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["Description of the predictive genes "]
["Gene ID (Entrez) – the ID of each gene"]
["Gene Symbol – The symbol of each gene"]
["Name – the name of each gene"]
["Description – description of each gene"]
["GO – GO annotations related to each gene"]
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["Gene ID (Entrez)","Gene Symbol","Name","Description","GO"]
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[760,"CA2","carbonic anhydrase II","CA2 is one of several (at least 7) isozymes of carbonic anhydrase. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. "]
[1183,"CLCN4","chloride channel 4","The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders"]
[79659,"DNCH2","dynein, cytoplasmic, heavy polypeptide 2"]
[55689,"FLJ10201","YEATS domain containing 2"]
[79697,"FLJ21802","chromosome 14 open reading frame 169"]
[2358,"FPRL1","formyl peptide receptor-like 1 ","G-protein coupled receptor protein signaling pathway,\ncelladhesion, cell motility, chemotaxis, inflammatory response,\nsignal transduction"]
[10146,"G3BP","GTPase activating protein (SH3 domain) binding protein 1","This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.","ATP binding, ATP-dependent, DNA helicase activity, ATP-dependent\nRNA helicase activity, DNA binding, RNA binding, endonuclease\nactivity, helicase activity, hydrolase activity, nucleic acid\nbinding, nucleotide binding, protein binding"]
["---","Homo sapiens familial Mediterranean fever locus region, mRNA sequence","-----"]
[11009,"IL24","This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. "]
[23331,"KIAA1043","tetratricopeptide repeat domain 28"]
[51145,"LOC51145","erythrocyte transmembrane protein ","integral to membrane"]
[347733,"MGC8685","tubulin, beta 2B","microtubule-based movement, mitosis, neuron differentiation,\nprotein polymerization"]
[26577,"PCOLCE2","procollagen C-endopeptidase enhancer 2","heparin binding, protein binding"]
[5134,"PDCD2","programmed cell death 2","This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Two transcripts encoding different proteins have been identified.","apoptosis"]
[8500,"PPFIA1","protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1","The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.","cell-matrix adhesion, signal transduction"]
[57127,"RHBG","Rh family, B glycoprotein","RHBG and RHCG are non-erythroid members of the Rhesus (Rh) protein family that are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. Rh family proteins are all predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. ","ammonium transport, transport"]
[202559,"SLM1","KH domain containing, RNA binding, signal transduction associated 2",null,"regulation of transcription, DNA-dependent, transcription"]
[6594,"SMARCA1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1","This gene encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. ","ATP-dependent chromatin remodeling brain\ndevelopment, neuron differentiation,\n  positive regulation of\ngene-specific transcription, regulation of transcription,\nDNA-dependent, transcription"]
[6693,"SPN","sialophorin (leukosialin, CD43)","Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation","T cell costimulation, cell surface receptor, signal transduction,\ncellular defense response, chemotaxis, defense response to\nbacterium, establishment and/or maintenance of cell polarity,\ninduction of apoptosis by extracellular signals, negative\nregulation of T cell proliferation, negative regulation of cell\nadhesion, negative regulation of type IV hypersensitivity,\nnegative thymic T cell selection, positive regulation of T cell\nproliferation, positive regulation of tumor necrosis factor\nbiosynthetic process, regulation of defense response to virus,\nregulation of immune response, response to protozoan"]
[6875,"TAF4B","TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa","TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II ","regulation of transcription, DNA-dependent, transcription,\ntranscription initiation"]
[7042,"TGFB2","transforming growth factor, beta 2",null,"angiogenesis , axon guidance, blood vessel development, blood\nvessel remodeling, cardiac muscle cell proliferation, cardioblast\ndifferentiation, catagen, cell death, cell growth, cell\nmorphogenesis, cell proliferation , cell-cell signaling, dopamine\nbiosynthetic process, embryonic development, epithelial to\nmesenchymal transition, extracellular matrix organization and\nbiogenesis, eye development, generation of neurons, hair follicle\nmorphogenesis, hemopoiesis, negative regulation of epithelial cell\nproliferation, negative regulation of immune response, neuron\ndevelopment, neuron fate commitment, neutrophil chemotaxis,\nneutrophil chemotaxis, positive regulation of cardioblast\ndifferentiation, positive regulation of catagen, positive\nregulation of cell cycle, positive regulation of cell growth,\npositive regulation of cell proliferation, positive regulation of\nheart contraction, positive regulation of immune response,\npositive regulation of neuron apoptosis, regulation of apoptosis,\nregulation of transforming growth factor-beta2 production,\nresponse to hypoxia, skeletal development, somatic stem cell\ndivision, wound healing"]
[8626,"TP73L","tumor protein p63","This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. ","Notch signaling pathway, apoptosis, induction of apoptosis,\nmulticellular organismal development, negative regulation of cell\ngrowth, negative regulation of transcription, DNA-dependent,\npositive regulation of Notch signaling pathway, positive\nregulation of transcription, DNA-dependent, protein\nhomotetramerization, response to tumor cell\n"]
[10346,"TRIM22","tite motif-containing 22","The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects","immune response, regulation of transcription, DNA-dependent,\nresponse to virus"]