{"text_format":"3","workbook":"xls","n_sheets":2,"sheets":["Ausubel_ADF4","ADF4_Legend"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1904","formulas":"cached_only"}

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["Strain","Strain Specific Region ID","Corresponding Region in Other Strain","Region Start","Region Stop","Region Size","Total Genes","Strain Specific Genes","Polymorphisms","Orthologs","Duplications","Translocations","Split or Fused ORFs","Class 1 Genes","Class 2 Genes","Class 3 Genes","Class 4 Genes","Method Used to Define Region"]
["PA14","PA14R01","PAO1R01",51628,54699,3072,2,1,1,{"$nulls":6},1,1,"NUCmer"]
["PA14","PA14R02","PAO1R02",67074,67187,114,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R03","PAO1R03",110941,111828,888,3,1,2,{"$nulls":7},3,"NUCmer"]
["PA14","PA14R04","PAO1R04",118556,120196,1641,2,1,1,{"$nulls":7},2,"NUCmer"]
["PA14","PA14R05","PAO1R05",162378,163313,936,1,1,{"$nulls":7},1,null,"NUCmer"]
["PA14","PA14R06","PAO1R06",212262,212262,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R07","PAO1R07",227272,227313,42,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R08","PAO1R08",278151,280853,2703,4,2,null,null,2,{"$nulls":5},4,"NUCmer and Manual Edits"]
["PA14","PA14R09","PAO1R09",290260,312955,22696,16,14,{"$nulls":3},2,{"$nulls":3},1,15,"NUCmer and Manual Edits"]
["PA14","PA14R10","PAO1R10",418481,419135,655,1,1,{"$nulls":8},1,"NUCmer and Manual Edits"]
["PA14","PA14R11","PAO1R11",514454,514454,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R12","PAO1R12",528938,528938,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R13","PAO1R13",533749,533749,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R14","PAO1R14",569099,569467,369,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R15","PAO1R15",640117,643335,3219,2,2,{"$nulls":7},1,1,"NUCmer and Manual Edits"]
["PA14","PA14R16","PAO1R16",685280,685280,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R17","PAO1R17",707399,712760,5362,3,null,1,2,{"$nulls":5},2,1,"NUCmer and Manual Edits"]
["PA14","PA14R18","PAO1R76",833828,833828,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R19","PAO1R75",864336,869609,5274,6,6,{"$nulls":7},4,2,"NUCmer"]
["PA14","PA14R20","PAO1R74",936797,938793,1997,2,2,{"$nulls":7},2,null,"NUCmer"]
["PA14","PA14R21","PAO1R73",947382,950523,3142,3,3,{"$nulls":7},1,2,"NUCmer"]
["PA14","PA14R22","PAO1R72",997695,997695,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R23","PAO1R71",1051334,1051425,92,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R24","PAO1R70",1107072,1107251,180,1,1,{"$nulls":8},1,"Manual Edits"]
["PA14","PA14R25","PAO1R69",1136925,1138710,1786,3,3,{"$nulls":7},1,2,"NUCmer"]
["PA14","PA14R26","PAO1R68",1220045,1223012,2968,4,3,null,1,{"$nulls":5},3,1,"NUCmer and Manual Edits"]
["PA14","PA14R27","PAO1R67",1228936,1231584,2649,3,2,1,{"$nulls":7},3,"NUCmer and Manual Edits"]
["PA14","PA14R28","PAO1R66",1243652,1244659,1008,3,3,{"$nulls":8},3,"NUCmer"]
["PA14","PA14R29","PAO1R65",1300821,1332436,31616,31,31,{"$nulls":6},8,9,14,"NUCmer"]
["PA14","PA14R30","PAO1R64",1627376,1627522,147,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R31","PAO1R63",1666986,1666986,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R32","PAO1R62",1666986,1666986,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R33","PAO1R61",1697397,1697397,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R34","PAO1R60",1760612,1767943,7332,3,2,null,null,1,{"$nulls":5},3,"NUCmer and Manual Edits"]
["PA14","PA14R35","PAO1R59",1772628,1773859,1232,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R36","PAO1R58",1918863,1941368,21861,19,17,{"$nulls":4},2,null,null,2,17,"NUCmer and Manual Edits"]
["PA14","PA14R37","PAO1R57",1957918,1962854,4937,6,6,{"$nulls":7},4,2,"NUCmer"]
["PA14","PA14R38","PAO1R56",2026259,2041607,15349,12,12,{"$nulls":5},1,null,7,4,"NUCmer"]
["PA14","PA14R39","PAO1R55",2117455,2120706,3252,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R40","PAO1R54",2135089,2135245,157,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R41","PAO1R53",2395850,2402720,6871,8,8,{"$nulls":7},2,6,"NUCmer"]
["PA14","PA14R42","PAO1R52",2442764,2444812,1570,4,4,{"$nulls":7},1,3,"NUCmer and Manual Edits"]
["PA14","PA14R43","PAO1R51",2474588,2492547,17960,12,10,null,null,2,{"$nulls":4},2,10,"NUCmer and Manual Edits"]
["PA14","PA14R44","PAO1R50",2504707,2506644,1938,2,2,{"$nulls":8},2,"NUCmer"]
["PA14","PA14R45","PAO1R49",2537007,2538476,1470,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R46","PAO1R48",2658778,2661114,2337,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R47","PAO1R47",2677702,2721390,43689,39,39,{"$nulls":7},19,20,"NUCmer"]
["PA14","PA14R48","PAO1R46",2858836,2876554,17719,6,4,1,null,1,{"$nulls":5},6,"NUCmer and Manual Edits"]
["PA14","PA14R49","PAO1R45",2926336,2937212,10877,8,7,null,1,{"$nulls":5},1,7,"NUCmer"]
["PA14","PA14R50","PAO1R44",3019429,3021349,1921,2,2,{"$nulls":8},2,"NUCmer"]
["PA14","PA14R51","PAO1R43",3063621,3063760,140,0,{"$nulls":10},"NUCmer"]
["PA14","PA14R52","PAO1R42",3078818,3078818,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R53","PAO1R41",3108422,3108422,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R54","PAO1R40",3174604,3209910,35307,31,31,{"$nulls":6},2,14,15,"NUCmer"]
["PA14","PA14R55","PAO1R39",3236380,3239230,2851,4,null,2,2,{"$nulls":3},1,null,2,1,"NUCmer and Manual Edits"]
["PA14","PA14R56","PAO1R38",3249895,3249995,101,0,{"$nulls":10},"NUCmer"]
["PA14","PA14R57","PAO1R37",3311009,3312129,1121,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R58","PAO1R36",3324986,3325084,99,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R59","PAO1R35",3356473,3356473,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R60","PAO1R34",3511632,3515709,4078,2,2,{"$nulls":8},2,"NUCmer"]
["PA14","PA14R61","PAO1R33",3615170,3616807,1638,1,1,{"$nulls":7},1,null,"NUCmer"]
["PA14","PA14R62","PAO1R32",3831764,3840946,9183,4,2,null,null,2,{"$nulls":3},1,null,3,"NUCmer"]
["PA14","PA14R63","PAO1R31",3974637,3975626,990,0,{"$nulls":10},"NUCmer"]
["PA14","PA14R64","PAO1R30",3999659,3999791,133,0,{"$nulls":10},"NUCmer"]
["PA14","PA14R65","PAO1R29",4044735,4045251,517,0,{"$nulls":10},"NUCmer"]
["PA14","PA14R66","PAO1R28",4127902,4128119,218,0,{"$nulls":10},"NUCmer"]
["PA14","PA14R67","PAO1R27",4133029,4135104,2076,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R68","PAO1R26",4138567,4155629,17063,13,12,null,1,{"$nulls":5},8,5,"NUCmer and Manual Edits"]
["PA14","PA14R69","PAO1R25",4306736,4312390,5253,7,6,1,{"$nulls":6},6,1,"NUCmer and Manual Edits"]
["PA14","PA14R70","PAO1R24",4345136,4355790,10655,16,4,0,null,null,12,null,2,null,1,13,"NUCmer and Manual Edits"]
["PA14","PA14R71","PAO1R23",4399106,4407272,8167,6,4,1,1,{"$nulls":3},2,null,null,4,"NUCmer and Manual Edits"]
["PA14","PA14R72","PAO1R22",4580255,4590346,10092,14,10,null,4,{"$nulls":3},2,null,4,8,"NUCmer and Manual Edits"]
["PA14","PA14R73","PAO1R21",4750136,4755831,5696,5,5,{"$nulls":7},1,4,"NUCmer"]
["PA14","PA14R74","PAO1R20",4793721,4794244,524,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R75","PAO1R19",4860217,4895069,34853,23,21,null,null,2,{"$nulls":4},12,11,"NUCmer"]
["PA14","PA14R76","PAO1R18",4919106,4931711,12606,2,1,1,{"$nulls":7},2,"NUCmer"]
["PA14","PA14R77","PAO1R77",5232717,5236786,4070,5,3,1,1,{"$nulls":3},3,null,null,2,"NUCmer and Manual Edits"]
["PA14","PA14R78","PAO1R78",5251491,5359387,107897,114,111,{"$nulls":3},3,null,2,6,28,78,"NUCmer and Manual Edits"]
["PA14","PA14R79","PAO1R79",5369924,5377451,7528,5,2,3,{"$nulls":4},3,2,null,null,"NUCmer"]
["PA14","PA14R80","PAO1R80",5654192,5654192,1,0,{"$nulls":10},"Manual Edits"]
["PA14","PA14R81","PAO1R81",5657279,5658395,1117,2,2,{"$nulls":7},1,1,"NUCmer"]
["PA14","PA14R82","PAO1R82",5739734,5740523,790,1,1,{"$nulls":8},1,"NUCmer"]
["PA14","PA14R83","PAO1R83",5998829,5999598,770,1,null,1,{"$nulls":7},1,"NUCmer"]
["PA14","PA14R84","PAO1R84",6198205,6203977,5773,3,3,{"$nulls":8},3,"NUCmer"]
["PA14","PA14R85","PAO1R85",6261360,6261551,192,1,1,{"$nulls":8},1,"Manual Edits"]
["PAO1","PAO1R01","PA14R01",51608,56087,4480,1,null,1,{"$nulls":6},1,null,"NUCmer and Manual Edits"]
["PAO1","PAO1R02","PA14R02",68712,69536,825,1,1,{"$nulls":8},1,"NUCmer"]
["PAO1","PAO1R03","PA14R03",113288,113846,559,2,null,2,{"$nulls":7},2,"NUCmer"]
["PAO1","PAO1R04","PA14R04",120574,122281,1708,2,1,1,{"$nulls":7},2,"NUCmer"]
["PAO1","PAO1R05","PA14R05",164417,164460,44,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R06","PA14R06",213412,215536,2125,2,2,{"$nulls":8},2,"NUCmer"]
["PAO1","PAO1R07","PA14R07",230536,237162,6627,6,6,{"$nulls":7},6,null,"NUCmer"]
["PAO1","PAO1R08","PA14R08",288335,289504,1170,2,2,{"$nulls":8},2,"NUCmer"]
["PAO1","PAO1R09","PA14R09",297561,297561,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R10","PA14R10",404320,404383,64,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R11","PA14R11",499829,501219,1391,1,1,{"$nulls":7},1,null,"NUCmer"]
["PAO1","PAO1R12","PA14R12",515761,516028,268,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R13","PA14R13",521401,521595,195,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R14","PA14R14",556314,559494,3181,3,3,{"$nulls":7},1,2,"NUCmer"]
["PAO1","PAO1R15","PA14R15",629884,629884,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R16","PA14R16",672584,672714,131,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R17","PA14R17",694709,701776,7068,7,4,1,2,{"$nulls":5},2,5,"NUCmer"]
["PAO1","PAO1R18","PA14R76",747566,761292,13727,3,2,1,{"$nulls":5},1,null,2,"NUCmer"]
["PAO1","PAO1R19","PA14R75",785329,797720,12392,15,3,{"$nulls":3},12,null,2,null,2,11,"NUCmer and Manual Edits"]
["PAO1","PAO1R20","PA14R74",863771,863806,36,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R21","PA14R73",901046,901046,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R22","PA14R72",1061207,1065389,4183,6,1,null,4,null,1,{"$nulls":4},6,"NUCmer and Manual Edits"]
["PAO1","PAO1R23","PA14R71",1242669,1249906,7238,6,4,1,1,{"$nulls":3},2,null,null,4,"NUCmer and Manual Edits"]
["PAO1","PAO1R24","PA14R70",1293164,1293267,104,0,{"$nulls":10},"NUCmer and Manual Edits"]
["PAO1","PAO1R25","PA14R69",1326048,1327860,1813,3,2,1,{"$nulls":6},3,null,"NUCmer and Manual Edits"]
["PAO1","PAO1R26","PA14R68",1478862,1489617,10756,7,6,null,1,{"$nulls":6},7,"NUCmer"]
["PAO1","PAO1R27","PA14R67",1493055,1493055,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R28","PA14R66",1497986,1516316,18331,13,13,{"$nulls":6},2,6,5,"NUCmer"]
["PAO1","PAO1R29","PA14R65",1598963,1600080,1118,2,2,{"$nulls":8},2,"NUCmer"]
["PAO1","PAO1R30","PA14R64",1644725,1644725,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R31","PA14R63",1668832,1668832,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R32","PA14R62",1802527,1803050,524,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R33","PA14R61",2017851,2017967,117,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R34","PA14R60",2116708,2122578,5871,5,3,{"$nulls":3},2,{"$nulls":4},5,"NUCmer and Manual Edits"]
["PAO1","PAO1R35","PA14R59",2277497,2279839,2343,2,2,{"$nulls":7},1,1,"NUCmer and Manual Edits"]
["PAO1","PAO1R36","PA14R58",2311108,2318222,7115,7,7,{"$nulls":7},4,3,"NUCmer"]
["PAO1","PAO1R37","PA14R57",2330963,2332387,1425,1,1,{"$nulls":6},1,null,null,"NUCmer"]
["PAO1","PAO1R38","PA14R56",2393399,2393608,210,1,1,{"$nulls":8},1,"NUCmer"]
["PAO1","PAO1R39","PA14R55",2404281,2412345,8065,12,8,2,2,{"$nulls":3},1,1,1,9,"NUCmer and Manual Edits"]
["PAO1","PAO1R40","PA14R54",2439015,2458238,19224,17,17,{"$nulls":5},1,null,6,1,"NUCmer"]
["PAO1","PAO1R41","PA14R53",2524379,2527240,2862,3,3,{"$nulls":7},2,1,"NUCmer"]
["PAO1","PAO1R42","PA14R52",2556869,2558584,1716,1,1,{"$nulls":7},1,null,"NUCmer"]
["PAO1","PAO1R43","PA14R51",2574394,2580969,6576,4,4,{"$nulls":7},3,1,"NUCmer"]
["PAO1","PAO1R44","PA14R50",2623253,2624365,1113,1,1,{"$nulls":8},1,"NUCmer"]
["PAO1","PAO1R45","PA14R49",2706352,2706457,106,1,null,null,1,{"$nulls":6},1,"NUCmer"]
["PAO1","PAO1R46","PA14R48",2756239,2767290,11052,7,5,1,null,1,{"$nulls":5},7,"NUCmer and Manual Edits"]
["PAO1","PAO1R47","PA14R47",2905550,2905550,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R48","PA14R46",2922598,2923150,553,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R49","PA14R45",3043435,3044949,1515,1,1,{"$nulls":7},1,null,"NUCmer"]
["PAO1","PAO1R50","PA14R44",3075326,3075381,56,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R51","PA14R43",3087536,3099261,11726,7,7,{"$nulls":7},1,6,"NUCmer"]
["PAO1","PAO1R52","PA14R42",3129637,3131505,1869,2,2,{"$nulls":8},2,"NUCmer"]
["PAO1","PAO1R53","PA14R41",3171537,3173531,1995,2,2,{"$nulls":8},2,"NUCmer"]
["PAO1","PAO1R54","PA14R40",3434113,3436521,2409,3,3,{"$nulls":7},1,2,"NUCmer"]
["PAO1","PAO1R55","PA14R39",3450776,3450834,59,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R56","PA14R38",3526680,3547686,21007,19,19,0,{"$nulls":4},5,2,9,3,"NUCmer and Manual Edits"]
["PAO1","PAO1R57","PA14R37",3611091,3611193,103,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R58","PA14R36",3627725,3627733,9,1,{"$nulls":5},1,{"$nulls":3},1,"Manual Edits"]
["PAO1","PAO1R59","PA14R35",3773376,3773980,605,1,1,{"$nulls":8},1,"NUCmer"]
["PAO1","PAO1R60","PA14R34",3778604,3778604,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R61","PA14R33",3841861,3843522,1662,1,1,{"$nulls":7},1,null,"NUCmer"]
["PAO1","PAO1R62","PA14R32",3873956,3874168,213,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R63","PA14R31",3874340,3874560,221,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R64","PA14R30",3914108,3930739,16632,18,18,{"$nulls":7},9,9,"NUCmer"]
["PAO1","PAO1R65","PA14R29",4225569,4225657,89,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R66","PA14R28",4281832,4282137,306,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R67","PA14R27",4294584,4296771,2188,1,null,1,{"$nulls":7},1,"NUCmer and Manual Edits"]
["PAO1","PAO1R68","PA14R26",4303104,4305645,2542,3,1,1,1,{"$nulls":3},1,null,1,1,"NUCmer and Manual Edits"]
["PAO1","PAO1R69","PA14R25",4387196,4387336,141,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R70","PA14R24",4417080,4417814,735,1,1,{"$nulls":8},1,"NUCmer"]
["PAO1","PAO1R71","PA14R23",4473543,4474913,1371,1,1,{"$nulls":7},1,null,"NUCmer"]
["PAO1","PAO1R72","PA14R22",4528544,4528679,136,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R73","PA14R21",4575822,4575902,81,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R74","PA14R20",4584489,4591056,6568,7,7,{"$nulls":7},2,5,"NUCmer"]
["PAO1","PAO1R75","PA14R19",4658246,4658360,115,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R76","PA14R18",4688833,4693109,4277,5,5,{"$nulls":7},5,null,"NUCmer"]
["PAO1","PAO1R77","PA14R77",5069012,5072270,3259,3,1,1,1,{"$nulls":3},3,{"$nulls":3},"NUCmer and Manual Edits"]
["PAO1","PAO1R78","PA14R78",5086696,5086696,1,0,{"$nulls":10},"Manual Edits"]
["PAO1","PAO1R79","PA14R79",5097453,5104986,7534,8,5,3,{"$nulls":4},8,{"$nulls":3},"NUCmer"]
["PAO1","PAO1R80","PA14R80",5382520,5383890,1371,1,1,{"$nulls":7},1,null,"NUCmer"]
["PAO1","PAO1R81","PA14R81",5386918,5387754,837,1,1,{"$nulls":8},1,"NUCmer"]
["PAO1","PAO1R82","PA14R82",5469069,5469096,28,0,{"$nulls":10},"NUCmer"]
["PAO1","PAO1R83","PA14R83",5727163,5727338,176,1,{"$nulls":3},1,{"$nulls":5},1,"NUCmer and Manual Edits"]
["PAO1","PAO1R84","PA14R84",5925990,5930758,4769,2,2,null,0,{"$nulls":6},2,"NUCmer"]
["PAO1","PAO1R85","PA14R85",5988154,5988473,320,1,1,{"$nulls":8},1,"NUCmer"]

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["Additional data file 4: Summary of PA14- and PAO1-Specific Regions."]
["Strain-specific regions were initially defined using NUCmer-based global alignments.  In some cases, the NUCmer-based coordinates (columns D and E) were edited following manual inspection to fuse adjacent strain-specific regions into a single, contiguous region.  "]
["For each PA14-Specific Region, we indicate the corresponding region in PAO1, and vice versa (column C).  In some cases, a PA14-specifc region may be inserted in a corresponding region of PAO1 that cannot itself be designated a PAO1-specifid region as defined by NUCmer.  "]
["In these cases, we have created a virtual strain-specific region of only a single-nucleotide long that represents the approximate site of insertion of the PA14 region.  Similar single-nucleotide PA14-specific regions have been defined as approximate pointers to corresponding regions in which PAO1-specific regions are inserted.  "]
["Regions in each strain are named with the Strain name, followed “R” (for region), and a 2-digit number reflecting the relative order of each region in the respective genome (starting at the origin of replication and moving clockwise on the plus strand; Column A).  "]
["The total number of genes found in the region is shown in Column G.  Some regions contain no genes, either because NUCmer has defined a strain-specific region that has no predicted ORFs or because the regions are single nucleotide pointers to indicate the location of a corresponding region in the other strain.  "]
["The method by which the region coordinates were defined is listed in Column R, indicated that the start and stop of the region were defined by NUCmer analysis (NUCmer), the NUCmer-derived coordinates were modified by manual inspection of the genes included or overlapping the region (NUCmer + manual edits), or defined manually (manual edits only) based on the presence of genes with less-than 50% amino acid identity despite similar nucleotide sequence, or regions defined as single-nucleotide pointers for positions of corresponding regions in the other genome."]