLOP-RIGHT__ALLOP-_re329
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re329 510
participant stoichiometry: PARTICIPANT STOICHIOMETRY re329 511
conversion direction: LEFT_TO_RIGHT
left: ALLOP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ALLOP
xref: TRANSPORT

IL6
type: Protein
cellular location: neuron c1

TRANSPORT_LEFT__ALLOP-RIGHT__ALLOP-_re327
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re327 504
participant stoichiometry: PARTICIPANT STOICHIOMETRY re327 503
conversion direction: LEFT_TO_RIGHT
left: ALLOP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: ALLOP s2869 sa2274
xref: TRANSPORT

CASP12
type: Protein
cellular location: endoplasmic reticulum ER c5

STATE_TRANSITION_LEFT__LRP5_6-RIGHT__s2025-_re696
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re696 1123
participant stoichiometry: PARTICIPANT STOICHIOMETRY re696 1122
conversion direction: LEFT_TO_RIGHT
left: LRP5/6
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: s2025 s2025 sa1545
xref: STATE TRANSITION

TCF
type: Protein

HMGCRI
type: Protein
cellular location: neuron c1

APP s1736 sa1116 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP s1736 sa1116
stoichiometric coefficient: 3.0

metal ligand s1392 sa1061 STOICHIOMETRY ID
type: Stoichiometry
physical entity: metal ligand
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__NFKB1-RIGHT__NFKB1-_re553
type: TransportWithBiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re553 936
participant stoichiometry: PARTICIPANT STOICHIOMETRY re553 937
conversion direction: LEFT_TO_RIGHT
left: NFKB1 s1586 sa1221
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSPORT
right: NFKB1 s1589 sa1224
xref: TRANSPORT

activate microglia inflammatory processes
type: Pathway

PARTICIPANT STOICHIOMETRY re764 1234
type: Stoichiometry
physical entity: ATG7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re764 1235
type: Stoichiometry
physical entity: GABARAPL2
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__IL1B-RIGHT__IL1B-_re1280
type: TemplateReaction
participant: IL1B s3800 sa2712
participant: IL1B s3799 sa2711
product: IL1B s3800 sa2712
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

STOICHIOMETRY ID s932 csa88
type: Stoichiometry
physical entity: microtubules
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re764 1236
type: Stoichiometry
physical entity: GABARAPL2-ATG7
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__peroxynitrite__ONOO__-RIGHT__Lipid_peroxidation-_re55
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Lipid peroxidation
controller: peroxynitrite (ONOO-)

unknown protein s3761 sa2671 STOICHIOMETRY ID
type: Stoichiometry
physical entity: unknown protein s3761 sa2671
stoichiometric coefficient: 1.0

superoxide s2357 sa1840 STOICHIOMETRY ID
type: Stoichiometry
physical entity: superoxide s2357 sa1840
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1318 2099
type: Stoichiometry
physical entity: APOE LRP s3860 csa316
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1318 2098
type: Stoichiometry
physical entity: LRP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1318 2097
type: Stoichiometry
physical entity: APOE s607 sa177
stoichiometric coefficient: 1.0

NGFR s1169 sa859 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NGFR s1169 sa859
stoichiometric coefficient: 1.0

PTP
type: Protein
cellular location: neuron c1

AGEs
type: SmallMolecule

PARTICIPANT STOICHIOMETRY re1201 1887
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CASP2-RIGHT__Mitochondrial_dysfunction-_re1004
type: Control
xref: STATE TRANSITION
controlled: Mitochondrial dysfunction s462 sa81
controller: CASP2

PARTICIPANT STOICHIOMETRY re1201 1888
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

GSK3B
type: Protein
feature: GSK3B GSK3B s909 sa87 Active
feature: GSK3B GSK3B s909 sa87 rs1
cellular location: neuron c1

JAK2 s3454 sa1522 STOICHIOMETRY ID
type: Stoichiometry
physical entity: JAK2
stoichiometric coefficient: 1.0

MAP2K1 s2136 sa1650 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP2K1 s2136 sa1650
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__WNT-_SFRP-RIGHT__SFRP_WNT-_re699
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re699 1131
participant stoichiometry: PARTICIPANT STOICHIOMETRY re699 1132
participant stoichiometry: PARTICIPANT STOICHIOMETRY re699 1130
conversion direction: LEFT_TO_RIGHT
left: WNT
left: SFRP
interaction type: HETERODIMER_ASSOCIATION
right: SFRP-WNT
spontaneous: true
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__GTP-RIGHT__cGMP-_re390
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re390 641
participant stoichiometry: PARTICIPANT STOICHIOMETRY re390 642
conversion direction: LEFT_TO_RIGHT
left: GTP s1180 sa871
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: cGMP
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__APOE-_LRP-RIGHT__APOE_LRP-_re1318
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1318 2099
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1318 2098
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1318 2097
conversion direction: LEFT_TO_RIGHT
left: LRP
left: APOE s607 sa177
interaction type: HETERODIMER_ASSOCIATION
right: APOE LRP s3860 csa316
spontaneous: true
xref: HETERODIMER ASSOCIATION

KNOWN_TRANSITION_OMITTED_LEFT__LOO-RIGHT__lipid_radical_cycles-_re821
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: lipid-radical cycles
controller: LOO

STOICHIOMETRY ID s364 csa19
type: Stoichiometry
physical entity: MAC: membrane attack complex
stoichiometric coefficient: 1.0

GPCR
type: Protein
feature: GPCR GPCR s2119 sa1635 Active
cellular location: neuron c1

STOICHIOMETRY ID s826 csa75
type: Stoichiometry
physical entity: E3 ubiquitin-ligase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re220 314
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re220 315
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CTNNB1-RIGHT__sa64_degraded-_re694
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re694 1116
participant stoichiometry: PARTICIPANT STOICHIOMETRY re694 1115
conversion direction: LEFT_TO_RIGHT
left: CTNNB1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sa64 degraded s768 sa1543
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__UB_Unknown-RIGHT__sa585_degraded-_re691
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re691 1109
participant stoichiometry: PARTICIPANT STOICHIOMETRY re691 1110
conversion direction: LEFT_TO_RIGHT
left: UB-Unknown
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sa585_degraded
xref: STATE TRANSITION

viral defence
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__MAPT-RIGHT__MAPT_-_re730
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re730 1182
participant stoichiometry: PARTICIPANT STOICHIOMETRY re730 1181
conversion direction: LEFT_TO_RIGHT
left: MAPT
interaction type: KNOWN_TRANSITION_OMITTED
right: MAPT s3448 sa85
xref: KNOWN TRANSITION OMITTED

STATE_TRANSITION_LEFT__IRF-RIGHT__IRF-_re1227
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1227 1943
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1227 1942
conversion direction: LEFT_TO_RIGHT
left: IRF
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IRF
xref: STATE TRANSITION

cytokines
type: Pathway

SMPD2 s1510 sa1154 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SMPD2 s1510 sa1154
stoichiometric coefficient: 1.0

TRANSCRIPTION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__NFKBI-RIGHT__s2754-_re654
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re654 1092
participant stoichiometry: PARTICIPANT STOICHIOMETRY re654 1093
conversion direction: LEFT_TO_RIGHT
left: NFKBI
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: s2754
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__HMGCR-RIGHT__HMGCR-_re862
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re862 1407
participant stoichiometry: PARTICIPANT STOICHIOMETRY re862 1406
conversion direction: LEFT_TO_RIGHT
left: HMGCR
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: HMGCR
xref: STATE TRANSITION

CD3Z complex
type: Complex
component: CD3G
component: CD3E s2457 sa1921
component: CD3D s2456 sa1920
component: CD247

STOICHIOMETRY ID s3324 csa17
type: Stoichiometry
physical entity: APPBP1 APP s3324 csa17
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3299 csa172
type: Stoichiometry
physical entity: APOE-SDC2-Lipoprotein remnant
stoichiometric coefficient: 1.0

CTNNB1
type: Protein
feature: CTNNB1 CTNNB1 s2024 sa1541 rs2
feature: CTNNB1 CTNNB1 s2024 sa1541 rs1
cellular location: neuron c1

DNA damage
type: Pathway

APBB1-AICD
type: Complex
component: APBB1
component: AICD
cellular location: nucleus c3

PDH
type: DnaRegion
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re596 1001
type: Stoichiometry
physical entity: APC-AXIN-GSK3B-CTNNB1
stoichiometric coefficient: 1.0

EGFR s1411 sa1070 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

NFKBI s3473 sa1463 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NFKBI
stoichiometric coefficient: 1.0

ALOX
type: Protein
feature: ALOX ALOX s2693 sa2167 Active
cellular location: neuron c1

sa585_degraded
type: PhysicalEntity
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__ATG7-_GABARAPL2-RIGHT__GABARAPL2_ATG7-_re764
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re764 1234
participant stoichiometry: PARTICIPANT STOICHIOMETRY re764 1235
participant stoichiometry: PARTICIPANT STOICHIOMETRY re764 1236
conversion direction: LEFT_TO_RIGHT
left: ATG7
left: GABARAPL2
interaction type: HETERODIMER_ASSOCIATION
right: GABARAPL2-ATG7
spontaneous: true
xref: HETERODIMER ASSOCIATION

GTPase-GDI
type: Complex
component: GDI
component: GTPase
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re1069 1684
type: Stoichiometry
physical entity: KCNIP3-mutant PSEN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1069 1683
type: Stoichiometry
physical entity: KCNIP3
stoichiometric coefficient: 1.0

RAF1 s2145 sa1657 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1069 1682
type: Stoichiometry
physical entity: mutant PSEN
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AmyloidB-RIGHT__sa2546_degraded-_re1209
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1209 1904
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1209 1905
conversion direction: LEFT_TO_RIGHT
left: AmyloidB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sa2546_degraded
xref: STATE TRANSITION

IDE
type: Protein
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__MAPT_-RIGHT__synaptic_plasticity-_re733
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: synaptic plasticity
controller: MAPT s3448 sa85

PARTICIPANT STOICHIOMETRY re980 1615
type: Stoichiometry
physical entity: STXBP1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FYN-RIGHT__FYN-_re682
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re682 1105
participant stoichiometry: PARTICIPANT STOICHIOMETRY re682 1104
conversion direction: LEFT_TO_RIGHT
left: FYN s3455 sa1523
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FYN s3455 sa1524
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_re847
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re847 1380
participant stoichiometry: PARTICIPANT STOICHIOMETRY re847 1379
conversion direction: LEFT_TO_RIGHT
left: NFAT s2437 sa1911
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NFAT s2437 sa1912
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re980 1614
type: Stoichiometry
physical entity: STXBP1
stoichiometric coefficient: 1.0

C2 s1116 sa819 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C2
stoichiometric coefficient: 1.0

PS exposure
type: Pathway

STATE_TRANSITION_LEFT__ATG12_ATG10-_ATG5-RIGHT__ATG12_ATG6-_ATG10-_re758
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re758 1222
participant stoichiometry: PARTICIPANT STOICHIOMETRY re758 1225
participant stoichiometry: PARTICIPANT STOICHIOMETRY re758 1224
participant stoichiometry: PARTICIPANT STOICHIOMETRY re758 1223
conversion direction: LEFT_TO_RIGHT
left: ATG5
left: ATG12-ATG10
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: ATG12-ATG6
right: ATG10
xref: STATE TRANSITION

NTRK1
type: Protein
feature: NTRK1 NTRK1 s2325 sa1793 rs2
feature: NTRK1 NTRK1 s2325 sa1793 rs1
feature: NTRK1 NTRK1 s2325 sa1793 Active

ATG10 s2194 sa1699 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG10
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PRKAA2-RIGHT__PRKAA2-_re896
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re896 1474
participant stoichiometry: PARTICIPANT STOICHIOMETRY re896 1475
conversion direction: LEFT_TO_RIGHT
left: PRKAA2
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PRKAA2
xref: STATE TRANSITION

HSD17B10
type: Protein
cellular location: mitochondria c7

1-Met
type: SmallMolecule
cellular location: neuron c1

STOICHIOMETRY ID s3219 csa122
type: Stoichiometry
physical entity: C1Q-AmyloidB1-42-C3B
stoichiometric coefficient: 1.0

HDAC
type: Protein
cellular location: nucleus c3

UB s884 sa604 STOICHIOMETRY ID
type: Stoichiometry
physical entity: UB
stoichiometric coefficient: 2.0

MTHFR s1517 sa1162 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MTHFR s1517 sa1162
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CASP2-RIGHT__CASP2-_re1003
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1003 1632
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1003 1633
conversion direction: LEFT_TO_RIGHT
left: CASP2 s1761 sa1302
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CASP2
xref: STATE TRANSITION

STATE_TRANSITION_LEFT__APP_-RIGHT__N_APP-_re1194
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1194 1879
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1194 1880
conversion direction: LEFT_TO_RIGHT
left: APP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: N APP s3656 sa2571
xref: STATE TRANSITION

GLP1 s3927 sa2846 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GLP1 s3927 sa2846
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1326 2124
type: Stoichiometry
physical entity: Insulin-IR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AmyloidB-RIGHT__sa2703_degraded-_re1276
type: Degradation
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1276 2017
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1276 2018
conversion direction: LEFT_TO_RIGHT
left: AmyloidB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: sa2703 degraded s3792 sa2704
xref: STATE TRANSITION

LAG3 s2554 sa2017 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LAG3
stoichiometric coefficient: 2.0

N-APP
type: Protein
cellular location: default

KNOWN_TRANSITION_OMITTED_LEFT__IRF-RIGHT__cell_surviving_response-_re1231
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: cell surviving response
controller: IRF

CASP1 s1892 sa1414 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP1
stoichiometric coefficient: 1.0

MAT1A
type: Protein
cellular location: neuron c1

STOICHIOMETRY ID s3602 csa287
type: Stoichiometry
physical entity: LRP1-APOE
stoichiometric coefficient: 1.0

APOE-LPL-LIPC-Lipoprotein remnant
type: Complex
component: LPL
component: LIPC
component: Lipoprotein remnant
component: APOE s470 sa315
cellular location: sinusoid c28

STOICHIOMETRY ID s3194 csa107
type: Stoichiometry
physical entity: AmyloidB ALB s3194 csa107
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re987 1626
type: Stoichiometry
physical entity: Unknown TF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re987 1625
type: Stoichiometry
physical entity: Unknown TF
stoichiometric coefficient: 1.0

PRNP
type: Protein
feature: PRNP PRNP s510 sa386 Active

HETERODIMER_ASSOCIATION_LEFT__PSEN-RIGHT__CTNNB1_GSK3B_PRKA_PSEN-_re1075
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1075 1693
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1075 1692
conversion direction: LEFT_TO_RIGHT
left: PSEN
interaction type: HETERODIMER_ASSOCIATION
right: CTNNB1-GSK3B-PRKA-PSEN
spontaneous: true
xref: HETERODIMER ASSOCIATION

NLRs s3720 sa2629 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NLRs
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3860 csa316
type: Stoichiometry
physical entity: APOE LRP s3860 csa316
stoichiometric coefficient: 1.0

MAP2K4 s1902 sa1424 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAP2K4
stoichiometric coefficient: 1.0

60S s1500 sa1151 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 60S
stoichiometric coefficient: 2.0

KNOWN_TRANSITION_OMITTED_LEFT__TLR4_DAMPs-RIGHT__Apoptosis-_re1260
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Apoptosis
controller: TLR4-DAMPs

NT s1542 sa1188 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NT s1542 sa1188
stoichiometric coefficient: 1.0

CD3E s2464 sa2371 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD3E
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re419 699
type: Stoichiometry
physical entity: PRKG1-cGMP
stoichiometric coefficient: 1.0

APC s763 sa475 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re419 697
type: Stoichiometry
physical entity: PRKG1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re419 698
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re864 1412
type: Stoichiometry
physical entity: FDPS s1098 sa1949
stoichiometric coefficient: 1.0

BACE1
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re864 1413
type: Stoichiometry
physical entity: FDPS
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__microtubules-RIGHT__TUB-_re291
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re291 450
participant stoichiometry: PARTICIPANT STOICHIOMETRY re291 449
conversion direction: LEFT_TO_RIGHT
left: microtubules
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TUB
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re15 13
type: Stoichiometry
physical entity: BID
stoichiometric coefficient: 1.0

16,17S-DHA Epoxide
type: SmallMolecule
cellular location: neuron c1

TRAF2 s1928 sa1459 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TRAF2
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re451 740
type: Stoichiometry
physical entity: hypotaurine
stoichiometric coefficient: 1.0

COX s3585 sa2493 STOICHIOMETRY ID
type: Stoichiometry
physical entity: COX s3585 sa2493
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 12
type: Stoichiometry
physical entity: BID
stoichiometric coefficient: 1.0

APP-APBB1
type: Complex
component: APBB1
component: APP
cellular location: neuron c1

STATE_TRANSITION_LEFT__TUB-RIGHT__TUB-_re290
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re290 446
participant stoichiometry: PARTICIPANT STOICHIOMETRY re290 445
conversion direction: LEFT_TO_RIGHT
left: TUB
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TUB s929 sa648
xref: STATE TRANSITION

EIF2AK3 s2466 sa1930 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 4.0

S100 calgranulin s3813 sa2723 STOICHIOMETRY ID
type: Stoichiometry
physical entity: S100/calgranulin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1300 2061
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

GTPase s3530 sa1567 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GTPase s3530 sa1567
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1300 2060
type: Stoichiometry
physical entity: s3841
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__SET-_APBB1_AICD-_KAT5-RIGHT__APBB1_KAT5_SET_AICD-_re310
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re310 473
participant stoichiometry: PARTICIPANT STOICHIOMETRY re310 474
participant stoichiometry: PARTICIPANT STOICHIOMETRY re310 471
participant stoichiometry: PARTICIPANT STOICHIOMETRY re310 472
conversion direction: LEFT_TO_RIGHT
left: SET s1001 sa711
left: KAT5
left: APBB1-AICD
interaction type: HETERODIMER_ASSOCIATION
right: APBB1-KAT5-SET-AICD
spontaneous: true
xref: HETERODIMER ASSOCIATION

GSK3B
type: Protein
feature: GSK3B GSK3B s1431 sa1093 Active

HETERODIMER_ASSOCIATION_LEFT__AmyloidB-_TTR-RIGHT__AmyloidB_TTR-_re376
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re376 625
participant stoichiometry: PARTICIPANT STOICHIOMETRY re376 627
participant stoichiometry: PARTICIPANT STOICHIOMETRY re376 626
conversion direction: LEFT_TO_RIGHT
left: TTR
left: AmyloidB
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB-TTR
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re451 741
type: Stoichiometry
physical entity: taurine
stoichiometric coefficient: 1.0

TSC s3458 sa2051 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TSC
stoichiometric coefficient: 1.0

glutamate
type: SmallMolecule
cellular location: synaptic vesicle c14

FNTA
type: Protein
cellular location: neuron c1

phospholipase A2 s3681 sa2595 STOICHIOMETRY ID
type: Stoichiometry
physical entity: phospholipase A2 s3681 sa2595
stoichiometric coefficient: 1.0

CASP8
type: Protein

INPP5K-CSHL1-HDAC-NCOR2
type: Complex
component: CSHL1
component: INPP5K
component: HDAC s10 sa2026
component: NCOR2
cellular location: nucleus c3

NPC s513 sa187 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NPC s513 sa187
stoichiometric coefficient: 1.0

WIF1 s2035 sa1551 STOICHIOMETRY ID
type: Stoichiometry
physical entity: WIF1 s2035 sa1551
stoichiometric coefficient: 1.0

IL6 s3623 sa2526 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL6
stoichiometric coefficient: 1.0

ENAH s1649 sa1268 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ENAH s1649 sa1268
stoichiometric coefficient: 1.0

ATG17
type: Protein
cellular location: neuron c1

GUCY1
type: Protein
cellular location: presynaptic terminal c11

STOICHIOMETRY ID s3266 csa1
type: Stoichiometry
physical entity: CALM-Ca2+
stoichiometric coefficient: 1.0

APC-GSK3B-AXIN-CTNNB1
type: Complex
component: CTNNB1
component: GSK3B s2878 sa2286
component: APC
component: AXIN
cellular location: neuron c1

STATE_TRANSITION_LEFT__IPP-RIGHT__DMAPP-_re345
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re345 553
participant stoichiometry: PARTICIPANT STOICHIOMETRY re345 552
conversion direction: LEFT_TO_RIGHT
left: IPP
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: DMAPP
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re458 757
type: Stoichiometry
physical entity: HS-
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re458 758
type: Stoichiometry
physical entity: L-Cystine
stoichiometric coefficient: 1.0

some ions
type: PhysicalEntity
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re458 755
type: Stoichiometry
physical entity: L-Cys
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re458 756
type: Stoichiometry
physical entity: thiocysteine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Unknown_TF-RIGHT__Unknown_TF-_re987
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re987 1626
participant stoichiometry: PARTICIPANT STOICHIOMETRY re987 1625
conversion direction: LEFT_TO_RIGHT
left: Unknown TF
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Unknown TF
xref: STATE TRANSITION

homo Cys s1519 sa1164 STOICHIOMETRY ID
type: Stoichiometry
physical entity: homo-Cys
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: mitochondria c7

re353 s2382 sa1868 569
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Squalene-RIGHT__Oxydosqualene-_re353
control type: INHIBITION
controller: OSC inhibitor

PARTICIPANT STOICHIOMETRY re97 166
type: Stoichiometry
physical entity: CD93-C1Q-AmyloidB1-42
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re97 165
type: Stoichiometry
physical entity: AmyloidB1-42-C1Q
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__TUB-RIGHT__TUB-_re288
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re288 439
participant stoichiometry: PARTICIPANT STOICHIOMETRY re288 438
conversion direction: LEFT_TO_RIGHT
left: TUB s929 sa648
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: TUB
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re97 164
type: Stoichiometry
physical entity: CD93
stoichiometric coefficient: 1.0

CTNNB1
type: Protein
feature: CTNNB1 CTNNB1 s766 sa478 rs2

PARTICIPANT STOICHIOMETRY re522 867
type: Stoichiometry
physical entity: SMPD2
stoichiometric coefficient: 1.0

CD93
type: Protein
cellular location: microglia c4

C83 s6 sa34 STOICHIOMETRY ID
type: Stoichiometry
physical entity: C83
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re522 866
type: Stoichiometry
physical entity: SMPD2 s1510 sa1154
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__C3-RIGHT__C3-_re435
type: TemplateReaction
participant: C3 s1301 sa963
participant: C3
product: C3
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

PPARG s2407 sa1762 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARG
stoichiometric coefficient: 2.0

PPARG ligand s3673 sa2586 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PPARG ligand
stoichiometric coefficient: 2.0

FTI
type: SmallMolecule
cellular location: neuron c1

CAPN2
type: Protein

IPAF s3725 sa2637 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IPAF
stoichiometric coefficient: 1.0

sphingoshine1 P s3946 sa2864 STOICHIOMETRY ID
type: Stoichiometry
physical entity: sphingoshine1-P
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3500 csa146
type: Stoichiometry
physical entity: LRP1-AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re541 915
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

EDN1
type: DnaRegion
cellular location: nucleus c3

PARTICIPANT STOICHIOMETRY re541 914
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

BACE1
type: RnaRegion
cellular location: neuron c1

cytokines s3699 sa2612 STOICHIOMETRY ID
type: Stoichiometry
physical entity: cytokines
stoichiometric coefficient: 1.0

KCNIP3
type: Protein

GAPDH s2818 sa2257 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GAPDH
stoichiometric coefficient: 1.0

APOE-AmyloidB
type: Complex
component: AmyloidB
component: APOE s470 sa315
cellular location: Brain c26

NO s3512 sa917 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

15-LOX-1
type: Protein
cellular location: neuron c1

STOICHIOMETRY ID s3325 csa256
type: Stoichiometry
physical entity: APP APBB1 ABL s3325 csa256
stoichiometric coefficient: 1.0

AmyloidB1 42 s1280 sa944 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB1 42 s1280 sa944
stoichiometric coefficient: 5.0

MT ND s186 sa280 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MT-ND
stoichiometric coefficient: 1.0

NO s1245 sa915 STOICHIOMETRY ID
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__IL1B-RIGHT__IL1B-_re512
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re512 839
participant stoichiometry: PARTICIPANT STOICHIOMETRY re512 838
conversion direction: LEFT_TO_RIGHT
left: IL1B
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IL1B s1310 sa1115
xref: STATE TRANSITION

AMP s891 sa614 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

CTNNB1
type: Protein
cellular location: neuron c1

STOICHIOMETRY ID s3309 csa271
type: Stoichiometry
physical entity: GRIA-glutamate
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__CASP8-RIGHT__Mitochondrial_dysfunction-_re587
type: Control
xref: UNKNOWN TRANSITION
controlled: Mitochondrial dysfunction s462 sa81
controller: CASP8

PARTICIPANT STOICHIOMETRY re591 981
type: Stoichiometry
physical entity: oxidative stress
stoichiometric coefficient: 1.0

KCN s2646 sa2106 STOICHIOMETRY ID
type: Stoichiometry
physical entity: KCN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re591 983
type: Stoichiometry
physical entity: GPCR-oxidative stress
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re591 982
type: Stoichiometry
physical entity: GPCR homolog
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__APP_PCBP2_PCBP1_FMR1_60S_40S-RIGHT__40S-_FMR1-_PCBP2-_APP-_PCBP1-_re442
type: TemplateReaction
participant: PCBP2
participant: 40S
participant: FMR1 s1464 sa1121
participant: APP
participant: APP PCBP2 PCBP1 FMR1 60S 40S s3232 csa135
participant: PCBP1
product: PCBP2
product: 40S
product: FMR1 s1464 sa1121
product: APP
product: PCBP1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

Unknown TF
type: Protein
feature: Unknown TF Unknown TF s3467 sa2313 Active
cellular location: neuron c1

CIB1
type: Protein

MAPK8 s1911 sa830 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MAPK8
stoichiometric coefficient: 1.0

MAPK13
type: Protein
feature: MAPK13 MAPK13 s1803 sa1341 Active
feature: MAPK13 MAPK13 s1803 sa1341 rs1
cellular location: MAPK cascade c6

LOX s3586 sa2494 STOICHIOMETRY ID
type: Stoichiometry
physical entity: LOX
stoichiometric coefficient: 1.0

TH
type: Protein
cellular location: neuron c1

oxyradical
type: SmallMolecule
cellular location: neuron c1

CAT
type: Protein
cellular location: neuron c1

microglia c4
type: CellularLocationVocabulary
comment: _microglia

USP17L2 s935 sa656 STOICHIOMETRY ID
type: Stoichiometry
physical entity: USP17L2
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__VLDLR-_APOE-RIGHT__VLDLR_APOE-_re723
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re723 1169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re723 1168
participant stoichiometry: PARTICIPANT STOICHIOMETRY re723 1170
conversion direction: LEFT_TO_RIGHT
left: APOE s607 sa177
left: VLDLR s2093 sa1615
interaction type: HETERODIMER_ASSOCIATION
right: VLDLR-APOE
spontaneous: true
xref: HETERODIMER ASSOCIATION

NCOR2
type: Protein
cellular location: nucleus c3

glutamate-GRIN
type: Complex
component: GRIN s1992 sa886
component: glutamate s1206 sa1497
cellular location: postsynaptic density c12

GTPase
type: Protein
feature: GTPase GTPase s2865 sa2270 rs1
cellular location: neuron c1

ROS
type: SmallMolecule
cellular location: microglia c4

TLR2-DAMPs
type: Complex
component: TLR2
component: DAMPs s3733 sa2647
cellular location: neuron c1

STATE_TRANSITION_LEFT__s3840-RIGHT__CEX1-_re1299
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1299 2057
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1299 2058
conversion direction: LEFT_TO_RIGHT
left: s3840 s3840 sa2749
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: CEX1
xref: STATE TRANSITION

APP s1535 sa1182 STOICHIOMETRY ID
type: Stoichiometry
physical entity: APP s1535 sa1182
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re615 1035
type: Stoichiometry
physical entity: LIPC s1849 sa1380
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re615 1034
type: Stoichiometry
physical entity: APOE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re615 1033
type: Stoichiometry
physical entity: Lipoprotein remnant
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re615 1032
type: Stoichiometry
physical entity: LPL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re615 1036
type: Stoichiometry
physical entity: APOE-LPL-LIPC-Lipoprotein remnant
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3278 csa215
type: Stoichiometry
physical entity: NGFR NTF4 s3278 csa215
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s2858 csa227
type: Stoichiometry
physical entity: CD3Z complex
stoichiometric coefficient: 1.0

CDK4 6 s921 sa641 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDK4 6 s921 sa641
stoichiometric coefficient: 1.0

DCTN5
type: Protein

SMPD2 s1514 sa1159 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SMPD2
stoichiometric coefficient: 1.0

Choline
type: SmallMolecule
cellular location: neuron c1

complement system
type: Pathway

TRADD
type: Protein

VPS26A
type: Protein

Unknown TF
type: Protein
cellular location: neuron c1

APH1
type: Protein

PRIM-APEX1-POLD1-replication origin
type: Complex
component: POLD1
component: PRIM1
component: replication origin
component: APEX1 s1678 sa406
cellular location: DNAreplification c9

KNOWN_TRANSITION_OMITTED_LEFT__AmyloidB_CLU-RIGHT__Unknown_transportation-_re1027
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Unknown transportation
controller: AmyloidB CLU s3244 csa263

acetoacetate
type: SmallMolecule
cellular location: neuron c1

AKT1 s2090 sa1607 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 2.0

FPRL1
type: DnaRegion
cellular location: microglia c4

IL4
type: Protein
cellular location: microglia c4

Neuro-toxicity
type: Pathway

TRANSLATION_LEFT__cytokine-RIGHT__cytokine-_re1254
type: TemplateReaction
participant: cytokine
participant: cytokine s3764 sa2674
product: cytokine s3764 sa2674
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

PEBP1
type: Protein
feature: PEBP1 PEBP1 s2139 sa1653 rs1
cellular location: neuron c1

O2 s1356 sa1022 STOICHIOMETRY ID
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

re1298 s3827 sa2736 2053
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__s3839-RIGHT__B94-_re1298
control type: INHIBITION
controller: NPD1

STATE_TRANSITION_LEFT__TNFA-RIGHT__activate_astrocyte-_re1183
type: Control
xref: STATE TRANSITION
controlled: activate astrocyte
controller: TNFA s3630 sa2534

EGFR s1415 sa1072 STOICHIOMETRY ID
type: Stoichiometry
physical entity: EGFR s1415 sa1072
stoichiometric coefficient: 1.0

SRA2
type: Protein

TFR s2619 sa2086 STOICHIOMETRY ID
type: Stoichiometry
physical entity: TFR
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3351 csa23
type: Stoichiometry
physical entity: APOE-LPL
stoichiometric coefficient: 1.0

CDC42 s2394 sa1880 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDC42
stoichiometric coefficient: 1.0

AICD s985 sa693 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 4.0

STATE_TRANSITION_LEFT__IL6-RIGHT__IL6-_re1201
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1201 1887
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1201 1888
conversion direction: LEFT_TO_RIGHT
left: IL6
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: IL6
xref: STATE TRANSITION

AmyloidB-NMDAR
type: Complex
component: AmyloidB
component: NMDAR
cellular location: neuron c1

AmyloidB clearance
type: Pathway

S100/calgranulin
type: Protein
cellular location: default

PARTICIPANT STOICHIOMETRY re558 940
type: Stoichiometry
physical entity: AmyloidB s1546 sa1194
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Farnesyl_PP-RIGHT__Heme_A-_re350
type: Conversion
participant stoichiometry: PARTICIPANT STOICHIOMETRY re350 565
participant stoichiometry: PARTICIPANT STOICHIOMETRY re350 566
conversion direction: LEFT_TO_RIGHT
left: Farnesyl PP
interaction type: KNOWN_TRANSITION_OMITTED
right: Heme A s1104 sa808
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re558 941
type: Stoichiometry
physical entity: s1594
stoichiometric coefficient: 1.0

Ubiquinone s3015 sa2367 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Ubiquinone
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__APC_AXIN_GSK3B_CTNNB1-RIGHT__APC-_re259
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re259 379
participant stoichiometry: PARTICIPANT STOICHIOMETRY re259 378
conversion direction: LEFT_TO_RIGHT
left: APC-AXIN-GSK3B-CTNNB1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: APC
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__HSD17B10-_Oligomeric_AmyloidB-RIGHT__Oligomeric_AmyloidB_HSD17B10-_re1034
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1034 1644
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1034 1643
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1034 1642
conversion direction: LEFT_TO_RIGHT
left: Oligomeric AmyloidB
left: HSD17B10
interaction type: HETERODIMER_ASSOCIATION
right: Oligomeric AmyloidB-HSD17B10
spontaneous: true
xref: HETERODIMER ASSOCIATION

STATE_TRANSITION_LEFT__GDI-RIGHT__GDI-_re867
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re867 1416
participant stoichiometry: PARTICIPANT STOICHIOMETRY re867 1415
conversion direction: LEFT_TO_RIGHT
left: GDI
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: GDI
xref: STATE TRANSITION

GLUT s3907 sa2825 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GLUT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1160 1810
type: Stoichiometry
physical entity: TLR
stoichiometric coefficient: 1.0

GPCR homolog
type: Protein
cellular location: neuron c1

protein trafficking
type: Pathway

STATE_TRANSITION_LEFT__AKT1S1-RIGHT__AKT1S1-_re894
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re894 1471
participant stoichiometry: PARTICIPANT STOICHIOMETRY re894 1472
conversion direction: LEFT_TO_RIGHT
left: AKT1S1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: AKT1S1
xref: STATE TRANSITION

CD4 s2440 sa1915 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CD4
stoichiometric coefficient: 1.0

MAC
type: Protein
cellular location: default

SRC s1401 sa1066 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re408 682
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

CHRN s2663 sa2121 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CHRN
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AA_production-RIGHT__AA-_re1129
type: Interaction
participant: AA
participant: AA production
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re1160 1808
type: Stoichiometry
physical entity: TLR-AmyloidB
stoichiometric coefficient: 1.0

SRA2
type: Protein
cellular location: microglia c4

ATP s1240 sa910 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

MVK
type: Protein
cellular location: neuron c1

PARTICIPANT STOICHIOMETRY re408 681
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

FAS
type: Protein
cellular location: neuron c1

HETERODIMER_ASSOCIATION_LEFT__GRIA-_glutamate-RIGHT__GRIA_glutamate-_re1057
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1057 1662
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1057 1660
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1057 1661
conversion direction: LEFT_TO_RIGHT
left: GRIA
left: glutamate
interaction type: HETERODIMER_ASSOCIATION
right: GRIA-glutamate
spontaneous: true
xref: HETERODIMER ASSOCIATION

PARTICIPANT STOICHIOMETRY re916 1520
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Inflammatory signaling
type: Pathway

PARTICIPANT STOICHIOMETRY re916 1521
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

AmyloidB s1137 sa837 STOICHIOMETRY ID
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 5.0

PARTICIPANT STOICHIOMETRY re405 677
type: Stoichiometry
physical entity: cAMP s1239 sa909
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1160 1809
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re405 676
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

RAC
type: Protein
feature: RAC RAC s1904 sa1426 Active
feature: RAC RAC s1904 sa1426 rs1
cellular location: MAPK cascade c6

STATE_TRANSITION_LEFT__FPRL1-RIGHT__FPRL1-_re1210
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1210 1910
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1210 1909
conversion direction: LEFT_TO_RIGHT
left: FPRL1
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: FPRL1
xref: STATE TRANSITION

PARTICIPANT STOICHIOMETRY re282 435
type: Stoichiometry
physical entity: ADAM
stoichiometric coefficient: 1.0

ATG7 s2222 sa1722 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATG7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re282 434
type: Stoichiometry
physical entity: ADAM
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1320 2107
type: Stoichiometry
physical entity: TNFA
stoichiometric coefficient: 1.0

Delta s940 sa662 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Delta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1320 2106
type: Stoichiometry
physical entity: TNFA s3864 sa2783
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__ceramide-RIGHT__Mitochondrial_dysfunction-_re1151
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Mitochondrial dysfunction s3572 sa2480
controller: ceramide

NLRs
type: Protein
cellular location: microglia c4

SRA1
type: Protein

UB
type: Protein

IL4 s3671 sa2584 STOICHIOMETRY ID
type: Stoichiometry
physical entity: IL4 s3671 sa2584
stoichiometric coefficient: 1.0

CASP6 s93 sa213 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CASP6
stoichiometric coefficient: 1.0

5ADHP s2825 sa2259 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 5ADHP
stoichiometric coefficient: 2.0

PRKG1 s3463 sa2101 STOICHIOMETRY ID
type: Stoichiometry
physical entity: PRKG1
stoichiometric coefficient: 1.0

MSRB2 s1125 sa826 STOICHIOMETRY ID
type: Stoichiometry
physical entity: MSRB2 s1125 sa826
stoichiometric coefficient: 1.0

ATP s890 sa613 STOICHIOMETRY ID
type: Stoichiometry
physical entity: ATP s890 sa613
stoichiometric coefficient: 5.0

HETERODIMER_ASSOCIATION_LEFT__S100_calgranulin-_RAGE-RIGHT__RAGE_S100_calgranulin-_re1284
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1284 2030
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1284 2029
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1284 2028
conversion direction: LEFT_TO_RIGHT
left: RAGE
left: S100/calgranulin
interaction type: HETERODIMER_ASSOCIATION
right: RAGE-S100/calgranulin
spontaneous: true
xref: HETERODIMER ASSOCIATION

TRANSCRIPTION_LEFT__VCAM1-RIGHT__VCAM1-_re569
type: TemplateReaction
participant: VCAM1
product: VCAM1
interaction type: TRANSCRIPTION
xref: TRANSCRIPTION

GSK3B inhibitors s2062 sa1774 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GSK3B inhibitors
stoichiometric coefficient: 1.0

CCND1
type: DnaRegion
cellular location: nucleus c3

KNOWN_TRANSITION_OMITTED_LEFT__TLR8-RIGHT__Apoptosis-_re1258
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Apoptosis
controller: TLR8

CTNNB1-GSK3B-PRKA-PSEN
type: Complex
component: CTNNB1 s748 sa496
component: PRKA
component: PSEN
component: GSK3B
cellular location: endoplasmic reticulum ER c5

lipoxin A4 s3680 sa2594 STOICHIOMETRY ID
type: Stoichiometry
physical entity: lipoxin A4
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PLCG-RIGHT__PLCG-_re990
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re990 1631
participant stoichiometry: PARTICIPANT STOICHIOMETRY re990 1630
conversion direction: LEFT_TO_RIGHT
left: PLCG
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: PLCG
xref: STATE TRANSITION

O2 s3620 sa2520 STOICHIOMETRY ID
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 2.0

STOICHIOMETRY ID s3363 csa170
type: Stoichiometry
physical entity: APOE-SDC2-LIPC-LPL-Lipoprotein remnant
stoichiometric coefficient: 1.0

destruction of membranes
type: Pathway

NALP
type: Protein
feature: NALP NALP s3726 sa2639 Active
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re841 1367
type: Stoichiometry
physical entity: RAS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re841 1368
type: Stoichiometry
physical entity: Farnesyl PP
stoichiometric coefficient: 1.0

SUOX s1366 sa1032 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SUOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re841 1369
type: Stoichiometry
physical entity: RAS-Farnesyl PP
stoichiometric coefficient: 1.0

GRI s2689 sa2160 STOICHIOMETRY ID
type: Stoichiometry
physical entity: GRI
stoichiometric coefficient: 1.0

PIK3
type: Protein
cellular location: neuron c1

PE
type: SmallMolecule

STOICHIOMETRY ID s497 csa26
type: Stoichiometry
physical entity: endosome lysosome s497 csa26
stoichiometric coefficient: 1.0

glucose s3897 sa2816 STOICHIOMETRY ID
type: Stoichiometry
physical entity: glucose
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__TNF-_Unknown_receptor-RIGHT__unkown_receptor_TNF-_re920
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re920 1532
participant stoichiometry: PARTICIPANT STOICHIOMETRY re920 1533
participant stoichiometry: PARTICIPANT STOICHIOMETRY re920 1531
conversion direction: LEFT_TO_RIGHT
left: TNF
left: Unknown receptor
interaction type: HETERODIMER_ASSOCIATION
right: unkown receptor TNF s3288 csa249
spontaneous: true
xref: HETERODIMER ASSOCIATION

HSD17B10 s2983 sa80 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HSD17B10
stoichiometric coefficient: 1.0

PIK3
type: Protein
feature: PIK3 PIK3 s910 sa633 Active
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__NALP3-RIGHT__inflammation-_re1234
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: inflammation
controller: NALP3 s3721 sa2630

SCAR-AmyloidB fibril
type: Complex
component: AmyloidB fibril
component: SCAR
cellular location: microglia c4

L-Cystine
type: SmallMolecule
cellular location: neuron c1

KNOWN_TRANSITION_OMITTED_LEFT__dedifferentiation-RIGHT__G0-_re79
type: Interaction
participant: G0 s85 sa135
participant: dedifferentiation
xref: KNOWN TRANSITION OMITTED

PARTICIPANT STOICHIOMETRY re1276 2017
type: Stoichiometry
physical entity: AmyloidB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re808 1298
type: Stoichiometry
physical entity: SMPD s2348 sa1827
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1276 2018
type: Stoichiometry
physical entity: sa2703 degraded s3792 sa2704
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re808 1297
type: Stoichiometry
physical entity: SMPD
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3334 csa34
type: Stoichiometry
physical entity: PRIM-APEX1-POLD1-replication origin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re965 1584
type: Stoichiometry
physical entity: GSH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re965 1583
type: Stoichiometry
physical entity: GSSG
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3287 csa248
type: Stoichiometry
physical entity: unknown receptor-sAPPA
stoichiometric coefficient: 1.0

s225
type: Complex
component: APP
component: SORL1

SNX s256 sa369 STOICHIOMETRY ID
type: Stoichiometry
physical entity: SNX
stoichiometric coefficient: 4.0

ALB
type: Protein
cellular location: Blood c15

GAPDH
type: Protein
feature: GAPDH GAPDH s649 sa247 Active
cellular location: default

TF-Fe
type: Complex
component: Fe s1455 sa1110
component: TF
cellular location: default

PARTICIPANT STOICHIOMETRY re1257 1998
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1257 1999
type: Stoichiometry
physical entity: DAMPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re489 807
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re489 808
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__C3-RIGHT__C3A-_C3B-_re436
type: TemplateReaction
participant: C3B s3489 sa946
participant: C3A
participant: C3
product: C3B s3489 sa946
product: C3A
interaction type: CELLDESIGNER INTERACTION VOCABULARY=TRANSLATION
xref: TRANSLATION

STOICHIOMETRY ID s3816 csa314
type: Stoichiometry
physical entity: AmyloidB1 42 FPRL1 s3816 csa314
stoichiometric coefficient: 1.0

PFK
type: Protein
feature: PFK PFK s3487 sa243 Active
cellular location: default

PARTICIPANT STOICHIOMETRY re333 524
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re333 525
type: Stoichiometry
physical entity: ALLOP
stoichiometric coefficient: 1.0

RYR3 s3145 sa1891 STOICHIOMETRY ID
type: Stoichiometry
physical entity: RYR3 s3145 sa1891
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__not_written-RIGHT__NO-_re1157
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1157 1800
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1157 1801
conversion direction: LEFT_TO_RIGHT
left: not written
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: NO
xref: STATE TRANSITION

HETERODIMER_ASSOCIATION_LEFT__A2M-_AmyloidB-RIGHT__AmyloidB_A2M-_re1098
type: ComplexAssembly
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1098 1736
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1098 1735
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1098 1737
conversion direction: LEFT_TO_RIGHT
left: A2M
left: AmyloidB s1546 sa1194
interaction type: HETERODIMER_ASSOCIATION
right: AmyloidB-A2M
spontaneous: true
xref: HETERODIMER ASSOCIATION

CALM
type: Protein
cellular location: neuron c1

POLB
type: Protein

HMGB1 s3811 sa2721 STOICHIOMETRY ID
type: Stoichiometry
physical entity: HMGB1 s3811 sa2721
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1177 1860
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1177 1859
type: Stoichiometry
physical entity: not written
stoichiometric coefficient: 1.0

BACE s1558 sa1201 STOICHIOMETRY ID
type: Stoichiometry
physical entity: BACE s1558 sa1201
stoichiometric coefficient: 1.0

50kDa fragment s3011 sa2364 STOICHIOMETRY ID
type: Stoichiometry
physical entity: 50kDa fragment
stoichiometric coefficient: 1.0

STOICHIOMETRY ID s3213 csa115
type: Stoichiometry
physical entity: glutamate-GR
stoichiometric coefficient: 1.0

Ca2 PLUS s131 sa83 STOICHIOMETRY ID
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__R_SH-_L_Cys-RIGHT__HS_-_Cys_S_R-_re454
type: BiochemicalReaction
participant stoichiometry: PARTICIPANT STOICHIOMETRY re454 748
participant stoichiometry: PARTICIPANT STOICHIOMETRY re454 749
participant stoichiometry: PARTICIPANT STOICHIOMETRY re454 746
participant stoichiometry: PARTICIPANT STOICHIOMETRY re454 747
conversion direction: LEFT_TO_RIGHT
left: L-Cys
left: R-SH
interaction type: CELLDESIGNER INTERACTION VOCABULARY=STATE TRANSITION
right: Cys-S-R
right: HS-
xref: STATE TRANSITION

SDC2
type: Protein
cellular location: sinusoid c28

CDK5 s138 sa325 STOICHIOMETRY ID
type: Stoichiometry
physical entity: CDK5 s138 sa325
stoichiometric coefficient: 1.0

iNOS
type: Protein
cellular location: microglia c4

PARTICIPANT STOICHIOMETRY re378 631
type: Stoichiometry
physical entity: AmyloidB TTR s3196 csa108
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re378 630
type: Stoichiometry
physical entity: AmyloidB-TTR
stoichiometric coefficient: 1.0