TI  - Crystal structure of human <prot>platelet-derived growth factor BB</prot>.
PG  - 3921-6
AB  - The crystal structure of the homodimeric <prot>BB isoform of   human recombinant
      platelet-derived growth factor</prot> (<prot>PDGF-BB</prot>)   has been determined by X-ray
      analysis to 3.0 A resolution. The polypeptide chain is folded into two
      highly twisted antiparallel pairs of beta-strands and contains an unusual
      knotted arrangement of three intramolecular disulfide bonds. Dimerization
      leads to the clustering of three surface loops at each end of the
      elongated dimer, which most probably form the receptor recognition sites.
AD  - Department of Pharmaceutical Research--New Technologies, F. Hoffmann-La
