{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Legend","Sheet2","Sheet3"],"not_rendered":{"images":1,"external_links":1},"read":"whole","date_system":"1904","formulas":"cached_only"}

{"sheet":"Legend","index":0,"n_rows":1,"n_cols":1,"rows_kept":1,"merged":[[0,0,0,10]],"flags":["formulas_cached_only"]}
["The Venn diagram from Figure 5a is reproduced in Sheet 2 indicating the pools analyzed in columns B-H. Rows 3–13 show the CT values for both endogenous reference standards (GAPDH and ACTB) performed in quadruplicate on the seven pools. The average CT for GAPDH and ACTB for each pool and their standard deviations are shown in bold.  Below that, the numbers for each gene are shown in its own 20-row box, with the gene name shown in column A. The duplicate CT values for that gene in each pool are shown along with the average CT values written in bold type with the associated standard deviation. One row below that is the calculated average DCT for that gene against GAPDH as the endogenous reference. In the blue box, each pool-by-pool comparison using GAPDH as the reference is shown along with the calculated –DDCT in column B, the relative quantitation calculated using the formula RQ = 2–DDCT in column C and the fold-change value, up or down, in column D. If the gene is upregulated, RQ is used directly but if the gene is downregulated the fold-change value is calculated as 1/RQ.  The format of the rows and columns is the same in the orange box using ACTB as the endogenous reference standard. Two different endogenous controls were employed to reduce variability that might exist between normal, hyperplastic and tumor-containing mammary tissues.  For ease of comparison, the raw numbers that generated the heat map shown in Figure 5b were extracted from the microarray data and reproduced in the yellow box. The relative quantitation (RQ), fold-change value, range and t-test p-value are shown in columns E-H, respectively. Note that the Pool no. 6 vs Pool no. 7 qRT-PCR results (last row in the blue and orange boxes) are reported here but were not shown as microarray data in Figure 5. This is because, although the trends in direction of regulation were consistent for most of the genes analyzed, the fold-change value for about 50% of the genes did not meet the twofold threshold cut off used to generate the heat map (denoted by asterisks in the yellow box)."]

{"sheet":"Sheet2","index":1,"n_rows":394,"n_cols":8,"rows_kept":394,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
["The Venn diagram from Figure 5a is reproduced here indicating the pools analyzed in columns B-H. Rows 3–13 show the CT values for both endogenous reference standards (GAPDH and ACTB) performed in quadruplicate on the seven pools. The average CT for GAPDH and ACTB for each pool and their standard deviations are shown in bold.  Below that, the numbers for each gene are shown in its own 20-row box, with the gene name shown in column A. The duplicate CT values for that gene in each pool are shown along with the average CT values written in bold type with the associated standard deviation. One row below that is the calculated average DCT for that gene against GAPDH as the endogenous reference. In the blue box, each pool-by-pool comparison using GAPDH as the reference is shown along with the calculated –DDCT in column B, the relative quantitation calculated using the formula RQ = 2–DDCT in column C and the fold-change value, up or down, in column D. If the gene is upregulated, RQ is used directly but if the gene is downregulated the fold-change value is calculated as 1/RQ.  The format of the rows and columns is the same in the orange box using ACTB as the endogenous reference standard. Two different endogenous controls were employed to reduce variability that might exist between normal, hyperplastic and tumor-containing mammary tissues.  For ease of comparison, the raw numbers that generated the heat map shown in Figure 5b were extracted from the microarray data and reproduced in the yellow box. The relative quantitation (RQ), fold-change value, range and t-test p-value are shown in columns E-H, respectively. Note that the Pool no. 6 vs Pool no. 7 qRT-PCR results (last row in the blue and orange boxes) are reported here but were not shown as microarray data in Figure 5. This is because, although the trends in direction of regulation were consistent for most of the genes analyzed, the fold-change value for about 50% of the genes did not meet the twofold threshold cut off used to generate the heat map (denoted by asterisks in the yellow box)."]
[]
["gene of interest","Pool #6","Pool #2","Pool #3","Pool #1","Pool #4","Pool #5","Pool #7"]
["GAPDH",21.91,21.79,21.34,20.92,21.02,{"v":21.6,"d":"21.60"},21.88]
[null,21.99,21.85,21.56,20.91,21.01,21.65,21.78]
[null,{"v":22,"d":"22.00"},{"v":22,"d":"22.00"},21.32,21.01,21.13,21.21,{"v":21.5,"d":"21.50"}]
[null,21.82,21.91,{"v":21.3,"d":"21.30"},20.91,21.12,21.28,21.64]
[null,"21.93 +/-0.084","21.89 +/-0.090 ","21.38 +/-0.121","20.94 +/-0.049","21.07 +/-0.064","21.44 +/-0.222","21.70 +/-0.166"]
[]
["ACTB",21.27,21.02,20.54,20.94,20.35,20.72,21.81]
[null,21.34,20.89,20.37,20.68,20.29,20.62,21.85]
[null,21.48,21.21,20.64,20.83,20.71,20.27,21.49]
[null,21.41,21.32,20.64,{"v":20.7,"d":"20.70"},20.46,21.59,21.65]
[null,"21.38 +/-0.090","21.11 +/-0.192","20.55 +/-0.127","20.79 +/-0.121","20.45 +/-0.186","20.80 +/-0.561","21.70 +/-0.165"]
[]
["Rrm2",27.91,28.81,28.16,29.45,27.66,{"v":27.7,"d":"27.70"},26.97]
[null,28.03,28.81,27.99,29.42,27.61,27.63,26.83]
[null,"27.97 +/-0.085","28.81 +/-0.00","28.08 +/-0.120","29.44 +/-0.021","27.64 +/-0.035","27.66 +/-0.049","26.90 +/-0.099"]
[]
["avg DCt Rrm2-GAPDH",6.04,6.92,{"v":6.7,"d":"6.70"},{"v":8.5,"d":"8.50"},6.57,6.22,{"v":5.2,"d":"5.20"}]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-1.58,"RQ=0.334","3.0X down",{"v":0.486,"d":"0.49"},"2.0X down","2.2-1.9",0.0415]
["-DDCt Pool #3 vs. Pool #1",{"v":-1.8,"d":"-1.80"},"RQ=0.287","3.5X down",0.48,"2.1X down","2.5-1.8",0.145]
["-DDCt Pool #1 vs. Pool #4",-1.93,"RQ=0.262","3.8X down",{"v":0.244,"d":"0.24"},"4.2X down","4.3-3.9",0.0182]
["-DDCt Pool #1 vs. Pool #5",-2.28,"RQ=0.206","4.9X down",{"v":0.224,"d":"0.22"},"4.5X down","4.9-4.1",0.0379]
["-DDCt Pool #6 vs. Pool #7",-0.84,"RQ=0.559","1.8X down","*","*","*","*"]
[]
["avg DCt Rrm2-ACTB",6.59,{"v":7.7,"d":"7.70"},7.53,8.65,7.19,6.86,{"v":5.2,"d":"5.20"}]
[]
["-DDCt Pool #2 vs. Pool #1",-0.95,"RQ=0.518","1.9X down"]
["-DDCt Pool #3 vs. Pool #1",-1.12,"RQ=0.460","2.2X down"]
["-DDCt Pool #1 vs. Pool #4",-1.46,"RQ=0.363","2.8X down"]
["-DDCt Pool #1 vs. Pool #5",-1.79,"RQ=0.289","3.5X down"]
["-DDCt Pool #6 vs. Pool #7",-1.39,"RQ=0.382","2.6X down"]
[]
["Slc2a5",32.26,31.91,32.39,28.28,33.23,{"v":35,"d":"35.00"},32.37]
[null,32.27,31.82,32.23,28.25,33.33,34.67,32.08]
[null,"32.27 +/-0.007","31.87 +/-0.064","32.31 +/-0.113","28.27 +/-0.021","33.28 +/-0.071","34.84 +/-0.233","32.22 +/-0.205"]
[]
["avg DCt Slc2a5-GAPDH",10.34,9.98,10.93,7.33,12.21,{"v":13.4,"d":"13.40"},10.52]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",2.65,"RQ=6.277","6.3X up",8.52,"8.5X up","8.2-8.9",0.0116]
["-DDCt Pool #3 vs. Pool #1",{"v":3.6,"d":"3.60"},"RQ=12.12","12.1X up",12.06,"12.1X up","9.0-16.2",0.0747]
["-DDCt Pool #1 vs. Pool #4",4.88,"RQ=29.44","29.4X up",20.57,"20.6X up","18.9-22.4",0.0179]
["-DDCt Pool #1 vs. Pool #5",6.07,"RQ=67.182","67.2X up",33.99,"40X up","30.9-37.4",0.0171]
["-DDCt Pool #6 vs. Pool #7",0.18,"RQ=1.13","1.1X up","*","*","*","*"]
[]
["avg DCt Scl2a5-ACTB",10.89,10.76,11.76,7.48,12.83,14.04,10.52]
[]
["-DDCt Pool #2 vs. Pool #1",3.28,"RQ=9.714","9.7X up"]
["-DDCt Pool #3 vs. Pool #1",4.28,"RQ=19.427","19.4X up"]
["-DDCt Pool #1 vs. Pool #4",5.35,"RQ=40.786","40.8X up"]
["-DDCt Pool #1 vs. Pool #5",6.56,"RQ=94.35","94.4X up"]
["-DDCt Pool #6 vs. Pool #7",0.37,"RQ=1.292","1.3X up"]
[]
["Sncg",25.41,25.78,24.41,22.49,27.49,26.97,26.96]
[null,{"v":25.6,"d":"25.60"},25.58,24.47,22.58,27.67,{"v":26.9,"d":"26.90"},26.89]
[null,"25.51 +/-0.134","25.68 +/-0.141","24.44 +/-0.042","22.54 +/-0.064","27.58 +/-0.127","26.94 +/-0.049","26.93 +/-0.049"]
[]
["avg DCt Sncg-GAPDH",3.58,3.79,3.06,{"v":1.6,"d":"1.60"},6.51,{"v":5.5,"d":"5.50"},5.23]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",2.19,"RQ=4.563","4.6X up",{"v":4.614,"d":"4.61"},"4.6X up","4.4-4.8",0.0193]
["-DDCt Pool #3 vs. Pool #1",1.46,"RQ=2.751","2.8X up",{"v":3.249,"d":"3.25"},"3.3X up","3.2-3.3",0.0102]
["-DDCt Pool #1 vs. Pool #4",4.91,"RQ=30.065","30.1X up",15.21,"15.2X up","14.5-16.0",0.0117]
["-DDCt Pool #1 vs. Pool #5",{"v":3.9,"d":"3.90"},"RQ=14.929","15.0X up",{"v":8.004,"d":"8.00"},"8.0X up","7.6-8.4",0.0146]
["-DDCt Pool #6 vs. Pool #7",1.65,"RQ=3.138","3.2X up","*","*","*","*"]
[]
["avg DCt Sncg-ACTB",4.13,4.57,3.89,1.75,7.13,6.14,5.23]
[]
["-DDCt Pool #2 vs. Pool #1",2.82,"RQ=7.062","7.1X up"]
["-DDCt Pool #3 vs. Pool #1",2.14,"RQ=4.408","4.4X up"]
["-DDCt Pool #1 vs. Pool #4",5.38,"RQ=41.643","41.6X up"]
["-DDCt Pool #1 vs. Pool #5",4.39,"RQ=20.966","21.0X up"]
["-DDCt Pool #6 vs. Pool #7",{"v":1.1,"d":"1.10"},"RQ=2.144","2.1X up"]
[]
["Tmeff2",30.61,30.31,{"v":29,"d":"29.00"},27.63,30.99,31.01,31.81]
[null,30.57,30.29,{"v":29,"d":"29.00"},27.61,30.97,31.09,31.49]
[null,"30.59 +/-0.028","30.30 +/-0.014","29.00 +/-0.000","27.62 +/-0.014","30.98 +/-0.014","31.05 +/-0.057","31.65 +/-0.226"]
[]
[]
["avg DCt Tmeff2-GAPDH",8.66,8.41,7.62,6.68,9.91,9.61,9.95]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",1.73,"RQ=3.317","3.3X up",3.91,"3.9X up","3.7-4.1",0.0224]
["-DDCt Pool #3 vs. Pool #1",0.94,"RQ=1.919","1.9X up",2.26,"2.3X up","2.1-2.4",0.0553]
["-DDCt Pool #1 vs. Pool #4",3.23,"RQ=9.383","9.4X up",{"v":4,"d":"4.00"},"4.0X up","3.8-4.2",0.0195]
["-DDCt Pool #1 vs. Pool #5",2.93,"RQ=7.621","7.6X up",3.36,"3.4X up","3.3-3.4",0.0094]
["-DDCt Pool #6 vs. Pool #7",1.29,"RQ=2.445","2.4X up","*","*","*","*"]
[]
["avg DCt Tmeff2-ACTB",9.21,9.19,8.45,6.83,10.53,10.25,9.95]
[]
["-DDCt Pool #2 vs. Pool #1",2.36,"RQ=5.134","5.1X up"]
["-DDCt Pool #3 vs. Pool #1",1.62,"RQ=3.074","3.1X up"]
["-DDCt Pool #1 vs. Pool #4",{"v":3.7,"d":"3.70"},"RQ=12.996","13.0X up"]
["-DDCt Pool #1 vs. Pool #5",3.42,"RQ=10.703","10.7X up"]
["-DDCt Pool #6 vs. Pool #7",0.74,"RQ=1.67","1.7X up"]
[]
[]
["Ctsr",39.32,38.99,33.74,28.24,37.11,{"v":40,"d":"40.00"},{"v":40,"d":"40.00"}]
[null,38.18,38.74,34.11,28.37,37.51,39.51,39.58]
[null,"38.75 +/-0.806","38.87 +/-0.177","33.93 +/-0.262","28.31 +/-0.092","37.31 +/-0.283","39.76 +/-0.346","39.79 +/-0.297"]
[]
["avg DCt Ctsr-GAPDH",16.82,16.98,12.55,7.37,16.24,18.32,18.09]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",9.61,"RQ=781.445","781.4X up",{"v":7.759,"d":"7.76"},"7.8X","6.2-9.6",0.0675]
["-DDCt Pool #3 vs. Pool #1",5.18,"RQ=36.252","36.3X up",11.87,"11.9X","11.3-12.4",0.0117]
["-DDCt Pool #1 vs. Pool #4",8.87,"RQ=467.882","467.9X up",10.61,"10.6X","8.7-12.9",0.053]
["-DDCt Pool #1 vs. Pool #5",10.95,"RQ=1978.238","1978.2X up",13.73,"13.7X","11.6-16.2",0.0406]
["-DDCt Pool #6 vs. Pool #7",1.27,"RQ=2.412","2.4X up","*","*","*","*"]
[]
["avg DCt Ctsr-ACTB",{"v":17.4,"d":"17.40"},17.76,13.38,7.52,16.86,18.96,18.09]
[]
["-DDCt Pool #2 vs. Pool #1",10.24,"RQ=1209.336","1209.3X up"]
["-DDCt Pool #3 vs. Pool #1",5.86,"RQ=58.081","58.1X up"]
["-DDCt Pool #1 vs. Pool #4",9.34,"RQ=648.067","648.1X up"]
["-DDCt Pool #1 vs. Pool #5",11.44,"RQ=2778.326","2778.3X up"]
["-DDCt Pool #6 vs. Pool #7",0.69,"RQ=1.613","1.6X up"]
[]
["Gtse1",30.15,29.93,29.54,31.05,29.07,29.11,29.07]
[null,30.26,29.96,29.51,{"v":30.8,"d":"30.80"},28.88,29.19,29.06]
[null,"30.21 +/-0.078","29.95 +/-0.021","29.53 +/-0.021","30.93 +/-0.177","28.98 +/-0.134","29.15 +/-0.057","29.06 +/-0.007"]
[]
["avg DCt Gtse1-GAPDH",8.28,8.06,8.15,9.99,7.91,7.71,7.36]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-1.93,"RQ=0.262","3.8X down",{"v":0.428,"d":"0.43"},"2.3X down","2.6-2.1",0.0904]
["-DDCt Pool #3 vs. Pool #1",-1.84,"RQ=0.279","3.6X down",{"v":0.443,"d":"0.44"},"2.3X down","2.3-2.2",0.0175]
["-DDCt Pool #1 vs. Pool #4",-2.08,"RQ=0.237","4.2X down",{"v":0.0793,"d":"0.08"},"12.6X down","18.5-8.6",0.0949]
["-DDCt Pool #1 vs. Pool #5",-2.28,"RQ=0.206","4.9X down",{"v":0.099,"d":"0.10"},"10X down","14.9-6.8",0.106]
["-DDCt Pool #6 vs. Pool #7",-0.92,"RQ=0.529","1.9X down","*","*","*","*"]
[]
["avg DCt Gtse1-ACTB",8.83,8.84,8.98,10.14,8.53,8.35,7.36]
[]
["-DDCt Pool #2 vs. Pool #1",{"v":-1.3,"d":"-1.30"},"RQ=0.406","2.5X down"]
["-DDCt Pool #3 vs. Pool #1",-1.16,"RQ=0.448","2.2X down"]
["-DDCt Pool #1 vs. Pool #4",-1.61,"RQ=0.328","3.0X down"]
["-DDCt Pool #1 vs. Pool #5",-1.79,"RQ=0.289","3.5X down"]
["-DDCt Pool #6 vs. Pool #7",-1.47,"RQ=0.361","2.8X down"]
[]
["Cdc2a",28.51,29.44,29.05,{"v":30.8,"d":"30.80"},27.54,{"v":28.3,"d":"28.30"},27.09]
[null,28.49,29.46,29.07,{"v":30.7,"d":"30.70"},27.69,28.41,27.28]
[null,"28.50 +/-0.014","29.45 +/-0.014","29.06 +/-0.014","30.75 +/-0.071","27.62 +/-0.106","28.35 +/-0.078","27.19 +/-0.134"]
[]
["avg DCt Cdc2a-GAPDH",6.57,7.56,7.68,9.81,6.55,6.91,5.49]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-2.25,"RQ=0.210","4.8X down",{"v":0.602,"d":"0.60"},"1.7X down","1.7-1.6",0.0063]
["-DDCt Pool #3 vs. Pool #1",-2.13,"RQ=0.228","4.4X down",0.58,"1.7X down","1.7-1.6",0.0515]
["-DDCt Pool #1 vs. Pool #4",-3.26,"RQ=0.104","9.6X down",0.61,"1.6X down","1.7-1.6",0.0218]
["-DDCt Pool #1 vs. Pool #5",{"v":-2.9,"d":"-2.90"},"RQ=0.134","7.5X down",0.55,"1.8X down","1.9-1.7",0.0175]
["-DDCt Pool #6 vs. Pool #7",-1.08,"RQ=0.473","2.1X down","*","*","*","*"]
[]
["avg DCt Cdc2a-ACTB",7.12,8.34,8.51,9.96,7.17,7.55,5.49]
[]
["-DDCt Pool #2 vs. Pool #1",-1.62,"RQ=0.325","3.1X down"]
["-DDCt Pool #3 vs. Pool #1",-1.45,"RQ=0.366","2.7X down"]
["-DDCt Pool #1 vs. Pool #4",-2.79,"RQ=0.145","6.9X down"]
["-DDCt Pool #1 vs. Pool #5",-2.41,"RQ=0.188","5.3X down"]
["-DDCt Pool #6 vs. Pool #7",-1.63,"RQ=0.323","3.1X down"]
[]
["Tacc3",29.13,29.91,29.23,30.27,28.42,29.05,28.14]
[null,29.24,29.87,29.31,30.38,28.43,28.91,28.32]
[null,"29.18 +/-0.078","29.89 +/-0.028","29.27 +/-0.057","30.32 +/-0.078","28.42 +/-0.007","28.98 +/-0.099","28.23 +/-0.127"]
[]
["avg DCt Tacc3-GAPDH",7.25,{"v":8,"d":"8.00"},7.89,9.38,7.35,7.54,6.53]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-1.38,"RQ=0.384","2.6X down",{"v":0.662,"d":"0.66"},"1.5X down","1.5-1.4",0.0314]
["-DDCt Pool #3 vs. Pool #1",-1.49,"RQ=0.356","2.8X down",{"v":0.515,"d":"0.52"},"1.9X down","2.0-1.9",0.0354]
["-DDCt Pool #1 vs. Pool #4",-2.03,"RQ=0.245","4.1X down",{"v":0.212,"d":"0.21"},"4.8X down","5.1-4.4",0.0306]
["-DDCt Pool #1 vs. Pool #5",-1.84,"RQ=0.279","3.6X down",{"v":0.251,"d":"0.25"},"4.0X down","4.3-3.7",0.0309]
["-DDCt Pool #6 vs. Pool #7",-0.72,"RQ=0.607","1.6X down","*","*","*","*"]
[]
["avg DCt Tacc3-ACTB",{"v":7.8,"d":"7.80"},8.78,8.72,9.53,7.97,8.18,6.53]
[]
["-DDCt Pool #2 vs. Pool #1",-0.75,"RQ=0.595","1.7X down"]
["-DDCt Pool #3 vs. Pool #1",-0.81,"RQ=0.570","1.8X down"]
["-DDCt Pool #1 vs. Pool #4",-1.56,"RQ=0.339","3.0X down"]
["-DDCt Pool #1 vs. Pool #5",-1.35,"RQ=0.392","2.6X down"]
["-DDCt Pool #6 vs. Pool #7",-1.27,"RQ=0.415","2.4X down"]
[]
["Cops4",25.68,26.11,24.52,22.81,28.18,{"v":27.1,"d":"27.10"},27.01]
[null,25.96,26.06,24.47,22.85,28.22,27.21,26.89]
[null,"25.82 +/-0.198","26.08 +/-0.035","24.50 +/-0.035","22.83 +/-0.028","28.20 +/-0.028","27.16 +/-0.078","26.95 +/-0.085"]
[]
["avg DCt Cops4-GAPDH",3.89,4.19,3.12,1.89,7.13,5.72,5.25]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",{"v":2.3,"d":"2.30"},"RQ=4.925","4.9X up",{"v":3.117,"d":"3.12"},"3.1X up","2.8-3.4",0.0493]
["-DDCt Pool #3 vs. Pool #1",1.23,"RQ=2.346","2.3X up",{"v":2.183,"d":"2.18"},"2.2X up","2.0-2.3",0.0545]
["-DDCt Pool #1 vs. Pool #4",5.24,"RQ=37.792","37.8X up",{"v":4.359,"d":"4.36"},"4.4X up","3.9-4.8",0.0431]
["-DDCt Pool #1 vs. Pool #5",3.83,"RQ=14.123","14.1X up",{"v":3.332,"d":"3.33"},"3.3X up","2.9-3.8",0.0698]
["-DDCt Pool #6 vs. Pool #7",1.36,"RQ=2.567","2.6X up","*","*","*","*"]
[]
["avg DCt Cops4-ACTB",4.44,4.97,3.95,2.04,7.75,6.36,5.25]
[]
["-DDCt Pool #2 vs. Pool #1",2.93,"RQ=7.621","7.6X up"]
["-DDCt Pool #3 vs. Pool #1",1.91,"RQ=3.758","3.8X up"]
["-DDCt Pool #1 vs. Pool #4",5.71,"RQ=52.346","52.3X up"]
["-DDCt Pool #1 vs. Pool #5",4.32,"RQ=19.973","20X up"]
["-DDCt Pool #6 vs. Pool #7",0.81,"RQ=1.753","1.8X up"]
[]
["Cops5",31.24,31.01,{"v":29.7,"d":"29.70"},28.37,{"v":31.6,"d":"31.60"},31.33,31.77]
[null,31.35,30.98,29.64,28.35,31.61,31.35,31.81]
[null,"31.30 +/-0.078","31.00 +/-0.021","29.67 +/-0.042","28.36 +/-0.014","31.61 +/- 0.007","31.34 +/-0.014","31.79 +/-0.028"]
[]
["avg DCt Cops5-GAPDH",9.37,9.11,8.29,7.42,10.54,{"v":9.9,"d":"9.90"},10.09]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",1.69,"RQ=3.227","3.2X up",{"v":2.482,"d":"2.48"},"2.5X up","2.3-2.6",0.0454]
["-DDCt Pool #3 vs. Pool #1",0.87,"RQ=1.828","1.8X up",{"v":2.023,"d":"2.02"},"2.0X up","1.9-2.2",0.0636]
["-DDCt Pool #1 vs. Pool #4",3.12,"RQ=8.694","8.7X  up",{"v":3.907,"d":"3.91"},"3.9X up","3.7-4.1",0.0237]
["-DDCt Pool #1 vs. Pool #5",2.48,"RQ=5.579","5.6X up",{"v":3.288,"d":"3.29"},"3.3X up","3.1-3.4",0.0236]
["-DDCt Pool #6 vs. Pool #7",0.72,"RQ=1.647","1.6X up","*","*","*","*"]
[]
["avg DCt Cops5-ACTB",9.92,9.89,9.12,7.57,11.16,10.54,10.09]
[]
["-DDCt Pool #2 vs. Pool #1",2.32,"RQ=4.993","5.0X up"]
["-DDCt Pool #3 vs. Pool #1",1.55,"RQ=2.928","2.9X up"]
["-DDCt Pool #1 vs. Pool #4",3.59,"RQ=12.042","12.0X up"]
["-DDCt Pool #1 vs. Pool #5",2.97,"RQ=7.835","7.8X up"]
["-DDCt Pool #6 vs. Pool #7",0.17,"RQ=1.125","1.1X up"]
[]
["Top2a",27.23,27.65,26.96,28.33,26.13,26.33,25.33]
[null,27.28,27.62,26.93,28.33,26.04,26.33,25.32]
[null,"27.26 +/-0.035","27.64 +/-0.021","26.94 +/-0.021","28.33 +/-0.000","26.08 +/-0.064","26.33 +/-0.000","25.32 +/-0.007"]
[]
["avg DCt Top2a-GAPDH",5.33,5.75,5.56,7.39,5.01,4.89,3.62]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-1.64,"RQ=0.321","3.1X down",{"v":0.647,"d":"0.65"},"1.5X down","1.6-1.5",0.0658]
["-DDCt Pool #3 vs. Pool #1",-1.83,"RQ=0.281","3.6X down",{"v":0.652,"d":"0.65"},"1.5X down","1.6-1.5",0.0053]
["-DDCt Pool #1 vs. Pool #4",-2.38,"RQ=0.192","5.2X down",{"v":0.321,"d":"0.32"},"3.1X down","3.2-3.0",0.0195]
["-DDCt Pool #1 vs. Pool #5",{"v":-2.5,"d":"-2.50"},"RQ=0.177","5.6X down",{"v":0.357,"d":"0.36"},"2.8X down","3.0-2.6",0.05]
["-DDCt Pool #6 vs. Pool #7",-1.71,"RQ=0.306","3.3X down","*","*","*","*"]
[]
["avg DCt Top2a-ACTB",5.88,6.53,6.39,7.54,5.63,5.53,3.62]
[]
["-DDCt Pool #2 vs. Pool #1",-1.01,"RQ=0.497","2.0X down"]
["-DDCt Pool #3 vs. Pool #1",-1.15,"RQ=0.451","2.2X down"]
["-DDCt Pool #1 vs. Pool #4",-1.91,"RQ=0.266","3.8X down"]
["-DDCt Pool #1 vs. Pool #5",-2.01,"RQ=0.248","4.0X down"]
["-DDCt Pool #6 vs. Pool #7",-2.26,"RQ=0.209","4.8X down"]
[]
["Cenpa",31.52,{"v":32.3,"d":"32.30"},32.25,32.92,29.75,29.57,30.52]
[null,31.53,32.11,31.85,33.08,29.77,29.56,30.61]
[null,"31.52 +/-0.007","32.20 +/-0.134","32.05 +/-0.283","33.00 +/-0.113","29.76 +/-0.014","29.56 +/-0.007","30.56 +/-0.064"]
[]
["avg DCt Cenpa-GAPDH",9.59,10.31,10.67,12.06,8.69,8.12,8.86]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-1.75,"RQ=0.297","3.4X down",0.65,"1.5X down","1.6-1.4",0.0732]
["-DDCt Pool #3 vs. Pool #1",-1.39,"RQ=0.382","2.6X down",{"v":0.556,"d":"0.56"},"1.8X down","1.8-1.7",0.026]
["-DDCt Pool #1 vs. Pool #4",-3.37,"RQ=0.097","10.3X down",{"v":0.349,"d":"0.35"},"2.9X down","3.1-2.6",0.0581]
["-DDCt Pool #1 vs. Pool #5",-3.94,"RQ=0.065","15.4X down",{"v":0.335,"d":"0.34"},"3.0X down","3.1-2.8",0.0278]
["-DDCt Pool #6 vs. Pool #7",-0.73,"RQ=0.603","1.6X down","*","*","*","*"]
[]
["avg DCt Cenpa-ACTB",10.14,11.09,{"v":11.5,"d":"11.50"},12.21,9.31,8.76,8.86]
[]
["-DDCt Pool #2 vs. Pool #1",-1.12,"RQ=0.460","2.2X down"]
["-DDCt Pool #3 vs. Pool #1",-0.71,"RQ=0.611","1.6X down"]
["-DDCt Pool #1 vs. Pool #4",{"v":-2.9,"d":"-2.90"},"RQ=0.134","7.5X down"]
["-DDCt Pool #1 vs. Pool #5",-3.45,"RQ=0.092","10.9X down"]
["-DDCt Pool #6 vs. Pool #7",-1.28,"RQ=0.412","2.4X down"]
[]
["Slc2a4",26.13,26.31,{"v":25.2,"d":"25.20"},23.78,{"v":28.5,"d":"28.50"},27.33,26.77]
[null,26.41,{"v":26.3,"d":"26.30"},25.34,23.62,28.83,27.32,26.81]
[null,"26.27 +/-0.198","26.30 +/-0.007","25.27 +/-0.099","23.70 +/-0.113","28.66 +/-0.233","27.32 +/-0.007","26.79 +/-0.028"]
[]
["avg DCt Slc2a4-GAPDH",4.34,4.41,3.89,2.76,7.59,5.88,5.09]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",1.65,"RQ=3.138","3.1X up",3.99,"4.0X up","3.9-4.0",0.0058]
["-DDCt Pool #3 vs. Pool #1",1.13,"RQ=2.189","2.2X up",{"v":3.402,"d":"3.40"},"3.4X up","3.3-3.5",0.0123]
["-DDCt Pool #1 vs. Pool #4",4.83,"RQ=28.443","28.4X up",13.12,"13.1X up","12.2-14.1",0.0172]
["-DDCt Pool #1 vs. Pool #5",3.12,"RQ=8.694","8.7X up",{"v":7.493,"d":"7.49"},"7.5X up","7.2-7.8",0.0114]
["-DDCt Pool #6 vs. Pool #7",0.75,"RQ=1.682","1.7X up","*","*","*","*"]
[]
["avg DCt Slc2a4-ACTB",4.89,5.19,4.72,2.91,8.21,6.52,5.09]
[]
["-DDCt Pool #2 vs. Pool #1",2.28,"RQ=4.857","4.9X up"]
["-DDCt Pool #3 vs. Pool #1",1.81,"RQ=3.506","3.5X up"]
["-DDCt Pool #1 vs. Pool #4",{"v":5.3,"d":"5.30"},"RQ=39.397","39.4X up"]
["-DDCt Pool #1 vs. Pool #5",3.61,"RQ=12.210","12.2X up"]
["-DDCt Pool #6 vs. Pool #7",{"v":0.2,"d":"0.20"},"RQ=1.149","1.1X up"]
[]
["Gsn",22.96,23.72,21.27,20.24,24.78,23.04,23.73]
[null,22.85,23.57,{"v":21.3,"d":"21.30"},20.31,24.84,22.96,23.51]
[null,"22.90 +/-0.078","23.64 +/-0.106","21.28 +/-0.021","20.28 +/-0.049","24.81 +/-0.042","23.00 +/-0.057","23.62 +/-0.156"]
[]
["avg DCt Gsn-GAPDH",1.97,2.75,{"v":0.9,"d":"0.90"},0.34,4.74,2.56,2.92]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",2.41,"RQ=5.315","5.3X up",{"v":5.135,"d":"5.14"},"5.1X up","4.6-5.7",0.0388]
["-DDCt Pool #3 vs. Pool #1",0.56,"RQ=1.474","1.5X up",2.41,"2.4X up","1.8-3.2",0.206]
["-DDCt Pool #1 vs. Pool #4",{"v":4.4,"d":"4.40"},"RQ=21.112","21.1X up",8.98,"9.0X up","8.8-9.2",0.0055]
["-DDCt Pool #1 vs. Pool #5",2.22,"RQ=4.659","4.7X up",{"v":4.917,"d":"4.92"},"4.9X up","4.7-5.1",0.0158]
["-DDCt Pool #6 vs. Pool #7",0.95,"RQ=1.932","1.9X up","*","*","*","*"]
[]
["avg DCt Gsn-ACTB",2.52,3.53,1.73,0.49,5.36,{"v":3.2,"d":"3.20"},2.92]
[]
["-DDCt Pool #2 vs. Pool #1",3.04,"RQ=8.22","8.2X up"]
["-DDCt Pool #3 vs. Pool #1",1.24,"RQ=2.362","2.4X up"]
["-DDCt Pool #1 vs. Pool #4",4.87,"RQ=29.243","29.2X up"]
["-DDCt Pool #1 vs. Pool #5",2.71,"RQ=6.543","6.5X up"]
["-DDCt Pool #6 vs. Pool #7",{"v":0.4,"d":"0.40"},"RQ=1.32","1.3X up"]
[]
["Ntng1",31.64,31.84,30.42,29.44,32.79,32.34,32.08]
[null,31.53,31.99,{"v":30.5,"d":"30.50"},29.63,32.86,32.44,32.32]
[null,"31.58 +/-0.078","31.92 +/-0.106","30.46 +/-0.057","29.54 +/-0.134","32.82 +/-0.049","32.39 +/-0.071","32.20 +/-0.170"]
[]
["avg DCt Ntng1-GAPDH",9.65,10.03,9.08,{"v":8.6,"d":"8.60"},11.75,10.95,{"v":10.5,"d":"10.50"}]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",1.43,"RQ=2.694","2.7X up",{"v":3.1,"d":"3.10"},"3.1X up","2.0-3.6",0.0022]
["-DDCt Pool #3 vs. Pool #1",0.48,"RQ=1.395","1.4X up",2.03,"2.0X up","1.4-2.6",0.0006]
["-DDCt Pool #1 vs. Pool #4",3.15,"RQ=8.877","8.9X up",{"v":3,"d":"3.00"},"3.0X up","1.9-3.7",0.0375]
["-DDCt Pool #1 vs. Pool #5",2.35,"RQ=5.098","5.1X up",2.72,"2.7X up","1.5-4.1",0.0168]
["-DDCt Pool #6 vs. Pool #7",0.85,"RQ=1.803","1.8X up","*","*","*","*"]
[]
["avg DCt Ntng1-ACTB",{"v":10.2,"d":"10.20"},10.81,9.91,8.75,12.37,11.94,{"v":10.5,"d":"10.50"}]
[]
["-DDCt Pool #2 vs. Pool #1",2.06,"RQ=4.170","4.2X up"]
["-DDCt Pool #3 vs. Pool #1",1.16,"RQ=2.235","2.2X up"]
["-DDCt Pool #1 vs. Pool #4",3.62,"RQ=12.295","12.3X up"]
["-DDCt Pool #1 vs. Pool #5",3.19,"RQ=9.126","9.1X up"]
["-DDCt Pool #6 vs. Pool #7",{"v":0.3,"d":"0.30"},"RQ=1.231","1.2X up"]
[]
["Cdkn1a",29.49,{"v":28,"d":"28.00"},29.02,30.08,27.49,27.52,{"v":29,"d":"29.00"}]
[null,29.61,28.09,28.88,29.98,27.86,{"v":27.6,"d":"27.60"},28.79]
[null,"29.55 +/-0.085","28.04 +/-0.064","28.95 +/-0.099","30.03 +/-0.071","27.68 +/-0.262","27.56 +/-0.057","28.90 +/-0.148"]
[]
["avg DCt Cdkn1a-GAPDH",7.62,6.15,7.57,9.09,6.61,6.12,{"v":7.2,"d":"7.20"}]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-2.94,"RQ=0.130","7.7X down",{"v":0.395,"d":"0.40"},"2.5X down","2.8-2.3",0.0779]
["-DDCt Pool #3 vs. Pool #1",-1.52,"RQ=0.349","2.9X down",{"v":0.606,"d":"0.61"},"1.6X down","1.7-1.6",0.0658]
["-DDCt Pool #1 vs. Pool #4",-2.48,"RQ=0.179","5.6X down",{"v":0.367,"d":"0.37"},"2.7X down","2.8-2.7",0.0137]
["-DDCt Pool #1 vs. Pool #5",-2.97,"RQ=0.128","7.8X down",{"v":0.333,"d":"0.33"},"3.0X down","3.2-2.8",0.0439]
["-DDCt Pool #6 vs. Pool #7",-0.42,"RQ=0.747","1.3X down","*","*","*","*"]
[]
["avg DCt Cdkn1a-ACTB",8.17,6.93,{"v":8.4,"d":"8.40"},9.24,7.23,6.76,{"v":7.2,"d":"7.20"}]
[]
["-DDCt Pool #2 vs. Pool #1",-2.31,"RQ=0.202","4.9X down"]
["-DDCt Pool #3 vs. Pool #1",-0.84,"RQ=0.559","1.8X down"]
["-DDCt Pool #1 vs. Pool #4",-2.01,"RQ=0.248","4.0X down"]
["-DDCt Pool #1 vs. Pool #5",-2.48,"RQ=0.179","5.6X down"]
["-DDCt Pool #6 vs. Pool #7",-0.97,"RQ=0.511","2.0X down"]
[]
["Rspondin",{"v":27.8,"d":"27.80"},{"v":27.9,"d":"27.90"},{"v":27.3,"d":"27.30"},{"v":27.1,"d":"27.10"},27.85,27.85,27.39]
[null,27.87,27.97,27.42,27.15,27.86,27.92,27.43]
[null,"27.84 +/-0.049","27.93 +/-0.049","27.36 +/-0.085","27.12 +/-0.035","27.83 +/-0.042","27.89 +/-0.049","27.41 +/-0.028"]
[]
["avg DCt Cops4-GAPDH",5.91,6.04,5.98,6.18,6.76,6.45,5.71]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",-0.14,"RQ=0.908","1.1X down",{"v":0.543,"d":"0.54"},"1.9X down","2.3-1.5",0.233]
["-DDCt Pool #3 vs. Pool #1",{"v":-0.2,"d":"-0.20"},"RQ=0.871","1.1X down",{"v":0.481,"d":"0.48"},"2.1X down","2.7-1.6",0.216]
["-DDCt Pool #1 vs. Pool #4",0.58,"RQ=1.495","1.5X up",{"v":4.057,"d":"4.06"},"4.0X up","4.0-4.1",0.0086]
["-DDCt Pool #1 vs. Pool #5",0.27,"RQ=1.206","1.2X up",15.47,"15.5X up","15.4-15.5",0.0002]
["-DDCt Pool #6 vs. Pool #7",{"v":-0.2,"d":"-0.20"},"RQ=0.871","1.1X down","*","*","*","*"]
[]
["avg DCt Cops4-ACTB",6.04,6.82,6.81,6.33,7.38,7.09,5.71]
[]
["-DDCt Pool #2 vs. Pool #1",0.49,"RQ=1.404","1.4X up"]
["-DDCt Pool #3 vs. Pool #1",0.48,"RQ=1.395","1.4X up"]
["-DDCt Pool #1 vs. Pool #4",1.05,"RQ=2.071","2.1X up"]
["-DDCt Pool #1 vs. Pool #5",0.76,"RQ=1.693","1.7X up"]
["-DDCt Pool #6 vs. Pool #7",-0.33,"RQ=0.796","1.3X down"]
[]
["Hmgb2",25.33,25.13,25.44,25.66,25.29,25.14,25.27]
[null,25.31,25.03,25.42,{"v":25.4,"d":"25.40"},25.27,25.12,25.34]
[null,"25.32 +/-0.014","25.08 +/-0.071","25.43 +/-0.014","25.53 +/-0.184","25.28+/-0.014","25.13 +/-0.014","25.30 +/-0.049"]
[]
["avg DCt Cops5-GAPDH",3.39,3.19,4.05,4.59,4.21,3.69,{"v":3.6,"d":"3.60"}]
[]
[{"$nulls":4},"MICROARRAY (RQ)","FOLD CHANGE","RANGE","T-TEST p-value"]
["-DDCt Pool #2 vs. Pool #1",{"v":-1.4,"d":"-1.40"},"RQ=0.379","2.6X down",{"v":0.655,"d":"0.66"},"1.5X down","1.6-1.5",0.0617]
["-DDCt Pool #3 vs. Pool #1",-0.54,"RQ=0.688","1.4X down",{"v":0.567,"d":"0.57"},"1.8X down","1.8-1.7",0.0165]
["-DDCt Pool #1 vs. Pool #4",-0.38,"RQ=0.768","1.3X down",{"v":0.255,"d":"0.26"},"3.9X down","4.1-3.7",0.023]
["-DDCt Pool #1 vs. Pool #5",{"v":-0.9,"d":"-0.90"},"RQ=0.536","1.9X down",{"v":0.276,"d":"0.28"},"3.6X down","4.0-3.2",0.0539]
["-DDCt Pool #6 vs. Pool #7",0.21,"RQ=1.157","1.1X up","*","*","*","*"]
[]
["avg DCt Cops5-ACTB",3.94,3.97,4.88,4.74,4.83,4.33,{"v":3.6,"d":"3.60"}]
[]
["-DDCt Pool #2 vs. Pool #1",-0.77,"RQ=0.586","1.7X down"]
["-DDCt Pool #3 vs. Pool #1",0.14,"RQ=1.102","1.1X up"]
["-DDCt Pool #1 vs. Pool #4",0.09,"RQ=1.064","1.1X up"]
["-DDCt Pool #1 vs. Pool #5",-0.41,"RQ=0.753","1.3X down"]
["-DDCt Pool #6 vs. Pool #7",-0.34,"RQ=0.790","1.3X down"]

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}