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["© 2000-2014 Ingenuity Systems, Inc. All rights reserved."]
["Ingenuity Canonical Pathways"," -log(p-value)","Ratio","Molecules"]
["Autoimmune Thyroid Disease Signaling","3.45E00","1.79E-01","HLA-A,HLA-C,HLA-B,HLA-DQA1,TSHR,HLA-DRB1,HLA-DQB1,HLA-DRB5,HLA-E,TG"]
["Antigen Presentation Pathway","3.23E00","2.14E-01","HLA-A,HLA-C,HLA-B,HLA-DQA1,HLA-DRB1,CD74,HLA-DQA2,HLA-DRB5,HLA-E"]
["Graft-versus-Host Disease Signaling","2.66E00","1.84E-01","KIR2DL1/KIR2DL3,HLA-A,HLA-C,HLA-B,HLA-DQA1,HLA-DRB1,HLA-DQB1,HLA-DRB5,HLA-E"]
["Allograft Rejection Signaling","2.39E00","1.48E-01","HLA-A,HLA-C,HLA-B,HLA-DQA1,HLA-DRB1,HLA-DQB1,HLA-DQA2,HLA-DRB5,HLA-E"]
["Axonal Guidance Signaling","2.37E00","9E-02","MMP21,ADAMTS7,ADAMTS8,PLXNA3,SLIT1,EPHB2,ADAM11,KRAS,PGF,MICAL1,NFAT5,EPHA8,MAP2K2,GLI3,SDC2,DCC,TUBA3C/TUBA3D,PLXNB1,MMP11,PSMD14,SHANK2,RASA1,PRKD3,SEMA3G,PAPPA,GNAS,SEMA5A,C9orf3,ARHGEF15,MMP2,HERC2,EPHA6,SRGAP3,SEMA4D,KIF7,RRAS2,TUBA1A,TUBB8,PLCG2,EPHA5,PRKCH,ADAM29,EPHA2"]
["Corticotropin Releasing Hormone Signaling","2.3E00","1.11E-01","NOS1,CRHR2,GNAS,ADCY6,ITPR1,EP300,BRAF,GLI3,MAP2K2,PLCG2,ITPR3,IVL,PRKCH,KRT1,PRKD3"]
["Cdc42 Signaling","2.26E00","1.1E-01","HLA-A,DIAPH3,HLA-B,HLA-DQA1,HLA-DRB1,HLA-DQB1,EXOC6,PARD6A,CLIP1,LLGL1,HLA-C,HLA-DQA2,PARD3,RASA1,HLA-DRB5,HLA-E,IQGAP3"]
["UVC-Induced MAPK Signaling","2.22E00","1.82E-01","BRAF,TP53,RRAS2,MAP2K2,KRAS,PRKCH,PRKD3,EGFR"]
["Crosstalk between Dendritic Cells and Natural Killer Cells","2.21E00","1.24E-01","KIR2DL1/KIR2DL3,TLR4,CSF2RB,TLN2,HLA-C,HLA-A,HLA-B,HLA-DRB1,TLN1,MICA,HLA-E,HLA-DRB5,IL2RB"]
["OX40 Signaling Pathway","2.04E00","1.38E-01","HLA-A,HLA-C,HLA-B,HLA-DQA1,HLA-DRB1,HLA-DQB1,HLA-DQA2,HLA-DRB5,HLA-E"]
["Methionine Salvage II (Mammalian)","1.89E00","2.22E-01","MTR,BHMT2"]
["Calcium-induced T Lymphocyte Apoptosis","1.84E00","1.34E-01","ITPR3,HLA-DQA1,HLA-DRB1,PRKCH,HLA-DQB1,ITPR1,PRKD3,HLA-DRB5,EP300"]
["Superpathway of Methionine Degradation","1.81E00","9.23E-02","CBS,MTR,EHMT1,BHMT2,GOT2,SUOX"]
["Thyroid Cancer Signaling","1.8E00","1.59E-01","BRAF,TP53,RRAS2,MAP2K2,KRAS,RET,CTNNB1"]
["Epithelial Adherens Junction Signaling","1.8E00","1.12E-01","MLLT4,KRAS,MYH7,CLIP1,MET,EPN2,NOTCH2,CTNNA2,TUBA1A,RRAS2,AGGF1,TUBB8,TUBA3C/TUBA3D,PARD3,CTNNB1,NOTCH1,EGFR"]
["Rac Signaling","1.7E00","1.02E-01","TIAM1,PTK2B,MAP3K1,PIKFYVE,KRAS,PARD6A,NOX1,ANK1,RRAS2,MAP2K2,PARD3,PI4KA,IQGAP3"]
["Prolactin Signaling","1.64E00","1.19E-01","STAT5A,RRAS2,SP1,MAP2K2,PLCG2,KRAS,NMI,PRKCH,PRKD3,EP300"]
["α-Adrenergic Signaling","1.59E00","1.04E-01","GNAS,RRAS2,MAP2K2,PLCG2,ITPR3,ADCY6,PYGB,KRAS,PRKCH,ITPR1,PRKD3"]
["Renin-Angiotensin Signaling","1.55E00","1.04E-01","RRAS2,GNAS,MAP2K2,PTK2B,PLCG2,ITPR3,MAP3K1,ADCY6,PRKCH,KRAS,ITPR1,PRKD3,NOX1"]
["UVA-Induced MAPK Signaling","1.52E00","1.17E-01","TP53,RRAS2,PARP10,TIPARP,PLCG2,RPS6KB2,RPS6KA3,PARP8,TNKS2,KRAS,EGFR"]
["Acute Myeloid Leukemia Signaling","1.49E00","1.19E-01","BRAF,CSF2RB,STAT5A,RRAS2,CCNA1,MAP2K2,RPS6KB2,KRAS,MAP2K3,PIM2"]
["Maturity Onset Diabetes of Young (MODY) Signaling","1.39E00","1.38E-01","NEUROD1,HNF1B,CACNA1S,CACNA1E"]
["GNRH Signaling","1.35E00","9.59E-02","GNAS,MAP3K1,ADCY6,KRAS,ITPR1,EP300,RRAS2,MAP2K2,ITPR3,PRKCH,MAP2K3,PRKD3,GNRHR,EGFR"]
["Gap Junction Signaling","1.34E00","9.09E-02","GNAS,ADCY6,KRAS,ITPR1,RRAS2,TUBA1A,SP1,MAP2K2,TUBB8,PLCG2,ITPR3,TUBA3C/TUBA3D,PRKCH,CTNNB1,PRKD3,EGFR"]
["Protein Kinase A Signaling","1.3E00","8.4E-02","PTK2B,PTPN13,LIPE,PTPRF,EP300,AKAP2,BRAF,TH,NFAT5,MAP2K2,GLI3,PTPRO,DCC,DUSP7,CTNNB1,PDE11A,PRKD3,PTPRT,APEX1,GNAS,PTPRD,RYR2,MAP3K1,ADCY6,PYGB,ITPR1,TTN,PLCG2,ITPR3,PTPRS,PRKCH,CDC27,DUSP16"]
["Germ Cell-Sertoli Cell Junction Signaling","1.28E00","9.58E-02","MAP3K1,MLLT4,LAMC3,KRAS,GSN,EPN2,CTNNA2,TUBA1A,AGGF1,RRAS2,MAP2K2,TUBB8,RHOT1,TUBA3C/TUBA3D,MAP2K3,CTNNB1"]
["Telomerase Signaling","1.25E00","1.09E-01","TP53,HDAC9,PPP2R1A,RRAS2,SP1,MAP2K2,HDAC10,KRAS,POT1,EGFR,IL2RB"]
["Purine Ribonucleosides Degradation to Ribose-1-phosphate","1.25E00","1.11E-01","ADAL,PGM2"]
["Pregnenolone Biosynthesis","1.25E00","1.54E-01","MICAL1,MICAL2"]
["Amyotrophic Lateral Sclerosis Signaling","1.23E00","8.94E-02","NOS1,TP53,GRIN3B,CACNA1S,CACNA1E,GRIN2C,NEFH,GRIK2,CASP7,PGF,GRIK1"]
["Dopamine-DARPP32 Feedback in cAMP Signaling","1.22E00","8.89E-02","NOS1,KCNJ12,PPP2R1A,CACNA1S,GRIN3B,CACNA1E,GNAS,GRIN2C,PLCG2,ITPR3,ADCY6,DRD5,PRKCH,ITPR1,PRKD3,EP300"]
["nNOS Signaling in Skeletal Muscle Cells","1.2E00","1.15E-01","NOS1,RYR2,DMD"]
["Circadian Rhythm Signaling","1.18E00","1.35E-01","PER3,GRIN3B,GRIN2C,PER2,EP300"]
["HER-2 Signaling in Breast Cancer","1.18E00","1.1E-01","TP53,RRAS2,KRAS,MMP2,PRKCH,PARD3,PRKD3,PARD6A,EGFR"]
["Glutamate Removal from Folates","1.17E00","3.33E-01","GGH"]
["Sorbitol Degradation I","1.17E00","2E-01","SORD"]
["Asparagine Biosynthesis I","1.17E00","1.25E-01","ASNS"]
["Sulfite Oxidation IV","1.17E00","2.5E-01","SUOX"]
["Ephrin Receptor Signaling","1.16E00","8.21E-02","GRIN3B,GNAS,EPHB2,PTPN13,ARHGEF15,KRAS,PGF,EP300,EPHA6,EPHA8,RRAS2,MAP2K2,SDC2,GRIN2C,EPHA5,EPHA2,RASA1"]
["HIF1α Signaling","1.15E00","1.01E-01","NOS1,TP53,RRAS2,SLC2A1,KRAS,MMP2,MMP11,APEX1,LDHA,PGF,EP300"]
["Thrombopoietin Signaling","1.14E00","1.09E-01","STAT5A,RRAS2,MAP2K2,PLCG2,KRAS,PRKCH,PRKD3"]
["Cholecystokinin/Gastrin-mediated Signaling","1.13E00","1.04E-01","RRAS2,MAP2K2,PTK2B,RHOT1,ITPR3,KRAS,MAP2K3,PRKCH,ITPR1,PRKD3,EGFR"]
["Inositol Pyrophosphates Biosynthesis","1.12E00","1.25E-01","IP6K3,IP6K2"]
["Phospholipase C Signaling","1.08E00","8.14E-02","HDAC9,GNAS,ARHGEF15,RPS6KA3,ADCY6,HDAC10,KRAS,ITPR1,EP300,RRAS2,NFAT5,AHNAK,MAP2K2,RHOT1,PLCG2,ITPR3,PRKCH,ARHGEF9,PRKD3,ARHGEF10,RALGDS"]
["GDNF Family Ligand-Receptor Interactions","1.08E00","1.05E-01","RRAS2,MAP2K2,PLCG2,ITPR3,KRAS,ITPR1,RET,RASA1"]
["Salvage Pathways of Pyrimidine Ribonucleotides","1.06E00","9.09E-02","BRAF,APOBEC1,MAP2K2,SGK1,APOBEC3H,PRPF4B,UPP1,GRK6,MAP2K3,PRKCH"]
["Ketolysis","1.02E00","1.18E-01","BDH1,ACAT2"]
["Type I Diabetes Mellitus Signaling","1.01E00","9.32E-02","HLA-A,HLA-C,HLA-B,HLA-DQA1,HLA-DRB1,MAP2K3,HLA-DQB1,HSPD1,HLA-DRB5,HLA-E,TNFRSF11B"]
["Nitric Oxide Signaling in the Cardiovascular System","9.89E-01","8.47E-02","CACNA1S,CACNA1E,MAP2K2,RYR2,ITPR3,PRKCH,ITPR1,PRKD3,ADRB3,PGF"]
["tRNA Charging","9.69E-01","6.17E-02","CARS,LARS2,AARS2,DARS2,SARS"]
["Inhibition of Matrix Metalloproteases","9.69E-01","1.28E-01","HSPG2,MMP21,SDC2,MMP2,MMP11"]
["Melanocyte Development and Pigmentation Signaling","9.66E-01","9.68E-02","GNAS,RRAS2,MAP2K2,PLCG2,RPS6KB2,ADCY6,RPS6KA3,KRAS,EP300"]
["IL-4 Signaling","9.44E-01","1.01E-01","NFAT5,RRAS2,HLA-DQA1,RPS6KB2,HLA-DRB1,KRAS,HLA-DQB1,HLA-DRB5"]
["B Cell Development","9.43E-01","1.25E-01","HLA-DQA1,HLA-DRB1,HLA-DQB1,HLA-DRB5"]
["Sertoli Cell-Sertoli Cell Junction Signaling","9.29E-01","8.25E-02","NOS1,MAP3K1,MLLT4,SPTA1,KRAS,EPN2,CTNNA2,TUBA1A,AGGF1,RRAS2,MAP2K2,TUBB8,TUBA3C/TUBA3D,MAP2K3,SPTAN1,CTNNB1"]
["Glycogen Degradation II","9.29E-01","1.33E-01","PYGB,PGM2"]
["Heme Biosynthesis II","9.29E-01","8.7E-02","ALAS2,CPOX"]
["Histidine Degradation VI","9.29E-01","1E-01","MICAL1,MICAL2"]
["Folate Transformations I","9.29E-01","6.25E-02","MTR,MTHFD1"]
["Neuregulin Signaling","9.19E-01","8.82E-02","STAT5A,RRAS2,MAP2K2,PLCG2,RPS6KB2,KRAS,PRKCH,PRKD3,EGFR"]
["Nur77 Signaling in T Lymphocytes","9.08E-01","1E-01","HDAC9,HLA-DQA1,HLA-DRB1,HLA-DQB1,HLA-DRB5,EP300"]
["Neuroprotective Role of THOP1 in Alzheimer's Disease","8.98E-01","9.09E-02","HLA-A,HLA-C,MAPT,HLA-B,HLA-E"]
["ERK5 Signaling","8.97E-01","1.04E-01","RRAS2,SGK1,RPS6KB2,RPS6KA3,KRAS,EGFR,EP300"]
["Pyridoxal 5'-phosphate Salvage Pathway","8.97E-01","9.59E-02","BRAF,MAP2K2,SGK1,PRPF4B,GRK6,MAP2K3,PRKCH"]
["CDK5 Signaling","8.96E-01","9.38E-02","LAMC1,PPP2R1A,GNAS,RRAS2,MAP2K2,MAPT,ADCY6,DRD5,KRAS"]
["Hereditary Breast Cancer Signaling","8.89E-01","8.53E-02","TP53,HDAC9,RRAS2,XPC,HDAC10,SLC19A1,KRAS,RFC1,BRCA1,SMARCA4,EP300"]
["Alanine Degradation III","8.88E-01","1.67E-01","GPT2"]
["Alanine Biosynthesis II","8.88E-01","1.67E-01","GPT2"]
["Uridine-5'-phosphate Biosynthesis","8.88E-01","5E-02","CAD"]
["Cysteine Biosynthesis/Homocysteine Degradation","8.88E-01","1.25E-01","CBS"]
["Putrescine Biosynthesis III","8.88E-01","2.5E-01","ADC"]
["Endometrial Cancer Signaling","8.78E-01","1E-01","TP53,CTNNA2,RRAS2,MAP2K2,KRAS,CTNNB1"]
["Aldosterone Signaling in Epithelial Cells","8.71E-01","8.38E-02","SCNN1A,SCNN1G,MAP2K2,SGK1,PLCG2,ITPR3,HSPA13,PIKFYVE,PRKCH,KRAS,HSPD1,ITPR1,PRKD3,PI4KA"]
["Breast Cancer Regulation by Stathmin1","8.67E-01","8.06E-02","TP53,GNAS,ARHGEF15,ADCY6,KRAS,ITPR1,PPP2R1A,TUBA1A,RRAS2,MAP2K2,TUBB8,ITPR3,TUBA3C/TUBA3D,PRKCH,ARHGEF10,ARHGEF9,PRKD3"]
["Estrogen Receptor Signaling","8.63E-01","8.89E-02","CCNH,RRAS2,MAP2K2,GTF2E1,NR0B1,MED16,KRAS,GTF2F1,MED13L,MED12,SMARCA4,EP300"]
["Virus Entry via Endocytic Pathways","8.53E-01","8.91E-02","RRAS2,HLA-A,HLA-C,PLCG2,HLA-B,KRAS,PRKCH,AP1B1,PRKD3"]
["Ketogenesis","8.51E-01","1E-01","BDH1,ACAT2"]
["Oleate Biosynthesis II (Animals)","8.51E-01","1.25E-01","UFSP1,PTPRT"]
["NAD Phosphorylation and Dephosphorylation","8.51E-01","1.18E-01","NADK,ACPP"]
["Methylglyoxal Degradation III","8.51E-01","1.18E-01","AKR7A2,AKR1A1"]
["Glycine Betaine Degradation","8.51E-01","8.7E-02","DMGDH,BHMT2"]
["IL-2 Signaling","8.5E-01","9.84E-02","STAT5A,RRAS2,MAP2K2,PTK2B,KRAS,IL2RB"]
["Non-Small Cell Lung Cancer Signaling","8.46E-01","8.43E-02","TP53,RRAS2,MAP2K2,ITPR3,KRAS,ITPR1,EGFR"]
["DNA Methylation and Transcriptional Repression Signaling","8.35E-01","1.3E-01","CHD3,CHD4,ARID4B"]
["Melanoma Signaling","8.32E-01","1E-01","BRAF,TP53,RRAS2,MAP2K2,KRAS"]
["Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells","8.23E-01","1.08E-01","HLA-A,HLA-C,HLA-B,CASP7"]
["Remodeling of Epithelial Adherens Junctions","8.21E-01","1.03E-01","MET,CTNNA2,TUBA1A,TUBB8,TUBA3C/TUBA3D,CTNNB1,CLIP1"]
["Synaptic Long Term Potentiation","8.15E-01","8.73E-02","GRIN3B,RRAS2,MAP2K2,GRIN2C,PLCG2,ITPR3,KRAS,PRKCH,ITPR1,PRKD3,EP300"]
["Erythropoietin Signaling","7.97E-01","8.86E-02","STAT5A,RRAS2,MAP2K2,PLCG2,KRAS,PRKCH,PRKD3"]
["Role of CHK Proteins in Cell Cycle Checkpoint Control","7.95E-01","1.02E-01","TP53,PPP2R1A,SLC19A1,RFC1,TLK2,BRCA1"]
["Regulation of Cellular Mechanics by Calpain Protease","7.95E-01","8.45E-02","TLN2,RRAS2,CCNA1,TLN1,KRAS,EGFR"]
["Acyl-CoA Hydrolysis","7.83E-01","1.43E-01","GNPAT,ACOT4"]
["Glycogen Degradation III","7.83E-01","1.18E-01","PYGB,PGM2"]
["Chemokine Signaling","7.74E-01","9.46E-02","CCR5,RRAS2,MAP2K2,PTK2B,PLCG2,KRAS,NOX1"]
["NGF Signaling","7.66E-01","8.26E-02","TP53,RRAS2,MAP2K2,PLCG2,MAP3K1,RPS6KB2,RPS6KA3,TRIO,KRAS,EP300"]
["fMLP Signaling in Neutrophils","7.48E-01","7.69E-02","NFAT5,GNAS,RRAS2,MAP2K2,ITPR3,KRAS,PRKCH,ITPR1,PRKD3,NOX1"]
["Glioma Invasiveness Signaling","7.45E-01","9.23E-02","RRAS2,RHOT1,VTN,ITGAV,KRAS,MMP2"]
["Communication between Innate and Adaptive Immune Cells","7.4E-01","7.84E-02","TLR4,TLR10,HLA-A,HLA-C,HLA-B,HLA-DRB1,HLA-DRB5,HLA-E"]
["Gαs Signaling","7.31E-01","8.26E-02","BRAF,GNAS,MAP2K2,RYR2,ADCY6,DRD5,CHRM3,ADORA2A,ADRB3,EP300"]
["Coenzyme A Biosynthesis","7.27E-01","7.14E-02","PPCDC"]
["D-glucuronate Degradation I","7.27E-01","7.69E-02","AKR1A1"]
["Glutamate Degradation II","7.27E-01","1E-01","GOT2"]
["Aspartate Biosynthesis","7.27E-01","1.43E-01","GOT2"]
["Ubiquinol-10 Biosynthesis (Eukaryotic)","7.22E-01","6.9E-02","MICAL1,MICAL2"]
["Oncostatin M Signaling","7.21E-01","1.14E-01","STAT5A,RRAS2,MAP2K2,KRAS"]
["ErbB4 Signaling","7.21E-01","8.96E-02","RRAS2,MAP2K2,PLCG2,KRAS,PRKCH,PRKD3"]
["nNOS Signaling in Neurons","7.16E-01","9.8E-02","NOS1,GRIN3B,GRIN2C,PRKCH,PRKD3"]
["GABA Receptor Signaling","7.16E-01","9.09E-02","GABRG3,GABARAP,AP1B1,SLC6A13,GABRE"]
["Synaptic Long Term Depression","7.15E-01","7.89E-02","NOS1,PPP2R1A,GNAS,RRAS2,MAP2K2,PLCG2,RYR2,ITPR3,KRAS,PRKCH,ITPR1,PRKD3"]
["IL-3 Signaling","7.08E-01","9.33E-02","CSF2RB,STAT5A,RRAS2,MAP2K2,KRAS,PRKCH,PRKD3"]
["PEDF Signaling","7.08E-01","8.86E-02","TP53,HNF1B,RRAS2,KRAS,DOCK3,WASF2,CASP7"]
["Role of NFAT in Cardiac Hypertrophy","6.98E-01","7.54E-02","HDAC9,GNAS,MAP3K1,ADCY6,HDAC10,KRAS,ITPR1,EP300,RRAS2,MAP2K2,PLCG2,ITPR3,MAP2K3,PRKCH,PRKD3"]
["Cellular Effects of Sildenafil (Viagra)","6.83E-01","7.38E-02","KCNN3,CACNA1S,CACNA1E,GNAS,PLCG2,ITPR3,ADCY6,CACNG7,MYH7,ITPR1,CACNG8"]
["ErbB Signaling","6.82E-01","8.89E-02","RRAS2,MAP2K2,PLCG2,KRAS,MAP2K3,PRKCH,PRKD3,EGFR"]
["Role of BRCA1 in DNA Damage Response","6.75E-01","8.45E-02","TP53,ATRIP,SLC19A1,RFC1,BRCA1,SMARCA4"]
["Role of JAK1 and JAK3 in γc Cytokine Signaling","6.75E-01","9.09E-02","STAT5A,RRAS2,PTK2B,KRAS,CRLF2,IL2RB"]
["Assembly of RNA Polymerase III Complex","6.68E-01","1.25E-01","BDP1,BRF1"]
["Dermatan Sulfate Degradation (Metazoa)","6.68E-01","9.52E-02","IDS,FGFRL1"]
["LPS-stimulated MAPK Signaling","6.67E-01","8.54E-02","TLR4,RRAS2,MAP2K2,KRAS,MAP2K3,PRKCH,PRKD3"]
["NF-κB Activation by Viruses","6.67E-01","8.54E-02","CCR5,RRAS2,MAP3K1,ITGAV,KRAS,PRKCH,PRKD3"]
["Bladder Cancer Signaling","6.64E-01","8.51E-02","TP53,RRAS2,MAP2K2,KRAS,MMP2,MMP11,PGF,EGFR"]
["FAK Signaling","6.64E-01","7.62E-02","TLN2,RRAS2,MAP2K2,PLCG2,TLN1,KRAS,TNS1,EGFR"]
["CNTF Signaling","6.41E-01","9.26E-02","RRAS2,MAP2K2,RPS6KB2,RPS6KA3,KRAS"]
["Bupropion Degradation","6.34E-01","9.38E-02","CYP2D6,CYP3A5,CYP3A7"]
["Notch Signaling","6.32E-01","9.52E-02","NOTCH2,MAML3,JAG1,NOTCH1"]
["Estrogen-Dependent Breast Cancer Signaling","6.32E-01","8.33E-02","STAT5A,RRAS2,SP1,KRAS,EGFR,EP300"]
["Phenylalanine Degradation IV (Mammalian, via Side Chain)","6.2E-01","5.13E-02","GOT2,MAOA"]
["Vitamin-C Transport","6.2E-01","9.09E-02","TXNDC2,SLC2A1"]
["CREB Signaling in Neurons","6.17E-01","7.11E-02","GNAS,ADCY6,KRAS,ITPR1,EP300,RRAS2,MAP2K2,GRIN2C,PLCG2,ITPR3,PRKCH,GRIK2,PRKD3,GRIK1"]
["Heme Biosynthesis from Uroporphyrinogen-III I","6.16E-01","9.09E-02","CPOX"]
["Catecholamine Biosynthesis","6.16E-01","6.67E-02","TH"]
["Myo-inositol Biosynthesis","6.16E-01","1.25E-01","IMPA2"]
["Geranylgeranyldiphosphate Biosynthesis","6.16E-01","1.25E-01","FDPS"]
["Melatonin Degradation II","6.16E-01","8.33E-02","MAOA"]
["Trans, trans-farnesyl Diphosphate Biosynthesis","6.16E-01","1.11E-01","FDPS"]
["Rapoport-Luebering Glycolytic Shunt","6.16E-01","1.11E-01","PGAM2"]
["L-cysteine Degradation I","6.16E-01","9.09E-02","GOT2"]
["Molecular Mechanisms of Cancer","6.15E-01","6.84E-02","KRAS,EP300,BRAF,SYNGAP1,CTNNA2,MAP2K2,RHOT1,CTNNB1,BRCA1,RASA1,PRKD3,RALGDS,TP53,GNAS,ARHGEF15,ADCY6,AURKA,DAXX,RRAS2,NF1,PRKCH,MAP2K3,ARHGEF10,ARHGEF9,NOTCH1,CASP7"]
["VEGF Family Ligand-Receptor Interactions","6.1E-01","7.95E-02","RRAS2,MAP2K2,PLCG2,KRAS,PRKCH,PRKD3,PGF"]
["14-3-3-mediated Signaling","6.05E-01","8.33E-02","RRAS2,TUBA1A,MAP2K2,TUBB8,PLCG2,MAPT,TUBA3C/TUBA3D,KRAS,PRKCH,PRKD3"]
["Antiproliferative Role of TOB in T Cell Signaling","6.01E-01","1.15E-01","PABPC1,CCNA1,CUL1"]
["Acetone Degradation I (to Methylglyoxal)","6.01E-01","8.57E-02","CYP2D6,CYP3A5,CYP3A7"]
["Cyclins and Cell Cycle Regulation","5.93E-01","7.53E-02","TP53,HDAC9,CCNH,PPP2R1A,CCNA1,CUL1,HDAC10"]
["PDGF Signaling","5.93E-01","8.14E-02","RRAS2,SPHK2,MAP2K2,PLCG2,MAP3K1,KRAS,RASA1"]
["Ovarian Cancer Signaling","5.83E-01","7.33E-02","BRAF,TP53,RRAS2,MAP2K2,RPS6KB2,KRAS,MMP2,BRCA1,CTNNB1,PGF,EGFR"]
["Gαq Signaling","5.78E-01","7.14E-02","GNAS,MAP2K2,PTK2B,RHOT1,PLCG2,ITPR3,CALCR,PRKCH,ARHGEF25,ITPR1,PRKD3,CHRM3"]
["Telomere Extension by Telomerase","5.76E-01","1.11E-01","TNKS2,POT1"]
["UVB-Induced MAPK Signaling","5.74E-01","8.77E-02","TP53,RPS6KA3,PRKCH,PRKD3,EGFR"]
["D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis","5.7E-01","7.89E-02","PLCG2,PIKFYVE,PI4KA"]
["Thrombin Signaling","5.68E-01","7.25E-02","GNAS,ARHGEF15,ADCY6,KRAS,ITPR1,RRAS2,MAP2K2,RHOT1,PLCG2,ITPR3,PRKCH,ARHGEF10,ARHGEF9,PRKD3,EGFR"]
["Chronic Myeloid Leukemia Signaling","5.64E-01","7.69E-02","TP53,HDAC9,STAT5A,RRAS2,MAP2K2,HDAC10,KRAS,CBLC"]
["Superpathway of Melatonin Degradation","5.53E-01","6.76E-02","CYP2D6,CYP3A5,CYP3A7,SULT1A2,MAOA"]
["HMGB1 Signaling","5.48E-01","7.34E-02","TLR4,RRAS2,SP1,MAP2K2,RHOT1,KRAS,MAP2K3,TNFRSF11B"]
["Ceramide Signaling","5.42E-01","7.69E-02","PPP2R1A,RRAS2,SPHK2,MAP3K1,KRAS,KSR1,TNFRSF11B"]
["Prostate Cancer Signaling","5.42E-01","7E-02","TP53,RRAS2,AR,MAP2K2,KRAS,CTNNB1,EP300"]
["CCR5 Signaling in Macrophages","5.36E-01","6.67E-02","CCR5,GNAS,PTK2B,PLCG2,PRKCH,PRKD3"]
["T Helper Cell Differentiation","5.36E-01","8.57E-02","HLA-DQA1,HLA-DRB1,HLA-DQB1,BCL6,HLA-DRB5,TNFRSF11B"]
["Melatonin Signaling","5.36E-01","7.69E-02","BRAF,MAP2K2,PLCG2,MAP2K3,PRKCH,PRKD3"]
["Mismatch Repair in Eukaryotes","5.36E-01","8.33E-02","SLC19A1,RFC1"]
["Tryptophan Degradation X (Mammalian, via Tryptamine)","5.36E-01","7.41E-02","AKR1A1,MAOA"]
["Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)","5.36E-01","5.88E-02","FDPS,ACAT2"]
["Pyruvate Fermentation to Lactate","5.34E-01","1.11E-01","LDHA"]
["Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate","5.34E-01","1E-01","MTHFD1"]
["Tetrapyrrole Biosynthesis II","5.34E-01","7.69E-02","ALAS2"]
["Citrulline-Nitric Oxide Cycle","5.34E-01","6.25E-02","NOS1"]
["GDP-glucose Biosynthesis","5.34E-01","6.25E-02","PGM2"]
["Folate Polyglutamylation","5.34E-01","5.56E-02","MTHFD1"]
["Glioma Signaling","5.33E-01","7.14E-02","TP53,RRAS2,MAP2K2,PLCG2,KRAS,PRKCH,PRKD3,EGFR"]
["Signaling by Rho Family GTPases","5.26E-01","6.79E-02","GNAS,PTK2B,ARHGEF15,DIAPH3,PIKFYVE,CDC42EP3,SEPT11,CDH15,PARD6A,CLIP1,NOX1,MAP2K2,RHOT1,CDH10,PARD3,ARHGEF10,ARHGEF9,PI4KA"]
["Growth Hormone Signaling","5.19E-01","7.79E-02","STAT5A,PLCG2,RPS6KB2,RPS6KA3,PRKCH,PRKD3"]
["Macropinocytosis Signaling","5.19E-01","7.79E-02","MET,RRAS2,PLCG2,KRAS,PRKCH,PRKD3"]
["Renal Cell Carcinoma Signaling","5.02E-01","7.69E-02","MET,RRAS2,MAP2K2,SLC2A1,KRAS,EP300"]
["Granzyme A Signaling","5E-01","1.11E-01","APEX1,EP300"]
["eNOS Signaling","4.99E-01","6.76E-02","AQP7,GNAS,CCNA1,PLCG2,ITPR3,ADCY6,ITPR1,AQP6,AQP2,PGF"]
["ErbB2-ErbB3 Signaling","4.95E-01","8.06E-02","STAT5A,RRAS2,SP1,MAP2K2,KRAS"]
["EGF Signaling","4.95E-01","7.81E-02","MAP3K1,ITPR3,ITPR1,RASA1,EGFR"]
["Cell Cycle: G2/M DNA Damage Checkpoint Regulation","4.89E-01","8.33E-02","TP53,CUL1,BRCA1,EP300"]
["FLT3 Signaling in Hematopoietic Progenitor Cells","4.7E-01","8E-02","STAT5A,RRAS2,MAP2K2,RPS6KA3,KRAS,EP300"]
["Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency","4.69E-01","7.84E-02","TP53,NR5A2,BRCA1,SALL4"]
["Glucose and Glucose-1-phosphate Degradation","4.68E-01","4.76E-02","PGM2"]
["Ceramide Biosynthesis","4.68E-01","6.25E-02","SPTLC2"]
["Thioredoxin Pathway","4.68E-01","1.25E-01","TXNDC2"]
["Selenocysteine Biosynthesis II (Archaea and Eukaryotes)","4.68E-01","5.88E-02","SARS"]
["Adenine and Adenosine Salvage III","4.68E-01","6.25E-02","ADAL"]
["Aspartate Degradation II","4.68E-01","7.69E-02","GOT2"]
["IL-8 Signaling","4.67E-01","6.33E-02","GNAS,PTK2B,KRAS,MMP2,NOX1,PGF,BRAF,RRAS2,MAP2K2,RHOT1,ITGAV,PRKCH,PRKD3,EGFR"]
["Cysteine Biosynthesis III (mammalia)","4.67E-01","6.45E-02","CBS,EHMT1"]
["Endoplasmic Reticulum Stress Pathway","4.67E-01","1.05E-01","ERN1,CASP7"]
["Neuropathic Pain Signaling In Dorsal Horn Neurons","4.64E-01","7.41E-02","KCNN3,GRIN3B,GRIN2C,PLCG2,ITPR3,PRKCH,ITPR1,PRKD3"]
["HGF Signaling","4.64E-01","7.27E-02","MET,RRAS2,MAP2K2,PLCG2,MAP3K1,KRAS,PRKCH,PRKD3"]
["CD28 Signaling in T Helper Cells","4.63E-01","6.77E-02","NFAT5,MAP2K2,MAP3K1,ITPR3,HLA-DQA1,HLA-DRB1,HLA-DQB1,ITPR1,HLA-DRB5"]
["PKCθ Signaling in T Lymphocytes","4.63E-01","6.57E-02","NFAT5,RRAS2,PLCG2,MAP3K1,HLA-DQA1,HLA-DRB1,KRAS,HLA-DQB1,HLA-DRB5"]
["Sperm Motility","4.63E-01","6.52E-02","CACNA1G,GNAS,PTK2B,ZAN,PLCG2,ITPR3,PRKCH,ITPR1,PRKD3"]
["Caveolar-mediated Endocytosis Signaling","4.55E-01","7.23E-02","HLA-A,HLA-C,HLA-B,ITGAV,COPB2,EGFR"]
["TREM1 Signaling","4.55E-01","6.9E-02","TLR4,STAT5A,TLR10,NLRP1,PLCG2,NLRC3"]
["Insulin Receptor Signaling","4.52E-01","6.9E-02","SCNN1A,SCNN1G,RRAS2,MAP2K2,SGK1,RPS6KB2,LIPE,KRAS,STXBP4,PTPRF"]
["ATM Signaling","4.43E-01","7.69E-02","TP53,TLK2,BRCA1,EP300,SMC1A"]
["Inhibition of Angiogenesis by TSP1","4.4E-01","7.5E-02","HSPG2,TP53,SDC2"]
["RhoGDI Signaling","4.37E-01","6.5E-02","GNAS,RHOT1,ARHGEF15,CDH10,PIKFYVE,ARHGAP4,ARHGDIA,WASF2,CDH15,ARHGEF10,ARHGEF9,PI4KA,EP300"]
["GADD45 Signaling","4.36E-01","9.09E-02","TP53,BRCA1"]
["Tryptophan Degradation III (Eukaryotic)","4.36E-01","4.35E-02","ACAT2,KYNU"]
["DNA damage-induced 14-3-3σ Signaling","4.36E-01","9.09E-02","TP53,BRCA1"]
["Huntington's Disease Signaling","4.36E-01","6.56E-02","TP53,NEUROD1,SDHA,HDAC9,SGK1,SH3GL3,HDAC10,ITPR1,EP300,SP1,TCERG1,PRKCH,PRKD3,RASA1,CASP7,EGFR"]
["Antiproliferative Role of Somatostatin Receptor 2","4.27E-01","7.35E-02","NOS1,BRAF,RRAS2,MAP2K2,KRAS"]
["G Beta Gamma Signaling","4.26E-01","6.03E-02","GNAS,RRAS2,PLCG2,KRAS,PRKCH,PRKD3,EGFR"]
["Apoptosis Signaling","4.26E-01","7.07E-02","TP53,RRAS2,MAP2K2,PLCG2,KRAS,SPTAN1,CASP7"]
["Glioblastoma Multiforme Signaling","4.22E-01","6.63E-02","TP53,RRAS2,MAP2K2,NF1,RHOT1,PLCG2,ITPR3,KRAS,ITPR1,CTNNB1,EGFR"]
["Gα12/13 Signaling","4.17E-01","7.14E-02","RRAS2,MAP2K2,PTK2B,CDH10,MAP3K1,KRAS,CDH15,CTNNB1,RASA1"]
["Tryptophan Degradation to 2-amino-3-carboxymuconate Semialdehyde","4.15E-01","5.88E-02","KYNU"]
["Mineralocorticoid Biosynthesis","4.15E-01","5.56E-02","CYP11B1"]
["iCOS-iCOSL Signaling in T Helper Cells","4.15E-01","6.56E-02","NFAT5,ITPR3,HLA-DQA1,HLA-DRB1,HLA-DQB1,ITPR1,HLA-DRB5,IL2RB"]
["Colorectal Cancer Metastasis Signaling","4.15E-01","6.59E-02","TP53,GNAS,ADCY6,KRAS,MMP2,PGF,BRAF,TLR4,TLR10,RRAS2,MAP2K2,RHOT1,DCC,MMP11,CTNNB1,RALGDS,EGFR"]
["Dopamine Receptor Signaling","4.12E-01","6.32E-02","TH,PPP2R1A,GNAS,ADCY6,DRD5,MAOA"]
["IL-15 Signaling","4.12E-01","6.94E-02","STAT5A,RRAS2,MAP2K2,KRAS,IL2RB"]
["p70S6K Signaling","4.06E-01","6.92E-02","PPP2R1A,RRAS2,MAP2K2,PLCG2,MAPT,KRAS,PRKCH,PRKD3,EGFR"]
["P2Y Purigenic Receptor Signaling Pathway","4.06E-01","6.43E-02","GNAS,RRAS2,MAP2K2,PLCG2,ADCY6,KRAS,PRKCH,PRKD3,EP300"]
["Ephrin A Signaling","3.96E-01","7.41E-02","EPHA6,EPHA8,EPHA5,EPHA2"]
["Melatonin Degradation I","3.96E-01","6.78E-02","CYP2D6,CYP3A5,CYP3A7,SULT1A2"]
["NRF2-mediated Oxidative Stress Response","3.92E-01","6.77E-02","AKR7A2,AKR1A1,RRAS2,MAP2K2,STIP1,ABCC1,MAP3K1,PRKCH,MAP2K3,KRAS,PRKD3,BACH1,EP300"]
["Dopamine Degradation","3.82E-01","5.71E-02","SULT1A2,MAOA"]
["Hepatic Cholestasis","3.8E-01","5.59E-02","ABCG8,TLR4,GNAS,ABCC1,PPRC1,ADCY6,NR5A2,PRKCH,PRKD3,TNFRSF11B"]
["Regulation of the Epithelial-Mesenchymal Transition Pathway","3.75E-01","6.7E-02","BRAF,MET,PYGO1,RRAS2,MAP2K2,MAP2K3,MMP2,KRAS,FGFRL1,JAG1,NOTCH1,PARD6A,EGFR"]
["Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes","3.73E-01","6.82E-02","NFAT5,RRAS2,MAP2K2,PLCG2,MAP3K1,KRAS"]
["Airway Pathology in Chronic Obstructive Pulmonary Disease","3.71E-01","9.09E-02","MMP2"]
["Histidine Degradation III","3.71E-01","5.56E-02","MTHFD1"]
["Glucocorticoid Biosynthesis","3.71E-01","5.56E-02","CYP11B1"]
["Role of Tissue Factor in Cancer","3.71E-01","6.35E-02","TP53,STAT5A,RRAS2,PTK2B,ITGAV,RPS6KA3,KRAS,EGFR"]
["CXCR4 Signaling","3.66E-01","6.4E-02","GNAS,RRAS2,MAP2K2,RHOT1,ITPR3,ADCY6,KRAS,PRKCH,ITPR1,PRKD3,ELMO1"]
["Actin Cytoskeleton Signaling","3.61E-01","6.3E-02","TIAM1,DIAPH3,PIKFYVE,TRIO,TLN1,KRAS,MYH7,GSN,TTN,RRAS2,TLN2,MAP2K2,WASF2,SSH2,IQGAP3"]
["G-Protein Coupled Receptor Signaling","3.61E-01","6.62E-02","GPR17,GNAS,PTK2B,ADCY6,DRD5,KRAS,CHRM3,ADRB3,EP300,BRAF,SYNGAP1,RRAS2,MAP2K2,CALCR,PDE11A,ADORA2A,APEX1,RASA1"]
["Polyamine Regulation in Colon Cancer","3.58E-01","6.67E-02","KRAS,CTNNB1"]
["Gluconeogenesis I","3.58E-01","4.35E-02","PGAM2,ME1"]
["Role of NFAT in Regulation of the Immune Response","3.54E-01","6.12E-02","NFAT5,GNAS,RRAS2,MAP2K2,PLCG2,ITPR3,HLA-DQA1,HLA-DRB1,KRAS,HLA-DQB1,ITPR1,HLA-DRB5"]
["Endothelin-1 Signaling","3.54E-01","6.42E-02","NOS1,BRAF,GNAS,RRAS2,PLCG2,ITPR3,ADCY6,KRAS,PRKCH,ITPR1,PRKD3,CASP7"]
["Natural Killer Cell Signaling","3.5E-01","6.84E-02","KIR2DL1/KIR2DL3,RRAS2,MAP2K2,PLCG2,KRAS,PRKCH,PRKD3,LILRB1"]
["Estrogen Biosynthesis","3.43E-01","6.25E-02","CYP2D6,CYP3A5,CYP3A7"]
["Androgen Signaling","3.4E-01","5.76E-02","CCNH,GNAS,AR,GTF2E1,GTF2F1,PRKCH,PRKD3,EP300"]
["Altered T Cell and B Cell Signaling in Rheumatoid Arthritis","3.37E-01","6.32E-02","TLR4,TLR10,HLA-DQA1,HLA-DRB1,HLA-DQB1,HLA-DRB5"]
["Glutathione-mediated Detoxification","3.36E-01","5.13E-02","GGH,ANPEP"]
["Semaphorin Signaling in Neurons","3.35E-01","7.41E-02","MET,SEMA4D,RHOT1,PLXNB1"]
["Pathogenesis of Multiple Sclerosis","3.34E-01","1E-01","CCR5"]
["Assembly of RNA Polymerase I Complex","3.34E-01","7.69E-02","POLR1D"]
["Calcium Transport I","3.34E-01","7.69E-02","ATP2B3"]
["Calcium Signaling","3.31E-01","5.91E-02","HDAC9,GRIN3B,NFAT5,ATP2B3,GRIN2C,RYR2,ITPR3,HDAC10,MYH7,ITPR1,EP300,GRIK1"]
["Neurotrophin/TRK Signaling","3.3E-01","6.67E-02","RRAS2,MAP2K2,KRAS,MAP2K3,EP300"]
["B Cell Receptor Signaling","3.24E-01","6.4E-02","NFAT5,RRAS2,MAP2K2,POU2F2,PLCG2,MAP3K1,RPS6KB2,KRAS,MAP2K3,BCL6,EP300"]
["Triacylglycerol Degradation","3.15E-01","6.45E-02","ABHD6,LIPE"]
["p53 Signaling","3.14E-01","6.19E-02","TP53,HDAC9,JMY,TOPBP1,BRCA1,CTNNB1,EP300"]
["CCR3 Signaling in Eosinophils","3.12E-01","6.06E-02","GNAS,RRAS2,MAP2K2,ITPR3,KRAS,PRKCH,ITPR1,PRKD3"]
["Netrin Signaling","3.1E-01","5.56E-02","NFAT5,RYR2,DCC"]
["Mechanisms of Viral Exit from Host Cells","2.95E-01","6.67E-02","SH3GL3,PRKCH,PRKD3"]
["FGF Signaling","2.95E-01","6.45E-02","MET,MAP3K1,MAP2K3,FGFRL1,ITPR1,EP300"]
["Toll-like Receptor Signaling","2.83E-01","6.25E-02","TLR4,TLR10,MAP3K1,MAP2K3"]
["Glutamate Receptor Signaling","2.83E-01","5.8E-02","GRIN3B,GRIN2C,GRIK2,GRIK1"]
["MIF Regulation of Innate Immunity","2.81E-01","5.77E-02","TP53,TLR4,CD74"]
["FcγRIIB Signaling in B Lymphocytes","2.81E-01","5E-02","RRAS2,PLCG2,KRAS"]
["Role of IL-17F in Allergic Inflammatory Airway Diseases","2.81E-01","6.82E-02","MAP2K2,RPS6KA3,EP300"]
["Cardiac β-adrenergic Signaling","2.79E-01","5.84E-02","AKAP2,CACNA1S,PPP2R1A,CACNA1E,GNAS,RYR2,ADCY6,PDE11A,APEX1"]
["IL-17 Signaling","2.74E-01","6.67E-02","MUC5B,RRAS2,MAP2K2,KRAS,MAP2K3"]
["Glutaryl-CoA Degradation","2.73E-01","4.35E-02","ACAT2"]
["PTEN Signaling","2.7E-01","5.76E-02","RRAS2,MAP2K2,RPS6KB2,PREX2,KRAS,FGFRL1,FOXG1,EGFR"]
["Ephrin B Signaling","2.64E-01","6.17E-02","GNAS,EPHB2,CAP1,ITSN2,CTNNB1"]
["STAT3 Pathway","2.64E-01","6.25E-02","RRAS2,MAP2K2,KRAS,FGFRL1,EGFR"]
["Pyrimidine Ribonucleotides De Novo Biosynthesis","2.62E-01","3.92E-02","ENTPD2,CAD"]
["Superpathway of Cholesterol Biosynthesis","2.62E-01","2.38E-02","FDPS,ACAT2"]
["VEGF Signaling","2.57E-01","5.66E-02","RRAS2,MAP2K2,PTK2B,PLCG2,KRAS,PGF"]
["Retinoic acid Mediated Apoptosis Signaling","2.49E-01","6.15E-02","PARP10,TIPARP,PARP8,TNKS2"]
["Mevalonate Pathway I","2.48E-01","3.85E-02","ACAT2"]
["Intrinsic Prothrombin Activation Pathway","2.46E-01","5.56E-02","F9,F5"]
["NAD biosynthesis II (from tryptophan)","2.26E-01","3.03E-02","KYNU"]
["Bile Acid Biosynthesis, Neutral Pathway","2.26E-01","1.72E-02","BAAT"]
["DNA Double-Strand Break Repair by Homologous Recombination","2.07E-01","5.56E-02","BRCA1"]
["Isoleucine Degradation I","2.07E-01","3.45E-02","ACAT2"]
["Superpathway of Citrulline Metabolism","2.07E-01","2.63E-02","NOS1"]
["Leukotriene Biosynthesis","2.07E-01","4E-02","ALOX5"]
["γ-glutamyl Cycle","2.07E-01","3.7E-02","ANPEP"]